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Sample records for bd imagn rwbc

  1. Bd/s -> mu+ mu- in ATLAS

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00215268; The ATLAS collaboration

    2016-01-01

    The ATLAS Experiment has conducted a search for the rare decays of Bs and Bd into mu+mu-. 25 fb−1 of integrated luminosity of proton-proton collisions collected during LHC Run 1 were studied and new results were obtained, as presented in this talk. An upper limit is set on the Bd to mu+mu- branching ratio of BR(Bd to mu+mu-) < 4.2×10−10 at 95% confidence level. For Bs, ATLAS measurement yields the branching ratio BR(Bs to mu+mu-)=(0.9+1.1−0.8)×10−9. The result is consistent with the Standard Model expectation and other available measurements.

  2. Bd/s -> mu+ mu- in ATLAS

    CERN Document Server

    Guenther, Jaroslav; The ATLAS collaboration

    2016-01-01

    The ATLAS Experiment has conducted a search for the rare decays of Bs and Bd into mu+mu-. 25 fb−1 of integrated luminosity of proton-proton collisions collected during LHC Run 1 were studied to provide new results presented in this talk. An upper limit is set on the branching ratio BR(Bd to mu+mu-) < 4.2×10−10 at 95% confidence level. For Bs, ATLAS measurement yields the branching ratio BR(Bs to mu+mu-)=(0.9+1.1−0.8)×10−9. The result is consistent with the Standard Model expectation and other available measurements.

  3. Far ultraviolet spectrophotometry of BD +28 4211

    Science.gov (United States)

    Cook, Timothy A.; Cash, Webster; Green, James C.

    1991-01-01

    The results are reported of a November 1989 rocket flight which recorded a flux-calibrated spectrum of BD +28 4211 from 912 to 1150 A with 1A resolution. BD +28 4211, an SdO-type star, is commonly used as an ultraviolet calibration source in the IUE wavelength band. The present work extends the useful range of this standard shortward of Lyman-alpha. Since previous experiments show marked disparity, this study can be useful in determining a standard in the 912 to 1216 A band.

  4. 黏合剂Argaprint BD-L%Adhesive Argaprint BD-L for pigment printing

    Institute of Scientific and Technical Information of China (English)

    李正雄

    2011-01-01

    Application of Argaprint BD-L in pigment printing of cotton fabric is carried out. The results show that cotton fabric printed with Argaprint BD-L from 15% to 30% and pigment from 3% to 8% feature good color fastness and soft handle, as well as lower formaldehyde residual content less than 20 mg/kg. The application performances of Argaprint BD-L are slightly affected by fabric structure and pigment type. It can meet the requirements of high fastness printing in deep color to use Argaprint BD-L combined with cross-linking agent Argaprint CL-SLF and promoter for rubbing fastness Argaprint PF-SO.%黏合剂Argaprint BD-L系自交联型黏合剂.当涂料用量为3%~8%,即从浅色到特深色印花,黏合剂Argaprint BD-L对应的用量为15%~30%(对色浆质量),均可获得良好的牢度和柔软的手感,且布面甲醛含量小于20 mg/kg.黏合剂Argaprint BD-L与配套的交联剂Argaprint CL-SLF和摩擦牢度提升剂Argaprint PF-SO联用,可满足高牢度要求的特深色印花.

  5. BdCESA7, BdCESA8, and BdPMT utility promoter constructs for targeted expression to secondary cell-wall-forming cells of grasses

    Directory of Open Access Journals (Sweden)

    Deborah ePetrik

    2016-02-01

    Full Text Available Utility vectors with promoters that confer desired spatial and temporal expression patterns are useful tools for studying gene and cellular function and for industrial applications. To target the expression of DNA sequences of interest to cells forming plant secondary cell walls, which generate most of the vegetative biomass, upstream regulatory sequences of the Brachypodium distachyon lignin biosynthetic gene BdPMT and the cellulose synthase genes BdCESA7 and BdCESA8 were isolated and cloned into binary vectors designed for Agrobacterium-mediated transformation of monocots. Expression patterns were assessed using the β-glucuronidase gene GUSPlus and X-glucuronide staining. All three promoters showed strong expression levels in stem tissue at the base of internodes where cell wall deposition is most active, in both vascular bundle xylem vessels and tracheids, and in interfascicular tissues, with expression less pronounced in developmentally older tissues. In leaves, BdCESA7 and BdCESA8 promoter-driven expression was strongest in leaf veins, leaf margins, and trichomes; relatively weaker and patchy expression was observed in the epidermis. BdPMT promoter-driven expression was similar to the BdCESA promoters expression patterns, including strong expression in trichomes. The intensity and extent of GUS staining varied considerably between transgenic lines, suggesting that positional effects influenced promoter activity. Introducing the BdPMT and BdCESA8 Open Reading Frames (ORFs into BdPMT and BdCESA8 utility promoter binary vectors, respectively, and transforming those constructs into Brachypodium pmt and cesa8 loss-of-function mutants resulted in rescue of the corresponding mutant phenotypes. This work therefore validates the functionality of these utility promoter binary vectors for use in Brachypodium and likely other grass species. The identification, in Bdcesa8-1 T-DNA mutant stems, of an 80% reduction in crystalline cellulose levels

  6. Widespread occurrence of bd in French Guiana, South America.

    Science.gov (United States)

    Courtois, Elodie A; Gaucher, Philippe; Chave, Jérôme; Schmeller, Dirk S

    2015-01-01

    The amphibian chytrid fungus Batrachochytrium dendrobatidis (Bd) is a purported agent of decline and extinction of many amphibian populations worldwide. Its occurrence remains poorly documented in many tropical regions, including the Guiana Shield, despite the area's high amphibian diversity. We conducted a comprehensive assessment of Bd in French Guiana in order to (1) determine its geographical distribution, (2) test variation of Bd prevalence among species in French Guiana and compare it to earlier reported values in other South American anuran species (http://www.bd-maps.net; 123 species from 15 genera) to define sentinel species for future work, (3) track changes in prevalence through time and (4) determine if Bd presence had a negative effect on one selected species. We tested the presence of Bd in 14 species at 11 sites for a total of 1053 samples (306 in 2009 and 747 in 2012). At least one Bd-positive individual was found at eight out of 11 sites, suggesting a wide distribution of Bd in French Guiana. The pathogen was not uniformly distributed among the studied amphibian hosts, with Dendrobatidae species displaying the highest prevalence (12.4%) as compared to Bufonidae (2.6 %) and Hylidae (1.5%). In contrast to earlier reported values, we found highest prevalence for three Dendrobatidae species and two of them displayed an increase in Bd prevalence from 2009 to 2012. Those three species might be the sentinel species of choice for French Guiana. For Dendrobates tinctorius, of key conservation value in the Guiana Shield, smaller female individuals were more likely to be infected, suggesting either that frogs can outgrow their chytrid infections or that the disease induces developmental stress limiting growth. Generally, our study supports the idea that Bd is more widespread than previously thought and occurs at remote places in the lowland forest of the Guiana shield.

  7. Widespread occurrence of bd in French Guiana, South America.

    Directory of Open Access Journals (Sweden)

    Elodie A Courtois

    Full Text Available The amphibian chytrid fungus Batrachochytrium dendrobatidis (Bd is a purported agent of decline and extinction of many amphibian populations worldwide. Its occurrence remains poorly documented in many tropical regions, including the Guiana Shield, despite the area's high amphibian diversity. We conducted a comprehensive assessment of Bd in French Guiana in order to (1 determine its geographical distribution, (2 test variation of Bd prevalence among species in French Guiana and compare it to earlier reported values in other South American anuran species (http://www.bd-maps.net; 123 species from 15 genera to define sentinel species for future work, (3 track changes in prevalence through time and (4 determine if Bd presence had a negative effect on one selected species. We tested the presence of Bd in 14 species at 11 sites for a total of 1053 samples (306 in 2009 and 747 in 2012. At least one Bd-positive individual was found at eight out of 11 sites, suggesting a wide distribution of Bd in French Guiana. The pathogen was not uniformly distributed among the studied amphibian hosts, with Dendrobatidae species displaying the highest prevalence (12.4% as compared to Bufonidae (2.6 % and Hylidae (1.5%. In contrast to earlier reported values, we found highest prevalence for three Dendrobatidae species and two of them displayed an increase in Bd prevalence from 2009 to 2012. Those three species might be the sentinel species of choice for French Guiana. For Dendrobates tinctorius, of key conservation value in the Guiana Shield, smaller female individuals were more likely to be infected, suggesting either that frogs can outgrow their chytrid infections or that the disease induces developmental stress limiting growth. Generally, our study supports the idea that Bd is more widespread than previously thought and occurs at remote places in the lowland forest of the Guiana shield.

  8. Measurement of the B$_{d}^{0}$ meson oscillation frequency

    CERN Document Server

    Acciarri, M; Aguilar-Benítez, M; Ahlen, S P; Alpat, B; Alcaraz, J; Alemanni, G; Allaby, James V; Aloisio, A; Alverson, G; Alviggi, M G; Ambrosi, G; Anderhub, H; Andreev, V P; Angelescu, T; Antreasyan, D; Arefev, A; Azemoon, T; Aziz, T; Bagnaia, P; Baksay, L; Ball, R C; Banerjee, S; Banicz, K; Barillère, R; Barone, L; Bartalini, P; Baschirotto, A; Basile, M; Battiston, R; Bay, A; Becattini, F; Becker, U; Behner, F; Berdugo, J; Berges, P; Bertucci, B; Betev, B L; Biasini, M; Biland, A; Bilei, G M; Blaising, J J; Blyth, S C; Bobbink, Gerjan J; Böck, R K; Böhm, A; Borgia, B; Boucham, A; Bourilkov, D; Bourquin, Maurice; Boutigny, D; Brambilla, Elena; Branson, J G; Brigljevic, V; Brock, I C; Buijs, A; Burger, J D; Burger, W J; Busenitz, J K; Buytenhuijs, A O; Cai, X D; Campanelli, M; Capell, M; Cara Romeo, G; Caria, M; Carlino, G; Cartacci, A M; Casaus, J; Castellini, G; Castello, R; Cavallari, F; Cavallo, N; Cecchi, C; Cerrada-Canales, M; Cesaroni, F; Chamizo-Llatas, M; Chan, A; Chang, Y H; Chaturvedi, U K; Chemarin, M; Chen, A; Chen, G; Chen, G M; Chen, H F; Chen, H S; Chen, M; Chiefari, G; Chien, C Y; Choi, M T; Cifarelli, Luisa; Cindolo, F; Civinini, C; Clare, I; Clare, R; Cohn, H O; Coignet, G; Colijn, A P; Colino, N; Costantini, S; Cotorobai, F; de la Cruz, B; Csilling, Akos; Dai, T S; D'Alessandro, R; De Asmundis, R; De Boeck, H; Degré, A; Deiters, K; Denes, P; De Notaristefani, F; DiBitonto, Daryl; Diemoz, M; Van Dierendonck, D N; Di Lodovico, F; Dionisi, C; Dittmar, Michael; Dominguez, A; Doria, A; Dorne, I; Dova, M T; Drago, E; Duchesneau, D; Duinker, P; Durán, I; Dutta, S; Easo, S; Efremenko, Yu V; El-Mamouni, H; Engler, A; Eppling, F J; Erné, F C; Ernenwein, J P; Extermann, Pierre; Fabre, M; Faccini, R; Falciano, S; Favara, A; Fay, J; Fedin, O; Felcini, Marta; Ferguson, T; Fernández, D; Ferroni, F; Fesefeldt, H S; Fiandrini, E; Field, J H; Filthaut, Frank; Fisher, P H; Forconi, G; Fredj, L; Freudenreich, Klaus; Furetta, C; Galaktionov, Yu; Ganguli, S N; Gau, S S; Gentile, S; Gerald, J; Gheordanescu, N; Giagu, S; Goldfarb, S; Goldstein, J; Gong, Z F; Gougas, Andreas; Gratta, Giorgio; Grünewald, M W; Gupta, V K; Gurtu, A; Gutay, L J; Hangarter, K; Hartmann, B; Hasan, A; Hebbeker, T; Hervé, A; Van Hoek, W C; Hofer, H; Hoorani, H; Hou, S R; Hu, G; Ilyas, M M; Innocente, Vincenzo; Janssen, H; Jin, B N; Jones, L W; de Jong, P; Josa-Mutuberria, I; Kasser, A; Khan, R A; Kamyshkov, Yu A; Kapinos, P; Kapustinsky, J S; Karyotakis, Yu; Kaur, M; Kienzle-Focacci, M N; Kim, D; Kim, J K; Kim, S C; Kim, Y G; Kinnison, W W; Kirkby, A; Kirkby, D; Kirkby, Jasper; Kiss, D; Kittel, E W; Klimentov, A; König, A C; Korolko, I; Koutsenko, V F; Krämer, R W; Kramer, T; Krenz, W; Kuijten, H; Kunin, A; Ladrón de Guevara, P; Landi, G; Lapoint, C; Lassila-Perini, K M; Laurikainen, P; Lebeau, M; Lebedev, A; Lebrun, P; Lecomte, P; Lecoq, P; Le Coultre, P; Lee Jae Sik; Lee, K Y; Leggett, C; Le Goff, J M; Leiste, R; Lenti, M; Leonardi, E; Levchenko, P M; Li Chuan; Lieb, E H; Lin, W T; Linde, Frank L; Lista, L; Liu, Z A; Lohmann, W; Longo, E; Lu, W; Lü, Y S; Lübelsmeyer, K; Luci, C; Luckey, D; Ludovici, L; Luminari, L; Lustermann, W; Ma Wen Gan; Macchiolo, A; Maity, M; Majumder, G; Malgeri, L; Malinin, A; Maña, C; Mangla, S; Marchesini, P A; Marin, A; Martin, J P; Marzano, F; Massaro, G G G; Mazumdar, K; McNally, D; Mele, S; Merola, L; Meschini, M; Metzger, W J; Von der Mey, M; Mi, Y; Mihul, A; Van Mil, A J W; Mirabelli, G; Mnich, J; Monteleoni, B; Moore, R; Morganti, S; Mount, R; Müller, S; Muheim, F; Nagy, E; Nahn, S; Napolitano, M; Nessi-Tedaldi, F; Newman, H; Nippe, A; Nowak, H; Organtini, G; Ostonen, R; Pandoulas, D; Paoletti, S; Paolucci, P; Park, H K; Pascale, G; Passaleva, G; Patricelli, S; Paul, T; Pauluzzi, M; Paus, C; Pauss, Felicitas; Peach, D; Pei, Y J; Pensotti, S; Perret-Gallix, D; Petrak, S; Pevsner, A; Piccolo, D; Pieri, M; Pinto, J C; Piroué, P A; Pistolesi, E; Plyaskin, V; Pohl, M; Pozhidaev, V; Postema, H; Produit, N; Prokofev, D; Prokofiev, D O; Raghavan, R; Rahal-Callot, G; Rancoita, P G; Rattaggi, M; Raven, G; Razis, P A; Read, K; Ren, D; Rescigno, M; Reucroft, S; Van Rhee, T; Riemann, S; Riemers, B C; Riles, K; Rind, O; Ro, S; Robohm, A; Rodin, J; Rodríguez-Calonge, F J; Roe, B P; Röhner, S; Romero, L; Rosier-Lees, S; Rosselet, P; Van Rossum, W; Roth, S; Rubio, Juan Antonio; Rykaczewski, H; Salicio, J; Sánchez, E; Santocchia, A; Sarakinos, M E; Sarkar, S; Sassowsky, M; Sauvage, G; Schäfer, C; Shchegelskii, V; Schmidt-Kärst, S; Schmitz, D; Schmitz, P; Schneegans, M; Schöneich, B; Scholz, N; Schopper, Herwig Franz; Schotanus, D J; Schwenke, J; Schwering, G; Sciacca, C; Sciarrino, D; Sens, Johannes C; Servoli, L; Shevchenko, S; Shivarov, N; Shoutko, V; Shukla, J; Shumilov, E; Shvorob, A V; Siedenburg, T; Son, D; Sopczak, André; Soulimov, V; Smith, B; Spillantini, P; Steuer, M; Stickland, D P; Sticozzi, F; Stone, H; Stoyanov, B; Strässner, A; Strauch, K; Sudhakar, K; Sultanov, G G; Sun, L Z; Susinno, G F; Suter, H; Swain, J D; Tang, X W; Tauscher, Ludwig; Taylor, L; Ting, Samuel C C; Ting, S M; Tonisch, F; Tonutti, M; Tonwar, S C; Tóth, J; Tully, C; Tuchscherer, H; Tung, K L; Ulbricht, J; Uwer, U; Valente, E; Van de Walle, R T; Vesztergombi, G; Vetlitskii, I; Viertel, Gert M; Vivargent, M; Völkert, R; Vogel, H; Vogt, H; Vorobev, I; Vorobyov, A A; Vorvolakos, A; Wadhwa, M; Wallraff, W; Wang, J C; Wang, X L; Wang, Y F; Wang, Z M; Weber, A; Wittgenstein, F; Wu, S X; Wynhoff, S; Xu, J; Xu, Z Z; Yang, B Z; Yang, C G; Yao, X Y; Ye, J B; Yeh, S C; You, J M; Zalite, A; Zalite, Yu; Zemp, P; Zeng, Y; Zhang, Z; Zhang, Z P; Zhou, B; Zhou, Y; Zhu, G Y; Zhu, R Y; Zichichi, Antonino

    1996-01-01

    Time-dependent \\Bd-\\Bbd\\ mixing is studied using 1.5 million hadronic Z decays collected by L3. Semileptonic B decays are selected by requiring at least one reconstructed lepton in both thrust hemispheres. Charge correlations between the tagged leptons are studied as a function of proper time. The proper time of the b-hadron decay is measured by reconstructing the production and decay vertices using a silicon microvertex detector. The measured \\Bd\\ meson oscillation frequency corresponds to a mass difference \\Dmd\\ between the two \\Bd\\ mass eigenstates of \\begin{displaymath} \\Dmd = \\left( 0.496 ^{+ 0.055}_{- 0.051}\\ \\mathrm{(stat)} \\pm{ 0.043}\\ \\mathrm{(syst)} \\right)\\ \\mathrm{ps}^{-1}. \\end{displaymath}

  9. Construction of Eukaryotic Expression Vector with mBD1-mBD3 Fusion Genes and Exploring Its Activity against Influenza A Virus

    Directory of Open Access Journals (Sweden)

    Wanyi Li

    2014-03-01

    Full Text Available Influenza (flu pandemics have exhibited a great threat to human health throughout history. With the emergence of drug-resistant strains of influenza A virus (IAV, it is necessary to look for new agents for treatment and transmission prevention of the flu. Defensins are small (2–6 kDa cationic peptides known for their broad-spectrum antimicrobial activity. Beta-defensins (β-defensins are mainly produced by barrier epithelial cells and play an important role in attacking microbe invasion by epithelium. In this study, we focused on the anti-influenza A virus activity of mouse β-defensin 1 (mBD1 and β defensin-3 (mBD3 by synthesizing their fusion peptide with standard recombinant methods. The eukaryotic expression vectors pcDNA3.1(+/mBD1-mBD3 were constructed successfully by overlap-PCR and transfected into Madin-Darby canine kidney (MDCK cells. The MDCK cells transfected by pcDNA3.1(+/mBD1-mBD3 were obtained by G418 screening, and the mBD1-mBD3 stable expression pattern was confirmed in MDCK cells by RT-PCR and immunofluorescence assay. The acquired stable transfected MDCK cells were infected with IAV (A/PR/8/34, H1N1, 0.1 MOI subsequently and the virus titers in cell culture supernatants were analyzed by TCID50 72 h later. The TCID50 titer of the experimental group was clearly lower than that of the control group (p < 0.001. Furthermore, BALB/C mice were injected with liposome-encapsulated pcDNA3.1(+/mBD1-mBD3 through muscle and then challenged with the A/PR/8/34 virus. Results showed the survival rate of 100% and lung index inhibitory rate of 32.6% in pcDNA3.1(+/mBD1-mBD3group; the TCID50 titer of lung homogenates was clearly lower than that of the control group (p < 0.001. This study demonstrates that mBD1-mBD3 expressed by the recombinant plasmid pcDNA3.1(+/mBD1-mBD3 could inhibit influenza A virus replication both in vitro and in vivo. These observations suggested that the recombinant mBD1-mBD3 might be developed into an agent for

  10. Photometry and Spectroscopy of BD+35 1111 in M38

    Science.gov (United States)

    Souza, Steven P.; Kwitter, Karen B.; Sami, Mona; Beltz-Mohrmann, Gillian

    2014-06-01

    BD+35 1111 is a ~10.5-magnitude star in the field of M38, an open cluster that has been a target of our ongoing study of Hα emission variability in massive stars via narrowband CCD photometry (e.g. Souza, Davis, and Teich 2013, BAAS. 45, PM354.22). BD+35 1111 has no MKK classification in the literature, and is not listed as variable in GCVS, VSX, or NSVS. It is included, with no further characterization, in both the Vatican and Kohoutek catalogs of emission line stars. Using inhomogeneous ensemble photometry (e.g. Bhatti, Richmond, Ford, and Petro 2010, ApJ Supp., 186, 233), we find it to be an irregular variable with a range of ~0.15 mag. To further understand this star we obtained a medium-resolution spectrum using the DIS spectrograph on the ARC 3.5-meter telescope at Apache Point Observatory. We classify BD+35 1111 as B2Ve, the only confirmed Be star in the field of M38. This raises the question of membership, since the age of M38 is likely 250 Ma or greater (Pandey et al. 2007, Publ. Astron. Soc. Japan 59, 547). From published B and V magnitudes we find a nominal distance to BD+35 1111 of 1.6 kpc, but with a range of 1.3 to 2.0 kpc, marginally consistent with distance estimates for M38 ranging from 1.0 to 1.4 kpc. If a member, BD+35 1111 is a candidate blue straggler. If not, it may have escaped from a nearby younger cluster, possibly Kronberger 1 (Kronberger et al. 2006, A&A 447, 921), which has the right heliocentric distance and age. The notion that BD+35 1111 is behind M38 is supported by its reddening of EB-V ~ 0.5, significantly higher than for M38 itself 0.24). We gratefully acknowledge support for student research from NSF grant AST-1005024 to the Keck Northeast Astronomy Consortium, Williams College, and NASA via an American Astronomical Society Small Research Grant.

  11. Trajectory and physical properties of near-Earth asteroid 2009 BD

    NARCIS (Netherlands)

    Chesley, Steven R.; Mommert, Michael; Hora, Joseph L.; Farnocchia, Davide; Trilling, David E.; Vokrouhlický, David; Mueller, Michael; Harris, Alan W; Smith, Howard Alan; Fazio, Giovanni G.

    2014-01-01

    We analyze the trajectory of near-Earth asteroid 2009 BD, which is a candidate target of the NASA Asteroid Robotic Retrieval Mission (ARRM). The small size of 2009 BD and its Earth-like orbit pose challenges to understanding the dynamical properties of 2009 BD. In particular, nongravitational pertur

  12. Trajectory and physical properties of near-Earth asteroid 2009 BD

    NARCIS (Netherlands)

    Farnocchia, D.; Mommert, M.; Hora, J. L.; Chesley, S. R.; Vokrouhlický, D.; Trilling, D. E.; Mueller, M.; Harris, A. W.; Smith, H. A.; Fazio, G. G.; Knežević, Zoran; Lemaitre, Anne

    2014-01-01

    We analyze the trajectory of near-Earth asteroid 2009~BD, which is a candidate target of the NASA Asteroid Redirect Mission. The small size of 2009 BD and its Earth-like orbit pose challenges to understanding the dynamical properties of 2009 BD. In particular, nongravitational perturbations, such as

  13. A Gamma Doradus Candidate In Eclipsing Binary BD And?

    CERN Document Server

    Sipahi, E

    2013-01-01

    The BVR photometric light curves of the eclipsing binary BD And were obtained in 2008 and 2009. We estimated the mass ratio of the system as 0.97 and the photometric solutions were derived. The results show that BD And is a detached binary system, whose components have a little temperature difference of about 40 K. By analyzing photometric available light minimum times, we also derived an update ephemeris and found for the first time a possible periodic oscillation with an amplitude of 0.011 days and a period of 9.6 years. The results indicate that the periodic oscillation could be caused by a third component physically attached to the eclipsing binary. After removing the light variations due to the eclipses and proximity effects, the light-curve distortions are further explained by the pulsation of the primary component with a dominant period of 1 day. In accordance with the position of the primary component on the Hertzsprung-Russell diagram and its pulsation period, the primary component of BD And could be...

  14. 78 FR 75511 - Special Conditions: Bombardier Inc., Models BD-500-1A10 and BD-500-1A11 Series Airplanes...

    Science.gov (United States)

    2013-12-12

    ... design feature associated with control surface awareness and mode annunciation of the electronic flight... airplanes will incorporate the following novel or unusual design features: A fly-by-wire electronic flight... Inc., Models BD-500-1A10 and BD- 500-1A11 Series Airplanes; Electronic Flight Control System:...

  15. High Production of 2,3-Butanediol (2,3-BD) by Raoultella ornithinolytica B6 via Optimizing Fermentation Conditions and Overexpressing 2,3-BD Synthesis Genes

    Science.gov (United States)

    Kim, Taeyeon; Cho, Sukhyeong; Lee, Sun-Mi; Woo, Han Min; Lee, Jinwon; Seo, Jin-Ho

    2016-01-01

    Biological production of 2,3-butandiol (2,3-BD) has received great attention as an alternative to the petroleum-based 2,3-BD production. In this study, a high production of 2,3-BD in fed-batch fermentation was investigated with a newly isolated bacterium designated as Raoultella ornithinolytica B6. The isolate produced 2,3-BD as the main product using hexoses (glucose, galactose, and fructose), pentose (xylose) and disaccharide (sucrose). The effects of temperature, pH-control schemes, and agitation speeds on 2,3-BD production were explored to optimize the fermentation conditions. Notably, cell growth and 2,3-BD production by R. ornithinolytica B6 were higher at 25°C than at 30°C. When three pH control schemes (no pH control, pH control at 7, and pH control at 5.5 after the pH was decreased to 5.5 during fermentation) were tested, the best 2,3-BD titer and productivity along with reduced by-product formation were achieved with pH control at 5.5. Among different agitation speeds (300, 400, and 500 rpm), the optimum agitation speed was 400 rpm with 2,3-BD titer of 68.27 g/L, but acetic acid was accumulated up to 23.32 g/L. Further enhancement of the 2,3-BD titer (112.19 g/L), yield (0.38 g/g), and productivity (1.35 g/L/h) as well as a significant reduction of acetic acid accumulation (9.71 g/L) was achieved by the overexpression of homologous budABC genes, the 2,3-BD-synthesis genes involved in the conversion of pyruvate to 2,3-BD. This is the first report presenting a high 2,3-BD production by R.ornithinolytica which has attracted little attention with respect to 2,3-BD production, extending the microbial spectrum of 2,3-BD producers. PMID:27760200

  16. Activity of Bdellovibrio hit locus proteins, Bd0108 and Bd0109, links Type IVa pilus extrusion/retraction status to prey-independent growth signalling.

    Directory of Open Access Journals (Sweden)

    Michael J Capeness

    Full Text Available Bdellovibrio bacteriovorus are facultatively predatory bacteria that grow within gram-negative prey, using pili to invade their periplasmic niche. They also grow prey-independently on organic nutrients after undergoing a reversible switch. The nature of the growth switching mechanism has been elusive, but several independent reports suggested mutations in the hit (host-interaction locus on the Bdellovibrio genome were associated with the transition to prey-independent growth. Pili are essential for prey entry by Bdellovibrio and sequence analysis of the hit locus predicted that it was part of a cluster of Type IVb pilus-associated genes, containing bd0108 and bd0109. In this study we have deleted the whole bd0108 gene, which is unique to Bdellovibrio, and compared its phenotype to strains containing spontaneous mutations in bd0108 and the common natural 42 bp deletion variant of bd0108. We find that deletion of the whole bd0108 gene greatly reduced the extrusion of pili, whereas the 42 bp deletion caused greater pilus extrusion than wild-type. The pili isolated from these strains were comprised of the Type IVa pilin protein; PilA. Attempts to similarly delete gene bd0109, which like bd0108 encodes a periplasmic/secreted protein, were not successful, suggesting that it is likely to be essential for Bdellovibrio viability in any growth mode. Bd0109 has a sugar binding YD- repeat motif and an N-terminus with a putative pilin-like fold and was found to interact directly with Bd0108. These results lead us to propose that the Bd0109/Bd0108 interaction regulates pilus production in Bdellovibrio (possibly by interaction with the pilus fibre at the cell wall, and that the presence (and possibly retraction state of the pilus feeds back to alter the growth state of the Bdellovibrio cell. We further identify a novel small RNA encoded by the hit locus, the transcription of which is altered in different bd0108 mutation backgrounds.

  17. GHB, GBL and 1,4-BD addiction.

    Science.gov (United States)

    Brunt, Tibor M; van Amsterdam, Jan G C; van den Brink, Wim

    2014-01-01

    A growing body of evidence shows that gamma-hydroxybutyric acid (GHB) is an addictive substance. Its precursors gammabutyrolactone (GBL) and 1,4-butanediol (1,4-BD) show the same properties and may pose even more risks due to different pharmacokinetics. There are indications that problematic GHB use is increasing in the European Union. This review investigates the existing literature on the neurochemistry of GHB and its precursors, their acute toxicity, addiction potential and withdrawal, the proposed molecular mechanism underlying addiction and the treatment of withdrawal and addiction. Current evidence shows that GHB and its precursors are highly addictive, both in humans and animals, probably through a GABAB receptor related mechanism. Severity of withdrawal symptoms can be considered as a medical emergency. Recent studies suggest that benzodiazepines are not very effective, showing a high treatment resistance, whereas detoxification with pharmaceutical GHB proved to be successful. However, relapse in GHB use is frequent and more research is warranted on relapse prevention. This might aid medical practitioners in the field and improve general understanding of the severity of addiction to GHB, GBL and 1,4-BD.

  18. La base de datos BD.EURS (NACE Rev.1

    Directory of Open Access Journals (Sweden)

    Javier Escriba

    2014-01-01

    Full Text Available El objetivo de este documento es el de presentar la base de datos de regiones europeas desagregadas sectorialmente BD.EURS. Esta base es el resultado de analizar la calidad y la congruencia de las diferentes fuentes estadísticas disponibles sobre las variables macroeconómicas básicas —VAB en nominales y reales, empleo, formación bruta de capital fijo y stock de capital— para los países y a nivel NUTS-2. En esta primera versión de la BD.EURS nos hemos limitado a 121 regiones de nueve países europeos, aquellas regiones en las que se dispone de mayor calidad y cantidad de información para el periodo 1995-2007. Éstas son: las regiones de Bélgica, Alemania, Francia, Italia, Holanda, Austria, Portugal, Suecia y España. La fuente básica de información son las series regionales de EUROSTAT y utilizando también como referencia la información existente para países especialmente en las bases AMECO y EU-KLEMS.

  19. BD380: The Wild Card for Semi-automatic Rotor Spinning Mills%BD380——半自动转杯纺纱厂的王牌

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ 苏拉(捷克)公司以BD 380型半自动转杯纺纱机给了市场一个惊喜.BD 380型转杯纺纱机纺杯转速最高达11万r/min,引纱速度最快达180m/min,纺纱器最多达352个.BD 380标志着高质、高产和高产品适应性.

  20. BD380半自动转杯纺纱机%BD380 the wild card for semi-automatic rotor spinning mills

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    苏拉(捷克)公司以BD380型半自动转杯纺纱机给市场一个惊喜。BD380型转杯纺纱机纺杯转速最高达110000r/rain,引纱速度最快达180m/min,纺纱器最多达352个。BD380标志着高质量、高产量和高产品适应性(图1)。

  1. DevelopmentofagraphicaluserinterfaceforBD/GPSsimulatorbasedonmatlabprogram%基于MATLAB的BD/GPS模拟器界面显控软件设

    Institute of Scientific and Technical Information of China (English)

    李银虎; 王帅; 古泉颖

    2013-01-01

    MATLAB具有方便的硬件接口函数,可以作为PC上位机的显控软件平台。利用图形用户界面设计向导GUIDE设计了显示控制界面程序,通过串口与BD/GPS卫星信号模拟器主机进行通信,实现卫星信息的显示,并下发控制命令,介绍了详细的步骤和架构。%Matlab is powerful software for large engineering calculations and scientific simulation. It’s necessary and convenient to develop a Graphical User Interface (GUI) if one’s program has too many input parameters. In this paper a Graphical User Interface is designed for a BD/GPS satellite signal simulator through serial interface. It can be used for inputting parameters, and for satellite information display and control.

  2. Detection of radiation pressure acting on 2009 BD

    CERN Document Server

    Micheli, Marco; Elliott, Garrett T

    2011-01-01

    We report the direct detection of radiation pressure on the asteroid 2009 BD, one of the smallest multi-opposition near-Earth objects currently known, with H ~ 28.4. Under the purely gravitational model of NEODyS the object is currently considered a possible future impactor, with impact solutions starting in 2071. The detection of a radiation-related acceleration allows us to estimate an Area to Mass Ratio (AMR) for the object, that can be converted (under some assumptions) into a range of possible values for its average density. Our result AMR = (2.97 \\pm 0.33) x 10^(-4) m^2 kg^(-1) is compatible with the object being of natural origin, and it is narrow enough to exclude a man-made nature. The possible origin of this object, its future observability, and the importance of radiation pressure in the impact monitoring process, are also discussed.

  3. A Dynamical Investigation of the Proposed BD +20 2457 System

    CERN Document Server

    Horner, Jonathan; Hinse, Tobias C; Marshall, Jonathan P

    2014-01-01

    We present a detailed dynamical analysis of the orbital stability of the BD +20 2457 system, which features planets or brown dwarfs moving on relatively eccentric orbits. We find that the system exhibits strong dynamical instability on astronomically short timescales across a wide range of plausible orbital eccentricities, semi-major axes, and inclinations. If the system truly hosts massive planets or brown dwarfs, our results suggest that they must move on orbits significantly different to those proposed in the discovery work. If that is indeed the case, then it is likely that the best-fit orbital solutions for the proposed companions will change markedly as future observations are made. Such observations may result in the solution shifting to a more dynamically-stable regime, potentially one where stability is ensured by mutually resonant motion.

  4. The analysis of B-d ->(eta, eta ')l(+)l(-) decays in the standard model

    NARCIS (Netherlands)

    Erkol, G; Turan, G

    2003-01-01

    We study the differential branching ratio, the branching ratio and the CP-violating asymmetry for the exclusive B-d --> (eta,eta')l(+)l(-) decays in the standard model. We deduce the B-d --> (eta,eta') form factors from the form factors of B --> pi available in the literature, by using the SU(3)(F)

  5. ISO spectroscopy of young intermediate-mass stars in the BD+40 degrees 4124 group

    NARCIS (Netherlands)

    van den Ancker, ME; Wesselius, PR; Tielens, AGGM

    2000-01-01

    We present the results of ISO SWS and LWS grating scans towards the three brightest members of the BD+40 degrees 4124 group in the infrared: BD+40 degrees 4124 (B2Ve), LkH alpha 224 (A7e) and the embedded source LkH alpha 225. Emission from the pure rotational lines of H(2). from re-vibrational tran

  6. Increased expression and levels of human β defensins (hBD2 and hBD4 in adults with dental caries

    Directory of Open Access Journals (Sweden)

    Girolamo Jose Barrera

    2013-09-01

    Full Text Available Introduction: Defensins are small anti-microbial peptides produced by epithelial cells. These peptides have a broad range of actions against microorganisms, including Gram-positive and Gram-negative bacteria.Human defensins are classifi ed into two subfamilies, the α-, and β- defensins, which differ in their distribution of disulphide bonds between the six conserved cysteine residues. Defensins are found in salivaand others compartments of the body. Human β defensins 2 (hBD2, beta defensins 4 (hBD4 and alpha defensins 4 (hNP4 in saliva may contributes to vulnerability or resistance to caries. This study aimed to determine a possible correlation between caries and levels of defensins measuring the expression in gingival tissue and concentrations in saliva samples.Methods: Oral examinations were performed on 100 adults of both genders (18-30 years old, and unstimulated whole saliva was collected for immunoassays of the three peptides and for the salivary pH, buffercapacity, protein, and peroxidase activity. mRNA levels of defensins in gingival sample were assessed by semi-quantitative RT-PCR technique.Results: The median salivary levels of hBD2 and hBD4 were 1.88 μg/ml and 0.86 μg/ml respectively for the caries-free group (n=44 and 7.26 μ/ml (hBD2 and 4.25 μg/ml (hBD4 for all subjects with evidenceof caries (n=56. There was no difference in the levels of hNP4, salivary pH, and proteins between groups, however the peroxidase activity and buffer capacity (interval 6.0-5.0 were reduced in caries group. Transcriptional levels of hBD2 and hBD4 did correlate with caries experience, the mRNA expression of hBD2 and hBD4 were signifi cantly higher in patients with caries than in patients with no-caries (p Conclusion: We conclude that high salivary levels and expression of beta defensins, low peroxidase activity and buffer capacity may represent a biological response of oral tissue to caries. Our observation couldlead to new ways to prevent caries

  7. Increased expression and levels of human β defensins (hBD2 and hBD4 in adults with dental caries

    Directory of Open Access Journals (Sweden)

    Girolamo Jose Barrera

    2013-09-01

    Full Text Available Introduction: Defensins are small anti-microbial peptides produced by epithelial cells. These peptides have a broad range of actions against microorganisms, including Gram-positive and Gram-negative bacteria.Human defensins are classifi ed into two subfamilies, the α-, and β- defensins, which differ in their distribution of disulphide bonds between the six conserved cysteine residues. Defensins are found in salivaand others compartments of the body. Human β defensins 2 (hBD2, beta defensins 4 (hBD4 and alpha defensins 4 (hNP4 in saliva may contributes to vulnerability or resistance to caries. This study aimed to determine a possible correlation between caries and levels of defensins measuring the expression in gingival tissue and concentrations in saliva samples.Methods: Oral examinations were performed on 100 adults of both genders (18-30 years old, and unstimulated whole saliva was collected for immunoassays of the three peptides and for the salivary pH, buffercapacity, protein, and peroxidase activity. mRNA levels of defensins in gingival sample were assessed by semi-quantitative RT-PCR technique.Results: The median salivary levels of hBD2 and hBD4 were 1.88 μg/ml and 0.86 μg/ml respectively for the caries-free group (n=44 and 7.26 μ/ml (hBD2 and 4.25 μg/ml (hBD4 for all subjects with evidenceof caries (n=56. There was no difference in the levels of hNP4, salivary pH, and proteins between groups, however the peroxidase activity and buffer capacity (interval 6.0-5.0 were reduced in caries group. Transcriptional levels of hBD2 and hBD4 did correlate with caries experience, the mRNA expression of hBD2 and hBD4 were signifi cantly higher in patients with caries than in patients with no-caries (p < 0.01.Conclusion: We conclude that high salivary levels and expression of beta defensins, low peroxidase activity and buffer capacity may represent a biological response of oral tissue to caries. Our observation couldlead to new ways to prevent

  8. The Cytochrome bd Oxidase of Porphyromonas gingivalis Contributes to Oxidative Stress Resistance and Dioxygen Tolerance.

    Directory of Open Access Journals (Sweden)

    Julia Leclerc

    Full Text Available Porphyromonas gingivalis is an etiologic agent of periodontal disease in humans. The disease is associated with the formation of a mixed oral biofilm which is exposed to oxygen and environmental stress, such as oxidative stress. To investigate possible roles for cytochrome bd oxidase in the growth and persistence of this anaerobic bacterium inside the oral biofilm, mutant strains deficient in cytochrome bd oxidase activity were characterized. This study demonstrated that the cytochrome bd oxidase of Porphyromonas gingivalis, encoded by cydAB, was able to catalyse O2 consumption and was involved in peroxide and superoxide resistance, and dioxygen tolerance.

  9. Component validation of direct diode 488nm lasers in BD Accuri C6 flow cytometers

    Science.gov (United States)

    Chen, Wei P.; Luo, Ningyi D.

    2016-03-01

    The 488nm laser is the most important excitation light source of flow cytometry. The indirect diode (frequency-doubled diode) 488nm lasers are used in the excitation of Becton Dickinson (BD) AccuriTM C6. For using cost effective lasers, we have validated direct diode 488nm lasers as the replacement component of frequency-doubled diode laser. BD Bioscience issued the protocols to cover wavelength, power, noise, and polarization at the operation temperature range of cytometer. Pavilion Integration Corporation (PIC) tested 6 samples as the component validation of direct diode 488nm lasers based on the protocols from BD Biosciences. BD Bioscience also tested one of laser samples to further validate the test results of power, noise, and polarization from PIC.

  10. Effect of flavor-changing neutral currents in the leptonic asymmetry in Bd decays

    Science.gov (United States)

    Branco, G. C.; Parada, P. A.; Morozumi, T.; Rebelo, M. N.

    1993-06-01

    We evaluate the charge asymmetry in equal sign dileptons arising from the decay of a Bd0-Bd0 pair, in the presence of Z-mediated flavor-changing neutral currents. We compare our predictions with those of the standard model and the superweak model. Work supported by the Deprtment of Energy, contract DEAC03-76SF00515 and by a fellowship from OTAN (NATO).

  11. Characterization of Phosphate Transporters BdPT4 and BdPT8 in Mycorrhizal and Non-Mychorrhizal Brachypodium distachyon

    DEFF Research Database (Denmark)

    Clausen, Signe Sandbech

    was generated by Agrobacterium tumefaciens-mediated transformation. The transgenic lines were characterized for effects on growth and plant P uptake, and their subcellular localization was moreover determined by confocal microscopy. Quantitative expression analysis of 11 BdPTs in AM and non-mycorrhizal (NM...

  12. Guillem Fabre, “Pus dels majors” (BdT 216.2; Id., “Hon mais vey, pus truep sordeyor” (BdT 216.1

    Directory of Open Access Journals (Sweden)

    Linda Paterson

    2013-03-01

    Full Text Available The historical circumstances of Guillem Fabre’s two surviving sirventes has given rise to widely divergent views. This essay builds on Parducci’s contextualisation of BdT 216.2 during the War of the Sicilian Vespers and the so-called Aragonese crusade by the French against Pere III of Aragon in 1284-1285. It argues that Guillem is likely to be referring to events say entre nos because Narbonne was the focal point of the gathering French army and preaching of the crusade. All other textual details are compatible with this period and best explained by this context. But while Parducci places the sirventes in May 1285, it must in fact have preceded the death of Martin IV on 29 March, since his speedily-appointed successor Honorius IV could not be blamed for not having preached a crusade against the heathen before the conflict degenerated into further atrocities. Furthermore a slightly earlier timing better explains the allusion to “the best-known man in the world”, the obvious candidate at this time being Charles of Anjou. Guillem probably composed BdT 216.2 during the build-up to war in 1284, before the death of Charles in January 1285, during the period of war preparations and propaganda speeches. It is also argued here that, pace Parducci, BdT 216.1 did not necessarily precede BdT 216.2.

  13. Clinical management and burden of bipolar disorder: a multinational longitudinal study (WAVE-bd Study

    Directory of Open Access Journals (Sweden)

    Moreno-Manzanaro Miriam

    2011-04-01

    Full Text Available Abstract Background Studies in bipolar disorder (BD to date are limited in their ability to provide a whole-disease perspective - their scope has generally been confined to a single disease phase and/or a specific treatment. Moreover, most clinical trials have focused on the manic phase of disease, and not on depression, which is associated with the greatest disease burden. There are few longitudinal studies covering both types of patients with BD (I and II and the whole course of the disease, regardless of patients' symptomatology. Therefore, the Wide AmbispectiVE study of the clinical management and burden of Bipolar Disorder (WAVE-bd (NCT01062607 aims to provide reliable information on the management of patients with BD in daily clinical practice. It also seeks to determine factors influencing clinical outcomes and resource use in relation to the management of BD. Methods WAVE-bd is a multinational, multicentre, non-interventional, longitudinal study. Approximately 3000 patients diagnosed with BD type I or II with at least one mood event in the preceding 12 months were recruited at centres in Austria, Belgium, Brazil, France, Germany, Portugal, Romania, Turkey, Ukraine and Venezuela. Site selection methodology aimed to provide a balanced cross-section of patients cared for by different types of providers of medical aid (e.g. academic hospitals, private practices in each country. Target recruitment percentages were derived either from scientific publications or from expert panels in each participating country. The minimum follow-up period will be 12 months, with a maximum of 27 months, taking into account the retrospective and the prospective parts of the study. Data on demographics, diagnosis, medical history, clinical management, clinical and functional outcomes (CGI-BP and FAST scales, adherence to treatment (DAI-10 scale and Medication Possession Ratio, quality of life (EQ-5D scale, healthcare resources, and caregiver burden (BAS scale

  14. High Milk-Clotting Activity Expressed by the Newly Isolated Paenibacillus spp. Strain BD3526

    Directory of Open Access Journals (Sweden)

    Feng Hang

    2016-01-01

    Full Text Available Paenibacillus spp. BD3526, a bacterium exhibiting a protein hydrolysis circle surrounded with an obvious precipitation zone on skim milk agar, was isolated from raw yak (Bos grunniens milk collected in Tibet, China. Phylogenetic analysis based on 16S rRNA and whole genome sequence comparison indicated the isolate belong to the genus Paenibacillus. The strain BD3526 demonstrated strong ability to produce protease with milk clotting activity (MCA in wheat bran broth. The protease with MCA was predominantly accumulated during the late-exponential phase of growth. The proteolytic activity (PA of the BD3526 protease was 1.33-fold higher than that of the commercial R. miehei coagulant. A maximum MCA (6470 ± 281 SU mL−1 of the strain BD3526 was reached under optimal cultivation conditions. The protease with MCA was precipitated from the cultivated supernatant of wheat bran broth with ammonium sulfate and purified by anion-exchange chromatography. The molecular weight of the protease with MCA was determined as 35 kDa by sodium dodecyl sulfate-polyacrylamide gels electrophoresis (SDS-PAGE and gelatin zymography. The cleavage site of the BD3526 protease with MCA in κ-casein was located at the Met106–Ala107 bond, as determined by mass spectrometry analysis.

  15. BD-Func: a streamlined algorithm for predicting activation and inhibition of pathways

    Directory of Open Access Journals (Sweden)

    Charles D. Warden

    2013-09-01

    Full Text Available BD-Func (BiDirectional FUNCtional enrichment is an algorithm that calculates functional enrichment by comparing lists of pre-defined genes that are known to be activated versus inhibited in a pathway or by a regulatory molecule. This paper shows that BD-Func can correctly predict cell line alternations and patient characteristics with accuracy comparable to popular algorithms, with a significantly faster run-time. BD-Func can compare scores for individual samples across multiple groups as well as provide predictive statistics and receiver operating characteristic (ROC plots to quantify the accuracy of the signature associated with a binary phenotypic variable. BD-Func facilitates collaboration and reproducibility by encouraging users to share novel molecular signatures in the BD-Func discussion group, which is where the novel progesterone receptor and LBH589 signatures from this paper can be found. The novel LBH589 signature presented in this paper also serves as a case study showing how a custom signature using cell line data can accurately predict activity in vivo. This software is available to download at https://sourceforge.net/projects/bdfunc/.

  16. Isolation and identification of berberine and berberrubine metabolites by berberine-utilizing bacterium Rhodococcus sp. strain BD7100.

    Science.gov (United States)

    Ishikawa, Kazuki; Takeda, Hisashi; Wakana, Daigo; Sato, Fumihiko; Hosoe, Tomoo

    2016-05-01

    Based on the finding of a novel berberine (BBR)-utilizing bacterium, Rhodococcus sp. strain BD7100, we investigated the degradation of BBR and its analog berberrubine (BRU). Resting cells of BD7100 demethylenated BBR and BRU, yielding benzeneacetic acid analogs. Isolation of benzeneacetic acid analogs suggested that BD7100 degraded the isoquinoline ring of the protoberberine skeleton. This work represents the first report of cleavage of protoberberine skeleton by a microorganism.

  17. Precision Measurement of B(D+ -> mu+ nu) and the Pseudoscalar Decay Constant fD+

    CERN Document Server

    Eisenstein, B I; Mehrabyan, S; Lowrey, N; Selen, M; White, E J; Wiss, J; Mitchell, R E; Shepherd, M R; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Zweber, P; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A G; Libby, J; Martin, L; Powell, A; Wilkinson, G; Ecklund, K M; Love, W; Savinov, V; Méndez, H; Ge, J Y; Miller, D H; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Hu, D; Moziak, B; Napolitano, J; He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Yang, F; Artuso, M; Blusk, S; Khalil, S; Li, J; Menaa, N; Mountain, R; Nisar, S; Randrianarivony, K; Sultana, N; Skwarnicki, T; Stone, S; Wang, J C; Zhang, L M; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Naik, P; Rademacker, J; Asner, D M; Edwards, K W; Reed, J; Briere, R A; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L; Alexander, J P; Cassel, D G; Duboscq, J E; Ehrlich, R; Fields, L; Galik, R S; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Hunt, J M; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Ledoux, J; Mahlke-Krüger, H; Mohapatra, D; Onyisi, P U E; Patterson, J R; Peterson, D; Riley, D; Ryd, A; Sadoff, A J; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Athar, S B; Patel, R; Yelton, J; Rubin, P

    2008-01-01

    We measure the branching ratio of the purely leptonic decay of the D+ meson with unprecedented precision as B(D+ -> mu+ nu) = (3.82 +/- 0.32 +/- 0.09)x10^(-4), using 818/pb of data taken on the psi(3770) resonance with the CLEO-c detector at the CESR collider. We use this determination to derive a value for the pseudoscalar decay constant fD+, combining with measurements of the D+ lifetime and assuming |Vcd| = |Vus|. We find fD+ = (205.8 +/- 8.5 +/- 2.5) MeV. The decay rate asymmetry [B(D+ -> mu+ nu)-B(D- -> mu- nu)]/[B(D+ -> mu+ nu)+B(D- -> mu- nu)] = 0.08 +/- 0.08, consistent with no CP violation. We also set 90% confidence level upper limits on B(D+ -> tau+ nu) e+ nu) < 8.8x10^(-6).

  18. Managing the computational chemistry big data problem: the ioChem-BD platform.

    Science.gov (United States)

    Álvarez-Moreno, M; de Graaf, C; López, N; Maseras, F; Poblet, J M; Bo, C

    2015-01-26

    We present the ioChem-BD platform ( www.iochem-bd.org ) as a multiheaded tool aimed to manage large volumes of quantum chemistry results from a diverse group of already common simulation packages. The platform has an extensible structure. The key modules managing the main tasks are to (i) upload of output files from common computational chemistry packages, (ii) extract meaningful data from the results, and (iii) generate output summaries in user-friendly formats. A heavy use of the Chemical Mark-up Language (CML) is made in the intermediate files used by ioChem-BD. From them and using XSL techniques, we manipulate and transform such chemical data sets to fulfill researchers' needs in the form of HTML5 reports, supporting information, and other research media.

  19. Comparison of positioning accuracy of GPS and BD2 in the South China Sea%南海海域BD2与 GPS定位精度比对

    Institute of Scientific and Technical Information of China (English)

    张永超; 徐国贵; 李帅

    2015-01-01

    The economic benefits of the BD2 are growing .It analysis the positioning difference of GPS and BD2 by using a higher positioning accuracy of GPS receiver and a set of BD 2 e‐quipment which has low power consumption and low cost .The test includes the north and the east of the south China sea .In the test zone ,when positioning accuracy of GPS and BD2 is higher ,the positioning difference of GPS and BD2 is about 3 meters .In the east of the south China sea ,BD2 has been bad in a long time ,but the positioning difference of GPS and BD2 is less than 25 meters .So we can get a conclusion that BD2 can meet the needs of the navigation of ships and position of some M arine equipment .%试验中利用一套定位精度相对较高的G PS设备和一套市场上适用,低功耗、低成本北斗设备,分析G PS和BD2定位差值。所选试验区域包含了南海北部海域和南海东部海域。在这两个区域,当G PS与BD2定位精度较高时,二者定位差值在3m左右。在南海东部海域,BD2出现定位精度不好的情况且时间较长,但定位差值在25m以内。故间接可以说明北斗导航系统能够满足船舶航行以及一些海上仪器设备定位需要。

  20. Folding Behaviour for Proteins BBL and E3BD with Gō-like Models

    Institute of Scientific and Technical Information of China (English)

    ZUO Guang-Hong; ZHANG Jian; WANG Jun; WANG Wei

    2005-01-01

    @@ Folding behaviour of protein BBL and its homologue domain E3BD are studied by using an off-lattice Gō-like model. It is found that the folding behaviours of these two proteins are different. Protein BBL folds in a downhill manner, which is consistent with experiments. In contrast, protein E3BD folds cooperatively and has a bimodal distribution of the Q values (the similarity to the native state). By analysing the native structures of the two proteins, it is found that the difference in folding behaviours can be attributed to the different structural features described by the number of nonlocal contacts per residue.

  1. Clinical Evaluation of the BD FACSPresto™ Near-Patient CD4 Counter in Kenya

    Science.gov (United States)

    Angira, Francis; Akoth, Benta; Omolo, Paul; Opollo, Valarie; Bornheimer, Scott; Judge, Kevin; Tilahun, Henok; Lu, Beverly; Omana-Zapata, Imelda; Zeh, Clement

    2016-01-01

    Background The BD FACSPresto™ Near-Patient CD4 Counter was developed to expand HIV/AIDS management in resource-limited settings. It measures absolute CD4 counts (AbsCD4), percent CD4 (%CD4), and hemoglobin (Hb) from a single drop of capillary or venous blood in approximately 23 minutes, with throughput of 10 samples per hour. We assessed the performance of the BD FACSPresto system, evaluating accuracy, stability, linearity, precision, and reference intervals using capillary and venous blood at KEMRI/CDC HIV-research laboratory, Kisumu, Kenya, and precision and linearity at BD Biosciences, California, USA. Methods For accuracy, venous samples were tested using the BD FACSCalibur™ instrument with BD Tritest™ CD3/CD4/CD45 reagent, BD Trucount™ tubes, and BD Multiset™ software for AbsCD4 and %CD4, and the Sysmex™ KX-21N for Hb. Stability studies evaluated duration of staining (18–120-minute incubation), and effects of venous blood storage <6–24 hours post-draw. A normal cohort was tested for reference intervals. Precision covered multiple days, operators, and instruments. Linearity required mixing two pools of samples, to obtain evenly spaced concentrations for AbsCD4, total lymphocytes, and Hb. Results AbsCD4 and %CD4 venous/capillary (N = 189/ N = 162) accuracy results gave Deming regression slopes within 0.97–1.03 and R2 ≥0.96. For Hb, Deming regression results were R2 ≥0.94 and slope ≥0.94 for both venous and capillary samples. Stability varied within 10% 2 hours after staining and for venous blood stored less than 24 hours. Reference intervals results showed that gender—but not age—differences were statistically significant (p<0.05). Precision results had <3.5% coefficient of variation for AbsCD4, %CD4, and Hb, except for low AbsCD4 samples (<6.8%). Linearity was 42–4,897 cells/μL for AbsCD4, 182–11,704 cells/μL for total lymphocytes, and 2–24 g/dL for Hb. Conclusions The BD FACSPresto system provides accurate, precise clinical

  2. The Unusual Resistance of Avian Defensin AvBD7 to Proteolytic Enzymes Preserves Its Antibacterial Activity

    Science.gov (United States)

    Bailleul, Geoffrey; Kravtzoff, Amanda; Joulin-Giet, Alix; Lecaille, Fabien; Labas, Valérie; Meudal, Hervé; Loth, Karine; Teixeira-Gomes, Ana-Paula; Gilbert, Florence B.; Coquet, Laurent; Jouenne, Thierry; Brömme, Dieter; Schouler, Catherine; Landon, Céline; Lalmanach, Gilles; Lalmanach, Anne-Christine

    2016-01-01

    Defensins are frontline peptides of mucosal immunity in the animal kingdom, including birds. Their resistance to proteolysis and their ensuing ability to maintain antimicrobial potential remains questionable and was therefore investigated. We have shown by bottom-up mass spectrometry analysis of protein extracts that both avian beta-defensins AvBD2 and AvBD7 were ubiquitously distributed along the chicken gut. Cathepsin B was found by immunoblotting in jejunum, ileum, caecum, and caecal tonsils, while cathepsins K, L, and S were merely identified in caecal tonsils. Hydrolysis product of AvBD2 and AvBD7 incubated with a panel of proteases was analysed by RP-HPLC, mass spectrometry and antimicrobial assays. AvBD2 and AvBD7 were resistant to serine proteases and to cathepsins D and H. Conversely cysteine cathepsins B, K, L, and S degraded AvBD2 and abolished its antibacterial activity. Only cathepsin K cleaved AvBD7 and released Ile4-AvBD7, a N-terminal truncated natural peptidoform of AvBD7 that displayed antibacterial activity. Besides the 3-stranded antiparallel beta-sheet typical of beta-defensins, structural analysis of AvBD7 by two-dimensional NMR spectroscopy highlighted the restricted accessibility of the C-terminus embedded by the N-terminal region and gave a formal evidence of a salt bridge (Asp9-Arg12) that could account for proteolysis resistance. The differential susceptibility of avian defensins to proteolysis opens intriguing questions about a distinctive role in the mucosal immunity against pathogen invasion. PMID:27561012

  3. 13 CFR 124.3 - What definitions are important in the 8(a) BD program?

    Science.gov (United States)

    2010-01-01

    ... functions of the firm. Immediate family member means father, mother, husband, wife, son, daughter, brother... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What definitions are important in the 8(a) BD program? 124.3 Section 124.3 Business Credit and Assistance SMALL BUSINESS...

  4. ISO Spectroscopy of Young Intermediate-Mass Stars in the BD+40 4124 Group

    CERN Document Server

    Van den Ancker, M E; Tielens, A G G M

    2000-01-01

    We present the results of ISO SWS and LWS grating scans towards the three brightest members of the BD+40 4124 group in the infrared: BD+40 4124 (B2Ve), LkHalpha 224 (A7e) and the embedded source LkHalpha 225. Emission from the pure rotational lines of H_2, from ro-vibrational transitions of CO, from PAHs, from H I recombination lines and from the infrared fine structure lines of [Fe II], [Si II], [S I], [O I], [O III] and [C II] was detected. These emission lines arise in the combination of a low-density (approx 10^2 cm^-3) H II region with a clumpy PDR in the case of BD+40 4124. The lower transitions of the infrared H I lines observed in BD+40 4124 are optically thick; most likely they arise in either a dense wind or a circumstellar disk. This same region is also responsible for the optical H I lines and the radio continuum emission. In the lines of sight towards LkHalpha 224 and LkHalpha 225, the observed emission lines arise in a non-dissociative shock produced by a slow (approx 20 km/s) outflow arising fr...

  5. Data of evolutionary structure change: 1JJWC-2Z3BD [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1JJWC-2Z3BD 1JJW 2Z3B C D -----TTIVSVRRNGQVVVGGDGQVSLG-NTVMKGNARK...EEE HHHHHHHHHHHHHH HHHHHHHHHHHHHHH EEE 0 1JJ...W C 1JJWC QVSLG-NT...l> 1 1JJW C 1JJ...ne>ILE CA 426 LEU CA 426 ALA CA 469 1JJ

  6. A novel water-soluble benzothiazole derivative BD926 triggers ROS-mediated B lymphoma cell apoptosis via mitochondrial and endoplasmic reticulum signaling pathways.

    Science.gov (United States)

    Li, Min-Hui; Yang, Ping; Yang, Tai; Zhang, Kun; Liu, Yang; Liu, Jin; Li, Li-Mei; Luo, Xing-Yan; Yang, Shu-Xia; Zou, Qiang; Zhang, Chong-Jie

    2016-11-01

    Benzothiazole derivatives are known for various biological activities, and their potency in cancer therapy have received considerable attention in recent years. However, the poor water solubility of most benzothiazole derivatives has limited their clinical application. We developed BD926, a novel water-soluble benzothiazole derivative and showed here that it could inhibit the proliferation and induce apoptosis of human Ramos B-lymphoma cells. We further showed that BD926 triggered apoptosis through both mitochondria and endoplasmic reticulum pathways. Moreover, BD926 caused cell cycle arrest at G0/G1 stage. Furthermore, accumulation of reactive oxygen species (ROS) were observed after BD926 treatment and ROS inhibitor was able to attenuate BD926-induced apoptosis, which suggested that BD926-induced apoptosis may be due to over-producing ROS. These results demonstrate the anticancer effects of BD926 in cell models and raise the possibility for the application of BD926 in cancer therapy.

  7. The orbits of subdwarf-B + main-sequence binaries. II. Three eccentric systems; BD+29 3070, BD +34 1543 and Feige 87

    CERN Document Server

    Vos, J; Nemeth, P; Green, E M; Heber, U; Van Winckel, H

    2013-01-01

    The predicted orbital-period distribution of the subdwarf-B (sdB) population is bi-modal with a peak at short ( 250 days) periods. Observationally, many short-period sdB systems are known, but the predicted long period peak is missing as orbits have only been determined for a few long-period systems. As these predictions are based on poorly understood binary-interaction processes, it is of prime importance to confront the predictions with reliable observational data. We therefore initiated a monitoring program to find and characterize long-period sdB stars. In this paper we aim to determine the orbital parameters of the three long-period sdB+MS binaries BD+29 3070, BD+34 1543 and Feige 87, to constrain their absolute dimensions and the physical parameters of the components. High-resolution spectroscopic time series were obtained with HERMES at the Mercator telescope on La Palma, and analyzed to determine the radial velocities of both the sdB and MS components. Photometry from the literature was used to constr...

  8. Indirect Violation of CP, T and CPT in the Bd-system

    CERN Document Server

    Bañuls, M C

    2001-01-01

    The problem of indirect violation of discrete symmeties CP, T and CPT in a neutral meson system can be described using two complex parameters epsilon and delta, which are invariant under rephasing of meson and quark fields. For the Bd system, where the width difference between the physical states is negligible, only Re(delta) and Im(epsilon) survive. As a consequence, the traditional observables constructed for kaons, which are based on flavour tag, are not useful for the analogous study in this system. We describe how using a CP tag and studying CP-to-flavour transitions of the B mesons, we may build asymmetries, alternative to those used for the kaon, which enable us to test T and CPT invariances of the effective hamiltonian for the Bd system.

  9. Discovery of the benchmark metal poor T8 dwarf BD+01 2920B

    CERN Document Server

    Pinfield, D J; Lodieu, N; Leggett, S K; Tinney, C G; van Spaandonk, L; Marocco, F; Smart, R; Gomes, J; Smith, L; Lucas, P W; Day-Jones, A C; Murray, D N; Katsiyannis, A C; Catalan, S; Cardoso, C; Clarke, J R A; Folkes, S; Galvez-Ortiz, M C; Homeier, D; Jenkins, J S; Jones, H R A; Zhang, Z H

    2012-01-01

    We have searched the WISE first data release for widely separated (<10,000AU) late T dwarf companions to Hipparcos and Gliese stars. We have discovered a new binary system containing a K-band suppressed T8p dwarf WISEP J1423+0116 and the mildly metal poor ([Fe/H]=-0.38+-0.06) primary BD+01 2920 (Hip 70319), a G1 dwarf at a distance of 17.2pc. This new benchmark has Teff=680+-55K and a mass of 20-50 Mjup. Its spectral properties are well modelled except for known discrepancies in the Y and K bands. Based on the well determined metallicity of its companion, the properties of BD+01 2920B imply that the currently known T dwarfs are dominated by young low-mass objects. We also present an accurate proper motion for the T8.5 dwarf WISEP J075003.84+272544.8.

  10. The active source in the region of the Herbig star BD+40 4124.

    Science.gov (United States)

    Palla, F.; Testi, L.; Hunter, T. R.; Taylor, G. B.; Prusti, T.; Felli, M.; Natta, A.; Stanga, R. M.

    1995-01-01

    We present new near-infrared, millimeter and radio observations of the region associated with BD+40 4124, a Herbig Be star located in the direction of the Cygnus arm. BD+40 4124 is the optically brightest member of a small group of young emission line stars, including V 1318 Cygni and V 1686 Cygni. Near-IR broad-band imaging of V 1318 Cygni reveals the presence of two distinct stellar components oriented north-south, a result recently reported by Aspin et al. (1994). On a larger scale, the near-IR images also indicate the presence of many highly embedded sources concentrated in the vicinity of the bright visible stars. In the central part of the cluster, the near-IR sources outnumber the optically visible ones by a factor of three. The distribution of the high density molecular gas traced by the CS J=5->4 emission is highly concentrated around V1318 and V1686 Cygni, while the total column density of gas traced by the C^18^O J=2->1 shows a ridge morphology centered on these sources. The Herbig star BD+40 4124lies at the edge of both structures. From the otpically thin C^18^O emission, we derive a total molecular mass of M_core_=280Msun_. A molecular outflow has been detected in CO J=2->1. The high velocity gas is confined to a compact region of size =~20", corresponding to a physical length of 0.1pc. The outflow is not well resolved, or collimated, on the observed scales. We have also detected H_2_O maser emission at 22.2GHz at a position coincident with the center of the bipolar outflow. Both the maser and the outflow are located at the position of the southern source V1318 S which we identify as the source responsible for the activity observed in the BD+40 region.

  11. Transformation of Acinetobacter sp. strain BD413 by transgenic sugar beet DNA.

    Science.gov (United States)

    Gebhard, F; Smalla, K

    1998-04-01

    The ability of Acinetobacter sp. strain BD413(pFG4 delta nptII) to take up and integrate transgenic plant DNA based on homologous recombination was studied under optimized laboratory conditions. Restoration of nptII, resulting in kanamycin-resistant transformants, was observed with plasmid DNA, plant DNA, and homogenates carrying the gene nptII. Molecular analysis showed that some transformants not only restored the 317-bp deletion but also obtained additional DNA.

  12. BD LSRFortessa for Tulane DoD ID and Cancer Projects

    Science.gov (United States)

    2015-01-21

    ACCOUNTS PAYABLE 1430 TULANE AVE NEW ORLEANS LA 70112 BD Biosclences 2350 Qume Drive San Jose,CA 95131-1807 USA Tel: 1-877-232-8995 EIN: 22...SHIP-TO ADDRESS TULANE UN IV MEDICAL CENTER TULANE UN IV MEDICAL CENTER ACCOUNTS PAYABLE ATTN JAMES MCLACHLAN 1430 TULANE AVE 1430 TULANE AVE NEW...NO : 2000033956 SOLD-TO ADDRESS SHIP-TO ADDRESS TULANE UN IV MEDICAL CENTER TULANE UNIV MEDICAL CENTER ACCOUNTS PAYABLE ATIN JAMES MCLACHLAN 1430

  13. Mixing and CP violation in the Bd and Bs systems at ATLAS

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00229256; The ATLAS collaboration

    2016-01-01

    This note includes a measurement of the $B^0_s$ decay parameters in the $ B_s \\rightarrow J/\\psi$ channel and a measurement of the $B_d$ meson using the statistics collected by the ATLAS experiment in Run I of the LHC. The first result presents the measurement of the $CP$-violating phase $\\phi_s$, the decay width $\\Gamma_s$ and the width difference between the mass eigenstates $\\Delta \\Gamma_s$. The second result presents the measurement of the width difference $\\Delta \\Gamma_d$, which is extracted from the measurement of the lifetime dependence of $B_d \\to J/\\psi K_S$ and $B_d \\to J/\\psi K^{*0}$ decays. The obtained results are $\\phi_s = −0.098 \\pm 0.084 (\\textrm{stat.}) \\pm 0.040 (\\textrm{syst.})$ rad. and $\\Delta \\Gamma_d / \\Gamma_d = (-0.1 \\pm 1.1 (\\textrm{stat.}) \\pm 0.9 (\\textrm{syst.}))\\times 10^{-2}$.

  14. The mysterious sdO X-ray binary BD+37 442

    CERN Document Server

    Heber, U; Irrgang, A; Schneider, D; Barbu-Barna, I; Mereghetti, S; La Palombara, N

    2014-01-01

    Pulsed X-ray emission in the luminous, helium-rich sdO BD+37 442 has recently been discovered (La Palombara et al., 2012). It was suggested that the sdO star has a neutron star or white dwarf companion with a spin period of 19.2 s. After HD 49798, which has a massive white dwarf companion spinning at 13.2 s in an 1.55 day orbit, this is only the second O-type subdwarf from which X-ray emission has been detected. We report preliminary results of our ongoing campaign to obtain time-resolved high-resolution spectroscopy using the CAFE instrument at Calar Alto observatory and SARG at the Telescopio Nationale Galileo. Atmospheric parameters were derived via a quantitative NLTE spectral analysis. The line fits hint at an unusually large projected rotation velocity. Therefore it seemed likely that BD+37 442 is a binary similar to HD 49798 and that the orbital period is also similar. The level of X-ray emission from BD+37 442 could be explained by accretion from the sdO wind by a neutron star orbiting at a period of ...

  15. Chemical Analysis of the Ninth Magnitude Carbon-Enhanced Metal-Poor Star BD+44 493

    CERN Document Server

    Ito, H; Beers, T C; Tominaga, N; Honda, S

    2013-01-01

    We present detailed chemical abundances for the bright carbon-enhanced metal-poor (CEMP) star BD+44 493, previously reported on by Ito et al. Our measurements confirm that BD+44 493 is an extremely metal-poor ([Fe/H]=-3.8) subgiant star with excesses of carbon and oxygen. No significant excesses are found for nitrogen and neutron-capture elements (the latter of which place it in the CEMP-no class of stars). Other elements that we measure exhibit abundance patterns that are typical for non-CEMP extremely metal-poor stars. No evidence for variations of radial velocity have been found for this star. These results strongly suggest that the carbon enhancement in BD+44 493 is unlikely to have been produced by a companion asymptotic giant-branch star and transferred to the presently observed star, nor by pollution of its natal molecular cloud by rapidly-rotating, massive, mega metal-poor ([Fe/H] < -6.0) stars. A more likely possibility is that this star formed from gas polluted by the elements produced in a "fain...

  16. Identification and characterization of the RouenBd1987 Babesia divergens Rhopty-Associated Protein 1.

    Directory of Open Access Journals (Sweden)

    Marilis Rodriguez

    Full Text Available Human babesiosis is caused by one of several babesial species transmitted by ixodid ticks that have distinct geographical distributions based on the presence of competent animal hosts. The pathology of babesiosis, like malaria, is a consequence of the parasitaemia which develops through the cyclical replication of Babesia parasites in a patient's red blood cells, though symptoms typically are nonspecific. We have identified the gene encoding Rhoptry-Associated Protein -1 (RAP-1 from a human isolate of B. divergens, Rouen1987 and characterized its protein product at the molecular and cellular level. Consistent with other Babesia RAP-1 homologues, BdRAP-1 is expressed as a 46 kDa protein in the parasite rhoptries, suggesting a possible role in red cell invasion. Native BdRAP-1 binds to an unidentified red cell receptor(s that appears to be non-sialylated and non-proteinacious in nature, but we do not find significant reduction in growth with anti-rRAP1 antibodies in vitro, highlighting the possibility the B. divergens is able to use alternative pathways for invasion, or there is an alternative, complementary, role for BdRAP-1 during the invasion process. As it is the parasite's ability to recognize and then invade host cells which is central to clinical disease, characterising and understanding the role of Babesia-derived proteins involved in these steps are of great interest for the development of an effective prophylaxis.

  17. A NLTE analysis of the hot subdwarf O star Bd+28 4211. I. The UV spectrum

    CERN Document Server

    Latour, M; Chayer, P; Brassard, P

    2013-01-01

    We present a detailed analysis of the UV spectrum of the calibration star Bd+28 4211 using high-quality spectra obtained with the HST and FUSE satellites. To this aim, we compare quantitatively the observed data with model spectra obtained from state-of-the-art NLTE metal line-blanketed model atmospheres and synthetic spectra calculated with TLUSTY and SYNSPEC. We thus determine in a self-consistent way the abundances of eleven elements with well-defined lines in the UV, namely those of C, N, O, F, Mg, Si, P, S, Ar, Fe, and Ni. The derived abundances range from about solar to 1/10 solar. We find that the overall quality of the derived spectral fits is very satisfying. Our spectral analysis can be used to constrain rather tigthly the effective temperature of Bd+28 to a value of teff = 82,000 +/- 5000 K. We also estimate conservatively that its surface gravity falls in the range log g = 6.2 -0.1/+0.3. Assuming that the Hipparcos measurement for Bd+28 is fully reliable and that our model atmospheres are reasonab...

  18. Down-regulation of BdBRI1, a putative brassinosteroid receptor gene produces a dwarf phenotype with enhanced drought tolerance in Brachypodium distachyon.

    Science.gov (United States)

    Feng, Ying; Yin, Yanhai; Fei, Shuizhang

    2015-05-01

    Brassinosteroids (BRs) play important roles in plant growth, development and responses to a range of environmental cues. Although the mechanism of how BRs regulate growth and development is well-understood in Arabidopsis, the effect of BRs on stress tolerance, particularly drought tolerance remains unknown. We isolated a BRI1 (BRASSINOSTEROID INSENSITIVE 1) homologous gene, BdBRI1 from Brachypodium distachyon, a model for temperate grasses and cereals, created and characterized RNA interference (RNAi) knockdown mutants for BdBRI1 in Brachypodium. The loss-of-function BdBRI1-RNAi mutants exhibited reduced plant height, shortened internodes, narrow and short leaf, and reduced expression of BR signaling genes, BdBES1, BdBZR1, BdBLE2, and enhanced expression of BR biosynthesis genes BdD2, BdCPD and BdDWF4. More importantly, BdBRI1 RNAi mutants exhibited enhanced drought tolerance, accompanied by highly elevated expression of drought-responsive genes, BdP5CS, BdCOR47/BdRD17, together with BdERD1 and BdRD26, two putative targets of the transcription factors BES1 and BZR1 that are key components of the BR signaling pathway. Our results suggest that BR signaling and biosynthesis are largely conserved among Arabidopsis, rice and Brachypodium, and that BR signaling plays an important role in drought tolerance by directly regulating expression of key drought-responsive genes. The effect of BR biosynthesis or crosstalks between BR and other hormones or components of stress signaling pathways on drought tolerance is discussed.

  19. Detection of Trichomonas vaginalis DNA by use of self-obtained vaginal swabs with the BD ProbeTec Qx assay on the BD Viper system.

    Science.gov (United States)

    Van Der Pol, Barbara; Williams, James A; Taylor, Stephanie N; Cammarata, Catherine L; Rivers, Charles A; Body, Barbara A; Nye, Melinda; Fuller, Deanna; Schwebke, Jane R; Barnes, Mathilda; Gaydos, Charlotte A

    2014-03-01

    Trichomonas vaginalis is the most prevalent nonviral sexually transmitted infection worldwide, and improved diagnostic methods are critical for controlling this pathogen. Diagnostic assays that can be used in conjunction with routine chlamydia/gonorrhea nucleic acid-based screening are likely to have the most impact on disease control. Here we describe the performance of the new BD T. vaginalis Qx (TVQ) amplified DNA assay, which can be performed on the automated BD Viper system. We focus on data from vaginal swab samples, since this is the specimen type routinely used for traditional trichomonas testing and the recommended specimen type for chlamydia/gonorrhea screening. Vaginal swabs were obtained from women attending sexually transmitted disease or family planning clinics at 7 sites. Patient-collected vaginal swabs were tested by the TVQ assay, and the Aptima T. vaginalis (ATV) assay was performed using clinician-collected vaginal swabs. Additional clinician-collected vaginal swabs were used for the wet mount and culture methods. Analyses included comparisons versus the patient infection status (PIS) defined by positive results with the wet mount method or culture, direct comparisons assessed with κ scores, and latent class analysis (LCA) as an unbiased estimator of test accuracy. Data from 838 women, 116 of whom were infected with T. vaginalis, were analyzed. The TVQ assay sensitivity and specificity estimates based on the PIS were 98.3% and 99.0%, respectively. The TVQ assay was similar to the ATV assay (κ=0.938) in direct analysis. LCA estimated the TVQ sensitivity and specificity as 98.3 and 99.6%, respectively. The TVQ assay performed well using self-collected vaginal swabs, the optimal sample type, as recommended by the CDC for chlamydia/gonorrhea screening among women.

  20. Comparison of Allergenicity at Gly m 4 and Gly m Bd 30K of Soybean after Genetic Modification.

    Science.gov (United States)

    Tsai, Jaw-Ji; Chang, Ching-Yun; Liao, En-Chih

    2017-02-15

    Despite rapid growth of genetically modified (GM) crops, effective evaluations of genetic modification on allergenicity are still lacking. Gly m Bd 30K is cross-reactive with cow's milk protein casein, Gly m 4, and with birch pollen allergen Bet v 1. Here we compared the allergenicity between GM and non-GM soybeans with respect to the foci Gly m 4 and Gly m Bd 30K. Recombinant allergens of Gly m Bd 30K and Gly m 4 were generated and polyclonal antibodies raised to identify these two allergenic components in soybeans. GM soybean was first PCR-confirmed using 35S promoter. A total of 20 soybeans (half GM, half non-GM) obtained from a food market were used to assess their allergenicity based on IgE-binding and histamine release. The concentrations of Gly m Bd 30K and Gly m 4 in soybeans were then determined. Most soybean-allergic patients (9 of 10) showed IgE-positive reactions to the allergen of 30 kDa in molecular weight. That allergen turned out to be Glycine max Gly m Bd 30K based on LC-MS/MS analyses. Gly m Bd 30K is therefore the major allergen in the soybean. An increase in the transcription of both the Gly m 4 (stress-induced protein SAM22) and Gly m Bd 28K (soybean allergen precursor) was found after genetic modification. The protein concentrations of Gly m 4 and Gly m Bd 30K were not statistically significant different between non-GM and GM soybeans. There were also no statistical significances between them in the tests of IgE binding and histamine release. In conclusion, soybeans showed similar concentrations of Gly m Bd 30K and Gly m 4 regardless of genetic modification or absence thereof. The allergenicity of both Gly m Bd 30K and Gly m 4 was therefore not altered after genetic modification. Patients showing hypersensitivity to soybeans and who had pre-existing allergy to birch pollen and cow's milk casein might not further increase their allergic reactions following exposures to the GM soybeans.

  1. Use of the BD-100R as a neutron spectrometer through applied pressure variation

    Energy Technology Data Exchange (ETDEWEB)

    White, B.; Ebert, D.; Munno, F. (Univ. of Maryland, College Park (USA))

    1991-05-01

    A study was undertaken to demonstrate the feasibility of using the well-characterized BD-100R neutron bubble dosimeter as a neutron spectrometer in low-level radiation fields. The BD-100R dosimeters used in this work consisted of a test tube containing an elastic polymer with interspersed droplets of two types of Freon: Freon-12 and Freon-114. Each superheated liquid droplet is a potential nucleation site, with the minimum energy needed to form a bubble at the nucleation site being inversely proportional to the square of the difference between the applied and the vapor pressure (i.e., Emin alpha(delta P)-2). For a given dose, the number of bubbles formed continually decreases with increasing applied pressure, until a pressure is reached where no bubbles are formed, since the energy transferred can no longer vaporize the Freon. This investigation is intended to demonstrate the feasibility of measuring an unknown spectrum utilizing the dosimeter response (number of bubbles formed) as a function of the neutron energy (applied pressure). A set of 12 dosimeters was exposed under various applied pressures in a well-characterized neutron energy spectrum at the East Beam Port (EBP) of the Maryland University Training Reactor (MUTR). The dosimeters were placed inside a pressure chamber that could accommodate up to 18 dosimeters. Energy response coefficients (cross-sections) were obtained by spectral unfolding techniques on the known spectrum. The same set of dosimeters were then irradiated using a paraffin-moderated Pu/Be source. Measured spectral estimates obtained using the response coefficients were compared with numerical computations generated using the ANISN computer code. The results indicate that further research using the BD-100R as a neutron spectrometer in low radiation fields is warranted.

  2. The Bifidobacterium dentium Bd1 genome sequence reflects its genetic adaptation to the human oral cavity.

    Directory of Open Access Journals (Sweden)

    Marco Ventura

    2009-12-01

    Full Text Available Bifidobacteria, one of the relatively dominant components of the human intestinal microbiota, are considered one of the key groups of beneficial intestinal bacteria (probiotic bacteria. However, in addition to health-promoting taxa, the genus Bifidobacterium also includes Bifidobacterium dentium, an opportunistic cariogenic pathogen. The genetic basis for the ability of B. dentium to survive in the oral cavity and contribute to caries development is not understood. The genome of B. dentium Bd1, a strain isolated from dental caries, was sequenced to completion to uncover a single circular 2,636,368 base pair chromosome with 2,143 predicted open reading frames. Annotation of the genome sequence revealed multiple ways in which B. dentium has adapted to the oral environment through specialized nutrient acquisition, defences against antimicrobials, and gene products that increase fitness and competitiveness within the oral niche. B. dentium Bd1 was shown to metabolize a wide variety of carbohydrates, consistent with genome-based predictions, while colonization and persistence factors implicated in tissue adhesion, acid tolerance, and the metabolism of human saliva-derived compounds were also identified. Global transcriptome analysis demonstrated that many of the genes encoding these predicted traits are highly expressed under relevant physiological conditions. This is the first report to identify, through various genomic approaches, specific genetic adaptations of a Bifidobacterium taxon, Bifidobacterium dentium Bd1, to a lifestyle as a cariogenic microorganism in the oral cavity. In silico analysis and comparative genomic hybridization experiments clearly reveal a high level of genome conservation among various B. dentium strains. The data indicate that the genome of this opportunistic cariogen has evolved through a very limited number of horizontal gene acquisition events, highlighting the narrow boundaries that separate commensals from

  3. BD30AV—HD系列数字高清延时器

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    B&M MODERN MEDIA INC.为广播级视音频用户推出的高端数字高、标清信号处理产品系列—BD30AV—HD系列高清数字延时器.兼容数字HD—SDI和SD—SDI嵌入式信号,支持各种HD/SD信号格式。可选HD—SDI信号的延时时间最长为120秒,或SD—SDI信号的延时时间最长达720秒,

  4. An evaluation of the BD-100R rechargeable neutron bubble dosimeter

    Energy Technology Data Exchange (ETDEWEB)

    Millett, M.; Munno, F.; Ebert, D.; Nelson, M. (Univ. of Maryland, College Park (USA))

    1991-03-01

    The purpose of this paper is to present data gathered in the evaluation of the BD-100R neutron bubble dosimeter done at the University of Maryland and the Naval Research Lab. The performance of 12 dosimeters has been followed over 15 exposure-recharge cycles under a wide range of exposure conditions. Included in this paper are the results from tests on dose rate dependence, neutron energy dependence, beta and gamma exposure, and recharge cycle performance. A statistical analysis of the reusability performance of the dosimeter as a function of dose equivalent is also presented.

  5. Jofre de Foixa, “Subrafusa ab cabirol” (BdT 304.4

    Directory of Open Access Journals (Sweden)

    Wendy Pfeffer

    2011-11-01

    Full Text Available Jofre de Foixa’s verses “Subrafusa ab cabirol” (BdT 304.4 merit attention for the light the two ‘coblas’ shed on Jofre’s familiarity with his Occitan predecessors, for the information the text provides regarding food practices in his time, and for the use of a food term rare in the Iberian peninsula, “unyo”. The resources of culinary history, specifically fourteenth- and fifteenth-century Languedocian and Catalan cookbooks, allow us better to understand the meaning of Jofre’s lyric.

  6. BD-22deg3467, a DAO-type Star Exciting the Nebula Abell 35

    Science.gov (United States)

    Ziegler, M.; Rauch, T.; Werner, K.; Koppen, J.; Kruk, J. W.

    2013-01-01

    Spectral analyses of hot, compact stars with non-local thermodynamical equilibrium (NLTE) model-atmosphere techniques allow the precise determination of photospheric parameters such as the effective temperature (T(sub eff)), the surface gravity (log g), and the chemical composition. The derived photospheric metal abundances are crucial constraints for stellar evolutionary theory. Aims. Previous spectral analyses of the exciting star of the nebula A35, BD-22deg3467, were based on He+C+N+O+Si+Fe models only. For our analysis, we use state-of-the-art fully metal-line blanketed NLTE model atmospheres that consider opacities of 23 elements from hydrogen to nickel. We aim to identify all observed lines in the ultraviolet (UV) spectrum of BD-22deg3467 and to determine the abundances of the respective species precisely. Methods. For the analysis of high-resolution and high signal-to-noise ratio (S/N) far-ultraviolet (FUSE) and UV (HST/STIS) observations, we combined stellar-atmosphere models and interstellar line-absorption models to fully reproduce the entire observed UV spectrum. Results. The best agreement with the UV observation of BD-22deg3467 is achieved at T(sub eff) = 80 +/- 10 kK and log g = 7.2 +/- 0.3. While T(sub eff) of previous analyses is verified, log g is significantly lower. We re-analyzed lines of silicon and iron (1/100 and about solar abundances, respectively) and for the first time in this star identified argon, chromium, manganese, cobalt, and nickel and determined abundances of 12, 70, 35, 150, and 5 times solar, respectively. Our results partially agree with predictions of diffusion models for DA-type white dwarfs. A combination of photospheric and interstellar line-absorption models reproduces more than 90% of the observed absorption features. The stellar mass is M approx. 0.48 Solar Mass. Conclusions. BD.22.3467 may not have been massive enough to ascend the asymptotic giant branch and may have evolved directly from the extended horizontal branch

  7. Mannans and endo-β-mannanases (MAN) in Brachypodium distachyon: expression profiling and possible role of the BdMAN genes during coleorhiza-limited seed germination.

    Science.gov (United States)

    González-Calle, Virginia; Barrero-Sicilia, Cristina; Carbonero, Pilar; Iglesias-Fernández, Raquel

    2015-07-01

    Immunolocalization of mannans in the seeds of Brachypodium distachyon reveals the presence of these polysaccharides in the root embryo and in the coleorhiza in the early stages of germination (12h), decreasing thereafter to the point of being hardly detected at 27h. Concurrently, the activity of endo-β-mannanases (MANs; EC 3.2.1.78) that catalyse the hydrolysis of β-1,4 bonds in mannan polymers, increases as germination progresses. The MAN gene family is represented by six members in the Brachypodium genome, and their expression has been explored in different organs and especially in germinating seeds. Transcripts of BdMAN2, BdMAN4 and BdMAN6 accumulate in embryos, with a maximum at 24-30h, and are detected in the coleorhiza and in the root by in situ hybridization analyses, before root protrusion (germination sensu stricto). BdMAN4 is not only present in the embryo root and coleorhiza, but is abundant in the de-embryonated (endosperm) imbibed seeds, while BdMAN2 and BdMAN6 are faintly expressed in endosperm during post-germination (36-42h). BdMAN4 and BdMAN6 transcripts are detected in the aleurone layer. These data indicate that BdMAN2, BdMAN4 and BdMAN6 are important for germination sensu stricto and that BdMAN4 and BdMAN6 may also influence reserve mobilization. Whether the coleorhiza in monocots and the micropylar endosperm in eudicots have similar functions, is discussed.

  8. BD +44 493: A Ninth Magnitude Messenger from the Early Universe; Carbon Enhanced and Beryllium Poor

    CERN Document Server

    Ito, Hiroko; Honda, Satoshi; Beers, Timothy C

    2009-01-01

    We present a 1D LTE chemical abundance analysis of the very bright (V=9.1) Carbon-Enhanced Metal-Poor (CEMP) star BD +44 493, based on high-resolution, high signal-to-noise spectra obtained with Subaru/HDS. The star is shown to be a subgiant with an extremely low iron abundance ([Fe/H]=-3.7), while it is rich in C ([C/Fe]=+1.3) and O ([O/Fe]=+1.6). Although astronomers have been searching for extremely metal-poor stars for decades, this is the first star found with [Fe/H]<-3.5 and an apparent magnitude V<12. Based on its low abundances of neutron-capture elements (e.g., [Ba/Fe]=-0.59), BD +44 493 is classified as a "CEMP-no" star. Its abundance pattern implies that a first-generation faint supernova is the most likely origin of its carbon excess, while scenarios related to mass loss from rapidly-rotating massive stars or mass transfer from an AGB companion star are not favored. From a high-quality spectrum in the near-UV region, we set an very low upper limit on this star's beryllium abundance (A(Be)=lo...

  9. Re (epsilon'/epsilon_K) vs. B_d -> phi K_S CP asymmetry

    CERN Document Server

    Ko, P; Park, J; Park, Jae-hyeon

    2005-01-01

    In a SUSY GUT seesaw scenario, the largeness of the atmospheric neutrino mixing can reflect itself into an enhanced flavor changing mixing of beauty and strange right-handed scalar quarks. If the CP violating phase in such down type squark RR insertion is the main source of CP asymmetry in B_d -> phi K_S and the gluino contributions to K0-K0 bar and B0-B0 bar mixing are negligible, there is a correlation between Re (epsilon'/epsilon_K) and B_d -> phi K_S CP asymmetry, in addition to that with the strange quark CEDM. The current data on Re (epsilon'/epsilon_K) = (16.7 +- 2.6) 10^-4 imply that S_{phi K} should be greater than \\sim 0.5 (0.25) for mu tan beta = 1 (5) TeV, assuming the RR dominance in b -> s transition and the minimal supergravity type boundary conditions for soft parameters.

  10. A NLTE analysis of the hot subdwarf O star BD+28 4211. II. The optical spectrum

    CERN Document Server

    Latour, M; Green, E M; Brassard, P

    2015-01-01

    We present the second part of our detailed analysis of the hot sdO and spectroscopic standard star BD+28 4211, in which we focus on the optical spectrum. In the first part of our study, we determined the abundances of some 11 metals detected in the atmosphere of BD+28 4211 using UV spectra of the star and corroborated the fundamental parameters estimated in past studies (Teff $\\sim$ 82,000 K, log g $\\sim$ 6.2, and solar N(He)/N(H)). In this work, we aim at rederiving these secured parameters on the sole basis of high-quality optical spectra. A first grid of non-LTE line-blanketed model atmospheres, including metals with the abundances derived from the UV spectrum, does not give satisfactory results when we apply a standard simultaneous fitting procedure to the observed H and He lines of our optical spectra. The line profiles are not finely reproduced and the resulting effective temperatures, in particular, are too low by $\\sim$10,000 K. We next investigate the probable cause of this failure, that is, the impo...

  11. Albertet, “Donna pros e richa” (BdT 16.11

    Directory of Open Access Journals (Sweden)

    Francesca Sanguineti

    2009-11-01

    Full Text Available This paper will provide a commentary and a new critical edition of “Donna pros e richa” by Albertet, a poem with an exceptional metrical structure, halfway between a ‘canso’ and an isostrophic ‘descort’. Its structure is identical to Raimbaut de Vaqueiras’ “Carros” (BdT 392.32: most likely Albertet’s poem is the original while “Truan, mala guerra” is a contrafactum, considering the fact that it is comparable to a sirventes. The lyric self urgently requests the love of a Genoese lady, complaining of her indifference and cursing her quite violently at the end of each stanza. The passionate tone that characterizes the poem becomes less so towards the end where God is finally called upon to protect the lady. What is clear here is, on the one hand, the poem’s conformity with the characteristics of the ‘mala canso’, and, on the other, its similarity with another poem by Raimbaut de Vaqueiras, the ‘contrasto’ with the Genoese lady (BdT 392.7. Thus Albertet’s poem is curious from different points of view: for its metrical form, uncommon in a ‘canso’; for its linguistic register which ressembles that of narrative genres such as the ‘fabliaux’; for its rhymes which offer a series of analogies and exchanges of rhyme-words with the two Raimbauts, the previously mentioned Raimbaut de Vaqueiras and Raimbaut d’Aurenga.

  12. BD-22 3467, a DAO-type star exciting the nebula Abell 35

    CERN Document Server

    Ziegler, M; Werner, K; Koeppen, J; Kruk, J W

    2012-01-01

    Spectral analyses of hot, compact stars with NLTE (non-local thermodynamical equilibrium) model-atmosphere techniques allow the precise determination of photospheric parameters. The derived photospheric metal abundances are crucial constraints for stellar evolutionary theory. Previous spectral analyses of the exciting star of the nebula A 35, BD-22 3467, were based on He+C+N+O+Si+Fe models only. For our analysis, we use state-of-the-art fully metal-line blanketed NLTE model atmospheres that consider opacities of 23 elements from hydrogen to nickel. For the analysis of high-resolution and high-S/N (signal-to-noise) FUV (far ultraviolet, FUSE) and UV (HST/STIS) observations, we combined stellar-atmosphere models and interstellar line-absorption models to fully reproduce the entire observed UV spectrum. The best agreement with the UV observation of BD-22 3467 is achieved at Teff = 80 +/- 10 kK and log g =7.2 +/- 0.3. While Teff of previous analyses is verified, log g is significantly lower. We re-analyzed lines ...

  13. Detection of Phosphorus, Sulphur, and Zinc in the Carbon-Enhanced Metal-Poor Star BD+44 493

    CERN Document Server

    Roederer, Ian U; Beers, Timothy C

    2016-01-01

    The carbon-enhanced metal-poor star BD+44 493 ([Fe/H]=-3.9) has been proposed as a candidate second-generation star enriched by metals from a single Pop III star. We report the first detections of P and S and the second detection of Zn in any extremely metal-poor carbon-enhanced star, using new spectra of BD+44 493 collected by the Cosmic Origins Spectrograph on the Hubble Space Telescope. We derive [P/Fe]=-0.34 +/- 0.21, [S/Fe]=+0.07 +/- 0.41, and [Zn/Fe]=-0.10 +/- 0.24. We increase by ten-fold the number of Si I lines detected in BD+44 493, yielding [Si/Fe]=+0.15 +/- 0.22. The solar [S/Fe] and [Zn/Fe] ratios exclude the hypothesis that the abundance pattern in BD+44 493 results from depletion of refractory elements onto dust grains. Comparison with zero-metallicity supernova models suggests that the stellar progenitor that enriched BD+44 493 was massive and ejected much less than 0.07 Msun of Ni-56, characteristic of a faint supernova.

  14. Recombination and Fusion Expression of Porcine Defensin Gene pBD-2 in E.Coli%猪防御素基因pBD-2在大肠杆菌中的重组和融合表达

    Institute of Scientific and Technical Information of China (English)

    徐海涛; 马立保; 何启盖; 廖冰麟; 任芬芬

    2011-01-01

    哺乳动物防御素是动物机体在抵御病原微生物的防御反应中产生的一类重要的抗菌肽物质,具有十分广泛的抗菌谱,在先天免疫上起重要作用.本研究根据已报道的pBD-2基因cDNA序列,合成了3条基因片段(1、2、3).片段1、2和片段2、3各有15个碱基互补配对,PCR扩增延伸得到pBD-2基因,将pBD-2基因克隆至原核表达载体pGEX-KG,成功地在大肠杆菌BL21(DE3)中表达出pBD-2融合蛋白.pBD-2基因的成功表达为进一步研究其抗菌活性打下了基础.%Defensin is an important antimicrobial peptide produced in the course of animals' defense against pathogens,which has a broad antibacterial spectrum and plays an important role in innate immunity. Based on cDNA sequence of porcine defensin βdefensin 2 gene reported in this study, three gene fragment (1,2,3) were synthesized in this experiment. Fragment 1,2 and fragment 2,3 had respectively 15 bases for complementary pair. pBD-2 gene was produced by PCR amplifing, and pBD-2 was inserted into expression vector (pGEX-KG) and recombinant vector transformed into E.coli, where recombinant vector produced fusion protein successfully. The expression of pBD-2 gene lays a foundation in research on antimicrobial activities of defensin.

  15. Sigma-1 receptor antagonist, BD1047 reduces nociceptive responses and phosphorylation of p38 MAPK in mice orofacial formalin model.

    Science.gov (United States)

    Roh, Dae-Hyun; Yoon, Seo-Yeon

    2014-01-01

    Sigma-1 receptors (Sig-1Rs) play a role in different types of pain and in central sensitization mechanism in spinal cord. However, it is currently unexplored whether Sig-1Rs are involved in orofacial pain processing. Here we show whether a selective Sig-1R antagonist, BD1047 reduces nociceptive responses in the mouse orofacial formalin model and the number of Fos-immunoreactive (ir) cells in the trigeminal nucleus caudalis (TNC). In addition, it was examined whether the phosphorylation of extracellular signal-regulated kinase (pERK) or p38 (pp38) mitogen-activated protein kinases (MAPK), which are closely linked to pain signaling and sensitization, in TNC was modified by BD1047. The 5% formalin (10 µL) was subcutaneously injected into the right upper lip, and the rubbing responses with ipsilateral fore- or hind paw were counted for 45 min. BD1047 (1, 3 or 10 mg/kg) were intraperitoneally treated 30 min before formalin injection. High dose of BD1047 (10 mg/kg) produced significant anti-nociceptive effects in the first and the second phase. The number of Fos-ir cells in ipsilateral side of TNC was also reduced by BD1047 as compared to that in saline-treated animals. In addition, the number of pp38-ir cells in ipsilateral TNC was decreased in BD1047-treated animals, whereas the number of pERK-ir cells was not modified. Collectively, these results demonstrate that Sig-1Rs play a pivotal role in the orofacial pain processing, and the pp38 signaling pathway can be associated with Sig-1R's action in TNC.

  16. Properties of the B+-H2 and B+-D2 complexes: A theoretical and spectroscopic study

    Science.gov (United States)

    Poad, B. L. J.; Dryza, V.; Buchachenko, A. A.; Kłos, J.; Bieske, E. J.

    2012-09-01

    The rotationally resolved infrared spectrum of the B+-D2 ion-neutral complex is recorded in the D-D stretch vibration region (2805-2875 cm-1) by detecting B+ photofragments. Analysis of the spectrum confirms a T-shaped equilibrium geometry for the B+-D2 complex with a vibrationally averaged intermolecular bond length of 2.247 Å, around 0.02 Å shorter than for the previously characterised B+-H2 complex [V. Dryza, B. L. J. Poad, and E. J. Bieske, J. Am. Chem. Soc. 130, 12986 (2008), 10.1021/ja8018302]. The D-D stretch band centre occurs at 2839.76 ± 0.10 cm-1, representing a -153.8 cm-1 shift from the Q1(0) transition of the free D2 molecule. A new three dimensional ab initio potential energy surface for the B++H2 interaction is calculated using the coupled cluster RCCSD(T) method and is used in variational calculations for the rovibrational energies of B+-H2 and B+-D2. The calculations predict dissociation energies of 1254 cm-1 for B+-H2 with respect to the B++H2 (j = 0) limit, and 1313 cm-1 for B+-D2 with respect to the B++D2 (j = 0) limit. The theoretical approach reproduces the rotational and centrifugal constants of the B+-H2 and B+-D2 complexes to within 3%, and the magnitude of the contraction of the intermolecular bond accompanying excitation of the H2 or D2 sub-unit, but underestimates the H-H and D-D vibrational band shifts by 7%-8%. Combining the theoretical and experimental results allows a new, more accurate estimation for the B+-H2 band origin (3939.64 ± 0.10 cm-1).

  17. OSAKA Trial: A Randomized, Controlled Trial Comparing Tacrolimus QD and BD in Kidney Transplantation

    Science.gov (United States)

    Albano, Laetitia; Banas, Bernhard; Klempnauer, Juergen L.; Glyda, Maciej; Viklicky, Ondrej; Kamar, Nassim

    2013-01-01

    Background The once-daily (QD), prolonged-release formulation of tacrolimus has been shown to improve adherence versus twice-daily (BD) tacrolimus. Treatment nonadherence in transplant recipients has been associated with poor graft outcomes. Methods This open-label, parallel-group study randomized adults with end-stage renal disease undergoing primary kidney transplantation or retransplantation to an initial dose of tacrolimus BD 0.2 mg/kg per day (Arm 1; n=309), QD 0.2 mg/kg per day (Arm 2; n=302), QD 0.3 mg/kg per day (Arm 3; n=304) all with mycophenolate mofetil and corticosteroids (tapered) over 24 weeks, or tacrolimus QD 0.2 mg/kg per day with mycophenolate mofetil, basiliximab, and corticosteroids given only perioperatively (Arm 4; n=283). The primary composite endpoint (efficacy failure; per protocol set) was defined as graft loss, biopsy-confirmed acute rejection, or graft dysfunction at week 24. Graft dysfunction was defined as estimated glomerular filtration rate Modification of Diet in Renal Disease-4 formula of less than 40 mL/min/1.73 m2. The prespecified noninferiority margin was 12.5%. Results The per protocol set included 976 patients: 237, 263, 246, and 230 patients in Arms 1 to 4, respectively. Noninferiority of the composite endpoint was demonstrated for Arm 2 versus Arm 1; Kaplan–Meier estimates of efficacy failure were 42.2% and 40.6%, respectively (difference, −1.6%; 95% confidence interval [CI], −12.2% to 9.0%). Noninferiority to Arm 1 was not confirmed for Arm 3 (difference, −3.5%; 95% CI, −13.6% to 6.6%) or Arm 4 (difference, −7.1%; 95% CI, −16.1% to 1.9%). Graft dysfunction (estimated glomerular filtration rate <40 mL/min/1.73 m2) was the main determinant of composite-endpoint efficacy failure across all arms. Conclusions In patients representative of the European kidney transplant population, tacrolimus QD-based immunosuppression (0.2 mg/kg/day), without induction, showed similar efficacy to 0.2 mg/kg per day tacrolimus BD

  18. Search for Bs -> mu+mu- and Bd -> mu+mu- Decays in ppbar Collisions with CDF II

    CERN Document Server

    Abulencia, A; Adelman, J; Affolder, T; Akimoto, T; Albrow, M G; Ambrose, D; Amerio, S; Amidei, D; Anastassov, A; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arguin, J F; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Azfar, F; Azzi-Bacchetta, P; Azzurri, P; Bacchetta, N; Bachacou, H; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Baroiant, S; Bartsch, V; Bauer, G; Bedeschi, F; Behari, S; Belforte, S; Bellettini, G; Bellinger, J; Belloni, A; Ben-Haim, E; Benjamin, D; Beretvas, A; Beringer, J; Berry, T; Bhatti, A A; Binkley, M; Bisello, D; Bishai, M; Blair, R E; Blocker, C; Bloom, K; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bölla, G; Bolshov, A; Bortoletto, D; Boudreau, J; Bourov, S; Boveia, A; Brau, B; Bromberg, C; Brubaker, E; Budagov, Yu A; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Byrum, K L; Cabrera, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carlsmith, D; Carosi, R; Carron, S; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chapman, J; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chou, J P; Chu, P H; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Ciljak, M; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Coca, M; Connolly, A; Convery, M E; Conway, J; Cooper, B; Copic, K; Cordelli, M; Cortiana, G; Cruz, A; Cuevas-Maestro, J; Culbertson, R; Cyr, D; Da Ronco, S; D'Auria, S; D'Onofrio, M; Dagenhart, D; De Barbaro, P; De Cecco, S; Deisher, A; De Lentdecker, G; Dell'Orso, Mauro; Demers, S; Demortier, L; Deng, J; Deninno, M; De Pedis, D; Derwent, P F; Dionisi, C; Dittmann, J; Di Turo, P; Dorr, C; Dominguez, A; Donati, S; Donega, M; Dong, P; Donini, J; Dorigo, T; Dube, S; Ebina, K; Efron, J; Ehlers, J; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, I; Fedorko, W T; Feild, R G; Feindt, M; Fernández, J P; Field, R; Flanagan, G; Flores-Castillo, L R; Foland, A; Forrester, S; Foster, G W; Franklin, M; Freeman, J C; Fujii, Y; Furic, I; Gajjar, A; Gallinaro, M; Galyardt, J; García, J E; Garcia Sciverez, M; Garfinkel, A F; Gay, C; Gerberich, H; Gerchtein, E; Gerdes, D; Giagu, S; Giannetti, P; Gibson, A; Gibson, K; Ginsburg, C; Giolo, K; Giordani, M; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D A; Gold, M; Goldschmidt, N; Goldstein, J; Gómez, G; Gómez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Gotra, Yu; Goulianos, K; Gresele, A; Griffiths, M; Grinstein, S; Grosso-Pilcher, C; Grundler, U; Guimarães da Costa, J; Haber, C; Hahn, S R; Hahn, K; Halkiadakis, E; Hamilton, A; Han, B Y; Handler, R; Happacher, F; Hara, K; Hare, M; Harper, S; Harr, R F; Harris, R M; Hatakeyama, K; Hauser, J; Hays, C; Hayward, H; Heijboer, A; Heinemann, B; Heinrich, J; Hennecke, M; Herndon, M; Heuser, J; Hidas, D; Hill, C S; Hirschbuehl, D; Höcker, A; Holloway, A; Hou, S; Houlden, M; Hsu, S C; Huffman, B T; Hughes, R E; Huston, J; Ikado, K; Incandela, J R; Introzzi, G; Iori, M; Ishizawa, Y; Ivanov, A; Iyutin, B; James, E; Jang, D; Jayatilaka, B; Jeans, D; Jensen, H; Jeon, E J; Jones, M; Joo, K K; Jun, S Y; Junk, T R; Kamon, T; Kang, J; Karagoz-Unel, M; Karchin, P E; Kato, Y; Kemp, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, M S; Kim, S B; Kim, S H; Kim, Y K; Kirby, M; Kirsch, L; Klimenko, S; Klute, M; Knuteson, B; Ko, B R; Kobayashi, H; Kondo, K; Kong, D J; Konigsberg, J; Kordas, K; Korytov, A; Kotwal, A V; Kovalev, A; Kraus, J; Kravchenko, I; Kreps, M; Kreymer, A; Kroll, J; Krumnack, N; Kruse, M; Krutelyov, V; Kuhlmann, S E; Kusakabe, Y; Kwang, S; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; Lecci, C; LeCompte, T; Lee, J; Lee, S W; Lefèvre, R; Leonardo, N; Leone, S; Levy, S; Lewis, J D; Li, K; Lin, C; Lin, C S; Lindgren, M; Lipeles, E; Liss, T M; Lister, A; Litvintsev, D O; Liu, T; Liu, Y; Lockyer, N S; Loginov, A; Loreti, M; Loverre, P F; Lu, R S; Lucchesi, D; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; Mack, P; MacQueen, D; Madrak, R; Maeshima, K; Maksimovic, P; Manca, G; Margaroli, F; Marginean, R; Marino, C; Martin, A; Martin, M; Martin, V; Martínez, M; Maruyama, T; Matsunaga, H; Mattson, M E; Mazini, R; Mazzanti, P; McFarland, K S; McGivern, D; McIntyre, P; McNamara, P; McNulty, R; Mehta, A; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Von der Mey, M; Miao, T; Miladinovic, N; Miles, J; Miller, R; Miller, J S; Mills, C; Milnik, M; Miquel, R; Miscetti, S; Mitselmakher, G; Miyamoto, A; Moggi, N; Mohr, B; Moore, R; Morello, M; Movilla-Fernández, P A; Mülmenstädt, J; Mukherjee, A; Mulhearn, M; Müller, T; Mumford, R; Murat, P; Nachtman, J; Nahn, S; Nakano, I; Napier, A; Naumov, D; Necula, V; Neu, C; Neubauer, M S; Nielsen, J; Nigmanov, T; Nodulman, L; Norniella, O; Ogawa, T; Oh, S H; Oh, Y D; Okusawa, T; Oldeman, R; Orava, R; Österberg, K; Pagliarone, C; Palencia, E; Paoletti, R; Papadimitriou, V; Papikonomou, A; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, Aldo L; Phillips, T J; Piacentino, G; Piedra, J; Pitts, K; Plager, C; Pondrom, L; Pope, G; Portell, X; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohos, F; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Rakitine, A; Rappoccio, S; Ratnikov, F; Reisert, B; Rekovic, V; Van Remortel, N; Renton, P B; Rescigno, M; Richter, S; Rimondi, F; Rinnert, K; Ristori, L; Robertson, W J; Robson, A; Rodrigo, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Rott, C; Ruiz, A; Russ, J; Rusu, V; Ryan, D; Saarikko, H; Sabik, S; Safonov, A; Sakumoto, W K; Salamanna, G; Salto, O; Saltzberg, D; Sánchez, C; Santi, L; Sarkar, S; Sato, K; Savard, P; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, E E; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, A L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Semeria, F; Sexton-Kennedy, L; Sfiligoi, I; Shapiro, M D; Shears, T G; Shepard, P F; Sherman, D; Shimojima, M; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sill, A; Sinervo, P; Sisakian, A; Sjölin, J; Skiba, A; Slaughter, A J; Sliwa, K; Smirnov, D; Smith, J R; Snider, F D; Snihur, R; Söderberg, M; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spinella, F; Squillacioti, P; Stanitzki, M; Staveris-Polykalas, A; Saint-Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Stuart, D; Suh, J S; Sukhanov, A; Sumorok, K; Sun, H; Suzuki, T; Taffard, A; Tafirout, R; Takashima, R; Takeuchi, Y; Takikawa, K; Tanaka, M; Tanaka, R; Tecchio, M; Teng, P K; Terashi, K; Tether, S; Thom, J; Thompson, A S; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tollefson, K; Tomura, T; Tonelli, D; Tonnesmann, M; Torre, S; Torretta, D; Tourneur, S; Trischuk, W; Tsuchiya, R; Tsuno, S; Turini, N; Ukegawa, F; Unverhau, T; Uozumi, S; Usynin, D; Vacavant, L; Vaiciulis, A W; Vallecorsa, S; Varganov, A; Vataga, E; Velev, G; Veramendi, G; Veszpremi, V; Vickey, T; Vidal, R; Vila, I; Vilar, R; Vollrath, I; Volobuev, I P; Würthwein, F; Wagner, P; Wagner, R G; Wagner, R L; Wagner, W; Wallny, R; Walter, T; Wan, Z; Wang, M J; Wang, S M; Warburton, A; Ward, B; Waschke, S; Waters, D; Watts, T; Weber, M; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Worm, S; Wright, T; Wu, X; Wynne, S M; Yagil, A; Yamamoto, K; Yamaoka, J; Yamashita, Y; Yang, C; Yang, U K; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zetti, F; Zhang, X; Zhou, J; Zucchelli, S

    2005-01-01

    We report on a search for Bs -> mu+mu- and Bd -> mu+mu- decays in ppbar collisions at sqrt(S) = 1.96 TeV using 364 pb-1 of data collected by the CDF II detector at the Fermilab Tevatron Collider. After applying all selection requirements, we observe no candidates inside the Bs or Bd mass windows, consistent with the background expectation. The resulting upper limits on the branching fractions are B(Bs -> mu+mu-) mu+mu-) < 3.9E-8 at 90% confidence level.

  19. Search for Bs --> mu+mu- and Bd --> mu+mu- Decays with 2fb-1 of ppbar Collisions

    CERN Document Server

    Aaltonen, T; Akimoto, T; Albrow, M G; Alvarez-Gonzalez, B; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Apresyan, A; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Aurisano, A; Azfar, F; Azzi-Bacchetta, P; Azzurri, P; Bacchetta, N; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Baroiant, S; Bartsch, V; Bauer, G; Beauchemin, P H; Bedeschi, F; Bednar, P; Behari, S; Bellettini, G; Bellinger, J; Belloni, A; Benjamin, D; Beretvas, A; Beringer, J; Berry, T; Bhatti, A; Binkley, M; Bisello, D; Bizjak, I; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bölla, G; Bolshov, A; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Bridgeman, A; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, Yu A; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Byrum, K L; Cabrerar, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carlsmith, D; Carosi, R; Carrillol, S; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavalli-Sforza, M; Cerri, A; Cerritop, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, K; Chokheli, D; Chou, J P; Choudalakis, G; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Compostella, G; Convery, M E; Conway, J; Cooper, B; Copic, K; Cordelli, M; Cortiana, G; Crescioli, F; Cuenca Almenarr, C; Cuevaso, J; Culbertson, R; Cully, J C; Dagenhart, D; Datta, M; Davies, T; De Barbaro, P; De Cecco, S; Deisher, A; De Lentdeckerd, G; De Lorenzo, G; Dell'Orso, Mauro; Demortier, L; Deng, J; Deninno, M; De Pedis, D; Derwent, P F; Di Giovanni, G P; Dionisi, C; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Donati, S; Dong, P; Donini, J; Dorigo, T; Dube, S; Efron, J; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, W T; Feild, R G; Feindt, M; Fernández, J P; Ferrazza, C; Field, R; Flanagan, G; Forrest, R; Forrester, S; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garberson, F; García, J E; Garfinkel, A F; Genser, K; Gerberich, H; Gerdes, D; Giagu, S; Giakoumopoloua, V; Giannetti, P; Gibson, K; Gimmell, J L; Ginsburg, C M; Giokarisa, N; Giordani, M; Giromini, P; Giunta, M; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Golossanov, A; Gómez, G; Gómez-Ceballos, G; Goncharov, M; Gonzlez, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Grinstein, S; Grosso-Pilcher, C; Group, R C; Grundler, U; Guimaraesda Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Hamilton, A; Han, B Y; Han, J Y; Handler, R; Happacher, F; Hara, K; Hare, D; Hare, M; Harper, S; Harr, R F; Harris, R M; Hartz, M; Hatakeyama, K; Hauser, J; Hays, C; Heck, M; Heijboer, A; Heinemann, B; Heinrich, J; Henderson, C; Herndon, M; Heuser, J; Hewamanage, S; Hidas, D; Hillc, C S; Hirschbuehl, D; Höcker, A; Hou, S; Houlden, M; Hsu, S C; Huffman, B T; Hughes, R E; Husemann, U; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ivanov, A; Iyutin, B; James, E; Jayatilaka, B; Jeans, D; Jeon, E J; Jindariani, S; Johnson, W; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Kar, D; Karchin, P E; Kato, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Klute, M; Knuteson, B; Ko, B R; Koay, S A; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kraus, J; Kreps, M; Kroll, J; Krumnack, N; Kruse, M; Krutelyov, V; Kubo, T; Kuhlmann, S E; Kuhr, T; Kulkarni, N P; Kusakabe, Y; Kwang, S; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; Le Compte, T; Lee, J; Lee, J; Lee, Y J; Leeq, S W; Lefèvre, R; Leonardo, N; Leone, S; Levy, S; Lewis, J D; Lin, C; Lin, C S; Linacre, J; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, T; Lockyer, N S; Loginov, A; Loreti, M; Lovas, L; Lu, R S; Lucchesi, D; Lueck, J; Luci, C; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; Mack, P; MacQueen, D; Madrak, R; Maeshima, K; Makhoul, K; Mäki, T; Maksimovic, P; Malde, S; Malik, S; Manca, G; Manousakisa, A; Margaroli, F; Marino, C; Marino, C P; Martin, A; Martin, M; Martinj, V; Martínez, M; Martinez-Ballarin, R; Maruyama, T; Mastrandrea, P; Masubuchi, T; Mattson, M E; Mazzanti, P; McFarland, K S; McIntyre, P; McNultyi, R; Mehta, A; Mehtälä, P; Menzemerk, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Miao, T; Miladinovic, N; Miles, J; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyake, H; Moed, S; Moggi, N; Moon, C S; Moore, R; Morello, M; Movilla-Fernández, P A; Mülmenstädt, J; Mukherjee, A; Müller, T; Mumford, R; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Nagano, A; Naganoma, J; Nakamura, K; Nakano, I; Napier, A; Necula, V; Neu, C; Neubauer, M S; Nielsenf, J; Nodulman, L; Norman, M; Norniella, O; Nurse, E; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Oldeman, R; Orava, R; Österberg, K; Pagan Griso, S; Pagliarone, C; Palencia, E; Papadimitriou, V; Papaikonomou, A; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, Aldo L; Phillips, T J; Piacentino, G; Piedra, J; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Portell, X; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohosh, F; Punzi, G; Pursley, J; Rademackerc, J; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Reisert, B; Rekovic, V; Renton, P B; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Roy, P; Ruiz, A; Russ, J; Rusu, V; Saarikko, H; Safonov, A; Sakumoto, W K; Salamanna, G; Salt, O; Santi, L; Sarkar, S; Sartori, L; Sato, K; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, E E; Schmidt, M A; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, A L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sfyria, A; Shalhout, S Z; Shapiro, M D; Shears, T G; Shepard, P F; Sherman, D; Shimojiman, M; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sinervo, P; Sisakian, A; Slaughter, A J; Slaunwhite, J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Söderberg, M; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spinella, F; Spreitzer, T; Squillacioti, P; Stanitzki, M; Saint-Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Stuart, D; Suh, J S; Sukhanov, A; Sun, H; Suslov, I; Suzuki, T; Taffarde, A; Takashima, R; Takeuchi, Y; Tanaka, R; Tecchio, M; Teng, P K; Terashi, K; Thomg, J; Thompson, A S; Thompson, G A; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Tourneur, S; Trischuk, W; Tu, Y; Turini, N; Ukegawa, F; Uozumi, S; Vallecorsa, S; Van Remortel, N; Varganov, A; Vataga, E; Vazquezl, F; Velev, G; Vellidisa, C; Veszpremi, V; Vidal, M; Vidal, R; Vila, I; Vilar, R; Vine, T; Vogel, M; Volobouevq, I; Volpi, G; Würthwein, F; Wagner, P; Wagner, R G; Wagner, R L; Wagner-Kuhr, J; Wagner, W; Wakisaka, T; Wallny, R; Wang, S M; Warburton, A; Waters, D; Weinberger, M; Wester, W C; Whitehouse, B; Whitesone, D; Wicklund, A B; Wicklund, E; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittichg, P; Wolbers, S; Wolfe, C; Wright, T; Wu, X; Wynne, S M; Yagil, A; Yamamoto, K; Yamaoka, J; Yamashita, T; Yang, C; Yangm, U K; Yang, Y C; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zhang, X; Zhengb, Y; Zucchelli, S

    2007-01-01

    We have performed a search for Bs-->mu+mu- and Bd-->mu+mu- decays in ppbar collisions at sqrt(s) = 1.96TeV using 2fb-1 of integrated luminosity collected by the CDF II detector at the Fermilab Tevatron Collider. The observed number of Bs and Bd candidates is consistent with background expectations. The resulting upper limits on the branching fractions are B(Bs-->mu+mu-) mu+mu-) < 1.8X10^-8 at 95% C.L.

  20. Charmless Hadronic Two-body Decays of $B_{u}$ and $B_{d}$ Mesons

    CERN Document Server

    Chen, Y H; Tseng, B; Yang, K C; Chen, Yaw-Hwang; Cheng, Hai-Yang; Yang, Kwei-Chou

    1999-01-01

    Two-body charmless nonleptonic decays of B_u and B_d mesons are studied within the framework of generalized factorization in which the effective Wilson coefficients $c^{eff}_i$ are renormalization-scale and -scheme independent while factorization is applied to the tree-level hadronic matrix elements. Contrary to previous studies, our $c_i^{eff}$ do not suffer from gauge and infrared problems. Nonfactorizable effects are parametrized in terms of N_c(LL) and N_c(LR), the effective numbers of colors arising from (V-A)(V-A) and (V-A)(V+A) four-quark operators, respectively. Tree and penguin transitions are classified into six different classes. The data of $B^-\\to\\rho^0\\pi^-$ and $B^-\\to\\phi K^-$ clearly indicate that $N_c(LR)\

  1. Mixing and CP-violation in the Bd and Bs systems at ATLAS

    CERN Document Server

    Wharton, Andrew Mark; The ATLAS collaboration

    2016-01-01

    Search for deviations from the standard model is performed in the systems of the neutral B mesons. The Bs system is studied in the decay into J/psi phi. The mixing phase phi_s and the width difference DeltaGamma_s are determined through the simultaneous study of angular distributions in the final state and of the decay time, performed together with flavour tagging at production. The measurement performed by ATLAS with the full LHC Run-1 sample is discussed and compared to the previous world average. The width difference DeltaGamma_d in the Bd system is obtained from the comparison of the decay time distributions in the flavour specific state J/psi K* and in the CP eigenstate J/psi KS. The result obtained from the full sample of data collected by ATLAS at 7 and 8 TeV is the most accurate single measurement of the width difference currently available.

  2. Near-Earth Asteroids 2006 RH120 AND 2009 BD: Proxies for Maximally Accessible Objects?

    Science.gov (United States)

    Barbee, Brent W.; Chodas, Paul W.

    2015-01-01

    NASA's Near-Earth Object Human Space Flight Accessible Targets Study (NHATS) has identified over 1,400 of the approximately 12,800 currently known near-Earth asteroids (NEAs) as more astrodynamically accessible, round-trip, than Mars. Hundreds of those approximately 1,400 NEAs can be visited round-trip for less change-in-velocity than the lunar surface, and dozens can be visited round-trip for less change-in-velocity than low lunar orbit. How accessible might the millions of undiscovered NEAs be? We probe that question by investigating the hypothesis that NEAs 2006 RH120 and 2009 BD are proxies for the most accessible NEAs we would expect to find, and describing possible future NEA population model studies.

  3. PHOTOIONIZATION MODELS OF THE INNER GASEOUS DISK OF THE HERBIG BE STAR BD+65 1637

    Energy Technology Data Exchange (ETDEWEB)

    Patel, P.; Sigut, T. A. A.; Landstreet, J. D., E-mail: ppatel54@uwo.ca [Department of Physics and Astronomy, The University of Western Ontario, London, Ontario Canada N6A 3K7 (Canada)

    2016-01-20

    We attempt to constrain the physical properties of the inner, gaseous disk of the Herbig Be star BD+65 1637 using non-LTE, circumstellar disk codes and observed spectra (3700–10500 Å) from the ESPaDOnS instrument on the Canada–France–Hawaii Telescope. The photoionizing radiation of the central star is assumed to be the sole source of input energy for the disk. We model optical and near-infrared emission lines that are thought to form in this region using standard techniques that have been successful in modeling the spectra of classical Be stars. By comparing synthetic line profiles of hydrogen, helium, iron, and calcium with the observed line profiles, we try to constrain the geometry, density structure, and kinematics of the gaseous disk. Reasonable matches have been found for all line profiles individually; however, no disk density model based on a single power law for the equatorial density was able to simultaneously fit all of the observed emission lines. Among the emission lines, the metal lines, especially the Ca ii IR triplet, seem to require higher disk densities than the other lines. Excluding the Ca ii lines, a model in which the equatorial disk density falls as 10{sup −10} (R{sub *}/R){sup 3} g cm{sup −3} seen at an inclination of 45° for a 50 R{sub *} disk provides reasonable matches to the overall line shapes and strengths. The Ca ii lines seem to require a shallower drop-off as 10{sup −10} (R{sub *}/R){sup 2} g cm{sup −3} to match their strength. More complex disk density models are likely required to refine the match to the BD+65 1637 spectrum.

  4. The Design of the Vehicle Terminal System for Navigation Based on BD2/GPS Dual-mode%BD2/GPS双模车载导航终端系统设计

    Institute of Scientific and Technical Information of China (English)

    王华; 蒋玉东

    2013-01-01

    As a satellite navigation system that has independently developed and testablished by china, the use of the BDS wil fundamental y solve the problem of facing the risk of long-term dependence on GPS system. However, before the technology is not ful y mature, the dual-mode navigation based BD2/GPS wil be the development trend of the vehicle navigation. This paper presents a design program of the vehicle terminal system for navigation based on BD2/GPS dual-mode, including hardware and software systems, and describes the design ideas.%  作为中国自主研制和建立的卫星导航系统,BDS的运行将从根本上解决长期依赖于GPS系统面临的风险问题。但在技术没完全成熟之前, BD2/GPS双模导航将是车载导航的发展趋势。文章提出了一种基于BD2/GPS的双模车载导航终端系统的设计方案,包括硬件系统和软件系统,并介绍了设计思路。

  5. Expression of beta-defensins pBD-1 and pBD-2 along the small tract of the pig: Lack of upregulation in vivo upon Salmonella typhimurium infection

    NARCIS (Netherlands)

    Veldhuizen, E.J.; Dijk, van A.; Tersteeg, M.H.; Kalkhove, S.I.; Meulen, van der J.; Niewold, T.A.; Haagsman, H.P.

    2007-01-01

    Defensins are antimicrobial peptides that play an important role in the innate immune response in the intestine. Up to date, only one ß-defensin (pBD-1), has been described in pig, which was found to be expressed at low levels in the intestine. We set-up a quantitative PCR method to detect the gene

  6. BD FACSAriaIII流式细胞仪在血液学中的使用分析研究%Application of BD FACSAriaIII flow cytometer in the research

    Institute of Scientific and Technical Information of China (English)

    梁昊岳; 程雪莲; 杨晚竹; 王金宏

    2014-01-01

    目的:对BD FACSAriaIII流式细胞仪在应用中出现的故障原因进行分析、研究,为在科研工作中正确使用该仪器提供依据。方法:通过对2012-2013年实验血液学国家重点实验室技术平台BD FACSAriaIII流式细胞仪的使用情况进行统计,对使用过程中出现的常见故障和需要由厂商工程师现场解决的故障进行统计,总结出高发故障的原因及解决方法。结果:通过对BD FACSAriaIII流式细胞仪的故障进行分析,为高通量流式细胞分选仪的正确使用提供指导,提高仪器运行的稳定性。结论:正确的使用和良好的维护有助于保证BD FACSAriaIII流式细胞仪的正常运行,从而确保科研工作的顺利进行。%Objective:To provide a basis for proper use of BD FACSAriaIII flow cytometer by analyzing the related causes of its malfunction.Methods: Through study of using BD FACSAriaIII flow cytometer in core facilities of State Key Laboratory of Experimental Hematology in 2012-2013, frequently occurred malfunction, solved malfunction by manufacturer’s engineers and their causes and solutions are summarized.Results: To provide guidance of using high throughput cell sorters and improve the stability of running the instrument.Conclusion: Proper use and good repair helps to guarantee the normal operation of BD FACSAriaIII flow cytometer.

  7. Working Effectively with Students with BD in a General Education Classroom: The Case for Universal Design for Learning

    Science.gov (United States)

    Johnson-Harris, Kimberly M.; Mundschenk, Nancy A.

    2014-01-01

    To one degree or another, inclusion is the word of the day in public schools across the country, and as a result many general education teachers find themselves face-to-face in their classrooms with students who have been diagnosed with behavior disorders (BD). While the behavior of these students is frequently (and euphemistically) referred to as…

  8. Comparative Evaluation of Inoculation of Urine Samples with the Copan WASP® and BD Kiestra™ InoqulA™ Instruments

    DEFF Research Database (Denmark)

    Iversen, Jesper; Stendal, Gitta; Gerdes, Cecilie Marie;

    2016-01-01

    This study evaluated quantitative results as well as the quality of the inoculation patterns on urine specimens produced by two automated instruments, the Copan WASP® and the BD InoqulA™. 526 urine samples submitted in 10 ml canisters containing boric acid were processed within 30 minutes...

  9. Tolerance and antiviral effects of high-dose interferon-alpha B/D in patients with chronic hepatitis B

    NARCIS (Netherlands)

    Rasch, MC; Schellekens, H; van Dijck, CMM; Haagsma, EB; Michielsen, PP; van Buuren, AHJAM; Stotter, H; van Hattum, J

    1998-01-01

    A novel recombinant interferon-alpha B/D hybrid was applied to assess tolerability, antiviral effect, and biological activity in chronic hepatitis B. The study was designed as an open nonrandomized trial. Treatment comprised a two-week run-in phase with 16 MU three times a week followed by 14 weeks

  10. The cytochrome bd-I respiratory oxidase augments survival of multidrug-resistant Escherichia coli during infection

    Science.gov (United States)

    Shepherd, Mark; Achard, Maud E. S.; Idris, Adi; Totsika, Makrina; Phan, Minh-Duy; Peters, Kate M.; Sarkar, Sohinee; Ribeiro, Cláudia A.; Holyoake, Louise V.; Ladakis, Dimitrios; Ulett, Glen C.; Sweet, Matthew J.; Poole, Robert K.; McEwan, Alastair G.; Schembri, Mark A.

    2016-01-01

    Nitric oxide (NO) is a toxic free radical produced by neutrophils and macrophages in response to infection. Uropathogenic Escherichia coli (UPEC) induces a variety of defence mechanisms in response to NO, including direct NO detoxification (Hmp, NorVW, NrfA), iron-sulphur cluster repair (YtfE), and the expression of the NO-tolerant cytochrome bd-I respiratory oxidase (CydAB). The current study quantifies the relative contribution of these systems to UPEC growth and survival during infection. Loss of the flavohemoglobin Hmp and cytochrome bd-I elicit the greatest sensitivity to NO-mediated growth inhibition, whereas all but the periplasmic nitrite reductase NrfA provide protection against neutrophil killing and promote survival within activated macrophages. Intriguingly, the cytochrome bd-I respiratory oxidase was the only system that augmented UPEC survival in a mouse model after 2 days, suggesting that maintaining aerobic respiration under conditions of nitrosative stress is a key factor for host colonisation. These findings suggest that while UPEC have acquired a host of specialized mechanisms to evade nitrosative stresses, the cytochrome bd-I respiratory oxidase is the main contributor to NO tolerance and host colonisation under microaerobic conditions. This respiratory complex is therefore of major importance for the accumulation of high bacterial loads during infection of the urinary tract. PMID:27767067

  11. New Possibility of Solving the Problem of Lifetime Ratio $\\tau (\\Lambda_b) / \\tau (B_d)$

    CERN Document Server

    Ito, T; Matsui, Y; Ito, Toshiaki; Matsuda, Masahisa; Matsui, Yoshimitsu

    1998-01-01

    We discuss the problem of the large discrepancy between the observed lifetime ratio of $B_d$ to $\\Lambda_b$ and the theoretical prediction obtained by the heavy quark effective theory. A new possibility of solving this problem is proposed from the viewpoint of operator product expansion and the lifetime ratio of $\\Lambda_b$ to $\\Omega_b$ is predicted.

  12. Sodium cromoglycate inhibits absorption of the major soybean allergen, Gly m Bd 30K, in mice and human intestinal Caco-2 cells.

    Science.gov (United States)

    Weangsripanaval, Thanakorn; Murota, Kaeko; Murakami, Yoko; Kominami, Masaru; Kusudo, Tatsuya; Moriyama, Tatsuya; Ogawa, Tadashi; Kawada, Teruo

    2006-11-01

    Our previous data showed that Gly m Bd 30K was absorbed from the gastrointestinal tract and circulated in blood in mice. This study was conducted to determine the mechanism and identify the inhibitor of such absorption. Using sandwich ELISA and immunoblotting, we found that intact Gly m Bd 30K was absorbed from apical to basolateral solutions and intracellularly accumulated by Caco-2 cells in a dose- and time-dependent manner. The absorption and intracellular accumulation of Gly m Bd 30K were significantly suppressed when Caco-2 cells were treated with sodium cromoglycate (SCG) (0-50 mmol/L) in a dose-dependent manner. In 24-d-old mice orally treated with SCG (10-1000 mg/kg body weight), plasma Gly m Bd 30K concentration decreased significantly 30-120 min after Gly m Bd 30K (2000 mg/kg body weight) administration. Moreover, inhibitors that suppress the clathrin-dependent endocytosis dansylcadaverine, the caveolae-dependent endocytosis nystatin and clathrin, and the caveolae-dependent endocytosis methyl-beta-cyclodextrin had inhibitory effects on the absorption and intracellular accumulation of Gly m Bd 30K by Caco-2 cells. These data indicate that Gly m Bd 30K is absorbed and intracellularly accumulated in Caco-2 cells via clathrin- or caveolae-dependent endocytosis. We propose that the absorption and intracellular accumulation of Gly m Bd 30K are inhibited by SCG via clathrin- or caveolae-dependent endocytosis.

  13. A Member of the 14-3-3 Gene Family in Brachypodium distachyon, BdGF14d, Confers Salt Tolerance in Transgenic Tobacco Plants

    Science.gov (United States)

    He, Yuan; Zhang, Yang; Chen, Lihong; Wu, Chunlai; Luo, Qingchen; Zhang, Fan; Wei, Qiuhui; Li, Kexiu; Chang, Junli; Yang, Guangxiao; He, Guangyuan

    2017-01-01

    Plant 14-3-3 proteins are involved in diverse biological processes, but for the model monocotyledonous species, Brachypodium distachyon, their roles in abiotic stress tolerance are not well understood. In this study, a total of eight Bd14-3-3 genes were identified from B. distachyon and these were designated respectively as BdGF14a–BdGF14g. The qRT-PCR analyses of 3-month-old plants of B. distachyon showed that these genes were all expressed in the stems, leaves, and spikelets. By contrast, most of the plants had relatively lower transcriptional levels in their roots, except for the BdGF14g gene. The different expression profiles of the Bd14-3-3s under various stress treatments, and the diverse interaction patterns between Bd14-3-3s and BdAREB/ABFs, suggested that these gene products probably had a range of functions in the stress responses. The NaCl-induced Bd14-3-3 gene, BdGF14d, was selected for overexpression in tobacco. BdGF14d was found to be localized throughout the cell and it conferred enhanced tolerance to salt in the transgenic plants. Lowered contents of malondialdehyde, H2O2, and Na+, and lower relative electronic conductance (Rec%), yet greater activities of catalase and peroxidase, were observed in the overexpressing plants. Higher photosynthetic rate, transpiration rate, stomatal conductance, and water use efficiency were measured in the transgenic lines. Following abscisic acid (ABA) or NaCl treatment, stomatal aperture in leaves of the BdGF14d-overexpression plants was significantly lower than in leaves of the wild type (WT) controls. The stress-related marker genes involved in the ABA signaling pathway, the reactive oxygen species (ROS)-scavenging system, and the ion transporters were all up-regulated in the BdGF14d-overexpressing plants as compared with WT. Taken together, these results demonstrate that the Bd14-3-3 genes play important roles in abiotic stress tolerance. The ABA signaling pathway, the ROS-scavenging system, and ion

  14. The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking.

    Science.gov (United States)

    Sabino, Valentina; Cottone, Pietro; Zhao, Yu; Iyer, Malliga R; Steardo, Luca; Steardo, Luca; Rice, Kenner C; Conti, Bruno; Koob, George F; Zorrilla, Eric P

    2009-05-01

    Sigma-Receptors (SigRs) have been implicated in behavioral and appetitive effects of psychostimulants and may also modulate the motivating properties of ethanol. This study tested the hypothesis that SigRs modulate ethanol reinforcement and contribute to excessive ethanol intake. The effects of subcutaneous treatment with the potent, selective Sig-1R antagonist BD-1063 on operant ethanol self-administration were studied in two models of excessive drinking-Sardinian alcohol-preferring (sP) rats and acutely withdrawn ethanol-dependent Wistar rats-and compared to ethanol self-administration in nondependent Wistar controls. To assess the specificity of action, the effects of BD-1063 on self-administration of an equally reinforcing saccharin solution were determined in Wistar and sP rats. Gene expression of Sig-1R in reward-related brain areas implicated in ethanol reinforcement was compared between ethanol-naive sP and Wistar rats and withdrawn ethanol-dependent Wistar rats. BD-1063 dose dependently reduced ethanol self-administration in sP rats (3.3-11 mg/kg) and withdrawn, dependent Wistar rats (4-11 mg/kg) at doses that did not modify mean ethanol self-administration in nondependent Wistar controls. BD-1063 did not reduce concurrent water self-administration and did not comparably suppress saccharin self-administration, suggesting selectivity of action. BD-1063 also reduced the breakpoints of sP rats to work for ethanol under a progressive-ratio reinforcement schedule. Ethanol-naive sP rats and 24-h withdrawn, dependent Wistar rats showed reduced Sig-1R mRNA expression in the nucleus accumbens. The results suggest that SigR systems may contribute to innate or ethanol-induced increases in susceptibility to self-administer high ethanol levels, identifying a potential neuroadaptive mechanism contributing to excessive drinking and a therapeutic target for alcohol abuse and dependence.

  15. Detection of Phosphorus, Sulphur, and Zinc in the Carbon-enhanced Metal-poor Star BD+44 493

    Science.gov (United States)

    Roederer, Ian U.; Placco, Vinicius M.; Beers, Timothy C.

    2016-06-01

    The carbon-enhanced metal-poor star BD+44°493 ([Fe/H] = -3.9) has been proposed as a candidate second-generation star enriched by metals from a single Pop III star. We report the first detections of P and S and the second detection of Zn in any extremely metal-poor carbon-enhanced star, using new spectra of BD+44°493 collected by the Cosmic Origins Spectrograph on the Hubble Space Telescope. We derive [P/Fe] = -0.34 ± 0.21, [S/Fe] = +0.07 ± 0.41, and [Zn/Fe] = -0.10 ± 0.24. We increase by 10-fold the number of Si i lines detected in BD+44°493, yielding [Si/Fe] = +0.15 ± 0.22. The [S/Fe] and [Zn/Fe] ratios exclude the hypothesis that the abundance pattern in BD+44°493 results from depletion of refractory elements onto dust grains. Comparison with zero-metallicity supernova (SN) models suggests that the stellar progenitor that enriched BD+44°493 was massive and ejected much less than 0.07 M ⊙ of 56Ni, characteristic of a faint SN. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute (STScI), which is operated by the Association of Universities for Research in Astronomy, Inc. (AURA) under NASA contract NAS 5-26555. These observations are associated with program GO-14231.

  16. Constructed a cell line to express hBD1 stablly and detected the antimicrobial activity of hBD1 to multidrug resistant bacterial strains%hBD1稳定表达细胞株的建立及其表达产物对多重耐药菌的活性检测

    Institute of Scientific and Technical Information of China (English)

    崔南; 陈新年; 魏莲花; 李娟; 邹凤梅

    2011-01-01

    目的 构建人β防御素1( hBD1)稳定表达细胞株并检测其对多种多重耐药菌的抗菌活性.方法 将重组质粒pCMV-hBD1通过阳离子脂质体转染于非洲绿猴SV40转化的肾细胞(COS-7细胞),经过G418压力筛选后获得单克隆细胞株;提取细胞总RNA,用RT-PCR检测目的基因在转录水平的表达;收集细胞培养上清液,用Western blot检测hBD1基因蛋白的表达;将含有表达产物hBD1的细胞培养上清液分别同各耐药菌液混合,37℃孵育不同时间后涂布于LB平板,以各实验组和对照组的菌落数的比值作为该耐药菌的存活率.结果 经过G418压力筛选所得到的稳定表达细胞株,在转录水平和蛋白水平均检测到目的基因hBD1的表达,在表达产物hBD1的作用下,多重耐药鲍氏不动杆菌、多重耐药大肠埃希菌存活率和多重耐药肺炎克雷伯杆菌的存活率可以分别降至9%、22%和50%,多重耐药嗜麦芽窄食单胞菌的存活率同对照组没有明显差异.结论 成功获得hBD1稳定表达细胞株,目的基因hBD1的表达产物对多种多重耐药菌均具有抗菌活性.%Objective To established a cell line that expresses hBD1 stably,and detected the antimicrobial activity of the hBD1 to the muhidrug resistant bacterial strains.Methods Recombinant plasmid was introduced into COS-7 cells by lipofectamine,cells were selected in culture medium containing G418 to acquired the monoclonal cell lines,total RNA were extracted from the cultured cells,expression levels of hBD1 mRNA was identified by RT-PCR,collected the supernatant solution of the cultured cell,expression levels of protein was identified by Western blot.Put the expression products and resistant organisms mixed together,after incubation in different times in 37℃,coating the mixtures in LB flat,then obtained the ratios between colonies number of experimental groups and colonies number of control groups,put those ratios as the survival rate of the drug

  17. Research of smoothing pseudo-range algorithm by Doppler based on GPS/BD

    Science.gov (United States)

    Kang, Chuanli; Zhou, Yanliu

    2015-12-01

    GNSS (Global Navigation Satellite System) technology not only in the general field of surveying and mapping, geology, mining, water and electricity, and in particular in the field of public security, fire protection, tourism, search and rescue, adventure have been more widely used. These special areas require real-time and high positioning accuracy. Currently, GNSS precision positioning technology has become a hot research direction. This paper introduced an algorithm of smoothing pseudo range by Doppler based GPS/BD to improve GNSS positioning precision. This algorithm decoded the pseudo range data and ephemeris data, and then designed algorithm of smoothing pseudo range by Doppler according principle of Doppler smoothing pseudo range. This algorithm was realized by C++ and proved its efficiency. At last, this algorithm has proved its correctness through calculating and analyzing practical Doppler and pseudo range data, and then a conclusion has been obtained: the Doppler value precision is sub-meter, far better than the pseudo-range accuracy, so that if the two data are combined to calculate position that can help to improve the positioning accuracy.

  18. Longevity Tests of High-Sensitivity BD-PND Bubble Dosimeters

    Energy Technology Data Exchange (ETDEWEB)

    Radev, R; Carlberg, E

    2002-07-09

    Medium- and very-high-sensitivity neutron bubble dosimeters (BD-PNDs) made by Bubble Technology Industries (BTI) were used to study the life span of such dosimeters in a standard setup with a {sup 252}Cf source. Although data on the longevity of bubble dosimeters with low and medium sensitivity exist, such data for dosimeters with high and very high sensitivity are not readily available. The manufacturer guarantees optimum dosimeter performance for 3 months after receipt. However, it is important to know the change in the dosimeters' characteristics with time, especially after the first 3 months. The long-term performance of four sets of very high sensitivity and one set of medium-sensitivity bubble dosimeters was examined for periods of up to 13 months. During that time, the detectors were exposed and reset more than 20 times. Although departures from initial detection sensitivity were observed in several cases, the detectors indicated a significantly longer life span than stated in the manufacturer's warranty. In addition, the change in the number of bubbles and in evaluated neutron dose as a function of the time from the end of exposure until the dosimeters were read was investigated.

  19. Modified electrochemical parameter estimation of NCR18650BD battery using implicit finite volume method

    Science.gov (United States)

    Ashwin, T. R.; McGordon, A.; Widanage, W. D.; Jennings, P. A.

    2017-02-01

    The Pseudo Two Dimensional (P2D) porous electrode model is less preferred for real time calculations due to the high computational expense and complexity in obtaining the wide range of electro-chemical parameters despite of its superior accuracy. This paper presents a finite volume based method for re-parametrising the P2D model for any cell chemistry with uncertainty in determining precise electrochemical parameters. The re-parametrisation is achieved by solving a quadratic form of the Butler-Volmer equation and modifying the anode open circuit voltage based on experimental values. Thus the only experimental result, needed to re-parametrise the cell, reduces to the measurement of discharge voltage for any C-rate. The proposed method is validated against the 1C discharge data and an actual drive cycle of a NCR18650BD battery with NCA chemistry when driving in an urban environment with frequent accelerations and regenerative braking events. The error limit of the present model is compared with the electro-chemical prediction of LiyCoO2 battery and found to be superior to the accuracy of the model presented in the literature.

  20. Molecular detection of common intestinal parasites: a performance evaluation of the BD Max™ Enteric Parasite Panel.

    Science.gov (United States)

    Batra, R; Judd, E; Eling, J; Newsholme, W; Goldenberg, S D

    2016-11-01

    The purpose of this study was to evaluate the level of agreement of the BD Max™ Enteric Parasite Panel (EPP) with microscopy for the detection of Giardia duodenalis, Cryptosporidium spp. and Entamoeba histolytica in stool samples. A total of 372 stool samples (partly collected on the basis of positive microscopy and partly unselected, consecutive sample submitted for parasite investigation) were tested with EPP according to manufacturer's instructions and also using microscopy according to standard techniques. Discrepant samples were further tested using PCR by the National Parasitology reference laboratory. Levels of agreement and laboratory turnaround times were measured and compared. Overall, positive and negative percent agreement was high between the two methods. However, microscopy resulted in four false positives and one false negative for G. duodenalis and two false positives for Cryptosporidium. Additionally, microscopy could not differentiate between E. histolytica and Entamoeba dispar. Median laboratory turnaround time was 65 hours for microscopy; results from EPP could be available after four hours. Blastocycstis hominis was detected by microscopy in one sample and would have been missed if only EPP was performed. The EPP was a good alternative to microscopy, detecting a small number of additional positives that were missed by microscopy. The assay is significantly faster than microscopy and allows laboratory workflows to be streamlined. The risk of missing parasites that are not included in the EPP appears to be minimal in the studied population; however, there may be certain patient groups who would benefit from microscopic examination of stools.

  1. Agrowaste to vanillin conversion by a natural Pediococcus acidilactici strain BD16.

    Science.gov (United States)

    Chakraborty, Debkumar; Kaur, Baljinder; Obulisamy, Karthikeyan; Selvam, Ammaiyappan; Wong, Jonathan W C

    2016-10-13

    Owing to its flavoring, antimicrobial, antioxidant and anticarcinogenic nature, vanillin is widely used in foods, beverages, perfumes and pharmaceutical products. Ferulic acid (FA) is an important precursor of vanillin which is abundant in cereals like maize, rice and wheat and sugar beet. A major drawback of microbial vanillin production from FA is the degradation and biotransformation of toxic vanillin to other phenolic derivatives. The present study is undertaken to explore microbial vanillin production from FA precursor rice bran by employing vanillin-resistant Pediococcus acidilactici BD16, a natural lactic acid bacteria isolate. Extracellular, intracellular and cellular vanillin dehydrogenase activity was found least, which was minimized vanillin degradation, and the strain resists more than 5 g L(-1) vanillin in the medium. A metabolomics approach was followed for the detection of FA, vanillin and other metabolites generated during fermentation of rice bran medium. A metabolic pathway was also predicted for vanillin biosynthesis. Approximately 1.06 g L(-1) of crude vanillin was recovered from rice-bran-containing medium and this further offers scope for the industrial utilization of the organism and its genetic manipulation to enhance production of biovanillin.

  2. The Angular Expansion and Distance of the Planetary Nebula BD+30 3639

    CERN Document Server

    Li, J; Borkowski, K J; Li, Jianyang; Borkowski, Kazimierz J.

    2002-01-01

    The WFPC2 camera aboard the HST was used to obtain images of the planetary nebula BD+30 3639 at two epochs separated by 5.663 years. The expansion of the nebula in the H-alpha and [N II] bands has been measured using several methods. Detailed expansion maps for both emission lines were constructed from nearly 200 almost independent features. There is good agreement between the (independent) H-alpha and [N II] proper motions. The central velocity split is measured from the STIS echelle spectra of the C II] 2326A multiplet to be +/-36.3 km/s at a position angle of 99 degrees. The angular displacement along this slit position was measured to be 4.25 mas/yr at 2".47 from the center. We constructed a tilted ellipsoidal shell model by fitting the radio brightness variation of the 5 and 15 GHz VLA observations, and making use of the ground-based echelle spectra from Bryce & Mellema (1999), to estimate distance. Our model has an axial ratio of 1.56, is inclined to the line of sight by 9.7 degrees, and exhibits an...

  3. Albertet, “En amor trob tantz de mals seignoratges” (BdT 16.13

    Directory of Open Access Journals (Sweden)

    Francesca Sanguineti

    2008-12-01

    Full Text Available The article provides a commentary and a new critical edition of Albertet’s poem “En amor trob tantz de mals seignoratges”, in which the troubadour praises some of the most courtly ladies of his time. The poem can be linked to the genre of the collective eulogy, where the enumerated ladies are praised essentially for political reasons, since the commendation is clearly addressed to the men hidden behind them: famous specimena of this genre are the ‘tournoiements des dames’ by Huon d’Oisy and Richard de Semilli and Raimbaut de Vaqueiras’ “Carros” (BdT 392.32. Albertet’s song starts with a misogynic tone, since the poet declares that celebrating or loving ladies is worthless, given their immoral behaviour, and with a polemic against the strict rules of courtly love. This misogyny, as is further discovered, is a rhetorical device to praise women as well as a tool to renew the genre of the love song from a thematic point of view.

  4. Expressão cutânea das β-defensinas (cBD102 e cBD103) em cães acometidos por leishmaniose visceral

    OpenAIRE

    Hernandez, Fernely Augusto Plazas

    2012-01-01

    Em resposta a uma infeção as defensinas são produzidas em questão de minutos ou até 2 horas por células sanguíneas como neutrófilos, para auxiliar a lise de patógenos e estimular a quimiotaxia, alcançando níveis máximos no organismo em 24 horas. Também estes peptídeos podem ser produzidos sem estimulo algum pelas células epiteliais do sistema tegumentário. Com base no exposto anteriormente, o objetivo deste trabalho foi estudar a expressão de β-defensinas (cBD102 e cBD103) de pele de cãe...

  5. Performance of Combined GPS/BD Positioning%GPS/BD组合导航定位试验和精度分析

    Institute of Scientific and Technical Information of China (English)

    刘季; 张小红

    2012-01-01

    We discussed some main issues of combined GPS/BD single point positioning. A pro- gram was developed to process the combined GPS/BD data. Availability and positioning accuracy of BD and combined GPS/BD were analyzed. Preliminary results show that BD can provide re- gional navigation and positioning service with a accuracy of around 15 meters. Combined GP, S and BD cannot improve positioning accuracy under the condition that enough visible GPS satellites are available. In the case of bad GPS satellites geometry with insufficient visible GPS satellites, com- bined GPS/BD can improve positioning stability and accuracy.%讨论了GPS/BD组合定位需要考虑的主要问题,自编了GPS/BD组合定位程序,利用实测GPS/BD观测数据分析了当前北斗导航定位系统可用性及GPS/BD组合前后的定位精度。试验结果表明,北斗已经能够提供区域的实时导航定位服务。GPS/BD组合定位在GPS观测卫星数较多时对GPS定位精度改善不明显,在GPS观测卫星数较少时可以显著提高定位精度和稳定性。

  6. X-ray Observations of Bow Shocks around Runaway O Stars. The case of $\\zeta$ Oph and BD+433654

    CERN Document Server

    Toalá, J A; González-Gaán, A; Guerrero, M A; Ignace, R; Pohl, M

    2016-01-01

    Non-thermal radiation has been predicted within bow shocks around runaway stars by recent theoretical works. We present X-ray observations towards the runaway stars $\\zeta$ Oph (Chandra and Suzaku) and BD+433654 (XMM-Newton) to search for the presence of non-thermal X-ray emission. We found no evidence of non-thermal emission spatially coincident with the bow shocks, nonetheless, diffuse emission is detected in the vicinity of $\\zeta$ Oph. After a careful analysis of its spectral characteristics we conclude that this emission has a thermal nature with a plasma temperature of $T \\approx 2 \\times10^{6}$ K. The cometary shape of this emission seems to be in line with recent predictions of radiation-hydrodynamic models of runaway stars. The case of BD+433654 is puzzling as non-thermal emission has been reported in a previous work for this source.

  7. Raimbaut de Vaqueiras, “[Oi] altas undas que venez suz la mar” (BdT 392.5a

    Directory of Open Access Journals (Sweden)

    Saverio Guida

    2013-06-01

    Full Text Available The aim of the present paper is to return to the discussion on the authorship of BdT 392.5 and argue for attributing the poem to Raimbaut de Vaqueiras. I believe that the affinities in theme, situation and expression between “[Oi] altas undas que venez suz la mar” and the song “Belh Monruelh” (BdT 70.11, that I tried to link to Raimbaut in a previous study, should not be overlooked. An important clue is that the wind motif, present in the latter song, also occurs several times in the Occitan troubadour’s production, to the extent that it would seem a tried and tested semiotic marker. Neither should the underlying narrative quality of the text in search of an author be ignored, nor the popular tone that characterizes it, which are both compatible with attitudes expressed by the “fill d’un paubre cavaillier de Proensa”, who frequently makes use of popular song and does not shun the adoption and elevation in a classless manner of features of more ‘humble’ origin. Moreover, of utmost importance is the use in l. 10 of BdT 392.5a of the verb-form “aportai”, an imperative form (confirmed by the rhyme found in northern Italy (and in particular in the Liguria-Piedmont area, where Raimbaut spent many years and which is employed, as a clear dialect feature, significantly in l. 27 of the ‘tenso’ between the Occitan troubadour and the Genoese lady (BdT 392.7.

  8. High level expression of human epithelial β-defensins (hBD-1, 2 and 3 in papillomavirus induced lesions

    Directory of Open Access Journals (Sweden)

    Chong Kong T

    2006-09-01

    Full Text Available Abstract Background Epithelial defensins including human β-defensins (hBDs and α-defensins (HDs are antimicrobial peptides that play important roles in the mucosal defense system. However, the role of defensins in papillomavirus induced epithelial lesions is unknown. Results Papilloma tissues were prospectively collected from 15 patients with recurrent respiratory papillomatosis (RRP and analyzed for defensins and chemokine IL-8 expression by quantitative, reverse-transcriptase polymerase chain reaction (RT-PCR assays. HBD-1, -2 and -3 mRNAs were detectable in papilloma samples from all RRP patients and the levels were higher than in normal oral mucosal tissues from healthy individuals. Immunohistochemical analysis showed that both hBD-1 and 2 were localized in the upper epithelial layers of papilloma tissues. Expression of hBD-2 and hBD-3 appeared to be correlated as indicated by scatter plot analysis (r = 0.837, p Conclusion Human β-defensins are upregulated in respiratory papillomas. This novel finding suggests that hBDs might contribute to innate and adaptive immune responses targeted against papillomavirus-induced epithelial lesions.

  9. Lack of effects of GHB precursors GBL and 1,4-BD following i.c.v. administration in rats.

    Science.gov (United States)

    Carter, Lawrence P; Koek, Wouter; France, Charles P

    2006-11-01

    Gamma-hydroxybutyrate (GHB) is used therapeutically and recreationally worldwide. Since the scheduling of GHB by the USA and the United Nations in 2000-2001, the recreational use of GHB precursors has reportedly increased. The aim of this study was to examine if potency differences of GHB and GHB-like compounds are due to their blood-brain barrier permeability. The effects of peripheral and central administration of GHB, GHB precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD), and the gamma-aminobutyric acid (GABA)(B) receptor agonist baclofen on schedule-controlled responding were examined in rats. GHB and baclofen were 276- and 253-fold more potent, respectively, after intracerebroventricular (i.c.v.) administration than after intraperitoneal (i.p.) administration, whereas GBL and 1,4-BD, up to a dose of 1780 microg were without effect after i.c.v. administration. These data suggest that GBL and 1,4-BD are not metabolically converted to GHB in the brain, that enhanced brain penetration cannot account for potency differences between compounds, and that baclofen, like GHB, can readily cross the blood-brain barrier.

  10. A business case for on-site generation: The BD biosciences pharmingen project

    Energy Technology Data Exchange (ETDEWEB)

    Firestone, Ryan; Creighton, Charles; Bailey, Owen; Marnay, Chris; Stadler, Michael

    2003-09-01

    Deregulation is haltingly changing the United States electricity markets. The resulting uncertainty and/or rising energy costs can be hedged by generating electricity on-site and other benefits, such as use of otherwise wasted heat, can be captured. The Public Utility Regulatory Policy Act (PURPA) of 1978 first invited relatively small-scale generators ({ge} 1 MW) into the electricity market. The advent of efficient and reliable small scale and renewable equipment has spurred an industry that has, in recent years, made even smaller (business scale) electricity generation an economically viable option for some consumers. On-site energy capture and/or conversion, known as distributed energy resources (DER), offers consumers many benefits, such as economic savings and price predictability, improved reliability, control over power quality, and emissions reductions. Despite these benefits, DER adoption can be a daunting move to a customer accustomed to simply paying a monthly utility bill. San Diego is in many ways an attractive location for DER development: It has high electricity prices typical of California and a moderate climate i.e. energy loads are consistent throughout the year. Additionally, the price shock to San Diego Gas and Electric (SDG&E) customers during the summer of 2000 has interested many in alternatives to electricity price vulnerability. This report examines the business case for DER at the San Diego biotechnology supply company, BD Biosciences Pharmingen, which considered DER for a building with 200-300 kW base-load, much of which accommodates the refrigerators required to maintain chemicals. Because of the Mediterranean climate of the San Diego area and the high rate of air changes required due to on-site use of chemicals, modest space heating is required throughout the year. Employees work in the building during normal weekday business hours, and daily peak loads are typically about 500 kW.

  11. 13 CFR 124.110 - Do Native Hawaiian Organizations have any special rules for applying to the 8(a) BD program?

    Science.gov (United States)

    2010-01-01

    ...) BD program as its primary SIC code. (d) SBA does not deem an individual involved in the management or...: (i) The technical and managerial experience and competence of the individual(s) who will manage...

  12. Effect of chloride substitution on the order–disorder transition in NaBH{sub 4} and Na{sup 11}BD{sub 4}

    Energy Technology Data Exchange (ETDEWEB)

    Olsen, Jørn Eirik [Institute for Energy Technology, Physics Department, P.O. Box 40, NO-2027 Kjeller (Norway); Karen, Pavel [University of Oslo, Department of Chemistry, P.O. Box 1033 Blindern, NO-0315 Oslo (Norway); Sørby, Magnus H. [Institute for Energy Technology, Physics Department, P.O. Box 40, NO-2027 Kjeller (Norway); Hauback, Bjørn C., E-mail: bjorn.hauback@ife.no [Institute for Energy Technology, Physics Department, P.O. Box 40, NO-2027 Kjeller (Norway)

    2014-02-25

    Graphical abstract: Interactions that order the BD{sub 4}{sup -} tetrahedra below the order–disorder transition became increasingly frustrated by the solute in the Na({sup 11}BD{sub 4}){sub 1−x}Cl{sub x} solid solutions, and the order disappears at x = 0.158. Highlights: • The order–disorder transition temperature for Na(BH{sub 4}){sub 1−x}Cl{sub x} and Na({sup 11}BD{sub 4}){sub 1−x}Cl{sub x} is highly dependent on the Cl-content, x. • The transition is characterized by DSC for Na({sup 11}BD{sub 4}){sub 1−x}Cl{sub x} for x = 0, 0.10 and 0.15. • No transition is observed for x ⩾ 0.20 on cooling to 8 K. • The crystal structures are reported for Na{sup 11}BD{sub 4} at room temperature and 8 K and Na({sup 11}BD{sub 4}){sub 1−x}Cl{sub x} (x = 0.10, 0.15, 0.20 and 0.25) at 8 K from powder neutron diffraction. -- Abstract: Phase transition associated with anion disordering over two orientations in Na{sup 11}BD{sub 4} (NaBH{sub 4}) and its solid solutions with NaCl, Na({sup 11}BD{sub 4}){sub 1−x}Cl{sub x}, is investigated with powder diffraction (neutron and synchrotron radiation), differential scanning calorimetry and Raman spectroscopy. Upon heating, the transition temperature extrapolated to zero rate of heating is 192.2 K for Na{sup 11}BD{sub 4}, ΔS = 4.41 J/mol K, hysteresis 1.7 K and the volume increase 0.43%. Thermal parameters of the transition in Na({sup 11}BD{sub 4}){sub 1−x}Cl{sub x} follow a colligative-property model of an ideal solution, with x = 0.158(1) as the critical concentration at which the ordering interactions and the transition itself are eliminated. On approaching this limit, the tetragonal distortion of the ordered structure decreases somewhat towards the cubic average, and this is associated with a partial disorder of the tetrahedral anions seen by diffraction methods. In fact, a 3% disorder is already present in the pure solvent of the solid solution (Na{sup 11}BD{sub 4}) at 8 K.

  13. Neural processing of emotional facial and semantic expressions in euthymic bipolar disorder (BD and its association with theory of mind (ToM.

    Directory of Open Access Journals (Sweden)

    Agustin Ibanez

    Full Text Available BACKGROUND: Adults with bipolar disorder (BD have cognitive impairments that affect face processing and social cognition. However, it remains unknown whether these deficits in euthymic BD have impaired brain markers of emotional processing. METHODOLOGY/PRINCIPAL FINDINGS: We recruited twenty six participants, 13 controls subjects with an equal number of euthymic BD participants. We used an event-related potential (ERP assessment of a dual valence task (DVT, in which faces (angry and happy, words (pleasant and unpleasant, and face-word simultaneous combinations are presented to test the effects of the stimulus type (face vs word and valence (positive vs. negative. All participants received clinical, neuropsychological and social cognition evaluations. ERP analysis revealed that both groups showed N170 modulation of stimulus type effects (face > word. BD patients exhibited reduced and enhanced N170 to facial and semantic valence, respectively. The neural source estimation of N170 was a posterior section of the fusiform gyrus (FG, including the face fusiform area (FFA. Neural generators of N170 for faces (FG and FFA were reduced in BD. In these patients, N170 modulation was associated with social cognition (theory of mind. CONCLUSIONS/SIGNIFICANCE: This is the first report of euthymic BD exhibiting abnormal N170 emotional discrimination associated with theory of mind impairments.

  14. Epitope mapping and identification of amino acids critical for mouse IgG-binding to linear epitopes on Gly m Bd 28K.

    Science.gov (United States)

    Xi, Jun; Yan, Huili

    2016-10-01

    Gly m Bd 28K is one of the major allergens in soybeans, but there is limited information on its IgG-binding epitopes. Thirty-four overlapping peptides that covered the entire sequence of Gly m Bd 28K were synthesized, and 3 monoclonal antibodies against Gly m Bd 28K were utilized to identify the IgG-binding regions of Gly m Bd 28K. Three dominant peptides corresponding to (28)GDKKSPKSLFLMSNS(42)(G28-S42), (56)LKSHGGRIFYRHMHI(70)(L56-I70), and (154)ETFQSFYIGGGANSH(168)(E154-H168) were recognized. L56-I70 is the most important epitope, and a competitive ELISA indicated that it could inhibit the binding of monoclonal antibody to Gly m Bd 28K protein. Alanine scanning of L56-I70 documented that F64, Y65, and R66 were the critical amino acids of this epitope. Two bioinformatics tools, ABCpred and BepiPred, were used to predict the epitopes of Gly m Bd 28K, and the predictions were compared with the epitopes that we had located by monoclonal antibodies.

  15. Antiadhesive activity of the biosurfactant pseudofactin II secreted by the Arctic bacterium Pseudomonas fluorescens BD5

    Directory of Open Access Journals (Sweden)

    Janek Tomasz

    2012-02-01

    Full Text Available Abstract Background Pseudofactin II is a recently identified biosurfactant secreted by Pseudomonas fluorescens BD5, the strain obtained from freshwater from the Arctic Archipelago of Svalbard. Pseudofactin II is a novel compound identified as cyclic lipopeptide with a palmitic acid connected to the terminal amino group of eighth amino acid in peptide moiety. The C-terminal carboxylic group of the last amino acid forms a lactone with the hydroxyl of Thr3. Adhesion is the first stage of biofilm formation and the best moment for the action of antiadhesive and anti-biofilm compounds. Adsorption of biosurfactants to a surface e.g. glass, polystyrene, silicone modifies its hydrophobicity, interfering with the microbial adhesion and desorption processes. In this study the role and applications of pseudofactin II as a antiadhesive compound has been investigated from medicinal and therapeutic perspectives. Results Pseudofactin II lowered the adhesion to three types of surfaces (glass, polystyrene and silicone of bacterial strains of five species: Escherichia coli, Enterococcus faecalis, Enterococcus hirae, Staphylococcus epidermidis, Proteus mirabilis and two Candida albicans strains. Pretreatment of a polystyrene surface with 0.5 mg/ml pseudofactin II inhibited bacterial adhesion by 36-90% and that of C. albicans by 92-99%. The same concentration of pseudofactin II dislodged 26-70% of preexisting biofilms grown on previously untreated surfaces. Pseudofactin II also caused a marked inhibition of the initial adhesion of E. faecalis, E. coli, E. hirae and C. albicans strains to silicone urethral catheters. The highest concentration tested (0.5 mg/ml caused a total growth inhibition of S. epidermidis, partial (18-37% inhibition of other bacteria and 8-9% inhibition of C. albicans growth. Conclusion Pseudofactin II showed antiadhesive activity against several pathogenic microorganisms which are potential biofilm formers on catheters, implants and internal

  16. 基于GPS\BD2组合的车载导航系统性能分析%Analysis of vehicle navigation performance based on GPS/BD2 integration

    Institute of Scientific and Technical Information of China (English)

    高山; 赵永卿; 谭曦光

    2017-01-01

    The independent development of China’s BeiDou navigation system has already covered the Asia‐Pacific region .To study the performance accuracy of BeiDou system‐based vehicle navigation technology , this paper uses pseudo range single point positioning method to analyze their two‐dimensional positioning accuracy of three navigation modes GPS ,BD2 ,and GPS\\BD2 .The results show that accuracy shows 3.66 m ,4.76 m ,3.01 m ,of w hich the positioning accuracy of BeiDou navigation system based on single point positioning has reached 5 m inside , fully meetting the public daily travel requirements . And compared with GPS navigation system , the combined system has higher precision , so it’ s the best navigation mode .Besides ,writing positioning software based on visual studio platform ,can be used to extract the vehicle position and speed information to monitor w hether the vehicle exceed the speed limit .%中国独立发展的北斗系统已经具备亚太地区的定位导航能力,为研究以北斗系统为主的车载导航技术的应用精度,采用伪距单点定位的方法分别对车载GPS ,BD2,GPS\BD23种导航模式下的二维导航精度进行对比分析,结果显示定位精度分别为:3.66m,4.76m,3.01m,可以看出基于单点定位的北斗二维平面导航精度已达到5m内,完全满足大众日常的出行要求。组合系统与GPS导航系统对比,组合系统具有更高的精度,是较好的导航模式。并基于visual studio平台编写定位软件,实现对车辆位置和速度信息的提取,监控车辆是否超速。

  17. Characterization of the NTPR and BD1 interacting domains of the human PICH-BEND3 complex

    DEFF Research Database (Denmark)

    Pitchai, Ganesha P; Hickson, Ian D; Streicher, Werner

    2016-01-01

    Chromosome integrity depends on DNA structure-specific processing complexes that resolve DNA entanglement between sister chromatids. If left unresolved, these entanglements can generate either chromatin bridging or ultrafine DNA bridging in the anaphase of mitosis. These bridge structures...... are defined by the presence of the PICH protein, which interacts with the BEND3 protein in mitosis. To obtain structural insights into PICH-BEND3 complex formation at the atomic level, their respective NTPR and BD1 domains were cloned, overexpressed and crystallized using 1.56 M ammonium sulfate...

  18. $B_{d} \\to K^{*0}\\mu^{+}\\mu^{-}$ as a lab for discovering new physics at LHCb

    CERN Document Server

    Skottowe, Hugh

    2010-01-01

    The analysis of the penguin decay Bd->K*MuMu at LHCb can act as a laboratory for the discovery and understanding of new physics. Through the Operator Product Expansion, the decay kinematics are well understood in both the Standard Model and in a large range of new physics scenarios. The theoretical errors from QCD effects can be characterized and a set of observables have been derived which minimise their influence in measurements. We will describe how these measurements can be made in LHCb with special emphasis on what can be done with a first run of the LHC with a few hundred pb-1 of integrated luminosity.

  19. Development and evaluation of a real-time PCR assay for detection of Pneumocystis jirovecii on the fully automated BD MAX platform.

    Science.gov (United States)

    Dalpke, Alexander H; Hofko, Marjeta; Zimmermann, Stefan

    2013-07-01

    Pneumocystis jirovecii is an opportunistic pathogen in immunocompromised and AIDS patients. Detection by quantitative PCR is faster and more sensitive than microscopic diagnosis yet requires specific infrastructure. We adapted a real-time PCR amplifying the major surface glycoprotein (MSG) target from Pneumocystis jirovecii for use on the new BD MAX platform. The assay allowed fully automated DNA extraction and multiplex real-time PCR. The BD MAX assay was evaluated against manual DNA extraction and conventional real-time PCR. The BD MAX was used in the research mode running a multiplex PCR (MSG, internal control, and sample process control). The assay had a detection limit of 10 copies of an MSG-encoding plasmid per PCR that equated to 500 copies/ml in respiratory specimens. We observed accurate quantification of MSG targets over a 7- to 8-log range. Prealiquoting and sealing of the complete PCR reagents in conical tubes allowed easy and convenient handling of the BD MAX PCR. In a retrospective analysis of 54 positive samples, the BD MAX assay showed good quantitative correlation with the reference PCR method (R(2) = 0.82). Cross-contamination was not observed. Prospectively, 278 respiratory samples were analyzed by both molecular assays. The positivity rate overall was 18.3%. The BD MAX assay identified 46 positive samples, compared to 40 by the reference PCR. The BD MAX assay required liquefaction of highly viscous samples with dithiothreitol as the only manual step, thus offering advantages for timely availability of molecular-based detection assays.

  20. Measurement of the Ratios of Branching Fractions B(Bs -> Ds pi pi pi) / B(Bd -> Dd pi pi pi) and B(Bs -> Ds pi) / B(Bd -> Dd pi)

    CERN Document Server

    Abulencia, A; Affolder, T; Akimoto, T; Albrow, M G; Ambrose, D; Amerio, S; Amidei, D; Anastassov, A; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arguin, J F; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Azfar, F; Azzi-Bacchetta, P; Azzurri, P; Bacchetta, N; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Baroiant, S; Bartsch, V; Bauer, G; Bedeschi, F; Behari, S; Belforte, S; Bellettini, G; Bellinger, J; Belloni, A; Benjamin, D; Beretvas, A; Beringer, J; Berry, T; Bhatti, A; Binkley, M; Bisello, D; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bölla, G; Bolshov, A; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, Yu A; Budd, H S; Budd, S; Budroni, S; Burkett, K; Busetto, G; Bussey, P; Byrum, K L; Cabrera, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carillo, S; Carlsmith, D; Carosi, R; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chou, J P; Choudalakis, G; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Ciljak, M; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Coca, M; Compostella, G; Convery, M E; Conway, J; Cooper, B; Copic, K; Cordelli, M; Cortiana, G; Crescioli, F; Cuenca-Almenar, C; Cuevas-Maestro, J; Culbertson, R; Cully, J C; Cyr, D; D'Auria, S; D'Onofrio, M; Da Ronco, S; Dagenhart, D; Davies, T; De Barbaro, P; De Cecco, S; De Lentdecker, G; De Pedis, D; Deisher, A; Dell'Orso, Mauro; Delli Paoli, F; Demortier, L; Deng, J; Deninno, M; Derwent, P F; Di Giovanni, G P; Di Ruzza, B; Di Turo, P; Dionisi, C; Dittmann, J R; Donati, S; Donega, M; Dong, P; Donini, J; Dorigo, T; Dorr, C; Dube, S; Efron, J; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, I; Fedorko, W T; Feild, R G; Feindt, M; Fernández, J P; Field, R; Flanagan, G; Foland, A; Forrester, S; Foster, G W; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garberson, F; García, J E; Garfinkel, A F; Gay, C; Gerberich, H; Gerdes, D; Giagu, S; Giannetti, P; Gibson, A; Gibson, K; Gimmell, J L; Ginsburg, C; Giokaris, N; Giordani, M; Giromini, P; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Goldstein, J; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Griffiths, M; Grinstein, S; Grosso-Pilcher, C; Group, R C; Grundler, U; Guimarães da Costa, J; Gunay-Unalan, Z; Gómez, G; Gómez-Ceballos, G; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Hamilton, A; Han, B Y; Han, J Y; Handler, R; Happacher, F; Hara, K; Hare, M; Harper, S; Harr, R F; Harris, R M; Hartz, M; Hatakeyama, K; Hauser, J; Heijboer, A; Heinemann, B; Heinrich, J; Henderson, C; Herndon, M; Heuser, J; Hidas, D; Hill, C S; Hirschbuehl, D; Holloway, A; Hou, S; Houlden, M; Hsu, S C; Huffman, B T; Hughes, R E; Husemann, U; Huston, J; Höcker, A; Incandela, J R; Introzzi, G; Iori, M; Ishizawa, Y; Ivanov, A; Iyutin, B; James, E; Jang, D; Jayatilaka, B; Jeans, D; Jensen, H; Jeon, E J; Jindariani, S; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Karchin, P E; Kato, Y; Kemp, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Klute, M; Knuteson, B; Ko, B R; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kovalev, A; Kraan, A C; Kraus, J; Kravchenko, I; Kreps, M; Kroll, J; Krumnack, N; Kruse, M; Krutelyov, V; Kubo, T; Kuhlmann, S E; Kuhr, T; Kusakabe, Y; Kwang, S; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; LeCompte, T; Lee, J; Lee, S W; Lee, Y J; Lefèvre, R; Leonardo, N; Leone, S; Levy, S; Lewis, J D; Lin, C; Lin, C S; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, T; Lockyer, N S; Loginov, A; Loreti, M; Loverre, P F; Lu, R S; Lucchesi, D; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; MacQueen, D; Mack, P; Madrak, R; Maeshima, K; Makhoul, K; Maksimovic, P; Malde, S; Manca, G; Margaroli, F; Marginean, R; Marino, C; Marino, C P; Martin, A; Martin, M; Martin, V; Martínez, M; Maruyama, T; Mastrandrea, P; Masubuchi, T; Matsunaga, H; Mattson, M E; Mazini, R; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtälä, P; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Miao, T; Miladinovic, N; Miles, J; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyamoto, A; Moed, S; Moggi, N; Mohr, B; Moore, R; Morello, M; Movilla-Fernández, P A; Mukherjee, A; Mumford, R; Murat, P; Mäki, T; Müller, T; Mülmenstädt, J; Nachtman, J; Nagano, A; Naganoma, J; Nakano, I; Napier, A; Necula, V; Neu, C; Neubauer, M S; Nielsen, J; Nigmanov, T; Nodulman, L; Norniella, O; Nurse, E; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Oldeman, R; Orava, R; Pagliarone, C; Palencia, E; Papadimitriou, V; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, Aldo L; Phillips, T J; Piacentino, G; Piedra, J; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Portell, X; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohos, F; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Ranjan, N; Rappoccio, S; Reisert, B; Rekovic, V; Renton, P B; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Ruiz, A; Russ, J; Rusu, V; Saarikko, H; Sabik, S; Safonov, A; Saint-Denis, R; Sakumoto, W K; Salamanna, G; Salto, O; Saltzberg, D; Santi, L; Sarkar, S; Sartori, L; Sato, K; Savard, P; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, E E; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, A L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sfyrla, A; Shapiro, M D; Shears, T G; Shepard, P F; Sherman, D; Shimojima, M; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sinervo, P; Sisakian, A; Sjölin, J; Slaughter, A J; Slaunwhite, J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spinella, F; Spreitzer, T; Squillacioti, P; Stanitzki, M; Staveris-Polykalas, A; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Stuart, D; Suh, J S; Sukhanov, A; Sun, H; Suzuki, T; Sánchez, C; Söderberg, M; Taffard, A; Takashima, R; Takeuchi, Y; Takikawa, K; Tanaka, M; Tanaka, R; Tecchio, M; Teng, P K; Terashi, K; Thom, J; Thompson, A S; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Tourneur, S; Trischuk, W; Tsuchiya, R; Tsuno, S; Turini, N; Ukegawa, F; Unverhau, T; Uozumi, S; Usynin, D; Vallecorsa, S; Van Remortel, N; Varganov, A; Vataga, E; Velev, G; Veramendi, G; Veszpremi, V; Vidal, R; Vila, I; Vilar, R; Vine, T; Vollrath, I; Volobuev, I P; Volpi, G; Vázquez, F; Wagner, J; Wagner, P; Wagner, R G; Wagner, R L; Wagner, W; Wallny, R; Wang, S M; Warburton, A; Waschke, S; Waters, D; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Wright, T; Wu, X; Wynne, S M; Würthwein, F; Yagil, A; Yamamoto, K; Yamaoka, J; Yamashita, T; Yang, C; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zhang, X; Zhou, J; Zucchelli, S; Österberg, K

    2006-01-01

    Using 355 pb^-1 of data collected by the CDF II detector in \\ppbar collisions at sqrt{s} = 1.96 TeV at the Fermilab Tevatron, we study the fully reconstructed hadronic decays B -> D pi and B -> D pi pi pi. We present the first measurement of the ratio of branching fractions B(Bs -> Ds pi pi pi) / B(Bd -> Dd pi pi pi) = 1.05 pm 0.10 (stat) pm 0.22 (syst). We also update our measurement of B(Bs -> Ds pi) / B(Bd -> Dd pi) to 1.13 pm 0.08 (stat) pm 0.23 (syst) improving the statistical uncertainty by more than a factor of two. We find B(Bs -> Ds pi) = [3.8 pm 0.3 (stat) pm 1.3 (syst)] \\times 10^{-3} and B(Bs -> Ds pi pi pi) = [8.4 pm 0.8 (stat) pm 3.2 (syst)] \\times 10^{-3}.

  1. The orbital elements and physical properties of the eclipsing binary BD+36 3317, a probable member of $\\delta$ Lyr cluster

    CERN Document Server

    Kıran, E; Değirmenci, Ö L; Wolf, M; Nemravová, J; Šlechta, M; Koubský, P

    2016-01-01

    Context. The fact that eclipsing binaries belong to a stellar group is useful, because the former can be used to estimate distance and additional properties of the latter, and vice versa. Aims. Our goal is to analyse new spectroscopic observations of BD$+36^\\circ3317$ along with the photometric observations from the literature and, for the first time, to derive all basic physical properties of this binary. We aim to find out whether the binary is indeed a member of the $\\delta$ Lyr open cluster. Methods. The spectra were reduced using the IRAF program and the radial velocities were measured with the program SPEFO. The line spectra of both components were disentangled with the program KOREL and compared to a grid of synthetic spectra. The final combined radial-velocity and photometric solution was obtained with the program PHOEBE. Results. We obtained the following physical elements of BD$+36^\\circ3317$: $M_1 = 2.24\\pm0.07 M_{\\odot}$, $M_2 = 1.52\\pm0.03 M_{\\odot}$, $R_1 = 1.76\\pm0.01 R_{\\odot}$, $R_2 = 1.46\\pm...

  2. Hubble Space Telescope Near-Ultraviolet Spectroscopy of the Bright CEMP-no Star BD+44 493

    CERN Document Server

    Placco, Vinicius; Roederer, Ian; Cowan, John; Frebel, Anna; Filler, Dan; Ivans, Inese I; Lawler, James E; Schatz, Hendrik; Sneden, Christopher; Sobeck, Jennifer; Aoki, Wako; Smith, Verne

    2014-01-01

    We present an elemental-abundance analysis, in the near-ultraviolet (NUV) spectral range, for the extremely metal-poor star BD+44 493, a 9th magnitude sub-giant with [Fe/H] = -3.8 and enhanced carbon, based on data acquired with the Space Telescope Imaging Spectrograph on the Hubble Space Telescope. This star is the brightest example of a class of objects that, unlike the great majority of carbon-enhanced metal-poor (CEMP) stars, does not exhibit over-abundances of heavy neutron-capture elements (CEMP-no). In this paper, we validate the abundance determinations for a number of species that were previously studied in the optical region, and obtain strong upper limits for beryllium and boron, as well as for neutron-capture elements from zirconium to platinum, many of which are not accessible from ground-based spectra. The boron upper limit we obtain for BD+44 493, logeps(B) < -0.70, the first such measurement for a CEMP star, is the lowest yet found for very and extremely metal-poor stars. In addition, we ob...

  3. Search for Diffuse X-rays from the Bow Shock Region of Runaway Star BD+43$^\\circ$3654 with Suzaku

    CERN Document Server

    Terada, Yukikatsu; Bamba, Aya; Yamazaki, Ryo; Kouzu, Tomomi; Koyama, Shu; Seta, Hiromi

    2012-01-01

    The bow shocks of runaway stars with strong stellar winds of over 2000 km s$^{-1}$ can serve as particle acceleration sites. The conversion from stellar wind luminosity into particle acceleration power has an efficiency of the same order of magnitude as those in supernova remnants, based on the radio emission from the bow shock region of runaway star BD+43$^\\circ$3654 \\citep{Benaglia10}.If this object exhibits typical characteristics, then runaway star systems can contribute a non-negligible fraction of Galactic cosmic-ray electrons. To constrain the maximum energy of accelerated particles from measurements of possible non-thermal emissions in the X-ray band, Suzaku observed BD+43$^\\circ$3654 in April 2011 with an exposure of 99 ks. Because the onboard instruments have a stable and low background level, Suzaku detected a possible enhancement over the background of $7.6\\pm 3.4$ cnt arcmin$^{-2}$ at the bow shock region, where the error represents the 3 sigma statistics only. However, the excess is not signific...

  4. In vivo Cigarette Smoke Exposure Decreases CCL20, SLPI, and BD-1 Secretion by Human Primary Nasal Epithelial Cells

    Science.gov (United States)

    Jukosky, James; Gosselin, Benoit J.; Foley, Leah; Dechen, Tenzin; Fiering, Steven; Crane-Godreau, Mardi A.

    2016-01-01

    Smokers and individuals exposed to second-hand cigarette smoke have a higher risk of developing chronic sinus and bronchial infections. This suggests that cigarette smoke (CS) has adverse effects on immune defenses against pathogens. Epithelial cells are important in airway innate immunity and are the first line of defense against infection. Airway epithelial cells not only form a physical barrier but also respond to the presence of microbes by secreting antimicrobials, cytokines, and chemokines. These molecules can lyse infectious microorganisms and/or provide signals critical to the initiation of adaptive immune responses. We examined the effects of CS on antimicrobial secretions of primary human nasal epithelial cells (PHNECs). Compared to non-CS-exposed individuals, PHNEC from in vivo CS-exposed individuals secreted less chemokine ligand (C-C motif) 20 (CCL20), Beta-defensin 1 (BD-1), and SLPI apically, less BD-1 and SLPI basolaterally, and more CCL20 basolaterally. Cigarette smoke extract (CSE) exposure in vitro decreased the apical secretion of CCL20 and beta-defensin 1 by PHNEC from non-CS-exposed individuals. Exposing PHNEC from non-CS exposed to CSE also significantly decreased the levels of many mRNA transcripts that are involved in immune signaling. Our results show that in vivo or in vitro exposure to CS alters the secretion of key antimicrobial peptides from PHNEC, but that in vivo CS exposure is a much more important modifier of antimicrobial peptide secretion. Based on the gene expression data, it appears that CSE disrupts multiple immune signaling pathways in PHNEC. Our results provide mechanistic insight into how CS exposure alters the innate immune response and increases an individual’s susceptibility to pathogen infection. PMID:26793127

  5. Gi-protein-coupled 5-HT1B/D receptor agonist sumatriptan induces type I hyperalgesic priming.

    Science.gov (United States)

    Araldi, Dioneia; Ferrari, Luiz F; Levine, Jon D

    2016-08-01

    We have recently described a novel form of hyperalgesic priming (type II) induced by agonists at two clinically important Gi-protein-coupled receptors (Gi-GPCRs), mu-opioid and A1-adenosine. Like mu-opioids, the antimigraine triptans, which act at 5-HT1B/D Gi-GPCRs, have been implicated in pain chronification. We determined whether sumatriptan, a prototypical 5-HT1B/D agonist, produces type II priming. Characteristic of hyperalgesic priming, intradermal injection of sumatriptan (10 ng) induced a change in nociceptor function such that a subsequent injection of prostaglandin-E2 (PGE2) induces prolonged mechanical hyperalgesia. However, onset to priming was delayed 3 days, characteristic of type I priming. Also characteristic of type I priming, a protein kinase Cε, but not a protein kinase A inhibitor attenuated the prolongation phase of PGE2 hyperalgesia. The prolongation of PGE2 hyperalgesia was also permanently reversed by intradermal injection of cordycepin, a protein translation inhibitor. Also, hyperalgesic priming did not occur in animals pretreated with pertussis toxin or isolectin B4-positive nociceptor toxin, IB4-saporin. Finally, as observed for other agonists that induce type I priming, sumatriptan did not induce priming in female rats. The prolongation of PGE2 hyperalgesia induced by sumatriptan was partially prevented by coinjection of antagonists for the 5-HT1B and 5-HT1D, but not 5-HT7, serotonin receptors and completely prevented by coadministration of a combination of the 5-HT1B and 5-HT1D antagonists. Moreover, the injection of selective agonists, for 5-HT1B and 5-HT1D receptors, also induced hyperalgesic priming. Our results suggest that sumatriptan, which signals through Gi-GPCRs, induces type I hyperalgesic priming, unlike agonists at other Gi-GPCRs, which induce type II priming.

  6. BD Phoenix and Vitek 2 detection of mecA-mediated resistance in Staphylococcus aureus with cefoxitin.

    Science.gov (United States)

    Junkins, Alan D; Lockhart, Shawn R; Heilmann, Kristopher P; Dohrn, Cassie L; Von Stein, Diana L; Winokur, Patricia L; Doern, Gary V; Richter, Sandra S

    2009-09-01

    The BD Phoenix (BD Diagnostics, Sparks, MD) and Vitek 2 (bioMérieux, Durham, NC) automated susceptibility testing systems have implemented the use of cefoxitin to enhance the detection of methicillin (meticillin)-resistant Staphylococcus aureus (MRSA). To assess the impact of this change, 620 clinically significant S. aureus isolates were tested in parallel on Phoenix PMIC/ID-102 panels and Vitek 2 AST-GP66 cards. The results for oxacillin and cefoxitin generated by the automated systems were compared to those generated by two reference methods: mecA gene detection and MICs of oxacillin previously determined by broth microdilution according to CLSI guidelines. Testing of isolates with discordant results was repeated to attain a majority or consensus final result. There was 100% final agreement between the results of the two reference methods. For the 448 MRSA and 172 methicillin-susceptible S. aureus isolates tested, the rates of categorical agreement of the results obtained with the automated systems with those obtained by the reference methods were 99.8% for the Phoenix panels and 99.7% for the Vitek 2 cards. A single very major error occurred on each instrument (0.2%) with different MRSA isolates. The only major error was attributed to the Vitek 2 system overcalling oxacillin resistance. In 16 instances (9 on the Phoenix system, 7 on the Vitek 2 system), an oxacillin MIC in the susceptible range was correctly changed to resistant by the expert system on the basis of the cefoxitin result. The inclusion of cefoxitin in the Phoenix and Vitek 2 panels has optimized the detection of MRSA by both systems.

  7. Comparison of BD phoenix to vitek 2, microscan MICroSTREP, and Etest for antimicrobial susceptibility testing of Streptococcus pneumoniae.

    Science.gov (United States)

    Mittman, Scott A; Huard, Richard C; Della-Latta, Phyllis; Whittier, Susan

    2009-11-01

    The performance of the BD Phoenix Automated Microbiology System (BD Diagnostic Systems) was compared to those of the Vitek 2 (bioMérieux), the MicroScan MICroSTREP plus (Siemens), and Etest (bioMérieux) for antibiotic susceptibility tests (AST) of 311 clinical isolates of Streptococcus pneumoniae. The overall essential agreement (EA) between each test system and the reference microdilution broth reference method for S. pneumoniae AST results was >95%. For Phoenix, the EAs of individual antimicrobial agents ranged from 90.4% (clindamycin) to 100% (vancomycin and gatifloxacin). The categorical agreements (CA) of Phoenix, Vitek 2, MicroScan, and Etest for penicillin were 95.5%, 94.2%, 98.7%, and 97.7%, respectively. The overall CA for Phoenix was 99.3% (1 very major error [VME] and 29 minor errors [mEs]), that for Vitek 2 was 98.8% (7 VMEs and 28 mEs), and those for MicroScan and Etest were 99.5% each (19 and 13 mEs, respectively). The average times to results for Phoenix, Vitek 2, and the manual methods were 12.1 h, 9.8 h, and 24 h, respectively. From these data, the Phoenix AST results demonstrated a high degree of agreement with all systems evaluated, although fewer VMEs were observed with the Phoenix than with the Vitek 2. Overall, both automated systems provided reliable AST results for the S. pneumoniae-antibiotic combinations in half the time required for the manual methods, rendering them more suitable for the demands of expedited reporting in the clinical setting.

  8. 重组人BD3-BPI的内毒素中和活性及其在高盐环境中抗菌活性的稳定性%LPS Neutralization Activity and High-Salt Sensitivity of rhBD3-BPI

    Institute of Scientific and Technical Information of China (English)

    庹晓晔; 蒋伟; 李杰之; 柴家科; 郭希民

    2013-01-01

    Objective: To study the lipopolysaacharide(LPS) neutralization activity and high-salt sensitivity of rh-BD3-BPI, a recombinant human β-defensin 3(hBD3) and bactericidal permeability-increasing protein(BPI) fusion protein. Methods: Standard curve of LPS activity was created using Limulus Amebocyte Lasate test based on stan-dard LPS product. 100 μL serially diluted rhBD3-BPI was mixed with 100 μL 10 EU/mL LPS and incubated in water for 60 minutes at 37℃. 10 EU/mL LPS served as control and water served as blank control. 6×108 CFU/mL standard or clinically isolated wild Gram-positive or -negative bacterial strains were incubated at 37℃ for 3 h in 1 mg/mL rhBD3-BPI supplemented with 0~250 mmol/L of NaCl and then diluted at ratios from 1∶1 to 1∶1000 with 10 mmol/L sodium phosphate. 50 μL cells were plated in LB agar gel and incubated overnight, numbers of bacterial colonies were counted and bactericide rate was calculated. Results: In 5 EU/mL LPS system, LPS activi-ty neutralization was detected when rhBD3-BPI was above 4 μg/mL, 23% and 88% LPS neutralization rates were reached when rhBD3-BPI was 16 and 32 μg/mL, respectively. 50 μg/mL rhBD3-BPI had a 100% bactericidal ef-fect on all the strains. This effect was not influenced by increasing NaCl concentration before reaching 150 mmol/L. When the concentration of NaCl reached 200 mmol/L, the bactericidal effect remained above 90%. Significant decrease only appeared when the concentration of NaCl was above 200 mmol/L, however, the bactericidal effect of rhBD3- BPI remained above 85% even at the NaCl concentration of 250 mmol/L. Conclusion: rhBD3-BPI can neutralize LPS and has a stable bactericidal activity in high-salt solutions.%目的:验证重组人BD3-BPI(rhBD3-BPI)是否具有内毒素中和活性,研究其在高盐环境中是否能保持抗菌活性。方法:根据内毒素标准品绘制内毒素活性标准曲线,将100μL梯度稀释的rhBD3-BPI与100μL 10 EU

  9. Comparison of Chromogenic Media to BD GeneOhm Methicillin-Resistant Staphylococcus aureus (MRSA) PCR for Detection of MRSA in Nasal Swabs▿

    OpenAIRE

    Bischof, Larry J.; Lapsley, Linda; Fontecchio, Karen; Jacosalem, Dollie; Young, Carol; Hankerd, Rosemary; Newton, Duane W.

    2009-01-01

    To select a method for detecting methicillin-resistant Staphylococcus aureus (MRSA) in nasal swabs, we compared BD GeneOhm MRSA PCR and various culture media (mannitol salt agar with cefoxitin, MRSASelect, CHROMagar MRSA, and Spectra MRSA). While PCR detection of MRSA was more rapid, MRSASelect and Spectra MRSA demonstrated performance equivalent to that of PCR with maximal detection at 24 h.

  10. Expression of hBD-2 induced by 23-valent pneumococcal polysaccharide vaccine, Haemophilus influenzae type b vaccine and split influenza virus vaccine.

    Science.gov (United States)

    Shen, Zhenwei; Lei, Han

    2012-10-01

    Human β-defensin-2 (hBD-2) is an antimicrobial peptide with high activity and broad spectrum activity. hBD-2 expression may be highly elevated by microorganisms and inflammation. We reported that the majority of common vaccines used, including 23-valent pneumococcal polysaccharide vaccine, Haemophilus influenzae type b vaccine and split influenza virus vaccine, could induce the expression of hBD-2 in epithelial cells. Among them, the 23-valent pneumococcal polysaccharide vaccine was effective at a lower concentration (0.5 µg/ml), while Haemophilus influenzae type b vaccine and split influenza virus vaccine were effective at the concentration of 1 µg/ml. However, bacteriostatic experiments revealed that the split influenza virus vaccine was capable of inducing the highest antimicrobial activity. The medium of the 23-valent pneumococcal polysaccharide vaccine treatment group had a higher antimicrobial activity than the medium of the Haemophilus influenzae type b vaccine treatment group. The transcriptional regulator of hBD-2, that is, the NF-κB subunit, had a high level of activity, while the normal epithelial cells showed barely detectable activity, indicating that these vaccines have potential for clinical application.

  11. A dual mechanism involved in membrane and nucleic acid disruption of AvBD103b, a new avian defensin from the king penguin, against Salmonella enteritidis CVCC3377.

    Science.gov (United States)

    Teng, Da; Wang, Xiumin; Xi, Di; Mao, Ruoyu; Zhang, Yong; Guan, Qingfeng; Zhang, Jun; Wang, Jianhua

    2014-10-01

    The food-borne bacterial gastrointestinal infection is a serious public health threat. Defensins are evolutionarily conserved innate immune components with broad-spectrum antibacterial activity that do not easily induce resistance. AvBD103b, an avian defensin with potent activity against Salmonella enteritidis, was isolated from the stomach contents of the king penguin (Aptenodytes patagonicus). To elucidate further the antibacterial mechanism of AvBD103b, its effect on the S. enteritidis CVCC3377 cell membrane and intracellular DNA was researched. The cell surface hydrophobicity and a N-phenyl-1-naphthylamine uptake assay demonstrated that AvBD103b treatment increased the cell surface hydrophobicity and outer membrane permeability. Atomic absorption spectrometry, ultraviolet spectrophotometry, flow cytometry, and transmission electron microscopy (TEM) indicated that AvBD103b treatment can lead to the release of the cellular contents and cell death through damage of the membrane. DNA gel retardation and circular dichroism analysis demonstrated that AvBD103b interacted with DNA and intercalated into the DNA base pairs. A cell cycle assay demonstrated that AvBD103b affected cellular functions, such as DNA synthesis. Our results confirmed that AvBD103b exerts its antibacterial activity by damaging the cell membrane and interfering with intracellular DNA, ultimately causing cell death, and suggested that AvBD103b may be a promising candidate as an alternative to antibiotics against S. enteritidis.

  12. Repair of Staphylococcus aureus-infected wound with gene-modified C3H10T1/2 cells expressing BPI-BD3 fusion antibiotic peptide

    Directory of Open Access Journals (Sweden)

    Xin-ran ZHANG

    2015-10-01

    Full Text Available Objective To study the antibacterial and tissue reparative effect of BPI-BD3 gene-modified mesenchymal stem cells in a mouse model of wound infection. Methods C3H10T1/2 cells were transfected with recombinant adenovirus vector pAdxsi-BPI-BD3, the expression of BPI-BD3 fusion protein was verified by RT-PCR and Western blotting. Excision wound with a diameter of 1cm was inoculated with Staphylococcus aureuswas made on the back of 30 mice. The mice were randomly divided into 3 groups (10 each. Mice in group T were injected with BPI-BD3 gene-modified C3H10T1/2 cells through caudal vein, those in group C were injected with unmodified C3H10T1/2 cells, and in group N were injected with PBS as control. The wound repair result was evaluated by estimation of the percentage of remaining wound area and the amount of wound bacteria under the scar, followed by observation of pathological changes. Inflammatory reactions of the wounds were assessed accordingly. Results The amount of bacteria under the scar was less in group T than in the other two groups (P<0.05. It was also found that the wound healing process was faster in group T than in group C and group N. Pathological observation showed that the inflammatory reaction in group T was also significantly milder than in the other two groups. Conclusion BPI-BD3 gene-modified mesenchymal stem cells may enhance wound repair by controlling infection and promoting tissue regeneration, thus it may be promising in clinical application. DOI: 10.11855/j.issn.0577-7402.2015.09.07

  13. Clonidine Reduces Nociceptive Responses in Mouse Orofacial Formalin Model: Potentiation by Sigma-1 Receptor Antagonist BD1047 without Impaired Motor Coordination.

    Science.gov (United States)

    Yoon, Seo-Yeon; Kang, Suk-Yun; Kim, Hyun-Woo; Kim, Hyung-Chan; Roh, Dae-Hyun

    2015-01-01

    Although the administration of clonidine, an alpha-2 adrenoceptor agonist, significantly attenuates nociception and hyperalgesia in several pain models, clinical trials of clonidine are limited by its side effects such as drowsiness, hypotension and sedation. Recently, we determined that the sigma-1 receptor antagonist BD1047 dose-dependently reduced nociceptive responses in a mouse orofacial formalin model. Here we examined whether intraperitoneal injection of clonidine suppressed the nociceptive responses in the orofacial formalin test, and whether co-administration with BD1047 enhances lower-dose clonidine-induced anti-nociceptive effects without the disruption of motor coordination and blood pressure. Formalin (5%, 10 µL) was subcutaneously injected into the right upper lip, and the rubbing responses with the ipsilateral fore- or hind-paw were counted for 45 min. Clonidine (10, 30 or 100 µg/kg) was intraperitoneally administered 30 min before formalin injection. Clonidine alone dose-dependently reduced nociceptive responses in both the first and second phases. Co-localization for alpha-2A adrenoceptors and sigma-1 receptors was determined in trigeminal ganglion cells. Interestingly, the sub-effective dose of BD1047 (3 mg/kg) significantly potentiated the anti-nociceptive effect of lower-dose clonidine (10 or 30 µg/kg) in the second phase. In particular, the middle dose of clonidine (30 µg/kg) in combination with BD1047 produced an anti-nociceptive effect similar to that of the high-dose clonidine, but without a significant motor dysfunction or hypotension. In contrast, mice treated with the high dose of clonidine developed severe impairment in motor coordination and blood pressure. These data suggest that a combination of low-dose clonidine with BD1047 may be a novel and safe therapeutic strategy for orofacial pain management.

  14. BD PHOENIX-100全自动微生物鉴定仪对葡萄球菌鉴定能力的评价%Evaluation of the BD PHOENIX-100 Automated Microbiology System for Identification of Staphylococcus

    Institute of Scientific and Technical Information of China (English)

    王原; 曹俊敏; 陈益民; 许江燕

    2009-01-01

    [目的]评价BD PHOENIX-100全自动微生物鉴定仪(PHOENIX-100)对葡萄球菌的鉴定能力.[方法]收集从我院病人标本中分离的葡萄球菌81株.常规细菌培养后,用PHOENIX-100和API Staph系统进行检测,以API Staph系统为参照,评价PHOENIX-100的优势和不足.[结果]PHOENIX-100和API Staph系统的总体鉴定符合率为86.4%,其中金黄色葡萄球菌的鉴定符合率为100%,凝固酶阴性葡萄球菌的鉴定符合率为73.8%.[结论]PHOENIX-100鉴定系统能够基本满足临床工作的需求,其中对金黄色葡萄球菌的鉴定率较高,在进行凝固酶阴性葡萄球菌鉴定时有局限性.

  15. Analytical performance of RNA isolated from BD SurePath™ cervical cytology specimens by the PreTect™ HPV-Proofer assay.

    Science.gov (United States)

    Dixon, Eric P; Grønn, Petter; King, Lorraine M; Passineau, Heather; Doobay, Hema; Skomedal, Hanne; Hariri, Jalil; Hay, Shauna N; Brown, Charlotte A; Fischer, Timothy J; Malinowski, Douglas P

    2012-11-01

    Several commercial HPV ancillary tests are available for detection of E6/E7 RNA. It is not clear how storage of a cervical Pap affects the analytical and clinical performance of the PreTect™ HPV-Proofer assay. To investigate the qualitative performance of RNA extracted from BD SurePath™ liquid-based cytology (LBC) specimens for the detection of human papillomavirus (HPV) E6/E7 mRNA using the PreTect™ HPV-Proofer assay, studies including stability, reproducibility, residual specimen analysis, and storage medium comparison assays were performed. Cervical cytology specimens were collected and stored in BD SurePath™ LBC preservative fluid and/or PreTect™ Transport Media. RNA was isolated using the RecoverAll™ Total Nucleic Acid Isolation kit and RNA integrity was evaluated in the PreTect™ HPV-Proofer assay. The performance of RNA isolated from cervical cells collected and stored in BD SurePath™ LBC preservative fluid or PreTect™ Transport Media was also evaluated through a storage medium comparison study. The RNA was found to be stable for a minimum of 21 days when stored at ambient temperature and displayed high reproducibility with the mean percentage reproducibility ranging from 90.5% to 100% for the HPV types detected by the PreTect™ HPV-Proofer assay. The prevalence rate of HPV types in this study cohort was consistent with published reports. A 93.7% first pass acceptance rate was demonstrated across all cytology grades. The positive human U1 snRNP specific A protein (U1A) and HPV rate for BD SurePath™ LBC and PreTect™ Transport Media specimens was statistically equivalent for both normal and abnormal specimens. This data support the use of RNA isolated from BD SurePath™ LBC for ancillary HPV testing and demonstrates the feasibility of using BD SurePath™ preservative fluid as a specimen type with the PreTect™ HPV-Proofer assay.

  16. [Current knowledge on gamma-hydroxybutyric acid (GHB), gamma-butyrolactone (GBL) and 1 ,4-butanediol (1,4-BD)].

    Science.gov (United States)

    Dematteis, Maurice; Pennel, Lucie; Mallaret, Michel

    2012-05-01

    Gamma-hydroxybutyric acid (GHB) is an old anaesthetic drug which was misused in the 80-90's as an anabolic agent (bodybuilding), recreational drug (drunkenness, euphoric, disinhibiting and aphrodisiac effects) and as a date rape drug (disinhibiting, hypnotic and amnesic effects). Its use in the general population is low, and mainly concerns gay population in nightclubs and young people in parties. The intoxications, above all with alcohol combination, can be severe, with coma and breathing depression, or even fatal. Chronic use leads to psychic and physical dependence; withdrawal syndrome can be severe, with agitation and delirium. In 1999, GHB classification as a narcotic resulted in the increased use of GHB prodrugs gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD), which were easily commercially available as solvent and cleaning products. Like GHB, they have a narrow window of use, and share similar toxicity. Their increased cases of recreational use and of severe drug intoxication, abuse and dependence, led the French Ministry of Health in 2011 to prohibit their sale and transfer to the public.

  17. TRUMP-BD: A computer code for the analysis of nuclear fuel assemblies under severe accident conditions

    Energy Technology Data Exchange (ETDEWEB)

    Lombardo, N.J.; Marseille, T.J.; White, M.D.; Lowery, P.S.

    1990-06-01

    TRUMP-BD (Boil Down) is an extension of the TRUMP (Edwards 1972) computer program for the analysis of nuclear fuel assemblies under severe accident conditions. This extension allows prediction of the heat transfer rates, metal-water oxidation rates, fission product release rates, steam generation and consumption rates, and temperature distributions for nuclear fuel assemblies under core uncovery conditions. The heat transfer processes include conduction in solid structures, convection across fluid-solid boundaries, and radiation between interacting surfaces. Metal-water reaction kinetics are modeled with empirical relationships to predict the oxidation rates of steam-exposed Zircaloy and uranium metal. The metal-water oxidation models are parabolic in form with an Arrhenius temperature dependence. Uranium oxidation begins when fuel cladding failure occurs; Zircaloy oxidation occurs continuously at temperatures above 13000{degree}F when metal and steam are available. From the metal-water reactions, the hydrogen generation rate, total hydrogen release, and temporal and spatial distribution of oxide formations are computed. Consumption of steam from the oxidation reactions and the effect of hydrogen on the coolant properties is modeled for independent coolant flow channels. Fission product release from exposed uranium metal Zircaloy-clad fuel is modeled using empirical time and temperature relationships that consider the release to be subject to oxidation and volitization/diffusion ( bake-out'') release mechanisms. Release of the volatile species of iodine (I), tellurium (Te), cesium (Ce), ruthenium (Ru), strontium (Sr), zirconium (Zr), cerium (Cr), and barium (Ba) from uranium metal fuel may be modeled.

  18. Analysis of combined radial velocities and activity of BD+20 1790: evidence supporting the existence of a planetary companion

    CERN Document Server

    Hernán-Obispo, M; Gálvez-Ortiz, M C; Golovin, A; Barnes, J R; Jones, H R A; Kane, S R; Pinfield, D; Jenkins, J S; Petit, P; Anglada-Escudé, G; Marsden, S C; Catalán, S; Jeffers, S V; de Castro, E; Cornide, M; Garcés, A; Jones, M I; Gorlova, N; Andreev, M

    2015-01-01

    This paper presents the simultaneous Bayesian analysis of the radial velocity and activity indices for the K5Ve active star BD+20 1790, that was proposed to host a close-in massive planet by Hern\\'an-Obispo et al. (2010). The Bayesian analysis supports the hypothesis of a planetary companion. We present a new orbital solution after removing the two main contributions to the stellar jitter, one that varies with the photometric period and another that varies with the synodic period of the star+planet system. We use a new method to determine these jitter components, considering them as a second and third signals in the system. A discussion on possible magnetic star-planet-interaction is included, based on the Bayesian analysis of the activity indices. We propose two possible sources for flare events of this star: one related to the geometry of the system and the relative movement of the star+planet, and a second one purely stochastic source that is related to the evolution of stellar active regions. Also, we obs...

  19. Natural genetic transformation in Acinetobacter sp. BD413 Biofilms: introducing natural genetic transformation as a tool for bioenhancement of biofilm reactors

    Energy Technology Data Exchange (ETDEWEB)

    Hendrickx, L.

    2002-07-01

    This study focussed on the localization and quantification of natural genetic transformation using neutral and disadvantageous genes in monoculture biofilms to investigate gene transfer and expression of the transferred genes in the absence of a selective advantage. Data obtained by this investigation were regarded as initial steps for evaluating the applicability of adding catabolic traits into the indigenous bacterial community of biofilm reactors by in situ natural genetic transformation. Because Acinetobacter spp. strains are readily found in waste water treatment plants and because Acinetobacter sp. BD413 possesses a high effective level of competence, natural genetic transformation was investigated in monoculture Acinetobacter sp. BD413 biofilms. The genes used for transformation encoded for the green fluorescent protein (GFP) and its variants. Monitoring of transformation events were performed with the use of automated confocal laser scanning microscopy (CLSM) and semi automated digital image processing and analysis. (orig.)

  20. Evaluation for the withdrawal syndrome from gamma-hydroxybutyric acid (GHB), gamma-butyrolactone (GBL), and 1,4-butanediol (1,4-BD) in different rat lines.

    Science.gov (United States)

    Quang, Lawrence S; Colombo, Giancarlo; Lobina, Carla; Maccioni, Paola; Orru, Alessandro; Gessa, Gian Luigi; Maher, Timothy J; Carai, Mauro A M

    2006-08-01

    A severe and life-threatening gamma-hydroxybutyric acid (GHB) withdrawal syndrome, clinically similar to the alcohol withdrawal syndrome, is increasingly being reported in GHB addicts. We investigated for the occurrence of withdrawal in Wistar and Sprague-Dawley rats, and in the selectively bred lines of GHB-sensitive (GHB-S) and Sardinian alcohol-preferring (sP) rats, following chronic administration of GHB, gamma-butyrolactone (GBL), and/or 1,4-butanediol (1,4-BD). Using validated rodent alcohol withdrawal scoring scales, little to no spontaneous or pharmacologically precipitated withdrawal effects were observed in Wistar, Sprague-Dawley, or GHB-S rats. Conversely, sP rats displayed both spontaneous and precipitated audiogenic seizures following abrupt cessation of chronic GHB or 1,4-BD administration and following pharmacological challenge with the GABA(B) receptor-selective antagonist, SCH 50911, respectively.

  1. Increase in osmotolerance of Rhizobium fredii soybean isolate BD32 by the proB proA operon of Escherichia coli.

    Science.gov (United States)

    Neumivakin, L V; Solovjev, V P; Sokhansanj, A; Tilba, V A; Moseiko, N A; Shachbasian, R V; Piruzian, E S

    1995-12-26

    The proB proA operons (which are blocked by the feedback inhibition of proline production) of Escherichia coli wild type or with the mutation proBosm, blocking feedback inhibition effect of proline production, were cloned in a broad host range shuttle vector pVA 12-2. The hybrid plasmids pLVA(proB+A+) and pNSA(proBosm proA), were transferred into a low level osmotolerance Rhizobium fredii strain BD32. Both types of transconjugants were characterised by increased osmotolerance in a minimal medium supplied with 0.4-0.8 M NaCl but in the case of pNSA the effect was more significant. The strain BD32/pNSA had an increased level of intracellular proline concentration. Practical application of the increase in Rhizobium resistance to the stress factors is discussed.

  2. Molecular Docking Study Characterization of Rare Flavonoids at the Nac-Binding Site of the First Bromodomain of BRD4 (BRD4 BD1

    Directory of Open Access Journals (Sweden)

    Karthik Dhananjayan

    2015-01-01

    Full Text Available ε-N-Acetylation of lysine residues (Kac is one of the most frequently occurring posttranslational modifications (PTMs which control gene transcription and a vast array of diverse cellular functions. Bromodomains are epigenetic regulators involved in posttranslational modification. In silico docking studies were carried out to evaluate the binding potential of selected rare flavonoids on to Nac binding site of BD1 domain of BRD4 BET family proteins. Rare flavonoids like 3-O-acetylpinobanksin, naringenin triacetate, and kaempferol tetraacetate were found to occupy the WPF shelf and at the same time they exhibited a better binding affinity with multiple crystal structures of first bromodomain BRD4 (BRD4 BD1 when compared with the known inhibitors.

  3. Measurement of the angular and lifetime parameters of the decays Bd0-->J/psiK*0 and Bs0-->J/psiphi.

    Science.gov (United States)

    Abazov, V M; Abbott, B; Abolins, M; Acharya, B S; Adams, M; Adams, T; Aguilo, E; Ahsan, M; Alexeev, G D; Alkhazov, G; Alton, A; Alverson, G; Alves, G A; Anastasoaie, M; Ancu, L S; Andeen, T; Andrieu, B; Anzelc, M S; Aoki, M; Arnoud, Y; Arov, M; Arthaud, M; Askew, A; Asman, B; Assis Jesus, A C S; Atramentov, O; Avila, C; Badaud, F; Bagby, L; Baldin, B; Bandurin, D V; Banerjee, P; Banerjee, S; Barberis, E; Barfuss, A-F; Bargassa, P; Baringer, P; Barreto, J; Bartlett, J F; Bassler, U; Bauer, D; Beale, S; Bean, A; Begalli, M; Begel, M; Belanger-Champagne, C; Bellantoni, L; Bellavance, A; Benitez, J A; Beri, S B; Bernardi, G; Bernhard, R; Bertram, I; Besançon, M; Beuselinck, R; Bezzubov, V A; Bhat, P C; Bhatnagar, V; Biscarat, C; Blazey, G; Blekman, F; Blessing, S; Bloom, K; Boehnlein, A; Boline, D; Bolton, T A; Boos, E E; Borissov, G; Bose, T; Brandt, A; Brock, R; Brooijmans, G; Bross, A; Brown, D; Bu, X B; Buchanan, N J; Buchholz, D; Buehler, M; Buescher, V; Bunichev, V; Burdin, S; Burnett, T H; Buszello, C P; Butler, J M; Calfayan, P; Calvet, S; Cammin, J; Carrasco-Lizarraga, M A; Carrera, E; Carvalho, W; Casey, B C K; Castilla-Valdez, H; Chakrabarti, S; Chakraborty, D; Chan, K M; Chandra, A; Cheu, E; Chevallier, F; Cho, D K; Choi, S; Choudhary, B; Christofek, L; Christoudias, T; Cihangir, S; Claes, D; Clutter, J; Cooke, M; Cooper, W E; Corcoran, M; Couderc, F; Cousinou, M-C; Crépé-Renaudin, S; Cuplov, V; Cutts, D; Cwiok, M; da Motta, H; Das, A; Davies, G; De, K; de Jong, S J; De La Cruz-Burelo, E; De Oliveira Martins, C; DeVaughan, K; Déliot, F; Demarteau, M; Demina, R; Denisov, D; Denisov, S P; Desai, S; Diehl, H T; Diesburg, M; Dominguez, A; Dorland, T; Dubey, A; Dudko, L V; Duflot, L; Dugad, S R; Duggan, D; Duperrin, A; Dyer, J; Dyshkant, A; Eads, M; Edmunds, D; Ellison, J; Elvira, V D; Enari, Y; Eno, S; Ermolov, P; Evans, H; Evdokimov, A; Evdokimov, V N; Ferapontov, A V; Ferbel, T; Fiedler, F; Filthaut, F; Fisher, W; Fisk, H E; Fortner, M; Fox, H; Fu, S; Fuess, S; Gadfort, T; Galea, C F; Garcia, C; Garcia-Bellido, A; Garcia-Guerra, G A; Gavrilov, V; Gay, P; Geist, W; Geng, W; Gerber, C E; Gershtein, Y; Gillberg, D; Ginther, G; Gómez, B; Goussiou, A; Grannis, P D; Greenlee, H; Greenwood, Z D; Gregores, E M; Grenier, G; Gris, Ph; Grivaz, J-F; Grohsjean, A; Grünendahl, S; Grünewald, M W; Guo, F; Guo, J; Gutierrez, G; Gutierrez, P; Haas, A; Hadley, N J; Haefner, P; Hagopian, S; Haley, J; Hall, I; Hall, R E; Han, L; Harder, K; Harel, A; Hauptman, J M; Hays, J; Hebbeker, T; Hedin, D; Hegeman, J G; Heinson, A P; Heintz, U; Hensel, C; Herner, K; Hesketh, G; Hildreth, M D; Hirosky, R; Hobbs, J D; Hoeneisen, B; Hohlfeld, M; Hossain, S; Houben, P; Hu, Y; Hubacek, Z; Hynek, V; Iashvili, I; Illingworth, R; Ito, A S; Jabeen, S; Jaffré, M; Jain, S; Jakobs, K; Jarvis, C; Jesik, R; Johns, K; Johnson, C; Johnson, M; Johnston, D; Jonckheere, A; Jonsson, P; Juste, A; Kajfasz, E; Karmanov, D; Kasper, P A; Katsanos, I; Kau, D; Kaushik, V; Kehoe, R; Kermiche, S; Khalatyan, N; Khanov, A; Kharchilava, A; Kharzheev, Y M; Khatidze, D; Kim, T J; Kirby, M H; Kirsch, M; Klima, B; Kohli, J M; Komissarov, E V; Konrath, J-P; Kozelov, A V; Kraus, J; Kuhl, T; Kumar, A; Kupco, A; Kurca, T; Kuzmin, V A; Kvita, J; Lacroix, F; Lam, D; Lammers, S; Landsberg, G; Lebrun, P; Lee, W M; Leflat, A; Lellouch, J; Li, J; Li, L; Li, Q Z; Lietti, S M; Lim, J K; Lima, J G R; Lincoln, D; Linnemann, J; Lipaev, V V; Lipton, R; Liu, Y; Liu, Z; Lobodenko, A; Lokajicek, M; Love, P; Lubatti, H J; Luna-Garcia, R; Lyon, A L; Maciel, A K A; Mackin, D; Madaras, R J; Mättig, P; Magass, C; Magerkurth, A; Mal, P K; Malbouisson, H B; Malik, S; Malyshev, V L; Maravin, Y; Martin, B; McCarthy, R; Meijer, M M; Melnitchouk, A; Mendoza, L; Mercadante, P G; Merkin, M; Merritt, K W; Meyer, A; Meyer, J; Mitrevski, J; Mommsen, R K; Mondal, N K; Moore, R W; Moulik, T; Muanza, G S; Mulhearn, M; Mundal, O; Mundim, L; Nagy, E; Naimuddin, M; Narain, M; Naumann, N A; Neal, H A; Negret, J P; Neustroev, P; Nilsen, H; Nogima, H; Novaes, S F; Nunnemann, T; O'Dell, V; O'Neil, D C; Obrant, G; Ochando, C; Onoprienko, D; Oshima, N; Osman, N; Osta, J; Otec, R; Otero y Garzón, G J; Owen, M; Padley, P; Pangilinan, M; Parashar, N; Park, S-J; Park, S K; Parsons, J; Partridge, R; Parua, N; Patwa, A; Pawloski, G; Penning, B; Perfilov, M; Peters, K; Peters, Y; Pétroff, P; Petteni, M; Piegaia, R; Piper, J; Pleier, M-A; Podesta-Lerma, P L M; Podstavkov, V M; Pogorelov, Y; Pol, M-E; Polozov, P; Pope, B G; Popov, A V; Potter, C; Prado da Silva, W L; Prosper, H B; Protopopescu, S; Qian, J; Quadt, A; Quinn, B; Rakitine, A; Rangel, M S; Ranjan, K; Ratoff, P N; Renkel, P; Rich, P; Rijssenbeek, M; Ripp-Baudot, I; Rizatdinova, F; Robinson, S; Rodrigues, R F; Rominsky, M; Royon, C; Rubinov, P; Ruchti, R; Safronov, G; Sajot, G; Sánchez-Hernández, A; Sanders, M P; Sanghi, B; Savage, G; Sawyer, L; Scanlon, T; Schaile, D; Schamberger, R D; Scheglov, Y; Schellman, H; Schliephake, T; Schlobohm, S; Schwanenberger, C; Schwartzman, A; Schwienhorst, R; Sekaric, J; Severini, H; Shabalina, E; Shamim, M; Shary, V; Shchukin, A A; Shivpuri, R K; Siccardi, V; Simak, V; Sirotenko, V; Skubic, P; Slattery, P; Smirnov, D; Snow, G R; Snow, J; Snyder, S; Söldner-Rembold, S; Sonnenschein, L; Sopczak, A; Sosebee, M; Soustruznik, K; Spurlock, B; Stark, J; Stolin, V; Stoyanova, D A; Strandberg, J; Strandberg, S; Strang, M A; Strauss, E; Strauss, M; Ströhmer, R; Strom, D; Stutte, L; Sumowidagdo, S; Svoisky, P; Sznajder, A; Tanasijczuk, A; Taylor, W; Tiller, B; Tissandier, F; Titov, M; Tokmenin, V V; Torchiani, I; Tsybychev, D; Tuchming, B; Tully, C; Tuts, P M; Unalan, R; Uvarov, L; Uvarov, S; Uzunyan, S; Vachon, B; van den Berg, P J; Van Kooten, R; van Leeuwen, W M; Varelas, N; Varnes, E W; Vasilyev, I A; Verdier, P; Vertogradov, L S; Verzocchi, M; Vilanova, D; Villeneuve-Seguier, F; Vint, P; Vokac, P; Voutilainen, M; Wagner, R; Wahl, H D; Wang, M H L S; Warchol, J; Watts, G; Wayne, M; Weber, G; Weber, M; Welty-Rieger, L; Wenger, A; Wermes, N; Wetstein, M; White, A; Wicke, D; Williams, M; Wilson, G W; Wimpenny, S J; Wobisch, M; Wood, D R; Wyatt, T R; Xie, Y; Xu, C; Yacoob, S; Yamada, R; Yang, W-C; Yasuda, T; Yatsunenko, Y A; Yin, H; Yip, K; Yoo, H D; Youn, S W; Yu, J; Zeitnitz, C; Zelitch, S; Zhao, T; Zhou, B; Zhu, J; Zielinski, M; Zieminska, D; Zieminski, A; Zivkovic, L; Zutshi, V; Zverev, E G

    2009-01-23

    We present measurements of the linear polarization amplitudes and the strong relative phases that describe the flavor-untagged decays Bd0-->J/psiK*0 and Bs0-->J/psiphi in the transversity basis. We also measure the mean lifetime taus of the Bs0 mass eigenstates and the lifetime ratio taus/taud. The analyses are based on approximately 2.8 fb(-1) of data recorded with the D0 detector. From our measurements of the angular parameters we conclude that there is no evidence for a deviation from flavor SU(3) symmetry for these decays and that the factorization assumption is not valid for the Bd0-->J/psiK*0 decay.

  4. Development of a Real-Time PCR Protocol Requiring Minimal Handling for Detection of Vancomycin-Resistant Enterococci with the Fully Automated BD Max System.

    Science.gov (United States)

    Dalpke, Alexander H; Hofko, Marjeta; Zimmermann, Stefan

    2016-09-01

    Vancomycin-resistant enterococci (VRE) are an important cause of health care-associated infections, resulting in significant mortality and a significant economic burden in hospitals. Active surveillance for at-risk populations contributes to the prevention of infections with VRE. The availability of a combination of automation and molecular detection procedures for rapid screening would be beneficial. Here, we report on the development of a laboratory-developed PCR for detection of VRE which runs on the fully automated Becton Dickinson (BD) Max platform, which combines DNA extraction, PCR setup, and real-time PCR amplification. We evaluated two protocols: one using a liquid master mix and the other employing commercially ordered dry-down reagents. The BD Max VRE PCR was evaluated in two rounds with 86 and 61 rectal elution swab (eSwab) samples, and the results were compared to the culture results. The sensitivities of the different PCR formats were 84 to 100% for vanA and 83.7 to 100% for vanB; specificities were 96.8 to 100% for vanA and 81.8 to 97% for vanB The use of dry-down reagents and the ExK DNA-2 kit for extraction showed that the samples were less inhibited (3.3%) than they were by the use of the liquid master mix (14.8%). Adoption of a cutoff threshold cycle of 35 for discrimination of vanB-positive samples allowed an increase of specificity to 87.9%. The performance of the BD Max VRE assay equaled that of the BD GeneOhm VanR assay, which was run in parallel. The use of dry-down reagents simplifies the assay and omits any need to handle liquid PCR reagents.

  5. CP violation study in $Bd \\to J/\\Psi(\\mu\\mu) Ks(\\pi\\pi)$ decay, vertex reconstruction and muon identification for the LHCb experiment

    CERN Document Server

    Nunes-Pereira, C

    The LHCb experiment is to precise measurements of CP violation in B-meson system and to the study of B decays. This work describes the performance study for the LHCb measurement of sin (2beta) from Bd to J/Psi(mumu) Ks(pipi) CP asymmetry, the performance study for two vertex constrained fitting tools and the study of the contamination reduction in muon identification for LHCb.

  6. Determination of GHB and its precursors (GBL and 1,4-BD) in dietary supplements through the synthesis of their isotopologues and analysis by GC-MS method.

    Science.gov (United States)

    Rosi, Luca; Frediani, Piero; Bartolucci, Gianluca

    2013-02-23

    Gamma-hydroxybutyric acid (GHB) and its "pro-drugs", gamma-butyrolactone (GBL) and 1,4 butanediol (1,4-BD), are drugs of abuse with depressant effects on the central nervous system. Many analytical methods have been proposed for the quantitative determination of these compounds mainly in biological matrices but only few have been addressed to dietary supplements and foods. Facile synthesis of the GBL and 1,4-BD isotopologues are available by "one pot" Ru-catalyzed homogeneous deuteration of dicarboxylic acids. In this work we propose a new method for determination of GHB, GBL and 1,4-BD in commercially available dietary supplements, based on isotope dilution mass spectrometry (ID-MS). The procedure involves a simple extraction of sample with acidic acetonitrile and direct analysis by GC-ID-MS method without any purification or derivatization. Indeed, the proposed method takes advantage of the complete conversion of GHB (free acid or its salts) to GBL, allowing the quantification of GHB and its pro-drugs. Five levels for each calibration curve have been prepared by diluting working solutions of the analytes to obtain concentrations ranging from 1 to 20mg/mL. The validation procedures have shown an accuracy between 88% and 99% and a precision between 7.3% and 2.9% of each analyte in the sample matrix. Positive ions chemical ionization (PICI) have been employed to preserve the information on molecular ions and to improve specificity and sensitivity of quantitative determination.

  7. In addition to its antiviral and immunomodulatory properties, the zebrafish β-defensin 2 (zfBD2) is a potent viral DNA vaccine molecular adjuvant.

    Science.gov (United States)

    García-Valtanen, P; Martinez-Lopez, A; Ortega-Villaizan, M; Perez, L; Coll, J M; Estepa, A

    2014-01-01

    It is well known that β-defensins are key components of the host innate immune response against pathogens and potentially provide a link between innate and adaptive immunity. In zebrafish (Danio rerio), a vertebrate model species in numerous biomedical fields, three β-defensin isoforms were recently identified. To our knowledge, however, studies describing antimicrobial or immunomodulatory properties of any of the zebrafish β-defensins isoforms are absent today. Since it is indubitable that deepening the study of zebrafish β-defensins would be of interest in this work we investigated whether or not the zebrafish β-defensin 2 (zfBD2) has the antiviral properties described for their vertebrate counterparts. Our in vitro and in vivo studies showed that zfBD2 has antiviral activity, immunomodulatory properties and, most importantly, is a potent viral DNA vaccine molecular adjuvant. In addition, a potential relationship between zfBD2 activity and the NF-κB signaling pathway is suggested. Altogether these results show that the zebrafish could be a suitable in vivo animal model to study the roles played by β-defensin 2 in viral diseases, vaccinology and even in clinical dermatology. To note that psoriasis can be induced in zebrafish and the over-expression of β-defensin 2 is implicated in the inflammatory response associated with this human skin disorder.

  8. A multiwavelength approach to BD+53$^\\circ$2790: the O9.5V counterpart to the X-ray binary system 4U~2206+54

    CERN Document Server

    Blay, Pere

    2011-01-01

    The X-ray binary system 4U 2206+54 hides many mysteries. Among them, the surprising behavior of both of its components: the O9.5 dwarf star BD+53$^\\circ$2790 and a slowly rotating neutron star. BD+53$^\\circ$2790 misled the astronomers showing itself very likely as a Be star. However, a deeper spectral analysis and more intense monitoring, revealed that the real picture was a bit more complicated: a) Although it shows evidence of a circumstellar envelope, its observable properties differ from those typical envelopes in Be stars. b) Comparison with spectral standards and models indicates a possible over-abundance in He. This would open the possibility to link the behavior of BD+53$^\\circ$2790 to the He-rich class of stars. c) UV spectra shows an abnormally slow and dense wind for an O9.5V star. d) Spectral classification in the IR wavelength region suggest a more likely supergiant nature of the source, in contradiction with the optical classification. e) The presence of an intense magnetic field is under invest...

  9. Guillem Peire de Cazals, “Be·m plagr’ueymais qu’ab vos dona·m valgues” (BdT 227.6

    Directory of Open Access Journals (Sweden)

    Alessio Collura

    2011-12-01

    Full Text Available This paper proposes a new edition with commentary of the poem “Be·m plagr’ueymais qu’ab vos, dona, ·m valgues” by Guillem Peire de Cazals and represents a first critical and hermeneutical reassessment of the poetry of the troubadour from Cahors, that has long been neglected. The text presents the classical structure of a love-story (springtime exordium, singing brought on by love, the theme of improvement, courting with no hope of a reward, a request for mercé and invites the fin aman to be patient. The song is examined from the viewpoint of its metrical and stylistic relations to other troubadour poems (Bernart de Ventadorn, “Can par la flors josta·l vert folh” [BdT 70.41] and “La dousa votz ai auzida” [BdT 70.23] and Lanfranc Cigala, “Ioios d’amor farai de ioi senblan” [BdT 282.12], and represents an early example of the mannerisms and experimental tendencies that characterize Guillem Peire’s poems. The article also attempts to date the composition to the twenties or thirties of the 13th century.

  10. BD2/GPS四频高精度接收机在远望号船姿测量中的应用%Attitude Measurement with High-Precision Dual-System Quad-Frequency BD2/GPS Receiver in Yuanwang Surveying Ship

    Institute of Scientific and Technical Information of China (English)

    周健; 毛刚; 赵李健; 王珏

    2012-01-01

    With the gradual improvement of the construction of Beidou satellite navigation system and the rapid spread of the Beidou application, BD2/GPS positioning terminal equipment has been widely used in various fields. The attitude measurement with high-precision dual-system quad-frequency BD2/GPS receiver in the o-cean-going surveying ship was described, and the attitude determination accuracy with the traditional single GPS receiver was compared, the analysis of the Beidou satellite system's role in attitude measurement and the advantages was made.%随着我国北斗卫星导航系统建设的逐步完善以及北斗应用的迅速推广,BD2/GPS定位终端设备已经开始广泛地应用于各个领域中.介绍了BD2/GPS双系统四频高精度接收机在远望号测量船船姿测量中的应用;并与传统的单一GPS接收机的测姿精度进行比对,分析北斗卫星导航系统在姿态测量中的作用与优势.

  11. The orbital elements and physical properties of the eclipsing binary BD+36°3317, a probable member of δ Lyrae cluster

    Science.gov (United States)

    Kıran, E.; Harmanec, P.; Değirmenci, Ö. L.; Wolf, M.; Nemravová, J.; Šlechta, M.; Koubský, P.

    2016-03-01

    Context. The fact that eclipsing binaries belong to a stellar group is useful, because the former can be used to estimate distance and additional properties of the latter, and vice versa. Aims: Our goal is to analyse new spectroscopic observations of BD+ 36°3317 along with the photometric observations from the literature and, for the first time, to derive all basic physical properties of this binary. We aim to find out whether the binary is indeed a member of the δ Lyr open cluster. Methods: The spectra were reduced using the IRAF program and the radial velocities were measured with the program SPEFO. The line spectra of both components were disentangled with the program KOREL and compared to a grid of synthetic spectra. The final combined radial-velocity and photometric solution was obtained with the program PHOEBE. Results: We obtained the following physical elements of BD+36°3317: M1 = 2.24 ± 0.07 M⊙, M2 = 1.52 ± 0.03 M⊙, R1 = 1.76 ± 0.01 R⊙, R2 = 1.46 ± 0.01 R⊙, log L1 = 1.52 ± 0.08 L⊙, log L2 = 0.81 ± 0.07 L⊙. We derived the effective temperatures Teff,1 = 10 450 ± 420 K, Teff,2 = 7623 ± 328 K. Both components are located close to zero age main sequence in the Hertzsprung-Russell (HR) diagram and their masses and radii are consistent with the predictions of stellar evolutionary models. Our results imply the average distance to the system d̅ = 330 ± 29 pc. We re-investigated the membership of BD+ 36°3317 in the δ Lyr cluster and confirmed it. The distance to BD+ 36°3317, given above, therefore represents an accurate estimate of the true distance for δ Lyr cluster. Conclusions: The reality of the δ Lyr cluster and the cluster membership of BD+ 36°3317 have been reinforced.

  12. Fritz-Peter Hager/Daniel Tröhler (Hrsg.): Neue Pestalozzi-Studien. Bd. 1: Anna Pestalozzis Tagebuch - Käte Silber: Anna Pestalozzi und der Frauenkreis um Pestalozzi. Bern/Stuttgart: Haupt 1993 [Rezension

    OpenAIRE

    Liedtke, Max

    1994-01-01

    Rezension von: Fritz-Peter Hager/Daniel Tröhler (Hrsg.): Neue Pestalozzi-Studien. Bd. 1: Anna Pestalozzis Tagebuch - Käte Silber: Anna Pestalozzi und der Frauenkreis um Pestalozzi. Bern/Stuttgart: Haupt 1993, 242 S.

  13. Genital and extra-genital screening for gonorrhoea using the BD Probetec ET system with an in-house PCR method targeting the porA pseudogene as confirmatory test

    DEFF Research Database (Denmark)

    Skovgaard, Sissel; Larsen, Helle Kiellberg; Sand, Carsten;

    2012-01-01

    for Chlamydia trachomatis testing were also examined for GC on the BD Viper™ platform using the BD Probetec ET system. In order to avoid false-positive results all GC BD reactive samples were re-tested using a PCR method with the porA pseudogene as target. Using this method we screened 170% more samples for GC...... than in the previous year, in the same population, and diagnosed more than twice as many GC-positive episodes. The BD system can be used successfully to screen extra-genital as well as genital specimen types for GC in a low-prevalence area if it is combined with a validated confirmatory PCR test....

  14. Svingningsteori, Bd. 1

    DEFF Research Database (Denmark)

    Nielsen, Søren R. K.

    Nærværende lærebog er skrevet med henblik på undervisningen i lineær svingingsteori på konstruktionsliniens 8. semester på Aalborg Universitetscenter. Det pågældende kursus danner grundlaget for efterfølgende undervisning i ikke-lineær svingningsteori, hvilket har påvirket fremstillingens form. D...

  15. [Jörg Zägel (in Zusammenarbeit mit Reiner Steinweg). Vergangenheitsdiskurse in der Ostseeregion. Bd. 1. Auseinandersetzungen in den nordischen Staaten über Krieg. Völkermord, Diktatur, Besatzung und Vertreibung; B. 2 : Die Sicht auf Krieg, Diktat

    Index Scriptorium Estoniae

    Hecker-Stampehl, Jan

    2011-01-01

    Arvustus : Jörg Zägel (in Zusammenarbeit mit Reiner Steinweg). Vergangenheitsdiskurse in der Ostseeregion. Bd. 1. Auseinandersetzungen in den nordischen Staaten über Krieg. Völkermord, Diktatur, Besatzung und Vertreibung. Berlin : LIT Verlag, 2007. (Kieler Schriften zur Friedenswissenschaft. 14); Bd. 2 : Die Sicht auf Krieg, Diktatur, Völkermord, Besatsung und Vertreibung in Russland, Polen und den baltischen Staaten. Berlin: Lit Verlag, 2007. (Kieler Schriften zur Friedenswissenschaft. 15)

  16. 基于三步逼近的BD2高精度快速捕获算法研究%High-accuracy fast acquisition algorithm research for BD2 signals based on three-step approximation

    Institute of Scientific and Technical Information of China (English)

    林智吉; 易清明; 石敏

    2015-01-01

    For low accuracy and heavy computation in acquisition module of BeiDou-2 navigation satellite system software receiver, a high accuracy and fast acquisition algorithm based on three-step approximation is proposed. Based on variable-step three-step approximation for narrowing search range of Doppler frequency shift gradually, it quickly acquires accurate initial code phase and Doppler frequency offset. Frequency circular shift is used to reduce computation burden of acquisition module by replacing FFT operations with one multiplication in the first step. Experimental results show that accurate Pseudo-Random Noise(PRN)code offset and carrier frequency error within 100 Hz can be acquired. Compared to the computation amount of traditional parallel code phase algorithm, it is reduced by average 70.56%in the optimal circumstances.%针对BeiDou-2(BD2)卫星导航软件接收机捕获模块中捕获精度低和运算量大的问题,提出了一种基于三步逼近的高精度快速捕获算法。算法采用变步长的三步逼近方法逐步缩小多普勒频移搜索范围,快速得到了精确的初始码相位和多普勒频偏;利用频率圆周移位方法,在第一步搜索以一次乘法代替FFT操作,较大地减少了捕获模块的运算负担。实验结果证明,该算法捕获的伪码偏移精确、载频偏移误差在100 Hz以内,且最优情况下的运算量比传统的并行码相位捕获算法平均减少了70.56%,运算效率高。

  17. Comparative study of equimolar doses of gamma-hydroxybutyrate (GHB), 1,4-butanediol (1,4-BD) and gamma-butyrolactone (GBL) on catalepsy after acute and chronic administration.

    Science.gov (United States)

    Towiwat, Pasarapa; Phattanarudee, Siripan; Maher, Timothy J

    2013-01-01

    Gamma-hydroxybutyrate (GHB), and its precursors 1,4-butanediol (1,4-BD) and gamma-butyrolactone (GBL) are known drugs of abuse. The ability of acute and chronic administration of equimolar doses of GHB (200mg/kg), 1,4-BD (174mg/kg) and GBL (166mg/kg) to produce catalepsy in male Swiss Webster mice was examined. GHB, 1,4-BD, GBL produced catalepsy when injected acutely. Drug treatment was then continued for 14days. Tolerance development was determined on days 6, 14, and challenged with a higher dose on day 15 in those chronically pretreated mice, and compared with naïve mice. Chronic GHB produced tolerance to catalepsy, as evidenced from area under the curve (AUC) of catalepsy versus time (min-sec) on days 6 (678±254), 14 (272±247), which were less than those on day 1 (1923±269). However, less tolerance was seen from GBL or 1,4-BD, as AUCs on days 6 and 14 were not significantly lower than that of day 1. In conclusion, although equimolar doses were used, expecting similar levels of GHB in the body, 1,4-BD and GBL shared only some of the in vivo effects of GHB. The rate of metabolic conversion of 1,4-BD and GBL into GHB might be responsible for the differences in the tolerance development to these drugs.

  18. Search for Bs->mu+mu- and Bd->mu+mu- Decays in ppbar Collisions at $\\sqrt{s}$=1.96 TeV

    CERN Document Server

    Acosta, D; Akimoto, T; Albrow, M G; Ambrose, D; Amerio, S; Amidei, D; Anastassov, A; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arguin, J F; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Azfar, F; Azzi-Bacchetta, P; Bacchetta, N; Bachacou, H; Badgett, W; Barbaro-Galtieri, A; Barker, G J; Barnes, V E; Barnett, B A; Baroiant, S; Barone, M; Bauer, G; Bedeschi, F; Behari, S; Belforte, S; Bellettini, Giorgio; Bellinger, J; Benjamin, D; Beretvas, A; Bhatti, A A; Binkley, M; Bisello, D; Bishai, M; Blair, R E; Blocker, C; Bloom, K; Blumenfeld, B; Bocci, A; Bodek, A; Bölla, G; Bolshov, A; Booth, P S L; Bortoletto, Daniela; Boudreau, J; Bourov, S; Bromberg, C; Brubaker, E; Budagov, Yu A; Budd, H S; Burkett, K; Busetto, G; Bussey, P; Byrum, K L; Cabrera, S; Calafiura, P; Campanelli, M; Campbell, M; Canepa, A; Carlsmith, D; Carosi, R; Carron, S; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cerri, A; Cerri, C; Cerrito, L; Chapman, J; Chen, C; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chu, M L; Chuang, S; Chung, J Y; Chung, W H; Chung, Y S; Ciobanu, C I; Ciocci, M A; Clark, A G; Clark, D; Coca, M; Connolly, A; Convery, M; Conway, J; Cordelli, M; Cortiana, G; Cranshaw, J; Cuevas-Maestro, J; Culbertson, R; Currat, C; Cyr, D; D'Auria, S; D'Onofrio, M; Da Ronco, S; Dagenhart, D; De Barbaro, P; De Cecco, S; De Lentdecker, G; De Pedis, D; Dell'Agnello, S; Dell'Orso, Mauro; Demers, S; Demortier, L; Deninno, M; Derwent, P F; Devlin, T; Dionisi, C; Dittmann, J R; Doksus, P; Dominguez, A; Donati, S; Donega, M; Dorigo, T; Drollinger, V; Ebina, K; Eddy, N; Ely, R; Erbacher, R; Erdmann, M; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, I; Feild, R G; Feindt, M; Fernández, J P; Ferretti, C; Field, R D; Fiori, I; Flanagan, G; Flaugher, B; Flores-Castillo, L R; Foland, A D; Forrester, S; Foster, G W; Franklin, M; Frisch, H; Fujii, Y; Furic, I; Gajjar, A; Gallas, A; Gallinaro, M; Galyardt, J; Garcia-, M; Garfinkel, A F; Gay, C; Gerberich, H; Gerchtein, E; Gerdes, D W; Giagu, S; Giannetti, P; Gibson, A; Gibson, K; Ginsburg, C; Giolo, K; Giordani, M; Giurgiu, G; Glagolev, V; Glenzinski, D A; Gold, M; Goldschmidt, N; Goldstein, D; Goldstein, J; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Gotra, Yu; Goulianos, K; Gresele, A; Grosso-Pilcher, C; Guimarães da Costa, J; Gómez, G; Gómez-Ceballos, G; Günther, M; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Handler, R; Happacher, F; Hara, K; Hare, M; Harr, R F; Harris, R M; Hartmann, F; Hatakeyama, K; Hauser, J; Hays, C; Hayward, H; Heider, E; Heinemann, B; Heinrich, J; Hennecke, M; Herndon, M; Hill, C; Hirschbuehl, D; Hoffman, K D; Holloway, A; Hou, S; Houlden, M A; Huang, Y; Huffman, B T; Hughes, R E; Huston, J; Höcker, A; Ikado, K; Incandela, J R; Introzzi, G; Iori, M; Ishizawa, Y; Issever, C; Ivanov, A; Iwata, Y; Iyutin, B; James, E; Jang, D; Jarrell, J; Jeans, D; Jensen, H; Jeon, E J; Jones, M; Joo, K K; Jun, S; Junk, T R; Kamon, T; Kang, J; Karagoz-Unel, M; Karchin, P E; Kartal, S; Kato, Y; Kemp, Y; Kephart, R D; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, M S; Kim, S B; Kim, S H; Kim, T H; Kim, Y K; King, B T; Kirby, M; Kirsch, L; Klimenko, S; Knuteson, B; Ko, B R; Kobayashi, H; Koehn, P; Kondo, K; Kong, D J; Konigsberg, J; Kordas, K; Korn, A J; Korytov, A; Kotelnikov, K A; Kotwal, A V; Kovalev, A; Kraus, J; Kravchenko, I; Kreymer, A; Kroll, J; Kruse, M; Krutelyov, V; Kuhlmann, S E; Kuznetsova, N; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, J; Lancaster, M; Lander, R; Lannon, K; Lath, A; Latino, G; Lauhakangas, R; Lazzizzera, I; Le, Y; LeCompte, T J; Lecci, C; Lee, J; Lee, S W; Leonardo, N; Leone, S; Lewis, J D; Li, K; Lin, C; Lin, C S; Lindgren, M; Liss, T M; Litvintsev, D O; Liu, T; Liu, Y; Lockyer, N S; Loginov, A; Loreti, M; Loverre, P F; Lu, R S; Lucchesi, D; Lukens, P; Lyons, L; Lys, J; Lysak, R; MacQueen, D; Madrak, R; Maeshima, K; Maksimovic, P; Malferrari, L; Manca, G; Marginean, R; Martin, A; Martin, M; Martin, V; Martínez, M; Maruyama, T; Matsunaga, H; Mattson, M E; Mazzanti, P; McFarland, K S; McGivern, D; McIntyre, P M; McNamara, P; McNulty, R; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Miao, T; Miladinovic, N; Miller, J S; Miller, L; Miller, R; Miquel, R; Miscetti, S; Mitselmakher, G; Miyamoto, A; Miyazaki, Y; Moggi, N; Mohr, B; Moore, R; Morello, M; Moulik, T; Mukherjee, A; Mulhearn, M; Mumford, R; Munar, A; Murat, P; Müller, T; Nachtman, J; Nahn, S; Nakamura, I; Nakano, I; Napier, A; Napora, R; Naumov, D V; Necula, V; Nelson, C; Nelson, T; Neu, C; Neubauer, M S; Newman-Holmes, C; Nicollerat, A S; Niell, F; Nielsen, J; Nigmanov, T; Nodulman, L; Ogawa, T; Oh, S; Oh, Y D; Ohsugi, T; Okusawa, T; Oldeman, R G C; Orava, Risto; Orejudos, W; Pagliarone, C; Palmonari, F; Paoletti, R; Papadimitriou, V; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Pauly, T; Paus, C; Pellett, D; Penzo, Aldo L; Phillips, T J; Piacentino, G; Piedra, J; Pitts, K T; Plager, C; Pompos, A; Pondrom, L; Pope, G; Poukhov, O; Prakoshyn, F; Pratt, T; Pronko, A G; Proudfoot, J; Ptohos, F; Punzi, G; Rademacker, J; Rakitine, A; Rappoccio, S; Ratnikov, F; Ray, H; Reichold, A; Rekovic, V; Renton, P B; Rescigno, M; Rimondi, F; Rinnert, K; Ristori, L; Robertson, W J; Robson, A; Rodrigo, T; Rolli, S; Rosenson, L; Roser, R; Rossin, R; Rott, C; Ruiz, A; Russ, J; Ryan, D; Saarikko, H; Safonov, A; Saint-Denis, R; Sakumoto, W K; Salamanna, G; Saltzberg, D; Sansoni, A; Santi, L; Sarkar, S; Sato, K; Savard, P; Schemitz, P; Schlabach, P; Schmidt, E E; Schmidt, M P; Schmitt, M; Sciveres; Scodellaro, L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semeria, F; Sexton-Kennedy, L; Sfiligoi, I; Shapiro, M D; Shears, T G; Shepard, P F; Shimojima, M; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Siket, M; Sill, A; Sinervo, P; Sissakian, A N; Skiba, A; Slaughter, A J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Somalwar, S V; Spalding, J; Spezziga, M; Spiegel, L; Spinella, F; Spiropulu, M; Squillacioti, P; Stadie, H; Stefanini, A; Stelzer, B; Stelzer-Chilton, O; Strologas, J; Stuart, D; Sukhanov, A; Sumorok, K; Sun, H; Suzuki, T; Sánchez, C; Taffard, A C; Tafirout, R; Takach, S F; Takano, H; Takashima, R; Takeuchi, Y; Takikawa, K; Tanaka, M; Tanaka, R; Tanimoto, N; Tapprogge, Stefan; Tecchio, M; Teng, P K; Terashi, K; Tesarek, R J; Tether, S; Thom, J; Thompson, A S; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tollefson, K; Tonelli, D; Tonnesmann, M; Torre, S; Torretta, D; Trischuk, W; Tseng, J; Tsuchiya, R; Tsuno, S; Tsybychev, D; Turini, N; Turner, M; Ukegawa, F; Unverhau, T; Uozumi, S; Usynin, D; Vacavant, L; Vaiciulis, A W; Varganov, A; Vataga, E; Vejcik, S; Velev, G V; Veramendi, G; Vickey, T; Vidal, R; Vila, I; Vilar, R; Volobuev, I P; Von der Mey, M; Wagner, R G; Wagner, R L; Wagner, W; Wallny, R; Walter, T; Wan, Z; Wang, M J; Wang, S M; Warburton, A; Ward, B; Waschke, S; Waters, D; Watts, T; Weber, M; Wester, W C; Whitehouse, B; Wicklund, A B; Wicklund, E; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolter, M; Worcester, M; Worm, S; Wright, T; Wu, X; Wyatt, A; Würthwein, F; Yagil, A; Yamamoto, K; Yamashita, T; Yang, U K; Yao, W; Yeh, G P; Yi, K; Yoh, J K; Yoon, P; Yorita, K; Yoshida, T; Yu, I; Yu, S; Yu, Z; Yun, C; Zanello, L; Zanetti, A; Zaw, I; Zetti, F; Zhou, J; Zsenei, A; Zucchelli, S; Österberg, K

    2004-01-01

    We report on a search for Bs->mu+mu- and Bd->mu+mu- decays in ppbar collisions at $\\sqrt{s}$=1.96 TeV using 171 pb-1 of data collected by the CDF II experiment at the Fermilab Tevatron Collider. The decay rates of these rare processes are sensitive to contributions from physics beyond the Standard Model. One event survives all our selection requirements,consistent with the background expectation. We derive branching ratio limits of BR(Bs->mu+mu-) mu+mu-) < 1.5 x 10^-7 at 90% confidence level.

  19. Acute toxicity and withdrawal syndromes related to γ-hydroxybutyrate (GHB) and its analogues γ-butyrolactone (GBL) and 1,4-butanediol (1,4-BD).

    Science.gov (United States)

    Wood, David M; Brailsford, Alan D; Dargan, Paul I

    2011-01-01

    Gamma-hydroxybutyrate (GHB) has been used as a recreational drug since the 1990s and over the last few years there has been increasing use of its analogues gamma-butyrolactone (GBL) and to a lesser extent 1,4-butanediol (1,4BD). This review will summarize the literature on the pharmacology of these compounds; the patterns and management of acute toxicity associated with their use; and the clinical patterns of presentation and management of chronic dependency associated with GHB and its analogues.

  20. Long-term stability of human genomic and human papillomavirus DNA stored in BD SurePath and Hologic PreservCyt liquid-based cytology media.

    Science.gov (United States)

    Agreda, Patricia M; Beitman, Gerard H; Gutierrez, Erin C; Harris, James M; Koch, Kristopher R; LaViers, William D; Leitch, Sharon V; Maus, Courtney E; McMillian, Ray A; Nussbaumer, William A; Palmer, Marcus L R; Porter, Michael J; Richart, Gregory A; Schwab, Ryan J; Vaughan, Laurence M

    2013-08-01

    We evaluated the effect of storage at 2 to 8°C on the stability of human genomic and human papillomavirus (HPV) DNA stored in BD SurePath and Hologic PreservCyt liquid-based cytology media. DNA retained the ability to be extracted and PCR amplified for more than 2.5 years in both medium types. Prior inability to detect DNA in archived specimens may have been due to failure of the extraction method to isolate DNA from fixed cells.

  1. Effect of cytochalasin B on 3-O-[(14)C]-methyl-D-glucose or D-[U-(14)C]glucose handling by BRIN-BD11 cells.

    Science.gov (United States)

    Cetik, Sibel; Rzajeva, Aigun; Malaisse, Willy J; Sener, Abdullah

    2014-07-01

    The present study aimed to investigate the effects of cytochalasin B (20 μM) on the uptake of 3-O-[(14)C]-methyl-D-glucose or D-[U-(14)C]glucose (8.3 mM each) by BRIN-BD11 cells. Taking into account the distribution space of tritiated water ((3)HOH), which was unexpectedly increased shortly after exposure of the cells to cytochalasin B and then progressively returned to its control values, and that of L-[1-(14)C]glucose, used as an extracellular marker, it was demonstrated that cytochalasin B caused a modest, but significant inhibition of the uptake of D-glucose and its non-metabolized analog by the BRIN-BD11 cells. These findings resemble those observed in acinar or ductal cells of the rat submaxillary gland and displayed a relative magnitude comparable to that found for the inhibition of D-glucose metabolism by cytochalasin B in purified pancreatic islet B cells. These findings reinforce the view that the primary site of action of cytochalasin B is located at the level of the plasma membrane.

  2. Development of a benthic diatom index of biotic integrity (BD-IBI) for ecosystem health assessment of human dominant subtropical rivers, China.

    Science.gov (United States)

    Tan, Xiang; Ma, Peiming; Bunn, Stuart E; Zhang, Quanfa

    2015-03-15

    As efforts intensify to address the issues of declining water quality and biodiversity losses in freshwater ecosystems, there have been great demands for effective methods of evaluating aquatic ecosystem health. In this study, benthic algae assemblages and water quality variables were analyzed to develop a benthic diatom-based index of biotic integrity (BD-IBI) for assessment of the aquatic environment in the upper Han River (China). Through the use of multivariate and multimetric approaches, four metrics - % prostrate individuals, % Amphora individuals, % polysaprob species, and diatom-based eutrophication/pollution index (EPI-D) - were identified from 98 candidate metrics to develop a BD-IBI. Application of the index revealed that water quality in 11% of the 31 sampled sites could be described as excellent condition, in 43% of the sites it could be described as good condition, in 25% as moderate condition, and in 21% as poor condition. The assessment further revealed that the main reason for degradation of the Han river ecosystem was nutrient enrichment through agricultural land use.

  3. Metabolic engineering of Pediococcus acidilactici BD16 for production of vanillin through ferulic acid catabolic pathway and process optimization using response surface methodology.

    Science.gov (United States)

    Kaur, Baljinder; Chakraborty, Debkumar; Kumar, Balvir

    2014-10-01

    Occurrence of feruloyl-CoA synthetase (fcs) and enoyl-CoA hydratase (ech) genes responsible for the bioconversion of ferulic acid to vanillin have been reported and characterized from Amycolatopsis sp., Streptomyces sp., and Pseudomonas sp. Attempts have been made to express these genes in Escherichia coli DH5α, E. coli JM109, and Pseudomonas fluorescens. However, none of the lactic acid bacteria strain having GRAS status was previously proposed for heterologous expression of fcs and ech genes for production of vanillin through biotechnological process. Present study reports heterologous expression of vanillin synthetic gene cassette bearing fcs and ech genes in a dairy isolate Pediococcus acidilactici BD16. After metabolic engineering, statistical optimization of process parameters that influence ferulic acid to vanillin biotransformation in the recombinant strain was carried out using central composite design of response surface methodology. After scale-up of the process, 3.14 mM vanillin was recovered from 1.08 mM ferulic acid per milligram of recombinant cell biomass within 20 min of biotransformation. From LCMS-ESI spectral analysis, a metabolic pathway of phenolic biotransformations was predicted in the recombinant P. acidilactici BD16 (fcs (+)/ech (+)).

  4. Substituting environmentally relevant flame retardants: assessment fundamentals. Vol. 1: results and summary overview; Erarbeitung von Bewertungsgrundlagen zur Substitution umweltrelevanter Flammschutzmittel. Bd. 1: Ergebnisse und zusammenfassende Uebersicht

    Energy Technology Data Exchange (ETDEWEB)

    Leisewitz, A.; Kruse, H.; Schramm, E.

    2001-04-01

    /Elektronik, Schienenfahrzeugbereich, Textil-/Polstermoebelindustrie. Parallel dazu werden dreizehn Flammschutzmittel hinsichtlich Mengenstrom, Anwendungen und Toxikologie/Oekotoxikologie charakterisiert. Bd. I: Ergebniszusammenfassung zu Flammschutzmitteleinsatz in Deutschland 1999/2000; Charakterisierung von 13 FSM nach Stoff- und Anwendungseigenschaften, Einsatzspektrum, Mengen; Ableitung von Bewertungsgrundlagen fuer FSM mit Schwergewicht auf Toxikologie/Oekotoxikologie, Kreislauffaehigkeit, Substitutions- und Minderungspotentialen; zusammenfassende Stoffbewertung zu 13 FSM; zusammenfassende Uebersicht zu FSM-Anwendungen. Bd. II: Anwendungsuntersuchungen (Stand der Technik, Trend, Alternativen) zu FSM bei UP-Harzen (Schienenfahrzeuge), bei PU-Daemm- und Montageschaeumen (Baubereich); bei Kunststoffen fuer E+E-Geraete insgesamt, Aussengehaeusen fuer E+E-Geraete und Leiterplatten (Elektro/Elektronikindustrie); bei Polstermoebeln/Matratzen (Textilanwendungen). Bd. III: Toxikologisch/oekotoxikologische Stoffprofile Decabromdiphenylether, Tetrabrombisphenol A; Bis[pentabromphenyl]ethan; Hexabromcyclododecan, Tris[chlorpropyl]phosphat, Resorcinol-bis-diphenyl-phosphat; N-Hydroxymethyl-3-dimethylphosphonpropionamid, roter Phosphor, Ammoniumpolyphosphat, Melamincyanurat, Aluminiumtrihydroxid, Borax, Antimontrioxid. (orig.)

  5. B-D试验监测失败原因分析%Analysis on causes of failure in B-D test monitoring

    Institute of Scientific and Technical Information of China (English)

    范立; 董翠玲

    2010-01-01

    @@ B-D 试验即布维-狄克试验(Bowie-Dicktest),目的是监测预真空或脉动真空压力蒸汽灭菌器内冷空气排出效果.依照相关规定要求,预真空或脉动真空压力蒸汽灭菌器每日使用前均需做B-D试验,在监测合格的基础上方可进行正式灭菌操作.为观察B-D试验实际意义,提高B-D试验的成功率,对本科2006-2008年连续3年B-D试验结果进行了统计分析,以改进B-D试验质量.

  6. Multicenter Evaluation of BD Max Enteric Parasite Real-Time PCR Assay for Detection of Giardia duodenalis, Cryptosporidium hominis, Cryptosporidium parvum, and Entamoeba histolytica

    Science.gov (United States)

    Relich, R. F.; Doyle, L.; Espina, N.; Fuller, D.; Karchmer, T.; Lainesse, A.; Mortensen, J. E.; Pancholi, P.; Veros, W.; Harrington, S. M.

    2016-01-01

    Common causes of chronic diarrhea among travelers worldwide include protozoan parasites. The majority of parasitic infections are caused by Giardia duodenalis, Entamoeba histolytica, Cryptosporidium parvum, and Cryptosporidium hominis. Similarly, these species cause the majority of parasitic diarrhea acquired in the United States. Detection of parasites by gold standard microscopic methods is time-consuming and requires considerable expertise; enzyme immunoassays and direct fluorescent-antibody (DFA) stains have lowered hands-on time for testing, but improvements in sensitivity and technical time may be possible with a PCR assay. We performed a clinical evaluation of a multiplex PCR panel, the enteric parasite panel (EPP), for the detection of these common parasites using the BD Max instrument, which performs automated extraction and amplification. A total of 2,495 compliant specimens were enrolled, including 2,104 (84%) specimens collected prospectively and 391 (16%) specimens collected retrospectively. Approximately equal numbers were received in 10% formalin (1,273 specimens) and unpreserved (1,222 specimens). The results from the EPP were compared to those from alternate PCR and bidirectional sequencing (APCR), as well as DFA (G. duodenalis and C. parvum or C. hominis) or trichrome stain (E. histolytica). The sensitivity and specificity for prospective and retrospective specimens combined were 98.2% and 99.5% for G. duodenalis, 95.5% and 99.6 for C. parvum or C. hominis, and 100% and 100% for E. histolytica, respectively. The performance of the FDA-approved BD Max EPP compared well to the reference methods and may be an appropriate substitute for microscopic examination or immunoassays. PMID:27535690

  7. Simultaneous determination of gamma-Hydroxybutyrate (GHB) and its analogues (GBL, 1.4-BD, GVL) in whole blood and urine by liquid chromatography coupled to tandem mass spectrometry

    DEFF Research Database (Denmark)

    Johansen, Sys Stybe; Windberg, Charlotte Norup

    2011-01-01

    A simple liquid chromatography-tandem mass spectrometry (LC-MS-MS) method has been developed and validated for simultaneous identification and quantification of ¿-hydroxybutyrate (GHB), ¿-butyrolactone (GBL), 1.4-butanediol (1.4-BD), and ¿-valerolactone (GVL) in whole blood from forensic cases...

  8. Gamma-Hydroxybutyrate (GHB), gamma-butyrolactone (GBL), and 1,4-butanediol (1,4-BD) reduce the volume of cerebral infarction in rodent transient middle cerebral artery occlusion.

    Science.gov (United States)

    Sadasivan, Shankar; Maher, Timothy J; Quang, Lawrence S

    2006-08-01

    gamma-Hydroxybutyric acid (GHB), an endogenous organic acid catabolite of gamma-aminobutyric acid (GABA), has been shown to have tissue-protective effects in various organs, including the brain. We examined the potential neuroprotective effect of GHB and its chemical precursors, gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD), in the rodent ischemic stroke model by intraluminal filament middle cerebral artery occlusion (MCAO). Adult male Sprague-Dawley rats underwent transient left-sided MCAO and received intraperitoneal treatment with 300 mg/kg of GHB, GBL, 1,4-BD, or control vehicle given at 30 min before, as well as 180 and 360 min after the onset of ischemia. Infarct volumes were determined 24 h after MCAO. In transient MCAO, the mean volume of infarction for control rats was 464.4 +/- 17.9 cu.mm versus 273.6 +/- 53.1, 233.3 +/- 44.7, and 275.4 +/- 39.9 cu.mm for rats treated with 1,4-BD (P GBL (P GBL, and 1,4-BD protect against rat focal cerebral ischemia from transient MCAO.

  9. Strategy for rapid identification and antibiotic susceptibility testing of gram-negative bacteria directly recovered from positive blood cultures using the Bruker MALDI Biotyper and the BD Phoenix system.

    Science.gov (United States)

    Wimmer, Jana L; Long, S Wesley; Cernoch, Patricia; Land, Geoffrey A; Davis, James R; Musser, James M; Olsen, Randall J

    2012-07-01

    Decreasing the time to species identification and antibiotic susceptibility determination of strains recovered from patients with bacteremia significantly decreases morbidity and mortality. Herein, we validated a method to identify Gram-negative bacteria directly from positive blood culture medium using the Bruker MALDI Biotyper and to rapidly perform susceptibility testing using the BD Phoenix.

  10. Validation of a Multiplex Real-Time PCR Assay for Detection of Mycobacterium spp., Mycobacterium tuberculosis Complex, and Mycobacterium avium Complex Directly from Clinical Samples by Use of the BD Max Open System.

    Science.gov (United States)

    Rocchetti, Talita T; Silbert, Suzane; Gostnell, Alicia; Kubasek, Carly; Widen, Raymond

    2016-06-01

    A multiplex real-time PCR was validated on the BD Max open system to detect different Mycobacterium tuberculosis complex, Mycobacterium avium complex, and Mycobacterium spp. directly from clinical samples. The PCR results were compared to those with traditional cultures. The multiplex PCR assay was found to be a specific and sensitive method for the rapid detection of mycobacteria directly from clinical specimens.

  11. Educating Juveniles with Disabilities in Correctional Settings. Fifth CCBD Mini-Library Series: Meeting the Diverse Needs of Children and Youth with E/BD--Evidence-Based Programs and Practices.

    Science.gov (United States)

    Gagnon, Joseph Calvin; Mayer, Matthew J.

    This monograph addresses issues in the appropriate education of children and youth with disabilities, especially emotional and/or behavioral disorders, who are in juvenile correctional facilities. An introductory chapter considers the characteristics of students with E/BD in the public schools; educational services in juvenile corrections; and…

  12. The innate defense antimicrobial peptides hBD3 and RNase7 are induced in human umbilical vein endothelial cells by classical inflammatory cytokines but not Th17 cytokines.

    Science.gov (United States)

    Burgey, Christine; Kern, Winfried V; Römer, Winfried; Sakinc, Türkan; Rieg, Siegbert

    2015-05-01

    Antimicrobial peptides are multifunctional effector molecules of innate immunity. In this study we investigated whether endothelial cells actively contribute to innate defense mechanisms by expression of antimicrobial peptides. We therefore stimulated human umbilical vein endothelial cells (HUVEC) with inflammatory cytokines, Th17 cytokines, heat-inactivated bacteria, bacterial conditioned medium (BCM) of Staphylococcus aureus and Streptococcus sanguinis, and lipoteichoic acid (LTA). Stimulation with single cytokines induced discrete expression of human β-defensin 3 (hBD3) by IFN-γ or IL-1β and of ribonuclease 7 (RNase7) by TNF-α without any effects on LL-37 gene expression. Stronger hBD3 and RNase7 induction was observed after combined stimulation with IL-1β, TNF-α and IFN-γ and was confirmed by high hBD3 and RNase7 peptide levels in cell culture supernatants. In contrast, Th17 cytokines or stimulation with LTA did not result in AMP production. Moreover, only BCM of an invasive S. aureus bacteremia isolate induced hBD3 in HUVEC. We conclude that endothelial cells actively contribute to prevent dissemination of pathogens at the blood-tissue-barrier by production of AMPs that exhibit microbicidal and immunomodulatory functions. Further investigations should focus on tissue-specific AMP induction in different endothelial cell types, on pathogen-specific induction patterns and potentially involved pattern-recognition receptors of endothelial cells.

  13. Tracking Advanced Planetary Systems (TAPAS) with HARPS-N. III. HD 5583 and BD+15 2375 - two cool giants with warm companions

    Science.gov (United States)

    Niedzielski, A.; Villaver, E.; Nowak, G.; Adamów, M.; Kowalik, K.; Wolszczan, A.; Deka-Szymankiewicz, B.; Adamczyk, M.; Maciejewski, G.

    2016-04-01

    Context. Evolved stars are crucial pieces for our understanding of the dependency of the planet formation mechanism on the stellar mass and for exploring the mechanism involved in star-planet interactions more deeply. Over the last ten years, we have monitored about 1000 evolved stars for radial velocity variations in the search for low-mass companions under the Penn State - Torun Centre for Astronomy Planet Search program with the Hobby-Eberly Telescope (HET). Selected prospective candidates that required higher RV precision measurements were followed with HARPS-N at the 3.6 m Telescopio Nazionale Galileo under the TAPAS project. Aims: We aim to detect planetary systems around evolved stars to be able to build sound statistics on the frequency and intrinsic nature of these systems, and to deliver in-depth studies of selected planetary systems with evidence of star-planet interaction processes. Methods: For HD 5583 we obtained 14 epochs of precise RV measurements that were collected over 2313 days with the HET, and 22 epochs of ultra-precise HARPS-N data collected over 976 days. For BD+15 2375 we collected 24 epochs of HET data over 3286 days and 25 epochs of HARPS-S data over 902 days. Results: We report the discovery of two planetary mass objects that are orbiting two evolved red giant stars: HD 5583 has a msini = 5.78MJ companion at 0.529 AU in a nearly circular orbit (e = 0.076), the closest companion to a giant star detected with the RV technique, and BD+15 2735 that, with a msini = 1.06MJ, holds the record for the lightest planet orbiting an evolved star found so far (in a circular e = 0.001, 0.576 AU orbit). These are the third and fourth planets found within the TAPAS project, a HARPS-N monitoring of evolved planetary systems identified with the HET. Based on observations obtained with the Hobby-Eberly Telescope, which is a joint project of the University of Texas at Austin, the Pennsylvania State University, Stanford University, Ludwig

  14. Hairy root induction and phytoremediation of textile dye, Reactive green 19A-HE4BD, in a halophyte, Sesuvium portulacastrum (L. L.

    Directory of Open Access Journals (Sweden)

    Vinayak H. Lokhande

    2015-12-01

    Full Text Available In this study, we report phytoremediation of textile dyes using hairy roots derived through Agrobacterium rhizogenes (NCIM 5140 infection of in vitro leaf and stem explants of a halophyte Sesuvium portulacastrum (L. L. Leaf explants showed higher frequency of hairy root induction (70% than stem explants (30%, and maximum number of roots (leaf 42.3 ± 2.4 and stem 50.3 ± 1.7. Transformed nature of hairy roots was ascertained by amplifying 970 bp region of T-DNA of Ri plasmid. Hairy roots were screened for phytoremediation of various textile dyes and results showed that HRs were able to degrade Reactive green 19A HE4BD upto 98% within 5 days of incubation. Spectrophotometric analysis showed decrease in dye concentration while HPLC and FTIR analysis confirmed its degradation. Seed germination assay demonstrated non-toxic nature of the extracted metabolites. This is the first report on induction of hairy root culture in Sesuvium portulacastrum and phytoremediation of textile dyes.

  15. The Design and Production of the LHCb VELO High Voltage System and Analysis of the Bd ⇒ K*μ+μ- Rare Decay

    CERN Document Server

    Rakotomiaramanana, Barinjaka Mamitiana; Soler, P

    2010-01-01

    LHCb is the dedicated flavour physics experiment of the LHC. The experiment is designed for probing new physics through measurements of CP violation and rare decays. This thesis includes simulation studies of the Bd ⇒ K*μ+μ- decay. The LHCb vertex locator (VELO) is the highest precision tracking detector at the LHC and is used to identify primary and secondary vertices for the identification of the $b$ and $c$ hadrons. The VELO modules contain silicon strip detectors which must be operated under reverse bias voltage. This thesis presents the work performed on the design, production and characterisation of the VELO high voltage system. The VELO operates only 8\\mm~from the LHC beam in a high radiation environment. A future upgrade will require operation at up to 10$^{16}$ n_{eq}cm^{-2}.This thesis presents a characterisation of p-type silicon sensors before and after heavy irradiations. The design of the HV system and the substantial programme of quality assurance tests performed on both the hardware and so...

  16. Search for $B_s \\rightarrow \\mu^{+}\\mu^{-}$ and $B_d \\rightarrow \\mu^{+}\\mu^{-}$ decays with the full CDF Run II data set

    CERN Document Server

    Aaltonen, T; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Apollinari, G; Appel, J A; Arisawa, T; Artikov, A; Asaadi, J; Ashmanskas, W; Auerbach, B; Aurisano, A; Azfar, F; Badgett, W; Bae, T; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Barria, P; Bartos, P; Bauce, M; Bedeschi, F; Behari, S; Bellettini, G; Bellinger, J; Benjamin, D; Beretvas, A; Bhatti, A; Bland, K R; Blumenfeld, B; Bocci, A; Bodek, A; Bortoletto, D; Boudreau, J; Boveia, A; Brigliadori, L; Bromberg, C; Brucken, E; Budagov, J; Budd, H S; Burkett, K; Busetto, G; Bussey, P; Butti, P; Buzatu, A; Calamba, A; Camarda, S; Campanelli, M; Canelli, F; Carls, B; Carlsmith, D; Carosi, R; Carrillo, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavaliere, V; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chokheli, D; Cho, K; Ciocci, M A; Clark, A; Clarke, C; Convery, M E; Conway, J; Corbo, M; Cordelli, M; Cox, C A; Cox, D J; Cremonesi, M; Cruz, D; Cuevas, J; Culbertson, R; d'Ascenzo, N; Datta, M; de Barbaro, P; Demortier, L; Deninno, M; d'Errico, M; Devoto, F; Di Canto, A; Di Ruzza, B; Dittmann, J R; Donati, S; D'Onofrio, M; Dorigo, M; Driutti, A; Ebina, K; Edgar, R; Elagin, A; Erbacher, R; Errede, S; Esham, B; Eusebi, R; Farrington, S; Fernandez Ramos, J P; Field, R; Flanagan, G; Forrest, R; Franklin, M; Freeman, J C; Frisch, H; Funakoshi, Y; Garfinkel, A F; Garosi, P; Gerberich, H; Gerchtein, E; Giagu, S; Giakoumopoulou, V; Gibson, K; Ginsburg, C M; Giokaris, N; Giromini, P; Giurgiu, G; Glagolev, V; Glenzinski, D; Goldin, D; Gold, M; Golossanov, A; Gomez-Ceballos, G; Gomez, G; Goncharov, M; Gonzalez Lopez, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gramellini, E; Grinstein, S; Grosso-Pilcher, C; Group, R C; Guimaraes da Costa, J; Hahn, S R; Han, J Y; Happacher, F; Hara, K; Hare, M; Harrington-Taber, T; Harr, R F; Hatakeyama, K; Hays, C; Heinrich, J; Herndon, M; Hocker, A; Hong, Z; Hopkins, W; Hou, S; Hughes, R E; Husemann, U; Huston, J; Introzzi, G; Iori, M; Ivanov, A; James, E; Jang, D; Jayatilaka, B; Jeon, E J; Jindariani, S; Jones, M; Joo, K K; Junk, T R; Jun, S Y; Kambeitz, M; Kamon, T; Karchin, P E; Kasmi, A; Kato, Y; Ketchum, W; Keung, J; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kimura, N; Kim, Y J; Kim, Y K; Kirby, M; Knoepfel, K; Kondo, K; Kong, D J; Konigsberg, J; Kotwal, A V; Kreps, M; Kroll, J; Kruse, M; Kuhr, T; Kurata, M; Laasanen, A T; Lammel, S; Lancaster, M; Lannon, K; Latino, G; Lee, H S; Lee, J S; Leone, S; Leo, S; Lewis, J D; Limosani, A; Lipeles, E; Liu, H; Liu, Q; Liu, T; Lockwitz, S; Loginov, A; Lucchesi, D; Lueck, J; Lujan, P; Lukens, P; Lungu, G; Lysak, R; Lys, J; Madrak, R; Maestro, P; Malik, S; Manca, G; Manousakis-Katsikakis, A; Margaroli, F; Marino, P; Martinez, M; Matera, K; Mattson, M E; Mazzacane, A; Mazzanti, P; McNulty, R; Mehta, A; Mehtala, P; Mesropian, C; Miao, T; Mietlicki, D; Mitra, A; Miyake, H; Moed, S; Moggi, N; Moon, C S; Moore, R; Morello, M J; Mukherjee, A; Muller, Th; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Naganoma, J; Nakano, I; Napier, A; Nett, J; Neu, C; Nigmanov, T; Nodulman, L; Noh, S Y; Norniella, O; Oakes, L; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Orava, R; Ortolan, L; Pagliarone, C; Palencia, E; Palni, P; Papadimitriou, V; Parker, W; Pauletta, G; Paulini, M; Paus, C; Phillips, T J; Piacentino, G; Pianori, E; Pilot, J; Pitts, K; Plager, C; Pondrom, L; Poprocki, S; Potamianos, K; Pranko, A; Prokoshin, F; Ptohos, F; Punzi, G; Ranjan, N; Redondo Fernandez, I; Renton, P; Rescigno, M; Riddick, T; Rimondi, F; Ristori, L; Robson, A; Rodriguez, T; Rolli, S; Ronzani, M; Roser, R; Rosner, J L; Ruffini, F; Ruiz, A; Russ, J; Rusu, V; Safonov, A; Sakumoto, W K; Sakurai, Y; Santi, L; Sato, K; Saveliev, V; Savoy-Navarro, A; Schlabach, P; Schmidt, E E; Schwarz, T; Scodellaro, L; Scuri, F; Seidel, S; Seiya, Y; Semenov, A; Sforza, F; Shalhout, S Z; Shears, T; Shepard, P F; Shimojima, M; Shochet, M; Shreyber-Tecker, I; Simonenko, A; Sinervo, P; Sliwa, K; Smith, J R; Snider, F D; Song, H; Sorin, V; Sperka, D; Stancari, M; St. Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Sudo, Y; Sukhanov, A; Suslov, I; Takemasa, K; Takeuchi, Y; Tang, J; Tecchio, M; Teng, P K; Thom, J; Thomson, E; Thukral, V; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Totaro, P; Trovato, M; Ukegawa, F; Uozumi, S; Vazquez, F; Velev, G; Vellidis, C; Vernieri, C; Vidal, M; Vilar, R; Vizan, J; Vogel, M; Volpi, G; Wagner, P; Wallny, R; Wang, S M; Warburton, A; Waters, D; Wester, W C, III; Whiteson, D; Wicklund, A B; Wilbur, S; Williams, H H; Wilson, J S; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, H; Wright, T; Wu, X; Wu, Z; Yamamoto, K; Yamato, D; Yang, T; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yi, K; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Zanetti, A M; Zeng, Y; Zhou, C; Zucchelli, S

    2013-01-01

    We report on a search for \\bsmm\\ and \\bdmm\\ decays using proton-antiproton collision data at $\\sqrt{s}=1.96$~TeV corresponding to $10~\\fb$ of integrated luminosity collected by the CDF detector at the Fermilab Tevatron collider. The observed number of \\bd\\ candidates is consistent with background-only expectations and yields an upper limit on the branching fraction of $\\brbdmm < 4.6\\times 10^{-9}$ at 95\\% confidence level. We observe an excess of \\bs\\ candidates. The probability that the background processes alone could produce such an excess or larger is $0.94\\%$. The probability that the combination of background and the expected standard model rate of \\bsmm\\ could produce such an excess or larger is $6.8\\%$. These data are used to determine a branching fraction $\\brbsmm = (1.3^{+0.9}_{-0.7}) \\times 10^{-8} $ and provide an upper limit of $\\brbsmm < 3.1\\times 10^{-8}$ at 95\\% confidence level.

  17. SU(3) and CP violating weak and strong final state phases for B_{d}^{0} and B_{s}^{0} decays

    CERN Document Server

    Fayyazuddin, A

    2006-01-01

    Using rotation in SU(3) space, a set of relations between various decay modes of B_{d}^{0} and B_{s}^{0} are derived. In particular the decays bar{B}_{d}^{0}->rho ^{+}K^{-}, bar{B}_{s}^{0}-> K^{*^{+}}K^{-} and bar{B}_{d}^{0}-> K^{*^{-}}pi ^{+}, bar{B}_{s}^{0}-> K^{*^{-}}K^{+} are expressed in terms of the decay parameters of bar{B}_{d}^{0}->rho ^{+}pi ^{-},rho ^{-}\\pi ^{+}. From the experimental data, we derive the bounds: 0.12leq r_{-,+}leq 0.28; 0.15\\leq r_{+,-}\\leq 0.38. Further in the range -0.18\\leq z_{-+,+-}leq -0.28 it is possible to get a solution delta _{-,+}=delta_{+,-}=pi -delta ^{prime} for 62^{o} geq delta ^{prime}geq 35^{o} and 53^{o}leq gamma leq 71^{o} However, for 0.25leq z_{+-}leq 0.45 and -0.45\\leq z_{-+}leq -0.25, we get a complementry solution delta_{-+}=pi -delta _{+-}; 50^{o}geq delta_{+-} geq 35^{o} ; 50^{o}leq gamma leq 71^{o}. Assuming factorization for electroweak penguin, we obtain the sum rule f_{rho }-(1/3)f_{omega}-(2/3)f_{phi}=0 which is well satisfied experimentally.

  18. Sigma-1 Receptor Antagonist BD1047 Reduces Mechanical Allodynia in a Rat Model of Bone Cancer Pain through the Inhibition of Spinal NR1 Phosphorylation and Microglia Activation.

    Science.gov (United States)

    Zhu, Shanshan; Wang, Chenchen; Han, Yuan; Song, Chao; Hu, Xueming; Liu, Yannan

    2015-01-01

    Previous studies have demonstrated that sigma-1 receptor plays important roles in the induction phase of rodent neuropathic pain; however, whether it is involved in bone cancer pain (BCP) and the underlying mechanisms remain elusive. The aim of this study was to examine the potential role of the spinal sigma-1 receptor in the development of bone cancer pain. Walker 256 mammary gland carcinoma cells were implanted into the intramedullary space of the right tibia of Sprague-Dawley rats to induce ongoing bone cancer-related pain behaviors; our findings indicated that, on days 7, 10, 14, and 21 after operation, the expression of sigma-1 receptor in the spinal cord was higher in BCP rats compared to the sham rats. Furthermore, intrathecal injection of 120 nmol of sigma-1 receptor antagonist BD1047 on days 5, 6, and 7 after operation attenuated mechanical allodynia as well as the associated induction of c-Fos and activation of microglial cells, NR1, and the subsequent Ca(2+)-dependent signals of BCP rats. These results suggest that sigma-1 receptor is involved in the development of bone cancer pain and that targeting sigma-1 receptor may be a new strategy for the treatment of bone cancer pain.

  19. Purification of soybean major allergen Gly m Bd 28K and preparation of its polyclonal antibodies%大豆主要过敏原GlymBd28K的分离纯化及多抗血清的制备

    Institute of Scientific and Technical Information of China (English)

    席俊; 高学梅; 闫慧丽; 陆启玉

    2015-01-01

    The 28K(Gly m Bd 28K)was isolated and purified from defatted soybean flour. Then it was used to prepare the rabbit polyclonal antisera. 28K protein was extracted with an alkali solution and acid formulation. 28K crude protein was attended by ammonium sulfate precipitation method, and then DEAE–Sepharose CL–6B further purified 28K,28K was detected purity by SDS–PAGE electrophoresis,prepared the rabbit polyclonal antiserum,tested antisera titer by indirect ELISA. In the study,28K was successfully purified,the titer of rabbit antisera obtained was up to 1∶51200,and rabbit antisera were prepared. That might provide a basis for the study on major allergens of soybean protein 28K monoclonal antibody and 28K IgG determine.%该文从脱脂大豆粉中分离纯化28K(Gly m Bd 28K)蛋白,并制备多抗血清。方法用碱溶酸提法提取28K蛋白,盐析法制得28K粗蛋白,DEAE–Sepharose CL–6B层析纯化28K蛋白, SDS–聚丙烯酰胺凝胶电泳检测蛋白的纯度,制备兔抗血清,用间接ELISA法检测效价。该实验纯化出28K蛋白,制备了抗28K的多抗血清,效价为1∶51200。为研究大豆主要过敏原蛋白28K的单克隆抗体制备及28K的IgG结合表位的确定奠定了基础。

  20. Synergistic anti-inflammatory activity of the antimicrobial peptides human beta-defensin-3 (hBD-3 and cathelicidin (LL-37 in a three-dimensional co-culture model of gingival epithelial cells and fibroblasts.

    Directory of Open Access Journals (Sweden)

    Telma Blanca Lombardo Bedran

    Full Text Available Given the spread of antibiotic resistance in bacterial pathogens, antimicrobial peptides that can also modulate the immune response may be a novel approach for effectively controlling periodontal infections. In the present study, we used a three-dimensional (3D co-culture model of gingival epithelial cells and fibroblasts stimulated with Aggregatibacter actinomycetemcomitans lipopolysaccharide (LPS to investigate the anti-inflammatory properties of human beta-defensin-3 (hBD-3 and cathelicidin (LL-37 and to determine whether these antimicrobial peptides can act in synergy. The 3D co-culture model composed of gingival fibroblasts embedded in a collagen matrix overlaid with gingival epithelial cells had a synergistic effect with respect to the secretion of IL-6 and IL-8 in response to LPS stimulation compared to fibroblasts and epithelial cells alone. The 3D co-culture model was stimulated with non-cytotoxic concentrations of hBD-3 (10 and 20 µM and LL-37 (0.1 and 0.2 µM individually and in combination in the presence of A. actinomycetemcomitans LPS. A multiplex ELISA assay was used to quantify the secretion of 41 different cytokines. hBD-3 and LL-37 acted in synergy to reduce the secretion of GRO-alpha, G-CSF, IP-10, IL-6, and MCP-1, but only had an additive effect on reducing the secretion of IL-8 in response to A. actinomycetemcomitans LPS stimulation. The present study showed that hBD-3 acted in synergy with LL-37 to reduce the secretion of cytokines by an LPS-stimulated 3D model of gingival mucosa. This combination of antimicrobial peptides thus shows promising potential as an adjunctive therapy for treating inflammatory periodontitis.

  1. Recoding of the stop codon UGA to glycine by a BD1-5/SN-2 bacterium and niche partitioning between Alpha- and Gammaproteobacteria in a tidal sediment microbial community naturally selected in a laboratory chemostat

    Energy Technology Data Exchange (ETDEWEB)

    Hanke, Anna [Max Planck Institute for Marine Microbiology; Hamann, Emmo [Max Planck Institute for Marine Microbiology; Sharma, Ritin [ORNL; Geelhoed, Jeanine [Max Planck Institute for Marine Microbiology; Hargesheimer, Theresa [Max Planck Institute for Marine Microbiology; Kraft, Beate [Max Planck Institute for Marine Microbiology; Meyer, Volker [Max Planck Institute for Marine Microbiology; Lenk, Sabine [Max Planck Institute for Marine Microbiology; Osmers, Harald [Max Planck Institute for Marine Microbiology; Wu, Rong [Delft University of Technology, Delft, Netherlands; Makinwa, Kofi [Delft University of Technology, Delft, Netherlands; Hettich, Robert {Bob} L [ORNL; Banfield, Jillian F. [University of California, Berkeley; Tegetmeyer, Halina [Max Planck Institute for Marine Microbiology; Strouss, Marc [University of Calgary, ALberta, Canada

    2014-01-01

    Sandy coastal sediments are global hot spots for microbial mineralization of organic matter and denitrification. These sediments are characterized by advective pore water flow, tidal cycling and an active and complex microbial community. Metagenomic sequencing of microbial communities sampled from such sediments showed that potential sulfuroxidizing Gammaproteobacteria and members of the enigmaticBD1-5/ SN-2 candidatephylumwereabundantinsitu (>10% and 2% respectively). By mimicking the dynamic oxic/anoxic environmental conditions of the sedimentin a laboratory chemostat, a simplified microbial community was selected from the more complex inoculum. Metagenomics, proteomics and fluorescenceinsituhybridization showed that this simplified community contained both a potential sulfuroxidizing Gamma proteobacteria (at 24 2% abundance) and a member of the BD1-5 / SN-2candidatephylum (at 7 6%abundance). Despite the abundant supply of organic substrates to the chemostat, proteomic analysis suggested that the selected gamma proteobacterium grew partially auto trophically and performed hydrogen/formate oxidation. The enrichment of a member of the BD1-5/SN-2candidatephylum enabled, for the first time, direct microscopic observation by fluorescent insitu hybridization and the experimental validation of the previously predicted translation of the stop codon UGA into glycine.

  2. Benchmarking Compound Methods (CBS-QB3, CBS-APNO, G3, G4, W1BD) against the Active Thermochemical Tables: Formation Enthalpies of Radicals.

    Science.gov (United States)

    Somers, Kieran P; Simmie, John M

    2015-08-20

    The 298.15 K formation enthalpies of 38 radicals with molecular formula CxHyOz have been computed via the atomization procedure using the five title methods. The computed formation enthalpies are then benchmarked against the values recommended in the Active Thermochemical Tables (ATcT). The accuracy of the methods have been interpreted in terms of descriptive statistics, including the mean-signed error, mean-unsigned error, maximum average deviation, 2σ uncertainties, and 2×root-mean-square-deviations (2RMSD). The results highlight the following rank order of accuracy for the methods studied G4 > G3 > W1BD > CBS-APNO > CBS-QB3. The findings of this work are also considered in light of a recent companion study, which took an identical approach to quantifying the accuracies of these methods for 48 closed-shell singlet CxHyOz compounds. A similar order of accuracies and precisions were observed therein: G3 > G4 > W1BD > CBS-APNO > CBS-QB3. Both studies highlight systematic biases/deviations from the ATcT for the methods investigated, which are discussed in some detail, with methods having clear tendencies to over- or underpredict the recommended formation enthalpies for radical and/or closed-shell CxHyOz compounds. We show that one can improve the accuracy of their computation, and simultaneously reduce the uncertainty, by taking unweighted average formation enthalpies from various combinations of methods used. The reader should note that the statistical analyses preceding these conclusions also highlight that these error cancellation effects are unique for closed-shell and radical species. By extension, these error-cancellation effects can be expected to be different for various homologous series and chemical functionalities and their closed- and open-shell subgroups. Hence, further benchmarking studies are advised for other homologous series, such that the scientists and engineers (e.g., combustion/atmospheric/astrochemical) who frequently use these methods can

  3. Affinity composite cryogel discs functionalized with Reactive Red 120 and Green HE 4BD dye ligands: Application on the separation of human immunoglobulin G subclasses

    Energy Technology Data Exchange (ETDEWEB)

    Huseynli, Sabina; Baydemir, Gözde; Sarı, Esma [Department of Chemistry, Biochemistry Division, Hacettepe University, Ankara (Turkey); Elkak, Assem [Laboraory of “Valorisation des Ressources Naturelles et Produits de Santé (VRNPS)”, Doctoral School of Sciences and Technology, Lebanese University, Rafic Hariri University Campus, Hadath (Lebanon); Denizli, Adil, E-mail: denizli@hacettepe.edu.tr [Department of Chemistry, Biochemistry Division, Hacettepe University, Ankara (Turkey)

    2015-01-01

    Naturally produced by the human immune system, immunoglobulin nowadays is widely used for in vivo and in vitro purposes. The increased needs for pure immunoglobulin have prompted researchers to find new immunoglobulin chromatographic separation processes. Cryogels as chromatographic adsorbents, congregate several mechanical features including good compatibility, large pore structure, flexibility, short diffusion pathway and stability. These different characteristics make them a good alternative to conventional chromatographic methods and allowing their potential use in separation technology. In the present study, two sets of poly(2-hydroxyethyl methacrylate) (PHEMA) based beads were prepared and functionalized with Reactive Red 120 (RR) and Reactive Green HE 4BD (RG) dyes, and then embedded into supermacroporous cryogels. The morphology, physical and chemical features of the prepared bead embedded composite cryogel discs (CCDs) were performed by scanning electron microscopy (SEM), swelling test, elemental analysis and Fourier transform infrared spectroscopy (FTIR). The results showed that the embedded composite cryogel discs have a specific surface area of 192.0 m{sup 2}/g with maximum adsorption capacity of HIgG 239.8 mg/g for the RR functionalized CCD and 170 mg/g for RG functionalized CCD columns, both at pH 6.2. - Highlights: • Dye attached composite cryogel discs were prepared to separate HIgG subclasses. • Composite cryogels characterized by swelling, FTIR, SEM and elemental analysis. • Reactive Green HE 4B and Reactive Red 120 dyes were used as the affinity ligand. • HIgG and subclasses were separate from both aqueous solution and human plasma.

  4. Multicenter evaluation of the BD max enteric bacterial panel PCR assay for rapid detection of Salmonella spp., Shigella spp., Campylobacter spp. (C. jejuni and C. coli), and Shiga toxin 1 and 2 genes.

    Science.gov (United States)

    Harrington, S M; Buchan, B W; Doern, C; Fader, R; Ferraro, M J; Pillai, D R; Rychert, J; Doyle, L; Lainesse, A; Karchmer, T; Mortensen, J E

    2015-05-01

    Diarrhea due to enteric bacterial pathogens causes significant morbidity and mortality in the United States and worldwide. However, bacterial pathogens may be infrequently identified. Currently, culture and enzyme immunoassays (EIAs) are the primary methods used by clinical laboratories to detect enteric bacterial pathogens. We conducted a multicenter evaluation of the BD Max enteric bacterial panel (EBP) PCR assay in comparison to culture for the detection of Salmonella spp., Shigella spp., Campylobacter jejuni, and Campylobacter coli and an EIA for Shiga toxins 1 and 2. A total of 4,242 preserved or unpreserved stool specimens, including 3,457 specimens collected prospectively and 785 frozen, retrospective samples, were evaluated. Compared to culture or EIA, the positive percent agreement (PPA) and negative percent agreement (NPA) values for the BD Max EBP assay for all specimens combined were as follows: 97.1% and 99.2% for Salmonella spp., 99.1% and 99.7% for Shigella spp., 97.2% and 98.4% for C. jejuni and C. coli, and 97.4% and 99.3% for Shiga toxins, respectively. Discrepant results for prospective samples were resolved with alternate PCR assays and bidirectional sequencing of amplicons. Following discrepant analysis, PPA and NPA values were as follows: 97.3% and 99.8% for Salmonella spp., 99.2% and 100% for Shigella spp., 97.5% and 99.0% for C. jejuni and C. coli, and 100% and 99.7% for Shiga toxins, respectively. No differences in detection were observed for samples preserved in Cary-Blair medium and unpreserved samples. In this large, multicenter study, the BD Max EBP assay showed superior sensitivity compared to conventional methods and excellent specificity for the detection of enteric bacterial pathogens in stool specimens.

  5. A BD/SINS Integrated Navigation Algorithm and a Clock Error Handling Method%BD/SINS紧组合导航及时钟误差处理算法

    Institute of Scientific and Technical Information of China (English)

    王龙; 王楠; 鲁浩

    2015-01-01

    The navigation accuracy of the pure SINS system can not satisfy the high performance requirement of air-to-air missile when the cruise range of the missile is too long .The GNSS/SINS integrated navigation is an effective method to solve this problem .Because of the successful application of the Beidou satellites navigation system,the research on BD/SINS integrated navigation has become a hot engineering field .In this paper,the integrated navigation algorithm of the BD/SINS is studied .The gain-restriction Kalman filter is adopted in the fusion of the information from the SINS and the BD receiver .In order to mitigate the inverse effect of the clock error of the receiver,a special method is used to eliminate the clock error .Simulation result proved that the integrated navigation method has a high navigation accuracy .%远距空空导弹飞行时间长,纯惯性导航难以满足高精度要求,而卫星定位/捷联惯性组合导航是解决此难题的一种有效方式,因此,采用基于伪距/伪距率的北斗/捷联惯性组合导航算法,该导航算法使用限定增益Kalman滤波器,对接收机钟差做了特殊处理,使得滤波结果不受钟差影响。仿真表明,该北斗/捷联惯性组合导航算法有较高的导航精度。

  6. Research on BD BACTEC 9120 blood culture instrument combined with serum PCT in diagnosis of bloodstream infections%BD BACTEC 9120血培养仪联合血清降钙素原在血流感染诊断中的应用

    Institute of Scientific and Technical Information of China (English)

    郭盼; 马萍; 王海龙; 董彬; 尚晓泓

    2015-01-01

    目的:比较革兰阳性(G+)菌和革兰阴性(G-)菌血流感染(BSI)的血清降钙素原(PCT)水平,探讨血培养与PCT联合检测在临床诊断中的意义。方法:采用BD BACTEC9120型全自动血培养仪对199例住院发热患者的血液标本进行细菌培养,同时检测PCT水平,比较PCT浓度水平在血培养阳性与阴性之间以及革兰阳性细菌与阴性细菌之间的差异。结果:①筛选出检测PCT的99例血培养阳性标本中分别检出18种细菌,其中表皮葡萄球菌构成比最大(占17.2%);其余依次为大肠埃希菌(占16.2%)和鲍曼不动杆菌(占10.1%);②血培养阳性与血培养阴性标本PCT结果比较差异有统计学意义;③血培养革兰阳性菌与革兰阴性菌PCT结果比较无明显差异,但如果将革兰阳性菌组金黄色葡萄球菌的结果去除,再与革兰阴性菌相比差异有统计学意义。结论:PCT对革兰阴性菌与革兰阳性菌感染有一定的判别作用,配合血培养检测能辅助临床的快速诊断,提示临床初步抗生素的使用方向,减少用药的盲目性和耐药菌株的出现。%Objective: Compare gram-positive (G+)bacteria and gram-negative bacteria (G-) bloodstream infections of serum procalcitonin(PCT) original level, to explore the clinical significance of blood culture and PCT joint detection. Methods: One hundred and ninty nine cases were selected, by using BD BACTEC 9120 type automatic blood culture instrument to detect the bacterial culture and at the same time the PCT results, comparative PCT concentration in blood cultures between positive and negative results and gram-positive bacteria and gram-negative bacteria. Results:(1)Screening detection of PCT were detected in 99 cases of specimens of blood culture positive for 18 species of bacteria including staphylococcus epidermis form than most, by 17.2%;The second is the e. coli were 16.2%and 10.1%acinetobacter baumannii. (2)blood culture positive for

  7. Determination of γ-hydroxybutyrate (GHB), β-hydroxybutyrate (BHB), pregabalin, 1,4-butane-diol (1,4BD) and γ-butyrolactone (GBL) in whole blood and urine samples by UPLC-MSMS.

    Science.gov (United States)

    Dahl, Sandra Rinne; Olsen, Kirsten Midtbøen; Strand, Dag Helge

    2012-02-15

    The demand of high throughput methods for the determination of gamma-hydroxybutyrate (GHB) and its precursors gamma-butyrolactone (GBL) and 1,4-butane-diol (1,4BD) as well as for pregabalin is increasing. Here we present two analytical methods using ultra-high pressure liquid chromatography (UPLC) and tandem mass spectrometric (MS/MS) detection for the determination of GHB, beta-hydroxybutyrate (BHB), pregabalin, 1,4BD and GBL in whole blood and urine. Using the 96-well formate, the whole blood method is a simple high-throughput method suitable for screening of large sample amounts. With an easy sample preparation for urine including only dilution and filtration of the sample, the method is suitable for fast screening of urine samples. Both methods showed acceptable linearity, acceptable limits of detection, and limits of quantification. The within-day and between-day precisions of all analytes were lower than 10% RSD. The analytes were extracted from matrices with recoveries near 100%, and no major matrix effects were observed. Both methods have been used as routine screening analyses of whole blood and urine samples since January 2010.

  8. Performance of the BD MAX™ instrument with Check-Direct CPE real-time PCR for the detection of carbapenemase genes from rectal swabs, in a setting with endemic dissemination of carbapenemase-producing Enterobacteriaceae.

    Science.gov (United States)

    Antonelli, Alberto; Arena, Fabio; Giani, Tommaso; Colavecchio, Olga Lorenza; Valeva, Stoyanka Valentinova; Paule, Suzanne; Boleij, Peter; Rossolini, Gian Maria

    2016-09-01

    Carbapenemase-producing Enterobacteriaceae (CPE) represent an increasing public health issue and the early detection of colonization by CPE can help the implementation of infection control measures among inpatients. In this study, BD MAX Check-Direct CPE screen, with two different Master Mixes (BDMix and CPMix), using the automatic BD MAX(™) instrument, was evaluated for the detection of blaKPC, blaOXA-48, blaVIM and blaNDM genes, in comparison to selective broth enrichment and direct culture from rectal swabs. Among a total of 557 rectal swabs samples, 29 (5.2%) tested positive for CPE (23 for blaKPC, 5 for blaVIM and one for blaOXA-48). The sensitivity, specificity, positive and negative likelihood ratios values were 93.1%, 97.3%, 34.5 and 0.07, for BMix, and 100%, 97.1 %, 34.5 and 0 for CPMix, respectively. Five samples were positive with molecular methods only. The turn-around time was reduced from 18-24 hours (direct culture), or 48 h (broth enrichment) to only 3 h.

  9. Isolation of RNA from residual BD SurePath liquid-based cytology specimens and detection of HPV E6/E7 mRNA using the PreTectt HPV-Proofer assay.

    Science.gov (United States)

    Dixon, Eric P; King, Lorraine M; Adams, Melissa D; Grønn, Petter; Murphy, Patricia G; Brown, Charlotte A; Brough, George H; Skomedal, Hanne; Malinowski, Douglas P; Fischer, Timothy J

    2008-12-01

    Infection with high-risk human papillomavirus (HPV) is known to be associated directly with the development of cervical cancer. Recent data suggests that the detection of E6/E7 mRNA from high-risk HPV types may serve as a better diagnostic method for detecting the presence of cervical pre-cancer than HPV DNA testing. This report details a commercially available nucleic acid isolation protocol which can be used to isolate reproducibly RNA from residual BD SurePath liquid-based cytology specimens stored for up to 28 days, and have demonstrated the quality and quantity of mRNA is sufficient for detection with the NorChip PreTect HPV-Proofer assay. Of the 242 specimens tested in this study, 236 (97.5%) tested positive for U1A internal control gene expression. HPV type 16, 18, 31, 33 or 45 mRNA was detected in 16/20 (80%) of the analyzed high-grade squamous intraepithelial lesion (HSIL) specimens, with a low frequency of HPV mRNA detected in the normal lesions (3%). The presence of HPV E6 expression in a subset of HPV positive specimens was also detected by real-time RT-PCR. These findings confirm that RNA of sufficient quality can be isolated from residual BD SurePath cervical cytology specimens for use in downstream NASBA and RT-PCR-based assays.

  10. Cloning and sequence analysis of Wadi sheep defensin sBD-1 gene and establishment and application of SYBR green Ⅰ real-time fluorescence quantitative PCR method%洼地绵羊防御素sBD-1基因克隆、序列分析及SYBR Green Ⅰ实时荧光定量检测方法的建立与应用

    Institute of Scientific and Technical Information of China (English)

    王金良; 郭显坡; 沈志强; 李敏; 任艳玲

    2011-01-01

    根据GenBank上登录的绵羊防御素基因序列,经多重比较后,设计1对引物,从洼地绵羊舌上皮组织中扩增到防御素sBD-1基因,克隆到pMD18-T载体中进行测序.结果表明,扩增基因全长215 bp,编码64个氨基酸.基因进化树分析表明,与蒙古绵羊sBD-1基因有较近的亲缘关系,核苷酸同源性为98.5%;而与黄牛的亲缘关系最远,核苷酸同源性84.6%.氨基酸序列分析表明,序列内无信号肽区域,具有3个潜在的抗原表位.以pMD18-T/sBD-1质粒为模板建立了sBD-1基因SYBR Green Ⅰ荧光定量PCR检测方法,核酸电泳、扩增动力学曲线、溶解曲线及重复性试验表明,检测方法具有良好的稳定性和特异性,得到的回归方程(R2=0.998)表明PCR产物量的对数值与起始模板量之间存在良好的线性关系,从舌、盲肠及输卵管等组织中可以进行有效的检测,检测灵敏度为83.9 copies/μL.该方法为进一步研究防御素sBD-1基因在洼地绵羊抗逆性过程中的作用奠定了基础.%According to the published gene sequences of defensin gene of sheep on GenBank,one pair of primers were designed and defensin Sbd-1 gene was amplified by RT-PCR from tongue epithelial tissue of Wadi sheep. PCR product was cloned into the Pmd18-T vector and sequenced. The results showed that gene amplication of full-length was 215 bp, encoding 64 amino acids. Phylogenetic tree analysis showed that Wadi sheep and Menggu sheep had close phylogenetic relationship,nucleotide homology was 98. 5%;kinship with the Bos taurus as far as the nucleotide ho-mology of 84. 6%. Amino acid sequence analysis showed no signal peptide amino acid sequence in the region, with three potential antigenic epitopes. Sbd-1 gene SYBR Green I fluorescence quantitative PCR method was set up u-sing Pmd18-T/Sbd-l plasmid as a template. Nucleic acid electrophoresis,amplification kinetics,dissolution curve and repeatability tests showed that the methods had good stability and

  11. Substituting environmentally relevant flame retardants: assessment fundamentals. Vol. 3: toxicological and ecotoxicological substance profiles of selected flame retardants; Erarbeitung von Bewertungsgrundlagen zur Substitution umweltrelevanter Flammschutzmittel. Bd. 3: Toxikologisch-oekotoxikologische Stoffprofile ausgewaehlter Flammschutzmittel

    Energy Technology Data Exchange (ETDEWEB)

    Leisewitz, A.; Kruse, H.; Paulsen, O.; Schau, C.; Wieben, M.; Boehde, U.

    2001-04-01

    /Elektronik, Schienenfahrzeugbereich, Textil-/Polstermoebelindustrie. Parallel dazu werden dreizehn Flammschutzmittel hinsichtlich Mengenstrom, Anwendungen und Toxikologie/Oekotoxikologie charakterisiert. Bd. I: Ergebniszusammenfassung zu Flammschutzmitteleinsatz in Deutschland 1999/2000; Charakterisierung von 13 FSM nach Stoff- und Anwendungseigenschaften, Einsatzspektrum, Mengen; Ableitung von Bewertungsgrundlagen fuer FSM mit Schwergewicht auf Toxikologie/Oekotoxikologie, Kreislauffaehigkeit, Substitutions- und Minderungspotentialen; zusammenfassende Stoffbewertung zu 13 FSM; zusammenfassende Uebersicht zu FSM-Anwendungen. Bd. II: Anwendungsuntersuchungen (Stand der Technik, Trend, Alternativen) zu FSM bei UP-Harzen (Schienenfahrzeuge), bei PU-Daemm- und Montageschaeumen (Baubereich); bei Kunststoffen fuer E+E-Geraete insgesamt, Aussengehaeusen fuer E+E-Geraete und Leiterplatten (Elektro/Elektronikindustrie); bei Polstermoebeln/Matratzen (Textilanwendungen). Bd. III: Toxikologisch/oekotoxikologische Stoffprofile Decabromdiphenylether, Tetrabrombisphenol A; Bis[pentabromphenyl]ethan; Hexabromcyclododecan, Tris[chlorpropyl]phosphat, Resorcinol-bis-diphenyl-phosphat; N-Hydroxymethyl-3-dimethylphosphonpropionamid, roter Phosphor, Ammoniumpolyphosphat, Melamincyanurat, Aluminiumtrihydroxid, Borax, Antimontrioxid. (orig.)

  12. Benchmarking Compound Methods (CBS-QB3, CBS-APNO, G3, G4, W1BD) against the Active Thermochemical Tables: A Litmus Test for Cost-Effective Molecular Formation Enthalpies.

    Science.gov (United States)

    Simmie, John M; Somers, Kieran P

    2015-07-16

    The theoretical atomization energies of some 45 CxHyOz molecules present in the Active Thermochemical Tables compilation and of particular interest to the combustion chemistry community have been computed using five composite model chemistries as titled. The species contain between 1-8 "heavy" atoms, and a few are conformationally diverse with up to nine conformers. The enthalpies of formation at 0 and 298.15 K are then derived via the atomization method and compared against the recommended values. In general, there is very good agreement between our averaged computed values and those in the ATcT; those for 1,3-cyclopentadiene exceptionally differ considerably, and we show from isodesmic reactions that the true value for 1,3-cyclopentadiene is closer to 134 kJ mol(-1) than the reported 101 kJ mol(-1). If one is restricted to using a single method, statistical measures indicate that the best methods are in the rank order G3 ≈ G4 > W1BD > CBS-APNO > CBS-QB3. The CBS-x methods do on average predict ΔfH(⊖)(298.15 K) within ≈5 kJ mol(-1) but are prone to occasional lapses. There are statistical advantages to be gained from using a number of methods in tandem, and all possible combinations have been tested. We find that the average formation enthalpy coming from using CBS-APNO/G4, CBS-APNO/G3, and G3/G4 show lower mean signed and mean unsigned errors, and lower standard and root-mean-squared deviations, than any of these methods in isolation. Combining these methods also leads to the added benefit of providing an uncertainty rooted in the chemical species under investigation. In general, CBS-APNO and W1BD tend to underestimate the formation enthalpies of target species, whereas CBS-QB3, G3, and G4 have a tendency to overestimate the same. Thus, combining CBS-APNO with a G3/G4 combination leads to an improvement in all statistical measures of accuracy and precision, predicting the ATcT values to within 0.14 ± 4.21 kJ mol(-1), thus rivalling "chemical accuracy" (

  13. 艰难梭菌毒素A/B、BD-PCR毒素基因及GDH检测对艰难梭菌相关性腹泻的诊断价值%Detection of Clostridium Botulinum Toxin A/B, BD-PCR Toxin Gene and GDH in the Diagnosis of Clostridium Botulinum Associated Diarrhea

    Institute of Scientific and Technical Information of China (English)

    邵婧; 丁宸; 徐萍萍

    2016-01-01

    目的 探讨艰难梭菌毒素A/B及其相关毒素基因检测对艰难梭菌相关性腹泻的诊断价值.方法 收集2015年1月至2015年10月我院ICU病房腹泻疑似艰难梭菌感染患者的粪便标本133例作为研究对象,分别采用艰难梭菌培养法、CDAB法、PCR毒素基因检测法及艰难梭菌毒素GDH检测法进行检测,以艰难梭菌培养法结果为金标准,计算各方法的诊断指标所包含有的特异度、敏感度、阴性预测值和阳性预测值等.结果 本研究收集的133例粪便标本中,经过金标准粪便样本厌氧培养法检出阳性结果20例,阴性结果113例.CDAB法具有低敏感度(0.550)和高特异度(0.912),诊断符合率为0.932,BD-PCR毒素基因检测法具有高敏感度(0.950)和高特异度(0.929),诊断符合率为0.932,艰难梭菌毒素GDH检测法的高敏感度(0.900)和低特异度(0.779),诊断符合率为0.797.结论 对于疑似艰难梭菌感染,可联合艰难梭菌GDH、艰难梭菌毒素A/B(CDAB)或进行荧光定量PCR毒素基因共同检测,有效降低检测时间,为临床医师及时提供准确的诊断依据,并制定行之有效的治疗措施.

  14. The discovery of a new infrared emission feature at 1905 wavenumbers (5.25 microns) in the spectrum of BD + 30 deg 3639 and its relation to the polycyclic aromatic hydrocarbon model

    Science.gov (United States)

    Allamandola, L. J.; Bregman, J. D.; Sandford, S. A.; Tielens, A. G. G. M.; Witteborn, F. C.

    1989-01-01

    A new IR emission feature at 1905/cm (5.25 microns) has been discovered in the spectrum of BD + 30 deg 3639. This feature joins the family of well-known IR emission features at 3040, 2940, 1750, 1610, '1310', 1160, and 890/cm. The origin of this new feature is discussed and it is assigned to an overtone or combination band involving C-H bending modes of polycyclic aromatic hydrocarbons (PAHs). Laboratory work suggests that spectral studies of the 2000-1650/cm region may be very useful in elucidating the molecular structure of interstellar PAHs. The new feature, in conjunction with other recently discovered spectral structures, suggests that the narrow IR emission features originate in PAH molecules rather than large carbon grains.

  15. LOOKING FOR A CONNECTION BETWEEN THE Am PHENOMENON AND HYBRID {delta} Sct -{gamma} Dor PULSATION: DETERMINATION OF THE FUNDAMENTAL PARAMETERS AND ABUNDANCES OF HD 114839 AND BD +18 4914

    Energy Technology Data Exchange (ETDEWEB)

    Hareter, M.; Weiss, W. [Department of Astronomy, University of Vienna, Tuerkenschanzstrasse 17, A-1180 Wien (Austria); Fossati, L. [Department of Physics and Astronomy, Open University, Walton Hall, Milton Keynes MK6 7AA (United Kingdom); Suarez, J. C. [Instituto de Astrofisica de Andalucia (CSIC), Glorieta de la Astronomia S/N, 18008, Granada (Spain); Uytterhoeven, K. [Kiepenheuer-Institut fuer Sonnenphysik, Schoeneckstr. 6, D-79104 Freiburg (Germany); Rainer, M.; Poretti, E., E-mail: hareter@astro.univie.ac.at [INAF-Osservatorio Astronomico di Brera, Via E. Bianchi 46, 23807, Merate (Saint Lucia) (Italy)

    2011-12-20

    {delta} Sct-{gamma} Dor hybrids pulsate simultaneously in p- and g-modes, which carry information on the structure of the envelope as well as to the core. Hence, they are key objects for investigating A and F type stars with asteroseismic techniques. An important requirement for seismic modeling is small errors in temperature, gravity, and chemical composition. Furthermore, we want to investigate the existence of an abundance indicator typical for hybrids, something that is well established for the roAp stars. Previous to the present investigation, the abundance pattern of only one hybrid and another hybrid candidate has been published. We obtained high-resolution spectra of HD 114839 and BD +18 4914 using the SOPHIE spectrograph of the Observatoire de Haute-Provence and the HARPS spectrograph at ESO La Silla. For each star we determined fundamental parameters and photospheric abundances of 16 chemical elements by comparing synthetic spectra with the observations. We compare our results to that of seven {delta} Sct and nine {gamma} Dor stars. For the evolved BD +18 4914 we found an abundance pattern typical for an Am star, but could not confirm this peculiarity for the less evolved star HD 114839, which is classified in the literature as uncertain Am star. Our result supports the concept of evolved Am stars being unstable. With our investigation we nearly doubled the number of spectroscopically analyzed {delta} Sct-{gamma} Dor hybrid stars, but did not yet succeed in identifying a spectroscopic signature for this group of pulsating stars. A statistically significant spectroscopic investigation of {delta} Sct- {gamma} Dor hybrid stars is still missing, but would be rewarding considering the asteroseismological potential of this group.

  16. Gamma hydroxybutyrate (GHB), gamma butyrolactone (GBL) and 1,4-butanediol (1,4-BD; BDO): A literature review with a focus on UK fatalities related to non-medical use.

    Science.gov (United States)

    Corkery, John M; Loi, Barbara; Claridge, Hugh; Goodair, Christine; Corazza, Ornella; Elliott, Simon; Schifano, Fabrizio

    2015-06-01

    Misuse of gamma hydroxybutrate (GHB) and gamma butyrolactone (GBL) has increased greatly since the early 1990s, being implicated in a rising number of deaths. This paper reviews knowledge on GHB and derivatives, and explores the largest series of deaths associated with their non-medical use. Descriptive analyses of cases associated with GHB/GBL and 1,4-butanediol (1,4-BD) use extracted from the UK's National Programme on Substance Abuse Deaths database. From 1995 to September 2013, 159 GHB/GBL-associated fatalities were reported. Typical victims: White (92%); young (mean age 32 years); male (82%); with a drug misuse history (70%). Most deaths (79%) were accidental or related to drug use, the remainder (potential) suicides. GHB/GBL alone was implicated in 37%; alcohol 14%; other drugs 28%; other drugs and alcohol 15%. Its endogenous nature and rapid elimination limit toxicological detection. Post-mortem blood levels: mean 482 (range 0-6500; SD 758)mg/L. Results suggest significant caution is needed when ingesting GHB/GBL, particularly with alcohol, benzodiazepines, opiates, stimulants, and ketamine. More awareness is needed about risks associated with consumption.

  17. Simultaneous determination of γ-Hydroxybutyrate (GHB) and its analogues (GBL, 1.4-BD, GVL) in whole blood and urine by liquid chromatography coupled to tandem mass spectrometry.

    Science.gov (United States)

    Johansen, Sys Stybe; Windberg, Charlotte Norup

    2011-01-01

    A simple liquid chromatography-tandem mass spectrometry (LC-MS-MS) method has been developed and validated for simultaneous identification and quantification of γ-hydroxybutyrate (GHB), γ-butyrolactone (GBL), 1.4-butanediol (1.4-BD), and γ-valerolactone (GVL) in whole blood from forensic cases. The sample preparation of whole blood involved protein precipitation by acidic methanol. Urine samples were diluted and evaluated in relation to a control at the cutoff concentration. Hexadeutero GHB (GHB-d(6)) was used as the internal standard. Separation was achieved by reversed-phase chromatography, and detection was by MS-MS in MRM mode. The linear range for all compounds was from 1.0 to 100 mg/kg in whole blood with a limit of quantification of about 1 mg/kg. The method was validated with regards to selectivity, recovery, accuracy and precision, and stability. The method is currently applied to investigations on suspected drug-facilitated sexual assaults, driving under the influence of drugs, and general intoxication with these substances.

  18. Brief introduction of the systematic treatment enhancement program for bipolar disorder%双相障碍系统治疗的增强计划(STEP-BD)简介

    Institute of Scientific and Technical Information of China (English)

    叶尘宇

    2009-01-01

    @@ 双相障碍系统治疗的增强计划(systematic treatment enhancement program for bipolar disorder,STEP-BD)是由美国国立精神卫生研究所出资进行的研究(REP98-DS-0001),以探讨治疗双相障碍有效的共同的干预模式.该研究从1999年正式启动,历时6年之久,由哈佛医学院、马萨诸塞洲医院的Sachs教授总负责.目前根据所收集的资料已发表了70余篇相关的研究文献,并且仍有资料在分析中.在此,本文对于STEP-BP的研究背景、研究目的、研究设计和主要研究结果作一简述.

  19. Plutarque, Sur l' E de Delphes 390 B 6-8 et l'explication de  la vision en Timée 45 b-d*

    Directory of Open Access Journals (Sweden)

    Alain Lernould

    2005-04-01

    Full Text Available Le traité (ou dialogue « pythique » du platonicien Plutarque de Chéronée (Iier – IIe s. ap. J.-C. intitulé Sur l’E de Delphes est consacré à l’élucidation de la signification de l’E (la cinquième lettre de l’alphabet grec consacré à Apollon Pythien. Une des interprétations (d’inspiration pythagoricienne est que cet E désigne le nombre cinq, le nombre de l’univers. Dans le cadre de l’exposé de cette interprétation est fait état de l’opinion « de certains » selon laquelle il existe une correspondance entre les cinq sens et les cinq éléments. L’A. montre que les deux lignes où il est question de la vue (E 390b6-8 s’inspirent essentiellement de l’explication qu’en Timée 45b-d Platon donne du mécanisme de la vision en termes de mélange du feu pur émis par l’œil avec le feu pur extérieur qui produit la lumière du jour. L’extrême brièveté de ce résumé (empreint d’aristotélisme, l’élément associé à la vue étant ici l’éther considéré comme cinquième corps, d’un passage dans Platon offrant lui-même bon nombre de difficultés, explique que ces deux lignes énigmatiques n’aient jamais été bien comprises. Au passage, l’A. revient sur les notions d’homoiopatheia (d’homogénéité et de summetria (de commensurabilité en Timée 45b-d et 67c-e pour en proposer une interprétation qui souligne et éclaire d’un jour nouveau le caractère dynamique de l’explication platonicienne de la vision. Un Appendice donne un aperçu des différentes lectures d’E 390b6-8 depuis les premières éditions imprimées à la Renaissance jusqu’aux éditions critiques des 19e et 20e siècles.The essay (or dialogue On the E at Delphi of the Platonist Plutarch of Chaeronea (c. 50 – c. 125 A.D. is devoted to the elucidation of the mysterious E – the fifth letter of the Greek alphabet – that is dedicated to Apollo. According to one interpretation the E is, in a Pythagorean

  20. The discovery of a new infrared emission feature at 1905 wavenumbers (5.25 microns) in the spectrum of BD +30 degrees 3639 and its relation to the polycyclic aromatic hydrocarbon model

    Science.gov (United States)

    Allamandola, L. J.; Bregman, J. D.; Sandford, S. A.; Tielens, A. G.; Witteborn, F. C.; Wooden, D. H.; Rank, D.

    1989-01-01

    We have discovered a new IR emission feature at 1905 cm-1 (5.25 microns) in the spectrum of BD +30 degrees 3639. This feature joins the family of well-known IR emission features at 3040, 2940, 1750, 1610, "1310," 1160, and 890 cm-1 (3.3, 3.4, 5.7, 6.2, "7.7," 8.6, and 11.2 microns). The origin of this new feature is discussed and it is assigned to an overtone or combination band involving C-H bending modes of polycyclic aromatic hydrocarbons (PAHs). Laboratory work suggests that spectral studies of the 2000-1650 cm-1 (5.0-6.1 microns) region may be very useful in elucidating the molecular structure of interstellar PAHs. The new feature, in conjunction with other recently discovered spectral structure, suggests that the narrow IR emission features originate in PAH molecules rather than large carbon grains. Larger species are likely to be the source of the broad underlying "plateaus" seen in many of the spectra.

  1. Direct inoculation method using BacT/ALERT 3D and BD Phoenix System allows rapid and accurate identification and susceptibility testing for both Gram-positive cocci and Gram-negative rods in aerobic blood cultures.

    Science.gov (United States)

    Yonetani, Shota; Okazaki, Mitsuhiro; Araki, Koji; Makino, Hiroshi; Fukugawa, Yoko; Okuyama, Takahiro; Ohnishi, Hiroaki; Watanabe, Takashi

    2012-06-01

    This study describes a direct inoculation method using the automated BacT/ALERT 3D and the BD Phoenix System in combination for identification and susceptibility testing of isolates from positive blood cultures. Organism identification and susceptibility results were compared with the conventional method for 211 positive aerobic blood cultures. Of 110 Gram-positive cocci (GPCs), 98 (89.1%) isolates were correctly identified to the species level. Of 101 Gram-negative rods (GNRs), 98 (97.0%) isolates were correctly identified to the species level. The overall categorical agreement in antimicrobial susceptibility testing among the 110 GPCs was 92.7%, with 0.04% very major and 0.7% major error rates. The overall categorical agreement among 78 isolates of enterobacteria and 23 isolates of nonfermenters in GNRs was 99.5% and 91.1%, respectively, with no major errors identified. We conclude that, compared with previously reported direct inoculation methods, our method is superior in identification and susceptibility testing of GPCs.

  2. Performance assessment of a nested-PCR assay (the RAPID BAP-MTB) and the BD ProbeTec ET system for detection of Mycobacterium tuberculosis in clinical specimens.

    Science.gov (United States)

    Wang, Jann-Yuan; Lee, Li-Na; Chou, Chin-Sheng; Huang, Chung-Yi; Wang, Shu-Kuan; Lai, Hsin-Chih; Hsueh, Po-Ren; Luh, Kwen-Tay

    2004-10-01

    The performance of a nested PCR-based assay (the RAPID BAP-MTB; AsiaGen, Taichung, Taiwan) and the BD ProbeTec ET (DTB) system (Becton Dickinson, Sparks, Md.) for detection of Mycobacterium tuberculosis was evaluated with 600 consecutive clinical samples. These samples, including 552 respiratory specimens and 48 nonrespiratory specimens, were collected from 333 patients treated at National Taiwan University Hospital from September to October 2003. The results of both assays were compared to the gold standard of combined culture results and clinical diagnosis. The overall sensitivity and specificity of the RAPID BAP-MTB assay for respiratory specimens were 66.7% and 97.2%, respectively, and for the DTB assay they were 56.7% and 95.3%, respectively. The positive and negative predictive values for the RAPID BAP-MTB were 74.1% and 96.0%, respectively, and for the DTB assay they were 59.6% and 94.7%, respectively. For smear-negative samples, the sensitivity of the RAPID BAP-MTB and DTB assays was 57.1% and 40.5%, respectively. The RAPID BAP-MTB assay produced 14 false-positive results in 14 samples, including one of the six samples yielding Mycobacterium abscessus, one of the six samples yielding Mycobacterium avium intracellulare, one sample from a patient with a history of pulmonary tuberculosis with complete treatment, and three samples from three patients with a previous diagnosis of tuberculosis who were under treatment at the time of specimen collection. Among the 48 nonrespiratory specimens, the RAPID BAP-MTB assay was positive in one biopsy sample from a patient with lumbar tuberculous spondylitis and one pus sample from a patient with tuberculous cervical lymphadenopathy. Our results showed that the RAPID BAP-MTB assay is better than the DTB assay for both respiratory specimens and nonrespiratory specimens. The overall time for processing this assay is only 5 h. In addition, its diagnostic accuracy in smear-negative samples is as high as in smear

  3. Prompt detection of influenza A and B viruses using the BD Veritor™ System Flu A+B, Quidel® Sofia® Influenza A+B FIA, and Alere BinaxNOW® Influenza A&B compared to real-time reverse transcription-polymerase chain reaction (RT-PCR).

    Science.gov (United States)

    Dunn, Jim; Obuekwe, Joy; Baun, Traci; Rogers, Justin; Patel, Twinkle; Snow, Linda

    2014-05-01

    The performance characteristics of rapid influenza diagnostic tests vary widely. This study evaluated the BD Veritor™ System Flu A+B (Veritor; BD Diagnostics, Sparks, MD, USA), Quidel® Sofia® Influenza A+B FIA (Sofia; Quidel Corp., San Diego, CA, USA), and Alere BinaxNOW® Influenza A&B (Binax; Alere Scarborough, Inc., Scarborough, ME, USA) compared to reverse transcription-polymerase chain reaction (RT-PCR) for detection of influenza viruses in nasal wash specimens from 240 pediatric patients. Positive percent agreements for influenza A and B virus detection were 93.8% and 94.2%, 95.8% and 98.1%, and 79.2% and 80.8% for Veritor, Sofia, and Binax, respectively. The Veritor and Binax tests demonstrated negative percent agreements >97.9% for detection of both influenza viruses, but the negative percent agreement of the Sofia test was 91.1% for influenza A and 70.7% for influenza B virus. Overall, the Veritor and Sofia tests were nearly as sensitive as RT-PCR and considerably more sensitive than Binax for detection of influenza viruses. However, the accuracy of the Sofia test was significantly lower than either Veritor or Binax.

  4. To BD or not to BD: functional neuroimaging and the boundaries of bipolarity.

    Science.gov (United States)

    Kuiper, Sandy; McLean, Loyola; Malhi, Gin S

    2013-01-01

    Bipolar disorders are major mood disorders defined by the presence of discrete episodes of depression and either mania, in bipolar I disorder, or hypomania, in bipolar II disorder. There is little contention that both are serious psychiatric conditions or that they are associated with substantial suffering, disability, risk of suicide and cost to the community. Recently, focus has shifted away from classic manic-depressive illness toward a 'bipolar spectrum' model, which allows for much softer presentations to be conceptualized as bipolarity, but the boundaries of this concept remain contentious. In this article, we will consider the contribution of neuroimaging to delineating the bipolar phenotype and differentiating it from similar disorders.

  5. Substituting environmentally relevant flame retardants: assessment fundamentals. Vol. 2: flame-retardant finishings of selected products - applications-focused analysis: state of the art, trends, alternatives; Erarbeitung von Bewertungsgrundlagen zur Substitution umweltrelevanter Flammschutzmittel. Bd. 2: Flammhemmende Ausruestung ausgewaehlter Produkte - anwendungsbezogene Betrachtung: Stand der Technik, Trend, Alternativen

    Energy Technology Data Exchange (ETDEWEB)

    Leisewitz, A.; Schwarz, W.

    2001-04-01

    /Elektronik, Schienenfahrzeugbereich, Textil-/Polstermoebelindustrie. Parallel dazu werden dreizehn Flammschutzmittel hinsichtlich Mengenstrom, Anwendungen und Toxikologie/Oekotoxikologie charakterisiert. Bd. I: Ergebniszusammenfassung zu Flammschutzmitteleinsatz in Deutschland 1999/2000; Charakterisierung von 13 FSM nach Stoff- und Anwendungseigenschaften, Einsatzspektrum, Mengen; Ableitung von Bewertungsgrundlagen fuer FSM mit Schwergewicht auf Toxikologie/Oekotoxikologie, Kreislauffaehigkeit, Substitutions- und Minderungspotentialen; zusammenfassende Stoffbewertung zu 13 FSM; zusammenfassende Uebersicht zu FSM-Anwendungen. Bd. II: Anwendungsuntersuchungen (Stand der Technik, Trend, Alternativen) zu FSM bei UP-Harzen (Schienenfahrzeuge), bei PU-Daemm- und Montageschaeumen (Baubereich); bei Kunststoffen fuer E+E-Geraete insgesamt, Aussengehaeusen fuer E+E-Geraete und Leiterplatten (Elektro/Elektronikindustrie); bei Polstermoebeln/Matratzen (Textilanwendungen). Bd. III: Toxikologisch/oekotoxikologische Stoffprofile Decabromdiphenylether, Tetrabrombisphenol A; Bis[pentabromphenyl]ethan; Hexabromcyclododecan, Tris[chlorpropyl]phosphat, Resorcinol-bis-diphenyl-phosphat; N-Hydroxymethyl-3-dimethylphosphonpropionamid, roter Phosphor, Ammoniumpolyphosphat, Melamincyanurat, Aluminiumtrihydroxid, Borax, Antimontrioxid. (orig.)

  6. Interaction between cAMP, volume‑regulated anion channels and the Na+‑HCO3‑‑cotransporter, NBCe1, in the regulation of nutrient‑ and hypotonicity‑induced insulin release from isolated rat pancreatic islets and tumoral insulin‑producing BRIN‑BD11 cells.

    Science.gov (United States)

    Bulur, Nurdan; Crutzen, Raphael; Malaisse, Willy J; Sener, Abdullah; Beauwens, Renaud; Golstein, Philippe

    2013-05-01

    Soluble adenylyl cyclase (sAC) has been hypothesized to play a role in insulin secretion. The present study aimed to investigate the interaction between adenosine 3',5'‑cyclic monophosphate (cAMP), volume‑regulated anion channels (VRACs) and the electrogenic sodium bicarbonate (Na+‑HCO3‑) cotransporter, NBCe1, in the regulation of nutrient‑ and hypotonicity‑induced insulin release from rat pancreatic islets and tumoral insulin‑producing BRIN‑BD11 cells. In the islets, 5‑nitro‑2‑(3‑phenylpropylamino)benzoic acid (NPPB) and 5‑chloro‑2‑hydroxy‑3‑(thiophene‑2‑carbonyl)indole‑1‑carboxamide (tenidap) reduced glucose‑stimulated insulin release, however, only NPPB suppressed the enhancing action of cAMP analogs upon such a release. Insulin output from the BRIN‑BD11 cells was stimulated by 2‑ketoisocaproate (KIC) or extracellular hypoosmolarity. cAMP analogs and 3‑isobutyl‑1‑methylxanthine increased the insulin output recorded in the isotonic medium to a greater relative extent than that in the hypotonic medium. The secretory response to KIC or hypotonicity was inhibited by NPPB or tenidap, which both also opposed the enhancing action of cAMP analogs. Inhibitors of mitogen‑activated protein (MAP) kinase decreased insulin output in isotonic and hypotonic media. The inhibitor of sAC, 2‑hydroxyestriol, caused only a modest inhibition of insulin release, whether in the isotonic or hypotonic medium, even when tested at a concentration of 100 µM. The omission of NaHCO3 markedly decreased the secretory response to KIC or extracellular hypotonicity. The omission of Na+ suppressed the secretory response to extracellular hypotonicity. The observations of the present study do not support the hypothesis of a major role for sAC in the regulation of insulin release.

  7. Etude de la mesure du paramètre alpha dans le cadre de la violation de la symétrie CP à l'aide du canal $B_{d}^{0} \\to \\pi^{+} \\pi^{-}\\pi^{0}$ dans l'expérience LHCb

    CERN Document Server

    Robert, Arnaud

    2005-01-01

    L'analyse temporelle du correlogramme de Dalitz du canal a trois corps Bd en pi+ pi- pi0 conduit a l'extraction de l'un des parametres definissant la violation de la symetrie CP dans le Modele Standard Electrofaible, l'angle alpha, exempte d'ambiguites discretes entre 0 et pi. Elle permet, entre autres, d'acceder independamment aux valeurs des principaux parametres QCD regissant la desintegration. La contrepartie experimentale repose cependant sur une statistique de signal suffisamment pure et importante et une maitrise precise de la phenomenologie associee. Combines a un rapport d'embranchement de l'ordre de 2.10^{-5}, ces deux arguments justifient a eux seuls le caractere non trivial d'une telle analyse dans l'environnement hadronique de l'experience dediee LHCb. A partir de la reponse simulee du detecteur, et en particulier des performances du calorimetre electromagnetique, cette these montre l'interet essentiel de la reconstruction specifique des pions neutres tres energiques et la necessite d'introduire ...

  8. Measurement of Bd mixing using opposite-side flavor tagging

    CERN Document Server

    Abazov, V M; Abolins, M; Acharya, B S; Adams, M; Adams, T; Agelou, M; Aguiló, E; Ahn, S H; Ahsan, M; Alexeev, G D; Alkhazov, G; Alton, A; Alverson, G; Alves, G A; Anastasoaie, M; Andeen, T; Anderson, S; Andrieu, B; Anzelc, M S; Arnoud, Y; Arov, M; Askew, A; Åsman, B; Assis-Jesus, A C S; Atramentov, O; Autermann, C; Avila, C; Ay, C; Badaud, F; Baden, A; Bagby, L; Baldin, B; Bandurin, D V; Banerjee, P; Banerjee, S; Barberis, E; Bargassa, P; Baringer, P; Barnes, C; Barreto, J; Bartlett, J F; Bassler, U; Bauer, D; Beale, S; Bean, A; Begalli, M; Begel, M; Belanger-Champagne, C; Bellantoni, L; Bellavance, A; Benítez, J A; Beri, S B; Bernardi, G; Bernhard, R; Berntzon, L; Bertram, I; Besançon, M; Beuselinck, R; Bezzubov, V A; Bhat, P C; Bhatnagar, V; Binder, M; Biscarat, C; Black, K M; Blackler, I; Blazey, G; Blekman, F; Blessing, S; Bloch, D; Bloom, K; Blumenschein, U; Böhnlein, A; Boeriu, O; Bolton, T A; Borissov, G; Bos, K; Bose, T; Brandt, A; Brock, R; Brooijmans, G; Bross, A; Brown, D; Buchanan, N J; Buchholz, D; Bühler, M; Büscher, V; Burdin, S; Burke, S; Burnett, T H; Busato, E; Buszello, C P; Butler, J M; Calfayan, P; Calvet, S; Cammin, J; Caron, S; Carvalho, W; Casey, B C K; Cason, N M; Castilla-Valdez, H; Chakrabarti, S; Chakraborty, D; Chan, K M; Chandra, A; Charles, F; Cheu, E; Chevallier, F; Cho, D K; Choi, S; Choudhary, B; Christofek, L; Claes, D; Clement, B; Clément, C; Coadou, Y; Cooke, M; Cooper, W E; Coppage, D; Corcoran, M; Cousinou, M C; Cox, B; Crepe-Renaudin, S; Cutts, D; Cwiok, M; Da Motta, H; Das, A; Das, M; Davies, B; Davies, G; Davis, G A; De, K; de Jong, P; De Jong, S J; De La Cruz-Burelo, E; De Oliveira Martins, C; Degenhardt, J D; Déliot, F; Demarteau, M; Demina, R; Demine, P; Denisov, D; Denisov, S P; Desai, S; Diehl, H T; Diesburg, M; Doidge, M; Dominguez, A; Dong, H; Dudko, L V; Duflot, L; Dugad, S R; Duggan, D; Duperrin, A; Dyer, J; Dyshkant, A; Eads, M; Edmunds, D; Edwards, T; Ellison, J; Elmsheuser, J; Elvira, V D; Eno, S; Ermolov, P; Evans, H; Evdokimov, A; Evdokimov, V N; Fatakia, S N; Feligioni, L; Ferapontov, A V; Ferbel, T; Fiedler, F; Filthaut, F; Fisher, W; Fisk, H E; Fleck, I; Ford, M; Fortner, M; Fox, H; Fu, S; Fuess, S; Gadfort, T; Galea, C F; Gallas, E; Galyaev, E; García, C; García-Bellido, A; Gardner, J; Gavrilov, V; Gay, A; Gay, P; Gelé, D; Gelhaus, R; Gerber, C E; Gershtein, Yu; Gillberg, D; Ginther, G; Gollub, N; Gómez, B; Goussiou, A; Grannis, P D; Greenlee, H; Greenwood, Z D; Gregores, E M; Grenier, G; Gris, P; Grivaz, J F; Grünendahl, S; Grünewald, M W; Guo, F; Guo, J; Gutíerrez, G; Gutíerrez, P; Haas, A; Hadley, N J; Haefner, P; Hagopian, S; Haley, J; Hall, I; Hall, R E; Han, L; Hanagaki, K; Hansson, P; Harder, K; Harel, A; Harrington, R; Hauptman, J M; Hauser, R; Hays, J; Hebbeker, T; Hedin, D; Hegeman, J G; Heinmiller, J M; Heinson, A P; Heintz, U; Hensel, C; Herner, K; Hesketh, G; Hildreth, M D; Hirosky, R; Hobbs, J D; Hoeneisen, B; Hoeth, H; Hohlfeld, M; Hong, S J; Hooper, R; Houben, P; Hu, Y; Hubacek, Z; Hynek, V; Iashvili, I; Illingworth, R; Ito, A S; Jabeen, S; Jaffré, M; Jain, S; Jakobs, K; Jarvis, C; Jenkins, A; Jesik, R; Johns, K; Johnson, C; Johnson, M; Jonckheere, A; Jonsson, P; Juste, A; Käfer, D; Kahn, S; Kajfasz, E; Kalinin, A M; Kalk, J M; Kalk, J R; Kappler, S; Karmanov, D; Kasper, J; Kasper, P; Katsanos, I; Kau, D; Kaur, R; Kehoe, R; Kermiche, S; Khalatyan, N; Khanov, A; Kharchilava, A I; Kharzheev, Yu M; Khatidze, D; Kim, H; Kim, T J; Kirby, M H; Klima, B; Kohli, J M; Konrath, J P; Kopal, M; Korablev, V M; Kotcher, J; Kothari, B; Koubarovsky, A; Kozelov, A V; Krop, D; Kryemadhi, A; Kühl, T; Kumar, A; Kunori, S; Kupco, A; Kurca, T; Kvita, J; Lammers, S; Landsberg, G L; Lazoflores, J; Le Bihan, A C; Lebrun, P; Lee, W M; Leflat, A; Lehner, F; Lesne, V; Lévêque, J; Lewis, P; Li, J; Li, Q Z; Lima, J G R; Lincoln, D; Linnemann, J; Lipaev, V V; Lipton, R; Liu, Z; Lobo, L; Lobodenko, A; Lokajícek, M; Lounis, A; Love, P; Lubatti, H J; Lynker, M; Lyon, A L; Maciel, A K A; Madaras, R J; Mättig, P; Magass, C; Magerkurth, A; Magnan, A M; Makovec, N; Mal, P K; Malbouisson, H B; Malik, S; Malyshev, V L; Mao, H S; Maravin, Y; Martens, M; McCarthy, R; Meder, D; Melnitchouk, A; Mendes, A; Mendoza, L; Merkin, M; Merritt, K W; Meyer, A; Meyer, J; Michaut, M; Miettinen, H; Millet, T; Mitrevski, J; Molina, J; Mondal, N K; Monk, J; Moore, R W; Moulik, T; Muanza, G S; Mulders, M; Mulhearn, M; Mundal, O; Mundim, L; Mutaf, Y D; Nagy, E; Naimuddin, M; Narain, M; Naumann, N A; Neal, H A; Negret, J P; Neustroev, P; Nöding, C; Nomerotski, A; Novaes, S F; Nunnemann, T; O'Dell, V; O'Neil, D C; Obrant, G; Oguri, V; Oliveira, N; Onoprienko, D; Oshima, N; Otec, R; Oteroy-Garzon, G J; Owen, M; Padley, P; Parashar, N; Park, S J; Park, S K; Parsons, J; Partridge, R; Parua, N; Patwa, A; Pawloski, G; Perea, P M; Pérez, E; Peters, K; Petroff, P; Petteni, M; Piegaia, R; Piper, J; Pleier, M A; Podesta-Lerma, P L M; Podstavkov, V M; Pogorelov, Y; Pol, M E; Pompos, A; Pope, B G; Popov, A V; Potter, C; Prado da Silva, W L; Prosper, H B; Protopopescu, S D; Qian, J; Quadt, A; Quinn, B; Rangel, M S; Rani, K J; Ranjan, K; Ratoff, P N; Renkel, P; Reucroft, S; Rijssenbeek, M; Ripp-Baudot, I; Rizatdinova, F K; Robinson, S; Rodrigues, R F; Royon, C; Rubinov, P; Ruchti, R; Rud, V I; Sajot, G; Sánchez-Hernández, A; Sanders, M P; Santoro, A F S; Savage, G; Sawyer, L; Scanlon, T; Schaile, A D; Schamberger, R D; Scheglov, Y; Schellman, H; Schieferdecker, P; Schmitt, C; Schwanenberger, C; Schwartzman, A; Schwienhorst, R; Sekaric, J; Sen-Gupta, S; Severini, H; Shabalina, E; Shamim, M; Shary, V; Shchukin, A A; Shephard, W D; Shivpuri, R K; Shpakov, D; Siccardi, V; Sidwell, R A; Simák, V; Sirotenko, V I; Skubic, P L; Slattery, P F; Smith, R P; Snow, G R; Snow, J; Snyder, S; Söldner-Rembold, S; Song, X; Sonnenschein, L; Sopczak, A; Sosebee, M; Soustruznik, K; Souza, M; Spurlock, B; Stark, J; Steele, J; Stolin, V; Stone, A; Stoyanova, D A; Strandberg, J; Strandberg, S; Strang, M A; Strauss, M; Ströhmer, R; Strom, D; Strovink, M; Stutte, L; Sumowidagdo, S; Svoisky, P; Sznajder, A; Talby, M; Tamburello, P; Taylor, W; Telford, P; Temple, J; Tiller, B; Titov, M; Tokmenin, V V; Tomoto, M; Toole, T; Torchiani, I; Towers, S; Trefzger, T; Trincaz-Duvoid, S; Tsybychev, D; Tuchming, B; Tully, C; Turcot, A S; Tuts, P M; Unalan, R; Uvarov, L; Uvarov, S; Uzunyan, S; Vachon, B; vanden Berg, P J; Van Kooten, R; Van Leeuwen, W M; Varelas, N; Varnes, E W; Vartapetian, A H; Vasilyev, I A; Vaupel, M; Verdier, P; Vertogradov, L S; Verzocchi, M; Villeneuve-Séguier, F; Vint, P; Vlimant, J R; Von Törne, E; Voutilainen, M; Vreeswijk, M; Wahl, H D; Wang, L; Wang, M H L; Warchol, J; Watts, G; Wayne, M; Weber, G; Weber, M; Weerts, H; Wermes, N; Wetstein, M; White, A; Wicke, D; Wilson, G W; Wimpenny, S J; Wobisch, M; Womersley, J; Wood, D R; Wyatt, T R; Xie, Y; Xuan, N; Yacoob, S; Yamada, R; Yan, M; Yasuda, T; Yatsunenko, Y A; Yip, K; Yoo, H D; Youn, S W; Yu, C; Yu, J; Yurkewicz, A; Zatserklyaniy, A; Zeitnitz, C; Zhang, D; Zhao, T; Zhou, B; Zhu, J; Zielinski, M; Zieminska, D; Zieminski, A; Zutshi, V; Zverev, E G

    2006-01-01

    We report on a measurement of the $B^0_d$ mixing frequency and the calibration of an opposite-side flavor tagger in the D{\\O}experiment. Various properties associated with the $b$ quark on the opposite side of the reconstructed $B$ meson were combined using a likelihood-ratio method into a single variable with enhanced tagging power. Its performance was tested with data, using a large sample of reconstructed semileptonic $B \\to \\mu \\dzero X$ and $B \\to \\mu \\dst X$ decays, corresponding to an integrated luminosity of approximately 1 fb$^{-1}$. The events were divided into groups depending on the value of the combined tagging variable, and an independent analysis was performed in each group. Combining the results of these analyses, the overall effective tagging power was found to be eD^2 = (2.48 \\pm 0.21 (stat.) ^{+0.08}_{-0.06} (syst.))%. The measured $B^0_d$ mixing frequency dmd = 0.506 \\pm 0.020 {\\rm (stat) \\pm 0.016 (syst) ps}^{-1} is in good agreement with the world average value.

  9. Produktie en afzet van BD- en EKO - produkten

    NARCIS (Netherlands)

    Kleijn, de E.H.J.M.; Groenwold, J.G.; Hack, M.D.

    1990-01-01

    This is the report of a research on the structure and general results of biodynamic and ecological agriculture in The Netherlands. Questionnaires and interviews are used to gather data on the primary production, marketing and processing. The demand and consumer aspects are analysed with the help of

  10. Producing 88,000 bd. in the tar belt

    Energy Technology Data Exchange (ETDEWEB)

    Finken, R.E.; Meldau, R.F.

    1972-08-01

    The Phillips Petroleum Co. and its associates have completed the necessary work for producing, treating and transporting 88,000 bopd of crude oil from the Oil Belt of the Orinoco, in the E. part of Venezuela. The first step consisted in assembling the means for diluting the 8$ API crude, coming from the producing horizons of the Morichal field. The second step was the drilling of 41 wells in the Jobo field. The final step consisted in the upgrading of the means of treatment, the pipelining and equipment for handling the increased production. The solvent which is used to dilute the heavy crude comes to the port by tanker and is pumped through a new pipeline to the field, where distribution lines take it to the various wells. Here it is pumped down the tubing to a point above the pump (which is located above a production packer) and then out the annulus. During this cycle the heavy crude is diluted with the light solvent to a consistency where it is manageable. The producing sands of the Tar Belt have a reserve estimate of 700-billion barrels of recoverable oil. Phillips also makes extensive use of thermal recovery methods in producing these wells.

  11. Observation of a new D_sJ meson in B+->D0BD0K+ decays

    CERN Document Server

    Brodzicka, J; Adachi, I; Aihara, H; Aulchenko, V; Bakich, A M; Barberio, E; Bay, A; Bedny, I; Bitenc, U; Bondar, A; Bracko, M; Browder, T E; Chang, M C; Chang, P; Chen, A; Chen, W T; Cheon, B G; Chiang, C C; Chistov, R; Cho, I S; Choi, S K; Choi, Y; Dalseno, J; Danilov, M; Dash, M; Drutskoy, A; Eidelman, S; Gabyshev, N; Go, A; Gokhroo, G; Golob, B; Ha, H; Haba, J; Hara, T; Hayasaka, K; Hayashii, H; Hazumi, M; Heffernan, D; Hoshi, Y; Hou, W S; Hyun, H J; Iijima, T; Ikado, K; Inami, K; Ishikawa, A; Ishino, H; Itoh, R; Iwasaki, M; Iwasaki, Y; Joshi, N J; Kah, D H; Kang, J H; Kawai, H; Kawasaki, T; Kichimi, H; Kim, H O; Kim, S K; Kim, Y J; Kinoshita, K; Korpar, S; Krokovny, P; Kumar, R; Kuo, C C; Kwon, Y J; Lange, J S; Lee, J S; Lee, M J; Lee, S E; Lesiak, T; Limosani, A; Liventsev, D; Mandl, F; McOnie, S; Medvedeva, T; Mitaroff, W A; Miyabayashi, K; Miyake, H; Miyata, H; Mizuk, R; Mori, T; Nagasaka, Y; Nakano, E; Nakao, M; Natkaniec, Z; Nishida, S; Nitoh, O; Noguchi, S; Nozaki, T; Ogawa, S; Ohshima, T; Okuno, S; Ozaki, H; Pakhlov, P; Pakhlova, G; Park, C W; Park, H; Pestotnik, R; Piilonen, L E; Rózanska, M; Sakai, Y; Schneider, O; Seidl, R; Sekiya, A; Senyo, K; Sevior, M E; Shapkin, M; Shen, C P; Shibuya, H; Shiu, J G; Singh, J B; Sokolov, A; Somov, A; Stanic, S; Staric, M; Sumiyoshi, T; Takasaki, F; Tamai, K; Tanaka, M; Taylor, G N; Teramoto, Y; Tikhomirov, I; Uehara, S; Ueno, K; Uglov, T; Unno, Y; Uno, S; Urquijo, P; Varner, G; Vervink, K; Villa, S; Vinokurova, A; Wang, C C; Wang, C H; Wang, M Z; Wang, P; Watanabe, Y; Wedd, R; Won, E; Yabsley, B D; Yamaguchi, A; Yamashita, Y; Yamauchi, M; Yuan, C Z; Yusa, Y; Zhang, C C; Zhang, Z P; Zhilich, V; Zhulanov, V; Zupanc, A; Zwahlen, N

    2007-01-01

    We report the observation of a new $D_{sJ}$ meson produced in $B^{+} \\to \\bar{D}^{0} D_{sJ} \\to \\bar{D}^{0} D^{0} K^{+}$. This state has a mass of $M=2708 \\pm 9 ^{+11}_{-10} \\rm{MeV}/{\\it c}^{2}$, a width $\\Gamma = 108 \\pm 23 ^{+36}_{-31} ~\\rm{MeV}/ {\\it c}^{2}$ and a $1^{-}$ spin-parity. The results are based on an analysis of 449 million $B\\bar{B}$ events collected at the $\\Upsilon(4S)$ resonance with the Belle detector at the KEKB asymmetric-energy $e^{+} e^{-}$ collider.

  12. 基于溶剂化效应的BD E-15分子振动光谱增强特征振动研究%Study on Enhancing Characteristic Vibration of the Molecular Vibration Spectrum for BDE-15 Based on Solvent Effect

    Institute of Scientific and Technical Information of China (English)

    姜龙; 孟冲; 李鱼

    2015-01-01

    利用密度泛函与自洽反应场理论在B3LYP/6-31+G(d)水平下分别计算气态及24种不同极性溶剂中4,4’-二溴二苯醚(4,4’-dibrominated diphenyl ethers ,BDE-15)的分子振动光谱(红外光谱、拉曼光谱),以气态分子振动光谱为基准,筛选出对溶剂极性敏感的特征振动作为指标构建溶剂对BDE-15振动光谱溶剂化效应指标体系,探究溶剂对BDE-15分子振动频率、红外/拉曼峰强溶剂化效应及综合效应,并寻求显著增强BDE-15分子特征振动频移/强度的溶剂。研究表明:从分子振动频率角度,溶剂极性敏感的(频移>1 cm -1)分子特征振动均为伸缩振和面外弯曲振,但24种溶剂对BDE-15分子振动频率溶剂化效应并不显著;从分子振动峰强角度,24种溶剂对BDE-15分子振动光谱峰强的增强效应主要发生在红外光谱的中低频区及拉曼光谱的高频区,其中起显著增强(红外/拉曼效应指标值分别大于6与5)的溶剂为醇类、乙腈、二甲亚砜、硝基苯;不同极性溶剂对BDE-15拉曼峰强溶剂化效应及综合效应指标值均表现出随溶剂介电常数增长由线性到对数的增长趋势,而红外峰强只保留低介电常数溶剂时的线性关系。利用上述BD E-15分子振动光谱峰强增强方法对BDE-153,BDE-154和BDE-209进行验证,醇类、乙腈、二甲亚砜、硝基苯对三者的振动光谱红外/拉曼峰强的效应指标值分别大于6与5,且最大峰强增倍数皆大于33,说明所建BDE-15分子振动光谱增强特征振动方法有助于进一步开展基于分子振动光谱的PBDEs同系物间辨识研究。%In this paper ,the molecular vibrational spectra (IR spectra and Raman spectra) of 4 ,4’-dibrominated diphenyl ethers (BDE-15) in atmosphere and 24 kinds of solvents were calculated ,at the B3LYP/6-31+G(d) level by density functional theory and self-consistent reaction field

  13. 76 FR 17062 - Special Conditions: Bombardier Model BD-700-1A10 and BD-700-1A11 Airplanes, Head-Up Display (HUD...

    Science.gov (United States)

    2011-03-28

    ... & Environmental Standards for Components and Areas Not Affected by the Change The original certification basis for.... Airworthiness and Environmental Standards for Components and Areas Affected by the Change 14 CFR part...

  14. 76 FR 31223 - Special Conditions: Bombardier Model BD-700-1A10 and BD-700-1A11 Airplanes, Head-up Display (HUD...

    Science.gov (United States)

    2011-05-31

    ...: Airworthiness & Environmental Standards for Components and Areas Not Affected by the Change The original..., Revision 13. Airworthiness and Environmental Standards for Components and Areas Affected by the Change 14... FR 17062). No comments were received, and the special conditions are adopted as...

  15. 76 FR 17582 - Special Conditions: Bombardier Model BD-700-1A10 and BD-700-1A11 Airplanes, Head-Up Display (HUD...

    Science.gov (United States)

    2011-03-30

    ... & Environmental Standards for Components and Areas Not Affected by the Change The original certification basis for.... Airworthiness and Environmental Standards for Components and Areas Affected by the Change 14 CFR part...

  16. 78 FR 65233 - Special Conditions: Bombardier Inc., Models BD-500-1A10 and BD-500-1A11 Series Airplanes...

    Science.gov (United States)

    2013-10-31

    ... have a novel or unusual design feature associated with aluminum-lithium fuselage construction that may provide different levels of protection from post-crash fire threats than similar aircraft constructed from..., Washington, DC 20590-0001. Hand Delivery or Courier: Take comments to Docket Operations in Room W12-140...

  17. 78 FR 65231 - Special Conditions: Bombardier Inc., Models BD-500-1A10 and BD-500-1A11 series airplanes...

    Science.gov (United States)

    2013-10-31

    ... scenarios. While these tests were developed for thermal/acoustic insulation materials, this same type of... scenario. The FAA recently conducted additional testing in our Components Fire Test facility and determined... the Burnthrough Resistance of Thermal/Acoustic Insulation Materials). Although this test method...

  18. 76 FR 66198 - Airworthiness Directives; Bombardier, Inc. Model BD-700-1A10 and BD-700-1A11 Airplanes

    Science.gov (United States)

    2011-10-26

    ... receive about this proposed AD. Discussion The Transport Canada Civil Aviation (TCCA), which is the..., 9403, and subsequent. This has been coordinated with the Transport Canada Civil Aviation (TCCA). Other... MCAI Transport Canada Civil Aviation (TCCA) Airworthiness Directive CF-2011-10, dated May 13,...

  19. 75 FR 31731 - Airworthiness Directives; Bombardier, Inc. Model BD-700-1A10 and BD-700-1A11 Airplanes

    Science.gov (United States)

    2010-06-04

    ... Civil Aviation (TCCA), which is the aviation authority for Canada, has issued Canadian Airworthiness... coordinated with Transport Canada Civil Aviation (TCCA). Other FAA AD Provisions (k) The following provisions...) Refer to MCAI Transport Canada Civil Aviation (TCCA) Airworthiness Directive CF-2010-01, dated...

  20. 78 FR 65156 - Special Conditions: Bombardier Inc., Models BD-500-1A10 and BD-500-1A11 Series Airplanes...

    Science.gov (United States)

    2013-10-31

    .... In particular, any significant nonlinearity (rate of displacement of control surface, thresholds, or... maintained. (iv) Failures of the system that result in forced structural vibrations (e.g.,...

  1. Measurement of the B_d0 lifetime using B_d0 to J/psi K0_S decays at Dzero

    Energy Technology Data Exchange (ETDEWEB)

    Balm, Paul W

    2004-12-01

    This thesis describes a measurement of the B{sub d}{sup 0} lifetime in the decay to (J/{psi}K{sub S}{sup 0}), using 114 pb{sup -1} of data collected by the D0 experiment at the Tevatron from October 15, 2002, to June 10, 2003. The measurement is motivated by the tests of the Standard Model that it makes possible. These include tests of Heavy Quark Effective Theory predicting B-meson lifetimes, and of the complex phase in the CKM-matrix as the source of CP-violation in B{sub d}{sup 0} decays to (J/{psi}K{sub S}{sup 0}).

  2. Guilhem de Saint Gregori, "Ben grans avolesa intra" (BdT 233.2; Bartolomeo Zorzi, "En tal dezir mos cors intra" (BdT 74.4

    Directory of Open Access Journals (Sweden)

    Alessandro Bampa

    2014-02-01

    Full Text Available This paper provides a commentary and translation of two contrafacta of Arnaut Daniel’s sestina: Guilhem de Saint Gregori’s "Ben gran avolesa intra" and Bartolomeo Zorzi’s "En tal dezir mos cors intra". For the first song, I will highlight the new contexts and meanings given to Arnaut’s images (which are taken from his sestina and other poems within Guilhem’s invective against Aimers II of Poitiers, in order to evaluate its literary qualities and innovations. Through lexical analysis, this paper will reveal the strong connection between Zorzi’s and Guilhem’s songs. In particular, the paper analyses specifically their common theme of Hell, suggesting Bartolomeo’s text is most likely an answer to Arnaut’s sestina, which clearly expresses a desire of sensual pleasure. The study pays particular attention to the relation between sexual love and the matter of eternal damnation: Zorzi attacks Arnaut’s ferm voler, advancing his argument by evoking Chrétien de Troyes’ "Perceval" (references to which are spread throughout the text, and not only in l. 18 and through his constant stress on the duties towards one’s family.

  3. Massive MIMO Codebook Design Based on BD-DFT Extension%基于BD-DFT扩展的大规模MIMO码本设计

    Institute of Scientific and Technical Information of China (English)

    李小兵; 吴学文; 景小荣

    2015-01-01

    考虑到大规模多输入多输出(Multiple Input Multiple Output,MIMO)阵列尺寸及外形等因素的限制,提出了一种适用于基站,采用交叉极化天线面阵的大规模MIMO(Massive MIMO)码本设计方法.该方法综合考虑交叉极化信道的对角化特点和相邻天线之间的相关性,首先设计出与采用交叉极化线阵匹配的码本,进而利用垂直维度天线间的相关性对其进行扩展,最终生成与交叉极化面阵相匹配的码本.仿真结果表明,该码本设计方法可使大规模MIMO系统的传输速率和误码率性能得到明显地提升.

  4. 78 FR 67291 - Special Conditions: Bombardier Inc., Models BD-500-1A10 and BD-500-1A11 Series Airplanes; Design...

    Science.gov (United States)

    2013-11-12

    ... design feature associated with an electronic flight control system that provides roll control of the... design features: The airplanes are equipped with an electronic flight control system that provides... Airplanes; Design Roll Maneuver Condition AGENCY: Federal Aviation Administration (FAA), DOT. ACTION:...

  5. 78 FR 75284 - Special Conditions: Bombardier Inc., Models BD-500-1A10 and BD-500-1A11 Series Airplanes; Flight...

    Science.gov (United States)

    2013-12-11

    ... airplanes will incorporate the following novel or unusual design features: An electronic flight control...-1A11 series airplanes. These airplanes will have a novel or unusual design feature associated with an electronic flight control system that contains fly-by-wire control laws, including envelope protections,...

  6. 78 FR 76736 - Special Conditions: Bombardier Inc., Models BD-500-1A10 and BD-500-1A11 Series Airplanes; Side...

    Science.gov (United States)

    2013-12-19

    ... associated with side stick controllers for pitch and roll control instead of conventional wheels and columns... the comment for an association, business, labor union, etc.). DOT's complete Privacy Act Statement can.... The Bombardier C-series airplanes will use side stick controllers for pitch and roll...

  7. 78 FR 75285 - Special Conditions: Bombardier Inc., Models BD-500-1A10 and BD-500-1A11 Series Airplanes; Flight...

    Science.gov (United States)

    2013-12-11

    ... name of the individual sending the comment (or signing the comment for an association, business, labor... control systems (mechanical linkages) are limited in the pitch axis only by the elevator surface area and... pitch up is satisfactory. d. Maximum achievable negative load factor may be limited by...

  8. Lexicon of optics. Vol.1: A to L. Vol.2: M to Z; Lexikon der Optik. Bd. 1: A bis L. Bd. 2: M-Z

    Energy Technology Data Exchange (ETDEWEB)

    Paul, H. (ed.)

    2003-07-01

    This lexicon contains the actual knowledge for all aspects in optical sciences and technology. More than 4.000 headings are leading through the whole science of optics in two volumes together with more than 800 figures. More than 70 high-ranked authors guarantee the uptodate knowledge.

  9. 78 FR 76734 - Special Conditions: Bombardier Inc., Models BD-500-1A10 and BD-500-1A11 Series Airplanes; Seats...

    Science.gov (United States)

    2013-12-19

    ... be found in the Federal Register published on April 11, 2000 (65 FR 19477-19478), as well as at http...- bubble fuselage, sized for nominal 5-abreast seating. Each airplane's powerplant consists of two under...\\ installed per seat place. The panel may consist of either a single component or multiple components in...

  10. 78 FR 75287 - Special Conditions: Bombardier Inc., Models BD-500-1A10 and BD-500-1A11 Series Airplanes; Flight...

    Science.gov (United States)

    2013-12-11

    ... Privacy Act Statement can be found in the Federal Register published on April 11, 2000 (65 FR 19477-19478..., blended double- bubble fuselage, sized for nominal 5-abreast seating. Each airplane's powerplant consists... significant change (or multiple changes) occurs in the EFCS control laws as the limit is approached...

  11. Measurement of branching fraction and CP asymmetries in B->D0(cp)K decays

    CERN Document Server

    Aubert, B; Boutigny, D; Karyotakis, Yu; Lees, J P; Poireau, V; Prudent, X; Tisserand, V; Zghiche, A; Garra Tico, J; Graugès-Pous, E; López, L; Palano, A; Pappagallo, M; Eigen, G; Stugu, B; Sun, L; Abrams, G S; Battaglia, M; Brown, D N; Button-Shafer, J; Cahn, R N; Groysman, Y; Jacobsen, R G; Kadyk, J A; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; Lopes-Pegna, D; Lynch, G; Mir, L M; Orimoto, T J; Osipenkov, I L; Ronan, M T; Tackmann, K; Tanabé, T; Wenzel, W A; Del Amo-Sánchez, P; Hawkes, C M; Watson, A T; Koch, H; Schröder, T; Walker, D; Asgeirsson, D J; Çuhadar-Dönszelmann, T; Fulsom, B G; Hearty, C; Mattison, T S; McKenna, J A; Khan, A; Saleem, M; Teodorescu, L; Blinov, V E; Bukin, A D; Druzhinin, V P; Golubev, V B; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Todyshev, K Yu; Bondioli, M; Curry, S; Eschrich, I; Kirkby, D; Lankford, A J; Lund, P; Mandelkern, M; Martin, E C; Stoker, D P; Abachi, S; Buchanan, C; Foulkes, S D; Gary, J W; Liu, F; Long, O; Shen, B C; Vitug, G M; Zhang, L; Paar, H P; Rahatlou, S; Sharma, V; Berryhill, J W; Campagnari, C; Cunha, A; Dahmes, B; Hong, T M; Kovalskyi, D; Richman, J D; Beck, T W; Eisner, A M; Flacco, C J; Heusch, C A; Kroseberg, J; Lockman, W S; Schalk, T; Schumm, B A; Seiden, A; Wilson, M G; Winstrom, L O; Chen, E; Cheng, C H; Fang, F; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Andreassen, R; Mancinelli, G; Meadows, B T; Mishra, K; Sokoloff, M D; Blanc, F; Bloom, P C; Chen, S; Ford, W T; Hirschauer, J F; Kreisel, A; Nagel, M; Nauenberg, U; Olivas, A; Smith, J G; Ulmer, K A; Wagner, S R; Zhang, J; Gabareen, A M; Soffer, A; Toki, W H; Wilson, R J; Winklmeier, F; Altenburg, D D; Feltresi, E; Hauke, A; Jasper, H; Karbach, M; Merkel, J; Petzold, A; Spaan, B; Wacker, K; Klose, V; Kobel, M J; Lacker, H M; Mader, W F; Nogowski, R; Schubert, J; Schubert, K R; Schwierz, R; Sundermann, J E; Volk, A; Bernard, D; Bonneaud, G R; Latour, E; Lombardo, V; Thiebaux, C; Verderi, M; Clark, P J; Gradl, W; Muheim, F; Playfer, S; Robertson, A I; Watson, J E; Xie, Y; Andreotti, M; Bettoni, D; Bozzi, C; Calabrese, R; Cecchi, A; Cibinetto, G; Franchini, P; Luppi, E; Negrini, M; Petrella, A; Piemontese, L; Prencipe, E; Santoro, V; Anulli, F; Baldini-Ferroli, R; Calcaterra, A; De Sangro, R; Finocchiaro, G; Pacetti, S; Patteri, P; Peruzzi, I M; Piccolo, M; Rama, M; Zallo, A; Buzzo, A; Contri, R; Lo Vetere, M; Macri, M M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Chaisanguanthum, K S; Morii, M; Wu, J; Dubitzky, R S; Marks, J; Schenk, S; Uwer, U; Bard, D J; Dauncey, P D; Flack, R L; Nash, J A; Panduro-Vazquez, W; Tibbetts, M; Behera, P K; Chai, X; Charles, M J; Mallik, U; Cochran, J; Crawley, H B; Dong, L; Eyges, V; Meyer, W T; Prell, S; Rosenberg, E I; Rubin, A E; Gao, Y Y; Gritsan, A V; Guo, Z J; Lae, C K; Denig, A G; Fritsch, M; Schott, G; Arnaud, N; Bequilleux, J; D'Orazio, A; Davier, M; Grosdidier, G; Höcker, A; Lepeltier, V; Le Diberder, F; Lutz, A M; Pruvot, S; Rodier, S; Roudeau, P; Schune, M H; Serrano, J; Sordini, V; Stocchi, A; Wang, W F; Wormser, G; Lange, D J; Wright, D M; Bingham, I; Burke, J P; Chavez, C A; Fry, J R; Gabathuler, E; Gamet, R; Hutchcroft, D E; Payne, D J; Schofield, K C; Touramanis, C; Bevan, A J; George, K A; Di Lodovico, F; Sacco, R; Cowan, G; Flächer, H U; Hopkins, D A; Paramesvaran, S; Salvatore, F; Wren, A C; Brown, D N; Davis, C L; Allison, J; Bailey, D; Barlow, N R; Barlow, R J; Chia, Y M; Edgar, C L; Lafferty, G D; West, T J; Yi, J I; Anderson, J; Chen, C; Jawahery, A; Roberts, D A; Simi, G; Tuggle, J M; Blaylock, G; Dallapiccola, C; Hertzbach, S S; Li, X; Moore, T B; Salvati, E; Saremi, S; Cowan, R; Dujmic, D; Fisher, P H; Koeneke, K; Sciolla, G; Spitznagel, M; Taylor, F; Yamamoto, R K; Zhao, M; Zheng, Y; Mclachlin, S E; Patel, P M; Robertson, S H; Lazzaro, A; Palombo, F; Bauer, J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Côté, D; Simard, M; Taras, P; Viaud, F B; Nicholson, H; De Nardo, Gallieno; Fabozzi, F; Lista, L; Monorchio, D; Sciacca, C; Baak, M A; Raven, G; Snoek, H L; Jessop, C P; Knoepfel, K J; LoSecco, J M; Benelli, G; Corwin, L A; Honscheid, K; Kagan, H; Kass, R; Morris, J P; Rahimi, A M; Regensburger, J J; Sekula, S J; Wong, Q K; Blount, N L; Brau, J E; Frey, R; Igonkina, O; Kolb, J A; Lu, M; Rahmat, R; Sinev, N B; Strom, D; Strube, J; Torrence, E; Gagliardi, N; Gaz, A; Margoni, M; Morandin, M; Pompili, A; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Voci, C; Ben-Haim, E; Briand, H; Calderini, G; Chauveau, J; David, P; Del Buono, L; De La Vaissière, C; Hamon, O; Leruste, P; Malcles, J; Ocariz, J; Pérez, A; Prendki, J; Gladney, L; Biasini, M; Covarelli, R; Manoni, E; Angelini, C; Batignani, G; Bettarini, S; Carpinelli, M; Cenci, R; Cervelli, A; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Mazur, M A; Morganti, M; Neri, N; Paoloni, E; Rizzo, G; Walsh, J J; Biesiada, J; Elmer, P; Lau, Y P; Lü, C; Olsen, J; Smith, A J S; Telnov, A V; Baracchini, E; Bellini, F; Cavoto, G; Del Re, D; Di Marco, E; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Jackson, P D; Li Gioi, L; Mazzoni, M A; Morganti, S; Piredda, G; Polci, F; Renga, F; Voena, C; Ebert, M; Hartmann, T; Schröder, H; Waldi, R; Adye, T; Castelli, G; Franek, B; Olaiya, E O; Röthel, W; Wilson, F F; Emery, S; Escalier, M; Gaidot, A; Ganzhur, S F; Hamel de Monchenault, G; Kozanecki, W; Vasseur, G; Yéche, C; Zito, M; Chen, X R; Liu, H; Park, W; Purohit, M V; White, R M; Wilson, J R; Allen, M T; Aston, D; Bartoldus, R; Bechtle, P; Claus, R; Coleman, J P; Convery, M R; Dingfelder, J C; Dorfan, J; Dubois-Felsmann, G P; Dunwoodie, W; Field, R C; Glanzman, T; Gowdy, S J; Graham, M T; Grenier, P; Hast, C; Innes, W R; Kaminski, J; Kelsey, M H; Kim, H; Kim, P; Kocian, M L; Leith, D W G S; Li, S; Luitz, S; Lüth, V; Lynch, H L; MacFarlane, D B; Marsiske, H; Messner, R; Müller, D R; O'Grady, C P; Ofte, I; Perazzo, A; Perl, M; Pulliam, T; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Snyder, A; Su, D; Sullivan, M K; Suzuki, K; Swain, S K; Thompson, J M; Vavra, J; Wagner, A P; Weaver, M; Wisniewski, W J; Wittgen, M; Wright, D H; Yarritu, A K; Yi, K; Young, C C; Ziegler, V; Burchat, P R; Edwards, A J; Majewski, S A; Miyashita, T S; Petersen, B A; Wilden, L; Ahmed, S; Alam, M S; Bula, R; Ernst, J A; Jain, V; Pan, B; Saeed, M A; Wappler, F R; Zain, S B; Krishnamurthy, M; Spanier, S M; Eckmann, R; Ritchie, J L; Ruland, A M; Schilling, C J; Schwitters, R F; Izen, J M; Lou, X C; Ye, S; Bianchi, F; Gallo, F; Gamba, D; Pelliccioni, M; Bomben, M; Bosisio, L; Cartaro, C; Cossutti, F; Della Ricca, G; Lanceri, L; Vitale, L; Azzolini, V; Lopez-March, N; Martínez-Vidal, F; Milanes, D A; Oyanguren, A; Albert, J; Banerjee, Sw; Bhuyan, B; Hamano, K; Kowalewski, R; Nugent, I M; Roney, J M; Sobie, R J; Harrison, P F; Ilic, J; Latham, T E; Mohanty, G B; Band, H R; Chen, X; Dasu, S; Flood, K T; Hollar, J J; Kutter, P E; Pan, Y; Pierini, M; Prepost, R; Wu, S L; Neal, H

    2007-01-01

    We present a preliminary study of $B^- \\to D^0_{CP} \\pi^-$ and $B^- \\to D^0_{CP} K^-$ decays, with the $D^0_{CP}$ reconstructed in the CP-odd eigenstates $K_s \\pi^0$, $K_s \\omega$, in the CP-even eigenstates $K^+ K^-$, $\\pi^+ \\pi^-$, and in the (non-CP) flavor eigenstate $K^\\mp \\pi^\\pm$. Using a sample of about 382 million Y(4S) decays into BBbar pairs, collected with the BABAR detector operating at the PEP-II asymmetric-energy B Factory at SLAC, we measure the ratios of the branching fractions R_CP+- and the direct CP asymmetries A_CP+-. The results are: R_CP- = 0.81 \\pm 0.10 (stat) \\pm 0.05 (syst) R_CP+ = 1.07 \\pm 0.10 (stat) \\pm 0.04 (syst) A_CP- = -0.19 \\pm 0.12 (stat) \\pm 0.02 (syst) A_CP+ = 0.35 \\pm 0.09 (stat) \\pm 0.05 (syst)

  12. Draft genome sequence of Francisella tularensis subsp. holarctica BD11-00177

    NARCIS (Netherlands)

    Coolen, J.P.M.; Sjödin, A.; Maraha, B.; Hajer, G.F.; Forsman, M.; Verspui, E.; Frenay, H.M.E.; Notermans, D.W.; Vries, M.C. de; Reubsaet, F.A.G.; Paauw, A.; Roeselers, G.

    2013-01-01

    Francisella tularensis is a facultative intracellular bacterium in the class Gammaproteobacteria. This strain is of interest because it is the etiologic agent of tularemia and a highly virulent category A biothreat agent. Here we describe the draft genome sequence and annotation of Francisella tular

  13. DECHEMA annual conference in 1998; DECHEMA-Jahrestagungen `98. Bd. 1. 16. Jahrestagung der Biotechnologen. Kurzfassungen

    Energy Technology Data Exchange (ETDEWEB)

    Hess, C. [comp.

    1998-12-31

    In a versatile, often multidisciplinary programme the DECHEMA annual conferences in 1998 present new results from research, the state of the art, and, not least, the persons, companies, and institutions active in various disciplines. This volume contains shortened versions of the lectures and posters presented at the 16th Annual Conference of Biotechnologists. [Deutsch] Die DECHEMA-Jahrestagungen `98 stellen in einem vielseitigen, oft interdisziplinaeren Programm neue Ergebnisse aus der Forschung, den aktuellen Stand der Technik und nicht zuletzt auch die auf den jeweiligen Gebieten aktiven Personen, Firmen und Institutionen vor. In diesem Band sind die Kurzfassungen der Vortraege und Poster der 16. Jahrestagung der Biotechnologen enthalten. (orig.)

  14. Experimental radiotherapy and clinical radiobiology. Vol. 16; Experimentelle Strahlentherapie und Klinische Strahlenbiologie. Bd. 16. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, M.; Dahm-Daphi, J.; Dikomey, E.; Petersen, C.; Rodemann, H.P.; Zips, D. (eds.)

    2007-07-01

    The following topics were dealt with: DNA repair as therapeutical target in radiation therapy, biological imaging and tumor microenvironment, molecular factors of radiation therapy, molecular factors and modulation of the radiation reaction of normal tissues, experimental tumor therapy, EGFR inhibition, the endothel cell as primary target of radiation therapy, molecular and cellular foundations of the radiation biology of protons and ions. (HSI)

  15. Peire Vidal, “Bon’aventura don Dieus als Pizas” (BdT 364.14

    Directory of Open Access Journals (Sweden)

    Marco Grimaldi

    2013-05-01

    Full Text Available The poem examined here, probably composed in Italy, is mainly known for its historical interest and as a satire of the Germans. In “Bon’aventura”, in fact, Peire Vidal seems to be siding openly with the Marquis Boniface I of Monferrato and the Lombard communes, that were at war with the Emperor Henry IV, who had invaded Italy at the end of 1194. This paper, which reproduces Avalle’s edition and basically confirms the usual date between autumn 1194 and April 1195, will discuss the precise relationship between poetry and politics in Peire Vidal’s work through an analysis of the song’s value as a document in relation to contemporary sources. Thus it will examine the troubadour’s attitude to the events of his day and attempt to outline a fluid and ‘regional’ political loyalty which the poet from Toulouse shares with his contemporaries.

  16. Mixing and CPV in the Bd and Bs systems at ATLAS

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00211684; The ATLAS collaboration

    2016-01-01

    The most recent results on mixing and $CP$ violation in the $B^0$ and $B_s^0$ systems, published by the ATLAS experiment at the LHC, are presented. The measurement of the $B_s^0 \\to J/\\psi \\phi$ decay parameters, using data collected in $p p$ collisions at $\\sqrt{s} = 7$ TeV and $\\sqrt{s} = 8$ TeV and corresponding to 4.9 fb$^{-1}$ and 14.3 fb$^{-1}$ of integrated luminosity, includes the $CP$-violating phase $\\phi_s$ and the width difference of the mass eigenstates $\\Delta\\Gamma_s$. The combined Run-1 results are $\\phi_s = -0.098 \\pm 0.084 \\mbox{(stat.)} \\pm 0.040 \\mbox{(syst.)}$ rad and $\\Delta\\Gamma_s = 0.083 \\pm 0.011 \\mbox{(stat.)} \\pm 0.007 \\mbox{(syst.)} ~\\mbox{ps}^{-1}$. The measured values agree with the Standard Model predictions. The second result presented is the measurement of the relative width difference $\\Delta \\Gamma_d / \\Gamma_d$ of the $B^0$--$\\bar B^0$ system, using data collected in $p p$ collisions at $\\sqrt{s} = 7$ TeV and $\\sqrt{s} = 8$ TeV, and corresponding to a total integrated lumi...

  17. Anonimo, “Totas honors e tuig faig benestan” (BdT 461.234

    Directory of Open Access Journals (Sweden)

    Marco Grimaldi

    2010-08-01

    Full Text Available This paper will examine an anonymous ‘planh’, “Totas honor e tuig faig benestan”, for the death of Manfred of Swabia, illegitimate son of Frederick II, who was killed in the battle of Benevento in 1266. The text is copied in a section of the ‘twin’ chansonniers I and K which contains mainly lyric laments (an exception in the troubadour manuscript tradition and for this reason will serve as a basis for a discussion of the concept of ‘documentary series’. The paper will also consider the author’s origin, probably Italian on the basis of the linguistic and metrical evidence, and attempt to place the planh more precisely within the context of the struggle between Charles of Anjou and Manfred, as well as illustrate the role played by political troubadour poetry at the Italian court of the last Swabians.

  18. Experimental radiotherapy and clinical radiobiology. Vol. 20. Proceedings; Experimentelle Strahlentherapie und Klinische Strahlenbiologie. Bd. 20. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, Michael; Dahm-Daphi, Jochen; Dikomey, Ekkehard; Petersen, Cordula; Rodemannn, Hans-Peter; Zips, Daniel (eds.)

    2011-07-01

    The proceedings include contributions on the following issues: laser driven proton accelerators on the way for radiotherapy, radiobiological evaluation of new radiations; molecular factors of radiation response; biological targeting; EGFR epidermal growth factor receptor/targeting - combined internal and external irradiation, radiobiology of normal tissues; dose-volume histograms for the radiotherapy: curves without radiobiological relevance or important information for the therapy planning; HPV (human papilloma virus) and radiation sensitivity of HNSCC (head and neck squamous cell carcinomas): evidence, radiobiological mechanism, clinical consequences and perspectives; mechanisms of action and intertumoral heterogeneity of response to EGFR inhibition in radiotherapy of solid tumors; evaluation of biomarkers for radiotherapy.

  19. Experimental radiotherapy and clinical radiobiology. Vol. 22. Proceedings; Experimentelle Strahlentherapie und Klinische Strahlenbiologie. Bd. 22. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, Michael; Cordes, Nils; Dikomey, Ekkehard; Krause, Mechthild; Petersen, Cordula; Rodemannn, H. Peter; Zips, Daniel (eds.)

    2013-03-01

    The proceedings of the 22th Symposium on experimental radiotherapy and clinical radiotherapy contain lectures and poster on the following issues: Radiation induced immuno-targeting of tumors; targeting in the radiotherapy; biomarkers; targeting; radio-oncological therapy of rectal carcinoma - contribution of radiobiology for therapy optimization; biomarkers for radiation sensibility; resistance mechanisms of tumors; resistance mechanisms of normal tissue; micro ambience, P13L inhibition in radiotherapy: improvement of the local tumor control by molecular mechanisms or the influence of the tumor micro-ambience? DNA repair; radiation effects and technical development.

  20. Peire del Vilar, “Sendatz vermelhs, endis e ros” (BdT 365.1

    Directory of Open Access Journals (Sweden)

    Linda Paterson

    2013-06-01

    Full Text Available This ‘sirventes’ presents a number of hermeneutic difficulties, both detailed and global. The issue of dating is also problematic, with some strong arguments in favour of either 1242 (Jeanroy or 1285 (Kendrick. Jeanroy understands the ‘sirventes’ to be announcing the imminent arrival of King Henry III of England to join forces with the southern uprising against France in 1242; Kendrick, as an attempt to persuade the audience, and specifically the count of Rodez, to oppose the attack on Aragon by Philip the Bold of France during the so-called Aragonese crusade. Fresh examination of a number of linguistic details suggests that stanzas I-IV are ironic in tone, and the historical references, including some not considered by previous scholars, vitiate Kendrick’s arguments and support Jeanroy’s dating.

  1. Platelet counting with the BD Accuri(TM) C6 flow cytometer.

    Science.gov (United States)

    Masters, Andrew; Harrison, Paul

    2014-01-01

    The Accuri™ C6 is a compact flow cytometer that uses a peristaltic pump with a laminar flow fluidic system and can measure absolute cell counts. In this study we have evaluated this method with the International Reference Method (IRM) simultaneously measured on both the Accuri™ C6 and a reference flow cytometer. After optimisation of sample labelling conditions, final dilutions and flow cytometer settings, a comparison of the absolute fluorescent platelet count with the RBC/platelet ratio on the C6 and the IRM was then performed in 144 patient samples with a full range of platelet counts (range 2-650 × 10(9)/l). The platelet/RBC ratio method determined on the Accuri™ agreed well with the IRM (R(2)=0.99, bias=2.3 (Bland Altman) and R(2)=0.96, bias=1.02 at counts <50 × 10(9)/l). The absolute platelet count also agreed well with the IRM (R(2)=0.97, bias=-0.16 and R(2)=0.91, bias=3.7 at <50 × 10(9)/l). The C6 absolute platelet count and RBC/platelet ratio methods also agreed well (R(2)=0.99, bias=-2.5 and R(2)=0.95, bias=2.71 at counts <50 × 10(9)/l). Reproducibility studies on the C6 gave CVs of <5% for the RB/platelet ratio and <12% for the absolute cell counts. The C6 also demonstrated excellent linearity on diluted samples with both volume and ratio methods (R(2)=0.99). As one might expect, the absolute platelet count is therefore slightly more inaccurate than the RBC/platelet ratio particularly at platelet counts <50 × 10(9)/l as it is likely to be more sensitive to pipetting error. The Accuri™ C6 provides a simple, rapid and reliable method for measuring platelet counts by either the RBC/platelet or direct volume methods. The direct volume method can also be used to determine platelet counts within purified platelet preparations or concentrates in the absence of RBC.

  2. Evaluating the BD-100R as a neutron spectrometer through pressure variation

    Energy Technology Data Exchange (ETDEWEB)

    White, B.H.; Ebert, D.D.; Munno, F.J. (Univ. of Maryland, College Park (USA))

    1989-11-01

    Investigators have evaluated the dose response of neutron bubble dosimeters for possible use as a personnel monitor. In addition, two types of neutron spectrometer devices using bubble dosimetry have been developed. One uses the variation of vapor pressure of mixtures of detection material to extract the neutron energy spectrum, while the other employs variation of applied pressure on a different material. Dosimeter response changes due to variation of applied pressure have been demonstrated by Ing and Birnboim at absolute pressures of 0.432 MPa and atmospheric pressure. This investigation is intended to demonstrate the determination of an unknown spectrum utilizing the dosimeter response (number of bubbles formed) as a function of the applied pressure.

  3. ALA-PDT of glioma cell micro-clusters in BD-IX rat brain

    Science.gov (United States)

    Madsen, Steen J.; Angell-Petersen, Even; Spetalen, Signe; Carper, Stephen W.; Ziegler, Sarah A.; Hirschberg, Henry

    2006-02-01

    A significant contributory factor to the poor prognosis of patients with glioblastoma multiforme is the inability of conventional treatments to eradicate infiltrating glioma cells. A syngeneic rat brain tumor model is used to investigate the effects of aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) on small clusters of tumor cells sequestered in normal brain. The intrinsic sensitivity of rat glioma cells to PDT was investigated by exposing ALA-incubated cells to a range of radiant exposures and irradiances using 635 nm light. Biodistribution studies were undertaken on tumor-bearing animals in order to determine the tumor selectivity of the photosensitizer following systemic administration (i.p.) of ALA. Effects of ALA-PDT on normal brain and gross tumor were evaluated using histopathology. Effects of PDT on isolated glioma cells in normal brain were investigated by treating animals 48 h after tumor cell implantation: a time when the micro-clusters of cells are protected by an intact blood-brain-barrier (BBB). Rat glioma cells in monolayer are susceptible to ALA-PDT - lower irradiances are more effective than higher ones. Fluorescence microscopy of frozen tissue sections showed that photosensitizer is produced with better than 200:1 tumor-to-normal tissue selectivity following i.p. ALA administration. ALA-PDT resulted in significant damage to both gross tumor and normal brain, however, the treatment failed to prolong survival of animals with newly implanted glioma cells compared to non-treated controls if the drug was delivered either i.p. or directly into the brain. In contrast, animals inoculated with tumor cells pre-incubated in vitro with ALA showed a significant survival advantage in response to PDT.

  4. Measurement of the $B_{d}^{0} - \\overline{B}_{d}^{0}$ oscillation frequency

    CERN Document Server

    Acciarri, M; Aguilar-Benítez, M; Ahlen, S P; Alcaraz, J; Alemanni, G; Allaby, James V; Aloisio, A; Alviggi, M G; Ambrosi, G; Anderhub, H; Andreev, V P; Angelescu, T; Anselmo, F; Arefev, A; Azemoon, T; Aziz, T; Bagnaia, P; Baksay, L; Ball, R C; Banerjee, S; Banerjee, Sw; Banicz, K; Barczyk, A; Barillère, R; Barone, L; Bartalini, P; Baschirotto, A; Basile, M; Battiston, R; Bay, A; Becattini, F; Becker, U; Behner, F; Berdugo, J; Berges, P; Bertucci, B; Betev, B L; Bhattacharya, S; Biasini, M; Biland, A; Bilei, G M; Blaising, J J; Blyth, S C; Bobbink, Gerjan J; Böck, R K; Böhm, A; Boldizsar, L; Borgia, B; Bourilkov, D; Bourquin, Maurice; Boutigny, D; Braccini, S; Branson, J G; Brigljevic, V; Brock, I C; Buffini, A; Buijs, A; Burger, J D; Burger, W J; Busenitz, J K; Cai, X D; Campanelli, M; Capell, M; Cara Romeo, G; Carlino, G; Cartacci, A M; Casaus, J; Castellini, G; Cavallari, F; Cavallo, N; Cecchi, C; Cerrada-Canales, M; Cesaroni, F; Chamizo-Llatas, M; Chang, Y H; Chaturvedi, U K; Chekanov, S V; Chemarin, M; Chen, A; Chen, G; Chen, G M; Chen, H F; Chen, H S; Chen, M; Chiefari, G; Chien, C Y; Cifarelli, Luisa; Cindolo, F; Civinini, C; Clare, I; Clare, R; Cohn, H O; Coignet, G; Colijn, A P; Colino, N; Costantini, S; Cotorobai, F; de la Cruz, B; Csilling, Akos; Dai, T S; D'Alessandro, R; De Asmundis, R; Degré, A; Deiters, K; Denes, P; De Notaristefani, F; DiBitonto, Daryl; Diemoz, M; Van Dierendonck, D N; Di Lodovico, F; Dionisi, C; Dittmar, Michael; Dominguez, A; Doria, A; Dova, M T; Drago, E; Duchesneau, D; Duinker, P; Durán, I; Dutta, S; Easo, S; Efremenko, Yu V; El-Mamouni, H; Engler, A; Eppling, F J; Erné, F C; Ernenwein, J P; Extermann, Pierre; Fabre, M; Faccini, R; Falciano, S; Favara, A; Fay, J; Fedin, O; Felcini, Marta; Fenyi, B; Ferguson, T; Ferroni, F; Fesefeldt, H S; Fiandrini, E; Field, J H; Filthaut, Frank; Fisher, P H; Fisk, I; Forconi, G; Fredj, L; Freudenreich, Klaus; Furetta, C; Galaktionov, Yu; Ganguli, S N; García-Abia, P; Gau, S S; Gentile, S; Gerald, J; Gheordanescu, N; Giagu, S; Goldfarb, S; Goldstein, J; Gong, Z F; Gougas, Andreas; Gratta, Giorgio; Grünewald, M W; Gupta, V K; Gurtu, A; Gutay, L J; Haas, D; Hartmann, B; Hasan, A; Hatzifotiadou, D; Hebbeker, T; Hervé, A; Hirschfelder, J; Van Hoek, W C; Hofer, H; Hoorani, H; Hou, S R; Hu, G; Innocente, Vincenzo; Jenkes, K; Jin, B N; Jones, L W; de Jong, P; Josa-Mutuberria, I; Kasser, A; Khan, R A; Kamrad, D; Kamyshkov, Yu A; Kapustinsky, J S; Karyotakis, Yu; Kaur, M; Kienzle-Focacci, M N; Kim, D; Kim, D H; Kim, J K; Kim, S C; Kinnison, W W; Kirkby, A; Kirkby, D; Kirkby, Jasper; Kiss, D; Kittel, E W; Klimentov, A; König, A C; Kopp, A; Korolko, I; Koutsenko, V F; Krämer, R W; Krenz, W; Kunin, A; Lacentre, P E; Ladrón de Guevara, P; Landi, G; Lapoint, C; Lassila-Perini, K M; Laurikainen, P; Lavorato, A; Lebeau, M; Lebedev, A; Lebrun, P; Lecomte, P; Lecoq, P; Le Coultre, P; Lee, H J; Leggett, C; Le Goff, J M; Leiste, R; Leonardi, E; Levchenko, P M; Li Chuan; Lin, C H; Lin, W T; Linde, Frank L; Lista, L; Liu, Z A; Lohmann, W; Longo, E; Lu, W; Lü, Y S; Lübelsmeyer, K; Luci, C; Luckey, D; Luminari, L; Lustermann, W; Ma Wen Gan; Maity, M; Majumder, G; Malgeri, L; Malinin, A; Maña, C; Mangeol, D J J; Mangla, S; Marchesini, P A; Marin, A; Martin, J P; Marzano, F; Massaro, G G G; McNally, D; Mele, S; Merola, L; Meschini, M; Metzger, W J; Von der Mey, M; Mi, Y; Migani, D; Mihul, A; Van Mil, A J W; Milcent, H; Mirabelli, G; Mnich, J; Molnár, P; Monteleoni, B; Moore, R; Moulik, T; Mount, R; Muheim, F; Muijs, A J M; Nahn, S; Napolitano, M; Nessi-Tedaldi, F; Newman, H; Niessen, T; Nippe, A; Nisati, A; Nowak, H; Oh, Yu D; Opitz, H; Organtini, G; Ostonen, R; Palit, S; Palomares, C; Pandoulas, D; Paoletti, S; Paolucci, P; Park, H K; Park, I H; Pascale, G; Passaleva, G; Patricelli, S; Paul, T; Pauluzzi, M; Paus, C; Pauss, Felicitas; Peach, D; Pei, Y J; Pensotti, S; Perret-Gallix, D; Petersen, B; Petrak, S; Pevsner, A; Piccolo, D; Pieri, M; Piroué, P A; Pistolesi, E; Plyaskin, V; Pohl, M; Pozhidaev, V; Postema, H; Produit, N; Prokofev, D; Prokofiev, D O; Quartieri, J; Rahal-Callot, G; Raja, N; Rancoita, P G; Rattaggi, M; Raven, G; Razis, P A; Read, K; Ren, D; Rescigno, M; Reucroft, S; Van Rhee, T; Riemann, S; Riles, K; Rind, O; Robohm, A; Rodin, J; Roe, B P; Romero, L; Rosier-Lees, S; Rosselet, P; Van Rossum, W; Roth, S; Rubio, Juan Antonio; Ruschmeier, D; Rykaczewski, H; Salicio, J; Sánchez, E; Sanders, M P; Sarakinos, M E; Sarkar, S; Sauvage, G; Schäfer, C; Shchegelskii, V; Schmidt-Kärst, S; Schmitz, D; Schneegans, M; Scholz, N; Schopper, Herwig Franz; Schotanus, D J; Schwenke, J; Schwering, G; Sciacca, C; Sciarrino, D; Servoli, L; Shevchenko, S; Shivarov, N; Shoutko, V; Shukla, J; Shumilov, E; Shvorob, A V; Siedenburg, T; Son, D; Soulimov, V; Smith, B; Spillantini, P; Steuer, M; Stickland, D P; Stone, H; Stoyanov, B; Strässner, A; Sudhakar, K; Sultanov, G G; Sun, L Z; Susinno, G F; Suter, H; Swain, J D; Tang, X W; Tauscher, Ludwig; Taylor, L; Ting, Samuel C C; Ting, S M; Tonwar, S C; Tóth, J; Tully, C; Tuchscherer, H; Tung, K L; Uchida, Y; Ulbricht, J; Uwer, U; Valente, E; Vesztergombi, G; Vetlitskii, I; Viertel, Gert M; Vivargent, M; Vlachos, S; Völkert, R; Vogel, H; Vogt, H; Vorobev, I; Vorobyov, A A; Vorvolakos, A; Wadhwa, M; Wallraff, W; Wang, J C; Wang, X L; Wang, Z M; Weber, A; Wu, S X; Wynhoff, S; Xu, J; Xu, Z Z; Yang, B Z; Yang, C G; Yao, X Y; Ye, J B; Yeh, S C; You, J M; Zalite, A; Zalite, Yu; Zemp, P; Zeng, Y; Zhang, Z; Zhang, Z P; Zhou, B; Zhou, Y; Zhu, G Y; Zhu, R Y; Zichichi, Antonino; Ziegler, F

    1998-01-01

    Time-dependent ${\\mathrm{B^{0}}\\mbox{-}\\bar{\\mathrm{B}} ^{0}}$ mixing is studied using about two million hadronic Z decays registered by L3 in 1994 and 1995. For this study three techniques are used. Tagging of the b-quark charge at decay time is performed by identifying leptons from semileptonic B decays. The flavour of the b quark at production time is determined from the charge of the lepton in the opposite hemisphere or by using a jet-charge technique. The proper time of the B-particle decay is obtained by reconstructing the production and decay vertices or by a measurement of the lepton impact parameter. The combined result for the frequency of ${\\mathrm{B_d^0}}$ meson oscillations is \\begin{displaymath} {\\Delta m_d} = 0.444 \\pm 0.040 \\ \\mathrm{ps}^{-1}. \\end{displaymath} \\end{abstract} \\end{document}

  5. Development of a metadata schema describing Institutional Repository content objects enhanced by ''LODE-BD'' strategies

    Directory of Open Access Journals (Sweden)

    Iryna Solodovnik

    2013-07-01

    Full Text Available Basato sulle "Linee guida per la creazione e la gestione di metadati nei repository istituzionali” (CRUI, Italia, 2012, sulle "Raccomandazioni LODe BD” (AIMS, 2012 e, sull'esplorazione di altri principi e strategie per lo sviluppo qualitativo dei metadati che rappresentano il contenuto e le proprietà dei contenuti digitali, questo articolo presenta il profilo specifico dei metadati per la descrizione dei dati relativi alle risorse depositate negli archivi istituzionali. Questo profilo è allocato all'interno di uno schema di metadati fornito da termini ben definiti, dalle specifiche di compilazione, dalle strategie di allineamento (mappatura per specifici termini di metadati e dal valore della proprietà che consente ai metadati base di diventare più efficienti nel contesto del controllo d'autorità, più ricchi nei loro profili semantici, più accessibili e utilizzabili in rete per mezzo dei Linked Data. Lo sviluppo e l'implementazione degli schemi di metadati completamente o parzialmente allineati con il paradigma dei Linked Data, fornirà lo scambio tra i differenti metadati, potenziando così la relazione semantica, l'interrogazione del loro contenuto e la loro partecipazione ai Linked Open Data.

  6. Papers of the Braunschweigische Wissenschaftliche Gesellschaft. Vol. LIX; Abhandlungen der Braunschweigischen Wissenschaftlichen Gesellschaft. Bd. LIX

    Energy Technology Data Exchange (ETDEWEB)

    Scheier, Claus-Artur (ed.)

    2008-07-01

    The topic of this symposium is global change and biological invasion. Looking back on earth history to get a rule for the dynamic of changes to be watched today. The science history with contributions on Leibnitz, Euler and Moses Mendelsohn is also presented, and finally presented are contributions on theology and cognition theory. (orig./GL)

  7. Exercises in dental radiology. Vol. 3. Uebungen in zahnaerztlicher Roentgenologie. Bd. 3. Intraorale Roentgendiagnostik

    Energy Technology Data Exchange (ETDEWEB)

    Dixter, C.; Langlais, R.P.; Lichty, G.C.

    1983-01-01

    The book is addressed to paediatric dentists and other dentists who have children among their patients; it presents a survey of normal and pathological development of teeth and surrounding tissues. Imaging errors, eruption problems, anomalies the radiological picture of primary and secondary crowding during eruption, analysis of the deciduous teeth, teleradiography, traumas and temporomandibular diseases are discussed. Each chapter contains questions concerning the interpretation of the radiological findings.

  8. New Observables In the Decay Mode \\bar B_d \\-->\\bar K^{0*} \\ell^+ \\ell^-

    Energy Technology Data Exchange (ETDEWEB)

    Egede, U.; /Imperial Coll., London; Hurth, T.; /CERN /SLAC; Matias, J.; Ramon, M.; /Barcelona, IFAE; Reece, W.; /Imperial Coll., London

    2008-08-07

    We discuss the large set of observables available from the angular distributions of the decay {bar B}{sub d} {yields} {bar K}*{sup 0}{ell}{sup +}{ell}{sup -}. We present a NLO analysis of all observables based on the QCD factorization approach in the low-dilepton mass region and an estimate of {Lambda}/m{sub b} corrections. Moreover, we discuss their sensitivity to new physics. We explore the experimental sensitivities at LHCb (10 fb{sup -1}) and SuperLHCb (100 fb{sup -1}) based on a full-angular fit method and explore the sensitivity to right handed currents. We also show that the previously discussed transversity amplitude A{sub T}{sup (1)} cannot be measured at the LHCb experiment or at future B factory experiments as it requires a measurement of the spin of the final state particles.

  9. Transactions of the Gesellschaft fuer Oekologie. Vol. 22; Verhandlungen der Gesellschaft fuer Oekologie. Bd. 22

    Energy Technology Data Exchange (ETDEWEB)

    Pfadenhauer, J. [ed.; Kappen, L. [ed.; Mahn, E.G. [ed.; Otte, A. [ed.; Plachter, H. [ed.; Seitz, A. [ed.

    1993-12-31

    This conference volume contains 75 contributions on the following major subjects: Extensification in cultivated areas (24); ecological compensation areas (12); revitalization of rivers and lakes and the banks of rivers and lakes (4); ecology of the Alpine region (2); ecology of the tropics (4); population ecology of plants (4); didactics and translation into practice of ecological knowledge (7); theory in ecology (3); independent subjects and other contributions (15). (vhe) [Deutsch] Der vorliegende Tagungsband enthaelt insgesamt 75 Beitraege zu den folgenden Schwerpunktthemen: Extensivierung in der Kulturlandschaft (24); Oekologische Ausgleichsflaechen (12); Revitalisierung von Gewaessern und Uferzonen (4); Oekologie des Alpenraumes (2); Tropenoekologie (4); Populationsoekologie der Pflanzen (4); Didaktik und Umsetzung oekologischer Erkenntnisse (7); Theorie in der Oekologie (3), Freie Themen und andere Beitraege (15). (vhe)

  10. Probing new physics in electroweak penguins through Bd and Bs decays

    Science.gov (United States)

    Hofer, Lars; Scherer, Dominik; Vernazza, Leonardo

    2011-12-01

    An enhanced electroweak penguin amplitude due to the presence of unknown new physics can explain the discrepancies found between theory and experiment in the B → πK decays, in particular in ACP(B- → π0K-) - ACP(bar B0 → π+K-), but the current precision of the theoretical and experimental results does not allow to draw a firm conclusion. We argue that the bar Bs → phiρ0 and bar Bs → phiπ0 decays offer an additional tool to investigate this possibility. These purely isospin-violating decays are dominated by electroweak penguins and we show that in presence of a new physics contribution their branching ratio can be enhanced by about an order of magnitude, without violating any constraints from other hadronic B decays. This makes them very interesting modes for LHCb and future B factories. In [1] we have performed both a model-independent analysis and a study within realistic New Physics models such as a modified-Z0-penguin scenario, a model with an additional Z' boson and the MSSM. In this article we summarise the most important results of our study.

  11. 50 Years ARW jubilee report 2007. Vol. 64; 50 Jahre ARW Jubilaeumsbericht 2007. Bd. 64

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    In the scope of the celebration of the 50th jubilee of the Arbeitsgemeinschaft Rhein-Wasserwerke e.V. (Cologne, Federal Republic of Germany), the following lectures were held: (a) Chronicle of the Arbeitsgemeinschaft Rhein-Wasserwerke (ARW); (b) Sandoz - a lucky chance for ARW? The significance of ARW for the water winning at the Rhine; (c) IKSR quality monitoring - from the beginnings to the new measurement program 2007; (d) 20 Years common activities of ARW and the German Commission for the protection of the Rhine (DK) - main themes and future demands; (e) Specific activities of wastewater investigation of the industry; (f) The advantage of average values; (g) Demands to the future evaluation of monitoring programs; (h) 50 Years investigations of ARW - successes and demands; (i) Quality monitoring during sampling of drinking water - monitoring and topical monitoring.

  12. Research on the airborne SINS/CNS integrated navigation system assisted by BD navigation system

    Science.gov (United States)

    Xie, Mei-lin; Yang, Xiao-xu; Han, Jun-feng; Wei, Yu; Yue, Peng; Deng, Xiao-guo; Huang, Wei

    2016-01-01

    When the star navigation system working during the day, the strong sky background radiation lead to a result that the detect target light is too weak, in the field of view, because of the limitation on the number of the navigation star, usually choose the single star navigation work mode. In order to improve the reliability of the airborne SINS/CNS integrated navigation system, meet the demand of the long-endurance and high precision navigation, use the tight combination way, single star patrol algorithm to get the position and attitude. There exists filtering divergence problem because of the model error and the system measurement noise is uncertain, put forward a new fuzzy adaptive kalman filtering algorithm. Adjust the size of measurement noise to prevent the filter divergence; the positioning accuracy of integrated navigation system can be improved through BeiDou satellite. Without the information of BeiDou satellite, based on the level of the virtual reference, the navigation precision of integrated navigation system can be ensured over a period of time.

  13. Experimental radiotherapy and clinical radiobiology. Vol. 19. Proceedings; Experimentelle Strahlentherapie und Klinische Strahlenbiologie. Bd. 19. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, Michael; Dahm-Daphi, Jochen; Dikomey, Ekkehard; Petersen, Cordula; Rodemann, H. Peter; Zips, Daniel (eds.)

    2010-12-18

    The proceedings include review contributions on radio-oncology, and new radiation technologies and molecular prediction; and poster sessions on the following topics: hypoxia; molecular mechanisms of radiation resistance; molecular targeting; DNA repair; biological imaging; biology of experimental radiations; normal tissue toxicity; modern radiotherapy; tumor hypoxia and metabolic micro milieu; immune system and radiotherapy.

  14. Dicty_cDB: FC-BD08 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available TRSTRSLSTTTTTSSISRSTTTNGCLSTTTRCISRSTRCLSRSTRCISRSTRCI SRSTTNGCI--- ---KIIG*nkrkffffflsmyiiylfkkidirklk*w*kk...STTTNGCLSTTTRCISRSTRCLSRSTRCISRSTRCI SRSTTNGCI--- ---KIIG*nkrkffffflsmyiiylfkkidirklk*w*kkkkfik*nnyfvlfnqykk

  15. Theory of nuclear reactors. Vol. 1. Theorie der Kernreaktoren. Bd. 1. Der stationaere Reaktor

    Energy Technology Data Exchange (ETDEWEB)

    Emendoerfer, D.; Hoecker, K.H.

    1982-01-01

    An introduction is given to the elements of reactor physics and reactor calculation which refers to practice from the present point of view. It is demonstrated to the reader how the reactor characteristics relevant to construction can be calculated from atomic factors by means of neutron transport and diffusion theory; these reactor characteristics are: multiplication factor, power density distribution, burn-up, plutonium build-up, xenon vibrations, short-time behaviour. The interaction between thermo- and fluid-dynamic processes is important for this calculation. On grounds of didactics the crucial point of this book is the establishment and calculation of simple models which give a clear description of all important characteristics of the events. Attempts for more exact simulation by computer are dealt with including typical solutions.

  16. Dicty_cDB: FC-BD13 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available RP11-29P12 on chromosome 9. 40 6e-04 4 AW306469 |AW306469.1 se51b09.y1 Gm-c1017 Glycine max cDNA clone GENOME SYSTEMS...ycine max cDNA clone GENOME SYSTEMS CLONE ID: Gm-c1062-1887 5' similar to TR:Q9S7...1 3 AW394993 |AW394993.1 sh38b07.y1 Gm-c1017 Glycine max cDNA clone GENOME SYSTEMS CLONE ID: Gm-c1017-3950 5...isiae genomic 5', genomic survey sequence. 34 0.002 3 AI759854 |AI759854.1 sb65b12.y1 Gm-c1017 Glycine max cDNA clone GENOME SYSTEMS...40 Q9S740 F14K14.17 PROTEIN. ;, mRNA sequence. 34 0.001 3 AI899992 |AI899992.1 sb97c10.y1 Gm-c1012 Glycine max cDNA clone GENOME SYST

  17. Excercises in diagnostic radiology. Vol. 8. Uebungen in radiologischer Diagnostik. Bd. 8. Notfaelle

    Energy Technology Data Exchange (ETDEWEB)

    Langston, C.S.; Squire, L.F.

    1982-01-01

    Diagnostic radiology in emergency patients as a supplement to anamnesis and examination has gained increasing importance in the last few years. Usually, the physician in charge has only few signs to go by when a patient is sent to radiology. The most frequent signs are pectoral pain, headache, dyspenea, etc. The cases in this book have been selected accordingly. Although the names have been invented the case histories presented have not been greatly changed. The original 'negatives' of the anamnesis are not presented in most cases as they would have taken up too much space. No important information has been omitted. A typical and unusual cases are characterized as such.

  18. Experimental radiotherapy and clinical radiobiology. Vol. 22. Proceedings; Experimentelle Strahlentherapie und Klinische Strahlenbiologie. Bd. 25. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, Michael; Krause, Mechthild [Universitaetsklinikum Technische Univ. Dresden (Germany). Klinik und Poliklinik fuer Strahlentherapie und Radiologie; Cordes, Nils [Universitaetsklinikum Technische Univ. Dresden (Germany). OncoRay - Nationales Zentrum fuer Strahlenforschung in der Radioonkologie; Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany); Petersen, Cordula [Universitaetsklinikum Hamburg-Eppendorf, Hamburg (Germany). Klinik und Poliklinik fuer Strahlentherapie und Radioonkologie; Rodemann, H. Peter [Universitaetsklinikum Tuebingen (Germany). Sektion fuer Strahlenbiologie; Rothkamm, Kai [Universitaetsklinikum Hamburg-Eppendorf, Hamburg (Germany). Lab. fuer Strahlentherapie und Experimentelle Radioonkologie; Zips, Daniel (ed.) [Tuebingen Univ. (Germany). Universitaetsklinik fuer Radioonkologie

    2016-05-01

    The proceedings of the 25th symposium on experimental radiotherapy and clinical radiobiology include papers on the following issues: radiotherapy individualization based on imaging; pre-clinic imaging and new experimental methods; methods and models, micromilieu and metabolism, combined therapy; secondary tumors following radiotherapy; radiogenic effects in normal tissue; resistance mechanism of tumors and normal tissue; personalized radio-oncology - which biological data are needed; pre-clinic and personalized radio-oncology; biomarkers - pre-clinic and translational; translational examinations for personalized radio-oncology.

  19. Electron microscopic imaging of surfaces. Vol. 14. Beitraege zur elektronenmikroskopischen Direktabbildung von Oberflaechen. Bd. 14

    Energy Technology Data Exchange (ETDEWEB)

    Pfefferkorn, G.

    1981-01-01

    The volume contains 85 contributions to the following topics: micro area analysis, material investigations, electron scattering and diffraction, crystal defects, SEM in biology and medicine. Separate abstracts were prepared for 26 papers in this volume.

  20. Electrical engineering fundamentals. Vol. 1. 2. ed.; Allgemeine Elektrotechnik. Bd. 1

    Energy Technology Data Exchange (ETDEWEB)

    Seidel, H.U.; Wagner, E. [Technische Hochschule Ilmenau (Germany)

    1999-07-01

    This textbook provides fundamental knowledge in electrical engineering, i.e. physical laws, methodology, energy conversion elements, modules and componentry. The fundamentals of electrical engineering are presented, from the calculation of steady phenomena to a.c. circuits and to wave propagation along power lines. The book can also serve as a textbook for students at all levels. [German] Dieses Lehrbuch vermittelt allgemeines, studienuebergreifendes Grundlagenwissen des Elektrotechnikers. Dabei werden in enger Anlehnung an die physikalischen Grundgesetze der Elektrotechnik sowohl die grundlegenden Arbeitsmethoden als auch wesentliche Energieumwandlungsprozesse, Bauelemente und Baugruppen behandelt. Die Autoren behandeln die Grundgebiete der Elektrotechnik von der Berechnung stationaerer Vorgaenge ueber Wechselstromschaltungen bis zur Wellenausbreitung laengs Leitungen. Die didaktische Aufbereitung sowohl bezueglich der vorausgesetzten mathematischen Kenntnisse als auch in der gewaehlten Abfolge der Stoffdarstellung entsprechend den im Studiengang fortschreitenden mathematischen und physikalischen Faehigkeiten macht dieses Lehrbuch auch fuer Studenten von Beginn des Studiums an zu einem nuetzlichen Hilfsmittel. In die Darstellung sind die langjaehrigen Erfahrungen der Autoren zu den Grundlagen der Elektrotechnik eingegangen. (orig.)

  1. Electrical engineering fundamentals. Vol. 2. 2. ed.; Allgemeine Elektrotechnik. Bd. 2

    Energy Technology Data Exchange (ETDEWEB)

    Seidel, H.U.; Wagner, E. [Technische Hochschule Ilmenau (Germany)

    2000-07-01

    This interdisciplinary textbook provides fundamental knowledge of electrical engineering, from the calculation of steady processes to a.c. circuits and wave propagation along power lines. [German] Dieses moderne Lehrbuch vermittelt allgemeines, studienganguebergreifendes Grundlagenwissen des Elektrotechnikers. Dabei werden in enger Anlehnung an die physikalen Grundgesetze der Elektrotechnik sowohl die grundlegenden Arbeitsmethoden als auch wesentliche Energieumwandlungsprozesse, Bauelemente und Baugruppen vorgestellt. Die Autoren behandeln die Grundgebiete der Elektrotechnik von der Berechnung stationaerer Vorgaenge ueber Wechselstromschaltungen bis zur Wellenausbreitung laengs Leitungen. (orig.)

  2. Experimental radiotherapy and clinical radiobiology. Vol. 18. Proceedings; Experimentelle Strahlentherapie und Klinische Strahlenbiologie. Bd. 18. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, Michael; Dahm-Daphi, Jochen; Dikomey, Ekkehard; Petersen, Cordula; Rodemann, H. Peter; Zips, Daniel (eds.)

    2009-07-15

    The proceedings on experimental radiotherapy and clinical radiobiology contain two review articles (prediction of normal tissue reactions after radiotherapy, ?H2AX foci as a marker for DNA double-strand breaks) and 34 contributions to the following topics: Hypoxia and molecular mechanisms of radiation resistance; biological imaging of the tumor micromilieu; DNA repair, genomic instability and carcerogenesis; molecular factors of radiation resistance; actual controversial discussion on possible irradiation caused metastasis risk enhancement; EGFR inhibition and irradiation; biology of experimental radiation/ normal tissue toxicity.

  3. Anonyme, "L’autrier cuidai aber druda" (BdT 461.146

    Directory of Open Access Journals (Sweden)

    Dominique Billy

    2015-08-01

    Full Text Available "L’autrier cuidai aber druda" is one of a small group of texts written in a mixed linguistic variety that has both French and Occitan features and which includes the lais "Markiol" and "Nompar," that are moreover transmitted by the same French manuscript, the so-called Chansonnier du Roi, among a collection of troubadour poems, most of which are also copied in a mixed variety. The accommodation of this kind of text in trouvère songbooks would seem to point to a specific tradition in which troubadour songs would circulate not in their original language, but in a gallicized version, which allowed for the prestige of the source language to be retained as well as maintaining the most important formal features of the poem: versification and sophisticated rhyme schemes. This tradition seems to have encouraged some trouvères – who remain anonymous – to compose poetry directly in this mixed variety, in forms that tend to be characteristic of trouvère poetry. The present text is a lyric adaptation of a parody of Ovid’s "Amores", known as "De Vetula", the interpretation of which has given rise to different opinions, which will be discussed here along with a closer study of the language.

  4. Raimbaut de Vaqueiras, “Domna, tant vos ai prejada” (BdT 392.7

    Directory of Open Access Journals (Sweden)

    Gilda Caiti-Russo

    2009-12-01

    Full Text Available This paper will attempt to read Raimbaut de Vaqueiras’ ‘contrasto’ from the viewpoint of its explicit addressees: the late twelfth-century imperial nobility of north-western Italy, as embodied by the Malaspina family. The text’s distinctive bilingualism thus assumes social and political significance since it pits the claims of the feudal aristocracy of the hinterland against the power of the Genoese bankers and merchants. The dialectical relationship of the two sides involved, played out by the voices of the jongleur and the Genoese lady, is nevertheless also literary: Raimbaut appears to match popular poetry, poetry which is «non regulata» as Dante would later call it, against a century of courtly Occitan poetry distinguished by an extremely formal tradition. A carnivalesque dimension is thus present in the reciprocal illumination of the two poetic voices: if popular poetry is unregulated despite its expressive qualities, troubadour poetry is confined, by means of the parody of the genre of the ‘salut’, to topics far-removed from reality. Raimbaut’s aim then is to restructure trobar by going back to the beginning: to the Count of Poitiers and his political and cultural act of inventing a secular poetry of aristocratic inspiration and in the vernacular. A ‘male’ poetry that will be formulated by the surprising gap at the end of the poem.

  5. Micro-Eukaryote Diversity in Freshwater Ponds That Harbor the Amphibian Pathogen "Batrachochytrium Dendrobatidis" ("Bd")

    Science.gov (United States)

    Lauer, Antje; McConnel, Lonnie; Singh, Navdeep

    2012-01-01

    We designed a microbiology project that fully engaged undergraduate biology students, high school students, and their teachers in a summer research program as part of the Research Education Vitalizing Science University Program conducted at California State University Bakersfield. Modern molecular biological methods and microscopy were used to…

  6. Measurement of the Ratios of Branching Fractions B(Bs -> Ds pi pi pi) / B(Bd -> Dd pi pi pi) and B(Bs -> Ds pi) / B(Bd -> Dd pi)

    Energy Technology Data Exchange (ETDEWEB)

    Abulencia, A.; /Illinois U., Urbana; Adelman, J.; /Chicago U.; Affolder, T.; /UC, Santa Barbara; Akimoto, T.; /Tsukuba U.; Albrow, M.G.; /Fermilab; Ambrose, D.; /Fermilab; Amerio, S.; /Padua U.; Amidei, D.; /Michigan U.; Anastassov, A.; /Rutgers U., Piscataway; Anikeev, K.; /Fermilab; Annovi, A.; /Frascati /Taiwan, Inst. Phys.

    2006-10-01

    Using 355 pb{sup -1} of data collected by the CDF II detector in p{bar p} collisions at {radical}s = 1.96 TeV at the Fermilab Tevatron, they study the fully reconstructed hadronic decays B{sub (s)}{sup 0} {yields} D{sub (s)}{sup -}{pi}{sup +} and B{sub (s)}{sup 0} {yields} D{sub (s)}{sup -} {pi}{sup +}{pi}{sup +}{pi}{sup -}. They present the first measurement of the ratio of branching fractions {Beta}(B{sub s}{sup 0} {yields} D{sub s}{sup -}{pi}{sup +}{pi}{sup +}{pi}{sup -})/{Beta}(B{sup 0} {yields} D{sup -} {pi}{sup +}{pi}{sup +}{pi}{sup -}) = 1.05 {+-} 0.10(stat.) {+-} 0.22(syst.). They also update their measurement of {Beta}(B{sub s}{sup 0} {yields} D{sub s}{sup -} {pi}{sup +})/{Beta}(B{sup 0} {yields} D{sup -} {pi}{sup +}) to 1.13 {+-} 0.08(stat.) {+-} 0.23(syst.) improving the statistical uncertainty by more than a factor of two. They find {Beta}(B{sub s}{sup 0} {yields} D{sub s}{sup -} {pi}{sup +}) = [3.8 {+-} 0.3(stat.) {+-} 1.3(syst.)] x 10{sup -3} and {Beta}(B{sub s}{sup 0} {yields} D{sub s}{sup -} {pi}{sup +}{pi}{sup +}{pi}{sup -}) = [8.4 {+-} 0.8(stat.) {+-} 3.2(syst.)] x 10{sup -3}.

  7. Handbook on criticality. Vol. 1. Criticality and nuclear safety; Handbuch zur Kritikalitaet. Bd. 1. Kritikalitaet und nukleare Sicherheit

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-04-15

    This handbook was prepared primarily with the aim to provide information to experts in industry, authorities or research facilities engaged in criticality-safety-related problems that will allow an adequate and rapid assessment of criticality safety issues already in the planning and preparation of nuclear facilities. However, it is not the intention of the authors of the handbook to offer ready solutions to complex problems of nuclear safety. Such questions have to remain subject to an in-depth analysis and assessment to be carried out by dedicated criticality safety experts. Compared with the previous edition dated December 1998, this handbook has been further revised and supplemented. The proven basic structure of the handbook remains unchanged. The handbook follows in some ways similar criticality handbooks or instructions published in the USA, UK, France, Japan and the former Soviet Union. The expedient use of the information given in this handbook requires a fundamental understanding of criticality and the terminology of nuclear safety. In Vol. 1, ''Criticality and Nuclear Safety'', therefore, first the most important terms and fundamentals are introduced and explained. Subsequently, experimental techniques and calculation methods for evaluating criticality problems are presented. The following chapters of Vol. 1 deal i. a. with the effect of neutron reflectors and absorbers, neutron interaction, measuring methods for criticality, and organisational safety measures and provide an overview of criticality-relevant operational experience and of criticality accidents and their potential hazardous impact. Vol. 2 parts 1 and 2 finally compile criticality parameters in graphical and tabular form. The individual graph sheets are provided with an initially explained set of identifiers, to allow the quick finding of the information of current interest. Part 1 includes criticality parameters for systems with {sup 235}U as fissile material, while part 2 deals with systems comprising {sup 233}U, plutonium and higher actinides.

  8. 30th international Vienna motor symposium. Vol. 2. Second day; 30. Internationales Wiener Motorensymposium. Bd. 2. Zweiter Tag

    Energy Technology Data Exchange (ETDEWEB)

    Lenz, Hans Peter (comp.)

    2009-07-01

    This two-volume report makes the presentations of the 30{sup th} International Vienna Motor Symposium (May 7-8, 2009) available to a wider audience. The objective of the Vienna Motor Symposia is to examine current topics of particular interest. Among others, the work examines the above mentioned topics. Included is a CD-ROM containing the presentations in their original form and in English translation. Edited by Univ.-Prof. Dr. techn. Dipl.-Ing. H.P. Lenz, VDI, Chairman of the OeVK (Austrian Society of Automotive Engineers, Vienna). (orig.)

  9. 33{sup rd} international Vienna motor symposium. Vol. 1. First day; 33. internationales Wiener Motorensymposium. Bd. 1. Erster Tag

    Energy Technology Data Exchange (ETDEWEB)

    Lenz, Hans Peter (comp.)

    2012-11-01

    This two-volume report makes the presentations of the 33{sup rd} International Vienna Motor Symposium (April 26-27, 2012) available to a wider audience. The objective of the Vienna Motor Symposia is to examine current topics of particular interest. Among others, the work examines the above mentioned topics. Included is a CD-ROM containing the presentations in their original form and in English translation. Edited by Univ.-Prof. Dr. techn. Dipl.-Ing. H.P. Lenz, VDI, Chairman of the OeVK (Austrian Society of Automotive Engineers, Vienna).

  10. 26. international Vienna engine symposium. Vol. 1. First day; 26. Internationales Wiener Motorensymposium. Bd. 1. Erster Tag

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2005-07-01

    Papers of the above symposium are presented in two volumes. The Vienna Engine Symposium is a forum for discussing current trends in internal combustion engines. Subjects: New gasoline and diesel engines; From conventional to hybrid drives; Electronic key technologies; Emission reduction today; Supercharged DI gasoline engines; DI diesel engines; Exhaust treatment; Simulation; Transmission; Acoustics; The future of mobility. (orig.)

  11. 32{sup nd} international Vienna motor symposium. Vol. 2. Second day; 32. internationales Wiener Motorensymposium. Bd. 2. Zweiter Tag

    Energy Technology Data Exchange (ETDEWEB)

    Lenz, Hans Peter (comp.)

    2011-07-01

    This two-volume report makes the presentations of the 32nd International Vienna Motor Symposium (5th-6th April, 2011) available to a wider audience. The objective of the Vienna Motor Symposia is to examine current topics of particular interest in a concise manner. Among others, the work examines the following new developments: new otto machines, new diesel engines, offroad and high performance engines, exhaust gas aftertreatment, injection systems for Otto and Diesel engines. - Included is a CD-ROM containing the presentations in their original form, with colour illustrations and English text.

  12. 30th international Vienna motor symposium. Vol. 1. First day; 30. Internationales Wiener Motorensymposium. Bd. 1. Erster Tag

    Energy Technology Data Exchange (ETDEWEB)

    Lenz, Hans Peter (comp.)

    2009-07-01

    This two-volume report makes the presentations of the 30{sup th} International Vienna Motor Symposium (May 7-8, 2009) available to a wider audience. The objective of the Vienna Motor Symposia is to examine current topics of particular interest. Among others, the work examines the above mentioned topics. Included is a CD-ROM containing the presentations in their original form and in English translation. Edited by Univ.-Prof. Dr. techn. Dipl.-Ing. H.P. Lenz, VDI, Chairman of the OeVK (Austrian Society of Automotive Engineers, Vienna). (orig.)

  13. 34{sup th} international Vienna motor symposium. Vol. 2. Second day; 34. Internationales Wiener Motorensymposium. Bd. 2. Zweiter Tag

    Energy Technology Data Exchange (ETDEWEB)

    Lenz, Hans Peter (comp.)

    2013-08-01

    This two-volume report makes the presentations of the 34th International Vienna Motor Symposium (April 25-26, 2013) available to a wider audience. The objective of the Vienna Motor Symposia is to examine current topics of particular interest. Among others, the work examines the above mentioned topics. Included is a CD-ROM containing the presentations in their original form and in English translation. Edited by Univ.-Prof. Dr. techn. Dipl.-Ing. H. P. Lenz, VDI, Chairman of the OeVK (Austrian Society of Automotive Engineers, Vienna).

  14. 27th international Vienna engine symposium. Vol. 1. First day; 27. Internationales Wiener Motorensymposium. Bd. 1. Erster Tag

    Energy Technology Data Exchange (ETDEWEB)

    Lenz, H.P. (comp.)

    2006-07-01

    Abstract: This two-volume report makes the presentations of the 27{sup th} International Vienna Motor Symposium (April 27-28, 2006) available to a wider audience. The objective of the Vienna Motor Symposia is to examine current topics of particular interest in a concise manner. Among others, the work examines the following new developments: Effects of engine emissions on climate, new gasoline and diesel engines, diesel sound engineering, emissions reduction, hybrids, fuel injection, fuels, components, control systems, future perspectives. Included is a CD-ROM containing the presentations in their original form, with colour illustrations and English text. - Edited by Prof. Dr. H.P. Lenz, VDI, Chairman of the OeVK (Austrian Society of Automotive Engineers, Vienna). (orig.)

  15. 28. international Vienna motor symposium. Vol. 2. Second day; 28. Internationales Wiener Motorensymposium. Bd. 2. Zweiter Tag

    Energy Technology Data Exchange (ETDEWEB)

    Lenz, H.P. (comp.)

    2007-07-01

    This two-volume report makes the presentations of the 28{sup th} International Vienna Motor Symposium (April 26,-27, 2007) available to a wider audience. The objective of the Vienna Motor Symposia is to examine current topics of particular interest in a concise manner. Among others, the work examines the following new developments: diesel injection and combustion; acoustics and sound design, materials and components; engine management,; exhaust gas aftertreatment; supercharging; hybrid drive systems. Included is a CD-ROM containing the presentations in their original form, with colour illustrations and English text. - Edited by Univ.-Prof. Dr. techn. Dipl.-Ing. H.P. Lenz VDI, Chairman of the OeKV (Austrian Society of Automotive Engineers, Vienna). (orig.)

  16. 34{sup th} international Vienna motor symposium. Vol. 1. First day; 34. Internationales Wiener Motorensymposium. Bd. 1. Erster Tag

    Energy Technology Data Exchange (ETDEWEB)

    Lenz, Hans Peter (comp.)

    2013-08-01

    This two-volume report makes the presentations of the 34th International Vienna Motor Symposium (April 25-26, 2013) available to a wider audience. The objective of the Vienna Motor Symposia is to examine current topics of particular interest. Among others, the work examines the above mentioned topics. Included is a CD-ROM containing the presentations in their original form and in English translation. Edited by Univ.-Prof. Dr. techn. Dipl.-Ing. H. P. Lenz, VDI, Chairman of the OeVK (Austrian Society of Automotive Engineers, Vienna).

  17. 32{sup nd} international Vienna motor symposium. Vol. 1. First day; 32. internationales Wiener Motorensymposium. Bd. 1. Erster Tag

    Energy Technology Data Exchange (ETDEWEB)

    Lenz, Hans Peter (comp.)

    2011-07-01

    This two-volume report makes the presentations of the 32nd International Vienna Motor Symposium (5th-6th April, 2011) available to a wider audience. The objective of the Vienna Motor Symposia is to examine current topics of particular interest in a concise manner. Among others, the work examines the following new developments: new otto machines, new diesel engines, offroad and high performance engines, exhaust gas aftertreatment, injection systems for Otto and Diesel engines. - Included is a CD-ROM containing the presentations in their original form, with colour illustrations and English text.

  18. 29th international Vienna motor symposium. Vol. 1. First day; 29. Internationales Wiener Motorensymposium. Bd. 1. Erster Tag

    Energy Technology Data Exchange (ETDEWEB)

    Lenz, H.P. (comp.)

    2008-07-01

    This two-volume report makes the presentations of the 29{sup th} International Vienna Motor Symposium (April 24-25, 2008) available to a wider audience. The objective of the Vienna Motor Symposia is to examine current topics of particular interest in a concise manner. Among others, the work examines the following new developments: injection and combustion; sound design; materials and components; engine management; exhaust gas aftertreatment. - Included is a CD-ROM containing the presentations in their original form, with colour illustrations and English text. (orig.)

  19. 31th international Vienna motor symposium. Vol. 2. Second day; 31. Internationales Wiener Motorensymposium. Bd. 2. Zweiter Tag

    Energy Technology Data Exchange (ETDEWEB)

    Lenz, Hans Peter (comp.)

    2010-07-01

    These two volumes contain all the lectures delivered at the 31{sup st} International Vienna Motor Symposium, which took place on 29{sup th} and 30{sup th} April, 2010. In these lectures pre-eminent automotive engineers presented various aspects of state-of-the-art of engine technology. Further to this, I would like to express my heartfelt thanks to all of these individuals, as well as the companies they represent, for their contributions to our conference. All lectures on the enclosed CD are available in their original version as well as in English translation. The word-search facility at www.oevk.at - the Austrian Society of Automotive Engineers (OEVK) website - allows a direct access to the titles of lectures, together with information on all the authors and companies that have participated in the International Vienna Motor Symposia since 1999 (German since 1981). The publications list - which is to be found on the following page - provides an anthology of all lectures delivered at the International Vienna Motor Symposia between 1979 and 2010. It is intended to provide a broader public with further information on the topics and subject matter dealt with by these conferences. The 32{sup nd} International Vienna Motor Symposium is to take place on the 5{sup th} and 6{sup th} Mai, 2011, and may I take this early opportunity to extend you an invitation. (orig.)

  20. 31th international Vienna motor symposium. Vol. 1. First day; 31. Internationales Wiener Motorensymposium. Bd. 1. Erster Tag

    Energy Technology Data Exchange (ETDEWEB)

    Lenz, Hans Peter (comp.)

    2010-07-01

    These two volumes contain all the lectures delivered at the 31{sup st} International Vienna Motor Symposium, which took place on 29{sup th} and 30{sup th} April, 2010. In these lectures pre-eminent automotive engineers presented various aspects of state-of-the-art of engine technology. Further to this, I would like to express my heartfelt thanks to all of these individuals, as well as the companies they represent, for their contributions to our conference. All lectures on the enclosed CD are available in their original version as well as in English translation. The word-search facility at www.oevk.at - the Austrian Society of Automotive Engineers (OEVK) website - allows a direct access to the titles of lectures, together with information on all the authors and companies that have participated in the International Vienna Motor Symposia since 1999 (German since 1981). The publications list - which is to be found on the following page - provides an anthology of all lectures delivered at the International Vienna Motor Symposia between 1979 and 2010. It is intended to provide a broader public with further information on the topics and subject matter dealt with by these conferences. The 32{sup nd} International Vienna Motor Symposium is to take place on the 5{sup th} and 6{sup th} Mai, 2011, and may I take this early opportunity to extend you an invitation. (orig.)

  1. 24. international Vienna engine symposium. Vol. 1. First day; 24. Internationales Wiener Motorensymposium. Bd. 1. Erster Tag

    Energy Technology Data Exchange (ETDEWEB)

    Lenz, H.P. (comp.)

    2003-07-01

    This two-volume publication contains the papers of the 24th International Vienna Engine Symposium of 15/16 May 2003. Among the subjects discussed are: New gasoline engines, DI gasoline engines and diesel engines, new high-performance engines, future engines and transmission systems; Diesel soot, structure and health hazards, diesel exhaust treatment, gasoline DI ignition, hydrogen, fuel injection and variable valve control; future co-operations, creativity and trademarks. [German] In diesem zweibaendigen Werk werden die Vortraege des 24. Internationalen Wiener Motorensymposiums vom 15./16. Mai 2003 wiedergegeben und damit einer breiten Oeffentlichkeit zugaenglich gemacht. Aufgabe der Wiener Motorensymposien ist es, kurzfristig und komprimiert Themen von besonderer Aktualitaet auf dem Gebiet des Verbrennungsmotors zu behandeln. Dieses Werk befasst sich u.a. mit folgenden neuen Entwicklungen: Motoren und Getriebe: neue Otto-, Otto-Direkteinspritzungs- und Diesel-Motoren; neue Hoechstleistungsmotoren; zukuenftige Motoren und Getriebe; neue Erkenntnisse auf den Gebieten: Dieselruss: Struktur und Gesundheitsgefaehrdung, Diesel-Abgasnachbehandlung, Otto-Direkteinspritzungs-Zuendung, Wasserstoff, Einspritzung und variable Ventilsteuerung; Zukunftsperspektiven: Allianzen, Kreativitaet und Marken. - Herausgeber: Univ.-Prof. Dr. techn. Dipl.-Ing. H.P. Lenz, Vorsitzender des Oesterreichischen Vereins fuer Kraftfahrzeugtechnik (OeVK), Wien. (orig.)

  2. 33{sup rd} international Vienna motor symposium. Vol. 2. Second day; 33. internationales Wiener Motorensymposium. Bd. 2. Zweiter Tag

    Energy Technology Data Exchange (ETDEWEB)

    Lenz, Hans Peter (comp.)

    2012-11-01

    This two-volume report makes the presentations of the 33{sup rd} International Vienna Motor Symposium (April 26-27, 2012) available to a wider audience. The objective of the Vienna Motor Symposia is to examine current topics of particular interest. Among others, the work examines the above mentioned topics. Included is a CD-ROM containing the presentations in their original form and in English translation. Edited by Univ.-Prof. Dr. techn. Dipl.-Ing. H.P. Lenz, VDI, Chairman of the OeVK (Austrian Society of Automotive Engineers, Vienna).

  3. 26. international Vienna engine symposium. Vol. 2. Second day; 26. Internationales Wiener Motorensymposium. Bd. 2. Zweiter Tag

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2005-07-01

    Papers of the above symposium are presented in two volumes. The Vienna Engine Symposium is a forum for discussing current trends in internal combustion engines. Subjects: New gasoline and diesel engines; From conventional to hybrid drives; Electronic key technologies; Emission reduction today; Supercharged DI gasoline engines; DI diesel engines; Exhaust treatment; Simulation; Transmission; Acoustics; The future of mobility. (orig.)

  4. 29. international Vienna motor symposium. Vol. 2. Second day; 29. Internationales Wiener Motorensymposium. Bd. 2. Zweiter Tag

    Energy Technology Data Exchange (ETDEWEB)

    Lenz, H.P. (comp.)

    2008-07-01

    This two-volume report makes the presentations of the 29{sup th} International Vienna Motor Symposium (April 24-25, 2008) available to a wider audience. The objective of the Vienna Motor Symposia is to examine current topics of particular interest in a concise manner. Among others, the work examines the following new developments: injection and combustion; sound design; materials and components; engine management; exhaust gas aftertreatment. - Included is a CD-ROM containing the presentations in their original form, with colour illustrations and English text. (orig.)

  5. 27. international Vienna engine symposium. Vol. 2. Second day; 27. Internationales Wiener Motorensymposium. Bd. 2. Zweiter Tag

    Energy Technology Data Exchange (ETDEWEB)

    Lenz, H.P. (comp.)

    2006-07-01

    Abstract: This two-volume report makes the presentations of the 27{sup th} International Vienna Motor Symposium (April 27-28, 2006) available to a wider audience. The objective of the Vienna Motor Symposia is to examine current topics of particular interest in a concise manner. Among others, the work examines the following new developments: Effects of engine emissions on climate, new gasoline and diesel engines, diesel sound engineering, emissions reduction, hybrids, fuel injection, fuels, components, control systems, future perspectives. Included is a CD-ROM containing the presentations in their original form, with colour illustrations and English text. - Edited by Prof. Dr. H.P. Lenz, VDI, Chairman of the OeVK (Austrian Society of Automotive Engineers, Vienna). (orig.)

  6. 28th international Vienna motor symposium. Vol. 1. First day; 28. Internationales Wiener Motorensymposium. Bd. 1. Erster Tag

    Energy Technology Data Exchange (ETDEWEB)

    Lenz, H.P. (comp.)

    2007-07-01

    This two-volume report makes the presentations of the 28{sup th} International Vienna Motor Symposium (April 26,-27, 2007) available to a wider audience. The objective of the Vienna Motor Symposia is to examine current topics of particular interest in a concise manner. Among others, the work examines the following new developments: diesel injection and combustion; acoustics and sound design, materials and components; engine management,; exhaust gas aftertreatment; supercharging; hybrid drive systems. Included is a CD-ROM containing the presentations in their original form, with colour illustrations and English text. - Edited by Univ.-Prof. Dr. techn. Dipl.-Ing. H.P. Lenz VDI, Chairman of the OeKV (Austrian Society of Automotive Engineers, Vienna). (orig.)

  7. MIRD Commentary: Proposed Name for a Dosimetry Unit Applicable to Deterministic Biological Effects-The Barendsen (Bd)

    Energy Technology Data Exchange (ETDEWEB)

    Sgouros, George; Howell, R. W.; Bolch, Wesley E.; Fisher, Darrell R.

    2009-03-02

    The fundamental physical quantity for relating all biologic effects to radiation exposure is the absorbed dose, the energy imparted per unit mass of tissue. Absorbed dose is expressed in units of joules per kilogram (J/kg) and is given the special name gray (Gy). Exposure to ionizing radiation may cause both deterministic and stochastic biologic effects. To account for the relative effect per unit absorbed dose that has been observed for different types of radiation, the International Commission on Radiological Protection (ICRP) has established radiation weighting factors for stochastic effects. The product of absorbed dose in Gy and the radiation weighting factor is defined as the equivalent dose. Equivalent dose values are designated by a special named unit, the sievert (Sv). Unlike the situation for stochastic effects, no well-defined formalism and associated special named quantities have been widely adopted for deterministic effects. The therapeutic application of radionuclides and, specifically, -particle emitters in nuclear medicine has brought to the forefront the need for a well-defined dosimetry formalism applicable to deterministic effects that is accompanied by corresponding special named quantities. This commentary reviews recent proposals related to this issue and concludes with a recommendation to establish a new named quantity.

  8. Search for Bs --> mu+mu- and Bd --> mu+mu- Decays with 2fb-1 of ppbar Collisions

    Energy Technology Data Exchange (ETDEWEB)

    Collaboration, CDF; Aaltonen, T.

    2007-12-01

    The authors have performed a search for B{sub s}{sup 0} {yields} {mu}{sup +}{mu}{sup -} and B{sup 0} {yields} {mu}{sup +}{mu}{sup -} decays in p{bar p} collisions at {radical}s = 1.96 TeV using 2 fb{sup -1} of integrated luminosity collected by the CDF II detector at the Fermilab Tevatron Collider. The observed number of B{sub s}{sup 0} and B{sup 0} candidates is consistent with background expectations. The resulting upper limits on the branching fractions are {Beta}(B{sub s}{sup 0} {yields} {mu}{sup +}{mu}{sup -}) < 5.8 x 10{sup -8} and {Beta}(B{sup 0} {yields} {mu}{sup +}{mu}{sup -}) < 1.8 x 10{sup -8} at 95% C.L.

  9. 76 FR 62669 - Airworthiness Directives; Bombardier, Inc. Model BD-100-1A10 (Challenger 300) Airplanes

    Science.gov (United States)

    2011-10-11

    ... receive about this proposed AD. Discussion The Transport Canada Civil Aviation (TCCA), which is the... Transport Canada Civil Aviation (TCCA) Airworthiness Directive CF-2011-05, dated March 24, 2011;...

  10. Comparative Evaluation of the BD Phoenix Yeast ID Panel and Remel RapID Yeast Plus System for Yeast Identification

    OpenAIRE

    Michelle L. Grant; Shobha Parajuli; Raquel Deleon-Gonsalves; Raghava Potula; Truant, Allan L.

    2016-01-01

    Becton Dickinson Phoenix Yeast ID Panel was compared to the Remel RapID Yeast Plus System using 150 recent clinical yeast isolates and the API 20C AUX system to resolve discrepant results. The concordance rate between the Yeast ID Panel and the RapID Yeast Plus System (without arbitration) was 93.3% with 97.3% (146/150) and 95.3% (143/150) of the isolates correctly identified by the Becton Dickinson Phoenix and the Remel RapID, respectively, with arbitration.

  11. Raimbaut de Vaqueiras (?), “Altas undas que venez suz la mar” (BdT 392.5a)

    OpenAIRE

    Giuseppe Tavani

    2008-01-01

    The article proposes a new authorship for Altas undas que venez suz la mar, a poem attributed by ms. Sg to Raimbaut de Vaqueiras. This authorship has long been debated by scholars. Altas undas is almost without a doubt a specimen of cantiga de amigo, a Galician-Portuguese lyric genre which flourished in the 13th century, slightly after Raimbaut’s death. This leads to some crucial problems. Is Raimbaut the inventor of this genre? Did he imitate a Galician-Portuguese model? If so, did Galician-...

  12. Falquet de Romans, “Ma bella dompna, per vos dei esser gais” (BdT 156.8)

    OpenAIRE

    Paolo Di Luca

    2010-01-01

    “Ma bella dompna per vos dei esser gais” by Falquet de Romans has been taken for a courtly song for a long time. However, the poem’s metrical form is derived directly from that of the epic, as illustrated by the use of monorhymed ‘décasyllabes’ with non-systematic epic caesura and the presence of a ‘petit vers’ at the end of each stanza. The poem may thus be defined as stanzaic but not lyric because its versification is that of the chanson de geste and its music must be that of an epic chant....

  13. Raimbaut de Vaqueiras (?, “Altas undas que venez suz la mar” (BdT 392.5a

    Directory of Open Access Journals (Sweden)

    Giuseppe Tavani

    2008-12-01

    Full Text Available The article proposes a new authorship for Altas undas que venez suz la mar, a poem attributed by ms. Sg to Raimbaut de Vaqueiras. This authorship has long been debated by scholars. Altas undas is almost without a doubt a specimen of cantiga de amigo, a Galician-Portuguese lyric genre which flourished in the 13th century, slightly after Raimbaut’s death. This leads to some crucial problems. Is Raimbaut the inventor of this genre? Did he imitate a Galician-Portuguese model? If so, did Galician-Portuguese lyric begin earlier than is generally acknowledged? Did Raimbaut draw inspiration from another extravagant lyric genre, the French chanson de toile, to compose Altas undas? The critical history of the poem is summarized by Tavani, who concludes that Altas undas may be attributed to Cerveri de Girona, a 13th century Catalan troubadour.

  14. Falquet de Romans, “Ma bella dompna, per vos dei esser gais” (BdT 156.8

    Directory of Open Access Journals (Sweden)

    Paolo Di Luca

    2010-08-01

    Full Text Available “Ma bella dompna per vos dei esser gais” by Falquet de Romans has been taken for a courtly song for a long time. However, the poem’s metrical form is derived directly from that of the epic, as illustrated by the use of monorhymed ‘décasyllabes’ with non-systematic epic caesura and the presence of a ‘petit vers’ at the end of each stanza. The poem may thus be defined as stanzaic but not lyric because its versification is that of the chanson de geste and its music must be that of an epic chant. Moreover, its content reflects the rhetorical structure of the ‘salut d’amor’, an epistolary genre in which the lover sends a letter to his lady asking her to respond to his love. Thus, “Ma bella dompna” should be considered a formal hybrid between ‘salut d’amor’ and ‘chanson de geste’; in this sense it is to be compared to those few compositions of an epistolary nature that employ epic form, such as Raimbaut de Vaqueiras’ famous letter to the Marquis Boniface of Monferrato, which is probably the prototype of this poetic experiment, along with two pairs of ‘laisses’ exchanged between Gui de Cavaillon and Bertran Folco d’Avignon.

  15. Salt Lake City Area Integrated Projects Electric Power Marketing. Draft environmental impact statement: Volume 4, Appendixes B-D

    Energy Technology Data Exchange (ETDEWEB)

    1994-02-01

    The Salt Lake City Area Office of the Western Area Power Administration (Western) markets electricity produced at hydroelectric facilities operated by the Bureau of Reclamation. The facilities are known collectively as the Salt Lake City Area Integrated Projects (SLCA/IP) and include dams equipped for power generation on the Green, Gunnison, Rio Grande, and Colorado rivers and on Deer and Plateau creeks in the states of Wyoming, Utah, Colorado, Arizona, and New Mexico. Of these facilities, only the Glen Canyon Unit, the Flaming Gorge Unit, and the Aspinall Unit (which includes Blue Mesa, Morrow Point, and Crystal dams;) are influenced by Western power scheduling and transmission decisions. The EIS alternatives, called commitment-level alternatives, reflect combinations of capacity and energy that would feasibly and reasonably fulfill Westerns firm power marketing responsibilities, needs, and statutory obligations. The viability of these alternatives relates directly to the combination of generation capability of the SLCA/IP with energy purchases and interchange. The economic and natural resource assessments in this environmental impact statement (EIS) include an analysis of commitment-level alternatives. Impacts of the no-action alternative are also assessed. Supply options, which include combinations of electrical power purchases and hydropower operational scenarios reflecting different operations of the dams, are also assessed. The EIS evaluates the impacts of these scenarios relative to socioeconomics, air resources, water resources, ecological resources, cultural resources, land use, recreation, and visual resources.

  16. Search for the decays B$_{d}^{0}$ --> $\\gamma\\gamma$ and B$_{s}^{0}$ --> $\\gamma\\gamma$

    CERN Document Server

    Acciarri, M; Adriani, O; Aguilar-Benítez, M; Ahlen, S P; Alpat, B; Alcaraz, J; Allaby, James V; Aloisio, A; Alverson, G; Alviggi, M G; Ambrosi, G; Anderhub, H; Andreev, V P; Angelescu, T; Antreasyan, D; Arefev, A; Azemoon, T; Aziz, T; Bagnaia, P; Baksay, L; Ball, R C; Banerjee, S; Banicz, K; Barillère, R; Barone, L; Bartalini, P; Baschirotto, A; Basile, M; Battiston, R; Bay, A; Becattini, F; Becker, U; Behner, F; Bencze, G L; Berdugo, J; Berges, P; Bertucci, B; Betev, B L; Biasini, M; Biland, A; Bilei, G M; Bizzarri, R; Blaising, J J; Bobbink, Gerjan J; Böck, R K; Böhm, A; Borgia, B; Boucham, A; Bourilkov, D; Bourquin, Maurice; Boutigny, D; Brambilla, Elena; Branson, J G; Brigljevic, V; Brock, I C; Buijs, A; Bujak, A T; Burger, J D; Burger, W J; Burgos, C; Busenitz, J K; Buytenhuijs, A O; Cai, X D; Capell, M; Cara Romeo, G; Caria, M; Carlino, G; Cartacci, A M; Casaus, J; Castellini, G; Castello, R; Cavallari, F; Cavallo, N; Cecchi, C; Cerrada-Canales, M; Cesaroni, F; Chamizo-Llatas, M; Chan, A; Chang, Y H; Chaturvedi, U K; Chemarin, M; Chen, A; Chen, C; Chen, G; Chen, G M; Chen, H F; Chen, H S; Chen, M; Chiefari, G; Chien, C Y; Choi, M T; Cifarelli, Luisa; Cindolo, F; Civinini, C; Clare, I; Clare, R; Coan, T E; Cohn, H O; Coignet, G; Colijn, A P; Colino, N; Commichau, V; Costantini, S; Cotorobai, F; de la Cruz, B; Dai, T S; D'Alessandro, R; De Asmundis, R; De Boeck, H; Degré, A; Deiters, K; Dénes, E; Denes, P; De Notaristefani, F; DiBitonto, Daryl; Diemoz, M; Van Dierendonck, D N; Di Lodovico, F; Dionisi, C; Dittmar, Michael; Dominguez, A; Doria, A; Dorne, I; Dova, M T; Drago, E; Duchesneau, D; Duinker, P; Durán, I; Dutta, S; Easo, S; Efremenko, Yu V; El-Mamouni, H; Engler, A; Eppling, F J; Erné, F C; Ernenwein, J P; Extermann, Pierre; Fabbretti, R; Fabre, M; Faccini, R; Falciano, S; Favara, A; Fay, J; Felcini, Marta; Ferguson, T; Fernández, D; Fernández, G; Ferroni, F; Fesefeldt, H S; Fiandrini, E; Field, J H; Filthaut, Frank; Fisher, P H; Forconi, G; Fredj, L; Freudenreich, Klaus; Gailloud, M; Galaktionov, Yu; Ganguli, S N; García-Abia, P; Gau, S S; Gentile, S; Gerald, J; Gheordanescu, N; Giagu, S; Goldfarb, S; Goldstein, J; Gong, Z F; González, E; Gougas, Andreas; Goujon, D; Gratta, Giorgio; Grünewald, M W; Gupta, V K; Gurtu, A; Gustafson, H R; Gutay, L J; Hartmann, B; Hasan, A; He, J T; Hebbeker, T; Hervé, A; Hilgers, K; Van Hoek, W C; Hofer, H; Hoorani, H; Hou, S R; Hu, G; Ilyas, M M; Innocente, Vincenzo; Janssen, H; Jin, B N; Jones, L W; de Jong, P; Josa-Mutuberria, I; Kasser, A; Khan, R A; Kamyshkov, Yu A; Kapinos, P; Kapustinsky, J S; Karyotakis, Yu; Kaur, M; Kienzle-Focacci, M N; Kim, D; Kim, J K; Kim, S C; Kim, Y G; Kinnison, W W; Kirkby, A; Kirkby, D; Kirkby, Jasper; Kittel, E W; Klimentov, A; König, A C; Koffeman, E; Kornadt, O; Koutsenko, V F; Koulbardis, A; Krämer, R W; Kramer, T; Krenz, W; Kuijten, H; Kunin, A; Ladrón de Guevara, P; Landi, G; Lapoint, C; Lassila-Perini, K M; Laurikainen, P; Lebeau, M; Lebedev, A; Lebrun, P; Lecomte, P; Lecoq, P; Le Coultre, P; Lee Jae Sik; Lee, K Y; Leggett, C; Le Goff, J M; Leiste, R; Lenti, M; Leonardi, E; Levchenko, P M; Li Chuan; Lieb, E H; Lin, W T; Linde, Frank L; Lindemann, B; Lista, L; Liu, Z A; Lohmann, W; Longo, E; Lu, W; Lü, Y S; Lübelsmeyer, K; Luci, C; Luckey, D; Ludovici, L; Luminari, L; Lustermann, W; Ma Wen Gan; Macchiolo, A; Maity, M; Malgeri, L; Malinin, A; Maña, C; Mangla, S; Maolinbay, M; Marchesini, P A; Marin, A; Martin, J P; Marzano, F; Massaro, G G G; Mazumdar, K; McNally, D; Mele, S; Merola, L; Meschini, M; Metzger, W J; Mi, Y; Mihul, A; Van Mil, A J W; Mirabelli, G; Mnich, J; Möller, M; Monteleoni, B; Moore, R; Morand, R; Morganti, S; Mount, R; Muheim, F; Müller, S; Nagy, E; Nahn, S; Napolitano, M; Nessi-Tedaldi, F; Newman, H; Nippe, A; Nowak, H; Organtini, G; Ostonen, R; Pandoulas, D; Paoletti, S; Paolucci, P; Pascale, G; Passaleva, G; Patricelli, S; Paul, T; Pauluzzi, M; Paus, C; Pauss, Felicitas; Pei, Y J; Pensotti, S; Perret-Gallix, D; Petrak, S; Pevsner, A; Piccolo, D; Pieri, M; Pinto, J C; Piroué, P A; Pistolesi, E; Plyaskin, V; Pohl, M; Pozhidaev, V; Postema, H; Produit, N; Raghavan, R; Rahal-Callot, G; Rancoita, P G; Rattaggi, M; Raven, G; Razis, P A; Read, K; Redaelli, M; Ren, D; Rescigno, M; Reucroft, S; Ricker, A; Riemann, S; Riemers, B C; Riles, K; Rind, O; Ro, S; Robohm, A; Rodin, J; Rodríguez-Calonge, F J; Roe, B P; Röhner, M; Röhner, S; Romero, L; Rosier-Lees, S; Rosselet, P; Van Rossum, W; Roth, S; Rubio, Juan Antonio; Rykaczewski, H; Salicio, J; Salicio, J M; Sánchez, E; Santocchia, A; Sarakinos, M E; Sarkar, S; Sassowsky, M; Sauvage, G; Schäfer, C; Shchegelskii, V; Schmitz, D; Schmitz, P; Schneegans, M; Schöneich, B; Scholz, N; Schopper, Herwig Franz; Schotanus, D J; Schulte, R; Schultze, K; Schwenke, J; Schwering, G; Sciacca, C; Seiler, P G; Sens, Johannes C; Servoli, L; Shevchenko, S; Shivarov, N; Shoutko, V; Shukla, J; Shumilov, E; Son, D; Sopczak, André; Soulimov, V; Smith, B; Spickermann, T; Spillantini, P; Steuer, M; Stickland, D P; Sticozzi, F; Stone, H; Stoyanov, B; Strauch, K; Sudhakar, K; Sultanov, G G; Sun, L Z; Susinno, G F; Suter, H; Swain, J D; Tang, X W; Tauscher, Ludwig; Taylor, L; Ting, Samuel C C; Ting, S M; Toker, O; Tonisch, F; Tonutti, M; Tonwar, S C; Tóth, J; Tsaregorodtsev, A Yu; Tsipolitis, G; Tully, C; Tuchscherer, H; Ulbricht, J; Urbàn, L; Uwer, U; Valente, E; Van de Walle, R T; Vetlitskii, I; Viertel, Gert M; Vivargent, M; Völkert, R; Vogel, H; Vogt, H; Vorobev, I; Vorobyov, A A; Vuilleumier, L; Wadhwa, M; Wallraff, W; Wang, J C; Wang, X L; Wang, Y F; Wang, Z M; Weber, A; Weill, R; Willmott, C; Wittgenstein, F; Wu, S X; Wynhoff, S; Xu, J; Xu, Z Z; Yang, B Z; Yang, C G; Yao, X Y; Ye, J B; Yeh, S C; You, J M; Zaccardelli, C; Zalite, A; Zemp, P; Zeng, J Y; Zeng, Y; Zhang, Z; Zhang, Z P; Zhou, B; Zhou, G J; Zhou, J F; Zhou, Y; Zhu, G Y; Zhu, R Y; Zichichi, Antonino; Van der Zwaan, B C C

    1995-01-01

    A search for the decays \\Bdsgg in 2.95 million hadronic \\rm Z decays has been performed using the L3 detector at LEP. No candidates are found in the signal region and upper limits have been set on the branching ratios: \\Brdgg < 3.9\\times 10^{-5} and \\Brsgg < 14.8\\times 10^{-5} at 90\\% CL. These are the first limits set on these exclusive rare decays.

  17. Achieving a production goal of 1 million B/D of coal liquids by 1990. [Impediments and constraints

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Charles; LaRosa, Dr., P. J.; Coles, E. T.; Fein, H. L.; Petros, J. J.; Iyer, R. S.; Merritt, R. T.

    1980-03-01

    Under this contract, Bechtel analyzed the resource requirements and reviewed major obstacles to the daily production of several million barrels of synthetic coal liquids. Further, the study sought to identify the industry infrastructure needed to support the commercial readiness of the coal liquefaction process. A selected list of critical resource items and their domestic/international availability was developed and examined, and the impact of their supply on the various synthetic coal liquids programs was evaluated. The study approach was to develop representative, or generic, direct and indirect coal liquefaction conceptual designs from available technology and costs data. The generic processes were to employ technology that would be considered commercial by the mid- or late-1980s. The size of the generic construction mobilization was considered reasonable at the outset of the program. The product slate was directed toward unrefined liquid fuels rather than diesel oil or gasoline. The generic processes were to use a wide range of coals to permit siting in most coal-producing regions across the country. Because of the dearth of conceptual design data in the literature, Bechtel developed generic plant designs by using in-house design expertise. Bechtel assumed that because it is first generation technology, the indirect process will be used at the outset of the liquids program, and the direct process will be introduced two to four years later as a second generation technology. The products of either of these processes will be limited to boiler fuels and/or other liquid products which require further upgrading. Cost estimates were developed from equipment lists, as well as material and labor estimates, which enabled the determination of an order-of-magnitude cost estimate and target plant construction schedule for both processes.

  18. Multimedia Archiving: Videotape, Compact Disc (CD), Digital Versatile Disc (DVD), and Blu-Ray Disc (BD) Media

    Science.gov (United States)

    2010-02-01

    single-layer disc with a cyanine dye layer for recording. With a 4.7 GB capacity, DVD-R provides a high- end, write-once recording media for...GB 4.7 GB (single side) *available 2001-2 Recording Medium Molded Pits Cyanine Dye Phase Change High Reflectivity Phase Change Phase Change...Azo is dark blue. Cyanine can be various shades of green or blue depending on the ultraviolet (UV) stabilizers that are added. The type of

  19. Measurement of CP violation effects in $B_{d}^{0} \\to J/\\psi K_{s}^{0}$ in ATLAS

    CERN Document Server

    Damet, J

    2000-01-01

    Direct measurements of the angles of the Cabibbo-Kobayashi-Maskawa (CKM) unitarity triangle will be possible at the B-factories now being commissioned. The physics potential of the ATLAS experiment which will be a general purpose experiment at LHC to determine CP violation parameters from measurement of neutral B-meson decays is discussed. An estimation of the error in sin2 beta is presented for three years of running (corresponding to 30fb/sup -1/) based on reconstruction of the decay channel B/sub d//sup 0/ to J/ psi K/sub S //sup 0/ using two tagging methods. To determine the asymmetry that is due to CP violation, the asymmetry due to different production probabilities of B/sub d//sup 0/ and B/sub d//sup 0/ in pp collisions has to be subtracted from the measured asymmetry. The accuracy with which this production asymmetry can be measured has been estimated using the two control channels B/sub d//sup 0/ to J/ psi K/sup 0/* and B/sub d//sup 0/ to J/ psi K/sup +/. (7 refs).

  20. 75 FR 16646 - Airworthiness Directives; Bombardier, Inc. Model BD-100-1A10 (Challenger 300) Airplanes

    Science.gov (United States)

    2010-04-02

    ... during a production flight test where the proximity-sensor electronic unit (PSEU) failed. This resulted in unannunciated loss of: Wheel brakes below 10 knots; Thrust reverser; Nose wheel steering; and Auto... incident during a production flight test where the proximity-sensor electronic unit (PSEU) failed....

  1. International scientific conference biogas science 2009. Vol. 3. Poster; Internationale Wissenschaftstagung Biogas Science 2009. Bd. 3. Poster

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-12-15

    Within the international conference of the Bavarian State Research Center for Agriculture (Munich, Federal Republic of Germany) at 2nd to 4th December, 2009, in Erding (Federal Republic of Germany), the following lectures were held: (1) Experiments with weed seeds in the silage and fermentation process for biogas (P.R. Westermann et al.); (2) Documentation and production of quality silage from the harvest to the storage (K. Kellner); (3) Energy losses during the storage of co-substrates and possibilities of avoidance (H. Lindorfer et al.); (4) Two harvests a year for the biomass production? (J. Moeser et al.); (5) Effects of limonene on anaerobic co-digestion of citrus waste (M.B. Ruiz Fuertes et al.); (6) Biogas from genetically modified Bt-maize - potentials and limitations (U. Schoebinger et al.); (7) Green rye as a winter intercrop for the generation of biogas (E. Sticksel et al.); (8) Potential of energy yield and climate effects by means of biogas generation from vegetable coupled products (W. Stinner et al.); (9) The evaluation of the potential of gas generation from renewable raw materials (F. Weissbach); (10) Production of biogas from grass silage: Investigations of process stability (D. Andrade et al.); (11) Optimising biological desulphurisation with the addition of humic substances (U. Gayh et al.); (12) Thermophilic digestion of cellulose - investigation of the inhibitory state (K. Galkowska et al.); (13) In-situ methane enhancement system using differential solubility of biogas (J.J. Ho Kang); (14) Development of a new biogas process for the efficient utilization of renewable raw materials on thermophilic basis (C. Martin-Perez et al.); (15) Determination of a maximal space pollution of a mono fermentation of maize in a one-step or two-step system at 40 C and at 50 C in laboratory scale (M. Reuter et al.); (16) Anaerobic digestion of rye silage by a two-phase biogas process (S. Zielonka et al.); (17) Improvement of the efficiency of agricultural biogas plants by mashing the co-ferments (P. Krampe); (18) Exhaust air purification after a biogas pressurized water purification - process and first practical experiences - (E. Luthardt); (19) Recycle plants for fish culture in combination with biogas generation - possibilities and problems (H. Wedekind); (20) The influence of antibiotics on running processes in the biogas production (G. Henkelmann et al.); (21) Selection and analysis of microbial cultures for efficient biomass conversion to methane (T. Koellmeier et al.); (22) Hydrolytic enzymes for the increase of the gas yield in the biogas production (V. Pelenc et al.); (23) Dynamics of microbial community for anaerobic digestion from a synthetic model substrate for maize silage under influence of trace elements (H. Pobeheim et al.); (24) Isolation and characterization of methane bacteria from biogas plants (K. Seyfarth et al.); (25) Enhancement of biogas production by addition of hemicellulolytic bacteria immobilised on activated zeolite IPUS meth-max {sup registered} (S. Weiss et al.); (26) Visualization of methane emissions (M. Brand); (27) Process control of an anaerobic hydrolysis-acidogenesis phase of a two-stage fermenter system treating maize silage (F. Liu et al.); (27) Laboratory services and quality assurance in the biogas production (K. Meyer zu Koecker et al.); (28) Identification of parameters for a non-linear model for biogas production (F. Scholwin et al.); (29) FOS/TAC derivation, methods, application and practical value (E. Voss et al.); (29) Investigations of the prediction of characteristic values of the anaerobic degradation process in biogas fermenters by means of NIR spectroscopy (C. Krapf et al.); (30) Economic sensitivity analysis of the biogas process based on neuronal grids (F. Bechstein et al.); (31) Mass flow analysis of the biogas production chain harvest-silage-fermentation (D. Banemann et al.); (32) Assessing the overall efficiency of Bavarian pilot biogas plants (D. Djatkov et al.); (33) Energy balance and CO{sub 2} balance for silage maize for biogas generation from cultivation to power feeding (B. Eder et al.); (34) Harvest logistic of biomass - Evaluation and optimisation (M. Strobl); (35) Experiences and regulations for the use of Off farm source materials as co-substrates for farm based digesters in the province of Ontario, Canada (D. Hilborn et al.).

  2. Giraut de Borneil, “Ben cove, pus ja bayssa·l ram” (BdT 242.25

    Directory of Open Access Journals (Sweden)

    Pietro G. Beltrami

    2009-01-01

    Full Text Available This paper will offer a revision, with a translation and commentary, of the text of “Ben cove, pus ja baissa·l ram” by Giraut de Borneil, with a new examination of the manuscript tradition after the monographic editions by Adolf Kolsen and Ruth Verity Sharman. In particular the paper will offer a new reading of l. 20, transmitted only by Chansonnier a, while the other manuscripts have a lacuna that seems to have been crudely corrected by Sg. The interpretation of “e leis s’embla, que a miralh” as ‘and she, who holds a mirror, is elusive’ restores an image of the lady filled with pride on seeing her own beauty reflected in a mirror that is also in Raimbaut d’Aurenga and Pons de Capduoill. In the Introduction the text is interpreted as an example of two different aspects of Giraut’s poetry, expressed through two different voices in the text, the author’s ‘self’ and the lover’s ‘self’. The former, who speaks in the first stanza, gives importance to his aiming for excellence; the latter, who speaks in the following stanzas, presents contents and forms belonging to a discourse on love. Finally, the point is made that where the two parts meet, at l. 9 “E per ma guerreira cui am” ‘and for my enemy whom I love’, the text is of great poetic intensity.

  3. Differential diagnosis in pediatric radiology. Vol. 1. Skull, spine, skeleton; Differentialdiagnostik in der paediatrischen Radiologie. Bd. 1. Schaedel, Wirbelsaeule, Skelett

    Energy Technology Data Exchange (ETDEWEB)

    Ebel, K.D. [ed.; Willich, E. [ed.; Richter, E. [ed.; Benz-Bohm, G.; Bliesener-Harzheim, J.A.; Ebel, K.D.; Oestreich, A.E.; Reinwein, H.; Schaper, J.; Schumacher, R.; Stoever, B.

    1995-06-01

    The book presents in-depth material covering the full scope of tasks and problems of differential diagnostic radiology in children. The particular approach chosen by the authors provides information that will solve even the most difficult cases, guiding the reader on his way from radiographic findings to appropriate diagnosis. All radiographic findings have been characterized and classified and put into a tabulated system relating them to the relevant differential diagnosis. The system of reference adopted specifies a given lesion or disease by reference to the most significant diagnostic keywords obtained from anamnesis, clinical data, and further diagnostic evaluation. The tentative diagnosis is taken as the basis for further specification illustrated by the characteristic X-ray pictures and full-text descriptions. Almost all diagnoses are accompanied by a comprehensive image documentation obtained by all currently available imaging methods. (MG) [Deutsch] Das vorliegende Buch gibt einen kompletten Ueberblick ueeber die gesamte Bandbreite der Differentialdiagnostik in der Paediatrischen Radiologie und soll so auch in schwierigen Faeellen den Weg vom Roentgensymptom zur Diagnose ermoeglichen. Alle relevanten Roentgensymptome werden systematisch charakterisiert und die entsprechenden Differentialdiagnosen tabellarisch zusammengestellt. Jede Erkrankung wird durch Verweise auf die wichtigsten differentialdiagnostischen Stichworte aus Anamnese, Klinik und weiterfuehrende Diagnostik naeher eingegrenzt. Ausgehend von der Verdachtsdiagnose werden wegweisende Roentgenbefunde in Wort und Bild dargestellt. Fast alle erwaehnten Befunde werden durch Abbildungen unter Beruecksichtigung aller moderner bildgebenden Verfahren dokumentiert. (MG)

  4. Peire Bremon Ricas Novas, “Rics pres, ferms e sobeirans” (BdT 330.15a

    Directory of Open Access Journals (Sweden)

    Paolo Di Luca

    2008-03-01

    Full Text Available This article provides a new critical edition and a commentary of Peire Bremon Ricas Novas’s “Rics pres, ferms e sobeirans”, a courtly love song composed between 1228 and 1257 and dedicated to Audiart del Baux. Built as a eulogy of the lady, the song focuses on the central theme of the moral and material ‘ricor’ (richness of the latter. The complexity of the metrical form, which displays a systematic use of the technique of ‘rim derivatiu’, is paralleled by the semantic obscurity of a number of verses and hapaxes, all discussed in the commentary. Stanzas III and IV show echoes of Jaufre Rudel’s “amor de lonh”, since the lover-poet declares that the distance and the ethnical difference between himself and the lady are abolished by the strength of his feelings. The use of ethnonyms in stanza IV is closely examined: the lover-poet reveals that he loves a Castilian lady who looks like a ‘Serrana’ (the name of an Iberian population, admitting that he would like her even if she were Catalan or Syrian. These references to the lady’s ethnical origins are puzzling: they can be read as a calembour with burlesque overtones, as well as a climax aiming to define the real provenance of the lady or as a rhetorical device to underline that courtly love does not know any kind of boundary.

  5. Wooden windows and doors. Vol. 2. Construction, connections, surfaces, energy conservation; Holzfenster und -tueren. Bd. 2. Konstruktion, Anschluesse, Oberflaechen, Energieeinsparung

    Energy Technology Data Exchange (ETDEWEB)

    Arnold, Ulrich; Huckfeldt, Tobias; Wenk, Hans-Joachim (eds.)

    2012-07-01

    Vol. II supplements and complements Vol. I with much additional information. While Vol. I focused exclusively on wooden windows, Vol. II goes into wooden doors, frames, connections, armature technology, folding and rolling shutters, skylights, wooden replacement parts, replacement parts made of other materials, and energy conservation. Other subjects like armatures, glazing, damage, repair, restoration, maintenance and regulations are presented in more detail. [German] Als Band II ergaenzt und komplettiert das Buch den ersten Band ''Holzfenster'' mit zahlreichen flankierenden Themenbereichen. Waehrend sich Band I ausschliesslich auf Holzfenster konzentriert, erschliesst Band II neue Bereiche, wie Holztueren, Rahmenkonstruktionen, Anschluesse, Beschlagtechnik, Fenster- und Rolllaeden, Dachflaechenfenster, Vollholzergaenzungen, Holzersatzmaterialien oder Energieeinsparung. Weitere Themen, wie Beschlaege, Verglasungen, Schaeden, Sanierung, Restaurierung, Wartung und Regelwerke, werden vertieft und ergaenzt.

  6. Guglielmo di Poitiers, “Ab la dolchor del temps novel” (BdT 183.1

    Directory of Open Access Journals (Sweden)

    Francesca Gambino

    2010-11-01

    Full Text Available This paper will put forward some possible new interpretations for selected passages in “Ab la douzor del temps novel” by William of Aquitaine. The term ‘vers’, for example, has always been paraphrased in different ways, but its primary meaning might be that provided by the naturalistic context: in the spring birds twitter among the branches, they produce a ‘verse’. Thus the literal meaning of ‘vers’ could be that of ‘a characteristic sound produced by the vocal organs of a particular animal (mainly a bird’. As for l. 15, instead of the traditional image of the hawthorn branch ‘tremblan’ (‘trembling’ on the tree, the alternative reading entrenan (the branch ‘stands firmly on the tree’, ‘resists the elements’ is preferred, which could well be a lectio difficilior. The paper will end by providing a commentary to the text. The edition used is Eusebi, with some corrections.

  7. 75 FR 27406 - Airworthiness Directives; Bombardier, Inc. Model BD-100-1A10 (Challenger 300) Airplanes

    Science.gov (United States)

    2010-05-17

    ... Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant economic impact, positive or... America Code 21 and 25: Air conditioning and Equipment/Furnishings, respectively. Reason (e) The mandatory... days after the effective date of this AD, revise the Airworthiness Limitations section of...

  8. BMBF status seminar: Bodies of landfills. Vol. 1. Conference report; BMBF-Statusseminar: Deponiekoerper. Bd. 1. Tagungsband

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    This conference report contains the lectures presented at the BMBF status seminar on the cooperative project ``Bodies of landfills``, which took place at Wuppertal on 25th and 26th April 1995. The cooperative project was started in autumn 1993 and studies the long-term behaviour of wastes deposited at landfills in general. Inorganic and municipal wastes are studied separately. (orig./SR) [Deutsch] Der vorliegende Tagungsband enthaelt die Vortraege des BMBF-Statusseminars zum Verbundvorhaben `Deponiekoerper` vom 25. und 26. April 1995 in Wuppertal. Das Verbundvorhaben `Deponiekoerper` wurde im Herbst 1993 begonnen und befasst sich ganz generell mit dem langfristigen Deponieverhalten von Abfaellen. Es ist unterteilt in die Untersuchung von anorganischen Abfaellen und von Siedlungsabfaellen. (orig./SR)

  9. Peire de Blai, “En est son fas chansoneta novelha” (BdT 328.1

    Directory of Open Access Journals (Sweden)

    Giuseppe Tavani

    2010-07-01

    Full Text Available This particular text, defined by its author as a “chansoneta novelha”, is attributed by C to Uc Brunenc and by M to Peire de Blai (Peire de Brau in CReg. It is no masterpiece, but within the troubadour corpus figures as an interesting example, from the viewpoint of technique, of an unusual and complex enlacement of riche rhymes. At the same time it is a unique example of an almost perfect application of the rules of ‘capfinitio’, used here as a linking of verses and stanzas (‘capfinitio per bordos’ and ‘per coblas’. For a long time the poem received no critical attention, then a few years ago it was edited twice almost simultaneously: once by the present author and again by Paolo Gresti, who quite rightly rejected the attribution to Uc Brunenc. This article will offer a new edition of the text based on both manuscripts, but also closely following the structural principles intended by the poet (who most certainly is the Peire de Blai indicated by M. Furthermore, it will examine the questions raised by the chansoneta’s particular position in M, with a view of providing a ‘material’ reassessment of the chansonnier and of describing the possible circumstances in which it was compiled, the period in which it was assembled and then recopied – by a single hand – at a later date than is generally believed.

  10. Blacasset, “Se·l mals d’amor m’auzi ni m’es noisens” (BdT 96.10a; Pujol, “Dieus es amors e verais salvamens” (BdT 386.2; Alaisina ~ Carenza, “Na Carenza al bel cors avenenç” (BdT 12.1 = 108.1

    Directory of Open Access Journals (Sweden)

    Paolo Di Luca

    2012-09-01

    Full Text Available This paper provides a new critical edition of “Se·l mals d’amor m’auzi ni m’es noisens” by Blacasset and “Dieus es amors e verais salvamens by Pujol”. These two poets discuss a topic that is entirely new to Occitan lyric poetry: two young women about to enter a convent. While Blacasset expresses sadness about their choice of life in a convent, using elements of the funeral lament, Pujol praises it and believes it to be the only remedy for the corruption of the world. The tenso between women “Na Carenza al bel cors avenenç” seems to be conceived as a parody of this lyric debate: in the dialogue Alaisina and Yselda, who have doubts about becoming mothers, ask Na Carenza whether it is better to stay virgins or to marry; the latter advises them, in cryptic terms that are difficult to interpret, to become nuns, thereby gaining a husband (God but not children. I will suggest that the question of female authorship for this text be reconsidered, while proposing a new interpretation in the light of the lively debate in the medieval period about the suitability and prerogatives of virginity.

  11. Cross-sectional environmental study comparing two highly polluted areas in Germany (Bitterfeld and Hettstedt) with a control region; Umweltmedizinische Untersuchungen im Raum Bitterfeld, im Raum Hettstedt und einem Vergleichsgebiet 1992-2000. Bd. 1: Textband. Bd. 2: Publikationen. Bd. 3: Untersuchungsdokumente und Frageboegen. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Heinrich, J.; Frye, C.; Hoelscher, B.; Meyer, I.; Pitz, M.; Cyrys, J.; Schneller, H.; Wjst, M.; Wichmann, H.E.

    2001-10-01

    The aim of the environmental epidemiologic study was to determine possible negative effects on the health of children in the very polluted areas of Bitterfeld and Hettstedt in comparison to the less polluted areas of Anhalt-Zerbst (Eastern Germany). The time changes of the health parameters were recorded along with the running redevelopments during the time period of 6 years. The study design consisted of three repeated regional cross sectional studies in 1992/93, 1995/96 and 1998/99. In all, there was information of 7.611 questionnaires to be analysed (participation rate: 89%, 75% and 75%). Children living in the most polluted area of Hettstedt had a noticeable higher risk for non allergic respiratory diseases and symptoms compared to children living in the control area of Anhalt-Zerbst. During the time of the examinations in 1992 till 1999 a clear statistically significant decrease in the prevalences of these restrictions of health could be shown. Children without indoor pollutants in their homes profited most by the improvement of ambient air quality. The better lung function (FVC, FEV{sub 1}) between 1992 and 1999 underlines the improvement of the respiratory health. Children living in both polluted ares have allergies more often (physician's diagnosis, symptoms, allergy specific antibodies). The incidence of asthma, the bronchial hyperreactivity and atopic exzema increased, the prevalence of rhinitis and allergic sensitization did not increase. The body burden with lead and cadmium was higher in children living in polluted areas, but it decreased during the period of observation. In 1997, however, the lead concentration in blood increased a little, parallel to the higher lead concentration in settled dust in Hettstedt at that time. (orig.) [German] Ziel der umweltepidemiologischen Studie war es, moegliche gesundheitliche Beeitraechtigungen von Kindern in den Belastungsgebieten Bitterfeld und Hettstedt i. Vgl. zu dem wenig belasteten Gebiet Anhalt-Zerbst zu ermitteln. Darueber hinaus wurden die zeitlichen Veraenderungen der Gesundheitsparameter begleitend zu den laufenden Sanierungsmassnahmen ueber den Zeitraum von 6 Jahren erfasst. Das Studiendesign bestand aus 3 wiederholten regionalen Querschnittsuntersuchungen in den Jahren 1992/93, 1995/96 und 1998/99. Insgesamt lagen Informationen von 7611 Frageboegen zur Auswertung vor (Beteiligungsrate: 89%, 75% bzw. 75%). Fuer die Belastungsregion Hettstedt waren deutlich hoehere Risiken fuer nicht allergische respiratorische Erkrankungen und Symptome im Vergleich zu Kindern des Kontrollgebietes Anhalt-Zerbst nachweisbar. Waehrend des Untersuchungszeitraumes 1992-1999 zeigte sich eine deutlich statistisch signifikante Abnahme der Praevalenz dieser gesundheitlichen Einschraenkungen, Kinder ohne Exposition mit Innenraumschadstoffen im haeuslichen Bereich profitieren von der Verbesserung der Aussenluftbelastung am meisten. Fuer die Verbesserung der Atemwegsgesundheit sprachen auch bessere Lungenfunktionswerte (FVC, FEV{sub 1}) im Laufe des Beobachtungszeitraumes 1992-1999. Kinder aus den beiden Belastungsregionen hatten haeufiger Allergien (Arztdiagnose, Symptome, allergenspezifischer Antikoerper-Nachweis). Die Haeufigkeit des Asthmas, der bronchialen Hyperreaktivitaet und der Neurodermitis nahm zu; die Praevalenz des Heuschnupfens und der allergischen Sensibilisierung nicht. Die korporale Belastung mit Blei und Cadmium war bei Kindern in den belasteten Regionen erhoeht, nahm aber im Verlauf des Beobachtungszeitraumes ab. Allerdings folgten gestiegenen Bleigehalten im Sedimentationsstaub in Hettstedt im Jahre 1997 leicht gestiegene Blutbleikonzentrationen. (orig.)

  12. Bertran Carbonel, "Cor, diguas me per cal razo" (BdT 82.9; Id., "Un sirventes de vil razo" (BdT 82.18; Id., "S’ieu anc nulh tems chantiei alegramen" (BdT 82.15

    Directory of Open Access Journals (Sweden)

    Oriana Scarpati

    2014-11-01

    Full Text Available In three poems of Bertran Carbonel (a fictive tenso between Lover and Heart, a sirventes, and a planh an unknown person is referred to by the initials «P.G.». In the tenso, this mysterious person figures as the impartial judge of the tenso itself; in the sirventes he is bitterly blamed; in the planh he is mentioned as the object of the lament. On the basis of a metrical, rhetorical and stylistic analysis, the present article aims to demonstrate that these three poems are to be interpreted as progymnasmata, and that, although several scholars have assumed that the reference is to the troubadour Peire Guilhem, no real person is actually hidden under the fictive persona «P.G.» In the article a new critical edition of each poem is also provided.

  13. Utilizando las Matemáticas para resolver problemas de Acústica de Salas

    Directory of Open Access Journals (Sweden)

    Anna Vidal Meló

    2014-03-01

    Full Text Available En este artículo se muestra cómo un alumno puede abordar problemas de acústica de salas ya en primer curso de Grado, con el soporte de las asignaturas de Matemáticas. De este modo, el alumno, encuentra una aplicabilidad directa de los conociminetos adquiridos en asignaturas en asignaturas de Matemáticas en su futuro entorno laboral. Este proyecto se ubica en el Grado de Ingenieria de Sistemas de Telecomunicación, Sonido e Imagn de la Escula Politécnica Superior de Gandia de la Universidad Politécnica de Valéncia.

  14. Cumulated energy consumption - fabrication of cast iron pieces. Vol. 1: Methods of evaluation and analysis of foundries. Vol. 2: Energy consumption of metal cutting processes. Vol. 3: Development of a model for material and energy consumption analysis in casting processes. Final report; Kumulierter Energieaufwand - Gussteilfertigung. Bd. 1. Teilthema: Methodik der Auswertung und Analyse von Giessereien. Bd. 2. Teilthema: Energieaufwand in der spanabhebenden Teilefertigung. Bd. 3. Teilthema: Entwicklung eines Modells zur Stoff- und Energiemengenanalyse fuer die Herstellung von Gussteilen. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Ketscher, N.; Herfurth, K.; Kademann, R.; Wohlgemuth, H.; Huppertz, A.

    1999-07-01

    Development of materials, energy and carbon dioxide balances, acquisition and recording of data on casting and metal cutting processes, with selected examples of the 9 participating partners of the casting industry. [German] Erarbeitung von Stoff-, Energie- und CO{sub 2}-Bilanzen, Erfassung und Ermittlung von Daten fuer die Formgebung durch Giessen und die spangebende Bearbeitung an ausgewaehlten Beispielen der 9 beteiligten Firmen der Giessereiindustrie. (orig.)

  15. Increased Intrasubject Variability in Response Time in Youths with Bipolar Disorder and At-Risk Family Members

    Science.gov (United States)

    Brotman, Melissa A.; Rooney, Melissa H.; Skup, Martha; Pine, Daniel S.; Leibenluft, Ellen

    2009-01-01

    Intrasubject variability in response time (ISV-RT) was higher in youths with bipolar disorder (BD) and those with first-degree relatives with BD compared to youths without BD. ISV-RT may be a risk marker for BD.

  16. Energy saving in houses. Seminar of Zentrale Informationsstelle Umweltberatung Bayern, Vol. 19; Energiesparen rund ums Haus. Seminarband der Zentralen Informationsstelle Umweltberatung Bayern. Bd. 19

    Energy Technology Data Exchange (ETDEWEB)

    Stroh, K.; Behling, G; Koller, U.; Lattner, A. (eds.)

    2002-02-01

    Contents: Information on energy conservation and state funds, Energy management at communal level, eco-balance of power generation; The new Energy Conservation Ordinance; Energy conservation in domestic buildings; Low-consumption power supply systems; Potential savings resulting from consumption patterns; Eco-balances and preventive cost. [German] Referenten aus wissenschaftlichen und behoerdlichen Institutionen informierten ueber aktuelle Erkenntnisse zum Energiesparen in oeffentlichen und privaten Gebaeuden. Dabei wurden folgende Themen behandelt: - Informationen ueber Energiesparen und Foerderprogramme - Energiemanagement fuer Kommunen, Oekobilanz der Stromerzeugung - Die neue Energieeinsparverordnung - Energiesparen in Wohngebaeuden - Sparsame Energieversorgungssysteme - Verhaltensbedingte Einsparpotenziale - Oekobilanzen und Vermeidungskosten. (orig.)

  17. 13 CFR 124.502 - How does an agency offer a procurement to SBA for award through the 8(a) BD program?

    Science.gov (United States)

    2010-01-01

    ... be awarded, such as firm fixed price, cost reimbursement, or time and materials; (9) The acquisition... a small disadvantaged business set-aside if applicable, and that no other public communication...

  18. Measurement of the Ratio of Branching Fractions B(D0 -> K+ pi-)/B(D0 -> K- pi+) using the CDF II Detector

    CERN Document Server

    Abulencia, A; Adelman, J; Affolder, T; Akimoto, T; Albrow, M G; Ambrose, D; Amerio, S; Amidei, D; Anastassov, A; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arguin, J F; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Azfar, F; Azzi-Bacchetta, P; Azzurri, P; Bacchetta, N; Bachacou, H; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Baroiant, S; Bartsch, V; Bauer, G; Bedeschi, F; Behari, S; Belforte, S; Bellettini, G; Bellinger, J; Belloni, A; Ben Haim, E; Benjamin, D; Beretvas, A; Beringer, J; Berry, T; Bhatti, A; Binkley, M; Bisello, D; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bölla, G; Bolshov, A; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Bromberg, C; Brubaker, E; Budagov, Yu A; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Byrum, K L; Cabrera, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carlsmith, D; Carosi, R; Carron, S; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chapman, J; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chou, J P; Chu, P H; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Ciljak, M; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Coca, M; Compostella, G; Convery, M E; Conway, J; Cooper, B; Copic, K; Cordelli, M; Cortiana, G; Cresciolo, F; Cruz, A; Cuenca-Almenar, C; Cuevas-Maestro, J; Culbertson, R; Cyr, D; Da Ronco, S; D'Auria, S; D'Onofrio, M; Dagenhart, D; De Barbaro, P; De Cecco, S; Deisher, A; De Lentdecker, G; Dell'Orso, Mauro; Delli Paoli, F; Demers, S; Demortier, L; Deng, J; Deninno, M; De Pedis, D; Derwent, P F; Dionisi, C; Dittmann, J R; Di Turo, P; Dorr, C; Donati, S; Donega, M; Dong, P; Donini, J; Dorigo, T; Dube, S; Ebina, K; Efron, J; Ehlers, J; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, I; Fedorko, W T; Feild, R G; Feindt, M; Fernández, J P; Field, R; Flanagan, G; Flores-Castillo, L R; Foland, A; Forrester, S; Foster, G W; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; García, J E; García-Sciveres, M; Garfinkel, A F; Gay, C; Gerberich, H; Gerdes, D; Giagu, S; Giannetti, P; Gibson, A; Gibson, K; Ginsburg, C; Giokaris, N; Giolo, K; Giordani, M; Giromini, P; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Goldstein, J; Gómez, G; Gómez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Gotra, Yu; Goulianos, K; Gresele, A; Griffiths, M; Grinstein, S; Grosso-Pilcher, C; Grundler, U; Guimarães da Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, S R; Hahn, K; Halkiadakis, E; Hamilton, A; Han, B Y; Han, J Y; Handler, R; Happacher, F; Hara, K; Hare, M; Harper, S; Harr, R F; Harris, R M; Hatakeyama, K; Hauser, J; Hays, C; Heijboer, A; Heinemann, B; Heinrich, J; Herndon, M; Hidas, D; Hill, C S; Hirschbuehl, D; Höcker, A; Holloway, A; Hou, S; Houlden, M; Hsu, S C; Huffman, B T; Hughes, R E; Huston, J; Incandela, J R; Introzzi, G; Iori, M; Ishizawa, Y; Ivanov, A; Iyutin, B; James, E; Jang, D; Jayatilaka, B; Jeans, D; Jensen, H; Jeon, E J; Jindariani, S; Jones, M; Joo, K K; Jun, S Y; Junk, T R; Kamon, T; Kang, J; Karchin, P E; Kato, Y; Kemp, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kirsch, L; Klimenko, S; Klute, M; Knuteson, B; Ko, B R; Kobayashi, H; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kovalev, A; Kraan, A C; Kraus, J; Kravchenko, I; Kreps, M; Kroll, J; Krumnack, N; Kruse, M; Krutelyov, V; Kuhlmann, S E; Kusakabe, Y; Kwang, S; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; LeCompte, T; Lee, J; Lee, Y J; Lee, S W; Lefèvre, R; Leonardo, N; Leone, S; Levy, S; Lewis, J D; Lin, C; Lin, C S; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, T; Lockyer, N S; Loginov, A; Loreti, M; Loverre, P F; Lu, R S; Lucchesi, D; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; Mack, P; MacQueen, D; Madrak, R; Maeshima, K; Mäki, T; Maksimovic, P; Malde, S; Manca, G; Margaroli, F; Marginean, R; Marino, C; Martin, A; Martin, V; Martínez, M; Maruyama, T; Matsunaga, H; Mattson, M E; Mazini, R; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Von der Mey, M; Miao, T; Miladinovic, N; Miles, J; Miller, R; Miller, J S; Mills, C; Milnik, M; Miquel, R; Mitra, A; Mitselmakher, G; Miyamoto, A; Moggi, N; Mohr, B; Moore, R; Morello, M; Movilla-Fernández, P A; Mülmenstädt, J; Mukherjee, A; Müller, T; Mumford, R; Murat, P; Nachtman, J; Naganoma, J; Nahn, S; Nakano, I; Napier, A; Naumov, D; Necula, V; Neu, C; Neubauer, M S; Nielsen, J; Nigmanov, T; Nodulman, L; Norniella, O; Nurse, E; Ogawa, T; Oh, S H; Oh, Y D; Okusawa, T; Oldeman, R; Orava, R; Österberg, K; Pagliarone, C; Palencia, E; Paoletti, R; Papadimitriou, V; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, Aldo L; Phillips, T J; Piacentino, G; Piedra, J; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Portell, X; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohos, F; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Rakitine, A; Rappoccio, S; Ratnikov, F; Reisert, B; Rekovic, V; Van Remortel, N; Renton, P B; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robertson, W J; Robson, A; Rodrigo, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Rott, C; Ruiz, A; Russ, J; Rusu, V; Saarikko, H; Sabik, S; Safonov, A; Sakumoto, W K; Salamanna, G; Salto, O; Saltzberg, D; Sánchez, C; Santi, L; Sarkar, S; Sartori, L; Sato, K; Savard, P; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, E E; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, A L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sfiligoi, I; Shapiro, M D; Shears, T G; Shepard, P F; Sherman, D; Shimojima, M; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sinervo, P; Sisakian, A; Sjölin, J; Skiba, A; Slaughter, A J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Söderberg, M; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spezziga, M; Spinella, F; Spreitzer, T; Squillacioti, P; Stanitzki, M; Staveris-Polykalas, A; Saint-Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Stuart, D; Suh, J S; Sukhanov, A; Sumorok, K; Sun, H; Suzuki, T; Taffard, A; Takashima, R; Takeuchi, Y; Takikawa, K; Tanaka, M; Tanaka, R; Tanimoto, N; Tecchio, M; Teng, P K; Terashi, K; Tether, S; Thom, J; Thompson, A S; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Tonnesmann, M; Torre, S; Torretta, D; Tourneur, S; Trischuk, W; Tsuchiya, R; Tsuno, S; Turini, N; Ukegawa, F; Unverhau, T; Uozumi, S; Usynin, D; Vaiciulis, A W; Vallecorsa, S; Varganov, A; Vataga, E; Velev, G; Veramendi, G; Veszpremi, V; Vidal, R; Vila, I; Vilar, R; Vine, T; Vollrath, I; Volobuev, I P; Volpi, G; Würthwein, F; Wagner, P; Wagner, R G; Wagner, R L; Wagner, W; Wallny, R; Walter, T; Wan, Z; Wang, S M; Warburton, A; Waschke, S; Waters, D; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Wright, T; Wu, X; Wynne, S M; Yagil, A; Yamamoto, K; Yamaoka, J; Yamashita, T; Yang, C; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zetti, F; Zhang, X; Zhou, J

    2006-01-01

    We present a measurement of R_B, the ratio of the branching fraction for the rare decay D0 -> K+ pi- to that for the Cabibbo-favored decay D0 -> K- pi+. Charge conjugate decays are implicitly included. A signal of 2005 +/- 104 events for the decay D0 -> K+ pi- is obtained using the CDF II detector at the Fermilab Tevatron collider. The data set corresponds to an integrated luminosity of 0.35 1/fb produced in p-bar/p collisions at sqrt{s}=1.96 TeV. Assuming no mixing, we find R_B = [ 4.05 +/- 0.21 (stat) +/- 0.11 (syst) ] x 10(-3). This measurement is consistent with the world average, and comparable in accuracy with the best measurements from other experiments.

  19. Pocket book of the metal trade. Vol. 1. Metals and trading conditions. 11. rev. ed.; Taschenbuch des Metallhandels. Bd. 1. Metalle und Handelsbedingungen

    Energy Technology Data Exchange (ETDEWEB)

    Schmitz, Ralf (ed.); Dietz, Ferdinand; Kammer, Catrin; Mohr, Heinz; Zocher, Nadine

    2008-07-01

    Vol. 1 of the pocket book on metals and trading conditions comprises the following chapters: 1. Metal, a raw material; 2. Metal stock exchanges; 3. Trading conditions and standards; 4. Addresses, organisations, associations; 5. Metals dictionary D-E-F; 6. List of commodities for external trading; 7. Statistics (prices, production, consumption). [German] Der erste Band ueber Metalle und Handelsbedingungen ist in folgende Kapitel unterteilt: 1. Der Rohstoff Metall; 2. Die Metallboersen; 3. Handelsbedingungen/Normen; 4. Anschriften, Organisationen, Verbaende; 5. Metall Woerterbuch: Deutsch-Englisch Franzoesisch; 6. Warenverzeichnis fuer den Aussenhandel und 7. Statistik (Preis-, Produktions- und Verbrauchsstatistik).

  20. Network psycho-social emergency support. Implementation plans. Vol. 2. Quality standards of education and training; Netzwerk Psychosoziale Notfallversorgung. Umsetzungsrahmenplaene. Bd. 2. Qualitaet in Aus- und Fortbildung

    Energy Technology Data Exchange (ETDEWEB)

    Beerlage, Irmtraud; Springer, Silke; Hering, Thomas; Arndt, Dagmar; Noerenberg, Liane

    2009-07-01

    This report focuses on the steps taken to ensure the implementation of a quality-assured, German-wide harmoniously and structurally integrated and organized emergency psycho-social support (EPSS) on the basis of recommendations -presented on behalf of the German Federal Ministry of the Interior in July 2004 -on the implementation of EPSS as an integral part of civil protection. At the level of the German Laender, a call for action was issued with regard to statutory mandated regulations for the integration of EPSS in relief actions by defined executive positions of psycho-social support measures as well as in short-term and long-term psycho-social aftercare, which has been extensively organized in advance. At federal level, a call for action was issued with regard to the provision of expert and management resources for a concerted crisis management of the Federal Government and the German Laender, also with regard to EPSS. This particularly refers to the convening of an accreditation committee for the evaluation of educational measures in connection with EPSS and with the objective of introducing uniform federal quality standards as well as creating a German-wide available database based on a uniform federal query of EPSS resources for short-term and long-term aftercare for victims, next-of-kin and bereaved as well as for emergency personnel involved in civil protection.The report contains the results of further clarification processes with regard to the implementation of the recommendations, which are principally embraced by the authorities, organizations, churches and associations involved in the development, in co-ordination with the contracting party. Volume II includes a synopsis of currently available possibilities to finance EPSS for emergency personnel as well as victims, next-of-kin and bereaved and the legal foundations, as well as derived recommendations in consideration of municipal and inner-institutional regulations of authorities and organizations involved in civil protection, and forms of cross-financing which have been implemented in various associations (workings groups, foundations); a comparative analysis of 36 curricula in connection with EPSS qualification measures, based on a uniform matrix; the documentation and evaluation of a workshop conference on the development of (minimum) quality standards of EPSS.

  1. B-D试验阳性结果相关因素浅析%Analysis on correlative factors of patients with positive result of B-D test

    Institute of Scientific and Technical Information of China (English)

    陈洁红; 郑立; 陈英群; 郑玩娟; 卢斌; 黄华兰; 王逸茹

    2004-01-01

    @@ 我院自2001年12月开始使用脉动真空灭菌器,根据消毒技术规范要求,坚持每天第1炉空锅进行B-D试验.B-D试验的全称叫布维-狄克试验(Bowie-Dick Test),其原理是使试验包成为灭菌室内残留空气的聚焦点,包内的可透气性布料极易"吸附"或"捕获"残留冷空气,从而迅速准确地监测脉动真空压力蒸汽灭菌器真空系统的有效性.

  2. 13 CFR 124.112 - What criteria must a business meet to remain eligible to participate in the 8(a) BD program?

    Science.gov (United States)

    2010-01-01

    ... to any person or entity affiliated with such individuals; (6) If it is an approved protege, a... mentor/protege relationship. See § 124.520(b)(4) for additional annual requirements; (7) IRS Form...

  3. Giraut de Borneil, “Quan lo fregz e·l glatz e la neus” (BdT 242.60

    Directory of Open Access Journals (Sweden)

    Pietro G. Beltrami

    2011-12-01

    Full Text Available This paper provides a critical edition, with a new hypothesis concerning two difficult loci, of “Quan lo fregz e·l glatz e la neus”, one of the most significant love songs by Giraut de Borneil. For l. 48 (according to the order of the stanzas in Kolsen’s edition which is confirmed here, I will argue that “gers”, present in nearly all the manuscripts and editions, but never explained satisfactorily and unique from the lexical viewpoint, is a ghost word. Thus I will suggest accepting the lesson of ms. B as a suitable, ancient conjecture: ‘of those who are inside (the beseiged castle and forced to surrender’ que an grans guerriers, ‘who have great enemies’. For l. 58 none of the solutions put forward so far are convincing, thus I will tentatively propose a new conjecture: the lover fears that his life will become plus breus... “que del quint dels quars”, ‘shorter that the fifth of the quarter (of the day’, that is, it will be cut off. This restores a rhetorical figure of repetition that marks the end of each stanza after the second and which has been lost in nearly all the manuscripts and editions. My reading of the text will underline its distinctive aspects: a large number of quite difficult similes, emphasis on the figure of the lover, a lack of the author intervention and of the sententiae and forms of argument that characterise this poet, a fast pace created by the syntactic and rhetorical structure. I will also examine all that may serve to place the text within a particular historical context, although despite the many hypotheses, the only sure element is that it was written for a courtly occasion in the presence of Richard the Lionheart.

  4. Biography as an art form: the story of Helen Flanders Dunbar, M.D., Ph.D., B.D., and Med. Sci. D.

    Science.gov (United States)

    Hart, Curtis W

    2014-06-01

    Helen Flanders Dunbar (1902-1959) was a physician, medieval and Renaissance scholar, theologian, and founder of the American Psychosomatic Society and its journal Psychosomatic Medicine. Her contributions are not currently well known but deserve recognition from all those involved or interested in the dialogue between medicine and spirituality. This essay explores Dunbar's personal history and professional achievements. It focuses particular attention on a feminist perspective regarding her life and work. It will conclude with a discussion of how biography, as an art form, transforms both author and audience. This essay was originally presented as the Second Annual J.R. Williams Memorial Lecture on Spirituality and Medicine at the Tulane School of Medicine in fall 2013.

  5. Solving the Big Data (BD) Problem in Advanced Manufacturing (Subcategory for work done at Georgia Tech. Study Process and Design Factors for Additive Manufacturing Improvement)

    Energy Technology Data Exchange (ETDEWEB)

    Clark, Brett W. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Diaz, Kimberly A. [Georgia Inst. of Technology, Atlanta, GA (United States); Ochiobi, Chinaza Darlene [Georgia Inst. of Technology, Atlanta, GA (United States); Paynabar, Kamran [Georgia Inst. of Technology, Atlanta, GA (United States)

    2015-09-01

    3D printing originally known as additive manufacturing is a process of making 3 dimensional solid objects from a CAD file. This ground breaking technology is widely used for industrial and biomedical purposes such as building objects, tools, body parts and cosmetics. An important benefit of 3D printing is the cost reduction and manufacturing flexibility; complex parts are built at the fraction of the price. However, layer by layer printing of complex shapes adds error due to the surface roughness. Any such error results in poor quality products with inaccurate dimensions. The main purpose of this research is to measure the amount of printing errors for parts with different geometric shapes and to analyze them for finding optimal printing settings to minimize the error. We use a Design of Experiments framework, and focus on studying parts with cone and ellipsoid shapes. We found that the orientation and the shape of geometric shapes have significant effect on the printing error. From our analysis, we also determined the optimal orientation that gives the least printing error.

  6. Tracking Advanced Planetary Systems (TAPAS) with HARPS-N. III. HD 5583 and BD+15 2375 - two cool giants with warm companions

    CERN Document Server

    Niedzielski, A; Nowak, G; Adamów, M; Kowalik, K; Wolszczan, A; Deka-Szymankiewicz, B; Adamczyk, M; Maciejewski, G

    2016-01-01

    Evolved stars are crucial pieces to understand the dependency of the planet formation mechanism on the stellar mass and to explore deeper the mechanism involved in star-planet interactions. Over the past ten years, we have monitored about 1000 evolved stars for radial velocity variations in search for low-mass companions under the Penn State - Torun Centre for Astronomy Planet Search program with the Hobby-Eberly Telescope. Selected prospective candidates that required higher RV precision measurements have been followed with HARPS-N at the 3.6 m Telescopio Nazionale Galileo under the TAPAS project. We aim to detect planetary systems around evolved stars to be able to build sound statistics on the frequency and intrinsic nature of these systems, and to deliver in-depth studies of selected planetary systems with evidence of star-planet interaction processes. For HD 5583 we obtained 14 epochs of precise RV measurements collected over 2313 days with the Hobby-Eberly Telescope (HET), and 22 epochs of ultra-precise...

  7. Testing the Standard Model and searching for New Physics with $B_d \\to \\pi \\pi$ and $B_s \\to K K$ decays

    CERN Document Server

    Ciuchini, M; Mishima, S; Silvestrini, L

    2012-01-01

    We propose to perform a combined analysis of $B \\to \\pi\\pi$ and $B_s \\to K^+ K^-$ modes, in the framework of a global CKM fit. The method optimizes the constraining power of these decays and allows to derive constraints on NP contributions to penguin amplitudes or on the $B_s$ mixing phase. We illustrate these capabilities with a simplified analysis using the recent measurements by the LHCb Collaboration, neglecting correlations with other SM observables.

  8. Joint-research project. The world of renewable energies: powerado. Final report. Part 2; Verbundforschungsprojekt. Erlebniswelt erneuerbare Energien: powerado. Endbericht. Bd. 2

    Energy Technology Data Exchange (ETDEWEB)

    Scharp, Michael (ed.)

    2009-02-15

    The objective of the research project 'The world of renewable energies: Powerado' was to improve communication aimed at conveying renewable energies to children. In order to achieve his aim, materials for different age groups and multipliers have been developed. These helped determining successful strategies for communicating renewable energies. There were several reasons for the need of such a project. It may be the case that renewable energies have been included into the syllabus of primary schools, but they still have no prominent role at schools. Additionally, the training of multipliers for renewable energies shows severe deficits. The project consisted of ten interconnected modules which explicitly are described. Overall, the powerado project was a huge success. 58,000 estimated multipliers, children, adolescents and persons generally being interested in renewable energies have been reached by the project and its modules. So the powerado project achieved its main objective improving communication of renewable energies.

  9. BD S三频观测值线性组合分析%Analysing The Linear Combination of the BDS Triple Frequency Observation

    Institute of Scientific and Technical Information of China (English)

    凌云; 侍荣; 丁锁妹

    2015-01-01

    Briefly introduces the theoretical basis of the linear combination of the observation in GNSS data processing .Based on the BDS triple frequency observation ,it makes a deep analysis in the characteristics of the different linear combinations of the BDS observations .And it provide the reference for BDS data processing .%简单介绍了GNSS数据处理中观测值线性组合的理论基础。基于BDS三频观测值,深入分析不同BDS观测值线性组合所具备的特点,为BDS数据处理提供参考。

  10. Assessment of the BD MGIT TBc Identification Test for the Detection of Mycobacterium tuberculosis Complex in a Network of Mycobacteriology Laboratories

    Directory of Open Access Journals (Sweden)

    Diana Machado

    2014-01-01

    Full Text Available We evaluate the performance of the TBcID assay in a panel of 100 acid-fast bacilli cultures. Sixty-four isolates were TBcID positive for Mycobacterium tuberculosis complex (MTBC, whereas 36 gave negative results. These included 28 nontuberculous mycobacteria, one nonmycobacterial isolate, one M. tuberculosis, and six M. bovis BCG strains. This corresponds to a sensitivity of 90.14%, specificity of 100%, and positive and negative predictive values of 100% and 80.55%, respectively. The test is rapid, easy to perform and interpret, and does not require sample preparation or instrumentation. However, a negative result does not exclude the presence of a strain belonging to MTBC, especially when mutations in mpb64 gene are present or some M. bovis BCG strains are isolated. The TBcID showed potential to assist in the identification of MTBC when the implementation and usage of molecular methods are often not possible, principally in resource-limited countries.

  11. Radiation, fields and waves. Non-ionizing radiation in everyday life. Vol. 15. Seminar lectures; Strahlen, Felder und Wellen. Nichtionisierende Strahlung im taeglichen Umfeld. Bd. 15. Seminarband

    Energy Technology Data Exchange (ETDEWEB)

    Behling, G.; Koller, U.; Rauh, K.; Haury, H.J. [comps.

    1999-11-01

    Experts from science and administration informed the participants about recent results of scientific research and the applicable laws and regulations. Potential health hazards and recommended protective measures have been discussed. The publication presents the lectures held at the seminar. (orig./CB) [German] Fachleute aus Wissenschaft und von Behoerden informierten ueber aktuelle Erkenntnisse sowie das gesetzliche Regelwerk. Aus unterschiedlichen Blickwinkeln wurden moegliche gesundheitliche Risiken und vorgeschlagene Sicherheitsempfehlungen diskutiert. Der vorliegende Band enthaelt die ausgearbeiteten Vortraege. (orig./MG)

  12. Sail d’Escola, “Gran esfortz fai qui chanta ni·s deporta” (BdT 430.1

    Directory of Open Access Journals (Sweden)

    Oriana Scarpati

    2009-12-01

    Full Text Available The only extant poem by Sail d’Escola, “Gran esfortz fai qui chanta ni·s deporta”, must have been quite successful with the troubadours since its melody was reused several times. Without a doubt its interest also lies in the fact that it mentions another (or others? poem in which the troubadour has recourse to the ‘mala canso’, believing, quite rightly, that he may offend the lady who proved to be a bad ‘amigua’. The text is ambiguous: it appears to be a love song asking for forgiveness to a lady who had previously been treated badly, but it also contains hidden threats of abuse, should the lady not show herself to be once more well-disposed towards her lover. This paper will propose a new interpretation of the simile in ll. 5-7, as well as some corrections to the previous edition (Chabaneau.

  13. Search for $B_s \\to \\mu^+\\mu^-$ and $B_d \\to \\mu^+\\mu^-$ Decays with CDF II

    Energy Technology Data Exchange (ETDEWEB)

    Aaltonen, T.; /Helsinki Inst. of Phys.; Alvarez Gonzalez, B.; /Oviedo U. /Cantabria Inst. of Phys.; Amerio, S.; /INFN, Padua; Amidei, D.; /Michigan U.; Anastassov, A.; /Northwestern U.; Annovi, A.; /Frascati; Antos, J.; /Comenius U.; Apollinari, G.; /Fermilab; Appel, J.A.; /Fermilab; Apresyan, A.; /Purdue U.; Arisawa, T.; /Waseda U. /Dubna, JINR

    2011-07-01

    A search has been performed for B{sub s}{sup 0} {yields} {mu}{sup +}{mu}{sup -} and B{sup 0} {yields} {mu}{sup +}{mu}{sup -} decays using 7 fb{sup -1} of integrated luminosity collected by the CDF II detector at the Fermilab Tevatron collider. The observed number of B{sup 0} candidates is consistent with background-only expectations and yields an upper limit on the branching fraction of {Beta}(B{sup 0} {yields} {mu}{sup +}{mu}{sup -}) < 6.0 x 10{sup -9} at 95% confidence level. We observe an excess of B{sub s}{sup 0} candidates. The probability that the background processes alone could produce such an excess or larger is 0.27%. The probability that the combination of background and the expected standard model rate of B{sub s}{sup 0} {yields} {mu}{sup +}{mu}{sup -} could produce such an excess or larger is 1.9%. These data are used to determine {Beta}(B{sub s}{sup 0} {yields} {mu}{sup +}{mu}{sup -}) = (1.8{sub -0.9}{sup +1.1}) x 10{sup -8} and provide an upper limit of {Beta}(B{sub s}{sup 0} {yields} {mu}{sup +}{mu}{sup -}) < 4.0 x 10{sup -8} at 95% confidence level.

  14. Raimon de las Salas (? ~ Bertran Folco d’Avigno (?, “Bertran, si fossetz tant gignos” (BdT 406.16 = 83.1

    Directory of Open Access Journals (Sweden)

    Giuseppe Noto

    2009-12-01

    Full Text Available This paper will offer a new edition, with critical apparatus, commentary and translation, of the ‘tenso’ “Bertran, si fossetz tant gignos”, transmitted by chansonniers ADIK and perhaps ascribable to Raimon de las Salas and Bertran Folco d’Avigno. It is a debate (that takes place within the framework of the Albigensian Crusade and was most likely composed in northern Italy aimed at establishing whether, as far as military prowess, hospitality and courtly values as a whole are concerned, the Lombards (where Lombardy obviously means northern Italy as a whole are better than the Provençals (that is the exponents of the feudal culture of all the courts of southern France put together. Of particular interest is the contrast between Occitania and its typically courtly ethics and the exclusively economic (indeed economicistic outlook of the Lombards.

  15. Evaluation of direct inoculation of the BD PHOENIX system from positive BACTEC blood cultures for both Gram-positive cocci and Gram-negative rods

    NARCIS (Netherlands)

    J. Beuving (Judith); C.F. van der Donk (Christina); C.F. Linssen (Catharina F.); P. Wolffs (Petra); A. Verbon (Annelies)

    2011-01-01

    textabstractBackground: Rapid identification (ID) and antibiotic susceptibility testing (AST) of the causative micro-organism of bloodstream infections result in earlier targeting of antibiotic therapy. In order to obtain results of ID and AST up to 24 hours earlier, we evaluated the accuracy of dir

  16. An Ultraviolet to Mid-Infrared Study of the Physical and Wind Properties of HD 164270 (WC9) and Comparison to BD+30 3639 ([WC9])

    CERN Document Server

    Crowther, P; Smith, J D; Crowther, Paul; Morris, Pat; Smith, JD

    2006-01-01

    We present new Spitzer IRS observations of HD164270 (WC9, WR103). A quantitative analysis of the UV, optical, near- and mid-IR spectrum of HD164270 is presented, allowing for line blanketing and wind clumping, revealing T* ~ 48kK, log L/L_sun ~ 4.9, dM/dt ~ 1e-5 M_sun/yr for a volume filling factor of f \\~ 0.1. Our models predict that He is partially recombined in the outer stellar wind, such that recent radio-derived mass-loss rates of WC9 stars have been underestimated. We obtain C/He ~ 0.2 and O/He ~ 0.01 by number from optical diagnostics. Mid-IR fine structure lines of [NeII] 12.8 and [SIII] 18.7micron are observed, with [NeIII] and [SIV] absent. From these we obtain Ne/He ~ Ne^+/He = 2.2e-3 by number, 7 times higher than the Solar value (as recently derived by Asplund et al.), and S/He ~ S^2+/He = 5.1e-5 by number. From a comparison with similar results for other WC subtypes we conclude that WC9 stars are as chemically advanced as earlier subtypes. We consider why late WC stars are exclusively observed ...

  17. Renewable energies in the primary school. Vol. 1. Energy (conservation). Solar energy. 2. rev. ed.; Erneuerbare Energien in der Grundschule. Bd. 1. Energie(sparen). Sonnenenergie

    Energy Technology Data Exchange (ETDEWEB)

    Kaiser, Astrid; Lueschen, Iris; Reimer, Monika [Oldenburg Univ. (Germany)

    2012-11-01

    The rearrangement of the energy supply to renewable energies is an issue of central importance for the future of our society. This rearrangement has to be supported by broad segments of the population in order to achieve the intended impact. Under this aspect, the authors of the contribution under consideration report on the item of renewable energy sources in primary schools. This contribution consists of the following chapters: (1) Why ''Renewable Energies'' in knowledge lessons? (Didactical orientation); (2) Aspects of science especially for girls (Didactical potentials); (3) Hints for the handling of the practice material; (4) Factual information and practice materials for the modules ''Energy conservation'' and ''Solar energy''.

  18. Shaft barriers for underground waste repositories in abandoned salt mines. Preparatory project. Vol. 2. Annex; Schachtverschluesse fuer untertaegige Deponien in Salzbergwerken. Vorprojekt. Bd. 2. Anhang

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, M.W. [GSF - Forschungszentrum fuer Umwelt und Gesundheit, Remlingen (Germany). Forschungsbergwerk Asse; Fruth, R. [GSF - Forschungszentrum fuer Umwelt und Gesundheit, Remlingen (Germany). Forschungsbergwerk Asse; Stockmann, N. [GSF - Forschungszentrum fuer Umwelt und Gesundheit, Remlingen (Germany). Forschungsbergwerk Asse; Birthler, H. [Gesellschaft fuer Anlagen- und Reaktorsicherheit mbH Greece, Braunschweig (Germany). Fachbereich Endlagersicherheitsforschung; Boese, B. [Gesellschaft fuer Anlagen- und Reaktorsicherheit mbH Greece, Braunschweig (Germany). Fachbereich Endlagersicherheitsforschung; Storck, R. [Gesellschaft fuer Anlagen- und Reaktorsicherheit mbH Greece, Braunschweig (Germany). Fachbereich Endlagersicherheitsforschung; Sitz, P. [Technische Univ. Bergakademie Freiberg (Germany). Inst. fuer Bergbau; Krausse, A. [Technische Univ. Bergakademie Freiberg (Germany). Inst. fuer Bergbau; Eulenberger, K.H. [Technische Univ. Bergakademie Freiberg (Germany). Inst. fuer Bergbau; Schleinig, J.P. [Technische Univ. Bergakademie Freiberg (Germany). Inst. fuer Bergbau; Duddeck, H. [Technische Univ. Braunschweig (Germany). Inst. fuer Statik; Ahrens, H. [Technische Univ. Braunschweig (Germany). Inst. fuer Statik; Menzel, W. [IfG Inst. fuer Gebirgsmechanik GmbH, Leipzig (Germany); Salzer, K. [IfG Inst. fuer Gebirgsmechanik GmbH, Leipzig (Germany); Minkley, W. [IfG Inst. fuer Gebirgsmechanik GmbH, Leipzig (Germany); Busche, H. [Kali und Salz AG, Kassel (Germany); Lindloff, U. [Kali und Salz AG, Kassel (Germany); Gierenz, S. [Kali und Salz AG, Kassel (Germany)

    1995-12-31

    This preparatory study, ``Shaft barriers for underground waste repositories in abandoned salt mines``, was to demonstrate the current scientific and technological know-how based on a comprehensive analysis of the barrier design concepts or established structures intended to serve as barriers in abandoned shafts of potash or rock salt mines. Taking as a basis the current regulatory regime and the available know-how on barrier systems in underground waste repositories taken into account so far in plan approval and licensing procedures, as well as the state of the art, concepts are developed as technical guides and models of barrier systems for mine shafts. The required research work for the various components of a shaft barrier is shown, particularly relating to aspects such as materials suitability and technical realisation. Immediate demand for research activities is shown with regard to the available potentials of mathematic and numeric geotechnical and hydrogeologic calculation models required in order to give proof of the long-term workability of shaft barriers. The authors are of the opinion that the following activities are required in order to meet the research demand quantified: (1) Laboratory and bench-scale experiments for determination of the efficiency of various sealing materials and backfilling materials, and (2) an in-situ, large-scale experiment in order to demonstrate the suitability of low-consolidation shotter columns, or constructional technologies. The laboratory work can be done in the facilities of the GSF research mine of Asse, the Freiburg Mining Academy, and the Institut fuer Gebirgsmechanik in Leipzig, and the benchmark experiments also at the Asse site in the research mine. The Kali und Salz Beteiligungs AG is prepared to offer its mine Salzdetfurth II as a site for the large-scale experiment. (orig.) [Deutsch] Im Rahmen der Vorstudie ``Schachtverschluesse fuer Untertagedeponien in Salzbergwerken`` wird ausgehend von einer umfangreichen Analyse der bisher realisierten bzw. konzipierten Verschlussmassnahmen von Schaechten des Kali- und Steinsalzbergbaues der gegenwaertige Stand von Wissenschaft und Technik abgeleitet. Auf der Grundlage der vorhandenen gesetzlichen Regelwerke und des mit zu beruecksichtigenden Kenntnisstandes zu Verschlusssystemen fuer UTD in bisher durchgefuehrten Planfeststellungs- und Genehmigungsverfahren sowie des Standes von Wissenschaft und Technik wurden Konzepte fuer die technischen Loesungen von Verschlusssystemen fuer Schaechte entwickelt. Der sich daraus ableitende Forschungsbedarf zu den einzelnen Elementen eines Schachtverschlusses, insbesondere unter dem Aspekt der Materialauswahl und der technischen Realisierbarkeit, wird ausgewiesen. Im Hinblick auf den Nachweis der langzeitlichen Funktionsfaehigkeit von Schachtverschluessen werden die vorhandenen Moeglichkeiten mathematisch-numerischer geotechnischer und hydrogeologischer Berechnungsmodelle dargestellt. Dabei besteht ein unmittelbarer Forschungsbedarf. Die Verfasser sind der Auffassung, dass zur Abarbeitung des ermittelten Forschungsbedarfes 1. Labor - und Technikumsversuche zur Wirksamkeit verschiedener Dichtmaterialien und Widerlagerbaustoffe sowie 2. ein In-situ-Grossversuch zur Klaerung der Einsatzmoeglichkeiten setzungsarmer Schottersaeulen und Einbautechnologien der Verschlussbauwerke erforderlich sind. Fuer die Laboruntersuchungen stehen die labortechnischen Einrichtungen des GSF-Forschungsbergwerkes Asse, der Bergakademie Freiberg und des Institutes fuer Gebirgsmechanik, Leipzig, sowie fuer die Technikumsversuche das Forschungsbergwerk Asse zur Verfuegung. Als Versuchsort fuer den In-situ-Grossversuch bietet die Kali und Salz Beteiligungs AG den Schacht Salzdetfurth II an. (orig.)

  19. Measurement of the Branching Fractions and CP Asymmetries of B-->D0(cp)K- Decays with the BaBar detector

    CERN Document Server

    Aubert, B; Abrams, G S; Adye, T; Ahmed, S; Alam, M S; Albert, J; Aleksan, Roy; Allison, J; Allmendinger, T; Altenburg, D; Andreotti, M; Angelini, C; Anulli, F; Aston, D; Azzolini, V; Baak, M; Back, J J; Bailey, S; Baldini-Ferroli, R; Band, H R; Banerjee, Sw; Barate, R; Bard, D J; Barlow, N R; Barlow, R J; Barrett, M; Bartoldus, R; Batignani, G; Bauer, J M; Beck, T W; Behera, P K; Bellini, F; Benayoun, M; Berger, N; Bernard, D; Berryhill, J W; Best, D; Bettarini, S; Bettoni, D; Bevan, A J; Bhimji, W; Bianchi, F; Biasini, M; Blanc, F; Blaylock, G; Blinov, A E; Blinov, V E; Bloom, P; Bóna, M; Bondioli, M; Bonneaud, G R; Borgland, A W; Bosisio, L; Boutigny, D; Bowerman, D A; Boyarski, A M; Boyd, J T; Bozzi, C; Brandenburg, G; Brandt, T; Brau, J E; Breon, A B; Briand, H; Brochard, F; Brose, J; Brown, C L; Brown, C M; Brown, D; Brown, D N; Bruinsma, M; Brunet, S; Bucci, F; Buchanan, C; Buchmüller, O L; Bugg, W; Bulten, H; Burchat, Patricia R; Button-Shafer, J; Buzzo, A; Côté, D; Cahn, R N; Calabrese, R; Calcaterra, A; Calderini, G; Campagnari, C; Capra, R; Carpinelli, M; Cartaro, C; Cavallo, N; Cavoto, G; Chaisanguanthum, K S; Chao, M; Charles, E; Charles, M J; Chauveau, J; Chavez, C A; Chen, A; Chen, E; Chen, J C; Chen, S; Cheng, B; Cheng, C H; Chevalier, N; Christ, S; Cibinetto, G; Clark, P J; Claus, R; Cochran, J; Colecchia, F; Coleman, J P; Contri, R; Convery, M R; Cormack, C M; Cossutti, F; Cottingham, W N; Couderc, F; Covarelli, R; Cowan, G; Cowan, R; Crawley, H B; Cremaldi, L M; Cristinziani, M; Crosetti, G; Çuhadar-Dönszelmann, T; Dahmes, B; Dallapiccola, C; Danielson, N; Dasu, S; Datta, M; Dauncey, P D; David, P; Davier, M; Davis, C L; Day, C T; De Groot, N; De Nardo, Gallieno; Del Buono, L; Della Ricca, G; Di Lodovico, F; Dickopp, M; Dittongo, S; Dong, D; Dorfan, J; Dorigo, A; Druzhinin, V P; Dubitzky, R S; Dubois-Felsmann, G P; Dujmic, D; Dunwoodie, W M; Dvoretskii, A; Eckmann, R; Edwards, A J; Egede, U; Eichenbaum, A M; Eigen, G; Eisner, A M; Elmer, P; Elsen, E E; Emery, S; Ernst, J A; Eschenburg, V; Eschrich, I; Fabozzi, F; Faccini, R; Fan, S; Farbin, A; Feltresi, E; Ferrarotto, F; Ferroni, F; Field, R C; Finocchiaro, G; Flack, R L; Flächer, H U; Flood, K T; Ford, K E; Ford, W T; Forster, I J; Forti, F; Fortin, D; Foulkes, S D; Franek, B J; Frey, R; Fritsch, M; Fry, J R; Gabathuler, Erwin; Gaidot, A; Gaillard, J M; Gaillard, J R; Galeazzi, F; Gallo, F; Gamba, D; Gamet, R; Gan, K K; Ganzhur, S F; Gary, J W; Gaspero, M; Gatto, C; Geddes, N I; Gill, M S; Giorgi, M A; Giraud, P F; Giroux, X; Gladney, L; Glanzman, T; Godang, R; Goetzen, K; Golubev, V B; Gopal, G P; Gowdy, S J; Graham, M; Grancagnolo, S; Green, M G; Greene, M G; Grenier, G J; Grenier, P; Gritsan, A V; Grosdidier, G; Groysman, Y; Guo, Q H; Hadavand, H K; Hadig, T; Haire, M; Halyo, V; Hamel de Monchenault, G; Hamon, O; Harrison, P F; Harrison, T J; Hart, A J; Hart, P A; Hartfiel, B L; Harton, J L; Hast, C; Hauke, A; Hawkes, C M; Hearty, C; Held, T; Hertzbach, S S; Heusch, C A; Hicheur, A; Hill, E J; Hitlin, D G; Höcker, A; Hodgkinson, M C; Hollar, J J; Honscheid, K; Hrynóva, T; Hufnagel, D; Hulsbergen, W D; Hutchcroft, D E; Igonkina, O; Innes, W R; Ivanchenko, V N; Izen, J M; Jackson, P D; Jackson, P S; Jacobsen, R G; Jawahery, A; Jayatilleke, S M; Jessop, C P; John, M J J; Johnson, J R; Judd, D; Kadel, R W; Kadyk, J; Kagan, H; Karyotakis, Yu; Kass, R; Kelly, M P; Kelsey, M H; Kerth, L T; Khan, A; Kim, H; Kim, P; Kirkby, D; Kitayama, I; Knecht, N S; Koch, H; Kocian, M L; Kofler, R; Kolomensky, Yu G; Koptchev, V B; Kovalskyi, D; Kowalewski, R V; Kozanecki, Witold; Kravchenko, E A; Krishnamurthy, M; Kroeger, R; Kroseberg, J; Kukartsev, G; Kutter, P E; Kyberd, P; Lacker, H M; Lae, C K; Lafferty, G D; Lamsa, J; Lanceri, L; Lange, D J; Langenegger, U; Lankford, A J; Laplace, S; Latham, T E; Lau, Y P; Lavin, D; Lazzaro, A; Le Diberder, F R; Lees, J P; Legendre, M; Leith, D W G S; Lepeltier, V; Leruste, P; Lewandowski, B; Li Gioi, L; Li, H; Libby, J; Lillard, V; Lista, L; Liu, R; LoSecco, J M; Lo Vetere, M; Lockman, W S; Lombardo, V; London, G W; Long, O; Lou, X C; Lu, A; Lü, C; Luitz, S; Luppi, E; Lusiani, A; Lüth, V; Lutz, A M; Lynch, G; Lynch, H L; Lyon, A J; MacFarlane, D B; Macri, M; Malcles, J; Mallik, U; Mancinelli, G; Mandelkern, M A; Manfredi, P F; Mangeol, D J J; Marchiori, G; Margoni, M; Marsiske, H; Martínez-Vidal, F; Mattison, T S; Mayer, B; Mazur, M A; Mazzoni, M A; McKenna, J A; McMahon, T R; Meadows, B T; Messner, R; Meyer, T I; Meyer, W T; Miftakov, V; Mihályi, A; Mir, L M; Mohanty, G B; Mohapatra, A K; Mommsen, R K; Monge, M R; Monorchio, D; Moore, T B; Morandin, M; Morgan, S E; Morganti, M; Morganti, S; Morii, M; Morton, G W; Muheim, F; Müller, D R; Müller-Pfefferkorn, R; Narsky, I; Nash, J A; Nauenberg, U; Neal, H; Negrini, M; Neri, N; Nesom, G; Nicholson, H; Nikolich, M B; Nogowski, R; O'Grady, C P; Ocariz, J; Oddone, P J; Ofte, I; Olaiya, E O; Olivas, A; Olsen, J; Onuchin, A P; Orimoto, T J; Otto, S; Ozcan, V E; Paar, H P; Paick, K; Palano, A; Palombo, F; Pan, Y; Panetta, J; Panvini, R S; Paoloni, E; Paolucci, P; Parry, R J; Passaggio, S; Patel, P M; Patrignani, C; Patteri, P; Payne, D J; Pelizaeus, M; Perazzo, A; Perl, M; Peruzzi, I M; Petersen, B A; Petersen, T C; Petrak, S; Petzold, A; Piatenko, T; Piccolo, D; Piccolo, M; Piemontese, L; Pierini, M; Pioppi, M; Piredda, G; Pivk, M; Plaszczynski, S; Playfer, S; Pompili, A; Poropat, P; Porter, F C; Posocco, M; Potter, C T; Prell, S; Prepost, R; Pripstein, M; Pulliam, T; Purohit, M V; Qi, N D; Rahatlou, S; Rahimi, A M; Rama, M; Rankin, P; Ratcliff, B N; Raven, G; Re, V; Reidy, J; Ricciardi, S; Richman, J D; Ritchie, J L; Rizzo, G; Roat, C; Roberts, D A; Robertson, S H; Robutti, E; Roe, N A; Röthel, W; Ronan, Michael T; Roney, J M; Rong, G; Roodman, A; Roos, L; Rosenberg, E I; Rotondo, M; Rubin, A E; Ryd, A; Saeed, M A; Safai-Tehrani, F; Saleem, M; Salnikov, A A; Salvatore, F; Samuel, A; Sanders, D A; Sandrelli, F; Santroni, A; Saremi, S; Sarti, A; Satpathy, A; Schalk, T; Schindler, R H; Schott, G; Schrenk, S; Schubert, J; Schubert, Klaus R; Schumm, B A; Schune, M H; Schwiening, J; Schwierz, R; Schwitters, R F; Sciacca, C; Sciolla, G; Seiden, A; Sekula, S J; Serednyakov, S I; Sharma, V; Shelkov, V G; Shen, B C; Simani, M C; Simi, G; Simonetto, F; Sinev, N B; Skovpen, Yu I; Sloane, R J; Smith, A J S; Smith, J G; Snoek, H L; Snyder, A; Sobie, R J; Soffer, A; Soha, A; Sokoloff, M D; Solodov, E P; Spaan, B; Spanier, S M; Spradlin, P; Stängle, H; Steinke, M; Stelzer, J; Stoker, D P; Stroili, R; Strom, D; Stugu, B; Su, D; Sullivan, M K; Summers, D J; Sundermann, J E; T'Jampens, S; Tan, P; Tantot, L; Taras, P; Taylor, F; Taylor, G P; Telnov, A V; Teodorescu, L; Ter-Antonian, R; Therin, G; Thiebaux, C; Thiessen, D; Tiozzo, G; Tisserand, V; Toki, W H; Torrence, E; Tosi, S; Touramanis, C; Treadwell, E; Vasileiadis, G; Vasseur, G; Vavra, J; Verderi, M; Verkerke, W; Vitale, L; Voci, C; Voena, C; Vuagnin, G; Wagner, G; Wagner, S R; Wagoner, D E; Waldi, R; Walsh, J; Wang, K; Wang, P; Wappler, F R; Watson, A T; Weaver, M; Weidemann, A W; Weinstein, A J R; Wenzel, W A; Wilden, L; Williams, D C; Williams, J C; Willocq, S; Wilson, F F; Wilson, J R; Wilson, M G; Wilson, R J; Winter, M A; Wisniewski, W J; Wittgen, M; Won, E; Wong, Q K; Wormser, G; Wright, D H; Wright, D M; Wu, J; Wu, S L; Xie, Y; Yamamoto, R K; Yang, S; Yarritu, A K; Ye, S; Yéche, C; Yi, J; Young, C C; Yu, Z; Yumiceva, F X; Yushkov, A N; Zallo, A; Zeng, Q; Zghiche, A; Zhang, J; Zhang, L; Zhao, H W; Zhu, Y S; Zito, M; De Sangro, R; Del Re, D; La Vaissière, C de

    2004-01-01

    We present a study of B--> D0(CP)K- decays, where D0(CP) is reconstructed in non-CP (K-pi+), CP-even (K-K+,pi-pi+) and CP-odd (KS0 pi0) eigenstates, based on a sample of about 214 million Y(4S) -> BBbar decays collected with the BABAR detector at the PEP-II e+e- storage ring. We measure the ratios of branching fractions R+ = [Br(B- ->D0_CP+ K-)+Br(B+ ->D0_CP+ K+)]/[Br(B- ->D0 K-)] = 0.87 +/- 0.14(stat) +/- 0.06(syst), R- = [Br(B- ->D0_CP- K-)+Br(B+ ->D0_CP- K+)]/[Br(B- ->D0 K-)] = 0.80 +/- 0.14(stat) +/- 0.08(syst), and the CP asymmetries A_CP+ = 0.40 +/- 0.15 (stat) +/- 0.08 (syst) and A_CP- = 0.21 +/- 0.17 (stat) +/- 0.07 (syst) All results are preliminary.

  20. Endocrine-disrupting environmental chemicals - hazards to man and animal; Hormonell wirksame Umweltchemikalien - Gefahr fuer Mensch und Tier? Seminarband der Zentralen Informationsstelle Umweltberatung Bayern. Bd. 12

    Energy Technology Data Exchange (ETDEWEB)

    Behling, G.; Koller, U.; Klemmer, A.; Haury, H.J. [comps.

    1998-08-01

    The spectrum of problems relating to endocrine-disrupting environmental chemicals was presented by competent experts from public authorities and scientific institutions. The lecturers described the current stage and future tasks of research. Their lectures focused on effects of hormone-like substances on humans and animals and an assessment of risk factors on the basis of data from scientific tests and current environmental exposure. There was also a contribution presenting the chemical industry`s view of the matter. [Deutsch] Kompetente Sachverstaendige aus Behoerden und wissenschaftlichen Einrichtungen stellten das Themenspektrum vor, fuehrten in den Forschungsstand ein und zeigten den Forschungsbedarf auf. Der Schwerpunkt lag in der Darstellung der der Auswirkungen hormonell wirksamer Substanzen, wie z.B. DDT, Dioxinen und PCBs, auf Mensch und Tier sowie in der Abschaetzung der Risikofaktoren anhand der bekannten Daten aus wissenschaftlichen Tests sowie der aktuellen Exposition in der Umwelt. Mit einem Beitrag der chemischen Industrie wurde auch deren Einschaetzung der Umweltproblematik aufgezeigt. (orig./MG) m9

  1. Peter Heintel y Ludwig Nagl (editores). Zur Kantforschung der Gegenwart : Darmstadt: Wissenschaftliche Buchgesellschaft, 1981 (Wege der Forschung: Bd. 281)

    OpenAIRE

    Bertomeu, María Julia

    1985-01-01

    Peter Heintel y Ludwig Nagl son los editores de esta obra que reúne un grupo de trabajos ya publicados anteriormente en revistas especializadas entre los años 1954 1974. En el 'Prefacio' Heintel advierte que el propósito de la obra no ha sido elaborar una reconstrucción histórico-filológica de los intérpretes de Kant, sino testificar la actualidad del pensamiento kantiano en el amplio espectro de la filosofía actual y constatar la vigencia de la reflexión trascendental. Ludwig Nagl, co-editor...

  2. 13 CFR 124.111 - Do Community Development Corporations (CDCs) have any special rules for applying to the 8(a) BD...

    Science.gov (United States)

    2010-01-01

    ... federal programs requiring SBA to determine social and economic disadvantage as a condition of eligibility... conducted by one or more individuals determined to have managerial experience of an extent and complexity...) The technical and managerial experience and competence of the individual(s) who will manage...

  3. Evaluation of direct inoculation of the BD PHOENIX system from positive BACTEC blood cultures for both Gram-positive cocci and Gram-negative rods

    Directory of Open Access Journals (Sweden)

    Wolffs Petra FG

    2011-06-01

    Full Text Available Abstract Background Rapid identification (ID and antibiotic susceptibility testing (AST of the causative micro-organism of bloodstream infections result in earlier targeting of antibiotic therapy. In order to obtain results of ID and AST up to 24 hours earlier, we evaluated the accuracy of direct inoculation of the Phoenix system from positive blood cultures (BACTEC by using Serum Separator Tubes to harvest bacteria from positive blood cultures. Results were compared to those of standard Phoenix procedure. Discrepancies between the two methods were resolved by using the API system, E-test or microbroth dilution. Results ID with the direct method was correct for 95.2% of all tested Enterobacteriaceae (n = 42 and 71.4% of Pseudomonas aeruginosa strains (n = 7. AST with the direct method showed a categorical agreement for Gram-negative rods (GNR of 99.0%, with 0.7% minor errors, 0.3% very major errors and no major errors. All antibiotics showed an agreement of >95%. The direct method for AST of Staphylococcus (n = 81 and Enterococcus (n = 3 species showed a categorical agreement of 95.4%, with a minor error rate of 1.1%, a major error rate of 3.1% and a very major error rate of 0.4%. All antibiotics showed an agreement of >90%, except for trimethoprim-sulfamethoxazole and erythromycin. Conclusions Inoculation of Phoenix panels directly from positive blood cultures can be used to report reliable results of AST of GNR a day earlier, as well as ID-results of Enterobacteriaceae. For Staphylococcus and Enterococcus species, results of AST can also be reported a day earlier for all antibiotics, except for erythromycin and trimethoprim-sulfamethoxazole.

  4. Increased Activity or Energy as a Primary Criterion for the Diagnosis of Bipolar Mania in DSM-5: Findings From the STEP-BD Study

    Science.gov (United States)

    Machado-Vieira, Rodrigo; Luckenbaugh, David A.; Ballard, Elizabeth D.; Henter, Ioline D.; Tohen, Mauricio; Suppes, Trisha; Zarate, Carlos A.

    2016-01-01

    Objective DSM-5 describes “a distinct period of abnormally and persistently elevated, expansive, or irritable mood and abnormally and persistently increased activity or energy” as a primary criterion for mania. Thus, increased energy or activity is now considered a core symptom of manic and hypomanic episodes. Using data from the Systematic Treatment Enhancement Program for Bipolar Disorder study, the authors analyzed point prevalence data obtained at the initial visit to assess the diagnostic validity of this new DSM-5 criterion. The study hypothesis was that the DSM-5 criterion would alter the prevalence of mania and/or hypomania. Method The authors compared prevalence, clinical characteristics, validators, and outcome in patients meeting the DSM-5 criteria (i.e., DSM-IV criteria plus the DSM-5 criterion of increased activity or energy) and those who did not meet the new DSM-5 criterion (i.e., who only met DSM-IV criteria). Results All 4,360 participants met DSM-IV criteria for bipolar disorder, and 310 met DSM-IV criteria for a manic or hypomanic episode. When the new DSM-5 criterion of increased activity or energy was added as a coprimary symptom, the prevalence of mania and hypomania was reduced. Although minor differences were noted in clinical and concurrent validators, no changes were observed in longitudinal outcomes. Conclusions The findings confirm that including increased activity or energy as part of DSM-5 criterion A decreases the prevalence of manic and hypomanic episodes but does not affect longitudinal clinical outcomes. PMID:27523498

  5. Raimbaut de Vaqueiras, “Era·m requier sa costum’e son us” (BdT 392.2

    Directory of Open Access Journals (Sweden)

    Federico Saviotti

    2013-01-01

    Full Text Available The lack of studies on the more traditional love songs composed by Raimbaut de Vaqueiras, compared with the great success of his more experimental poems amongst scholars, has been repeatedly stigmatized. This paper offers a global and detailed reading of a ‘canso’ which is emblematic in the troubadour’s poetry. The vocabulary and stylistic features have been analyzed comparatively in order to correct an erroneous interpretation based on the story told by the ‘razo’ and to recognize the poem’s importance within Raimbaut’s production. This poem, no less than others by the same poet, reveals the most significant marks of its author’s poetic spirit: his curiosity towards reality and his receptiveness. A new critical edition of the text is provided here, based on the revision and a more extensive study of the manuscript tradition.

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  15. Emission control measures for precursors of tropospheric ozone. Pt. 1 and 2; Emissionsminderungsmoeglichkeiten bei Vorlaeufersubstanzen von bodennahem Ozon. Bd. 1: Systemanalyse der Ozonminderungsmassnahmen in den USA. Bd. 2: Luftreinhaltemassnahmen in den USA zur Minderung von VOC-Emissionen aus Kleinanlagen und Produkten und Vergleich mit europaeischen Regelungen

    Energy Technology Data Exchange (ETDEWEB)

    Leclaire, T.; Schiefer, C.; Bergmann, S.; Hrabovski, Z. [Institut fuer Umwelttechnologie und Umweltanalytik e.V. (IUTA), Duisburg (Germany)

    1998-08-01

    For more than two decades now experiences of ozone reduction have been made in the USA. In many regions great efforts for VOC control are made to reduce their high ozone concentrations in ambient air that in some cases reach up to more than twice the German peak concentrations. This report places focus on small stationary sources and products, for these sources actually contribute more than half of the VOC emissions in Germany and are still not regulated under the German Immission Control Law. Therefore, main aim of this examination was to determine the major elements of VOC control strategies in the U.S. and to consider, whether strategies and measures are transferable taking into account German circumstances. Volume 1 describes the strategies and measures for ozone control in the U.S. (national) as well as in five regions with high ozone concentrations in ambient air. The authorities and responsbilities at federal, state, regional, and local levels are highlighted, legislation and different types of regulations are explained, priorities concerning VOC versus NO{sub x} related control are mentioned and the control measures on different sources for reducing VOC and NO{sub x} are summarized briefly. Volume 2 contains a detailed description of control measures for reducing VOC emissions from products and stationary sources, namely the proposed national VOC emission standards for coatings and consumer products, the California Consumer Products Regulations, the state-wide requirements for industrial and commercial sources in California and the VOC related rules of the South Coast Air Quality Management District (LA and surrounded Countries). The South Coast Rules were chosen as an example for District Rules for they were generally the most stringent because of the extreme ozone concentration in this area. Moreover, the regulations for VOC emission control in Europe concerning small stationary sources and products are mentioned. The different approaches to control VOC emissions are compared and discussed. Advantages and disadvantages of the described strategies are highlighted. Based on the actual VOC emission inventory of Germany suggestions for future reduction measures are supposed. (orig.) [Deutsch] In den USA liegen Erfahrungen aus der Ozonbekaempfung ueber einen Zeitraum von 20 bis 30 Jahren vor. Aufgrund besonders hoher Ozonbelastungen in vielen Regionen werden grosse Anstrengungen zur VOC-Minderung unternommen. Wesentliches Ziel des Vorhabens war es, die Schwerpunkt im Hinblick auf die Minderung von VOC-Emissionen herauzufinden und zu pruefen, ob und inwieweit eine Uebertragung von Strategien und Massnahmen auf die Verhaeltnisse in Deutschland moeglich ist. Hauptaugenmerk wurde auf kleinere Anlagen und Produkte gelegt, weil in diesen Bereichen in Deutschland momentan vordringlich Handlungsbedarf gesehen wird. Im ersten Band sind die Strategien und Massnahmen zur Ozonminderung in den USA (bundesweit) sowie in fuenf Regionen mit besonders hoher Ozonimmissionsbelastung beschrieben. Hierzu erfolgte eine Darstellung der Zustaendigkeitsbereiche auf nationaler, einzelstaatlicher, regionaler und lokaler Ebene, der Gesetzgebung und Regelwerke, der Schwerpunktsetzung hinsichtlich NO{sub x}- und VOC-Minderung und eine kurze Darstellung der quellenbezogenen Massnahmen auf nationaler Ebene und in den betrachteten Regionen. In Band 2 erfolgt eine ausfuehrliche Beschreibung der Massnahmen zur VOC-Emissionsminderung bei Produkten und im gewerblichen Bereich in den USA anhand der nationalen Regelungen fuer Anstrichstoffe und Konsumgueter, der von der kalifornischen Luftreinhaltebehoerde erlassenen VOC-bezogenen Regelungen fuer Anstrichstoffe, Konsumgueter und Gewerbebetriebe sowie der Regelungen des suedkalifornischen South Coast Air Quality Management Districts (Los Angeles und Umgebung). Zur Darstellung der regionalen Bestimmung wurde diese Region ausgewaehlt, da die Regelungen dort aufgrund der besonders hohen Immissionsbelastung grundsaetzlich am weitesten gehen. Darueber hinaus werden die Regelungen zur VOC-Emissionsminderung fue

  16. Sordello, “Toz hom me van disen en esta maladia” (BdT 114a.1; Carlo d’Angiò, “Sordels diz mal de mi, e far no lo·m deuria” (BdT 437.37

    Directory of Open Access Journals (Sweden)

    Antonio Petrossi

    2009-10-01

    Full Text Available The paper provides a new commentary and a new edition of the brief exchange of coblas between Sordello and an unidentified respondent. The text is copied on folio 65r of Chansonnier P at the end of a long section of ‘coblas esparsas’ (ff. 55-66. It is made up of two stanzas of six lines each and from the thematic viewpoint offers a lament for the disappearance of a lord’s generosity. Although the text is rather marginal to Sordello’s lyric production, it nevertheless contains elements that are relevant to understanding the troubadour’s life and works. The poem, in fact, represents a literary transfiguration of the rift between Sordello and his respondent, identified as Charles I of Anjou, a rift that occurred after the conquest of the Kingdom of Sicily, when the king completed his plan to go beyond an ideological framework based on a courtly and chivalric outlook, of which the troubadour was the best representative at the time.

  17. Emission control measures for precursors of tropospheric ozone. Pt. 1 and 2; Emissionsminderungsmoeglichkeiten bei Vorlaeufersubstanzen von bodennahem Ozon. Bd. 1: Systemanalyse der Ozonminderungsmassnahmen in den USA. Bd. 2: Luftreinhaltemassnahmen in den USA zur Minderung von VOC-Emissionen aus Kleinanlagen und Produkten und Vergleich mit europaeischen Regelungen

    Energy Technology Data Exchange (ETDEWEB)

    Leclaire, T.; Schiefer, C.; Bergmann, S.; Hrabovski, Z. [Institut fuer Umwelttechnologie und Umweltanalytik e.V. (IUTA), Duisburg (Germany)

    1998-08-01

    For more than two decades now experiences of ozone reduction have been made in the USA. In many regions great efforts for VOC control are made to reduce their high ozone concentrations in ambient air that in some cases reach up to more than twice the German peak concentrations. This report places focus on small stationary sources and products, for these sources actually contribute more than half of the VOC emissions in Germany and are still not regulated under the German Immission Control Law. Therefore, main aim of this examination was to determine the major elements of VOC control strategies in the U.S. and to consider, whether strategies and measures are transferable taking into account German circumstances. Volume 1 describes the strategies and measures for ozone control in the U.S. (national) as well as in five regions with high ozone concentrations in ambient air. The authorities and responsbilities at federal, state, regional, and local levels are highlighted, legislation and different types of regulations are explained, priorities concerning VOC versus NO{sub x} related control are mentioned and the control measures on different sources for reducing VOC and NO{sub x} are summarized briefly. Volume 2 contains a detailed description of control measures for reducing VOC emissions from products and stationary sources, namely the proposed national VOC emission standards for coatings and consumer products, the California Consumer Products Regulations, the state-wide requirements for industrial and commercial sources in California and the VOC related rules of the South Coast Air Quality Management District (LA and surrounded Countries). The South Coast Rules were chosen as an example for District Rules for they were generally the most stringent because of the extreme ozone concentration in this area. Moreover, the regulations for VOC emission control in Europe concerning small stationary sources and products are mentioned. The different approaches to control VOC emissions are compared and discussed. Advantages and disadvantages of the described strategies are highlighted. Based on the actual VOC emission inventory of Germany suggestions for future reduction measures are supposed. (orig.) [Deutsch] In den USA liegen Erfahrungen aus der Ozonbekaempfung ueber einen Zeitraum von 20 bis 30 Jahren vor. Aufgrund besonders hoher Ozonbelastungen in vielen Regionen werden grosse Anstrengungen zur VOC-Minderung unternommen. Wesentliches Ziel des Vorhabens war es, die Schwerpunkt im Hinblick auf die Minderung von VOC-Emissionen herauzufinden und zu pruefen, ob und inwieweit eine Uebertragung von Strategien und Massnahmen auf die Verhaeltnisse in Deutschland moeglich ist. Hauptaugenmerk wurde auf kleinere Anlagen und Produkte gelegt, weil in diesen Bereichen in Deutschland momentan vordringlich Handlungsbedarf gesehen wird. Im ersten Band sind die Strategien und Massnahmen zur Ozonminderung in den USA (bundesweit) sowie in fuenf Regionen mit besonders hoher Ozonimmissionsbelastung beschrieben. Hierzu erfolgte eine Darstellung der Zustaendigkeitsbereiche auf nationaler, einzelstaatlicher, regionaler und lokaler Ebene, der Gesetzgebung und Regelwerke, der Schwerpunktsetzung hinsichtlich NO{sub x}- und VOC-Minderung und eine kurze Darstellung der quellenbezogenen Massnahmen auf nationaler Ebene und in den betrachteten Regionen. In Band 2 erfolgt eine ausfuehrliche Beschreibung der Massnahmen zur VOC-Emissionsminderung bei Produkten und im gewerblichen Bereich in den USA anhand der nationalen Regelungen fuer Anstrichstoffe und Konsumgueter, der von der kalifornischen Luftreinhaltebehoerde erlassenen VOC-bezogenen Regelungen fuer Anstrichstoffe, Konsumgueter und Gewerbebetriebe sowie der Regelungen des suedkalifornischen South Coast Air Quality Management Districts (Los Angeles und Umgebung). Zur Darstellung der regionalen Bestimmung wurde diese Region ausgewaehlt, da die Regelungen dort aufgrund der besonders hohen Immissionsbelastung grundsaetzlich am weitesten gehen. Darueber hinaus werden die Regelungen zur VOC-Emissionsminderung fuer den Bereich der Kleinanlagen und Produkte in Europa dargestellt. Die unterschiedlichen Ansaetze zur VOC-Emissionsminderung werden zusammenfassend diskutiert, Vor-und Nachteile herausgearbeitet und unter Beruecksichtigung der derzeitigen VOC-Emissionssituation in Deutschland Ansatzpunkte fuer zukuenftige Massnahmenschwerpunkte aufgezeigt. (orig.)

  18. 纳米制备与表征%Nanoscale Fabrication and Characterisation

    Institute of Scientific and Technical Information of China (English)

    郭全民

    2003-01-01

    @@ Are there great things to be discovered at the nanoscale? The answer is almost certainly"yes".From the microscale to the nanoscale,it is far from just scaling down,it is a "great leap forward"into a complete new regime where the physical and chemical properties of materials exhibit size dependent behaviour.A thorough understanding of the new physics and chemistry at the nanometer scale will lead to the design and fabrication of smart new functional materials and devices, for instance,electronic devices that operate on the basic principles of quantum mechanics.Nanofabrication will not go far without reliable measurement and characterisation methods.Indeed,the boom in nanotechnology all started when the scanning tunnelling microscopy (STM) was invented in 1982, which enabled surface imagning with atomic resolution.

  19. Dicty_cDB: SFG336 [Dicty_cDB

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  20. Social cognition in patients with schizophrenia spectrum and bipolar disorders with and without psychotic features

    Directory of Open Access Journals (Sweden)

    George C. Nitzburg

    2015-03-01

    Conclusions: MSCEIT deficits were found in SSD but not BD− or BD+, suggesting that social cognition may represent an underlying difference between SSD and BD. However, variance in MSCEIT performance among BD patients may also suggest latent BD subgroups characterized by social-cognitive deficits. Findings can help inform future investigations into how social cognition and social brain development differ between SSD and BD.

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  19. Dicty_cDB: VHC494 [Dicty_cDB

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    Full Text Available Patent EP1598422. 62 2e-14 4 BD092935 |BD092935.1 Methods and compositions for synthesis of long chain polyu...nsaturated fatty acids in plants. 62 2e-14 4 BD082645 |BD082645.1 Methods and compositions for synthesis of ...long chain polyunsaturated fatty acids. 62 2e-14 4 BD082630 |BD082630.1 Methods and composition

  20. Environmental Studies of Macrozoobenthos, Aquatic Macrophytes, and Juvenile Fishes in the St. Clair-Detroit River System, 1983-1984

    Science.gov (United States)

    1986-02-01

    BB cc 1 B B O B O B O OB jB ) B 0) w D BD BD BD BD BD BD BD BD BDBD BDI I - II3BI BI BID BID BID BID ID ID ID lD BDBC BI 8 a 0 0 8i c; a S0 a * a ’ a a...I FF F $-CLARE C.V. C.CCCl C.C!Sif tPCCT PSE ’iccr era PVEIN 1 .9@46?f 1It.C1C8 Copy CVi’h to~ DTTC dos" m4 PsflnlU lully legtia xopioduogst ANALYSIS

  1. Dicty_cDB: Contig-U15817-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available t WO2005083429. 46 5.9 1 ( CQ889410 ) Sequence 67 from Patent EP1466988. 46 5.9 1 ( BD396368 ) Engulfment Genes and Uses... Thereof. 46 5.9 1 ( BD396367 ) Engulfment Genes and Uses Thereof. 46... 5.9 1 ( BD396366 ) Engulfment Genes and Uses Thereof. 46 5.9 1 ( BD396365 ) Engulfment Genes and Uses There...of. 46 5.9 1 ( BD396364 ) Engulfment Genes and Uses Thereof. 46 5.9 1 ( BD396343 ) Engulfment Genes and Uses... Thereof. 46 5.9 1 ( BD396324 ) Engulfment Genes and Uses Thereof. 46 5.9 1 ( BD3

  2. Metal accumulation in human tissues. Vol. 6. Chromium, nickel, lead, cadmium, and zinc in liver, lungs, spleen, and kidneys. Metallanreicherungen in Humangeweben. Bd. 6. Chrom, Nickel, Blei, Cadmium und Zink in Lunge, Leber, Milz und Niere

    Energy Technology Data Exchange (ETDEWEB)

    Kollmeier, H.; Seemann, J.; Wittig, P.; Witting, C.; Rothe, G.

    1985-01-01

    This paper presents the results of the analytical determination of Cr, Ni, Pb, Cd, and Zn in human lungs, livers, spleens, and kidneys by means of flameless atomic absorption spectrometry, and this on an individual and on a group basis; individually as a combined record which contains the trace metal concentrations of the investigated tissues and the post-mortem findings obtained by autopsy. The retrieval of the findings in case of certain diseases is realized by an index. The tissue concentrations of those metals depend upon many endogenous and exogenous variables, especially as regards time and place. Thus, often interpretations are only possible on an individual basis. For example, we measured an increased tissue concentration of lead in a cadaver which perinatally died of severe vasal malformations. On the other hand, we found a highly positive correlation between age and chromium and nickel content of lungs, which might be interesting in regard to occupational lung cancer. In relation to our results we tried to establish reference levels. However, the interpretation of the measurements remains difficult. Within the scientific literature the results of such studies are very different, and this both in regard to the analytical method used and to the year of publication. This fact is demonstrated by tabular overviews of the investigated metals and tissues. Furthermore, problems of organisation of getting samples, of avoiding sample contamination, of quality assurance etc. are discussed.

  3. A common variant of staphylococcal cassette chromosome mec type IVa in isolates from Copenhagen, Denmark, is not detected by the BD GeneOhm methicillin-resistant Staphylococcus aureus assay

    DEFF Research Database (Denmark)

    Bartels, Mette Damkjaer; Boye, Kit; Rohde, Susanne Mie

    2009-01-01

    -susceptible Staphylococcus aureus isolates were included as negative controls. Forty-four MRSA isolates were undetectable; of these, 95% harbored SCCmec type IVa, and these included the most-common clone in Copenhagen, spa t024-sequence type 8-IVa. The false-negative MRSA isolates were tested with new primers (analyte...

  4. Carrier tracking of high dynamic BD satellite signal based on UPF%基于UPF的高动态北斗卫星信号的载波跟踪

    Institute of Scientific and Technical Information of China (English)

    王海辉; 孙希延; 纪元法

    2015-01-01

    In order to improve the tracking accuracy of extended Kalman filter and unscented Kalman filter and other high dy-namic signal carrier tracking algorithms,the unscented particle filter is used for tracking the high dynamic Beidou satellite signal carrier.The UPF algorithm combines particle filter with unscented Kalman filter,the carrier state variables are esti-mated by particle filter,and to solve the problem of particle degradation,the UKF filter is used to redistribute the weight of particles.Matlab simulation results show that the carrier frequency offsets of EKF,UKF and UPF tracking algorithms are respectively -15-15,-10-10,-4-4 Hz,the superiority of UPF algorithm is proved.%针对扩展卡尔曼滤波(EKF)和无迹卡尔曼滤波(UKF)等高动态信号载波跟踪算法存在跟踪精度不高的问题,采用无迹粒子滤波(UPF)算法对高动态北斗卫星信号载波进行跟踪。UPF 算法结合粒子滤波(PF)和无迹卡尔曼滤波,采用PF对载波状态变量进行估计,同时使用 UKF滤波器对粒子进行权值的重新分配,解决了粒子退化问题。通过 Matlab 仿真对比,基于 EKF、UKF、UPF的跟踪算法的载波频率误差分别为-15~15、-10~10、-4~4 Hz,验证了 UPF算法的优越性。

  5. Determination and calculation of hazardous incident scenarios in accordance with the 3rd hazardous incident administrative instruction. Vol. 1; Ermittlung und Berechnung von Stoerfallablaufszenarien nach Massgabe der 3. Stoerfallverwaltungsvorschrift. Bd. 1: Methodischer Teil zum Erarbeiten von Stoerfallablaufszenarien

    Energy Technology Data Exchange (ETDEWEB)

    Kaiser, W.; Rogazewski, P.; Schindler, M. [TUeV Anlagentechnik GmbH, Berlin-Schoeneberg (Germany). Unternehmensgruppe TUeV Rheinland/Berlin-Brandenburg; Acikalin, A.; Albrecht, M.; Lambert, M.; Steinbach, J. [Technische Univ. Berlin (Germany)

    2000-07-01

    At present there are used various procedures, calculation methods, models and model equations for hazardous incident scenarios. The procedure on principle is varying often. This guideline explains in one main part and six appendixes the methodical procedure to select specifications and assumptions on hazardous incident scenarios and their processing. Hazardous incident scenarios lead to information on emergency preparedness planning. Both general viewpoints and possibilities are shown, how to find necessary basic assumptions on a hazardous incident scenario from information on hazardous substances, on comparable hazardous incidents and on conditions of the site and the plant. Appendixes deal with precise instructions distinguished between substance release, explosion and fire (App. 1: Assessment of source terms, App. 2: Assessment of dispersion, App. 3: Assessment of effects). Appendix 4 gives explanations to appendixes 1, 2 and 3. Appendix 5 contains a collection of 15 examples of hazardous incident scenarios, which illustrate and comment the methodical procedure. Appendix 6 describes and comments software available on German market which assists the calculating of hazardous incidents. Volume 2 determines procedures with regard to methods of calculation, current models and model equations from scientists' point of view. (orig.) [German] Derzeit wird eine Vielzahl von Vorgehensweisen, Berechnungsmethoden, Modellen und Modellgleichungen fuer Stoerfallablaufszenarien verwendet. Das prinzipielle Vorgehen ist haeufig unterschiedlich. Dieser Leitfaden enthaelt in einem Hauptteil und sechs Anhaengen das methodische Vorgehen zur Auswahl von Angaben und Annahmen fuer Stoerfallablaufszenarien sowie deren Bearbeitung. Stoerfallablaufszenarien fuehren zu Angaben fuer die Gefahrenabwehrplanung. Fuer das Ableiten von Stoerfallablaufszenarien sind sowohl allgemeine Gesichtspunkte als auch Moeglichkeiten dargelegt, wie man aus Angaben zu Gefahrstoffen, zu vergleichbaren Stoerfaellen sowie zu Bedingungen des Standortes und der Anlage die erforderlichen Grundannahmen zum Stoerfallablauf gewinnen kann. Unterschieden nach Stofffreisetzungen, Explosionen und Braenden wird jeweils auf die konkreteren Hinweise im Anhang 1 zur Abschaetzung von Quelltermen, im Anhang 2 zur Abschaetzung der Ausbreitung und im Anhang 3 zur Abschaetzung der Auswirkungen verwiesen. Der Anhang 4 enthaelt einige Erlaeuterungen zu den Anhaengen 1 bis 3. Mit einer Sammlung von 15 Beispielen fuer Stoerfallablaufszenarien wird im Anhang 5 das im Leitfaden beschriebene methodische Vorgehen veranschaulicht und erlaeutert. Im Anhang 6 werden die auf dem deutschen Markt erhaeltlichen DV-Programme (Software) zur Berechnung von Stoerfallablaufszenarien beschrieben und kommentiert. Der Band 2 untermauert das Vorgehen im Hinblick auf Berechnungsmethoden, aktuelle Modelle und Modellgleichungen aus wissenschaftlicher Sicht. (orig.)

  6. Determination and calculation of hazardous incident scenarios in accordance with the 3rd hazardous incident administrative instruction. Vol. 2; Ermittlung und Berechnung von Stoerfallablaufszenarien nach Massgabe der 3. Stoerfallverwaltungsvorschrift. Bd. 2: Berechnungsmethoden, aktuelle Modelle und Modellgleichungen

    Energy Technology Data Exchange (ETDEWEB)

    Kaiser, W.; Rogazewski, P.; Schindler, M. [TUeV Anlagentechnik GmbH, Berlin-Schoeneberg (Germany). Unternehmensgruppe TUeV Rheinland/Berlin-Brandenburg; Acikalin, A.; Albrecht, M.; Lambert, M.; Steinbach, J. [Technische Univ. Berlin (Germany)

    2000-07-01

    At present there are used various of procedures, calculation methods, models and model equations for hazardous incident scenarios. The procedure on principle is varying often. This guideline explains in one main part and six appendixes the methodical procedure to select specifications and assumptions on hazardous incident scenarios and their processing. Hazardous incident scenarios lead to information on emergency preparedness planning. Both general viewpoints and possibilities are shown, how to find necessary basic assumptions on a hazardous incident scenario from information on hazardous substances, on comparable hazardous incidents and on conditions of the site and the plant. Appendixes deal with precise instructions distinguished between substance release, explosion and fire (app. 1: Assessment of source terms, app. 2: Assessment of dispersion, app. 3: Assessment of effects). Appendix 4 gives explanations to appendixes 1, 2 and 3. Appendix 5 contains a collection of 15 examples of hazardous incident scenarios, which illustrate and comment the methodical procedure. Appendix 6 describes and comments software available on German market which assists the calculating of hazardous incidents. Volume 2 determines procedures with regard to methods of calculation, current models and model equations from scientists point of view. (orig.) [German] Derzeit wird eine Vielzahl von Vorgehensweisen, Berechnungsmethoden, Modellen und Modellgleichungen fuer Stoerfallablaufszenarien verwendet. Das prinzipielle Vorgehen ist haeufig unterschiedlich. Dieser Leitfaden enthaelt in einem Hauptteil und sechs Anhaengen das methodische Vorgehen zur Auswahl von Angaben und Annahmen fuer Stoerfallablaufszenarien sowie deren Bearbeitung. Stoerfallablaufszenarien fuehren zu Angaben fuer die Gefahrenabwehrplanung. Fuer das Ableiten von Stoerfallablaufszenarien sind sowohl allgemeine Gesichtspunkte als auch Moeglichkeiten dargelegt, wie man aus Angaben zu Gefahrstoffen, zu vergleichbaren Stoerfaellen sowie zu Bedingungen des Standortes und der Anlage die erforderlichen Grundannahmen zum Stoerfallablauf gewinnen kann. Unterschieden nach Stofffreisetzungen, Explosionen und Braenden wird jeweils auf die konkreteren Hinweise im Anhang 1 zur Abschaetzung von Quelltermen, im Anhang 2 zur Abschaetzung der Ausbreitung und im Anhang 3 zur Abschaetzung der Auswirkungen verwiesen. Der Anhang 4 enthaelt einige Erlaeuterungen zu den Anhaengen 1 bis 3. Mit einer Sammlung von 15 Beispielen fuer Stoerfallablaufszenarien wird im Anhang 5 das im Leitfaden beschriebene methodische Vorgehen veranschaulicht und erlaeutert. Im Anhang 6 werden die auf dem deutschen Markt erhaeltlichen DV-Programme (Software) zur Berechnung von Stoerfallablaufszenarien beschrieben und kommentiert. Der Band 2 untermauert das Vorgehen im Hinblick auf Berechnungsmethoden, aktuelle Modelle und Modellgleichungen aus wissenschaftlicher Sicht. (orig.)

  7. Influence of environmental temperature and preheating time on B-D test%环境温度和预热时间对B-D测试的影响

    Institute of Scientific and Technical Information of China (English)

    余正香

    2006-01-01

    B-D测试(Bowie-Dick test),是1963年由苏格兰两位微生物学家Bowie和Dick设计的,专门用于检测真空型(包括预真空和脉动真空)压力蒸汽灭菌器冷空气排除的效果,而冷空气是造成真空型压力蒸汽灭菌器灭菌失败的主要因素之一。真空型灭菌器排除冷空气失败的原因除灭菌器本身的故障外,主要因素是空气起始温度低,重力作用明显。笔者在这方面作了观察,现报告如下。

  8. 影响 B-D测试结果相关因素及处理对策%About correlation factor and management strategy to influence B-D test result

    Institute of Scientific and Technical Information of China (English)

    温建芳

    2008-01-01

    @@ B-D测试于1963年由两位苏格兰微生物学家Bowie和J Dick设计,主要用于评价预真空(脉动真空)压力蒸汽灭菌器冷空气排除效果、饱和蒸汽穿透、漏气和不可压缩空气的存在等灭菌器方面的性能.我国和对高压蒸汽灭菌器均要求每日进行一次B-D试验.但因设备、技术操作和监测用品质量管理等因素,可直接影响B-D试验结果.因此,了解导致B-D测试失败的相关因素和处理对策,对提高B-D试验的成功率和保证灭菌质量具有一定指导意义.

  9. Liens économiques, contagion, et la crise financière. Synthèse de la conférence BdF/PSE/FMI des 28 et 29 janvier 2010.

    OpenAIRE

    Bussière, M

    2010-01-01

    La crise financière a durablement transformé l’environnement économique mondial et stimulé de nombreuses études sur ses causes et ses canaux de transmission, qui ont été présentées lors d’une conférence organisée par la Banque de France, PSE et le FMI.

  10. Mictrostructured sensor systems for chemical gas analysis - 'MISCHGAS'. Vol. 1: Reports 1 - 6. Final report; Mikrostrukturierte Sensorsysteme fuer die chemische Gasanalyse - 'MISCHGAS'. Bd. 1: Teilberichte 1 - 6. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-07-01

    The project MISCHGAS was aimed at low-power microstructured multisensor systems for analyses of complex gas mixtures. This comprised 1. the development of the sensor chip (sensor layout, sandwich sensor systems, ultrathin carrier materials, and sol-gel technologies), 2. investigation of atomistic and electrical sensor mechanism, 3. design and construction (glues, materials, noble metal free contact systems), 4. generation and reading of the sensor signal, 5. investigation of the analytical properties of the sensors, 6. user-oriented specialised gas analysis systems. [German] Ziel des Projektes MISCHGAS sind leistungsarme, mikrostrukturierte, multisensor-geeignete Systeme fuer die Analyse sowohl einzelner als auch mehrerer Kompoenten komplexer Gasgemische. Dazu wurden die notwendigen Teilbereiche: technologische Entwicklungen des Sensorchips, Klaerung atomistischer sowie elektrischer Sensormechanismen, Aufbau und Verbindungstechnik, Generierung und Auslesung des Sensorsignals, Ermittlung der analytischen Eigenschaften der Sensoren, anwenderorientierte spezialisierte Gasmesssysteme von den Verbundpartnern bearbeitet. Hauptpunkte neuer technologischer Entwicklungen waren Sensorlayout, Sensorschichtsysteme sowie ultraduenne Traegermaterialien ueber die 'porous silicon sacrificial layer'-Technik sowie Sol-Gel-Technologien. Damit konnten leistungsarme Traeger hergestellt werden. Materialien waren SnO{sub 2} und V{sub 2}O{sub 5}. Der Einfluss von Pt auf die Sensorreaktion konnte beschrieben werden. Das Verstaendnis phaenomenologischer Zusammenhaenge von Sensormechanismen und deren physikalisch-chemisch-analytischer Erfassung sowie der festkoerperphysikalischen Beschreibung wurde deutlich verbessert. Technologie und Prozesstechnik wurden auf Gesichtspunkte wie Qualitaetssicherung, und Transferierbarkeit ausgerichtet. Weitere Arbeitsbereiche sind die Gehaeuseentwicklung und Fixierung im Gehaeuse. In der AVT gab es Fortschritte bei Kleber und Aufbauhilfsstoffen sowie edelmetallfreien Kontaktsystemen. Fuer technische Einsatzbedingungen wurden entsprechende Filter weiterentwickelt. Weitere Fortschritte gab es im Bereich Sensormesstechnik. Alle Verbundpartner wurden mit den jeweils aktuellen technologischen Sensorqualitaeten fuer ihre Qualifizierungsmessungen versorgt. Durch eine Standardisierung des Messprotokolls wurde eine Vergleichbarkeit der Qualifizierungsergebnisse ermoeglicht. Um die Aussagefaehigkeit der Sensoren weiter auszunutzen, wurde der Thermopulsbetrieb als Messmethode ausgebaut. Dies ermoeglicht es u.a., die temperaturabhaengige Empfindlichkeit eines Sensors zu nutzen und kann einen Beitrag zur Verringerung der Leistungsaufnahme des Sensors leisten. Abhaengig vom Anwendungsfall evaluierten Verbundpartner in Pilotsystemen die technologischen Entwicklungen. Dies gilt insbesondere fuer die Bereiche Brandfrueherkennung und Rauchgaserkennung. (orig.)

  11. In-situ sanitation of hydrocarbon polluted soils. Vol. 2. Subordinate project: Microbial studies on hydrocarbon degradation. Final report; In-Situ-Sanierung kohlenwasserstoffbelasteter Boeden. Bd. 2. Teilprojekt: Mikrobiologische Untersuchungen zum Kohlenwasserstoffabbau. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Pommeranz, S.; Boldrin, B.; Tiehm, A.; Zipperle, J.; Fritzsche, C.; Zumft, W.

    1993-09-01

    One aim of the subproject at the department of microbiology was to identify microorganisms capable of degrading components of soil pollutants typically emitted by gas works. Binuclear, trinuclear, and tetranuclear polycyclic aromatic hydrocarbons (PAH) were used as test substances, namely naphthaliene, phenanthrene, fluorene, anthracene, fluoranthene, and pyrene. The results show that there are numerous and diverse competent microbial species in the soil of the gas works premises in the east of Karlsruhe. Of the 23 soil samples examined 20 contained PAH degrading microorganisms. Of the 355 isolates tested individually 168 degraded naphthalene, 34 enthracene, 37 fluorene, 25 fluoranthene, and 5 pyrene. Competent pure and mixed cultures were isolated for each of the model substances used. This shows that the antochtonous populations have adapted to the conditions after the accident and that the soil contains PAH degrading microorganisms (70% of isolates in a sample). The PAH degrading bacteria belong to different species: many were identified as pseudomonas sp., but alcaligues sp., acinetobacter sp. and myobacterium sp. were also found. (orig./EF) [Deutsch] Ein Schwerpunkt des Teilprojektes am Lehrstuhl fuer Mikrobiologie war die Erfassung der Mikroorganismen, die Komponenten von gaswerksspezifischen Bodenkontaminationen abbauen koennen. Als Leitsubstanzen wurden die 2-, 3-, und 4-kernigen polyzyklischen aromatischen Kohlenwasserstoffe (PAK) Naphthalin, Phenanthren, Fluoren, Anthracen, Fluoranthen und Pyren ausgewaehlt. Die Ergebnisse zeigen deutlich die hohe Anzahl und Diversitaet kompetenter Mikroorganismen im Boden des ehemaligen Gaswerksgelaendes Karlsruhe-Ost. Insgesamt wurden in 20 von 23 untersuchten Bodenproben PAK-verwertende Mikroorganismen nachgewiesen. Von 355 einzeln getesteten Isolaten verwerteten 168 Naphthalin, 163 Phenanthren, 34 Anthracen, 37 Fluoren, 25 Fluoranthen und 5 Pyren. Fuer jede verwendete Modellsubstanz wurden kompetente Misch- und Reinkulturen isoliert. Dies zeigte, dass sich die autochthonen Populationen an den Schadensfall angepasst haben und PAK-verwertende Mikroorganismen im Boden vorhanden waren (bis zu 70% aller Isolate einer Probe). Die PAK-verwertenden Bakterien gehoerten zu verschiedenen Gattungen: viele wurden als Pseudomonas sp. identifiziert, aber auch Alcaligenes sp., Acinetobacter sp. und Mycobacterium sp. wurden nachgewiesen. (orig./EF)

  12. Analysis and comparison. Bd. 1 - Longlife. Report on the analysis of state of technology, administrative and legal procedures, financial situation, demographic needs, similarities and differences in the participating countries Denmark, Germany, Lithuania, Poland and Russia. Formulations and benchmarks

    Energy Technology Data Exchange (ETDEWEB)

    Rueckert, Klaus (ed.)

    2010-07-01

    Environmental considerations are becoming one of the key features in the design when it comes to constructing modern, sustainable residential buildings. In an effort to streamline procedures and practices, the project Longlife has conducted a comparative review of these among the countries Denmark, Germany, Lithuania, Poland and Russia (associated organizations). The countries involved have shared knowledge and experiences with each other about how their respective building processes operate. These are collated and analysed. There are differences and commonness in the state of technology, administrative and legal procedures, financial situation, demographic needs, and how a 'housing project' functions. With this exercise Longlife has started to ensure that differences across the Baltic Sea Region will be minimised as regards environmentally-friendly residential constructions. This initial comparative stage covers planning, building permit and tendering procedures, practices for developing and operating housing and construction technologies. The report reflects the currently most applicable features of the participating countries' processes. Longlife project partners work in three competence teams to use the special know how and experiences and to cooperate in the public private partnership composition. The report analyses in the competence team 1 - Engineering and building technology, design standards - the engineering and technology standards in the countries Denmark, Germany, Lithuania, Poland and Russia. The report shows for the competence team 2 - Administration procedures, licensing rules, tendering rules, laws - the comparison and investigations of administration procedures, building permit rules, tendering rules and laws in the participating countries. The report provides for competence team 3 - Economical and financial basis - a general and a specific overview about economical and financial issues, sustainability and quality aspects in the involved countries. This report is basis for the next work package: development of standards, criteria and specifications for a sustainable, resource saving residential building. (orig.)

  13. Global and local - air pollution abatement in the 21st century. Seminar No. 14 of Zentrale Informationsstelle Umweltberatung Bayern; Global und Lokal - Klimaschutz fuer das 21. Jahrhundert. Seminarband der Zentralen Informationsstelle Umweltberatung Bayern. Bd. 14

    Energy Technology Data Exchange (ETDEWEB)

    Koller, U.; Behling, G.; Rauh, K.; Haury, H.J. (comps.)

    1999-08-01

    Scientists of Germany's major climate research institutes and an expert of the world climate research programme presented current information on climate trends. They informed on the results of international efforts to prevent global warming after the Buenos Aires conference and presented global climate scenarios of the future. Further issues were local air pollution abatement (energy management, thermal insulation), communal air pollution abatement concepts, and state funding in Bavaria and elsewhere. [German] Wissenschaftler aus den bedeutendsten Instituten deutscher Klimaforschung sowie ein Vertreter des Weltklimaforschungsprogramms stellten aktuelle Erkenntnisse zur Entwicklung unseres Klimas vor. Sie informierten ueber Ergebnisse internationaler Klimaschutzpolitik nach der Klimakonferenz in Buenos Aires und praesentierten Szenarien fuer das globale Klima der Zukunft. Sie widmeten sich ausserdem Fragen des lokalen Klimaschutzes unter den Aspekten Energiemanagement, Waermeschutz und diskutierten ueber kommunale Klimaschutzkonzepte sowie Foerdermoeglichkeiten in und ausserhalb Bayerns. (orig.)

  14. Scenarios for an integrated sustainability policy - using the example of the ''Sustainable City 2030''. Vol. 1; Szenarien fuer eine integrierte Nachhaltigkeitspolitik - am Beispiel: Die nachhaltige Stadt 2030. Bd. 1. Ueberblick und Fazit

    Energy Technology Data Exchange (ETDEWEB)

    Gassner, Robert [Institut fuer Zukunftsstudien und Technologiebewertung gGmbH (IZT), Berlin (Germany)

    2013-04-15

    On behalf of the German Federal Environment Agency, this project was supposed to enhance the further development of an integrated sustainability policy in Germany. Focus of the project was the design of sustainable urban living environments, as everyday life related views of for example citizens, consumers, employees, traffic participants etc. can serve as a consistency check for an integrated sustainability policy. Political topics and stakeholders within the German environment department and beyond were analyzed in order to enhance an effective integrated sustainability policy and to identify potential synergies. For this as well as for the resolution of possible trade-offs a systematic and empirically based scenario process has been used. In the introductory empirical and planning phase the fundamentals were elaborated: Desk research, interviews and workshops were conducted to identify political topics and strategic fields, which then were checked for trade-offs and potential cooperations. For this first phase of the project stakeholders, as well as their motivations and underlying expectations for the future were identified. In the main phase of the project two complementary topics (''Recycling City'' and ''Sustainable Economy in the City'') were jointly selected and elaborated in two parallel conducted systematic and participatory scenario processes to generate integrated images of the future in 2030. Furthermore, options for action, strategic elements and potentials for networking were derived and concretized with regard to practical cooperation in the German Department of the Environment.

  15. Rezension zu: Emilija Mitrović, Dorothea Müller (Hg.: Sexarbeit – ein Beruf mit Interessensvertretung? Working in the sex industry – Jobs with representation of interests? Marburg: BdWi-Verlag 2009.

    Directory of Open Access Journals (Sweden)

    Wiebke Dierkes

    2010-01-01

    Full Text Available Der Band versammelt in internationaler Perspektive die sich teils diametral entgegenstehenden Positionen zur Sexarbeit im Allgemeinen sowie zur Frage der gewerkschaftlichen Interessenvertretung im Besonderen und lässt die Brisanz der Diskussion sowohl im feministischen als auch im arbeits(marktpolitischen Diskurs erkennen. Leider bleibt die Debatte in einem grundsätzlichen Für und Wider verhaftet und vernachlässigt die Diskussion und Evaluation konkreter Bemühungen gewerkschaftlicher Organisierungsstrategien in der Sexindustrie. Zu Wort kommen fast ausschließlich Vertreterinnen von Gewerkschaften oder Organisationen, die Sexarbeiter/-innen unterstützen. Nur zwei Beiträge stammen von Sexarbeiterinnen selbst.

  16. Scientific measurement and evaluation programme (WMEP). Phase 3. Vol. 1 and 2. Final report; Wissenschaftliches Mess- und Evaluierungsprogramm (WMEP) zum Breitentest ''250 MW Wind''. Phase 3. Bd. 1 und 2. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Doepfer, R.; Durstewitz, M.; Ensslin, C. [and others

    2000-07-01

    The Federal Ministry for Economics and Technology (BMWi) funds the '250 MW Wind' test programme. This programme is designed to acquire statistically relevant data concerning the practical use of wind energy converters (WEC) in the Federal Republic of Germany. The technological and scientific areas of this supportive measure, the so called 'Wissenschaftliches Mess- und Evaluierungsprogramm' (WMEP - Scientific Measurement and Evaluation Programme), are implemented by the Institut fuer Solar Energieversorgungstechnik (ISET - Institute for Solar Energy Supply Technology) in Kassel. The WMEP acquires performance data concerning all funded WECs for a ten year period. The final report on hand describes the results of the 3rd project phase (01/07/96 - 30/06/00) of the WMEP including four annual reports and a summary of the most important fields of work. In this phase, for the first time all evaluations could be based upon the complete plant stock since all funded projects were represented in the programme. As of 30/06/00, a total of 1,497 wind turbines with an installed capacity of 349.5 MW at approx. 1,100 different locations are under supervision. During the whole project phase a maximum of 1,557 turbines was supervised. The rated power of the turbines ranges from 2.5 kW up to 1.5 MW. Evaluations regarding the economy, the estimated lifetime and long-term reliability as well as the power performance of widely dispersed wind turbine systems could be initiated in this project phase. It should also be mentioned, that the WMEP evaluations do now include all wind turbines operated in Germany. (orig.) [German] Das Bundesministerium fuer Wirtschaft und Technologie (BMWi) foerdert mit dem Breitentest '250 MW Wind' die Einfuehrung der Windenergienutzung in Deutschland. Zur Gewinnung statistisch relevanter Erfahrungswerte aus dem praktischen Einsatz von Windenergieanlagen (WEA) wurde das Institut fuer Solare Energieversorgungstechnik e.V. (ISET), Kassel, mit der begleitenden Durchfuehrung des 'Wissenschaftlichen Mess- und Evaluierungsprogramms' (WMEP) beauftragt. Im Rahmen dieses Programms werden von allen gefoerderten WEA fuer einen Zeitraum von zehn Jahren ausgewaehlte Betriebsdaten und -ergebnisse erfasst und ausgewertet. Der vorliegende Abschlussbericht beschreibt die Ergebnisse der 3. Durchfuehrungsphase (01.07.1996 - 30.06.2000) des WMEP in vier Jahresberichten und einer Zusammenfassung der wichtigsten Arbeitsschwerpunkte. In der dritten Projektphase konnten erstmals Jahresauswertungen mit dem vollstaendigen Anlagenbestand druchgefuehrt werden, da alle bewilligten Projekte ins WMEP aufgenommen werden konnten. Zum 30.06.2000 betraegt der Anlagenbestand 1497 WEA mit einer installierten Nennleistung von insgesamt 349,5 MW, der an ca. 1.100 unterschiedlichen Standorten installiert ist. Insgesamt wurden im WMEP bis zu 1557 WEA messtechnisch begleitet. Das Leistungsspektrum der einzelnen WEA reicht dabei von 2,5 kW bis 1,5 MW. In der Projektphase III des WMEP standen besonders erste Auswertungen zur Wirtschaftlichkeit, zum Langzeitverhalten sowie zum Leistungsbeitrag der Windenergie im Vordergrund. Besonders hervorzuheben sind noch die ebenfalls in dieser Phase begonnenen Auswertungen zur zeitlichen Entwicklung der Windenergienutzung, die nunmehr alle in Deutschland betriebenen WEA umfassen. (orig.)

  17. Computer science handbook. Vol. 13.3. Environmental computer science. Computer science methods for environmental protection and environmental research; Handbuch der Informatik. Bd. 13.3. Umweltinformatik. Informatikmethoden fuer Umweltschutz und Umweltforschung

    Energy Technology Data Exchange (ETDEWEB)

    Page, B. [ed.] [Hamburg Univ. (Germany). Fachbereich 18 - Informatik; Hilty, L.M. [ed.] [Hamburg Univ. (Germany). Fachbereich 18 - Informatik

    1994-12-31

    Environmental computer science is a new partial discipline of applied computer science, which makes use of methods and techniques of information processing in environmental protection. Thanks to the inter-disciplinary nature of environmental problems, computer science acts as a mediator between numerous disciplines and institutions in this sector. The handbook reflects the broad spectrum of state-of-the art environmental computer science. The following important subjects are dealt with: Environmental databases and information systems, environmental monitoring, modelling and simulation, visualization of environmental data and knowledge-based systems in the environmental sector. (orig.) [Deutsch] Umweltinformatik ist eine neue Teildisziplin der Angewandten Informatik, die Methoden und Techniken der Informationsverarbeitung fuer den Umweltschutz entwickelt und einsetzt. Durch den fachuebergreifenden Charakter der Umweltprobleme faellt der Informatik hier eine Vermittlerrolle zwischen zahlreichen Disziplinen und Institutionen zu. Dieses Handbuch stellt das breite Spektrum der Umweltinformatik auf dem aktuellen Stand der Forschung dar. Wichtige Themen sind Umweltdatenbanken und -informationssysteme, Umweltmonitoring, Modellbildung und Simulation, Visualisierung von Umweltdaten und wissensbasierte Systeme im Umweltbereich. (orig.)

  18. Irradiation programme HFR phase IIb - SPICE. Impact testing on up to 16.3 dpa irradiated RAFM steels. Final report for task TW2-TTMS 001b-D05

    Energy Technology Data Exchange (ETDEWEB)

    Gaganidze, E.; Dafferner, B.; Ries, H.; Rolli, R.; Schneider, H.C.; Aktaa, J.

    2008-04-15

    The objective of this work is to study the effects of neutron irradiation on the embrittlement behavior of different reduced activation ferritic/martensitic (RAFM) steels. The irradiation was carried out in the Petten High Flux Reactor (HFR) in the framework of the HFR Phase IIb (SPICE) irradiation project at a nominal dose of 16.3 dpa and at different irradiation temperatures (250-450 C). The impact properties are investigated by instrumented Charpy-V tests with subsize specimens (KLST-type). The emphasis is put on the investigation of irradiation induced embrittlement and hardening of the European RAFM reference steel for the first wall of a DEMO fusion reactor, EURO- FER97 under different heat treatment conditions. The mechanical properties of EUROFER97 are compared with the results on international reference steels (F82H-mod, OPTIFER-Ia, GA3X and MANET-I) included in the SPICE project. EUROFER97 irradiated up to 16.3 dpa between 250 and 450 C showed irradiation resistance that is comparable to those of best RAFM steels. Large low temperature (T{sub irr} {<=} 300 C) embrittlement is seen for all investigated RAFM steels. Heat treatment of EUROFER97 at higher austenitizing temperature led to the reduction of embrittlement at low temperatures (T{sub irr} {<=} 350 C). At T{sub irr} {>=} 350 C the DBTTs of the steels remain below -20 C and, hence, are well below the application temperature. Analysis of hardening vs. embrittlement behaviour indicated hardening dominated embrittlement at T{sub irr} {<=} 350 C with 0.17 {<=} C{sub 100} {<=} 0.53 C/MPa. Oxygen dispersion hardened ODS EUROFER with 0.5 wt.% Y{sub 2}O{sub 3} has been irradiated at selected irradiation temperatures. ODS EUROFER showed not satisfying impact properties already in the unirradiated condition characterized by low USE = 2.54 J and large DBTT = 135 C. Furthermore, the increase of USE for irradiation temperatures below T{sub irr} {<=} 350 C indicates not optimized fabrication process. At T{sub irr} = 250 C neutron irradiation induced shift in DBTT is comparable to that of the base EUROFER97 steel. At higher irradiation temperatures, however, hipped ODS EUROFER shows larger embrittlement compared to base metal. He embrittlement is investigated in EUROFER97 based steels, that are doped with different contents of natural boron and the separated 10B-isotope (0.008-0.112 wt.%). Boron doped steels show progressive embrittlement and reduction of toughness with increasing helium amount. At T{sub irr} = 250 C helium induced embrittlement is of hardening nature for low helium contents up to 84 appm. Larger helium concentrations lead to non-hardening embrittlement mechanisms beyond that of hardening embrittlement. (orig.)

  19. Climate protection by reducing the emissions of greenhouse gases in households and the tertiary sector through climate-conscious behaviour. Vol. 1; Klimaschutz durch Minderung von Treibhausgasemissionen im Bereich Haushalte und Kleinverbrauch durch klimagerechtes Verhalten. Bd. 1. Private Haushalte

    Energy Technology Data Exchange (ETDEWEB)

    Brohmann, B.; Cames, M.

    2000-06-01

    The aim of the project was to identify areas in households and the tertiary sector in which changes in behaviour could result in energy conservation and thus a reduction of greenhouse gas emissions, and to quantify the potentials for 1995, 2005 and 2020. A second focus was on the analysis and evaluation of programmes and instruments to realise the potentials. With literature evaluation, expert interviews, and a household servey potentials and further technical development have been identified. In sum, behavioural measures can contribute to the CO2 reduction by 64 million tons in 1995 in households and 27 in the commercial sector in which the potential decreases to 18 million tons in 2020 due to the autonomous technical development. Adequate promotion programmes can help to realise 20-30% of the potential by 2020. (orig.) [German] Ziel des Vorhabens war, im Sektor private Haushalte und Kleinverbrauch Bereiche zu identifizieren, in denen Verhaltensaenderungen zur Energieeinsparung fuehren koennen, und diese Potenziale fuer 1995, 2005 und 2020 zu quantifizieren. Darauf aufbauend waren Programme und Instrumente zur Umsetzung aufzuzeigen und zu bewerten. Gestuetzt auf Literaturrecherchen und Expertengespraeche wurden Einzelpotenziale, Rahmenbedingungen, Entwicklungstrends in der Technik und im Ausstattungsgrad ermittelt. Insgesamt koennten Verhaltensmassnahmen im Haushaltssektor die CO2-Emissionen im Basisjahr 1995 um 64 Mio, im Kleinverbrauch um 27 Mio t vermindern. Bis 2020 bleibt dieses Potenzial im Haushaltssektor in etwa gleich. Im Kleinverbrauch sinkt es infolge der autonomen Technikentwicklung auf 18 Mio t ab. Durch geeignete Programme koennen bis 2020 etwa 20-30% des Potenzials erreicht werden. (orig.)

  20. 100eme anniversaire de la théorie de la relativité Une BD romande : Mélanges Einstein (Albert) et l'histoire de la physique

    CERN Multimedia

    Tesnier, Grégory

    2005-01-01

    2005 has been delcared "Year of Physics" by UNESCO and ONU to celebrate the 100th anniversary of the theory of relativity, elaborated by Einstein (who lived in Bern). To hon. Einstein, an historical comic strip has been published (1 page)

  1. Environmental survey 1998. Vol. 3: Human biomonitoring. Concentrations of substances in blood and urine of the German population; Umwelt-Survey 1998. Bd. 3: Human-Biomonitoring. Stoffgehalte in Blut und Urin der Bevoelkerung in Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Becker, K.; Kaus, S.; Krause, C.; Lepom, P.; Schulz, C.; Seiwert, M.; Seifert, B.

    2002-03-01

    The occurrence of precious metals in the environment is increasing, due primarily to their use in catalytic converters for motor vehicles, and they were therefore integrated into the study programme in 1998. Urine samples of 1080 subjects were analysed for gold, platinum and iridium, resulting in mean concentrations of 46 ng/l, 2.2 ng/l and 0.2 ng/l. The number of dental inlays, crowns and bridge elements has a clear influence on the mean levels of gold and platinum in urine. Road traffic was not found to be a signficant factor. Nicotine and cotinine are common markers for exposure to tobacco smoke. Non-smokers exhibit a mean nicotine level in urine of less than 2 {mu}g/l and a cotinine level of less than 4 {mu}gl. Nicotine and cotinine levels in urine increase as a function of the number of cigarettes smoked per day, reaching values of 1080 {mu}g/l and 2060 {mu}g/l, respectively, when consumption exceeds 20 cigarettes per day. Exposure to environmental tobacco smoke is also reflected by nicotine and cotinine levels in urine. The present report provides representative data for environmentally related health monitoring and reporting at national level. The data serve as the basis for the formulation of reference values characterising the population's internal exposure to environmental contaminants. The report shows trends over time and regional differences in pollution, and identifies exposure pathways. The results of the Environmental Survey serve inter alia to achieve nationally harmonised methodologies for assessment, health-related environmental reporting, and the development and monitoring of prevention, intervention and abatement strategies within the scope of health and environmental policy actions. (orig.)

  2. 27. MPA-Seminar - Safety and reliability in energy technology. Vol. 2: Papers 27-45; 27. MPA-Seminar - Sicherheit und Verfuegbarkeit in der Energietechnik. Bd. 2: Vortraege 27-45

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    The proceedings of the 27th MPA Seminar on 'Safety and Reliability in Energy Technology' were issued in two volumes. The main topics of the second volume are: 1. Material behaviour in the creep regime; 2. Fracture machanics; 3. Reliability analysis and 4. Failure analysis.

  3. Transcriptional regulation of the cydDC operon, encoding a heterodimeric ABC transporter required for assembly of cytochromes c and bd in Escherichia coli K-12: regulation by oxygen and alternative electron acceptors.

    Science.gov (United States)

    Cook, G M; Membrillo-Hernández, J; Poole, R K

    1997-01-01

    The expression of the cydDC operon was investigated by using a chromosomal phi(cydD-lacZ) transcriptional fusion and primer extension analysis. A single transcriptional start site was found for cydD located 68 bp upstream of the translational start site, and Northern blot analysis confirmed that cydDC is transcribed as a polycistronic message independently of the upstream gene trxB. cydDC was highly expressed under aerobic growth conditions and during anaerobic growth with alternative electron acceptors. Aerobic expression was independent of ArcA and Fnr, but induction of cydDC by nitrate and nitrite was dependent on NarL and Fnr. PMID:9335308

  4. Sustainable development - theory and practice of environmental consulting. Proceedings of a seminar of Zentrale Informationsstelle Umweltberatung Bayern. Vol. 11; Nachhaltige Entwicklung - Theorie und Praxis fuer die Umweltberatung. Seminarband der Zentralen Informationsstelle Umweltberatung Bayern. Bd. 11

    Energy Technology Data Exchange (ETDEWEB)

    Koller, U.; Behling, G.; Klemmer, A.; Haury, H.J. [comps.

    1998-12-31

    On 25/26 November, 1997, Zentrale Informationsstelle, Umweltberatung Bayern held its 11th seminar under the title ``Sustainable development - theory and practice of environmental consulting. Subjects related to the Agenda 21 were discussed in lectures and workshops. [Deutsch] Am 25. und 26. November 1997 veranstaltete die Zentrale Informationsstelle, Umweltberatung Bayern ihr elftes Seminar mit dem Thema ``Nachhaltige Entwicklung- Theorie und Praxis fuer die Umweltberatung``. In Fachvortraegen und Workshops wurden Themen zur Agenda 21 behandelt. (ABI)

  5. The BdV screen of memory and Ciutat d'Asunción boulevard at the Baró de Viver neighborhood (Barcelona: (rethinking citizens' participation in urban design

    Directory of Open Access Journals (Sweden)

    Tomeu Vidal

    2012-03-01

    Full Text Available We present a case of citizen participation to design some public spaces in Baró de Viver, a neighbourhood of the city of Barcelona. Our aim is to reflect on the ways to understand citizen participation in political and academic agenda, the role of different actors (citizens, professionals, politicians... and strategies and methods used in participatory urban planning. The experience showed in this paper is located in a scale of urban design very close and well known to the people. We begin with a brief historical overview of the neighborhood where the project arose. Then we give an account of the stages of the participatory process, showing the main milestones, features and methods. Finally we propose some ideas to rethink the conceptual and methodological aspects of the intervention and urban research in environmental psychology and people-environment studies.

  6. Genetic evidence for a high diversity and wide distribution of endemic strains of the pathogenic chytrid fungus Batrachochytrium dendrobatidis in wild Asian amphibians.

    Science.gov (United States)

    Bataille, Arnaud; Fong, Jonathan J; Cha, Moonsuk; Wogan, Guinevere O U; Baek, Hae Jun; Lee, Hang; Min, Mi-Sook; Waldman, Bruce

    2013-08-01

    Population declines and extinctions of amphibians have been attributed to the chytrid fungus Batrachochytrium dendrobatidis (Bd), especially one globally emerging recombinant lineage ('Bd-GPL'). We used PCR assays that target the ribosomal internal transcribed spacer region (ITS) of Bd to determine the prevalence and genetic diversity of Bd in South Korea, where Bd is widely distributed but is not known to cause morbidity or mortality in wild populations. We isolated Korean Bd strains from native amphibians with low infection loads and compared them to known worldwide Bd strains using 19 polymorphic SNP and microsatellite loci. Bd prevalence ranged between 12.5 and 48.0%, in 11 of 17 native Korean species, and 24.7% in the introduced bullfrog Lithobates catesbeianus. Based on ITS sequence variation, 47 of the 50 identified Korean haplotypes formed a group closely associated with a native Brazilian Bd lineage, separated from the Bd-GPL lineage. However, multilocus genotyping of three Korean Bd isolates revealed strong divergence from both Bd-GPL and the native Brazilian Bd lineages. Thus, the ITS region resolves genotypes that diverge from Bd-GPL but otherwise generates ambiguous phylogenies. Our results point to the presence of highly diversified endemic strains of Bd across Asian amphibian species. The rarity of Bd-GPL-associated haplotypes suggests that either this lineage was introduced into Korea only recently or Bd-GPL has been outcompeted by native Bd strains. Our results highlight the need to consider possible complex interactions among native Bd lineages, Bd-GPL and their associated amphibian hosts when assessing the spread and impact of Bd-GPL on worldwide amphibian populations.

  7. Dicty_cDB: CHJ601 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available IMAGE:3153274), complete cds. 36 0.54 3 BD454036 |BD454036.1 NOVEL DNA POLYMERASE III HOLOENZYME DELTA SUBUNIT NUCLEIC... ACID MOLECULES AND PROTEINS. 40 1.1 2 BD454035 |BD454035.1 NOVEL DNA POLYMERASE III HOLOENZYME DELTA SUBUNIT NUCLEIC

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    Lifescience Database Archive (English)

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    Lifescience Database Archive (English)

    Full Text Available 0 9 BD183626 |BD183626.1 Material for diagnosing malaria and immune antigen for suppressing growth of plasmodium.... 76 2e-56 9 BD183625 |BD183625.1 Material for diagnosing malaria and immune antigen for suppressing growth of plasmodium

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    Lifescience Database Archive (English)

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  15. Dicty_cDB: SHK331 [Dicty_cDB

    Lifescience Database Archive (English)

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    Lifescience Database Archive (English)

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    Lifescience Database Archive (English)

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  18. Family Functioning, Social Impairment, and Symptoms Among Adolescents with Bipolar Disorder

    Science.gov (United States)

    Keenan-Miller, Danielle; Peris, Tara; Axelson, David; Kowatch, Robert A.; Miklowitz, David J.

    2012-01-01

    Objective: Impaired social functioning is common among youth with bipolar disorder (BD), emerges in multiple settings, and persists over time. However, little is known about factors associated with poor peer and family functioning in the early-onset form of BD. Using a sample of adolescents with BD I or II, we examined which symptoms of BD,…

  19. Memory in Early Onset Bipolar Disorder and Attention-Deficit/Hyperactivity Disorder: Similarities and Differences

    Science.gov (United States)

    Udal, Anne H.; Oygarden, Bjorg; Egeland, Jens; Malt, Ulrik F.; Groholt, Berit

    2012-01-01

    Differentiating between early-onset bipolar disorder (BD) and attention-deficit/hyperactivity disorder (ADHD) can be difficult. Memory problems are commonly reported in BD, and forgetfulness is among the diagnostic criteria for ADHD. We compared children and adolescents with BD (n = 23), ADHD combined type (ADHD-C; n = 26), BD + ADHD-C (n = 15),…

  20. Dicty_cDB: SSH467 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available =3 Row=J, DNA sequence. 46 0.68 1 BD265981 |BD265981.1 Schizophrenia associated genes, proteins and bialleli...c markers. 40 0.80 2 BD265980 |BD265980.1 Schizophrenia associated genes, proteins and biallelic markers. 40

  1. Dicty_cDB: VFC458 [Dicty_cDB

    Lifescience Database Archive (English)

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    Lifescience Database Archive (English)

    Full Text Available ZMMBMa0497N13, genomic survey sequence. 46 0.23 1 BD251969 |BD251969.1 Artificial matrix attachment region ...for increasing expression of genes introduced in plant cells. 46 0.23 1 BD251970 |BD251970.1 Artificial matr

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    Lifescience Database Archive (English)

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    Lifescience Database Archive (English)

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    Lifescience Database Archive (English)

    Full Text Available equence 183 from Patent WO0168911. 46 1.1 1 BD452308 |BD452308.1 Diagnosis of Diseases Associated with Cell Cycle.... 46 1.1 1 BD460386 |BD460386.1 Diagnosis of Diseases Associated with Cell Cycle. 46 1.1 1 AC149417 |AC

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    Lifescience Database Archive (English)

    Full Text Available 81.1 Sequence 42 from Patent WO0168911. 40 0.083 4 BD460245 |BD460245.1 Diagnosis of Diseases Associated with Cell Cycle.... 40 0.083 4 BD452167 |BD452167.1 Diagnosis of Diseases Associated with Cell Cycle. 40 0.083 4 A

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    Lifescience Database Archive (English)

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    Lifescience Database Archive (English)

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    Lifescience Database Archive (English)

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    Lifescience Database Archive (English)

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    Lifescience Database Archive (English)

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    Lifescience Database Archive (English)

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    Lifescience Database Archive (English)

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    Full Text Available atent WO0168911. 40 0.083 4 BD460245 |BD460245.1 Diagnosis of Diseases Associated with Cell Cycle. 40 0.083 ...4 BD452167 |BD452167.1 Diagnosis of Diseases Associated with Cell Cycle. 40 0.083 4 AC170957 |AC170957.2 Bos

  19. Dicty_cDB: SHF410 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 1781.1 Sequence 42 from Patent WO0168911. 40 0.083 4 BD460245 |BD460245.1 Diagnosis of Diseases Associated with Cell Cycle.... 40 0.083 4 BD452167 |BD452167.1 Diagnosis of Diseases Associated with Cell Cycle. 40 0.083 4

  20. Dicty_cDB: SHA876 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ent WO0168911. 40 0.073 4 BD460245 |BD460245.1 Diagnosis of Diseases Associated with Cell Cycle. 40 0.073 4 ...BD452167 |BD452167.1 Diagnosis of Diseases Associated with Cell Cycle. 40 0.073 4 AJ297856 |AJ297856.1 Lucil

  1. Dicty_cDB: CHH547 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 6 8e-04 1 BD460387 |BD460387.1 Diagnosis of Diseases Associated with Cell Cycle. 32 0.029 5 BD452309 |BD4523...09.1 Diagnosis of Diseases Associated with Cell Cycle. 32 0.029 5 AX348726 |AX348726.1 Sequence 184 from Pat

  2. Dicty_cDB: SHF819 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available WO0200926. 40 0.080 4 BD460245 |BD460245.1 Diagnosis of Diseases Associated with Cell Cycle. 40 0.080 4 BD45...2167 |BD452167.1 Diagnosis of Diseases Associated with Cell Cycle. 40 0.080 4 AJ297856 |AJ297856.1 Lucilia s

  3. Dicty_cDB: SHD283 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available .074 4 BD452167 |BD452167.1 Diagnosis of Diseases Associated with Cell Cycle. 40 0.074 4 BD460245 |BD460245....1 Diagnosis of Diseases Associated with Cell Cycle. 40 0.074 4 AJ297856 |AJ297856.1 Lucilia sericata partial

  4. Dicty_cDB: SHA278 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available O0168911. 40 0.075 4 BD460245 |BD460245.1 Diagnosis of Diseases Associated with Cell Cycle. 40 0.075 4 BD452...167 |BD452167.1 Diagnosis of Diseases Associated with Cell Cycle. 40 0.075 4 AJ29

  5. Dicty_cDB: SHJ640 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 85.1 Sequence 32 from Patent WO0200926. 40 0.086 4 BD460245 |BD460245.1 Diagnosis of Diseases Associated with Cell Cycle.... 40 0.086 4 BD452167 |BD452167.1 Diagnosis of Diseases Associated with Cell Cycle. 40 0.086 4 A

  6. Dicty_cDB: SHA573 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 81 |AX251781.1 Sequence 42 from Patent WO0168911. 40 1.1 3 BD460245 |BD460245.1 Diagnosis of Diseases Associated with Cell Cycle.... 40 1.1 3 BD452167 |BD452167.1 Diagnosis of Diseases Associated with Cell Cycle. 40 1.1

  7. Dicty_cDB: CHK316 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 3 BD460429 |BD460429.1 Diagnosis of Diseases Associated with Cell Cycle. 36 0.11 3 BD452351 |BD452351.1 Diag...nosis of Diseases Associated with Cell Cycle. 36 0.11 3 dna update 2005. 2. 3 Homology vs Protein ***** No h

  8. Dicty_cDB: SHD669 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available Patent WO0168911. 40 0.078 4 BD460245 |BD460245.1 Diagnosis of Diseases Associated with Cell Cycle. 40 0.07...8 4 BD452167 |BD452167.1 Diagnosis of Diseases Associated with Cell Cycle. 40 0.0

  9. Dicty_cDB: SHK515 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 0 4 BD460245 |BD460245.1 Diagnosis of Diseases Associated with Cell Cycle. 40 0.080 4 BD452167 |BD452167.1 D...iagnosis of Diseases Associated with Cell Cycle. 40 0.080 4 AJ297856 |AJ297856.1 Lucilia sericata partial bc

  10. Dicty_cDB: SHF295 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 4 BD460245 |BD460245.1 Diagnosis of Diseases Associated with Cell Cycle. 40 0.077 4 BD452167 |BD452167.1 Dia...gnosis of Diseases Associated with Cell Cycle. 40 0.077 4 AJ297856 |AJ297856.1 Lucilia sericata partial bcd

  11. Dicty_cDB: SSA379 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available quence 6575 from Patent WO02053728. 44 1.4 1 BD082245 |BD082245.1 Bacillus thuringiensis toxins. 34 2.0 2 BD...082244 |BD082244.1 Bacillus thuringiensis toxins. 34 2.0 2 AR107059 |AR107059.1 S

  12. Dicty_cDB: Contig-U16267-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 8208 ) Adenovirus vector, packaging cell line, compositi... 258 e-160 4 ( BD021940 ) Packaging cell systems ...from Patent WO2004099422. 258 e-160 4 ( BD268238 ) Adenovirus vector, packaging cell line, compositi... 258 ...8 e-159 4 ( BD268211 ) Adenovirus vector, packaging cell line, compositi... 258 e-159 4 ( BD021943 ) Packagi

  13. Dicty_cDB: SFC621 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available -binding proteins from staphylococcus aureus. 40 5e-04 2 BD245131 |BD245131.1 Pol... 40 5e-04 2 AJ005646 |AJ005646.1 Staphylococcus aureus sdrD gene. 40 5e-04 2 BD140512 |BD140512.1 Fibrinogen

  14. Dicty_cDB: SLA205 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ynthesizing the nucleic acid. 52 3e-11 2 BD083024 |BD083024.1 Method of detecting difference between gene se...083025 |BD083025.1 Method of detecting difference between gene sequences. 52 5e-1...1652.1 Method for synthesizing the nucleic acid. 52 5e-11 2 BD083026 |BD083026.1 Method of detecting diffe...rence between gene sequences. 52 5e-11 2 BD181438 |BD181438.1 Method for synthesizi

  15. Dicty_cDB: VSC371 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 35 |BD092935.1 Methods and compositions for synthesis of long chain polyunsaturat...ed fatty acids in plants. 658 0.0 1 BD082645 |BD082645.1 Methods and compositions for synthesis of long chai...n polyunsaturated fatty acids. 658 0.0 1 BD082630 |BD082630.1 Methods and compositions for synthesis of long

  16. Dicty_cDB: VSD576 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available delta 5 fatty acid desaturase, complete cds. 1021 0.0 3 BD092935 |BD092935.1 Methods and compositions for sy...nthesis of long chain polyunsaturated fatty acids in plants. 90 4e-47 5 BD082645 |BD082645.1 Methods and composition...82630 |BD082630.1 Methods and compositions for synthesis of long chain poly-unsaturated fatty acids. 90 4e-4

  17. Platelet-rich plasma, plasma rich in growth factors and simvastatin in the regeneration and repair of alveolar bone.

    Science.gov (United States)

    Rivera, César; Monsalve, Francisco; Salas, Juan; Morán, Andrea; Suazo, Iván

    2013-12-01

    Platelet preparations promote bone regeneration by inducing cell migration, proliferation and differentiation in the area of the injury, which are essential processes for regeneration. In addition, several studies have indicated that simvastatin (SIMV), widely used for the treatment of hypercholesterolemia, stimulates osteogenesis. The objective of this study was to evaluate the effects of treatment with either platelet-rich plasma (PRP) or plasma rich in growth factors (PRGF) in combination with SIMV in the regeneration and repair of alveolar bone. The jaws of Sprague Dawley rats (n=18) were subjected to rotary instrument-induced bone damage (BD). Animals were divided into six groups: BD/H2O (n=3), distilled water without the drug and alveolar bone damage; BD/H2O/PRP (n=3), BD and PRP; BD/H2O/PRGF (n=3), BD and PRGF; BD/SIMV (n=3), BD and water with SIMV; BD/SIMV/PRP (n=3), BD, PRP and SIMV; and BD/SIMV/PRGF (n=3), BD, PRGF and SIMV. Conventional histological analysis (hematoxylin and eosin staining) revealed that the BD/SIMV group showed indicators for mature bone tissue, while the BD/SIMV/PRP and BD/SIMV/PRGF groups showed the coexistence of indicators for mature and immature bone tissue, with no statistical differences between the platelet preparations. Simvastatin did not improve the effect of platelet-rich plasma and plasma rich in growth factors. It was not possible to determine which platelet preparation produced superior effects.

  18. Sleep disturbances in pediatric bipolar disorder: A comparison between Bipolar I and Bipolar NOS

    Directory of Open Access Journals (Sweden)

    Argelinda eBaroni

    2012-03-01

    Full Text Available Introduction: The diagnosis of Bipolar Disorder (BD in youths has been controversial, especially for the subtype BD Not Otherwise Specified (BD-NOS. In spite of growing evidence that sleep is a core feature of BD, few studies characterize and compare sleep disturbances in youth with BD type I (BD-I and BD-NOS. Sleep disturbances are frequently reported in clinical descriptions of children and adolescents with BD, however the reporting of the frequency and characteristics of sleep symptoms in youth with BD NOS and BD I during episodes remain poor. This study compares symptom of sleep disturbance as occurring in manic and depressive episodes in BD I and BD NOS youth using KSADS-PL interview data. The study also addresses whether symptoms of sleep disturbance vary in different age groups. Material and Methods: The sample consisted of 70 children and adolescent outpatients at an urban specialty clinic (42M/28F, 10.8±3.6 years old including 24 BP-I and 46 BP-NOS assessed using K-SADS-PL-parent interview. Results: Sleep disturbances including insomnia and decreased need for sleep were reported by 84.3% of the sample. Enuresis was diagnosed in 27% of sample. There were no significant differences in frequency of sleep symptoms between BD-I and BD-NOS. Regardless of BD subtype, current functioning was negatively correlated with decreased need for sleep but not insomnia, and regardless of BD subtype. Conclusion: The majority of youth with BD presents with sleep symptoms during mood episodes. BD NOS presents with the same proportion of sleep symptoms as BD I in our sample.

  19. The use of the Clock Drawing Test in bipolar disorder with or without dementia of Alzheimer’s type

    Directory of Open Access Journals (Sweden)

    Ivan Aprahamian

    2014-12-01

    Full Text Available There is limited data regarding the cognitive profile from screening tests of older adults with bipolar disorder (BD with dementia. Objective To investigate the Clock Drawing Test (CDT among older adults with BD with and without Alzheimer’s disease (AD. Method 209 older adults (79 with BD without dementia and 70 controls; 60 with AD, being 27 with BD were included to evaluate the performance of three CDT scoring scales, beyond the Mini-Mental State Examination (MMSE and verbal fluency (VFT. Results Patients with BD without dementia presented with lower scores in MMSE, VF and one CDT scoring scale than controls. Patients with BD and AD presented with lower scores in VF and CDT scoring scales than patients with only AD. All CDT scales presented similar sensitivity and specificity for BD and non-BD groups. Conclusion Elderly subjects with BD showed greater impairment in CDT in both groups of normal cognition and AD.

  20. Effetto della memantina su modelli animali di disturbi dell'umore

    OpenAIRE

    Demontis, Francesca

    2015-01-01

    AIM: Mood disorders are one of the leading causes of morbidity, disability and premature mortality contributing for about 50% of the non-fatal burden of mental disorders. Bipolar disorder (BD) has a lifetime prevalence of approximately 1.0% for BD-I, 1.1% for BD-II and 2.4% for BD-NOS. Eighty-three percent of BD cases are classified as “seriously severe” and 17.1% as “moderately severe”. Long-term prophylactic treatment of BD aimed at preventing recurrences of the various phases is a le...

  1. Dicty_cDB: SSG614 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ty acid desaturase, complete cds. 113 e-126 13 BD092935 |BD092935.1 Methods and composition...s for synthesis of long chain polyunsaturated fatty acids in plants. 90 1e-54 7 BD082645 |BD082645.1 Methods and compositio...ositions for synthesis of long chain poly-unsaturated fatty acids. 90 1e-54 7 BM161...ns for synthesis of long chain polyunsaturated fatty acids. 90 1e-54 7 BD082630 |BD082630.1 Methods and comp

  2. Dicty_cDB: VFF269 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available BD082645 |BD082645.1 Methods and compositions for synthesis of long chain polyuns...aturated fatty acids. 1304 0.0 2 BD082630 |BD082630.1 Methods and compositions for synthesis of long chain p...04.12.25 Homology vs DNA Score E Sequences producing significant alignments: (bits) Value N BD092935 |BD092935.1 Methods and composit...ions for synthesis of long chain polyunsaturated fatty acids in plants. 1304 0.0 2

  3. Dicty_cDB: CHB310 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available oideum FadB mRNA for delta 5 fatty acid desaturase, complete cds. 68 9e-18 3 BD092935 |BD092935.1 Methods and composition...acids. 70 3e-17 4 BD082630 |BD082630.1 Methods and compositions for synthesis of long chain poly-unsaturated...s for synthesis of long chain polyunsaturated fatty acids in plants. 70 3e-17 4 BD082645 |BD082645.1 Methods and composi...tions for synthesis of long chain polyunsaturated fatty

  4. Dicty_cDB: VSF803 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available for fatty acid desaturase, complete cds. 583 0.0 6 BD092935 |BD092935.1 Methods and compositions for synthe...0 |BD082630.1 Methods and compositions for synthesis of long chain poly-unsaturated fatty acids. 1019 0.0 2 ...sis of long chain polyunsaturated fatty acids in plants. 1019 0.0 2 BD082645 |BD082645.1 Methods and compo...sitions for synthesis of long chain polyunsaturated fatty acids. 1019 0.0 2 BD08263

  5. Dicty_cDB: AFK718 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available cids in plants. 70 9e-17 4 BD082645 |BD082645.1 Methods and compositions for synthesis of long chain polyuns...aturated fatty acids. 70 9e-17 4 BD082630 |BD082630.1 Methods and compositions for synthesis of long chain p...tyostelium discoideum FadB mRNA for delta 5 fatty acid desaturase, complete cds. 68 2e-17 3 BD092935 |BD092935.1 Methods and composit...ions for synthesis of long chain polyunsaturated fatty a

  6. Heterogeneous occupancy and density estimates of the pathogenic fungus Batrachochytrium dendrobatidis in waters of North America.

    Directory of Open Access Journals (Sweden)

    Tara Chestnut

    Full Text Available Biodiversity losses are occurring worldwide due to a combination of stressors. For example, by one estimate, 40% of amphibian species are vulnerable to extinction, and disease is one threat to amphibian populations. The emerging infectious disease chytridiomycosis, caused by the aquatic fungus Batrachochytrium dendrobatidis (Bd, is a contributor to amphibian declines worldwide. Bd research has focused on the dynamics of the pathogen in its amphibian hosts, with little emphasis on investigating the dynamics of free-living Bd. Therefore, we investigated patterns of Bd occupancy and density in amphibian habitats using occupancy models, powerful tools for estimating site occupancy and detection probability. Occupancy models have been used to investigate diseases where the focus was on pathogen occurrence in the host. We applied occupancy models to investigate free-living Bd in North American surface waters to determine Bd seasonality, relationships between Bd site occupancy and habitat attributes, and probability of detection from water samples as a function of the number of samples, sample volume, and water quality. We also report on the temporal patterns of Bd density from a 4-year case study of a Bd-positive wetland. We provide evidence that Bd occurs in the environment year-round. Bd exhibited temporal and spatial heterogeneity in density, but did not exhibit seasonality in occupancy. Bd was detected in all months, typically at less than 100 zoospores L(-1. The highest density observed was ∼3 million zoospores L(-1. We detected Bd in 47% of sites sampled, but estimated that Bd occupied 61% of sites, highlighting the importance of accounting for imperfect detection. When Bd was present, there was a 95% chance of detecting it with four samples of 600 ml of water or five samples of 60 mL. Our findings provide important baseline information to advance the study of Bd disease ecology, and advance our understanding of amphibian exposure to free

  7. Heterogeneous occupancy and density estimates of the pathogenic fungus Batrachochytrium dendrobatidis in waters of North America

    Science.gov (United States)

    Chestnut, Tara E.; Anderson, Chauncey; Popa, Radu; Blaustein, Andrew R.; Voytek, Mary; Olson, Deanna H.; Kirshtein, Julie

    2014-01-01

    Biodiversity losses are occurring worldwide due to a combination of stressors. For example, by one estimate, 40% of amphibian species are vulnerable to extinction, and disease is one threat to amphibian populations. The emerging infectious disease chytridiomycosis, caused by the aquatic fungus Batrachochytrium dendrobatidis (Bd), is a contributor to amphibian declines worldwide. Bd research has focused on the dynamics of the pathogen in its amphibian hosts, with little emphasis on investigating the dynamics of free-living Bd. Therefore, we investigated patterns of Bd occupancy and density in amphibian habitats using occupancy models, powerful tools for estimating site occupancy and detection probability. Occupancy models have been used to investigate diseases where the focus was on pathogen occurrence in the host. We applied occupancy models to investigate free-living Bd in North American surface waters to determine Bd seasonality, relationships between Bd site occupancy and habitat attributes, and probability of detection from water samples as a function of the number of samples, sample volume, and water quality. We also report on the temporal patterns of Bd density from a 4-year case study of a Bd-positive wetland. We provide evidence that Bd occurs in the environment year-round. Bd exhibited temporal and spatial heterogeneity in density, but did not exhibit seasonality in occupancy. Bd was detected in all months, typically at less than 100 zoospores L−1. The highest density observed was ∼3 million zoospores L−1. We detected Bd in 47% of sites sampled, but estimated that Bd occupied 61% of sites, highlighting the importance of accounting for imperfect detection. When Bd was present, there was a 95% chance of detecting it with four samples of 600 ml of water or five samples of 60 mL. Our findings provide important baseline information to advance the study of Bd disease ecology, and advance our understanding of amphibian exposure to free-living Bd in aquatic

  8. Biodiesel versus diesel exposure: Enhanced pulmonary inflammation, oxidative stress, and differential morphological changes in the mouse lung

    Energy Technology Data Exchange (ETDEWEB)

    Yanamala, Naveena, E-mail: wqu1@cdc.gov [Pathology and Physiology Research Branch/NIOSH/CDC, Morgantown, WV 26505 (United States); Hatfield, Meghan K., E-mail: wla4@cdc.gov [Pathology and Physiology Research Branch/NIOSH/CDC, Morgantown, WV 26505 (United States); Farcas, Mariana T., E-mail: woe7@cdc.gov [Pathology and Physiology Research Branch/NIOSH/CDC, Morgantown, WV 26505 (United States); Schwegler-Berry, Diane [Pathology and Physiology Research Branch/NIOSH/CDC, Morgantown, WV 26505 (United States); Hummer, Jon A., E-mail: qzh3@cdc.gov [Office of Mine Safety and Health Research/NIOSH/CDC, Pittsburgh, PA 15236 (United States); Shurin, Michael R., E-mail: shurinmr@upmc.edu [Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA (United States); Birch, M. Eileen, E-mail: mib2@cdc.gov [NIOSH/CDC, 4676 Columbia Parkway, Cincinnati, OH 45226 (United States); Gutkin, Dmitriy W., E-mail: dwgutkin@hotmail.com [Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA (United States); Kisin, Elena, E-mail: edk8@cdc.gov [Pathology and Physiology Research Branch/NIOSH/CDC, Morgantown, WV 26505 (United States); Kagan, Valerian E., E-mail: kagan@pitt.edu [Department of Environmental and Occupational Health, University of Pittsburgh, PA (United States); Bugarski, Aleksandar D., E-mail: zjl1@cdc.gov [Office of Mine Safety and Health Research/NIOSH/CDC, Pittsburgh, PA 15236 (United States); Shvedova, Anna A., E-mail: ats1@cdc.gov [Pathology and Physiology Research Branch/NIOSH/CDC, Morgantown, WV 26505 (United States); Department Physiology and Pharmacology, WVU, Morgantown, WV 26505 (United States)

    2013-10-15

    The use of biodiesel (BD) or its blends with petroleum diesel (D) is considered to be a viable approach to reduce occupational and environmental exposures to particulate matter (PM). Due to its lower particulate mass emissions compared to D, use of BD is thought to alleviate adverse health effects. Considering BD fuel is mainly composed of unsaturated fatty acids, we hypothesize that BD exhaust particles could induce pronounced adverse outcomes, due to their ability to readily oxidize. The main objective of this study was to compare the effects of particles generated by engine fueled with neat BD and neat petroleum-based D. Biomarkers of tissue damage and inflammation were significantly elevated in lungs of mice exposed to BD particulates. Additionally, BD particulates caused a significant accumulation of oxidatively modified proteins and an increase in 4-hydroxynonenal. The up-regulation of inflammatory cytokines/chemokines/growth factors was higher in lungs upon BD particulate exposure. Histological evaluation of lung sections indicated presence of lymphocytic infiltrate and impaired clearance with prolonged retention of BD particulate in pigment laden macrophages. Taken together, these results clearly indicate that BD exhaust particles could exert more toxic effects compared to D. - Highlights: • Exposure of mice to BDPM caused higher pulmonary toxicity compared to DPM. • Oxidative stress and inflammation were higher in BD vs to D exposed mice. • Inflammatory lymphocyte infiltrates were seen only in lungs of mice exposed to BD. • Ineffective clearance, prolonged PM retention was present only after BD exposure.

  9. Antimicrobial activity of human β-defensins against lactic acid bacteria.

    Science.gov (United States)

    Wang, Xiao-Fang; Tian, Fei; Cao, Rui-Ming; Li, Jing; Wu, Sheng-Mei; Guo, Xiao-Kui; Chen, Tong-Xin

    2015-01-01

    In this study, we evaluated the antimicrobial activity of human β-defensin-1 (hBD-1), human β-defensin-2 (hBD-2) and human β-defensin-3 (hBD-3) against three internationally common probiotic strains of lactic acid bacterium. Our results indicated that hBD-1, hBD-2 and hBD-3 at the range of 0.08-10 μg/mL do not have obvious antimicrobial activity against these strains. Viability of Bifidobacterium longum JDM301 (B. longum JDM301), Bifidobacterium lactis HN019 (B. lactis HN019) and Lactobacillus rhamnosus GG (LGG) were still very high even at concentration of 10 μg hBD/mL. Then, we explored the mechanism of resistance by using carbonyl cyanide 3-chlorophenylhydrazone (CCCP) to inhibit efflux pumps. In the presence of CCCP, hBD-1, hBD-2 and hBD-3 exhibited enhanced antibacterial effect against B. longum JDM301 and B. lactis HN019, but not against LGG. Efflux pumps in B. longum JDM301 and B. lactis HN019 may partly contribute to their resistance to hBD-1, hBD-2, and hBD-3.

  10. Dicty_cDB: VFG409 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available stelium discoideum chromosome 2 map complement(581327-427576) strain AX4, complete sequence. 888 0.0 1 BD244275 |BD244275.1 Determina...tion method of nucleotide sequence using arbitrary prime

  11. Dicty_cDB: SLK306 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available bacter polypeptides in the helicobacter genome. 40 0.33 ...* SEQUENCING IN PROGRESS ***, 1 ordered piece. 36 0.23 3 BD092471 |BD092471.1 Identification of polynucleotides encoding novel helico

  12. GenBank blastn search result: AK288629 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK288629 J090054P17 BD356794.1 BD356794 METHOD FOR OBTAINING NUCLEIC ACIDS FROM AN ...ENVIRONMENT SAMPLE, RESULTING NUCLEIC ACIDS AND USE IN SYNTHESIS OF NOVEL COMPOUNDS. PAT 5e-46 1 1 ...

  13. Dicty_cDB: SHE502 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available on, kit and method for treating respiratory tract disorder related to bronchoconstriction, pneumonia, allerg... 71 unordered pieces. 40 0.009 2 BD323302 |BD323302.1 Low-adenosine antisense oligonucleotide, its compositi

  14. Dicty_cDB: FC-IC0700 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ating respiratory tract disorder related to bronchoconstriction, pneumonia, allergy...09 5 BD322951 |BD322951.1 Low-adenosine antisense oligonucleotide, its composition, kit and method for tre

  15. Dicty_cDB: CHC316 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available malaria and immune antigen for suppressing growth of plasmodium. 58 9e-19 6 BD183...625 |BD183625.1 Material for diagnosing malaria and immune antigen for suppressing growth of plasmodium. 58

  16. Dicty_cDB: SFH339 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available mune antigen for suppressing growth of plasmodium. 76 1e-62 10 BD183625 |BD183625.1 Material for diagnosing ...malaria and immune antigen for suppressing growth of plasmodium. 76 1e-62 10 AB02

  17. Dicty_cDB: SFC750 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available for diagnosing malaria and immune antigen for suppressing growth of plasmodium. 76 2e-45 7 BD183625 |BD1836...25.1 Material for diagnosing malaria and immune antigen for suppressing growth of plasmodium

  18. Dicty_cDB: SFE744 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available and immune antigen for suppressing growth of plasmodium. 76 1e-62 10 BD183625 |BD183625.1 Material for diag...nosing malaria and immune antigen for suppressing growth of plasmodium. 76 1e-62

  19. Dicty_cDB: CFH624 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available l for diagnosing malaria and immune antigen for suppressing growth of plasmodium.... 58 9e-19 6 BD183626 |BD183626.1 Material for diagnosing malaria and immune antigen for suppressing growth of plasmodium

  20. Dicty_cDB: AFK881 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available gnosing malaria and immune antigen for suppressing growth of plasmodium. 76 4e-57... 10 BD183626 |BD183626.1 Material for diagnosing malaria and immune antigen for suppressing growth of plasmodium

  1. Dicty_cDB: SFB722 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available aria and immune antigen for suppressing growth of plasmodium. 76 1e-62 10 BD183625 |BD183625.1 Material for ...diagnosing malaria and immune antigen for suppressing growth of plasmodium. 76 1e

  2. Dicty_cDB: AFJ620 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available rial for diagnosing malaria and immune antigen for suppressing growth of plasmodium.... 76 2e-56 10 BD183625 |BD183625.1 Material for diagnosing malaria and immune antigen for suppressing growth of plasmodium

  3. Dicty_cDB: CFK240 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available for diagnosing malaria and immune antigen for suppressing growth of plasmodium. 5...8 3e-16 5 BD183625 |BD183625.1 Material for diagnosing malaria and immune antigen for suppressing growth of plasmodium

  4. Dicty_cDB: SFC877 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available aterial for diagnosing malaria and immune antigen for suppressing growth of plasmodium. 62 2e-17 3 BD183625 ...|BD183625.1 Material for diagnosing malaria and immune antigen for suppressing growth of plasmodium

  5. Dicty_cDB: AFF763 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available diagnosing malaria and immune antigen for suppressing growth of plasmodium. 58 8e...-19 6 BD183625 |BD183625.1 Material for diagnosing malaria and immune antigen for suppressing growth of plasmodium

  6. Dicty_cDB: SFC432 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ia and immune antigen for suppressing growth of plasmodium. 76 5e-50 9 BD183625 |...BD183625.1 Material for diagnosing malaria and immune antigen for suppressing growth of plasmodium. 76 5e-50

  7. Dicty_cDB: AFK138 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available diagnosing malaria and immune antigen for suppressing growth of plasmodium. 76 3...e-58 9 BD183625 |BD183625.1 Material for diagnosing malaria and immune antigen for suppressing growth of plasmodium

  8. Dicty_cDB: AFI164 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available sing malaria and immune antigen for suppressing growth of plasmodium. 62 1e-29 6 BD183625 |BD183625.1 Materi...al for diagnosing malaria and immune antigen for suppressing growth of plasmodium

  9. Dicty_cDB: CFJ407 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available laria and immune antigen for suppressing growth of plasmodium. 58 3e-24 7 BD183625 |BD183625.1 Material for ...diagnosing malaria and immune antigen for suppressing growth of plasmodium. 58 3e

  10. Dicty_cDB: AFB731 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available alaria and immune antigen for suppressing growth of plasmodium. 58 4e-19 6 BD1836...26 |BD183626.1 Material for diagnosing malaria and immune antigen for suppressing growth of plasmodium. 58 4

  11. Dicty_cDB: AFI668 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available igen for suppressing growth of plasmodium. 76 1e-60 10 BD183625 |BD183625.1 Material for diagnosing malaria ...and immune antigen for suppressing growth of plasmodium. 76 1e-60 10 AB026051 |AB

  12. Dicty_cDB: SFJ731 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available g malaria and immune antigen for suppressing growth of plasmodium. 58 7e-19 6 BD1...83625 |BD183625.1 Material for diagnosing malaria and immune antigen for suppressing growth of plasmodium. 5

  13. Dicty_cDB: CHD848 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available osing malaria and immune antigen for suppressing growth of plasmodium. 58 4e-16 5 BD183625 |BD183625.1 Mater...ial for diagnosing malaria and immune antigen for suppressing growth of plasmodium

  14. Dicty_cDB: CFG454 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available m producing amylase constructed by recombinant DNA technique and utilization thereof in fermentation method.... 56 7e-04 1 BD000146 |BD000146.1 Microorganism producing amylase constructed by recombinant DNA technique an

  15. Dicty_cDB: SFI492 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available tiated in human neuroblastoma with good prognosis, in comparion between human neuroblastoma with good prog...nosis and human neuroblastoma with bad prognosis. 40 7.1 1 BD021755 |BD021755.1 Nov

  16. Dicty_cDB: SFC252 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available BD083792 |BD083792.1 Nucleic acid sequence characterized in that expression is potentiated in human neuroblastoma with good prognosi...s, in comparion between human neuroblastoma with good prognosis and human neuroblastoma with bad prognosis

  17. Dicty_cDB: VFC590 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available for gene expression in pichia ciferri and transformation method using the same. ...ciparum glyceraldehyde-3-phosphate dehydrogenase mRNA, complete cds. 78 3e-49 7 BD218177 |BD218177.1 Plasmid

  18. Dicty_cDB: Contig-U06538-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 38 0.090 2 ( DJ207695 ) Method for identification of useful proteins deri... 38 0.090 2 ( BD343987 ) Method of monitoring... gene expression. 38 0.090 2 ( BD341931 ) Method of monitoring gene

  19. Drug: D10266 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available ormin hydrochloride mixt; Glucovance (TN) Glibenclamide, Glyburide [DR:D00336], Metformin hydrochloride [DR:...GLUCOSE LOWERING DRUGS, EXCL. INSULINS A10BD Combinations of oral blood glucose lowering drugs A10BD02 Metformin

  20. Glutamatergic and HPA-axis pathway genes in bipolar disorder comorbid with alcohol- and substance use disorders.

    Science.gov (United States)

    Dalvie, Shareefa; Fabbri, Chiara; Ramesar, Raj; Serretti, Alessandro; Stein, Dan J

    2016-02-01

    Glutamatergic neurotransmission has been shown to be dysregulated in bipolar disorder (BD), alcohol use disorder (AUD) and substance use disorder (SUD). Similarly, disruption in the hypothalamic-pituitary-adrenal (HPA)-axis has also been observed in these conditions. BD is often comorbid with AUD and SUD. The effects of the glutamatergic and HPA systems have not been extensively examined in individuals with BD-AUD and BD-SUD comorbidity. The aim of this investigation was to determine whether variants in the glutamatergic pathway and HPA-axis are associated with BD-AUD and BD-SUD comorbidity. The research cohort consisted of 498 individuals with BD type I from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). A subset of the cohort had comorbid current AUD and current SUD. A total of 1935 SNPs from both the glutamatergic and HPA pathways were selected from the STEP-BD genome-wide dataset. To identify population stratification, IBS clustering was performed using the program Plink 1.07. Single SNP association and gene-based association testing were conducted using logistic regression. A pathway analysis of glutamatergic and HPA genes was performed, after imputation using IMPUTE2. No single SNP was associated with BD-AUD or BD-SUD comorbidity after correction for multiple testing. However, from the gene-based analysis, the gene PRKCI was significantly associated with BD-AUD. The pathway analysis provided overall negative findings, although several genes including GRIN2B showed high percentage of associated SNPs for BD-AUD. Even though the glutamatergic and HPA pathways may not be involved in BD-AUD and BD-SUD comorbidity, PRKCI deserves further investigation in BD-AUD.