WorldWideScience

Sample records for basket-prove prospective validation

  1. Drug-eluting or bare-metal stents for large coronary vessel stenting? The BASKET-PROVE (PROspective Validation Examination) trial: Study protocol and design

    DEFF Research Database (Denmark)

    Pfisterer, M.; Bertel, O.; Bonetti, P.O.;

    2008-01-01

    Background Based on a subgroup analysis of 18-month BAsel Stent Kosten Effektivitats Trial (BASKET) outcome data, we hypothesized that very late (>12 months) stent thrombosis occurs predominantly after drug-eluting stent implantation in large native coronary vessel stenting. Methods To prove...... stent use in patients with large native vessel stenting. The 2-year death/myocardial infarction-as well as target vessel revascularization-and bleeding rates in these patients with a first-versus second-generation drug-eluting stent should demonstrate the benefit or harm of these stents compared...

  2. The Multinomial Model of Prospective Memory: Validity of Ongoing-Task Parameters

    OpenAIRE

    Horn, Sebastian S.; Bayen, Ute J.; Smith, Rebekah E.; Boywitt, C. Dennis

    2011-01-01

    The objective of this research was to provide additional experimental validation of the multinomial processing tree (MPT) model of event-based prospective memory (Smith & Bayen, 2004). In particular, the parameters that measure trial type detection in the ongoing task were examined. In three experiments with different response instructions, event-based prospective memory tasks were embedded in ongoing color-matching tasks. The results support the validity of the MPT model, that is, manipulati...

  3. Validation of the automatic image analyser to assess retinal vessel calibre (ALTAIR): a prospective study protocol

    OpenAIRE

    Garcia-Ortiz, Luis; Gómez-Marcos, Manuel A.; Recio-Rodríguez, Jose I; Maderuelo-Fernández, Jose A; Chamoso-Santos, Pablo; Rodríguez-González, Sara; de Paz-Santana, Juan F; Merchan-Cifuentes, Miguel A; Corchado-Rodríguez, Juan M

    2014-01-01

    Introduction The fundus examination is a non-invasive evaluation of the microcirculation of the retina. The aim of the present study is to develop and validate (reliability and validity) the ALTAIR software platform (Automatic image analyser to assess retinal vessel calibre) in order to analyse its utility in different clinical environments. Methods and analysis A cross-sectional study in the first phase and a prospective observational study in the second with 4 years of follow-up. The study ...

  4. A prospective validation of the HEART score for chest pain patients at the emergency department

    NARCIS (Netherlands)

    Backus, B. E.; Six, A. J.; Kelder, J. C.; Bosschaert, M. A. R.; Mast, E. G.; Mosterd, A.; Veldkamp, R. F.; Wardeh, A. J.; Tio, R.; Braam, R.; Monnink, S. H. J.; van Tooren, R.; Mast, T. P.; van den Akker, F.; Cramer, M. J. M.; Poldervaart, J. M.; Hoes, A. W.; Doevendans, P. A.

    2013-01-01

    Background: The focus of the diagnostic process in chest pain patients at the emergency department is to identify both low and high risk patients for an acute coronary syndrome (ACS). The HEART score was designed to facilitate this process. This study is a prospective validation of the HEART score.

  5. Self-report measures of prospective memory are reliable but not valid.

    Science.gov (United States)

    Uttl, Bob; Kibreab, Mekale

    2011-03-01

    Are self-report measures of prospective memory (ProM) reliable and valid? To examine this question, 240 undergraduate student volunteers completed several widely used self-report measures of ProM including the Prospective Memory Questionnaire (PMQ), the Prospective and Retrospective Memory Questionnaire (PRMQ), the Comprehensive Assessment of Prospective Memory (CAPM) questionnaire, self-reports of retrospective memory (RetM), objective measures of ProM and RetM, and measures of involvement in activities and events, memory strategies and aids use, personality and verbal intelligence. The results showed that both convergent and divergent validity of ProM self-reports are poor, even though we assessed ProM using a newly developed, reliable continuous measure. Further analyses showed that a substantial proportion of variability in ProM self-report scores was due to verbal intelligence, personality (conscientiousness, neuroticism), activities and event involvement (busyness), and use of memory strategies and aids. ProM self-reports have adequate reliability, but poor validity and should not be interpreted as reflecting ProM ability.

  6. Prospective independent validation of IMPACT modeling as a prognostic tool in severe traumatic brain injury.

    Science.gov (United States)

    Panczykowski, David M; Puccio, Ava M; Scruggs, Bobby J; Bauer, Joshua S; Hricik, Allison J; Beers, Sue R; Okonkwo, David O

    2012-01-01

    Clinical trials in traumatic brain injury (TBI) have been fraught with failure due in part to heterogeneity in pathology and insensitive outcome measurements. The International Mission for Prognosis and Analysis of Clinical Trials in TBI (IMPACT) prognostic model has been purposed as a means of risk adjustment and outcome prediction for use in trial design and analysis. The purpose of this study was to evaluate the performance of the IMPACT model in predicting 6-month functional outcome and mortality using prospectively collected data at a large, Level 1 neurotrauma center. This population-based cohort study included all TBI patients ≥14 years of age admitted with a Glasgow Coma Scale (GCS) score of ≤8 (severe TBI) to the University of Pittsburgh Medical Center between July 1994 and May 2009. Clinical data were prospectively collected and linked to 6-month functional outcome (Glasgow Outcome Scale [GOS]) and mortality. The discriminatory power and calibration of the three iterations of the IMPACT model (core, extended, and lab) were assessed using multiple regression analyses and indicated by the area under the receiver operating characteristic curve (AUC). A sample of 587 patients was available for analysis; the mean age was 37.8±17 years. The median 6-month GOS was 3 (IQR 3); 6-month mortality was 41%. The prognostic models were composed of age, motor score, and pupillary reactivity (core model), Marshall grade on head CT and secondary insults (extended), and laboratory values (lab); all of these displayed good prediction ability for unfavorable outcome and mortality (unfavorable outcome AUC=0.76, 0.79, 0.76; mortality AUC=0.78, 0.83, 0.83, respectively). All model iterations displayed adequate calibration for predicting unfavorable outcome and mortality. Prospective, independent validation supports the IMPACT prognostic model's prediction of patient 6-month functional status and mortality after severe TBI. The IMPACT prognostic model is an effective

  7. Validation of a model for optimal birth weight: a prospective study using serial ultrasounds

    Directory of Open Access Journals (Sweden)

    Pereira Gavin

    2012-06-01

    Full Text Available Abstract Background The aim of this study was to validate a model for optimal birth weight derived from neonatal records, and to test the assumption that preterm births may be considered optimally grown if they are not exposed to common factors that perturb fetal growth. Methods Weights of fetuses were estimated from serial biometric ultrasound scans (N = 2,848 and combined with neonatal weights for a prospective pregnancy cohort (N = 691. Non-Caucasians, fetuses subsequently born preterm and those with diagnosed or suspected determinants of aberrant growth were excluded leaving fetuses assumed to have experienced normal growth. A generalised linear longitudinal growth model for optimal weight was derived, including terms for gestational duration, infant sex, maternal height and birth order. This model was compared to a published model derived solely from birth weights. Results Prior to 30 weeks gestation, the published model yielded systematically lower weights than the model derived from both fetal weight and neonatal weight. From 30 weeks gestation the two models were indistinguishable. Conclusion The model for optimal birth weight was valid for births that have attained at least 30 weeks gestation. The model derived from both fetal and neonatal weights is recommended prior to this gestation.

  8. Prospective Validation of Modified NEXUS Cervical Spine Injury Criteria in Low-risk Elderly Fall Patients

    Directory of Open Access Journals (Sweden)

    John Tran

    2016-05-01

    Full Text Available Introduction: The National Emergency X-radiography Utilization Study (NEXUS criteria are used extensively in emergency departments to rule out C-spine injuries (CSI in the general population. Although the NEXUS validation set included 2,943 elderly patients, multiple case reports and the Canadian C-Spine Rules question the validity of applying NEXUS to geriatric populations. The objective of this study was to validate a modified NEXUS criteria in a low-risk elderly fall population with two changes: a modified definition for distracting injury and the definition of normal mentation. Methods: This is a prospective, observational cohort study of geriatric fall patients who presented to a Level I trauma center and were not triaged to the trauma bay. Providers enrolled non-intoxicated patients at baseline mental status with no lateralizing neurologic deficits. They recorded midline neck tenderness, signs of trauma, and presence of other distracting injury. Results: We enrolled 800 patients. One patient fall event was excluded due to duplicate enrollment, and four were lost to follow up, leaving 795 for analysis. Average age was 83.6 (range 65-101. The numbers in parenthesis after the negative predictive value represent confidence interval. There were 11 (1.4% cervical spine injuries. One hundred seventeen patients had midline tenderness and seven of these had CSI; 366 patients had signs of trauma to the face/neck, and 10 of these patients had CSI. Using signs of trauma to the head/neck as the only distracting injury and baseline mental status as normal alertness, the modified NEXUS criteria was 100% sensitive (CI [67.9-100] with a negative predictive value of 100 (98.7-100. Conclusion: Our study suggests that a modified NEXUS criteria can be safely applied to low-risk elderly falls.

  9. Validation of the Cambridge Prospective Memory Test (Hong Kong Chinese version) for people with stroke.

    Science.gov (United States)

    Man, David W K; Chan, M K L; Yip, C C K

    2015-01-01

    This study aimed to develop and evaluate a Hong Kong Chinese version of the Cambridge Prospective Memory Test (CAMPROMPT-HKCV). Thirty-three subjects at least one year post-stroke participated in the study. They were simultaneously rated on version A of the CAMPROMPT-HKCV by two testers to establish its internal consistency and inter-rater reliability. Raters used the parallel versions of the test (A and B), in rating 10 patients within 2 weeks to establish the parallel form reliability. Another 10 were also assessed on the same day using both version A of the CAMPROMPT-HKCV and the Rivermead Behavioural Memory Test-Chinese version (RBMT-CV) to establish concurrent validity. A new group of 40 stroke patients and 44 healthy controls was recruited to establish its sensitivity and specificity. Results indicated that test-retest reliability on time-based, event-based and total scores, and inter-rater reliability for versions A and B of the test were high. Cronbach's alpha of the event-based score was higher than that of the time-based score. The reliability and concurrent validity of the parallel forms were established. There was a significant difference in performance on CAMPROMPT-HKCV (version A) between the stroke group and the healthy control group. ROC analysis showed that the ability of the cut-off CAMPROMPT-HKCV (total score) to differentiate PM problems was 20.5 (out of 36) with sensitivity at 95.5% and specificity at 55.9%. Further study in developing stratified norms across different age groups in Chinese-speaking stroke patients is recommended.

  10. Validation of the Ottawa Ankle Rules in Iran: A prospective survey

    Directory of Open Access Journals (Sweden)

    Ghofrani Hossein

    2006-02-01

    Full Text Available Abstract Background Acute ankle injuries are one of the most common reasons for presenting to emergency departments, but only a small percentage of patients – approximately 15% – have clinically significant fractures. However, these patients are almost always referred for radiography. The Ottawa Ankle Rules (OARs have been designed to reduce the number of unnecessary radiographs ordered for these patients. The objective of this study was to validate the OARs in the Iranian population. Methods This prospective survey was done among 200 patients with acute ankle injury from January 2004 to April 2004 in the Akhtar Orthopedics Hospital Emergency Department. Main outcome measures of this survey were: sensitivity, specificity, positive predictive value, negative predictive value, and likelihood ratios (positive and negative of the OARs. Results Sensitivity of the OARs for detecting 37 ankle fractures (23 in the malleolar zone and 14 in the midfoot zone was 100% for each of the two zones, and 100% for both zones. Specificity of the OARs for detecting fractures was 40.50% for both zones, 40.50% for the malleolar zone, and 56.00% for the midfoot zone. Implementation of the OARs had the potential for reducing radiographs by 33%. Conclusion OARs are very accurate and highly sensitive tools for detecting ankle fractures. Implementation of these rules would lead to significant reduction in the number of radiographs, costs, radiation exposure and waiting times in emergency departments.

  11. The predictive validity of prospect theory versus expected utility in health utility measurement.

    Science.gov (United States)

    Abellan-Perpiñan, Jose Maria; Bleichrodt, Han; Pinto-Prades, Jose Luis

    2009-12-01

    Most health care evaluations today still assume expected utility even though the descriptive deficiencies of expected utility are well known. Prospect theory is the dominant descriptive alternative for expected utility. This paper tests whether prospect theory leads to better health evaluations than expected utility. The approach is purely descriptive: we explore how simple measurements together with prospect theory and expected utility predict choices and rankings between more complex stimuli. For decisions involving risk prospect theory is significantly more consistent with rankings and choices than expected utility. This conclusion no longer holds when we use prospect theory utilities and expected utilities to predict intertemporal decisions. The latter finding cautions against the common assumption in health economics that health state utilities are transferable across decision contexts. Our results suggest that the standard gamble and algorithms based on, should not be used to value health. PMID:19833400

  12. The predictive validity of prospect theory versus expected utility in health utility measurement.

    Science.gov (United States)

    Abellan-Perpiñan, Jose Maria; Bleichrodt, Han; Pinto-Prades, Jose Luis

    2009-12-01

    Most health care evaluations today still assume expected utility even though the descriptive deficiencies of expected utility are well known. Prospect theory is the dominant descriptive alternative for expected utility. This paper tests whether prospect theory leads to better health evaluations than expected utility. The approach is purely descriptive: we explore how simple measurements together with prospect theory and expected utility predict choices and rankings between more complex stimuli. For decisions involving risk prospect theory is significantly more consistent with rankings and choices than expected utility. This conclusion no longer holds when we use prospect theory utilities and expected utilities to predict intertemporal decisions. The latter finding cautions against the common assumption in health economics that health state utilities are transferable across decision contexts. Our results suggest that the standard gamble and algorithms based on, should not be used to value health.

  13. Prospective Study of One Million Deaths in India: Rationale, Design, and Validation Results.

    Directory of Open Access Journals (Sweden)

    2005-12-01

    Full Text Available BACKGROUND: Over 75% of the annual estimated 9.5 million deaths in India occur in the home, and the large majority of these do not have a certified cause. India and other developing countries urgently need reliable quantification of the causes of death. They also need better epidemiological evidence about the relevance of physical (such as blood pressure and obesity, behavioral (such as smoking, alcohol, HIV-1 risk taking, and immunization history, and biological (such as blood lipids and gene polymorphisms measurements to the development of disease in individuals or disease rates in populations. We report here on the rationale, design, and implementation of the world's largest prospective study of the causes and correlates of mortality. METHODS AND FINDINGS: We will monitor nearly 14 million people in 2.4 million nationally representative Indian households (6.3 million people in 1.1 million households in the 1998-2003 sample frame and 7.6 million people in 1.3 million households in the 2004-2014 sample frame for vital status and, if dead, the causes of death through a well-validated verbal autopsy (VA instrument. About 300,000 deaths from 1998-2003 and some 700,000 deaths from 2004-2014 are expected; of these about 850,000 will be coded by two physicians to provide causes of death by gender, age, socioeconomic status, and geographical region. Pilot studies will evaluate the addition of physical and biological measurements, specifically dried blood spots. Preliminary results from over 35,000 deaths suggest that VA can ascertain the leading causes of death, reduce the misclassification of causes, and derive the probable underlying cause of death when it has not been reported. VA yields broad classification of the underlying causes in about 90% of deaths before age 70. In old age, however, the proportion of classifiable deaths is lower. By tracking underlying demographic denominators, the study permits quantification of absolute mortality rates

  14. Prospective study of one million deaths in India: rationale, design, and validation results.

    Directory of Open Access Journals (Sweden)

    Prabhat Jha

    2006-02-01

    Full Text Available BACKGROUND: Over 75% of the annual estimated 9.5 million deaths in India occur in the home, and the large majority of these do not have a certified cause. India and other developing countries urgently need reliable quantification of the causes of death. They also need better epidemiological evidence about the relevance of physical (such as blood pressure and obesity, behavioral (such as smoking, alcohol, HIV-1 risk taking, and immunization history, and biological (such as blood lipids and gene polymorphisms measurements to the development of disease in individuals or disease rates in populations. We report here on the rationale, design, and implementation of the world's largest prospective study of the causes and correlates of mortality. METHODS AND FINDINGS: We will monitor nearly 14 million people in 2.4 million nationally representative Indian households (6.3 million people in 1.1 million households in the 1998-2003 sample frame and 7.6 million people in 1.3 million households in the 2004-2014 sample frame for vital status and, if dead, the causes of death through a well-validated verbal autopsy (VA instrument. About 300,000 deaths from 1998-2003 and some 700,000 deaths from 2004-2014 are expected; of these about 850,000 will be coded by two physicians to provide causes of death by gender, age, socioeconomic status, and geographical region. Pilot studies will evaluate the addition of physical and biological measurements, specifically dried blood spots. Preliminary results from over 35,000 deaths suggest that VA can ascertain the leading causes of death, reduce the misclassification of causes, and derive the probable underlying cause of death when it has not been reported. VA yields broad classification of the underlying causes in about 90% of deaths before age 70. In old age, however, the proportion of classifiable deaths is lower. By tracking underlying demographic denominators, the study permits quantification of absolute mortality rates

  15. Prospective Validation of Modified NEXUS Cervical Spine Injury Criteria in Low-risk Elderly Fall Patients

    OpenAIRE

    John Tran; Donald Jeanmonod; Darin Agresti; Khalief Hamden; Jeanmonod, Rebecca K.

    2016-01-01

    Introduction: The National Emergency X-radiography Utilization Study (NEXUS) criteria are used extensively in emergency departments to rule out C-spine injuries (CSI) in the general population. Although the NEXUS validation set included 2,943 elderly patients, multiple case reports and the Canadian C-Spine Rules question the validity of applying NEXUS to geriatric populations. The objective of this study was to validate a modified NEXUS criteria in a low-risk elderly fall population with two ...

  16. Newest-generation drug-eluting and bare-metal stents combined with prasugrel-based antiplatelet therapy in large coronary arteries

    DEFF Research Database (Denmark)

    Jeger, Raban; Pfisterer, Matthias; Alber, Hannes;

    2012-01-01

    In the BAsel Stent Kosten Effektivitäts Trial PROspective Validation Examination (BASKET-PROVE), drug-eluting stents (DESs) had similar 2-year rates of death and myocardial infarction but lower rates of target vessel revascularization and major adverse cardiac events compared with bare-metal stents...

  17. Nomogram predicting response after chemoradiotherapy in rectal cancer using sequential PETCT imaging: A multicentric prospective study with external validation

    International Nuclear Information System (INIS)

    Purpose: To develop and externally validate a predictive model for pathologic complete response (pCR) for locally advanced rectal cancer (LARC) based on clinical features and early sequential 18F-FDG PETCT imaging. Materials and methods: Prospective data (i.a. THUNDER trial) were used to train (N = 112, MAASTRO Clinic) and validate (N = 78, Università Cattolica del S. Cuore) the model for pCR (ypT0N0). All patients received long-course chemoradiotherapy (CRT) and surgery. Clinical parameters were age, gender, clinical tumour (cT) stage and clinical nodal (cN) stage. PET parameters were SUVmax, SUVmean, metabolic tumour volume (MTV) and maximal tumour diameter, for which response indices between pre-treatment and intermediate scan were calculated. Using multivariate logistic regression, three probability groups for pCR were defined. Results: The pCR rates were 21.4% (training) and 23.1% (validation). The selected predictive features for pCR were cT-stage, cN-stage, response index of SUVmean and maximal tumour diameter during treatment. The models’ performances (AUC) were 0.78 (training) and 0.70 (validation). The high probability group for pCR resulted in 100% correct predictions for training and 67% for validation. The model is available on the website (www.predictcancer.org). Conclusions: The developed predictive model for pCR is accurate and externally validated. This model may assist in treatment decisions during CRT to select complete responders for a wait-and-see policy, good responders for extra RT boost and bad responders for additional chemotherapy

  18. Early identification of struggling in medical education: a prospective cohort study of the validity of tutor judgments

    DEFF Research Database (Denmark)

    O'Neill, Lotte; Mørcke, Anne Mette; Eika, Berit

    2015-01-01

    controlling for grades obtained in preceeding exams. Lack of participation, lack of commitment, poor academic performance, poor social interactions and general signs of distress were the main indicators of struggling identified. Teachers’ informal judgements of in-class behavior may be an untapped source of...... early diagnosis of struggling in medical school based on informal teacher judgements of in-class behavior. The study design was a prospective cohort study and the outcome/truth criteria were anatomy failure and medical school drop out. Six weeks into a anatomy course, anatomy tutors attemted to identify...... signs of struggling. By week six, the tutors were able to detect approximately ¼-1/3 of the students who eventually failed or dropped out, and for ¾ of the strugglers they identified, they were correct in their judgments. Informal tutor judgements showed incremental validity for both outcomes when...

  19. A Prospective Validation Study of a Rainbow Model of Integrated Care Measurement Tool in Singapore

    Directory of Open Access Journals (Sweden)

    Milawaty Nurjono

    2016-01-01

    Full Text Available Introduction: The conceptual ambiguity of the integrated care concept precludes a full understanding of what constitutes a well-integrated health system, posing a significant challenge in measuring the level of integrated care. Most available measures have been developed from a disease-specific perspective and only measure certain aspects of integrated care. Based on the Rainbow Model of Integrated Care, which provides a detailed description of the complex concept of integrated care, a measurement tool has been developed to assess integrated care within a care system as a whole gathered from healthcare providers’ and managerial perspectives. This paper describes the methodology of a study seeking to validate the Rainbow Model of Integrated Care measurement tool within and across the Singapore Regional Health System. The Singapore Regional Health System is a recent national strategy developed to provide a better-integrated health system to deliver seamless and person-focused care to patients through a network of providers within a specified geographical region. Methods: The validation process includes the assessment of the content of the measure and its psychometric properties. Conclusion: If the measure is deemed to be valid, the study will provide the first opportunity to measure integrated care within Singapore Regional Health System with the results allowing insights in making recommendations for improving the Regional Health System and supporting international comparison.

  20. Operational Street Pollution Model (OSPM) - a review of performed validation studies, and future prospects

    DEFF Research Database (Denmark)

    Kakosimos K.E., Konstantinos E.; Hertel, Ole; Ketzel, Matthias;

    2010-01-01

    in this context is the fast and easy to apply Operational Street Pollution Model (OSPM). For almost 20 years, OSPM has been routinely used in many countries for studying traffic pollution, performing analyses of field campaign measurements, studying efficiency of pollution abatement strategies, carrying out...... exposure assessments and as reference in comparisons to other models. OSPM is generally considered as state-of-the-art in applied street pollution modelling. This paper outlines the most important findings in OSPM validation and application studies in literature. At the end of the paper, future research...

  1. Text data extraction for a prospective, research-focused data mart: implementation and validation

    Directory of Open Access Journals (Sweden)

    Hinchcliff Monique

    2012-09-01

    Full Text Available Abstract Background Translational research typically requires data abstracted from medical records as well as data collected specifically for research. Unfortunately, many data within electronic health records are represented as text that is not amenable to aggregation for analyses. We present a scalable open source SQL Server Integration Services package, called Regextractor, for including regular expression parsers into a classic extract, transform, and load workflow. We have used Regextractor to abstract discrete data from textual reports from a number of ‘machine generated’ sources. To validate this package, we created a pulmonary function test data mart and analyzed the quality of the data mart versus manual chart review. Methods Eleven variables from pulmonary function tests performed closest to the initial clinical evaluation date were studied for 100 randomly selected subjects with scleroderma. One research assistant manually reviewed, abstracted, and entered relevant data into a database. Correlation with data obtained from the automated pulmonary function test data mart within the Northwestern Medical Enterprise Data Warehouse was determined. Results There was a near perfect (99.5% agreement between results generated from the Regextractor package and those obtained via manual chart abstraction. The pulmonary function test data mart has been used subsequently to monitor disease progression of patients in the Northwestern Scleroderma Registry. In addition to the pulmonary function test example presented in this manuscript, the Regextractor package has been used to create cardiac catheterization and echocardiography data marts. The Regextractor package was released as open source software in October 2009 and has been downloaded 552 times as of 6/1/2012. Conclusions Collaboration between clinical researchers and biomedical informatics experts enabled the development and validation of a tool (Regextractor to parse, abstract and assemble

  2. Is determination between complete and incomplete traumatic spinal cord injury clinically relevant? Validation of the ASIA sacral sparing criteria in a prospective cohort of 432 patients.

    NARCIS (Netherlands)

    Middendorp, J.J. van; Hosman, A.J.F.; Pouw, M.H.; Meent, H. van de

    2009-01-01

    STUDY DESIGN: Prospective multicenter longitudinal cohort study. OBJECTIVE: To validate the prognostic value of the acute phase sacral sparing measurements with regard to chronic phase-independent ambulation in patients with traumatic spinal cord injury (SCI). SETTING: European Multicenter Study of

  3. Examination of the diagnostic validity of 'headache attributed to whiplash injury': a controlled, prospective study.

    Science.gov (United States)

    Schrader, H; Stovner, L J; Obelieniene, D; Surkiene, D; Mickeviciene, D; Bovim, G; Sand, T

    2006-11-01

    Acute and chronic headache attributed to whiplash injury are new diagnostic entities in the International Classification of Headache Disorders, second edition. A main objective of the present study was to assess the validity of these nosologic entities by studying the headache pattern in an inception cohort of 210 rear-end car collision victims and in 210 matched controls. Consecutive drivers involved in rear-end collisions were identified from the daily records of the Traffic Police Department of Kaunas, Lithuania. A standard self-report questionnaire was sent to the drivers between 2 and 7 days after the collision, and their passengers were recruited as well. Headache and neck pain were evaluated within 7 days of the collision, at 2 months and 1 year after the collision. A control group of non-traumatized subjects received questionnaires at the time of the selection and 1 year later. Of the 75 collision victims who developed headache within the first 7 days of the collision, 37 had a clinical picture in accordance with the criteria for acute whiplash headache (i.e., concomitant neck pain) and 38 did not. For acute headache after collision, concomitant neck pain was of no relevance to the headache type or its course. In both these subgroups, migraine and tension-type headache could be diagnosed in similar proportions and the prognosis after 2 months and 1 year was also similar. Preexisting headache was a strong prognostic factor in both groups for both acute and chronic pain. Compared with the non-traumatized control group, the 1-year incidence of new or worsened headache, or of headache improvement, was the same. A likely interpretation of the data is that acute headaches after rear-end car collisions mainly represent episodes of a primary headache precipitated by the stress of the situation. We conclude that the nosologic validity of both acute and chronic whiplash headache is poor as the headaches, in accordance with the criteria lack distinguishing clinical

  4. Validation of the RRE-90 Scale to Predict Stroke Risk after Transient Symptoms with Infarction: A Prospective Cohort Study.

    Directory of Open Access Journals (Sweden)

    Bo Song

    Full Text Available The risk of stroke after a transient ischemic attack (TIA for patients with a positive diffusion-weighted image (DWI, i.e., transient symptoms with infarction (TSI, is much higher than for those with a negative DWI. The aim of this study was to validate the predictive value of a web-based recurrence risk estimator (RRE; http://www.nmr.mgh.harvard.edu/RRE/ of TSI.Data from the prospective hospital-based TIA database of the First Affiliated Hospital of Zhengzhou University were analyzed. The RRE and ABCD2 scores were calculated within 7 days of symptom onset. The predictive outcome was ischemic stroke occurrence at 90 days. The receiver-operating characteristics curves were plotted, and the predictive value of the two models was assessed by computing the C statistics.A total of 221 eligible patients were prospectively enrolled, of whom 46 (20.81% experienced a stroke within 90 days. The 90-day stroke risk in high-risk TSI patients (RRE ≥4 was 3.406-fold greater than in those at low risk (P <0.001. The C statistic of RRE (0.681; 95% confidence interval [CI], 0.592-0.771 was statistically higher than that of ABCD2 score (0.546; 95% CI, 0.454-0.638; Z = 2.115; P = 0.0344 at 90 days.The RRE score had a higher predictive value than the ABCD2 score for assessing the 90-day risk of stroke after TSI.

  5. Prospective international validation of the Quality of Life in Myelodysplasia Scale (QUALMS)

    Science.gov (United States)

    Abel, Gregory A.; Efficace, Fabio; Buckstein, Rena J.; Tinsley, Sara; Jurcic, Joseph G.; Martins, Yolanda; Steensma, David. P; Watts, Corey D.; Raza, Azra; Lee, Stephanie J.; List, Alan F.; Klaassen, Robert J.

    2016-01-01

    Disease-specific measures of quality of life can improve assessment of disease-related symptoms and psychosocial sequelae. We report on the development and validation of the Quality of Life in Myelodysplasia Scale (QUALMS), a 38-item assessment tool for patients with myelodysplastic syndromes (MDS). In 2014–2015, a multi-center cohort of patients with myelodysplasia completed the QUALMS, as well as the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (QLQ-C30) and the Functional Assessment of Cancer Therapy Anemia Scale (FACT-An); a second administration was undertaken three to six months later. A total of 255 patients from the United States, Canada and Italy participated. Median age was 72 years, 56.1% were men, and the International Prognostic Scoring System distribution was 40.4% low, 42.0% intermediate-1, 13.3% intermediate-2 and 2.3% high. QUALMS scores ranged from 24 to 99 (higher scores are better), with a mean of 67.2 [standard deviation (SD)=15.2]. The measure was internally consistent (α=0.92), and moderately correlated with the multi-item QLQ-C30 scales and the FACT-An (r=−0.65 to 0.79; all Pmodern treatment era. PMID:26944474

  6. Prospective international validation of the Quality of Life in Myelodysplasia Scale (QUALMS).

    Science.gov (United States)

    Abel, Gregory A; Efficace, Fabio; Buckstein, Rena J; Tinsley, Sara; Jurcic, Joseph G; Martins, Yolanda; Steensma, David P; Watts, Corey D; Raza, Azra; Lee, Stephanie J; List, Alan F; Klaassen, Robert J

    2016-06-01

    Disease-specific measures of quality of life can improve assessment of disease-related symptoms and psychosocial sequelae. We report on the development and validation of the Quality of Life in Myelodysplasia Scale (QUALMS), a 38-item assessment tool for patients with myelodysplastic syndromes (MDS). In 2014-2015, a multi-center cohort of patients with myelodysplasia completed the QUALMS, as well as the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (QLQ-C30) and the Functional Assessment of Cancer Therapy Anemia Scale (FACT-An); a second administration was undertaken three to six months later. A total of 255 patients from the United States, Canada and Italy participated. Median age was 72 years, 56.1% were men, and the International Prognostic Scoring System distribution was 40.4% low, 42.0% intermediate-1, 13.3% intermediate-2 and 2.3% high. QUALMS scores ranged from 24 to 99 (higher scores are better), with a mean of 67.2 [standard deviation (SD)=15.2]. The measure was internally consistent (α=0.92), and moderately correlated with the multi-item QLQ-C30 scales and the FACT-An (r=-0.65 to 0.79; all P<0.001). Patients with hemoglobin of 8 g/dL or under scored lower than those with hemoglobin over 10 g/dL (61.8 vs 71.1; P<0.001), and transfusion-dependent patients scored lower than transfusion-independent patients (62.4 vs 69.7; P<0.01). Principal components analysis revealed "physical burden", "benefit-finding", and "emotional burden" subscales. There was good overall test-retest reliability among those with stable hemoglobin (r=0.81), and significant changes for patients hospitalized or with infections between administrations (both P<0.01). These data suggest the QUALMS is a valuable tool for assessing MDS-specific quality of life in the modern treatment era.

  7. Harmonizing FDG PET quantification while maintaining optimal lesion detection: prospective multicentre validation in 517 oncology patients

    Energy Technology Data Exchange (ETDEWEB)

    Quak, Elske [Francois Baclesse Cancer Centre, Nuclear Medicine Department, Caen (France); Le Roux, Pierre-Yves; Robin, Philippe; Bourhis, David; Salaun, Pierre-Yves [University Hospital and EA3878 (GETBO) IFR 148, Nuclear Medicine Department, Brest (France); Hofman, Michael S.; Callahan, Jason; Binns, David; Hicks, Rodney J. [East Melbourne and University of Melbourne, Centre for Molecular Imaging, Peter MacCallum Cancer Centre, Melbourne (Australia); Desmonts, Cedric [University Hospital, Nuclear Medicine Department, Caen (France); Aide, Nicolas [Francois Baclesse Cancer Centre, Nuclear Medicine Department, Caen (France); University Hospital, Nuclear Medicine Department, Caen (France); Francois Baclesse Cancer Centre, INSERM 1199, Caen (France); Normandie University, Caen (France)

    2015-12-15

    Point-spread function (PSF) or PSF + time-of-flight (TOF) reconstruction may improve lesion detection in oncologic PET, but can alter quantitation resulting in variable standardized uptake values (SUVs) between different PET systems. This study aims to validate a proprietary software tool (EQ.PET) to harmonize SUVs across different PET systems independent of the reconstruction algorithm used. NEMA NU2 phantom data were used to calculate the appropriate filter for each PSF or PSF+TOF reconstruction from three different PET systems, in order to obtain EANM compliant recovery coefficients. PET data from 517 oncology patients were reconstructed with a PSF or PSF+TOF reconstruction for optimal tumour detection and an ordered subset expectation maximization (OSEM3D) reconstruction known to fulfil EANM guidelines. Post-reconstruction, the proprietary filter was applied to the PSF or PSF+TOF data (PSF{sub EQ} or PSF+TOF{sub EQ}). SUVs for PSF or PSF+TOF and PSF{sub EQ} or PSF+TOF{sub EQ} were compared to SUVs for the OSEM3D reconstruction. The impact of potential confounders on the EQ.PET methodology including lesion and patient characteristics was studied, as was the adherence to imaging guidelines. For the 1380 tumour lesions studied, Bland-Altman analysis showed a mean ratio between PSF or PSF+TOF and OSEM3D of 1.46 (95 %CI: 0.86-2.06) and 1.23 (95 %CI: 0.95-1.51) for SUV{sub max} and SUV{sub peak}, respectively. Application of the proprietary filter improved these ratios to 1.02 (95 %CI: 0.88-1.16) and 1.04 (95 %CI: 0.92-1.17) for SUV{sub max} and SUV{sub peak}, respectively. The influence of the different confounding factors studied (lesion size, location, radial offset and patient's BMI) was less than 5 %. Adherence to the European Association of Nuclear Medicine (EANM) guidelines for tumour imaging was good. These data indicate that it is not necessary to sacrifice the superior lesion detection and image quality achieved by newer reconstruction techniques in

  8. Validating prediction scales of type 2 diabetes mellitus in Spain: the SPREDIA-2 population-based prospective cohort study protocol

    Science.gov (United States)

    Salinero-Fort, Miguel Ángel; de Burgos-Lunar, Carmen; Mostaza Prieto, José; Lahoz Rallo, Carlos; Abánades-Herranz, Juan Carlos; Gómez-Campelo, Paloma; Laguna Cuesta, Fernando; Estirado De Cabo, Eva; García Iglesias, Francisca; González Alegre, Teresa; Fernández Puntero, Belén; Montesano Sánchez, Luis; Vicent López, David; Cornejo Del Río, Víctor; Fernández García, Pedro J; Sabín Rodríguez, Concesa; López López, Silvia; Patrón Barandío, Pedro

    2015-01-01

    Introduction The incidence of type 2 diabetes mellitus (T2DM) is increasing worldwide. When diagnosed, many patients already have organ damage or advance subclinical atherosclerosis. An early diagnosis could allow the implementation of lifestyle changes and treatment options aimed at delaying the progression of the disease and to avoid cardiovascular complications. Different scores for identifying undiagnosed diabetes have been reported, however, their performance in populations of southern Europe has not been sufficiently evaluated. The main objectives of our study are: to evaluate the screening performance and cut-off points of the main scores that identify the risk of undiagnosed T2DM and prediabetes in a Spanish population, and to develop and validate our own predictive models of undiagnosed T2DM (screening model), and future T2DM (prediction risk model) after 5-year follow-up. As a secondary objective, we will evaluate the atherosclerotic burden of the population with undiagnosed T2DM. Methods and analysis Population-based prospective cohort study with baseline screening, to evaluate the performance of the FINDRISC, DANISH, DESIR, ARIC and QDScore, against the gold standard tests: Fasting plasma glucose, oral glucose tolerance and/or HbA1c. The sample size will include 1352 participants between the ages of 45 and 74 years. Analysis: sensitivity, specificity, positive predictive value, negative predictive value, likelihood ratio positive, likelihood ratio negative and receiver operating characteristic curves and area under curve. Binary logistic regression for the first 700 individuals (derivation) and last 652 (validation) will be performed. All analyses will be calculated with their 95% CI; statistical significance will be p<0.05. Ethics and dissemination The study protocol has been approved by the Research Ethics Committee of the Carlos III Hospital (Madrid). The score performance and predictive model will be presented in medical conferences, workshops

  9. Prospective, open-label study to validate proper use of the Versacloz™ (clozapine oral suspension kit by people with schizophrenia

    Directory of Open Access Journals (Sweden)

    Andre AD

    2015-05-01

    Full Text Available Anthony D Andre Interface Analysis Associates, Saratoga, CA, USA Purpose: This study was designed to validate that people with schizophrenia can correctly, safely, and effectively prepare doses of Versacloz™ using the Versacloz oral suspension kit and instructions for use (IFU.Materials and methods: This was a prospective, open-label, simulated-use validation study of 61 people with schizophrenia who were stabilized on clozapine or were clozapine-naive and stabilized on another antipsychotic treatment. Participants were randomized to one of two groups: untrained (n=46 and trained (n=15. Participants were asked to select the proper syringe and prepare two test doses of 1, 3.5, or 5 mL, as randomly assigned. Participants in the untrained group did not receive any training on using the kit, but had access to kit materials, including packaging and the IFU; both test dose preparations were unaided. Participants in the trained group received brief training from the moderator, and then prepared one test dose during training and one unaided test dose during the study period. Prepared placebo doses were not ingested. Performance and behavior were assessed in 14 critical tasks identified in the user failure mode and effects analysis. Test dose failures or dose errors (threshold ±0.1 mL were assessed. Subjective participant assessments of usability were captured in interviews and IFU comprehension was probed.Results: A total of 107 test doses were prepared: 92 and 15 by the untrained and trained groups, respectively. Overall success for unassisted dose preparation was 87.9%; all test failures (failure to shake the bottle or failure to obtain the correct test dose occurred in the untrained group. All participants selected the correct syringe for their assigned dose.Conclusion: This study shows that the Versacloz oral suspension kit and IFU can be correctly, safely, and effectively used to prepare doses by people with schizophrenia, with few instances of

  10. A Multicenter Prospective Validation Study for the Korean Thyroid Imaging Reporting and Data System in Patients with Thyroid Nodules

    Science.gov (United States)

    Ha, Eun Ju; Na, Dong Gyu; Lee, Young Hen; Choi, Nami; Kim, Soo Jin; Kim, Jae Kyun

    2016-01-01

    Objective To validate a new risk stratification system for thyroid nodules, the Korean Thyroid Imaging Reporting and Data System (K-TIRADS), using a prospective design. Materials and Methods From June 2013 to May 2015, 902 thyroid nodules were enrolled from four institutions. The type and predictive value of ultrasonography (US) predictors were analyzed according to the combination of the solidity and echogenicity of nodules; in addition, we determined malignancy risk and diagnostic performance for each category of K-TIRADS, and compared the efficacy of fine-needle aspiration (FNA) with a three-tier risk categorization system published in 2011. Results The malignancy risk was significantly higher in solid hypoechoic nodules, as compared to partially cystic or isohyperechoic nodules (each p < 0.001). The presence of any suspicious US features had a significantly higher malignancy risk (73.4%) in solid hypoechoic nodules than in partially cystic or isohyperechoic nodules (4.3–38.5%; p < 0.001). The calculated malignancy risk in K-TIRADS categories 5, 4, 3, and 2 nodules were 73.4, 19.0, 3.5, and 0.0%, respectively; and the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for malignancy were 95.5, 58.6, 44.5, 96.9, and 69.5%, respectively, in K-TIRADS categories 4 and 5. The efficacy of FNA for detecting malignancy based on K-TIRADS was increased from 18.6% (101/544) to 22.5% (101/449), as compared with the three-tier risk categorization system (p < 0.001). Conclusion The proposed new risk stratification system based on solidity and echogenicity was useful for risk stratification of thyroid nodules and the decision for FNA. The malignancy risk of K-TIRADS was in agreement with the findings of a previous retrospective study. PMID:27587972

  11. Saving time and money: a validation of the self ratings on the prospective NIMH life-chart method (NIMH-LCM)

    OpenAIRE

    Born, Christoph; Amann, Benedikt L; GRUNZE, HEINZ; Post, Robert M.; Schärer, Lars

    2014-01-01

    Background: Careful observation of the longitudinal course of bipolar disorders is pivotal to finding optimal treatments and improving outcome. A useful tool is the daily prospective Life-Chart Method, developed by the National Institute of Mental Health. However, it remains unclear whether the patient version is as valid as the clinician version. Methods: We compared the patient-rated version of the Lifechart (LC-self) with the Young-Mania-Rating Scale (YMRS), Inventory of Depressive Symptom...

  12. Predicting Reoffence in Sexual Offender Subtypes: A Prospective Validation Study of the German Version of the Sexual Offender Risk Appraisal Guide (SORAG)

    OpenAIRE

    Martin Rettenberger; Reinhard Eher

    2007-01-01

    This study is part of a prospective, longitudinal research project to evaluate the reliability and validity of different recidivism risk assessment methods for sexual offenders under community supervision for scientific and practical use in the German-speaking part of Europe. In this paper we present the German adaptation of the Sexual Offender Risk Appraisal Guide (SORAG), a specific risk assessment tool for sexual offenders that was developed and published in 1998 in Canada. We examined int...

  13. The High-Dose Aldesleukin “Select” Trial: A Trial to Prospectively Validate Predictive Models of Response Treatment in Patients with Metastatic Renal Cell Carcinoma

    Science.gov (United States)

    McDermott, David F.; Cheng, Su-Chun; Signoretti, Sabina; Margolin, Kim A.; Clark, Joseph I.; Sosman, Jeffrey A.; Dutcher, Janice P.; Logan, Theodore F.; Curti, Brendan D.; Ernstoff, Marc S.; Appleman, Leonard; Wong, Michael K.K.; Khushalani, Nikhil I.; Oleksowicz, Leslie; Vaishampayan, Ulka N.; Mier, James W.; Panka, David J.; Bhatt, Rupal S.; Bailey, Alexandra S.; Leibovich, Bradley C.; Kwon, Eugene D.; Kabbinavar, Fairooz F.; Belldegrun, Arie S.; Figlin, Robert A.; Pantuck, Allan J.; Regan, Meredith M.; Atkins, Michael B.

    2014-01-01

    Purpose High-dose aldesleukin (HD IL-2) received FDA approval for the treatment of mRCC in 1992, producing a 14% objective response rate (ORR) and durable remissions. Retrospective studies suggested that clinical and pathologic features could predict for benefit. The Cytokine Working Group conducted this prospective trial to validate proposed predictive markers of response to HD IL-2. Experimental Design Standard HD IL-2 was administered to prospectively evaluate whether the ORR of mRCC patients with “good” predictive pathologic features based on an “integrated selection” model (ISM) (e.g. clear-cell histology sub-classification and carbonic anhydrase-9 (CA-9) IHC staining) was significantly higher than the ORR of a historical, unselected population. Archived tumor was collected for pathologic analysis including tumor programmed death-ligand 1 (PD-L1) expression. Results 120 eligible patients enrolled between 11/06 and 7/09; 70% were MSKCC intermediate risk, 96% had clear cell RCC and 99% had prior nephrectomy. The independently assessed ORR was 25% (30/120, 95% CI = 17.5%–33.7%, p=0.0014) (3 CR, 27 PR) and was higher than a historical ORR. Thirteen patients (11%) remained progression-free at 3 years and the median OS was 42.8 months. ORR was not statistically different by ISM classification (“good-risk” 23% vs. “poor-risk” 30%, (p=0.39)). ORR was positively associated with tumor PD-L1 expression (p=0.01) by IHC. Conclusions In this prospective, biomarker validation study, HD IL-2 produced durable remissions and prolonged survival in both “good” and “poor-risk” patients. The proposed ISM was unable to improve the selection criteria. Novel markers (e.g. tumor PD-L1expression) appeared useful, but require independent validation. PMID:25424850

  14. Predicting Reoffence in Sexual Offender Subtypes: A Prospective Validation Study of the German Version of the Sexual Offender Risk Appraisal Guide (SORAG

    Directory of Open Access Journals (Sweden)

    Martin Rettenberger

    2007-12-01

    Full Text Available This study is part of a prospective, longitudinal research project to evaluate the reliability and validity of different recidivism risk assessment methods for sexual offenders under community supervision for scientific and practical use in the German-speaking part of Europe. In this paper we present the German adaptation of the Sexual Offender Risk Appraisal Guide (SORAG, a specific risk assessment tool for sexual offenders that was developed and published in 1998 in Canada. We examined interrater reliability, concurrent validity and predictive validity of the German version of the instrument with a sample of 254 male sexual offenders arrested in the Austrian penal system. The German SORAG showed good results for interrater reliability and concurrent validity. The predictive validity was determined using subgroups of the sample based on each offender’s index offence. The results were predominantly good, but the ability of the instrument to predict sexual and violent recidivism varied depending on offender type. The best results could be obtained for the prediction of re-imprisonment. The conclusion of this study is that the German version of the SORAG performs equally well and is most useful in predicting serious reoffenses.

  15. Prospective validation of a risk calculator which calculates the probability of a positive prostate biopsy in a contemporary clinical cohort

    NARCIS (Netherlands)

    van Vugt, Heidi A.; Kranse, Ries; Steyerberg, Ewout W.; van der Poel, Henk G.; Busstra, Martijn; Kil, Paul; Oomens, Eric H.; de Jong, Igle J.; Bangma, Chris H.; Roobol, Monique J.

    2012-01-01

    Background: Prediction models need validation to assess their value outside the development setting. Objective: To assess the external validity of the European Randomised study of Screening for Prostate Cancer (ERSPC) Risk Calculator (RC) in a contemporary clinical cohort. Methods: The RC calculates

  16. A Multi-Center Prospective Derivation and Validation of a Clinical Prediction Tool for Severe Clostridium difficile Infection.

    LENUS (Irish Health Repository)

    Na, Xi

    2015-04-23

    Prediction of severe clinical outcomes in Clostridium difficile infection (CDI) is important to inform management decisions for optimum patient care. Currently, treatment recommendations for CDI vary based on disease severity but validated methods to predict severe disease are lacking. The aim of the study was to derive and validate a clinical prediction tool for severe outcomes in CDI.

  17. The Validity and Utility of the California Family Risk Assessment under Practice Conditions in the Field: A Prospective Study

    Science.gov (United States)

    Johnson, Will L.

    2011-01-01

    Objective: Analysis of the validity and implementation of a child maltreatment actuarial risk assessment model, the California Family Risk Assessment (CFRA). Questions addressed: (1) Is there evidence of the validity of the CFRA under field operating conditions? (2) Do actuarial risk assessment results influence child welfare workers' service…

  18. Prospective validation of immunological infiltrate for prediction of response to neoadjuvant chemotherapy in HER2-negative breast cancer--a substudy of the neoadjuvant GeparQuinto trial.

    Directory of Open Access Journals (Sweden)

    Yasmin Issa-Nummer

    Full Text Available INTRODUCTION: We have recently described an increased lymphocytic infiltration rate in breast carcinoma tissue is a significant response predictor for anthracycline/taxane-based neoadjuvant chemotherapy (NACT. The aim of this study was to prospectively validate the tumor-associated lymphocyte infiltrate as predictive marker for response to anthracycline/taxane-based NACT. PATIENTS AND METHODS: The immunological infiltrate was prospectively evaluated in a total of 313 core biopsies from HER2 negative patients of the multicenter PREDICT study, a substudy of the neoadjuvant GeparQuinto study. Intratumoral lymphocytes (iTuLy, stromal lymphocytes (strLy as well as lymphocyte-predominant breast cancer (LPBC were evaluated by histopathological assessment. Pathological complete response (pCR rates were analyzed and compared between the defined subgroups using the exact test of Fisher. RESULTS: Patients with lymphocyte-predominant breast cancer (LPBC had a significantly increased pCR rate of 36.6%, compared to non-LPBC patients (14.3%, p<0.001. LPBC and stromal lymphocytes were significantly independent predictors for pCR in multivariate analysis (LPBC: OR 2.7, p = 0.003, strLy: OR 1.2, p = 0.01. The amount of intratumoral lymphocytes was significantly predictive for pCR in univariate (OR 1.2, p = 0.01 but not in multivariate logistic regression analysis (OR 1.2, p = 0.11. CONCLUSION: Confirming previous investigations of our group, we have prospectively validated in an independent cohort that an increased immunological infiltrate in breast tumor tissue is predictive for response to anthracycline/taxane-based NACT. Patients with LPBC and increased stromal lymphocyte infiltration have significantly increased pCR rates. The lymphocytic infiltrate is a promising additional parameter for histopathological evaluation of breast cancer core biopsies.

  19. Predictive validity of the UK clinical aptitude test in the final years of medical school: a prospective cohort study

    OpenAIRE

    Husbands, Adrian; Mathieson, Alistair; Dowell, Jonathan; Cleland, Jennifer; MacKenzie, Rhoda

    2014-01-01

    Background The UK Clinical Aptitude Test (UKCAT) was designed to address issues identified with traditional methods of selection. This study aims to examine the predictive validity of the UKCAT and compare this to traditional selection methods in the senior years of medical school. This was a follow-up study of two cohorts of students from two medical schools who had previously taken part in a study examining the predictive validity of the UKCAT in first year. Methods The sample consisted of ...

  20. Validation of control of allergic rhinitis and asthma test for children (CARATKids)--a prospective multicenter study

    OpenAIRE

    Linhares, DV; fonseca, ja; Borrego, LM; Matos, A; Pereira, AM; Sá-Sousa, A; Gaspar, A.; Mendes, C; Moreira, C.; Gomes, E; Rebelo, FF; Cidrais-Rodrigues, JC; Onofre, JM; Azevedo, LF; Alfaro, M

    2014-01-01

    BACKGROUND: Control of Allergic Rhinitis and Asthma Test for Children (CARATKids) is the first questionnaire that assesses simultaneously allergic rhinitis and asthma control in children. It was recently developed, but redundancy of questions and its psychometric properties were not assessed. This study aimed to (i) establish the final version of the CARATKids questionnaire and (ii) evaluate its reliability, responsiveness, cross-sectional validity, and longitudinal validity. METHODS: ...

  1. Validation of self-reported motor-vehicle crash and related work leave in a multi-purpose prospective cohort.

    Science.gov (United States)

    Pons-Villanueva, Juan; Seguí-Gómez, María

    2010-12-01

    Validation studies about self-reported motor vehicle crashes and related work leave are scarce. The Seguimiento Universidad de Navarra (SUN) is a multi-purpose cohort study undertaken in Spain. Motor vehicle crash risk factors are assessed within it. The objective of this study was to validate the incidents of self-reported motor vehicle crashes (MVC) and related work leave through mailing and clinical notes' review. The method included questions in the cohort's questionnaire regarding motor vehicle crash incident and work leave. We made both a re-test and a criterion validity study for self-reported answers. The results show a moderate κ Cohen's correlation coefficient for both events. Re-test reliability κ for MVC was 0.55, for MVC-related work leave it was 0.53. Criterion validity κ was 0.25 for MVC and 0.25 for MVC-related work leave. These results show a moderate agreement for re-test both for MVC and work MVC-related leave. For criterion validity, the results show a fair agreement. The magnitude of the agreement is similar to other similar studies and allows the use of these data in epidemiological studies.

  2. Derivation and validation of two decision instruments for selective chest CT in blunt trauma: a multicenter prospective observational study (NEXUS Chest CT.

    Directory of Open Access Journals (Sweden)

    Robert M Rodriguez

    2015-10-01

    Full Text Available Unnecessary diagnostic imaging leads to higher costs, longer emergency department stays, and increased patient exposure to ionizing radiation. We sought to prospectively derive and validate two decision instruments (DIs for selective chest computed tomography (CT in adult blunt trauma patients.From September 2011 to May 2014, we prospectively enrolled blunt trauma patients over 14 y of age presenting to eight US, urban level 1 trauma centers in this observational study. During the derivation phase, physicians recorded the presence or absence of 14 clinical criteria before viewing chest imaging results. We determined injury outcomes by CT radiology readings and categorized injuries as major or minor according to an expert-panel-derived clinical classification scheme. We then employed recursive partitioning to derive two DIs: Chest CT-All maximized sensitivity for all injuries, and Chest CT-Major maximized sensitivity for only major thoracic injuries (while increasing specificity. In the validation phase, we employed similar methodology to prospectively test the performance of both DIs. We enrolled 11,477 patients-6,002 patients in the derivation phase and 5,475 patients in the validation phase. The derived Chest CT-All DI consisted of (1 abnormal chest X-ray, (2 rapid deceleration mechanism, (3 distracting injury, (4 chest wall tenderness, (5 sternal tenderness, (6 thoracic spine tenderness, and (7 scapular tenderness. The Chest CT-Major DI had the same criteria without rapid deceleration mechanism. In the validation phase, Chest CT-All had a sensitivity of 99.2% (95% CI 95.4%-100%, a specificity of 20.8% (95% CI 19.2%-22.4%, and a negative predictive value (NPV of 99.8% (95% CI 98.9%-100% for major injury, and a sensitivity of 95.4% (95% CI 93.6%-96.9%, a specificity of 25.5% (95% CI 23.5%-27.5%, and a NPV of 93.9% (95% CI 91.5%-95.8% for either major or minor injury. Chest CT-Major had a sensitivity of 99.2% (95% CI 95.4%-100%, a specificity of

  3. Prospective validation of two models for ultrasonographic diagnosis of cirrhosis Validación prospectiva de dos modelos de diagnóstico de cirrosis hepática mediante ultrasonografía

    OpenAIRE

    Manuel Alberto Macías-Rodríguez; Paloma Rendón-Unceta; María Teresa Ramos-Clemente-Romero; Luis Manuel Troiteiro-Carrasco; María Dolores Serrano-León

    2011-01-01

    Objective: to perform a prospective validation and comparative analysis of two ultrasonographic diagnostic scores of cirrhosis in patients with silent liver disease. Design: cross-sectional study, prospective and blind. ROC curves evaluated the diagnostic utility of: a) Bologna score (BS): assessment of liver surface nodularity and portal flow velocity, and b) Cadiz score (CS): assessment of liver echostructure, portal vein caliber and spleen area. Liver biopsy was considered the gold standar...

  4. Validity and reproducibility of self-administered joint counts. A prospective longitudinal followup study in patients with rheumatoid arthritis

    NARCIS (Netherlands)

    Prevoo, MLL; Kuper, IH; vantHof, MA; vanLeeuwen, MA; vandePutte, LBA; vanRiel, PLCM

    1996-01-01

    Objective. To investigate the reproducibility and validity of self-administered joint counts (JC), measuring tenderness, swelling and the combination of both, in a longitudinal study, Methods. At the outpatient department a form self-administered by patients (SAI-form), was used to measure joint inv

  5. The validity of student tutors’ judgments in early detection of struggling in medical school. A prospective cohort study

    DEFF Research Database (Denmark)

    O'Neill, Lotte; Mørcke, Anne Mette; Eika, Berit

    2016-01-01

    validity for both outcomes when controlling for grades obtained in preceeding exams. Lack of participation, lack of commitment, poor academic performance, poor social interactions and general signs of distress were the main indicators of struggling identified. Teachers’ informal judgements of in...

  6. External Validation and Calibration of IVFpredict: A National Prospective Cohort Study of 130,960 In Vitro Fertilisation Cycles

    OpenAIRE

    Smith, Andrew D.A.C.; Kate Tilling; Debbie A Lawlor; Nelson, Scott M

    2015-01-01

    Background: Accurately predicting the probability of a live birth after in vitro fertilisation (IVF) is important for patients, healthcare providers and policy makers. Two prediction models (Templeton and IVFpredict) have been previously developed from UK data and are widely used internationally. The more recent of these, IVFpredict, was shown to have greater predictive power in the development dataset. The aim of this study was external validation of the two models and comparison of thei...

  7. Validation of the Spanish Version of the Eating Assessment Tool-10 (EAT-10spa) in Colombia. A Blinded Prospective Cohort Study.

    Science.gov (United States)

    Giraldo-Cadavid, Luis Fernando; Gutiérrez-Achury, Alejandra María; Ruales-Suárez, Karem; Rengifo-Varona, Maria Leonor; Barros, Camilo; Posada, Andrés; Romero, Carlos; Galvis, Ana María

    2016-06-01

    Dysphagia might affect 12 % of the general population, and its complications include pneumonia, malnutrition, social isolation, and death. No validated Spanish symptom survey exists to quantify dysphagia symptoms among Latin Americans. Therefore, we performed a prospective cohort study in a tertiary care university hospital to validate the Spanish version of the 10-Item Eating-Assessment-Tool (EAT-10spa) for use in Colombia. After an interdisciplinary committee of five bilingual specialists evaluated the EAT-10spa (translated and validated in Spain) and deemed it appropriate for the Colombian culture, its feasibility, reliability, validity, sensitivity to change, and diagnostic capacity were evaluated. As a reference standard, we used the flexible endoscopic evaluation of swallowing with sensory testing and a standardized clinical evaluation. All assessments were blinded. In total, 133 subjects were included (52 % women, mean age 55 years) and completed the EAT-10spa (median completion time: 2 min [IQR 1-3 min]), 39 % of whom had an elementary-level education. Cronbach's α coefficient: 0.91; test-retest intra-class correlation coefficient: 0.94. The Spearman's correlation coefficient of the EAT-10spa with the 8-point penetration-aspiration scale was 0.54 (P EAT-10spa ≥2 (sensitivity 93.6 %, specificity 36.4 %) and EAT-10spa ≥4 (sensitivity 94.3 %, specificity 49.5 %), respectively. A reduction in the EAT-10 ≥3 was the best cut-off point for a clinically significant improvement (AUC-ROC 0.83; P EAT-10spa showed excellent psychometric properties and discriminatory capacity for use in Colombia.

  8. Use of the SONET Score to Evaluate High Volume Emergency Department Overcrowding: A Prospective Derivation and Validation Study

    Directory of Open Access Journals (Sweden)

    Hao Wang

    2015-01-01

    Full Text Available Background. The accuracy and utility of current Emergency Department (ED crowding estimation tools remain uncertain in EDs with high annual volumes. We aimed at deriving a more accurate tool to evaluate overcrowding in a high volume ED setting and determine the association between ED overcrowding and patient care outcomes. Methods. A novel scoring tool (SONET: Severely overcrowded-Overcrowded-Not overcrowded Estimation Tool was developed and validated in two EDs with both annual volumes exceeding 100,000. Patient care outcomes including the number of left without being seen (LWBS patients, average length of ED stay, ED 72-hour returns, and mortality were compared under the different crowding statuses. Results. The total number of ED patients, the number of mechanically ventilated patients, and patient acuity levels were independent risk factors affecting ED overcrowding. SONET was derived and found to better differentiate severely overcrowded, overcrowded, and not overcrowded statuses with similar results validated externally. In addition, SONET scores correlated with increased length of ED stay, number of LWBS patients, and ED 72-hour returns. Conclusions. SONET might be a better fit to determine high volume ED overcrowding. ED overcrowding negatively impacts patient care operations and often produces poor patient perceptions of standardized care delivery.

  9. Seven-Day Mortality Can Be Predicted in Medical Patients by Blood Pressure, Age, Respiratory Rate, Loss of Independence, and Peripheral Oxygen Saturation (the PARIS Score): A Prospective Cohort Study with External Validation

    OpenAIRE

    Mikkel Brabrand; Annmarie Touborg Lassen; Torben Knudsen; Jesper Hallas

    2015-01-01

    Background Most existing risk stratification systems predicting mortality in emergency departments or admission units are complex in clinical use or have not been validated to a level where use is considered appropriate. We aimed to develop and validate a simple system that predicts seven-day mortality of acutely admitted medical patients using routinely collected variables obtained within the first minutes after arrival. Methods and Findings This observational prospective cohort study used t...

  10. External validation and calibration of IVFpredict: a national prospective cohort study of 130,960 in vitro fertilisation cycles.

    Directory of Open Access Journals (Sweden)

    Andrew D A C Smith

    Full Text Available Accurately predicting the probability of a live birth after in vitro fertilisation (IVF is important for patients, healthcare providers and policy makers. Two prediction models (Templeton and IVFpredict have been previously developed from UK data and are widely used internationally. The more recent of these, IVFpredict, was shown to have greater predictive power in the development dataset. The aim of this study was external validation of the two models and comparison of their predictive ability.130,960 IVF cycles undertaken in the UK in 2008-2010 were used to validate and compare the Templeton and IVFpredict models. Discriminatory power was calculated using the area under the receiver-operator curve and calibration assessed using a calibration plot and Hosmer-Lemeshow statistic. The scaled modified Brier score, with measures of reliability and resolution, were calculated to assess overall accuracy. Both models were compared after updating for current live birth rates to ensure that the average observed and predicted live birth rates were equal. The discriminative power of both methods was comparable: the area under the receiver-operator curve was 0.628 (95% confidence interval (CI: 0.625-0.631 for IVFpredict and 0.616 (95% CI: 0.613-0.620 for the Templeton model. IVFpredict had markedly better calibration and higher diagnostic accuracy, with calibration plot intercept of 0.040 (95% CI: 0.017-0.063 and slope of 0.932 (95% CI: 0.839-1.025 compared with 0.080 (95% CI: 0.044-0.117 and 1.419 (95% CI: 1.149-1.690 for the Templeton model. Both models underestimated the live birth rate, but this was particularly marked in the Templeton model. Updating the models to reflect improvements in live birth rates since the models were developed enhanced their performance, but IVFpredict remained superior.External validation in a large population cohort confirms IVFpredict has superior discrimination and calibration for informing patients, clinicians and

  11. Prospective validation of a comprehensive in silico hERG model and its applications to commercial compound and drug databases.

    Science.gov (United States)

    Doddareddy, Munikumar R; Klaasse, Elisabeth C; Shagufta; Ijzerman, Adriaan P; Bender, Andreas

    2010-05-01

    Ligand-based in silico hERG models were generated for 2 644 compounds using linear discriminant analysis (LDA) and support vector machines (SVM). As a result, the dataset used for the model generation is the largest publicly available (see Supporting Information). Extended connectivity fingerprints (ECFPs) and functional class fingerprints (FCFPs) were used to describe chemical space. All models showed area under curve (AUC) values ranging from 0.89 to 0.94 in a fivefold cross-validation, indicating high model consistency. Models correctly predicted 80 % of an additional, external test set; Y-scrambling was also performed to rule out chance correlation. Additionally models based on patch clamp data and radioligand binding data were generated separately to analyze their predictive ability when compared to combined models. To experimentally validate the models, 50 of the predicted hERG blockers from the Chembridge database and ten of the predicted non-hERG blockers from an in-house compound library were selected for biological evaluation. Out of those 50 predicted hERG blockers, tested at a concentration of 10 microM, 18 compounds showed more than 50 % displacement of [(3)H]astemizole binding to cell membranes expressing the hERG channel. K(i) values of four of the selected binders were determined to be in the micromolar and high nanomolar range (K(i) (VH01)=2.0 microM, K(i) (VH06)=0.15 microM, K(i) (VH19)=1.1 microM and K(i) (VH47)=18 microM). Of these four compounds, VH01 and VH47 showed also a second, even higher affinity binding site with K(i) values of 7.4 nM and 36 nM, respectively. In the case of non-hERG blockers, all ten compounds tested were found to be inactive, showing less than 50 % displacement of [(3)H]astemizole binding at 10 microM. These experimentally validated models were then used to virtually screen commercial compound databases to evaluate whether they contain hERG blockers. 109 784 (23 %) of Chembridge, 133 175 (38 %) of Chemdiv, 111 737 (31

  12. Validity and reliability of the braden scale and the influence of other risk factors: a multi-centre prospective study.

    Science.gov (United States)

    Halfens, R J; Van Achterberg, T; Bal, R M

    2000-08-01

    The Braden scale is one of the most intensively studied risk assessment scales used in identifying the risk of developing pressure sores. However, not all studies show that the sensitivity and specificity of this scale is sufficient. This study, therefore, investigated whether adding new risk factors can enhance the sensitivity and specificity of the Braden scale. The Braden scale was tested in a prospective multi-centre design. The nurses of 11 wards filled in the Braden scale every 5 days for each patient who was admitted without pressure sores and who had a probable stay of at least 10 days. Based on a literature study and in-depth interviews with experts, the Braden scale was extended by the risk factor blood circulation. In addition, other risk factors, which are more or less stable patient characteristics, were measured during the admission of the patient. Independent research assistants measured the presence of pressure sores twice a week. As the external criterion for the risk of developing pressure sores, the presence of pressure sores and/or the use of preventive activities was used. Results showed that the original Braden scale was a reliable instrument and that the sensitivity and specificity was sufficient. However, reformulating the factors moisture and nutrition, and adding the risk factor age could enhance the sensitivity and specificity. Furthermore, results showed that the factors sensory perception, and friction and shear were especially important risk factors for the Braden scale. In fact, using only the factors sensory perception, friction and shear, moisture (a reformulated factor) and age give the highest explained variance of the risk of developing pressure sores. The added risk factor blood circulation, did not enhance the sensitivity and specificity of the original Braden scale. Suggestions are given on how to use risk assessment scales in practice.

  13. Healthy Team Healthy U: A Prospective Validation of an Evidence-based Worksite Health Promotion and Wellness Platform

    Directory of Open Access Journals (Sweden)

    Linn eGoldberg

    2015-08-01

    Full Text Available Objective: To evaluate the effects of a research tested, team-based health promotion and wellness program combined with digital technologies and implemented in a diverse worksite setting among hospital, clinic and university employees. Methods: A prospective cohort study of employees completing biometrics and questionnaires before and after the initial 12-session wellness program and its 12-session booster, one year later. Results: After both the initial intervention and booster, blood pressure and weight were reduced, with greater reductions among employees with pre-hypertension and hypertension and those with a BMI > 25. After both the initial intervention and booster, there was a significant increase in, 1 daily intake of fruit and vegetable servings; 2 days per week of > 30 minutes of exercise; 3 days per week of strength training and 4 levels of moderately vigorous and vigorous daily physical activity. Self-reported indices of depression and work related stress were reduced, while participants reported increased happiness after the initial program and booster. Post booster, average sleep quality and sleep duration increased, among higher risk employees reporting < 6 hours of daily sleep. Employees reported receiving encouragement from co-workers to engage in healthful activities, exercising with fellow employees more, and indicated they would recommend the program to co-workers. Longitudinal analysis revealed the durability of the initial intervention outcomes with further beneficial effects after the booster. Conclusion: A research-tested, comprehensive team-based health promotion and wellness program, combined with digital technologies, positively impacted employee health behaviors, mood, sleep, worker cohesion and biometrics among a diverse multi-site workforce. Positive program effects were durable, with enhanced results after the booster.

  14. A clinicopathological study of early-stage synchronous bilateral breast cancer: a retrospective evaluation and prospective validation of potential risk factors.

    Directory of Open Access Journals (Sweden)

    Jia-Jian Chen

    Full Text Available BACKGROUND: The aim of the present study was to investigate potential risk factors for synchronous bilateral breast cancer sBBC. METHODS: A retrospective analysis was performed of patients diagnosed and treated with operable bilateral breast cancer (BBC between June 2007 and December 2011. Risk factors for sBBC were evaluated in this cohort and further validated in a prospective observational validation analysis of patients between January 2012 and December 2012. Patients treated with operable unilateral breast cancer during the same period were used as a control group. RESULTS: A total of 11,247 patients with primary breast cancer underwent operations at the Fudan University Shanghai Cancer Center between June 2007 and December 2012. The incidence of sBBC was 1.6%. The age at diagnosis (HR = 2.4, 95% C.I.: 1.4-4.0, p = 0.001, presence of sclerosing adenosis (HR = 11.8, 95% C.I.: 5.3-26.3, p<0.001, lobular carcinoma component involvement (HR = 5.6, 95% C.I.: 2.6-12.1, p<0.001, and family history of first-degree relatives with breast cancer (HR = 2.0, 95% C.I.: 1.1-3.4, p<0.001 were independent risk factors for sBBC. A subsequent validation study failed to confirm the significance of family history. No significant difference on survival was found between patients with early-stage sBBC and control cases. CONCLUSIONS: Patients with the presence of sclerosing in the affected breast, and lobular carcinoma component involvement may be at high risk for developing sBBC. This study supports the hypothesis that the host-carcinoma biological relationship, especially for the tumor microenvironment, played a critical role in the carcinogenesis of sBBC.

  15. Validation of the Spanish Version of the Eating Assessment Tool-10 (EAT-10spa) in Colombia. A Blinded Prospective Cohort Study.

    Science.gov (United States)

    Giraldo-Cadavid, Luis Fernando; Gutiérrez-Achury, Alejandra María; Ruales-Suárez, Karem; Rengifo-Varona, Maria Leonor; Barros, Camilo; Posada, Andrés; Romero, Carlos; Galvis, Ana María

    2016-06-01

    Dysphagia might affect 12 % of the general population, and its complications include pneumonia, malnutrition, social isolation, and death. No validated Spanish symptom survey exists to quantify dysphagia symptoms among Latin Americans. Therefore, we performed a prospective cohort study in a tertiary care university hospital to validate the Spanish version of the 10-Item Eating-Assessment-Tool (EAT-10spa) for use in Colombia. After an interdisciplinary committee of five bilingual specialists evaluated the EAT-10spa (translated and validated in Spain) and deemed it appropriate for the Colombian culture, its feasibility, reliability, validity, sensitivity to change, and diagnostic capacity were evaluated. As a reference standard, we used the flexible endoscopic evaluation of swallowing with sensory testing and a standardized clinical evaluation. All assessments were blinded. In total, 133 subjects were included (52 % women, mean age 55 years) and completed the EAT-10spa (median completion time: 2 min [IQR 1-3 min]), 39 % of whom had an elementary-level education. Cronbach's α coefficient: 0.91; test-retest intra-class correlation coefficient: 0.94. The Spearman's correlation coefficient of the EAT-10spa with the 8-point penetration-aspiration scale was 0.54 (P < 0.001). The area under the receiver-operating-characteristic-curve (AUC-ROC) for dysphagia and aspiration were 0.79 (P < 0.001) and 0.81 (P < 0.001), respectively. The best cut-off points for dysphagia and aspiration were EAT-10spa ≥2 (sensitivity 93.6 %, specificity 36.4 %) and EAT-10spa ≥4 (sensitivity 94.3 %, specificity 49.5 %), respectively. A reduction in the EAT-10 ≥3 was the best cut-off point for a clinically significant improvement (AUC-ROC 0.83; P < 0.0001). The EAT-10spa showed excellent psychometric properties and discriminatory capacity for use in Colombia. PMID:26803775

  16. Validity of information on atopic disease and other illness in young children reported by parents in a prospective birth cohort study

    Directory of Open Access Journals (Sweden)

    Vissing Nadja

    2012-10-01

    Full Text Available Abstract Background The longitudinal birth cohort study is the preferred design for studies of childhood health, particularly atopic disease. Still, prospective data collection depends on recollection of the medical history since the previous visit representing a potential recall-bias. We aimed to ascertain the quality of information on atopic disease and other health symptoms reported by parental interview in a closely monitored birth cohort study. Possible bias from symptom severity and socioeconomics were sought. Methods Copenhagen study on Asthma in Childhood (COPSAC is a clinical birth cohort study of 411 children born of asthmatic mothers from 1999 to 2001. Child health is monitored at six-monthly visits with particular emphasis on atopic symptoms and infections. Data from the first three study years on 260 children was compared with records from their family practitioner as an external reference. Results A total of 6134 medical events were reported at the COPSAC interviews. Additional 586 medical events were recorded by family practitioners but not reported at the interview. There were no missed events related to asthma, eczema or allergy. Respiratory, infectious and skin related symptoms showed completeness above 90%, other diseases showed lower completeness around 77%. There was no meaningful influence from concurrent asthma or socioeconomics. Conclusions The COPSAC study exhibited full sensitivity to the main study objectives, atopic disease, and high sensitivity to respiratory, infectious and skin related illness. Our findings support the validity of parental interviews in longitudinal cohort studies investigating atopic disease and illness in childhood.

  17. Prospective validation of FibroTest in comparison with liver stiffness for predicting liver fibrosis in Asian subjects with chronic hepatitis B.

    Directory of Open Access Journals (Sweden)

    Beom Kyung Kim

    Full Text Available Diagnostic values of FibroTest (FT for hepatic fibrosis have rarely been assessed in Asian chronic hepatitis B (CHB patients. We aimed to validate its diagnostic performances in comparison with liver stiffness (LS.From 2008 to 2010, 194 CHB patients who underwent liver biopsies along with FT and transient elastography were prospectively enrolled. Fibrosis stage was assessed according to the Batts and Ludwig system.To predict significant fibrosis (F≥2, advanced fibrosis (F≥3, and cirrhosis (F = 4, areas under receiver operating characteristic curves (AUROCs of FT were 0.903, 0.907, and 0.866, comparable to those of LS (0.873, 0.897, and 0.910, respectively. Optimized cutoffs of FT to maximize sum of sensitivity and specificity were 0.32, 0.52, and 0.68 for F≥2, F≥3, and F = 4, while those of LS were 8.8, 10.2, and 14.1 kPa, respectively. According to FT and LS cutoffs, 123 (63.4% and 124 (63.9% patients were correctly classified consistent with histological fibrosis (F1, F2, F3, and F4, respectively. Overall concordance between each fibrosis stage estimated by FT and LS was observed in 111 patients, where 88 were correctly classified with histological results. A combination formula adding LS to FT (LS+FT showed similar AUROC levels (0.885, 0.905, and 0.915, while another multiplying LS by FT (LS×FT showed the best AUROCs (0.941, 0.931, and 0.929 for F≥2, F≥3, and F4, respectively.FT provides good fibrosis prediction, with comparable outcomes to LS in Asian CHB patients. FT substantially reduces need for liver biopsy, especially when used in combination with LS.

  18. Perfusion-metabolism coupling in recurrent gliomas: a prospective validation study with {sup 13}N-ammonia and {sup 18}F-fluorodeoxyglucose PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Khangembam, Bangkim Chandra; Karunanithi, Sellam; Sharma, Punit; Kc, Sudhir Suman; Kumar, Rajeev; Kumar, Rakesh; Bal, Chandrasekhar [All India Institute of Medical Sciences, Department of Nuclear Medicine, Ansari Nagar, New Delhi (India); Julka, Pramod Kumar [All India Institute of Medical Sciences, Department of Radiation Oncology, New Delhi (India)

    2014-10-15

    We assessed the validity of ''perfusion-metabolism coupling'' hypothesis in recurrent glioma with {sup 13}N-ammonia ({sup 13}N-NH{sub 3}) PET/CT and {sup 18}F-fluorodeoxyglucose ({sup 18}F-FDG) PET/CT. Fifty-six consecutive patients (age, 38.8 ± 12.1 years; 62.5 % males) with histologically proven and previously treated glioma presenting with clinical suspicion of recurrence were prospectively enrolled and evaluated with {sup 13}N-NH{sub 3} PET/CT and {sup 18}F-FDG PET/CT. PET/CT images were evaluated both qualitatively and semiquantitatively. Tumor to white matter uptake ratio (T/W) and tumor to gray matter uptake ratio (T/G) were calculated and analyzed for both the modalities. A combination of clinico-radiological follow-up, repeated imaging, and biopsy (when available) were considered as the reference standard. Based on the reference standard, 27/56 patients had recurrence. {sup 13}N-NH{sub 3} PET/CT and {sup 18}F-FDG PET/CT were concordant in 55/56 patients. Overall sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of {sup 13}N-NH{sub 3}PET/CT were 77.8, 86.2, 84.0, 80.7, and 82.1 %, respectively, and for {sup 18}F-FDG PET/CT were 77.8, 89.7, 87.5, 81.2, and 83.9 %, respectively. There was excellent agreement between results of {sup 13}N-NH{sub 3} PET/CT and {sup 18}F-FDG PET/CT (k = 0.964; P < 0.001). The performances of {sup 13}N-NH{sub 3} PET/CT and {sup 18}F-FDG PET/CT were not significantly different between high-grade and low-grade glioma (P = 1.000). A strong positive correlation was noted between the uptake ratios derived on the two modalities (ρ = 0.866, P < 0.001 for T/W; ρ = 0.918, P < 0.001 for T/G). A combination of {sup 13}N-NH{sub 3} PET/CT and {sup 18}F-FDG PET/CT demonstrates that perfusion and metabolism are coupled in recurrent gliomas. These tracers target two different but interrelated aspects of the same pathologic process and can be used as surrogates for each other. (orig.)

  19. Clinical Reliability and Validity of Prospective Memory Test for Schizophrenics%前瞻性记忆测验对精神分裂症患者的临床信度和效度

    Institute of Scientific and Technical Information of China (English)

    王林平; 谢孟杰; 邹义壮; 郜肖肖; 张勇; 温玉杰; 郑文静

    2013-01-01

    Objective To develop Prospective Memory Test and explore its reliability and validity in normal and schizophrenic popula-tion. Methods According to the structure of prospective memory, Prospective Memory Test was developed based on the previous researches. 40 inpatients with schizophrenia and 30 healthy subjects were assessed with Prospective Memory Test and Wechsler Memory Scale-Fourth Edition, Chinese (WMS-Ⅳ). Results Factor analysis extracted 2 main factors, named time-based prospective memory (TBPM) and event-based prospective memory (EBPM), including 10 items. The average score of Prospective Memory Test was lower in the patients than in the healthy controls by 1~2 standard deviations (P1,累计贡献率46.1%),10个条目的因子载荷均≥0.4。精神分裂症组前瞻性记忆任务平均分比正常对照组低1~2个标准差(P<0.001)。判别分析显示,测验的特异性为93.3%,敏感性为72.5%;与金标准符合率为81.4%。精神分裂症组前瞻性记忆测验总分和分测验评分与WMS-Ⅳ总分均呈正相关(r=0.44~0.53, P<0.001)。条目间Cronbach'sα=0.76,基于时间的前瞻性记忆分测验的Cronbach'sα=0.68;基于事件的前瞻性记忆分测验的Cronbach'sα=0.59。测验的分半信度为0.65(P<0.001)。结论前瞻性记忆测验对精神分裂症患者具有较好的临床信度和效度。

  20. Heart rate at discharge and long-term prognosis following percutaneous coronary intervention in stable and acute coronary syndromes — results from the BASKET PROVE trial

    DEFF Research Database (Denmark)

    Jensen, Magnus Thorsten; Kaiser, Christoph; Sandsten, Karl Erik;

    2013-01-01

    Elevated heart rate (HR) is associated with mortality in a number of heart diseases. We examined the long-term prognostic significance of HR at discharge in a contemporary population of patients with stable angina (SAP), non-ST-segment elevation acute coronary syndromes (NSTE-ACS), and ST......-segment elevation myocardial infarction (STEMI) revascularized with percutaneous coronary intervention (PCI)....

  1. External validation of prognostic models to predict risk of gestational diabetes mellitus in one Dutch cohort: prospective multicentre cohort study.

    NARCIS (Netherlands)

    Lamain-de Ruiter, M.; Kwee, A.; Naaktgeboren, C.A.; Groot, I. de; Evers, I.M.; Groenendaal, F.; Hering, Y.R.; Huisjes, A.J.M.; Kirpestein, C.; Monincx, W.M.; Siljee, J.E.; Zelfde, A. van't; Oirschot, C.M. van; Vankan-Buitelaar, S.A.; Vonk, M.A.A.W.; Wiegers, T.A.; Zwart, J.J.; Franx, A.; Moons, K.G.M.; Koster, M.P.H.

    2016-01-01

    Objective: To perform an external validation and direct comparison of published prognostic models for early prediction of the risk of gestational diabetes mellitus, including predictors applicable in the first trimester of pregnancy. Design: External validation of all published prognostic models in

  2. Adverse events of interferon beta-1a: a prospective multi-centre international ICH-GCP-based CRO-supported external validation study in daily practice.

    NARCIS (Netherlands)

    Jongen, P.J.H.; Sindic, C.; Sanders, E.; Hawkins, S.; Linssen, W.; Munster, E. van; Frequin, S.T.F.M.; Borm, G.F.

    2011-01-01

    BACKGROUND: Due to methodological shortcomings the available post-registration data on the adverse events (AEs) occurring in interferon beta-1a (INFb-1a)-treated patients fail to adequately validate phase III data and only partially inform on safety in daily practice. We assessed AEs in relapsing re

  3. Development and validation of serum bilirubin nomogram to predict the absence of risk for severe hyperbilirubinaemia before discharge: a prospective, multicenter study

    Directory of Open Access Journals (Sweden)

    Romagnoli Costantino

    2012-02-01

    Full Text Available Abstract Background Early discharge of healthy late preterm and full term newborn infants has become common practice because of the current social and economic necessities. Severe jaundice, and even kernicterus, has developed in some term infants discharged early. This study was designed to elaborate a percentile-based hour specific total serum bilirubin (TSB nomogram and to assess its ability to predict the absence of risk for subsequent non physiologic severe hyperbilirubinaemia before discharge. Methods A percentile-based hour-specific nomogram for TSB values was performed using TSB data of 1708 healthy full term neonates. The nomogram's predictive ability was then prospectively assessed in five different first level neonatal units, using a single TSB value determined before discharge. Results The 75 th percentile of hour specific TSB nomogram allows to predict newborn babies without significant hyperbilirubinemia only after the first 72 hours of life. In the first 48 hours of life the observation of false negative results did not permit a safe discharge from the hospital. Conclusion The hour-specific TSB nomogram is able to predict all neonates without risk of non physiologic hyperbilirubinemia only after 48 to 72 hours of life. The combination of TSB determination and risk factors for hyperbilirubinemia could facilitate a safe discharge from the hospital and a targeted intervention and follow-up.

  4. Validation of Two MODIS Aerosols Algorithms with SKYNET and Prospects for Future Climate Satellites Such as the GCOM-C/SGLI

    Directory of Open Access Journals (Sweden)

    Jules R. Dim

    2013-01-01

    Full Text Available Potential improvements of aerosols algorithms for future climate-oriented satellites such as the coming Global Change Observation Mission Climate/Second generation Global Imager (GCOM-C/SGLI are discussed based on a validation study of three years’ (2008–2010 daily aerosols properties, that is, the aerosol optical thickness (AOT and the Ångström exponent (AE retrieved from two MODIS algorithms. The ground-truth data used for this validation study are aerosols measurements from 3 SKYNET ground sites. The results obtained show a good agreement between the ground-truth data AOT and that of one of the satellites’ algorithms, then a systematic overestimation (around 0.2 by the other satellites’ algorithm. The examination of the AE shows a clear underestimation (by around 0.2–0.3 by both satellites’ algorithms. The uncertainties explaining these ground-satellites’ algorithms discrepancies are examined: the cloud contamination affects differently the aerosols properties (AOT and AE of both satellites’ algorithms due to the retrieval scale differences between these algorithms. The deviation of the real part of the refractive index values assumed by the satellites’ algorithms from that of the ground tends to decrease the accuracy of the AOT of both satellites’ algorithms. The asymmetry factor (AF of the ground tends to increase the AE ground-satellites discrepancies as well.

  5. Validation of prospective whole-body bone marrow dosimetry by SPECT/CT multimodality imaging in {sup 131}I-anti-CD20 rituximab radioimmunotherapy of non-Hodgkin's lymphoma

    Energy Technology Data Exchange (ETDEWEB)

    Boucek, Jan A. [Fremantle Hospital, Department of Nuclear Medicine, Fremantle (Australia); Turner, J. Harvey [Fremantle Hospital, Department of Nuclear Medicine, Fremantle (Australia); University of Western Australia, School of Medicine and Pharmacology (Australia)

    2005-04-01

    Radioimmunotherapy (RIT) for relapsed non-Hodgkin's lymphoma is emerging as a promising treatment strategy. Myelosuppression is the dose-limiting toxicity and may be particularly problematic in patients heavily pretreated with chemotherapy. Reliable dosimetry is likely to minimise toxicity and improve treatment efficacy, and the aim of this study was to elucidate the complex problems of dosimetry of RIT by using an integrated SPECT/CT system. As a part of a clinical trial of {sup 131}I-anti-CD20 rituximab RIT of non-Hodgkin's lymphoma, we employed a patient-specific prospective dosimetry method utilising the whole-body effective half-life of antibody and the patient's ideal weight to calculate the administered activity for RIT corresponding to a prescribed radiation absorbed dose of 0.75 Gy to the whole body. A novel technique of quantitation of bone marrow uptake with hybrid SPECT/CT imaging was developed to validate this methodology by using post-RIT extended imaging and data collection. A strong, statistically significant correlation (p=0.001) between whole-body effective half-life of antibody and effective marrow half-life was demonstrated. Furthermore, it was found that bone marrow activity concentration was proportional to administered activity per unit weight, height or body surface area (p<0.001). The results of this study show the proposed whole-body dosimetry method to be valid and clinically applicable for safe, effective RIT. (orig.)

  6. Pregnancy-induced gingivitis and OMICS in dentistry: in silico modeling and in vivo prospective validation of estradiol-modulated inflammatory biomarkers.

    Science.gov (United States)

    Gürsoy, Mervi; Zeidán-Chuliá, Fares; Könönen, Eija; Moreira, José C F; Liukkonen, Joonas; Sorsa, Timo; Gürsoy, Ulvi K

    2014-09-01

    Pregnancy-associated gingivitis is a bacterial-induced inflammatory disease with a remarkably high prevalence ranging from 35% to 100% across studies. Yet little is known about the attendant mechanisms or diagnostic biomarkers that can help predict individual susceptibility for rational personalized medicine. We aimed to define inflammatory proteins in saliva, induced or inhibited by estradiol, as early diagnostic biomarkers or target proteins in relation to pregnancy-associated gingivitis. An in silico gene/protein interaction network model was developed by using the STITCH 3.1 with "experiments" and "databases" as input options and a confidence score of 0.700 (high confidence). Salivary estradiol, interleukin (IL)-1β and -8, myeloperoxidase (MPO), matrix metalloproteinase (MMP)-2, -8, and -9, and tissue inhibitor of matrix metalloproteinase (TIMP)-1 levels from 30 women were measured prospectively three times during pregnancy and twice during postpartum. In silico analysis revealed that estradiol interacts with IL-1β and -8 by an activation link when the "actions view" was consulted. In saliva, estradiol concentrations associated positively with TIMP-1 and negatively with MPO and MMP-8 concentrations. When the gingival bleeding on probing percentage (BOP%) was included in the model as an effect modifier, the only association, a negative one, was found between estradiol and MMP-8. Throughout gestation, estradiol modulates the inflammatory response by inhibiting neutrophilic enzymes, such as MMP-8. The interactions between salivary degradative enzymes and proinflammatory cytokines during pregnancy suggest promising ways to identify candidate biomarkers for pregnancy-associated gingivitis, and for personalized medicine in the field of dentistry. Finally, we call for greater investments in, and action for biomarker research in periodontology and dentistry that have surprisingly lagged behind in personalized medicine compared to other fields, such as cancer research.

  7. Effects of Treatment Intensification on Acute Local Toxicity During Radiotherapy for Head and Neck Cancer: Prospective Observational Study Validating CTCAE, Version 3.0, Scoring System

    International Nuclear Information System (INIS)

    Purpose: To quantify the incidence and severity of acute local toxicity in head and neck cancer patients treated with radiotherapy (RT), with or without chemotherapy (CHT), using the Common Terminology Criteria for Adverse Events, version 3.0 (CTCAE v3.0), scoring system. Methods and Materials: Between 2004 and 2006, 149 patients with head and neck cancer treated with RT at our center were prospectively evaluated for local toxicity during treatment. On a weekly basis, patients were monitored and eight toxicity items were recorded according to the CTCAE v3.0 scoring system. Of the 149 patients, 48 (32%) were treated with RT alone (conventional fractionation), 82 (55%) with concomitant CHT and conventional fractionation RT, and 20 (13%) with accelerated-fractionation RT and CHT. Results: Severe (Grade 3-4) adverse events were recorded in 28% (mucositis), 33% (dysphagia), 40% (pain), and 12% (skin) of patients. Multivariate analysis showed CHT to be the most relevant factor independently predicting for worse toxicity (mucositis, dysphagia, weight loss, salivary changes). In contrast, previous surgery, RT acceleration and older age, female gender, and younger age, respectively, predicted for a worse outcome of mucositis, weight loss, pain, and dermatitis. The T-score method confirmed that conventional RT alone is in the 'low-burden' class (T-score = 0.6) and suggests that concurrent CHT and conventional fractionation RT is in the 'high-burden' class (T-score = 1.15). Combined CHT and accelerated-fractionation RT had the highest T-score at 1.9. Conclusions: The CTCAE v3.0 proved to be a reliable tool to quantify acute toxicity in head and neck cancer patients treated with various treatment intensities. The effect of CHT and RT acceleration on the acute toxicity burden was clinically relevant

  8. Prospective validation of ELF test in comparison with Fibroscan and FibroTest to predict liver fibrosis in Asian subjects with chronic hepatitis B.

    Directory of Open Access Journals (Sweden)

    Beom Kyung Kim

    Full Text Available Liver stiffness measurement (LSM and FibroTest (FT are frequently used as non-invasive alternatives for fibrosis staging to liver biopsy. However, to date, diagnostic performances of Enhanced Liver Fibrosis (ELF test, which consists of hyaluronic acid, aminoterminal propeptide of procollagen type-III, and tissue inhibitor of matrix metalloproteinases-1, have not been compared to those of LSM and FT in Asian chronic hepatitis B (CHB patients.Between June 2010 and November 2011, we prospectively enrolled 170 CHB patients who underwent liver biopsies along with LSM, FT, and ELF. The Batts system was used to assess fibrosis stages.Areas under receiver operating characteristic curves (AUROCs to predict significant fibrosis (F≥2, advanced fibrosis (F≥3, and cirrhosis (F = 4 were 0.901, 0.860, and 0.862 for ELF, respectively; 0.937, 0.956, and 0.963 for LSM; and 0.896, 0.921, and 0.881 for FT. AUROCs to predict F≥2 were similar between each other, whereas LSM and FT had better AUROCs than ELF for predicting F≥3 (both p<0.05, and LSM predicted F4 more accurately than ELF (p<0.05. Optimized cutoffs of ELF to maximize sum of sensitivity and specificity were 8.5, 9.4, and 10.1 for F≥2, F≥3, and F = 4, respectively. Using suggested ELF, LSM and FT cutoffs to diagnose F1, F2, F3, and F4, 91 (53.5%, 117 (68.8%, and 110 (64.7% patients, respectively, were correctly classified according to histological results.ELF demonstrated considerable diagnostic value in fibrosis staging in Asian CHB patients, especially in predicting F≥2. However, LSM consistently provided better performance for predicting F≥3 and F4.

  9. Quantitative single photon emission computed thallium-201 tomography for detection and localization of coronary artery disease: Optimization and prospective validation of a new technique

    Energy Technology Data Exchange (ETDEWEB)

    Maddahi, J.; Van Train, K.; Prigent, F.; Garcia, E.V.; Friedman, J.; Ostrzega, E.; Berman, D. (Cedars-Sinai Medical Center, Los Angeles, CA (USA))

    1989-12-01

    One hundred eight-three men underwent stress-redistribution thallium-201 myocardial perfusion tomography. After evaluation of various preprocessing filters in a phantom study, the Butterworth filter with a frequency cutoff of 0.2 cycles/pixel, order 5 (which provided optimal filter power) was used in the back projection algorithm of the patient studies. All short-axis and apical portions of vertical long-axis images were quantified by dividing each myocardial slice into 60 equal sectors and displaying the maximal count per sector as a linear profile. In a pilot group consisting of 20 normal men (less than 5% likelihood of coronary artery disease) and 25 men with coronary artery disease (greater than or equal to 50% coronary stenosis by angiography), profiles representing the lowest observed value below the mean normal profiles provided the best threshold for defining normal limits. Abnormal portions of the patient profiles were plotted on a two-dimensional polar map. The polar map was divided into 102 sectors, and sectors with a probability of greater than or equal to 80% for disease of each one of the three major coronary arteries were clustered to represent specific coronary artery territories. Receiver operating characteristic curve analysis for defect size showed that the optimal threshold for defining a definite perfusion defect was 12% for the left anterior descending and left circumflex and 8% for the right coronary artery territories. These criteria were prospectively applied to an additional 92 patients with angiographic coronary artery disease, 18 patients with normal coronary arteriograms and 28 patients with less than 5% likelihood of coronary disease. Sensitivity, specificity and normalcy rate for overall detection of coronary disease were 96%, 56% and 86%, respectively.

  10. DUNDRUM-2: Prospective validation of a structured professional judgment instrument assessing priority for admission from the waiting list for a Forensic Mental Health Hospital.

    LENUS (Irish Health Repository)

    Flynn, Grainne

    2011-07-03

    Abstract Background The criteria for deciding who should be admitted first from a waiting list to a forensic secure hospital are not necessarily the same as those for assessing need. Criteria were drafted qualitatively and tested in a prospective \\'real life\\' observational study over a 6-month period. Methods A researcher rated all those presented at the weekly referrals meeting using the DUNDRUM-1 triage security scale and the DUNDRUM-2 triage urgency scale. The key outcome measure was whether or not the individual was admitted. Results Inter-rater reliability and internal consistency for the DUNDRUM-2 were acceptable. The DUNDRUM-1 triage security score and the DUNDRUM-2 triage urgency score correlated r = 0.663. At the time of admission, after a mean of 23.9 (SD35.9) days on the waiting list, those admitted had higher scores on the DUNDRUM-2 triage urgency scale than those not admitted, with no significant difference between locations (remand or sentenced prisoners, less secure hospitals) at the time of admission. Those admitted also had higher DUNDRUM-1 triage security scores. At baseline the receiver operating characteristic area under the curve for a combined score was the best predictor of admission while at the time of admission the DUNDRUM-2 triage urgency score had the largest AUC (0.912, 95% CI 0.838 to 0.986). Conclusions The triage urgency items and scale add predictive power to the decision to admit. This is particularly true in maintaining equitability between those referred from different locations.

  11. Pregnancy-induced gingivitis and OMICS in dentistry: in silico modeling and in vivo prospective validation of estradiol-modulated inflammatory biomarkers.

    Science.gov (United States)

    Gürsoy, Mervi; Zeidán-Chuliá, Fares; Könönen, Eija; Moreira, José C F; Liukkonen, Joonas; Sorsa, Timo; Gürsoy, Ulvi K

    2014-09-01

    Pregnancy-associated gingivitis is a bacterial-induced inflammatory disease with a remarkably high prevalence ranging from 35% to 100% across studies. Yet little is known about the attendant mechanisms or diagnostic biomarkers that can help predict individual susceptibility for rational personalized medicine. We aimed to define inflammatory proteins in saliva, induced or inhibited by estradiol, as early diagnostic biomarkers or target proteins in relation to pregnancy-associated gingivitis. An in silico gene/protein interaction network model was developed by using the STITCH 3.1 with "experiments" and "databases" as input options and a confidence score of 0.700 (high confidence). Salivary estradiol, interleukin (IL)-1β and -8, myeloperoxidase (MPO), matrix metalloproteinase (MMP)-2, -8, and -9, and tissue inhibitor of matrix metalloproteinase (TIMP)-1 levels from 30 women were measured prospectively three times during pregnancy and twice during postpartum. In silico analysis revealed that estradiol interacts with IL-1β and -8 by an activation link when the "actions view" was consulted. In saliva, estradiol concentrations associated positively with TIMP-1 and negatively with MPO and MMP-8 concentrations. When the gingival bleeding on probing percentage (BOP%) was included in the model as an effect modifier, the only association, a negative one, was found between estradiol and MMP-8. Throughout gestation, estradiol modulates the inflammatory response by inhibiting neutrophilic enzymes, such as MMP-8. The interactions between salivary degradative enzymes and proinflammatory cytokines during pregnancy suggest promising ways to identify candidate biomarkers for pregnancy-associated gingivitis, and for personalized medicine in the field of dentistry. Finally, we call for greater investments in, and action for biomarker research in periodontology and dentistry that have surprisingly lagged behind in personalized medicine compared to other fields, such as cancer research

  12. Development and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study

    DEFF Research Database (Denmark)

    Mocroft, Amanda; Lundgren, Jens D; Ross, Michael;

    2015-01-01

    antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice. METHODS...... AND FINDINGS: A total of 17,954 HIV-positive individuals from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study with ≥3 estimated glomerular filtration rate (eGFR) values after 1 January 2004 were included. Baseline was defined as the first eGFR > 60 ml/min/1.73 m2 after 1 January 2004...

  13. Validity of information on atopic disease and other illness in young children reported by parents in a prospective birth cohort study

    DEFF Research Database (Denmark)

    Vissing, Nadja Hawwa; Jensen, Signe Marie; Bisgaard, Hans

    2012-01-01

    to ascertain the quality of information on atopic disease and other health symptoms reported by parental interview in a closely monitored birth cohort study. Possible bias from symptom severity and socioeconomics were sought. METHODS: Copenhagen study on Asthma in Childhood (COPSAC) is a clinical birth cohort...... study of 411 children born of asthmatic mothers from 1999 to 2001. Child health is monitored at six-monthly visits with particular emphasis on atopic symptoms and infections. Data from the first three study years on 260 children was compared with records from their family practitioner as an external......, infectious and skin related illness. Our findings support the validity of parental interviews in longitudinal cohort studies investigating atopic disease and illness in childhood....

  14. Prospective validation of microRNA signatures for detecting pancreatic malignant transformation in endoscopic-ultrasound guided fine-needle aspiration biopsies

    Science.gov (United States)

    Frampton, Adam E.; Krell, Jonathan; Prado, Mireia Mato; Gall, Tamara M.H.; Abbassi-Ghadi, Nima; Del Vecchio Blanco, Giovanna; Funel, Niccola; Giovannetti, Elisa; Castellano, Leandro; Basyouny, Mohamed; Habib, Nagy A.; Kaltsidis, Harry; Vlavianos, Panagiotis; Stebbing, Justin; Jiao, Long R.

    2016-01-01

    Background Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease. Novel biomarkers are required to aid treatment decisions and improve patient outcomes. MicroRNAs (miRNAs) are potentially ideal diagnostic biomarkers, as they are stable molecules, and tumour and tissue specific. Results Logistic regression analysis revealed an endoscopic-ultrasound fine-needle aspiration (EUS-FNA) 2-miRNA classifier (miR-21 + miR-155) capable of distinguishing benign from malignant pancreatic lesions with a sensitivity of 81.5% and a specificity of 85.7% (AUC 0.930). Validation FNA cohorts confirmed both miRNAs were overexpressed in malignant disease, while circulating miRNAs performed poorly. Methods Fifty-five patients with a suspicious pancreatic lesion on cross-sectional imaging were evaluated by EUS-FNA. At echo-endoscopy, the first part of the FNA was sent for cytological assessment and the second part was used for total RNA extraction. Candidate miRNAs were selected after careful review of the literature and expression was quantified by qRT-PCR. Validation was performed on an independent cohort of EUS-FNAs, as well as formalin-fixed paraffin embedded (FFPE) and plasma samples. Conclusions We provide further evidence for using miRNAs as diagnostic biomarkers for pancreatic malignancy. We demonstrate the feasibility of using fresh EUS-FNAs to establish miRNA-based signatures unique to pancreatic malignant transformation and the potential to enhance risk stratification and selection for surgery. PMID:27086919

  15. Seven-day mortality can be predicted in medical patients by blood pressure, age, respiratory rate, loss of independence, and peripheral oxygen saturation (the PARIS score: a prospective cohort study with external validation.

    Directory of Open Access Journals (Sweden)

    Mikkel Brabrand

    Full Text Available Most existing risk stratification systems predicting mortality in emergency departments or admission units are complex in clinical use or have not been validated to a level where use is considered appropriate. We aimed to develop and validate a simple system that predicts seven-day mortality of acutely admitted medical patients using routinely collected variables obtained within the first minutes after arrival.This observational prospective cohort study used three independent cohorts at the medical admission units at a regional teaching hospital and a tertiary university hospital and included all adult (≥ 15 years patients. Multivariable logistic regression analysis was used to identify the clinical variables that best predicted the endpoint. From this, we developed a simplified model that can be calculated without specialized tools or loss of predictive ability. The outcome was defined as seven-day all-cause mortality. 76 patients (2.5% met the endpoint in the development cohort, 57 (2.0% in the first validation cohort, and 111 (4.3% in the second. Systolic blood Pressure, Age, Respiratory rate, loss of Independence, and peripheral oxygen Saturation were associated with the endpoint (full model. Based on this, we developed a simple score (range 0-5, ie, the PARIS score, by dichotomizing the variables. The ability to identify patients at increased risk (discriminatory power and calibration was excellent for all three cohorts using both models. For patients with a PARIS score ≥ 3, sensitivity was 62.5-74.0%, specificity 85.9-91.1%, positive predictive value 11.2-17.5%, and negative predictive value 98.3-99.3%. Patients with a score ≤ 1 had a low mortality (≤ 1%; with 2, intermediate mortality (2-5%; and ≥ 3, high mortality (≥ 10%.Seven-day mortality can be predicted upon admission with high sensitivity and specificity and excellent negative predictive values.

  16. Harmonizing SUVs in multicentre trials when using different generation PET systems: prospective validation in non-small cell lung cancer patients

    Energy Technology Data Exchange (ETDEWEB)

    Lasnon, Charline; Quak, Elske [Francois Baclesse Cancer Centre, Nuclear Medicine Department, Caen (France); Desmonts, Cedric [Caen University Hospital, Nuclear Medicine Department, Caen (France); Gervais, Radj; Do, Pascal; Dubos-Arvis, Catherine [Francois Baclesse Cancer Centre, Thoracic Oncology, Caen (France); Aide, Nicolas [Francois Baclesse Cancer Centre, Nuclear Medicine Department, Caen (France); Centre Francois Baclesse, Service de Medecine Nucleaire, Caen cedex 5 (France)

    2013-07-15

    We prospectively evaluated whether a strategy using point spread function (PSF) reconstruction for both diagnostic and quantitative analysis in non-small cell lung cancer (NSCLC) patients meets the European Association of Nuclear Medicine (EANM) guidelines for harmonization of quantitative values. The NEMA NU-2 phantom was used to determine the optimal filter to apply to PSF-reconstructed images in order to obtain recovery coefficients (RCs) fulfilling the EANM guidelines for tumour positron emission tomography (PET) imaging (PSF{sub EANM}). PET data of 52 consecutive NSCLC patients were reconstructed with unfiltered PSF reconstruction (PSF{sub allpass}), PSF{sub EANM} and with a conventional ordered subset expectation maximization (OSEM) algorithm known to meet EANM guidelines. To mimic a situation in which a patient would undergo pre- and post-therapy PET scans on different generation PET systems, standardized uptake values (SUVs) for OSEM reconstruction were compared to SUVs for PSF{sub EANM} and PSF{sub allpass} reconstruction. Overall, in 195 lesions, Bland-Altman analysis demonstrated that the mean ratio between PSF{sub EANM} and OSEM data was 1.03 [95 % confidence interval (CI) 0.94-1.12] and 1.02 (95 % CI 0.90-1.14) for SUV{sub max} and SUV{sub mean}, respectively. No difference was noticed when analysing lesions based on their size and location or on patient body habitus and image noise. Ten patients (84 lesions) underwent two PET scans for response monitoring. Using the European Organization for Research and Treatment of Cancer (EORTC) criteria, there was an almost perfect agreement between OSEM{sub PET1}/OSEM{sub PET2} (current standard) and OSEM{sub PET1}/PSF{sub EANM-PET2} or PSF{sub EANM-PET1}/OSEM{sub PET2} with kappa values of 0.95 (95 % CI 0.91-1.00) and 0.99 (95 % CI 0.96-1.00), respectively. The use of PSF{sub allpass} either for pre- or post-treatment (i.e. OSEM{sub PET1}/PSF{sub allpass-PET2} or PSF{sub allpass-PET1}/OSEM{sub PET2}) showed

  17. The diagnosis of urinary tract infections in young children (DUTY: protocol for a diagnostic and prospective observational study to derive and validate a clinical algorithm for the diagnosis of UTI in children presenting to primary care with an acute illness

    Directory of Open Access Journals (Sweden)

    Downing Harriet

    2012-07-01

    Full Text Available Abstract Background Urinary tract infection (UTI is common in children, and may cause serious illness and recurrent symptoms. However, obtaining a urine sample from young children in primary care is challenging and not feasible for large numbers. Evidence regarding the predictive value of symptoms, signs and urinalysis for UTI in young children is urgently needed to help primary care clinicians better identify children who should be investigated for UTI. This paper describes the protocol for the Diagnosis of Urinary Tract infection in Young children (DUTY study. The overall study aim is to derive and validate a cost-effective clinical algorithm for the diagnosis of UTI in children presenting to primary care acutely unwell. Methods/design DUTY is a multicentre, diagnostic and prospective observational study aiming to recruit at least 7,000 children aged before their fifth birthday, being assessed in primary care for any acute, non-traumatic, illness of ≤ 28 days duration. Urine samples will be obtained from eligible consented children, and data collected on medical history and presenting symptoms and signs. Urine samples will be dipstick tested in general practice and sent for microbiological analysis. All children with culture positive urines and a random sample of children with urine culture results in other, non-positive categories will be followed up to record symptom duration and healthcare resource use. A diagnostic algorithm will be constructed and validated and an economic evaluation conducted. The primary outcome will be a validated diagnostic algorithm using a reference standard of a pure/predominant growth of at least >103, but usually >105 CFU/mL of one, but no more than two uropathogens. We will use logistic regression to identify the clinical predictors (i.e. demographic, medical history, presenting signs and symptoms and urine dipstick analysis results most strongly associated with a positive urine culture result. We will

  18. Biodiversity Prospecting.

    Science.gov (United States)

    Sittenfeld, Ana; Lovejoy, Annie

    1994-01-01

    Examines the use of biodiversity prospecting as a method for tropical countries to value biodiversity and contribute to conservation upkeep costs. Discusses the first agreement between a public interest organization and pharmaceutical company for the extraction of plant and animal materials in Costa Rica. (LZ)

  19. The Diagnosis of Urinary Tract infection in Young children (DUTY): a diagnostic prospective observational study to derive and validate a clinical algorithm for the diagnosis of urinary tract infection in children presenting to primary care with an acute illness.

    Science.gov (United States)

    Hay, Alastair D; Birnie, Kate; Busby, John; Delaney, Brendan; Downing, Harriet; Dudley, Jan; Durbaba, Stevo; Fletcher, Margaret; Harman, Kim; Hollingworth, William; Hood, Kerenza; Howe, Robin; Lawton, Michael; Lisles, Catherine; Little, Paul; MacGowan, Alasdair; O'Brien, Kathryn; Pickles, Timothy; Rumsby, Kate; Sterne, Jonathan Ac; Thomas-Jones, Emma; van der Voort, Judith; Waldron, Cherry-Ann; Whiting, Penny; Wootton, Mandy; Butler, Christopher C

    2016-01-01

    BACKGROUND It is not clear which young children presenting acutely unwell to primary care should be investigated for urinary tract infection (UTI) and whether or not dipstick testing should be used to inform antibiotic treatment. OBJECTIVES To develop algorithms to accurately identify pre-school children in whom urine should be obtained; assess whether or not dipstick urinalysis provides additional diagnostic information; and model algorithm cost-effectiveness. DESIGN Multicentre, prospective diagnostic cohort study. SETTING AND PARTICIPANTS Children < 5 years old presenting to primary care with an acute illness and/or new urinary symptoms. METHODS One hundred and seven clinical characteristics (index tests) were recorded from the child's past medical history, symptoms, physical examination signs and urine dipstick test. Prior to dipstick results clinician opinion of UTI likelihood ('clinical diagnosis') and urine sampling and treatment intentions ('clinical judgement') were recorded. All index tests were measured blind to the reference standard, defined as a pure or predominant uropathogen cultured at ≥ 10(5) colony-forming units (CFU)/ml in a single research laboratory. Urine was collected by clean catch (preferred) or nappy pad. Index tests were sequentially evaluated in two groups, stratified by urine collection method: parent-reported symptoms with clinician-reported signs, and urine dipstick results. Diagnostic accuracy was quantified using area under receiver operating characteristic curve (AUROC) with 95% confidence interval (CI) and bootstrap-validated AUROC, and compared with the 'clinician diagnosis' AUROC. Decision-analytic models were used to identify optimal urine sampling strategy compared with 'clinical judgement'. RESULTS A total of 7163 children were recruited, of whom 50% were female and 49% were < 2 years old. Culture results were available for 5017 (70%); 2740 children provided clean-catch samples, 94% of whom were ≥ 2 years old

  20. Prospective validation of two models for ultrasonographic diagnosis of cirrhosis Validación prospectiva de dos modelos de diagnóstico de cirrosis hepática mediante ultrasonografía

    Directory of Open Access Journals (Sweden)

    Manuel Alberto Macías-Rodríguez

    2011-05-01

    Full Text Available Objective: to perform a prospective validation and comparative analysis of two ultrasonographic diagnostic scores of cirrhosis in patients with silent liver disease. Design: cross-sectional study, prospective and blind. ROC curves evaluated the diagnostic utility of: a Bologna score (BS: assessment of liver surface nodularity and portal flow velocity, and b Cadiz score (CS: assessment of liver echostructure, portal vein caliber and spleen area. Liver biopsy was considered the gold standard for the diagnosis of cirrhosis. Patients: one hundred and thirteen patients, 76 men and 37 women, mean age 44 years old (range 18-73 years referred for evaluation of chronic liver disease without clinical or biochemical evidence of advanced disease (absence of jaundice, ascites, encephalopathy, malnutrition or coagulopathy. Results: cirrhosis was diagnosed in 25 patients (22.1%. BS: sensitivity 84%, specificity 79.5%, area under the ROC curve 86.7%. CS: sensitivity 84%, specificity 89.8%, area under the ROC curve 92.4%. Portal vein was not displayed in 7 patients (6% and portal flow velocity was not recorded in 13 (11.5%. These results agree with those obtained in the original articles developing both scores. There were no statistically significant differences between the two scores. Specificity reached 97% with joint use of both models, but sensitivity decreased to 72%. Conclusions: presence or absence of cirrhosis in patients with silent liver disease can be established by Doppler ultrasound with high diagnostic accuracy. The joint use of both scores has high diagnostic specificity. Both diagnostic models are highly reproducible.Objetivo: realizar una validación prospectiva y un análisis comparativo de dos escalas de diagnóstico ecográfico de cirrosis en pacientes con enfermedad hepática silente. Diseño experimental: estudio transversal, prospectivo y ciego. Mediante curvas ROC se evaluó la utilidad diagnóstica de: a escala de Bolonia (EB: valoraci

  1. Clouded Prospects

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ As the European debt crisis deepens,the word economy has yet to find its footing despite signs of growth and renewed confidence.While the developed world faces the challenge of fiscal indebtedness,many developing countries are feeling the pinch of capital inflows and trade downturn.Global Economic Prospects 2010,the latest report by the World Bank,discussed these issues.Edited excerpts follow:

  2. Uranium project. Geochemistry prospection

    International Nuclear Information System (INIS)

    Geochemistry studies the distribution of the chemicals elements in the terrestrial crust and its ways to migrate. The terminology used in this report is the following one: 1) Principles of the prospection geochemistry 2) Stages of the prospection geochemistry 3)utility of the prospection geochemistry 4) geochemistry of uranium 5) procedures used within the framework of uranium project 6) Average available 7) Selection of the zones of prospection geochemistry 8) Stages of the prospection, Sample preparation and analisis 9) Presentation of the results

  3. The Pediatric Rheumatology International Trials Organization/American College of Rheumatology provisional criteria for the evaluation of response to therapy in juvenile systemic lupus erythematosus: prospective validation of the definition of improvement

    DEFF Research Database (Denmark)

    Ruperto, N; Ravelli, A; Oliviera, S;

    2006-01-01

    OBJECTIVE: To use the Pediatric Rheumatology International Trials Organization (PRINTO) core set of outcome measures to develop a validated definition of improvement for the evaluation of response to therapy in juvenile systemic lupus erythematosus (SLE). METHODS: Thirty-seven experienced pediatric...... proposes a valid and reproducible definition of improvement that reflects well the consensus rating of experienced clinicians and that incorporates clinically meaningful change in core set measures in a composite end point for the evaluation of global response to therapy in patients with juvenile SLE....... The definition is now proposed for use in juvenile SLE clinical trials and may help physicians to decide whether a child with SLE responded adequately to therapy....

  4. Validation of the revised international prognostic scoring system (IPSS-R) in patients with lower-risk myelodysplastic syndromes: a report from the prospective European LeukaemiaNet MDS (EUMDS) registry

    NARCIS (Netherlands)

    Swart, L. de; Smith, A.; Johnston, T.W.; Haase, D.; Droste, J.; Fenaux, P.; Symeonidis, A.; Sanz, G.; Hellstrom-Lindberg, E.; Cermak, J.; Germing, U.; Stauder, R.; Georgescu, O.; MacKenzie, M.; Malcovati, L.; Holm, M.S.; Almeida, A.M.; Madry, K.; Slama, B.; Guerci-Bresler, A.; Sanhes, L.; Beyne-Rauzy, O.; Luno, E.; Bowen, D.; Witte, T.J. de

    2015-01-01

    Baseline characteristics, disease-management and outcome of 1000 lower-risk myelodysplastic syndrome (MDS) patients within the European LeukaemiaNet MDS (EUMDS) Registry are described in conjunction with the validation of the revised International Prognostic Scoring System (IPSS-R). The EUMDS regist

  5. Prospective teachers information and communication technology metaphors

    Directory of Open Access Journals (Sweden)

    Ömür Akdemir

    2015-04-01

    Full Text Available Determination of the perceptions of the prospective teachers for the Information and Communications Technology (ICT terms have a remarkable potential to provide input for technology integration plans and ICT trainings. Within this context, the purpose of this study is to discover the metaphors constructed by prospective teachers for the ICT terms. Data were gathered from 180 prospective teachers through survey. 977 valid metaphors constructed by the participants were grouped into conceptual categories for the six ICT terms. The most common conceptual categories are “developing and changing” for technology, “making life easy” for computers and search engines, “limitless and endless” for the Internet, “means of communication” for social networks, and “addictive items” for video games. Future research should concentrate on investigating the match and mismatches between intended use of the ICT tools and the perception of the prospective teachers.

  6. Validity of Short and Long Self-Administered Food Frequency Questionnaires in Ranking Dietary Intake in Middle-Aged and Elderly Japanese in the Japan Public Health Center-Based Prospective Study for the Next Generation (JPHC-NEXT) Protocol Area

    Science.gov (United States)

    Yokoyama, Yuta; Takachi, Ribeka; Ishihara, Junko; Ishii, Yuri; Sasazuki, Shizuka; Sawada, Norie; Shinozawa, Yurie; Tanaka, Junta; Kato, Erika; Kitamura, Kaori; Nakamura, Kazutoshi; Tsugane, Shoichiro

    2016-01-01

    Background Longitudinal epidemiological studies require both the periodic update of intake information via repeated dietary survey and the minimization of subject burden in responding to questionnaires. We developed a 66-item Food Frequency Questionnaire (short-FFQ) for the Japan Public Health Center-based prospective Study for the Next Generation (JPHC-NEXT) follow-up survey using major foods from the FFQ developed for the original JPHC Study. For the JPHC-NEXT baseline survey, we used a larger 172-item FFQ (long-FFQ), which was also derived from the JPHC-FFQ. We compared the validity of ranking individuals by levels of dietary consumption by these FFQs among residents of selected JPHC-NEXT study areas. Methods From 2012 to 2013, 240 men and women aged 40–74 years from five areas in the JPHC-NEXT protocol were asked to respond to the long-FFQ and provide 12-day weighed food records (WFR) as reference; 228 also completed the short-FFQ. Spearman’s correlation coefficients (CCs) between estimates from the FFQs and WFR were calculated and corrected for intra-individual variation of the WFR. Results Median CC values for energy and 53 nutrients for the short-FFQ for men and women were 0.46 and 0.44, respectively. Respective values for the long-FFQ were 0.50 and 0.43. Compared with the long-FFQ, cross-classification into exact plus adjacent quintiles with the short-FFQ ranged from 68% to 91% in men and 58% to 85% in women. Conclusions Similar to the long-FFQ, the short-FFQ provided reasonably valid measures for ranking middle-aged and elderly Japanese for many nutrients and food groups. The short-FFQ can be used in follow-up surveys in prospective cohort studies aimed at updating diet rank information. PMID:27064130

  7. 炎症性肠病ICF评定量表信效度的初步分析%Prospective validation study of the international classification of functioning, disability and health score in inflammatory bowel disease

    Institute of Scientific and Technical Information of China (English)

    张倩; 王康磊; 袁正; 张苏闽

    2015-01-01

    [目的]初步分析中文版炎症性肠病(IBD)ICF核心分类量表(IBD‐DI)在IBD患者中的信度及效度,为临床应用提供客观依据。[方法]对IBD患者进行IBD‐DI及IBD问卷(IBDQ )调查及评价,并进行相关分析。[结果]根据112份调查表结果显示:IBD‐DI中各项、各亚量表及总评分结果相关系数均>0.75,Cronbach’s alpha值均>0.7。IBD‐DI与IBDQ显著性相关(r=0.613~0.849,P=0.000)。[结论]中文版IBD‐DI在IBD患者中有较好的信度及效度,可用于IBD患者的评估。%Objective]To evaluate the reliability and validity of IBD (inflammatory bowel disease) disa‐bility index(IBD‐DI)in IBD patients .[Methods]Based on the questionnaires of IBD disease index and in‐flammatory bowel disease questionnaire (IBDQ ) ,the database was established with data analysis in SPSS 18 .0 .[Results]The totals of 112 consecutive subjects were recruited .Intraclass correlation was higher than 0 .75 and Cronbach’s alpha of internal consistency was higher than 0 .7 .IBD‐DI correlated with IBDQ (r=0 .613-0 .849 ,P=0 .000) .[Conclusion]The IBD‐DI is a valid tool measuring disability in IBD (both UC and CD)with good reliability and validity .

  8. The reliability and validity of the Chinese version of the Cambridge Prospective Memory Test with Chinese brain injured patients%中文版剑桥前瞻性记忆测试量表的信度和标准效度研究

    Institute of Scientific and Technical Information of China (English)

    罗子芮; 窦祖林; 郑金利; 陈颖蓓

    2009-01-01

    目的 探讨中文版剑桥前瞻性记忆测试(C-CAMPROMPT)用于评估中国脑损伤患者的各种信度和标准效度.方法 按程序将英文版剑桥前瞻性记忆测试(CAMPROMPT)翻译成中文.30例"正常人"作为信度组和39例临床观察发现存在记忆功能障碍的脑损伤患者作为效度组入选本研究.采用相关分析、Cronbach α系数法分析量表的重测信度、测试者间信度、复本信度、同质性信度及标准效度.结果 信度测试的相关系数和Cronbach α系数为0.697~0.951.效度分析结果显示,C-CAMPROMPT总分和基于事件任务得分与Rivermead行为记忆测试(RBMT)各领域得分呈正相关,基于时间任务与中文版Stroop字-颜色测试(C-SCWT)回溯性记忆任务得分呈负相关.结论 C-CAMPROMPT具有良好的信度和效度,可用于临床评估中国脑损伤患者的前瞻性记忆功能.%Objective To evaluate the reliability and criteria validity of the Chinese Cambridge Prospective Memory Test (C-CAMPROMPT) for testing Chinese patients with acquired brain injury. Methods The CAMPROMPT was translated into Chinese. The translated Version was then used with 30 'normal persons' and 39 with acquired brain injury and memory problems. Correlation analysis and Cronbach's a were used to evaluate reliability and criteria validity of the C-CAMPROMPT. Results Correlation and Cronbach's a were in the range 0.697 to 0.951.The total and event-based scores were positively corrlated with all three field Chinese Version of Rivermead Behavior Memory Test scores. Time-based C-CAMPROMPT scores,however,were negatively correlated with Chinese Version of the Stroop Word-Color Test results. Conclusion The reliability and validity of the C-CAMPROMPT were high enough to be used to test the prospective memory of acquired brain injury patients in the clinic.

  9. Predictive Validity of the American College of Cardiology/American Heart Association Pooled Cohort Equations in Predicting All-Cause and Cardiovascular Disease-Specific Mortality in a National Prospective Cohort Study of Adults in the United States.

    Science.gov (United States)

    Loprinzi, Paul D; Addoh, Ovuokerie

    2016-06-01

    The predictive validity of the Pooled Cohort risk (PCR) equations for cardiovascular disease (CVD)-specific and all-cause mortality among a national sample of US adults has yet to be evaluated, which was this study's purpose. Data from the 1999-2010 National Health and Nutrition Examination Survey were used, with participants followed up through December 31, 2011, to ascertain mortality status via the National Death Index probabilistic algorithm. The analyzed sample included 11,171 CVD-free adults (40-79 years of age). The 10-year risk of a first atherosclerotic cardiovascular disease (ASCVD) event was determined from the PCR equations. For the entire sample encompassing 849,202 person-months, we found an incidence rate of 1.00 (95% CI, 0.93-1.07) all-cause deaths per 1000 person-months and an incidence rate of 0.15 (95% CI, 0.12-0.17) CVD-specific deaths per 1000 person-months. The unweighted median follow-up duration was 72 months. For nearly all analyses (unadjusted and adjusted models with ASCVD expressed as a continuous variable as well as dichotomized at 7.5% and 20%), the ASCVD risk score was significantly associated with all-cause and CVD-specific mortality (P<.05). In the adjusted model, the increased all-cause mortality risk ranged from 47% to 77% based on an ASCVD risk of 20% or higher and 7.5% or higher, respectively. Those with an ASCVD score of 7.5% or higher had a 3-fold increased risk of CVD-specific mortality. The 10-year predicted risk of a first ASCVD event via the PCR equations was associated with all-cause and CVD-specific mortality among those free of CVD at baseline. In this American adult sample, the PCR equations provide evidence of predictive validity. PMID:27180122

  10. CANDU market prospects

    International Nuclear Information System (INIS)

    This 1994 survey of prospective markets for CANDU reactors discusses prospects in Turkey, Thailand, the Philippines, Korea, Indonesia, China and Egypt, and other opportunities, such as in fuel cycles and nuclear safety. It was concluded that foreign partners would be needed to help with financing

  11. SANSMIC Validation.

    Energy Technology Data Exchange (ETDEWEB)

    Weber, Paula D.; Rudeen, David Keith; Lord, David L.

    2014-08-01

    SANSMIC is solution mining software that was developed and utilized by SNL in its role as geotechnical advisor to the US DOE SPR for planning purposes. Three SANSMIC leach modes - withdrawal, direct, and reverse leach - have been revalidated with multiple test cases for each mode. The withdrawal mode was validated using high quality data from recent leach activity while the direct and reverse modes utilized data from historical cavern completion reports. Withdrawal results compared very well with observed data, including the location and size of shelves due to string breaks with relative leached volume differences ranging from 6 - 10% and relative radius differences from 1.5 - 3%. Profile comparisons for the direct mode were very good with relative leached volume differences ranging from 6 - 12% and relative radius differences from 5 - 7%. First, second, and third reverse configurations were simulated in order to validate SANSMIC over a range of relative hanging string and OBI locations. The first-reverse was simulated reasonably well with relative leached volume differences ranging from 1 - 9% and relative radius differences from 5 - 12%. The second-reverse mode showed the largest discrepancies in leach profile. Leached volume differences ranged from 8 - 12% and relative radius differences from 1 - 10%. In the third-reverse, relative leached volume differences ranged from 10 - 13% and relative radius differences were %7E4 %. Comparisons to historical reports were quite good, indicating that SANSMIC is essentially the same as documented and validated in the early 1980's.

  12. The PROSPECT Physics Program

    CERN Document Server

    Ashenfelter, J; Band, H R; Barclay, G; Bass, C D; Berish, D; Bowden, N S; Bowes, A; Bryan, C D; Brodsky, J P; Cherwinka, J J; Chu, R; Classen, T; Commeford, K; Davee, D; Dean, D; Deichert, G; Diwan, M V; Dolinski, M J; Dolph, J; Gaison, J K; Galindo-Uribarri, A; Gilje, K; Glenn, A; Goddard, B W; Green, M; Han, K; Hans, S; Heeger, K M; Heffron, B; Jaffe, D E; Jones, D; Langford, T J; Littlejohn, B R; Caicedo, D A Martinez; McKeown, R D; Mendenhall, M P; Mueller, P; Mumm, H P; Napolitano, J; Neilson, R; Norcini, D; Pushin, D; Qian, X; Romero, E; Rosero, R; Seilhan, B S; Sharma, R; Sheets, S; Surukuchi, P T; Varner, R L; Viren, B; Wang, W; White, B; White, C; Wilhelmi, J; Williams, C; Wise, T; Yao, H; Yeh, M; Yen, Y -R; Zangakis, G; Zhang, C; Zhang, X

    2015-01-01

    The Precision Reactor Oscillation and Spectrum Experiment, PROSPECT, is designed to make a precise measurement of the antineutrino spectrum from a highly-enriched uranium reactor and probe eV-scale sterile neutrinos by searching for neutrino oscillations over meter-long distances. PROSPECT is conceived as a 2-phase experiment utilizing segmented $^6$Li-doped liquid scintillator detectors for both efficient detection of reactor antineutrinos through the inverse beta decay reaction and excellent background discrimination. PROSPECT Phase I consists of a movable 3-ton antineutrino detector at distances of 7 - 12 m from the reactor core. It will probe the best-fit point of the $\

  13. Prospective ergonomics: origin, goal, and prospects.

    Science.gov (United States)

    Robert, Jean-Marc; Brangier, Eric

    2012-01-01

    So far ergonomics has been concerned with two categories of activities: correction and design. We propose to add a third category: prospection, and by so doing, we introduce a new series of activities that opens up the future of ergonomics. Corrective ergonomics relates to the past and comes with a demand and a client. It is turned towards the correction of existing situations and aims to reduce or eliminate problems. Here, after delimiting and defining the problem, the challenge is to find the best solution. Ergonomics for design relates to the present and also comes with a demand and a client. It is turned towards the design of new artefacts that have already been identified by a client, and that will allow users to do some activity and attain their goals. Here, after defining the scope of the project and the functional requirements, the challenge is to do the best design. Finally, prospective ergonomics relates to the future and does not come with a demand and a client. It is turned towards the creation of future things that have not been identified yet. Here the challenge is to detect existing user needs or anticipate future ones, and imagine solutions. These three categories of activities overlap and are not exclusive of each other. In this paper we define prospective ergonomics and compare it with corrective ergonomics and ergonomics for design. We describe its origin, goal, and prospects, we analyze its impacts on education and practice, and we emphasize the need of new collaboration between ergonomics and other disciplines.

  14. Validated treatments and therapeutics prospectives regarding pharmacological products for sarcopenia.

    Science.gov (United States)

    Onder, G; Della Vedova, C; Landi, F

    2009-10-01

    Loss of physical function in older adults may be, at least in part, explained by sarcopenia, a phenomenon characterized by a reduction in number and size of muscle fibres and by increase in interstitial fat and connective tissue. Lifestyle intervention (i.e. physical activity and nutrition) have shown to impact on sarcopenia. However, several drugs were suggested, with various levels of scientific evidence, to have an impact on muscle outcomes. In this study we reviewed the effect of six classes of drugs on sarcopenia and muscular outcomes in older adults. We decided to focus our review on two commonly drugs which have recently showed promising effects on muscular outcomes in older adults (ACE inhibitors and statins) and on four drugs whose effect on skeletal muscle was already largely studied (creatine, Growth Hormone, testosterone, estrogens and tibolone). PMID:19657562

  15. 中文版剑桥前瞻性记忆测试量表计算机测量用于慢性精神分裂症患者的信效度%Reliability and Validity of Computerized Chinese Version of Cambridge Prospective Memory Test in Chronic Schizophrenia

    Institute of Scientific and Technical Information of China (English)

    谢孟杰; 邹义壮; 王志仁; 陈楠; 张勇; 郜肖肖; 郑文静

    2014-01-01

    目的:探讨中文版剑桥前瞻性记忆测试量表(C-CAMPROMPT)计算机测量用于慢性精神分裂症患者前瞻性记忆(PM)功能评估的临床信效度。方法选取年龄、性别、受教育年限相匹配的慢性精神分裂症患者(病例组)以及健康对照(对照组)各50例。以C-CAMPROMPT计算机测量评估PM功能;以韦氏成人记忆量表第四版中文版(WMS-Ⅳ)评估逻辑记忆(LM)及视觉记忆(VR);以威斯康星卡片分类测验(WCST)评估执行功能;以言语流畅性测验(CFT)评估处理速度;进行C-CAMPROMPT的临床信效度分析。结果该量表的重测信度和分半信度(Pearson相关系数)分别为0.981和0.627(均P<0.001),内部一致性信度(Cronbachα系数)为0.742。病例组PM总分及各个因子、条目得分均低于对照组(均P<0.05)。病例组PM与LM、VR、WCST-CC、CFT正相关(r=0.34~0.89, P<0.05)。判别分析显示量表的灵敏度为86%,特异度为92%,符合率为89%。探索性因子分析将量表的所有条目聚为2个因子(累计贡献率61.46%)。结论 C-CAMPROMPT计算机测量在慢性精神分裂症患者PM功能评估中具有较好的临床信效度,是一个敏感性较高、适用性较强且稳定的工具。%Objective To explore the reliability and validity of the computerized Chinese version of Cambridge Prospective Memory Test (C-CAMPROMPT) for assessment of prospective memory (PM) in chronic schizophrenia patients. Methods 50 patients and 50 healthy controls formed the study sample. PM performance was measured with computerized C-CAMPROMPT, while the Wechsler Adult Memory Scale-Forth Edition (WMS-IV), Wisconsin Card Sorting Test (WCST) and Category Fluency Test (CFT) were administered to assess logical memory (LM), visual representation (VR), executive function and processing speed. Results The test-retest reliability (0.981, P<0.001), split half reliability (0.627, P<0.001) and internal consistency reliability (0.742) of C-CAMPROMPT were

  16. Video Games and Youth Violence: A Prospective Analysis in Adolescents

    Science.gov (United States)

    Ferguson, Christopher J.

    2011-01-01

    The potential influence of violent video games on youth violence remains an issue of concern for psychologists, policymakers and the general public. Although several prospective studies of video game violence effects have been conducted, none have employed well validated measures of youth violence, nor considered video game violence effects in…

  17. Prospects of nuclear energy

    International Nuclear Information System (INIS)

    A broad overviews presented on the future prospects and conditions of nuclear power. Several graphs and diagrams are shown on energy consumption, energy demand, energy sources, pollution by power plants, mineral fuel inventories, fissionable material inventories, renewable energy sources. The conditions of future utilization of nuclear power and nuclear power plants are discussed. (R.P.)

  18. Prospective memory: A comparative perspective

    OpenAIRE

    Crystal, Jonathon D.; Wilson, A. George

    2014-01-01

    Prospective memory consists of forming a representation of a future action, temporarily storing that representation in memory, and retrieving it at a future time point. Here we review the recent development of animal models of prospective memory. We review experiments using rats that focus on the development of time-based and event-based prospective memory. Next, we review a number of prospective-memory approaches that have been used with a variety of non-human primates. Finally, we review se...

  19. Prospective memory research: why is it relevant?

    OpenAIRE

    Kliegel, M; Martin, Mike

    2003-01-01

    Points out that there are at least three reasons why research in prospective memory is highly relevant. Relevance of prospective memory for everyday life; Clinical relevance of prospective memory; Theoretical relevance of prospective memory.

  20. Radimetric autotransported prospecting survey

    International Nuclear Information System (INIS)

    A procedure of prospection of minerals (''carborne''). It is characterized to be rapid and low costly if a sufficiently dense highway network is available or if transit with a vehicle across the fields is possible. Instruments, methods and results that may be obtained are given. The detector, a scintillation counter, is mounted on the top of an appropiate car registering continuously the measured values. Subsequently data are put on cartography, obtaining thus the values of iso-radiactivity which determine the values of ''background'' and the favorable zones for pursuing prospection work by other methods. The application of the method to the zone of the Chihuidos, province of Neuquen, is described in details and the obtained conclusions are given. (author)

  1. a prospective comparative study

    OpenAIRE

    Jäckel, Tanja

    2011-01-01

    Objective: To examine effectiveness and safety of homoeopathic vs. conventional treatment for children with atopic eczema in usual care. In a prospective multicentre comparative observational non-randomized study 135 patients (1-14 years old, homoeopathy n=48 vs. conventional n=87) with moderate atopic eczema were included. Treatment was left to the physicians´preferences in both groups. The primary endpoint was the SCORAD (SCOring Atopic Dermatitis) after 6 months. Secondary outcom...

  2. Bright Economic Prospects

    Institute of Scientific and Technical Information of China (English)

    Zhang Minqiu

    2004-01-01

    @@ India is expected to register an 8.2% growth rate for the 2003-04 fiscal year. The overall economic situation this year has been satisfactory despite the scaled down 6-6.5% growth rate for the new fiscal year due to oil price hikes, reduced monsoon volume and some 7% inflation. Judging from the following factors, bright prospects are in store for the country down the road.

  3. Principles of Proper Validation

    DEFF Research Database (Denmark)

    Esbensen, Kim; Geladi, Paul

    2010-01-01

    of proper validation objectives implies that there is one valid paradigm only: test set validation. (iii) Contrary to much contemporary chemometric practices (and validation myths), cross-validation is shown to be unjustified in the form of monolithic application of a one-for-all procedure (segmented cross-validation......) on all data sets. Within its own design and scope, cross-validation is in reality a sub-optimal simulation of test set validation, crippled by a critical sampling variance omission, as it manifestly is based on one data set only (training data set). Other re-sampling validation methods are shown...... into all variance generating factors, especially the so-called incorrect sampling errors, which, if not properly eliminated, are responsible for a fatal inconstant sampling bias, for which no statistical correction is possible. In the light of TOS it is shown how a second data set (test set, validation set...

  4. Prospective memory in the rat

    OpenAIRE

    Wilson, A. George; Crystal, Jonathon D.

    2011-01-01

    The content of prospective memory is comprised of representations of an action to perform in the future. When people form prospective memories, they temporarily put the memory representation in an inactive state while engaging in other activities, and then activate the representation in the future. Ultimately, successful activation of the memory representation yields an action at an appropriate, but temporally distant, time. A hallmark of prospective memory is that activation of the memory re...

  5. Astronautics summary and prospects

    CERN Document Server

    Kiselev, Anatoly Ivanovich; Menshikov, Valery Alexandrovich

    2003-01-01

    The monograph by A.I.Kiselev, A.A. Medvedev and Y.A.Menshikov, Astronautics: Summary and Prospects, aroused enthusiasm both among experts and the public at large. This is due to the felicitous choice of presentation that combines a simple description of complex space matters with scientificsubstantiation of the sub­ jectmatter described. The wealth of color photos makes the book still more attractive, and it was nominated for an award at the 14th International Moscow Book Fair, being singled out as the "best publication of the book fair". The book's popularity led to a second edition, substantially revised and enlarged. Since the first edition did not sufficiently cover the issues of space impact on ecology and the prospective development of space systems, the authors revised the entire volume, including in it the chapter "Space activity and ecology" and the section "Multi-function space systems". Using the federal monitoring system, now in the phase of system engi­ neering, as an example, the authors consi...

  6. A parameter-free analysis of the utility of money for the general population under prospect theory

    NARCIS (Netherlands)

    A.S. Booij; G. van de Kuilen

    2009-01-01

    Extensive data has convincingly demonstrated that expected utility, the reigning economic theory of rational decision making, fails descriptively. This descriptive failure casts doubt on the validity of classical utility measurements. Prospect theory can better explain choice behaviour because it ma

  7. Computer Education and Instructional Technology Prospective Teachers’ Perceptions of Technology

    Directory of Open Access Journals (Sweden)

    Ümmü Gülsüm DURUKAN

    2016-04-01

    Full Text Available The purpose of this study is to determine the “technology” perception of prospective computer and instructional technologies (CEIT teachers by metaphors. For this purpose the study was carried out with 53 first-year prospective teachers studying in the Department of CEIT in a public university in the fall term of 2014-2015 academic year. The forms consisting of the statement “Technology is like ……………because ………” written few times were used as a data collection tool. Phenomenography design was used in the study and the data were analyzed by content analysis. According to the study's findings, it was found that out of 118 valid metaphors developed by the prospective teachers, 103 of them were included in positive category, 7 were in negative category and 8 were in the neutral category.

  8. Prospective Memory Performance across Adolescence

    Science.gov (United States)

    Wang, Lijuan; Kliegel, Matthias; Yang, Zhiliang; Liu, Wei

    2006-01-01

    In the present study, the authors explored age differences in event-based prospective memory (PM) across adolescence. The tasks consisted of an ongoing task (OT; i.e., personality questionnaire items, math problems) and an embedded prospective task that required participants to remember to make a special response whenever they encountered a PM cue…

  9. Prospect Theory and Coercive Bargaining

    Science.gov (United States)

    Butler, Christopher K.

    2007-01-01

    Despite many applications of prospect theory's concepts to explain political and strategic phenomena, formal analyses of strategic problems using prospect theory are rare. Using Fearon's model of bargaining, Tversky and Kahneman's value function, and an existing probability weighting function, I construct a model that demonstrates the differences…

  10. Prospects at high energies

    International Nuclear Information System (INIS)

    I discuss some possibilities for neutrino experiments in the fixed-target environment of the SPS, Tevatron, and UNK, with their primary proton beams of 0.4, 0.9, and 3.0 TeV. The emphasis is on unfinished business: issues that have been recognized for some time, but not yet resolved. Then I turn to prospects for proton-proton colliders to explore the 1-TeV scale. I review the motivation for new physics in the neighborhood of 1 TeV and mention some discovery possibilities for high-energy, high-luminosity hadron colliders and the implications they would have for neutrino physics. I raise the possibility of the direct study of neutrino interactions in hadron colliders. I close with a report on the status of the SSC project. 38 refs., 17 figs

  11. Oil price prospects

    International Nuclear Information System (INIS)

    In this paper, four different, popular approaches to the analysis of oil price movements will be considered and an alternative method will be proposed. Whilst we await the development of a rigorous theoretical framework within which to evaluate the phenomenon of oil price movements some progress may be effected by an amalgam of approaches, with the traditional supply and demand model being supplemented by observations regarding political and social developments in particular countries or regions, together with an assessment of emerging and prospective technological achievements. In this way it should be possible to identify the critical influences at work, from which it should also be possible to select either the single most important variable or combination of variables, affecting the oil price. Moreover, it is my belief that the crucial variables influencing the oil price almost certainly, are more likely to be political and social, rather than economic. In this context and notwithstanding the fact that there is only a minimal level of surplus productive capacity in the world oil industry at present (perhaps 1-2 million b/d albeit rising rapidly), it is reasonable to conclude that oil prices will average around $18-19 a barrel for North Sea Brent in 1992 and 1993, with oscillations of $2-4 a barrel either side, rising slightly in 1994 to $19-20 a barrel and to $20-21 a barrel in 1995. Thereafter, the most likely outcome is for a rise in line with inflation (say $ a barrel/annum) with no prospect of an upward spike, because demand will be weaker than most commentators expect up to the year 2000, whilst OPEC oil supplies will be substantially higher than the consensus forecast. (author)

  12. Progress and prospects of calculation methods for radiation shielding

    International Nuclear Information System (INIS)

    Progress in calculation methods for radiation shielding are reviewed based on the activities of research committees related to radiation shielding fields established in the Atomic Energy Society of Japan. A technological roadmap for the field of radiation shielding; progress and prospects for specific shielding calculation methods such as the Monte Carlo, discrete ordinate Sn transport, and simplified methods; and shielding experiments used to validate calculation methods are presented in this paper. (author)

  13. Prospective GIS modelling of land cover in Mediterranean mountain regions

    OpenAIRE

    Paegelow, Martin

    2003-01-01

    International audience; GIS includes among the variety of analytical functions those intended to spatial-temporal modelling and decision support. This paper focus on GIS methods and results of prospective land cover modelling applied to a mountain basin in Eastern Pyrenees (France). This research is a part of an international project between France and Spain focusing on development, validation and comparison of 3 different methods for environmental modelling (statistical approach by non linea...

  14. Prospect theory in the health domain: A quantitative assessment

    OpenAIRE

    Attema, Arthur; Brouwer, Werner; L'Haridon, Olivier

    2013-01-01

    International audience It is well-known that expected utility (EU) has empirical deficiencies. Cumulative prospect, theory (CPT) has developed as an alternative with more descriptive validity. However, CPT's full, function had not yet been quantified in the health domain. This paper is therefore the first to, simultaneously measure utility of life duration, probability weighting, and loss aversion in this domain., We observe loss aversion and risk aversion for gains and losses, which for g...

  15. A quantification of prospect theory in the health domain

    OpenAIRE

    Attema, Arthur E.; Werner B.F. Brouwer; Olivier L'Haridon

    2013-01-01

    It is well-known that expected utility (EU) has empirical deficiencies. Prospect theory (PT) has developed as an alternative with more descriptive validity. However, PT’s full function had not yet been quantified in the health domain. This paper is therefore the first to simultaneously measure utility of life duration, probability weighting, and loss aversion in the health domain. We observe loss aversion and risk aversion for gains and losses, which for gains can be explained by probabilisti...

  16. Psychological Test Validity

    Directory of Open Access Journals (Sweden)

    Gessmann H.-W.

    2015-02-01

    Full Text Available This paper presents a theoretical overview of current aspects about the validity problems of psychological tests. The article demonstrates the importance of the development of psychological tests and the scientific studies of their validity, describes the different types of validity and the possible ways of measurement and determination of the validity coefficients. The paper is recommended for researchers, whose work is dedicated to the development, modification or adaptation of the psychological test.

  17. The Concept of Validity

    Science.gov (United States)

    Borsboom, Denny; Mellenbergh, Gideon J.; van Heerden, Jaap

    2004-01-01

    This article advances a simple conception of test validity: A test is valid for measuring an attribute if (a) the attribute exists and (b) variations in the attribute causally produce variation in the measurement outcomes. This conception is shown to diverge from current validity theory in several respects. In particular, the emphasis in the…

  18. Validity of a short questionnaire to assess physical activity in 10 European countries

    NARCIS (Netherlands)

    Feskens, E.J.M.

    2012-01-01

    To accurately examine associations of physical activity (PA) with disease outcomes, a valid method of assessing free-living activity is required. We examined the validity of a brief PA questionnaire (PAQ) used in the European Prospective Investigation into Cancer and Nutrition (EPIC). PA energy expe

  19. ANAIS: Status and prospects

    Science.gov (United States)

    Amaré, J.; Cebrián, S.; Cuesta, C.; García, E.; Ginestra, C.; Martínez, M.; Oliván, M. A.; Ortigoza, Y.; Ortiz de Solórzano, A.; Pobes, C.; Puimedón, J.; Sarsa, M. L.; Villar, J. A.; Villar, P.

    2016-07-01

    ANAIS experiment will look for dark matter annual modulation with large mass of ultra-pure NaI(Tl) scintillators at the Canfranc Underground Laboratory (LSC), aiming to confirm the DAMA/LIBRA positive signal in a model-independent way. Two 12.5 kg each NaI(Tl) crystals provided by Alpha Spectra are currently taking data at the LSC. Present status of ANAIS detectors background and general performance is summarized; in particular, thanks to the high light collection efficiency prospects of lowering the threshold down to 1 keVee are reachable. Crystal radiopurity goals are fulfilled for 232Th and 238U chains and 40K activity, although higher than original goal, could be accepted; however, high 210Pb contamination out-of-equilibrium has been identified. More radiopure detectors are being built by Alpha Spectra. The ongoing high quantum efficiency PMT tests and muon veto characterization are also presented. Finally, the sensitivity of the experiment for the annual modulation in the WIMP signal, assuming the already achieved threshold and background in ANAIS-25 is shown. Further improvement should be achieved by reducing both threshold and background, as expected.

  20. ANAIS: Status and prospects

    CERN Document Server

    Amaré, Julio; Cuesta, Clara; García, Eduardo; Ginestra, Carlos; Martínez, María; Oliván, Miguel A; Ortigoza, Ysrael; de Solórzano, Alfonso Ortíz; Pobes, Carlos; Puimedón, Jorge; Sarsa, María Luisa; Villar, José Ángel; Villar, Patricia

    2015-01-01

    ANAIS experiment will look for dark matter annual modulation with large mass of ultra-pure NaI(Tl) scintillators at the Canfranc Underground Laboratory (LSC), aiming to confirm the DAMA/LIBRA positive signal in a model-independent way. Two 12.5 kg each NaI(Tl) crystals provided by Alpha Spectra are currently taking data at the LSC. Present status of ANAIS detectors background and general performance is summarized; in particular, thanks to the high light collection efficiency prospects of lowering the threshold down to 1 keVee are reachable. Crystal radiopurity goals are fulfilled for $^{232}$Th and $^{238}$U chains and $^{40}$K activity, although higher than original goal, could be accepted; however, high $^{210}$Pb contamination out-of-equilibrium has been identified. More radiopure detectors are being built by Alpha Spectra. The ongoing high quantum efficiency PMT tests and muon veto characterization are also presented. Finally, the sensitivity of the experiment for the annual modulation in the WIMP signal,...

  1. German energy technology prospects.

    Science.gov (United States)

    Popp, M

    1982-12-24

    After more than 25 years of development of nuclear power and almost 10 years of research and development in numerous areas of nonnuclear energy, there is now a good basis for judging the future prospects of energy technologies in the Federal Republic of Germany. The development of nuclear power has provided an important and economically advantageous new source of energy. Further efforts are needed to establish the nuclear fuel cycle in all stages and to exploit the potential of advanced reactors. In all other areas of energy technology, including energy conservation, new energy sources, and coal, economics has turned out to be the key problem, even at today's energy prices. Opportunities to overcome these economic problems through additional R & D are limited. There is some potential for special applications, and there are many technologies that could contribute to the energy supply of developing countries. In general, however, progress in energy conservation and the use of renewable energy sources will depend on the degree to which energy policy measures can improve their economic basis. For some technologies, such as solar thermal power stations and coal liquefaction, large-scale economic deployment cannot be foreseen today. Instead of establishing costly demonstration projects, emphasis will be put on improving key components of these technologies with the aim of having the most advanced technology available when the economic parameters are more favorable.

  2. Fuel cells: Problems and prospects

    OpenAIRE

    Shukla, AK; Ramesh, KV; Kannan, AM

    1986-01-01

    n recent years, fuel cell technology has advanced significantly. Field trials on certain types of fuel cells have shown promise for electrical use. This article reviews the electrochemistry, problems and prospects of fuel cell systems.

  3. Prospect of ultralight airplanes development

    Directory of Open Access Journals (Sweden)

    Adam KONICZEK

    2015-09-01

    Full Text Available The article presents characteristic of ultralight airplanes, rules and current interest of them. The purpose is to determine prospect of ultralight airplanes development on the basis of Civil Aviation Authority statistics analysis and trend of aviation market.

  4. Work ethics: An Islamic prospective

    OpenAIRE

    Muhammad Shakil Ahmad

    2011-01-01

    Islamic principles completely cover all prospects of life including working in organization. The impact of management style used in an organization play an important role in employee commitment towards its work. This paper is an effort to explore impact of Islamic work ethic on human resource of organization including the prospective of work conflict, job satisfaction, job turn over, turnover intentions and organizational commitment. Data for current study was collected personally through que...

  5. Prospective Mathematics Teachers' Opinions on

    OpenAIRE

    Ali Eraslan

    2009-01-01

    The aim of this study is to investigate the opinions of prospective mathematics teachers in Teaching Practice course taken at the last semester of the teacher education program. For this purpose, 47 prospective teachers taking Teaching Practice wrote and submitted one or two-page reflection of their school-based experiences at the end of the semester. Their written responses were examined and analyzed qualitatively. Findings indicated that (1) there exist not enough opportunities for practice...

  6. Comments on model validation

    International Nuclear Information System (INIS)

    The paper points out the importance and usefulness of recognizing the separate roles of processes and geometric structures in predictive modeling of the performance of a nuclear waste repository or underground injection disposal of toxic wastes. Based on this a validation procedure is proposed. Furthermore, two stages and three elements of validation are described and discussed. Finally, comments are made on the choice of measurables to be used to compare modeling results and field data in the validation procedure. 8 refs

  7. Resolution in Electromagnetic Prospecting

    Science.gov (United States)

    Aldridge, D. F.; Bartel, L. C.; Knox, H. A.; Schramm, K. A.

    2014-12-01

    Low-frequency electromagnetic (EM) signals are commonly used in geophysical exploration of the shallow subsurface. Sensitivity to conductivity implies they are particularly useful for inferring fluid content of porous media. However, low-frequency EM wavefields are diffusive, and have significantly larger wavelengths compared to seismic signals of equal frequency. The wavelength of a 30 Hz sinusoid propagating with seismic velocity 3000 m/s is 100 m, whereas an analogous EM signal diffusing through a conductive body of 0.1 S/m (clayey shale) has wavelength 1825 m. The larger wavelength has implications for resolution of the EM prospecting method. We are investigating resolving power of the EM method via theoretical and numerical experiments. Normal incidence plane wave reflection/transmission by a thin geologic bed is amenable to analytic solution. Responses are calculated for beds that are conductive or resistive relative to the host rock. Preliminary results indicate the classic seismic resolution/detection limit of bed thickness ~1/8 wavelength is not achieved. EM responses for point or line current sources recorded by general acquisition geometries are calculated with a 3D finite-difference algorithm. These exhibit greater variability which may allow inference of bed thickness. We also examine composite responses of two point scatterers with separation when illuminated by an incident EM field. This is analogous to the Rayleigh resolution problem of estimating angular separation between two light sources. The First Born Approximation implies that perturbations in permittivity, permeability, and conductivity have different scattering patterns, which may be indicators of EM medium properties. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the US Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

  8. Validation of HEDR models

    International Nuclear Information System (INIS)

    The Hanford Environmental Dose Reconstruction (HEDR) Project has developed a set of computer models for estimating the possible radiation doses that individuals may have received from past Hanford Site operations. This document describes the validation of these models. In the HEDR Project, the model validation exercise consisted of comparing computational model estimates with limited historical field measurements and experimental measurements that are independent of those used to develop the models. The results of any one test do not mean that a model is valid. Rather, the collection of tests together provide a level of confidence that the HEDR models are valid

  9. Validation of simulation models

    DEFF Research Database (Denmark)

    Rehman, Muniza; Pedersen, Stig Andur

    2012-01-01

    of models with regards to their purpose, character, field of application and time dimension inherently calls for a similar diversity in validation approaches. A classification of models in terms of the mentioned elements is presented and used to shed light on possible types of validation leading...... of models has been somewhat narrow-minded reducing the notion of validation to establishment of truth. This article puts forward the diversity in applications of simulation models that demands a corresponding diversity in the notion of validation....

  10. Validation of HEDR models

    International Nuclear Information System (INIS)

    The Hanford Environmental Dose Reconstruction (HEDR) Project has developed a set of computer models for estimating the possible radiation doses that individuals may have received from past Hanford Site operations. This document describes the validation of these models. In the HEDR Project, the model validation exercise consisted of comparing computational model predictions with limited historical field measurements and experimental measurements that are independent of those used to develop the models. The results of any one test do not mean that a model is valid. Rather, the collection of tests together provide a level of confidence that the HEDR models are valid

  11. SOSS ICN Model Validation

    Science.gov (United States)

    Zhu, Zhifan

    2016-01-01

    Under the NASA-KAIA-KARI ATM research collaboration agreement, SOSS ICN Model has been developed for Incheon International Airport. This presentation describes the model validation work in the project. The presentation will show the results and analysis of the validation.

  12. An SAT® Validity Primer

    Science.gov (United States)

    Shaw, Emily J.

    2015-01-01

    This primer should provide the reader with a deeper understanding of the concept of test validity and will present the recent available validity evidence on the relationship between SAT® scores and important college outcomes. In addition, the content examined on the SAT will be discussed as well as the fundamental attention paid to the fairness of…

  13. Checklists for external validity

    DEFF Research Database (Denmark)

    Dyrvig, Anne-Kirstine; Kidholm, Kristian; Gerke, Oke;

    2014-01-01

    RATIONALE, AIMS AND OBJECTIVES: The quality of the current literature on external validity varies considerably. An improved checklist with validated items on external validity would aid decision-makers in judging similarities among circumstances when transferring evidence from a study setting...... to an implementation setting. In this paper, currently available checklists on external validity are identified, assessed and used as a basis for proposing a new improved instrument. METHOD: A systematic literature review was carried out in Pubmed, Embase and Cinahl on English-language papers without time restrictions....... The retrieved checklist items were assessed for (i) the methodology used in primary literature, justifying inclusion of each item; and (ii) the number of times each item appeared in checklists. RESULTS: Fifteen papers were identified, presenting a total of 21 checklists for external validity, yielding a total...

  14. Model Validation Status Review

    Energy Technology Data Exchange (ETDEWEB)

    E.L. Hardin

    2001-11-28

    The primary objective for the Model Validation Status Review was to perform a one-time evaluation of model validation associated with the analysis/model reports (AMRs) containing model input to total-system performance assessment (TSPA) for the Yucca Mountain site recommendation (SR). This review was performed in response to Corrective Action Request BSC-01-C-01 (Clark 2001, Krisha 2001) pursuant to Quality Assurance review findings of an adverse trend in model validation deficiency. The review findings in this report provide the following information which defines the extent of model validation deficiency and the corrective action needed: (1) AMRs that contain or support models are identified, and conversely, for each model the supporting documentation is identified. (2) The use for each model is determined based on whether the output is used directly for TSPA-SR, or for screening (exclusion) of features, events, and processes (FEPs), and the nature of the model output. (3) Two approaches are used to evaluate the extent to which the validation for each model is compliant with AP-3.10Q (Analyses and Models). The approaches differ in regard to whether model validation is achieved within individual AMRs as originally intended, or whether model validation could be readily achieved by incorporating information from other sources. (4) Recommendations are presented for changes to the AMRs, and additional model development activities or data collection, that will remedy model validation review findings, in support of licensing activities. The Model Validation Status Review emphasized those AMRs that support TSPA-SR (CRWMS M&O 2000bl and 2000bm). A series of workshops and teleconferences was held to discuss and integrate the review findings. The review encompassed 125 AMRs (Table 1) plus certain other supporting documents and data needed to assess model validity. The AMRs were grouped in 21 model areas representing the modeling of processes affecting the natural and

  15. Model Validation Status Review

    International Nuclear Information System (INIS)

    The primary objective for the Model Validation Status Review was to perform a one-time evaluation of model validation associated with the analysis/model reports (AMRs) containing model input to total-system performance assessment (TSPA) for the Yucca Mountain site recommendation (SR). This review was performed in response to Corrective Action Request BSC-01-C-01 (Clark 2001, Krisha 2001) pursuant to Quality Assurance review findings of an adverse trend in model validation deficiency. The review findings in this report provide the following information which defines the extent of model validation deficiency and the corrective action needed: (1) AMRs that contain or support models are identified, and conversely, for each model the supporting documentation is identified. (2) The use for each model is determined based on whether the output is used directly for TSPA-SR, or for screening (exclusion) of features, events, and processes (FEPs), and the nature of the model output. (3) Two approaches are used to evaluate the extent to which the validation for each model is compliant with AP-3.10Q (Analyses and Models). The approaches differ in regard to whether model validation is achieved within individual AMRs as originally intended, or whether model validation could be readily achieved by incorporating information from other sources. (4) Recommendations are presented for changes to the AMRs, and additional model development activities or data collection, that will remedy model validation review findings, in support of licensing activities. The Model Validation Status Review emphasized those AMRs that support TSPA-SR (CRWMS M and O 2000bl and 2000bm). A series of workshops and teleconferences was held to discuss and integrate the review findings. The review encompassed 125 AMRs (Table 1) plus certain other supporting documents and data needed to assess model validity. The AMRs were grouped in 21 model areas representing the modeling of processes affecting the natural and

  16. PROSPECTIVE ISLAMIC LAW IN INDONESIA

    Directory of Open Access Journals (Sweden)

    Mohdar Yanlua

    2015-02-01

    Full Text Available This paper discusses the Prospective Islamic law in Indonesia. The enforcement of Islamic law in Indonesia experienced the ups and downs, ranging from the colonial period with the Government of Indonesia to the Netherlands in order to reform it.In this study it was found that a prospective law of Islam in Indonesia the development of any regime of the Government of Indonesia is experiencing developments. By the Government of Indonesia does not accept or reject the extremes, but instead selectively receive (not the totality and gradual.Such a step is done for the sake of maintaining the stability and integrity of the country.

  17. Introduction to Validity

    Institute of Scientific and Technical Information of China (English)

    张楠

    2015-01-01

    The designing of a test paper strictly follows the specification of the relevant Testing Syllabus, which covers various skills and abilities needed for real communicative situation. A test with high content validity is likely to have a positive impact upon the teaching. Therefore, a test with a high content validity will undoubtedly promote the college English education and it will certainly facilitate the implementation of the Syllabus.

  18. Verification and validation benchmarks.

    Energy Technology Data Exchange (ETDEWEB)

    Oberkampf, William Louis; Trucano, Timothy Guy

    2007-02-01

    Verification and validation (V&V) are the primary means to assess the accuracy and reliability of computational simulations. V&V methods and procedures have fundamentally improved the credibility of simulations in several high-consequence fields, such as nuclear reactor safety, underground nuclear waste storage, and nuclear weapon safety. Although the terminology is not uniform across engineering disciplines, code verification deals with assessing the reliability of the software coding, and solution verification deals with assessing the numerical accuracy of the solution to a computational model. Validation addresses the physics modeling accuracy of a computational simulation by comparing the computational results with experimental data. Code verification benchmarks and validation benchmarks have been constructed for a number of years in every field of computational simulation. However, no comprehensive guidelines have been proposed for the construction and use of V&V benchmarks. For example, the field of nuclear reactor safety has not focused on code verification benchmarks, but it has placed great emphasis on developing validation benchmarks. Many of these validation benchmarks are closely related to the operations of actual reactors at near-safety-critical conditions, as opposed to being more fundamental-physics benchmarks. This paper presents recommendations for the effective design and use of code verification benchmarks based on manufactured solutions, classical analytical solutions, and highly accurate numerical solutions. In addition, this paper presents recommendations for the design and use of validation benchmarks, highlighting the careful design of building-block experiments, the estimation of experimental measurement uncertainty for both inputs and outputs to the code, validation metrics, and the role of model calibration in validation. It is argued that the understanding of predictive capability of a computational model is built on the level of

  19. Validation suite for MCNP

    Energy Technology Data Exchange (ETDEWEB)

    Mosteller, R. D. (Russell D.)

    2002-01-01

    Two validation suites, one for criticality and another for radiation shielding, have been defined and tested for the MCNP Monte Carlo code. All of the cases in the validation suites are based on experiments so that calculated and measured results can be compared in a meaningful way. The cases in the validation suites are described, and results from those cases are discussed. For several years, the distribution package for the MCNP Monte Carlo code1 has included an installation test suite to verify that MCNP has been installed correctly. However, the cases in that suite have been constructed primarily to test options within the code and to execute quickly. Consequently, they do not produce well-converged answers, and many of them are physically unrealistic. To remedy these deficiencies, sets of validation suites are being defined and tested for specific types of applications. All of the cases in the validation suites are based on benchmark experiments. Consequently, the results from the measurements are reliable and quantifiable, and calculated results can be compared with them in a meaningful way. Currently, validation suites exist for criticality and radiation-shielding applications.

  20. Work-site musculoskeletal pain risk estimates by trained observers - a prospective cohort study

    NARCIS (Netherlands)

    Coenen, P.; Kingma, I.; Boot, C.R.L.; Douwes, M.; Bongers, P.M.; Dieën, J.H. van

    2012-01-01

    Work-related musculoskeletal pain (MSP) risk assessments by trained observers are often used in ergonomic practice; however, the validity may be questionable. We investigated the predictive value of work-site MSP risk estimates in a prospective cohort study of 1745 workers. Trained observers estimat

  1. Prospective Teachers' Conceptions of Teaching and Learning Revealed through Metaphor Analysis

    Science.gov (United States)

    Saban, Ahmet; Kocbeker, Beyhan Nazli; Saban, Aslihan

    2007-01-01

    This study investigated the metaphors that prospective teachers in Turkey (N = 1,142) formulated to describe the concept of "teacher". Participants completed the prompt "A teacher is like...because..." by focusing on only one metaphor to indicate their conceptualization of teaching and learning. Altogether 64 valid personal metaphors were analyzed…

  2. The value of subjectivity: problems and prospects for 360-degree appraisal systems

    NARCIS (Netherlands)

    Heijden, van der Beatrice I.J.M.; Nijhof, André H.J.

    2004-01-01

    This article focuses on the problems and prospects of 360-degree feedback methods. The rationale behind these appraisal systems is that different evaluation perspectives add objectivity and incremental validity to the assessment of individual performance. This assumption is challenged in this articl

  3. Revisiting the age-prospective memory-paradox: the role of planning and task experience

    NARCIS (Netherlands)

    Hering, A.; Cortez, S.A.; Kliegel, M.; Altgassen, A.M.

    2014-01-01

    The present study aimed at investigating age-related differences in prospective memory performance using a paradigm with high ecological validity and experimental control. Thirty old and 30 young adults completed the Dresden Breakfast task; a meal preparation task in the lab that comprises several s

  4. Job Prospects for Civil Engineers.

    Science.gov (United States)

    Basta, Nicholas

    1985-01-01

    Government programs and renewed industrial activity have combined with stable enrollments to create bright job prospects for civil engineers. Areas with good opportunities include highway reconstruction and rehabilitation, water-resource management, and new factory construction. The subspecialty of structural engineering has a growing need in…

  5. Rose breeding: past, present, prospects

    NARCIS (Netherlands)

    Vries, de D.P.; Dubois, L.A.M.

    1996-01-01

    In this review the PAST, PRESENT and PROSPECT will be considered as three separate periods in the history of the breeding and development of rose cultivars. The recurring theme is the genetic variation. This theme was chosen because there is justified doubt as to sufficient genetic variation availab

  6. The UK Prospective Diabetes Study

    DEFF Research Database (Denmark)

    Olivarius, Niels de Fine; Andreasen, A.H.

    1998-01-01

    Læserbrev, som kritiserer det store UK Prospective Diabetes Study's forfattere for at overfortolke deres fund, idet marginalt signifikante p-værdier tages som udtryk for slående effekt (af at sænke blodsukkeret). Det sker selvom der f.eks. indgår effektvariabler, som kunne påvirkes af patienternes...

  7. Pre- and post-drill comparison of the Mount Elbert gas hydrate prospect, Alaska North Slope

    Science.gov (United States)

    Lee, M.W.; Agena, W.F.; Collett, T.S.; Inks, T.L.

    2011-01-01

    In 2006, the United States Geological Survey (USGS) completed a detailed analysis and interpretation of available 2-D and 3-D seismic data, along with seismic modeling and correlation with specially processed downhole well log data for identifying potential gas hydrate accumulations on the North Slope of Alaska. A methodology was developed for identifying sub-permafrost gas hydrate prospects within the gas hydrate stability zone in the Milne Point area. The study revealed a total of 14 gas hydrate prospects in this area.In order to validate the gas hydrate prospecting protocol of the USGS and to acquire critical reservoir data needed to develop a longer-term production testing program, a stratigraphic test well was drilled at the Mount Elbert prospect in the Milne Point area in early 2007. The drilling confirmed the presence of two prominent gas-hydrate-bearing units in the Mount Elbert prospect, and high quality well logs and core data were acquired. The post-drill results indicate pre-drill predictions of the reservoir thickness and the gas-hydrate saturations based on seismic and existing well data were 90% accurate for the upper unit (hydrate unit D) and 70% accurate for the lower unit (hydrate unit C), confirming the validity of the USGS approach to gas hydrate prospecting. The Mount Elbert prospect is the first gas hydrate accumulation on the North Slope of Alaska identified primarily on the basis of seismic attribute analysis and specially processed downhole log data. Post-drill well log data enabled a better constraint of the elastic model and the development of an improved approach to the gas hydrate prospecting using seismic attributes. ?? 2009.

  8. Prospective Memory: The Future for Future Intentions

    OpenAIRE

    Gil Gonen-Yaacovi; Burgess, Paul W.

    2012-01-01

    Prospective memory is the ability to remember to execute future intentions and thoughts. It is probably the newest established field of memory research. We provide a selective review of work conducted in the last two decades with respect to the following issues: (1) the different types and characteristics of prospective tasks, (2) the theoretical models of the cognitive processes supporting prospective memory, (3) prospective memory performance in younger and older adults and (4) the findings...

  9. Prospective Memory Training in Older Adults.

    Science.gov (United States)

    Schmidt, Iris W.; Berg, Ina J.; Deelman, Betto G.

    2001-01-01

    Twenty adults received training in prospective memory; 23 who received training in reducing worries about forgetfulness and 22 controls formed a comparison group. Results of a telephone task and a prospective categorization task revealed significant but small effects for the prospective memory group. After 3 months, the comparison group's…

  10. Containment Code Validation Matrix

    International Nuclear Information System (INIS)

    The Committee on the Safety of Nuclear Installations (CSNI) formed the CCVM (Containment Code Validation Matrix) task group in 2002. The objective of this group was to define a basic set of available experiments for code validation, covering the range of containment (ex-vessel) phenomena expected in the course of light and heavy water reactor design basis accidents and beyond design basis accidents/severe accidents. It was to consider phenomena relevant to pressurised heavy water reactor (PHWR), pressurised water reactor (PWR) and boiling water reactor (BWR) designs of Western origin as well as of Eastern European VVER types. This work would complement the two existing CSNI validation matrices for thermal hydraulic code validation (NEA/CSNI/R(1993)14) and In-vessel core degradation (NEA/CSNI/R(2001)21). The report initially provides a brief overview of the main features of a PWR, BWR, CANDU and VVER reactors. It also provides an overview of the ex-vessel corium retention (core catcher). It then provides a general overview of the accident progression for light water and heavy water reactors. The main focus is to capture most of the phenomena and safety systems employed in these reactor types and to highlight the differences. This CCVM contains a description of 127 phenomena, broken down into 6 categories: - Containment Thermal-hydraulics Phenomena; - Hydrogen Behaviour (Combustion, Mitigation and Generation) Phenomena; - Aerosol and Fission Product Behaviour Phenomena; - Iodine Chemistry Phenomena; - Core Melt Distribution and Behaviour in Containment Phenomena; - Systems Phenomena. A synopsis is provided for each phenomenon, including a description, references for further information, significance for DBA and SA/BDBA and a list of experiments that may be used for code validation. The report identified 213 experiments, broken down into the same six categories (as done for the phenomena). An experiment synopsis is provided for each test. Along with a test description

  11. Validation of Serious Games

    Directory of Open Access Journals (Sweden)

    Katinka van der Kooij

    2015-09-01

    Full Text Available The application of games for behavioral change has seen a surge in popularity but evidence on the efficacy of these games is contradictory. Anecdotal findings seem to confirm their motivational value whereas most quantitative findings from randomized controlled trials (RCT are negative or difficult to interpret. One cause for the contradictory evidence could be that the standard RCT validation methods are not sensitive to serious games’ effects. To be able to adapt validation methods to the properties of serious games we need a framework that can connect properties of serious game design to the factors that influence the quality of quantitative research outcomes. The Persuasive Game Design model [1] is particularly suitable for this aim as it encompasses the full circle from game design to behavioral change effects on the user. We therefore use this model to connect game design features, such as the gamification method and the intended transfer effect, to factors that determine the conclusion validity of an RCT. In this paper we will apply this model to develop guidelines for setting up validation methods for serious games. This way, we offer game designers and researchers handles on how to develop tailor-made validation methods.

  12. Shift Verification and Validation

    Energy Technology Data Exchange (ETDEWEB)

    Pandya, Tara M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Evans, Thomas M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Davidson, Gregory G [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Johnson, Seth R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Godfrey, Andrew T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-09-07

    This documentation outlines the verification and validation of Shift for the Consortium for Advanced Simulation of LightWater Reactors (CASL). Fivemain types of problems were used for validation: small criticality benchmark problems; full-core reactor benchmarks for light water reactors; fixed source coupled neutron-photon dosimetry benchmarks; depletion/burnup benchmarks; and full-core reactor performance benchmarks. We compared Shift results to measured data and other simulated Monte Carlo radiation transport code results and found very good agreement in a variety of comparison measures. These include prediction of critical eigenvalue, radial and axial pin power distributions, rod worth, leakage spectra, and nuclide inventories over a burn cycle. Based on this validation of Shift, we are confident in Shift to provide reference results for CASL benchmarking.

  13. Validation and Variability

    DEFF Research Database (Denmark)

    Carusi, Annamaria

    2014-01-01

    as inter-subject variability. This need is simultaneously social and epistemic: social as systems biologists attempt to engage with the interests and concerns of clinicians and others in applied medical research; epistemic as they attempt to develop new strategies to cope with variability in the validation...... and experimentally inclined modellers on one hand, and attempts to forge new collaborations with medical scientists on the other. Apart from the scientific interest of the population of models approach for tackling variability, the trial also offers a good illustration of the epistemology of experiment......-facing modelling. I claim that it shows the extent to which experiment-facing modelling and validation require the establishment of criteria for comparing models and experiments that enable them to be linked together. These 'grounds of comparability' are the broad framework in which validation experiments...

  14. Rapid Robot Design Validation Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Energid Technologies will create a comprehensive software infrastructure for rapid validation of robotic designs. The software will support push-button validation...

  15. Rapid Robot Design Validation Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Energid Technologies will create a comprehensive software infrastructure for rapid validation of robot designs. The software will support push-button validation...

  16. Validating Animal Models

    Directory of Open Access Journals (Sweden)

    Nina Atanasova

    2015-06-01

    Full Text Available In this paper, I respond to the challenge raised against contemporary experimental neurobiology according to which the field is in a state of crisis because of the multiple experimental protocols employed in different laboratories and strengthening their reliability that presumably preclude the validity of neurobiological knowledge. I provide an alternative account of experimentation in neurobiology which makes sense of its experimental practices. I argue that maintaining a multiplicity of experimental protocols and strengthening their reliability are well justified and they foster rather than preclude the validity of neurobiological knowledge. Thus, their presence indicates thriving rather than crisis of experimental neurobiology.

  17. The validation of metaphors

    OpenAIRE

    Verhulst, F.

    2001-01-01

    In this paper we introduce models as metaphors for the description of reality We consider a number of case studies of contemporary research pollution of the NorthSea the ow eld of theWadden Sea drillstring dynamics the use of metaphors in psychoanalysis In all these cases validation of the results takes a very dierent form Also this validation is certainly not in agreement with the picture of scienti c research projected by textbook examples In the discussion we draw some conclusions on the u...

  18. The dialogic validation

    DEFF Research Database (Denmark)

    Musaeus, Peter

    2005-01-01

    This paper is inspired by dialogism and the title is a paraphrase on Bakhtin's (1981) "The Dialogic Imagination". The paper investigates how dialogism can inform the process of validating inquiry-based qualitative research. The paper stems from a case study on the role of recognition in apprentic......This paper is inspired by dialogism and the title is a paraphrase on Bakhtin's (1981) "The Dialogic Imagination". The paper investigates how dialogism can inform the process of validating inquiry-based qualitative research. The paper stems from a case study on the role of recognition...

  19. Prospects for Future Collider Physics

    CERN Document Server

    Ellis, John

    2016-01-01

    One item on the agenda of future colliders is certain to be the Higgs boson. What is it trying to tell us? The primary objective of any future collider must surely be to identify physics beyond the Standard Model, and supersymmetry is one of the most studied options. it Is supersymmetry waiting for us and, if so, can LHC Run 2 find it? The big surprise from the initial 13-TeV LHC data has been the appearance of a possible signal for a new boson X with a mass ~750 GeV. What are the prospects for future colliders if the X(750) exists? One of the most intriguing possibilities in electroweak physics would be the discovery of non-perturbative phenomena. What are the prospects for observing sphalerons at the LHC or a future collider?

  20. Prospective Mathematics Teachers' Opinions on

    Directory of Open Access Journals (Sweden)

    Ali Eraslan

    2009-06-01

    Full Text Available The aim of this study is to investigate the opinions of prospective mathematics teachers in Teaching Practice course taken at the last semester of the teacher education program. For this purpose, 47 prospective teachers taking Teaching Practice wrote and submitted one or two-page reflection of their school-based experiences at the end of the semester. Their written responses were examined and analyzed qualitatively. Findings indicated that (1 there exist not enough opportunities for practice teaching, little or no feedback from their supervising teachers, no links between pure mathematics courses and school mathematics. On the other hand, they stated that they get benefit from the teaching courses such as Teaching Methodology I-II, and Instructional Technology and Developing Materials, feel like the real teacher of their classrooms and get to know more about the real classroom environment and school students. Key words:

  1. Prospects for an independent Kurdistan?

    OpenAIRE

    Lewis, Robert P.

    2008-01-01

    The last ninety years of Kurdish history demonstrates their political progression towards statehood. Examination of this history and US policy during this period allows us to analyze the circumstances that prevented Kurdish statehood. The three levels of analysis utilized allow analysis of Kurdish history with regards to the individual, the state and the international system. Such analysis assists in determining the prospect for independence of the Iraqi Kurds today. An Iraqi Kurdish declara...

  2. Antiaging therapy: a prospective hypothesis

    OpenAIRE

    Shahidi Bonjar MR; Shahidi Bonjar L

    2015-01-01

    Mohammad Rashid Shahidi Bonjar,1 Leyla Shahidi Bonjar2 1School of Dentistry, Kerman University of Medical Sciences, Kerman Iran; 2Department of Pharmacology, College of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran Abstract: This hypothesis proposes a new prospective approach to slow the aging process in older humans. The hypothesis could lead to developing new treatments for age-related illnesses and help humans to live longer. This hypothesis has no previous docum...

  3. Prospects for nuclear safety research

    Energy Technology Data Exchange (ETDEWEB)

    Beckjord, E.S.

    1995-04-01

    This document is the text of a paper presented by Eric S. Beckjord (Director, Nuclear Regulatory Research/NRC) at the 22nd Water Reactor Safety Meeting in Bethesda, MD in October 1994. The following topics are briefly reviewed: (1) Reactor vessel research, (2) Probabilistic risk assessment, (3) Direct containment heating, (4) Advanced LWR research, (5) Nuclear energy prospects in the US, and (6) Future nuclear safety research. Subtopics within the last category include economics, waste disposal, and health and safety.

  4. Validation and test report

    DEFF Research Database (Denmark)

    Pedersen, Jens Meldgaard; Andersen, T. Bull

    2012-01-01

    . As a consequence of extensive movement artefacts seen during dynamic contractions, the following validation and test report consists of a report that investigates the physiological responses to a static contraction in a standing and a supine position. Eight subjects performed static contractions of the ankle...

  5. The validation of metaphors

    NARCIS (Netherlands)

    Verhulst, F.

    2001-01-01

    In this paper we introduce models as metaphors for the description of reality We consider a number of case studies of contemporary research pollution of the NorthSea the ow eld of theWadden Sea drillstring dynamics the use of metaphors in psychoanalysis In all these cases validation of the resu

  6. Neurofilament ELISA validation.

    NARCIS (Netherlands)

    Petzold, A.; Altintas, A.; Andreoni, L.; Bartos, A.; Berthele, A.; Blankenstein, M.A.; Buee, L.; Castellazzi, M.; Cepok, S.; Comabella, M.; Constantinescu, C.S.; Deisenhammer, F.; Deniz, G.; Erten, G.; Espino, M.; Fainardi, E.; Franciotta, D.; Freedman, M.S.; Giedraitis, V.; Gilhus, N.E.; Giovannoni, G.; Glabinski, A.; Grieb, P.; Hartung, H.P.; Hemmer, B.; Herukka, S.K.; Hintzen, R.; Ingelsson, M.; Jackson, S.; Jacobsen, S.; Jafari, N.; Jalosinski, M.; Jarius, S.; Kapaki, E.; Kieseier, B.C.; Koel-Simmelink, M.J.; Kornhuber, J.; Kuhle, J.; Kurzepa, J.; Lalive, P.H.; Lannfelt, L.; Lehmensiek, V.; Lewczuk, P.; Livrea, P.; Marnetto, F.; Martino, D.; Menge, T.; Norgren, N.; Papuc, E.; Paraskevas, G.P.; Pirttila, T.; Rajda, C.; Rejdak, K.; Ricny, J.; Ripova, D.; Rosengren, L.; Ruggieri, M.; Schraen, S.; Shaw, G.; Sindic, C.; Siva, A.; Stigbrand, T.; Stonebridge, I.; Topcular, B.; Trojano, M.; Tumani, H.; Twaalfhoven, H.A.; Vecsei, L.; Pesch, V. Van; Stichele, H. van der; Vedeler, C.; Verbeek, M.M.; Villar, L.M.; Weissert, R.; Wildemann, B.; Yang, C.; Yao, K.; Teunissen, C.E.

    2010-01-01

    BACKGROUND: Neurofilament proteins (Nf) are highly specific biomarkers for neuronal death and axonal degeneration. As these markers become more widely used, an inter-laboratory validation study is required to identify assay criteria for high quality performance. METHODS: The UmanDiagnostics NF-light

  7. The Chimera of Validity

    Science.gov (United States)

    Baker, Eva L.

    2013-01-01

    Background/Context: Education policy over the past 40 years has focused on the importance of accountability in school improvement. Although much of the scholarly discourse around testing and assessment is technical and statistical, understanding of validity by a non-specialist audience is essential as long as test results drive our educational…

  8. A valid licence

    NARCIS (Netherlands)

    Spoolder, H.A.M.; Ingenbleek, P.T.M.

    2010-01-01

    A valid licence Tuesday, April 20, 2010 Dr Hans Spoolder and Dr Paul Ingenbleek, of Wageningen University and Research Centres, share their thoughts on improving farm animal welfare in Europe At the presentation of the European Strategy 2020 on 3rd March, President Barroso emphasised the need for Eu

  9. Psychological stress during pregnancy and stillbirth: prospective study

    DEFF Research Database (Denmark)

    Wisborg, K.; Barklin, A.; Hedegaard, M.;

    2008-01-01

    OBJECTIVE: To study the association between psychological stress during pregnancy and stillbirth. DESIGN: Prospective follow-up study. SETTING: Aarhus University Hospital, Skejby, Denmark,1989-98. POPULATION: A total of 19 282 singleton pregnancies in women with valid information about psychologi......OBJECTIVE: To study the association between psychological stress during pregnancy and stillbirth. DESIGN: Prospective follow-up study. SETTING: Aarhus University Hospital, Skejby, Denmark,1989-98. POPULATION: A total of 19 282 singleton pregnancies in women with valid information about...... psychological stress during pregnancy. METHODS: Information about psychological stress during pregnancy was obtained from questionnaires and measured by the 12-item General Health Questionnaires (GHQ). A score was generated by the sum of all the answers, each contributing a value between 0 (low psychological...... stress) and 3 (high psychological stress). Women with an intermediate level of psychological stress (scores of 7-11) were considered the reference group. Scores of 0-6 were defined as a low level of psychological stress and scores of 12-36 as the highest level. The association between psychological...

  10. Self-Validating Thermocouple

    Science.gov (United States)

    Perotti, Jose M. (Inventor); Mata, Carlos T. (Inventor); Santiago, Josephine B. (Inventor); Vokrot, Peter (Inventor); Zavala, Carlos E. (Inventor); Burns, Bradley M. (Inventor)

    2010-01-01

    Self-Validating Thermocouple (SVT) Systems capable of detecting sensor probe open circuits, short circuits, and unnoticeable faults such as a probe debonding and probe degradation are useful in the measurement of temperatures. SVT Systems provide such capabilities by incorporating a heating or excitation element into the measuring junction of the thermocouple. By heating the measuring junction and observing the decay time for the detected DC voltage signal, it is possible to indicate whether the thermocouple is bonded or debonded. A change in the thermal transfer function of the thermocouple system causes a change in the rise and decay times of the thermocouple output. Incorporation of the excitation element does not interfere with normal thermocouple operation, thus further allowing traditional validation procedures as well.

  11. CIPS Validation Data Plan

    Energy Technology Data Exchange (ETDEWEB)

    Nam Dinh

    2012-03-01

    This report documents analysis, findings and recommendations resulted from a task 'CIPS Validation Data Plan (VDP)' formulated as an POR4 activity in the CASL VUQ Focus Area (FA), to develop a Validation Data Plan (VDP) for Crud-Induced Power Shift (CIPS) challenge problem, and provide guidance for the CIPS VDP implementation. The main reason and motivation for this task to be carried at this time in the VUQ FA is to bring together (i) knowledge of modern view and capability in VUQ, (ii) knowledge of physical processes that govern the CIPS, and (iii) knowledge of codes, models, and data available, used, potentially accessible, and/or being developed in CASL for CIPS prediction, to devise a practical VDP that effectively supports the CASL's mission in CIPS applications.

  12. Validating MEDIQUAL Constructs

    Science.gov (United States)

    Lee, Sang-Gun; Min, Jae H.

    In this paper, we validate MEDIQUAL constructs through the different media users in help desk service. In previous research, only two end-users' constructs were used: assurance and responsiveness. In this paper, we extend MEDIQUAL constructs to include reliability, empathy, assurance, tangibles, and responsiveness, which are based on the SERVQUAL theory. The results suggest that: 1) five MEDIQUAL constructs are validated through the factor analysis. That is, importance of the constructs have relatively high correlations between measures of the same construct using different methods and low correlations between measures of the constructs that are expected to differ; and 2) five MEDIQUAL constructs are statistically significant on media users' satisfaction in help desk service by regression analysis.

  13. Pain is associated with prospective memory dysfunction in multiple sclerosis.

    Science.gov (United States)

    Miller, Ashley K; Basso, Michael R; Candilis, Philip J; Combs, Dennis R; Woods, Steven Paul

    2014-01-01

    Prospective memory (PM) pertains to the execution of a future goal or behavior. Initial research implies that people with multiple sclerosis (MS) are apt to show impaired prospective memory for activities of daily living. Yet, PM impairment does not occur in all people with MS. Thus, some other variable besides disease status alone may contribute to PM dysfunction in people with MS. Chronic pain may be such a variable. Approximately 50-70% of people with MS experience significant pain, and such pain has been thought to diminish memory function. To investigate this possibility, 96 patients with MS and 29 healthy subjects were administered the Memory for Intentions Screening Test (MIST; Woods, S. P., Iudicello, J. E., Moran, L. M, Carey, C. L., Dawson, M. S., & Grant, I. (2008). HIV-associated prospective memory impairment increases risk of dependence in everyday functioning. Neuropsychology, 22, 110-117.), a well-validated measure of prospective memory, and the Medical Outcomes Study Pain Effects Scale (PES; Fischer, J. S., Rudick, R. A., Cutter, G. R., & Reingold, S. C. (1999). The multiple sclerosis functional composite measure (MSFC): An integrated approach to MS clinical outcome assessment. National MS Society Clinical Outcomes Assessment Task Force. Multiple Sclerosis, 5, 244-250.) to assess chronic pain. After controlling for demographic variables and disability severity, subjective pain accounted for significant variance in PM, particularly for time-based intentions over sustained delay periods. These data accord well with assertions that pain may degrade ability to remember new intentions and suggests that pain is associated with PM dysfunction in people with MS. PMID:25338929

  14. Validation and verification

    Institute of Scientific and Technical Information of China (English)

    J. Manickam

    2007-01-01

    @@ The challenge of developing a reliable predictive code with complicated scientific models, includes a process of verification and validation. The process of simulating a physics phenomenon generally includes:1. identifying the key features of the underlying physics;2. determining a suitable model set of equations;3. writing a computer code, which can solve the set of equations, and4. running the code and comparing the results with experimental data.

  15. Validating Animal Models

    OpenAIRE

    Nina Atanasova

    2015-01-01

    In this paper, I respond to the challenge raised against contemporary experimental neurobiology according to which the field is in a state of crisis because of the multiple experimental protocols employed in different laboratories and strengthening their reliability that presumably preclude the validity of neurobiological knowledge. I provide an alternative account of experimentation in neurobiology which makes sense of its experimental practices. I argue that maintaining a multiplicity of ex...

  16. Prospects of Single Tax Payers

    OpenAIRE

    Tofan Ivan M.

    2014-01-01

    The article speaks about problem aspects of taxation, which were set by the state for the single tax administering due to permanent and system changes in the tax legislation. It shows the necessity of search for alternative methods of administering in the process of taxation of single tax payers by fiscal services. The goal of the article is the study of prospects of further taxation of entrepreneurs – single tax payers on the basis of analysis of conditions and principles created by the stat...

  17. Renewable energy prospects for implementation

    CERN Document Server

    Jackson, Tim

    1993-01-01

    Renewable Energy: Prospects for Implementation contains papers that were originally commissioned by the journal Energy Policy for a series on renewable energy appearing between January 1991 to September 1992. In view of the fast-changing demands on conventional energy supply to meet environmental imperatives, it seemed timely to reproduce here a selection of those papers with a new introduction and a revised concluding chapter by the Editor of the series, Dr Tim Jackson, a research fellow with the Stockholm Environment Institute. The book is organized into four parts. The papers in Part I

  18. Atmospheric Neutrinos: Status and Prospects

    CERN Document Server

    Choubey, Sandhya

    2016-01-01

    We present an overview of the current status of neutrino oscillation studies at atmospheric neutrino experiments. While the current data gives some tentalising hints regarding the neutrino mass hierarchy, octant of $\\theta_{23}$ and $\\delta_{CP}$, the hints are not statistically significant. We summarise the sensitivity to these sub-dominant three-generation effects from the next-generation proposed atmospheric neutrino experiments. We next present the prospects of new physics searches such as non-standard interactions, sterile neutrinos and CPT violation studies at these experiments.

  19. Prospects for $K^+ \\to \\pi^+ \

    CERN Document Server

    Palladino, Vito

    2015-01-01

    The rare decays K+ -> p + n -n are excellent processes to make tests of new physics at the highest scale complementary to LHC thanks to their theoretically cleaness. The NA62 experiment at CERN SPS aims to collect of the order of 100 events in two years of data taking, keeping the background at the level of 10%. Part of the experimental apparatus has been commissioned during a technical run in 2012. The physics prospects and the status of the experiment will be reviewed after the commissioning run of 2014 and the data taking in 2015.

  20. SPEAKING ANXIETY SCALE FOR PROSPECTIVE TEACHERS: A VALIDITY AND RELIABILITY STUDY ÖĞRETMEN ADAYLARINA YÖNELİK KONUŞMA KAYGISI ÖLÇEĞİ: BİR GEÇERLİK VE GÜVENİRLİK ÇALIŞMASI

    Directory of Open Access Journals (Sweden)

    Oğuzhan SEVİM

    2012-06-01

    Full Text Available The purpose of this study is to develop the speaking anxiety scale that measures teacher candidates’ speaking anxiety. The sample of study is 338 teacher candidates who study in the social and natural sciences. The data of study were collected with speaking anxiety scale consisting of 35 items after a comprehensive literature review. It was made validity and reliability studies on the collected data and it was reached the last form of speaking anxiety scale consisting of 20 items. According to the analysis of data obtained from study, it was understood the scale developed is applicable. Bu çalışmada öğretmen adaylarının konuşma kaygılarının ölçülebilmesine yönelik bir konuşma kaygısı ölçeği geliştirmek amaçlanmıştır. Çalışma grubunu sosyal ve fen bilimleri alanlarında öğrenim gören 338 öğretmen adayı oluşturmaktadır. Araştırmanın verilerikapsamlı bir literatür taraması sonrasında hazırlanan 35 maddelik konuşma kaygısı ölçeğiyle toplanmıştır. Toplanan bu veriler üzerinde geçerlik ve güvenirlik çalışmaları yapılarak 20 maddeden oluşan konuşma kaygısı ölçeğinin son şekline ulaşılmıştır. Çalışmadan elde edilen verilerin analizine göre geliştirilen ölçeğin uygulanabilir olduğu sonucuna ulaşılmıştır.

  1. Prospective memory and chronic heart failure

    OpenAIRE

    Habota, Tina; Cameron, Jan; McLennan, Skye N; Ski, Chantal F; Thompson, David R; Peter G Rendell

    2013-01-01

    Background Patients with chronic heart failure (CHF) experience a number of debilitating symptoms, which impact on activities of daily living and result in poor quality of life. Prospective memory, which is defined as memory to carry out future intentions, has not been investigated in this group. However, emerging evidence suggests CHF patients have difficulties with cognitive processes related to prospective memory. Self-care, which partly relies on prospective memory, is essential in sympto...

  2. Preprint ARPPS Augmented Reality Pipeline Prospect System

    OpenAIRE

    Zhang, Xiaolei; Han, Yong; Hao, DongSheng; Lv, Zhihan

    2015-01-01

    This is the preprint version of our paper on ICONIP. Outdoor augmented reality geographic information system (ARGIS) is the hot application of augmented reality over recent years. This paper concludes the key solutions of ARGIS, designs the mobile augmented reality pipeline prospect system (ARPPS), and respectively realizes the machine vision based pipeline prospect system (MVBPPS) and the sensor based pipeline prospect system (SBPPS). With the MVBPPS's realization, this paper studies the neu...

  3. Prospective Memory Development Through Childhood into Adolescence

    OpenAIRE

    Bialek, Anna Katarzyna

    2009-01-01

    The present study looked at prospective memory development between 7-15 years of age (N=57). Past research has draw no coherent picture of prospective memory development due to variations in prospective memory tasks employed, motivation not being suppressed, time-based and event-based memory not being distinguished and time delay between intention formation and intention execution not being controlled. The present study aimed to overcome these issues and draw a more coherent picture of prospe...

  4. Validity of different pediatric early warning scores in the emergency department

    NARCIS (Netherlands)

    N. Seiger (Nienke); I.K. MacOnochie (Ian); R. Oostenbrink (Rianne); H.A. Moll (Henriëtte)

    2013-01-01

    textabstractObjective: Pediatric early warning scores (PEWS) are being advocated for use in the emergency department (ED). The goal of this study was to compare the validity of different PEWS in a pediatric ED. Methods: Ten different PEWS were evaluated in a large prospective cohort. We included chi

  5. Neonatal Facial Coding System for Assessing Postoperative Pain in Infants: Item Reduction is Valid and Feasible

    NARCIS (Netherlands)

    Peters, J.W.B.; Koot, H.M.; Grunau, R.E.; Boer, J. de; Druenen, M.J. van; Tibboel, D.; Duivenvoorden, H.J.

    2003-01-01

    Objective: The objectives of this study were to: (1) evaluate the validity of the Neonatal Facial Coding System (NFCS) for assessment of postoperative pain and (2) explore whether the number of NFCS facial actions could be reduced for assessing postoperative pain. Design: Prospective, observational

  6. Brief Assessment of Motor Function: Content Validity and Reliability of the Upper Extremity Gross Motor Scale

    Science.gov (United States)

    Cintas, Holly Lea; Parks, Rebecca; Don, Sarah; Gerber, Lynn

    2011-01-01

    Content validity and reliability of the Brief Assessment of Motor Function (BAMF) Upper Extremity Gross Motor Scale (UEGMS) were evaluated in this prospective, descriptive study. The UEGMS is one of five BAMF ordinal scales designed for quick documentation of gross, fine, and oral motor skill levels. Designed to be independent of age and…

  7. Work ethics: An Islamic prospective

    Directory of Open Access Journals (Sweden)

    Muhammad Shakil Ahmad

    2011-02-01

    Full Text Available Islamic principles completely cover all prospects of life including working in organization. The impact of management style used in an organization play an important role in employee commitment towards its work. This paper is an effort to explore impact of Islamic work ethic on human resource of organization including the prospective of work conflict, job satisfaction, job turn over, turnover intentions and organizational commitment. Data for current study was collected personally through questionnaires from 18 branches of seven banks of Pakistan who practices Islamic banking. In total, 150 Muslims employees were targeted as respondent of current study, while response rate was above 85%. Results show that there is significant impact of Islamic work ethics on organizational commitment, job satisfaction and rewards while Islamic work ethic has no significant relation with intention to quit job. Out of seven, only three hypotheses were fully supported, while two were partially supported, however number of rejected hypothesis were two. Islamic work ethics are source to built greater morale in employees resulting greater job satisfaction. Adopting Islamic work ethics improves organizational commitment, source of motivation as well as reduces the negative intentions of quitting job.

  8. A Role for Memory in Prospective Timing informs Timing in Prospective Memory

    OpenAIRE

    Waldum, Emily R.; Sahakyan, Lili

    2012-01-01

    Time-based prospective memory (TBPM) tasks require the estimation of time in passing – known as prospective timing. Prospective timing is said to depend on an attentionally-driven internal clock mechanism, and is thought to be unaffected by memory for interval information (for reviews see, Block, Hancock, & Zakay, 2010; Block & Zakay, 1997). A prospective timing task that required a verbal estimate following the entire interval (Experiment 1) and a TBPM task that required production of a targ...

  9. Checklist for the qualitative evaluation of clinical studies with particular focus on external validity and model validity

    Directory of Open Access Journals (Sweden)

    Vollmar Horst C

    2006-12-01

    Full Text Available Abstract Background It is often stated that external validity is not sufficiently considered in the assessment of clinical studies. Although tools for its evaluation have been established, there is a lack of awareness of their significance and application. In this article, a comprehensive checklist is presented addressing these relevant criteria. Methods The checklist was developed by listing the most commonly used assessment criteria for clinical studies. Additionally, specific lists for individual applications were included. The categories of biases of internal validity (selection, performance, attrition and detection bias correspond to structural, treatment-related and observational differences between the test and control groups. Analogously, we have extended these categories to address external validity and model validity, regarding similarity between the study population/conditions and the general population/conditions related to structure, treatment and observation. Results A checklist is presented, in which the evaluation criteria concerning external validity and model validity are systemised and transformed into a questionnaire format. Conclusion The checklist presented in this article can be applied to both planning and evaluating of clinical studies. We encourage the prospective user to modify the checklists according to the respective application and research question. The higher expenditure needed for the evaluation of clinical studies in systematic reviews is justified, particularly in the light of the influential nature of their conclusions on therapeutic decisions and the creation of clinical guidelines.

  10. Audit Validation Using Ontologies

    Directory of Open Access Journals (Sweden)

    Ion IVAN

    2015-01-01

    Full Text Available Requirements to increase quality audit processes in enterprises are defined. It substantiates the need for assessment and management audit processes using ontologies. Sets of rules, ways to assess the consistency of rules and behavior within the organization are defined. Using ontologies are obtained qualifications that assess the organization's audit. Elaboration of the audit reports is a perfect algorithm-based activity characterized by generality, determinism, reproducibility, accuracy and a well-established. The auditors obtain effective levels. Through ontologies obtain the audit calculated level. Because the audit report is qualitative structure of information and knowledge it is very hard to analyze and interpret by different groups of users (shareholders, managers or stakeholders. Developing ontology for audit reports validation will be a useful instrument for both auditors and report users. In this paper we propose an instrument for validation of audit reports contain a lot of keywords that calculates indicators, a lot of indicators for each key word there is an indicator, qualitative levels; interpreter who builds a table of indicators, levels of actual and calculated levels.

  11. Prospective Memory Training in older adults

    NARCIS (Netherlands)

    Schmidt, I.W.; Berg, I.J.; Deelman, B.G.

    2001-01-01

    This study evaluates the results of a training program for prospective remembering. The goal of the training was to improve prospective memory by associating cues from the retrieval situation with the to be remembered information. The training group consisted of 20 participants, aged between 45 and

  12. Prospective Biology Teachers' Understanding of Genetics Concepts.

    Science.gov (United States)

    Cakir, Mustafa; Crawford, Barbara

    The purpose of this study is to examine one possible source of misconceptions that are held by students of genetics--the teachers. Is there evidence to suggest that prospective biology teachers might have misconceptions about genetics and related concepts? If prospective biology teachers have misconceptions in genetics, how do these misconceptions…

  13. Prospective Elemantary Science Teachers' Epistemological Beliefs

    Science.gov (United States)

    Macaroglu Akgul, Esra; Oztuna Kaplan, Aysun

    2009-01-01

    This research study examined "prospective elementary science teachers' epistemological beliefs". Forty-nine prospective elementary science teachers participated into research. The research was designed in both quantitative and qualitative manner, within the context of "Special Methods in Science Teaching I" course. Participants' epistemological…

  14. Comparisons of Patient Demographics in Prospective Sports, Shoulder, and National Database Initiatives

    Science.gov (United States)

    Saltzman, Bryan M.; Cvetanovich, Gregory L.; Bohl, Daniel D.; Cole, Brian J.; Bach, Bernard R.; Romeo, Anthony A.

    2016-01-01

    Background: There has been increased emphasis in orthopaedics on high-quality prospective research to provide evidence-based treatment guidelines, particularly in sports medicine/shoulder surgery. The external validity of these studies has not been established, and the generalizability of the results to clinical practice in the United States is unknown. Hypothesis: Comparison of patient demographics in major prospective studies of arthroscopic sports and shoulder surgeries to patients undergoing the same procedures in the National Surgical Quality Improvement Program (NSQIP) database will show substantial differences to question the generalizability and external validity of those studies. Study Design: Cross-sectional study; Level of evidence, 3. Methods: This study utilized patients undergoing arthroscopic anterior cruciate ligament reconstruction (ACLR), meniscectomy (MX), rotator cuff repair (RCR), and shoulder stabilization (SS) from the NSQIP database (2005-2013). Two prospective studies (either randomized controlled trials or, in 1 case, a major cohort study) were identified for each of the 4 procedures for comparison. Demographic variables available for comparison in both the identified prospective studies and the NSQIP included age, sex, and body mass index (BMI). Results: From the NSQIP database, 5576 ACLR patients, 18,882 MX patients, 7282 RCR patients, and 993 SS patients were identified. The comparison clinical studies included cohort sizes as follows: ACLR, n = 121 and 2683; MX, n = 146 and 330; RCR, n = 90 and 103; SS, n = 88 and 196. Age differed significantly between the NSQIP and the patients in 6 of the 8 prospective clinical studies. Sex differed significantly between the NSQIP and the patients in 7 of the 8 prospective clinical studies. BMI differed significantly between the NSQIP and the patients of all 4 of the prospective clinical studies that reported this demographic variable. Conclusion: Significant differences exist for patient age, sex

  15. Changing Behavior by Memory Aids: A Social Psychological Model of Prospective Memory and Habit Development Tested with Dynamic Field Data

    Science.gov (United States)

    Tobias, Robert

    2009-01-01

    This article presents a social psychological model of prospective memory and habit development. The model is based on relevant research literature, and its dynamics were investigated by computer simulations. Time-series data from a behavior-change campaign in Cuba were used for calibration and validation of the model. The model scored well in…

  16. Prospects in Analytical Atomic Spectrometry

    CERN Document Server

    Bolshakov, A A; Nemets, V M

    2006-01-01

    Tendencies in five main branches of atomic spectrometry (absorption, emission, mass, fluorescence and ionization spectrometry) are considered. The first three techniques are the most widespread and universal, with the best sensitivity attributed to atomic mass spectrometry. In the direct elemental analysis of solid samples, the leading roles are now conquered by laser-induced breakdown and laser ablation mass spectrometry, and the related techniques with transfer of the laser ablation products into inductively-coupled plasma. Advances in design of diode lasers and optical parametric oscillators promote developments in fluorescence and ionization spectrometry and also in absorption techniques where uses of optical cavities for increased effective absorption pathlength are expected to expand. Prospects for analytical instrumentation are seen in higher productivity, portability, miniaturization, incorporation of advanced software, automated sample preparation and transition to the multifunctional modular archite...

  17. Theoretical Prospects for B Physics

    CERN Document Server

    Fleischer, Robert

    2015-01-01

    The exploration of B-meson decays has reached an unprecedented level of sophistication, with a phase of even much higher precision ahead of us thanks to run 2 of the LHC and the future era of Belle II and the LHCb upgrade. For many processes, the theoretical challenge in the quest to reveal possible footprints of physics beyond the Standard Model will be the control of uncertainties from strong interactions. After a brief discussion of the global picture emerging from the LHC data, I will focus on the theoretical prospects and challenges for benchmark B decays to search for new sources of CP violation, and highlight future opportunities to probe the Standard Model with strongly suppressed rare B decays.

  18. Status and development of uranium prospection methods

    International Nuclear Information System (INIS)

    In radiometric prospection, gamma measuring equipment is widely used. Simple instruments, so-called scintillometers, can only measure total radiation while spectrometers permit separate measurements of uranium, thorium, or calcium via daughter products of their decay chains. Depending on the target investigated, airborne, carborne, or footborne methods are employed. In radon prospection the gaseous decay product radon is measured as a sign of hidden uranium enrichment in ground air or water from springs. Due to its high solubility, uranium is well suited for geochemical prospection where uranium concentrations in bodies of water, river sediments, soil and rock types are determined. There is a trend in uranium prospection towards the discovery of hidden orifications. Novel techniques, e.g. airborne geochemistry, isotope chemistry, tracer element measurement, etc. are being tested with a view to their suitability for uranium prospection. (orig./HP) 891 HP/orig.- 892 MKO

  19. Validation of EMP bounds

    Energy Technology Data Exchange (ETDEWEB)

    Warne, L.K.; Merewether, K.O.; Chen, K.C.; Jorgenson, R.E.; Morris, M.E.; Solberg, J.E.; Lewis, J.G. [Sandia National Labs., Albuquerque, NM (United States); Derr, W. [Derr Enterprises, Albuquerque, NM (United States)

    1996-07-01

    Test data on canonical weapon-like fixtures are used to validate previously developed analytical bounding results. The test fixtures were constructed to simulate (but be slightly worse than) weapon ports of entry but have known geometries (and electrical points of contact). The exterior of the test fixtures exhibited exterior resonant enhancement of the incident fields at the ports of entry with magnitudes equal to those of weapon geometries. The interior consisted of loaded transmission lines adjusted to maximize received energy or voltage but incorporating practical weapon geometrical constraints. New analytical results are also presented for bounding the energies associated with multiple bolt joints and for bounding the exterior resonant enhancement of the exciting fields.

  20. Validation of community robustness

    CERN Document Server

    Carissimo, Annamaria; Defeis, Italia

    2016-01-01

    The large amount of work on community detection and its applications leaves unaddressed one important question: the statistical validation of the results. In this paper we present a methodology able to clearly detect if the community structure found by some algorithms is statistically significant or is a result of chance, merely due to edge positions in the network. Given a community detection method and a network of interest, our proposal examines the stability of the partition recovered against random perturbations of the original graph structure. To address this issue, we specify a perturbation strategy and a null model to build a set of procedures based on a special measure of clustering distance, namely Variation of Information, using tools set up for functional data analysis. The procedures determine whether the obtained clustering departs significantly from the null model. This strongly supports the robustness against perturbation of the algorithm used to identify the community structure. We show the r...

  1. Validated dynamic flow model

    DEFF Research Database (Denmark)

    Knudsen, Torben

    2011-01-01

    The purpose with this deliverable 2.5 is to use fresh experimental data for validation and selection of a flow model to be used for control design in WP3-4. Initially the idea was to investigate the models developed in WP2. However, in the project it was agreed to include and focus on a additive...... model structure suggested by University of Lund the WP4 leader. This particular model structure has the advantages that it fits better into the control design frame work used by WP3-4 compared to the model structures previously developed in WP2. The different model structures are first summarised...... model turns out not to be useful for prediction of the flow. Moreover, standard Box Jenkins model structures and multiple output auto regressive models proves to be superior as they can give useful predictions of the flow....

  2. Major dietary patterns and risk of frailty in older adults: a prospective cohort study

    OpenAIRE

    León-Muñoz, Luz M.; García-Esquinas, Esther; López-García, Esther; Banegas, José R; Rodríguez-Artalejo, Fernando

    2015-01-01

    Background There is emerging evidence of the role of certain nutrients as risk factors for frailty. However, people eat food, rather than nutrients, and no previous study has examined the association between dietary patterns empirically derived from food consumption and the risk of frailty in older adults. Methods This is a prospective cohort study of 1,872 non-institutionalized individuals aged ≥60 years recruited between 2008 and 2010. At baseline, food consumption was obtained with a valid...

  3. Reliability and validity of Leicester Cough Questionnaire Korean version.

    Science.gov (United States)

    Han, Jong-Min; Jung, In-Chul; Kang, Weechang; Kim, Seung-Su; Yeo, Yoon; Park, Yang-Chun

    2014-06-01

    The Leicester Cough Questionnaire (LCQ) is a self-administered questionnaire developed in England and validated for reliability. We developed a Korean translation of this questionnaire by applying a sequential forward and backward translation approach. The purpose of this study is to validate the Korean version of the LCQ (LCQ-K) in Korean patients with chronic cough. A multicenter prospective study was undertaken with 100 chronic cough patients who consented to participate in the study. The LCQ-K includes eight physical items, seven psychological items, and four social items. Visual analog scale (VAS) of cough, Borg Cough Scale (BCS), and Short Form-36 (SF-36) were used as external comparators. Participants included 52 women and 48 men with ages ranging from 18 years to 69 years. The concurrent validity comparing LCQ-K to VAS, BCS, and SF-36 yielded statistically significant Pearson correlation coefficients. The LCQ-K showed good reliability in three domains, with Cronbach's α coefficients ranging from 0.84 to 0.87 (total: 0.91). Test-retest reliability was investigated with single measure intraclass correlation coefficients, which were found to be practically and statistically significant (p = 0.005). Responsiveness was validated by effective size ranging from 1.16 to 1.40 in each domain. LCQ-K is a reliable, valid, and responsive disease-specific questionnaire for assessing symptoms and quality of life of Korean patients with chronic cough. PMID:24906688

  4. Development and initial validation of the Seated Posture Scale

    Directory of Open Access Journals (Sweden)

    Lelia Barks, PhD, ARNP

    2015-06-01

    Full Text Available Literature shows that some health outcomes (e.g., eating, breathing, and speaking are directly related to posture. Evidence of outcomes mediated by wheelchair seated posture is limited to interface pressure, physical function, and wheelchair skills and safety. This study’s purpose was to develop and validate a rapid, low-burden, paper-pencil assessment of wheelchair seated posture for research use and to test feasibility of its use with a sample of older adults. We used a prospective design and a convenience sample of older adults who were receiving rehabilitation services in a community living center. Forty-nine older wheelchair users participated. Main measures were the Seated Posture Scale (SPS, Modified Ashworth Scale, Barthel Index, Visual Descriptor Scale, scale-content validity index (S-CVI, Cronbach alpha, and test-retest reliability. Rating by six experts yielded the overall content validity score (S-CVI of 0.744. Total SPS score correlated positively with physical function (Barthel Index, r = 0.46, p < 0.001 and negatively with muscle tone (Modified Ashworth Scale, r = –0.44, p = 0.001, supporting SPS construct validity. Internal consistency was 0.66 (Cronbach alpha. Test-retest reliability yielded Pearson product-moment correlations of 0.89 to 0.99. We conclude that the SPS has sufficient preliminary validity and reliability to support its use as an evaluation of wheelchair seated posture in outcomes research.

  5. Remembering about Intended Actions: review of Studies on Prospective Memory.

    OpenAIRE

    Albiński, Rafał

    2009-01-01

    The aim of the article is to acquaint the reader with the subject of prospective memory, especially in its event-based form. Definition of prospective memory is presented in the text along with discussion concerning the place of prospective memory in the broadly understood memory research area. Critical features of prospective tasks and two types of processes (automatic and controlled) mediating prospective memory are described. Also presented is the multi-process framework of prospective mem...

  6. Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE)

    OpenAIRE

    Fox, Keith A. A.; Dabbous, Omar H; Robert J. Goldberg; Pieper, Karen S.; Eagle, Kim A.; Werf, Frans; Avezum, Alvaro; Goodman, Shaun G; Flather, Marcus D; Frederick A Anderson; Granger, Christopher B

    2006-01-01

    OBJECTIVE: To develop a clinical risk prediction tool for estimating the cumulative six month risk of death and death or myocardial infarction to facilitate triage and management of patients with acute coronary syndrome.DESIGN: Prospective multinational observational study in which we used multivariable regression to develop a final predictive model, with prospective and external validation.SETTING: Ninety four hospitals in 14 countries in Europe, North and South America, Australia, and New Z...

  7. Prospect theory in the health domain: a quantitative assessment.

    Science.gov (United States)

    Attema, Arthur E; Brouwer, Werner B F; I'Haridon, Olivier

    2013-12-01

    It is well-known that expected utility (EU) has empirical deficiencies. Cumulative prospect theory (CPT) has developed as an alternative with more descriptive validity. However, CPT's full function had not yet been quantified in the health domain. This paper is therefore the first to simultaneously measure utility of life duration, probability weighting, and loss aversion in this domain. We observe loss aversion and risk aversion for gains and losses, which for gains can be explained by probabilistic pessimism. Utility for gains is almost linear. For losses, we find less weighting of probability 1/2 and concave utility. This contrasts with the common finding of convex utility for monetary losses. However, CPT was proposed to explain choices among lotteries involving monetary outcomes. Life years are arguably very different from monetary outcomes and need not generate convex utility for losses. Moreover, utility of life duration reflects discounting, causing concave utility. PMID:24103499

  8. Prospect theory in the health domain: a quantitative assessment.

    Science.gov (United States)

    Attema, Arthur E; Brouwer, Werner B F; I'Haridon, Olivier

    2013-12-01

    It is well-known that expected utility (EU) has empirical deficiencies. Cumulative prospect theory (CPT) has developed as an alternative with more descriptive validity. However, CPT's full function had not yet been quantified in the health domain. This paper is therefore the first to simultaneously measure utility of life duration, probability weighting, and loss aversion in this domain. We observe loss aversion and risk aversion for gains and losses, which for gains can be explained by probabilistic pessimism. Utility for gains is almost linear. For losses, we find less weighting of probability 1/2 and concave utility. This contrasts with the common finding of convex utility for monetary losses. However, CPT was proposed to explain choices among lotteries involving monetary outcomes. Life years are arguably very different from monetary outcomes and need not generate convex utility for losses. Moreover, utility of life duration reflects discounting, causing concave utility.

  9. Metaphoric Perceptions of Prospective Teachers Regarding the Concept of Curriculum

    Directory of Open Access Journals (Sweden)

    Soner Mehmet ÖZDEMİR

    2012-07-01

    Full Text Available This study aims to determine perceptions of prospective teachers regarding the concept of curriculum through their metaphors. The sample consisted of 302 prospective teachers enrolled in various departments of the Faculty of Education, Kırıkkale University, Turkey. Open-ended questions were used to collect data and qualitative procedures were followed to analyze the data. The results of the study revealed that participants develop a total of 148 valid metaphors clustered under 8 different categories, which were; “curriculum as an organization/constructed mechanism/regular and hierarchical operation”, “curriculum as a guide”, “curriculum as a process”, “curriculum as a tool to find a solution”, “curriculum as a design created according to a rule, principle or aim”, “curriculum as an inevitable part”, “curriculum as a pattern to shape individuals”, “curriculum as a continuously changing concept”. The metaphors mostly developed by participants were “guide/advisor”, “system”, “a plan or project of a building”, “human life” and “map/roadmap”.

  10. Stellar opacity validations

    Science.gov (United States)

    Le Pennec, M.; Turck-Chièze, S.; Ribeyre, X.; Ducret, J. E.

    2014-12-01

    This paper focuses on the radiative transfer in stars where opacities seem to raise problems : β-Cephei and solar-type stars. We first concentrate on the iron bump (log T = 5.25), responsible for β-Cephei pulsations through the κ-mechanism. To discriminate between the different opacity calculations used to predict their oscillations, new well-qualified calculations are used and compared to OP calculations. In parallel with this theoretical work, an experiment has been conducted at LULI 2000 in 2011 on iron and nickel. We show that this extended study pushes for the revision of the tables in the conditions corresponding to the iron bump region, at least for nickel. We will then deal with the Sun case for which we are preparing an opacity experiment on a high-energy laser, in some conditions of the radiative zone (T = [2 - 15 ×10^{6} K] and ρ = [0.2 - 150 g/cm^{3}]). To reach these high temperatures and densities at LTE and validate or not plasma effects and line widths, we are exploring an approach called the Double Ablation Front, driven by plasma radiative effects. The 1D simulations performed with the code CHIC show that with this technique, we could reach conditions equivalent to the conditions of half of the solar radiative zone.

  11. Antiaging therapy: a prospective hypothesis

    Directory of Open Access Journals (Sweden)

    Shahidi Bonjar MR

    2015-01-01

    Full Text Available Mohammad Rashid Shahidi Bonjar,1 Leyla Shahidi Bonjar2 1School of Dentistry, Kerman University of Medical Sciences, Kerman Iran; 2Department of Pharmacology, College of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran Abstract: This hypothesis proposes a new prospective approach to slow the aging process in older humans. The hypothesis could lead to developing new treatments for age-related illnesses and help humans to live longer. This hypothesis has no previous documentation in scientific media and has no protocol. Scientists have presented evidence that systemic aging is influenced by peculiar molecules in the blood. Researchers at Albert Einstein College of Medicine, New York, and Harvard University in Cambridge discovered elevated titer of aging-related molecules (ARMs in blood, which trigger cascade of aging process in mice; they also indicated that the process can be reduced or even reversed. By inhibiting the production of ARMs, they could reduce age-related cognitive and physical declines. The present hypothesis offers a new approach to translate these findings into medical treatment: extracorporeal adjustment of ARMs would lead to slower rates of aging. A prospective “antiaging blood filtration column” (AABFC is a nanotechnological device that would fulfill the central role in this approach. An AABFC would set a near-youth homeostatic titer of ARMs in the blood. In this regard, the AABFC immobilizes ARMs from the blood while blood passes through the column. The AABFC harbors antibodies against ARMs. ARM antibodies would be conjugated irreversibly to ARMs on contact surfaces of the reaction platforms inside the AABFC till near-youth homeostasis is attained. The treatment is performed with the aid of a blood-circulating pump. Similar to a renal dialysis machine, blood would circulate from the body to the AABFC and from there back to the body in a closed circuit until ARMs were sufficiently depleted from the blood. The

  12. Validation of an organizational communication climate assessment toolkit.

    Science.gov (United States)

    Wynia, Matthew K; Johnson, Megan; McCoy, Thomas P; Griffin, Leah Passmore; Osborn, Chandra Y

    2010-01-01

    Effective communication is critical to providing quality health care and can be affected by a number of modifiable organizational factors. The authors performed a prospective multisite validation study of an organizational communication climate assessment tool in 13 geographically and ethnically diverse health care organizations. Communication climate was measured across 9 discrete domains. Patient and staff surveys with matched items in each domain were developed using a national consensus process, which then underwent psychometric field testing and assessment of domain coherence. The authors found meaningful within-site and between-site performance score variability in all domains. In multivariable models, most communication domains were significant predictors of patient-reported quality of care and trust. The authors conclude that these assessment tools provide a valid empirical assessment of organizational communication climate in 9 domains. Assessment results may be useful to track organizational performance, to benchmark, and to inform tailored quality improvement interventions.

  13. Enhanced XML Validation Using SRML

    Directory of Open Access Journals (Sweden)

    Miklos Kalman

    2013-10-01

    Full Text Available Data validation is becoming more and more important with the ever-growing amount of data being consumed and transmitted by systems over the Internet. It is important to ensure that the data being sent is valid as it may contain entry errors, which may be consumed by different systems causing further errors. XML has become the defacto standard for data transfer. The XML Schema Definition language (XSD was created to help XML structural validation and provide a schema for data type restrictions, however it does not allow for more complex situations. In this article we introduce a way to provide rule based XML validation and correction through the extension and improvement of our SRML metalanguage. We also explore the option of applying it in a database as a trigger for CRUD operations allowing more granular dataset validation on an atomic level allowing for more complex dataset record validation rules.

  14. Validation scheme for diagnostic tests

    International Nuclear Information System (INIS)

    The aim was to develop a scheme for the validation of assays developed in the research laboratory for the successful transfer and implementation in the diagnostic laboratory. Although logistically, temporally and economically challenging, proper validation minimizes the chance of failure and increases the possibility of successful transfer and implementation in the diagnostic laboratory. A properly validated assay, which includes good design, good quality control and good documentation, reduces the chances of liability and increases confidence in the assay both nationally and internationally

  15. SHIELD verification and validation report

    Energy Technology Data Exchange (ETDEWEB)

    Boman, C.

    1992-02-01

    This document outlines the verification and validation effort for the SHIELD, SHLDED, GEDIT, GENPRT, FIPROD, FPCALC, and PROCES modules of the SHIELD system code. Along with its predecessors, SHIELD has been in use at the Savannah River Site (SRS) for more than ten years. During this time the code has been extensively tested and a variety of validation documents have been issued. The primary function of this report is to specify the features and capabilities for which SHIELD is to be considered validated, and to reference the documents that establish the validation.

  16. Assessing prospects for small reactors

    International Nuclear Information System (INIS)

    The use of nuclear power plants, like that of many other technologies, has been characterized by substantial growth in spread, numbers, equipment and plant sizes, with economies of scale generally favouring the large plants. Small and medium sized nuclear power plants, or SMPRs, are generally understood to be plants below the sizes being exploited commercially in industrialized countries. Such plants could be more readily adapted to smaller electric grids, particularly in developing countries, fulfilling requirements of low load growth, or serve remote locations or special purposes. The SMPR range is currently understood as the 200 to 500 megawatt (MWe) size for the generation of electricity and sometimes smaller for process-steam and/or low-temperature heat supply. For statistical purposes a size limit of 600 MWe has been in use by IAEA for some years. By this criterion some 140 nuclear power plants, or more than one-third of the world total, could be considered SMPRs. However, most of them are rather old vintage. Prospects are assessed under headings: indications of revived interest; today's SMPR supply situation; evolving IAEA programme - new study; market indications; economic competitiveness and financing aspects. (author)

  17. Status and prospects for reprocessing

    International Nuclear Information System (INIS)

    Following the formation of United Reprocessors (U.R.G.) in 1976 by British Nuclear Fuels Limited (B.N.F.L.) in the United Kingdom, the Commissariat a l'Energie Atomique (C.E.A.) in France and K.E.W.A. Kernbrennstoff-Wiederaufarbeitungs-Gesellschaft MBH (K.E.W.A.) in Germany, collaboration is now well established for the marketing of their reprocessing services for irradiated oxide fuel from thermal reactors. In addition collaboration in the continued evolution of the technology has progressed and an extensive research and development programme has been established, the results of which are exchanged between the shareholders. During 1976 the U.K. Government has given approval to B.N.F.L. to sign further contracts with foreign customers, subject to certain conditions. In France, the fuel cycle activities of the C.E.A. have been vested in a new company (Compagnie Generale Des Matieres Nucleaires (C.O.G.E.M.A.)) and their La Hague plant has commenced reprocessing operations on irradiated oxide fuel. In Germany, an agreement has been signed between K.E.W.A. and P.W.K. for the pre-project study for the proposed German plant. Against this background this paper reviews the present status of reprocessing by the shareholders of U.R.G. and the prospects for reprocessing

  18. Dual pathways to prospective remembering

    Science.gov (United States)

    McDaniel, Mark A.; Umanath, Sharda; Einstein, Gilles O.; Waldum, Emily R.

    2015-01-01

    According to the multiprocess framework (McDaniel and Einstein, 2000), the cognitive system can support prospective memory (PM) retrieval through two general pathways. One pathway depends on top–down attentional control processes that maintain activation of the intention and/or monitor the environment for the triggering or target cues that indicate that the intention should be executed. A second pathway depends on (bottom–up) spontaneous retrieval processes, processes that are often triggered by a PM target cue; critically, spontaneous retrieval is assumed not to require monitoring or active maintenance of the intention. Given demand characteristics associated with experimental settings, however, participants are often inclined to monitor, thereby potentially masking discovery of bottom–up spontaneous retrieval processes. In this article, we discuss parameters of laboratory PM paradigms to discourage monitoring and review recent behavioral evidence from such paradigms that implicate spontaneous retrieval in PM. We then re-examine the neuro-imaging evidence from the lens of the multiprocess framework and suggest some critical modifications to existing neuro-cognitive interpretations of the neuro-imaging results. These modifications illuminate possible directions and refinements for further neuro-imaging investigations of PM. PMID:26236213

  19. Dual Pathways to Prospective Remembering

    Directory of Open Access Journals (Sweden)

    Mark A Mcdaniel

    2015-07-01

    Full Text Available According to the multiprocess framework (McDaniel & Einstein, 2000, the cognitive system can support prospective memory (PM retrieval through two general pathways. One pathway depends on top-down attentional control processes that maintain activation of the intention and/or monitor the environment for the triggering or target cues that indicate that the intention should be executed. A second pathway depends on (bottom-up spontaneous retrieval processes, processes that are often triggered by a PM target cue; critically spontaneous retrieval is assumed to not require monitoring or active maintenance of the intention. Given demand characteristics associated with experimental settings, however, participants are often inclined to monitor, thereby potentially masking discovery of bottom-up spontaneous retrieval processes. In this article, we discuss parameters of laboratory PM paradigms to discourage monitoring and review recent behavioral evidence from such paradigms that implicate spontaneous retrieval in PM. We then re-examine the neuro-imaging evidence from the lens of the multiprocess framework and suggest some critical modifications to existing neuro-cognitive interpretations of the neuro-imaging results. These modifications illuminate possible directions and refinements for further neuro-imaging investigations of PM.

  20. North American tidal power prospects

    Science.gov (United States)

    Wayne, W. W., Jr.

    1981-07-01

    Prospects for North American tidal power electrical generation are reviewed. Studies by the US Army Corps of Engineers of 90 possible generation schemes in Cobscook Bay, ME, indicated that maximum power generation rather than dependable capacity was the most economic method. Construction cost estimates for 15 MW bulb units in a single effect mode from basin to the sea are provided; five projects were considered ranging from 110-160 MW. Additional tidal power installations are examined for: Half-Moon Cove, ME (12 MW, 18 ft tide); Cook Inlet, AK, which is shown to pose severe environmental and engineering problems due to fish migration, earthquake hazards, and 300 ft deep silt deposits; and the Bay of Fundy, Canada. This last has a 17.8 MW plant under construction in a 29 ft maximum tide area. Other tidal projects of the Maritime Provinces are reviewed, and it is noted that previous economic evaluations based on an oil price of $16/barrel are in need of revision.

  1. Prospects of geothermal resource exploitation

    International Nuclear Information System (INIS)

    The use of geothermal energy to generate electricity has only occurred during the past 50 years by drilling wells in aquifers close to magmas and producing either dry steam or hot water. The world's production of electricity from geothermal energy is over 6000 MWe and is still growing. The direct use of geothermal energy for major urban communities has been developed recently by exploitation of aquifers in sedimentary basins under large towns. Scaling up the extraction of heat implies the exploitation of larger and better located fields requiring an appropriate method of extraction; the objective of present attempts in USA, Japan and Europe is to create heat exchangers by the circulation of water between several deep wells. Two field categories are considered: the extension of classical geothermal fields beyond the aquifer areas, and areas favoured by both a high geothermal gradient, fractures inducing a natural permeability at large scale, and good commercial prospects (such as in the Rhenan Graben). Hot dry rocks concept has gained a large interest. 1 fig., 5 tabs., 11 refs

  2. Prospects of Single Tax Payers

    Directory of Open Access Journals (Sweden)

    Tofan Ivan M.

    2014-03-01

    Full Text Available The article speaks about problem aspects of taxation, which were set by the state for the single tax administering due to permanent and system changes in the tax legislation. It shows the necessity of search for alternative methods of administering in the process of taxation of single tax payers by fiscal services. The goal of the article is the study of prospects of further taxation of entrepreneurs – single tax payers on the basis of analysis of conditions and principles created by the state for the business. The article used methods of system analysis, comparison, forecasting and modelling. It analyses the process of evolution of the simplified taxation system, accounting and reporting from the moment of its adoption until today. The article presents the structure of the quantitative composition of single tax payers depending on the selected groups. It marks out and characterises administrative and fiscal factors that do not facilitate further development of entrepreneurship in Ukraine. In the result of the conducted studies the article outlines problem aspects of organisation of taxation of the small business and offers specific and real ways of their overcoming or partial solution.

  3. Experimental validation of UTDefect

    International Nuclear Information System (INIS)

    This study reports on conducted experiments and computer simulations of ultrasonic nondestructive testing (NDT). Experiments and simulations are compared with the purpose of validating the simulation program UTDefect. UTDefect simulates ultrasonic NDT of cracks and some other defects in isotropic and homogeneous materials. Simulations for the detection of surface breaking cracks are compared with experiments in pulse-echo mode on surface breaking cracks in carbon steel plates. The echo dynamics are plotted and compared with the simulations. The experiments are performed on a plate with thickness 36 mm and the crack depths are 7.2 mm and 18 mm. L- and T-probes with frequency 1, 2 and 4 MHz and angels 45, 60 and 70 deg are used. In most cases the probe and the crack is on opposite sides of the plate, but in some cases they are on the same side. Several cracks are scanned from two directions. In total 53 experiments are reported for 33 different combinations. Generally the simulations agree well with the experiments and UTDefect is shown to be able to, within certain limits, perform simulations that are close to experiments. It may be concluded that: For corner echoes the eight 45 deg cases and the eight 60 deg cases show good agreement between experiments and UTDefect, especially for the 7.2 mm crack. The amplitudes differ more for some cases where the defect is close to the probe and for the corner of the 18 mm crack. For the two 70 deg cases there are too few experimental values to compare the curve shapes, but the amplitudes do not differ too much. The tip diffraction echoes also agree well in general. For some cases, where the defect is close to the probe, the amplitudes differ more than 10-15 dB, but for all but two cases the difference in amplitude is less than 7 dB. 6 refs

  4. The validation of a diagnostic rule for gout without joint fluid analysis: a prospective study

    NARCIS (Netherlands)

    Kienhorst, L.B.; Janssens, H.J.; Fransen, J.; Janssen, M

    2015-01-01

    OBJECTIVE: The gold standard for diagnosing gout is the identification of MSU crystals in joint fluid. In secondary care, the facilities or expertise to analyse joint fluid are not always available and gout is diagnosed clinically. To improve the predictive value of the clinical diagnosis of gout in

  5. The measurement of instrumental ADL: content validity and construct validity

    DEFF Research Database (Denmark)

    Avlund, K; Schultz-Larsen, K; Kreiner, S

    1993-01-01

    A new measure of Instrumental Activities of Daily Living (IADL), which is able to discriminate among the large group of elderly who do not depend on help, was tested for content validity and construct validity. Most assessments of functional ability include Physical ADL (PADL) and Instrumental ADL....... The measure of Instrumental ADL included 30 activities in relation to tiredness and reduced speed. Construct validity was tested by the Rasch model for item analysis; internal validity was specifically addressed by assessing the homogeneity of items under different conditions. The Rasch item analysis of IADL...... showed that 14 items could be combined into two qualitatively different additive scales. The IADL-measure complies with demands for content validity, distinguishes between what the elderly actually do, and what they are capable of doing, and is a good discriminator among the group of elderly persons who...

  6. Hypnosis Attenuates Executive Cost of Prospective Memory.

    Science.gov (United States)

    Demeter, Gyula; Szendi, István; Juhász, Marianna; Kovács, Zoltán Ambrus; Boncz, István; Keresztes, Attila; Pajkossy, Péter; Racsmány, Mihály

    2016-01-01

    Prospective memory is the ability to formulate and carry out actions at the appropriate time or in the appropriate context. This study aimed to identify the effect of hypnosis on prospective memory performance and to analyze the involvement of executive control processes in intention realization in a hypnotically altered state of consciousness. In 1 experiment, manipulating hypnotic instruction in a within-subject fashion, the authors explored the event-based prospective memory performance of 23 volunteers in 3 conditions: baseline, expectation, and execution. The primary result was that executing prospective memory responses, at the same accuracy rate, produced a significantly lower cost of ongoing responses in terms of response latency in the hypnotic state than in wake condition. PMID:26894423

  7. Haematuria analysed--a prospective study.

    OpenAIRE

    Gillatt, D A; O'Reilly, P H

    1987-01-01

    One hundred consecutive cases of haematuria were studied prospectively. The results showed a high proportion (52%) of serious urological disease. The need for thorough investigation of even minor degrees of haematuria is again emphasized.

  8. Nuclear radiation cleanup and uranium prospecting

    Energy Technology Data Exchange (ETDEWEB)

    Mariella, Jr., Raymond P.; Dardenne, Yves M.

    2016-02-02

    Apparatus, systems, and methods for nuclear radiation cleanup and uranium prospecting include the steps of identifying an area; collecting samples; sample preparation; identification, assay, and analysis; and relating the samples to the area.

  9. Caolines Program. N1 area prospective soundings

    International Nuclear Information System (INIS)

    This work is about The Caolines program. After several stages was designed a network of drilling to be developed in prospective areas. The support of this network was a geological cartography performed in a devonian region.

  10. Physics prospects at a linear + - collider

    Indian Academy of Sciences (India)

    Saurabh D Rindani

    2006-10-01

    The talk described the prospects of studying standard model parameters as well as scenarios beyond the standard model, like the minimal supersymmetric standard model, theories with extra dimensions and theories with extra neutral gauge bosons, at a future linear + - collider.

  11. Hospital Outpatient Prospective Payment System (OPPS) Lim...

    Data.gov (United States)

    U.S. Department of Health & Human Services — Hospital Outpatient Prospective Payment System (OPPS) Limited Data Set This file contains select claim level data and is derived from 2010 hospital outpatient PPS...

  12. Vision Trouble Can Dim Life's Prospects

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_160136.html Vision Trouble Can Dim Life's Prospects But it's not ... THURSDAY, July 28, 2016 (HealthDay News) -- People with vision problems may face a higher risk of unemployment, ...

  13. Analyzing Ukraine's prospects for NATO membership

    OpenAIRE

    Young, Derek W.

    2008-01-01

    Ukraine has a resume of achievements in its relations with NATO since 1991. However, at the 2008 Bucharest Summit, the NATO Allies chose not to offer Ukraine a Membership Action Plan. This thesis examines Ukraine's prospects for NATO membership, and investigates the hypothesis that Ukraine's membership aspirations are most affected by two sets of independent variables -- internal and external. The two key internal variables that affect the prospects for Ukraine's accession to NATO are public ...

  14. How important is importance for prospective memory?

    OpenAIRE

    Stefan eWalter; Beat eMeier

    2014-01-01

    Forgetting to carry out an intention as planned can have serious consequences in everyday life. People sometimes even forget intentions that they consider as very important. Here, we review the literature on the impact of importance on prospective memory performance. We highlight different methods used to manipulate the importance of a prospective memory task such as providing rewards, importance relative to other ongoing activities, absolute importance, and providing social motives. Moreover...

  15. Uranium prospection methods illustrated with examples

    International Nuclear Information System (INIS)

    Uranium exploration methods are briefly reviewed: aerial (radiometric, spectrometric), surface (mapping, radiometric, geophysical, geochemical), sub-surface (well logging, boring) and mining methods in the different steps of a mine project: preliminary studies, general prospecting, detailed prospecting deposit area and deposit estimation. Choice of methods depends strongly on geographic and geologic environment. Three examples are given concerning: an intragranitic deposit Limousin (France), a deposit spatially related to a discordance Athabasca (Canada) and a sedimentary deposit Manyingee (Western Australia)

  16. Fairness in prospective payment: a clustering approach.

    OpenAIRE

    Stefos, T; LaVallee, N; Holden, F

    1992-01-01

    Problems of fairness in prospective payment have existed since the inception of this regulatory method in the early 1980s. While prospective payment ostensibly has sought to reward efficient producers and provide disincentives for inefficient producers of health care, many hospitals have been penalized financially as a consequence of facing systematic factors beyond their control. This article defines homogenous peer groups of Department of Veterans Affairs providers for the purpose of establ...

  17. Training course on radiometric prospecting techniques

    International Nuclear Information System (INIS)

    A training course on radiometric prospecting techniques was presented by the Atomic Energy Board in collaboration with the South African Geophysical Association and the Geological Society of South Africa. Various aspects related to uranium prospecting were discussed e.g. the uranium supply and demand position, the basic physics of radioactivity, uranium geochemistry, mineralogy and mobility, the instrumentation and techniques used in uranium exploration, for example, borehole logging, radon emanometry and airborne radiometric surveys and also data processing and interpretation methods

  18. Prospective Lymphedema Surveillance in a Clinic Setting

    OpenAIRE

    Janet Chance-Hetzler; Jane Armer; Maggie Van Loo; Blake Anderson; Robin Harris; Rebecca Ewing; Bob Stewart

    2015-01-01

    The potential impact of breast cancer-related lymphedema (LE) is quite extensive, yet it often remains under-diagnosed until the later stages. This project examines the effectiveness of prospective surveillance in post-surgical breast cancer patients. A retrospective analysis of 49 out of 100 patients enrolled in a longitudinal prospective study at a Midwestern breast center evaluates: (1) time required for completion of bilateral limb measurements and Lymphedema Breast Cancer Questionnaire (...

  19. DADOS-Prospective: an open source application for Web-based prospective data collection

    Directory of Open Access Journals (Sweden)

    Nguyen Lam

    2006-11-01

    Full Text Available Abstract Background Randomized, prospective trials involving multi-institutional collaboration have become a central part of clinical and translational research. However, data management and coordination of multi-center studies is a complex process that involves developing systems for data collection and quality control, tracking data queries and resolutions, as well as developing communication procedures. We describe DADOS-Prospective, an open-source Web-based application for collecting and managing prospective data on human subjects for clinical and translational trials. DADOS-Prospective not only permits users to create new clinical research forms (CRF and supports electronic signatures, but also offers the advantage of containing, in a single environment, raw research data in downloadable spreadsheet format, source documentation and regulatory files stored in PDF format, and audit trails. Results Feedback from formal and field usability tests was used to guide the design and development of DADOS-Prospective. To date, DADOS-Prospective has been implemented in five prospective clinical studies at our institution. Four of these studies are still in the CRF creation phase and one study has been entirely launched. Conclusion DADOS-Prospective has significant advantages over existing Web-based data collecting programs. At our institution, it has been demonstrated to be an efficient tool for prospective clinical studies.

  20. Prospecting for marine gas hydrate resources

    Science.gov (United States)

    Boswell, Ray; Shipp, Craig; Reichel, Thomas; Shelander, Dianna; Saeki, Tetsuo; Frye, Matthew; Shedd, William; Collett, Timothy S.; McConnell, Daniel R.

    2016-01-01

    As gas hydrate energy assessment matures worldwide, emphasis has evolved away from confirmation of the mere presence of gas hydrate to the more complex issue of prospecting for those specific accumulations that are viable resource targets. Gas hydrate exploration now integrates the unique pressure and temperature preconditions for gas hydrate occurrence with those concepts and practices that are the basis for conventional oil and gas exploration. We have aimed to assimilate the lessons learned to date in global gas hydrate exploration to outline a generalized prospecting approach as follows: (1) use existing well and geophysical data to delineate the gas hydrate stability zone (GHSZ), (2) identify and evaluate potential direct indications of hydrate occurrence through evaluation of interval of elevated acoustic velocity and/or seismic events of prospective amplitude and polarity, (3) mitigate geologic risk via regional seismic and stratigraphic facies analysis as well as seismic mapping of amplitude distribution along prospective horizons, and (4) mitigate further prospect risk through assessment of the evidence of gas presence and migration into the GHSZ. Although a wide range of occurrence types might ultimately become viable energy supply options, this approach, which has been tested in only a small number of locations worldwide, has directed prospect evaluation toward those sand-hosted, high-saturation occurrences that were presently considered to have the greatest future commercial potential.

  1. Ecological reality and model validation

    Energy Technology Data Exchange (ETDEWEB)

    Cale, Jr, W. G.; Shugart, H. H.

    1980-01-01

    Definitions of model realism and model validation are developed. Ecological and mathematical arguments are then presented to show that model equations which explicitly treat ecosystem processes can be systematically improved such that greater realism is attained and the condition of validity is approached. Several examples are presented.

  2. Model validation, science and application

    NARCIS (Netherlands)

    Builtjes, P.J.H.; Flossmann, A.

    1998-01-01

    Over the last years there is a growing interest to try to establish a proper validation of atmospheric chemistry-transport (ATC) models. Model validation deals with the comparison of model results with experimental data, and in this way adresses both model uncertainty and uncertainty in, and adequac

  3. Compiler validates units and dimensions

    Science.gov (United States)

    Levine, F. E.

    1980-01-01

    Software added to compiler for automated test system for Space Shuttle decreases computer run errors by providing offline validation of engineering units used system command programs. Validation procedures are general, though originally written for GOAL, a free-form language that accepts "English-like" statements, and may be adapted to other programming languages.

  4. Cleaning Validation of Fermentation Tanks

    DEFF Research Database (Denmark)

    Salo, Satu; Friis, Alan; Wirtanen, Gun

    2008-01-01

    Reliable test methods for checking cleanliness are needed to evaluate and validate the cleaning process of fermentation tanks. Pilot scale tanks were used to test the applicability of various methods for this purpose. The methods found to be suitable for validation of the clenlinees were visula...

  5. Original and cumulative prospect theory: a discussion of empirical differences

    NARCIS (Netherlands)

    P.P. Wakker; H. Fennema

    1997-01-01

    This note discusses differences between prospect theory and cumulative prospect theory. It shows that cumulative prospect theory is not merely a formal correction of some theoretical problems in prospect theory, but it also gives different predictions. Experiments are described that favor cumulative

  6. Prospective Coding by Spiking Neurons.

    Directory of Open Access Journals (Sweden)

    Johanni Brea

    2016-06-01

    Full Text Available Animals learn to make predictions, such as associating the sound of a bell with upcoming feeding or predicting a movement that a motor command is eliciting. How predictions are realized on the neuronal level and what plasticity rule underlies their learning is not well understood. Here we propose a biologically plausible synaptic plasticity rule to learn predictions on a single neuron level on a timescale of seconds. The learning rule allows a spiking two-compartment neuron to match its current firing rate to its own expected future discounted firing rate. For instance, if an originally neutral event is repeatedly followed by an event that elevates the firing rate of a neuron, the originally neutral event will eventually also elevate the neuron's firing rate. The plasticity rule is a form of spike timing dependent plasticity in which a presynaptic spike followed by a postsynaptic spike leads to potentiation. Even if the plasticity window has a width of 20 milliseconds, associations on the time scale of seconds can be learned. We illustrate prospective coding with three examples: learning to predict a time varying input, learning to predict the next stimulus in a delayed paired-associate task and learning with a recurrent network to reproduce a temporally compressed version of a sequence. We discuss the potential role of the learning mechanism in classical trace conditioning. In the special case that the signal to be predicted encodes reward, the neuron learns to predict the discounted future reward and learning is closely related to the temporal difference learning algorithm TD(λ.

  7. Jojoba: an assessment of prospects

    Energy Technology Data Exchange (ETDEWEB)

    Walters, P.R.; MacFarlane, W.; Spensley, P.C.

    1979-01-01

    Jojoba (Simmondsia chinensis) is a crop that might be cultivated profitably in the arid and semi-arid zones of certain cultivated profitably in the arid and semi-arid zones of certain developing countries. This report assesses the present state of research on the crop and gives an opinion as to its prospects of being of economic benefit to these areas. The report is divided into five sections. In Section 1 the plant and its natural habitats are described and current research and the problems to be overcome in cultivating the crop are outlined. In Section 2 the chemistry of jojoba and other waxes is discussed. In Section 3 consideration is given to the end-use potential of jojoba and an attempt is made to forecast the future market demand and price for jojoba oil, both as a liquid and as a solid wax. In Section 4 the economics of jojoba production are discussed in light of the findings in the earlier sections. Finally, in Section 5, the wider aspects of plant introductions are considered briefly and conclusions drawn regarding jojoba's potential and its future research needs. It will be essential to increase jojoba yield significantly before cultivation will be viable except on a small scale. A satisfactory mechanized harvesting system also needs to be developed. The market for jojoba oil at various levels of production is estimated at production of less than 1000 tons (pounds-sterling 5500- pounds-sterling 7700 per ton); production of 2000 to 5000 tons (pounds-sterling 900- pounds-sterling 950 per ton); and production up to 20,000 tons (pounds-sterling 500-pounds-sterling 600 per ton).

  8. [Prospective evaluation of antidepressant discontinuation].

    Science.gov (United States)

    Mourad, I; Lejoyeux, M; Adès, J

    1998-01-01

    The authors prospectively assessed symptoms induced by the interruption of antidepressants in 16 patients (11 women and 5 men), aged from 33 to 85 years (mean = 52.4 +/- 16.4), treated with antidepressants since at least two weeks. All patients were free of alcohol abuse or dependence disorder and of other dependence to psychoactive substances. None of them presented medical illness. Diagnosis were made by separate evaluations by two authors and confirmed with a semistructered assessment instrument: the Schedule for Affective Disorders and Schizophrenia (Lifetime Version). All patients were submitted to a brutal discontinuation of their antidepressant agent. Patients were assessed twice, before the interruption of the antidepressant, and 72 hours later. Effects of antidepressant interruption were assessed by several means. Modification of anxiety and depression were evaluated using the Montgomery Asberg Depression Rating Scale (MADRS) and the Hamilton Anxiety Scale. Symptoms of withdrawal were assessed with Cassano and al.'s scale SESSH including an evaluation of anxiety, agitation, irritability, anergy, difficulty on concentrating, depersonalization, sleep and appetite disorders, muscle pains, nausea, tremor, sweating, altered taste, hyperosmia, paresthesias, photophobia, motor incoordination, dizziness, hyperacousia pain, delirium. Fourteen of the 16 patients (87.5%) presented modifications of their somatic or psychic state 3 days after the interruption of the antidepressant treatment. Most frequent symptoms were: increase in anxiety (31%), increase in irritability (25%), sleep disorders (19%), decrease of anergia and fatigue (19%). Mean scores of anxiety and depression were not significantly modified by the withdrawal. Following TCAs interruption (7 patients) most frequent symptoms were sleep disorders; increase in anxiety, nausea. Among patients withdrawn from SSRIs (6 patients), most frequent symptoms were increase in anxiety, increase in irritability

  9. Photovoltaic electricity prospects in Oman

    International Nuclear Information System (INIS)

    Although considerable progress has been achieved in supplying electricity to most parts of Oman, due to its population dispersion, economic constraints and the short duration of the national electrification-programme to date (i.e. less than 30 years), there are still some locations without this desirable service. Electricity is the premium form of energy, because it is clean, as well as being flexible and highly efficient at its point-of-use. The availability of the first few kilowatts of electricity to a previously non-electrified home greatly improves the quality of life for its inhabitants, far more so than any subsequent equal increment of supplied power. For instance, this initial provision could energise artificial lighting, as well as a telephone, a T.V. set, or a refrigerator and so enhance significantly the life-style quality of a household. Photovoltaic (PV) technology has already demonstrated its effectiveness and holds great promise for electricity generation but, at present, is a relatively high capital-cost process. Nevertheless, it provides an opportunity to generate electricity quietly via a semi-conductor system, using no rotating parts, and requiring no fossil-fuel input because it depends on insolation and so emits no pollutants. Therefore, for some applications, e.g. railway signalling or buoy illumination, it is, even now, in common usage worldwide. PV-electricity generation tends to be more cost effective in the 'sun-belt' region from about 40oN to 40oS: Oman lies within this region, i.e. between 17oN and 26oN, and hence the prospects for its exploitation there on a large scale are good. (author)

  10. Prospective Optimization with Limited Resources.

    Science.gov (United States)

    Snider, Joseph; Lee, Dongpyo; Poizner, Howard; Gepshtein, Sergei

    2015-09-01

    The future is uncertain because some forthcoming events are unpredictable and also because our ability to foresee the myriad consequences of our own actions is limited. Here we studied how humans select actions under such extrinsic and intrinsic uncertainty, in view of an exponentially expanding number of prospects on a branching multivalued visual stimulus. A triangular grid of disks of different sizes scrolled down a touchscreen at a variable speed. The larger disks represented larger rewards. The task was to maximize the cumulative reward by touching one disk at a time in a rapid sequence, forming an upward path across the grid, while every step along the path constrained the part of the grid accessible in the future. This task captured some of the complexity of natural behavior in the risky and dynamic world, where ongoing decisions alter the landscape of future rewards. By comparing human behavior with behavior of ideal actors, we identified the strategies used by humans in terms of how far into the future they looked (their "depth of computation") and how often they attempted to incorporate new information about the future rewards (their "recalculation period"). We found that, for a given task difficulty, humans traded off their depth of computation for the recalculation period. The form of this tradeoff was consistent with a complete, brute-force exploration of all possible paths up to a resource-limited finite depth. A step-by-step analysis of the human behavior revealed that participants took into account very fine distinctions between the future rewards and that they abstained from some simple heuristics in assessment of the alternative paths, such as seeking only the largest disks or avoiding the smaller disks. The participants preferred to reduce their depth of computation or increase the recalculation period rather than sacrifice the precision of computation.

  11. Energy intensities: Prospects and potential

    International Nuclear Information System (INIS)

    In the previous chapter, the author described how rising activity levels and structural change are pushing toward higher energy use in many sectors and regions, especially in the developing countries. The extent to which more activity leads to greater energy use will depend on the energy intensity of end-use activities. In this chapter, the author presents an overview of the potential for intensity reductions in each sector over the next 10-20 years. It is not the author's intent to describe in detail the various technologies that could be employed to improve energy efficiency, which has been done by others (see, for example, Lovins ampersand Lovins, 1991; Goldembert et al., 1987). Rather, he discusses the key factors that will shape future energy intensities in different parts of the world, and gives a sense for the changes that could be attained if greater attention were given to accelerate efficiency improvement. The prospects for energy intensities, and the potential for reduction, vary among sectors and parts of the world. In the majority of cases, intensities are tending to decline as new equipment and facilities come into use and improvements are made on existing stocks. The effect of stock turnover will be especially strong in the developing countries, where stocks are growing at a rapid pace, and the Former East Bloc, where much of the existing industrial plant will eventually be retired and replaced with more modern facilities. While reductions in energy intensity are likely in most areas, there is a large divergence between the technical and economic potential for reducing energy intensities and the direction in which present trends are moving. In the next chapter, the author presents scenarios that illustrate where trends are pointing, and what could be achieved if improving energy efficiency were a focus of public policies. 53 refs., 4 figs., 2 tabs

  12. Failure mode and effects analysis outputs: are they valid?

    Directory of Open Access Journals (Sweden)

    Shebl Nada

    2012-06-01

    Full Text Available Abstract Background Failure Mode and Effects Analysis (FMEA is a prospective risk assessment tool that has been widely used within the aerospace and automotive industries and has been utilised within healthcare since the early 1990s. The aim of this study was to explore the validity of FMEA outputs within a hospital setting in the United Kingdom. Methods Two multidisciplinary teams each conducted an FMEA for the use of vancomycin and gentamicin. Four different validity tests were conducted: · Face validity: by comparing the FMEA participants’ mapped processes with observational work. · Content validity: by presenting the FMEA findings to other healthcare professionals. · Criterion validity: by comparing the FMEA findings with data reported on the trust’s incident report database. · Construct validity: by exploring the relevant mathematical theories involved in calculating the FMEA risk priority number. Results Face validity was positive as the researcher documented the same processes of care as mapped by the FMEA participants. However, other healthcare professionals identified potential failures missed by the FMEA teams. Furthermore, the FMEA groups failed to include failures related to omitted doses; yet these were the failures most commonly reported in the trust’s incident database. Calculating the RPN by multiplying severity, probability and detectability scores was deemed invalid because it is based on calculations that breach the mathematical properties of the scales used. Conclusion There are significant methodological challenges in validating FMEA. It is a useful tool to aid multidisciplinary groups in mapping and understanding a process of care; however, the results of our study cast doubt on its validity. FMEA teams are likely to need different sources of information, besides their personal experience and knowledge, to identify potential failures. As for FMEA’s methodology for scoring failures, there were discrepancies

  13. Structure validation in chemical crystallography.

    Science.gov (United States)

    Spek, Anthony L

    2009-02-01

    Automated structure validation was introduced in chemical crystallography about 12 years ago as a tool to assist practitioners with the exponential growth in crystal structure analyses. Validation has since evolved into an easy-to-use checkCIF/PLATON web-based IUCr service. The result of a crystal structure determination has to be supplied as a CIF-formatted computer-readable file. The checking software tests the data in the CIF for completeness, quality and consistency. In addition, the reported structure is checked for incomplete analysis, errors in the analysis and relevant issues to be verified. A validation report is generated in the form of a list of ALERTS on the issues to be corrected, checked or commented on. Structure validation has largely eliminated obvious problems with structure reports published in IUCr journals, such as refinement in a space group of too low symmetry. This paper reports on the current status of structure validation and possible future extensions.

  14. Managing Real-time Collaboration in Validated Content Management System

    Directory of Open Access Journals (Sweden)

    Zakaria Itahriouan

    2013-06-01

    Full Text Available Content Management Systems (CMS provide to its users the ability to publish on the Web with no need to have experience in developing web pages, this way CMS also participates in the expansion of reducing quality of content placed on the web similarly to Web 2.0 tools. The mechanism of validating content indicates a high level of quality content control while putting users as main players according to Web 2.0 standards, from this prospects we develop Validated Content Management System VCMS as a new Web 2.0 tool that supports content validation mechanism. The VCMS system requires collaboration between users when content is being static validated. Real-time synchronization between users during collaboration on the same project can make this process easier and brings more rapidity to content publication while maintaining the mechanisms that allows quality control in our system. In this article we present the technic of implementing real time interaction between users during collaboration on the same content. We focus on promoting the What You See Is What You Get (WYSIWYG editor to support Real-time collaboration between multiple content generators. . The approach presented in this paper can be integrated to any collaborative Content Management System and also can be used in all collaborative applications that generate Web content such as blogs or wikis offering to these tools the feature of collaborating on the same content between multiple users in real-time.

  15. Validation of the ECOS-16 Questionnaire in Koreans with Osteoporosis

    Science.gov (United States)

    Son, Seung Min; Goh, Tae Sik; Kim, Taek Hoon; Noh, Eun Yeong

    2016-01-01

    Study Design Prospective study. Purpose To evaluate the reliability and validity of the adapted Korean version of the Quality of Life Questionnaire of the European Foundation for Osteoporosis (ECOS-16). Overview of Literature The validity of the Korean version of ECOS-16 has not been completely demonstrated. Methods Translation/retranslation of the English version of ECOS-16, and full cross-cultural adaptation were performed. The Korean version of a visual analog scale measure of pain, and the Korean versions of ECOS-16 and of the previously validated short form-36 (SF-36) were mailed to 158 consecutive patients with osteoporosis. Factor analysis and reliability assessment using kappa statistics of agreement for each item, intraclass correlation coefficient, and Cronbach's α were done. Construct validity was evaluated by comparing responses to ECOS-16 with responses to SF-36 using Pearson's correlation coefficient. Results Factor analysis extracted three factors. All items had a kappa statistics of agreement >0.6. The ECOS-16 showed good test/re-test reliability (0.8469) and internal consistency of Cronbach's α (0.897). The Korean version of ECOS-16 showed significant correlation with SF-36 total scores and with single SF-36 domains scores. Conclusions The adapted Korean version of the ECOS-16 was successfully translated and showed acceptable measurement properties. It is considered suitable for outcome assessments in Korean patients with osteoporosis. PMID:27790315

  16. The Measurement of Executive Function at Age 3 Years: Psychometric Properties and Criterion Validity of a New Battery of Tasks

    Science.gov (United States)

    Willoughby, Michael T.; Blair, Clancy B.; Wirth, R. J.; Greenberg, Mark

    2010-01-01

    In this study, the authors examined the psychometric properties and criterion validity of a newly developed battery of tasks that were designed to assess executive function (EF) abilities in early childhood. The battery was included in the 36-month assessment of the Family Life Project (FLP), a prospective longitudinal study of 1,292 children…

  17. External validation and updating of a Dutch prediction model for low hemoglobin deferral in Irish whole blood donors

    NARCIS (Netherlands)

    Baart, A.M.; Atsma, F.; McSweeney, E.N.; Moons, K.G.; Vergouwe, Y.; Kort, W.L. de

    2014-01-01

    BACKGROUND: Recently, sex-specific prediction models for low hemoglobin (Hb) deferral have been developed in Dutch whole blood donors. In the present study, we validated and updated the models in a cohort of Irish whole blood donors. STUDY DESIGN AND METHODS: Prospectively collected data from 45,031

  18. Differential Predictive Validity of High School GPA and College Entrance Test Scores for University Students in Yemen

    Science.gov (United States)

    Al-Hattami, Abdulghani Ali Dawod

    2012-01-01

    High school grade point average and college entrance test scores are two admission criteria that are currently used by most colleges in Yemen to select their prospective students. Given their widespread use, it is important to investigate their predictive validity to ensure the accuracy of the admission decisions in these institutions. This study…

  19. Validation of the Emergency Severity Index (ESI) in self-referred patients in a European emergency department.

    NARCIS (Netherlands)

    Elshove-Bolk, J.; Mencl, F.; Rijswijck, B.T. van; Simons, M.P.; Vugt, A.B. van

    2007-01-01

    OBJECTIVE: To validate the Emergency Severity Index (ESI) triage algorithm in predicting resource consumption and disposition by self-referred patients in a European emergency department. METHODS: This was a prospective, observational cohort study using a convenience sample of self-referred emergenc

  20. Development and validation of prognostic models designed to predict wheelchair skills at discharge from spinal cord injury rehabilitation

    NARCIS (Netherlands)

    de Groot, S.; Bevers, G. E.; Dallmeijer, A. J.; Post, M. W. M.; van Kuppevelt, H. J. M.; van der Woude, L. H. V.

    2010-01-01

    Objective: To develop and validate a statistical model to predict wheelchair skills at discharge (t(2)) from personal and lesion characteristics and wheelchair skills at the start of spinal cord injury inpatient rehabilitation (t(1)). Design: Prospective cohort study Setting: Eight Dutch rehabilitat

  1. Prospective Ukrainian lunar orbiter mission

    Science.gov (United States)

    Shkuratov, Y.; Litvinenko, L.; Shulga, V.; Yatskiv, Y.; Kislyuk, V.

    Ukraine has launch vehicles that are able to deliver about 300 kg to the lunar orbit. Future Ukrainian lunar program may propose a polar orbiter. This orbiter should fill principal information gaps in our knowledge about the Moon after Clementine and Lunar Prospector missions and the future missions, like Smart-1, Lunar-A, and Selene. We consider that this can be provided by radar studies of the Moon with supporting optical polarimetric observations from lunar polar orbit. These experiments allow one to better understand global structure of the lunar surface in a wide range of scales, from microns to kilometers. We propose three instruments for the prospective lunar orbiter. They are: a synthetic aperture imaging radar (SAR), ground-penetrating radar (GPR), and imaging polarimeter (IP). The main purpose of SAR is to study with high resolution (50 m) the permanently shadowed sites in the lunar polar regions. These sites are cold traps for volatiles, and have a potential of resource utilization. Possible presence of water ice in the regolith in the sites makes them interesting for permanent manned bases on the Moon. Radar imaging and mapping of other interesting regions could be also planned. Multi-frequencies multi-polarization soun d ing of the lunar surface with GPR can provide information about internal structure of the lunar surface from meters to several hundred meters deep. GPR can be used for measuring the megaregolith layer properties, detection of cryptomaria, and studies of internal structure of the largest craters. IP will be a CCD camera with an additional suite of polarizers. Modest spatial resolution (100 m) should provide a total coverage or a large portion of the lunar surface in oblique viewing basically at large phase angles. Polarization degree at large (>90°) phase angles bears information about characteristic size of the regolith particles. Additional radiophysical experiments are considered with the use of the SAR system, e.g., bistatic radar

  2. Neurocutaneous syndrome: A prospective study

    Directory of Open Access Journals (Sweden)

    Radheshyam Purkait

    2011-01-01

    Full Text Available Background: Neurocutaneous syndromes (NCS are a group of genetic disorders that produce a variety of developmental abnormalities of the skin along with an increased risk of neurological complications. Cutaneous manifestations usually appear early in life and progress with time, but neurological features generally present at a later age. There is a paucity of data regarding the evolution of skin lesions and their correlation with the central nervous system involvement in children. Aim: The primary objective was to track the course of skin lesions in various forms of NCS in the pediatric age group. Our secondary aim was to assess whether there was any predictive value of the lesions in relation to the neurological manifestations. Materials and Methods: This prospective longitudinal study was conducted at a tertiary care pediatric dermatology referral clinic of the Institute of Child Health, Kolkata, West Bengal. Children between the age group 0 and 12 years were included in the study on the basis of standard diagnostic criteria for different NCS, during the period from March, 2000 to February, 2004, and each of the enrolled cases were followed up for a duration of six years. Results: The study population comprised of 67 children (35 boys, 32 girls.The mean age of presentation was 33.8±27.8 months (range 10 days to 111 months. The various forms of NCS observed was neurofibromatosis 1(NF1 (n=33, tuberous sclerosis complex (TSC (n=23, Sturge Weber syndrome (n=6, ataxia telangiectasia (n=2, PHACE syndrome (n=1, incontinentia pigmenti (n=1, and hypomelanosis of Ito (n=1. The presentations were varied, ranging from predominantly cutaneous to primarily neurological, depending on the disease entity and age group concerned. There was a significant increase in the number of café au lait macules (CALMs with time (P=0.0002 in NF1, unlike that of hypopigmented macules of TSC (P=0.15. Statistically, no relation was documented between the evolution of skin

  3. The data of Lelvy and Levy , "Prospect theory: much ado about nothing??", support prospect theory

    NARCIS (Netherlands)

    P.P. Wakker

    2003-01-01

    Levy and Levy (Management Science, 2002) present data that, according to their claims, violate prospect theory. They suggest that prospect theoryys hypothesis of an S-shaped value function, concave for gains and convex for losses, is incorrect. However, all of the data of Levy and Levy are perfectly

  4. Loads and loads and loads: the influence of prospective load, retrospective load, and ongoing task load in prospective memory

    OpenAIRE

    Beat eMeier; Zimmermann, Thomas D.

    2015-01-01

    In prospective memory tasks different kinds of load can occur. Adding a prospective memory task can impose a load on ongoing task performance. Adding ongoing task load can affect prospective memory performance. The existence of multiple target events increases prospective load and adding complexity to the to-be-remembered action increases retrospective load. In two experiments, we systematically examined the effects of these different types of load on prospective memory performance. Results s...

  5. The application actualities and prospects of geophysical methods to uranium prospecting

    International Nuclear Information System (INIS)

    Basic principles of geophysical methods to uranium prospect are briefly introduced, and the effects as well as problems in using those methods are analysed respectively. Combining with the increasing demand of uranium resources for Chinese nuclear power development and the higher requirements of geophysical techniques, the developing directions and the thoughts of geophysical techniques in uranium prospecting were proposed. A new pattern with producing, teaching and researching together is brought forward to develop advancing uranium prospecting key technologies and to break through technological bottlenecks depending on independent innovation. Integrated geophysical methods for prospecting uranium deposits are suggested. The method includes geophysical techniques as follows: gravity, magnetic, seismic, radioactive, remote sensing, and geochemical method in some proving grounds. Based on the experimental research, new uranium deposits prospecting models with efficient integrated geophysical methods can be established. (authors)

  6. An ecological approach to prospective and retrospective timing of long durations: a study involving gamers.

    Directory of Open Access Journals (Sweden)

    Simon Tobin

    Full Text Available To date, most studies comparing prospective and retrospective timing have failed to use long durations and tasks with a certain degree of ecological validity. The present study assessed the effect of the timing paradigm on playing video games in a "naturalistic environment" (gaming centers. In addition, as it involved gamers, it provided an opportunity to examine the effect of gaming profile on time estimation. A total of 116 participants were asked to estimate prospectively or retrospectively a video game session lasting 12, 35 or 58 minutes. The results indicate that time is perceived as longer in the prospective paradigm than in the retrospective one, although the variability of estimates is the same. Moreover, the 12-minute session was perceived as longer, proportionally, than the 35- and 58-minute sessions. The study also revealed that the number of hours participants spent playing video games per week was a significant predictor of time estimates. To account for the main findings, the differences between prospective and retrospective timing are discussed in quantitative terms using a proposed theoretical framework, which states that both paradigms use the same cognitive processes, but in different proportions. Finally, the hypothesis that gamers play more because they underestimate time is also discussed.

  7. Prospect theory in the valuation of health.

    Science.gov (United States)

    Moffett, Maurice L; Suarez-Almazor, Maria E

    2005-08-01

    Prospect theory is the prominent nonexpected utility theory in the estimation of health state preference scores for quality-adjusted life year calculation. Until recently, the theory was not considered to be developed to the point of implementation in economic analysis. This review focuses on the research and evidence that tests the implementation of prospect theory into health state valuation. The typical application of expected utility theory assumes that a decision maker has stable preferences under conditions of risk and uncertainty. Under prospect theory, preferences are dependent on whether the decision maker regards the outcome of a choice as a gain or loss, relative to a reference point. The conceptual preference for standard gamble utilities in the valuation of health states has led to the development of elicitation techniques. Empirical evidence using these techniques indicates that when individual preferences are elicited, a prospect theory consistent framework appears to be necessary for adequate representation of individual health utilities. The relevance of prospect theory to policy making and resource allocation remains to be established. Societal preferences may not need the same attitudes towards risks as individual preferences, and may remain largely risk neutral. PMID:19807267

  8. Validation of the CoRE Questionnaire for a Medical Journal Peer Review.

    Science.gov (United States)

    Doi, Suhail A R; Salzman-Scott, Sherry A; Onitilo, Adedayo A

    2016-01-01

    If a peer review instrument asks concrete questions (defined as items that can only generate disagreement if reviewers have different degrees of expertise), then questionnaires could become more meaningful in terms of resolving subjectivity thus leading to more reviewer agreement. A concrete item questionnaire with well-chosen questions can also help resolve disagreement when reviewers have the same level of expertise. We have recently created the core-item reviewer evaluation (CoRE) questionnaire for which decision-threshold score levels have been created, but which have not been validated. This prospective validation of these thresholds for the CoRE questionnaire demonstrated strong agreement between reviewer recommendations and their reported score levels when tested prospectively at Clinical Medicine and Research. We conclude that using the CoRE questionnaire will help reduce peer reviewer disagreement. More importantly, when reviewer expertise varies, editors can more easily detect this and decide which opinion reflects the greater expertise. PMID:26192007

  9. Base Flow Model Validation Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The innovation is the systematic "building-block" validation of CFD/turbulence models employing a GUI driven CFD code (RPFM) and existing as well as new data sets...

  10. Validation of Plant Virus Detection

    NARCIS (Netherlands)

    Schadewijk, van A.R.; Meekes, E.T.M.; Verbeek, M.; Verhoeven, J.Th.J.

    2011-01-01

    Validation of test methods is required for laboratories seeking ISO 17025 accreditation. Recently developed manuals help choosing relevant performance characteristics to be studied for qualitative tests common in plant virus detection. For routine testing in certification schemes additional informat

  11. Assessment of juveniles testimonies’ validity

    OpenAIRE

    Dozortseva E.G.; Afanasyeva A.G.

    2015-01-01

    The article presents a review of the English language publications concerning the history and the current state of differential psychological assessment of validity of testimonies produced by child and adolescent victims of crimes. The topicality of the problem in Russia is high due to the tendency of Russian specialists to use methodical means and instruments developed abroad in this sphere for forensic assessments of witness testimony veracity. A system of Statement Validity Analysis (SVA) ...

  12. Automatic validation of numerical solutions

    DEFF Research Database (Denmark)

    Stauning, Ole

    1997-01-01

    This thesis is concerned with ``Automatic Validation of Numerical Solutions''. The basic theory of interval analysis and self-validating methods is introduced. The mean value enclosure is applied to discrete mappings for obtaining narrow enclosures of the iterates when applying these mappings...... of an integral operator and uses interval Bernstein polynomials for enclosing the solution. Two numerical examples are given, using two orders of approximation and using different numbers of discretization points....

  13. Scenarios planning: the evolution of prospective thinking

    Directory of Open Access Journals (Sweden)

    Maurício Fernandes Pereira

    2005-01-01

    Full Text Available The world is changing even more than before. Around the world, the organizational stability is in face of threats unnoticed before, due to technologic innovations, uncontrolled financial markets, up to date customers, and an observant society and government, in order to control the organizations’ social and environmental responsibilities. To face this threats, organizations needs to worry even more, renew its long range planning systems, and use Prospective Scenaries to find out, in a better way, the dynamic forces that will preveil in the next years. This paper seeks to clarify the source of prospective thinking that has created and developed this tool. Prospective Thinking is considered, nowadays, one of most innovatives tools used by the strategic management in organizations.

  14. A prospective study of gentamicin ototoxicity

    DEFF Research Database (Denmark)

    Winkel, O; Hansen, M M; Kaaber-Bühler, Søren;

    2010-01-01

    Twenty patients were included in a prospective otoneurological study performed to assess the ototoxicity in gentamicin therapy. Gentamicin was administered intravenously, and the serum level was currently determined. Audiographic and electronystagmographic studies were carried out at the institut......Twenty patients were included in a prospective otoneurological study performed to assess the ototoxicity in gentamicin therapy. Gentamicin was administered intravenously, and the serum level was currently determined. Audiographic and electronystagmographic studies were carried out...... of gentamicin did not rule out the possiblity of ototoxicity. These results urge the continuing of prospective studies and indicate that gentamicin should be used only as a link in the primary treatment of severe infection or in cases in which other, less toxic agents have failed....

  15. Prospect theory for online financial trading.

    Science.gov (United States)

    Liu, Yang-Yu; Nacher, Jose C; Ochiai, Tomoshiro; Martino, Mauro; Altshuler, Yaniv

    2014-01-01

    Prospect theory is widely viewed as the best available descriptive model of how people evaluate risk in experimental settings. According to prospect theory, people are typically risk-averse with respect to gains and risk-seeking with respect to losses, known as the "reflection effect". People are much more sensitive to losses than to gains of the same magnitude, a phenomenon called "loss aversion". Despite of the fact that prospect theory has been well developed in behavioral economics at the theoretical level, there exist very few large-scale empirical studies and most of the previous studies have been undertaken with micro-panel data. Here we analyze over 28.5 million trades made by 81.3 thousand traders of an online financial trading community over 28 months, aiming to explore the large-scale empirical aspect of prospect theory. By analyzing and comparing the behavior of winning and losing trades and traders, we find clear evidence of the reflection effect and the loss aversion phenomenon, which are essential in prospect theory. This work hence demonstrates an unprecedented large-scale empirical evidence of prospect theory, which has immediate implication in financial trading, e.g., developing new trading strategies by minimizing the impact of the reflection effect and the loss aversion phenomenon. Moreover, we introduce three novel behavioral metrics to differentiate winning and losing traders based on their historical trading behavior. This offers us potential opportunities to augment online social trading where traders are allowed to watch and follow the trading activities of others, by predicting potential winners based on their historical trading behavior.

  16. Prospect theory for online financial trading.

    Directory of Open Access Journals (Sweden)

    Yang-Yu Liu

    Full Text Available Prospect theory is widely viewed as the best available descriptive model of how people evaluate risk in experimental settings. According to prospect theory, people are typically risk-averse with respect to gains and risk-seeking with respect to losses, known as the "reflection effect". People are much more sensitive to losses than to gains of the same magnitude, a phenomenon called "loss aversion". Despite of the fact that prospect theory has been well developed in behavioral economics at the theoretical level, there exist very few large-scale empirical studies and most of the previous studies have been undertaken with micro-panel data. Here we analyze over 28.5 million trades made by 81.3 thousand traders of an online financial trading community over 28 months, aiming to explore the large-scale empirical aspect of prospect theory. By analyzing and comparing the behavior of winning and losing trades and traders, we find clear evidence of the reflection effect and the loss aversion phenomenon, which are essential in prospect theory. This work hence demonstrates an unprecedented large-scale empirical evidence of prospect theory, which has immediate implication in financial trading, e.g., developing new trading strategies by minimizing the impact of the reflection effect and the loss aversion phenomenon. Moreover, we introduce three novel behavioral metrics to differentiate winning and losing traders based on their historical trading behavior. This offers us potential opportunities to augment online social trading where traders are allowed to watch and follow the trading activities of others, by predicting potential winners based on their historical trading behavior.

  17. Prospects for stability in a nuclear subcontinent

    International Nuclear Information System (INIS)

    This book explore the prospects for stability in a nuclear sub-continent. The nonproliferation regimes and nuclear threat reduction, nonproliferation regimes and south asia - is there a meeting point?; maintaining a threshold of strategic autonomy at least cost: continuity in the evolution of India's nuclear policies; role of nuclear doctrines and the state of the armed forces in South Asia; nuclear weapons, deterrence and stability in the international system: South Asian dynamics; assessing China's Asian role and security policies; Kargil war to current threat of war: prospects for stability; discussion; international terrorism and its impact on South Asian stability; a view from Bangladesh etc. are some of the topics covered

  18. Collaborative Software Engineering: Challenges and Prospects

    Science.gov (United States)

    Mistrík, Ivan; Grundy, John; van der Hoek, André; Whitehead, Jim

    Much work is presently ongoing in collaborative software engineering research. This work is beginning to make serious inroads into our ability to more effectively practice collaborative software engineering, with best practices, processes, tools, metrics, and other techniques becoming available for day-to-day use. However, we have not yet reached the point where the practice of collaborative software engineering is routine, without surprises, and generally as optimal as possible. This chapter summarizes the main findings of this book, draws some conclusions on these findings and looks at the prospects for software engineers in dealing with the challenges of collaborative software development. The chapter ends with prospects for collaborative software engineering.

  19. Complications of ERCP: a prospective study

    DEFF Research Database (Denmark)

    Christensen, Merete; Matzen, Peter; Schulze, Svend;

    2004-01-01

    included in this prospective study. Complications were assessed at the time of ERCP and by postal/telephone contact at 30-days after the procedure. RESULTS: A total of 1177 ERCPs were included in the analysis, of which 56.2% were therapeutic. The 30-day complication rate was 15.9%; the procedure...... analysis. Risk of pancreatitis was increased with age under 40 years ( p = 0.0078), placement of stent ( p = 0.031), and a dilated bile duct ( p = 0.036). CONCLUSIONS: This prospective study confirms that the complication rate of ERCP including therapeutic procedures is high. Cardiopulmonary complications...

  20. Laparoendoscopic Single-Site Surgery for the Treatment of Benign Adnexal Disease: A Prospective Trial

    Directory of Open Access Journals (Sweden)

    Anna Fagotti

    2010-01-01

    Full Text Available Background. To validate feasibility, efficacy, and safeness of laparoscopic treatment of benign adnexal diseases through a single transumbilical access (LESS in a prospective series of patients. Methods. A prospective clinical trial including 30 women has been conducted at the Division of Gynecology of Catholic University of Sacred Hearth of Rome. Patients underwent different laparoscopic procedures by LESS utilizing a multiport trocar and conventional straight laparoscopic instrumentation. Intra and perioperative outcome has been reported. Results. Ten mono/bilateral adnexectomies and 20 cystectomies have been performed by LESS approach. Laparoscopic procedures were completed through a single access in 28 cases (93.4%. No major intra- or postoperative complications were observed. Mean hospital stay was 1.3 days. Conclusions. LESS approach is feasible to treat benign adnexal disease with a very low conversion rate and no early or late complications. More clinical data are needed to confirm these advantages compared to standard laparoscopic technique.

  1. Methylmercury Exposure and Incident Diabetes in U.S. Men and Women in Two Prospective Cohorts

    DEFF Research Database (Denmark)

    Mozaffarian, Dariush; Shi, Peilin; Morris, J Steven;

    2013-01-01

    OBJECTIVEEmerging in vitro and animal evidence suggests that methylmercury could increase type 2 diabetes, but little evidence exists in humans. We aimed to prospectively determine associations of mercury exposure, as assessed by biomarker measurement, with incident diabetes.RESEARCH DESIGN...... AND METHODSWe used neutron activation analysis to measure toenail mercury, an objective biomarker of methylmercury exposure, in 9,267 adults free of diabetes at baseline in two separate U.S. prospective cohorts. Incident diabetes was identified from biennial questionnaires and confirmed by validated...... supplementary questionnaire using symptoms, diagnostic tests, and medical therapy. Associations of mercury exposure with incident diabetes were assessed using Cox proportional hazards.RESULTSDuring mean ± SD follow-up of 19.7 ± 7.0 years, 1,010 new cases of diabetes were diagnosed. The 95th percentile...

  2. Modelling Freshwater Resources at the Global Scale: Challenges and Prospects

    Science.gov (United States)

    Döll, Petra; Douville, Hervé; Güntner, Andreas; Müller Schmied, Hannes; Wada, Yoshihide

    2016-03-01

    Quantification of spatially and temporally resolved water flows and water storage variations for all land areas of the globe is required to assess water resources, water scarcity and flood hazards, and to understand the Earth system. This quantification is done with the help of global hydrological models (GHMs). What are the challenges and prospects in the development and application of GHMs? Seven important challenges are presented. (1) Data scarcity makes quantification of human water use difficult even though significant progress has been achieved in the last decade. (2) Uncertainty of meteorological input data strongly affects model outputs. (3) The reaction of vegetation to changing climate and CO2 concentrations is uncertain and not taken into account in most GHMs that serve to estimate climate change impacts. (4) Reasons for discrepant responses of GHMs to changing climate have yet to be identified. (5) More accurate estimates of monthly time series of water availability and use are needed to provide good indicators of water scarcity. (6) Integration of gradient-based groundwater modelling into GHMs is necessary for a better simulation of groundwater-surface water interactions and capillary rise. (7) Detection and attribution of human interference with freshwater systems by using GHMs are constrained by data of insufficient quality but also GHM uncertainty itself. Regarding prospects for progress, we propose to decrease the uncertainty of GHM output by making better use of in situ and remotely sensed observations of output variables such as river discharge or total water storage variations by multi-criteria validation, calibration or data assimilation. Finally, we present an initiative that works towards the vision of hyperresolution global hydrological modelling where GHM outputs would be provided at a 1-km resolution with reasonable accuracy.

  3. Modelling Freshwater Resources at the Global Scale: Challenges and Prospects

    Science.gov (United States)

    Doll, Petra; Douville, Herve; Guntner, Andreas; Schmied, Hannes Muller; Wada, Yoshihide

    2015-01-01

    Quantification of spatially and temporally resolved water flows and water storage variations for all land areas of the globe is required to assess water resources, water scarcity and flood hazards, and to understand the Earth system. This quantification is done with the help of global hydrological models (GHMs). What are the challenges and prospects in the development and application of GHMs? Seven important challenges are presented. (1) Data scarcity makes quantification of human water use difficult even though significant progress has been achieved in the last decade. (2) Uncertainty of meteorological input data strongly affects model outputs. (3) The reaction of vegetation to changing climate and CO2 concentrations is uncertain and not taken into account in most GHMs that serve to estimate climate change impacts. (4) Reasons for discrepant responses of GHMs to changing climate have yet to be identified. (5) More accurate estimates of monthly time series of water availability and use are needed to provide good indicators of water scarcity. (6) Integration of gradient-based groundwater modelling into GHMs is necessary for a better simulation of groundwater-surface water interactions and capillary rise. (7) Detection and attribution of human interference with freshwater systems by using GHMs are constrained by data of insufficient quality but also GHM uncertainty itself. Regarding prospects for progress, we propose to decrease the uncertainty of GHM output by making better use of in situ and remotely sensed observations of output variables such as river discharge or total water storage variations by multi-criteria validation, calibration or data assimilation. Finally, we present an initiative that works towards the vision of hyper resolution global hydrological modelling where GHM outputs would be provided at a 1-km resolution with reasonable accuracy.

  4. ValidNESs: a database of validated leucine-rich nuclear export signals.

    Science.gov (United States)

    Fu, Szu-Chin; Huang, Hsuan-Cheng; Horton, Paul; Juan, Hsueh-Fen

    2013-01-01

    ValidNESs (http://validness.ym.edu.tw/) is a new database for experimentally validated leucine-rich nuclear export signal (NES)-containing proteins. The therapeutic potential of the chromosomal region maintenance 1 (CRM1)-mediated nuclear export pathway and disease relevance of its cargo proteins has gained recognition in recent years. Unfortunately, only about one-third of known CRM1 cargo proteins are accessible in a single database since the last compilation in 2003. CRM1 cargo proteins are often recognized by a classical NES (leucine-rich NES), but this signal is notoriously difficult to predict from sequence alone. Fortunately, a recently developed prediction method, NESsential, is able to identify good candidates in some cases, enabling valuable hints to be gained by in silico prediction, but until now it has not been available through a web interface. We present ValidNESs, an integrated, up-to-date database holding 221 NES-containing proteins, combined with a web interface to prediction by NESsential.

  5. Statistical validation of earthquake related observations

    Science.gov (United States)

    Kossobokov, V. G.

    2011-12-01

    The confirmed fractal nature of earthquakes and their distribution in space and time implies that many traditional estimations of seismic hazard (from term-less to short-term ones) are usually based on erroneous assumptions of easy tractable or, conversely, delicately-designed models. The widespread practice of deceptive modeling considered as a "reasonable proxy" of the natural seismic process leads to seismic hazard assessment of unknown quality, which errors propagate non-linearly into inflicted estimates of risk and, eventually, into unexpected societal losses of unacceptable level. The studies aimed at forecast/prediction of earthquakes must include validation in the retro- (at least) and, eventually, in prospective tests. In the absence of such control a suggested "precursor/signal" remains a "candidate", which link to target seismic event is a model assumption. Predicting in advance is the only decisive test of forecast/predictions and, therefore, the score-card of any "established precursor/signal" represented by the empirical probabilities of alarms and failures-to-predict achieved in prospective testing must prove statistical significance rejecting the null-hypothesis of random coincidental occurrence in advance target earthquakes. We reiterate suggesting so-called "Seismic Roulette" null-hypothesis as the most adequate undisturbed random alternative accounting for the empirical spatial distribution of earthquakes: (i) Consider a roulette wheel with as many sectors as the number of earthquake locations from a sample catalog representing seismic locus, a sector per each location and (ii) make your bet according to prediction (i.e., determine, which locations are inside area of alarm, and put one chip in each of the corresponding sectors); (iii) Nature turns the wheel; (iv) accumulate statistics of wins and losses along with the number of chips spent. If a precursor in charge of prediction exposes an imperfection of Seismic Roulette then, having in mind

  6. 4D micro-CT using fast prospective gating

    Science.gov (United States)

    Guo, Xiaolian; Johnston, Samuel M.; Qi, Yi; Johnson, G. Allan; Badea, Cristian T.

    2012-01-01

    Micro-CT is currently used in preclinical studies to provide anatomical information. But, there is also significant interest in using this technology to obtain functional information. We report here a new sampling strategy for 4D micro-CT for functional cardiac and pulmonary imaging. Rapid scanning of free-breathing mice is achieved with fast prospective gating (FPG) implemented on a field programmable gate array. The method entails on-the-fly computation of delays from the R peaks of the ECG signals or the peaks of the respiratory signals for the triggering pulses. Projection images are acquired for all cardiac or respiratory phases at each angle before rotating to the next angle. FPG can deliver the faster scan time of retrospective gating (RG) with the regular angular distribution of conventional prospective gating for cardiac or respiratory gating. Simultaneous cardio-respiratory gating is also possible with FPG in a hybrid retrospective/prospective approach. We have performed phantom experiments to validate the new sampling protocol and compared the results from FPG and RG in cardiac imaging of a mouse. Additionally, we have evaluated the utility of incorporating respiratory information in 4D cardiac micro-CT studies with FPG. A dual-source micro-CT system was used for image acquisition with pulsed x-ray exposures (80 kVp, 100 mA, 10 ms). The cardiac micro-CT protocol involves the use of a liposomal blood pool contrast agent containing 123 mg I ml-1 delivered via a tail vein catheter in a dose of 0.01 ml g-1 body weight. The phantom experiment demonstrates that FPG can distinguish the successive phases of phantom motion with minimal motion blur, and the animal study demonstrates that respiratory FPG can distinguish inspiration and expiration. 4D cardiac micro-CT imaging with FPG provides image quality superior to RG at an isotropic voxel size of 88 µm and 10 ms temporal resolution. The acquisition time for either sampling approach is less than 5 min. The

  7. Validating LES for Jet Aeroacoustics

    Science.gov (United States)

    Bridges, James

    2011-01-01

    Engineers charged with making jet aircraft quieter have long dreamed of being able to see exactly how turbulent eddies produce sound and this dream is now coming true with the advent of large eddy simulation (LES). Two obvious challenges remain: validating the LES codes at the resolution required to see the fluid-acoustic coupling, and the interpretation of the massive datasets that result in having dreams come true. This paper primarily addresses the former, the use of advanced experimental techniques such as particle image velocimetry (PIV) and Raman and Rayleigh scattering, to validate the computer codes and procedures used to create LES solutions. It also addresses the latter problem in discussing what are relevant measures critical for aeroacoustics that should be used in validating LES codes. These new diagnostic techniques deliver measurements and flow statistics of increasing sophistication and capability, but what of their accuracy? And what are the measures to be used in validation? This paper argues that the issue of accuracy be addressed by cross-facility and cross-disciplinary examination of modern datasets along with increased reporting of internal quality checks in PIV analysis. Further, it is argued that the appropriate validation metrics for aeroacoustic applications are increasingly complicated statistics that have been shown in aeroacoustic theory to be critical to flow-generated sound.

  8. Independent validation of ultrasonic inspection

    International Nuclear Information System (INIS)

    As a part of its inspection strategy for the Sizewell-B PWR station, the Central Electricity Generating Board (in part now Nuclear Electric) decided that the ultrasonic inspection procedures for the incredibility of failure components would be subjected to independent confirmation of their adequacy. The incorporation of validation into a large-scale inspection strategy was unique at the time (1982), indeed remains so today. The CEGB's general philosophy is one of diversity, redundancy and validation. In order to carry out independent validation of the specific procedures and ultrasonic operators to be used during the manufacture and in-service inspection of the reactor pressure vessel and steam plant components, the Inspection Validation Centre (IVC) has operated as a contractor to Nuclear Electric with special arrangements in place to guarantee independence. The setting-up and early methods of operation of IVC are briefly reviewed, the most recent operational experience summarized and the technical significance of the validations to date discussed. (author). 1 fig

  9. The Effect of Using Writer's Workshop Approach on Developing Basic Writing Skills (Mechanics of Writing) of Prospective Teachers of English in Egypt

    Science.gov (United States)

    Salem, Ashraf Atta M. S.

    2013-01-01

    The present study aimed at investigating the effects of using a program based on the writing workshop approach on developing basic writing skills of prospective teachers of English in Hurgada faculty of Education. For that purpose, the researcher constructed and validated a teaching program based on the writing workshop approach, checklist of the…

  10. Intakes of vitamins A, C and E and folate and multivitamins and lung cancer: A pooled analysis of 8 prospective studies

    NARCIS (Netherlands)

    Cho, E.; Hunter, D.J.; Spiegelman, D.; Albanes, D.; Beeson, W.L.; Brandt, P.A. van den; Colditz, G.A.; Feskanich, D.; Folsom, A.R.; Fraser, G.E.; Freudenheim, J.L.; Giovannucci, E.; Goldbohm, R.A.; Graham, S.; Miller, A.B.; Rohan, T.E.; Sellers, T.A.; Virtamo, J.; Willett, W.C.; Smith-Warner, S.A.

    2006-01-01

    Intakes of vitamins A, C and E and folate have been hypothesized to reduce lung cancer risk. We examined these associations in a pooled analysis of the primary data from 8 prospective studies from North America and Europe. Baseline vitamin intake was assessed using a validated food-frequency questio

  11. Plasma TIMP-1 and CEA in detection of primary colorectal cancer: a prospective, population based study of 4509 high-risk individuals

    DEFF Research Database (Denmark)

    Nielsen, Hans J; Brünner, Nils; Olsen, Jesper;

    2011-01-01

    Objective. The combination of plasma tissue inhibitor of metalloproteinases-1 (TIMP-1) and carcinoembryonic antigen (CEA) may be valuable biomarkers for early detection of colorectal cancer (CRC). A prospective, population based study was performed to validate this hypothesis. Material and method...

  12. Clinical Performance and Management Outcomes with the DecisionDx-UM Gene Expression Profile Test in a Prospective Multicenter Study

    Directory of Open Access Journals (Sweden)

    Kristen Meldi Plasseraud

    2016-01-01

    Full Text Available Uveal melanoma management is challenging due to its metastatic propensity. DecisionDx-UM is a prospectively validated molecular test that interrogates primary tumor biology to provide objective information about metastatic potential that can be used in determining appropriate patient care. To evaluate the continued clinical validity and utility of DecisionDx-UM, beginning March 2010, 70 patients were enrolled in a prospective, multicenter, IRB-approved study to document patient management differences and clinical outcomes associated with low-risk Class 1 and high-risk Class 2 results indicated by DecisionDx-UM testing. Thirty-seven patients in the prospective study were Class 1 and 33 were Class 2. Class 1 patients had 100% 3-year metastasis-free survival compared to 63% for Class 2 (log rank test p=0.003 with 27.3 median follow-up months in this interim analysis. Class 2 patients received significantly higher-intensity monitoring and more oncology/clinical trial referrals compared to Class 1 patients (Fisher’s exact test p=2.1×10-13 and p=0.04, resp.. The results of this study provide additional, prospective evidence in an independent cohort of patients that Class 1 and Class 2 patients are managed according to the differential metastatic risk indicated by DecisionDx-UM. The trial is registered with Clinical Application of DecisionDx-UM Gene Expression Assay Results (NCT02376920.

  13. Prospective Safety Analysis and the Complex Aviation System

    Science.gov (United States)

    Smith, Brian E.

    2013-01-01

    Fatal accident rates in commercial passenger aviation are at historic lows yet have plateaued and are not showing evidence of further safety advances. Modern aircraft accidents reflect both historic causal factors and new unexpected "Black Swan" events. The ever-increasing complexity of the aviation system, along with its associated technology and organizational relationships, provides fertile ground for fresh problems. It is important to take a proactive approach to aviation safety by working to identify novel causation mechanisms for future aviation accidents before they happen. Progress has been made in using of historic data to identify the telltale signals preceding aviation accidents and incidents, using the large repositories of discrete and continuous data on aircraft and air traffic control performance and information reported by front-line personnel. Nevertheless, the aviation community is increasingly embracing predictive approaches to aviation safety. The "prospective workshop" early assessment tool described in this paper represents an approach toward this prospective mindset-one that attempts to identify the future vectors of aviation and asks the question: "What haven't we considered in our current safety assessments?" New causation mechanisms threatening aviation safety will arise in the future because new (or revised) systems and procedures will have to be used under future contextual conditions that have not been properly anticipated. Many simulation models exist for demonstrating the safety cases of new operational concepts and technologies. However the results from such models can only be as valid as the accuracy and completeness of assumptions made about the future context in which the new operational concepts and/or technologies will be immersed. Of course that future has not happened yet. What is needed is a reasonably high-confidence description of the future operational context, capturing critical contextual characteristics that modulate

  14. Rural renewable energy (prospects) in Estonia

    Energy Technology Data Exchange (ETDEWEB)

    Tomson, T. [Estonian Energy Research Institute, Tallinn (Estonia); Kaeaermann, L. [Estonian National Maritime Board, Tallinn (Estonia); Raesaar, P. [Tallinn Technological University, Tallinn (Estonia)

    1997-12-31

    Total potential share of renewables (biomass, wind, hydropower and solar) in Estonia is 35 %. Total real share (wood, wood chips) of renewables is only about 4.5 % (1995). The constrains and prospects of the development are discussed. The attention is focused on rural conditions

  15. Continuing bonds and grief : a prospective analysis

    NARCIS (Netherlands)

    Boelen, Paul A; Stroebe, Margaret S; Schut, Henk A W; Zijerveld, Annemieke M

    2006-01-01

    Using data of 56 bereaved individuals, this study examined associations of various manifestations of continuing bonds, assessed at 7-12 months post-loss, with concurrent and prospective (9 months later) symptoms of grief and depression. Among other things it was found that, independent of initial sy

  16. Prospects of Employment Growth in Andhra Pradesh

    OpenAIRE

    Motkuri, Venkatanarayana

    2013-01-01

    The present paper examines the changes in work participation rates, participation rate in education and the growth of employment, and explores the prospects of employment growth in the state of Andhra Pradesh (India) in the scenario of declining population growth which acts as a limiting factors for the further employment growth.

  17. Russia's Precious Metals Market: Condition and Prospects

    Institute of Scientific and Technical Information of China (English)

    KOTLYAR A. Yu.

    2012-01-01

    The region of existence of phases in equilibrium with the solid solution based on palladium.Presented to analyze the current situation in the market of precious metals in Russia.Provides information about the production and processing of precious metals.Prospects for the most likely path of development of the Russian market of precious metals.

  18. Neutrino Experiments: Status, Recent Progress, and Prospects

    OpenAIRE

    Brice, Steve

    2007-01-01

    Neutrino physics has seen an explosion of activity and new results in the last decade. In this report the current state of the field is summarized, with a particular focus on progress in the last two years. Prospects for the near term (roughly 5 years) are also described.

  19. Strategic hospital marketing responses to prospective payment.

    Science.gov (United States)

    Rosko, M D; Broyles, R W

    1987-01-01

    Hospitals may respond to the revenue constraints of prospective payment by altering their patient mix. This article provided a brief overview of marketing management and suggested that hospitals might change their patient mix by employing marketing strategies designed to attract patients to its services or to attract physicians who specialize in the appropriate medical disciplines.

  20. Professional Leadership Aspirations of Prospective Women Teachers

    Science.gov (United States)

    McMillin, Marvin R.

    1972-01-01

    Results of the study seem to suggest that prospective women teachers are less likely to accept a leadership role as the level of responsibility increases and after an interruption in their career. They are also less likely to accept leadership roles in professional organizations. (Author/BY)

  1. A Prospective Study of Adolescent Pregnancy.

    Science.gov (United States)

    Hockaday, Cathy; Crase, Sedahlia Jasper; Shelley, Mack C., II; Stockdale, Dahlia F.

    2000-01-01

    Examines prospectively the characteristics contributing to adolescent pregnancy in a pregnant and comparison group of adolescents. Adolescent pregnancy in Blacks was predicted by approval of delaying a family and pursuing a career, aspirations of working, and lower educational expectations. Higher educational wishes, lower educational…

  2. Prospective associations between loneliness and emotional intelligence.

    Science.gov (United States)

    Wols, A; Scholte, R H J; Qualter, P

    2015-02-01

    Loneliness has been linked cross-sectionally to emotional skill deficits (e.g., Zysberg, 2012), but missing from the literature is a longitudinal examination of these relationships. The present study fills that gap by examining the prospective relationships between loneliness and emotional functioning in young adolescents in England. One hundred and ninety-six adolescents aged 11-13 years (90 females) took part in the study and completed the youth version of the Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT-YV) and the peer-related subscale of the Loneliness and Aloneness Scale for Children and Adolescents (LACA) at two time points, which were 10 months apart. Prospective associations were obtained for male and female adolescents separately using cross-lagged statistical techniques. Our results showed prospective links between understanding and managing emotions and loneliness for both females and males. Perceiving and using emotions were prospectively linked to loneliness in males only. Possible explanations and directions for future research are discussed.

  3. Business Tourism in Sochi: Issues and Prospects

    OpenAIRE

    Galina M. Romanova; Andrey V. Apukhtin; Lyudmila A. Beloslutseva

    2014-01-01

    The article is devoted to the current problems and pe rspectives of business tourism in Sochi. The development of this segment of tourism may attract extra thousands of tourists. Development prospects of Sochi is associated with the forthcoming tourist boom and reincarnation of this local - popular resort into the international tourist destination. Business tourism is supposed to become an integral part of the...

  4. Organic solvent nanofiltration: prospects and application

    International Nuclear Information System (INIS)

    The key lines of research in a new field of the membrane science and technology, viz., organic solvent nanofiltration, are considered. The prospects for its use in chemical, petrochemical and food industries are discussed. Attention is focused on membranes developed for this method.

  5. Carbohydrate drugs: current status and development prospect.

    Science.gov (United States)

    Zhang, Yan; Wang, Fengshan

    2015-04-01

    In recent years, there has been a great effort devoted to the investigation of the roles of carbohydrates in various essential biological processes and the development of carbohydrates to therapeutic drugs. This review summarizes the carbohydrate drugs which have been recorded in several pharmacopoeias, marketed, and under development. A prospect of the future development of carbohydrate drugs is discussed as well.

  6. A prospective toxicology analysis in alcoholics

    DEFF Research Database (Denmark)

    Thomsen, Jørgen Lange; Simonsen, Kirsten Wiese; Felby, Søren;

    1997-01-01

    A prospective and comprehensive investigation was done on 73 medico–legal autopsies in alcoholics. The results of the toxicology analyses are described. Alcohol intoxication was the cause of death in 8%, combined alcohol/drug intoxication in 15% and drugs alone in 19%. Alcoholic ketoacidosis...

  7. Metamaterial localized resonance sensors: prospects and limitations

    DEFF Research Database (Denmark)

    Jeppesen, Claus; Xiao, Sanshui; Mortensen, Asger;

    2010-01-01

    The prospects and limitations of metamaterial localized resonance sensors are investigated theoretically and experimentally. Gold split-ring resonators are employed as the model system where the light induced LC-resonance yields a figure-of-merit, sensitivity divided by linewidth, up to 54...

  8. Organic solvent nanofiltration: prospects and application

    Energy Technology Data Exchange (ETDEWEB)

    Volkov, A V; Korneeva, G A; Tereshchenko, Gennadii F [A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow (Russian Federation)

    2008-11-30

    The key lines of research in a new field of the membrane science and technology, viz., organic solvent nanofiltration, are considered. The prospects for its use in chemical, petrochemical and food industries are discussed. Attention is focused on membranes developed for this method.

  9. Prospective associations between loneliness and emotional intelligence

    NARCIS (Netherlands)

    Wols, A.; Scholte, R.H.J.; Qualter, P.

    2015-01-01

    Loneliness has been linked cross-sectionally to emotional skill deficits (e.g., Zysberg, 2012), but missing from the literature is a longitudinal examination of these relationships. The present study fills that gap by examining the prospective relationships between loneliness and emotional functioni

  10. Prospective associations between loneliness and emotional intelligence.

    Science.gov (United States)

    Wols, A; Scholte, R H J; Qualter, P

    2015-02-01

    Loneliness has been linked cross-sectionally to emotional skill deficits (e.g., Zysberg, 2012), but missing from the literature is a longitudinal examination of these relationships. The present study fills that gap by examining the prospective relationships between loneliness and emotional functioning in young adolescents in England. One hundred and ninety-six adolescents aged 11-13 years (90 females) took part in the study and completed the youth version of the Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT-YV) and the peer-related subscale of the Loneliness and Aloneness Scale for Children and Adolescents (LACA) at two time points, which were 10 months apart. Prospective associations were obtained for male and female adolescents separately using cross-lagged statistical techniques. Our results showed prospective links between understanding and managing emotions and loneliness for both females and males. Perceiving and using emotions were prospectively linked to loneliness in males only. Possible explanations and directions for future research are discussed. PMID:25576768

  11. Prospective Elementary School Teachers' Proportional Reasoning

    Science.gov (United States)

    Valverde, Gabriela; Castro, Encarnación

    2012-01-01

    We present the findings of a study on prospective elementary teachers' proportional reasoning. After describing some of the teachers' performance in solving multiplicative structure problems that involve ratios and relations of direct proportionality between quantities, we were able to establish classifications of their answers according to…

  12. Contextual Validity in Hybrid Logic

    DEFF Research Database (Denmark)

    Blackburn, Patrick Rowan; Jørgensen, Klaus Frovin

    2013-01-01

    Hybrid tense logic is an extension of Priorean tense logic in which it is possible to refer to times using special propositional sym- bols called nominals. Temporal indexicals are expressions such as now, yesterday, today, tomorrow and four days ago that have highly context- dependent...... interpretations. Moreover, such indexicals give rise to a special kind of validity—contextual validity—that interacts with ordinary logi- cal validity in interesting and often unexpected ways. In this paper we model these interactions by combining standard techniques from hybrid logic with insights from the work...... of Hans Kamp and David Kaplan. We introduce a simple proof rule, which we call the Kamp Rule, and first we show that it is all we need to take us from logical validities involving now to contextual validities involving now too. We then go on to show that this deductive bridge is strong enough to carry us...

  13. Static Validation of XSL Transformations

    DEFF Research Database (Denmark)

    Møller, Anders; Olesen, Mads Østerby; Schwartzbach, Michael Ignatieff

    2007-01-01

    no static guarantees that, under the assumption that the input is valid relative to the input schema, the output of the transformation is valid relative to the output schema. We present a validation technique for XSLT based on the XML graph formalism introduced in the static analysis of JWIG Web services...... and XACT XML transformations. Being able to provide static guarantees, we can detect a large class of errors in an XSLT stylesheet at the time it is written instead of later when it has been deployed, and thereby provide benefits similar to those of static type checkers for modern programming languages....... Our analysis takes a pragmatic approach that focuses its precision on the essential language features but still handles the entire XSLT language. We evaluate the analysis precision on a range of real stylesheets and demonstrate how it may be useful in practice....

  14. Key problems in validation of intelligent models

    Institute of Scientific and Technical Information of China (English)

    LIU Fei; MA Ping; YANG Ming; WANG Zi-cai

    2009-01-01

    To provide a realistic simulation environment for users, intelligent models have become key compo-nents in military simulations. After the analysis of modeling nature of intelligent models, the validation criteria for defining the validation points and validation metrics for measuring the agreements between human expertsand intelligent models were presented. Further, such methods as graphical comparison, feature analysis and face validation were discussed according to the characteristics of intelligent models. Based on the validation cri-teria, validation metrics and validation methods, the intelligent models can be effectively validated, which has been proved in current developed intelligent models.

  15. Opium use and mortality in Golestan Cohort Study: prospective cohort study of 50 000 adults in Iran

    OpenAIRE

    Khademi, Hooman; Malekzadeh, Reza; Pourshams, Akram; Jafari, Elham; Salahi, Rasool; Semnani, Shahryar; Abaie, Behrooz; Islami, Farhad; Nasseri-Moghaddam, Siavosh; Etemadi, Arash; Byrnes, Graham; Abnet, Christian C.; Dawsey, Sanford M.; Day, Nicholas E; Pharoah, Paul D

    2012-01-01

    Objectives To investigate the association between opium use and subsequent risk of death. Design Prospective cohort study. Setting The Golestan Cohort Study in north-eastern Iran collected detailed validated data on opium use and other exposures at baseline. Participants were enrolled between January 2004 and June 2008 and were followed to May 2011, with a follow-up success rate of over 99%. Participants 50 045 participants aged 40-75 at baseline. Main outcomes Mortality, all cause and major ...

  16. Geochemical prospect ion results of Mariscala aerial photo

    International Nuclear Information System (INIS)

    This report shows the geochemical prospect ion results carried out within the framework of the metalical mining prospect ion in Mariscala aerial photo. Lavalleja district belong to the Mining inventory programme of Uruguay.

  17. Validation of New Cancer Biomarkers

    DEFF Research Database (Denmark)

    Duffy, Michael J; Sturgeon, Catherine M; Söletormos, Georg;

    2015-01-01

    in advancing a newly discovered cancer candidate biomarker from pilot studies to clinical application. Four main steps are necessary for a biomarker to reach the clinic: analytical validation of the biomarker assay, clinical validation of the biomarker test, demonstration of clinical value from performance...... of the biomarker test, and regulatory approval. In addition to these 4 steps, all biomarker studies should be reported in a detailed and transparent manner, using previously published checklists and guidelines. Finally, all biomarker studies relating to demonstration of clinical value should be registered before...

  18. Transparent Meta-Analysis of Prospective Memory and Aging

    OpenAIRE

    Bob Uttl

    2008-01-01

    Prospective memory (ProM) refers to our ability to become aware of a previously formed plan at the right time and place. After two decades of research on prospective memory and aging, narrative reviews and summaries have arrived at widely different conclusions. One view is that prospective memory shows large age declines, larger than age declines on retrospective memory (RetM). Another view is that prospective memory is an exception to age declines and remains invariant across the adult lifes...

  19. Whoops, I did it Again: Commission Errors in Prospective Memory

    OpenAIRE

    Scullin, Michael K.; Bugg, Julie M.; McDaniel, Mark A.

    2011-01-01

    Prospective memory research almost exclusively examines remembering to execute an intention, but the ability to forget completed intentions may be similarly important. We had younger and older adults perform a prospective memory task (press Q when you see corn or dancer), and then told them that the intention was completed. Participants later performed a lexical decision task (Phase 2) in which their prospective memory cues reappeared. Initial prospective memory performance was similar betwee...

  20. Memory complaints and prospective memory performance across the lifespan

    OpenAIRE

    Eschen, A; Mattli, F; Sutter, C; Zöllig, J

    2011-01-01

    The frequency of prospective and retrospective memory failures from six age groups was gathered using the Prospective and Retrospective Memory Questionnaire (PRMQ). Objective performance measures were obtained with a laboratory prospective memory task. Findings revealed more prospective than retrospective memory complaints in all age groups except in young children. While overall reported memory failures were similar in the adult groups, fewer failures were reported for the two children group...

  1. Prospective Memory in a Language-Trained Chimpanzee (Pan troglodytes)

    OpenAIRE

    Beran, Michael J.; Perdue, Bonnie M.; Bramlett, Jessica L.; Menzel, Charles R.; Evans, Theodore A.

    2012-01-01

    Prospective memory involves the encoding, retention, and implementation of an intended future action. Although humans show many forms of prospective memory, less is known about the future oriented processes of nonhuman animals, or their ability to use prospective memory. In this experiment, a chimpanzee named Panzee, who had learned to associate geometric forms called lexigrams with real-world referents, was given a prospective memory test. Panzee selected between two foods the one she wanted...

  2. 50 CFR 27.64 - Prospecting and mining.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Prospecting and mining. 27.64 Section 27.64 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR... Property § 27.64 Prospecting and mining. Prospecting, locating, or filing mining claims on...

  3. Predictors of Time-Based Prospective Memory in Children

    Science.gov (United States)

    Mackinlay, Rachael J.; Kliegel, Matthias; Mantyla, Timo

    2009-01-01

    This study identified age differences in time-based prospective memory performance in school-aged children and explored possible cognitive correlates of age-related performance. A total of 56 7- to 12-year-olds performed a prospective memory task in which prospective memory accuracy, ongoing task performance, and time monitoring were assessed.…

  4. Prospective Memory in a Language-Trained Chimpanzee ("Pan Troglodytes")

    Science.gov (United States)

    Beran, Michael J.; Perdue, Bonnie M.; Bramlett, Jessica L.; Menzel, Charles R.; Evans, Theodore A.

    2012-01-01

    Prospective memory involves the encoding, retention, and implementation of an intended future action. Although humans show many forms of prospective memory, less is known about the future oriented processes of nonhuman animals, or their ability to use prospective memory. In this experiment, a chimpanzee named Panzee, who had learned to associate…

  5. A Multinomial Model of Event-Based Prospective Memory

    Science.gov (United States)

    Smith, Rebekah E.; Bayen, Ute J.

    2004-01-01

    Prospective memory is remembering to perform an action in the future. The authors introduce the 1st formal model of event-based prospective memory, namely, a multinomial model that includes 2 separate parameters related to prospective memory processes. The 1st measures preparatory attentional processes, and the 2nd measures retrospective memory…

  6. Reversal in China’s Mineral Risk Prospecting Investment Pattern

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    <正>The total size of China’s central and provincial level geological prospecting funds has reached 39.9 billion yuan,which effectively propelled social capital to make investment in mineral resources risk prospecting through cooperation,and reversed the previous pattern that China’s mining risk prospecting totally relied on investment by the state government.

  7. Turkish Prospective Teachers' Understanding and Misunderstanding on Global Warming

    Science.gov (United States)

    Ocal, A.; Kisoglu, M.; Alas, A.; Gurbuz, H.

    2011-01-01

    The key objective of this study is to determine the Turkish elementary prospective teachers' opinions on global warming. It is also aimed to establish prospective teachers' views about the environmental education in Turkish universities. A true-false type scale was administered to 564 prospective teachers from science education, social studies…

  8. The European Food Consumption Validation Project: conclusions and recommendations

    DEFF Research Database (Denmark)

    de Boer, E. J.; Slimani, N.; van 't Veer, P.;

    2011-01-01

    ) the further development of the EPIC-Soft software (the software developed to conduct 24-h dietary recalls (24-HDRs) in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study) and the validation of the 2-day non-consecutive 24-HDR method using EPIC-Soft, (2) defining and investigating...... exposure to potentially hazardous chemicals such as specific flavoring substances. With the developed Multiple Source Method, repeated non-consecutive 24-HDR data in combination with food propensity data can be used to estimate the population distribution of the usual intake by estimating the individual...... usual intakes. Conclusions: The findings provide sufficient evidence to conclude that the repeated 24-HDR using EPIC-Soft for standardization in combination with a food propensity questionnaire and modeling of usual intake is a suitable method for pan-European surveillance of nutritional adequacy...

  9. Static Validation of Security Protocols

    DEFF Research Database (Denmark)

    Bodei, Chiara; Buchholtz, Mikael; Degano, P.;

    2005-01-01

    We methodically expand protocol narrations into terms of a process algebra in order to specify some of the checks that need to be made in a protocol. We then apply static analysis technology to develop an automatic validation procedure for protocols. Finally, we demonstrate that these techniques...

  10. Assessment of juveniles testimonies’ validity

    Directory of Open Access Journals (Sweden)

    Dozortseva E.G.

    2015-12-01

    Full Text Available The article presents a review of the English language publications concerning the history and the current state of differential psychological assessment of validity of testimonies produced by child and adolescent victims of crimes. The topicality of the problem in Russia is high due to the tendency of Russian specialists to use methodical means and instruments developed abroad in this sphere for forensic assessments of witness testimony veracity. A system of Statement Validity Analysis (SVA by means of Criteria-Based Content Analysis (CBCA and Validity Checklist is described. The results of laboratory and field studies of validity of CBCA criteria on the basis of child and adult witnesses are discussed. The data display a good differentiating capacity of the method, however, a high level of error probability. The researchers recommend implementation of SVA in the criminal investigation process, but not in the forensic assessment. New perspective developments in the field of methods for differentiation of witness statements based on the real experience and fictional are noted. The conclusion is drawn that empirical studies and a special work for adaptation and development of new approaches should precede their implementation into Russian criminal investigation and forensic assessment practice

  11. Validation process of simulation model

    International Nuclear Information System (INIS)

    It is presented a methodology on empirical validation about any detailed simulation model. This king of validation it is always related with an experimental case. The empirical validation has a residual sense, because the conclusions are based on comparisons between simulated outputs and experimental measurements. This methodology will guide us to detect the fails of the simulation model. Furthermore, it can be used a guide in the design of posterior experiments. Three steps can be well differentiated: Sensitivity analysis. It can be made with a DSA, differential sensitivity analysis, and with a MCSA, Monte-Carlo sensitivity analysis. Looking the optimal domains of the input parameters. It has been developed a procedure based on the Monte-Carlo methods and Cluster techniques, to find the optimal domains of these parameters. Residual analysis. This analysis has been made on the time domain and on the frequency domain, it has been used the correlation analysis and spectral analysis. As application of this methodology, it is presented the validation carried out on a thermal simulation model on buildings, Esp., studying the behavior of building components on a Test Cell of LECE of CIEMAT. (Author) 17 refs

  12. Validity of Management Control Topoi

    DEFF Research Database (Denmark)

    Nørreklit, Lennart; Nørreklit, Hanne; Israelsen, Poul

    2004-01-01

    The validity of research and company topoi for constructing/analyzing relaity is analyzed as the integration of the four aspects (dimensions): fact, possibility (logic), value and comunication. Main stream, agency theory and social constructivism are critizied for reductivism (incomplete integrat...

  13. Generalization of Selection Test Validity.

    Science.gov (United States)

    Colbert, G. A.; Taylor, L. R.

    1978-01-01

    This is part three of a three-part series concerned with the empirical development of homogeneous families of insurance company jobs based on data from the Position Analysis Questionnaire (PAQ). This part involves validity generalizations within the job families which resulted from the previous research. (Editor/RK)

  14. Testing and validating environmental models

    Science.gov (United States)

    Kirchner, J.W.; Hooper, R.P.; Kendall, C.; Neal, C.; Leavesley, G.

    1996-01-01

    Generally accepted standards for testing and validating ecosystem models would benefit both modellers and model users. Universally applicable test procedures are difficult to prescribe, given the diversity of modelling approaches and the many uses for models. However, the generally accepted scientific principles of documentation and disclosure provide a useful framework for devising general standards for model evaluation. Adequately documenting model tests requires explicit performance criteria, and explicit benchmarks against which model performance is compared. A model's validity, reliability, and accuracy can be most meaningfully judged by explicit comparison against the available alternatives. In contrast, current practice is often characterized by vague, subjective claims that model predictions show 'acceptable' agreement with data; such claims provide little basis for choosing among alternative models. Strict model tests (those that invalid models are unlikely to pass) are the only ones capable of convincing rational skeptics that a model is probably valid. However, 'false positive' rates as low as 10% can substantially erode the power of validation tests, making them insufficiently strict to convince rational skeptics. Validation tests are often undermined by excessive parameter calibration and overuse of ad hoc model features. Tests are often also divorced from the conditions under which a model will be used, particularly when it is designed to forecast beyond the range of historical experience. In such situations, data from laboratory and field manipulation experiments can provide particularly effective tests, because one can create experimental conditions quite different from historical data, and because experimental data can provide a more precisely defined 'target' for the model to hit. We present a simple demonstration showing that the two most common methods for comparing model predictions to environmental time series (plotting model time series

  15. SMOS Measurements Preliminary Validation: Objectives and Approach

    Science.gov (United States)

    Sabia, Roberto; Gourrion, Jerome; Gabarró, Carolina; Talone, Marco; Portabella, Marcos; Ballabrera, Joaquim; Lopez de Aretxabaleta, Alfredo; Camps, Adriano; Monerris, Alessandra; Font, Jordi

    2010-05-01

    strategy to mitigate the scene-dependent bias found in the SMOS measurements. The comparison of TB departures distributions will be performed within specific classes, aiming at reducing the degrees of freedom of the measurement. Namely, the data will be sorted according to the incidence angle, the wind speed, the across-track distance, the radiometric accuracy and the spatial resolution. Concerning SSS, in turn, the proposed activities will involve inter-comparisons with various external salinity sources. As a further classification, external sources can be distinguished into data coming from models and data collected in-situ. The validation strategy foresees the comparison of SSS misfit (retrieved SSS minus ground-truth SSS) distributions within specific classes. This will be performed sorting geographical areas (different oceans, different zonal frames) and geophysical conditions (e.g. low/high surface temperature, wind speed and SSS conditions). Specific comparisons with in-situ data coming from oceanographic cruises transects and from VOS (Voluntary Observatory Ships) are foreseen, as well as against moored buoys, profilers, and drifters. These data will be arranged in specific match-up datasets, to properly organize the spatio-temporal collocation of the SMOS and in-situ measurements. The possibility of using model solutions for validation will also be considered. Model data are obtained from hindcast simulations from available prediction systems. Concerning the salinity retrieval inversion scheme, efforts will be devoted to the optimization of both the GMF (Geophysical Model Function) and the minimization cost function. With the increase of data availability, the semi-empirical GMF in the ocean salinity Level 2 operational processor will be improved, in particular the roughness-dependent TB term. The introduction of non-linear relationships in the semi-empirical roughness model is a likely extension of this formulation. The prospective approach is to develop, at a

  16. Constructing validity arguments for test combinations

    NARCIS (Netherlands)

    Wools, Saskia; Eggen, Theo J.H.M.; Béguin, Anton

    2016-01-01

    The argument-based approach to validation has been widely adopted in validation theory. However, this approach aims to validate the intended interpretation and use of a single test or assessment. This article proposes an extension of the argument-based approach for validation of multiple tests. This

  17. Alternative methods in toxicology: pre-validated and validated methods

    OpenAIRE

    Kandárová, Helena; Letašiová, Silvia

    2011-01-01

    The development of alternative methods to animal experimentation has progressed rapidly over the last 20 years. Today, in vitro and in silico methods have an important role in the hazard identification and assessment of toxicology profile of compounds. Advanced alternative methods and their combinations are also used for safety assessment of final products. Several alternative methods, which were scientifically validated and accepted by competent regulatory bodies, can be used for regulatory ...

  18. Validation and Classification of Web Services using Equalization Validation Classification

    Directory of Open Access Journals (Sweden)

    ALAMELU MUTHUKRISHNAN

    2012-12-01

    Full Text Available In the business process world, web services present a managed and middleware to connect huge number of services. Web service transaction is a mechanism to compose services with their desired quality parameters. If enormous transactions occur, the provider could not acquire the accurate data at the correct time. So it is necessary to reduce the overburden of web service t ransactions. In order to reduce the excess of transactions form customers to providers, this paper propose a new method called Equalization Validation Classification. This method introduces a new weight - reducing algorithm called Efficient Trim Down algorit hm to reduce the overburden of the incoming client requests. When this proposed algorithm is compared with Decision tree algorithms of (J48, Random Tree, Random Forest, AD Tree it produces a better accuracy and Validation than the existing algorithms. The proposed trimming method was analyzed with the Decision tree algorithms and the results implementation shows that the ETD algorithm provides better performance in terms of improved accuracy with Effective Validation. Therefore, the proposed method provide s a good gateway to reduce the overburden of the client requests in web services. Moreover analyzing the requests arrived from a vast number of clients and preventing the illegitimate requests save the service provider time

  19. Major Achievements and Prospect of the ATLAS Integral Effect Tests

    Directory of Open Access Journals (Sweden)

    Ki-Yong Choi

    2012-01-01

    Full Text Available A large-scale thermal-hydraulic integral effect test facility, ATLAS (Advanced Thermal-hydraulic Test Loop for Accident Simulation, has been operated by KAERI. The reference plant of ATLAS is the APR1400 (Advanced Power Reactor, 1400 MWe. Since 2007, an extensive series of experimental works were successfully carried out, including large break loss of coolant accident tests, small break loss of coolant accident tests at various break locations, steam generator tube rupture tests, feed line break tests, and steam line break tests. These tests contributed toward an understanding of the unique thermal-hydraulic behavior, resolving the safety-related concerns and providing validation data for evaluation of the safety analysis codes and methodology for the advanced pressurized water reactor, APR1400. Major discoveries and lessons found in the past integral effect tests are summarized in this paper. As the demand for integral effect tests is on the rise due to the active national nuclear R&D program in Korea, the future prospects of the application of the ATLAS facility are also discussed.

  20. Prospective Analysis of Risk for Hypothyroidism after Hemithyroidectomy

    Directory of Open Access Journals (Sweden)

    Virgilijus Beisa

    2015-01-01

    Full Text Available Objectives. To evaluate risk factors and to develop a simple scoring system to grade the risk of postoperative hypothyroidism (PH. Methods. In a controlled prospective study, 109 patients, who underwent hemithyroidectomy for a benign thyroid disease, were followed up for 12 months. The relation between clinical data and PH was analyzed for significance. A risk scoring system based on significant risk factors and clinical implications was developed. Results. The significant risk factors of PH were higher TSH (thyroid-stimulating hormone level and lower ratio of the remaining thyroid weight to the patient’s weight (derived weight index. Based on the log of risk factor, preoperative TSH level greater than 1.4 mU/L was assigned 2 points; 1 point was for 0.8–1.4 mU/L. The derived weight index lower than 0.8 g/kg was assigned 1 point. A risk scoring system was calculated by summing the scores. The incidences of PH were 7.3%, 30.4%, and 69.2% according to the risk scores of 0-1, 2, and 3. Conclusion. Risk factors for PH are higher preoperative TSH level and lower derived weight index. Our developed risk scoring system is a valid and reliable tool to identify patients who are at risk for PH before surgery.

  1. Communication-based positioning systems: past, present and prospects

    Institute of Scientific and Technical Information of China (English)

    Guan-Yi Ma; Qing-Tao Wan; Tong Gan

    2012-01-01

    This paper reviews positioning systems in the context of communication systems.First,the basic positioning technique is described for location based service (LBS) in mobile communication systems.Then the high integrity global positioning system (iGPS) is introduced in terms of aspects of what it is and how the low Earth orbit (LEO) Iridium telecommunication satellites enhance the global positioning system (GPS).Emphasis is on the Chinese Area Positioning System (CAPS) which is mainly based on commercial geostationary (GEO) communication satellites,including decommissioned GEO and inclined geosynchronous communication satellites.Characterized by its low cost,high flexibility,wide-area coverage and ample frequency resources,a distinctive feature of CAPS is that its navigation messages are generated on the ground,then uploaded to and forwarded by the communication satellites.Fundamental principles and key technologies applied in the construction of CAPS are presented in detail from the CAPS validation phase to its experimental system setup.A prospective view of CAPS has concluded it to be a seamless,high accuracy,large capacity navigation and communication system which can be achieved by expanding it world wide and enhancing it with LEO satellites and mobile base stations.Hence,this system is a potential candidate for the next generation of radio navigation after GPS.

  2. Communication-based positioning systems: past, present and prospects

    Science.gov (United States)

    Ma, Guan-Yi; Wan, Qing-Tao; Gan, Tong

    2012-06-01

    This paper reviews positioning systems in the context of communication systems. First, the basic positioning technique is described for location based service (LBS) in mobile communication systems. Then the high integrity global positioning system (iGPS) is introduced in terms of aspects of what it is and how the low Earth orbit (LEO) Iridium telecommunication satellites enhance the global positioning system (GPS). Emphasis is on the Chinese Area Positioning System (CAPS) which is mainly based on commercial geostationary (GEO) communication satellites, including decommissioned GEO and inclined geosynchronous communication satellites. Characterized by its low cost, high flexibility, wide-area coverage and ample frequency resources, a distinctive feature of CAPS is that its navigation messages are generated on the ground, then uploaded to and forwarded by the communication satellites. Fundamental principles and key technologies applied in the construction of CAPS are presented in detail from the CAPS validation phase to its experimental system setup. A prospective view of CAPS has concluded it to be a seamless, high accuracy, large capacity navigation and communication system which can be achieved by expanding it world wide and enhancing it with LEO satellites and mobile base stations. Hence, this system is a potential candidate for the next generation of radio navigation after GPS.

  3. A Review of Water Isotopes in Atmospheric General Circulation Models: Recent Advances and Future Prospects

    Directory of Open Access Journals (Sweden)

    Xi Xi

    2014-01-01

    Full Text Available Stable water isotopologues, mainly 1H2O, 1H2HO (HDO, and H12O18, are useful tracers for processes in the global hydrological cycle. The incorporation of water isotopes into Atmospheric General Circulation Models (AGCMs since 1984 has helped scientists gain substantial new insights into our present and past climate. In recent years, there have been several significant advances in water isotopes modeling in AGCMs. This paper reviews and synthesizes key advances accomplished in modeling (1 surface evaporation, (2 condensation, (3 supersaturation, (4 postcondensation processes, (5 vertical distribution of water isotopes, and (6 spatial δ18O-temperature slope and utilizing (1 spectral nudging technique, (2 higher model resolutions, and (3 coupled atmosphere-ocean models. It also reviews model validation through comparisons of model outputs and ground-based and spaceborne measurements. In the end, it identifies knowledge gaps and discusses future prospects of modeling and model validation.

  4. JaqEngine Model Validation

    Energy Technology Data Exchange (ETDEWEB)

    Rademakers, C.

    2009-03-15

    The JaqEngine is a concept engine. It runs on the two stroke internal combustion principle, but is based on an uncommon piston setup and a unique mechanical conversion system. The design of the current prototype of the JaqEngine is (partially) based on two thermodynamic models: A numeric combustion cycle (NCC) model and a computational fluid dynamics (CFD) model. The NCC model simulates multiple combustion cycles and determines global parameters such as cylinder pressure, engine power and overall efficiency. The CFD model simulates the turbulent flow of gasses running through the engine. It provides more detailed information at the cost of increased computational demands. Changes made to the design of the JaqEngine are based on the results of these thermodynamic models. To ensure their results are accurate and reliable, the models need to be validated. Validation consists of checking the input, the used modelling density (e.g. step size or grid size), the working principles of the various components and the implementation of the underlying physical phenomena. After the models are functionally validated they can be verified and corrected using real life data. Eventually the thermodynamics models are a valuable component during redesigning prototypes and programming the engine management system. This report covers the validation of both thermodynamic models of the JaqEngine. The characteristics of the JaqEngine, its benefits and its disadvantages are summed up, with special attention to the usability of the thermodynamic models. The NCC model is rewritten into a more practical format and each component is individually analyzed and checked. The stability and grid quality of the CFD model are investigated and the solver is validated using a backward facing step. Also the usability of the CFD model is investigated by analyzing the performance of the ports and manifolds. In the final part of the report the requirements and setup of the engine test bed is given along with

  5. Methodology for Validating Building Energy Analysis Simulations

    Energy Technology Data Exchange (ETDEWEB)

    Judkoff, R.; Wortman, D.; O' Doherty, B.; Burch, J.

    2008-04-01

    The objective of this report was to develop a validation methodology for building energy analysis simulations, collect high-quality, unambiguous empirical data for validation, and apply the validation methodology to the DOE-2.1, BLAST-2MRT, BLAST-3.0, DEROB-3, DEROB-4, and SUNCAT 2.4 computer programs. This report covers background information, literature survey, validation methodology, comparative studies, analytical verification, empirical validation, comparative evaluation of codes, and conclusions.

  6. Prospect theory, reference points, and health decisions

    Directory of Open Access Journals (Sweden)

    Alan Schwartz

    2008-02-01

    Full Text Available In preventative health decisions, such as the decision to undergo an invasive screening test or treatment, people may be deterred from selecting the test because its perceived disutility relative to not testing is greater than the utility associated with prevention of possible disease. The prospect theory editing operation, by which a decision maker's reference point is determined, can have important effects on the disutility of the test. On the basis of the prospect theory value function, this paper develops two approaches to reducing disutility by directing the decision maker's attention to either (actual past or (expected future losses that result in shifted reference points. After providing a graphical description of the approaches and a mathematical proof of the direction of their effect on judgment, we briefly illustrate the potential value of these approaches with examples from qualitative research on prostate cancer treatment decisions.

  7. Renewable Energy: Markets and Prospects by Technology

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    This information paper accompanies the IEA publication Deploying Renewables 2011: Best and Future Policy Practice (IEA, 2011a). It provides more detailed data and analysis, and explores the markets, policies and prospects for a number of renewable energy technologies. This paper provides a discussion of ten technology areas: bioenergy for electricity and heat, biofuels, geothermal energy, hydro energy, ocean energy, solar energy (solar photovoltaics, concentrating solar power, and solar heating), and wind energy (onshore and offshore). Each technology discussion includes: the current technical and market status; the current costs of energy production and cost trends; the policy environment; the potential and projections for the future; and an analysis of the prospects and key hurdles to future expansion.

  8. Prospect of MH-Ni Batteries Development

    Institute of Scientific and Technical Information of China (English)

    Xu Shaoping; Xing Zhiqiang; Liang Wanlong; Ma Yijun

    2004-01-01

    The development trend and promising application prospects of high-power MH-Ni battery were reviewed by studying and comparing the current high-power batteries research area.High-power MH-Ni batiery has good performlife with 500 ~ 1000 times, abundant material resource, especially abundant rare earth resource in China, high-rate discharging, rapid charging, good safety as well as no pollution, etc., which is regarded as the most promising storage battery for electric vehicles.The performance of high power MH-Ni battery can be brought into play fully and ensure electric vehicles performance if it is equipped with appropriate chargers, controlling system and electric motors.Facing opportunities and challenges, MH-Ni battery has promising application prospects on hybrid electric automobile, electric bicycle and a variety of small sized electric vehicles by improving its technology constantly and developing market actively.

  9. Apathy and Prospective Memory in Aging

    Directory of Open Access Journals (Sweden)

    Fabienne Esposito

    2012-11-01

    Full Text Available Background: Apathy is common in aging, but the processes underlying its different components are still unclear. The aim of this study was to examine the relationships between apathy and prospective memory (PM, a process involved in the execution of delayed intentions. Methods: Fifty elderly participants completed a PM task and a working memory task. Close relatives of the participants were given the Apathy Inventory, which assesses three dimensions of apathy (lack of initiative, lack of interest, emotional blunting, and a negative mood scale. Results: Correlation analyses showed strong relationships between PM and lack of initiative and interest. These relations remain significant even after controlling for global cognitive functioning, working memory, processing speed and negative mood. Conclusion: This study sheds new light on the cognitive mechanisms associated with apathy in aging and opens up interesting prospects for psychological intervention.

  10. A prospective study of gentamicin ototoxicity

    DEFF Research Database (Denmark)

    Winkel, O; Hansen, M M; Kaaber-Bühler, Søren;

    1978-01-01

    Twenty patients were included in a prospective otoneurological study performed to assess the ototoxicity in gentamicin therapy. Gentamicin was administered intravenously, and the serum level was currently determined. Audiographic and electronystagmographic studies were carried out at the institut......Twenty patients were included in a prospective otoneurological study performed to assess the ototoxicity in gentamicin therapy. Gentamicin was administered intravenously, and the serum level was currently determined. Audiographic and electronystagmographic studies were carried out...... at the institution and discontinuation of the treatment and again a few weeks later. Ten patients exhibited ototoxic actions, predominantly cochlear, 4 of the cases being fully reversible. Two patients developed severe hearing loss, associated in one with bilateral extinction of vestibular function. Low serum levels...

  11. Transparent meta-analysis of prospective memory and aging.

    Directory of Open Access Journals (Sweden)

    Bob Uttl

    Full Text Available Prospective memory (ProM refers to our ability to become aware of a previously formed plan at the right time and place. After two decades of research on prospective memory and aging, narrative reviews and summaries have arrived at widely different conclusions. One view is that prospective memory shows large age declines, larger than age declines on retrospective memory (RetM. Another view is that prospective memory is an exception to age declines and remains invariant across the adult lifespan. The present meta-analysis of over twenty years of research settles this controversy. It shows that prospective memory declines with aging and that the magnitude of age decline varies by prospective memory subdomain (vigilance, prospective memory proper, habitual prospective memory as well as test setting (laboratory, natural. Moreover, this meta-analysis demonstrates that previous claims of no age declines in prospective memory are artifacts of methodological and conceptual issues afflicting prior research including widespread ceiling effects, low statistical power, age confounds, and failure to distinguish between various subdomains of prospective memory (e.g., vigilance and prospective memory proper.

  12. Prospects in MPGDs development for neutron detection

    OpenAIRE

    Guerard, Bruno; Hall-Wilton, Richard; Murtas, Fabrizio

    2016-01-01

    Compared to Multi Wires Proportional Chambers (MWPC), Micro-Pattern Gas Detectors (MPGD) used in HEP to detect MIPs offer better spatial resolution, counting rate capability, and radiation hardness; their fabrication is also more reproducible. Provided similar advantages are applicable to detect neutrons, MPGDs might contribute significantly to the development of neutron scientific instrumentation. In order to evaluate the prospects of neutron MPGDs, it is worth knowing the applications which...

  13. Prospect Theory, Mental Accounting, and Momentum

    OpenAIRE

    Mark Grinblatt; Bing Han

    2001-01-01

    The tendency of some investors to hold on to their losing stocks, driven by prospect theory and mental accounting, creates a spread between a stock's fundamental value and its equilibrium price, as well as price underreaction to information. Spread convergence, arising from the random evolution of fundamental values and updating of reference prices, generates predictable equilibrium prices that will be interpreted as possessing momentum. Cross-sectional empirical tests are consistent with the...

  14. The technological prospective of non nuclear channels

    International Nuclear Information System (INIS)

    This prospective study concerns the electric power demand in 2050. It examines the three non nuclear sectors of production: the natural gas combined cycle power plants, the wind turbines among the renewable energies and the cogeneration electric power - heat in the ternary and building sector. The necessity of the network adaptation to the european competition and the decentralized production of electric power will suppose new investments of transport and storage. (A.L.B.)

  15. Human Capital Prospective on Corporate Opportunity Identification

    OpenAIRE

    Koutu, Khushboo

    2012-01-01

    Entrepreneurial activities within firms have been a centre of attraction for researchers in past years. Human capital is yet another unexplored prospective affecting and contributing towards entrepreneurship. To understand how individual operate entrepreneurially within firm, we intend to explore how human capital is developed and how structure and practices in internal and external environment of the firm (in this case focusing on Samsung Electronics Corporation) affects human capital develo...

  16. Automation of electric vehicle and development prospects

    OpenAIRE

    Wen, Wei

    2016-01-01

    This thesis introduces the basic principle of operation for electric vehicle. Through analysing its impact on environment and combining the reality and application, making a prospect concerning electric vehicles’ sales market. In introduction of operative principle for electric vehicle, firstly are all vehicles’ types illustrated. Then through examples, its necessary components and automation control system are explained. In aspect of environment, real explanations and examples are giv...

  17. Prospective analysis. Nuclear deterrence in 2030

    International Nuclear Information System (INIS)

    This study is a prospective analysis of the long-term future of nuclear weapons, and particularly the future of French nuclear deterrence after 2015. The selected time period is 2025-2030. The principal objective is to reflect on what the nuclear world might look like during the first part of the 21 st century, beyond the modernization decisions already planned or envisaged, and to draw conclusions for the future of the French deterrent. (author)

  18. Prospects for Inflationary B-Mode Detection

    Science.gov (United States)

    Kogut, Alan J.

    2011-01-01

    Measurements of the linear polarization of the cosmic microwave background provide a direct window into the physics of inflation. The experimental challenges are daunting: not only is the predicted signal faint compared to the photon noise limit, but it is hidden behind competing foregrounds from both local and cosmic sources. I will discuss the experimental response to these challenges and the prospects for eventual detection and characterization of the inflationary signal.

  19. Growth Prospects in China and India Compared

    OpenAIRE

    Richard Herd; Sean Dougherty

    2007-01-01

    This paper compares the growth prospects of China and India through a growth accounting analysis. Consistent time series for capital stock and employment are constructed using available survey data, and recent revisions to the national accounts for both countries are incorporated. The results allow for a discussion of the sources of growth in both countries, and a consideration of each country's rate of potential growth in light of the outlook for national savings, as demographic shifts occur...

  20. Red flags in prospective contractors' financial statements.

    OpenAIRE

    Lee, Man-ying, Nicole

    1992-01-01

    Approved for public release; distribution is unlimited. This thesis attempts to identify warning signals in the contractors financial statement, or 'red flags', which may be used to identify those prospective contractors who are likely to become delinquent in the performance of their contracts. A 'red flags' list compiled from the current literature was sent to financial analysts in the thirty-eight Financial Service Branches, Defense Contract Management Command Area Offices(FSDCMAOs) to d...

  1. A Review and Prospect on Herbicide Adjuvants

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    The history, present status and future prospects of adjuvants application in herbicides were briefly reviewed. Adjuvants can be separated into two groups, activator adjuvants and utility adjuvants. The former directly enhances the efficacy of a herbicide through increasement of herbicide absorption, spreading, cuticular penetration, rainfastness and retention enhancement, and photodegradation of the herbicide can also be decreased. And the latter is utilized for improving application characteristics, behaviors and physical properties of herbicides and reducing or minimizing unwanted side effects on application.

  2. Radioactivity prospecting with plastic scintillator detector

    International Nuclear Information System (INIS)

    A location of buried fault is of particular concern for the development of groundwater resources in the rocky mountainous areas because groundwater tend to occur around the fault. The gamma-ray radioactivity prospecting with the NaI detector is one of tools to detect the location of buried fault and was successful in some regions. However, few studies on the relationships between the fault, groundwater, and the gamma-ray were reported. The buried fault in the dam-site where the surface soil was stripped showed that many springs were observed along the fissures in granodiorite of CM and CH levels on the both sides of the main fault zone. The radioactivity prospecting across the main fault zone showed that 214Bi and 214Bi/208Tl decrease over the main fault zone. These phenomena are interpreted as the leaching of the uranium. The fluctuation of 222Rn concentration showed the peak at the point near the f1 fault. 222Rn concentration over the areas of springs showed the low concentration. The high 222Rn concentration did not have any influence on 214Bi and 214Bi/208Tl. Our results request the rethinking of the current principle of the gamma-ray radioactivity prospecting that the reason of high 214Bi is caused by upward 222Rn along the open cracks in fault zone. The NaI detector for the radioactivity prospecting is heavy and expensive. PS detector is lightweight and inexpensive compared with NaI detectors. In order to make a large-scale detector with low price, a three-layered PS detector has been developed. Experiments show that the PS detector can discriminate the energies of gamma-rays. (author)

  3. Prospects for Asymmetric PNe with ALMA

    CERN Document Server

    Huggins, P J

    2010-01-01

    Millimeter and sub-millimeter observations have made fundamental contributions to our current understanding of the transition from AGB stars to white dwarfs. The approaching era of ALMA brings significantly enhanced observing capabilities at these wavelengths and promises to push back the frontiers in a number of ways. We examine the scientific prospects of this new era for PNe, with an emphasis on how developments may contribute to the goals of the asymmetric PNe community.

  4. Viewpoint: Canadian competition policy: progress and prospects

    OpenAIRE

    Thomas Ross

    2004-01-01

    This paper discusses the state of competition policy - in particular the economics of competition policy - in Canada today and considers its prospects going forward. It argues that: (i) the importance of competition policy has become accepted widely in Canada and indeed throughout much of the world; (ii) competition policy design and enforcement is in general well done in Canada; (iii) economists, including many Canadians, have played a central role in the development of an efficient and effe...

  5. Examining Media Literacy Levels of Prospective Teachers

    Directory of Open Access Journals (Sweden)

    Taskın INAN

    2012-04-01

    Full Text Available As in many other countries, following the 2007-2008 education year when media literacy courses began to be included in the curricula, media literacy has become one of the discussion topics among educators and decision makers in Turkey. Discussion topics related to media literacy have included who is going to give the media literacy courses, what qualifications will be sought out in media literacy education teachers, what will be included in the media literacy curriculum in terms of its content, and at what level the media literacy course will be given. The current study which aims to examine media literacy levels of prospective teachers utilized thesurvey method. The sample of the study included prospective teachers (480 attending Elementary School Education, Social Studies Education and Turkish Language Education departments in the Education Faculty at the Dumlupinar University in the 2008-2009 education year. The results of the study showed that prospective teachers have a low level of reaction to media messages, do not educate people around enough about the effects of media, but make use of different sources of media to gain information, and are cognizant of media literacy.

  6. Asteroids. Prospective energy and material resources

    Energy Technology Data Exchange (ETDEWEB)

    Badescu, Viorel (ed.) [Bucharest Polytechnic Univ. (Romania). Candida Oancea Institute

    2013-11-01

    Recent research on Prospective Energy and Material Resources on Asteroids. Carefully edited book dedicated to Asteroids prospective energy and material resources. Written by leading experts in the field. The Earth has limited material and energy resources while these resources in space are virtually unlimited. Further development of humanity will require going beyond our planet and exploring of extraterrestrial resources and sources of unlimited power. Thus far, all missions to asteroids have been motivated by scientific exploration. However, given recent advancements in various space technologies, mining asteroids for resources is becoming ever more feasible. A significant portion of asteroids value is derived from their location; the required resources do not need to be lifted at a great expense from the surface of the Earth. Resources derived from Asteroid not only can be brought back to Earth but could also be used to sustain human exploration of space and permanent settlements in space. This book investigates asteroids' prospective energy and material resources. It is a collection of topics related to asteroid exploration, and utilization. It presents past and future technologies and solutions to old problems that could become reality in our life time. The book therefore is a great source of condensed information for specialists involved in current and impending asteroid-related activities and a good starting point for space researchers, inventors, technologists and potential investors. Written for researchers, engineers, and businessmen interested in asteroids' exploration and exploitation.

  7. Drive: Theory and Construct Validation.

    Science.gov (United States)

    Siegling, Alex B; Petrides, K V

    2016-01-01

    This article explicates the theory of drive and describes the development and validation of two measures. A representative set of drive facets was derived from an extensive corpus of human attributes (Study 1). Operationalised using an International Personality Item Pool version (the Drive:IPIP), a three-factor model was extracted from the facets in two samples and confirmed on a third sample (Study 2). The multi-item IPIP measure showed congruence with a short form, based on single-item ratings of the facets, and both demonstrated cross-informant reliability. Evidence also supported the measures' convergent, discriminant, concurrent, and incremental validity (Study 3). Based on very promising findings, the authors hope to initiate a stream of research in what is argued to be a rather neglected niche of individual differences and non-cognitive assessment.

  8. Critical validation studies of neurofeedback.

    Science.gov (United States)

    Gruzelier, John; Egner, Tobias

    2005-01-01

    The field of neurofeedback training has proceeded largely without validation. In this article the authors review studies directed at validating sensory motor rhythm, beta and alpha-theta protocols for improving attention, memory, and music performance in healthy participants. Importantly, benefits were demonstrable with cognitive and neurophysiologic measures that were predicted on the basis of regression models of learning to enhance sensory motor rhythm and beta activity. The first evidence of operant control over the alpha-theta ratio is provided, together with remarkable improvements in artistic aspects of music performance equivalent to two class grades in conservatory students. These are initial steps in providing a much needed scientific basis to neurofeedback. PMID:15564053

  9. Drive: Theory and Construct Validation.

    Science.gov (United States)

    Siegling, Alex B; Petrides, K V

    2016-01-01

    This article explicates the theory of drive and describes the development and validation of two measures. A representative set of drive facets was derived from an extensive corpus of human attributes (Study 1). Operationalised using an International Personality Item Pool version (the Drive:IPIP), a three-factor model was extracted from the facets in two samples and confirmed on a third sample (Study 2). The multi-item IPIP measure showed congruence with a short form, based on single-item ratings of the facets, and both demonstrated cross-informant reliability. Evidence also supported the measures' convergent, discriminant, concurrent, and incremental validity (Study 3). Based on very promising findings, the authors hope to initiate a stream of research in what is argued to be a rather neglected niche of individual differences and non-cognitive assessment. PMID:27409773

  10. Satellite stratospheric aerosol measurement validation

    Science.gov (United States)

    Russell, P. B.; Mccormick, M. P.

    1984-01-01

    The validity of the stratospheric aerosol measurements made by the satellite sensors SAM II and SAGE was tested by comparing their results with each other and with results obtained by other techniques (lider, dustsonde, filter, and impactor). The latter type of comparison required the development of special techniques that convert the quantity measured by the correlative sensor (e.g. particle backscatter, number, or mass) to that measured by the satellite sensor (extinction) and quantitatively estimate the uncertainty in the conversion process. The results of both types of comparisons show agreement within the measurement and conversion uncertainties. Moreover, the satellite uncertainty is small compared to aerosol natural variability (caused by seasonal changes, volcanoes, sudden warmings, and vortex structure). It was concluded that the satellite measurements are valid.

  11. Automatic Validation of Protocol Narration

    DEFF Research Database (Denmark)

    Bodei, Chiara; Buchholtz, Mikael; Degano, Pierpablo;

    2003-01-01

    We perform a systematic expansion of protocol narrations into terms of a process algebra in order to make precise some of the detailed checks that need to be made in a protocol. We then apply static analysis technology to develop an automatic validation procedure for protocols. Finally, we...... demonstrate that these techniques suffice for identifying a number of authentication flaws in symmetric key protocols such as Needham-Schroeder, Otway-Rees, Yahalom and Andrew Secure RPC....

  12. MODIS Hotspot Validation over Thailand

    OpenAIRE

    Veerachai Tanpipat; Prayoonyong Nuchaiya; Kiyoshi Honda

    2009-01-01

    To ensure remote sensing MODIS hotspot (also known as active fire products or hotspots) quality and precision in forest fire control and management in Thailand, an increased level of confidence is needed. Accuracy assessment of MODIS hotspots utilizing field survey data validation is described. A quantitative evaluation of MODIS hotspot products has been carried out since the 2007 forest fire season. The carefully chosen hotspots were scattered throughout the country and within the protected ...

  13. Jack knifing for semivariogram validation

    Directory of Open Access Journals (Sweden)

    Sidney Rosa Vieira

    2010-01-01

    Full Text Available The semivariogram function fitting is the most important aspect of geostatistics and because of this the model chosen must be validated. Jack knifing may be one the most efficient ways for this validation purpose. The objective of this study was to show the use of the jack knifing technique to validate geostatistical hypothesis and semivariogram models. For that purpose, topographical heights data obtained from six distinct field scales and sampling densities were analyzed. Because the topographical data showed very strong trend for all fields as it was verified by the absence of a sill in the experimental semivariograms, the trend was removed with a trend surface fitted by minimum square deviation. Semivariogram models were fitted with different techniques and the results of the jack knifing with them were compared. The jack knifing parameters analyzed were the intercept, slope and correlation coefficient between measured and estimated values, and the mean and variance of the errors calculated by the difference between measured and estimated values, divided by the square root of the estimation variances. The ideal numbers of neighbors used in each estimation was also studied using the jack knifing procedure. The jack knifing results were useful in the judgment of the adequate models fitted independent of the scale and sampling densities. It was concluded that the manual fitted semivariogram models produced better jack knifing parameters because the user has the freedom to choose a better fit in distinct regions of the semivariogram.

  14. Magnetometry and archaeological prospection in Mexico

    Science.gov (United States)

    Barba Pingarron, L.; Laboratorio de Prospeccion Arqueologica

    2013-05-01

    Luis Barba Laboratorio de Prospección Arqueológica Instituto de Investigaciones Antropológicas Universidad Nacional Autonoma de México The first magnetic survey in archaeological prospection was published in 1958 in the first number of Archaeometry, in Oxford. That article marked the beginning of this applications to archaeology. After that, magnetic field measurements have become one of the most important and popular prospection tools. Its most outstanding characteristic is the speed of survey that allows to cover large areas in short time. As a consequence, it is usually the first approach to study a buried archaeological site. The first attempts in Mexico were carried out in 196. Castillo and Urrutia, among other geophysical techniques, used a magnetometer to study the northern part of the main plaza, zocalo, in Mexico City to locate some stone Aztec sculptures. About the same time Morrison et al. in La Venta pyramid used a magnetometer to measure total magnetic field trying to find a substructure. Some years later Brainer and Coe made a magnetic survey to locate large stone Olmec heads in San Lorenzo Tenochtitlan, Veracruz. Technology development has provided everyday more portable and accurate instruments to measure the magnetic field. The first total magnetic field proton magnetometers were followed by differential magnetometers and more recently gradiometers. Presently, multiple sensor magnetometers are widely used in European archaeology. The trend has been to remove the environmental and modern interference and to make more sensitive the instruments to the superficial anomalies related to most of the archaeological sites. There is a close relationship between the geology of the region and the way magnetometry works in archaeological sites. Archaeological prospection in Europe usually needs very sensitive instruments to detect slight magnetic contrast of ditches in old sediments. In contrast, volcanic conditions in Mexico produce large magnetic contrast

  15. SMAP RADAR Calibration and Validation

    Science.gov (United States)

    West, R. D.; Jaruwatanadilok, S.; Chaubel, M. J.; Spencer, M.; Chan, S. F.; Chen, C. W.; Fore, A.

    2015-12-01

    The Soil Moisture Active Passive (SMAP) mission launched on Jan 31, 2015. The mission employs L-band radar and radiometer measurements to estimate soil moisture with 4% volumetric accuracy at a resolution of 10 km, and freeze-thaw state at a resolution of 1-3 km. Immediately following launch, there was a three month instrument checkout period, followed by six months of level 1 (L1) calibration and validation. In this presentation, we will discuss the calibration and validation activities and results for the L1 radar data. Early SMAP radar data were used to check commanded timing parameters, and to work out issues in the low- and high-resolution radar processors. From April 3-13 the radar collected receive only mode data to conduct a survey of RFI sources. Analysis of the RFI environment led to a preferred operating frequency. The RFI survey data were also used to validate noise subtraction and scaling operations in the radar processors. Normal radar operations resumed on April 13. All radar data were examined closely for image quality and calibration issues which led to improvements in the radar data products for the beta release at the end of July. Radar data were used to determine and correct for small biases in the reported spacecraft attitude. Geo-location was validated against coastline positions and the known positions of corner reflectors. Residual errors at the time of the beta release are about 350 m. Intra-swath biases in the high-resolution backscatter images are reduced to less than 0.3 dB for all polarizations. Radiometric cross-calibration with Aquarius was performed using areas of the Amazon rain forest. Cross-calibration was also examined using ocean data from the low-resolution processor and comparing with the Aquarius wind model function. Using all a-priori calibration constants provided good results with co-polarized measurements matching to better than 1 dB, and cross-polarized measurements matching to about 1 dB in the beta release. During the

  16. SOFTWARE METRICS VALIDATION METHODOLOGIES IN SOFTWARE ENGINEERING

    Directory of Open Access Journals (Sweden)

    K.P. Srinivasan

    2014-12-01

    Full Text Available In the software measurement validations, assessing the validation of software metrics in software engineering is a very difficult task due to lack of theoretical methodology and empirical methodology [41, 44, 45]. During recent years, there have been a number of researchers addressing the issue of validating software metrics. At present, software metrics are validated theoretically using properties of measures. Further, software measurement plays an important role in understanding and controlling software development practices and products. The major requirement in software measurement is that the measures must represent accurately those attributes they purport to quantify and validation is critical to the success of software measurement. Normally, validation is a collection of analysis and testing activities across the full life cycle and complements the efforts of other quality engineering functions and validation is a critical task in any engineering project. Further, validation objective is to discover defects in a system and assess whether or not the system is useful and usable in operational situation. In the case of software engineering, validation is one of the software engineering disciplines that help build quality into software. The major objective of software validation process is to determine that the software performs its intended functions correctly and provides information about its quality and reliability. This paper discusses the validation methodology, techniques and different properties of measures that are used for software metrics validation. In most cases, theoretical and empirical validations are conducted for software metrics validations in software engineering [1-50].

  17. Integrative analysis to select cancer candidate biomarkers to targeted validation

    Science.gov (United States)

    Heberle, Henry; Domingues, Romênia R.; Granato, Daniela C.; Yokoo, Sami; Canevarolo, Rafael R.; Winck, Flavia V.; Ribeiro, Ana Carolina P.; Brandão, Thaís Bianca; Filgueiras, Paulo R.; Cruz, Karen S. P.; Barbuto, José Alexandre; Poppi, Ronei J.; Minghim, Rosane; Telles, Guilherme P.; Fonseca, Felipe Paiva; Fox, Jay W.; Santos-Silva, Alan R.; Coletta, Ricardo D.; Sherman, Nicholas E.; Paes Leme, Adriana F.

    2015-01-01

    Targeted proteomics has flourished as the method of choice for prospecting for and validating potential candidate biomarkers in many diseases. However, challenges still remain due to the lack of standardized routines that can prioritize a limited number of proteins to be further validated in human samples. To help researchers identify candidate biomarkers that best characterize their samples under study, a well-designed integrative analysis pipeline, comprising MS-based discovery, feature selection methods, clustering techniques, bioinformatic analyses and targeted approaches was performed using discovery-based proteomic data from the secretomes of three classes of human cell lines (carcinoma, melanoma and non-cancerous). Three feature selection algorithms, namely, Beta-binomial, Nearest Shrunken Centroids (NSC), and Support Vector Machine-Recursive Features Elimination (SVM-RFE), indicated a panel of 137 candidate biomarkers for carcinoma and 271 for melanoma, which were differentially abundant between the tumor classes. We further tested the strength of the pipeline in selecting candidate biomarkers by immunoblotting, human tissue microarrays, label-free targeted MS and functional experiments. In conclusion, the proposed integrative analysis was able to pre-qualify and prioritize candidate biomarkers from discovery-based proteomics to targeted MS. PMID:26540631

  18. The validity and reliability of the functional rating index for evaluating low back pain in athletes.

    Science.gov (United States)

    Naghdi, S; Ansari, N Nakhostin; Yazdanpanah, M; Feise, R J; Fakhari, Z

    2015-12-01

    The purpose of the present study was to determine the reliability and validity of the Functional Rating Index (FRI) for athletes with low back pain (LBP). In this cross-sectional and prospective cohort study, the validated Persian FRI (PFRI) was tested in 100 athletes with LBP and 50 healthy athletes. From the athletes with LBP, data were recollected among 50 athletes with a 7-day interval to examine test-retest reliability. The content validity was excellent, and the athletes with LBP responded to all items with no floor or ceiling effects. The discriminative validity was supported by a statistically significant difference in PFRI total scores between the athletes with LBP and healthy athletes. The concurrent criterion validity was good (rho = 0.72). The construct, convergent validity was good (r = 0.83). The internal consistency reliability estimate was high (Cronbach's α = 0.90). Factor analysis demonstrated a single-factor structure with an explained variance of 52.22%. The test-retest reliability was excellent, indicated by an ICC(agreement) of 0.97, and the agreement observed in the Bland and Altman plot demonstrated no systematic bias. It is concluded that the PFRI has excellent psychometric properties for assessing athletes with LBP.

  19. Validation of self-reported folic acid use in a multiethnic population: results of the Amsterdam Born Children and their Development study

    NARCIS (Netherlands)

    J.J. Sikkens; M. van Eijsden; G.J. Bonsel; M.C. Cornel

    2011-01-01

    Objective: To assess folic acid supplementation rates and validate the self-reporting of folic acid supplement use among pregnant women in a multiethnic cohort. Design: Secondary analysis of a prospective cohort study. Setting: Self-reported folic acid supplement use in the Amsterdam Born Children a

  20. Population based external validation of a European predictive model for respiratory syncytial virus hospitalization of premature infants born 33 to 35 weeks of gestational age

    DEFF Research Database (Denmark)

    Stensballe, Lone G; Fullarton, John R; Carbonell-Estrany, Xavier;

    2010-01-01

    Prospectively collected population-based data on 2529 Danish infants born at 33 to 35 weeks of gestation were used to validate an European predictive model of respiratory syncytial virus (RSV) hospitalization. The model was found to be robust with a diagnostic accuracy of 65.9% to distinguish bet...

  1. A clinical decision rule for the use of plain radiography in children after acute wrist injury: development and external validation of the Amsterdam Pediatric Wrist Rules

    NARCIS (Netherlands)

    A. Slaar (Annelie); M.M.J. Walenkamp (Monique); A. Bentohami (Abdelali); M. Maas (Mario); R.R. van Rijn (Rick); E.W. Steyerberg (Ewout); L.C. Jager (L. Cara); N.L. Sosef (Nico L.); R. van Velde (Romuald); J.M. Ultee (Jan); J.C. Goslings (Carel); N.W.L. Schep (Niels)

    2016-01-01

    textabstractBackground: In most hospitals, children with acute wrist trauma are routinely referred for radiography. Objective: To develop and validate a clinical decision rule to decide whether radiography in children with wrist trauma is required. Materials and methods: We prospectively developed a

  2. The Challenges and Prospects of E-learning in National Open University of Nigeria

    Directory of Open Access Journals (Sweden)

    Olukayode Solomon Aboderin

    2015-08-01

    Full Text Available The study investigated the challenges and prospects of e-learning in National Open University of Nigeria. It sought to find out Attitudes of students towards e-learning. The study investigated the various challenges of e-learning in NOUN. Also the studies investigated prospects of e-learning, availability of e-learning facilities and also determine the ICT competence of NOUN students. The design of the study is a descriptive survey type. The sample for the study consisted of 250 students randomly selected from all the faculties in National Open University of Nigeria, Akure Study Center. 50 students were drawn from each faculty using simple random sampling technique giving a total of 250 students (respondents. A questionnaire titled “Challenges and Prospects of E-learning in National Open University of Nigeria” designed by the research was used to collect data. The instrument was validated by expert in Computer Science, Educational Technology and Test and Measurement. To ensure the reliability of the instrument, a Cronbach alpha statistics technique was employed and a reliability coefficient of 0.84 was obtained. This value is high enough for a study of this nature. The data collected were analyzed through the use of descriptive statistics such as frequency count, percentage and bar chart. The result of the findings showed that: NOUN students show positive attitude towards the use of e-learning. Majority of the respondents agreed that NOUN does not have enough e-learning equipment and facilities. There are challenges affecting the utilization of e-learning in NOUN for instructional purposes. The study also revealed that e-exam adopted by NOUN contributes to students’ ICT competence and prospects of e-learning if fully implemented.

  3. Turbulence Modeling Verification and Validation

    Science.gov (United States)

    Rumsey, Christopher L.

    2014-01-01

    Computational fluid dynamics (CFD) software that solves the Reynolds-averaged Navier-Stokes (RANS) equations has been in routine use for more than a quarter of a century. It is currently employed not only for basic research in fluid dynamics, but also for the analysis and design processes in many industries worldwide, including aerospace, automotive, power generation, chemical manufacturing, polymer processing, and petroleum exploration. A key feature of RANS CFD is the turbulence model. Because the RANS equations are unclosed, a model is necessary to describe the effects of the turbulence on the mean flow, through the Reynolds stress terms. The turbulence model is one of the largest sources of uncertainty in RANS CFD, and most models are known to be flawed in one way or another. Alternative methods such as direct numerical simulations (DNS) and large eddy simulations (LES) rely less on modeling and hence include more physics than RANS. In DNS all turbulent scales are resolved, and in LES the large scales are resolved and the effects of the smallest turbulence scales are modeled. However, both DNS and LES are too expensive for most routine industrial usage on today's computers. Hybrid RANS-LES, which blends RANS near walls with LES away from walls, helps to moderate the cost while still retaining some of the scale-resolving capability of LES, but for some applications it can still be too expensive. Even considering its associated uncertainties, RANS turbulence modeling has proved to be very useful for a wide variety of applications. For example, in the aerospace field, many RANS models are considered to be reliable for computing attached flows. However, existing turbulence models are known to be inaccurate for many flows involving separation. Research has been ongoing for decades in an attempt to improve turbulence models for separated and other nonequilibrium flows. When developing or improving turbulence models, both verification and validation are important

  4. Potential Prospects of Turkey in Africa

    OpenAIRE

    Gorgulu, Mehmet Emre

    2010-01-01

    As the global crisis surrounds us, Turkey, as a country with huge prospects, needs to establish new political and commercial links with the rest of the world in order to lessen the effects of the global crisis. This can be a way to take the load off Turkey’s shoulders. These links can be found in the continent Africa. As the host of world’s several fastest growing economies, the continent offers new opportunities for Turkey. These opportunities can be utilized as either in the form of Foreign...

  5. Prospects For China's Expendable Launch Vehicle

    Institute of Scientific and Technical Information of China (English)

    Long Lehao; Wang Xiaojun; Rong Yi

    2009-01-01

    @@ The expendable launch vehicle ( ELV) is the major means for human beings to enter space. Up until April 2009, China's Long March (LM) series launch vehicle has conducted 117 launches, and realized 75 consecutive successful launches since October 1996, which marks China's ELV development has entered a new historical era. Based on the analysis of China's LM series launch vehicle development status, combining with the new generation launch vehicle development, this raises a development prospect for China's ELV to meet the demands for future launch vehicle technology development.

  6. Application of solar chargers to prospection instruments

    International Nuclear Information System (INIS)

    The use of conventional batteries has certain disadvantages, and for this reason high-voltage batteries have been gradually replaced in all prospection instruments by transistor supply systems, using less cumbersome sources of energy. All the same low voltages are still necessary, and in hot or damp countries the use of these batteries leads to consumptions out of all proportion to the services rendered. This is why the use of solar energy possesses real advantages. After a brief review of the basic ideas on semiconductors, this article describes a selenium solar battery which was developed by the Westinghouse brakes and signals society. (author)

  7. Geologic formation prospect of uranium Irian Jaya

    International Nuclear Information System (INIS)

    This paper was resulted from compilation of regional geologic mapping and uranium prospection in which it was considered in making exploration program. Method used was literary study of geologic information which was connected with uranium deposit occurrence. From the 26 formations identified as a formation based on physical characteristics and U grade in stream sediments and rocks, there were 2 specific formation groups which were good enough to be dealt in exploration program that is Kemblangan Group and Aifam Group. (author); 8 refs; 4 figs

  8. Detection Prospects of the Cosmic Neutrino Background

    CERN Document Server

    Li, Yu-Feng

    2015-01-01

    The existence of the cosmic neutrino background (CnuB) is a fundamental prediction of the standard Big Bang cosmology. Although current cosmological probes provide indirect observational evidence, the direct detection of the CnuB in a laboratory experiment is a great challenge to the present experimental techniques. We discuss the future prospects for the direct detection of the CnuB, with the emphasis on the method of captures on beta-decaying nuclei and the PTOLEMY project. Other possibilities using the electron-capture (EC) decaying nuclei, the annihilation of extremely high-energy cosmic neutrinos (EHEC\

  9. LOFAR: Recent imaging results & future prospects

    CERN Document Server

    Heald, George; Horneffer, Andreas; Offringa, André R; Pizzo, Roberto; van der Tol, Sebastiaan; van Weeren, Reinout J; van Zwieten, Joris E; Anderson, James M; Beck, Rainer; van Bemmel, Ilse; Bîrzan, Laura; Bonafede, Annalisa; Conway, John; Ferrari, Chiara; De Gasperin, Francesco; Haverkorn, Marijke; Jackson, Neal; Macario, Giulia; McKean, John; Miraghaei, Halime; Orrù, Emanuela; Rafferty, David; Röttgering, Huub; Scaife, Anna; Shulevski, Aleksandar; Sotomayor, Carlos; Tasse, Cyril; Trasatti, Monica; Wucknitz, Olaf

    2011-01-01

    The Low Frequency Array (LOFAR) is under construction in the Netherlands and in several surrounding European countries. In this contribution, we describe the layout and design of the telescope, with a particular emphasis on the imaging characteristics of the array when used in its "standard imaging" mode. After briefly reviewing the calibration and imaging software used for LOFAR image processing, we show some recent results from the ongoing imaging commissioning efforts. We conclude by summarizing future prospects for the use of LOFAR in observing the little-explored low frequency Universe.

  10. Growth Prospects in China and India Compared

    Directory of Open Access Journals (Sweden)

    Richard Herd

    2007-06-01

    Full Text Available This paper compares the growth prospects of China and India through a growth accounting analysis. Consistent time series for capital stock and employment are constructed using available survey data, and recent revisions to the national accounts for both countries are incorporated. The results allow for a discussion of the sources of growth in both countries, and a consideration of each country’s rate of potential growth in light of the outlook for national savings, as demographic shifts occur in each country

  11. Jiangmen Underground Neutrino Observatory: Status and Prospectives

    CERN Document Server

    Li, Yu-Feng

    2016-01-01

    The Jiangmen Underground Neutrino Observatory (JUNO) is a 20 kton liquid scintillator (LS) detector, which is planed to determine the neutrino mass hierarchy and measure the oscillation parameters at the sub-percent level using reactor antineutrino oscillations. As a multipurpose neutrino experiment, JUNO is also capable of measuring supernova burst neutrinos, the diffuse supernova neutrino background, geo-neutrinos, solar neutrinos and atmospheric neutrinos. After a brief introduction to the physics motivation, we discuss the status of the JUNO project, including the design of the detector systems. Finally the latest civil progress and future prospectives are also highlighted.

  12. A Prospect of Earthquake Prediction Research

    CERN Document Server

    Ogata, Yosihiko

    2013-01-01

    Earthquakes occur because of abrupt slips on faults due to accumulated stress in the Earth's crust. Because most of these faults and their mechanisms are not readily apparent, deterministic earthquake prediction is difficult. For effective prediction, complex conditions and uncertain elements must be considered, which necessitates stochastic prediction. In particular, a large amount of uncertainty lies in identifying whether abnormal phenomena are precursors to large earthquakes, as well as in assigning urgency to the earthquake. Any discovery of potentially useful information for earthquake prediction is incomplete unless quantitative modeling of risk is considered. Therefore, this manuscript describes the prospect of earthquake predictability research to realize practical operational forecasting in the near future.

  13. LOFAR: Recent Imaging Results and Future Prospects

    Indian Academy of Sciences (India)

    George Heald; Michael R. Bell; Andreas Horneffer; André R. Offringa; Roberto Pizzo; Sebastiaan van der Tol; Reinout J. van Weeren; Joris E. van Zwieten; James M. Anderson; Rainer Beck; Ilse van Bemmel; Laura Bîrzan; Annalisa Bonafede; John Conway; Chiara Ferrari; Francesco De Gasperin; Marijke Haverkorn; Neal Jackson; Giulia Macario; John McKean; Halime Miraghaei; Emanuela Orrù; David Rafferty; Huub Röttgering; Anna Scaife; Aleksandar Shulevski; Carlos Sotomayor; Cyril Tasse; Monica Trasatti; Olaf Wucknitz

    2011-12-01

    The Low-Frequency Array (LOFAR) is under construction in the Netherlands and in several surrounding European countries. In this contribution, we describe the layout and design of the telescope, with particular emphasis on the imaging characteristics of the array when used in its `standard imaging’ mode. After briefly reviewing the calibration and imaging software used for LOFAR image processing, we show some recent results from the ongoing imaging commissioning efforts. We conclude by summarizing future prospects for the use of LOFAR in observing the little-explored low-frequency Universe.

  14. Future Prospects at Electron-Positron Machines

    CERN Document Server

    Roney, J Michael

    2013-01-01

    This review will present the future prospects for physics at electron-positron colliders running near the Upsilon(4S) as well as at the charm and tau thresholds. It includes a review of the Belle II and SuperB projects. Also reviewed are the plans for BES III, which operates near the charm threshold at the IHEP BEPC machine in Bejing and the status of the Super Charm/Tau Factory proposed for the Budker Institute for Nuclear Physics (BINP) in Novosibirsk.

  15. LHCb Physics and 2010-11 prospects

    Science.gov (United States)

    Perazzini, Stefano

    2011-10-01

    LHCb is one of the four major experiments operating at the Large Hadron Collider, and is specifically dedicated to the measurement of CP-violation and rare decays in the beauty and charm quark sectors. By employing data from early LHC runs it is possible to assess the performance of the detector and to better understand the potential of the LHCb flavour programme. After a brief introduction of the motivations and of the relevant physics goals, the prospects about key CP-violation and rare decay measurements will be presented. Emphasis will be given to those topics where results with particular sensitivity to New Physics are expected during the 2010-11 run.

  16. MODIS Hotspot Validation over Thailand

    Directory of Open Access Journals (Sweden)

    Veerachai Tanpipat

    2009-11-01

    Full Text Available To ensure remote sensing MODIS hotspot (also known as active fire products or hotspots quality and precision in forest fire control and management in Thailand, an increased level of confidence is needed. Accuracy assessment of MODIS hotspots utilizing field survey data validation is described. A quantitative evaluation of MODIS hotspot products has been carried out since the 2007 forest fire season. The carefully chosen hotspots were scattered throughout the country and within the protected areas of the National Parks and Wildlife Sanctuaries. Three areas were selected as test sites for validation guidelines. Both ground and aerial field surveys were also conducted in this study by the Forest Fire Control Division, National Park, Wildlife and Plant Conversation Department, Ministry of Natural Resources and Environment, Thailand. High accuracy of 91.84 %, 95.60% and 97.53% for the 2007, 2008 and 2009 fire seasons were observed, resulting in increased confidence in the use of MODIS hotspots for forest fire control and management in Thailand.

  17. Career Prospects and Effort Incentives: Evidence from Professional Soccer

    OpenAIRE

    Miklós-Thal, Jeanine; Ullrich, Hannes

    2014-01-01

    It is difficult to empirically test the prediction that future career prospects create implicit efforts incentives because researchers cannot randomly "assign" career prospects to economic agents. To overcome this challenge, we use data from professional soccer, where employees of the same club face different external career opportunities depending on their nationality. We test whether the career prospect of being selected to a Euro Cup national team affects players' pre-Cup performances, usi...

  18. Event-based prospective memory in the rat

    OpenAIRE

    Wilson, A. George; Pizzo, Matthew J; Crystal, Jonathon D.

    2013-01-01

    People plan to act in the future when an appropriate event occurs, a capacity known as event-based prospective memory [1]. Prospective memory involves forming a representation of a planned future action, subsequently inactivating the representation, and ultimately reactivating it at an appropriate point in the future. Recent studies suggest that monkeys, chimpanzees, and rats display elements of prospective memory [2–5], but it is uncertain if the full sequence (activation-inactivation-reacti...

  19. An investigation into prospective memory in children with developmental dyslexia

    OpenAIRE

    Azizuddin eKhan

    2014-01-01

    Developmental dyslexia hinders reading and writing acquisition of around 5-10 % of the children all over the world. However, little is known about role of prospective memory among dyslexics. Prospective memory is realization of delayed intention. Realization of delayed intention requires self initiated process. The present study explored the role of memory (prospective and retrospective memory), meta-memory and attention among dyslexic’s children. One hundred and fifteen children (51 dyslexic...

  20. An investigation into prospective memory in children with developmental dyslexia

    OpenAIRE

    Khan, Azizuddin

    2014-01-01

    Developmental dyslexia hinders reading and writing acquisition of around 5–10% of the children all over the world. However, little is known about role of prospective memory among dyslexics. Prospective memory is realization of delayed intention. Realization of delayed intention requires self initiated process. The present study explored the role of memory (prospective and retrospective memory), meta-memory and attention among dyslexic's children. One hundred and fifteen children (51 dyslexics...

  1. Event-based prospective memory performance in autism spectrum disorder

    OpenAIRE

    Altgassen, Mareike; Schmitz-Hübsch, Maren; Kliegel, Matthias

    2009-01-01

    The purpose of the present study was to investigate event-based prospective memory performance in individuals with autism spectrum disorder and to explore possible relations between laboratory-based prospective memory performance and everyday performance. Nineteen children and adolescents with autism spectrum disorder and 19 matched neurotypical controls participated. The laboratory-based prospective memory test was embedded in a visuo-spatial working memory test and required participants to ...

  2. Prospective teachers’ opinions of argument culture in the classroom environment

    OpenAIRE

    Senar ALKIN-ŞAHİN; Nihan DEMİRKASIMOĞLU

    2015-01-01

    This paper focuses on the opinions of prospective teachers’ related to argument culture in the classroom environment. The data stems from a phenomenological study including 12 prospective teachers attending the education faculty of a Turkish state university for the 2013-2014 academic year. Data collected from focus group interviews were thematically analyzed. Findings indicated that prospective teachers were aware of the pedagogical value of the argument culture. Argument culture was mostly ...

  3. Statistical validity of interleukin-6 as a biomarker for the diagnosis of early-onset neonatal sepsis

    OpenAIRE

    Sriparna Basu; Shashikant Dewangan; Shampa Anupurva; Ashok Kumar

    2012-01-01

    Use of empirical antibiotics in neonates with risk factors of early-onset neonatal sepsis (EOS) is a common practice. A laboratory parameter is needed to help in the accurate diagnosis of EOS to avoid unnecessary use of antibiotics. The aim of this prospective observational cohort study was to compare the statistical validity of cord blood interleukin-6 (IL-6) with conventional sepsis screening as an early diagnostic marker for EOS. Eighty-seven neonates with antenatal risk factors for sepsis...

  4. The Manchester Acute Coronary Syndromes (MACS) decision rule for suspected cardiac chest pain: derivation and external validation

    OpenAIRE

    Body, Richard; Carley, Simon; McDowell, Garry; Pemberton, Philip; Burrows, Gillian; Cook , Gary; Lewis, Philip S; Smith, Alexander; Mackway-Jones, Kevin

    2014-01-01

    Objective We aimed to derive and validate a clinical decision rule (CDR) for suspected cardiac chest pain in the emergency department (ED). Incorporating information available at the time of first presentation, this CDR would effectively risk-stratify patients and immediately identify: (A) patients for whom hospitalisation may be safely avoided; and (B) high-risk patients, facilitating judicious use of resources. Methods In two sequential prospective observational cohort studies at heterogene...

  5. Validation of the Child Sport Cohesion Questionnaire

    Science.gov (United States)

    Martin, Luc J.; Carron, Albert V.; Eys, Mark A.; Loughead, Todd

    2013-01-01

    The purpose of the present study was to test the validity evidence of the Child Sport Cohesion Questionnaire (CSCQ). To accomplish this task, convergent, discriminant, and known-group difference validity were examined, along with factorial validity via confirmatory factor analysis (CFA). Child athletes (N = 290, M[subscript age] = 10.73 plus or…

  6. Cigarette smoking during pregnancy and preeclampsia risk: a systematic review and meta-analysis of prospective studies.

    Science.gov (United States)

    Wei, Jun; Liu, Cai-Xia; Gong, Ting-Ting; Wu, Qi-Jun; Wu, Lang

    2015-12-22

    Although evidence from epidemiological studies evaluating the association between cigarette smoking during pregnancy and preeclampsia risk has been systematically reviewed, the findings have been out of date. To further clarify the relationship, we conducted this comprehensive meta-analysis of prospective studies. We searched PubMed and Web of Science up to August 2015 to identify prospective studies that evaluated the association between cigarette smoking during pregnancy and preeclampsia risk. Random-effects models were used to estimate summarized relative risk (RR) and 95% confidence intervals (CIs). Seventeen prospective studies involving 62,089 preeclampsia patients from a total of approximately 1.8 million subjects were included. Overall, there was a significant negative association between smoking during pregnancy and incidence of preeclampsia (RR = 0.67, 95% CI: 0.60-0.75), with significant heterogeneity (I2 = 91.7%). Such an inverse association was also detected in strata of subgroup analyses according to study location, study sample size, parity of populations, singleton pregnancy, and adjustment for potential confounders including maternal age, diabetes mellitus, chronic hypertension, body mass index, and gender of infant. In summary, this meta-analysis suggests that smoking during pregnancy is inversely associated with incidence of preeclampsia. Further large scale multi-center prospective studies are warranted to validate our findings.

  7. Two prospective dosing methods for nortriptyline.

    Science.gov (United States)

    Perry, P J; Browne, J L; Alexander, B; Tsuang, M T; Sherman, A D; Dunner, F J

    1984-01-01

    This study compared two prospective pharmacokinetic dosing methods to predict steady-state concentrations of nortriptyline. One method required multiple determinations of the nortriptyline plasma concentration to estimate the drug's steady-state concentration. The second method required a single nortriptyline concentration drawn at a fixed time, preferably 36 hours, following a nortriptyline test dose. The 36-hour nortriptyline plasma concentrations (NTP 36h) were substituted into the straight-line equation of Cssav = 17.2 + 3.74 (NTP 36h), where Cssav is the average steady-state concentration for a 100 mg/day dose of nortriptyline. No differences were noted between the observed steady-state nortriptyline concentration of 121 +/- 19 ng/ml, the 36-hour single-point prediction mean concentration of 121 +/- 21 ng/ml, or the multiple-point prediction mean concentration of 122 +/- 19 ng/ml. Because of the similar findings between the two methods, the clinical advantages and disadvantages of each kinetic approach are discussed to put these prospective dosing protocols into their proper perspective.

  8. Development environmental attitude of prospective science teachers

    International Nuclear Information System (INIS)

    Since the last three decades or so, we have witnessed the growing concern of human beings, all over the world, to adopt measures to conserve and preserve environment of the planet earth, because the same has been threatened by human activity and by way of our unparalleled intervention in the otherwise balanced environment. This awareness and concern has emerged as a need of incorporating environmental Issues into the normal curricula, so that we can educate the young generation to become informed decision-makers of the future. UNESCO and UNEP have advocated (since the last three decades) to teach environmentalised science to students. In Pakistan, there have been attempts to change curricula in accordance with the need of the time. Teachers need new kinds of skills, attitudes and commitment to teach science in an environmentalised fashion. This article discusses the impact of a semester-course on change in environmental attitudes of prospective science-teachers. A pre-test, post-test method was used to ascertain any change in environmental attitude of prospective science-teachers, after studying the environmental education course. It has been shown that there was a change in the environmental attitude of science-teachers as a result of the one-semester course, but the change or the level of attitude was not substantial or satisfactory. There seems to be a need of adopting a comprehensive approach to environmental education, and introducing teaching of environmental concepts at a very early age. (author)

  9. Seizures after stroke : a prospective clinical study.

    Directory of Open Access Journals (Sweden)

    Dhanuka A

    2001-01-01

    Full Text Available Stroke is one of the most common causes of epilepsy in elderly. However, there have been very few prospective studies to define the incidence, pattern and outcome of seizures in stroke. Most studies are based on retrospective analysis of hospital records. Hence, we planned this prospective study to see the clinical, radiological and electroencephalographic characteristics of seizures in stroke and their outcome, from a north Indian tertiary care centre. Over a span of approximately 6 years, 269 consecutive patients with stroke were studied and followed up. Thirty-five (13% of these developed seizures, primarily related to stroke, during mean follow up period of 15.9 months. Twenty of these had infarctions while 15 had haemorrhages. Involvement of the cortical region was seen in most of the patients with seizures. In these patients, 86% of the lesions involved cortical areas exclusively or in addition to subcortical areas on CT scan of the brain. Twenty-seven (77% developed early seizures, two third of them had immediate post-stroke seizures. None of the patients with early onset seizures developed recurrent seizures or epilepsy, while 50% of late onset seizures developed epilepsy. No specific EEG pattern was found in those who later developed epilepsy. In the present study, early onset seizures after stroke were rather common and did not affect outcome and did not recur even when not treated with anti-epileptics. Late onset seizures were less common but were associated with recurrent seizures.

  10. Prospective study of definite caterpillar exposures.

    Science.gov (United States)

    Balit, Corrine R; Geary, Merilyn J; Russell, Richard C; Isbister, Geoffrey K

    2003-11-01

    Exposure to caterpillars results in a variety of clinical effects depending on the species involved. The aim of this study was to describe the clinical effects from caterpillar exposures within Australia. Cases were recruited prospectively from calls to a poison information centre. Subjects were included if they had a definite exposure and they had collected the caterpillar or cocoon. The caterpillars were identified to genus and species level where possible. There were 36 included cases: two were contact exposures to caterpillar contents, one was an ingestion of a caterpillar and the remaining 33 patients had definite reactions from caterpillar or cocoon exposure. There were five families of caterpillars identified in the study: Arctiidae, Limacodidae, Anthelidae, Lymantriidae and Sphingidae, many of which occur worldwide. Clinical effects ranged from severe pain to an urticarial response depending on the species involved. There were no adverse effects following ingestion in this study. Treatment consisted primarily of removal of the caterpillar or cocoon. Other treatment measures consisted of symptomatic treatment such as ice packs and antihistamines. This is the first prospective study of caterpillar exposures within Australia and demonstrates that exposures can result in a variety of reactions depending on the family and species involved. PMID:14602121

  11. Prospective Lymphedema Surveillance in a Clinic Setting.

    Science.gov (United States)

    Chance-Hetzler, Janet; Armer, Jane; Van Loo, Maggie; Anderson, Blake; Harris, Robin; Ewing, Rebecca; Stewart, Bob

    2015-01-01

    The potential impact of breast cancer-related lymphedema (LE) is quite extensive, yet it often remains under-diagnosed until the later stages. This project examines the effectiveness of prospective surveillance in post-surgical breast cancer patients. A retrospective analysis of 49 out of 100 patients enrolled in a longitudinal prospective study at a Midwestern breast center evaluates: (1) time required for completion of bilateral limb measurements and Lymphedema Breast Cancer Questionnaire (LBCQ); (2) referral to LE management with limb volume increase (LVI) and/or LBCQ symptoms; and (3) cost of LE management at lower LVI (≥5%-≤10%) versus traditional (≥10%). Findings revealed a visit timeframe mean of 40.3 min (range = 25-60); 43.6% of visits were ≤30-min timeframe. Visit and measurement times decreased as clinic staff gained measurement experience; measurement time mean was 17.9 min (range = 16.9-18.9). LBCQ symptoms and LVI were significantly (p < 0.001) correlated to LE referral; six of the nine patients referred (67%) displayed both LBCQ symptoms/LVI. Visits with no symptoms reported did not result in referral, demonstrating the importance of using both indicators when assessing early LE. Lower threshold referral provides compelling evidence of potential cost savings over traditional threshold referral with reported costs of: $3755.00 and $6353.00, respectively (40.9% savings). PMID:26308061

  12. Prospective Lymphedema Surveillance in a Clinic Setting

    Directory of Open Access Journals (Sweden)

    Janet Chance-Hetzler

    2015-08-01

    Full Text Available The potential impact of breast cancer-related lymphedema (LE is quite extensive, yet it often remains under-diagnosed until the later stages. This project examines the effectiveness of prospective surveillance in post-surgical breast cancer patients. A retrospective analysis of 49 out of 100 patients enrolled in a longitudinal prospective study at a Midwestern breast center evaluates: (1 time required for completion of bilateral limb measurements and Lymphedema Breast Cancer Questionnaire (LBCQ; (2 referral to LE management with limb volume increase (LVI and/or LBCQ symptoms; and (3 cost of LE management at lower LVI (≥5%–≤10% versus traditional (≥10%. Findings revealed a visit timeframe mean of 40.3 min (range = 25–60; 43.6% of visits were ≤30-min timeframe. Visit and measurement times decreased as clinic staff gained measurement experience; measurement time mean was 17.9 min (range = 16.9–18.9. LBCQ symptoms and LVI were significantly (p < 0.001 correlated to LE referral; six of the nine patients referred (67% displayed both LBCQ symptoms/LVI. Visits with no symptoms reported did not result in referral, demonstrating the importance of using both indicators when assessing early LE. Lower threshold referral provides compelling evidence of potential cost savings over traditional threshold referral with reported costs of: $3755.00 and $6353.00, respectively (40.9% savings.

  13. Convergent Validity of the PUTS

    Directory of Open Access Journals (Sweden)

    Valerie Cathérine Brandt

    2016-04-01

    Full Text Available Premonitory urges are a cardinal feature in Gilles de la Tourette syndrome. Severity of premonitory urges can be assessed with the Premonitory Urge for Tic Disorders Scale (PUTS. However, convergent validity of the measure has been difficult to assess due to the lack of other urge measures.We investigated the relationship between average real-time urge intensity assessed by an in-house developed real-time urge monitor, measuring urge intensity continuously for 5mins on a visual analogue scale, and general urge intensity assessed by the PUTS in 22 adult Tourette patients (mean age 29.8+/- 10.3; 19 male. Additionally, underlying factors of premonitory urges assessed by the PUTS were investigated in the adult sample using factor analysis and were replicated in 40 children and adolescents diagnosed with Tourette syndrome (mean age 12.05 +/- 2.83 SD, 31 male.Cronbach’s alpha for the PUTS10 was acceptable (α = .79 in the adult sample. Convergent validity between average real-time urge intensity scores (as assessed with the real-time urge monitor and the 10-item version of the PUTS (r = .64 and the 9-item version of the PUTS (r = .66 was good. A factor analysis including the 10 items of the PUTS and average real-time urge intensity scores revealed three factors. One factor included the average real-time urge intensity score and appeared to measure urge intensity, while the other two factors can be assumed to reflect the (sensory quality of urges and subjective control, respectively. The factor structure of the 10 PUTS items alone was replicated in a sample of children and adolescents.The results indicate that convergent validity between the PUTS and the real-time urge assessment monitor is good. Furthermore, the results suggest that the PUTS might assess more than one dimension of urges and it may be worthwhile developing different sub-scales of the PUTS assessing premonitory urges in terms of intensity and quality, as well as subjectively

  14. Validation of maritime spectral features

    Science.gov (United States)

    Hubler, Matthew J.

    In 1991 a research team led by Klaus Hasselmann developed a general technique to build synthetic aperture radar (SAR) spectra from scans of the ocean surface; however these techniques were verified on older equipment. The algorithms input a SAR spectrum from an ocean spectrum, an inversion from SAR spectrum to ocean spectrum, and determine the threshold of the azimuthal cutoff. Originally designed for platforms that have since fulfilled their missions, the question remains as to whether the algorithms are valid with newer systems such as TerraSAR-X operated by German Aerospace Centre (DLR). One of the larger differences that may skew data analysis by these algorithms is that TerraSAR-X has much finer resolution, pixels being on the scale of 5--10 meters (or less), while older satellites returned images with pixel scaling on the order of kilometers. The finer pixel scaling allows for more detail to be recovered and analyzed, specifically the individual waves on the ocean surface become visible. To that end, algorithms developed for older satellites will be employed on data collected from TerraSAR-X and compared to ground truth data in order to assess the compatibility of existing algorithms. During the course of the validation, several sets of code, written in Matlab, will be employed and discussed, each providing a different approach, more focused results. In aggregate a clearer picture will emerge describing the accuracy that older algorithms have with newer machinery. The imagery data, being satellite borne, comes with individual collection geometry that needs to be addressed in the processing as well, currently through parsing the accompanying metadata. The determination that these algorithms indeed work with newer systems and the validation of an azimuthal cutoff demonstrate that little fine tuning of older algorithms is needed at these higher resolutions. While the Hasselmann algorithms become cumbersome to use, a new approach to the algorithms yield useful

  15. Novel Cluster Validity Index for FCM Algorithm

    Institute of Scientific and Technical Information of China (English)

    Jian Yu; Cui-Xia Li

    2006-01-01

    How to determine an appropriate number of clusters is very important when implementing a specific clustering algorithm, like c-means, fuzzy c-means (FCM). In the literature, most cluster validity indices are originated from partition or geometrical property of the data set. In this paper, the authors developed a novel cluster validity index for FCM, based on the optimality test of FCM. Unlike the previous cluster validity indices, this novel cluster validity index is inherent in FCM itself. Comparison experiments show that the stability index can be used as cluster validity index for the fuzzy c-means.

  16. Validity of Parametrized Quark Propagator

    Institute of Scientific and Technical Information of China (English)

    ZHU Ji-Zhen; ZHOU Li-Juan; MA Wei-Xing

    2005-01-01

    Based on an extensively study of the Dyson-Schwinger equations for a fully dressed quark propagator in the "rainbow" approximation, a parametrized fully dressed quark propagator is proposed in this paper. The parametrized propagator describes a confining quark propagator in hadron since it is analytic everywhere in complex p2-plane and has no Lemmann representation. The validity of the new propagator is discussed by comparing its predictions on selfenergy functions Af(p2), Bf(p2) and effective mass Mf(p2) of quark with flavor f to their corresponding theoretical results produced by Dyson-Schwinger equations. Our comparison shows that the parametrized quark propagator is a good approximation to the fully dressed quark propagator given by the solutions of Dyson-Schwinger equations in the rainbow approximation and is convenient to use in any theoretical calculations.

  17. Validity of Parametrized Quark Propagator

    Institute of Scientific and Technical Information of China (English)

    ZHUJi-Zhen; ZHOULi-Juan; MAWei-Xing

    2005-01-01

    Based on an extensively study of the Dyson-Schwinger equations for a fully dressed quark propagator in the “rainbow”approximation, a parametrized fully dressed quark propagator is proposed in this paper. The parametrized propagator describes a confining quark propagator in hadron since it is analytic everywhere in complex p2-plane and has no Lemmann representation. The validity of the new propagator is discussed by comparing its predictions on selfenergy functions A/(p2), Bl(p2) and effective mass M$(p2) of quark with flavor f to their corresponding theoretical results produced by Dyson-Schwinger equations. Our comparison shows that the parametrized quark propagator is a good approximation to the fully dressed quark propagator given by the solutions of Dyson-Schwinger equations in the rainbow approximation and is convenient to use in any theoretical calculations.

  18. Multicopter Design Optimization and Validation

    Directory of Open Access Journals (Sweden)

    Øyvind Magnussen

    2015-04-01

    Full Text Available This paper presents a method for optimizing the design of a multicopter unmanned aerial vehicle (UAV, also called multirotor or drone. In practice a set of datasheets is available to the designer for the various components such as battery pack, motor and propellers. The designer can not normally design the parameters of the actuator system freely, but is constrained to pick components based on available datasheets. The mixed-integer programming approach is well suited to design optimization in such cases when only a discrete set of components is available. The paper also includes an experimental section where the simulated dynamic responses of optimized designs are compared against the experimental results. The paper demonstrates that mixed-integer programming is well suited to design optimization of multicopter UAVs and that the modeling assumptions match well with the experimental validation.

  19. PEMFC modeling and experimental validation

    Energy Technology Data Exchange (ETDEWEB)

    Vargas, J.V.C. [Federal University of Parana (UFPR), Curitiba, PR (Brazil). Dept. of Mechanical Engineering], E-mail: jvargas@demec.ufpr.br; Ordonez, J.C.; Martins, L.S. [Florida State University, Tallahassee, FL (United States). Center for Advanced Power Systems], Emails: ordonez@caps.fsu.edu, martins@caps.fsu.edu

    2009-07-01

    In this paper, a simplified and comprehensive PEMFC mathematical model introduced in previous studies is experimentally validated. Numerical results are obtained for an existing set of commercial unit PEM fuel cells. The model accounts for pressure drops in the gas channels, and for temperature gradients with respect to space in the flow direction, that are investigated by direct infrared imaging, showing that even at low current operation such gradients are present in fuel cell operation, and therefore should be considered by a PEMFC model, since large coolant flow rates are limited due to induced high pressure drops in the cooling channels. The computed polarization and power curves are directly compared to the experimentally measured ones with good qualitative and quantitative agreement. The combination of accuracy and low computational time allow for the future utilization of the model as a reliable tool for PEMFC simulation, control, design and optimization purposes. (author)

  20. Loads and loads and loads: The influence of prospective load, retrospective load, and ongoing task load in prospective memory

    Directory of Open Access Journals (Sweden)

    Beat eMeier

    2015-06-01

    Full Text Available In prospective memory tasks different kinds of load can occur. Adding a prospective memory task can impose a load on ongoing task performance. Adding ongoing task load can affect prospective memory performance. The existence of multiple target events increases prospective load and adding complexity to the to-be-remembered action increases retrospective load. In two experiments, we systematically examined the effects of these different types of load on prospective memory performance. Results showed an effect of prospective load on costs in the ongoing task for categorical targets (Experiment 2, but not for specific targets (Experiment 1. Retrospective load and ongoing task load both affected remembering the retrospective component of the prospective memory task. We suggest that prospective load can enhance costs in the ongoing task due to additional monitoring requirements. Retrospective load and ongoing task load seem to impact the division of resources between the ongoing task and retrieval of the retrospective component, which may affect disengagement from the ongoing task. In general, the results demonstrate that the different types of load affect prospective memory differentially.

  1. Scottish validation study of cancer registration data childhood leukaemia 1968-1981: Pt. 1

    International Nuclear Information System (INIS)

    This study attempted to validate central registration data on all childhood leukaemia cases in Scotland between 1968 and 1981 in line with the Black Enquiry concerning West Cumbria. Missing files precluded a complete verification, but minor errors of registration were found in 44% of cases. A small number of important mistakes of omission (eight cases), wrong diagnosis (six cases) and postal code errors (nine cases) were found which might affect epidemiological studies of these relatively rare diseases. Precise and verified prospective data collection at the time of diagnosis is essential if the spatial distribution of childhood cancers is being studied. (author)

  2. The gastro-esophageal reflux disease questionnaire using Indonesian language: A language validation survey

    OpenAIRE

    Marcellus Simadibrata; Aziz Rani; Pangestu Adi; Ali Djumhana; Murdani Abdullah

    2011-01-01

    Background: The aims of this study were to test the usefulness of the Gastro-esophageal Reflux Disease Questionnaire (GERDQ) in the diagnosis of GERD, to validate the GERDQ written in Indonesian language, and to evaluate the reliability of the GERDQ for use in Indonesian-speaking GERD patients (Virginia study).Methods: This was a prospective survey of 40 patients diagnosed with GERD, based on an endoscopic examination, in 3 cities in Indonesia (Jakarta, Bandung, and Surabaya) from 15 January ...

  3. [External validation of the short emergency geriatric assessment (SEGA) instrument on the SAFES cohort].

    Science.gov (United States)

    Tardieu, Émilie; Mahmoudi, Rachid; Novella, Jean-Luc; Oubaya, Nadia; Blanchard, François; Jolly, Damien; Dramé, Moustapha

    2016-03-01

    The aim of the study was to achieve the external validation of the SAGA instrument on the SAFES cohort. This was a prospective longitudinal multicentre cohort study, including patients aged 75 years or over, hospitalized in a short stay medical ward via emergency department. A comprehensive geriatric assessment was implemented. The psychometric validation enabled the study of feasibility, internal consistency, convergent, discriminant, and predictive validity of the instrument. The 1 306 patients of the cohort was 85±6 years, with a majority of women (65%). The completion rate of the SEGA instrument was 94%. Internal consistency was good (Cronbach alpha coefficient=0.7). Convergent validity was poor: Donini instrument (kappa=0.18; IC 95%=0.13-0.23), Rockwood instrument (kappa=0.04; IC 95%=0.02-0.06), and Winograd instrument (kappa=0.04; IC 95%=0.01-0.07). The ability of the instrument to discriminate clinically different groups was good. The SEGA instrument predicted well one-year mortality as well as one-year institution admission. Despite poor convergent validity (which is classic with frailty tools, SEGA instrument has satisfactory metrological properties, allowing its use in emergency departments and immediate post-emergency circumstances.

  4. THE DEVELOPMENT OF GUIDED INQUIRY SCIENCE LEARNING MATERIALS TO IMPROVE SCIENCE LITERACY SKILL OF PROSPECTIVE MI TEACHERS

    Directory of Open Access Journals (Sweden)

    M. I. S. Putra

    2016-04-01

    Full Text Available This study aimed to produce valid, practical and effective guided inquiry model science learning materials to enhance science literacy skill of prospective MI teachers. The tryout of the materials was implementedto students of MI teacher educationof Unipdu Jombang at academic year of 2015/2016 semesters 3 using One Group Pretest Posttest Design. The data collections were done using observation, testing, and questionnaires. Data were analysed using descriptive analysis of quantitative, qualitative and non-parametric statistical tests. The findings of the research were: 1 the learning materials were valid; 2 Practicality of the materials was tested through the implementation of lesson plans, while the learners’ activity wereappropriate to the guided inquirymodel; and 3 The effectiveness of the learning materials in terms of improvement of learning outcomes of students was seen from the n-gain with high category and increasing mastery of science literacy skills of learners also scored n-gain with high category and the response of students to the device and the implementation of learning is very positive. It was concluded that the materials were valid, practical, and effective to enhance science literacy skills of prospective MI teachers.

  5. Analyzing Perceptions of Prospective Teachers about Their Media Literacy Competencies

    Science.gov (United States)

    Recepoglu, Ergun; Ergun, Muammer

    2013-01-01

    The purpose of this study is to analyze perceptions of prospective teachers about their media literacy competencies in terms of different variables. This is a descriptive research in the survey model which tries to detect the current situation. Study group includes 580 prospective teachers from Turkish, Primary School, Social Studies, Science,…

  6. Neural Correlates of Prospective Memory across the Lifespan

    Science.gov (United States)

    Zollig, Jacqueline; West, Robert; Martin, Mike; Altgassen, Mareike; Lemke, Ulrike; Kliegel, Matthias

    2007-01-01

    Overview: Behavioural data reveal an inverted U-shaped function in the efficiency of prospective memory from childhood to young adulthood to later adulthood. However, prior research has not directly compared processes contributing to age-related variation in prospective memory across the lifespan, hence it is unclear whether the same factors…

  7. Skill Levels of Prospective Physics Teachers on Problem Posing

    Science.gov (United States)

    Cildir, Sema; Sezen, Nazan

    2011-01-01

    Problem posing is one of the topics which the educators thoroughly accentuate. Problem posing skill is defined as an introvert activity of a student's learning. In this study, skill levels of prospective physics teachers on problem posing were determined and their views on problem posing were evaluated. To this end, prospective teachers were given…

  8. Prospective Physics Teachers' Awareness of Radiation and Radioactivity

    Science.gov (United States)

    Tasoglu, Aslihan Kartal; Ates, Özlem; Bakaç, Mustafa

    2015-01-01

    The purpose of this study is to investigate prospective physics teachers' knowledge of and attitude towards radiation and radioactivity. Participants of this study are 56 prospective physics teachers. A questionnaire related with the knowledge about radiation and radiation fear was conducted. The results of this study showed that most of the…

  9. Investigating Prospective Teachers' Ability to Write Context-Based Problems

    Science.gov (United States)

    Ültay, Neslihan; Donmez Usta, Necla

    2016-01-01

    Purpose: The purpose of this study is to investigate the prospective teachers' ability to write context-based problems about the concepts in radioactivity unit. Methodology: The study is carried out in a university in Turkey with 21 prospective teachers in physics, chemistry and biology in 2014-2015 fall terms. In the study, data are collected…

  10. 36 CFR 5.14 - Prospecting, mining, and mineral leasing.

    Science.gov (United States)

    2010-07-01

    ... mineral leasing. 5.14 Section 5.14 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR COMMERCIAL AND PRIVATE OPERATIONS § 5.14 Prospecting, mining, and mineral leasing. Prospecting, mining, and the location of mining claims under the general mining laws and leasing under...

  11. 36 CFR 1005.14 - Prospecting, mining, and mineral leasing.

    Science.gov (United States)

    2010-07-01

    ... mineral leasing. 1005.14 Section 1005.14 Parks, Forests, and Public Property PRESIDIO TRUST COMMERCIAL AND PRIVATE OPERATIONS § 1005.14 Prospecting, mining, and mineral leasing. Prospecting, mining, and the location of mining claims under the general mining laws and leasing under the mineral leasing laws...

  12. An analysis of Timmermans’ critique of Prospect Theory

    NARCIS (Netherlands)

    Van de Kaa, E.J.

    2012-01-01

    In the European Journal of Transport and Infrastructure Research (EJTIR) Timmermans (2010) discussed the suitability of Prospect Theory for travel behaviour research. In that article appeared an assertion, about the explanatory performance of Prospect Theory with respect to choices in the TV game ‘D

  13. Motivating Inhibition--Reward Prospect Speeds up Response Cancellation

    Science.gov (United States)

    Boehler, Carsten N.; Hopf, Jens-Max; Stoppel, Christian M.; Krebs, Ruth M.

    2012-01-01

    Reward prospect has been demonstrated to facilitate various cognitive and behavioral operations, particularly by enhancing the speed and vigor of processes linked to approaching reward. Studies in this domain typically employed task regimes in which participants' overt responses are facilitated by prospective rewards. In contrast, we demonstrate…

  14. 42 CFR 456.705 - Prospective drug review.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Prospective drug review. 456.705 Section 456.705 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Claims Management System for Outpatient Drug Claims § 456.705 Prospective drug review. (a)...

  15. Prospective Secondary Mathematics Teachers' Perspectives and Mathematical Knowledge for Teaching

    Science.gov (United States)

    Karagöz-Akar, Gülseren

    2016-01-01

    This study investigated the relationship between prospective secondary mathematics teachers' perspectives and their mathematical knowledge for teaching in action. Data from two prospective teachers' practice-teachings, one in geometry and one in algebra, their lesson plans and self-reflections were analyzed with Teacher Perspectives and Knowledge…

  16. Prospective Chemistry Teachers' Conceptions of Chemical Thermodynamics and Kinetics

    Science.gov (United States)

    Sozbilir, Mustafa; Pinarbasi, Tacettin; Canpolat, Nurtac

    2010-01-01

    This study aimed at identifying specifically prospective chemistry teachers' difficulties in determining the differences between the concepts of chemical thermodynamics and kinetics. Data were collected from 67 prospective chemistry teachers at Kazim Karabekir Education Faculty of Ataturk University in Turkey during 2005-2006 academic year. Data…

  17. Validation of Magnetospheric Magnetohydrodynamic Models

    Science.gov (United States)

    Curtis, Brian

    Magnetospheric magnetohydrodynamic (MHD) models are commonly used for both prediction and modeling of Earth's magnetosphere. To date, very little validation has been performed to determine their limits, uncertainties, and differences. In this work, we performed a comprehensive analysis using several commonly used validation techniques in the atmospheric sciences to MHD-based models of Earth's magnetosphere for the first time. The validation techniques of parameter variability/sensitivity analysis and comparison to other models were used on the OpenGGCM, BATS-R-US, and SWMF magnetospheric MHD models to answer several questions about how these models compare. The questions include: (1) the difference between the model's predictions prior to and following to a reversal of Bz in the upstream interplanetary field (IMF) from positive to negative, (2) the influence of the preconditioning duration, and (3) the differences between models under extreme solar wind conditions. A differencing visualization tool was developed and used to address these three questions. We find: (1) For a reversal in IMF Bz from positive to negative, the OpenGGCM magnetopause is closest to Earth as it has the weakest magnetic pressure near-Earth. The differences in magnetopause positions between BATS-R-US and SWMF are explained by the influence of the ring current, which is included in SWMF. Densities are highest for SWMF and lowest for OpenGGCM. The OpenGGCM tail currents differ significantly from BATS-R-US and SWMF; (2) A longer preconditioning time allowed the magnetosphere to relax more, giving different positions for the magnetopause with all three models before the IMF Bz reversal. There were differences greater than 100% for all three models before the IMF Bz reversal. The differences in the current sheet region for the OpenGGCM were small after the IMF Bz reversal. The BATS-R-US and SWMF differences decreased after the IMF Bz reversal to near zero; (3) For extreme conditions in the solar

  18. The world nuclear market and its prospects

    International Nuclear Information System (INIS)

    This market study of the nuclear industry presents: 1 - the dynamics of nuclear markets: organisation of the nuclear industry (fuel cycle, reactors), market analysis and key figures (uranium production, conversion and enrichment, fuel fabrication, reactor manufacturing, spent fuel reprocessing), strengths in presence and competition structure (companies ranking, market shares, positioning); 2 - nuclear renaissance and its basis: a suitable answer to the present day energy and environmental challenges (carbon-free energy and low volatility of fuel price), conjunction of favourable conditions (security of fuel supplies, political support, necessity of plants renewal), three main uncertainties (waste management, safety aspect, public opinion weight); 3 - perspectives of development at the 2030 prospects: data (scope of renaissance, market size), sector reconfiguration scenarios (evolution of competition, reconfiguration paths, concentration trend); 4 - analysis of the strategy of 13 companies, suppliers of the nuclear industry, with their key figures, positioning and strategy (production capacity, partnerships, external growth investments, new technical developments etc.). (J.S.)

  19. Prospects for antiproton physics, my perspective

    Energy Technology Data Exchange (ETDEWEB)

    Oelert, Walter, E-mail: w.oelert@fz-juelich.de [Forschungszentrum Juelich (Germany)

    2012-12-15

    These closing remarks are not supposed to be a summary talk, for this please have a look to the individual contributions to be published in the proceedings, but rather some considerations on future prospects for antiproton physics. However, first I would like to appreciate the organizers idea for giving me the opportunity to thank them for a well balanced, exciting and interesting conference LEAP-2011 in this marvelous city of Vancouver. I am sure we all loved to be here and enjoyed the hospitality and the bond of friendship we could experience during these days. We appreciate the patience and help of all the local organizers where I especially would like to mention Jana Thomson for her endless and helpful assignment. Thank you all-the participants, the speakers, the conference chair, the sponsors-for making this conference a success and we are looking forward to the next occasion in this series of meetings which will be celebrated in Uppsala.

  20. PROSPECT - A precision oscillation and spectrum experiment

    CERN Document Server

    ,

    2015-01-01

    Segmented antineutrino detectors placed near a compact research reactor provide an excellent opportunity to probe short-baseline neutrino oscillations and precisely measure the reactor antineutrino spectrum. Close proximity to a reactor combined with minimal overburden yield a high background environment that must be managed through shielding and detector technology. PROSPECT is a new experimental effort to detect reactor antineutrinos from the High Flux Isotope Reactor (HFIR) at Oak Ridge National Laboratory, managed by UT Battelle for the U.S. Department of Energy. The detector will use novel lithium-loaded liquid scintillator capable of neutron/gamma pulse shape discrimination and neutron capture tagging. These enhancements improve the ability to identify neutrino inverse-beta decays and reject background events in analysis. Results from these efforts will be covered along with their implications for an oscillation search and a precision spectrum measurement.

  1. Predicting residents' performance: A prospective study

    Directory of Open Access Journals (Sweden)

    Ozuah Philip O

    2002-07-01

    Full Text Available Abstract Background Objective criteria for predicting residents' performance do not exist. The purpose of this study was to test the hypothesis that global assessment by an intern selection committee (ISC would correlate with the future performance of residents. Methods A prospective study of 277 residents between 1992 and 1999. Global assessment at the time of interview was compared to subsequent clinical (assessed by chief residents and cognitive performance (assessed by the American Board of Pediatrics in-service training examination. Results ISC ratings correlated significantly with clinical performance at 24 and 36 months of training (r = 0.58, P st, 2nd, and 3rd years of training (r = 0.35, P = .0016; r = 0.39, P = 0.0003; r = 0.50, P = 0.005 respectively. Conclusions Global assessment by an ISC predicted residents' clinical and cognitive performances.

  2. Prospects for Precision Neutrino Cross Section Measurements

    Energy Technology Data Exchange (ETDEWEB)

    Harris, Deborah A. [Fermilab

    2016-01-28

    The need for precision cross section measurements is more urgent now than ever before, given the central role neutrino oscillation measurements play in the field of particle physics. The definition of precision is something worth considering, however. In order to build the best model for an oscillation experiment, cross section measurements should span a broad range of energies, neutrino interaction channels, and target nuclei. Precision might better be defined not in the final uncertainty associated with any one measurement but rather with the breadth of measurements that are available to constrain models. Current experience shows that models are better constrained by 10 measurements across different processes and energies with 10% uncertainties than by one measurement of one process on one nucleus with a 1% uncertainty. This article describes the current status of and future prospects for the field of precision cross section measurements considering the metric of how many processes, energies, and nuclei have been studied.

  3. Prospective applications of optical quantum memories

    Science.gov (United States)

    Bussières, Félix; Sangouard, Nicolas; Afzelius, Mikael; de Riedmatten, Hugues; Simon, Christoph; Tittel, Wolfgang

    2013-10-01

    An optical quantum memory can be broadly defined as a system capable of storing a quantum state through interaction with light at optical frequencies. During the last decade, intense research was devoted to their development, mostly with the aim of fulfilling the requirements of their first two applications, namely quantum repeaters and linear-optical quantum computation. A better understanding of those requirements then motivated several different experimental approaches. Along the way, other exciting applications emerged, such as as quantum metrology, single-photon detection, tests of the foundations of quantum physics, device-independent quantum information processing and nonlinear processing of quantum information. Here we review several prospective applications of optical quantum memories, as well as recent experimental achievements pertaining to these applications. This review highlights that optical quantum memories have become essential for the development of optical quantum information processing.

  4. Dual-frequency IP over Tanghuping Prospect

    Institute of Scientific and Technical Information of China (English)

    Iraj Vosoughi-Niri; TANG Jing-tian

    2004-01-01

    Gold mineralization in the Tanghuping Prospect was the target of the geophysical exploration. The mineralization shows close relation with geological structures and is accompanied by alteration. Sulfide concentrations in the altered zones were used to trace the mineralization by Induced Polarization(IP) method. Through laboratory and field measurements of some selected samples of the study area, their geophysical properties were studied carefully.After that by numerical calculation, a geophysical model was built. Six lines were designed to use dual-frequency IP sounding in the west of the surveyed area. Gradient, pole-dipole and reverse pole-dipole arrays were used to acquire the data. Interpretation of the processed data shows eight veins that demonstrate diverging and converging phenomena. Therefore east of the surveyed area is considered as most prosperous zone in the study area.

  5. Business Tourism in Sochi: Issues and Prospects

    Directory of Open Access Journals (Sweden)

    Galina M. Romanova

    2014-03-01

    Full Text Available The article is devoted to the current problems and pe rspectives of business tourism in Sochi. The development of this segment of tourism may attract extra thousands of tourists. Development prospects of Sochi is associated with the forthcoming tourist boom and reincarnation of this local - popular resort into the international tourist destination. Business tourism is supposed to become an integral part of the local market development. The future of business tourism in Sochi will depend of different limits and factors such as t transport and communication infrast ructures, natural and u rban environments, openness to tourism, availability and cost of services etc. Sochi has a good potential to become a leader in business travel sector and after the Olympic Games it will substantially increase. The development of bus iness tourism on the local level will reduce seasonality

  6. PROSPECTIVE ROMANIAN LEADERS' VIEW ON LEADERSHIP DIMENSIONS

    Directory of Open Access Journals (Sweden)

    CATANA DOINA

    2010-07-01

    Full Text Available This study deals with Romanian prospective leaders' view on outstanding leadership dimensions (styles. It is a part of a European research project, GLOBE Students, dealing with the interrelations between societal culture and leadership. The basic theoretical constructs and methodological framework of investigation are those developed by GLOBE international research project. The sample consists in 429 students in business/economics and engineering, belonging to three Romanian universities. The findings show that the most preferred leadership styles are team oriented and charismatic (value based. Only a few leadership styles seem to have weak, but statistically significant correlations against a sig. = 0.50 probability threshold with important socialization agents for the students.

  7. Reproducibility principles, problems, practices, and prospects

    CERN Document Server

    Maasen, Sabine

    2016-01-01

    Featuring peer-reviewed contributions from noted experts in their fields of research, Reproducibility: Principles, Problems, Practices, and Prospects presents state-of-the-art approaches to reproducibility, the gold standard sound science, from multi- and interdisciplinary perspectives. Including comprehensive coverage for implementing and reflecting the norm of reproducibility in various pertinent fields of research, the book focuses on how the reproducibility of results is applied, how it may be limited, and how such limitations can be understood or even controlled in the natural sciences, computational sciences, life sciences, social sciences, and studies of science and technology. The book presents many chapters devoted to a variety of methods and techniques, as well as their epistemic and ontological underpinnings, which have been developed to safeguard reproducible research and curtail deficits and failures. The book also investigates the political, historical, and social practices that underlie repro...

  8. E-payments: Problems and Prospects

    Directory of Open Access Journals (Sweden)

    J. Raja

    2008-04-01

    Full Text Available The success of electronic commerce depends upon effective electronic payment systems. The Internet and on-line businesse s are growing exponentially.. Due to this explosive growth, electronic commerce on the Internet uses various electronic payment mechanisms that can cater for much diversity of applications. This paper discusses the evolution and the growth of electronic te chnologies, which can provide more advanced technical supports for electronic payment systems. The focus of this paper is to identify and explain the different methods of e-payment the authors analyses the challenges of electronic payments from different perspec tive and provide preliminary security countermeasures for each of the issues. Finally a number of solutions have been proposed based on the problem and discussed on the prospect of electronic payment system

  9. Prospects in MPGDs development for neutron detection

    CERN Document Server

    Guerard, Bruno; Murtas, Fabrizio

    2014-01-01

    Compared to Multi Wires Proportional Chambers (MWPC), Micro-Pattern Gas Detectors (MPGD) used in HEP to detect MIPs offer better spatial resolution, counting rate capability, and radiation hardness; their fabrication is also more reproducible. Provided similar advantages are applicable to detect neutrons, MPGDs might contribute significantly to the development of neutron scientific instrumentation. In order to evaluate the prospects of neutron MPGDs, it is worth knowing the applications which would benefit from a gain in performance, and if they offer a competitive alternative to conventional 3He detectors. These questions have been at the focus of the workshop "Neutron Detection with Micro-Pattern Gaseous Detectors" organized by RD51 in collaboration with HEPTech, which took place at CERN on October 14-15, 2013. The goal of this workshop was to help disseminating MPGD technologies beyond High Energy Physics, and to give the possibility to academic institutions, potential users and industry to meet together. ...

  10. Universal doomsday: analyzing our prospects for survival

    Energy Technology Data Exchange (ETDEWEB)

    Gerig, Austin [CABDyN Complexity Centre, Saïd Business School, University of Oxford, Oxford OX1 1HP (United Kingdom); Olum, Ken D.; Vilenkin, Alexander, E-mail: austin.gerig@sbs.ox.ac.uk, E-mail: kdo@cosmos.phy.tufts.edu, E-mail: vilenkin@cosmos.phy.tufts.edu [Institute of Cosmology, Department of Physics and Astronomy, Tufts University, Medford MA 02155 (United States)

    2013-05-01

    Given a sufficiently large universe, numerous civilizations almost surely exist. Some of these civilizations will be short-lived and die out relatively early in their development, i.e., before having the chance to spread to other planets. Others will be long-lived, potentially colonizing their galaxy and becoming enormous in size. What fraction of civilizations in the universe are long-lived? The ''universal doomsday'' argument states that long-lived civilizations must be rare because if they were not, we should find ourselves living in one. Furthermore, because long-lived civilizations are rare, our civilization's prospects for long-term survival are poor. Here, we develop the formalism required for universal doomsday calculations and show that while the argument has some force, our future is not as gloomy as the traditional doomsday argument would suggest, at least when the number of early existential threats is small.

  11. Universal doomsday: analyzing our prospects for survival

    International Nuclear Information System (INIS)

    Given a sufficiently large universe, numerous civilizations almost surely exist. Some of these civilizations will be short-lived and die out relatively early in their development, i.e., before having the chance to spread to other planets. Others will be long-lived, potentially colonizing their galaxy and becoming enormous in size. What fraction of civilizations in the universe are long-lived? The ''universal doomsday'' argument states that long-lived civilizations must be rare because if they were not, we should find ourselves living in one. Furthermore, because long-lived civilizations are rare, our civilization's prospects for long-term survival are poor. Here, we develop the formalism required for universal doomsday calculations and show that while the argument has some force, our future is not as gloomy as the traditional doomsday argument would suggest, at least when the number of early existential threats is small

  12. Banking Sector of Ukraine: Realities, Tendencies, Prospects

    Directory of Open Access Journals (Sweden)

    Doroshenko Hanna O.

    2014-01-01

    Full Text Available The article analyses the modern state of the banking sector of Ukraine, its sources and prospects. It identifies that the main obstacle for stable development is dissociation of banking segments, absence of functional unity and orientation at formation of optimal conditions for satisfaction of financial requirements of the domestic economy. In order to create the efficient banking system it is necessary to introduce new banking supervision standards oriented at specialisation of the banking activity. The banking market should be segmented and both major banks that form the nucleus of the segment and minor ones operating in their niches should co-operate within each segment. Universal banks that have a developed branch network should unite specialised segments. Moreover, it is necessary to introduce changes into the mechanism of application of some instruments of money and loan regulation with respect to specialised banks and introduce some restrictions upon spheres of activity of the foreign capital.

  13. Nuclear material management: challenges and prospects

    International Nuclear Information System (INIS)

    The articles in this dossier were derived from the papers of the yearly S.F.E.N. convention, which took place in Paris, 12-13 March 2008. They deal with the new challenges and prospects in the field of nuclear material management, throughout the nuclear whole fuel cycle, namely: the institutional frame of nuclear materials management, the recycling, the uranium market, the enrichment market, the different scenarios for the management of civil nuclear materials, the technical possibilities of spent fuels utilization, the option of thorium, the convention on the physical protection of nuclear materials and installations, the characterisation of nuclear materials by nondestructive nuclear measurements, the proliferation from civil installations, the use of plutonium ( from military origin) and the international agreements. (N.C.)

  14. Prospects for Breakthrough Propulsion From Physics

    Science.gov (United States)

    Millis, Marc G.

    2004-01-01

    "Space drives", "Warp drives", and "Wormholes:" these concepts may sound like science fiction, but they are being written about in reputable journals. To assess the implications of these emerging prospects for future spaceflight, NASA supported the Breakthrough Propulsion Physics Project from 1996 through 2002. This Project has three grand challenges: (1) Discover propulsion that eliminates the need for propellant; (2) Discover methods to achieve hyper-fast travel; and (3) Discover breakthrough methods to power spacecraft. Because these challenges are presumably far from fruition, and perhaps even impossible, a special emphasis is placed on selecting incremental and affordable research that addresses the critical issues behind these challenges. Of 16 incremental research tasks completed by the project and from other sponsors, about a third were found not to be viable, a quarter have clear opportunities for sequels, and the rest remain unresolved.

  15. Moon Prospective Energy and Material Resources

    CERN Document Server

    2012-01-01

    The Earth has limited material and energy resources. Further development of the humanity will require going beyond our planet for mining and use of extraterrestrial mineral resources and search of power sources. The exploitation of the natural resources of the Moon is a first natural step on this direction. Lunar materials may contribute to the betterment of conditions of people on Earth but they also may be used to establish permanent settlements on the Moon. This will allow developing new technologies, systems and flight operation techniques to continue space exploration.   In fact, a new branch of human civilization could be established permanently on Moon in the next century. But, meantime, an inventory and proper social assessment of Moon’s prospective energy and material resources is required. This book investigates the possibilities and limitations of various systems supplying manned bases on Moon with energy and other vital resources. The book collects together recent proposals and innovative optio...

  16. The prospects for dry fuel storage

    International Nuclear Information System (INIS)

    Dry storage of spent nuclear fuels is one method of dealing with radioactive waste. This article reports from a one day seminar on future prospects for dry fuel storage held in November 1993. Dry storage in an inert gas or air environment in vaults or casks, is an alternative to wet storage in water-filled ponds. Both wet and dry storage form part of the Interim Storage option for radioactive waste materials, and form alternatives to reprocessing or direct disposal in a deep repository. It has become clear that a large market for dry fuel storage will exist in the future. It will therefore be necessary to ensure that the various technical, safety, commercial, legislative and political constraints associated with it can be met effectively. (UK)

  17. Innovation and design approaches within prospective ergonomics.

    Science.gov (United States)

    Liem, André; Brangier, Eric

    2012-01-01

    In this conceptual article the topic of "Prospective Ergonomics" will be discussed within the context of innovation, design thinking and design processes & methods. Design thinking is essentially a human-centred innovation process that emphasises observation, collaboration, interpretation, visualisation of ideas, rapid concept prototyping and concurrent business analysis, which ultimately influences innovation and business strategy. The objective of this project is to develop a roadmap for innovation, involving consumers, designers and business people in an integrative process, which can be applied to product, service and business design. A theoretical structure comprising of Innovation perspectives (1), Worldviews supported by rationalist-historicist and empirical-idealistic dimensions (2) and Models of "design" reasoning (3) precedes the development and classification of existing methods as well as the introduction of new ones.

  18. A prospect. Plasma physics, quo vadis

    International Nuclear Information System (INIS)

    A prospect of plasma physics at the turn of new century is discussed. The theme of this conference identifies the future direction of the research related with plasmas. Main issue is the potential and structure formation in plasmas; More specifically, structures which are realized through the interaction of electromagnetic fields, in particular that with electric fields, in non-equilibrium state. An emphasis is made to clarify the fundamental physics aspects of the plasma physics in fusion research as well as that in the basic research of plasmas. The plasma physics will give important contribution to the solution of the historical enigma, i.e., all thing flow. Having an impact on human recognition of nature and showing a beauty in a law, the plasma physics/science will demonstrate to be a high-quality science in the 21st century. (author)

  19. Asteroids prospective energy and material resources

    CERN Document Server

    2013-01-01

    The Earth has limited material and energy resources while these resources in space are virtually unlimited. Further development of humanity will require going beyond our planet and exploring of extraterrestrial resources and sources of unlimited power.   Thus far, all missions to asteroids have been motivated by scientific exploration. However, given recent advancements in various space technologies, mining asteroids for resources is becoming ever more feasible. A significant portion of asteroids value is derived from their location; the required resources do not need to be lifted at a great expense from the surface of the Earth.   Resources derived from Asteroid not only can be brought back to Earth but could also be used to sustain human exploration of space and permanent settlements in space.   This book investigates asteroids' prospective energy and material resources. It is a collection of topics related to asteroid exploration, and utilization. It presents past and future technologies and solutions t...

  20. HIGH ENERGY POLARIZATION OF BLAZARS: DETECTION PROSPECTS

    Energy Technology Data Exchange (ETDEWEB)

    Chakraborty, N. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, D-69117 Heidelberg (Germany); Pavlidou, V. [Department of Physics, University of Crete, 71003 Heraklion (Greece); Fields, B. D. [Department of Astronomy and Department of Physics, University of Illinois, Urbana, IL 61801 (United States)

    2015-01-01

    Emission from blazar jets in the ultraviolet, optical, and infrared is polarized. If these low-energy photons were inverse-Compton scattered, the upscattered high-energy photons retain a fraction of the polarization. Current and future X-ray and gamma-ray polarimeters such as INTEGRAL-SPI, PoGOLITE, X-Calibur, Gamma-Ray Burst Polarimeter, GEMS-like missions, ASTRO-H, and POLARIX have the potential to discover polarized X-rays and gamma-rays from blazar jets for the first time. Detection of such polarization will open a qualitatively new window into high-energy blazar emission; actual measurements of polarization degree and angle will quantitatively test theories of jet emission mechanisms. We examine the detection prospects of blazars by these polarimetry missions using examples of 3C 279, PKS 1510-089, and 3C 454.3, bright sources with relatively high degrees of low-energy polarization. We conclude that while balloon polarimeters will be challenged to detect blazars within reasonable observational times (with X-Calibur offering the most promising prospects), space-based missions should detect the brightest blazars for polarization fractions down to a few percent. Typical flaring activity of blazars could boost the overall number of polarimetric detections by nearly a factor of five to six purely accounting for flux increase of the brightest of the comprehensive, all-sky, Fermi-LAT blazar distribution. The instantaneous increase in the number of detections is approximately a factor of two, assuming a duty cycle of 20% for every source. The detectability of particular blazars may be reduced if variations in the flux and polarization fraction are anticorrelated. Simultaneous use of variability and polarization trends could guide the selection of blazars for high-energy polarimetric observations.

  1. Prospective analysis. Nuclear deterrence in 2030; Essai de prospective. La dissuasion nucleaire en 2030

    Energy Technology Data Exchange (ETDEWEB)

    Tertrais, B

    2006-12-15

    This study is a prospective analysis of the long-term future of nuclear weapons, and particularly the future of French nuclear deterrence after 2015. The selected time period is 2025-2030. The principal objective is to reflect on what the nuclear world might look like during the first part of the 21 st century, beyond the modernization decisions already planned or envisaged, and to draw conclusions for the future of the French deterrent. (author)

  2. The technological prospective of non nuclear channels; La prospective technologique des filieres non nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Claverie, M.; Clement, D.; Girard, C

    2000-07-15

    This prospective study concerns the electric power demand in 2050. It examines the three non nuclear sectors of production: the natural gas combined cycle power plants, the wind turbines among the renewable energies and the cogeneration electric power - heat in the ternary and building sector. The necessity of the network adaptation to the european competition and the decentralized production of electric power will suppose new investments of transport and storage. (A.L.B.)

  3. How valid are commercially available medical simulators?

    Directory of Open Access Journals (Sweden)

    Stunt JJ

    2014-10-01

    Full Text Available JJ Stunt,1 PH Wulms,2 GM Kerkhoffs,1 J Dankelman,2 CN van Dijk,1 GJM Tuijthof1,2 1Orthopedic Research Center Amsterdam, Department of Orthopedic Surgery, Academic Medical Centre, Amsterdam, the Netherlands; 2Department of Biomechanical Engineering, Faculty of Mechanical, Materials and Maritime Engineering, Delft University of Technology, Delft, the Netherlands Background: Since simulators offer important advantages, they are increasingly used in medical education and medical skills training that require physical actions. A wide variety of simulators have become commercially available. It is of high importance that evidence is provided that training on these simulators can actually improve clinical performance on live patients. Therefore, the aim of this review is to determine the availability of different types of simulators and the evidence of their validation, to offer insight regarding which simulators are suitable to use in the clinical setting as a training modality. Summary: Four hundred and thirty-three commercially available simulators were found, from which 405 (94% were physical models. One hundred and thirty validation studies evaluated 35 (8% commercially available medical simulators for levels of validity ranging from face to predictive validity. Solely simulators that are used for surgical skills training were validated for the highest validity level (predictive validity. Twenty-four (37% simulators that give objective feedback had been validated. Studies that tested more powerful levels of validity (concurrent and predictive validity were methodologically stronger than studies that tested more elementary levels of validity (face, content, and construct validity. Conclusion: Ninety-three point five percent of the commercially available simulators are not known to be tested for validity. Although the importance of (a high level of validation depends on the difficulty level of skills training and possible consequences when skills are

  4. Mechanisms underlying the link between cannabis use and prospective memory.

    Directory of Open Access Journals (Sweden)

    Carrie Cuttler

    Full Text Available While the effects of cannabis use on retrospective memory have been extensively examined, only a limited number of studies have focused on the links between cannabis use and prospective memory. We conducted two studies to examine the links between cannabis use and both time-based and event-based prospective memory as well as potential mechanisms underlying these links. For the first study, 805 students completed an online survey designed to assess cannabis consumption, problems with cannabis use indicative of a disorder, and frequency of experiencing prospective memory failures. The results showed small to moderate sized correlations between cannabis consumption, problems with cannabis use, and prospective memory. However, a series of mediation analyses revealed that correlations between problems with cannabis use and prospective memory were driven by self-reported problems with retrospective memory. For the second study, 48 non-users (who had never used cannabis, 48 experimenters (who had used cannabis five or fewer times in their lives, and 48 chronic users (who had used cannabis at least three times a week for one year were administered three objective prospective memory tests and three self-report measures of prospective memory. The results revealed no objective deficits in prospective memory associated with chronic cannabis use. In contrast, chronic cannabis users reported experiencing more internally-cued prospective memory failures. Subsequent analyses revealed that this effect was driven by self-reported problems with retrospective memory as well as by use of alcohol and other drugs. Although our samples were not fully characterized with respect to variables such as neurological disorders and family history of substance use disorders, leaving open the possibility that these variables may play a role in the detected relationships, the present findings indicate that cannabis use has a modest effect on self-reported problems with

  5. Isothermal air ingress validation experiments

    International Nuclear Information System (INIS)

    Idaho National Laboratory carried out air ingress experiments as part of validating computational fluid dynamics (CFD) calculations. An isothermal test loop was designed and set to understand the stratified-flow phenomenon, which is important as the initial air flow into the lower plenum of the very high temperature gas cooled reactor (VHTR) when a large break loss-of-coolant accident occurs. The unique flow characteristics were focused on the VHTR air-ingress accident, in particular, the flow visualization of the stratified flow in the inlet pipe to the vessel lower plenum of the General Atomic's Gas Turbine-Modular Helium Reactor (GT-MHR). Brine and sucrose were used as heavy fluids, and water was used to represent a light fluid, which mimics a counter current flow due to the density difference between the stimulant fluids. The density ratios were changed between 0.87 and 0.98. This experiment clearly showed that a stratified flow between simulant fluids was established even for very small density differences. The CFD calculations were compared with experimental data. A grid sensitivity study on CFD models was also performed using the Richardson extrapolation and the grid convergence index method for the numerical accuracy of CFD calculations . As a result, the calculated current speed showed very good agreement with the experimental data, indicating that the current CFD methods are suitable for predicting density gradient stratified flow phenomena in the air-ingress accident. (author)

  6. Seismic Data Gathering and Validation

    Energy Technology Data Exchange (ETDEWEB)

    Coleman, Justin [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-02-01

    Three recent earthquakes in the last seven years have exceeded their design basis earthquake values (so it is implied that damage to SSC’s should have occurred). These seismic events were recorded at North Anna (August 2011, detailed information provided in [Virginia Electric and Power Company Memo]), Fukushima Daichii and Daini (March 2011 [TEPCO 1]), and Kaswazaki-Kariwa (2007, [TEPCO 2]). However, seismic walk downs at some of these plants indicate that very little damage occurred to safety class systems and components due to the seismic motion. This report presents seismic data gathered for two of the three events mentioned above and recommends a path for using that data for two purposes. One purpose is to determine what margins exist in current industry standard seismic soil-structure interaction (SSI) tools. The second purpose is the use the data to validated seismic site response tools and SSI tools. The gathered data represents free field soil and in-structure acceleration time histories data. Gathered data also includes elastic and dynamic soil properties and structural drawings. Gathering data and comparing with existing models has potential to identify areas of uncertainty that should be removed from current seismic analysis and SPRA approaches. Removing uncertainty (to the extent possible) from SPRA’s will allow NPP owners to make decisions on where to reduce risk. Once a realistic understanding of seismic response is established for a nuclear power plant (NPP) then decisions on needed protective measures, such as SI, can be made.

  7. Validation for a recirculation model.

    Science.gov (United States)

    LaPuma, P T

    2001-04-01

    Recent Clean Air Act regulations designed to reduce volatile organic compound (VOC) emissions have placed new restrictions on painting operations. Treating large volumes of air which contain dilute quantities of VOCs can be expensive. Recirculating some fraction of the air allows an operator to comply with environmental regulations at reduced cost. However, there is a potential impact on employee safety because indoor pollutants will inevitably increase when air is recirculated. A computer model was developed, written in Microsoft Excel 97, to predict compliance costs and indoor air concentration changes with respect to changes in the level of recirculation for a given facility. The model predicts indoor air concentrations based on product usage and mass balance equations. This article validates the recirculation model using data collected from a C-130 aircraft painting facility at Hill Air Force Base, Utah. Air sampling data and air control cost quotes from vendors were collected for the Hill AFB painting facility and compared to the model's predictions. The model's predictions for strontium chromate and isocyanate air concentrations were generally between the maximum and minimum air sampling points with a tendency to predict near the maximum sampling points. The model's capital cost predictions for a thermal VOC control device ranged from a 14 percent underestimate to a 50 percent overestimate of the average cost quotes. A sensitivity analysis of the variables is also included. The model is demonstrated to be a good evaluation tool in understanding the impact of recirculation.

  8. SACCHAROMYCES CEREVISIAE AND ITS VALIDATION

    Directory of Open Access Journals (Sweden)

    Miroslav Ondrejovič

    2015-02-01

    Full Text Available The aim of this study was to optimize of independent variables as temperature, time and reaction ratio to output parameter of simultaneous enzyme saccharification and fermentation by Saccharomyces cerevisiae of pretreated wheat straw as model substrate via RSM (response surface methodology approach. As dependent variable, it was chosen ethanol yields characterizing effectivity of process. The optimal conditions were approximately temperature 100 °C, time 1 hour and reaction ratio 26 mL to 1 g of treated wheat straw with ethanol yields 141.9 mg.g-1. After calculating the optimal values, the validation analyze was carried out and it was found out that the predicted and experimentally verified dependent variable was in agreement with the optimal parameters (~ 95 %. Proposed model was tested for three lignocellulosic materials (winter wheat straw, alfalfa hay and maize straw as wheat straw used as model substrate and it was confirmed the possibility of its use for other agricultural residues with similar content of lignocellulose.

  9. ISOTHERMAL AIR INGRESS VALIDATION EXPERIMENTS

    Energy Technology Data Exchange (ETDEWEB)

    Chang H Oh; Eung S Kim

    2011-09-01

    Idaho National Laboratory carried out air ingress experiments as part of validating computational fluid dynamics (CFD) calculations. An isothermal test loop was designed and set to understand the stratified-flow phenomenon, which is important as the initial air flow into the lower plenum of the very high temperature gas cooled reactor (VHTR) when a large break loss-of-coolant accident occurs. The unique flow characteristics were focused on the VHTR air-ingress accident, in particular, the flow visualization of the stratified flow in the inlet pipe to the vessel lower plenum of the General Atomic’s Gas Turbine-Modular Helium Reactor (GT-MHR). Brine and sucrose were used as heavy fluids, and water was used to represent a light fluid, which mimics a counter current flow due to the density difference between the stimulant fluids. The density ratios were changed between 0.87 and 0.98. This experiment clearly showed that a stratified flow between simulant fluids was established even for very small density differences. The CFD calculations were compared with experimental data. A grid sensitivity study on CFD models was also performed using the Richardson extrapolation and the grid convergence index method for the numerical accuracy of CFD calculations . As a result, the calculated current speed showed very good agreement with the experimental data, indicating that the current CFD methods are suitable for predicting density gradient stratified flow phenomena in the air-ingress accident.

  10. Software Validation via Model Animation

    Science.gov (United States)

    Dutle, Aaron M.; Munoz, Cesar A.; Narkawicz, Anthony J.; Butler, Ricky W.

    2015-01-01

    This paper explores a new approach to validating software implementations that have been produced from formally-verified algorithms. Although visual inspection gives some confidence that the implementations faithfully reflect the formal models, it does not provide complete assurance that the software is correct. The proposed approach, which is based on animation of formal specifications, compares the outputs computed by the software implementations on a given suite of input values to the outputs computed by the formal models on the same inputs, and determines if they are equal up to a given tolerance. The approach is illustrated on a prototype air traffic management system that computes simple kinematic trajectories for aircraft. Proofs for the mathematical models of the system's algorithms are carried out in the Prototype Verification System (PVS). The animation tool PVSio is used to evaluate the formal models on a set of randomly generated test cases. Output values computed by PVSio are compared against output values computed by the actual software. This comparison improves the assurance that the translation from formal models to code is faithful and that, for example, floating point errors do not greatly affect correctness and safety properties.

  11. Estimation of 10-year risk of coronary heart disease in nepalese patients with type 2 diabetes: Framingham versus United Kingdom prospective diabetes study

    OpenAIRE

    Daya Ram Pokharel; Dipendra Khadka; Manoj Sigdel; Naval Kishor Yadav; Lokendra Bahadur Sapkota; Ramchandra Kafle; Sarthak Nepal; Ravindra Mohan Sapkota; Niraj Choudhary

    2015-01-01

    Background: Predicting future coronary heart disease (CHD) risk with the help of a validated risk prediction function helps clinicians identify diabetic patients at high risk and provide them with appropriate preventive medicine. Aim: The aim of this study is to estimate and compare 10-year CHD risks of Nepalese diabetic patients using two most common risk prediction functions: The Framingham risk equation and United Kingdom Prospective Diabetes Study (UKPDS) risk engine that are yet to be va...

  12. Triglycerides as a biological marker of repeated re-hospitalization resulting from deliberate self-harm in acute psychiatry patients: a prospective observational study

    OpenAIRE

    Roaldset, John Olav; Linaker, Olav Morten; Bjørkly, Stål

    2014-01-01

    Background: Biological factors have been associated with deliberate self-harm (DSH) but have not been integrated with clinical factors in routine risk assessments. This study aimed to examine the incremental validity of lipid levels and platelet serotonin when combined with psychosocial factors in risk assessments for repeated admissions due to DSH. Methods: In this prospective observational study of 196 acutely admitted patients, results of blood tests performed upon admission and the MI...

  13. Can self-reported BMI be used as a valid measure among novice runners

    DEFF Research Database (Denmark)

    Juul, Martin Serup; Nielsen, R.O.; Rasmussen, Sten

    There is an increased risk of running related injuries (RRI) among novice runners with a Body Mass Index (BMI) above 25. Information about BMI can be collected through questionnaires, when studies investigate if there is an association between BMI and RRI among novice runners. But can self-reported...... BMI be used as a valid measure compared to BMI measured with a calibrated weight. PURPOSE : To determine the validity of self-reported BMI among novice runners. METHODS: Data on BMI was obtained from a prospective follow-up study investigating the link between training exposure and the development...... SC-330) while their height was measured with a tape measure. Based on these data BMI were calculated based on the equation: BMI = mass (kg) / (height (m))2. Paired t-test was used to compare mean difference between self-reported BMI and measured BMI. Bland Altman limits of agreement were used...

  14. The contribution of retrospective memory, attention and executive functions to the prospective and retrospective components of prospective memory following TBI.

    LENUS (Irish Health Repository)

    Clune-Ryberg, Melanie

    2011-01-01

    Despite the prevalence of prospective memory (PM) problems, relatively little is known about the processes underlying impairment following TBI. This study sought to examine PM performance, using a multiple-task, multiple-response video-based paradigm in which initial encoding of the cue-action associations was ensured (Video-Assessment of Prospective Memory; VAPM).

  15. Comparative Validation of Building Simulation Software

    DEFF Research Database (Denmark)

    Kalyanova, Olena; Heiselberg, Per

    _2 and DSF200_4, the third empirical test case is also specified as DSF400_3, but it's completion is under consideration. The comparative test cases can not be directly used for the validation of the software due to often disagreement of the results, however the result of the exercises...... is that the comparative validation can be regarded as the main argument to continue the validation of the building simulation software for the buildings with the double skin façade with the empirical validation test cases.......The scope of this subtask is to perform a comparative validation of the building simulation software for the buildings with the double skin façade. The outline of the results in the comparative validation identifies the areas where is no correspondence achieved, i.e. calculation of the air flow...

  16. High speed data bus design validation

    Science.gov (United States)

    Stevens, Rick

    The SAE Linear Implementation Task Group has developed the SAE Linear Token Passing Multiplex Data Bus Standard (AS4074.1) and is currently working on a validation plan. This validation plan will define the test requirements for determining that an implementation of the standard meets the requirements of SAE AS4074.1. Once completed, the test requirements contained in this plan will be executed on bus interface units (BIUs) for validation purposes. In the present work, the author describes the use of a validation model that incorporates many of the capabilities of the validation test plan. This model can also be thought of as a VHDL (VHSIC Hardware Description Language) behavioral representation of the SAE Linear Token Passing Multiplex Data Bus Standard. It is tightly coupled to the standard and provides a model that can be used during the BIU development to validate the design.

  17. Validation studies in nursing: integrative review

    Directory of Open Access Journals (Sweden)

    Maria Andréia silva Ribeiro

    2013-05-01

    Full Text Available The aim of this study was to analyze the methods used for validation studies in nursing research considering the clinical investigation as phenomenon. We carried out literature at BIREME, CINAHL, PUBMED which contain the terms 'validation studies', 'nursing' and 'clinical' and 21 articles were included in the review. The majority of the studies were conducted in 2008; in North America (USA and European Community (62% in the area of adult health. Most of the phenomena investigated were related to nursing care involving physical and emotional aspects. The content validity has been cited in 71.4% of the articles, criterion validity in 28.5% and construct validity in 23.8%. The reliability by means of Cronbach's alpha was used in the majority of the studies. It was found a knowledge gap concerning the validation estudies in the area of public health, child health and the social phenomena related to nursing care.

  18. Validation of the mindful coping scale

    OpenAIRE

    Kjersti B. Tharaldsen; Bru, Edvin

    2011-01-01

    The aim of this research is to develop and validate a self-report measure of mindfulness and coping, the mindful coping scale (MCS). Dimensions of mindful coping were theoretically deduced from mindfulness theory and coping theory. The MCS was empirically evaluated by use of factor analyses, reliability testing and nomological network validation. The study’s participants were high school students from two high schools, covering all streams. Further validation was obtained by co...

  19. [Computerized system validation of clinical researches].

    Science.gov (United States)

    Yan, Charles; Chen, Feng; Xia, Jia-lai; Zheng, Qing-shan; Liu, Daniel

    2015-11-01

    Validation is a documented process that provides a high degree of assurance. The computer system does exactly and consistently what it is designed to do in a controlled manner throughout the life. The validation process begins with the system proposal/requirements definition, and continues application and maintenance until system retirement and retention of the e-records based on regulatory rules. The objective to do so is to clearly specify that each application of information technology fulfills its purpose. The computer system validation (CSV) is essential in clinical studies according to the GCP standard, meeting product's pre-determined attributes of the specifications, quality, safety and traceability. This paper describes how to perform the validation process and determine relevant stakeholders within an organization in the light of validation SOPs. Although a specific accountability in the implementation of the validation process might be outsourced, the ultimate responsibility of the CSV remains on the shoulder of the business process owner-sponsor. In order to show that the compliance of the system validation has been properly attained, it is essential to set up comprehensive validation procedures and maintain adequate documentations as well as training records. Quality of the system validation should be controlled using both QC and QA means. PMID:26911028

  20. The Particle Cleanliness Validation System

    Energy Technology Data Exchange (ETDEWEB)

    Stowers, I.F.; Ravizza, D.L.

    2001-12-21

    The Particle Cleanliness Validation System (PCVS) is a combination of a surface particle collection tool and a microscope based data, reduction system for determining the particle cleanliness of mechanical and optical surfaces at LLNL. Livermore is currently constructing the National Ignition Facility (NIF), a large 192 beam laser system for studying fusion physics. The laser is entirely enclosed. in aluminum and stainless steel vessels containing several environments; air, argon, and vacuum. It contains uncoated optics as well as hard dielectric coated and softer solgel coated optics which are, to varying degrees, sensitive to opaque particles, translucent particles, and molecular contamination. To quantify the particulate matter on structural surfaces during vendor cleaning and installation, a novel instrument has been developed to-both collect surface particles and to quantify the number and size distribution of these particles. The particles are collected on membrane filter paper which is ''swiped'' on a test surface for a proscribed distance to collect sufficient particles to significantly exceed the cleanliness of the filter paper. The swipe paper is then placed into a cassette for protection from further. contamination and transported to a microscope with x-y motorized stage and image analysis software, The surface of the swipe paper is scanned to determine both the background particle level of the paper, the cassette cover, and the portion of the paper which made contact with the test surface. The cumulative size distribution of the collected particles are displayed in size bins from 5 to 200 {micro}m. The quantity of particles exceeding 5 {micro}m is used to compute the IEST-STD-1246D cleanliness Level. Eight image analysis microscopes have been constructed for use with several dozen particle collection tools. About 30,000 cleanliness measurements have been taken to assure the clean construction and operation of the NIF laser system.

  1. Grade Validity of Online Quantitative Courses

    Science.gov (United States)

    Faurer, Judson C.

    2013-01-01

    Are prospective employers getting "quality" educated, degreed applicants and are academic institutions that offer online degree programs ensuring the quality control of the courses/programs offered? The issue specifically addressed in this paper is not with all institutions offering degrees through online programs or even with all online…

  2. EPR Dosimetry: an update and prospective studies

    International Nuclear Information System (INIS)

    Electron Paramagnetic Resonance (EPR) technique is useful to quantify the paramagnetic species in any matrix. The unpaired electrons present in paramagnetic materials have non - zero spin value, have an associated spin magnetic moment. When such a system is subjected to an external magnetic field, electronic Zeeman splitting of ground level state occurs. On application of suitable stimulant microwave energy, the electrons flip between the Zeeman levels of ground state, result in resonant absorption of the microwave energy. The intensity of resonant absorption signal is proportional to the concentration of the unpaired electrons in the irradiated material, could lead to possible use of such materials in EPR dosimetric applications. New materials were investigated for EPR dosimetry, wherein the radiation induced paramagnetic species retains the radiation signatures, lead to idea on radiation dose. Few of the materials have been identified as prospective EPR dosimeters. The radiation induced radical in Li2CO3 powder material being paramagnetic in nature (signals at g = 2.0036 and at g 2.0006) and radical concentration varying as a function of irradiation dose, led to its identification for possible use in EPR dosimetric applications. Besides, during the neutron irradiations, the reaction 6Li (n,α) 3H, led to the yield of radicals many folds higher compared to that of gamma irradiation. Thus, the commonly available Li2CO3 material has been assessed for the EPR dosimetric response in gamma and neutron environments. EPR investigation of Li2C2O4, Na2C2O4 mixtures was carried out to measure the radiation dose from γ photons and thermal neutrons in a mixed radiation field. A single line spectrum of CO2- radical at g = 2.0045 ± 0.0005 was found on gamma and neutron irradiations. Of all the mixture combinations, the 2:1 mixture was found more sensitive for gamma / thermal neutrons. Intensity of CO2- radical signal was found linear from 6 Gy - 11 kGy for gamma and 40 - 1500

  3. Orthodeoxia and postural orthostatic tachycardia in patients with pulmonary arteriovenous malformations: a prospective 8-year series.

    Science.gov (United States)

    Santhirapala, V; Chamali, B; McKernan, H; Tighe, H C; Williams, L C; Springett, J T; Bellenberg, H R; Whitaker, A J; Shovlin, C L

    2014-11-01

    Postural changes in 258 patients with pulmonary arteriovenous malformations (PAVMs) reviewed between 2005 and 2013 were evaluated prospectively using validated pulse oximetry methods. Of the 257 completing the test, 75 (29%) demonstrated orthodeoxia with an oxygen saturation fall of at least 2% on standing. None described platypnoea (dyspnoea on standing). The heart rate was consistently higher in the erect posture: 74 (29%) had a postural orthostatic tachycardia of ≥20 min(-1), and in 25 (10%) this exceeded 30 min(-1). Orthostatic tachycardia was more pronounced in PAVM patients than controls without orthodeoxia (age-adjusted coefficient 5.5 (95% CIs 2.6, 8.4) min(-1), ppostural orthostatic tachycardia syndrome, in this population, there was a trend for more pronounced orthostatic tachycardia to be associated with better exercise tolerance.

  4. Geophysical prospecting of the landfill near Mydlovary-Zahaji in Southern Bohemia

    International Nuclear Information System (INIS)

    Geoelectric methods of measurement are well suited for inorganic contaminants (salt, acid, lye) that affect the groundwater resistance. There are many publications on the interdependence between rock resistance and groundwater resistance. The so-called formation factor, i.e. the ratio between these two parameters, was defined by Archie already in 1942. Further research was done on the influence of clay and coarse clay on the formation factor. It was found that (especially at higher electrolyte concentrations) the dependence of rock resistance on groundwater resistance is always valid and is used in practice for assessing the groundwater resistance in petroleum prospecting. This is the theoretical basis for the use of geoelectric resistance method in the detection and mapping of soil pollution. Abandoned mining areas are quite often contaminated with residues of inorganic chemicals left over from metal extraction. Former industrial sites are often sources of groundwater contamination. The contribution presents an example from Southern Bohemia

  5. Current status and future prospect of electron beam sterilization in Japan

    Science.gov (United States)

    Katsura, Ichiro

    1998-06-01

    It seems that electron beam sterilization is being current topic among all applications in Japan and that this tendency will continue until when major companies interested in the technology complete introducing electron beam. Since the Ministry of Health and Welfare(MOHW) officially issued revised regulation on GMP for medical devices in 1995, EtO has become the method regarded as time and money consuming one. On the contrary, electron beam has become as relatively economical and desirable method to achieve same result by its characteristics such as high productivity, rather easy validation and consequent cost reduction, although less penetration limit the kind of products to be treated. Status and prospect of electron beam sterilization in Japan will be presented in the paper along with accelerator related technologies.

  6. Prospecting for coal in China with remote sensing

    Institute of Scientific and Technical Information of China (English)

    TAN Ke-long; WAN Yu-qing; SUN Sun-xin; BAO Gui-bao; KUANG Jing-shui

    2008-01-01

    With the rapid development of China's economy, coal resources are increasingly in great demand. As a result, the remaining coal reserves diminish gradually with large-scale exploitation of coal resources. Easily-found mines which used to be identiffed from outcrops or were buried under shallow overburden are decreasing, especially in the prosperous eastern regions of China,which experience coal shortages. Currently the main targets of coal prospecting are concealed and unidentified underground coal bodies, making it more and more difficult for coal prospecting. It is therefore important to explore coal prospecting by taking advantage of modern remote sensing and geographic information system technologies. Given a theoretical basis for coal prospecting by remote sensing, we demonstrate the methodologies and existing problems systematically by summarizing past practices of coal prospecting with remote sensing. We propose a new theory of coal prospecting with remote sensing. In uncovered areas, coal resources can be prospected for by direct interpretation. In coal beating strata of developed areas covered by thin Quaternary strata or vegetation, prospecting for coal can be carried out by indirect interpretation of geomorphology and vegetation. For deeply buried underground deposits, coal prospecting can rely on tectonic structures, interpretation and analysis of new tectonic clues and regularity of coal formation and preservation controlled by tectonic structures. By applying newly hyper-spectral, multi-polarization, multi-angle, multi-temporal and multi-resolution remote sensing data and carrying out integrated analysis of geographic attributes,ground attributes, geophysical exploration results, geochemical exploration results, geological drilling results and remote sensing data by GIS tools, coal geology resources and mineralogical regularities can be explored and coal resource information can be acquired with some confidence.

  7. A Global Grassland Drought Index (GDI Product: Algorithm and Validation

    Directory of Open Access Journals (Sweden)

    Binbin He

    2015-09-01

    Full Text Available Existing drought indices have been widely used to monitor meteorological drought and agricultural drought; however, few of them are focus on drought monitoring for grassland regions. This study presented a new drought index, the Grassland Drought Index (GDI, for monitoring drought conditions in global grassland regions. These regions are vital for the environment and human society but susceptible to drought. The GDI was constructed based on three measures of water content: precipitation, soil moisture (SM, and canopy water content (CWC. The precipitation information was extracted from the available precipitation datasets, and SM was estimated by downscaling exiting soil moisture data to a 1 km resolution, and CWC was retrieved based on the PROSAIL (PROSPECT + SAIL model. Each variable was scaled from 0 to 1 for each pixel based on absolute minimum and maximum values over time, and these scaled variables were combined with the selected weights to construct the GDI. According to validation at the regional scale, the GDI was correlated with the Standardized Precipitation Index (SPI to some extent, and captured most of the drought area identified by the United States Drought Monitor (USDM maps. In addition, the global GDI product at a 1 km spatial resolution substantially agreed with the global Standardized Precipitation Evapotranspiration Index (SPEI product throughout the period 2005–2010, and it provided detailed and accurate information about the location and the duration of drought based on the evaluation using the known drought events.

  8. Earth Science Enterprise Scientific Data Purchase Project: Verification and Validation

    Science.gov (United States)

    Jenner, Jeff; Policelli, Fritz; Fletcher, Rosea; Holecamp, Kara; Owen, Carolyn; Nicholson, Lamar; Dartez, Deanna

    2000-01-01

    This paper presents viewgraphs on the Earth Science Enterprise Scientific Data Purchase Project's verification,and validation process. The topics include: 1) What is Verification and Validation? 2) Why Verification and Validation? 3) Background; 4) ESE Data Purchas Validation Process; 5) Data Validation System and Ingest Queue; 6) Shipment Verification; 7) Tracking and Metrics; 8) Validation of Contract Specifications; 9) Earth Watch Data Validation; 10) Validation of Vertical Accuracy; and 11) Results of Vertical Accuracy Assessment.

  9. Prospectively Validated Dosing Nomograms for Maximizing the Pharmacodynamics of Vancomycin Administered by Continuous Infusion in Critically Ill Patients▿

    OpenAIRE

    Pea, Federico; Furlanut, Mario; Negri, Camilla; Pavan, Federica; Crapis, Massimo; Cristini, Francesco; Viale, Pierluigi

    2009-01-01

    The efficacy of vancomycin against methicillin-resistant Staphylococcus aureus (MRSA)-related infections has been called into question by recent findings of higher rates of failure of vancomycin treatment of infections caused by strains with high MICs. Continuous infusion may be the best way to maximize the time-dependent activity of vancomycin. The aim of this study was to create dosing nomograms in relation to different creatinine clearance (CLCr) estimates for use in daily clinical practic...

  10. Prospectively validated predictions of shock and organ failure in individual septic surgical patients: the Systemic Mediator Associated Response Test

    OpenAIRE

    Slotman, Gus J

    2000-01-01

    Introduction: Clinically useful predictions of end-organ function and failure in severe sepsis may be possible through analyzing the interactions among demographics, physiologic parameters, standard laboratory tests, and circulating markers of inflammation. The present study evaluated the ability of such a methodology, the Systemic Mediator Associated Response Test (SMART), to predict the clinical course of septic surgery patients from a database of medical and surgical patients with severe s...

  11. Prospective validation and assessment of cardiovascular and offspring risk models for pregnant women with congenital heart disease

    NARCIS (Netherlands)

    Balci, A.; Sollie-Szarynska, K.M.; Bijl, A.G. van der; Ruys, T.P.; Mulder, B.J.; Roos-Hesselink, J.W.; Dijk, A.P.J. van; Wajon, E.M.; Vliegen, H.W.; Drenthen, W.; Hillege, H.L.; Aarnoudse, J.G.; Veldhuisen, D.J. van; Pieper, P.G.

    2014-01-01

    OBJECTIVES: Adequate prepregnancy prediction of maternal cardiovascular and offspring risk is important for counselling and management of pregnancy in women with congenital heart disease (CHD). Therefore we performed a study to identify the optimal assessment strategy for estimating the risk of preg

  12. Prospective validation and assessment of cardiovascular and offspring risk models for pregnant women with congenital heart disease

    NARCIS (Netherlands)

    Balci, Ali; Sollie-Szarynska, Krystyna M.; van der Bijl, Antoinette G. L.; Ruys, Titia P. E.; Mulder, Barbara J. M.; Roos-Hesselink, Jolien W.; van Dijk, Arie P. J.; Wajon, Elly M. C. J.; Vliegen, Hubert W.; Drenthen, Willem; Hillege, Hans L.; Aarnoudse, Jan G.; van Veldhuisen, Dirk J.; Pieper, Petronella G.

    2014-01-01

    Objectives Adequate prepregnancy prediction of maternal cardiovascular and offspring risk is important for counselling and management of pregnancy in women with congenital heart disease (CHD). Therefore we performed a study to identify the optimal assessment strategy for estimating the risk of pregn

  13. Spontaneous abortion: a prospective cohort study of younger women from the general population in Denmark. Validation, occurrence and risk determinants

    DEFF Research Database (Denmark)

    Buss, L; Tolstrup, J; Munk, C;

    2006-01-01

    abortions identified from both sources were recorded in the same year. During follow-up a total of 20.9% of pregnancies intended to be carried to term ended as a spontaneous abortion. In the risk factor analysis, we found that previous spontaneous abortion, being single, never having used oral...... contraceptives, and use of intrauterine device were associated with increased risk of subsequent spontaneous abortion. In addition, it was indicated that a short interpregnancy interval following a spontaneous abortion may confer an increased risk of abortion in the subsequent pregnancy. CONCLUSION: We found......, and may be early, nonhospitalized abortions. We confirm that number of previous spontaneous abortions is a strong determinant, and our data may also indicate a role of previous contraceptive habits. A role of the length of interpregnancy interval in the risk of spontaneous abortion cannot be ruled out....

  14. Design and prospective validation of a dosing instrument for continuous infusion of vancomycin : a within-population approach

    NARCIS (Netherlands)

    van Maarseveen, Erik M.; Bouma, Annemien; Touw, Daniel J.; Neef, Cees; van Zanten, Arthur R.H.

    2014-01-01

    INTRODUCTION: The clinical application of continuous infusion (CoI) of vancomycin has gained interest in recent years. Since no international guidelines on initial dosing of vancomycin CoI exist, there is a need for methods to facilitate the switch from intermittent to continuous vancomycin dosing a

  15. Internal Validity: A Must in Research Designs

    Science.gov (United States)

    Cahit, Kaya

    2015-01-01

    In experimental research, internal validity refers to what extent researchers can conclude that changes in dependent variable (i.e. outcome) are caused by manipulations in independent variable. The causal inference permits researchers to meaningfully interpret research results. This article discusses (a) internal validity threats in social and…

  16. Validating Inductive Hypotheses by Mode Inference

    Institute of Scientific and Technical Information of China (English)

    王志坚

    1993-01-01

    Sme criteria based on mode inference for validating inductive hypotheses are presented in this paper.Mode inference is caried out mechanically,thus such kind of validation can result in low overhead in consistency check and high efficiency in performance.

  17. Microbiological Validation of the IVGEN System

    Science.gov (United States)

    Porter, David A.

    2013-01-01

    The principal purpose of this report is to describe a validation process that can be performed in part on the ground prior to launch, and in space for the IVGEN system. The general approach taken is derived from standard pharmaceutical industry validation schemes modified to fit the special requirements of in-space usage.

  18. Unfolding problem clarification and solution validation

    CERN Document Server

    Gagunashvili, Nikolai

    2016-01-01

    The unfolding problem formulation for correcting experimental data distortions due to finite resolution and limited detector acceptance is discussed. A novel validation of the problem solution is proposed. Attention is drawn to fact that different unfolded distributions may satisfy the validation criteria, in which case a conservative approach using entropy is suggested. The importance of analysis of residuals is demonstrated.

  19. Linear Unlearning for Cross-Validation

    DEFF Research Database (Denmark)

    Hansen, Lars Kai; Larsen, Jan

    1996-01-01

    The leave-one-out cross-validation scheme for generalization assessment of neural network models is computationally expensive due to replicated training sessions. In this paper we suggest linear unlearning of examples as an approach to approximative cross-validation. Further, we discuss the...... time series prediction benchmark demonstrate the potential of the linear unlearning technique...

  20. Validation of a Videoconferenced Speaking Test

    Science.gov (United States)

    Kim, Jungtae; Craig, Daniel A.

    2012-01-01

    Videoconferencing offers new opportunities for language testers to assess speaking ability in low-stakes diagnostic tests. To be considered a trusted testing tool in language testing, a test should be examined employing appropriate validation processes [Chapelle, C.A., Jamieson, J., & Hegelheimer, V. (2003). "Validation of a web-based ESL test."…