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Sample records for based modular laboratory

  1. A Modular and Extensible Remote Electronic Laboratory

    Directory of Open Access Journals (Sweden)

    Giancarlo Parodi

    2005-06-01

    Full Text Available The remote control of instrumentation is not enough to set up a remote laboratory. Several pedagogical, technical, and structural issues must be faced to obtain modular and scalable systems. This paper reports our experience in developing a remote laboratory system to teach electronics to information engineering students. Our target is to develop proper architectures and tools, to obtain an easy management of the system and a better pedagogical effectiveness. The approach used in describing the compo-nents of online experiments facilitates the upgrade of the laboratory and the sharing of experiments, defined as stan-dard learning objects. A particular attention has been paid to pedagogical issues. The main problems being investigated are: the lack of the support that students used to have in traditional labs, the reduced interaction with the objects under test, and the necessity of providing feedback to the experimenters.

  2. Competency Based Modular Experiments in Polymer Science and Technology.

    Science.gov (United States)

    Pearce, Eli M; And Others

    1980-01-01

    Describes a competency-based, modular laboratory course emphasizing the synthesis and characterization of polymers and directed toward senior undergraduate and/or first-year graduate students in science and engineering. One module, free-radical polymerization kinetics by dilatometry, is included as a sample. (CS)

  3. Measuring Modularity in Open Source Code Bases

    Directory of Open Access Journals (Sweden)

    Roberto Milev

    2009-03-01

    Full Text Available Modularity of an open source software code base has been associated with growth of the software development community, the incentives for voluntary code contribution, and a reduction in the number of users who take code without contributing back to the community. As a theoretical construct, modularity links OSS to other domains of research, including organization theory, the economics of industry structure, and new product development. However, measuring the modularity of an OSS design has proven difficult, especially for large and complex systems. In this article, we describe some preliminary results of recent research at Carleton University that examines the evolving modularity of large-scale software systems. We describe a measurement method and a new modularity metric for comparing code bases of different size, introduce an open source toolkit that implements this method and metric, and provide an analysis of the evolution of the Apache Tomcat application server as an illustrative example of the insights gained from this approach. Although these results are preliminary, they open the door to further cross-discipline research that quantitatively links the concerns of business managers, entrepreneurs, policy-makers, and open source software developers.

  4. Environmental sciences and computations: a modular data based systems approach

    International Nuclear Information System (INIS)

    Crawford, T.V.; Bailey, C.E.

    1975-07-01

    A major computer code for environmental calculations is under development at the Savannah River Laboratory. The primary aim is to develop a flexible, efficient capability to calculate, for all significant pathways, the dose to man resulting from releases of radionuclides from the Savannah River Plant and from other existing and potential radioactive sources in the southeastern United States. The environmental sciences programs at SRP are described, with emphasis on the development of the calculational system. It is being developed as a modular data-based system within the framework of the larger JOSHUA Computer System, which provides data management, terminal, and job execution facilities. (U.S.)

  5. MODULAR ANALYTICS: A New Approach to Automation in the Clinical Laboratory

    OpenAIRE

    Horowitz, Gary L.; Zaman, Zahur; Blanckaert, Norbert J. C.; Chan, Daniel W.; Dubois, Jeffrey A.; Golaz, Olivier; Mensi, Noury; Keller, Franz; Stolz, Herbert; Klingler, Karl; Marocchi, Alessandro; Prencipe, Lorenzo; McLawhon, Ronald W.; Nilsen, Olaug L.; Oellerich, Michael

    2005-01-01

    MODULAR ANALYTICS (Roche Diagnostics) (MODULAR ANALYTICS, Elecsys and Cobas Integra are trademarks of a member of the Roche Group) represents a new approach to automation for the clinical chemistry laboratory. It consists of a control unit, a core unit with a bidirectional multitrack rack transportation system, and three distinct kinds of analytical modules: an ISE module, a P800 module (44 photometric tests, throughput of up to 800 tests/h), and a D2400 module (16 photometric tests, throughp...

  6. MODULAR ANALYTICS: A New Approach to Automation in the Clinical Laboratory.

    Science.gov (United States)

    Horowitz, Gary L; Zaman, Zahur; Blanckaert, Norbert J C; Chan, Daniel W; Dubois, Jeffrey A; Golaz, Olivier; Mensi, Noury; Keller, Franz; Stolz, Herbert; Klingler, Karl; Marocchi, Alessandro; Prencipe, Lorenzo; McLawhon, Ronald W; Nilsen, Olaug L; Oellerich, Michael; Luthe, Hilmar; Orsonneau, Jean-Luc; Richeux, Gérard; Recio, Fernando; Roldan, Esther; Rymo, Lars; Wicktorsson, Anne-Charlotte; Welch, Shirley L; Wieland, Heinrich; Grawitz, Andrea Busse; Mitsumaki, Hiroshi; McGovern, Margaret; Ng, Katherine; Stockmann, Wolfgang

    2005-01-01

    MODULAR ANALYTICS (Roche Diagnostics) (MODULAR ANALYTICS, Elecsys and Cobas Integra are trademarks of a member of the Roche Group) represents a new approach to automation for the clinical chemistry laboratory. It consists of a control unit, a core unit with a bidirectional multitrack rack transportation system, and three distinct kinds of analytical modules: an ISE module, a P800 module (44 photometric tests, throughput of up to 800 tests/h), and a D2400 module (16 photometric tests, throughput up to 2400 tests/h). MODULAR ANALYTICS allows customised configurations for various laboratory workloads. The performance and practicability of MODULAR ANALYTICS were evaluated in an international multicentre study at 16 sites. Studies included precision, accuracy, analytical range, carry-over, and workflow assessment. More than 700 000 results were obtained during the course of the study. Median between-day CVs were typically less than 3% for clinical chemistries and less than 6% for homogeneous immunoassays. Median recoveries for nearly all standardised reference materials were within 5% of assigned values. Method comparisons versus current existing routine instrumentation were clinically acceptable in all cases. During the workflow studies, the work from three to four single workstations was transferred to MODULAR ANALYTICS, which offered over 100 possible methods, with reduction in sample splitting, handling errors, and turnaround time. Typical sample processing time on MODULAR ANALYTICS was less than 30 minutes, an improvement from the current laboratory systems. By combining multiple analytic units in flexible ways, MODULAR ANALYTICS met diverse laboratory needs and offered improvement in workflow over current laboratory situations. It increased overall efficiency while maintaining (or improving) quality.

  7. Anatomy-Based Organization of Modular Robots

    DEFF Research Database (Denmark)

    Christensen, David Johan; Campbell, Jason

    2008-01-01

    This paper presents a novel biologically inspired hierarchical approach to organizing and controlling modular robots. The purpose of our approach is to decompose the complexity of assembling and commanding a functional robot made of numerous simple modules (thousands to millions) by introducing...... a hierarchy of structure and control. The robots we describe incorporate anatomically inspired parts such as muscles, bones and joints, and these parts in turn are assembled from modules. Each of those parts encapsulates one or more functions, e.g. a muscle can contract. Control of the robot can then be cast...

  8. Modular adaptive implant based on smart materials.

    Science.gov (United States)

    Bîzdoacă, N; Tarniţă, Daniela; Tarniţă, D N

    2008-01-01

    Applications of biological methods and systems found in nature to the study and design of engineering systems and modern technology are defined as Bionics. The present paper describes a bionics application of shape memory alloy in construction of orthopedic implant. The main idea of this paper is related to design modular adaptive implants for fractured bones. In order to target the efficiency of medical treatment, the implant has to protect the fractured bone, for the healing period, undertaking much as is possible from the daily usual load of the healthy bones. After a particular stage of healing period is passed, using implant modularity, the load is gradually transferred to bone, assuring in this manner a gradually recover of bone function. The adaptability of this design is related to medical possibility of the physician to made the implant to correspond to patient specifically anatomy. Using a CT realistic numerical bone models, the mechanical simulation of different types of loading of the fractured bones treated with conventional method are presented. The results are commented and conclusions are formulated.

  9. Understanding Project Based Production through Socio-technical Modularity

    DEFF Research Database (Denmark)

    Thuesen, Christian Langhoff

    This paper develops an approach for understanding Project Based Production. This form of production is characterized by unique deliverables, high complexity, high value, high risk, profound uncertainty and many stakeholders and is increasingly important the postmodern society. Common...... with the starting point in system theory and a strong bias towards industrial production, the predominant understanding of modularity faces difficulty in explaining practices of Project Based Production in both social – technical and dynamic – stable aspects. Illustrated by a case the paper addresses this gap...... as an entanglement of product, process, organizational and institutional modularity. The paper concludes proposing central questions for the development of the concept of modularity for understanding, designing and managing of PBP....

  10. Design and Construction of a Modular Lunar Base

    Science.gov (United States)

    Grandl, Dipl. Ing Werner

    DESIGN and CONSTRUCTION of a MODULAR LUNAR BASE Purpose: The Lunar Base Design Study is a concept for the return of humans from 2020 to the end of the century. Structure: The proposed lunar station is built of 6 cylindrical modules, each one 17 m long and 6 m in diameter. Each module is made of aluminium sheets and trapezoidal aluminium sheeting and has a weight (on earth) of approx.10.2 tonnes, including the interior equipment and furnishing. The outer wall of the cylinders is built as a double-shell system, stiffened by radial bulkheads. 8 astronauts or scientists can live and work in the station, using the modules as follows: -1 Central Living Module -2 Living Quater Modules, with private rooms for each person -1 Laboratory Module for scientific research and engineering -1 Airlock Module, containing outdoor equipment, space suits, etc. -1 Energy Plant Module, carrying solar panels a small nuclear reactor and antennas for communication. Shielding: To protect the astronauts micrometeorites and radiation, the caves between the two shells of the outer wall are filled with a 0.6 m thick layer or regolith in situ by a small teleoperated digger vehicle. Using lunar material for shielding the payload for launching can be minimized. Launch and Transport: For launching a modified ARIANE 5 launcher or similar US, Russian, Chinese or Indian rockets can be used. For the flight from Earth Orbit to Lunar Orbit a "Space-Tug", which is deployed in Earth Orbit, can be used. To land the modules on the lunar surface a "Teleoperated Rocket Crane" has been developed by the author. This vehicle will be assembled in lunar orbit and is built as a structural framework, carrying rocket engines, fuel tanks and teleoperated crawlers to move the modules on the lunar surface. To establish this basic stage of the Lunar Base 11 launches are necessary: -1 Lunar Orbiter, a small manned spaceship (3 astronauts) -1 Manned Lander and docking module for the orbiter -1 Teleoperated Rocket Crane -6

  11. Comparison of single and modular ANN based fault detector and ...

    African Journals Online (AJOL)

    user

    Abstract. Comparison of single and modular artificial neural network based techniques for shunt faults detection and classification in double end fed double circuit transmission line is presented in this paper. The proposed method uses the voltages and currents signals available at the local end of line. The model of the ...

  12. Flexible, fpga-based electronics for modular robots

    DEFF Research Database (Denmark)

    Brandt, David; Larsen, Jørgen Christian; Christensen, David Johan

    2008-01-01

    In this paper we introduce electronics for the ATRON self-reconfigurable robot based on field programmable gate arrays (FPGAs). The immediate advantage of using FPGAs is that some of the module’s electronics can be moved into the FPGA, thereby the number of components can be reduced. In the case...... consumption compared to micro-controllers. However, overall FPGAs make the electronics of modular robots more flexible and therefore may make them more suitable for real applications. AB - In this paper we introduce electronics for the ATRON self-reconfigurable robot based on field programmable gate arrays...... the electronics for specific tasks. The disadvantages of an FPGA-based design include the cost of FPGAs, the extra layer of complexity in programming, and a limited increase in power consumption compared to micro-controllers. However, overall FPGAs make the electronics of modular robots more flexible...

  13. A large stellarator based on modular coils

    International Nuclear Information System (INIS)

    Hamberger, S.M.; Sharp, L.E.; Petersen, L.F.

    1979-06-01

    Although stellarators offer some considerable advantages over tokamaks, difficulties arise in designing large devices due, for instance, to poor plasma access as well as to constructional electromechanical and maintenance problems associated with continous helical windings. This paper describes a design for a fairly large device (major radius 2.1m), based on a set of discrete coil modules arranged in a toroidal configuration to provide the required closed magnetic surfaces, having gaps for unobstructed access to the plasma for diagnostics, etc, and allowing for easy removal for maintenance

  14. ADVANCED SEISMIC BASE ISOLATION METHODS FOR MODULAR REACTORS

    International Nuclear Information System (INIS)

    Blanford, E.; Keldrauk, E.; Laufer, M.; Mieler, M.; Wei, J.; Stojadinovic, B.; Peterson, P.F.

    2010-01-01

    Advanced technologies for structural design and construction have the potential for major impact not only on nuclear power plant construction time and cost, but also on the design process and on the safety, security and reliability of next generation of nuclear power plants. In future Generation IV (Gen IV) reactors, structural and seismic design should be much more closely integrated with the design of nuclear and industrial safety systems, physical security systems, and international safeguards systems. Overall reliability will be increased, through the use of replaceable and modular equipment, and through design to facilitate on-line monitoring, in-service inspection, maintenance, replacement, and decommissioning. Economics will also receive high design priority, through integrated engineering efforts to optimize building arrangements to minimize building heights and footprints. Finally, the licensing approach will be transformed by becoming increasingly performance based and technology neutral, using best-estimate simulation methods with uncertainty and margin quantification. In this context, two structural engineering technologies, seismic base isolation and modular steel-plate/concrete composite structural walls, are investigated. These technologies have major potential to (1) enable standardized reactor designs to be deployed across a wider range of sites, (2) reduce the impact of uncertainties related to site-specific seismic conditions, and (3) alleviate reactor equipment qualification requirements. For Gen IV reactors the potential for deliberate crashes of large aircraft must also be considered in design. This report concludes that base-isolated structures should be decoupled from the reactor external event exclusion system. As an example, a scoping analysis is performed for a rectangular, decoupled external event shell designed as a grillage. This report also reviews modular construction technology, particularly steel-plate/concrete construction using

  15. ADVANCED SEISMIC BASE ISOLATION METHODS FOR MODULAR REACTORS

    Energy Technology Data Exchange (ETDEWEB)

    E. Blanford; E. Keldrauk; M. Laufer; M. Mieler; J. Wei; B. Stojadinovic; P.F. Peterson

    2010-09-20

    Advanced technologies for structural design and construction have the potential for major impact not only on nuclear power plant construction time and cost, but also on the design process and on the safety, security and reliability of next generation of nuclear power plants. In future Generation IV (Gen IV) reactors, structural and seismic design should be much more closely integrated with the design of nuclear and industrial safety systems, physical security systems, and international safeguards systems. Overall reliability will be increased, through the use of replaceable and modular equipment, and through design to facilitate on-line monitoring, in-service inspection, maintenance, replacement, and decommissioning. Economics will also receive high design priority, through integrated engineering efforts to optimize building arrangements to minimize building heights and footprints. Finally, the licensing approach will be transformed by becoming increasingly performance based and technology neutral, using best-estimate simulation methods with uncertainty and margin quantification. In this context, two structural engineering technologies, seismic base isolation and modular steel-plate/concrete composite structural walls, are investigated. These technologies have major potential to (1) enable standardized reactor designs to be deployed across a wider range of sites, (2) reduce the impact of uncertainties related to site-specific seismic conditions, and (3) alleviate reactor equipment qualification requirements. For Gen IV reactors the potential for deliberate crashes of large aircraft must also be considered in design. This report concludes that base-isolated structures should be decoupled from the reactor external event exclusion system. As an example, a scoping analysis is performed for a rectangular, decoupled external event shell designed as a grillage. This report also reviews modular construction technology, particularly steel-plate/concrete construction using

  16. Assembly of a Modular Fluorimeter and Associated Software: Using LabVIEW in an Advanced Undergraduate Analytical Chemistry Laboratory

    Science.gov (United States)

    Algar, W. Russ; Massey, Melissa; Krull, Ulrich J.

    2009-01-01

    A laboratory activity for an upper-level undergraduate course in instrumental analysis has been created around LabVIEW. Students learn rudimentary programming and interfacing skills during the construction of a fluorimeter assembled from common modular components. The fluorimeter consists of an inexpensive data acquisition module, LED light…

  17. South African Ebola diagnostic response in Sierra Leone: A modular high biosafety field laboratory.

    Science.gov (United States)

    Paweska, Janusz T; Jansen van Vuren, Petrus; Meier, Gunther H; le Roux, Chantel; Conteh, Ousman S; Kemp, Alan; Fourie, Cardia; Naidoo, Prabha; Naicker, Serisha; Ohaebosim, Phumza; Storm, Nadia; Hellferscee, Orienka; Ming Sun, Lisa K; Mogodi, Busisiwe; Prabdial-Sing, Nishi; du Plessis, Desiree; Greyling, Deidre; Loubser, Shayne; Goosen, Mark; McCulloch, Stewart D; Scott, Terence P; Moerdyk, Alexandra; Dlamini, Wesley; Konneh, Kelfala; Kamara, Idrissa L; Sowa, Dauda; Sorie, Samuel; Kargbo, Brima; Madhi, Shabir A

    2017-06-01

    In August 2014, the National Institute for Communicable Diseases (NICD) in South Africa established a modular high-biosafety field Ebola diagnostic laboratory (SA FEDL) near Freetown, Sierra Leone in response to the rapidly increasing number of Ebola virus disease (EVD) cases. The SA FEDL operated in the Western Area of Sierra Leone, which remained a "hotspot" of the EVD epidemic for months. The FEDL was the only diagnostic capacity available to respond to the overwhelming demand for rapid EVD laboratory diagnosis for several weeks in the initial stages of the EVD crisis in the capital of Sierra Leone. Furthermore, the NICD set out to establish local capacity amongst Sierra Leonean nationals in all aspects of the FEDL functions from the outset. This led to the successful hand-over of the FEDL to the Sierra Leone Ministry of Health and Sanitation in March 2015. Between 25 August 2014 and 22 June 2016, the laboratory tested 11,250 specimens mostly from the Western Urban and Western Rural regions of Sierra Leone, of which 2,379 (21.14%) tested positive for Ebola virus RNA. The bio-safety standards and the portability of the SA FEDL, offered a cost-effective and practical alternative for the rapid deployment of a field-operated high biocontainment facility. The SA FEDL teams demonstrated that it is highly beneficial to train the national staff in the course of formidable disease outbreak and accomplished their full integration into all operational and diagnostic aspects of the laboratory. This initiative contributed to the international efforts in bringing the EVD outbreak under control in Sierra Leone, as well as capacitating local African scientists and technologists to respond to diagnostic needs that might be required in future outbreaks of highly contagious pathogens.

  18. A modular positive feedback-based gene amplifier

    Directory of Open Access Journals (Sweden)

    Bhalerao Kaustubh D

    2010-02-01

    Full Text Available Abstract Background Positive feedback is a common mechanism used in the regulation of many gene circuits as it can amplify the response to inducers and also generate binary outputs and hysteresis. In the context of electrical circuit design, positive feedback is often considered in the design of amplifiers. Similar approaches, therefore, may be used for the design of amplifiers in synthetic gene circuits with applications, for example, in cell-based sensors. Results We developed a modular positive feedback circuit that can function as a genetic signal amplifier, heightening the sensitivity to inducer signals as well as increasing maximum expression levels without the need for an external cofactor. The design utilizes a constitutively active, autoinducer-independent variant of the quorum-sensing regulator LuxR. We experimentally tested the ability of the positive feedback module to separately amplify the output of a one-component tetracycline sensor and a two-component aspartate sensor. In each case, the positive feedback module amplified the response to the respective inducers, both with regards to the dynamic range and sensitivity. Conclusions The advantage of our design is that the actual feedback mechanism depends only on a single gene and does not require any other modulation. Furthermore, this circuit can amplify any transcriptional signal, not just one encoded within the circuit or tuned by an external inducer. As our design is modular, it can potentially be used as a component in the design of more complex synthetic gene circuits.

  19. Evaluation of Rule-based Modularization in Model Transformation Languages illustrated with ATL

    NARCIS (Netherlands)

    Ivanov, Ivan; van den Berg, Klaas; Jouault, Frédéric

    This paper studies ways for modularizing transformation definitions in current rule-based model transformation languages. Two scenarios are shown in which the modular units are identified on the base of the relations between source and target metamodels and on the base of generic transformation

  20. Rule-based modularization in model transformation languages illustrated with ATL

    NARCIS (Netherlands)

    Ivanov, Ivan; van den Berg, Klaas; Jouault, Frédéric

    2007-01-01

    This paper studies ways for modularizing transformation definitions in current rule-based model transformation languages. Two scenarios are shown in which the modular units are identified on the basis of relations between source and target metamodels and on the base of generic transformation

  1. The Potential for Computer Based Systems in Modular Engineering

    DEFF Research Database (Denmark)

    Miller, Thomas Dedenroth

    1998-01-01

    The paper elaborates on knowledge management and the possibility for computer support of the design process of pharmaceutical production plants in relation to the ph.d. project modular engineering.......The paper elaborates on knowledge management and the possibility for computer support of the design process of pharmaceutical production plants in relation to the ph.d. project modular engineering....

  2. TRIZ based Interface conflict resolving strategies for modular product architectures

    NARCIS (Netherlands)

    Wits, Wessel Willems; Vaneker, Thomas H.J.; Rizzi, C.

    2010-01-01

    In product development, the chosen product architecture often possesses characteristics of both modular and integral design. Within a modular architecture, a Function-Behavior-Structure (FBS) model has been applied to describe modules and their interfaces. To resolve emerging interface conflicts,

  3. Model-based Kinematics Generation for Modular Mechatronic Toolkits

    DEFF Research Database (Denmark)

    Bordignon, M.; Schultz, U. P.; Stoy, K.

    2011-01-01

    Modular robots are mechatronic devices that enable the construction of highly versatile and flexible robotic systems whose mechanical structure can be dynamically modified. The key feature that enables this dynamic modification is the capability of the individual modules to connect to each other...... in multiple ways and thus generate a number of different mechanical systems, in contrast with the monolithic, fixed structure of conventional robots. The mechatronic flexibility, however, complicates the development of models and programming abstractions for modular robots, since manually describing...... the Modular Mechatronics Modelling Language (M3L). M3L is a domain-specific language, which can model the kinematic structure of individual robot modules and declaratively describe their possible interconnections, rather than requiring the user to enumerate them in their entirety. From this description, the M...

  4. The Los Alamos VXI-based modular RF control system

    Energy Technology Data Exchange (ETDEWEB)

    Jachim, S.P.; Ziomek, C.; Natter, E.F.; Regan, A.H.; Hill, J.; Eaton, L.; Gutscher, W.D.; Curtin, M.; Denney, P.; Hansberry, E.; Brooks, T.

    1993-01-01

    This paper describes the design and implementation of the Los Alamos modular RF control system, which provides high-performance feedback and/or feedforward control of RF accelerator cavities. This is a flexible, modular control system which has been realized in the industry-standard VXI cardmodular format. A wide spectrum of system functionality can be accommodated simply by incorporating only those modules and features required for a particular application. The fundamental principles of the design approach are discussed. Details of the VXI implementation are given, including the system architecture and interfaces, performance capabilities, and available features.

  5. The Los Alamos VXI-based modular RF control system

    Energy Technology Data Exchange (ETDEWEB)

    Jachim, S.P.; Ziomek, C.; Natter, E.F.; Regan, A.H.; Hill, J.; Eaton, L.; Gutscher, W.D.; Curtin, M.; Denney, P.; Hansberry, E.; Brooks, T.

    1993-06-01

    This paper describes the design and implementation of the Los Alamos modular RF control system, which provides high-performance feedback and/or feedforward control of RF accelerator cavities. This is a flexible, modular control system which has been realized in the industry-standard VXI cardmodular format. A wide spectrum of system functionality can be accommodated simply by incorporating only those modules and features required for a particular application. The fundamental principles of the design approach are discussed. Details of the VXI implementation are given, including the system architecture and interfaces, performance capabilities, and available features.

  6. Modular finger and hand motion capturing system based on inertial and magnetic sensors

    Directory of Open Access Journals (Sweden)

    Valtin Markus

    2017-03-01

    Full Text Available The assessment of hand posture and kinematics is increasingly important in various fields. This includes the rehabilitation of stroke survivors with restricted hand function. This paper presents a modular, ambulatory measurement system for the assement of the remaining hand function and for closed-loop controlled therapy. The device is based on inertial sensors and utilizes up to five interchangeable sensor strips to achieve modularity and to simplify the sensor attachment. We introduce the modular hardware design and describe algorithms used to calculate the joint angles. Measurements with two experimental setups demonstrate the feasibility and the potential of such a tracking device.

  7. Segment LLL Reduction of Lattice Bases Using Modular Arithmetic

    Directory of Open Access Journals (Sweden)

    Sanjay Mehrotra

    2010-07-01

    Full Text Available The algorithm of Lenstra, Lenstra, and Lovász (LLL transforms a given integer lattice basis into a reduced basis. Storjohann improved the worst case complexity of LLL algorithms by a factor of O(n using modular arithmetic. Koy and Schnorr developed a segment-LLL basis reduction algorithm that generates lattice basis satisfying a weaker condition than the LLL reduced basis with O(n improvement than the LLL algorithm. In this paper we combine Storjohann’s modular arithmetic approach with the segment-LLL approach to further improve the worst case complexity of the segment-LLL algorithms by a factor of n0.5.

  8. Ontology Alignment Repair through Modularization and Confidence-Based Heuristics.

    Directory of Open Access Journals (Sweden)

    Emanuel Santos

    Full Text Available Ontology Matching aims at identifying a set of semantic correspondences, called an alignment, between related ontologies. In recent years, there has been a growing interest in efficient and effective matching methods for large ontologies. However, alignments produced for large ontologies are often logically incoherent. It was only recently that the use of repair techniques to improve the coherence of ontology alignments began to be explored. This paper presents a novel modularization technique for ontology alignment repair which extracts fragments of the input ontologies that only contain the necessary classes and relations to resolve all detectable incoherences. The paper presents also an alignment repair algorithm that uses a global repair strategy to minimize both the degree of incoherence and the number of mappings removed from the alignment, while overcoming the scalability problem by employing the proposed modularization technique. Our evaluation shows that our modularization technique produces significantly small fragments of the ontologies and that our repair algorithm produces more complete alignments than other current alignment repair systems, while obtaining an equivalent degree of incoherence. Additionally, we also present a variant of our repair algorithm that makes use of the confidence values of the mappings to improve alignment repair. Our repair algorithm was implemented as part of AgreementMakerLight, a free and open-source ontology matching system.

  9. Ontology Alignment Repair through Modularization and Confidence-Based Heuristics.

    Science.gov (United States)

    Santos, Emanuel; Faria, Daniel; Pesquita, Catia; Couto, Francisco M

    2015-01-01

    Ontology Matching aims at identifying a set of semantic correspondences, called an alignment, between related ontologies. In recent years, there has been a growing interest in efficient and effective matching methods for large ontologies. However, alignments produced for large ontologies are often logically incoherent. It was only recently that the use of repair techniques to improve the coherence of ontology alignments began to be explored. This paper presents a novel modularization technique for ontology alignment repair which extracts fragments of the input ontologies that only contain the necessary classes and relations to resolve all detectable incoherences. The paper presents also an alignment repair algorithm that uses a global repair strategy to minimize both the degree of incoherence and the number of mappings removed from the alignment, while overcoming the scalability problem by employing the proposed modularization technique. Our evaluation shows that our modularization technique produces significantly small fragments of the ontologies and that our repair algorithm produces more complete alignments than other current alignment repair systems, while obtaining an equivalent degree of incoherence. Additionally, we also present a variant of our repair algorithm that makes use of the confidence values of the mappings to improve alignment repair. Our repair algorithm was implemented as part of AgreementMakerLight, a free and open-source ontology matching system.

  10. KINEMATIC ANALYSIS OF MODULAR, TRUSS-BASED MANIPULATOR UNITS

    Energy Technology Data Exchange (ETDEWEB)

    Salerno, R. J.

    1994-06-01

    Decontamination and Dismantling (D&D) activities within the U.S. Department of Energy (DOE) require a long reach manipulator with a large load capacity. Variable Geometry Trusses (VGTs) are a unique class of mechanical structures which allow the advantages of truss structures for large scale applications to be applied to large robotic manipulators. Individual VGT units may be assembled to create a modular, long-reach, truss-type manipulator. Each module of such a manipulator system is either a static truss section or one of several possible VGT geometries. While many potential applications exist for this technology, the present work is largely motivated by the need for generic robotic systems for remote manipulation. A manipulator system based on VGT modules provides several advantages. The reconfigurable nature of the manipulator system allows it to be adapted on site to unforeseen conditions. The kinematic redundancy of the manipulator enables it to work effectively even in a highly obstructed workspace. The parallel structure of the truss modules enables the manipulator to be withdrawn in the event of a structural failure. Finally, the open framework of the modules provides a clear, protected passageway for control and power cabling, waste conveyance, or other services required at the end effector. As is implied in a truss structure, all primary members of a VGT are ideally loaded in pure tension or compression. This results in an extremely stiff and strong manipulator system with minimal overall weight. Careful design of the joints of a VGT is very important to the overall stiffness and accuracy of the structure, as several links (as many as six) are joined together at each joint. The greatest disadvantage to this approach to manipulator design has traditionally been that the kinematics of VGT structures are complex and poorly understood. This report specifically addresses the kinematics of several possible geometries for the individual VGT units. Equations and

  11. Integrating Streaming Media to Web-based Learning: A Modular Approach.

    Science.gov (United States)

    Miltenoff, Plamen

    2000-01-01

    Explains streaming technology and discusses how to integrate it into Web-based instruction based on experiences at St. Cloud State University (Minnesota). Topics include a modular approach, including editing, copyright concerns, digitizing, maintenance, and continuing education needs; the role of the library; and how streaming can enhance…

  12. A Power Sharing Method Based on Modified Droop Control for Modular UPS

    DEFF Research Database (Denmark)

    Wei, Baoze; Liu, Wenzhao; Guerrero, Josep M.

    2017-01-01

    An average power sharing control strategy for parallel operation of voltage source inverter (VSI) based modular Uninterruptible Power Systems (UPSs) is proposed in this paper. The presented method is based on a modified droop control. The proposed method conquers the drawback of conventional droop...

  13. Complexity in Managing Modularization

    DEFF Research Database (Denmark)

    Hansen, Poul H. Kyvsgård; Sun, Hongyi

    2011-01-01

    In general, the phenomenon of managing modularization is not well known. The cause-effect relationships between modularization and realized benefits are complex and comprehensive. Though a number of research works have contributed to the study of the phenomenon of efficient and effective...... modularization management it is far from clarified. Recognizing the need for further empirical research, we have studied 40 modularity cases in various companies. The studies have been designed as long-term studies leaving time for various types of modularization benefits to emerge. Based on these studies we...... have developed a framework to support the heuristic and iterative process of planning and realizing modularization benefits....

  14. Computer simulation of thermal and fluid systems for MIUS integration and subsystems test /MIST/ laboratory. [Modular Integrated Utility System

    Science.gov (United States)

    Rochelle, W. C.; Liu, D. K.; Nunnery, W. J., Jr.; Brandli, A. E.

    1975-01-01

    This paper describes the application of the SINDA (systems improved numerical differencing analyzer) computer program to simulate the operation of the NASA/JSC MIUS integration and subsystems test (MIST) laboratory. The MIST laboratory is designed to test the integration capability of the following subsystems of a modular integrated utility system (MIUS): (1) electric power generation, (2) space heating and cooling, (3) solid waste disposal, (4) potable water supply, and (5) waste water treatment. The SINDA/MIST computer model is designed to simulate the response of these subsystems to externally impressed loads. The computer model determines the amount of recovered waste heat from the prime mover exhaust, water jacket and oil/aftercooler and from the incinerator. This recovered waste heat is used in the model to heat potable water, for space heating, absorption air conditioning, waste water sterilization, and to provide for thermal storage. The details of the thermal and fluid simulation of MIST including the system configuration, modes of operation modeled, SINDA model characteristics and the results of several analyses are described.

  15. Activity-based costing as a method for assessing the economics of modularization

    DEFF Research Database (Denmark)

    Thyssen, Jesper; Israelsen, Poul; Jørgensen, Brian

    2006-01-01

    The paper accounts for an Activity-Based Costing (ABC) analysis supporting decision-making concerning product modularity. The ABC analysis carried out is communicated to decision-makers by telling how much higher the variable cost of the multi-purpose module can be compared to the average variabl...

  16. Improving long-term care provision: towards demand-based care by means of modularity

    Directory of Open Access Journals (Sweden)

    Meijboom Bert

    2010-09-01

    Full Text Available Abstract Background As in most fields of health care, societal and political changes encourage suppliers of long-term care to put their clients at the center of care and service provision and become more responsive towards client needs and requirements. However, the diverse, multiple and dynamic nature of demand for long-term care complicates the movement towards demand-based care provision. This paper aims to advance long-term care practice and, to that end, examines the application of modularity. This concept is recognized in a wide range of product and service settings for its ability to design demand-based products and processes. Methods Starting from the basic dimensions of modularity, we use qualitative research to explore the use and application of modularity principles in the current working practices and processes of four organizations in the field of long-term care for the elderly. In-depth semi-structured interviews were conducted with 38 key informants and triangulated with document research and observation. Data was analyzed thematically by means of coding and subsequent exploration of patterns. Data analysis was facilitated by qualitative analysis software. Results Our data suggest that a modular setup of supply is employed in the arrangement of care and service supply and assists providers of long-term care in providing their clients with choice options and variation. In addition, modularization of the needs assessment and package specification process allows the case organizations to manage client involvement but still provide customized packages of care and services. Conclusion The adequate setup of an organization's supply and its specification phase activities are indispensible for long-term care providers who aim to do better in terms of quality and efficiency. Moreover, long-term care providers could benefit from joint provision of care and services by means of modular working teams. Based upon our findings, we are able to

  17. Inertial measurement unit–based iterative pose compensation algorithm for low-cost modular manipulator

    Directory of Open Access Journals (Sweden)

    Yunhan Lin

    2016-01-01

    Full Text Available It is a necessary mean to realize the accurate motion control of the manipulator which uses end-effector pose correction method and compensation method. In this article, first, we established the kinematic model and error model of the modular manipulator (WUST-ARM, and then we discussed the measurement methods and precision of the inertial measurement unit sensor. The inertial measurement unit sensor is mounted on the end-effector of modular manipulator, to get the real-time pose of the end-effector. At last, a new inertial measurement unit–based iterative pose compensation algorithm is proposed. By applying this algorithm in the pose compensation experiment of modular manipulator which is composed of low-cost rotation joints, the results show that the inertial measurement unit can obtain a higher precision when in static state; it will accurately feedback to the control system with an accurate error compensation angle after a brief delay when the end-effector moves to the target point, and after compensation, the precision errors of roll angle, pitch angle, and yaw angle are reached at 0.05°, 0.01°, and 0.27° respectively. It proves that this low-cost method provides a new solution to improve the end-effector pose of low-cost modular manipulator.

  18. A modularized operator interface framework for Tokamak based on MVC design pattern

    International Nuclear Information System (INIS)

    Yin, Xuan; Zheng, Wei; Zhang, Ming; Zhang, Jing; Zhuang, G.; Ding, T.

    2014-01-01

    Highlights: • Our framework is based on MVC design pattern. • XML is used to cope with minor difference between different applications. • Functions dealing with EPICS and MDSplus have been modularized into reusable modules. • The modularized framework will shorten J-TEXT's software development cycle. - Abstract: Facing various and continually changing experimental needs, the J-TEXT Tokamak experiment requires home-made software applications developed for different sub-systems. Though dealing with different specific problems, these software applications usually share a lot of functionalities in common. With the goal of improving the productivity of research groups, J-TEXT has designed a C# desktop application framework which is mainly focused on operator interface development. Following the Model–View–Controller (MVC) design pattern, the main functionality dealing with Experimental Physics and Industrial Control System (EPICS) or MDSplus has been modularized into reusable modules. Minor difference among applications can be coped with XML configuration files. In this case, developers are able to implement various kinds of operator interface without knowing the implementation details of the bottom functions in Models, mainly focusing on Views and Controllers. This paper presents J-TEXT C# desktop application framework, introducing the technology of fast development of the modularized operator interface. Some experimental applications designed in this framework have been already deployed in J-TEXT, and will be introduced in this paper

  19. A modularized operator interface framework for Tokamak based on MVC design pattern

    Energy Technology Data Exchange (ETDEWEB)

    Yin, Xuan; Zheng, Wei [State Key Laboratory of Advanced Electromagnetic Engineering and Technology, Huazhong University of Science and Technology, Wuhan 430074 (China); College of Electrical and Electronic Engineering, Huazhong University of Science and Technology, Wuhan 430074 (China); Zhang, Ming, E-mail: zhangming@hust.edu.cn [State Key Laboratory of Advanced Electromagnetic Engineering and Technology, Huazhong University of Science and Technology, Wuhan 430074 (China); College of Electrical and Electronic Engineering, Huazhong University of Science and Technology, Wuhan 430074 (China); Zhang, Jing; Zhuang, G.; Ding, T. [State Key Laboratory of Advanced Electromagnetic Engineering and Technology, Huazhong University of Science and Technology, Wuhan 430074 (China); College of Electrical and Electronic Engineering, Huazhong University of Science and Technology, Wuhan 430074 (China)

    2014-05-15

    Highlights: • Our framework is based on MVC design pattern. • XML is used to cope with minor difference between different applications. • Functions dealing with EPICS and MDSplus have been modularized into reusable modules. • The modularized framework will shorten J-TEXT's software development cycle. - Abstract: Facing various and continually changing experimental needs, the J-TEXT Tokamak experiment requires home-made software applications developed for different sub-systems. Though dealing with different specific problems, these software applications usually share a lot of functionalities in common. With the goal of improving the productivity of research groups, J-TEXT has designed a C# desktop application framework which is mainly focused on operator interface development. Following the Model–View–Controller (MVC) design pattern, the main functionality dealing with Experimental Physics and Industrial Control System (EPICS) or MDSplus has been modularized into reusable modules. Minor difference among applications can be coped with XML configuration files. In this case, developers are able to implement various kinds of operator interface without knowing the implementation details of the bottom functions in Models, mainly focusing on Views and Controllers. This paper presents J-TEXT C# desktop application framework, introducing the technology of fast development of the modularized operator interface. Some experimental applications designed in this framework have been already deployed in J-TEXT, and will be introduced in this paper.

  20. Product Architecture Modularity Strategies

    DEFF Research Database (Denmark)

    Mikkola, Juliana Hsuan

    2003-01-01

    The focus of this paper is to integrate various perspectives on product architecture modularity into a general framework, and also to propose a way to measure the degree of modularization embedded in product architectures. Various trade-offs between modular and integral product architectures...... and how components and interfaces influence the degree of modularization are considered. In order to gain a better understanding of product architecture modularity as a strategy, a theoretical framework and propositions are drawn from various academic literature sources. Based on the literature review...

  1. Product Architecture Modularity Strategies

    DEFF Research Database (Denmark)

    Mikkola, Juliana Hsuan

    2003-01-01

    and how components and interfaces influence the degree of modularization are considered. In order to gain a better understanding of product architecture modularity as a strategy, a theoretical framework and propositions are drawn from various academic literature sources. Based on the literature review......The focus of this paper is to integrate various perspectives on product architecture modularity into a general framework, and also to propose a way to measure the degree of modularization embedded in product architectures. Various trade-offs between modular and integral product architectures......, the following key elements of product architecture are identified: components (standard and new-to-the-firm), interfaces (standardization and specification), degree of coupling, and substitutability. A mathematical function, termed modularization function, is introduced to measure the degree of modularization...

  2. Comparison of single and modular ANN based fault detector and ...

    African Journals Online (AJOL)

    Effects of variations in pre-fault power flow angle, fault inception angle, source strength, fault resistance, fault type, fault distance and CT saturation have been investigated extensively on the performance of the ANN based protection scheme. Additionally, the effects of network changes: double circuit and single circuit ...

  3. Development of an Efficient Steel Beam Section for Modular Construction Based on Six-Sigma

    Directory of Open Access Journals (Sweden)

    Tae-Hyu Ha

    2016-01-01

    Full Text Available This study presents a systematic approach for the development of an efficient steel beam section for modular construction based on Six-Sigma. Although the Six-Sigma is frequently implemented in manufacturing and other service industries, it is a relatively new concept in the area of building design and construction. As a first step in this approach, market studies and surveys are conducted to obtain the opinions of potential customers. Then the opinions of customers are converted into quality characteristics for the steel beam using the quality function deployment methodology. A steel hollow flanged channel is chosen as the main modular beam shape, and the design concept is derived and developed by applying the Pugh matrix methodology. A pilot test was performed to validate the effectiveness of the developed beam section. The results indicated that the developed channel beam section showed excellent performance and retained high accuracy in fabrication, thus resulting in a significant reduction of steel consumption.

  4. An Educational Kit Based On a Modular Silicon Photomultiplier System

    International Nuclear Information System (INIS)

    Caccia, Massimo; Chmill, Valery; Ebolese, Amedeo; Martemyanov, Alexander; Risigo, Fabio; Santoro, Romualdo; Locatelli, Marco; Pieracci, Maura; Tintori, Carlo

    2013-06-01

    Silicon Photo-Multipliers (SiPM) are state of the art light detectors with unprecedented single photon sensitivity and photon number resolving capability, representing a breakthrough in several fundamental and applied Science domains. An educational experiment based on a SiPM set-up is proposed in this article, guiding the student towards a comprehensive knowledge of this sensor technology while experiencing the quantum nature of light and exploring the statistical properties of the light pulses emitted by a LED. (authors)

  5. Activity Based Costing as a method for assessing the economics of modularization - a case study and beyond

    DEFF Research Database (Denmark)

    Thyssen, Peter; Israelsen, Poul; Jørgensen, Brian

    The paper accounts for an Activity Based Costing (ABC) analysis supporting decision-making concerning product modularity. The ABC analysis carried out is communicated to decision-makers by telling how much higher the variable cost of the multi-purpose module can be compared to the average variable...... cost for the product-unique modules that it substitutes to break even in total cost. The analysis provides the platform for stating three general rules of cost efficiency of modularization, which in combination identify the highest profit potential of product modularisation. Finally the analysis points...... to problems of using ABC in costing modularity, i.e. handling of R&D costs and identification of product-profitability upon an enhanced modularization....

  6. Tile-Based Two-Dimensional Phase Unwrapping for Digital Holography Using a Modular Framework.

    Directory of Open Access Journals (Sweden)

    Georgios C Antonopoulos

    Full Text Available A variety of physical and biomedical imaging techniques, such as digital holography, interferometric synthetic aperture radar (InSAR, or magnetic resonance imaging (MRI enable measurement of the phase of a physical quantity additionally to its amplitude. However, the phase can commonly only be measured modulo 2π, as a so called wrapped phase map. Phase unwrapping is the process of obtaining the underlying physical phase map from the wrapped phase. Tile-based phase unwrapping algorithms operate by first tessellating the phase map, then unwrapping individual tiles, and finally merging them to a continuous phase map. They can be implemented computationally efficiently and are robust to noise. However, they are prone to failure in the presence of phase residues or erroneous unwraps of single tiles. We tried to overcome these shortcomings by creating novel tile unwrapping and merging algorithms as well as creating a framework that allows to combine them in modular fashion. To increase the robustness of the tile unwrapping step, we implemented a model-based algorithm that makes efficient use of linear algebra to unwrap individual tiles. Furthermore, we adapted an established pixel-based unwrapping algorithm to create a quality guided tile merger. These original algorithms as well as previously existing ones were implemented in a modular phase unwrapping C++ framework. By examining different combinations of unwrapping and merging algorithms we compared our method to existing approaches. We could show that the appropriate choice of unwrapping and merging algorithms can significantly improve the unwrapped result in the presence of phase residues and noise. Beyond that, our modular framework allows for efficient design and test of new tile-based phase unwrapping algorithms. The software developed in this study is freely available.

  7. Tile-Based Two-Dimensional Phase Unwrapping for Digital Holography Using a Modular Framework

    Science.gov (United States)

    Antonopoulos, Georgios C.; Steltner, Benjamin; Heisterkamp, Alexander; Ripken, Tammo; Meyer, Heiko

    2015-01-01

    A variety of physical and biomedical imaging techniques, such as digital holography, interferometric synthetic aperture radar (InSAR), or magnetic resonance imaging (MRI) enable measurement of the phase of a physical quantity additionally to its amplitude. However, the phase can commonly only be measured modulo 2π, as a so called wrapped phase map. Phase unwrapping is the process of obtaining the underlying physical phase map from the wrapped phase. Tile-based phase unwrapping algorithms operate by first tessellating the phase map, then unwrapping individual tiles, and finally merging them to a continuous phase map. They can be implemented computationally efficiently and are robust to noise. However, they are prone to failure in the presence of phase residues or erroneous unwraps of single tiles. We tried to overcome these shortcomings by creating novel tile unwrapping and merging algorithms as well as creating a framework that allows to combine them in modular fashion. To increase the robustness of the tile unwrapping step, we implemented a model-based algorithm that makes efficient use of linear algebra to unwrap individual tiles. Furthermore, we adapted an established pixel-based unwrapping algorithm to create a quality guided tile merger. These original algorithms as well as previously existing ones were implemented in a modular phase unwrapping C++ framework. By examining different combinations of unwrapping and merging algorithms we compared our method to existing approaches. We could show that the appropriate choice of unwrapping and merging algorithms can significantly improve the unwrapped result in the presence of phase residues and noise. Beyond that, our modular framework allows for efficient design and test of new tile-based phase unwrapping algorithms. The software developed in this study is freely available. PMID:26599984

  8. Fuzzy OLAP association rules mining-based modular reinforcement learning approach for multiagent systems.

    Science.gov (United States)

    Kaya, Mehmet; Alhajj, Reda

    2005-04-01

    Multiagent systems and data mining have recently attracted considerable attention in the field of computing. Reinforcement learning is the most commonly used learning process for multiagent systems. However, it still has some drawbacks, including modeling other learning agents present in the domain as part of the state of the environment, and some states are experienced much less than others, or some state-action pairs are never visited during the learning phase. Further, before completing the learning process, an agent cannot exhibit a certain behavior in some states that may be experienced sufficiently. In this study, we propose a novel multiagent learning approach to handle these problems. Our approach is based on utilizing the mining process for modular cooperative learning systems. It incorporates fuzziness and online analytical processing (OLAP) based mining to effectively process the information reported by agents. First, we describe a fuzzy data cube OLAP architecture which facilitates effective storage and processing of the state information reported by agents. This way, the action of the other agent, not even in the visual environment. of the agent under consideration, can simply be predicted by extracting online association rules, a well-known data mining technique, from the constructed data cube. Second, we present a new action selection model, which is also based on association rules mining. Finally, we generalize not sufficiently experienced states, by mining multilevel association rules from the proposed fuzzy data cube. Experimental results obtained on two different versions of a well-known pursuit domain show the robustness and effectiveness of the proposed fuzzy OLAP mining based modular learning approach. Finally, we tested the scalability of the approach presented in this paper and compared it with our previous work on modular-fuzzy Q-learning and ordinary Q-learning.

  9. Tile-Based Two-Dimensional Phase Unwrapping for Digital Holography Using a Modular Framework.

    Science.gov (United States)

    Antonopoulos, Georgios C; Steltner, Benjamin; Heisterkamp, Alexander; Ripken, Tammo; Meyer, Heiko

    2015-01-01

    A variety of physical and biomedical imaging techniques, such as digital holography, interferometric synthetic aperture radar (InSAR), or magnetic resonance imaging (MRI) enable measurement of the phase of a physical quantity additionally to its amplitude. However, the phase can commonly only be measured modulo 2π, as a so called wrapped phase map. Phase unwrapping is the process of obtaining the underlying physical phase map from the wrapped phase. Tile-based phase unwrapping algorithms operate by first tessellating the phase map, then unwrapping individual tiles, and finally merging them to a continuous phase map. They can be implemented computationally efficiently and are robust to noise. However, they are prone to failure in the presence of phase residues or erroneous unwraps of single tiles. We tried to overcome these shortcomings by creating novel tile unwrapping and merging algorithms as well as creating a framework that allows to combine them in modular fashion. To increase the robustness of the tile unwrapping step, we implemented a model-based algorithm that makes efficient use of linear algebra to unwrap individual tiles. Furthermore, we adapted an established pixel-based unwrapping algorithm to create a quality guided tile merger. These original algorithms as well as previously existing ones were implemented in a modular phase unwrapping C++ framework. By examining different combinations of unwrapping and merging algorithms we compared our method to existing approaches. We could show that the appropriate choice of unwrapping and merging algorithms can significantly improve the unwrapped result in the presence of phase residues and noise. Beyond that, our modular framework allows for efficient design and test of new tile-based phase unwrapping algorithms. The software developed in this study is freely available.

  10. Instrumentino: An open-source modular Python framework for controlling Arduino based experimental instruments

    Science.gov (United States)

    Koenka, Israel Joel; Sáiz, Jorge; Hauser, Peter C.

    2014-10-01

    Instrumentino is an open-source modular graphical user interface framework for controlling Arduino based experimental instruments. It expands the control capability of Arduino by allowing instruments builders to easily create a custom user interface program running on an attached personal computer. It enables the definition of operation sequences and their automated running without user intervention. Acquired experimental data and a usage log are automatically saved on the computer for further processing. The use of the programming language Python also allows easy extension. Complex devices, which are difficult to control using an Arduino, may be integrated as well by incorporating third party application programming interfaces into the Instrumentino framework.

  11. Modular Hybrid Energy Concept Employing a Novel Control Structure Based on a Simple Analog System

    Directory of Open Access Journals (Sweden)

    PETREUS, D.

    2016-05-01

    Full Text Available This paper proposes a novel control topology which enables the setup of a low cost analog system leading to the implementation of a modular energy conversion system. The modular concept is based on hybrid renewable energy (solar and wind and uses high voltage inverters already available on the market. An important feature of the proposed topology is a permanently active current loop, which assures short circuit protection and simplifies the control loops compensation. The innovative analogue solution of the control structure is based on a dedicated integrated circuit (IC for power factor correction (PFC circuits, used in a new configuration, to assure an efficient inverter start-up. The energy conversion system (control structure and maximum power point tracking algorithm is simulated using a new macromodel-based concept, which reduces the usual computational burden of the simulator and achieves high processing speed. The proposed novel system is presented in this article from concept, through the design and implementation stages, is verified through simulation and is validated by experimental results.

  12. Equipment concept design and development plans for microgravity science and applications research on space station: Combustion tunnel, laser diagnostic system, advanced modular furnace, integrated electronics laboratory

    Science.gov (United States)

    Uhran, M. L.; Youngblood, W. W.; Georgekutty, T.; Fiske, M. R.; Wear, W. O.

    1986-01-01

    Taking advantage of the microgravity environment of space NASA has initiated the preliminary design of a permanently manned space station that will support technological advances in process science and stimulate the development of new and improved materials having applications across the commercial spectrum. Previous studies have been performed to define from the researcher's perspective, the requirements for laboratory equipment to accommodate microgravity experiments on the space station. Functional requirements for the identified experimental apparatus and support equipment were determined. From these hardware requirements, several items were selected for concept designs and subsequent formulation of development plans. This report documents the concept designs and development plans for two items of experiment apparatus - the Combustion Tunnel and the Advanced Modular Furnace, and two items of support equipment the Laser Diagnostic System and the Integrated Electronics Laboratory. For each concept design, key technology developments were identified that are required to enable or enhance the development of the respective hardware.

  13. Knowledge-based modularization and global optimization of artificial neural network models in hydrological forecasting.

    Science.gov (United States)

    Corzo, Gerald; Solomatine, Dimitri

    2007-05-01

    Natural phenomena are multistationary and are composed of a number of interacting processes, so one single model handling all processes often suffers from inaccuracies. A solution is to partition data in relation to such processes using the available domain knowledge or expert judgment, to train separate models for each of the processes, and to merge them in a modular model (committee). In this paper a problem of water flow forecast in watershed hydrology is considered where the flow process can be presented as consisting of two subprocesses -- base flow and excess flow, so that these two processes can be separated. Several approaches to data separation techniques are studied. Two case studies with different forecast horizons are considered. Parameters of the algorithms responsible for data partitioning are optimized using genetic algorithms and global pattern search. It was found that modularization of ANN models using domain knowledge makes models more accurate, if compared with a global model trained on the whole data set, especially when forecast horizon (and hence the complexity of the modelled processes) is increased.

  14. Building a Network Based Laboratory Environment

    Directory of Open Access Journals (Sweden)

    Sea Shuan Luo

    2009-12-01

    Full Text Available This paper presents a comparative study about the development of a network based laboratory environment in the “Unix introduction” course for the undergraduate students. The study results and the response from the students from 2005 to 2006 will be used to better understand what kind of method is more suitable for students. We also use the data collected to adjust our teaching strategy and try to build up a network based laboratory environment.

  15. Cost-based optimizations of power density and target-blanket modularity for 232Th/233U-based ADEP

    International Nuclear Information System (INIS)

    Krakowski, R.A.

    1995-01-01

    A cost-based parametric systems model is developed for an Accelerator-Driven Energy Production (ADEP) system based on a 232 Th/ 233 U fuel cycle and a molten-salt (LiF/BeF 2 /ThF 3 ) fluid-fuel primary system. Simplified neutron-balance, accelerator, reactor-core, chemical-processing, and balance-of-plant models are combined parametrically with a simplified costing model. The main focus of this model is to examine trade offs related to fission power density, reactor-core modularity, 233 U breeding rate, and fission product transmutation capacity

  16. A Distributed Control Strategy Based on DC Bus Signaling for Modular Photovoltaic Generation Systems With Battery Energy Storage

    DEFF Research Database (Denmark)

    Sun, Kai; Zhang, Li; Xing, Yan

    2011-01-01

    Modular generation system, which consists of modular power conditioning converters, is an effective solution to integrate renewable energy sources with conventional utility grid to improve reliability and efficiency, especially for photovoltaic generation. A distributed control strategy based...... charging/discharging and local loads, which is available of either grid-connected operation or islanding operation. By using the proposed control strategy, the operations of a modular PV generation system are categorized into four modes: islanding with battery discharging, grid-connected rectification......, grid-connected inversion, and islanding with constant voltage (CV) generation.The power balance of the system under extreme conditions such as the islanding operation with a full-charged battery is taken into account in this control strategy. The dc bus voltage level is employed as an information...

  17. Effects of modularity in financial markets on an agent-based model

    Science.gov (United States)

    Kim, Hongseok; Kim, Seunghwan; Oh, Gabjin

    2012-02-01

    We investigate an agent-based model of financial markets that is made up of numerous interacting agents with respect to local and global coupling and intrinsic randomness. The prices or return time series are constructed by using the essential mechanism of non-trivial interactions between agents. The characteristics that can describe a financial time series are the fat-tail distribution in the return time series and the long-term memory and clustering behavior in the volatility data. We find that for the proper parameter values, the probability distribution function of the return time series follows a power-law distribution with various scaling exponents that vary with the control parameter set. In particular, the local coupling strength considered as the modularity in financial markets plays an important role in terms of price formation.

  18. A modular diagnosis system based on fuzzy logic for UASB reactors treating sewage.

    Science.gov (United States)

    Borges, R M; Mattedi, A; Munaro, C J; Franci Gonçalves, R

    A modular diagnosis system (MDS), based on the framework of fuzzy logic, is proposed for upflow anaerobic sludge blanket (UASB) reactors treating sewage. In module 1, turbidity and rainfall information are used to estimate the influent organic content. In module 2, a dynamic fuzzy model is used to estimate the current biogas production from on-line measured variables, such as daily average temperature and the previous biogas flow rate, as well as the organic load. Finally, in module 3, all the information above and the residual value between the measured and estimated biogas production are used to provide diagnostic information about the operation status of the plant. The MDS was validated through its application to two pilot UASB reactors and the results showed that the tool can provide useful diagnoses to avoid plant failures.

  19. Service Modularity

    DEFF Research Database (Denmark)

    Avlonitis, Viktor; Hsuan, Juliana

    2015-01-01

    The purpose of this research is to investigate the studies on service modularity with a goal of informing service science and advancing contemporary service systems research. Modularity, a general systems property, can add theoretical underpinnings to the conceptual development of service science...... in general and service systems in particular. Our research is guided by the following question: how can modularity theory inform service system design? We present a review of the modularity literature and associated concepts. We then introduce the contemporary service science and service system discourse...

  20. Service Modularity

    DEFF Research Database (Denmark)

    Avlonitis, Viktor; Hsuan, Juliana

    2015-01-01

    in general and service systems in particular. Our research is guided by the following question: how can modularity theory inform service system design? We present a review of the modularity literature and associated concepts. We then introduce the contemporary service science and service system discourse......The purpose of this research is to investigate the studies on service modularity with a goal of informing service science and advancing contemporary service systems research. Modularity, a general systems property, can add theoretical underpinnings to the conceptual development of service science...

  1. Theoretical Interpretation of Modular Artistic Forms Based on the Example of Contemporarylithuanian Architecture

    Directory of Open Access Journals (Sweden)

    Aušra Černauskienė

    2015-05-01

    Full Text Available The article analyses modular artistic forms that emerge in all scale structures of contemporary architecture. Module, as a standard unit of measure has been in use since antiquity. It gained even more significance amid innovative building and computing technologies of the 20th and 21st centuries. Static and fixed perceptions of a module were supplemented with concepts of dynamic and adaptable modular units, such as fractals, parameters and algorithms. Various expressions and trends of modular design appear in contemporary architecture of Lithuania, where modular forms consist of repetitive spatial and planar elements. Spatial modules as blocks or flats and planar modular wall elements are a characteristic expression of the contemporary architecture in Lithuania.

  2. Performance of Modular Prefabricated Architecture: Case Study-Based Review and Future Pathways

    Directory of Open Access Journals (Sweden)

    Fred Edmond Boafo

    2016-06-01

    Full Text Available Even though tightened building energy efficiency standards are implemented periodically in many countries, existing buildings continually consume a momentous quota of the total primary energy. Energy efficiency solutions range from material components to bulk systems. A technique of building construction, referred to as prefabricated architecture (prefab, is increasing in reputation. Prefab encompasses the offsite fabrication of building components to a greater degree of finish as bulk building structures and systems, and their assembly on-site. In this context, prefab improves the speed of construction, quality of architecture, efficiency of materials, and worker safety, while limiting environmental impacts of construction, as compared to conventional site-built construction practices. Quite recently, a 57 story skyscraper was built in 19 days using prefabricated modules. From the building physics point of view, the bulk systems and tighter integration method of prefab minimizes thermal bridges. This study seeks to clearly characterize the levels of prefab and to investigate the performance of modular prefab; considering acoustic constrain, seismic resistance, thermal behavior, energy consumption, and life cycle analysis of existing prefab cases and, thus, provides a dynamic case study-based review. Generally, prefab can be categorized into components, panels (2D, modules (3D, hybrids, and unitized whole buildings. On average, greenhouse gas emissions from conventional construction were higher than for modular construction, not discounting some individual discrepancies. Few studies have focused on monitored data on prefab and occupants’ comfort but additional studies are required to understand the public’s perception of the technology. The scope of the work examined will be of interest to building engineers, manufacturers, and energy experts, as well as serve as a foundational reference for future study.

  3. Modularizing development

    DEFF Research Database (Denmark)

    Müller, Anders Riel; Doucette, Jamie

    In 2007, South Korea's Ministry of Strategy and Finance (MOSF) and the Korea Development Institute (KDI) launched the Knowledge Sharing Program (KSP) to satisfy the growing interest in Korea's rapid development from high growth economies in East Asia and Africa. The KSP's mandate is "to offer...... a deeper and wider understanding of Korea’s development experience with the hope that Korea’s past can offer lessons for developing countries in search of sustainable and broad‐based development" (KSP 2011). To do so, the KSP provides users with a modularized set of policy narratives that represent Korea...... as a unique success story of sustainable and equitable development worth emulating. These narratives accord South Korea considerable international status and portray it as a country with recent, hands‐on development expertise that is directly relevant to the needs of developing economies. Furthermore...

  4. A modular control system

    International Nuclear Information System (INIS)

    Cruz, B.; Drexler, J.; Olcese, G.; Santome, D.

    1990-01-01

    The main objective of the modular control system is to provide the requirements to most of the processes supervision and control applications within the industrial automatization area. The design is based on distribution, modulation and expansion concepts. (Author) [es

  5. Modular forms

    NARCIS (Netherlands)

    Edixhoven, B.; van der Geer, G.; Moonen, B.; Edixhoven, B.; van der Geer, G.; Moonen, B.

    2008-01-01

    Modular forms are functions with an enormous amount of symmetry that play a central role in number theory, connecting it with analysis and geometry. They have played a prominent role in mathematics since the 19th century and their study continues to flourish today. Modular forms formed the

  6. Development of Integrated Modular Avionics Application Based on Simulink and XtratuM

    Science.gov (United States)

    Fons-Albert, Borja; Usach-Molina, Hector; Vila-Carbo, Joan; Crespo-Lorente, Alfons

    2013-08-01

    This paper presents an integral approach for designing avionics applications that meets the requirements for software development and execution of this application domain. Software design follows the Model-Based design process and is performed in Simulink. This approach allows easy and quick testbench development and helps satisfying DO-178B requirements through the use of proper tools. The software execution platform is based on XtratuM, a minimal bare-metal hypervisor designed in our research group. XtratuM provides support for IMA-SP (Integrated Modular Avionics for Space) architectures. This approach allows the code generation of a Simulink model to be executed on top of Lithos as XtratuM partition. Lithos is a ARINC-653 compliant RTOS for XtratuM. The paper concentrates in how to smoothly port Simulink designs to XtratuM solving problems like application partitioning, automatic code generation, real-time tasking, interfacing, and others. This process is illustrated with an autopilot design test using a flight simulator.

  7. Modular extracellular sensor architecture for engineering mammalian cell-based devices.

    Science.gov (United States)

    Daringer, Nichole M; Dudek, Rachel M; Schwarz, Kelly A; Leonard, Joshua N

    2014-12-19

    Engineering mammalian cell-based devices that monitor and therapeutically modulate human physiology is a promising and emerging frontier in clinical synthetic biology. However, realizing this vision will require new technologies enabling engineered circuitry to sense and respond to physiologically relevant cues. No existing technology enables an engineered cell to sense exclusively extracellular ligands, including proteins and pathogens, without relying upon native cellular receptors or signal transduction pathways that may be subject to crosstalk with native cellular components. To address this need, we here report a technology we term a Modular Extracellular Sensor Architecture (MESA). This self-contained receptor and signal transduction platform is maximally orthogonal to native cellular processes and comprises independent, tunable protein modules that enable performance optimization and straightforward engineering of novel MESA that recognize novel ligands. We demonstrate ligand-inducible activation of MESA signaling, optimization of receptor performance using design-based approaches, and generation of MESA biosensors that produce outputs in the form of either transcriptional regulation or transcription-independent reconstitution of enzymatic activity. This systematic, quantitative platform characterization provides a framework for engineering MESA to recognize novel ligands and for integrating these sensors into diverse mammalian synthetic biology applications.

  8. A Novel Clustering Methodology Based on Modularity Optimisation for Detecting Authorship Affinities in Shakespearean Era Plays.

    Directory of Open Access Journals (Sweden)

    Leila M Naeni

    Full Text Available In this study we propose a novel, unsupervised clustering methodology for analyzing large datasets. This new, efficient methodology converts the general clustering problem into the community detection problem in graph by using the Jensen-Shannon distance, a dissimilarity measure originating in Information Theory. Moreover, we use graph theoretic concepts for the generation and analysis of proximity graphs. Our methodology is based on a newly proposed memetic algorithm (iMA-Net for discovering clusters of data elements by maximizing the modularity function in proximity graphs of literary works. To test the effectiveness of this general methodology, we apply it to a text corpus dataset, which contains frequencies of approximately 55,114 unique words across all 168 written in the Shakespearean era (16th and 17th centuries, to analyze and detect clusters of similar plays. Experimental results and comparison with state-of-the-art clustering methods demonstrate the remarkable performance of our new method for identifying high quality clusters which reflect the commonalities in the literary style of the plays.

  9. Ground-based studies of tropisms in hardware developed for the European Modular Cultivation System (EMCS)

    Science.gov (United States)

    Correll, Melanie J.; Edelmann, Richard E.; Hangarter, Roger P.; Mullen, Jack L.; Kiss, John Z.

    Phototropism and gravitropism play key roles in the oriented growth of roots in flowering plants. In blue or white light, roots exhibit negative phototropism, but red light induces positive phototropism in Arabidopsis roots. The blue-light response is controlled by the phototropins while the red-light response is mediated by the phytochrome family of photoreceptors. In order to better characterize root phototropism, we plan to perform experiments in microgravity so that this tropism can be more effectively studied without the interactions with the gravity response. Our experiments are to be performed on the European Modular Cultivation System (EMCS), which provides an incubator, lighting system, and high resolution video that are on a centrifuge palette. These experiments will be performed at μg, 1g (control) and fractional g-levels. In order to ensure success of this mission on the International Space Station, we have been conducting ground-based studies on growth, phototropism, and gravitropism in experimental unique equipment (EUE) that was designed for our experiments with Arabidopsis seedlings. Currently, the EMCS and our EUE are scheduled for launch on space shuttle mission STS-121. This project should provide insight into how the blue- and red-light signaling systems interact with each other and with the gravisensing system.

  10. A starfish robot based on soft and smart modular structure (SMS) actuated by SMA wires.

    Science.gov (United States)

    Jin, Hu; Dong, Erbao; Alici, Gursel; Mao, Shixin; Min, Xu; Liu, Chunshan; Low, K H; Yang, Jie

    2016-09-09

    This paper describes the design, fabrication and locomotion of a starfish robot whose locomotion principle is derived from a starfish. The starfish robot has a number of tentacles or arms extending from its central body in the form of a disk, like the topology of a real starfish. The arm, which is a soft and composite structure (which we call the smart modular structure (SMS)) generating a planar reciprocal motion with a high speed of response upon the actuation provided by the shape memory alloy (SMA) wires, is fabricated from soft and smart materials. Based on the variation in the resistance of the SMA wires during their heating, an adaptive regulation (AR) heating strategy is proposed to (i) avoid overheating of the SMA wires, (ii) provide bending range control and (iii) achieve a high speed of response favorable to successfully propelling the starfish robot. Using a finite-segment method, a thermal dynamic model of the SMS is established to describe its thermal behavior under the AR and a constant heating strategy. A starfish robot with five SMS tentacles was tested with different control parameters to optimize its locomotion speed. As demonstrated in the accompanying video file, the robot successfully propelled in semi-submerged and underwater environments show its locomotion ability in the multi-media, like a real starfish. The propulsion speed of the starfish robot is at least an order of magnitude higher than that of those reported in the literature-thanks to the SMS controlled with the AR strategy.

  11. Modular Approach to Launch Vehicle Design Based on a Common Core Element

    Science.gov (United States)

    Creech, Dennis M.; Threet, Grady E., Jr.; Philips, Alan D.; Waters, Eric D.; Baysinger, Mike

    2010-01-01

    With a heavy lift launch vehicle as the centerpiece of our nation's next exploration architecture's infrastructure, the Advanced Concepts Office at NASA's Marshall Space Flight Center initiated a study to examine the utilization of elements derived from a heavy lift launch vehicle for other potential launch vehicle applications. The premise of this study is to take a vehicle concept, which has been optimized for Lunar Exploration, and utilize the core stage with other existing or near existing stages and boosters to determine lift capabilities for alternative missions. This approach not only yields a vehicle matrix with a wide array of capabilities, but also produces an evolutionary pathway to a vehicle family based on a minimum development and production cost approach to a launch vehicle system architecture, instead of a purely performance driven approach. The upper stages and solid rocket booster selected for this study were chosen to reflect a cross-section of: modified existing assets in the form of a modified Delta IV upper stage and Castor-type boosters; potential near term launch vehicle component designs including an Ares I upper stage and 5-segment boosters; and longer lead vehicle components such as a Shuttle External Tank diameter upper stage. The results of this approach to a modular launch system are given in this paper.

  12. Craniux: A LabVIEW-Based Modular Software Framework for Brain-Machine Interface Research

    Directory of Open Access Journals (Sweden)

    Alan D. Degenhart

    2011-01-01

    Full Text Available This paper presents “Craniux,” an open-access, open-source software framework for brain-machine interface (BMI research. Developed in LabVIEW, a high-level graphical programming environment, Craniux offers both out-of-the-box functionality and a modular BMI software framework that is easily extendable. Specifically, it allows researchers to take advantage of multiple features inherent to the LabVIEW environment for on-the-fly data visualization, parallel processing, multithreading, and data saving. This paper introduces the basic features and system architecture of Craniux and describes the validation of the system under real-time BMI operation using simulated and real electrocorticographic (ECoG signals. Our results indicate that Craniux is able to operate consistently in real time, enabling a seamless work flow to achieve brain control of cursor movement. The Craniux software framework is made available to the scientific research community to provide a LabVIEW-based BMI software platform for future BMI research and development.

  13. 3D printed Lego®-like modular microfluidic devices based on capillary driving.

    Science.gov (United States)

    Nie, Jing; Gao, Qing; Qiu, Jing-Jiang; Sun, Miao; Liu, An; Shao, Lei; Fu, Jian-Zhong; Zhao, Peng; He, Yong

    2018-03-12

    The field of how to rapidly assemble microfluidics with modular components continuously attracts researchers' attention, however, extra efforts must be devoted to solving the problems of leaking and aligning between individual modules. This paper presents a novel type of modular microfluidic device, driven by capillary force. There is no necessity for a strict seal or special alignment, and its open structures make it easy to integrate various stents and reactants. The key rationale for this method is to print different functional modules with a low-cost three-dimensional (3D) printer, then fill the channels with capillary materials and assemble them with plugs like Lego ® bricks. This rapidly reconstructed modular microfluidic device consists of a variety of common functional modules and other personalized modules, each module having a unified standard interface for easy assembly. As it can be printed by a desktop 3D printer, the manufacturing process is simple and efficient, with controllable regulation of the flow channel scale. Through diverse combinations of different modules, a variety of different functions can be achieved, without duplicating the manufacturing process. A single module can also be taken out for testing and analysis. What's more, combined with basic circuit components, it can serve as a low-cost Lego ® -like modular microfluidic circuits. As a proof of concept, the modular microfluidic device has been successfully demonstrated and used for stent degradation and cell cultures, revealing the potential use of this method in both chemical and biological research.

  14. Protection of Multiterminal HVDC Grids based on Modular Multilevel Converters: DC Fault Ride-Through and AC Grid Support

    OpenAIRE

    Kontos, E.

    2018-01-01

    High Voltage DC (HVDC) grids provide an efficient solution for the transmission of bulk power over long distances between the energy production and consumption centers. Up to now, most of the implemented dc connections are point-to-point, creating dc links to strengthen the existing, predominantly ac, electricity grid. However, to optimize the use of assets and energy harvest, multi-terminal HVdc grids are envisioned. Based on recent research and industrial trends, the Multilevel Modular Conv...

  15. Dualisme Modular

    Directory of Open Access Journals (Sweden)

    Natas Setiabudhi Daryono Putra

    2017-09-01

    and night, body and soul, health and sickness, rich and poor, good and evil, halal and haram, pro and con, active and passive, static and dynamic, good and bad looking, big and small, long and short, bitter and sweet, expensive and cheap, strong and weak, and so on. In the context of art, dualism is the representation of human beings as basically having two personalities, good and evil. Both were translated into a modular concept for creating a work configuration. The message that the artist wanted to deliver is that an individual cannot be judged from the ‘clothes or uniform’ s/he wears. In addition, a balance between good and evil represented by positive and negative modules is ambiguous in relation to the concept of reward and punishment in Islam. This final project draws upon the famous vase/goblet picture by Danish gestalt psychologist Edgar Rubin, which was transformed into a three-dimensional ceramic artwork [1]. Rubin’s vase/goblet perceptually contains two meanings, namely the image of a vase/goblet and a facial silhouette facing each other (alternatingly appearing as object or background. The creative process comes from personal-empirical experience linked to the supporting theory. The combination of both resulted in an artwork that represents reality. Generally, in the creation of visual artworks there is no formal method as in scientific research. The creative process is sometimes based on intuition, a dominant personal experience and contains a very subjective narration. All of these are related to other disciplines (social, economical, cultural and political, in order to create a representation.

  16. Voltage-Balancing Method for Modular Multilevel Converters Under Phase-Shifted Carrier-Based Pulsewidth Modulation

    DEFF Research Database (Denmark)

    Deng, Fujin; Chen, Zhe

    2015-01-01

    The modular multilevel converter (MMC) becomes attractive for medium- or high-power applications because of the advantages of high modularity, availability, and power quality. One of the technical challenges associated with an MMC is the balancing of the capacitors' voltages. In this paper......, a voltage-balancing control method is proposed for the MMC under phase-shifted carrier-based pulsewidth modulation. The proposed voltage-balancing method uses the linearization method for pulse sorting without arm current measurement, which can control the capacitor charge transfer to balance the capacitor....../EMTDC are conducted, and a downscale MMC prototype is also tested with the proposed method. The study results show the effectiveness of the proposed voltage-balancing method....

  17. Modular Multi-level converter based HVDC System for Grid Connection of Offshore Wind Power Plant

    DEFF Research Database (Denmark)

    Gnanarathna, U.N.; Chaudhary, Sanjay Kumar; Gole, A.M.

    2010-01-01

    This paper explores the application of modular multi-level converters (MMC) as a means for harnessing the power from off-shore wind power plants. The MMC consists of a large number of simple voltage sourced converter (VSC) submodules that can be easily assembled into a converter for high-voltage ...

  18. MrTADFinder: A network modularity based approach to identify topologically associating domains in multiple resolutions.

    Directory of Open Access Journals (Sweden)

    Koon-Kiu Yan

    2017-07-01

    Full Text Available Genome-wide proximity ligation based assays such as Hi-C have revealed that eukaryotic genomes are organized into structural units called topologically associating domains (TADs. From a visual examination of the chromosomal contact map, however, it is clear that the organization of the domains is not simple or obvious. Instead, TADs exhibit various length scales and, in many cases, a nested arrangement. Here, by exploiting the resemblance between TADs in a chromosomal contact map and densely connected modules in a network, we formulate TAD identification as a network optimization problem and propose an algorithm, MrTADFinder, to identify TADs from intra-chromosomal contact maps. MrTADFinder is based on the network-science concept of modularity. A key component of it is deriving an appropriate background model for contacts in a random chain, by numerically solving a set of matrix equations. The background model preserves the observed coverage of each genomic bin as well as the distance dependence of the contact frequency for any pair of bins exhibited by the empirical map. Also, by introducing a tunable resolution parameter, MrTADFinder provides a self-consistent approach for identifying TADs at different length scales, hence the acronym "Mr" standing for Multiple Resolutions. We then apply MrTADFinder to various Hi-C datasets. The identified domain boundaries are marked by characteristic signatures in chromatin marks and transcription factors (TF that are consistent with earlier work. Moreover, by calling TADs at different length scales, we observe that boundary signatures change with resolution, with different chromatin features having different characteristic length scales. Furthermore, we report an enrichment of HOT (high-occupancy target regions near TAD boundaries and investigate the role of different TFs in determining boundaries at various resolutions. To further explore the interplay between TADs and epigenetic marks, as tumor mutational

  19. Web-based execution of graphical work-flows: a modular platform for multifunctional scientific process automation

    International Nuclear Information System (INIS)

    De Ley, E.; Jacobs, D.; Ounsy, M.

    2012-01-01

    The Passerelle process automation suite offers a fundamentally modular solution platform, based on a layered integration of several best-of-breed technologies. It has been successfully applied by Synchrotron Soleil as the sequencer for data acquisition and control processes on its beamlines, integrated with TANGO as a control bus and GlobalScreen TM ) as the SCADA package. Since last year it is being used as the graphical work-flow component for the development of an eclipse-based Data Analysis Work Bench, at ESRF. The top layer of Passerelle exposes an actor-based development paradigm, based on the Ptolemy framework (UC Berkeley). Actors provide explicit reusability and strong decoupling, combined with an inherently concurrent execution model. Actor libraries exist for TANGO integration, web-services, database operations, flow control, rules-based analysis, mathematical calculations, launching external scripts etc. Passerelle's internal architecture is based on OSGi, the major Java framework for modular service-based applications. A large set of modules exist that can be recombined as desired to obtain different features and deployment models. Besides desktop versions of the Passerelle work-flow workbench, there is also the Passerelle Manager. It is a secured web application including a graphical editor, for centralized design, execution, management and monitoring of process flows, integrating standard Java Enterprise services with OSGi. We will present the internal technical architecture, some interesting application cases and the lessons learnt. (authors)

  20. Modular Engineering of Production Plants

    DEFF Research Database (Denmark)

    Miller, Thomas Dedenroth

    1998-01-01

    Based on a case-study on design of pharmaceutical production plants, this paper suggests that modularity may support business efficiency for companies with one-of-a-kind production and without in-house manufacturing. Modularity may support efficient management of design knowledge and may facilitate...

  1. A mathematical formulation for interface-based modular product design with geometric and weight constraints

    Science.gov (United States)

    Jung-Woon Yoo, John

    2016-06-01

    Since customer preferences change rapidly, there is a need for design processes with shorter product development cycles. Modularization plays a key role in achieving mass customization, which is crucial in today's competitive global market environments. Standardized interfaces among modularized parts have facilitated computational product design. To incorporate product size and weight constraints during computational design procedures, a mixed integer programming formulation is presented in this article. Product size and weight are two of the most important design parameters, as evidenced by recent smart-phone products. This article focuses on the integration of geometric, weight and interface constraints into the proposed mathematical formulation. The formulation generates the optimal selection of components for a target product, which satisfies geometric, weight and interface constraints. The formulation is verified through a case study and experiments are performed to demonstrate the performance of the formulation.

  2. Collaborative Assembly Operation between Two Modular Robots Based on the Optical Position Feedback

    Directory of Open Access Journals (Sweden)

    Liying Su

    2009-01-01

    Full Text Available This paper studies the cooperation between two master-slave modular robots. A cooperative robot system is set up with two modular robots and a dynamic optical meter-Optotrak. With Optotrak, the positions of the end effectors are measured as the optical position feedback, which is used to adjust the robots' end positions. A tri-layered motion controller is designed for the two cooperative robots. The RMRC control method is adopted to adjust the master robot to the desired position. With the kinematics constraints of the two robots including position and pose, joint velocity, and acceleration constraints, the two robots can cooperate well. A bolt and nut assembly experiment is executed to verify the methods.

  3. Microprocessor- and LSI-based CAMAC RAM controllers in a modular multiparameter instrumentation system

    International Nuclear Information System (INIS)

    Skarda, V.

    1982-01-01

    This contribution deals with the main features and with the hardware modifications of RAM controllers in the dual-port accessed CAMAC memory modules that have been applied in a modular multichannel analyzer instrumentation system. The modules described in this paper are fully compatible with the CAMAC standard EUR 4100 and with the COMPEX draft proposal of the ESONE Study Group, as well. Special attention is paid to the possible application of modern LSI bipolar circuits. (orig.)

  4. Label-based routing for a family of scale-free, modular, planar and unclustered graphs

    International Nuclear Information System (INIS)

    Comellas, Francesc; Miralles, Alicia

    2011-01-01

    We give an optimal labeling and routing algorithm for a family of scale-free, modular and planar graphs with zero clustering. The relevant properties of this family match those of some networks associated with technological and biological systems with a low clustering, including some electronic circuits and protein networks. The existence of an efficient routing protocol for this graph model should help when designing communication algorithms in real networks and also in the understanding of their dynamic processes.

  5. Product modular design incorporating preventive maintenance issues

    Science.gov (United States)

    Gao, Yicong; Feng, Yixiong; Tan, Jianrong

    2016-03-01

    Traditional modular design methods lead to product maintenance problems, because the module form of a system is created according to either the function requirements or the manufacturing considerations. For solving these problems, a new modular design method is proposed with the considerations of not only the traditional function related attributes, but also the maintenance related ones. First, modularity parameters and modularity scenarios for product modularity are defined. Then the reliability and economic assessment models of product modularity strategies are formulated with the introduction of the effective working age of modules. A mathematical model used to evaluate the difference among the modules of the product so that the optimal module of the product can be established. After that, a multi-objective optimization problem based on metrics for preventive maintenance interval different degrees and preventive maintenance economics is formulated for modular optimization. Multi-objective GA is utilized to rapidly approximate the Pareto set of optimal modularity strategy trade-offs between preventive maintenance cost and preventive maintenance interval difference degree. Finally, a coordinate CNC boring machine is adopted to depict the process of product modularity. In addition, two factorial design experiments based on the modularity parameters are constructed and analyzed. These experiments investigate the impacts of these parameters on the optimal modularity strategies and the structure of module. The research proposes a new modular design method, which may help to improve the maintainability of product in modular design.

  6. Building an Agent-Based Laboratory Infrastructure for Higher Education

    Directory of Open Access Journals (Sweden)

    Muna Saqer

    2009-08-01

    Full Text Available We present an ongoing project at the University of Houston- Downtown (UHD that aims to build a grid as a laboratory environment to support undergraduate education. We intend to use this PC clusters centered grid to allow students to perform laboratory exercises through web interfaces. In order to accommodate lab packages of a growing number of courses, we design the system as a modular system using multi-agent modeling. Students are recruited to implement the units of the system as senior student project topics or research activities sponsored by the Scholar's Academy of UHD. Through these projects, we geared our research toward higher education and provided students with opportunities to participate in building a computational infrastructure for curriculum improvement. This is very important for a minority-serving institution (MSI with limited resources such as UHD.

  7. Known structure, unknown function: An inquiry‐based undergraduate biochemistry laboratory course

    Science.gov (United States)

    Gray, Cynthia; Price, Carol W.; Lee, Christopher T.; Dewald, Alison H.; Cline, Matthew A.; McAnany, Charles E.

    2015-01-01

    Abstract Undergraduate biochemistry laboratory courses often do not provide students with an authentic research experience, particularly when the express purpose of the laboratory is purely instructional. However, an instructional laboratory course that is inquiry‐ and research‐based could simultaneously impart scientific knowledge and foster a student's research expertise and confidence. We have developed a year‐long undergraduate biochemistry laboratory curriculum wherein students determine, via experiment and computation, the function of a protein of known three‐dimensional structure. The first half of the course is inquiry‐based and modular in design; students learn general biochemical techniques while gaining preparation for research experiments in the second semester. Having learned standard biochemical methods in the first semester, students independently pursue their own (original) research projects in the second semester. This new curriculum has yielded an improvement in student performance and confidence as assessed by various metrics. To disseminate teaching resources to students and instructors alike, a freely accessible Biochemistry Laboratory Education resource is available at http://biochemlab.org. © 2015 The Authors Biochemistry and Molecular Biology Education published by Wiley Periodicals, Inc. on behalf of International Union of Biochemistry and Molecular Biology, 43(4):245–262, 2015. PMID:26148241

  8. Systems dynamics (SD) strategy for Small Modular Reactor (SMR) marketing - Conquest at the MIT Energy Laboratory (Pres. MIT Energy Initiative)

    International Nuclear Information System (INIS)

    Woo, T. H.

    2016-01-01

    This reactor has the specification as the power is 330 MWt pressurized water reactor (PWR) with integral steam generators and advanced safety features. In the plant design, it is planned for electricity generation of 100 MWe and thermal applications of seawater desalination where the life span is a 60-year operation design and three-year refueling cycle. Regarding of the licensing, the standard design was approved from the Korean regulator in mid-2012 and the Korea Atomic Energy Research Institute (KAERI) has a plan to build a demonstration plant to operate from 2017. According to the previous study of the marketing strategy of the Canadian small reactor, Safe LOW-POwer Kritical Experiment (SLOWPOKE) reactor had been investigated in 1988. Therefore, it is interesting to compare SMART and SLOWPOKE. In this work, it is to find out the strategy of the successful marketing of SMART and suggest continuous marketing prospects. There are specifications and parameters of SMART in Tables 1 and 2. The public acceptance (PA) had been studies as safety-public interpretation, SLOWPOKE safety-experience and process, and economics in the previous paper of the SLOWPOKE, which was about the marketing strategy for the commercial nuclear reactor. The highly cognitive networking based dynamical modeling was discussed where the system is treated by a complex and non-linear way. The linear networking of the interested issue was changed by the SD algorithm where the feedback and multiple connections are added to the original networking theory. The non-linear method has shown the complexity of the marketing strategy, especially for the NPP which is the very expensive and safety focused facility

  9. Systems dynamics (SD) strategy for Small Modular Reactor (SMR) marketing - Conquest at the MIT Energy Laboratory (Pres. MIT Energy Initiative)

    Energy Technology Data Exchange (ETDEWEB)

    Woo, T. H. [Yonsei University, Wonju (Korea, Republic of)

    2016-10-15

    This reactor has the specification as the power is 330 MWt pressurized water reactor (PWR) with integral steam generators and advanced safety features. In the plant design, it is planned for electricity generation of 100 MWe and thermal applications of seawater desalination where the life span is a 60-year operation design and three-year refueling cycle. Regarding of the licensing, the standard design was approved from the Korean regulator in mid-2012 and the Korea Atomic Energy Research Institute (KAERI) has a plan to build a demonstration plant to operate from 2017. According to the previous study of the marketing strategy of the Canadian small reactor, Safe LOW-POwer Kritical Experiment (SLOWPOKE) reactor had been investigated in 1988. Therefore, it is interesting to compare SMART and SLOWPOKE. In this work, it is to find out the strategy of the successful marketing of SMART and suggest continuous marketing prospects. There are specifications and parameters of SMART in Tables 1 and 2. The public acceptance (PA) had been studies as safety-public interpretation, SLOWPOKE safety-experience and process, and economics in the previous paper of the SLOWPOKE, which was about the marketing strategy for the commercial nuclear reactor. The highly cognitive networking based dynamical modeling was discussed where the system is treated by a complex and non-linear way. The linear networking of the interested issue was changed by the SD algorithm where the feedback and multiple connections are added to the original networking theory. The non-linear method has shown the complexity of the marketing strategy, especially for the NPP which is the very expensive and safety focused facility.

  10. Modular VSC converter based HVDC power transmission from offshore wind power plant: Compared to the conventional HVAC system

    DEFF Research Database (Denmark)

    Sharma, Ranjan; Rasmussen, Tonny Wederberg; Jensen, Kim Høj

    2010-01-01

    The size of wind power plants (WPPs), both physical and in terms of power rating, is rapidly growing. More and more WPPs are commissioned as offshore as well as the distances from the WPP to the coast are increasing. The problems associated with long HVAC sea-cables are well documented. Alternative...... power transmission options with HVDC systems are under consideration. In this paper, a comparison between a conventional HVAC transmission system and a HVDC system equipped with modular voltage source converters is provided. The comparison is based on the total energy transmission capability...

  11. Laboratory and field based evaluation of chromatography ...

    Science.gov (United States)

    The Monitor for AeRosols and GAses in ambient air (MARGA) is an on-line ion-chromatography-based instrument designed for speciation of the inorganic gas and aerosol ammonium-nitrate-sulfate system. Previous work to characterize the performance of the MARGA has been primarily based on field comparison to other measurement methods to evaluate accuracy. While such studies are useful, the underlying reasons for disagreement among methods are not always clear. This study examines aspects of MARGA accuracy and precision specifically related to automated chromatography analysis. Using laboratory standards, analytical accuracy, precision, and method detection limits derived from the MARGA chromatography software are compared to an alternative software package (Chromeleon, Thermo Scientific Dionex). Field measurements are used to further evaluate instrument performance, including the MARGA’s use of an internal LiBr standard to control accuracy. Using gas/aerosol ratios and aerosol neutralization state as a case study, the impact of chromatography on measurement error is assessed. The new generation of on-line chromatography-based gas and particle measurement systems have many advantages, including simultaneous analysis of multiple pollutants. The Monitor for Aerosols and Gases in Ambient Air (MARGA) is such an instrument that is used in North America, Europe, and Asia for atmospheric process studies as well as routine monitoring. While the instrument has been evaluat

  12. An Exploratory Investigation on Modularity Adoption in Design and Production Through a Case-Based Research in a Brazilian Automaker

    DEFF Research Database (Denmark)

    Cauchick Miguel, Paulo Augusto; Hsuan, Juliana

    2010-01-01

    Many companies in the automotive supply chain have increasingly adopted the concept of modularity. Modularity can be defined as a way of building complex products or processes from smaller subsystems that can be designed independently and yet function together as a whole. There are many dimensions...... of modularity and the most common ones are: modularity-in-design and modularity-in-production. In addition, there are potential tradeoffs between these dimensions, but this issue has not yet been extensively explored in the literature. In this sense, the purpose of this paper is to empirically investigate...

  13. Increasing Efficiency and Quality by Consolidation of Clinical Chemistry and Immunochemistry Systems with MODULAR ANALYTICS SWA

    OpenAIRE

    Mocarelli, Paolo; Horowitz, Gary L.; Gerthoux, Pier Mario; Cecere, Rossana; Imdahl, Roland; Ruinemans-Koerts, Janneke; Luthe, Hilmar; Calatayud, Silvia Pesudo; Salve, Marie Luisa; Kunst, Albert; McGovern, Margaret; Ng, Katherine; Stockmann, Wolfgang

    2008-01-01

    MODULAR ANALYTICS Serum Work Area (in USA Integrated MODULAR ANALYTICS, MODULAR ANALYTICS is a trademark of a member of the Roche Group) represents a further approach to automation in the laboratory medicine. This instrument combines previously introduced modular systems for the clinical chemistry and immunochemistry laboratory and allows customised combinations for various laboratory workloads. Functionality, practicability, and workflow behaviour of MODULAR ANALYTICS Serum Work Area were ev...

  14. A Modular High-Throughput In Vivo Screening Platform Based on Chimeric Bacterial Receptors

    DEFF Research Database (Denmark)

    Lehning, Christina Eva; Heidelberger, Jan B; Reinhard, John

    2017-01-01

    Multidrug resistance (MDR) is a globally relevant problem that requires novel approaches. Two-component systems are a promising, yet untapped target for novel antibacterials. They are prevalent in bacteria and absent in mammals, and their activity can be modulated upon perception of various stimuli...... possess desirable therapeutic properties to combat MDR. We propose that a modular screening platform in which the periplasmic domain of the targeted receptors are fused to the cytoplasmic domain of a well-characterized receptor that governs fluorescence reporter genes could be employed to rapidly screen...

  15. A spectral method to detect community structure based on distance modularity matrix

    Science.gov (United States)

    Yang, Jin-Xuan; Zhang, Xiao-Dong

    2017-08-01

    There are many community organizations in social and biological networks. How to identify these community structure in complex networks has become a hot issue. In this paper, an algorithm to detect community structure of networks is proposed by using spectra of distance modularity matrix. The proposed algorithm focuses on the distance of vertices within communities, rather than the most weakly connected vertex pairs or number of edges between communities. The experimental results show that our method achieves better effectiveness to identify community structure for a variety of real-world networks and computer generated networks with a little more time-consumption.

  16. Control of modular multilevel converters based on time-scale analysis and orthogonal functions

    DEFF Research Database (Denmark)

    Zarri, L.; Tani, A.; Mengoni, M.

    2014-01-01

    Modular multilevel converter (MMC) is a promising multilevel topology for high-voltage applications that has been developed in recent years. The control of MMCs has been analyzed in detail in many papers, showing that the converter capacitors can be kept charged and balanced by controlling...... current is still a complex task and cannot be fully tackled with traditional linear control techniques. In this paper a multiple time-scale analysis is proposed to determine an approximated model of the MMC that can be used to solve the control problem of the capacitor voltages. In addition, it is shown...

  17. The Science of Nuclear Materials: A Modular, Laboratory-based Curriculum

    International Nuclear Information System (INIS)

    Cahill, C.L.; Feldman, G.; Briscoe, W.J.

    2014-01-01

    The development of a curriculum for nuclear materials courses targeting students pursuing Master of Arts degrees at The George Washington University is described. The courses include basic concepts such as radiation and radioactivity as well as more complex topics such the nuclear fuel cycle, nuclear weapons, radiation detection and technological aspects of non-proliferation

  18. Metric modular spaces

    CERN Document Server

    Chistyakov, Vyacheslav

    2015-01-01

    Aimed toward researchers and graduate students familiar with elements of functional analysis, linear algebra, and general topology; this book contains a general study of modulars, modular spaces, and metric modular spaces. Modulars may be thought of as generalized velocity fields and serve two important purposes: generate metric spaces in a unified manner and provide a weaker convergence, the modular convergence, whose topology is non-metrizable in general. Metric modular spaces are extensions of metric spaces, metric linear spaces, and classical modular linear spaces. The topics covered include the classification of modulars, metrizability of modular spaces, modular transforms and duality between modular spaces, metric  and modular topologies. Applications illustrated in this book include: the description of superposition operators acting in modular spaces, the existence of regular selections of set-valued mappings, new interpretations of spaces of Lipschitzian and absolutely continuous mappings, the existe...

  19. Simulation-Based System Design Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — The research objective is to develop, test, and implement effective and efficient simulation techniques for modeling, evaluating, and optimizing systems in order to...

  20. Modularized seismic full waveform inversion based on waveform sensitivity kernels - The software package ASKI

    Science.gov (United States)

    Schumacher, Florian; Friederich, Wolfgang; Lamara, Samir; Gutt, Phillip; Paffrath, Marcel

    2015-04-01

    We present a seismic full waveform inversion concept for applications ranging from seismological to enineering contexts, based on sensitivity kernels for full waveforms. The kernels are derived from Born scattering theory as the Fréchet derivatives of linearized frequency-domain full waveform data functionals, quantifying the influence of elastic earth model parameters and density on the data values. For a specific source-receiver combination, the kernel is computed from the displacement and strain field spectrum originating from the source evaluated throughout the inversion domain, as well as the Green function spectrum and its strains originating from the receiver. By storing the wavefield spectra of specific sources/receivers, they can be re-used for kernel computation for different specific source-receiver combinations, optimizing the total number of required forward simulations. In the iterative inversion procedure, the solution of the forward problem, the computation of sensitivity kernels and the derivation of a model update is held completely separate. In particular, the model description for the forward problem and the description of the inverted model update are kept independent. Hence, the resolution of the inverted model as well as the complexity of solving the forward problem can be iteratively increased (with increasing frequency content of the inverted data subset). This may regularize the overall inverse problem and optimizes the computational effort of both, solving the forward problem and computing the model update. The required interconnection of arbitrary unstructured volume and point grids is realized by generalized high-order integration rules and 3D-unstructured interpolation methods. The model update is inferred solving a minimization problem in a least-squares sense, resulting in Gauss-Newton convergence of the overall inversion process. The inversion method was implemented in the modularized software package ASKI (Analysis of Sensitivity

  1. A Modular Framework for EEG Web Based Binary Brain Computer Interfaces to Recover Communication Abilities in Impaired People.

    Science.gov (United States)

    Placidi, Giuseppe; Petracca, Andrea; Spezialetti, Matteo; Iacoviello, Daniela

    2016-01-01

    A Brain Computer Interface (BCI) allows communication for impaired people unable to express their intention with common channels. Electroencephalography (EEG) represents an effective tool to allow the implementation of a BCI. The present paper describes a modular framework for the implementation of the graphic interface for binary BCIs based on the selection of symbols in a table. The proposed system is also designed to reduce the time required for writing text. This is made by including a motivational tool, necessary to improve the quality of the collected signals, and by containing a predictive module based on the frequency of occurrence of letters in a language, and of words in a dictionary. The proposed framework is described in a top-down approach through its modules: signal acquisition, analysis, classification, communication, visualization, and predictive engine. The framework, being modular, can be easily modified to personalize the graphic interface to the needs of the subject who has to use the BCI and it can be integrated with different classification strategies, communication paradigms, and dictionaries/languages. The implementation of a scenario and some experimental results on healthy subjects are also reported and discussed: the modules of the proposed scenario can be used as a starting point for further developments, and application on severely disabled people under the guide of specialized personnel.

  2. Laboratory Grouping Based on Previous Courses.

    Science.gov (United States)

    Doemling, Donald B.; Bowman, Douglas C.

    1981-01-01

    In a five-year study, second-year human physiology students were grouped for laboratory according to previous physiology and laboratory experience. No significant differences in course or board examination performance were found, though correlations were found between predental grade-point averages and grouping. (MSE)

  3. The total laboratory solution: a new laboratory E-business model based on a vertical laboratory meta-network.

    Science.gov (United States)

    Friedman, B A

    2001-08-01

    Major forces are now reshaping all businesses on a global basis, including the healthcare and clinical laboratory industries. One of the major forces at work is information technology (IT), which now provides the opportunity to create a new economic and business model for the clinical laboratory industry based on the creation of an integrated vertical meta-network, referred to here as the "total laboratory solution" (TLS). Participants at the most basic level of such a network would include a hospital-based laboratory, a reference laboratory, a laboratory information system/application service provider/laboratory portal vendor, an in vitro diagnostic manufacturer, and a pharmaceutical/biotechnology manufacturer. It is suggested that each of these participants would add value to the network primarily in its area of core competency. Subvariants of such a network have evolved over recent years, but a TLS comprising all or most of these participants does not exist at this time. Although the TLS, enabled by IT and closely akin to the various e-businesses that are now taking shape, offers many advantages from a theoretical perspective over the current laboratory business model, its success will depend largely on (a) market forces, (b) how the collaborative networks are organized and managed, and (c) whether the network can offer healthcare organizations higher quality testing services at lower cost. If the concept is successful, new demands will be placed on hospital-based laboratory professionals to shift the range of professional services that they offer toward clinical consulting, integration of laboratory information from multiple sources, and laboratory information management. These information management and integration tasks can only increase in complexity in the future as new genomic and proteomics testing modalities are developed and come on-line in clinical laboratories.

  4. Age-dependent changes in task-based modular organization of the human brain.

    Science.gov (United States)

    Schlesinger, Kimberly J; Turner, Benjamin O; Lopez, Brian A; Miller, Michael B; Carlson, Jean M

    2017-02-01

    As humans age, cognition and behavior change significantly, along with associated brain function and organization. Aging has been shown to decrease variability in functional magnetic resonance imaging (fMRI) signals, and to affect the modular organization of human brain function. In this work, we use complex network analysis to investigate the dynamic community structure of large-scale brain function, asking how evolving communities interact with known brain systems, and how the dynamics of communities and brain systems are affected by age. We analyze dynamic networks derived from fMRI scans of 104 human subjects performing a word memory task, and determine the time-evolving modular structure of these networks by maximizing the multislice modularity, thereby identifying distinct communities, or sets of brain regions with strong intra-set functional coherence. To understand how community structure changes over time, we examine the number of communities as well as the flexibility, or the likelihood that brain regions will switch between communities. We find a significant positive correlation between age and both these measures: younger subjects tend to have less fragmented and more coherent communities, and their brain regions tend to change communities less often during the memory task. We characterize the relationship of community structure to known brain systems by the recruitment coefficient, or the probability of a brain region being grouped in the same community as other regions in the same system. We find that regions associated with cingulo-opercular, somatosensory, ventral attention, and subcortical circuits have a significantly higher recruitment coefficient in younger subjects. This indicates that the within-system functional coherence of these specific systems during the memory task declines with age. Such a correspondence does not exist for other systems (e.g. visual and default mode), whose recruitment coefficients remain relatively uniform across ages

  5. Understanding Socio Technical Modularity

    DEFF Research Database (Denmark)

    Thuesen, Christian Langhoff; Kudsk, Anders; Hvam, Lars

    2011-01-01

    dimension of modularity like irrational behaviors, cultural differences, learning processes, social organization and institutional influences on modularity. The paper addresses this gab offering a reinterpretation of the modularity concept from a socio-technical perspective in general and Actor Network...... Theory in particular. By formulating modularity from an ANT perspective covering social, material and process aspects, the modularity of a socio-technical system can be understood as an entanglement of product, process, organizational and institutional modularity. The theoretical framework is illustrated...

  6. Towards Python-based Domain-specific Languages for Self-reconfigurable Modular Robotics Research

    DEFF Research Database (Denmark)

    Moghadam, Mikael; Johan Christensen, David; Brandt, David

    2013-01-01

    This paper explores the role of operating system and high-level languages in the development of software and domain-specific languages (DSLs) for self-reconfigurable robotics. We review some of the current trends in self-reconfigurable robotics and describe the development of a software system...... for ATRON II which utilizes Linux and Python to significantly improve software abstraction and portability while providing some basic features which could prove useful when using Python, either stand-alone or via a DSL, on a self-reconfigurable robot system. These features include transparent socket...... communication, module identification, easy software transfer and reliable module-to-module communication. The end result is a software platform for modular robots that where appropriate builds on existing work in operating systems, virtual machines, middleware and high-level languages....

  7. Towards Python-based Domain-specific Languages for Self-reconfigurable Modular Robotics Research

    DEFF Research Database (Denmark)

    Moghadam, Mikael; Christensen, David Johan; Brandt, David

    2011-01-01

    This paper explores the role of operating system and high-level languages in the development of software and domain-specific languages (DSLs) for self-reconfigurable robotics. We review some of the current trends in selfreconfigurable robotics and describe the development of a software system...... for ATRON II which utilizes Linux and Python to significantly improve software abstraction and portability while providing some basic features which could prove useful when using Python, either stand-alone or via a DSL, on a selfreconfigurable robot system. These features include transparent socket...... communication, module identification, easy software transfer and reliable module-to-module communication. The end result is a software platform for modular robots that where appropriate builds on existing work in operating systems, virtual machines, middleware and high-level languages....

  8. AES Modular Power Systems

    Data.gov (United States)

    National Aeronautics and Space Administration — The AES Modular Power Systems (AMPS) project will demonstrate and infuse modular power electronics, batteries, fuel cells, and autonomous control for exploration...

  9. A 13-Week Research-Based Biochemistry Laboratory Curriculum

    Science.gov (United States)

    Lefurgy, Scott T.; Mundorff, Emily C.

    2017-01-01

    Here, we present a 13-week research-based biochemistry laboratory curriculum designed to provide the students with the experience of engaging in original research while introducing foundational biochemistry laboratory techniques. The laboratory experience has been developed around the directed evolution of an enzyme chosen by the instructor, with…

  10. A Web-Based Remote Access Laboratory Using SCADA

    Science.gov (United States)

    Aydogmus, Z.; Aydogmus, O.

    2009-01-01

    The Internet provides an opportunity for students to access laboratories from outside the campus. This paper presents a Web-based remote access real-time laboratory using SCADA (supervisory control and data acquisition) control. The control of an induction motor is used as an example to demonstrate the effectiveness of this remote laboratory,…

  11. A modular architecture for multi-channel external cavity quantum cascade laser-based chemical sensors: a systems approach

    Energy Technology Data Exchange (ETDEWEB)

    Taubman, Matthew S.; Myers, Tanya L.; Bernacki, Bruce E.; Stahl, Robert D.; Cannon, Bret D.; Schiffern, John T.; Phillips, Mark C.

    2012-04-01

    A multi-channel laser-based chemical sensor platform is presented, in which a modular architecture allows the exchange of complete sensor channels without disruption to overall operation. Each sensor channel contains custom optical and electronics packages, which can be selected to access laser wavelengths, interaction path lengths and modulation techniques optimal for a given application or mission. Although intended primarily to accommodate mid-infrared (MIR) external cavity quantum cascade lasers (ECQCLs)and astigmatic Herriott cells, channels using visible or near infrared (NIR) lasers or other gas cell architectures can also be used, making this a truly versatile platform. Analog and digital resources have been carefully chosen to facilitate small footprint, rapid spectral scanning, ow-noise signal recovery, failsafe autonomous operation, and in-situ chemometric data analysis, storage and transmission. Results from the demonstration of a two-channel version of this platform are also presented.

  12. Development and integration of a LabVIEW-based modular architecture for automated execution of electrochemical catalyst testing.

    Science.gov (United States)

    Topalov, Angel A; Katsounaros, Ioannis; Meier, Josef C; Klemm, Sebastian O; Mayrhofer, Karl J J

    2011-11-01

    This paper describes a system for performing electrochemical catalyst testing where all hardware components are controlled simultaneously using a single LabVIEW-based software application. The software that we developed can be operated in both manual mode for exploratory investigations and automatic mode for routine measurements, by using predefined execution procedures. The latter enables the execution of high-throughput or combinatorial investigations, which decrease substantially the time and cost for catalyst testing. The software was constructed using a modular architecture which simplifies the modification or extension of the system, depending on future needs. The system was tested by performing stability tests of commercial fuel cell electrocatalysts, and the advantages of the developed system are discussed. © 2011 American Institute of Physics

  13. A flexible, extendable, modular and computationally efficient approach to scattering-integral-based seismic full waveform inversion

    Science.gov (United States)

    Schumacher, F.; Friederich, W.; Lamara, S.

    2016-02-01

    We present a new conceptual approach to scattering-integral-based seismic full waveform inversion (FWI) that allows a flexible, extendable, modular and both computationally and storage-efficient numerical implementation. To achieve maximum modularity and extendability, interactions between the three fundamental steps carried out sequentially in each iteration of the inversion procedure, namely, solving the forward problem, computing waveform sensitivity kernels and deriving a model update, are kept at an absolute minimum and are implemented by dedicated interfaces. To realize storage efficiency and maximum flexibility, the spatial discretization of the inverted earth model is allowed to be completely independent of the spatial discretization employed by the forward solver. For computational efficiency reasons, the inversion is done in the frequency domain. The benefits of our approach are as follows: (1) Each of the three stages of an iteration is realized by a stand-alone software program. In this way, we avoid the monolithic, unflexible and hard-to-modify codes that have often been written for solving inverse problems. (2) The solution of the forward problem, required for kernel computation, can be obtained by any wave propagation modelling code giving users maximum flexibility in choosing the forward modelling method. Both time-domain and frequency-domain approaches can be used. (3) Forward solvers typically demand spatial discretizations that are significantly denser than actually desired for the inverted model. Exploiting this fact by pre-integrating the kernels allows a dramatic reduction of disk space and makes kernel storage feasible. No assumptions are made on the spatial discretization scheme employed by the forward solver. (4) In addition, working in the frequency domain effectively reduces the amount of data, the number of kernels to be computed and the number of equations to be solved. (5) Updating the model by solving a large equation system can be

  14. Modular Assembly of Cell-targeting Devices Based on an Uncommon G-quadruplex Aptamer

    Directory of Open Access Journals (Sweden)

    Felipe Opazo

    2015-01-01

    Full Text Available Aptamers are valuable tools that provide great potential to develop cost-effective diagnostics and therapies in the biomedical field. Here, we report a novel DNA aptamer that folds into an unconventional G-quadruplex structure able to recognize and enter specifically into human Burkitt's lymphoma cells. We further optimized this aptamer to a highly versatile and stable minimized version. The minimized aptamer can be easily equipped with different functionalities like quantum dots, organic dyes, or even a second different aptamer domain yielding a bi-paratopic aptamer. Although the target molecule of the aptamer remains unknown, our microscopy and pharmacological studies revealed that the aptamer hijacks the clathrin-mediated endocytosis pathway for its cellular internalization. We conclude that this novel class of aptamers can be used as a modular tool to specifically deliver different cargoes into malignant cells. This work provides a thorough characterization of the aptamer and we expect that our strategy will pave the path for future therapeutic applications.

  15. Modular simulation software development for liquid propellant rocket engines based on MATLAB Simulink

    Directory of Open Access Journals (Sweden)

    Naderi Mahyar

    2017-01-01

    Full Text Available Focusing on Liquid Propellant Rocket Engine (LPRE major components, a steady state modular simulation software has been established in MATLAB Simulink. For integrated system analysis, a new algorithm dependant on engine inlet mass flow rate and pressure is considered. Using the suggested algorithm, it is possible to evaluate engine component operation, similar to the known initial parameters during hot fire test of the engine on stand. As a case study, the reusable Space Shuttle Main Engine (SSME has been selected and the simulation has been performed to predict engine’s throttled operation at 109 percent of the nominal thrust value. For this purpose the engine actual flow diagram has been converted to 34 numerical modules and the engine has been modelled by solving a total of 101 steady state mathematic equations. The mean error of the simulation results is found to be less than 5% compared with the published SSME data. Using the presented idea and developed modules, it is possible to build up the numerical model and simulate other LPREs.

  16. A modular CUDA-based framework for scale-space feature detection in video streams

    International Nuclear Information System (INIS)

    Kinsner, M; Capson, D; Spence, A

    2010-01-01

    Multi-scale image processing techniques enable extraction of features where the size of a feature is either unknown or changing, but the requirement to process image data at multiple scale levels imposes a substantial computational load. This paper describes the architecture and emerging results from the implementation of a GPGPU-accelerated scale-space feature detection framework for video processing. A discrete scale-space representation is generated for image frames within a video stream, and multi-scale feature detection metrics are applied to detect ridges and Gaussian blobs at video frame rates. A modular structure is adopted, in which common feature extraction tasks such as non-maximum suppression and local extrema search may be reused across a variety of feature detectors. Extraction of ridge and blob features is achieved at faster than 15 frames per second on video sequences from a machine vision system, utilizing an NVIDIA GTX 480 graphics card. By design, the framework is easily extended to additional feature classes through the inclusion of feature metrics to be applied to the scale-space representation, and using common post-processing modules to reduce the required CPU workload. The framework is scalable across multiple and more capable GPUs, and enables previously intractable image processing at video frame rates using commodity computational hardware.

  17. Sandia National Laboratories analysis code data base

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, C.W.

    1994-11-01

    Sandia National Laboratories, mission is to solve important problems in the areas of national defense, energy security, environmental integrity, and industrial technology. The Laboratories` strategy for accomplishing this mission is to conduct research to provide an understanding of the important physical phenomena underlying any problem, and then to construct validated computational models of the phenomena which can be used as tools to solve the problem. In the course of implementing this strategy, Sandia`s technical staff has produced a wide variety of numerical problem-solving tools which they use regularly in the design, analysis, performance prediction, and optimization of Sandia components, systems and manufacturing processes. This report provides the relevant technical and accessibility data on the numerical codes used at Sandia, including information on the technical competency or capability area that each code addresses, code ``ownership`` and release status, and references describing the physical models and numerical implementation.

  18. Specification for modular plug-in unit and standard 19-inch rack mounting unit based on NIM standard (for electronic nuclear instruments)

    International Nuclear Information System (INIS)

    1978-01-01

    The object is to define standard dimensions of a modular system based on NIM standard and comprising the plug-in unit Type N specified in IEC Publication 482, Dimensions of Electronic Instrument Modules (for Nuclear Electronic Instruments), the corresponding 19-inch rack mounting unit Type NC (conforming to IEC Publication 297, Dimensions of Panels and Racks) and the associated connectors. (author)

  19. Community vs. Clinic-Based Modular Treatment of Children with Early-Onset ODD or CD: A Clinical Trial with 3-Year Follow-Up

    Science.gov (United States)

    Kolko, David J.; Dorn, Lorah D.; Bukstein, Oscar G.; Pardini, Dustin; Holden, Elizabeth A.; Hart, Jonathan

    2009-01-01

    This study examines the treatment outcomes of 139, 6-11 year-old, clinically referred boys and girls diagnosed with Oppositional Defiant Disorder (ODD) or Conduct Disorder (CD) who were randomly assigned to a modular-based treatment protocol that was applied by research study clinicians either in the community (COMM) or a clinic office (CLINIC).…

  20. [Germ cell tumors - documentation of diagnosis and therapy by means of a web-based modular database system].

    Science.gov (United States)

    Schreiter, N; Jagota, A; Popken, G; Akhavuz, O; Nitzke, T; Düffelmeyer, M; Fischer, T; Schostak, M; Miller, K; Schrader, M

    2008-11-01

    Health telematics is gaining ground worldwide as it promises the bridging of distances in space and time as well as a highly effective use of financial and other resources. In Germany the development and introduction of a national telematic platform is in the foreground at present. However, there are a number of more specialised projects already in existence. The aim of this study was to develop an internet platform to document the quality of individual sections of treatment for patients with germ cell tumours in Berlin and to improve the therapy in conformity with the S2 guidelines. As a pilot project, a web-based modular database system (WBMDS) was developed, which can be used by any physician involved in the treatment of germ cell tumour patients from any computer connected to the internet. The WBMDS proved to be a practicable system of documentation. Data protection was ensured by pseudonyms as well as symmetrical and asymmetrical coding. The size of the extended documentation mask that had initially seemed to be necessary for valid documentation appeared to be too user-unfriendly with its 833 items. To meet the requirements of the user as well as of the documentation, a compact variant with 496 input fields was designed. On a random basis, treatment not in conformity with the guidelines could be detected in 20 % of 151 patients with the help of this system. For the successful use of an oncological database the following showed to be essential:[nl]Queries clearly defined for later statistical evaluation,[nl]clear separation between the phases of planning and implementation,[nl]a size of the database that does not make excessive demands on the user,[nl]intensive training of the users.[nl]The modular database system established proved to be well suitable for a quality-ensuring longitudinal case documentation, which can also be applied to other tumour entities.

  1. A REST-ful interpretation for embedded modular systems based on open architecture

    Science.gov (United States)

    Lyke, James

    2016-05-01

    The much-anticipated revolution of the "Internet of things" (IoT) is expected to generate one trillion internet devices within the next 15 years, mostly in the form of simple wireless sensor devices. While this revolution promises to transform silicon markets and drive a number of disruptive changes in society, it is also the case that the protocols, complexity, and security issues of extremely large dynamic, co-mingled networks is still poorly understood. Furthermore, embedded system developers, to include military and aerospace users, have largely ignored the potential (good and bound) of the cloudlike, possibly intermingling networks having variable structure to how future systems might be engineered. In this paper, we consider a new interpretation of IoT inspired modular architecture strategies involving the representational state transfer (REST) model, in which dynamic networks with variable structure employ stateless application programming interface (API) concepts. The power of the method, which extends concepts originally developed for space plug-and-play avionics, is that it allows for the fluid co-mingling of hardware and software in networks whose structure can overlap and evolve. Paradoxically, these systems may have the most stringent determinism and fault-tolerant needs. In this paper we review how RESTful APIs can potentially be used to design, create, test, and deploy systems rapidly while addressing security and referential integrity even when the nodes of many systems might physically co-mingle. We will also explore ways to take advantage of the RESTful paradigm for fault tolerance and what extensions might be necessary to deal with high-performance and determinism.

  2. Modular remote radiation monitor

    International Nuclear Information System (INIS)

    Lacerda, Fabio; Farias, Marcos S.; Aghina, Mauricio A.C.; Oliveira, Mauro V.

    2013-01-01

    The Modular Remote Radiation Monitor (MRRM) is a novel radiation monitor suitable for monitoring environmental exposure to ionizing radiation. It is a portable compact-size low-power microprocessor-based electronic device which provides its monitoring data to other electronic systems, physically distant from it, by means of an electronic communication channel, which can be wired or wireless according to the requirements of each application. Besides its low-power highly-integrated circuit design, the Modular Remote Radiation Monitor is presented in a modular architecture, which promotes full compliance to the technical requirements of different applications while minimizing cost, size and power consumption. Its communication capability also supports the implementation of a network of multiple radiation monitors connected to a supervisory system, capable of remotely controlling each monitor independently as well as visualizing the radiation levels from all monitors. A prototype of the MRRM, functionally equivalent to the MRA-7027 radiation monitor, was implemented and connected to a wired MODBUS network of MRA-7027 monitors, responsible for monitoring ionizing radiation inside Argonauta reactor room at Instituto de Engenharia Nuclear. Based on the highly positive experimental results obtained, further design is currently underway in order to produce a consumer version of the MRRM. (author)

  3. Phenomena identification ranking table and knowledge base gaps and needs for the modular high-temperature gas-cooled reactor

    International Nuclear Information System (INIS)

    Tokuhiro, Akira; Potirniche, Gabriel; Rink, Karl

    2009-01-01

    The U.S. is developing a modular high-temperature gas-cooled reactor (MHTGR) under the Next Generation Nuclear Plant (NGNP); also known as the Very High Temperature Reactor (VHTR). The generic MHTGR is a graphite-moderated, gas-cooled reactor (GCR) of either a prismatic modular (block-type, PMR) or pebble-bed (PBR) core configuration. The pebble-bed design requires new attention with respect to neutronics, materials, thermal hydraulic, safety and licensing relative to the set of phenomena and engineering analyses associated with the current fleet of legacy LWRs. In fact, the relative knowledge and experiential base on gas reactors is small in comparison to the LWR. There is a dated body of knowledge from some 25+ years ago on GCRs; recently there is a renewed interest. Thus in the present design and development phase of the NGNP/VHTR, there are relevant thermohydraulic safety issues surrounding the MHTGR with issues impacting foremost the design review process. A common phenomena with respect to PMR and PBR core design, is that concerning 'graphite dust' and its interaction and transport with potential fission products (FP) that may be present within the graphite and subsequently in the primary system. The nature of the graphite and FPs, when circulated or transported in the primary, and possibly beyond, is of concern as potentially an relevant 'source term' (radionuclide inventory) of the MHTGR. Based on NUREG/CR-6944, Volumes 1-5, the author briefly describes the state-of-the art knowledge base on graphite dust and FP transport with respect to the anticipated design of the MHTGR. In addition, from the Phenomena Identification and Ranking Tables (PIRTs) developed in these reports we concurrently identify and describe 'gaps and needs' of the knowledge base. That is, we also present the knowledge base gaps and needs with respect to the following: 1) R and D needs relative to PIRTs, 2) (experimental) database needs relative to PIRTs, and 3) simulation and modeling

  4. Trichocyanines: a Red-Hair-Inspired Modular Platform for Dye-Based One-Time-Pad Molecular Cryptography.

    Science.gov (United States)

    Leone, Loredana; Pezzella, Alessandro; Crescenzi, Orlando; Napolitano, Alessandra; Barone, Vincenzo; d'Ischia, Marco

    2015-06-01

    Current molecular cryptography (MoCryp) systems are almost exclusively based on DNA chemistry and reports of cryptography technologies based on other less complex chemical systems are lacking. We describe herein, as proof of concept, the prototype of the first asymmetric MoCryp system, based on an 8-compound set of a novel bioinspired class of cyanine-type dyes called trichocyanines. These novel acidichromic cyanine-type dyes inspired by red hair pigments were synthesized and characterized with the aid of density functional theory (DFT) calculations. Trichocyanines consist of a modular scaffold easily accessible via an expedient condensation of 3-phenyl- or 3-methyl-2H-1,4-benzothiazines with N-dimethyl- or o-methoxyhydroxy-substituted benzaldehyde or cinnamaldehyde derivatives. The eight representative members synthesized herein can be classified as belonging to two three-state systems tunable through four different control points. This versatile dye platform can generate an expandable palette of colors and appears to be specifically suited to implement an unprecedented single-use asymmetric molecular cryptography system. With this system, we intend to pioneer the translation of digital public-key cryptography into a chemical-coding one-time-pad-like system.

  5. Cloud-Based Virtual Laboratory for Network Security Education

    Science.gov (United States)

    Xu, Le; Huang, Dijiang; Tsai, Wei-Tek

    2014-01-01

    Hands-on experiments are essential for computer network security education. Existing laboratory solutions usually require significant effort to build, configure, and maintain and often do not support reconfigurability, flexibility, and scalability. This paper presents a cloud-based virtual laboratory education platform called V-Lab that provides a…

  6. Determination of Absolute Zero Using a Computer-Based Laboratory

    Science.gov (United States)

    Amrani, D.

    2007-01-01

    We present a simple computer-based laboratory experiment for evaluating absolute zero in degrees Celsius, which can be performed in college and undergraduate physical sciences laboratory courses. With a computer, absolute zero apparatus can help demonstrators or students to observe the relationship between temperature and pressure and use…

  7. An Accelerated Development, Reduced Cost Approach to Lunar/Mars Exploration Using a Modular NTR-Based Space Transportation System

    Science.gov (United States)

    Borowski, S.; Clark, J.; Sefcik, R.; Corban, R.; Alexander, S.

    1995-01-01

    The results of integrated systems and mission studies are presented which quantify the benefits and rationale for developing a common, modular lunar/Mars space transportation system (STS) based on nuclear thermal rocket (NTR) technology. At present NASA's Exploration Program Office (ExPO) is considering chemical propulsion for an 'early return to the Moon' and NTR propulsion for the more demanding Mars missions to follow. The time and cost to develop these multiple systems are expected to be significant. The Nuclear Propulsion Office (NPO) has examined a variety of lunar and Mars missions and heavy lift launch vehicle (HLLV) options in an effort to determine a 'standardized' set of engine and stage components capable of satisfying a wide range of Space Exploration Initiative (SEI) missions. By using these components in a 'building block' fashion, a variety of single and multi-engine lunar and Mars vehicles can be configured. For NASA's 'First Lunar Outpost' (FLO) mission, an expendable NTR stage powered by two 50 klbf engines can deliver approximately 96 metric tons (t) to translunar injection (TLI) conditions for an initial mass in low earth orbit (IMLEO) of approximately 198 t compared to 250 t for a cryogenic chemical TLI stage. The NTR stage liquid hydrogen (LH2) tank has a 10 m diameter, 14.5 m length, and 66 t LH2 capacity. The NTR utilizes a UC-ZrC-graphite 'composite' fuel with a specific impulse (Isp) capability of approximately 900 s and an engine thrust-to-weight ratio of approximately 4.3. By extending the size and LH2 capacity of the lunar NTR stage to approximately 20 m and 96 t, respectively, a single launch Mars cargo vehicle capable of delivering approximately 50 t of surface payload is possible. Three 50 klbf NTR engines and the two standardized LH2 tank sizes developed for lunar and Mars cargo vehicle applications would be used to configure the Mars piloted vehicle for a mission as early as 2010. The paper describes the features of the 'common

  8. Virtual Planning, Control, and Machining for a Modular-Based Automated Factory Operation in an Augmented Reality Environment.

    Science.gov (United States)

    Pai, Yun Suen; Yap, Hwa Jen; Md Dawal, Siti Zawiah; Ramesh, S; Phoon, Sin Ye

    2016-06-07

    This study presents a modular-based implementation of augmented reality to provide an immersive experience in learning or teaching the planning phase, control system, and machining parameters of a fully automated work cell. The architecture of the system consists of three code modules that can operate independently or combined to create a complete system that is able to guide engineers from the layout planning phase to the prototyping of the final product. The layout planning module determines the best possible arrangement in a layout for the placement of various machines, in this case a conveyor belt for transportation, a robot arm for pick-and-place operations, and a computer numerical control milling machine to generate the final prototype. The robotic arm module simulates the pick-and-place operation offline from the conveyor belt to a computer numerical control (CNC) machine utilising collision detection and inverse kinematics. Finally, the CNC module performs virtual machining based on the Uniform Space Decomposition method and axis aligned bounding box collision detection. The conducted case study revealed that given the situation, a semi-circle shaped arrangement is desirable, whereas the pick-and-place system and the final generated G-code produced the highest deviation of 3.83 mm and 5.8 mm respectively.

  9. Virtual Planning, Control, and Machining for a Modular-Based Automated Factory Operation in an Augmented Reality Environment

    Science.gov (United States)

    Pai, Yun Suen; Yap, Hwa Jen; Md Dawal, Siti Zawiah; Ramesh, S.; Phoon, Sin Ye

    2016-01-01

    This study presents a modular-based implementation of augmented reality to provide an immersive experience in learning or teaching the planning phase, control system, and machining parameters of a fully automated work cell. The architecture of the system consists of three code modules that can operate independently or combined to create a complete system that is able to guide engineers from the layout planning phase to the prototyping of the final product. The layout planning module determines the best possible arrangement in a layout for the placement of various machines, in this case a conveyor belt for transportation, a robot arm for pick-and-place operations, and a computer numerical control milling machine to generate the final prototype. The robotic arm module simulates the pick-and-place operation offline from the conveyor belt to a computer numerical control (CNC) machine utilising collision detection and inverse kinematics. Finally, the CNC module performs virtual machining based on the Uniform Space Decomposition method and axis aligned bounding box collision detection. The conducted case study revealed that given the situation, a semi-circle shaped arrangement is desirable, whereas the pick-and-place system and the final generated G-code produced the highest deviation of 3.83 mm and 5.8 mm respectively. PMID:27271840

  10. Biosensors based on modularly designed synthetic peptides for recognition, detection and live/dead differentiation of pathogenic bacteria.

    Science.gov (United States)

    Liu, Xiaobo; Marrakchi, Mouna; Xu, Dawei; Dong, He; Andreescu, Silvana

    2016-06-15

    Rapid and sensitive detection of bacterial pathogens is critical for assessing public health, food and environmental safety. We report the use of modularly designed and site-specifically oriented synthetic antimicrobial peptides (sAMPs) as novel recognition agents enabling detection and quantification of bacterial pathogens. The oriented assembly of the synthetic peptides on electrode surfaces through an engineered cysteine residue coupled with impedimetric detection facilitated rapid and sensitive detection of bacterial pathogens with a detection limit of 10(2)CFU/mL for four bacterial strains including Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa), Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermidis). The approach enabled differentiation between live and dead bacteria. The fabrication of the sAMPs functionalized surface and the importance of the sAMPs orientation for providing optimum recognition and detection ability against pathogens are discussed. The proposed methodology provides a universal platform for the detection of bacterial pathogens based on engineered peptides, as alternative to the most commonly used immunological and gene based assays. The method can also be used to fabricate antimicrobial coatings and surfaces for inactivation and screening of viable bacteria. Copyright © 2016 Elsevier B.V. All rights reserved.

  11. A Network-Based Electrical Engineering Laboratory

    Science.gov (United States)

    Asimopoulos, Nikolaos D.; Kyriakos, Nathanail; Mpatzakis, Vlasios

    2007-01-01

    Technical education is, by definition, a field that requires hands-on practice and experience by the student. When it comes to distant learning, technical education suffers from lack of such practical study, given the fact that e-learning is based on theoretical material being provided remotely to the student. This article presents the idea of…

  12. Web-based applications for virtual laboratories

    NARCIS (Netherlands)

    Bier, H.H.

    2011-01-01

    Web-based applications for academic education facilitate, usually, exchange of multimedia files, while design-oriented domains such as architectural and urban design require additional support in collaborative real-time drafting and modeling. In this context, multi-user interactive interfaces

  13. Investigating Electromagnetic Induction through a Microcomputer-Based Laboratory.

    Science.gov (United States)

    Trumper, Ricardo; Gelbman, Moshe

    2000-01-01

    Describes a microcomputer-based laboratory experiment designed for high school students that very accurately analyzes Faraday's law of electromagnetic induction, addressing each variable separately while the others are kept constant. (Author/CCM)

  14. Modularity and Economic Organization

    DEFF Research Database (Denmark)

    Sanchez, Ron; Mahoney, Joseph T.

    and the nature of product market competition, (ii) the organization designs firms may adopt and the industry structures that can result when significant numbers of firms adopt modular product architectures, and (iii) learning processes and knowledge structures at the firm and industry levels in modular product......This paper addresses modularity as a basis for organizing economic activity. We first define the key concepts of architecture and of modularity as a special form of architecture. We then suggest how modular systems of all types may exhibit several properties of fundamental importance...... to the organization of economic activities, including greater adaptability and evolvability than systems that lack modular properties. We draw extensively on our original 1996 paper on modularity and subsequent research to suggest broad theoretical implications of modularity for (i) firms' product strategies...

  15. A Novel Modulation Function-Based Control of Modular Multilevel Converters for High Voltage Direct Current Transmission Systems

    Directory of Open Access Journals (Sweden)

    Majid Mehrasa

    2016-10-01

    Full Text Available In this paper, a novel modulation function-based method including analyses of the modulation index and phase is proposed for operation of modular multilevel converters (MMCs in high voltage direct current (HVDC transmission systems. The proposed modulation function-based control technique is developed based on thorough and precise analyses of all MMC voltages and currents in the a-b-c reference frame in which the alternating current (AC-side voltage is the first target to be obtained. Using the AC-side voltage, the combination of the MMC upper and lower arm voltages is achieved as the main structure of the proposed modulation function. The main contribution of this paper is to obtain two very simple new modulation functions to control MMC performance in different operating conditions. The features of the modulation function-based control technique are as follows: (1 this control technique is very simple and can be easily achieved in a-b-c reference frame without the need of using Park transformation; and (2 in addition, the inherent properties of the MMC model are considered in the proposed control technique. Considering these properties leads to constructing a control technique that is robust against MMC parameters changes and also is a very good tracking method for the components of MMC input currents. These features lead to improving the operation of MMC significantly, which can act as a rectifier in the HVDC structure. The simulation studies are conducted through MATLAB/SIMULINK software, and the results obtained verify the effectiveness of the proposed modulation function-based control technique.

  16. Modular system design and evaluation

    CERN Document Server

    Levin, Mark Sh

    2015-01-01

    This book examines seven key combinatorial engineering frameworks (composite schemes consisting of algorithms and/or interactive procedures) for hierarchical modular (composite) systems. These frameworks are based on combinatorial optimization problems (e.g., knapsack problem, multiple choice problem, assignment problem, morphological clique problem), with the author’s version of morphological design approach – Hierarchical Morphological Multicritieria Design (HMMD) – providing a conceptual lens with which to elucidate the examples discussed. This approach is based on ordinal estimates of design alternatives for systems parts/components, however, the book also puts forward an original version of HMMD that is based on new interval multiset estimates for the design alternatives with special attention paid to the aggregation of modular solutions (system versions). The second part of ‘Modular System Design and Evaluation’ provides ten information technology case studies that enriches understanding of th...

  17. Modularized and water-cooled photo-catalyst cleaning devices for aquaponics based on ultraviolet light-emitting diodes

    Science.gov (United States)

    Yang, Henglong; Lung, Louis; Wei, Yu-Chien; Huang, Yi-Bo; Chen, Zi-Yu; Chou, Yu-Yang; Lin, Anne-Chin

    2017-08-01

    The feasibility of applying ultraviolet light-emitting diodes (UV-LED's) as triggering sources of photo-catalyst based on titanium dioxide (TiO2) nano-coating specifically for water-cleaning process in an aquaponics system was designed and proposed. The aquaponics system is a modern farming system to integrate aquaculture and hydroponics into a single system to establish an environmental-friendly and lower-cost method for farming fish and vegetable all together in urban area. Water treatment in an aquaponics system is crucial to avoid mutual contamination. we proposed a modularized watercleaning device composed of all commercially available components and parts to eliminate organic contaminants by using UV-LED's for TiO2 photo-catalyst reaction. This water-cleaning module consisted of two coaxial hollowed cylindrical pipes can be submerged completely in water for water treatment and cooling UV-LED's. The temperature of the UV-LED after proper thermal management can be reduced about 16% to maintain the optimal operation condition. Our preliminary experimental result by using Methylene Blue solution to simulate organic contaminants indicated that TiO2 photo-catalyst triggered by UV-LED's can effectively decompose organic compound and decolor Methylene Blue solution.

  18. Portable modular detection system

    Energy Technology Data Exchange (ETDEWEB)

    Brennan, James S [Rodeo, CA; Singh, Anup [Danville, CA; Throckmorton, Daniel J [Tracy, CA; Stamps, James F [Livermore, CA

    2009-10-13

    Disclosed herein are portable and modular detection devices and systems for detecting electromagnetic radiation, such as fluorescence, from an analyte which comprises at least one optical element removably attached to at least one alignment rail. Also disclosed are modular detection devices and systems having an integrated lock-in amplifier and spatial filter and assay methods using the portable and modular detection devices.

  19. Teaching Acid/Base Physiology in the Laboratory

    Science.gov (United States)

    Friis, Ulla G.; Plovsing, Ronni; Hansen, Klaus; Laursen, Bent G.; Wallstedt, Birgitta

    2010-01-01

    Acid/base homeostasis is one of the most difficult subdisciplines of physiology for medical students to master. A different approach, where theory and practice are linked, might help students develop a deeper understanding of acid/base homeostasis. We therefore set out to develop a laboratory exercise in acid/base physiology that would provide…

  20. Modular Cure Provision

    DEFF Research Database (Denmark)

    Winther-Hansen, Casper; Frandsen, Thomas

    facilitate co-creation through open platforms and service modularity. Based on data from two pharmaceuticals we explore issues of governance related to the relative openness of platforms and their completeness. Whereas some pharmaceuticals should cater to sophisticated needs of competent users through open......Pharmaceuticals increasingly consider the potential of services, as healthcare payers require them to provide data on treatment outcomes. Ranging from corporate websites to free apps, these services are meant to increase the value of product offerings. This paper investigates how services can...

  1. Community vs. Clinic-based modular treatment of children with early-onset ODD or CD: A clinical trial with 3-year follow-up

    OpenAIRE

    Kolko, David J.; Bukstein, Oscar G.; Padini, Dustin; Holden, Elizabeth A.; Hart, Jonathan; Dorn, Lorah D.

    2009-01-01

    This study examines the treatment outcomes of 144, 6–11 year-old, clinically referred boys and girls diagnosed with Oppositional Defiant Disorder (ODD) or Conduct Disorder (CD) who were randomly assigned to a modular-based treatment protocol that was applied by research study clinicians either in the community (COMM) or a clinic office (CLINIC). To examine normative comparisons, a matched sample of 69 healthy control children was included. Multiple informants completed diagnostic interviews a...

  2. A clinical pilot study of a modular video-CT augmentation system for image-guided skull base surgery

    Science.gov (United States)

    Liu, Wen P.; Mirota, Daniel J.; Uneri, Ali; Otake, Yoshito; Hager, Gregory; Reh, Douglas D.; Ishii, Masaru; Gallia, Gary L.; Siewerdsen, Jeffrey H.

    2012-02-01

    Augmentation of endoscopic video with preoperative or intraoperative image data [e.g., planning data and/or anatomical segmentations defined in computed tomography (CT) and magnetic resonance (MR)], can improve navigation, spatial orientation, confidence, and tissue resection in skull base surgery, especially with respect to critical neurovascular structures that may be difficult to visualize in the video scene. This paper presents the engineering and evaluation of a video augmentation system for endoscopic skull base surgery translated to use in a clinical study. Extension of previous research yielded a practical system with a modular design that can be applied to other endoscopic surgeries, including orthopedic, abdominal, and thoracic procedures. A clinical pilot study is underway to assess feasibility and benefit to surgical performance by overlaying CT or MR planning data in realtime, high-definition endoscopic video. Preoperative planning included segmentation of the carotid arteries, optic nerves, and surgical target volume (e.g., tumor). An automated camera calibration process was developed that demonstrates mean re-projection accuracy (0.7+/-0.3) pixels and mean target registration error of (2.3+/-1.5) mm. An IRB-approved clinical study involving fifteen patients undergoing skull base tumor surgery is underway in which each surgery includes the experimental video-CT system deployed in parallel to the standard-of-care (unaugmented) video display. Questionnaires distributed to one neurosurgeon and two otolaryngologists are used to assess primary outcome measures regarding the benefit to surgical confidence in localizing critical structures and targets by means of video overlay during surgical approach, resection, and reconstruction.

  3. Model-based Vestibular Afferent Stimulation: Modular Workflow for Analyzing Stimulation Scenarios in Patient Specific and Statistical Vestibular Anatomy

    Directory of Open Access Journals (Sweden)

    Michael Handler

    2017-12-01

    Full Text Available Our sense of balance and spatial orientation strongly depends on the correct functionality of our vestibular system. Vestibular dysfunction can lead to blurred vision and impaired balance and spatial orientation, causing a significant decrease in quality of life. Recent studies have shown that vestibular implants offer a possible treatment for patients with vestibular dysfunction. The close proximity of the vestibular nerve bundles, the facial nerve and the cochlear nerve poses a major challenge to targeted stimulation of the vestibular system. Modeling the electrical stimulation of the vestibular system allows for an efficient analysis of stimulation scenarios previous to time and cost intensive in vivo experiments. Current models are based on animal data or CAD models of human anatomy. In this work, a (semi-automatic modular workflow is presented for the stepwise transformation of segmented vestibular anatomy data of human vestibular specimens to an electrical model and subsequently analyzed. The steps of this workflow include (i the transformation of labeled datasets to a tetrahedra mesh, (ii nerve fiber anisotropy and fiber computation as a basis for neuron models, (iii inclusion of arbitrary electrode designs, (iv simulation of quasistationary potential distributions, and (v analysis of stimulus waveforms on the stimulation outcome. Results obtained by the workflow based on human datasets and the average shape of a statistical model revealed a high qualitative agreement and a quantitatively comparable range compared to data from literature, respectively. Based on our workflow, a detailed analysis of intra- and extra-labyrinthine electrode configurations with various stimulation waveforms and electrode designs can be performed on patient specific anatomy, making this framework a valuable tool for current optimization questions concerning vestibular implants in humans.

  4. Web-Based Virtual Laboratory for Food Analysis Course

    Science.gov (United States)

    Handayani, M. N.; Khoerunnisa, I.; Sugiarti, Y.

    2018-02-01

    Implementation of learning on food analysis course in Program Study of Agro-industrial Technology Education faced problems. These problems include the availability of space and tools in the laboratory that is not comparable with the number of students also lack of interactive learning tools. On the other hand, the information technology literacy of students is quite high as well the internet network is quite easily accessible on campus. This is a challenge as well as opportunities in the development of learning media that can help optimize learning in the laboratory. This study aims to develop web-based virtual laboratory as one of the alternative learning media in food analysis course. This research is R & D (research and development) which refers to Borg & Gall model. The results showed that assessment’s expert of web-based virtual labs developed, in terms of software engineering aspects; visual communication; material relevance; usefulness and language used, is feasible as learning media. The results of the scaled test and wide-scale test show that students strongly agree with the development of web based virtual laboratory. The response of student to this virtual laboratory was positive. Suggestions from students provided further opportunities for improvement web based virtual laboratory and should be considered for further research.

  5. Web Based Laboratory Task-Submitter Application Model

    Directory of Open Access Journals (Sweden)

    Soetam Rizky Wicaksono

    2010-04-01

    Full Text Available Teaching learning process in laboratory is obligatory in engineering education especially for course in information technology (IT. To make laboratory activities become more interesting for the students, lecturers must build application-based exercise for the student, but after students accomplished their short exercise, it is found that lecturers got difficulty to compile and grade all the exercises. This paper is based on the idea how to overcome the problem above, in order to make activities in the laboratory comfortable for both lectures and student. It is expected that the lectures will able to fully control all practical activity and save the time automatically. To make approach to solve the problem in IT, a modeling process must be conducted first. There for, firstly, this paper explain the model approach for the problem above, then the IT design for practices in laboratory is described. The IT design to overcome the problem has been effectively applied in the real teaching learning process.

  6. ASKI: A modular toolbox for scattering-integral-based seismic full waveform inversion and sensitivity analysis utilizing external forward codes

    Directory of Open Access Journals (Sweden)

    Florian Schumacher

    2016-01-01

    Full Text Available Due to increasing computational resources, the development of new numerically demanding methods and software for imaging Earth’s interior remains of high interest in Earth sciences. Here, we give a description from a user’s and programmer’s perspective of the highly modular, flexible and extendable software package ASKI–Analysis of Sensitivity and Kernel Inversion–recently developed for iterative scattering-integral-based seismic full waveform inversion. In ASKI, the three fundamental steps of solving the seismic forward problem, computing waveform sensitivity kernels and deriving a model update are solved by independent software programs that interact via file output/input only. Furthermore, the spatial discretizations of the model space used for solving the seismic forward problem and for deriving model updates, respectively, are kept completely independent. For this reason, ASKI does not contain a specific forward solver but instead provides a general interface to established community wave propagation codes. Moreover, the third fundamental step of deriving a model update can be repeated at relatively low costs applying different kinds of model regularization or re-selecting/weighting the inverted dataset without need to re-solve the forward problem or re-compute the kernels. Additionally, ASKI offers the user sensitivity and resolution analysis tools based on the full sensitivity matrix and allows to compose customized workflows in a consistent computational environment. ASKI is written in modern Fortran and Python, it is well documented and freely available under terms of the GNU General Public License (http://www.rub.de/aski.

  7. A modular, energy-based approach to the development of nickel containing molecular electrocatalysts for hydrogen production and oxidation.

    Science.gov (United States)

    Shaw, Wendy J; Helm, Monte L; DuBois, Daniel L

    2013-01-01

    This review discusses the development of molecular electrocatalysts for H2 production and oxidation based on nickel. A modular approach is used in which the structure of the catalyst is divided into first, second, and outer coordination spheres. The first coordination sphere consists of the ligands bound directly to the metal center, and this coordination sphere can be used to control such factors as the presence or absence of vacant coordination sites, redox potentials, hydride donor abilities and other important thermodynamic parameters. The second coordination sphere includes functional groups such as pendent acids or bases that can interact with bound substrates such as H2 molecules and hydride ligands, but that do not form strong bonds with the metal center. These functional groups can play diverse roles such as assisting the heterolytic cleavage of H2, controlling intra- and intermolecular proton transfer reactions, and providing a physical pathway for coupling proton and electron transfer reactions. By controlling both the hydride donor ability of the catalysts using the first coordination sphere and the proton donor abilities of the functional groups in the second coordination sphere, catalysts can be designed that are biased toward H2 production, oxidation, or bidirectional (catalyzing both H2 oxidation and production). The outer coordination sphere is defined as that portion of the catalytic system that is beyond the second coordination sphere. This coordination sphere can assist in the delivery of protons and electrons to and from the catalytically active site, thereby adding another important avenue for controlling catalytic activity. Many features of these simple catalytic systems are good models for enzymes, and these simple systems provide insights into enzyme function and reactivity that may be difficult to probe in enzymes. This article is part of a Special Issue entitled: Metals in Bioenergetics and Biomimetics Systems. Copyright © 2013 Elsevier

  8. Modular Multilevel Converters Based Variable Speed Wind Turbines for Grid Faults

    DEFF Research Database (Denmark)

    Deng, Fujin; Liu, Dong; Wang, Yanbo

    2016-01-01

    in the dc-link of the power converter to improve system performance, but also ensure the grid-side current balancing to increase the generated power of the wind turbine under the unbalanced grid fault, in comparison with the conventional VSWT based on BTB three-level NPC converters. The simulation studies...

  9. Teaching acid/base physiology in the laboratory

    DEFF Research Database (Denmark)

    Friis, Ulla G; Plovsing, Ronni; Hansen, Klaus

    2010-01-01

    Acid/base homeostasis is one of the most difficult subdisciplines of physiology for medical students to master. A different approach, where theory and practice are linked, might help students develop a deeper understanding of acid/base homeostasis. We therefore set out to develop a laboratory...... exercise in acid/base physiology that would provide students with unambiguous and reproducible data that clearly would illustrate the theory in practice. The laboratory exercise was developed to include both metabolic acidosis and respiratory alkalosis. Data were collected from 56 groups of medical...

  10. A modularized electronic payment system for agent-based e-commerce

    OpenAIRE

    Guan, SU; Tan, SL; Hua, F

    2004-01-01

    With the explosive growth of the Internet, electronic-commerce (e-commerce) is an increasingly important segment of commercial activities on the web. The Secure Agent Fabrication, Evolution & Roaming (SAFER) architecture was proposed to further facilitate e-commerce using agent technology. In this paper, the electronic payment aspect of SAFER will be explored. The Secure Electronic Transaction (SET) protocol and E-Cash were selected as the bases for the electronic payment system implementatio...

  11. RoboMusic with modular playware

    DEFF Research Database (Denmark)

    Falkenberg, Kasper; Bærendsen, Niels Kristian; Nielsen, Jacob

    2011-01-01

    , immediate feedback to stimulate engagement, creative exploration of play activities, and in some cases activity design by end-users (e.g., DJs). We exemplify the approach with the development of 11 rock genres and 6 pop music pieces for modular I-BLOCKS, which are exhibited and in daily use at the Rock Me......Based on the concepts of RoboMusic and modular playware, we developed a system composed of modular playware devices which allow any user to perform music in a simple, interactive manner. The key features exploited in the modular playware approach are modularity, fl exibility, construction...... exhibition, and have been used at several international music events in Japan and the USA. A key fi nding is that professional music design is essential for the development of primitives in a musical behavior-based system, and this professional esthetics is necessary to engage the users in the activity...

  12. A modular and adaptive mass spectrometry-based platform for support of bioprocess development toward optimal host cell protein clearance

    Science.gov (United States)

    Yang, Feng; Carver, Joseph; Joe, Koman; Michels, David A.

    2017-01-01

    ABSTRACT A modular and adaptive mass spectrometry (MS)-based platform was developed to provide fast, robust and sensitive host cell protein (HCP) analytics to support process development. This platform relies on one-dimensional ultra-high performance liquid chromatography (1D UHPLC) combined with several different MS data acquisition strategies to meet the needs of purification process development. The workflow was designed to allow HCP composition and quantitation for up to 20 samples per day, a throughput considered essential for real time bioprocess development support. With data-dependent acquisition (DDA), the 1D UHPLC-MS/MS method had excellent speed and demonstrated robustness in detecting unknown HCPs at ≥ 50 ng/mg (ppm) level. Combining 1D UHPLC with sequential window acquisition of all theoretical spectra (SWATH) MS enabled simultaneous detection and quantitation of all HCPs in single-digit ng/mg range within 1 hour, demonstrating for the first time the benefit of SWATH MS as a technique for HCP analysis. As another alternative, a targeted MS approach can be used to track the clearance of specific known HCP under various process conditions. This study highlights the importance of designing a robust LC-MS/MS workflow that not only allows HCP discovery, but also affords greatly improved process knowledge and capability in HCP removal. As an orthogonal and complementary detection approach to traditional HCP analysis by enzyme-linked immunosorbent assay, the reported LC-MS/MS workflow supports the development of bioprocesses with optimal HCP clearance and the production of safe and high quality therapeutic biopharmaceuticals. PMID:28346045

  13. M3BA: A Mobile, Modular, Multimodal Biosignal Acquisition Architecture for Miniaturized EEG-NIRS-Based Hybrid BCI and Monitoring.

    Science.gov (United States)

    von Luhmann, Alexander; Wabnitz, Heidrun; Sander, Tilmann; Muller, Klaus-Robert

    2017-06-01

    For the further development of the fields of telemedicine, neurotechnology, and brain-computer interfaces, advances in hybrid multimodal signal acquisition and processing technology are invaluable. Currently, there are no commonly available hybrid devices combining bioelectrical and biooptical neurophysiological measurements [here electroencephalography (EEG) and functional near-infrared spectroscopy (NIRS)]. Our objective was to design such an instrument in a miniaturized, customizable, and wireless form. We present here the design and evaluation of a mobile, modular, multimodal biosignal acquisition architecture (M3BA) based on a high-performance analog front-end optimized for biopotential acquisition, a microcontroller, and our openNIRS technology. The designed M3BA modules are very small configurable high-precision and low-noise modules (EEG input referred noise @ 500 SPS 1.39 μV pp , NIRS noise equivalent power NEP 750 nm = 5.92 pW pp , and NEP 850 nm = 4.77 pW pp ) with full input linearity, Bluetooth, 3-D accelerometer, and low power consumption. They support flexible user-specified biopotential reference setups and wireless body area/sensor network scenarios. Performance characterization and in-vivo experiments confirmed functionality and quality of the designed architecture. Telemedicine and assistive neurotechnology scenarios will increasingly include wearable multimodal sensors in the future. The M3BA architecture can significantly facilitate future designs for research in these and other fields that rely on customized mobile hybrid biosignal modal biosignal acquisition architecture (M3BA), multimodal, near-infrared spectroscopy (NIRS), wireless body area network (WBAN), wireless body sensor network (WBSN).

  14. A Modular GIS-Based Software Architecture for Model Parameter Estimation using the Method of Anchored Distributions (MAD)

    Science.gov (United States)

    Ames, D. P.; Osorio-Murillo, C.; Over, M. W.; Rubin, Y.

    2012-12-01

    The Method of Anchored Distributions (MAD) is an inverse modeling technique that is well-suited for estimation of spatially varying parameter fields using limited observations and Bayesian methods. This presentation will discuss the design, development, and testing of a free software implementation of the MAD technique using the open source DotSpatial geographic information system (GIS) framework, R statistical software, and the MODFLOW groundwater model. This new tool, dubbed MAD-GIS, is built using a modular architecture that supports the integration of external analytical tools and models for key computational processes including a forward model (e.g. MODFLOW, HYDRUS) and geostatistical analysis (e.g. R, GSLIB). The GIS-based graphical user interface provides a relatively simple way for new users of the technique to prepare the spatial domain, to identify observation and anchor points, to perform the MAD analysis using a selected forward model, and to view results. MAD-GIS uses the Managed Extensibility Framework (MEF) provided by the Microsoft .NET programming platform to support integration of different modeling and analytical tools at run-time through a custom "driver." Each driver establishes a connection with external programs through a programming interface, which provides the elements for communicating with core MAD software. This presentation gives an example of adapting the MODFLOW to serve as the external forward model in MAD-GIS for inferring the distribution functions of key MODFLOW parameters. Additional drivers for other models are being developed and it is expected that the open source nature of the project will engender the development of additional model drivers by 3rd party scientists.

  15. Remote Laboratory Java Server Based on JACOB Project

    Directory of Open Access Journals (Sweden)

    Pavol Bisták

    2011-02-01

    Full Text Available Remote laboratories play an important role in the educational process of engineers. This paper deals with the structure of remote laboratories. The principle of the proposed remote laboratory structure is based on the Java server application that communicates with Matlab through the COM technology for the data exchange under the Windows operating system. Java does not support COM directly so the results of the JACOB project are used and modified to cope with this problem. In laboratories for control engineering education a control algorithm usually runs on a PC with Matlab that really controls the real plant. This is the server side described in the paper in details. To demonstrate the possibilities of a remote control a Java client server application is also introduced. It covers communication and offers a user friendly interface for the control of a remote plant and visualization of measured data.

  16. Physical Modeling Modular Boxes: PHOXES

    DEFF Research Database (Denmark)

    Gelineck, Steven; Serafin, Stefania

    2010-01-01

    This paper presents the development of a set of musical instruments, which are based on known physical modeling sound synthesis techniques. The instruments are modular, meaning that they can be combined in various ways. This makes it possible to experiment with physical interaction and sonic...

  17. Modular ICT-based patient empowerment framework for self-management of diabetes: Design perspectives and validation results.

    Science.gov (United States)

    Lamprinos, Ilias; Demski, Hans; Mantwill, Sarah; Kabak, Yildiray; Hildebrand, Claudia; Ploessnig, Manuela

    2016-07-01

    It is estimated that more than 382 million people suffer from diabetes across the globe, most of which are between the age of 40 and 59 years. ICT can play a key role in better management of diabetes and in patient empowerment. Patient empowerment involves patients to a greater extent in their own healthcare process and disease management becomes an integrated part of their daily life. Self-management opens the possibility for patients to contribute to their own healthcare as well as to be more in control of their disease. The objective of our study was to explore the impact of an ICT-based patient empowerment framework in diabetes self-management. A modular patient empowerment framework that fosters diabetes self-management was designed and implemented. The framework incorporates expert knowledge in the form of clinical guidelines, and it supports patients in the specification of personalized activities that are based on medical recommendations and personal goals, and in the collection of observations of daily living. The usability and usefulness of the proposed framework were assessed in a pilot study with the participation of 60 patients and 12 health professionals. The study revealed that a patient empowerment approach based on self-management ICT tools is useful and accepted by both the patients and the physicians. For those patients who were already disciplined in their disease management the piloted solution served as a facilitator for data logging. For the rest, it served as an incentive for better adherence to disease management principles. The ICT tools prompted many patients into becoming more physically active and into making dietary habits' adjustments. However, this impact proved to be tightly correlated with the sociocultural background of the subjects. The study also demonstrated that even in patient-centric self-management interventions the physicians still have a key role to play. However, the acceptance of such interventions by the healthcare

  18. RoboMusic with Modular Playware

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop; Bærendsen, Niels Kristian; Nielsen, Jacob

    2010-01-01

    , immediate feedback to stimulate engagement, creative exploration of play activities, and in some cases activity design by end-users (e.g. DJ’s). We exemplify the approach with the development of 11 rock genres and 6 pop music pieces for modular I-BLOCKS, which are exhibited and in daily use at the Rock Me......Based on the concepts of RoboMusic and Modular Playware, we developed a system composed of modular playware devices, which allow any user to perform music in a simple, interactive manner. The key features exploited from the Modular Playware approach are modularity, flexibility, and construction...... exhibition and used at several international music events in Japan and USA. A key finding is that the professional music design is essential for the development of primitives in a musical behaviourbased system and this professional aesthetics is necessary for engaging the users in the activity of assembling...

  19. Designing Modular Robotic Playware

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop; Marti, Patrizia

    2009-01-01

    In this paper, we explore the design of modular robotic objects that may enhance playful experiences. The approach builds upon the development of modular robotics to create a kind of playware, which is flexible in both set-up and activity building for the end-user to allow easy creation of games...... robotic tiles, and discusses the challenges and opportunities of this modular playware when used by children with different cognitive abilities....

  20. Modular Robotic Wearable

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop; Pagliarini, Luigi

    2009-01-01

    In this concept paper we trace the contours and define a new approach to robotic systems, composed of interactive robotic modules which are somehow worn on the body. We label such a field as Modular Robotic Wearable (MRW). We describe how, by using modular robotics for creating wearable....... Finally, by focusing on the intersection of the combination modular robotic systems, wearability, and bodymind we attempt to explore the theoretical characteristics of such approach and exploit the possible playware application fields....

  1. The Impact of Product and Service Modularity on Business Performance

    DEFF Research Database (Denmark)

    Hsuan, Juliana; Frandsen, Thomas; Raja, Jawwad

    Modularity has been proposed as a powerful way of managing complexity. The emerging literature points to the importance of modularity of service architecture, with case based studies in logistics and healthcare. Little is known about the relationship between product and service modularity...... and their effects on business performance, both empirically and theoretically. This paper explores the relationship between product and service modularity and their effects on business performance based on a survey of Danish manufacturers. We provide empirical and theoretical insights into the emerging fields...... of service modularity and industrial services....

  2. Integrating Interdisciplinary Research-Based Experiences in Biotechnology Laboratories

    Science.gov (United States)

    Iyer, Rupa S.; Wales, Melinda E.

    2012-01-01

    The increasingly interdisciplinary nature of today's scientific research is leading to the transformation of undergraduate education. In addressing these needs, the University of Houston's College of Technology has developed a new interdisciplinary research-based biotechnology laboratory curriculum. Using the pesticide degrading bacterium,…

  3. An Inquiry-Based Density Laboratory for Teaching Experimental Error

    Science.gov (United States)

    Prilliman, Stephen G.

    2012-01-01

    An inquiry-based laboratory exercise is described in which introductory chemistry students measure the density of water five times using either a beaker, a graduated cylinder, or a volumetric pipet. Students are also assigned to use one of two analytical balances, one of which is purposefully miscalibrated by 5%. Each group collects data using…

  4. Community-Based Presentations in the Unit Operations Laboratory

    Science.gov (United States)

    Mitchell, Brian S.; Law, Victor J.

    2005-01-01

    A method for incorporating community­-based oral presentations into the undergraduate chemical engineering unit operations laboratory experience is described. Examples are given of appropriate topics and how these presentations can be incorporated into the experiment sequence. Course evaluations reflect the fact that these presentations are an…

  5. A modular toolbox for gRNA?Cas9 genome engineering in plants based on the GoldenBraid standard

    OpenAIRE

    Vazquez-Vilar, Marta; Bernab?-Orts, Joan Miquel; Fernandez-del-Carmen, Asun; Ziarsolo, Pello; Blanca, Jose; Granell, Antonio; Orzaez, Diego

    2016-01-01

    [EN] Background: The efficiency, versatility and multiplexing capacity of RNA-guided genome engineering using the CRISPR/Cas9 technology enables a variety of applications in plants, ranging from gene editing to the construction of transcriptional gene circuits, many of which depend on the technical ability to compose and transfer complex synthetic instructions into the plant cell. The engineering principles of standardization and modularity applied to DNA cloning are impacting pla...

  6. Optimizing Safety Stock Levels in Modular Production Systems Using Component Commonality and Group Technology Philosophy: A Study Based on Simulation

    Directory of Open Access Journals (Sweden)

    Kenneth Edgar Hernandez-Ruiz

    2016-01-01

    Full Text Available Modular production and component commonality are two widely used strategies in the manufacturing industry to meet customers growing needs for customized products. Using these strategies, companies can enhance their performance to achieve optimal safety stock levels. Despite the importance of safety stocks in business competition, little attention has been paid to the way to reduce them without affecting the customer service levels. This paper develops a mathematical model to reduce safety stock levels in organizations that employ modular production. To construct the model, we take advantage of the benefits of aggregate inventories, standardization of components, component commonality, and Group Technology philosophy in regard to stock levels. The model is tested through the simulation of three years of operation of two modular product systems. For each system, we calculated and compared the safety stock levels for two cases: (1 under the only presence of component commonality and (2 under the presence of both component commonality and Group Technology philosophy. The results show a reduction in safety stock levels when we linked the component commonality with the Group Technology philosophy. The paper presents a discussion of the implications of each case, features of the model, and suggestions for future research.

  7. Directed energy deflection laboratory measurements of common space based targets

    Science.gov (United States)

    Brashears, Travis; Lubin, Philip; Hughes, Gary B.; Meinhold, Peter; Batliner, Payton; Motta, Caio; Madajian, Jonathan; Mercer, Whitaker; Knowles, Patrick

    2016-09-01

    We report on laboratory studies of the effectiveness of directed energy planetary defense as a part of the DE-STAR (Directed Energy System for Targeting of Asteroids and exploRation) program. DE-STAR and DE-STARLITE are directed energy "stand-off" and "stand-on" programs, respectively. These systems consist of a modular array of kilowatt-class lasers powered by photovoltaics, and are capable of heating a spot on the surface of an asteroid to the point of vaporization. Mass ejection, as a plume of evaporated material, creates a reactionary thrust capable of diverting the asteroid's orbit. In a series of papers, we have developed a theoretical basis and described numerical simulations for determining the thrust produced by material evaporating from the surface of an asteroid. In the DESTAR concept, the asteroid itself is used as the deflection "propellant". This study presents results of experiments designed to measure the thrust created by evaporation from a laser directed energy spot. We constructed a vacuum chamber to simulate space conditions, and installed a torsion balance that holds a common space target sample. The sample is illuminated with a fiber array laser with flux levels up to 60 MW/m2 , which allows us to simulate a mission level flux but on a small scale. We use a separate laser as well as a position sensitive centroid detector to readout the angular motion of the torsion balance and can thus determine the thrust. We compare the measured thrust to the models. Our theoretical models indicate a coupling coefficient well in excess of 100 μN/Woptical, though we assume a more conservative value of 80 μN/Woptical and then degrade this with an optical "encircled energy" efficiency of 0.75 to 60 μN/Woptical in our deflection modeling. Our measurements discussed here yield about 45 μN/Wabsorbed as a reasonable lower limit to the thrust per optical watt absorbed. Results vary depending on the material tested and are limited to measurements of 1 axis, so

  8. Temperature Sensing in Modular Microfluidic Architectures

    Directory of Open Access Journals (Sweden)

    Krisna C. Bhargava

    2016-01-01

    Full Text Available A discrete microfluidic element with integrated thermal sensor was fabricated and demonstrated as an effective probe for process monitoring and prototyping. Elements were constructed using stereolithography and market-available glass-bodied thermistors within the modular, standardized framework of previous discrete microfluidic elements demonstrated in the literature. Flow rate-dependent response due to sensor self-heating and microchannel heating and cooling was characterized and shown to be linear in typical laboratory conditions. An acid-base neutralization reaction was performed in a continuous flow setting to demonstrate applicability in process management: the ratio of solution flow rates was varied to locate the equivalence point in a titration, closely matching expected results. This element potentially enables complex, three-dimensional microfluidic architectures with real-time temperature feedback and flow rate sensing, without application specificity or restriction to planar channel routing formats.

  9. Development of a Modular Robotic Platform

    Directory of Open Access Journals (Sweden)

    Claudiu Ioan Cirebea

    2014-12-01

    Full Text Available In this paper a modular robotic platform is presented, for students and researchers laboratory work based on the Matlab-Simulink and dSpace real time control platform. The goal of this combination is to stimulate and to experiment with real time hardware and software in courses where mobile robotics is adopted as a motivating platform to introduce mechatronics competencies. Its many possibilities for modifications and extensions make experiments very easy. We used, for example, an omnidirectional mobile robot configuration with three Swedish wheels, whose kinematic model was simulated using Simulink. For real-time control, of the robot, the developed model has been implemented using DSpace platform DS1103.

  10. Introduction of an agent-based multi-scale modular architecture for dynamic knowledge representation of acute inflammation

    Directory of Open Access Journals (Sweden)

    An Gary

    2008-05-01

    Full Text Available Abstract Background One of the greatest challenges facing biomedical research is the integration and sharing of vast amounts of information, not only for individual researchers, but also for the community at large. Agent Based Modeling (ABM can provide a means of addressing this challenge via a unifying translational architecture for dynamic knowledge representation. This paper presents a series of linked ABMs representing multiple levels of biological organization. They are intended to translate the knowledge derived from in vitro models of acute inflammation to clinically relevant phenomenon such as multiple organ failure. Results and Discussion ABM development followed a sequence starting with relatively direct translation from in-vitro derived rules into a cell-as-agent level ABM, leading on to concatenated ABMs into multi-tissue models, eventually resulting in topologically linked aggregate multi-tissue ABMs modeling organ-organ crosstalk. As an underlying design principle organs were considered to be functionally composed of an epithelial surface, which determined organ integrity, and an endothelial/blood interface, representing the reaction surface for the initiation and propagation of inflammation. The development of the epithelial ABM derived from an in-vitro model of gut epithelial permeability is described. Next, the epithelial ABM was concatenated with the endothelial/inflammatory cell ABM to produce an organ model of the gut. This model was validated against in-vivo models of the inflammatory response of the gut to ischemia. Finally, the gut ABM was linked to a similarly constructed pulmonary ABM to simulate the gut-pulmonary axis in the pathogenesis of multiple organ failure. The behavior of this model was validated against in-vivo and clinical observations on the cross-talk between these two organ systems Conclusion A series of ABMs are presented extending from the level of intracellular mechanism to clinically observed behavior

  11. A modular, low-cost, digital signal processor-based lock-in card for measuring optical attenuation

    Science.gov (United States)

    Barragán, L. A.; Artigas, J. I.; Alonso, R.; Villuendas, F.

    2001-01-01

    A modular, low-cost, digital signal processor (DSP)-based lock-in card is described for measuring optical attenuation. By transferring the lock-in operation from the analog domain to the digital domain, the nonlinearities gain, and offset errors and drifts are virtually eliminated. The dual phase lock-in operation has been implemented on the low-cost DSP56002 evaluation module (DSP56002EVM) of Motorola that is widely used in audio signal processing. This evaluation board contains a 24 bit DSP56002 DSP and a stereo CD-quality audio codec that makes the board ideal for implementing signal processing algorithms. Due to the maximum sampling rate of the codec embedded on the DSP56002EVM, the frequencies of the processed signals must be below 20 kHz. This specification is enough for the most common applications in the field of optics, where low or very low frequency (<1 kHz) references are frequent. The software algorithm implementing the lock-in amplifier can be particularized by the user on the basis of the needed performances. The effects of finite word length in the digital filter implementation are analyzed. This analysis reveals that a 24 bit word length is not enough to ensure the filter stability and the required frequency response. To overcome this problem, the double precision multiply mode must be used. When the DSP56002 enters this mode, double precision 48 bit by 48 bit multiplication can be performed. The lock-in performance has been tested. The measured amplitude variations of the reference sine signal are about 0.003%, which do not affect the signal measurement. The lock-in behaves like a band-pass filter centered on the reference frequency whose bandwidth is related to the low-pass filter cutoff frequency. The measured frequency response shows that the lock-in performs as theoretically predicted. The DSP56002EVM can be used as a lock-in for electrical signals in stand-alone operation. Besides, we have designed a card that interconnects to the DSP56002EVM

  12. E-laboratories : agent-based modeling of electricity markets.

    Energy Technology Data Exchange (ETDEWEB)

    North, M.; Conzelmann, G.; Koritarov, V.; Macal, C.; Thimmapuram, P.; Veselka, T.

    2002-05-03

    Electricity markets are complex adaptive systems that operate under a wide range of rules that span a variety of time scales. These rules are imposed both from above by society and below by physics. Many electricity markets are undergoing or are about to undergo a transition from centrally regulated systems to decentralized markets. Furthermore, several electricity markets have recently undergone this transition with extremely unsatisfactory results, most notably in California. These high stakes transitions require the introduction of largely untested regulatory structures. Suitable laboratories that can be used to test regulatory structures before they are applied to real systems are needed. Agent-based models can provide such electronic laboratories or ''e-laboratories.'' To better understand the requirements of an electricity market e-laboratory, a live electricity market simulation was created. This experience helped to shape the development of the Electricity Market Complex Adaptive Systems (EMCAS) model. To explore EMCAS' potential as an e-laboratory, several variations of the live simulation were created. These variations probed the possible effects of changing power plant outages and price setting rules on electricity market prices.

  13. Mixed Reality Environment for Web-Based Laboratory Interactive Learning

    Directory of Open Access Journals (Sweden)

    A. I. Saleem

    2008-02-01

    Full Text Available This paper presents a web-based laboratory fordistance learners by incorporating simulation andhardware implementation into web-based e-learningsystems. It presents a development consisting of laboratorycourse through internet based on mixed reality technique tosetup, run and manipulateset of experiments. Eachexperiment has been designed in a way that allows thelearner to manipulate the components and check if it worksproperly in order to achieve the experiment objective. Theproposed laboratory e-learning tool has web-basedcomponents accessed by authorized users. Learners canacquire the necessary skills they need, while learning thetheory of the experiment and the basic characteristics ofeach component used in the experiment. Finally, a casestudy was conducted to show the feasibility and efficiencyof the proposed method.

  14. Modular Forms and Weierstrass Mock Modular Forms

    Directory of Open Access Journals (Sweden)

    Amanda Clemm

    2016-02-01

    Full Text Available Alfes, Griffin, Ono, and Rolen have shown that the harmonic Maass forms arising from Weierstrass ζ-functions associated to modular elliptic curves “encode” the vanishing and nonvanishing for central values and derivatives of twisted Hasse-Weil L-functions for elliptic curves. Previously, Martin and Ono proved that there are exactly five weight 2 newforms with complex multiplication that are eta-quotients. In this paper, we construct a canonical harmonic Maass form for these five curves with complex multiplication. The holomorphic part of this harmonic Maass form arises from the Weierstrass ζ-function and is referred to as the Weierstrass mock modular form. We prove that the Weierstrass mock modular form for these five curves is itself an eta-quotient or a twist of one. Using this construction, we also obtain p-adic formulas for the corresponding weight 2 newform using Atkin’s U-operator.

  15. Learning Modular Policies for Robotics

    Directory of Open Access Journals (Sweden)

    Gerhard eNeumann

    2014-06-01

    Full Text Available A promising idea for scaling robot learning to more complex tasks is to use elemental behaviors as building blocks to compose more complex behaviour. Ideally, such building blocks are used in combination with a learning algorithmthat is able to learn to select, adapt, sequence and co-activate the building blocks. While there has been a lot of work on approaches that support one of theserequirements, no learning algorithm exists that unifies all these properties in one framework.%Adaptation of the parameter vector is needed to reuse the elemental behaviours for more than one situation. %Second, the learning architecture needs to learn to select between and to sequence such parametrized building blocks. Finally,%the expressibility of a modular control architecture can be drastically increased if the architecture supports co-activate the single building blocks.%In this paper we give an overview of our work on learning such a modular control architecture. In this paper we present our work on a unified approach for learning such a modular control architecture. We introduce new policy search algorithmsthat are based on information-theoretic principles and are able to learn to select, adapt and sequence the building blocks. Furthermore, we developed a new representation for the individual building block that support co-activation and principled ways for adapting the movement. Finally, we summarize our experiments for learning modular control architectures in simulation and with real robots.

  16. Sub-module Short Circuit Fault Diagnosis in Modular Multilevel Converter Based on Wavelet Transform and Adaptive Neuro Fuzzy Inference System

    DEFF Research Database (Denmark)

    Liu, Hui; Loh, Poh Chiang; Blaabjerg, Frede

    2015-01-01

    by employing wavelet transform under different fault conditions. Then the fuzzy logic rules are automatically trained based on the fuzzified fault features to diagnose the different faults. Neither additional sensor nor the capacitor voltages are needed in the proposed method. The high accuracy, good...... for continuous operation and post-fault maintenance. In this article, a fault diagnosis technique is proposed for the short circuit fault in a modular multi-level converter sub-module using the wavelet transform and adaptive neuro fuzzy inference system. The fault features are extracted from output phase voltage...

  17. Modular tree automata

    DEFF Research Database (Denmark)

    Bahr, Patrick

    2012-01-01

    Tree automata are traditionally used to study properties of tree languages and tree transformations. In this paper, we consider tree automata as the basis for modular and extensible recursion schemes. We show, using well-known techniques, how to derive from standard tree automata highly modular r...

  18. Exploring Modularity in Services

    DEFF Research Database (Denmark)

    Avlonitis, Viktor; Hsuan, Juliana

    2017-01-01

    insights on the mirroring hypothesis of modularity theory to services. Originality/value The paper provides a conceptualization of service architectures drawing on service design, modularity, and market relationships. The study enriches service design literature with elements from modularity theory......Purpose The purpose of this paper is to examine how modularity manifests in the design of services. The study brings new insights on the organization of service firms by empirically exploring and theoretically advancing the intersection of modularity and service design. Design....../methodology/approach The paper compares two companies that offer similar services in the same geographical region but represent polar case types. A framework grounded on extant literature is constructed and applied to the two cases to assess its practicality and provide theoretical insights. Findings The paper demonstrates...

  19. Laboratory test of an APS-based sun sensor prototype

    Science.gov (United States)

    Rufino, Giancarlo; Perrotta, Alessandro; Grassi, Michele

    2017-11-01

    This paper deals with design and prototype development of an Active Pixel Sensor - based miniature sun sensor and a laboratory facility for its indoor test and calibration. The miniature sun sensor is described and the laboratory test facility is presented in detail. The major focus of the paper is on tests and calibration of the sensor. Two different calibration functions have been adopted. They are based, respectively, on a geometrical model, which has required least-squares optimisation of system physical parameters estimates, and on neural networks. Calibration results are presented for the above solutions, showing that accuracy in the order of 0.01° has been achieved. Neural calibration functions have attained better performance thanks to their intrinsic auto-adaptive structure.

  20. Modular weapon control unit

    Energy Technology Data Exchange (ETDEWEB)

    Boccabella, M.F.; McGovney, G.N.

    1997-01-01

    The goal of the Modular Weapon Control Unit (MWCU) program was to design and develop a reconfigurable weapon controller (programmer/sequencer) that can be adapted to different weapon systems based on the particular requirements for that system. Programmers from previous systems are conceptually the same and perform similar tasks. Because of this commonality and the amount of re-engineering necessary with the advent of every new design, the idea of a modular, adaptable system has emerged. Also, the controller can be used in more than one application for a specific weapon system. Functionality has been divided into a Processor Module (PM) and an Input/Output Module (IOM). The PM will handle all operations that require calculations, memory, and timing. The IOM will handle interfaces to the rest of the system, input level shifting, output drive capability, and detection of interrupt conditions. Configuration flexibility is achieved in two ways. First, the operation of the PM is determined by a surface mount Read-Only Memory (ROM). Other surface-mount components can be added or neglected as necessary for functionality. Second, IOMs consist of configurable input buffers, configurable output drivers, and configurable interrupt generation. Further, these modules can be added singly or in groups to a Processor Module to achieve the required I/O configuration. The culmination of this LDRD was the building of both Processor Module and Input/Output Module. The MWCU was chosen as a test system to evaluate Low-Temperature Co-fired Ceramic (LTCC) technology, desirable for high component density and good thermal characteristics.

  1. Rapid data processing for ultrafast X-ray computed tomography using scalable and modular CUDA based pipelines

    Science.gov (United States)

    Frust, Tobias; Wagner, Michael; Stephan, Jan; Juckeland, Guido; Bieberle, André

    2017-10-01

    Ultrafast X-ray tomography is an advanced imaging technique for the study of dynamic processes basing on the principles of electron beam scanning. A typical application case for this technique is e.g. the study of multiphase flows, that is, flows of mixtures of substances such as gas-liquidflows in pipelines or chemical reactors. At Helmholtz-Zentrum Dresden-Rossendorf (HZDR) a number of such tomography scanners are operated. Currently, there are two main points limiting their application in some fields. First, after each CT scan sequence the data of the radiation detector must be downloaded from the scanner to a data processing machine. Second, the current data processing is comparably time-consuming compared to the CT scan sequence interval. To enable online observations or use this technique to control actuators in real-time, a modular and scalable data processing tool has been developed, consisting of user-definable stages working independently together in a so called data processing pipeline, that keeps up with the CT scanner's maximal frame rate of up to 8 kHz. The newly developed data processing stages are freely programmable and combinable. In order to achieve the highest processing performance all relevant data processing steps, which are required for a standard slice image reconstruction, were individually implemented in separate stages using Graphics Processing Units (GPUs) and NVIDIA's CUDA programming language. Data processing performance tests on different high-end GPUs (Tesla K20c, GeForce GTX 1080, Tesla P100) showed excellent performance. Program Files doi:http://dx.doi.org/10.17632/65sx747rvm.1 Licensing provisions: LGPLv3 Programming language: C++/CUDA Supplementary material: Test data set, used for the performance analysis. Nature of problem: Ultrafast computed tomography is performed with a scan rate of up to 8 kHz. To obtain cross-sectional images from projection data computer-based image reconstruction algorithms must be applied. The

  2. Size reduction of complex networks preserving modularity

    International Nuclear Information System (INIS)

    Arenas, A; Duch, J; Fernandez, A; Gomez, S

    2007-01-01

    The ubiquity of modular structure in real-world complex networks is the focus of attention in many trials to understand the interplay between network topology and functionality. The best approaches to the identification of modular structure are based on the optimization of a quality function known as modularity. However this optimization is a hard task provided that the computational complexity of the problem is in the non-deterministic polynomial-time hard (NP-hard) class. Here we propose an exact method for reducing the size of weighted (directed and undirected) complex networks while maintaining their modularity. This size reduction allows use of heuristic algorithms that optimize modularity for a better exploration of the modularity landscape. We compare the modularity obtained in several real complex-networks by using the extremal optimization algorithm, before and after the size reduction, showing the improvement obtained. We speculate that the proposed analytical size reduction could be extended to an exact coarse graining of the network in the scope of real-space renormalization

  3. Reactive power compensation capability of a STATCOM based on two types of Modular Multilevel Cascade Converters for offshore wind application

    DEFF Research Database (Denmark)

    Tanaka, Takaaki; Wang, Huai; Ma, Ke

    2017-01-01

    Static Synchronous Compensators (STATCOMs) have been applied for offshore wind power plants to satisfy the grid codes under both normal operation and grid fault conditions. This paper investigates the performances of two types of Modular Multilevel Cascade Converters (MMCC) for STATCOM applications......, with the special focus on asymmetrical Low-Voltage-Ride-Through (LVRT) operation under grid faults. The design of an 80 MVar / 33 kV STATCOM is first presented. The electro-thermal stress of the power modules used in each type of MMCC is analyzed with voltage balancing control under grid faults. Finally...

  4. A predictive model of muscle excitations based on muscle modularity for a large repertoire of human locomotion conditions

    Directory of Open Access Journals (Sweden)

    Jose eGonzalez-Vargas

    2015-09-01

    Full Text Available Humans can efficiently walk across a large variety of terrains and locomotion conditions with little or no mental effort. It has been hypothesized that the nervous system simplifies neuromuscular control by using muscle synergies, thus organizing multi-muscle activity into a small number of coordinative co-activation modules. In the present study we investigated how muscle modularity is structured across a large repertoire of locomotion conditions including five different speeds and five different ground elevations. For this we have used the non-negative matrix factorization technique in order to explain EMG experimental data with a low-dimensional set of four motor components. In this context each motor components is composed of a non-negative factor and the associated muscle weightings. Furthermore, we have investigated if the proposed descriptive analysis of muscle modularity could be translated into a predictive model that could: 1 Estimate how motor components modulate across locomotion speeds and ground elevations. This implies not only estimating the non-negative factors temporal characteristics, but also the associated muscle weighting variations. 2 Estimate how the resulting muscle excitations modulate across novel locomotion conditions and subjects.The results showed three major distinctive features of muscle modularity: 1 the number of motor components was preserved across all locomotion conditions, 2 the non-negative factors were consistent in shape and timing across all locomotion conditions, and 3 the muscle weightings were modulated as distinctive functions of locomotion speed and ground elevation. Results also showed that the developed predictive model was able to reproduce well the muscle modularity of un-modeled data, i.e. novel subjects and conditions. Muscle weightings were reconstructed with a cross-correlation factor greater than 70% and a root mean square error less than 0.10. Furthermore, the generated muscle excitations

  5. Modular Product Families and Assembly Systems

    DEFF Research Database (Denmark)

    Thyssen, Jesper

    2005-01-01

    of the rela-tionship between variables associated with configuration of modular product families and the interacting assembly system. One core result is the development of a system model based on the longitudinal case study incorporating both structural and performance elements. Based on the system model......This research centres on assembly systems designed for utilizing product modularization. Altogether, the task for companies has become an issue of managing the overall trade-off between the external market’s desire for variety and the internal efficiency and effectiveness. Product modularization...... is often claimed to be the answer to this trade-off in the extant literature. The overall research purpose has been to investigate the phenomena of product modularization as an apparently both powerful and com-plex means. The focal research objective is to obtain an improved insight and understanding...

  6. Facilitating problem based learning in an online biology laboratory course

    Science.gov (United States)

    Wesolowski, Meredith C.

    Online instruction offers many benefits to underserved populations in higher education, particularly increased access. However, incorporation of preferred pedagogical methods, particularly those involving student collaboration, can be more difficult to facilitate in online courses due to geographic separation. In the area of laboratory science education, there is a strong argument for use of constructivist, collaborative pedagogy to promote many facets of student learning. This EPP describes the process used to develop two problem based learning (PBL) laboratory activities based on recommendations found in the literature, their incorporation into an online biology laboratory science course (BIO101) and their impact on student achievement and critical thinking skills. Data analysis revealed a high level of achievement within the study semester. In addition, use of synchronous group discussions as part of the PBL framework resulted in a broad range of discussions reflective of successful problem solving interactions described in the literature. Together, these suggest a observed benefit from incorporation of PBL in this online course. In addition, specific areas for modification were identified as potential future improvements.

  7. Targeted editing of goat genome with modular-assembly zinc finger nucleases based on activity prediction by computational molecular modeling.

    Science.gov (United States)

    Xiong, Kai; Li, Shanshan; Zhang, Hongxiao; Cui, Ye; Yu, Debing; Li, Yan; Sun, Wenxing; Fu, Yingying; Teng, Yun; Liu, Zhi; Zhou, Xiaolong; Xiao, Peng; Li, Juan; Liu, Honglin; Chen, Jie

    2013-07-01

    Zinc finger nuclease (ZFN) technology can mediate targeted genome modification to produce transgenic animals in a high-efficient and biological-safe way. Modular assembly is a rapid, convenient and open-source method for the synthesis of ZFNs. However, this biotechnology is hampered by multistep construction, low-efficiency editing and off-target cleavage. Here we synthesized and tested six pairs of three- or four-finger ZFNs to target one site in goat beta-lactoglobulin (BLG, a dominant allergen in goat milk) gene. Homology modeling was applied to build the structure model of ZFNs to predict their editing activities targeting at goat BLG gene. Goat fibroblast cells were transfected with plasmids that encoded ZFN pairs, and genomic DNA was isolated 72 h later for genome editing efficiency assay. The results of editing efficiency assay demonstrated that ZFNs with optimal interaction modes can edit goat BLG gene more efficiently, whereas ZFNs with unexpected interaction modes showed lower activities in editing BLG gene. We concluded that modular-assembly ZFNs can provide a rapid, public-available, and easy-to-practice platform for transgenic animal research and molecular modeling would help as a useful tool for ZFNs activity prediction.

  8. Modularity in New Market Formation

    DEFF Research Database (Denmark)

    Sanchez, Ron; Hang, Chang Chieh

    2017-01-01

    the formation of an industrial base of assemblers and component suppliers, assisting new firms in building customer relationships, enabling more geographically diffused economic development within countries, and facilitating development of export markets. We also suggest directions for further research......In this paper we appraise the ways in which use of closed-system proprietary product architectures versus open-system modular product architectures is likely to influence the dynamics and trajectory of new product market formation. We compare the evolutions of new markets in China for gas...... as the basis for new kinds of products may result in very different patterns and speeds of new market formation. We then suggest some key implications of the different dynamics of market formation associated with open-system modular architectures for both the competence-based strategic management (CBSM...

  9. Modularity in Sensory Auditory Memory

    OpenAIRE

    Clement, Sylvain; Moroni, Christine; Samson, Séverine

    2004-01-01

    The goal of this paper was to review various experimental and neuropsychological studies that support the modular conception of auditory sensory memory or auditory short-term memory. Based on initial findings demonstrating that verbal sensory memory system can be dissociated from a general auditory memory store at the functional and anatomical levels. we reported a series of studies that provided evidence in favor of multiple auditory sensory stores specialized in retaining eit...

  10. Procedimento para seleção de interfaces para produtos modulares baseado no ciclo de projeto de produtos Procedure for interface selection for modular products based on the product design cycle

    Directory of Open Access Journals (Sweden)

    Régis Kovacs Scalice

    2012-12-01

    Full Text Available Este artigo aborda a definição de alternativas de interfaces durante desenvolvimento de produtos modulares. Entende-se por interfaces a fronteira entre os módulos que compõem o produto, bem como as interações existentes entre o meio-ambiente em que o produto está inserido e com seus possíveis usuários. Para realizar o projeto de interfaces é proposto um procedimento que auxilia na concepção de alternativas e em sua priorização, de forma a facilitar a tomada de decisão por parte da equipe de projeto. O procedimento proposto foi validado por sua aplicação no desenvolvimento de produtos modulares para o cultivo e beneficiamento de mexilhões em Santa Catarina. Os resultados obtidos demonstram o potencial da ferramenta.This paper deals with the definition of interface alternatives during the development of modular products. Interfaces could be seen as the boundary between modules, as well the existing interactions with the surrounding environment and possible users. In order to carry out interface design, a procedure to aid in the conception of interface alternatives and their ranking is proposed, assisting the design team on decision-making. The procedure proposed was validated during the design of modular products for mussel farming and processing in the State of Santa Catarina. The results achieved show the potential of this design tool.

  11. Modular version of SIMCON, FPGA based, DSP integrated, LLRF control system for TESLA FEL part II: measurement of SIMCON 3.0 DSP daughterboard

    Science.gov (United States)

    Giergusiewicz, Wojciech; Koprek, Waldemar; Jalmuzna, Wojciech; Pozniak, Krzysztof T.; Romaniuk, Ryszard S.

    2006-02-01

    The paper describes design, construction and initial measurements of an eight channel electronic LLRF device predicted for building of the control system for the W-FEL accelerator at DESY (Hamburg). The device, referred in the paper to as the SIMCON 3.0 (from the SC cavity simulator and controller) consists of a 16 layer, VME size, PCB, a large FPGA chip (VirtexII-4000 by Xilinx), eight fast ADCs and four DACs (by Analog Devices). To our knowledge, the proposed device is the first of this kind for the accelerator technology in which there was achieved (the FPGA based) DSP latency below 200 ns. With the optimized data transmission system, the overall LLRF system latency can be as low as 500 ns. The SIMCON 3.0 sub-system was applied for initial tests with the ACCl module of the VUV FEL accelerator (eight channels) and with the CHECHIA test stand (single channel), both at the DESY. The promising results with the SIMCON 3.0. encouraged us to enter the design of SIMCON 3.1. possessing 10 measurement and control channels and some additional features to be reported in the next technical note. SIMCON 3.0. is a modular solution, while SIMCON 3.1. will be an integrated board of the all-in-one type. Two design approaches - modular and all-in-one - after branching off in this version of the Simcon, will be continued.

  12. An electronic laboratory notebook based on the World Wide Web

    Energy Technology Data Exchange (ETDEWEB)

    Marstaller, J.E.; Zorn, M.D.

    1995-10-01

    The LBNL/UCSF Resource for Molecular Cytogenetics has been created to facilitate the application of molecular cytogenetics in clinical and biological studies. One of the primary tasks is the selection of probes optimized for use in fluorescence in situ hybridization (FISH). Our group provides data management support for all the activities in the Resource. In this paper we describe an electronic laboratory notebook based on the World Wide Web. The data are located in a central database. The user interface consists of a set of HTML forms that handle data input and retrieval from a database from two locations several miles apart. A WWW client allows users to formulate retrieval and edit operations that are sent to the database. Results are filtered through Perl scripts which generate HTML documents with Hypertext links that are sent back to the client. Besides tracking laboratory information through the various stages in the biology laboratory, the system also feeds into a public web server that makes the data available to the community.

  13. Simulation-based medical education in clinical skills laboratory.

    Science.gov (United States)

    Akaike, Masashi; Fukutomi, Miki; Nagamune, Masami; Fujimoto, Akiko; Tsuji, Akiko; Ishida, Kazuko; Iwata, Takashi

    2012-01-01

    Clinical skills laboratories have been established in medical institutions as facilities for simulation-based medical education (SBME). SBME is believed to be superior to the traditional style of medical education from the viewpoint of the active and adult learning theories. SBME can provide a learning cycle of debriefing and feedback for learners as well as evaluation of procedures and competency. SBME offers both learners and patients a safe environment for practice and error. In a full-environment simulation, learners can obtain not only technical skills but also non-technical skills, such as leadership, team work, communication, situation awareness, decision-making, and awareness of personal limitations. SBME is also effective for integration of clinical medicine and basic medicine. In addition, technology-enhanced simulation training is associated with beneficial effects for outcomes of knowledge, skills, behaviors, and patient-related outcomes. To perform SBME, effectively, not only simulators including high-fidelity mannequin-type simulators or virtual-reality simulators but also full-time faculties and instructors as professionals of SBME are essential in a clinical skills laboratory for SBME. Clinical skills laboratory is expected to become an integrated medical education center to achieve continuing professional development, integrated learning of basic and clinical medicine, and citizens' participation and cooperation in medical education.

  14. Automatic Modeling and Simulation of Modular Robots

    Science.gov (United States)

    Jiang, C.; Wei, H.; Zhang, Y.

    2018-03-01

    The ability of reconfiguration makes modular robots have the ability of adaptable, low-cost, self-healing and fault-tolerant. It can also be applied to a variety of mission situations. In this manuscript, a robot platform which relied on the module library was designed, based on the screw theory and module theory. Then, the configuration design method of the modular robot was proposed. And the different configurations of modular robot system have been built, including industrial mechanical arms, the mobile platform, six-legged robot and 3D exoskeleton manipulator. Finally, the simulation and verification of one system among them have been made, using the analyses of screw kinematics and polynomial planning. The results of experiments demonstrate the feasibility and superiority of this modular system.

  15. Low Cost ZigBee Protocol Based Laboratory Platforms

    Directory of Open Access Journals (Sweden)

    Alvaro Romero-Acero

    2013-11-01

    Full Text Available This paper presents a low cost wireless communication platform, based on the ZigBee protocol. It is designed with the purpose to strengthen the use of information technology in the classroom. Guides laboratory practices are focused on developing undergraduate engineering students to the area of telecommunications. The platform structure is composed of: Labs custom designed, web tools embedded wireless communication system for data acquisition in real time, and the Human Machine Interface (HMI, which records analog data and digital. 

  16. Duality ensures modular covariance

    International Nuclear Information System (INIS)

    Li Miao; Yu Ming

    1989-11-01

    We show that the modular transformations for one point functions on the torus, S(n), satisfy the polynomial equations derived by Moore and Seiberg, provided the duality property of the model is ensured. The formula for S(n) is derived by us previously and should be valid for any conformal field theory. As a consequence, the full consistency conditions for modular invariance at higher genus are completely guaranteed by duality of the theory on the sphere. (orig.)

  17. Genome modularity and synthetic biology: Engineering systems.

    Science.gov (United States)

    Mol, Milsee; Kabra, Ritika; Singh, Shailza

    2018-01-01

    Whole genome sequencing projects running in various laboratories around the world has generated immense data. A systematic phylogenetic analysis of this data shows that genome complexity goes on decreasing as it evolves, due to its modular nature. This modularity can be harnessed to minimize the genome further to reduce it with the bare minimum essential genes. A reduced modular genome, can fuel progress in the area of synthetic biology by providing a ready to use plug and play chassis. Advances in gene editing technology such as the use of tailor made synthetic transcription factors will further enhance the availability of synthetic devices to be applied in the fields of environment, agriculture and health. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Modular Stellarator Fusion Reactor concept

    International Nuclear Information System (INIS)

    Miller, R.L.; Krakowski, R.A.

    1981-08-01

    A preliminary conceptual study is made of the Modular Stellarator Reactor (MSR). A steady-state ignited, DT-fueled, magnetic fusion reactor is proposed for use as a central electric-power station. The MSR concept combines the physics of the classic stellarator confinement topology with an innovative, modular-coil design. Parametric tradeoff calculations are described, leading to the selection of an interim design point for a 4-GWt plant based on Alcator transport scaling and an average beta value of 0.04 in an l = 2 system with a plasma aspect ratio of 11. The physics basis of the design point is described together with supporting magnetics, coil-force, and stress computations. The approach and results presented herein will be modified in the course of ongoing work to form a firmer basis for a detailed conceptual design of the MSR

  19. Service Modularity and Architecture

    DEFF Research Database (Denmark)

    Brax, Saara A.; Bask, Anu; Hsuan, Juliana

    2017-01-01

    Purpose: Services are highly important in a world economy which has increasingly become service driven. There is a growing need to better understand the possibilities for, and requirements of, designing modular service architectures. The purpose of this paper is to elaborate on the roots of the e......Purpose: Services are highly important in a world economy which has increasingly become service driven. There is a growing need to better understand the possibilities for, and requirements of, designing modular service architectures. The purpose of this paper is to elaborate on the roots...... of the emerging research stream on service modularity, provide a concise overview of existing work on the subject, and outline an agenda for future research on service modularity and architecture. The articles in the special issue offer four diverse sets of research on service modularity and architecture. Design....../methodology/approach: The paper is built on a literature review mapping the current body of literature on the topic and developing future research directions in service modularity and architecture. Findings: The growing focus on services has triggered needs to investigate the suitability and implementation of physical...

  20. Habidite: viviendas modulares industrializadas

    Directory of Open Access Journals (Sweden)

    Gómez Jáuregui, V.

    2009-03-01

    Full Text Available This paper is an introduction to one of the most relevant constructive systems of the last years: The integral industrialized construction. This method, based on three-dimensional modules, produces buildings made mainly from spatial cells of big dimensions; these three-dimensional modules are fabricated entirely in factory and, once they are finished, they are carried out to the site, where they are assembled in an easy manner. Even though it’s not a totally new system (in fact, the precedents will also be mentioned in this essay, Habidite is very confident in backing this tendency and doing its part in order to obtain modular reinforced concrete buildings of extraordinary quality, with domotic implements totally integrated in the dwellings and a high degree of sustainability, eco-technology and energetic efficiency. Many advantages are exposed and explained, dealing with the optimization of the productive processes in construction by means of the most advanced technologies.En este artículo se realiza una breve introducción a uno de los sistemas constructivos que más auge está teniendo en los últimos años: la edificación industrializada integral. Realizado a base de módulos tridimensionales, es éste un método de construcción en el cual los edificios se conforman básicamente por medio de células espaciales de grandes dimensiones; estos módulos tridimensionales se elaboran íntegramente en fábrica y, una vez están totalmente terminados, se transportan a obra, donde son montados de forma sencilla y rápida. Aunque no es un sistema totalmente novedoso (de hecho sus antecedentes también serán tratados brevemente en este texto, Habidite apuesta fuertemente por esta tendencia y aporta su grano de arena para conseguir edificios modulares de hormigón armado de extraordinaria calidad, con implementos domóticos totalmente integrados en la vivienda y un alto grado de sostenibilidad, eco-tecnología y eficiencia energética. Se abordan

  1. A Laboratory-Based System for Managing and Distributing Publically Funded Geochemical Data in a Collaborative Environment

    Science.gov (United States)

    McInnes, B.; Brown, A.; Liffers, M.

    2015-12-01

    Publically funded laboratories have a responsibility to generate, archive and disseminate analytical data to the research community. Laboratory managers know however, that a long tail of analytical effort never escapes researchers' thumb drives once they leave the lab. This work reports on a research data management project (Digital Mineralogy Library) where integrated hardware and software systems automatically archive and deliver analytical data and metadata to institutional and community data portals. The scientific objective of the DML project was to quantify the modal abundance of heavy minerals extracted from key lithological units in Western Australia. The selected analytical platform was a TESCAN Integrated Mineral Analyser (TIMA) that uses EDS-based mineral classification software to image and quantify mineral abundance and grain size at micron scale resolution. The analytical workflow used a bespoke laboratory information management system (LIMS) to orchestrate: (1) the preparation of grain mounts with embedded QR codes that serve as enduring links between physical samples and analytical data, (2) the assignment of an International Geo Sample Number (IGSN) and Digital Object Identifier (DOI) to each grain mount via the System for Earth Sample Registry (SESAR), (3) the assignment of a DOI to instrument metadata via Research Data Australia, (4) the delivery of TIMA analytical outputs, including spatially registered mineralogy images and mineral abundance data, to an institutionally-based data management server, and (5) the downstream delivery of a final data product via a Google Maps interface such as the AuScope Discovery Portal. The modular design of the system permits the networking of multiple instruments within a single site or multiple collaborating research institutions. Although sharing analytical data does provide new opportunities for the geochemistry community, the creation of an open data network requires: (1) adopting open data reporting

  2. Computationally efficient and flexible modular modelling approach for river and urban drainage systems based on surrogate conceptual models

    Science.gov (United States)

    Wolfs, Vincent; Willems, Patrick

    2015-04-01

    Water managers rely increasingly on mathematical simulation models that represent individual parts of the water system, such as the river, sewer system or waste water treatment plant. The current evolution towards integral water management requires the integration of these distinct components, leading to an increased model scale and scope. Besides this growing model complexity, certain applications gained interest and importance, such as uncertainty and sensitivity analyses, auto-calibration of models and real time control. All these applications share the need for models with a very limited calculation time, either for performing a large number of simulations, or a long term simulation followed by a statistical post-processing of the results. The use of the commonly applied detailed models that solve (part of) the de Saint-Venant equations is infeasible for these applications or such integrated modelling due to several reasons, of which a too long simulation time and the inability to couple submodels made in different software environments are the main ones. Instead, practitioners must use simplified models for these purposes. These models are characterized by empirical relationships and sacrifice model detail and accuracy for increased computational efficiency. The presented research discusses the development of a flexible integral modelling platform that complies with the following three key requirements: (1) Include a modelling approach for water quantity predictions for rivers, floodplains, sewer systems and rainfall runoff routing that require a minimal calculation time; (2) A fast and semi-automatic model configuration, thereby making maximum use of data of existing detailed models and measurements; (3) Have a calculation scheme based on open source code to allow for future extensions or the coupling with other models. First, a novel and flexible modular modelling approach based on the storage cell concept was developed. This approach divides each

  3. Metallic Modular Taper Junctions in Total Hip Arthroplasty

    Directory of Open Access Journals (Sweden)

    Timothy McTighe

    2015-08-01

    Full Text Available The emergence of modularity in total hip arthroplasty (THA in the 1980s and 1990s was based on the fact that the benefit of these design features outweighed the risk. The use of metallic modular junctions presents a unique set of advantages and problems for use in THA. The advantages include improvement in fit and fill of the implant to bone, restoration of joint mechanics, reduced complications in revision surgery and reduction of costly inventory. However, the risks or concerns are a little harder to identify and deal with. Certainly corrosion, and fatigue failure are the two most prevalent concerns but now the specifics of fretting wear and corrosive wear increasing particulate debris and the potential biological response is having an impact on the design and potential longevity of the reconstructed hip. Material and designs are facing a shorter life expectancy than what was previously thought, mostly due to an increasing level of physical activity by the patient. Because there are no accurate laboratory test whereby the service life and performance of these implants can be predicted, early controlled clinical evaluations are necessary. Early publication of testing and clinical impressions should be encouraged in an attempt to reduce exposure to potential at risk patients, implants and material. The reduction and possible elimination of risks will require a balancing of all the variables requiring a multidisciplinary endeavor. This paper is designed to review the risk factors, and benefits of modular junctions in total hip arthroplasty (THA. Also some basic engineering principals that can reduce risk factors and improve functionality of modular junctions.

  4. Organization of a radioisotope based molecular biology laboratory

    International Nuclear Information System (INIS)

    2006-12-01

    Polymerase chain reaction (PCR) has revolutionized the application of molecular techniques to medicine. Together with other molecular biology techniques it is being increasingly applied to human health for identifying prognostic markers and drug resistant profiles, developing diagnostic tests and genotyping systems and for treatment follow-up of certain diseases in developed countries. Developing Member States have expressed their need to also benefit from the dissemination of molecular advances. The use of radioisotopes, as a step in the detection process or for increased sensitivity and specificity is well established, making it ideally suitable for technology transfer. Many molecular based projects using isotopes for detecting and studying micro organisms, hereditary and neoplastic diseases are received for approval every year. In keeping with the IAEA's programme, several training activities and seminars have been organized to enhance the capabilities of developing Member States to employ in vitro nuclear medicine technologies for managing their important health problems and for undertaking related basic and clinical research. The background material for this publication was collected at training activities and from feedback received from participants at research and coordination meetings. In addition, a consultants' meeting was held in June 2004 to compile the first draft of this report. Previous IAEA TECDOCS, namely IAEA-TECDOC-748 and IAEA-TECDOC-1001, focused on molecular techniques and their application to medicine while the present publication provides information on organization of the laboratory, quality assurance and radio-safety. The technology has specific requirements of the way the laboratory is organized (e.g. for avoiding contamination and false positives in PCR) and of quality assurance in order to provide accurate information to decision makers. In addition while users of the technology accept the scientific rationale of using radio

  5. On sub-modularization and morphological heterogeneity in modular robotics

    DEFF Research Database (Denmark)

    Lyder, A. H.; Stoy, K.; Garciá, R. F. M.

    2012-01-01

    Modular robots are a kind of robots built from mechatronic modules, which can be assembled in many different ways allowing the modular robot to assume a wide range of morphologies and functions. An important question in modular robotics is to which degree modules should be heterogeneous. In this ......Modular robots are a kind of robots built from mechatronic modules, which can be assembled in many different ways allowing the modular robot to assume a wide range of morphologies and functions. An important question in modular robotics is to which degree modules should be heterogeneous...

  6. Modularity in New Market Formation

    DEFF Research Database (Denmark)

    Sanchez, Ron; Hang, Chang Chieh

    2017-01-01

    -powered two-wheeled vehicles (G2WVs) based (initially) on closed-system proprietary architectures and for electric-powered two-wheeled vehicles (E2WVs) based on open-system modular architectures. We draw on this comparison to suggest ways in which the use of the two different kinds of architectures...... the formation of an industrial base of assemblers and component suppliers, assisting new firms in building customer relationships, enabling more geographically diffused economic development within countries, and facilitating development of export markets. We also suggest directions for further research...

  7. Modular Lego-Electronics

    KAUST Repository

    Shaikh, Sohail F.

    2017-10-24

    Electronic system components have thousands of individual field effect transistors (FETs) interconnected executing dedicated functions. Assembly yield of >80% will guarantee system failure since a single interconnect failure will result in undesired performance. Hence, a paradigm shift is needed in the self-assembly or integration of state-of-the-art integrated circuits (ICs) for a physically compliant system. Traditionally, most ICs share same geometry with only variations in dimensions and packaging. Here, a generic manufacturable method of converting state-of-the-art complementary metal oxide semiconductor-based ICs into modular Lego-electronics is shown with unique geometry that is physically identifiable to ease manufacturing and enhance throughput. Various geometries at the backside of the silicon die and on the destination site having the same geometry with relaxed dimension (up to 50 µm extra) allow targeted site binding like DNA assembly. Different geometries, angles, and heights for different modules provide a unique identity to each of the ICs. A two-level geometric combination presented here helps in maintaining the uniqueness of individual module to assemble at exact matching site like a perfect lock-and-key model. The assembled ICs offer uncompromised electrical performance, higher yield, and fabrication ease. In future, this method can further be expanded for fluidic assisted self-assembly.

  8. A New Modular Multilevel Converter with Integrated Energy Storage

    DEFF Research Database (Denmark)

    Trintis, Ionut; Munk-Nielsen, Stig; Teodorescu, Remus

    2011-01-01

    This paper introduces a new modular converter with integrated energy storage based on the cascaded half-bridge modular multilevel converter with common DC bus. It represents a complete modular solution with power electronics and energy storage building blocks, for medium and high voltage...... in the future HVDC meshed grids. Its functionality and flexibility makes the converter independent on the energy storage unit characteristic. The converter concept with its basic functions and control schemes are described and evaluated in this paper....

  9. A Modular Cascaded Multilevel Inverter Based Shunt Hybrid Active Power Filter for Selective Harmonic and Reactive Power Compensation Under Distorted/Unbalanced Grid Voltage Conditions

    Directory of Open Access Journals (Sweden)

    T. Demirdelen

    2016-10-01

    Full Text Available In recent years, shunt hybrid active power filters are being increasingly considered as a viable alternative to both passive filters and active power filters for compensating harmonics. In literature, their applications are restricted to balanced systems and low voltage applications and therefore not for industrial applications. This paper investigates the performance of a modular cascaded multilevel inverter based Shunt Hybrid Active Power Filter (SHAPF for reactive power compensation and selective harmonics elimination under distorted/unbalanced grid voltage conditions in medium voltage levels. In the proposed control method, reactive power compensation is achieved successfully with a perceptible amount and the performance results of harmonic compensation are satisfactory. Theoretical analysis and simulation results are obtained from an actual industrial network model in PSCAD. The simulation results are presented for a proposed system in order to demonstrate that the harmonic compensation performance meets the IEEE-519 standard.

  10. Battery Management System—Balancing Modularization Based on a Single Switched Capacitor and Bi-Directional DC/DC Converter with the Auxiliary Battery

    Directory of Open Access Journals (Sweden)

    Mohamed Daowd

    2014-04-01

    Full Text Available Lithium-based batteries are considered as the most advanced batteries technology, which can be designed for high energy or high power storage systems. However, the battery cells are never fully identical due to the fabrication process, surrounding environment factors and differences between the cells tend to grow if no measures are taken. In order to have a high performance battery system, the battery cells should be continuously balanced for maintain the variation between the cells as small as possible. Without an appropriate balancing system, the individual cell voltages will differ over time and battery system capacity will decrease quickly. These issues will limit the electric range of the electric vehicle (EV and some cells will undergo higher stress, whereby the cycle life of these cells will be shorter. Quite a lot of cell balancing/equalization topologies have been previously proposed. These balancing topologies can be categorized into passive and active balancing. Active topologies are categorized according to the active element used for storing the energy such as capacitor and/or inductive component as well as controlling switches or converters. This paper proposes an intelligent battery management system (BMS including a battery pack charging and discharging control with a battery pack thermal management system. The BMS user input/output interfacing. The battery balancing system is based on battery pack modularization architecture. The proposed modularized balancing system has different equalization systems that operate inside and outside the modules. Innovative single switched capacitor (SSC control strategy is proposed to balance between the battery cells in the module (inside module balancing, IMB. Novel utilization of isolated bidirectional DC/DC converter (IBC is proposed to balance between the modules with the aid of the EV auxiliary battery (AB. Finally an experimental step-up has been implemented for the validation of the

  11. Online Fault Identification Based on an Adaptive Observer for Modular Multilevel Converters Applied to Wind Power Generation Systems

    Directory of Open Access Journals (Sweden)

    Hui Liu

    2015-07-01

    Full Text Available Due to the possibility of putting a large number of modules consisting of switches and capacitors connected in series, the modular multilevel converter (MMC can easily be scaled to high power and high voltage power conversion, which is an attractive feature for filter-less and transformer-less design and helpful to achieve high efficiency. However, a significantly increased amount of sub-modules in a MMC may increase the requirements for sensors and also increase the risk of failures. As a result, fault detection and diagnosis of MMC sub-modules are of great importance for continuous operation and post-fault maintenance. Therefore, in this paper, an effective fault diagnosis technique for real-time diagnosis of the switching device faults covering both the open-circuit faults and the short-circuit faults in MMC sub-modules is proposed, in which the faulty phase and the fault type is detected by analyzing the difference among the three output load currents, while the localization of the faulty switches is achieved by comparing the estimation results by the adaptive observer. In contrast to other methods that use additional sensors or devices, the presented technique uses the measured phase currents only, which are already available for MMC control. In additional, its operation, effectiveness and robustness are confirmed by simulation results under different operating conditions and load conditions.

  12. Plant systems/components modularization study. Final report. [PWR

    Energy Technology Data Exchange (ETDEWEB)

    1977-07-01

    The final results are summarized of a Plant Systems/Components Modularization Study based on Stone and Webster's Pressurized Water Reactor Reference Design. The program has been modified to include evaluation of the most promising areas for modular consideration based on the level of the Sundesert Project engineering design completion and the feasibility of their incorporation into the plant construction effort.

  13. Modular reconfigurable machines incorporating modular open architecture control

    CSIR Research Space (South Africa)

    Padayachee, J

    2008-01-01

    Full Text Available is presented. By virtue of their fully modular nature these machines are able to display a variability of machining functions and cutting degrees of freedom on a single platform. A corresponding modular Open Architecture Control (OAC) system is presented..., Modular Reconfigurable Machines, Open Architecture Control, Modular Machine Control I. INTRODUCTION Reconfigurable Manufacturing Systems (RMS) is a new class of manufacturing systems, having been created to overcome the inadequacies of previous...

  14. Modular Robotic Wearable

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop; Pagliarini, Luigi

    2009-01-01

    In this concept paper we trace the contours and define a new approach to robotic systems, composed of interactive robotic modules which are somehow worn on the body. We label such a field as Modular Robotic Wearable (MRW). We describe how, by using modular robotics for creating wearable......, it is possible to obtain a flexible wearable processing system, where freely inter-changeable input/output modules can be positioned on the body suit in accordance with the task at hand. We describe the first rough prototypes and show an artistic application, as well as some drawing of future works and projects....... Finally, by focusing on the intersection of the combination modular robotic systems, wearability, and bodymind we attempt to explore the theoretical characteristics of such approach and exploit the possible playware application fields....

  15. Modular playware as a playful diagnosis tool for autistic children

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop

    2009-01-01

    Based upon user-configurable modular robotics and design principles for modular playware, we developed modular robotic tiles to be used as playful, interactive tools for children with autism. The modular playware can make automatic documentation of the construction play activities by the autistic...... robotic tiles. Preliminary experiments with 7 autistic children show that the automatic neural network classification with post-processing can be done with a 100% accuracy for this small sample set, and thereby give some preliminary indications of the potential of the approach....

  16. [The modular strategy for the informational support of medical activities based at the spa and health resort facilities under conditions of infrastructure deficit].

    Science.gov (United States)

    Yezhov, V V; Goldberg, D L; Grigorev, P E; Mizin, V I; Olenchuk, A V; Vasilieva, I V

    2017-12-05

    The Crimean peninsula, by virtue of its unique geographical conditions, has a variety of natural resources providing a basis for the maintenance of the health resort activities in the region. However, most local health centers suffer from the chronic and difficultly avoidable in the short term problems with logistical support, including the shortage of computers and the lack of modern network infrastructure. This circumstance limits the deployment capabilities of high-grade medical information systems for the automation of all components of the activity of health resorts and the significant improvement of the performance of other aspects of their work, such as efficient patient routing, workflow optimization, limiting the opportunities for the realization of certain corruption schemes by the staff. We have studied the routing of patients and the associated document flow in a number of Crimean spa and health resort facilities (sanatoriums). As a result, the basic work places at which information contained in the documents is undergoing changes were identified. Based on these data, the basic (modular) concept of the development of medical information system was formulated. According to the principle of modularity, the structure of the information system has been modified and optimized. The stages of implementation of this approach at various levels of logistic facilities were described, defined and justified. The key feature of the proposed system consists in that even the minimal equipment of computing infrastructure units (starting from a single workplace, such as a «medical receptionist») may be sufficient to achieve the significant degree of automation in the workflow, provide monitoring and analysis of the medical records of the spa and health resort facilities. By gradually increasing the number of related automated workplaces and modules, it is possible to expand the capabilities of the system up to the full automation of a given health resort facility.

  17. Collaborative Modular Pumped Hydro Energy Storage Design Study

    Energy Technology Data Exchange (ETDEWEB)

    Bibeault, Mark Leonide [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Roybal, Adam [Jemez Mountain Electric Cooperative, Inc., Hernandez, NM (United States); Bailey, Jr., Richard J. [Northern New Mexico College, Espanola, NM (United States)

    2017-09-29

    In May of 2017, Los Alamos National Laboratory (LANL) through the Applied Engineering Technology Division, Jemez Mountain Electric Cooperative Inc. (JMEC), and Northern New Mexico College (NNMC) agreed to enter into a small, joint, non-binding Modular Pumped Hydro (MPH) design study related to grid level energy storage to begin a process of collaboration. Los Alamos National Laboratory's mission is to solve national security challenges through scientific excellence. The mission of Northern New Mexico College is to ensure student success by providing access to affordable, community-based learning opportunities that meet the educational, cultural, and economic needs of the region. Jemez Mountain Electric Cooperative Inc. is the largest electric co-op in the State of New Mexico providing affordable and reliable electricity to customers in the five counties of Rio Arriba, Santa Fe, San Juan, McKinley and Sandoval.

  18. Modular High Voltage Power Supply

    Energy Technology Data Exchange (ETDEWEB)

    Newell, Matthew R. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-05-18

    The goal of this project is to develop a modular high voltage power supply that will meet the needs of safeguards applications and provide a modular plug and play supply for use with standard electronic racks.

  19. An open microcomputer-based laboratory system for perceptional experimentality

    Science.gov (United States)

    Hamalainen, Ari

    A computer, equipped with hardware for acquiring data about the properties of a physical system and programs for processing that data, is a powerful tool for physics research and instruction. There is strong evidence that utilizing microcomputer-based laboratories (MBLs) in instruction can lead to significantly improved learning. The perceptional approach is a method for physics instruction, developed at the Department of Physics, University of Helsinki. Its main arguments are that the meanings of the concepts must be learnt before their formal definitions and adoption, and that learning and research are fundamentally similar concept formation processes. Applying the perceptional approach requires the ability to perform quantitative experiments, either as students' laboratory exercises or as lecture demonstrations, and to process their results. MBL tools are essential for this. In student's laboratory exercises, they reduce the routine work and leave more time for the actual learning. In lecture demonstrations, they make it possible to perform the experiments in the tight time limits. At a previous stage of the research, a set of requirements was found that the perceptional approach places on MBL systems. The primary goal of this thesis is to build a prototype of a MBL system that would fulfil these requirements. A secondary goal is to describe technical aspects of a computerized measurement system from the standpoint of educational use. The prototype was built using mostly commercial sensors and data acquisition units. The software was written with a visual programming language, designed for instrumentation applications. The prototype system was developed and tested with a set of demonstrations of various topics in the Finnish high school physics curriculum, which were implemented according to the perceptional approach. Limited usability tests were also performed. The prototype was improved, until it could perform the test demonstrations. It was found to meet the

  20. Fault Detection and Localization Method for Modular Multilevel Converters

    DEFF Research Database (Denmark)

    Deng, Fujin; Chen, Zhe; Khan, Mohammad Rezwan

    2015-01-01

    The modular multilevel converter (MMC) is attractive for medium- or high-power applications because of the advantages of its high modularity, availability, and high power quality. However, reliability is one of the most important issues for MMCs those are made of large number of power electronic...... prototype controlled by a real-time digital signal controller in the laboratory. The results confirm the effectiveness of the proposed method....

  1. Workflow and cost analysis on MODULAR ANALYTICS.

    Science.gov (United States)

    Stolz, Herbert; Dossler, Bettina; Keller, Franz; Steigerwald, Udo

    2003-01-01

    Four stand-alone analyzers in a centralized laboratory were replaced by two modular analytical systems processing 45 methods of the general chemistry and specific protein segment. This consolidation led to a reduction of the daily workflow and operational costs. The cost saving with 1.3 million reported results per year was 53,000 Euro, which can be assessed as an important contribution to cost reduction in the health care system.

  2. Modular Stirling Radioisotope Generator

    Science.gov (United States)

    Schmitz, Paul C.; Mason, Lee S.; Schifer, Nicholas A.

    2016-01-01

    High-efficiency radioisotope power generators will play an important role in future NASA space exploration missions. Stirling Radioisotope Generators (SRGs) have been identified as a candidate generator technology capable of providing mission designers with an efficient, high-specific-power electrical generator. SRGs high conversion efficiency has the potential to extend the limited Pu-238 supply when compared with current Radioisotope Thermoelectric Generators (RTGs). Due to budgetary constraints, the Advanced Stirling Radioisotope Generator (ASRG) was canceled in the fall of 2013. Over the past year a joint study by NASA and the Department of Energy (DOE) called the Nuclear Power Assessment Study (NPAS) recommended that Stirling technologies continue to be explored. During the mission studies of the NPAS, spare SRGs were sometimes required to meet mission power system reliability requirements. This led to an additional mass penalty and increased isotope consumption levied on certain SRG-based missions. In an attempt to remove the spare power system, a new generator architecture is considered, which could increase the reliability of a Stirling generator and provide a more fault-tolerant power system. This new generator called the Modular Stirling Radioisotope Generator (MSRG) employs multiple parallel Stirling convertor/controller strings, all of which share the heat from the General Purpose Heat Source (GPHS) modules. For this design, generators utilizing one to eight GPHS modules were analyzed, which provided about 50 to 450 W of direct current (DC) to the spacecraft, respectively. Four Stirling convertors are arranged around each GPHS module resulting in from 4 to 32 Stirling/controller strings. The convertors are balanced either individually or in pairs, and are radiatively coupled to the GPHS modules. Heat is rejected through the housing/radiator, which is similar in construction to the ASRG. Mass and power analysis for these systems indicate that specific

  3. Evolution of Modularity Literature

    DEFF Research Database (Denmark)

    Frandsen, Thomas

    2017-01-01

    Purpose The purpose of this paper is to review and analyze the modularity literature to identify the established and emerging perspectives. Design/methodology/approach A systematic literature search and review was conducted through the use of bibliometrics and network analysis. The analysis ident...

  4. MRV - Modular Robotic Vehicle

    Science.gov (United States)

    Ridley, Justin; Bluethmann, Bill

    2015-01-01

    The Modular Robotic Vehicle, or MRV, completed in 2013, was developed at the Johnson Space Center in order to advance technologies which have applications for future vehicles both in space and on Earth. With seating for two people, MRV is a fully electric vehicle modeled as a "city car", suited for busy urban environments.

  5. Modular invariant gaugino condensation

    Energy Technology Data Exchange (ETDEWEB)

    Gaillard, M.K.

    1991-05-09

    The construction of effective supergravity lagrangians for gaugino condensation is reviewed and recent results are presented that are consistent with modular invariance and yield a positive definite potential of the noscale type. Possible implications for phenomenology are briefly discussed. 29 refs.

  6. Modular co-ordination

    DEFF Research Database (Denmark)

    Blach, K.

    Notatet er på engelsk, idet det er lavet som et oplæg til den internationale standardiseringsorganisations (ISO) arbejde med målkoordinering i byggeriet. Materialet har også været forelagt ekspertgrupperne i CIB W24 og i International Modular Group. Det i notatet præsenterede materiale er blevet ...

  7. Large boiler modularization

    Energy Technology Data Exchange (ETDEWEB)

    MacKenzie, Malcolm [Babcock and Wilcox Canada Ltd (Canada)

    2011-07-01

    This paper presents the modularization strategy in boiler manufacture of Babcock and Wilcox Canada Ltd, designed specifically to provide steam capacities up to 1,000,000 lb/hr. Designed as a solution for the oil sands market, the boiler responds to the needs of steam assisted gravity drainage (SAGD) and other in situ processes. Manufacture of three modules: furnace, superheater, and saturated module, is detailed assembly phases are shown as well as the construction sequence. The boiler is bottom-supported and features a unique modularized design that maximizes shop assembly and provides certainty to delivery and overall project schedule. Moreover, it is adaptable for all liquid and gaseous fuel types, including natural gas, produced gas and emulsified liquid fuels. This highly modular solution makes it a comprehensive solution for projects where construction risks and costs would otherwise be prohibitive. Maximum modularization of the boiler and minimal site labour are key design features, ensuring compliance with the weight and dimensional constraints of Alberta's high load corridor.

  8. Dry Laboratories in Science Education : Computer-based Practical Work

    NARCIS (Netherlands)

    Kirschner, P.A.; Huisman, W.

    1998-01-01

    Practical (laboratory) work in science education has traditionally been used to allow students to rediscover already known concepts and ideas, to demonstrate concepts taught in the classroom or, in the case of inquirybased science curricula, to teach concepts. Often, these laboratory practicals do

  9. Laboratory diagnosis of toluene-based inhalants abuse.

    Science.gov (United States)

    Thiesen, Flavia Valladão; Noto, Ana Regina; Barros, Helena M T

    2007-01-01

    Toluene is the main substance contained in products used as inhalants. The frequent abuse of toluene-based inhalants requires the definition of a simple laboratory parameter that allows acute exposure assessment. This study aimed at defining urinary hippuric acid (UHA) levels related to intentional exposure to toluene, and to correlate them to blood toluene concentration (BT). BT and UHA levels were measured in 65 homeless adolescents of Porto Alegre, Brazil. Toluene was detected in 91.9% of the investigated population, who presented BT levels from 0.5 to 83.7 microg/mL. There was good correlation between UHA and BT concentrations (r = 0.78), and in homeless adolescents, UHA levels higher than 3.0 g/g creatinine indicate intentional exposure to toluene. The determination of UHA concentrations can be used as a screening method for the detection of intentional exposure to toluene, but its diagnosis must include BT toluene dosage, as well as circumstantial and clinical evidence.

  10. Modularization of Industrial Service Processes

    DEFF Research Database (Denmark)

    Frandsen, Thomas; Hsuan, Juliana

    In this paper we examine how complex service processes can be dealt with through the lenses of modularization strategies. Through an illustrative case study of a manufacturer of industrial equipment for process industries we propose the use of the service modularity function to conceptualize...... and assess the service modularity of service offerings. The measured degree of modularity would allow us to sharpen our understanding of modularity in the context of industrial services, such as the role of standardization and component reuse on architecture flexibility. It would also provide a foundation...

  11. DO TIE LABORATORY BASED ASSESSMENT METHODS REALLY PREDICT FIELD EFFECTS?

    Science.gov (United States)

    Sediment Toxicity Identification and Evaluation (TIE) methods have been developed for both porewaters and whole sediments. These relatively simple laboratory methods are designed to identify specific toxicants or classes of toxicants in sediments; however, the question of whethe...

  12. DO TIE LABORATORY BASED METHODS REALLY REFLECT FIELD CONDITIONS

    Science.gov (United States)

    Sediment Toxicity Identification and Evaluation (TIE) methods have been developed for both interstitial waters and whole sediments. These relatively simple laboratory methods are designed to identify specific toxicants or classes of toxicants in sediments; however, the question ...

  13. Enhancing laboratory activity with computer-based tutorials

    Directory of Open Access Journals (Sweden)

    Gordon Ritchie

    1995-12-01

    Full Text Available In a degree course in electronic engineering, great importance is attached to laboratory work, in which students have the opportunity to develop their creative skills in a practical environment. For example, in the first year of the course they are expected to design and test some basic circuits using data available on the characteristics of the semiconductor devices to be used. Many of the students cannot be prepared sufficiently for this activity by attendance at lectures, in which basic principles are expounded to large classes. Firstyear students have widely differing knowledge, experience and ability in circuit design. Therefore, without individual tuition many of them are insufficiently prepared for their laboratory work. Weaker students often neglect to study the laboratory documentation thoroughly in advance and they make poor progress in the laboratory.

  14. Laboratory-based surveillance in the molecular era: The typened model, a joint data-sharing platform for clinical and public health laboratories

    NARCIS (Netherlands)

    H.G.M. Niesters (Bert); J.W. Rossen (John); H.G.A.M. van der Avoort (Harrie); D. Baas; K. Benschop (Kimberley); E.C.J. Claas (Eric); A. Kroneman; N.M. van Maarseveen (Noortje); S.D. Pas (Suzan); W. van Pelt (Wilfred); J. Rahamat-Langendoen (Janette); R. Schuurman (Rob); H. Vennema (Harry); L. Verhoef; K.C. Wolthers (Katja); M.P.G. Koopmans D.V.M. (Marion)

    2013-01-01

    textabstractLaboratory-based surveillance, one of the pillars of monitoring infectious disease trends, relies on data produced in clinical and/or public health laboratories. Currently, diagnostic laboratories worldwide submit strains or samples to a relatively small number of reference laboratories

  15. Laboratory-based surveillance in the molecular era : the TYPENED model, a joint data-sharing platform for clinical and public health laboratories

    NARCIS (Netherlands)

    Niesters, H G; Rossen, J W; van der Avoort, H; Baas, D; Benschop, K; Claas, E C; Kroneman, A; van Maarseveen, N; Pas, S; van Pelt, W; Rahamat-Langendoen, J C; Schuurman, R; Vennema, H; Verhoef, L; Wolthers, K; Koopmans, Marion

    2013-01-01

    Laboratory-based surveillance, one of the pillars of monitoring infectious disease trends, relies on data produced in clinical and/or public health laboratories. Currently, diagnostic laboratories worldwide submit strains or samples to a relatively small number of reference laboratories for

  16. Laboratory-based surveillance in the molecular era: the TYPENED model, a joint data-sharing platform for clinical and public health laboratories

    NARCIS (Netherlands)

    Niesters, H. G.; Rossen, J. W.; van der Avoort, H.; Baas, D.; Benschop, K.; Claas, E. C.; Kroneman, A.; van Maarseveen, N.; Pas, S.; van Pelt, W.; Rahamat-Langendoen, J. C.; Schuurman, R.; Vennema, H.; Verhoef, L.; Wolthers, K.; Koopmans, M.

    2013-01-01

    Laboratory-based surveillance, one of the pillars of monitoring infectious disease trends, relies on data produced in clinical and/or public health laboratories. Currently, diagnostic laboratories worldwide submit strains or samples to a relatively small number of reference laboratories for

  17. Contrasting platform thinking and product modularization

    DEFF Research Database (Denmark)

    Boer, Henrike Engele Elisabeth; Persson, Magnus

    2015-01-01

    into an already existing product structure. Without using TRL classification and defined goals and gates, these firms can risk that immature technology is incorporated in their core platform and that their long-term platform-based plan for future product variants and successive generations is disrupted.......Product modularization and platform thinking are both practices that seek to alleviate the negative impact of product customization and variety on internal operations by relying on economies of substitution. Through the use of a standardized pool of components and interfaces, these practices aim...... to create a broad spectrum of product choices. At first sight, product modularization and platform thinking are very similar. The difference between these practices can, however, be found in the manner in which they employ standardization. Where product modularization focuses on creating standardized...

  18. An evaluation of the effects of a web-based modular teaching programme, housed within a virtual learning environment on orthodontic training for specialist registrars.

    Science.gov (United States)

    Mulgrew, Brian; Drage, Karen; Gardiner, Penny; Ireland, Tony; Sandy, Jonathan R

    2009-09-01

    A new modular teaching programme, housed within a virtual learning environment (VLE) was introduced in Bristol in 2004 to complement the academic training of orthodontic postgraduates. The aims of this study were to evaluate whether its introduction had reduced travel commitments for trainees, reduced demands on academic staff and whether it had any effect on teaching and learning. An investigative mixed methods study designed to collect and analyse verbal and written data. The South West Region of the UK. Semi-structured interviews and focus groups with nine trainees and 14 trainers were taped and transcribed. Written data were coded and analysed thematically. The qualitative data from interviews and focus groups were complemented with written data from trainee diaries and a limited amount of quantitative data collected from the VLE. Travel commitments for trainees have reduced as a result of introducing the web-based resource, but not as expected. Demands on academic staff have not reduced but have changed. The resource has had positive effects on postgraduate orthodontic teaching and learning. Important themes of interest emerging from the data are improvements in the flexibility and efficiency of learning and the value of the resource as a repository of information and in the organization of teaching and learning. Despite the popularity of this web based learning resource, trainees continue to value the opportunity to interact face to face with their teachers and peers and are prepared to travel for organized teaching sessions.

  19. Modular chemiresistive sensor

    Energy Technology Data Exchange (ETDEWEB)

    Alam, Maksudul M.; Sampathkumaran, Uma

    2018-02-20

    The present invention relates to a modular chemiresistive sensor. In particular, a modular chemiresistive sensor for hypergolic fuel and oxidizer leak detection, carbon dioxide monitoring and detection of disease biomarkers. The sensor preferably has two gold or platinum electrodes mounted on a silicon substrate where the electrodes are connected to a power source and are separated by a gap of 0.5 to 4.0 .mu.M. A polymer nanowire or carbon nanotube spans the gap between the electrodes and connects the electrodes electrically. The electrodes are further connected to a circuit board having a processor and data storage, where the processor can measure current and voltage values between the electrodes and compare the current and voltage values with current and voltage values stored in the data storage and assigned to particular concentrations of a pre-determined substance such as those listed above or a variety of other substances.

  20. Known Structure, Unknown Function: An Inquiry-Based Undergraduate Biochemistry Laboratory Course

    Science.gov (United States)

    Gray, Cynthia; Price, Carol W.; Lee, Christopher T.; Dewald, Alison H.; Cline, Matthew A.; McAnany, Charles E.; Columbus, Linda; Mura, Cameron

    2015-01-01

    Undergraduate biochemistry laboratory courses often do not provide students with an authentic research experience, particularly when the express purpose of the laboratory is purely instructional. However, an instructional laboratory course that is inquiry- and research-based could simultaneously impart scientific knowledge and foster a student's…

  1. Students' Perceptions of a Project-Based Organic Chemistry Laboratory Environment: A Phenomenographic Approach

    Science.gov (United States)

    Burrows, Nikita L.; Nowak, Montana K.; Mooring, Suazette R.

    2017-01-01

    Students can perceive the laboratory environment in a variety of ways that can affect what they take away from the laboratory course. This qualitative study characterizes undergraduate students' perspectives of a project-based Organic Chemistry laboratory using the theoretical framework of phenomenography. Eighteen participants were interviewed in…

  2. A LabVIEW based Remote DSP Laboratory

    Directory of Open Access Journals (Sweden)

    Athanasios Kalantzopoulos

    2008-07-01

    Full Text Available Remote laboratories provide the students with the capability to perform laboratory exercises exploiting the relevant equipment any time of the day without their physical presence. Furthermore, providing the ability to use a single workstation by more than one student, they contribute to the reduction of the laboratory cost. Turning to advantage the above and according to the needs of post graduate modules in the fields of DSP Systems Design and Signal Processing Systems with DSPs, we designed and developed a Remote DSP Laboratory. A student using a Web Browser has the ability via internet to turn to account the R-DSP Lab and perform experiments using DSPs (Digital Signal Processors. For now, there is the opportunity to carry out laboratory exercises such as FIR, IIR digital filters and FFT as well as run any executable file developed by the user. In any case the observation of the results is carried out through the use of specially designed Graphical User Interfaces (GUIs.

  3. Modular Regiospecific Synthesis of Nitrated Fatty Acids

    DEFF Research Database (Denmark)

    Hock, Katharina J.; Grimmer, Jennifer; Göbel, Dominik

    2016-01-01

    Endogenous nitrated fatty acids are an important class of signaling molecules. Herein a modular route for the efficient and regiospecific preparation of nitrooleic acids as well as various analogues is described. The approach is based on a simple set of alkyl halides as common building blocks...

  4. Modular Infrastructure for Rapid Flight Software Development

    Science.gov (United States)

    Pires, Craig

    2010-01-01

    This slide presentation reviews the use of modular infrastructure to assist in the development of flight software. A feature of this program is the use of model based approach for application unique software. A review of two programs that this approach was use on are: the development of software for Hover Test Vehicle (HTV), and Lunar Atmosphere and Dust Environment Experiment (LADEE).

  5. Modular interpreters with implicit context propagation

    NARCIS (Netherlands)

    P.A. Inostroza Valdera (Pablo); T. van der Storm (Tijs)

    2017-01-01

    textabstractModular interpreters are a crucial first step towards component-based language development: instead of writing language interpreters from scratch, they can be assembled from reusable, semantic building blocks. Unfortunately, traditional language interpreters can be hard to extend because

  6. Modular microfluidic system for biological sample preparation

    Science.gov (United States)

    Rose, Klint A.; Mariella, Jr., Raymond P.; Bailey, Christopher G.; Ness, Kevin Dean

    2015-09-29

    A reconfigurable modular microfluidic system for preparation of a biological sample including a series of reconfigurable modules for automated sample preparation adapted to selectively include a) a microfluidic acoustic focusing filter module, b) a dielectrophoresis bacteria filter module, c) a dielectrophoresis virus filter module, d) an isotachophoresis nucleic acid filter module, e) a lyses module, and f) an isotachophoresis-based nucleic acid filter.

  7. Modularity, Working Memory and Language Acquisition

    Science.gov (United States)

    Baddeley, Alan D.

    2017-01-01

    The concept of modularity is used to contrast the approach to working memory proposed by Truscott with the Baddeley and Hitch multicomponent model. This proposes four sub components comprising the "central executive," an executive control system of limited attentional capacity that utilises storage based on separate but interlinked…

  8. NMOS-Based Integrated Modular Bypass for Use in Solar Systems (NIMBUS: Intelligent Bypass for Reducing Partial Shading Power Loss in Solar Panel Applications

    Directory of Open Access Journals (Sweden)

    Pieter Bauwens

    2016-06-01

    Full Text Available NMOS-based Integrated Modular Bypass for Use in Solar systems (NIMBUS is designed as a replacement for the traditional bypass diode, used in common solar panels. Because of the series connection between the individual solar cells, the power output of a photovoltaic (PV panel will drop disproportionally under partial shading. Currently, this is solved by dividing the PV panel into substrings, each with a diode bypass placed in parallel. This allows an alternative current path. However, the diodes still have a significant voltage drop (about 350 mV, and due to the fairly large currents in a panel, the diodes are dissipating power that we would rather see at the output of the panel. The NIMBUS chip, being a low-voltage-drop switch, aims to replace these diodes and, thus, reduce that power loss. NIMBUS is a smart bypass: a completely stand-alone system that detects the failing of one or more cells and activates when necessary. It is designed for a 100-mV voltage drop under a 5-A load current. When two or more NIMBUS chips are placed in parallel, an internal synchronization circuit ensures proper operation to provide for larger load currents. This paper will elaborate on the operation, design and implementation of the NIMBUS chip, as well as on the first measurements.

  9. Representing and Reasoning with the Internet of Things: a Modular Rule-Based Model for Ensembles of Context-Aware Smart Things

    Directory of Open Access Journals (Sweden)

    S. W. Loke

    2016-03-01

    Full Text Available Context-aware smart things are capable of computational behaviour based on sensing the physical world, inferring context from the sensed data, and acting on the sensed context. A collection of such things can form what we call a thing-ensemble, when they have the ability to communicate with one another (over a short range network such as Bluetooth, or the Internet, i.e. the Internet of Things (IoT concept, sense each other, and when each of them might play certain roles with respect to each other. Each smart thing in a thing-ensemble might have its own context-aware behaviours which when integrated with other smart things yield behaviours that are not straightforward to reason with. We present Sigma, a language of operators, inspired from modular logic programming, for specifying and reasoning with combined behaviours among smart things in a thing-ensemble. We show numerous examples of the use of Sigma for describing a range of behaviours over a diverse range of thing-ensembles, from sensor networks to smart digital frames, demonstrating the versatility of our approach. We contend that our operator approach abstracts away low-level communication and protocol details, and allows systems of context-aware things to be designed and built in a compositional and incremental manner.

  10. Community vs. Clinic-based modular treatment of children with early-onset ODD or CD: A clinical trial with 3-year follow-up

    Science.gov (United States)

    Kolko, David J.; Bukstein, Oscar G.; Padini, Dustin; Holden, Elizabeth A.; Hart, Jonathan; Dorn, Lorah D.

    2016-01-01

    This study examines the treatment outcomes of 144, 6–11 year-old, clinically referred boys and girls diagnosed with Oppositional Defiant Disorder (ODD) or Conduct Disorder (CD) who were randomly assigned to a modular-based treatment protocol that was applied by research study clinicians either in the community (COMM) or a clinic office (CLINIC). To examine normative comparisons, a matched sample of 69 healthy control children was included. Multiple informants completed diagnostic interviews and self-reports at six assessment timepoints (pretreatment to 3-year follow-up) to evaluate changes in the child’s behavioral and emotional problems, psychopathic features, functional impairment, diagnostic status, and service involvement. Using HLM and logistic regression models, COMM and CLINIC showed significant and comparable improvements on all outcomes. By 3-year follow-up, 36% of COMM and 47% of CLINIC patients no longer met criteria for either ODD or CD, and 48% and 57% of the children in these two respective conditions had levels of parent-rated externalizing behavior problems in the normal range. We discuss the nature and implications of these novel findings regarding the role of treatment context or setting for the treatment and long-term outcome of behavior disorders. PMID:19221871

  11. Magnetohydrodynamic-based Laboratories on a Chip for Analysis of Biomolecules Project

    Data.gov (United States)

    National Aeronautics and Space Administration — A laboratory-on-a-chip design based on magnetohydrodynamic (MHD) microfluidics and integrated microelectrochemical detection is proposed. The proposed device is...

  12. Towards Versatile Robots Through Open Heterogeneous Modular Robots

    DEFF Research Database (Denmark)

    Lyder, Andreas

    Robots are important tools in our everyday life. Both in industry and at the consumer level they serve the purpose of increasing our scope and extending our capabilities. Modular robots take the next step, allowing us to easily create and build various robots from a set of modules. If a problem...... arises, a new robot can be assembled rapidly from the existing modules, in contrast to conventional robots, which require a time consuming and expensive development process. In this thesis we define a modular robot to be a robot consisting of dynamically reconfigurable modules. The goal of this thesis...... is to increase the versatility and practical usability of modular robots by introducing new conceptual designs. Until now modular robots have been based on a pre-specified set of modules, and thus, their functionality is limited. We propose an open heterogeneous design concept, which allows a modular robot...

  13. Laboratory based degradation of light crude oil by aquatic ...

    African Journals Online (AJOL)

    Water samples were collected from Dundaye river (an offshoot of sokoto river Rima) using sterile conical flasks. The samples were immediately transported to the Microbiology Laboratory and introduced into petri dishes containing hemp seeds ( Crotalaria juncea) and allowed to stand on the bench. The hemp seeds served ...

  14. Differentiating Biochemistry Course Laboratories Based on Student Experience

    Science.gov (United States)

    Jakubowski, Henry V.

    2011-01-01

    Content and emphases in undergraduate biochemistry courses can be readily tailored to accommodate the standards of the department in which they are housed, as well as the backgrounds of the students in the courses. A more challenging issue is how to construct laboratory experiences for a class with both chemistry majors, who usually have little or…

  15. Development of a Green Fluorescent Protein-Based Laboratory Curriculum

    Science.gov (United States)

    Larkin, Patrick D.; Hartberg, Yasha

    2005-01-01

    A laboratory curriculum has been designed for an undergraduate biochemistry course that focuses on the investigation of the green fluorescent protein (GFP). The sequence of procedures extends from analysis of the DNA sequence through PCR amplification, recombinant plasmid DNA synthesis, bacterial transformation, expression, isolation, and…

  16. Laboratory based degradation of light crude oil by aquatic ...

    African Journals Online (AJOL)

    STORAGESEVER

    2009-08-18

    Aug 18, 2009 ... Water samples were collected from Dundaye river (an offshoot of sokoto river Rima) using sterile conical flasks. The samples were immediately transported to the Microbiology Laboratory and introduced into petri dishes containing hemp seeds (Crotalaria juncea) and allowed to stand on the bench.

  17. Model engineering in a modular PSA

    International Nuclear Information System (INIS)

    Friedlhuber, Thomas

    2014-01-01

    developed at EDF R and D to test and evaluate the concepts around a modular PSA. Andromeda is based on a modular and extensible architecture that can be customized to specific needs of customers. Apart from research interest, it has recently gained industrial interest. Andromeda has potential to complete existing PSA tools by specific functionality and to enforce the international PSA community around common modeling standards and techniques. (author)

  18. Robotic hand with modular extensions

    Science.gov (United States)

    Salisbury, Curt Michael; Quigley, Morgan

    2015-01-20

    A robotic device is described herein. The robotic device includes a frame that comprises a plurality of receiving regions that are configured to receive a respective plurality of modular robotic extensions. The modular robotic extensions are removably attachable to the frame at the respective receiving regions by way of respective mechanical fuses. Each mechanical fuse is configured to trip when a respective modular robotic extension experiences a predefined load condition, such that the respective modular robotic extension detaches from the frame when the load condition is met.

  19. Data integrity by validation of a computer based laboratory system

    OpenAIRE

    Jasmin, Ramić

    2017-01-01

    The thesis deals with the assurance of regulatory compliance and validation of computer supported laboratory systems in the pharmaceutical industry. It describes the functioning and importance of regulatory authorities and explains the standards and good practice examples to be observed in the validation process. By actively introducing the act on electronic records and signatures, food and drug agencies have succeeded in setting up clear requirements and guidelines in the pharmaceutical indu...

  20. Enhancing laboratory activity with computer-based tutorials

    OpenAIRE

    Gordon Ritchie; Paul Garner

    1995-01-01

    In a degree course in electronic engineering, great importance is attached to laboratory work, in which students have the opportunity to develop their creative skills in a practical environment. For example, in the first year of the course they are expected to design and test some basic circuits using data available on the characteristics of the semiconductor devices to be used. Many of the students cannot be prepared sufficiently for this activity by attendance at lectures, in which basic pr...

  1. Bio-based production of fuels and industrial chemicals by repurposing antibiotic-producing type I modular polyketide synthases: opportunities and challenges

    Energy Technology Data Exchange (ETDEWEB)

    Yuzawa, Satoshi [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Systems and Engineering Division; Keasling, Jay D. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Systems and Engineering Division; Univ. of California, Berkeley, CA (United States). QB3 Inst.; Joint BioEnergy Inst. (JBEI), Emeryville, CA (United States); Univ. of California, Berkeley, CA (United States). Dept. of Bioengineering; Univ. of California, Berkeley, CA (United States). Dept. of Chemical and Biomolecular Engineering; Technical Univ. of Denmark, Horsholm (Denmark). Novo Nordisk Foundation Center for Biosustainability; Katz, Leonard [Univ. of California, Berkeley, CA (United States). QB3 Inst.

    2016-11-16

    Complex polyketides comprise a large number of natural products that have broad application in medicine and agriculture. They are produced in bacteria and fungi from large enzyme complexes named type I modular polyketide synthases (PKSs) that are composed of multifunctional polypeptides containing discrete enzymatic domains organized into modules. The modular nature of PKSs has enabled a multitude of efforts to engineer the PKS genes to produce novel polyketides of predicted structure. Finally, we have repurposed PKSs to produce a number of short-chain mono- and di-carboxylic acids and ketones that could have applications as fuels or industrial chemicals.

  2. Bio-based production of fuels and industrial chemicals by repurposing antibiotic-producing type I modular polyketide synthases: opportunities and challenges.

    Science.gov (United States)

    Yuzawa, Satoshi; Keasling, Jay D; Katz, Leonard

    2017-04-01

    Complex polyketides comprise a large number of natural products that have broad application in medicine and agriculture. They are produced in bacteria and fungi from large enzyme complexes named type I modular polyketide synthases (PKSs) that are composed of multifunctional polypeptides containing discrete enzymatic domains organized into modules. The modular nature of PKSs has enabled a multitude of efforts to engineer the PKS genes to produce novel polyketides of predicted structure. We have repurposed PKSs to produce a number of short-chain mono- and di-carboxylic acids and ketones that could have applications as fuels or industrial chemicals.

  3. Bio-based production of fuels and industrial chemicals by repurposing antibiotic-producing type I modular polyketide synthases: opportunities and challenges

    DEFF Research Database (Denmark)

    Yuzawa, Satoshi; Keasling, Jay D.; Katz, Leonard

    2017-01-01

    Complex polyketides comprise a large number of natural products that have broad application in medicine and agriculture. They are produced in bacteria and fungi from large enzyme complexes named type I modular polyketide synthases (PKSs) that are composed of multifunctional polypeptides containing...... discrete enzymatic domains organized into modules. The modular nature of PKSs has enabled a multitude of efforts to engineer the PKS genes to produce novel polyketides of predicted structure. We have repurposed PKSs to produce a number of short-chain mono- and di-carboxylic acids and ketones that could...

  4. A modular restoration tower for electric power line transmission

    Energy Technology Data Exchange (ETDEWEB)

    Nicolazzi, L.C.; Pereira, J.C.; Leonel, C.E.L.; Rocha, G.B.; Bianchezzi, V.; Mendes, F. [Universidade Federal Santa Catarina (UFSC), Florianopolis, SC (Brazil). Dept. de Engenharia Mecanica], Emails: lauro@grante.ufsc.br, jcarlos@grante.ufsc.br; Luz, R.L. [ELETROSUL Centrais Eletricas S.A., Florianopolis, SC (Brazil)], Email: rluz@eletrosul.gov.br

    2009-07-01

    The main target of this R and D project is to develop an restoration tower for electric energy lines transmission. Whereas these towers should present the main features like transport facility, easiest assembling associated with a low cost of manufacture, it was applied the single-column tower concepts supported by stays, modularized, framed and articulated at the base. The concepts used for this development was a design methodology. From the different definition situations of load, numerical models have been developed focusing the design to the best of structural element arrangements of its modules. Then, tests were performed in laboratory to determine the module structural performance for different work load situations. These tests served to identify inconsistencies in the numerical models and proposed adjustments in its design to improve its performance on the strength and stability. (author)

  5. Modular Mobile Application Design

    Directory of Open Access Journals (Sweden)

    Jim Hahn

    2012-10-01

    Full Text Available This article describes the development of the Minrva library app for Android phones. The decisions to build a native application with Java and use a modular design are discussed. The application includes five modules: catalog search, in-building navigation, a barcode scanning feature, and up to date notifications of circulating technology availability. A sixth module, Amazon recommendations, that is not included in the version of the app that was released is also discussed. The article also reports on the findings of two rounds of usability testing and the plans for future development of the app.

  6. Development of a composite large-size SiPM (assembled matrix) based modular detector cluster for MAGIC

    Energy Technology Data Exchange (ETDEWEB)

    Hahn, A., E-mail: ahahn@mpp.mpg.de [Max Planck Institute for Physics (Werner-Heisenberg-Institut), Föhringer Ring 6, 80805 München (Germany); Mazin, D., E-mail: mazin@mpp.mpg.de [Max Planck Institute for Physics (Werner-Heisenberg-Institut), Föhringer Ring 6, 80805 München (Germany); Institute for Cosmic Ray Research, The University of Tokyo, 5-1-5 Kashiwa-no-Ha, Kashiwa City, Chiba 277–8582 (Japan); Bangale, P., E-mail: priya@mpp.mpg.de [Max Planck Institute for Physics (Werner-Heisenberg-Institut), Föhringer Ring 6, 80805 München (Germany); Dettlaff, A., E-mail: todettl@mpp.mpg.de [Max Planck Institute for Physics (Werner-Heisenberg-Institut), Föhringer Ring 6, 80805 München (Germany); Fink, D., E-mail: fink@mpp.mpg.de [Max Planck Institute for Physics (Werner-Heisenberg-Institut), Föhringer Ring 6, 80805 München (Germany); Grundner, F., E-mail: grundner@mpp.mpg.de [Max Planck Institute for Physics (Werner-Heisenberg-Institut), Föhringer Ring 6, 80805 München (Germany); Haberer, W., E-mail: haberer@mpp.mpg.de [Max Planck Institute for Physics (Werner-Heisenberg-Institut), Föhringer Ring 6, 80805 München (Germany); Maier, R., E-mail: rma@mpp.mpg.de [Max Planck Institute for Physics (Werner-Heisenberg-Institut), Föhringer Ring 6, 80805 München (Germany); and others

    2017-02-11

    The MAGIC collaboration operates two 17 m diameter Imaging Atmospheric Cherenkov Telescopes (IACTs) on the Canary Island of La Palma. Each of the two telescopes is currently equipped with a photomultiplier tube (PMT) based imaging camera. Due to the advances in the development of Silicon Photomultipliers (SiPMs), they are becoming a widely used alternative to PMTs in many research fields including gamma-ray astronomy. Within the Otto-Hahn group at the Max Planck Institute for Physics, Munich, we are developing a SiPM based detector module for a possible upgrade of the MAGIC cameras and also for future experiments as, e.g., the Large Size Telescopes (LST) of the Cherenkov Telescope Array (CTA). Because of the small size of individual SiPM sensors (6 mm×6 mm) with respect to the 1-inch diameter PMTs currently used in MAGIC, we use a custom-made matrix of SiPMs to cover the same detection area. We developed an electronic circuit to actively sum up and amplify the SiPM signals. Existing non-imaging hexagonal light concentrators (Winston cones) used in MAGIC have been modified for the angular acceptance of the SiPMs by using C++ based ray tracing simulations. The first prototype based detector module includes seven channels and was installed into the MAGIC camera in May 2015. We present the results of the first prototype and its performance as well as the status of the project and discuss its challenges. - Highlights: • The design of the first SiPM large-size IACT pixel is described. • The simulation of the light concentrators is presented. • The temperature stability of the detector module is demonstrated. • The calibration procedure of SiPM device in the field is described.

  7. Rapid and simple detection of foot-and-mouth disease virus: Evaluation of a cartridge-based molecular detection system for use in basic laboratories.

    Science.gov (United States)

    Goller, K V; Dill, V; Madi, M; Martin, P; Van der Stede, Y; Vandenberge, V; Haas, B; Van Borm, S; Koenen, F; Kasanga, C J; Ndusilo, N; Beer, M; Liu, L; Mioulet, V; Armson, B; King, D P; Fowler, V L

    2018-04-01

    Highly contagious transboundary animal diseases such as foot-and-mouth disease (FMD) are major threats to the productivity of farm animals. To limit the impact of outbreaks and to take efficient steps towards a timely control and eradication of the disease, rapid and reliable diagnostic systems are of utmost importance. Confirmatory diagnostic assays are typically performed by experienced operators in specialized laboratories, and access to this capability is often limited in the developing countries with the highest disease burden. Advances in molecular technologies allow implementation of modern and reliable techniques for quick and simple pathogen detection either in basic laboratories or even at the pen-side. Here, we report on a study to evaluate a fully automated cartridge-based real-time RT-PCR diagnostic system (Enigma MiniLab ® ) for the detection of FMD virus (FMDV). The modular system integrates both nucleic acid extraction and downstream real-time RT-PCR (rRT-PCR). The analytical sensitivity of this assay was determined using serially diluted culture grown FMDV, and the performance of the assay was evaluated using a selected range of FMDV positive and negative clinical samples of bovine, porcine and ovine origin. The robustness of the assay was evaluated in an international inter-laboratory proficiency test and by deployment into an African laboratory. It was demonstrated that the system is easy to use and can detect FMDV with high sensitivity and specificity, roughly on par with standard laboratory methods. This cartridge-based automated real-time RT-PCR system for the detection of FMDV represents a reliable and easy to use diagnostic tool for the early and rapid disease detection of acutely infected animals even in remote areas. This type of system could be easily deployed for routine surveillance within endemic regions such as Africa or could alternatively be used in the developed world. © 2017 The Authors. Transboundary and Emerging Diseases

  8. QCloud: A cloud-based quality control system for mass spectrometry-based proteomics laboratories.

    Science.gov (United States)

    Chiva, Cristina; Olivella, Roger; Borràs, Eva; Espadas, Guadalupe; Pastor, Olga; Solé, Amanda; Sabidó, Eduard

    2018-01-01

    The increasing number of biomedical and translational applications in mass spectrometry-based proteomics poses new analytical challenges and raises the need for automated quality control systems. Despite previous efforts to set standard file formats, data processing workflows and key evaluation parameters for quality control, automated quality control systems are not yet widespread among proteomics laboratories, which limits the acquisition of high-quality results, inter-laboratory comparisons and the assessment of variability of instrumental platforms. Here we present QCloud, a cloud-based system to support proteomics laboratories in daily quality assessment using a user-friendly interface, easy setup, automated data processing and archiving, and unbiased instrument evaluation. QCloud supports the most common targeted and untargeted proteomics workflows, it accepts data formats from different vendors and it enables the annotation of acquired data and reporting incidences. A complete version of the QCloud system has successfully been developed and it is now open to the proteomics community (http://qcloud.crg.eu). QCloud system is an open source project, publicly available under a Creative Commons License Attribution-ShareAlike 4.0.

  9. Modular Ultra-High Power Solar Array Architecture, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Deployable Space Systems (DSS) will focus the proposed Phase 2 SBIR program on the hardware-based development and TRL advance of a highly-modularized and...

  10. Modular Spray-Cooled Assemblies for High Heat Fluxes Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This NASA SBIR Phase II project will produce a flight suitable test bench based on a modular spray-cooled assembly that considers NASA power and mass budgets and can...

  11. Modular and reconfigurable common PCB-platform of FPGA based LLRF control system for TESLA test facility

    International Nuclear Information System (INIS)

    Pozniak, K.T.; Romaniuk, R.S.; Kierzkowski, K.

    2005-01-01

    The paper includes a description of predicted functionalities to be implemented in a universal motherboard (MB) for the next generation of LLRF control system for TESLA. The motherboard bases on a number of quasi-autonomous embedded executive modules. The modules are implemented in a few FPGA chips featured by the MB. The paper presents a practical design of the MB. The initial (basic) solution of the MB has the Cyclone as the chip where the board management is embedded. The board features communication modules - VME and micro, single chip PC with Ethernet. The board provides power supply for the FPGA chips. The board has fast internal communication between particular modules. (orig.)

  12. Modular and reconfigurable common PCB-platform of FPGA based LLRF control system for TESLA test facility

    Energy Technology Data Exchange (ETDEWEB)

    Pozniak, K.T.; Romaniuk, R.S. [Institute of Electronic Systems, Warsaw (Poland); Kierzkowski, K. [Institute of Experimental Physics, Warsaw (Poland)

    2005-07-01

    The paper includes a description of predicted functionalities to be implemented in a universal motherboard (MB) for the next generation of LLRF control system for TESLA. The motherboard bases on a number of quasi-autonomous embedded executive modules. The modules are implemented in a few FPGA chips featured by the MB. The paper presents a practical design of the MB. The initial (basic) solution of the MB has the Cyclone as the chip where the board management is embedded. The board features communication modules - VME and micro, single chip PC with Ethernet. The board provides power supply for the FPGA chips. The board has fast internal communication between particular modules. (orig.)

  13. Activity-Based Introductory Physics Using Graphing Calculators and Calculator-Based Laboratories (CBLs)*

    Science.gov (United States)

    Trecia Markes, C.

    1998-04-01

    This paper will report on the development of an activity-based approach to teaching introductory physics that makes extensive use of the Calculator-Based Laboratory (CBL) system from Texas Instruments to collect and analyze data. Studies have suggested that an activity-based instruction format and computer-implemented data acquisition and analysis are effective in enhancing teaching effectiveness. However, implementation of this kind of class is accompanied by significant financial, spatial, and portability constraints. The TI-85/92 graphing calculators provide sufficient computational capacity and speed to handle most of the data acquisition and analysis requirements found in activity based introductory physics instruction. This paper will show how some physical laws can be derived from data obtained using the calculator/CBL system. Other data that can be easily obtained will also be shown and discussed. Results of pre-test and post-test given to both activity-based sections and lecture/laboratory sectioons of algebra-level introductory physics classes will also be discussed.

  14. Modular Robotic Vehicle

    Science.gov (United States)

    Borroni-Bird, Christopher E. (Inventor); Vitale, Robert L. (Inventor); Lee, Chunhao J. (Inventor); Ambrose, Robert O. (Inventor); Bluethmann, William J. (Inventor); Junkin, Lucien Q. (Inventor); Lutz, Jonathan J. (Inventor); Guo, Raymond (Inventor); Lapp, Anthony Joseph (Inventor); Ridley, Justin S. (Inventor)

    2015-01-01

    A modular robotic vehicle includes a chassis, driver input devices, an energy storage system (ESS), a power electronics module (PEM), modular electronic assemblies (eModules) connected to the ESS via the PEM, one or more master controllers, and various embedded controllers. Each eModule includes a drive wheel containing a propulsion-braking module, and a housing containing propulsion and braking control assemblies with respective embedded propulsion and brake controllers, and a mounting bracket covering a steering control assembly with embedded steering controllers. The master controller, which is in communication with each eModule and with the driver input devices, communicates with and independently controls each eModule, by-wire, via the embedded controllers to establish a desired operating mode. Modes may include a two-wheel, four-wheel, diamond, and omni-directional steering modes as well as a park mode. A bumper may enable docking with another vehicle, with shared control over the eModules of the vehicles.

  15. SSPM based radiation sensing: Preliminary laboratory and clinical results

    International Nuclear Information System (INIS)

    Konnoff, Daniel C.; Plant, Thomas K.; Shiner, Elizabeth

    2011-01-01

    Recent Solid State Photomultiplier (SSPM) technology has matured, reaching a performance level that is suitable for replacement of the ubiquitous photomultiplier tube in selected applications for environmental radiation monitoring, clinical dosimetry, and medical imaging purposes. The objective of this work is low signal level laboratory and high signal level clinical testing of the Hamamatsu MPPC (S10362-11-050C), Photonique SSPM (0810G1), and Voxtel SiPM (SQBF-EKAA/SQBF-EIOA) SSPMs coupled to different inorganic scintillator crystals (Prelude 420, BGO), inorganic doped glass scintillator material SiO 2 :Cu 2+ and organic BCF-12 plastic scintillating fibers, used as detector elements. Plastic Optical Fibers (POFs) and Glass Optical Fibers (GOFs) are used as signal conduits for laboratory and clinical testing. Further, reduction of electron-beam-generated Cerenkov light in optical fibers is facilitated by the inclusion of metalized air-core capillary tubing between the BCF-12 plastic scintillating fiber and the POF. In a clinical setting dose linearity, percent depth dose, and angular measurements for 6 MV/18 MV photon beams and 9 MeV electron beams are compared with and without the use of the air-core capillary tubing for BCF-12 plastic scintillating fiber. These same measurements are repeated for SiO 2 :Cu 2+ scintillator material without air-core capillary tubing.

  16. Application and development analysis of nuclear power plant modular construction

    International Nuclear Information System (INIS)

    Fang Xiaopeng

    2015-01-01

    Modular Construction is currently one of the major development trends for the nuclear power plant construction technology worldwide. In the first-of-a-kind AP1000 Nuclear Power Project practiced in China, the large-scale structural modules and mechanical modules have been successfully fabricated, assembled and installed. However, in the construction practice of the project, some quality issues are identified with the assembly and installation process of large-scale structural modules in addition to the issue of incomplete supply of mechanical modules, which has failed to fully demonstrate the features and merits of modular construction. This paper collects and consolidates the issues of modular construction of AP1000 first of a kind reactor, providing root cause analysis in the aspects of process design, quality control, site construction logic, interface management in the process of module fabrication, assembly and installation; modular construction feasibility assessment index is proved based on the quantification and qualitative analysis of the impact element. Based on the modular construction feasibility, NPP modular construction improvement suggestions are provided in the aspect of modular assembly optimization definition, tolerance control during the fitting process and the construction logic adjustment. (author)

  17. MODULAR MANIPULATOR FOR ROBOTICS APPLICATIONS

    Energy Technology Data Exchange (ETDEWEB)

    Joseph W. Geisinger, Ph.D.

    2001-07-31

    ARM Automation, Inc. is developing a framework of modular actuators that can address the DOE's wide range of robotics needs. The objective of this effort is to demonstrate the effectiveness of this technology by constructing a manipulator from these actuators within a glovebox for Automated Plutonium Processing (APP). At the end of the project, the system of actuators was used to construct several different manipulator configurations, which accommodate common glovebox tasks such as repackaging. The modular nature and quickconnects of this system simplify installation into ''hot'' boxes and any potential modifications or repair therein. This work focused on the development of self-contained robotic actuator modules including the embedded electronic controls for the purpose of building a manipulator system. Both of the actuators developed under this project contain the control electronics, sensors, motor, gear train, wiring, system communications and mechanical interfaces of a complete robotics servo device. Test actuators and accompanying DISC{trademark}s underwent validation testing at The University of Texas at Austin and ARM Automation, Inc. following final design and fabrication. The system also included custom links, an umbilical cord, an open architecture PC-based system controller, and operational software that permitted integration into a completely functional robotic manipulator system. The open architecture on which this system is based avoids proprietary interfaces and communication protocols which only serve to limit the capabilities and flexibility of automation equipment. The system was integrated and tested in the contractor's facility for intended performance and operations. The manipulator was tested using the full-scale equipment and process mock-ups. The project produced a practical and operational system including a quantitative evaluation of its performance and cost.

  18. MODULAR MANIPULATOR FOR ROBOTICS APPLICATIONS

    International Nuclear Information System (INIS)

    Geisinger, Joseph W. Ph.D.

    2001-01-01

    ARM Automation, Inc. is developing a FR-amework of modular actuators that can address the DOE's wide range of robotics needs. The objective of this effort is to demonstrate the effectiveness of this technology by constructing a manipulator FR-om these actuators within a glovebox for Automated Plutonium Processing (APP). At the end of the project, the system of actuators was used to construct several different manipulator configurations, which accommodate common glovebox tasks such as repackaging. The modular nature and quickconnects of this system simplify installation into ''hot'' boxes and any potential modifications or repair therein. This work focused on the development of self-contained robotic actuator modules including the embedded electronic controls for the purpose of building a manipulator system. Both of the actuators developed under this project contain the control electronics, sensors, motor, gear train, wiring, system communications and mechanical interfaces of a complete robotics servo device. Test actuators and accompanying DISC(trademark)s underwent validation testing at The University of Texas at Austin and ARM Automation, Inc. following final design and fabrication. The system also included custom links, an umbilical cord, an open architecture PC-based system controller, and operational software that permitted integration into a completely functional robotic manipulator system. The open architecture on which this system is based avoids proprietary interfaces and communication protocols which only serve to limit the capabilities and flexibility of automation equipment. The system was integrated and tested in the contractor's facility for intended performance and operations. The manipulator was tested using the full-scale equipment and process mock-ups. The project produced a practical and operational system including a quantitative evaluation of its performance and cost

  19. Fable: Socially Interactive Modular Robot

    DEFF Research Database (Denmark)

    Magnússon, Arnþór; Pacheco, Moises; Moghadam, Mikael

    2013-01-01

    Modular robots have a significant potential as user-reconfigurable robotic playware, but often lack sufficient sensing for social interaction. We address this issue with the Fable modular robotic system by exploring the use of smart sensor modules that has a better ability to sense the behavior...

  20. Modular Decomposition of Boolean Functions

    NARCIS (Netherlands)

    J.C. Bioch (Cor)

    2002-01-01

    textabstractModular decomposition is a thoroughly investigated topic in many areas such as switching theory, reliability theory, game theory and graph theory. Most appli- cations can be formulated in the framework of Boolean functions. In this paper we give a uni_ed treatment of modular

  1. The Modular Design and Production of an Intelligent Robot Based on a Closed-Loop Control Strategy.

    Science.gov (United States)

    Zhang, Libo; Zhu, Junjie; Ren, Hao; Liu, Dongdong; Meng, Dan; Wu, Yanjun; Luo, Tiejian

    2017-10-14

    Intelligent robots are part of a new generation of robots that are able to sense the surrounding environment, plan their own actions and eventually reach their targets. In recent years, reliance upon robots in both daily life and industry has increased. The protocol proposed in this paper describes the design and production of a handling robot with an intelligent search algorithm and an autonomous identification function. First, the various working modules are mechanically assembled to complete the construction of the work platform and the installation of the robotic manipulator. Then, we design a closed-loop control system and a four-quadrant motor control strategy, with the aid of debugging software, as well as set steering gear identity (ID), baud rate and other working parameters to ensure that the robot achieves the desired dynamic performance and low energy consumption. Next, we debug the sensor to achieve multi-sensor fusion to accurately acquire environmental information. Finally, we implement the relevant algorithm, which can recognize the success of the robot's function for a given application. The advantage of this approach is its reliability and flexibility, as the users can develop a variety of hardware construction programs and utilize the comprehensive debugger to implement an intelligent control strategy. This allows users to set personalized requirements based on their needs with high efficiency and robustness.

  2. An Introductory Laboratory Exercise for Acids and Bases.

    Science.gov (United States)

    Miller, Richard; Silberman, Robert

    1986-01-01

    Discusses an acid-base neutralization exercise requiring groups of students to determine: (1) combinations of solutions giving neutralization; (2) grouping solutions as acids or bases; and (3) ranking groups in order of concentration. (JM)

  3. The use of virtual laboratories and other web-based tools in a drug assay course.

    Science.gov (United States)

    Dunham, Marissa Waldman; Ghirtis, Konstantine; Beleh, Mustapha

    2012-06-18

    To determine students' perceptions of and performance in a drug assay laboratory course after the addition of Web-based multimedia tools. Video modules and other Web-based tools to deliver instructions and emulate the laboratory set up for experiments were implemented in 2005 to improve student preparation for laboratory sessions and eliminate the need for graduate students to present instructions live. Data gathered from quizzes, final examinations, and post-course surveys administered over 6 years were analyzed. Students' scores on online quizzes after implementation of the virtual laboratories reflected improved student understanding and preparation. Students' perception of the course improved significantly after the introduction of the tools and the new teaching model. Implementation of an active-learning model in a laboratory course led to improvement in students' educational experience and satisfaction. Additional benefits included improved resource use, student exposure to a variety of educational methods, and having a highly structured laboratory format that reduced inconsistencies in delivered instructions.

  4. Laser-plasma-based Space Radiation Reproduction in the Laboratory.

    Science.gov (United States)

    Hidding, B; Karger, O; Königstein, T; Pretzler, G; Manahan, G G; McKenna, P; Gray, R; Wilson, R; Wiggins, S M; Welsh, G H; Beaton, A; Delinikolas, P; Jaroszynski, D A; Rosenzweig, J B; Karmakar, A; Ferlet-Cavrois, V; Costantino, A; Muschitiello, M; Daly, E

    2017-02-08

    Space radiation is a great danger to electronics and astronauts onboard space vessels. The spectral flux of space electrons, protons and ions for example in the radiation belts is inherently broadband, but this is a feature hard to mimic with conventional radiation sources. Using laser-plasma-accelerators, we reproduced relativistic, broadband radiation belt flux in the laboratory, and used this man-made space radiation to test the radiation hardness of space electronics. Such close mimicking of space radiation in the lab builds on the inherent ability of laser-plasma-accelerators to directly produce broadband Maxwellian-type particle flux, akin to conditions in space. In combination with the established sources, utilisation of the growing number of ever more potent laser-plasma-accelerator facilities worldwide as complementary space radiation sources can help alleviate the shortage of available beamtime and may allow for development of advanced test procedures, paving the way towards higher reliability of space missions.

  5. Computer-based laboratory simulation: evaluations of student perceptions

    Directory of Open Access Journals (Sweden)

    Norrie S. Edward

    1996-12-01

    Full Text Available Laboratory experimentation in engineering is an essential part of the three main components in an engineer's formation. The theoretical constructs and models are imparted in lectures and tutorials. Workshop hands-on activity allows the student to acquire an understanding of the interaction of design and manufacture, and the constraints both impose. Characteristics of plant are investigated through experiment, and this aids the learner's understanding of the limitation of models in predicting performance. The learner also gains an appreciation of the nature of errors and of the construction of plant. But while the oil industry has brought prosperity to the North- East, it has also brought unique educational demands: the working arrangements place severe restrictions on part-time student attendance. Technicians work a block of two to four weeks offshore, followed by a similar period of leave. Different companies have different arrangements, and shift-change days.

  6. Rapid automation of a cell-based assay using a modular approach: case study of a flow-based Varicella Zoster Virus infectivity assay.

    Science.gov (United States)

    Joelsson, Daniel; Gates, Irina V; Pacchione, Diana; Wang, Christopher J; Bennett, Philip S; Zhang, Yuhua; McMackin, Jennifer; Frey, Tina; Brodbeck, Kristin C; Baxter, Heather; Barmat, Scott L; Benetti, Luca; Bodmer, Jean-Luc

    2010-06-01

    Vaccine manufacturing requires constant analytical monitoring to ensure reliable quality and a consistent safety profile of the final product. Concentration and bioactivity of active components of the vaccine are key attributes routinely evaluated throughout the manufacturing cycle and for product release and dosage. In the case of live attenuated virus vaccines, bioactivity is traditionally measured in vitro by infection of susceptible cells with the vaccine followed by quantification of virus replication, cytopathology or expression of viral markers. These assays are typically multi-day procedures that require trained technicians and constant attention. Considering the need for high volumes of testing, automation and streamlining of these assays is highly desirable. In this study, the automation and streamlining of a complex infectivity assay for Varicella Zoster Virus (VZV) containing test articles is presented. The automation procedure was completed using existing liquid handling infrastructure in a modular fashion, limiting custom-designed elements to a minimum to facilitate transposition. In addition, cellular senescence data provided an optimal population doubling range for long term, reliable assay operation at high throughput. The results presented in this study demonstrate a successful automation paradigm resulting in an eightfold increase in throughput while maintaining assay performance characteristics comparable to the original assay. Copyright 2010 Elsevier B.V. All rights reserved.

  7. China general nuclear power corporation--The recent research and application of the modular technology in nuclear power engineering

    International Nuclear Information System (INIS)

    Lu Qinwu

    2014-01-01

    Modular design and construction is one of the distinctive features of the 3 rd generation nuclear power technology. In order to promote the technological innovations in nuclear power engineering design and construction and develop the self-owned modular technology, China General Nuclear Power Corporation (CGN) has carried out the R and D and application of the modular technology based on the CPR1000-type nuclear power plants, and has made the national-level achievements in the establishment of modular design technology system, development of 3D modular design system and application of modular construction of containment steel liner in the demonstration projects. (author)

  8. Modular and efficient ozone systems based on massively parallel chemical processing in microchannel plasma arrays: performance and commercialization

    Science.gov (United States)

    Kim, M.-H.; Cho, J. H.; Park, S.-J.; Eden, J. G.

    2017-08-01

    Plasmachemical systems based on the production of a specific molecule (O3) in literally thousands of microchannel plasmas simultaneously have been demonstrated, developed and engineered over the past seven years, and commercialized. At the heart of this new plasma technology is the plasma chip, a flat aluminum strip fabricated by photolithographic and wet chemical processes and comprising 24-48 channels, micromachined into nanoporous aluminum oxide, with embedded electrodes. By integrating 4-6 chips into a module, the mass output of an ozone microplasma system is scaled linearly with the number of modules operating in parallel. A 115 g/hr (2.7 kg/day) ozone system, for example, is realized by the combined output of 18 modules comprising 72 chips and 1,800 microchannels. The implications of this plasma processing architecture for scaling ozone production capability, and reducing capital and service costs when introducing redundancy into the system, are profound. In contrast to conventional ozone generator technology, microplasma systems operate reliably (albeit with reduced output) in ambient air and humidity levels up to 90%, a characteristic attributable to the water adsorption/desorption properties and electrical breakdown strength of nanoporous alumina. Extensive testing has documented chip and system lifetimes (MTBF) beyond 5,000 hours, and efficiencies >130 g/kWh when oxygen is the feedstock gas. Furthermore, the weight and volume of microplasma systems are a factor of 3-10 lower than those for conventional ozone systems of comparable output. Massively-parallel plasmachemical processing offers functionality, performance, and commercial value beyond that afforded by conventional technology, and is currently in operation in more than 30 countries worldwide.

  9. A Comparison of Students' Approaches to Inquiry, Conceptual Learning, and Attitudes in Simulation-Based and Microcomputer-Based Laboratories

    Science.gov (United States)

    Chen, Sufen; Chang, Wen-Hua; Lai, Chih-Hung; Tsai, Cheng-Yue

    2014-01-01

    The purpose of this project was to investigate the effects of virtual versus physical manipulation using a simulation-based laboratory activity (SBL) and a microcomputer-based laboratory activity (MBL). Both the SBL and the MBL used computers to collect, graph, and analyze data. A major difference was that the MBL allowed the students to…

  10. Solution Concept of Modular Single Phase Active Power Filters

    Directory of Open Access Journals (Sweden)

    Marek Roch

    2006-01-01

    Full Text Available This paper investigates a modular or a decentralised single-phase active power filter control strategy. It is based on the evaluation of the harmonic reference load currents for the active power filter blocks operating under specific harmonic frequencies. The underlying principle of the modular active power filter is explained and it is shown how the required reference harmonic currents can be evaluated. Simulation results demonstrated the improvement in the dynamic performance of the modular active power filter presented here in comparison with the conventional type.

  11. INFORMATION SECURITY IN MOBILE MODULAR MEASURING SYSTEMS

    Directory of Open Access Journals (Sweden)

    A. N. Tkhishev

    2017-01-01

    Full Text Available A special aspect of aircraft test is carrying out both flight evaluation and ground operation evaluation in a structure of flying aids and special tools equipment. The specific of flight and sea tests involve metering in offshore zone, which excludes the possibility of fixed geodetically related measuring tools. In this regard, the specific role is acquired by shipbased measurement systems, in particular the mobile modular measuring systems. Information processed in the mobile modular measurement systems is a critical resource having a high level of confidentiality. When carrying out their functions, it should be implemented a proper information control of the mobile modular measurement systems to ensure their protection from the risk of data leakage, modification or loss, i.e. to ensure a certain level of information security. Due to the specific of their application it is difficult to solve the problems of information security in such complexes. The intruder model, the threat model, the security requirements generated for fixed informatization objects are not applicable to mobile systems. It was concluded that the advanced mobile modular measuring systems designed for flight experiments monitoring and control should be created due to necessary information protection measures and means. The article contains a diagram of security requirements formation, starting with the data envelopment analysis and ending with the practical implementation. The information security probabilistic model applied to mobile modular measurement systems is developed. The list of current security threats based on the environment and specific of the mobile measurement system functioning is examined. The probabilistic model of the information security evaluation is given. The problems of vulnerabilities transformation of designed information system into the security targets with the subsequent formation of the functional and trust requirements list are examined.

  12. Culturally relevant inquiry-based laboratory module implementations in upper-division genetics and cell biology teaching laboratories.

    Science.gov (United States)

    Siritunga, Dimuth; Montero-Rojas, María; Carrero, Katherine; Toro, Gladys; Vélez, Ana; Carrero-Martínez, Franklin A

    2011-01-01

    Today, more minority students are entering undergraduate programs than ever before, but they earn only 6% of all science or engineering PhDs awarded in the United States. Many studies suggest that hands-on research activities enhance students' interest in pursuing a research career. In this paper, we present a model for the implementation of laboratory research in the undergraduate teaching laboratory using a culturally relevant approach to engage students. Laboratory modules were implemented in upper-division genetics and cell biology courses using cassava as the central theme. Students were asked to bring cassava samples from their respective towns, which allowed them to compare their field-collected samples against known lineages from agricultural stations at the end of the implementation. Assessment of content and learning perceptions revealed that our novel approach allowed students to learn while engaged in characterizing Puerto Rican cassava. In two semesters, based on the percentage of students who answered correctly in the premodule assessment for content knowledge, there was an overall improvement of 66% and 55% at the end in the genetics course and 24% and 15% in the cell biology course. Our proposed pedagogical model enhances students' professional competitiveness by providing students with valuable research skills as they work on a problem to which they can relate.

  13. Reasoning about modular datatypes with Mendler induction

    Directory of Open Access Journals (Sweden)

    Paolo Torrini

    2015-09-01

    Full Text Available In functional programming, datatypes a la carte provide a convenient modular representation of recursive datatypes, based on their initial algebra semantics. Unfortunately it is highly challenging to implement this technique in proof assistants that are based on type theory, like Coq. The reason is that it involves type definitions, such as those of type-level fixpoint operators, that are not strictly positive. The known work-around of impredicative encodings is problematic, insofar as it impedes conventional inductive reasoning. Weak induction principles can be used instead, but they considerably complicate proofs. This paper proposes a novel and simpler technique to reason inductively about impredicative encodings, based on Mendler-style induction. This technique involves dispensing with dependent induction, ensuring that datatypes can be lifted to predicates and relying on relational formulations. A case study on proving subject reduction for structural operational semantics illustrates that the approach enables modular proofs, and that these proofs are essentially similar to conventional ones.

  14. Configuring Product Modularity and Service Modularity for Mass Customization Strategies

    DEFF Research Database (Denmark)

    Bask, Anu; Hsuan, Juliana; Rajahonka, Mervi

    , and how such configurations become the foundations for mass customization strategies. As a result we identify critical characteristics that are relevant for both product and services, and suggest a conceptual framework consisting of twelve dynamic mass customization strategies with paired product......Service modularity is an emerging field of research, and there has been a growing interest on how it can contribute to service design and operations management. In this study we develop a framework to assess configurations of the bundling of products and services through modularization strategies...... and service modularity. Case examples are used for illustration of different strategies....

  15. Evolution of a Computer-Based Testing Laboratory

    Science.gov (United States)

    Moskal, Patrick; Caldwell, Richard; Ellis, Taylor

    2009-01-01

    In 2003, faced with increasing growth in technology-based and large-enrollment courses, the College of Business Administration at the University of Central Florida opened a computer-based testing lab to facilitate administration of course examinations. Patrick Moskal, Richard Caldwell, and Taylor Ellis describe the development and evolution of the…

  16. Adaptive Modular Playware

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop; Þorsteinsson, Arnar Tumi

    2011-01-01

    In this paper, we describe the concept of adaptive modular playware, where the playware adapts to the interaction of the individual user. We hypothesize that there are individual differences in user interaction capabilities and styles, and that adaptive playware may adapt to the individual user...... test set, the results are important as a proof of existence of differences and of the need for adaptation. The fact that there are individual differences makes the results significant for the development of games and interaction. It indicates that it is necessary to adapt the game and interaction......, if we desire to make the most appropriate game and interaction for the individual. Hence, we investigate adaptation as an important issue for playware. With simple playware games, we show that the adaptation will speed the game up and down to find the appropriate level that matches the reaction speed...

  17. A laboratory based x-ray reflectivity system

    International Nuclear Information System (INIS)

    Holt, S.A.; Creagh, D.C.; Jamie, I.M.; Dowling, T.L.; Brown, A.S.

    1996-01-01

    Full text: X-ray Reflectivity (XRR) over the last decade has proved to be a versatile and powerful technique by which the thickness of thin films, surface roughness and interface roughness can be determined. The systems amenable to study range from organic monolayers (liquid or solid substrates) to layered metal or semiconductor systems. Access to XRR has been limited by the requirement for synchrotron radiation sources. The development of XRR systems for the laboratory environment was pioneered by Weiss. An X-ray Reflectometer has been constructed by the Department of Physics (Australian Defence Force Academy) and the Research School of Chemistry (Australian National University). The general principles of the design were similar to those described by Weiss. The reflectometer is currently in the early stages of commissioning, with encouraging results thus far. The diffraction pattern of Mobil Catalytic Material (MCM), consisting primarily of SiO 2 . The poster will describe the reflectometer, its operation and present a summary of the most important results obtained to date

  18. A Project-Based Laboratory for Learning Embedded System Design with Industry Support

    Science.gov (United States)

    Lee, Chyi-Shyong; Su, Juing-Huei; Lin, Kuo-En; Chang, Jia-Hao; Lin, Gu-Hong

    2010-01-01

    A project-based laboratory for learning embedded system design with support from industry is presented in this paper. The aim of this laboratory is to motivate students to learn the building blocks of embedded systems and practical control algorithms by constructing a line-following robot using the quadratic interpolation technique to predict the…

  19. A Learning-Cycle-Based Organic Chemistry Laboratory Program for Students in Dietetics.

    Science.gov (United States)

    Mueller, William J.

    1982-01-01

    The laboratory of an organic chemistry course for dietetics students is based on the learning cycle approach (exploration, invention-concept introduction, and concept application). The laboratory program is divided into four sections: lab techniques, compound types, reaction types, and reaction characteristics. (SK)

  20. The TriLab, a Novel ICT Based Triple Access Mode Laboratory Education Model

    Science.gov (United States)

    Abdulwahed, Mahmoud; Nagy, Zoltan K.

    2011-01-01

    This paper introduces a novel model of laboratory education, namely the TriLab. The model is based on recent advances in ICT and implements a three access modes to the laboratory experience (virtual, hands-on and remote) in one software package. A review of the three modes is provided with highlights of advantages and disadvantages of each mode.…

  1. Mapping Maize Genes: A Series of Research-Based Laboratory Exercises

    Science.gov (United States)

    Makarevitch, Irina; Kralich, Elizabeth

    2011-01-01

    Open-ended, inquiry-based multiweek laboratory exercises are the key elements to increasing students' understanding and retention of the major biological concepts. Including original research into undergraduate teaching laboratories has also been shown to motivate students and improve their learning. Here, we present a series of original…

  2. Merging Old and New: An Instrumentation-Based Introductory Analytical Laboratory

    Science.gov (United States)

    Jensen, Mark B.

    2015-01-01

    An instrumentation-based laboratory curriculum combining traditional unknown analyses with student-designed projects has been developed for an introductory analytical chemistry course. In the first half of the course, students develop laboratory skills and instrumental proficiency by rotating through six different instruments performing…

  3. Developing Digital Courseware for a Virtual Nano-Biotechnology Laboratory: A Design-Based Research Approach

    Science.gov (United States)

    Yueh, Hsiu-Ping; Chen, Tzy-Ling; Lin, Weijane; Sheen, Horn-Jiunn

    2014-01-01

    This paper first reviews applications of multimedia in engineering education, especially in laboratory learning. It then illustrates a model and accreditation criteria adopted for developing a specific set of nanotechnology laboratory courseware and reports the design-based research approach used in designing and developing the e-learning…

  4. Inquiry-based Laboratory Activities on Drugs Analysis for High School Chemistry Learning

    Science.gov (United States)

    Rahmawati, I.; Sholichin, H.; Arifin, M.

    2017-09-01

    Laboratory activity is an important part of chemistry learning, but cookbook instructions is still commonly used. However, the activity with that way do not improve students thinking skill, especially students creativity. This study aims to improve high school students creativity through inquiry-based laboratory on drugs analysis activity. Acid-base titration is used to be method for drugs analysis involving a color changing indicator. The following tools were used to assess the activity achievement: creative thinking test on acid base titration, creative attitude and action observation sheets, questionnaire of inquiry-based lab activities, and interviews. The results showed that the inquiry-based laboratory activity improving students creative thinking, creative attitude and creative action. The students reacted positively to this teaching strategy as demonstrated by results from questionnaire responses and interviews. This result is expected to help teachers to overcome the shortcomings in other laboratory learning.

  5. Virtual Cultural Landscape Laboratory Based on Internet GIS Technology

    Science.gov (United States)

    Bill, R.

    2012-07-01

    In recent years the transfer of old documents (books, paintings, maps etc.) from analogue to digital form has gained enormous importance. Numerous interventions are concentrated in the digitalisation of library collections, but also commercial companies like Microsoft or Google try to convert large analogue stocks such as books, paintings, etc. in digital form. Data in digital form can be much easier made accessible to a large user community, especially to the interested scientific community. The aim of the described research project is to set up a virtual research environment for interdisciplinary research focusing on the landscape of the historical Mecklenburg in the north-east of Germany. Georeferenced old maps from 1786 and 1890 covering complete Mecklenburg should be combined with current geo-information, satellite and aerial imagery to support spatio-temporal research aspects in different scales in space (regional 1:200,000 to local 1:25.000) and time (nearly 250 years in three time steps, the last 30 years also in three time slices). The Virtual Laboratory for Cultural Landscape Research (VKLandLab) is designed and developed by the Chair of Geodesy and Geoinformatics, hosted at the Computing Centre (ITMZ) and linked to the Digital Library (UB) at Rostock University. VKLandLab includes new developments such as wikis, blogs, data tagging, etc. and proven components already integrated in various data-related infrastructures such as InternetGIS, data repositories and authentication structures. The focus is to build a data-related infrastructure and a work platform that supports students as well as researchers from different disciplines in their research in space and time.

  6. VIRTUAL CULTURAL LANDSCAPE LABORATORY BASED ON INTERNET GIS TECHNOLOGY

    Directory of Open Access Journals (Sweden)

    R. Bill

    2012-07-01

    Full Text Available In recent years the transfer of old documents (books, paintings, maps etc. from analogue to digital form has gained enormous importance. Numerous interventions are concentrated in the digitalisation of library collections, but also commercial companies like Microsoft or Google try to convert large analogue stocks such as books, paintings, etc. in digital form. Data in digital form can be much easier made accessible to a large user community, especially to the interested scientific community. The aim of the described research project is to set up a virtual research environment for interdisciplinary research focusing on the landscape of the historical Mecklenburg in the north-east of Germany. Georeferenced old maps from 1786 and 1890 covering complete Mecklenburg should be combined with current geo-information, satellite and aerial imagery to support spatio-temporal research aspects in different scales in space (regional 1:200,000 to local 1:25.000 and time (nearly 250 years in three time steps, the last 30 years also in three time slices. The Virtual Laboratory for Cultural Landscape Research (VKLandLab is designed and developed by the Chair of Geodesy and Geoinformatics, hosted at the Computing Centre (ITMZ and linked to the Digital Library (UB at Rostock University. VKLandLab includes new developments such as wikis, blogs, data tagging, etc. and proven components already integrated in various data-related infrastructures such as InternetGIS, data repositories and authentication structures. The focus is to build a data-related infrastructure and a work platform that supports students as well as researchers from different disciplines in their research in space and time.

  7. Modular robotics for playful physiotherapy

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop

    2009-01-01

    We developed modular robotic tiles to be used for playful physiotherapy, which is supposed to motivate patients to engage in and perform physical rehabilitation exercises. We tested the modular robotic tiles for an extensive period of time (3 years) in daily use in a hospital rehabilitation unit e.......g. for cardiac patients. Also, the tiles were tested for performing physical rehabilitation of stroke patients in their private home. In all pilot test cases qualitative feedback indicate that the patients find the playful use of modular robotic tiles engaging and motivating for them to perform...

  8. A Network of Automatic Control Web-Based Laboratories

    Science.gov (United States)

    Vargas, Hector; Sanchez Moreno, J.; Jara, Carlos A.; Candelas, F. A.; Torres, Fernando; Dormido, Sebastian

    2011-01-01

    This article presents an innovative project in the context of remote experimentation applied to control engineering education. Specifically, the authors describe their experience regarding the analysis, design, development, and exploitation of web-based technologies within the scope of automatic control. This work is part of an inter-university…

  9. Marketing skills for hospital-based laboratory managers in a managed care environment.

    Science.gov (United States)

    Marchwinski, J; Coggins, F

    1997-01-01

    Managers of hospital-based laboratories have begun to realize the importance of a successful outreach program in protecting against declining inpatient activity. Succeeding in the highly competitive field of outpatient testing requires some new skills and techniques that may not have been apparent when addressing normal inpatient requirements. This article provides an overview of some very basic marketing concepts and attempts to show how they can assist the hospital-based laboratory manager in developing a successful outreach program.

  10. Hydrogen Process Coupling to Modular Helium Reactors

    International Nuclear Information System (INIS)

    Shenoy, Arkal; Richards, Matt; Buckingham, Robert

    2009-01-01

    respect to their hydrogen production costs vs. a projection of the future market value of hydrogen: (1) An Nth-of-a kind (NOAK) plant consisting of two 600-MW(t) MHR modules providing process heat to anSI-based hydrogen production facility and two 600-MW(t) MHR modules dedicated to electricity production to provide the electric power needed by the hydrogen production facility and to provide surplus electricity to the grid and (2) An NOAK HTE-based plant consisting of four 600-MW(t) MHR modules providing both process heat and electricity to the HTE-based hydrogen production facility, which consists of 292modular hydrogen production units with solid oxide electrolyzer (SOE) cells.The commercial assessment for each of the 8 plant variations involved development of a capital cost estimate and operating cost estimate (including operations and maintenance, fuel, and decommissioning costs) for the plant and an estimate of the amount of hydrogen produced by the plant in order to calculate the unit cost of hydrogen production. This unit cost was then compared against the projected market value of hydrogen that was estimated as part of an NGNP end-products study. The overall hydrogen production cost for the SI-based plant and the HTE-based plant were estimated to be about $2.26/kg and $2.22/kg, respectively. For both plants the hydrogen production cost is about 10% below the projected market value of hydrogen. GA has also been developing MHR concepts to support nearer-term industrial process-heat applications, including a concept that utilizes a steam generator to produce process steam at 540C. At present, the NHI is supporting laboratory-scale research and development of the hybrid sulfur thermochemical cycle at Savannah River National Laboratory, HTE at INL, and the SI thermochemical cycle at GA. The work being performed at GA involves collaboration among GA, Sandia National Laboratory (SNL), and the French Commissariat L' Energie Atomique (CEA) for laboratory

  11. Implementing an integrated standards-based management system to ensure compliance at Los Alamos National Laboratory

    International Nuclear Information System (INIS)

    Hjeresen, D.; Roybal, S.; Bertino, P.; Gherman, C.; Hosteny, B.

    1995-01-01

    Los Alamos National Laboratory (LANL or the Laboratory) is developing and implementing a comprehensive, Integrated Standards-Based Management System (ISBMS) to enhance environmental, safety, and health (ESH) compliance efforts and streamline management of ESH throughout the Laboratory. The Laboratory recognizes that to be competitive in today's business environment and attractive to potential Partnerships, Laboratory operations must be efficient and cost-effective. The Laboratory also realizes potential growth opportunities for developing ESH as a strength in providing new or improved services to its customers. Overall, the Laboratory desires to establish and build upon an ESH management system which ensures continuous improvement in protecting public health and safety and the environment and which fosters a working relationship with stakeholders. A team of process experts from the LANL Environmental Management (EM) Program Office, worked with management system consultants, and the Department of Energy (DOE) to develop an ESH management systems process to compare current LANL ESH management Systems and programs against leading industry standards. The process enabled the Laboratory to gauge its performance in each of the following areas: Planning and Policy Setting; Systems and Procedures; Implementation and Education; and Monitoring and Reporting. The information gathered on ESH management systems enabled LANL to pinpoint and prioritize opportunities for improvement in the provision of ESH services throughout the Laboratory and ultimately overall ESH compliance

  12. AES Modular Power Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The goals of this project are to 1) develop modular power design concepts for human exploration flight vehicles (longer-term) and assess, develop, and/or...

  13. Modular Joints for Soft Robots

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to design, optimize, and build several modular soft robotic joints which have between 3 and 6 degrees of freedom (DOF). These designs will be lighter,...

  14. Modular Inverse Algorithms Without Multiplications for Cryptographic Applications

    Directory of Open Access Journals (Sweden)

    2006-01-01

    Full Text Available Hardware and algorithmic optimization techniques are presented to the left-shift, right-shift, and the traditional Euclidean-modular inverse algorithms. Theoretical arguments and extensive simulations determined the resulting expected running time. On many computational platforms these turn out to be the fastest known algorithms for moderate operand lengths. They are based on variants of Euclidean-type extended GCD algorithms. On the considered computational platforms for operand lengths used in cryptography, the fastest presented modular inverse algorithms need about twice the time of modular multiplications, or even less. Consequently, in elliptic curve cryptography delaying modular divisions is slower (affine coordinates are the best and the RSA and ElGamal cryptosystems can be accelerated.

  15. Complex modular structure of large-scale brain networks

    Science.gov (United States)

    Valencia, M.; Pastor, M. A.; Fernández-Seara, M. A.; Artieda, J.; Martinerie, J.; Chavez, M.

    2009-06-01

    Modular structure is ubiquitous among real-world networks from related proteins to social groups. Here we analyze the modular organization of brain networks at a large scale (voxel level) extracted from functional magnetic resonance imaging signals. By using a random-walk-based method, we unveil the modularity of brain webs and show modules with a spatial distribution that matches anatomical structures with functional significance. The functional role of each node in the network is studied by analyzing its patterns of inter- and intramodular connections. Results suggest that the modular architecture constitutes the structural basis for the coexistence of functional integration of distant and specialized brain areas during normal brain activities at rest.

  16. Standard Modular Hydropower Technology Acceleration Workshop: Summary Report

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Brennan T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); DeNeale, Scott T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Witt, Adam M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Mobley, Miles H. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Fernandez, Alisha R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-08-01

    In support of the Department of Energy (DOE) funded Standard Modular Hydropower (SMH) Technology Acceleration project, Oak Ridge National Laboratory (ORNL) staff convened with five small hydropower technology entrepreneurs on June 14 and 15, 2017 to discuss gaps, challenges, and opportunities for small modular hydropower development. The workshop was designed to walk through SMH concepts, discuss the SMH research vision, assess how each participant’s technology aligns with SMH concepts and research, and identify future pathways for mutually beneficial collaboration that leverages ORNL expertise and entrepreneurial industry experience. The goal coming out of the workshop is to advance standardized, scalable, modular hydropower technologies and development approaches with sustained and open dialogue among diverse stakeholder groups.

  17. Integrating modular mechatronic systems for immersive performances

    DEFF Research Database (Denmark)

    Pagliarini, Luigi; Lund, Henrik Hautop

    2015-01-01

    and video output in a very easy manner, thanks to mechatronical wearable interfaces. In this light, we describe two of our systems that explore the concept of run-time composition of a variety of input and output modalities, e.g. both music and graphical expression. Indeed, we developed both hardware......As a branch of mechatronic research in interactivity, and in robot art, we describe the concept of implementing Playware based tools inspired by modern AI robotic systems for audio-video performances. We develop immersive and personalizable tools that can allow any user to manipulate both audio...... to create a run-time audio-video performance that is original and unique. This can further be combined with modular wearable – inspired by modular robotics – to interact and control the performance. This mechatronic wearable concept and its implementations exemplify how to convey a user-centered experience...

  18. PLM system support for modular product development

    DEFF Research Database (Denmark)

    Bruun, Hans Peter Lomholt; Mortensen, Niels Henrik; Harlou, Ulf

    2015-01-01

    is the description of an empirical tested approach using a visual product architecture representation in combination with a PLM system to support the development of a product family of products. The results from the study encompass new PLM capabilities for handling multiple product structures, visualising multiple......A modular design strategy both enables, but also demands, parallelism in design activities and collaboration between a diversity of disciplines in companies, which often involves supporting computer-based tools for enhancing interaction, design management, and communication. Product data management...... (PDM) and product lifecycle management (PLM) systems offer support by automating and managing some of the operational complexity of modular design activities. PLM system tools are used for handling a variety of product definitions, to manage workflow of development activities, and to measure relational...

  19. Implementing a modular system of computer codes

    International Nuclear Information System (INIS)

    Vondy, D.R.; Fowler, T.B.

    1983-07-01

    A modular computation system has been developed for nuclear reactor core analysis. The codes can be applied repeatedly in blocks without extensive user input data, as needed for reactor history calculations. The primary control options over the calculational paths and task assignments within the codes are blocked separately from other instructions, admitting ready access by user input instruction or directions from automated procedures and promoting flexible and diverse applications at minimum application cost. Data interfacing is done under formal specifications with data files manipulated by an informed manager. This report emphasizes the system aspects and the development of useful capability, hopefully informative and useful to anyone developing a modular code system of much sophistication. Overall, this report in a general way summarizes the many factors and difficulties that are faced in making reactor core calculations, based on the experience of the authors. It provides the background on which work on HTGR reactor physics is being carried out

  20. On subjective quality assessment of adaptive video streaming via crowdsourcing and laboratory based experiments

    DEFF Research Database (Denmark)

    Søgaard, Jacob; Shahid, Muhammad; Pokhrel, Jeevan

    2017-01-01

    is therefore instrumental in improving this understanding. Controlled laboratory based perceptual quality experiments that involve a panel of human viewers are considered to be the most valid method of the assessment of QoE. Besides laboratory based subjective experiments, crowdsourcing based subjective...... assessment of video quality is gaining popularity as an alternative method. This article presents insights into a study that investigates perceptual preferences of various adaptive video streaming scenarios through crowdsourcing based and laboratory based subjective assessment. The major novel contribution...... of this study is the application of Paired Comparison based subjective assessment in a crowdsourcing environment. The obtained results provide some novel indications, besides confirming the earlier published trends, of perceptual preferences for adaptive scenarios of video streaming. Our study suggests...

  1. The Modular Adaptive Ribosome.

    Directory of Open Access Journals (Sweden)

    Anupama Yadav

    Full Text Available The ribosome is an ancient machine, performing the same function across organisms. Although functionally unitary, recent experiments suggest specialized roles for some ribosomal proteins. Our central thesis is that ribosomal proteins function in a modular fashion to decode genetic information in a context dependent manner. We show through large data analyses that although many ribosomal proteins are essential with consistent effect on growth in different conditions in yeast and similar expression across cell and tissue types in mice and humans, some ribosomal proteins are used in an environment specific manner. The latter set of variable ribosomal proteins further function in a coordinated manner forming modules, which are adapted to different environmental cues in different organisms. We show that these environment specific modules of ribosomal proteins in yeast have differential genetic interactions with other pathways and their 5'UTRs show differential signatures of selection in yeast strains, presumably to facilitate adaptation. Similarly, we show that in higher metazoans such as mice and humans, different modules of ribosomal proteins are expressed in different cell types and tissues. A clear example is nervous tissue that uses a ribosomal protein module distinct from the rest of the tissues in both mice and humans. Our results suggest a novel stratification of ribosomal proteins that could have played a role in adaptation, presumably to optimize translation for adaptation to diverse ecological niches and tissue microenvironments.

  2. Modular isotopic thermoelectric generator

    International Nuclear Information System (INIS)

    Schock, A.

    1981-01-01

    A short history of the 10 Radioisotope Thermoelectric Generators (RTG) thus far flown in space, and design and fabrication of a new generation RTG for coupling with the General Purpose Heat Source is presented. The new RTG is modular and can be expanded in 24 W steps to whatever power levels are desired, requiring only modification of the cooling fin dimensions. Each module contains four Pu-238O 2 fuel pellets and eight elements, and failure of any module requires only replacement of that unit, without disturbing the others. 5% GaP added to the SiGe thermoelectric material has lowered thermal conductivity and raised efficiency from 0.083 to 0.105 hot junctions are at 1000 C, cold at 300 C. Details of the module design and fabrication, the hot shoe, housing, fins, all components and assembly procedures are presented. The modules are designed for initial use on the Solar Polar mission and the Galileo probe, and it is noted that the iridium cladding around the heat source pellets will withstand a planetary crash without breaching. Each module weighs 59.87 lb, has a power density of 4.71 W/lb, and is designed for a seven year mission life

  3. Exercise in Inquiry: Critical Thinking in an Inquiry-Based Exercise Physiology Laboratory Course.

    Science.gov (United States)

    DiPasquale, Dana M.; Mason, Cheryl L.; Kolkhorst, Fred W.

    2003-01-01

    Describes an inquiry-based teaching method implemented in an undergraduate exercise physiology laboratory course. Indicates students' strong, positive feelings about the inquiry-based teaching method and shows that inquiry-based learning results in a higher order of learning not typically observed in traditional style classes. This teaching method…

  4. The TOTEM modular trigger system

    Energy Technology Data Exchange (ETDEWEB)

    Bagliesi, M.G., E-mail: mg.bagliesi@pi.infn.i [University of Siena and INFN Pisa (Italy); Berretti, M.; Cecchi, R.; Greco, V.; Lami, S.; Latino, G.; Oliveri, E.; Pedreschi, E.; Scribano, A.; Spinella, F.; Turini, N. [University of Siena and INFN Pisa (Italy)

    2010-05-21

    The TOTEM experiment will measure the total cross-section with the luminosity independent method and study elastic and diffractive scattering at the LHC. We are developing a modular trigger system, based on programmable logic, that will select meaningful events within 2.5{mu}s. The trigger algorithm is based on a tree structure in order to obtain information compression. The trigger primitive is generated directly on the readout chip, VFAT, that has a specific fast output that gives low resolution hits information. In two of the TOTEM detectors, Roman Pots and T2, a coincidence chip will perform track recognition directly on the detector readout boards, while for T1 the hits are transferred from the VFATs to the trigger hardware. Starting from more than 2000 bits delivered by the detector electronics, we extract, in a first step, six trigger patterns of 32 LVDS signals each; we build, then, on a dedicated board, a 1-bit (L1) trigger signal for the TOTEM experiment and 16 trigger bits to the CMS experiment global trigger system for future common data taking.

  5. The TOTEM modular trigger system

    International Nuclear Information System (INIS)

    Bagliesi, M.G.; Berretti, M.; Cecchi, R.; Greco, V.; Lami, S.; Latino, G.; Oliveri, E.; Pedreschi, E.; Scribano, A.; Spinella, F.; Turini, N.

    2010-01-01

    The TOTEM experiment will measure the total cross-section with the luminosity independent method and study elastic and diffractive scattering at the LHC. We are developing a modular trigger system, based on programmable logic, that will select meaningful events within 2.5μs. The trigger algorithm is based on a tree structure in order to obtain information compression. The trigger primitive is generated directly on the readout chip, VFAT, that has a specific fast output that gives low resolution hits information. In two of the TOTEM detectors, Roman Pots and T2, a coincidence chip will perform track recognition directly on the detector readout boards, while for T1 the hits are transferred from the VFATs to the trigger hardware. Starting from more than 2000 bits delivered by the detector electronics, we extract, in a first step, six trigger patterns of 32 LVDS signals each; we build, then, on a dedicated board, a 1-bit (L1) trigger signal for the TOTEM experiment and 16 trigger bits to the CMS experiment global trigger system for future common data taking.

  6. DOE weapons laboratories' contributions to the nation's defense technology base

    Energy Technology Data Exchange (ETDEWEB)

    Hecker, S.S.

    1988-04-01

    The question of how the Department of Energy (DOE) weapons laboratories can contribute to a stronger defense technology base is addressed in testimony before the Subcommittee on Defense Industry and Technology of the Senate Armed Services Committee. The importance of the defense technology base is described, the DOE technology base is also described, and some technology base management and institutional issues are discussed. Suggestions are given for promoting a more stable, long-term relationship between the DOE weapons laboratories and the Department of Defense. 12 refs., 2 figs.

  7. Advanced Small Modular Reactor Economics Model Development

    Energy Technology Data Exchange (ETDEWEB)

    Harrison, Thomas J [ORNL

    2014-10-01

    The US Department of Energy Office of Nuclear Energy’s Advanced Small Modular Reactor (SMR) research and development activities focus on four key areas: Developing assessment methods for evaluating advanced SMR technologies and characteristics; and Developing and testing of materials, fuels and fabrication techniques; and Resolving key regulatory issues identified by US Nuclear Regulatory Commission and industry; and Developing advanced instrumentation and controls and human-machine interfaces. This report focuses on development of assessment methods to evaluate advanced SMR technologies and characteristics. Specifically, this report describes the expansion and application of the economic modeling effort at Oak Ridge National Laboratory. Analysis of the current modeling methods shows that one of the primary concerns for the modeling effort is the handling of uncertainty in cost estimates. Monte Carlo–based methods are commonly used to handle uncertainty, especially when implemented by a stand-alone script within a program such as Python or MATLAB. However, a script-based model requires each potential user to have access to a compiler and an executable capable of handling the script. Making the model accessible to multiple independent analysts is best accomplished by implementing the model in a common computing tool such as Microsoft Excel. Excel is readily available and accessible to most system analysts, but it is not designed for straightforward implementation of a Monte Carlo–based method. Using a Monte Carlo algorithm requires in-spreadsheet scripting and statistical analyses or the use of add-ons such as Crystal Ball. An alternative method uses propagation of error calculations in the existing Excel-based system to estimate system cost uncertainty. This method has the advantage of using Microsoft Excel as is, but it requires the use of simplifying assumptions. These assumptions do not necessarily bring into question the analytical results. In fact, the

  8. Activity-based costing methodology as tool for costing in hematopathology laboratory

    Directory of Open Access Journals (Sweden)

    Gujral Sumeet

    2010-01-01

    Full Text Available Background: Cost analysis in laboratories represents a necessary phase in their scientific progression. Aim: To calculate indirect cost and thus total cost per sample of various tests at Hematopathology laboratory (HPL Settings and Design: Activity-based costing (ABC method is used to calculate per cost test of the hematopathology laboratory. Material and Methods: Information is collected from registers, purchase orders, annual maintenance contracts (AMCs, payrolls, account books, hospital bills and registers along with informal interviews with hospital staff. Results: Cost per test decreases as total number of samples increases. Maximum annual expense at the HPL is on reagents and consumables followed by manpower. Cost per test is higher for specialized tests which interpret morphological or flow data and are done by a pathologist. Conclusions: Despite several limitations and assumptions, this was an attempt to understand how the resources are consumed in a large size government-run laboratory. The rate structure needs to be revised for most of the tests, mainly for complete blood counts (CBC, bone marrow examination, coagulation tests and Immunophenotyping. This costing exercise is laboratory specific and each laboratory needs to do its own costing. Such an exercise may help a laboratory redesign its costing structure or at least understand the economics involved in the laboratory management.

  9. Activity-based costing methodology as tool for costing in hematopathology laboratory.

    Science.gov (United States)

    Gujral, Sumeet; Dongre, Kanchan; Bhindare, Sonal; Subramanian, P G; Narayan, Hkv; Mahajan, Asim; Batura, Rekha; Hingnekar, Chitra; Chabbria, Meenu; Nair, C N

    2010-01-01

    Cost analysis in laboratories represents a necessary phase in their scientific progression. To calculate indirect cost and thus total cost per sample of various tests at Hematopathology laboratory (HPL). Activity-based costing (ABC) method is used to calculate per cost test of the hematopathology laboratory. Information is collected from registers, purchase orders, annual maintenance contracts (AMCs), payrolls, account books, hospital bills and registers along with informal interviews with hospital staff. Cost per test decreases as total number of samples increases. Maximum annual expense at the HPL is on reagents and consumables followed by manpower. Cost per test is higher for specialized tests which interpret morphological or flow data and are done by a pathologist. Despite several limitations and assumptions, this was an attempt to understand how the resources are consumed in a large size government-run laboratory. The rate structure needs to be revised for most of the tests, mainly for complete blood counts (CBC), bone marrow examination, coagulation tests and Immunophenotyping. This costing exercise is laboratory specific and each laboratory needs to do its own costing. Such an exercise may help a laboratory redesign its costing structure or at least understand the economics involved in the laboratory management.

  10. Convergent evolution of modularity in metabolic networks through different community structures

    Directory of Open Access Journals (Sweden)

    Zhou Wanding

    2012-09-01

    Full Text Available Abstract Background It has been reported that the modularity of metabolic networks of bacteria is closely related to the variability of their living habitats. However, given the dependency of the modularity score on the community structure, it remains unknown whether organisms achieve certain modularity via similar or different community structures. Results In this work, we studied the relationship between similarities in modularity scores and similarities in community structures of the metabolic networks of 1021 species. Both similarities are then compared against the genetic distances. We revisited the association between modularity and variability of the microbial living environments and extended the analysis to other aspects of their life style such as temperature and oxygen requirements. We also tested both topological and biological intuition of the community structures identified and investigated the extent of their conservation with respect to the taxomony. Conclusions We find that similar modularities are realized by different community structures. We find that such convergent evolution of modularity is closely associated with the number of (distinct enzymes in the organism’s metabolome, a consequence of different life styles of the species. We find that the order of modularity is the same as the order of the number of the enzymes under the classification based on the temperature preference but not on the oxygen requirement. Besides, inspection of modularity-based communities reveals that these communities are graph-theoretically meaningful yet not reflective of specific biological functions. From an evolutionary perspective, we find that the community structures are conserved only at the level of kingdoms. Our results call for more investigation into the interplay between evolution and modularity: how evolution shapes modularity, and how modularity affects evolution (mainly in terms of fitness and evolvability. Further, our results

  11. Lectures on Hilbert modular varieties and modular forms

    CERN Document Server

    Goren, Eyal Z

    2001-01-01

    This book is devoted to certain aspects of the theory of p-adic Hilbert modular forms and moduli spaces of abelian varieties with real multiplication. The theory of p-adic modular forms is presented first in the elliptic case, introducing the reader to key ideas of N. M. Katz and J.-P. Serre. It is re-interpreted from a geometric point of view, which is developed to present the rudiments of a similar theory for Hilbert modular forms. The theory of moduli spaces of abelian varieties with real multiplication is presented first very explicitly over the complex numbers. Aspects of the general theory are then exposed, in particular, local deformation theory of abelian varieties in positive characteristic. The arithmetic of p-adic Hilbert modular forms and the geometry of moduli spaces of abelian varieties are related. This relation is used to study q-expansions of Hilbert modular forms, on the one hand, and stratifications of moduli spaces on the other hand. The book is addressed to graduate students and non-exper...

  12. Digital lock-in amplifier based on soundcard interface for physics laboratory

    Science.gov (United States)

    Sinlapanuntakul, J.; Kijamnajsuk, P.; Jetjamnong, C.; Chotikaprakhan, S.

    2017-09-01

    The purpose of this paper is to develop a digital lock-in amplifier based on soundcard interface for undergraduate physics laboratory. Both series and parallel RLC circuit laboratory are tested because of its well-known, easy to understand and simple confirm. The sinusoidal signal at the frequency of 10 Hz - 15 kHz is generated to the circuits. The amplitude and phase of the voltage drop across the resistor, R are measured in 10 step decade. The signals from soundcard interface and lock-in amplifier are compared. The results give a good correlation. It indicates that the design digital lock-in amplifier is promising for undergraduate physic laboratory.

  13. Community-driven standards-based electronic laboratory data-sharing networks.

    Science.gov (United States)

    Zarcone, Patina; Nordenberg, Dale; Meigs, Michelle; Merrick, Ulrike; Jernigan, Daniel; Hinrichs, Steven H

    2010-01-01

    Public health laboratories (PHLs) are critical components of the nation's healthcare system, serving as stewards of valuable specimens, delivering important diagnostic results to support clinical and public health programs, supporting public health policy, and conducting research. This article discusses the need for and challenges of creating standards-based data-sharing networks across the PHL community, which led to the development of the PHL Interoperability Project (PHLIP). Launched by the Association of Public Health Laboratories and the Centers for Disease Control and Prevention in September 2006, PHLIP has leveraged a unique community-based collaborative process, catalyzing national capabilities to more effectively share electronic laboratory-generated diagnostic information and bolster the nation's health security. PHLIP is emerging as a model of accelerated innovation for the fields of laboratory science, technology, and public health.

  14. Comparison of semen quality between university-based and private assisted reproductive technology laboratories

    DEFF Research Database (Denmark)

    Jensen, Christian Fuglesang S; Khan, Omar; Sønksen, Jens

    2018-01-01

    .9%). No significant differences were found in volume, concentration and total motile sperm count although the Bland-Altman plot bias for concentration was clinically significant (15.9 × 106/ml). CONCLUSIONS: In this small series, motility was significantly higher at private laboratories compared to a university......OBJECTIVE: Obtaining a semen analysis (SA) is an essential step in evaluating infertile men. Despite using standardized procedures for analysis semen quality in the same individual often varies on repeated tests. The objective of this study was to investigate inter-laboratory variation in semen...... quality between private- and university-based assisted reproductive technology (ART) laboratories. MATERIALS AND METHODS: IRB approval was obtained to retrospectively evaluate men with a SA at both the private- and university-based ART laboratories. When more than one SA was available from either...

  15. Advanced Small Modular Reactor Economics Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Harrison, Thomas J [ORNL

    2014-10-01

    This report describes the data collection work performed for an advanced small modular reactor (AdvSMR) economics analysis activity at the Oak Ridge National Laboratory. The methodology development and analytical results are described in separate, stand-alone documents as listed in the references. The economics analysis effort for the AdvSMR program combines the technical and fuel cycle aspects of advanced (non-light water reactor [LWR]) reactors with the market and production aspects of SMRs. This requires the collection, analysis, and synthesis of multiple unrelated and potentially high-uncertainty data sets from a wide range of data sources. Further, the nature of both economic and nuclear technology analysis requires at least a minor attempt at prediction and prognostication, and the far-term horizon for deployment of advanced nuclear systems introduces more uncertainty. Energy market uncertainty, especially the electricity market, is the result of the integration of commodity prices, demand fluctuation, and generation competition, as easily seen in deregulated markets. Depending on current or projected values for any of these factors, the economic attractiveness of any power plant construction project can change yearly or quarterly. For long-lead construction projects such as nuclear power plants, this uncertainty generates an implied and inherent risk for potential nuclear power plant owners and operators. The uncertainty in nuclear reactor and fuel cycle costs is in some respects better understood and quantified than the energy market uncertainty. The LWR-based fuel cycle has a long commercial history to use as its basis for cost estimation, and the current activities in LWR construction provide a reliable baseline for estimates for similar efforts. However, for advanced systems, the estimates and their associated uncertainties are based on forward-looking assumptions for performance after the system has been built and has achieved commercial operation

  16. TOOLS AND TECHNIQUES FOR IMPROVING THE MODULAR FIXTURE DESIGN IN AUTODESK INVENTOR

    Directory of Open Access Journals (Sweden)

    PĂUNESCU Rodica

    2015-06-01

    Full Text Available The paper presents some strategies achieving significant productivity gains in modular fixture design like: intelligent tools iParts, iAssembly, iProperties, Constraint and Joint, Interference, Relationships tools, working with subassemblies, using Autodesk Inventor new releases. Another objective is to minimize modular fixture systems databases and to optimize searching and inserting components. All this techniques and tools are exemplified by a modular fixture based on grid patterns with multipurpose holes.

  17. Investigating the Impact on Student Learning and Outdoor Science Interest through Modular Serious Educational Games: A Design-Based Research Study

    Science.gov (United States)

    Folta, Elizabeth Eason

    In an effort to get children back outdoors and exploring the natural environment, a Modular Serious Educational Game (mSEG), Red Wolf Caper, was created as part of a design-based research study. Red Wolf Caper uses a combination of an augmented reality (AR) game and a serious educational game (SEG) to capture the students' interest in the natural world around them. The game is set around a mystery in which red wolves in eastern North Carolina are being poisoned. The students are asked to portray the role of a wildlife biologist, botanist, or entomologist, whose job it is to determine who is poisoning the red wolves. MSEG are a new form of SEG that is divided into components or modules. Each module has to be completed before the player can move on to the next module. A module can take on any format, but must encompass the storyline of the game and end in an assessment. The study focused on three research questions. How would students improve the Red Wolf Caper mSEG? Do mSEG affect students' understanding in environmental education concepts, specifically, collecting, evaluating, and developing an explanation for data they collected in the game and knowledge of environmental systems and biological and social implications for the reintroduction of a species? Which role within the mSEG do the students choose and what is their reasoning behind choosing that particular role? The game was tested by 81 middle school students during six sessions in June 2010. The study participants played the game and participated in design sessions. In addition, they were given a 5-question pretest/ posttest, role selection survey, and Serious Educational Game Rubric (SEGR). They were asked to develop a hypothesis and provide evidence to support their hypothesis. Finally, they were asked to write a letter to a local in judge explaining the importance of the red wolf reintroduction project. Twenty-three students were selected to participate in interviews to determine how to improve the game

  18. DEVELOPMENT OF CONCEPT OF HARDWARE-SOFTWARE COMPLEX OF MODULAR DESIGN FOR DETERMINATION OF ANTENNA SYSTEMS׳ CHARACTERISTICS BASED ON MEASUREMENTS IN THE NEAR FIELD

    Directory of Open Access Journals (Sweden)

    A. G. Buday

    2017-01-01

    Full Text Available Measuring the amplitude-phase distribution of the radiation field of complex antenna systems on a certain surface close to the radiating aperture allows solving the problem of reconstructing the free-space diagram in the far field and also helps in determining the influence of various structural elements and defects of radiating surfaces on formation of directional diagram. The purpose of this work was to develop a universal hardware-software complex of a modular design aimed for determining the characteristics of wide range of antenna systems in respect of measurements of the amplitude-phase distribution of the radiation field in the near zone.The equations that connect the structure of radiation fields of the antenna system at various distances from it in planar, cylindrical and spherical coordinate systems as well as structural diagrams of the hardware part of measuring complexes have been analyzed.As a result, the concept of constructing a universal hardware-software complex for measuring the radiation field of various types of antenna systems with any type of measurement surface for solving a wide range of applied problems has been developed. A modular structure of hardware and software has been proposed; it allows reconfiguring the complex rapidly in order to measure the characteristics of any particular antenna system at all stages of product development and testing, and also makes the complex economically accessible even for small enterprises and organizations.

  19. A multivariate assessment of the effect of the laboratory homework component of a microcomputer-based laboratory for a college freshman physics course

    Science.gov (United States)

    Ramlo, Susan E.

    Microcomputer-based laboratories (MBLs) have been defined as software that uses an electronic probe to collect information about a physical system and then converts that information into graphical systems in real-time. Realtime Physics Laboratories (RTP) are an example of laboratories that combine the use of MBLs with collaboration and guided-inquiry. RTP Mechanics Laboratories include both laboratory activities and laboratory homework for the first semester of college freshman physics courses. Prior research has investigated the effectiveness of the RTP laboratories as a package (laboratory activities with laboratory homework). In this study, an experimental-treatment had students complete both the RTP laboratory activity and the associated laboratory homework during the same laboratory period. Observations of this treatment indicated that students primarily consulted the laboratory instructor and referred to their completed laboratory activity while completing the homework in their collaborative groups. In the control-treatment, students completed the laboratory homework outside the laboratory period. Measures of force and motion conceptual understanding included the Force and Motion Conceptual Understanding (FMCE), a 47 multiple-choice question test. Analyses of the FMCE indicated that it is both a reliable and a valid measure of force and motion conceptual understanding. A distinct, five-factor structure for the FMCE post-test answers reflected specific concepts related to force and motion. However, the three FMCE pretest factors were less distinct. Analysis of the experimental-treatment, compared to a control-treatment, included multiple regression analysis with covariates of age, prior physics-classroom experience, and the three FMCE pretest factors. Criterion variables included each of the five post-test factors, the total laboratory homework score, and a group of seven exam questions. The results were all positive, in favor of the experimental

  20. Development and Assessment of Green, Research-Based Instructional Materials for the General Chemistry Laboratory

    Science.gov (United States)

    Cacciatore, Kristen L.

    2010-01-01

    This research entails integrating two novel approaches for enriching student learning in chemistry into the context of the general chemistry laboratory. The first is a pedagogical approach based on research in cognitive science and the second is the green chemistry philosophy. Research has shown that inquiry-based approaches are effective in…

  1. A Scoping Study Investigating Student Perceptions towards Inquiry Based Learning in the Laboratory

    Science.gov (United States)

    King, Nicola; Van der Touw, Thomas; Spowart, Lucy; Lawlor, Craig

    2016-01-01

    There has been an increasing movement towards the introduction of inquiry based learning in undergraduate physiology laboratories. Students can however find this challenging when there is a sudden transition from traditional didactic practicals to full inquiry based activities. One reason for this could be the students' perceptions about the…

  2. Successful Implementation of Inquiry-Based Physiology Laboratories in Undergraduate Major and Nonmajor Courses

    Science.gov (United States)

    Casotti, G.; Rieser-Danner, L.; Knabb, M. T.

    2008-01-01

    Recent evidence has demonstrated that inquiry-based physiology laboratories improve students' critical- and analytical-thinking skills. We implemented inquiry-based learning into three physiology courses: Comparative Vertebrate Physiology (majors), Human Physiology (majors), and Human Anatomy and Physiology (nonmajors). The aims of our curricular…

  3. THE ROLE OF LABORATORY-BASED PRACTICAL EXERCISES IN THE THEORETICAL CONCEPTS LEARNING

    Directory of Open Access Journals (Sweden)

    B. C. Rossi

    2007-05-01

    Full Text Available Besides to equip the students to perform, analyze and interpret laboratoryinvestigations and to demonstrate familiarity with handling and using laboratoryinstrumentation, the laboratory-based practical exercises expect to integratetheoretical concepts and practical skills. This work is a preliminary study toinvestigate the relationship between the concepts learned in the lectures and theconcepts applied in the lab classes. Firstly we compared the students gradesobtained in the exams with their grades in the laboratory exercises reports. Itshows a non-significance correlation (Spearman between the exams and reportsgrades. In a second moment we compared the students grades obtained in a preselectedexam question with the grades obtained in the related laboratory exercisereport. In this case, we could observe a significant correlation between the examsand the reports grades. This preliminary study held with 82 biology studentssuggests that the top scored students in the exams are not necessary the sametop scored students in the laboratory exercises reports, but the students who havethe higher scores in the laboratory exercises reports have also the higher scores inthe questions related to the laboratory exercise asked in the exam. These resultssuggest that the laboratory classes have an important role in the theoreticalconcepts learning.

  4. Water quality laboratories in Colombia: a GIS-based study of urban and rural accessibility.

    Science.gov (United States)

    Wright, Jim; Liu, Jing; Bain, Robert; Perez, Andrea; Crocker, Jonny; Bartram, Jamie; Gundry, Stephen

    2014-07-01

    The objective of this study was to quantify sample transportation times associated with mandated microbiological monitoring of drinking-water in Colombia. World Health Organization Guidelines for Drinking-Water Quality recommend that samples spend no more than 6h between collection and analysis in a laboratory. Census data were used to estimate the minimum number of operational and surveillance samples required from piped water supplies under national regulations. Drive-times were then computed from each supply system to the nearest accredited laboratory and translated into sample holding times based on likely daily monitoring patterns. Of 62,502 surveillance samples required annually, 5694 (9.1%) were found to be more than 6 h from the nearest of 278 accredited laboratories. 612 samples (1.0%) were more than 24 hours' drive from the nearest accredited laboratory, the maximum sample holding time recommended by the World Health Organization. An estimated 30% of required rural samples would have to be stored for more than 6 h before reaching a laboratory. The analysis demonstrates the difficulty of undertaking microbiological monitoring in rural areas and small towns from a fixed laboratory network. Our GIS-based approach could be adapted to optimise monitoring strategies and support planning of testing and transportation infra-structure development. It could also be used to estimate sample transport and holding times in other countries. Copyright © 2014 Elsevier B.V. All rights reserved.

  5. Development of Virtual Laboratory Based on Interactive Multimedia on Planting and Painting Bacteria

    Science.gov (United States)

    Yuniarti, A.; Yeni, L. F.; Yokhebed

    2017-09-01

    The Aim of this research is to produce Virtual Laboratory based on interactive multimedia on sub material of planting and painting bacteria. Knowing eligibility of the media and knowing the student’s respond that has been taught of using Virtual Laboratory. The method of this research is development research. This research consists of two stages are preliminary (preparation and design) and formative evaluation (self evaluation, expert reviews, small group and fields test). Data collection techniques used in this research are questionnaires and tests. The subject of this research is 37 students. Based on validation result from validator expert, Virtual Laboratory is categorized valid. This value is obtained because Virtual Laboratory can be installed in various hardware and software, easy to use, the program works well, and Virtual lab has a unique shape, interactive and good animation. Meanwhile, students give the positive respond, it means student can operate and simulate the experiment of planting and painting bacteria with Virtual Laboratory and helps students to understand the material of planting and painting bacteria easily. So it can be concluded that Virtual Laboratory has legibility to be used as learning media.

  6. Modularity in Cancer Care Provision

    DEFF Research Database (Denmark)

    Gobbi, Chiara; Hsuan, Juliana

    2012-01-01

    The paper presents the findings of a case study research conducted within the Danish healthcare system aimed at analyzing how modularity is deployed in the process of delivery cancer care. Three cancer packages are presented into detailed describing the process of defining the diagnosis and treat......The paper presents the findings of a case study research conducted within the Danish healthcare system aimed at analyzing how modularity is deployed in the process of delivery cancer care. Three cancer packages are presented into detailed describing the process of defining the diagnosis...... and treatment service. Customization is obtained by combining different components in the diagnosis phase (examinations) and different treatment options in the treating phase. Findings show that the process of delivery cure for cancer is highly modularized and customization is driven by cancer specificity (type...

  7. Modular Software-Defined Radio

    Directory of Open Access Journals (Sweden)

    Rhiemeier Arnd-Ragnar

    2005-01-01

    Full Text Available In view of the technical and commercial boundary conditions for software-defined radio (SDR, it is suggestive to reconsider the concept anew from an unconventional point of view. The organizational principles of signal processing (rather than the signal processing algorithms themselves are the main focus of this work on modular software-defined radio. Modularity and flexibility are just two key characteristics of the SDR environment which extend smoothly into the modeling of hardware and software. In particular, the proposed model of signal processing software includes irregular, connected, directed, acyclic graphs with random node weights and random edges. Several approaches for mapping such software to a given hardware are discussed. Taking into account previous findings as well as new results from system simulations presented here, the paper finally concludes with the utility of pipelining as a general design guideline for modular software-defined radio.

  8. Increasing Efficiency and Quality by Consolidation of Clinical Chemistry and Immunochemistry Systems with MODULAR ANALYTICS SWA.

    Science.gov (United States)

    Mocarelli, Paolo; Horowitz, Gary L; Gerthoux, Pier Mario; Cecere, Rossana; Imdahl, Roland; Ruinemans-Koerts, Janneke; Luthe, Hilmar; Calatayud, Silvia Pesudo; Salve, Marie Luisa; Kunst, Albert; McGovern, Margaret; Ng, Katherine; Stockmann, Wolfgang

    2008-01-01

    MODULAR ANALYTICS Serum Work Area (in USA Integrated MODULAR ANALYTICS, MODULAR ANALYTICS is a trademark of a member of the Roche Group) represents a further approach to automation in the laboratory medicine. This instrument combines previously introduced modular systems for the clinical chemistry and immunochemistry laboratory and allows customised combinations for various laboratory workloads. Functionality, practicability, and workflow behaviour of MODULAR ANALYTICS Serum Work Area were evaluated in an international multicenter study at six laboratories. Across all experiments, 236000 results from 32400 samples were generated using 93 methods. Simulated routine testing which included provocation incidents and anomalous situations demonstrated good performance and full functionality. Heterogeneous immunoassays, performed on the E-module with the electrochemiluminescence technology, showed reproducibility at the same level of the general chemistry tests, which was well within the clinical demands. Sample carryover cannot occur due to intelligent sample processing. Workflow experiments for the various module combinations, with menus of about 50 assays, yielded mean sample processing times of chemistry and immunochemistry requests; ANALYTICS Serum Work Area offered simplified workflow by combining various laboratory segments. It increased efficiency while maintaining or even improving quality of laboratory processes.

  9. Modular Robotic System as Multisensory Room in Children’s Hospital

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop; Henningsen, Anders; Nielsen, Rasmus

    2009-01-01

    We developed a system composed of different modular robotic devices, which can be used e.g. as a multi-sensory room in hospital settings. The system composed of the modular robotic devices engage the user in physical activities, and should motivate to perform physical activities by providing...... immediate feedback based upon physical interaction with the system. The modularity, ease of use and the functionality of the devices such as modular robotic tiles and cubic I-BLOCKS suit well into these kinds of scenarios, because they can provide feedback in terms of light, vibration, sound and possibly...

  10. The Role of Computer-Based Educational Laboratories in Nuclear Engineering University Programmes

    International Nuclear Information System (INIS)

    Korolev, S.A.; Kosilov, A.N.; Chernov, E.V.; Vygovskiy, S.B.

    2014-01-01

    The specialized Educational and research laboratory 'Reactor physics, control and safe operation of WWER type NPP’ is based on the computer simulator of WWER -1000 and offers the real-time monitoring of data available to the WWER -1000 NPP control room operators, and provides a possibility to investigate reactor behavior in normal and abnormal situations. The laboratory supports interactive technologies and team-based activities that enable students to build their knowledge through required gateway courses and explore problems relevant to real life situations

  11. Emergent interfaces for feature modularization

    CERN Document Server

    Ribeiro, Márcio; Brabrand, Claus

    2014-01-01

    Developers frequently introduce errors into software systems when they fail to recognise module dependencies. Using forty-three software families and Software Product Lines (SPLs), where the majority are commonly used in industrial practice, the authors reports on the feature modularization problem and provides a study of how often it may occur in practice. To solve the problem they present the concept of emergent feature modularization which aims to establish contracts between features to prevent developers from breaking other features when performing a maintenance task.

  12. Modularity in Cancer Care Provision

    DEFF Research Database (Denmark)

    Gobbi, Chiara; Hsuan, Juliana

    2012-01-01

    and treatment service. Customization is obtained by combining different components in the diagnosis phase (examinations) and different treatment options in the treating phase. Findings show that the process of delivery cure for cancer is highly modularized and customization is driven by cancer specificity (type......The paper presents the findings of a case study research conducted within the Danish healthcare system aimed at analyzing how modularity is deployed in the process of delivery cancer care. Three cancer packages are presented into detailed describing the process of defining the diagnosis...

  13. Inherent controllability in modular ALMRs

    International Nuclear Information System (INIS)

    Sackett, J.I.; Sevy, R.H.; Wei, T.Y.C.

    1989-01-01

    As part of recent development efforts on advanced reactor designs ANL has proposed the IFR (Integral Fast Reactor) concept. The IFR concept is currently being applied to modular sized reactors which would be built in multiple power paks together with an integrated fuel cycle facility. It has been amply demonstrated that the concept as applied to the modular designs has significant advantages in regard to ATWS transients. Attention is now being focussed on determining whether or not those advantages deriving from the traits of the IFR can be translated to the operational/DBA (design basis accident) class of transients. 5 refs., 3 figs., 3 tabs

  14. Laboratory and project based learning in the compulsory course Biological Chemistry enhancing collaboration and technical communication between groups

    DEFF Research Database (Denmark)

    Agersø, Yvonne; Bysted, Anette; Jensen, Lars Bogø

    2011-01-01

    The aim of this paper was to describe how changes of laboratory training and project based learning were implemented in order to train the students in making a study design, basic laboratory skills, handling of data, technical communication, collaboration and presentation.......The aim of this paper was to describe how changes of laboratory training and project based learning were implemented in order to train the students in making a study design, basic laboratory skills, handling of data, technical communication, collaboration and presentation....

  15. Modular Manufacturing Simulator: Users Manual

    Science.gov (United States)

    1997-01-01

    The Modular Manufacturing Simulator (MMS) has been developed for the beginning user of computer simulations. Consequently, the MMS cannot model complex systems that require branching and convergence logic. Once a user becomes more proficient in computer simulation and wants to add more complexity, the user is encouraged to use one of the many available commercial simulation systems. The (MMS) is based on the SSE5 that was developed in the early 1990's by the University of Alabama in Huntsville (UAH). A recent survey by MSFC indicated that the simulator has been a major contributor to the economic impact of the MSFC technology transfer program. Many manufacturers have requested additional features for the SSE5. Consequently, the following features have been added to the MMS that are not available in the SSE5: runs under Windows, print option for both input parameters and output statistics, operator can be fixed at a station or assigned to a group of stations, operator movement based on time limit, part limit, or work-in-process (WIP) limit at next station. The movement options for a moveable operators are: go to station with largest WIP, rabbit chase where operator moves in circular sequence between stations, and push/pull where operator moves back and forth between stations. This user's manual contains the necessary information for installing the MMS on a PC, a description of the various MMS commands, and the solutions to a number of sample problems using the MMS. Also included in the beginning of this report is a brief discussion of technology transfer.

  16. [Development of a Web-based laboratory data browser integrated with heterogeneous clinical information].

    Science.gov (United States)

    Fujikawa, Jun

    2009-02-01

    To demonstrate the feasibility of a Web-based laboratory data browser integrated with heterogeneous clinical information in a hospital setting. A Java-based web application was developed in-house, using free open-source software. The server side manages queries to heterogeneous hospital databases containing patient data. Order entry information including laboratory test results, drug prescriptions, injection orders, physiological test orders and, imaging test orders, was retrieved from a replication database, and integrated with nursing data from a nursing system database. The result was visualized in a time-series table format, and accessed by web browsers on computers connected to the hospital intranet. The laboratory data browser system achieved practical response times over huge databases (> 90 million records). The medical personnel accepted the system well, and applied the system to various clinical situations. Integrating heterogeneous data from hospital databases in a Web-based laboratory data browser is a practical approach. Presenting relevant medical information simultaneously added value to the laboratory data, and may promote better medical management.

  17. ENVIRONMENTAL RISK ASSESSMENT OF SOME COPPER BASED FUNGICIDES ACCORDING TO THE REQUIREMENTS OF GOOD LABORATORY PRACTICE

    Directory of Open Access Journals (Sweden)

    Marga GRĂDILĂ

    2015-10-01

    Full Text Available The paper presents data demonstrating the functionality of biological systems reconstituted with aquatic organisms developed under Good Laboratory Practice testing facility within Research - Development Institute for Plant Protection Bucharest for environmental risk assessment of four fungicides based on copper, according to Good Laboratory Practice requirements. For risk assessment, according to GLP were made the following steps: Good Laboratory Practice test facility was established, we have ensured adequate space for growth, acclimatization and testing for each test species, it was installed a complex water production instalation needed to perform tests, it was achieved control system for checking environmental conditions and have developed specific operating procedures that have been accredited according to Good Laboratory Practice.The results showed that biological systems model of the Good Laboratory Practice test facility in Research - Development Institute for Plant Protection meet the requirements of Organisation for Economic Co-operation and Development Guidelines regarding GLP, and after testing copper-based fungicides in terms of acute toxicity Cyprinus carpio and to Daphnia magna revealed that three of them (copper oxychloride, copper hydroxide and copper sulphate showed ecological efficiency, ie low toxicity. Metallic copper based fungicides showed a higher toxicity, resulting in fish toxicity symptoms: sleep, sudden immersion, faded, weakness, swimming in spiral, lack of balance, breathing slow and cumbersome, spasms and mortality.

  18. Decentralizing decision making in modularization strategies

    DEFF Research Database (Denmark)

    Israelsen, Poul; Jørgensen, Brian

    2011-01-01

    Research on product modularity is dominated by an operations management (OM) perspective, through which numerous models to predict optimal modularization strategies have been developed. However, we argue that implementation of these predictions is hampered by prevailing project accounting systems...

  19. Modular envelopes, OSFT and nonsymmetric (non-$\\sum$) modular operads

    Czech Academy of Sciences Publication Activity Database

    Markl, Martin

    2016-01-01

    Roč. 10, č. 2 (2016), s. 775-809 ISSN 1661-6952 Institutional support: RVO:67985840 Keywords : open string * surface * modular completion Subject RIV: BA - General Mathematics Impact factor: 0.625, year: 2016 http://www.ems-ph.org/journals/show_abstract.php?issn=1661-6952&vol=10&iss=2&rank=12

  20. Accelerator-based techniques for the support of senior-level undergraduate physics laboratories

    Science.gov (United States)

    Williams, J. R.; Clark, J. C.; Isaacs-Smith, T.

    2001-07-01

    Approximately three years ago, Auburn University replaced its aging Dynamitron accelerator with a new 2MV tandem machine (Pelletron) manufactured by the National Electrostatics Corporation (NEC). This new machine is maintained and operated for the University by Physics Department personnel, and the accelerator supports a wide variety of materials modification/analysis studies. Computer software is available that allows the NEC Pelletron to be operated from a remote location, and an Internet link has been established between the Accelerator Laboratory and the Upper-Level Undergraduate Teaching Laboratory in the Physics Department. Additional software supplied by Canberra Industries has also been used to create a second Internet link that allows live-time data acquisition in the Teaching Laboratory. Our senior-level undergraduates and first-year graduate students perform a number of experiments related to radiation detection and measurement as well as several standard accelerator-based experiments that have been added recently. These laboratory exercises will be described, and the procedures used to establish the Internet links between our Teaching Laboratory and the Accelerator Laboratory will be discussed.

  1. Project development laboratories energy fuels and oils based on NRU “MPEI”

    Science.gov (United States)

    Burakov, I. A.; Burakov, A. Y.; Nikitina, I. S.; Khomenkov, A. M.; Paramonova, A. O.; Khtoo Naing, Aung

    2017-11-01

    In the process of improving the efficiency of power plants a hot topic is the use of high-quality fuels and lubricants. In the process of transportation, preparation for use, storage and maintenance of the properties of fuels and lubricants may deteriorate, which entails a reduction in the efficiency of power plants. One of the ways to prevent the deterioration of the properties is a timely analysis of the relevant laboratories. In this day, the existence of laboratories of energy fuels and energy laboratory oil at thermal power stations is satisfactory character. However, the training of qualified personnel to work in these laboratories is a serious problem, as the lack of opportunities in these laboratories a complete list of required tests. The solution to this problem is to explore the possibility of application of methods of analysis of the properties of fuels and lubricants in the stage of training and re-training of qualified personnel. In this regard, on the basis of MPEI developed laboratory projects of solid, liquid and gaseous fuels, power and energy oils and lubricants. Projects allow for a complete list of tests required for the timely control of properties and prevent the deterioration of these properties. Assess the financial component of the implementation of the developed projects based on the use of modern equipment used for tests. Projects allow for a complete list of tests required for the timely control of properties and prevent the deterioration of these properties.

  2. Accelerator-based techniques for the support of senior-level undergraduate physics laboratories

    International Nuclear Information System (INIS)

    Williams, J.R.; Clark, J.C.; Isaacs-Smith, T.

    2001-01-01

    Approximately three years ago, Auburn University replaced its aging Dynamitron accelerator with a new 2MV tandem machine (Pelletron) manufactured by the National Electrostatics Corporation (NEC). This new machine is maintained and operated for the University by Physics Department personnel, and the accelerator supports a wide variety of materials modification/analysis studies. Computer software is available that allows the NEC Pelletron to be operated from a remote location, and an Internet link has been established between the Accelerator Laboratory and the Upper-Level Undergraduate Teaching Laboratory in the Physics Department. Additional software supplied by Canberra Industries has also been used to create a second Internet link that allows live-time data acquisition in the Teaching Laboratory. Our senior-level undergraduates and first-year graduate students perform a number of experiments related to radiation detection and measurement as well as several standard accelerator-based experiments that have been added recently. These laboratory exercises will be described, and the procedures used to establish the Internet links between our Teaching Laboratory and the Accelerator Laboratory will be discussed

  3. SOA Meets Robots - A Service-Based Software Infrastructure for Remote Laboratories

    Directory of Open Access Journals (Sweden)

    Frank Feinbube

    2008-05-01

    Full Text Available With the ongoing internationalization of virtual laboratories, the integration aspect becomes more important. The meanwhile commonly accepted ’glue’ for such legacy systems are service oriented architectures, based on standardized and accepted Web service standards. We present our concept of the ’experiment as a service’, where the idea of service-based architectures is applied to virtual remote laboratories. In our laboratory middleware, experiments are represented as stateful service implementations and jobs as logical service instances of these implementations. We discuss performance, reliability, security and monitoring issues in this approach, and show how the resulting infrastructure - the Distributed Control Lab - is applied in the European VetTrend project.

  4. Multifunctional Nanowire/film Composites based Bi-modular Sensors for In-situ and Real-time High Temperature Gas Detection

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Pu-Xian; Lei, Yu

    2013-06-01

    This final report to the Department of Energy/National Energy Technology Laboratory for DE-FE0000870 covers the period from 2009 to June, 2013 and summarizes the main research accomplishments, which can be divided in sensing materials innovation, bimodular sensor demonstration, and new understanding and discoveries. As a matter of fact, we have successfully completed all the project tasks in June 1, 2013, and presented the final project review presentation on the 9th of July, 2013. Specifically, the major accomplishments achieved in this project include: 1) Successful development of a new class of high temperature stable gas sensor nanomaterials based on composite nano-array strategy in a 3D or 2D fashion using metal oxides and perovskite nanostructures. 2) Successful demonstration of bimodular nanosensors using 2D nanofibrous film and 3D composite nanowire arrays using electrical resistance mode and electrochemical electromotive force mode. 3) Series of new discoveries and understandings based on the new composite nanostructure platform toward enhancing nanosensor performance in terms of stability, selectivity, sensitivity and mass flux sensing. In this report, we highlight some results toward these accomplishments.

  5. Theta function identities associated with Ramanujan's modular ...

    Indian Academy of Sciences (India)

    that modular equations can be expressed as identities involving the theta functions φ, ψ and f . Therefore, often one first tries to derive a theta function identity and then transcribes it into an equivalent modular equation. But, proofs of some modular equations of composite degree 15 given by Berndt are quite unlike this ...

  6. Ramanujan's modular equations of degree 5

    Indian Academy of Sciences (India)

    Abstract. We provide alternative derivations of theta function identities associ- ated with modular equations of degree 5. We then use the identities to derive the corresponding modular equations. Keywords. Theta-function; elliptic integral; modular equation; multiplier. 1. Introduction. Ramanujan's general theta-function f (a, ...

  7. Integrity and change in modular ontologies

    NARCIS (Netherlands)

    Stuckenschmidt, Heiner; Klein, Michel

    2003-01-01

    The benefits of modular representations arc well known from many areas of computer science. In this paper, we concentrate on the benefits of modular ontologies with respect to local containment of terminological reasoning. We define an architecture for modular ontologies that supports local

  8. Is Laboratory Based Instruction in Beginning College-Level Chemistry Worth the Effort and Expense?

    Science.gov (United States)

    Hilosky, Alexandra; Sutman, Frank; Schmuckler, Joseph

    1998-01-01

    The authors report on one of a series of studies related to seeking a more effective role for laboratory experience in science instruction. This particular study addresses the status of laboratory based instruction in chemistry at the beginning college level for majors and nonmajors. The study is of interest to those who seek effective means of reforming beginning college level chemistry instruction in ways that give greater emphasis to laboratory based experiences. The study sample consists of 24 college chemistry instructors, and 3000 students from 24 laboratory sessions in 16 institutions of higher education (IHE) located throughout 5 states in the Northeast region of the U.S. An additional IHE in Germany was included for purposes of comparison because of the knowledge that the approach to chemistry instruction in Germany differed substantially from those practiced in the U.S. Pre-, post and actual laboratory sessions were videotaped. Teaching behaviors were analyzed and categorized using the validated MR-STBI (Modified-Revised Science Teacher Behavior Inventory). The fit between instructors' expectations and students' cognitive levels were also examined. This study describes 15 behaviors most and least frequently practiced; a comparison between U.S. and german instruction; and recommendations for instructional reform in the U.S.

  9. Laboratory-based surveillance in the molecular era: the TYPENED model, a joint data-sharing platform for clinical and public health laboratories.

    Science.gov (United States)

    Niesters, H G; Rossen, J W; van der Avoort, H; Baas, D; Benschop, K; Claas, E C; Kroneman, A; van Maarseveen, N; Pas, S; van Pelt, W; Rahamat-Langendoen, J C; Schuurman, R; Vennema, H; Verhoef, L; Wolthers, K; Koopmans, M

    2013-01-24

    Laboratory-based surveillance, one of the pillars of monitoring infectious disease trends, relies on data produced in clinical and/or public health laboratories. Currently, diagnostic laboratories worldwide submit strains or samples to a relatively small number of reference laboratories for characterisation and typing. However, with the introduction of molecular diagnostic methods and sequencing in most of the larger diagnostic and university hospital centres in high-income countries, the distinction between diagnostic and reference/public health laboratory functions has become less clear-cut. Given these developments, new ways of networking and data sharing are needed. Assuming that clinical and public health laboratories may be able to use the same data for their own purposes when sequence-based testing and typing are used, we explored ways to develop a collaborative approach and a jointly owned database (TYPENED) in the Netherlands. The rationale was that sequence data - whether produced to support clinical care or for surveillance -can be aggregated to meet both needs. Here we describe the development of the TYPENED approach and supporting infrastructure, and the implementation of a pilot laboratory network sharing enterovirus sequences and metadata.

  10. Morphology Independent Learning in Modular Robots

    DEFF Research Database (Denmark)

    Christensen, David Johan; Bordignon, Mirko; Schultz, Ulrik Pagh

    2009-01-01

    Hand-coding locomotion controllers for modular robots is difficult due to their polymorphic nature. Instead, we propose to use a simple and distributed reinforcement learning strategy. ATRON modules with identical controllers can be assembled in any configuration. To optimize the robot’s locomotion...... speed its modules independently and in parallel adjust their behavior based on a single global reward signal. In simulation, we study the learning strategy’s performance on different robot configurations. On the physical platform, we perform learning experiments with ATRON robots learning to move as fast...

  11. Some Learning Properties of Modular Network SOMs

    Science.gov (United States)

    Takeda, Manabu; Ikeda, Kazushi; Furukawa, Tetsuo

    The Modular Network Self-Organizing Map (mnSOM) is a generalization of the SOM, where each node represents a parametric function such as a multi-layer perceptron or another SOM. Since given datasets are, in general, fewer than nodes, some nodes never win in competition and have to update their parameters from the winners in the neighborhood. This is a process that can be regarded as interpolation. This study derives the interpolation curve between winners in simple cases and discusses the distribution of winners based on the neighborhood function.

  12. Synchronous Control of Modular Multilevel Converters

    DEFF Research Database (Denmark)

    Oleschuk, Valentin; Blaabjerg, Frede; Bose, Bimal K.

    2002-01-01

    A novel method of direct synchronous pulsewidth modulation (PWM) is applied for control of modular multilevel converters consisting from three standard triphase inverter modules along with an 0.33 p.u. output transformer. The proposed method provides synchronisation of the voltage waveforms...... for each module and the composed voltage at the output of the converter. Multilevel output voltage of the converter has quarter-wave symmetry during the whole range including the zone of overmodulation. Both continuous and discontinuous versions of synchronous PWM, based on vector approach...

  13. A qualitative case study of instructional support for web-based simulated laboratory exercises in online college chemistry laboratory courses

    Science.gov (United States)

    Schulman, Kathleen M.

    This study fills a gap in the research literature regarding the types of instructional support provided by instructors in online introductory chemistry laboratory courses that employ chemistry simulations as laboratory exercises. It also provides information regarding students' perceptions of the effectiveness of that instructional support. A multiple case study methodology was used to carry out the research. Two online introductory chemistry courses were studied at two community colleges. Data for this study was collected using phone interviews with faculty and student participants, surveys completed by students, and direct observation of the instructional designs of instructional support in the online Blackboard web sites and the chemistry simulations used by the participating institutions. The results indicated that the instructors provided multiple types of instructional support that correlated with forms of effective instructional support identified in the research literature, such as timely detailed feedback, detailed instructions for the laboratory experiments, and consistency in the instructional design of lecture and laboratory course materials, including the chemistry lab simulation environment. The students in one of these courses identified the following as the most effective types of instructional support provided: the instructor's feedback, opportunities to apply chemistry knowledge in the chemistry lab exercises, detailed procedures for the simulated laboratory exercises, the organization of the course Blackboard sites and the chemistry lab simulation web sites, and the textbook homework web sites. Students also identified components of instructional support they felt were missing. These included a desire for more interaction with the instructor, more support for the simulated laboratory exercises from the instructor and the developer of the chemistry simulations, and faster help with questions about the laboratory exercises or experimental

  14. Modular forms a classical approach

    CERN Document Server

    Cohen, Henri

    2017-01-01

    The theory of modular forms is a fundamental tool used in many areas of mathematics and physics. It is also a very concrete and "fun" subject in itself and abounds with an amazing number of surprising identities. This comprehensive textbook, which includes numerous exercises, aims to give a complete picture of the classical aspects of the subject, with an emphasis on explicit formulas. After a number of motivating examples such as elliptic functions and theta functions, the modular group, its subgroups, and general aspects of holomorphic and nonholomorphic modular forms are explained, with an emphasis on explicit examples. The heart of the book is the classical theory developed by Hecke and continued up to the Atkin-Lehner-Li theory of newforms and including the theory of Eisenstein series, Rankin-Selberg theory, and a more general theory of theta series including the Weil representation. The final chapter explores in some detail more general types of modular forms such as half-integral weight, Hilbert, Jacob...

  15. Rapidly Deployed Modular Telemetry System

    Science.gov (United States)

    Varnavas, Kosta A. (Inventor); Sims, William Herbert, III (Inventor)

    2013-01-01

    The present invention is a telemetry system, and more specifically is a rapidly deployed modular telemetry apparatus which utilizes of SDR technology and the FPGA programming capability to reduce the number of hardware components and programming required to deploy a telemetry system.

  16. Hierarchy of modular graph identities

    Energy Technology Data Exchange (ETDEWEB)

    D’Hoker, Eric; Kaidi, Justin [Mani L. Bhaumik Institute for Theoretical Physics, Department of Physics and Astronomy,University of California,Los Angeles, CA 90095 (United States)

    2016-11-09

    The low energy expansion of Type II superstring amplitudes at genus one is organized in terms of modular graph functions associated with Feynman graphs of a conformal scalar field on the torus. In earlier work, surprising identities between two-loop graphs at all weights, and between higher-loop graphs of weights four and five were constructed. In the present paper, these results are generalized in two complementary directions. First, all identities at weight six and all dihedral identities at weight seven are obtained and proven. Whenever the Laurent polynomial at the cusp is available, the form of these identities confirms the pattern by which the vanishing of the Laurent polynomial governs the full modular identity. Second, the family of modular graph functions is extended to include all graphs with derivative couplings and worldsheet fermions. These extended families of modular graph functions are shown to obey a hierarchy of inhomogeneous Laplace eigenvalue equations. The eigenvalues are calculated analytically for the simplest infinite sub-families and obtained by Maple for successively more complicated sub-families. The spectrum is shown to consist solely of eigenvalues s(s−1) for positive integers s bounded by the weight, with multiplicities which exhibit rich representation-theoretic patterns.

  17. "Boxnep" advanced modular underwater robot

    OpenAIRE

    Buluev, Ilia

    2016-01-01

    The article discusses the relevance of the underwater vehicles' ability to solve a wide range of problems. The idea put in the basis of this research is designing a modular underwater robot. It allows to mount various equipment and test it in underwater environment. The paper deals with the concept of the robot and its characteristics.

  18. Modular networks with hierarchical organization

    Indian Academy of Sciences (India)

    Several networks occurring in real life have modular structures that are arranged in a hierarchical fashion. In this paper, we have proposed a model for such networks, using a stochastic generation method. Using this model we show that, the scaling relation between the clustering and degree of the nodes is not a necessary ...

  19. Modular crystals as modulated structures

    DEFF Research Database (Denmark)

    Elcoro, L.; Perez-Mato, J.M.; Friese, K.

    2008-01-01

    The use of the superspace formalism is extended to the description and refinement of the homologous series of modular structures with two symmetry-related modules with different orientations. The lillianite homologous series has been taken as a study case. Starting from a commensurate modulated c...

  20. Transitioning from Expository Laboratory Experiments to Course-Based Undergraduate Research in General Chemistry

    Science.gov (United States)

    Clark, Ted M.; Ricciardo, Rebecca; Weaver, Tyler

    2016-01-01

    General chemistry courses predominantly use expository experiments that shape student expectations of what a laboratory activity entails. Shifting within a semester to course-based undergraduate research activities that include greater decision-making, collaborative work, and "messy" real-world data necessitates a change in student…

  1. Laboratory-based grain-shape models for simulating dust infrared spectra

    NARCIS (Netherlands)

    Mutschke, H.; Min, M.; Tamanai, A.

    2009-01-01

    Context. Analysis of thermal dust emission spectra for dust mineralogy and physical grain properties depends on comparison spectra, which are either laboratory-measured infrared extinction spectra or calculated extinction cross sections based on certain grain models. Often, the agreement between

  2. A Metabolic Murder Mystery: A Case-Based Experiment for the Undergraduate Biochemistry Laboratory

    Science.gov (United States)

    Childs-Disney, Jessica L.; Kauffmann, Andrew D.; Poplawski, Shane G.; Lysiak, Daniel R.; Stewart, Robert J.; Arcadi, Jane K.; Dinan, Frank J.

    2010-01-01

    In 1990, a woman was wrongly convicted of poisoning her infant son and was sentenced to life in prison. Her conviction was based on laboratory work that wrongly identified ethylene glycol as present in her son's blood and in the formula he drank prior to his death. The actual cause of the infant's death, a metabolic disease, was eventually…

  3. Formalizing the First Day in an Organic Chemistry Laboratory Using a Studio-Based Approach

    Science.gov (United States)

    Collison, Christina G.; Cody, Jeremy; Smith, Darren; Swartzenberg, Jennifer

    2015-01-01

    A novel studio-based lab module that incorporates student-centered activities was designed and implemented to introduce second-year undergraduate students to the first-semester organic chemistry laboratory. The "First Day" studio module incorporates learning objectives for the course, lab safety, and keeping a professional lab notebook.

  4. Students Dig Deep in the Mystery Soil Lab: A Playful, Inquiry-Based Soil Laboratory Project

    Science.gov (United States)

    Thiet, Rachel K.

    2014-01-01

    The Mystery Soil Lab, a playful, inquiry-based laboratory project, is designed to develop students' skills of inquiry, soil analysis, and synthesis of foundational concepts in soil science and soil ecology. Student groups are given the charge to explore and identify a "Mystery Soil" collected from a unique landscape within a 10-mile…

  5. Microwave-Assisted Esterification: A Discovery-Based Microscale Laboratory Experiment

    Science.gov (United States)

    Reilly, Maureen K.; King, Ryan P.; Wagner, Alexander J.; King, Susan M.

    2014-01-01

    An undergraduate organic chemistry laboratory experiment has been developed that features a discovery-based microscale Fischer esterification utilizing a microwave reactor. Students individually synthesize a unique ester from known sets of alcohols and carboxylic acids. Each student identifies the best reaction conditions given their particular…

  6. Model-based fuzzy control solutions for a laboratory Antilock Braking System

    DEFF Research Database (Denmark)

    Precup, Radu-Emil; Spataru, Sergiu; Rǎdac, Mircea-Bogdan

    2010-01-01

    This paper gives two original model-based fuzzy control solutions dedicated to the longitudinal slip control of Antilock Braking System laboratory equipment. The parallel distributed compensation leads to linear matrix inequalities which guarantee the global stability of the fuzzy control systems....... Real-time experimental results validate the new fuzzy control solutions....

  7. A Laboratory Experiment, Based on the Maillard Reaction, Conducted as a Project in Introductory Statistics

    Science.gov (United States)

    Kravchuk, Olena; Elliott, Antony; Bhandari, Bhesh

    2005-01-01

    A simple laboratory experiment, based on the Maillard reaction, served as a project in Introductory Statistics for undergraduates in Food Science and Technology. By using the principles of randomization and replication and reflecting on the sources of variation in the experimental data, students reinforced the statistical concepts and techniques…

  8. Incorporating Course-Based Undergraduate Research Experiences into Analytical Chemistry Laboratory Curricula

    Science.gov (United States)

    Kerr, Melissa A.; Yan, Fei

    2016-01-01

    A continuous effort within an undergraduate university setting is to improve students' learning outcomes and thus improve students' attitudes about a particular field of study. This is undoubtedly relevant within a chemistry laboratory. This paper reports the results of an effort to introduce a problem-based learning strategy into the analytical…

  9. A Simple System for Observing Dynamic Phase Equilibrium via an Inquiry-Based Laboratory or Demonstration

    Science.gov (United States)

    Cloonan, Carrie A.; Andrew, Julie A.; Nichol, Carolyn A.; Hutchinson, John S.

    2011-01-01

    This article describes an activity that can be used as an inquiry-based laboratory or demonstration for either high school or undergraduate chemistry students to provide a basis for understanding both vapor pressure and the concept of dynamic phase equilibrium. The activity includes a simple setup to create a closed system of only water liquid and…

  10. Unraveling the disease consequences and mechanisms of modular structure in animal social networks.

    Science.gov (United States)

    Sah, Pratha; Leu, Stephan T; Cross, Paul C; Hudson, Peter J; Bansal, Shweta

    2017-04-18

    Disease risk is a potential cost of group living. Although modular organization is thought to reduce this cost in animal societies, empirical evidence toward this hypothesis has been conflicting. We analyzed empirical social networks from 43 animal species to motivate our study of the epidemiological consequences of modular structure in animal societies. From these empirical studies, we identified the features of interaction patterns associated with network modularity and developed a theoretical network model to investigate when and how subdivisions in social networks influence disease dynamics. Contrary to prior work, we found that disease risk is largely unaffected by modular structure, although social networks beyond a modular threshold experience smaller disease burden and longer disease duration. Our results illustrate that the lowering of disease burden in highly modular social networks is driven by two mechanisms of modular organization: network fragmentation and subgroup cohesion. Highly fragmented social networks with cohesive subgroups are able to structurally trap infections within a few subgroups and also cause a structural delay to the spread of disease outbreaks. Finally, we show that network models incorporating modular structure are necessary only when prior knowledge suggests that interactions within the population are highly subdivided. Otherwise, null networks based on basic knowledge about group size and local contact heterogeneity may be sufficient when data-limited estimates of epidemic consequences are necessary. Overall, our work does not support the hypothesis that modular structure universally mitigates the disease impact of group living.

  11. Unraveling the disease consequences and mechanisms of modular structure in animal social networks

    Science.gov (United States)

    Sah, Pratha; Leu, Stephan T.; Cross, Paul C.; Hudson, Peter J.; Bansal, Shweta

    2017-01-01

    Disease risk is a potential cost of group living. Although modular organization is thought to reduce this cost in animal societies, empirical evidence toward this hypothesis has been conflicting. We analyzed empirical social networks from 43 animal species to motivate our study of the epidemiological consequences of modular structure in animal societies. From these empirical studies, we identified the features of interaction patterns associated with network modularity and developed a theoretical network model to investigate when and how subdivisions in social networks influence disease dynamics. Contrary to prior work, we found that disease risk is largely unaffected by modular structure, although social networks beyond a modular threshold experience smaller disease burden and longer disease duration. Our results illustrate that the lowering of disease burden in highly modular social networks is driven by two mechanisms of modular organization: network fragmentation and subgroup cohesion. Highly fragmented social networks with cohesive subgroups are able to structurally trap infections within a few subgroups and also cause a structural delay to the spread of disease outbreaks. Finally, we show that network models incorporating modular structure are necessary only when prior knowledge suggests that interactions within the population are highly subdivided. Otherwise, null networks based on basic knowledge about group size and local contact heterogeneity may be sufficient when data-limited estimates of epidemic consequences are necessary. Overall, our work does not support the hypothesis that modular structure universally mitigates the disease impact of group living.

  12. Mechanical Design of Odin, an Extendable Heterogeneous Deformable Modular Robot

    DEFF Research Database (Denmark)

    Lyder, Andreas; Garcia, Ricardo Franco Mendoza; Støy, Kasper

    2008-01-01

    Highly sophisticated animals consist of a set of heterogenous modules decided by nature so that they can survive in a complex environment. In this paper we present a new modular robot inspired by biology called Odin. The Odin robot is based on a deformable lattice and consists of an extendable se...... of heterogeneous modules. We present the design and implementation of a cubic closed-packed (CCP) joint module, a telescoping link, and a flexible connection mechanism. The developed robot is highly versatile and opens up for a wide range of new research in modular robotics.......Highly sophisticated animals consist of a set of heterogenous modules decided by nature so that they can survive in a complex environment. In this paper we present a new modular robot inspired by biology called Odin. The Odin robot is based on a deformable lattice and consists of an extendable set...

  13. Effects of complex feedback on computer-assisted modular instruction

    NARCIS (Netherlands)

    Gordijn, Jan; Nijhof, W.J.

    2002-01-01

    The aim of this study is to determine the effects of two versions of Computer-Based Feedback within a prevocational system of modularized education in The Netherlands. The implementation and integration of Computer-Based Feedback (CBF) in Installation Technology modules in all schools (n=60) in The

  14. Comparability, stability, and reliability of internet-based mental chronometry in domestic and laboratory settings.

    Science.gov (United States)

    Miller, R; Schmidt, K; Kirschbaum, C; Enge, S

    2018-03-15

    The internet-based assessment of response time (RT) and error rate (ERR) has recently become a well-validated alternative to traditional laboratory-based assessment, because methodological research has provided evidence for negligible setting- and setup-related differences in RT and ERR measures of central tendency. However, corresponding data on potential differences in the variability of such performance measures are still lacking, to date. Hence, the aim of this study was to conduct internet-based mental chronometry in both poorly standardized domestic and highly standardized laboratory environments and to compare the variabilities of the corresponding performance measures. Using the Millisecond Inquisit4Web software, 127 men and women completed three different RT-based cognitive paradigms (i.e., go/no-go, two-back, and number-letter). Each participant completed all paradigms in two environments (i.e., at home and in the laboratory), with a time lag of seven days and in a counterbalanced order. Mixed-effects modeling was employed to estimate the between-setting variability across a comprehensive set of performance measures, including conventional measures of central tendency (i.e., mean RT and ERR) and further measures characterizing the joint distribution of RT/ERR. The latter measures were estimated using the diffusion model. The results suggested negligible differences between the domestic and laboratory settings. Thus, this study provides novel evidence suggesting that the statistical power of internet-based mental chronometry is commonly not compromised by increased environmental variance. The within- and between-session reliabilities were in a satisfactory range-that is, comparable to performance measures collected offline in laboratory settings. In consequence, our results support the broad applicability, robustness, and cost efficiency of mental chronometry assessment using the internet.

  15. Evaluation of the performance of existing non-laboratory based cardiovascular risk assessment algorithms

    Science.gov (United States)

    2013-01-01

    Background The high burden and rising incidence of cardiovascular disease (CVD) in resource constrained countries necessitates implementation of robust and pragmatic primary and secondary prevention strategies. Many current CVD management guidelines recommend absolute cardiovascular (CV) risk assessment as a clinically sound guide to preventive and treatment strategies. Development of non-laboratory based cardiovascular risk assessment algorithms enable absolute risk assessment in resource constrained countries. The objective of this review is to evaluate the performance of existing non-laboratory based CV risk assessment algorithms using the benchmarks for clinically useful CV risk assessment algorithms outlined by Cooney and colleagues. Methods A literature search to identify non-laboratory based risk prediction algorithms was performed in MEDLINE, CINAHL, Ovid Premier Nursing Journals Plus, and PubMed databases. The identified algorithms were evaluated using the benchmarks for clinically useful cardiovascular risk assessment algorithms outlined by Cooney and colleagues. Results Five non-laboratory based CV risk assessment algorithms were identified. The Gaziano and Framingham algorithms met the criteria for appropriateness of statistical methods used to derive the algorithms and endpoints. The Swedish Consultation, Framingham and Gaziano algorithms demonstrated good discrimination in derivation datasets. Only the Gaziano algorithm was externally validated where it had optimal discrimination. The Gaziano and WHO algorithms had chart formats which made them simple and user friendly for clinical application. Conclusion Both the Gaziano and Framingham non-laboratory based algorithms met most of the criteria outlined by Cooney and colleagues. External validation of the algorithms in diverse samples is needed to ascertain their performance and applicability to different populations and to enhance clinicians’ confidence in them. PMID:24373202

  16. Advanced Modular Inverter Technology Development

    Energy Technology Data Exchange (ETDEWEB)

    Adam Szczepanek

    2006-02-04

    tasks was to design and validate new gate drive circuits to provide the capability of high temp operation. The new power stages and controls were later validated through extensive performance, durability and environmental tests. To further validate the design, two power stages and controls were integrated into a grid-tied load bank test fixture, a real application for field-testing. This fixture was designed to test motor drives with PWM output up to 50kW. In the second part of this program the new control topology based on sub-phases control and interphase transformer technology was successfully developed and validated. The main advantage of this technology is to reduce magnetic mass, loss and current ripple. This report summarizes the results of the advanced modular inverter technology development and details: (1) Power stage development and fabrication (2) Power stage validation testing (3) Grid-tied test fixture fabrication and initial testing (4) Interphase transformer technology development

  17. Effects of Computer-Based Diagnostic Instruction and Non-Diagnostic Instruction on Laboratory Achievement in General Science.

    Science.gov (United States)

    McKenzie, Danny L.; Karnau, Sally A.

    The effects of computer-based diagnostic testing on the laboratory achievement of 91 preservice elementary teachers were assessed. These teachers were enrolled in one of four laboratory sections of a general science course. Intact classes were randomly assigned to one of two treatment groups. All students completed the same laboratory activities…

  18. Modular High Voltage Pulse Converter for Short Rise and Decay Times

    NARCIS (Netherlands)

    Mao, S.

    2018-01-01

    This thesis explores a modular HV pulse converter technology with short rise and decay times. A systematic methodology to derive and classify HV architectures based on a modularization level of power building blocks of the HV pulse converter is developed to summarize existing architectures and

  19. RFID based Anti-theft System for Metropolia UAS Electronics laboratories

    OpenAIRE

    Weldemedhin, Desta

    2016-01-01

    The aim of this thesis is to study different types of RFID based anti-Theft system implementation suitable for Metropolia Electronics laboratory environment to deter theft taking into account several installation requirements. The operating frequencies of the RFID anti-theft system are from low frequency to High frequencies range and governed by different standards based on the region it is going to be implemented. The introduction of this thesis will go through Radio Frequency Identifica...

  20. Cost evaluation of clinical laboratory in Taiwan's National Health System by using activity-based costing.

    Science.gov (United States)

    Su, Bin-Guang; Chen, Shao-Fen; Yeh, Shu-Hsing; Shih, Po-Wen; Lin, Ching-Chiang

    2016-11-01

    To cope with the government's policies to reduce medical costs, Taiwan's healthcare service providers are striving to survive by pursuing profit maximization through cost control. This article aimed to present the results of cost evaluation using activity-based costing performed in the laboratory in order to throw light on the differences between costs and the payment system of National Health Insurance (NHI). This study analyzed the data of costs and income of the clinical laboratory. Direct costs belong to their respective sections of the department. The department's shared costs, including public expenses and administrative assigned costs, were allocated to the department's respective sections. A simple regression equation was created to predict profit and loss, and evaluate the department's break-even point, fixed cost, and contribution margin ratio. In clinical chemistry and seroimmunology sections, the cost per test was lower than the NHI payment and their major laboratory tests had revenues with the profitability ratio of 8.7%, while the other sections had a higher cost per test than the NHI payment and their major tests were in deficit. The study found a simple linear regression model as follows: "Balance=-84,995+0.543×income (R2=0.544)". In order to avoid deficit, laboratories are suggested to increase test volumes, enhance laboratory test specialization, and become marginal scale. A hospital could integrate with regional medical institutions through alliances or OEM methods to increase volumes to reach marginal scale and reduce laboratory costs, enhancing the level and quality of laboratory medicine.

  1. [Aviation medicine laboratory of the North Fleet air base celebrates the 70th anniversary].

    Science.gov (United States)

    Gavrilov, V V; Mazaĭkin, D N; Buldakov, I M; Pisarev, A A

    2013-05-01

    The article is dedicated to the history of formation and development of the oldest aviation medicine department and its role in a flight safety of the North Fleet naval aviation. The aviation medicine laboratory was created in the years of the Great Patriotic war for medical backup of flights, medical review board, delivering of combat casualty care, prophylaxis of hypothermia and exhaustion of flight and ground crew. In a post-war period the aviation medicine laboratory made a great contribution to development of medical backup of educational and combat activity of the North Fleet aviation. Participation in cosmonaut applicants selection (incl. Yu.A. Gagarin), optimization of flight services during the transmeridian flights, research of carrier-based aircraft habitability and body state of the contingent during the longstanding ship-based aviation, development of treatment methods for functional status of sea-based aviation crew are the achievements of aviation medicine laboratory. Nowadays medicine laboratory is performing a research and practice, methodic and consultative activity with the aim of improving the system of medical backup, aviation medicine, psychology, flight safety, improvement of air crew health, prolong of flying proficiency.

  2. Inventory of data bases, graphics packages, and models in Department of Energy laboratories

    International Nuclear Information System (INIS)

    Shriner, C.R.; Peck, L.J.

    1978-11-01

    A central inventory of energy-related environmental bibliographic and numeric data bases, graphics packages, integrated hardware/software systems, and models was established at Oak Ridge National Laboratory in an effort to make these resources at Department of Energy (DOE) laboratories better known and available to researchers and managers. This inventory will also serve to identify and avoid duplication among laboratories. The data were collected at each DOE laboratory, then sent to ORNL and merged into a single file. This document contains the data from the merged file. The data descriptions are organized under major data types: data bases, graphics packages, integrated hardware/software systems, and models. The data include descriptions of subject content, documentation, and contact persons. Also provided are computer data such as media on which the item is available, size of the item, computer on which the item executes, minimum hardware configuration necessary to execute the item, software language(s) and/or data base management system utilized, and character set used. For the models, additional data are provided to define the model more accurately. These data include a general statement of algorithms, computational methods, and theories used by the model; organizations currently using the model; the general application area of the model; sources of data utilized by the model; model validation methods, sensitivity analysis, and procedures; and general model classification. Data in this inventory will be available for on-line data retrieval on the DOE/RECON system

  3. Concordance of programmatic and laboratory-based multidrug-resistant tuberculosis treatment outcomes in Peru.

    Science.gov (United States)

    Alexy, E R; Podewils, L J; Mitnick, C D; Becerra, M C; Laserson, K F; Bonilla, C

    2012-01-01

    Confirmation of cure for multidrug-resistant tuberculosis (MDR-TB) patients requires laboratory tests for Mycobacterium tuberculosis growth on culture media. Outcome decisions dictate patient management, and inaccuracies place patients at an increased risk of morbidity and mortality, and may contribute to continued transmission of MDR-TB. To examine concordance between programmatic and laboratory-based MDR-TB treatment outcomes. The study population included 1658 MDR-TB patients in Peru treated between 1996 and 2002 with both program and laboratory-based outcomes. Laboratory-based outcomes were assigned according to international standards requiring at least five consecutive negative cultures in the last 12 months of treatment to confirm cure. Compared to the global culture-defined standard classification, only 1.1% of treatment successes, but 54.3% of failures, were misclassified programmatically. Overall, 10.4% of patients identified by a clinician as having a successful treatment outcome still had cultures positive for MDR-TB. Most patients with successful treatment outcomes by strict culture definitions were also classified by clinicians as having successful outcomes. However, many culture-confirmed failures were missed. In light of delays and incomplete access to culture in MDR-TB programs, efforts should be made to improve the accuracy of programmatically determined treatment outcomes.

  4. Inquiry-based laboratory investigations and student performance on standardized tests in biological science

    Science.gov (United States)

    Patke, Usha

    Achievement data from the 3rd International Mathematics and Sciences Study and Program for International Student Assessment in science have indicated that Black students from economically disadvantaged families underachieve at alarming rates in comparison to White and economically advantaged peer groups. The study site was a predominately Black, urban school district experiencing underachievement. The purpose of this correlational study was to examine the relationship between students' use of inquiry-based laboratory investigations and their performance on the Biology End of Course Test, as well as to examine the relationship while partialling out the effects of student gender. Constructivist theory formed the theoretical foundation of the study. Students' perceived levels of experience with inquiry-based laboratory investigations were measured using the Laboratory Program Variable Inventory (LPVI) survey. LPVI scores of 256 students were correlated with test scores and were examined by student gender. The Pearson correlation coefficient revealed a small direct correlation between students' experience in inquiry-based laboratory investigation classes and standardized test scores on the Biology EOCT. A partial correlational analysis indicated that the correlation remained after controlling for gender. This study may prompt a change from teacher-centered to student-centered pedagogy at the local site in order to increase academic achievement for all students. The results of this study may also influence administrators and policy makers to initiate local, state, or nationwide curricular development. A change in curriculum may promote social change as students become more competent, and more able, to succeed in life beyond secondary school.

  5. Bundling Products and Services Through Modularization Strategies

    DEFF Research Database (Denmark)

    Bask, Anu; Hsuan, Juliana; Rajahonka, Mervi

    2012-01-01

    Modularity has been recognized as a powerful tool in improving the efficiency and management of product design and manufacturing. However, the integrated view on covering both, product and service modularity for product-service systems (PSS), is under researched. Therefore, in this paper our...... objective is to contribute to the PSS modularity. Thus, we describe configurations of PSSs and the bundling of products and services through modularization strategies. So far there have not been tools to analyze and determine the correct combinations of degrees of product and service modularities....

  6. A Laboratory Experiment Investigating Different Aspects of Catalase Activity in an Inquiry - Based Approach

    Science.gov (United States)

    Kimbrough, Doris R.; Magoun, Mary Ann; Langfur, Meg

    1997-02-01

    The action of the enzyme catalase on aqueous hydrogen peroxide to generate oxygen gas is a well-established demonstration (1-3). Catalase is typically obtained by aqueous extraction of a potato, and the potato extract is mixed together with 3% hydrogen peroxide. The oxygen that is produced can be collected over water. Variations on the procedure can demonstrate the dependence of catalytic activity on temperature or the presence of inhibitors (1, 2). The University of Colorado at Denver has used a version of this procedure as a laboratory in its second-semester course for nonmajors. Recently, students have been allowed to expand upon the procedures prescribed in the laboratory handout in an open-ended project format. We explored some of these variations in detail, and the results provided here offer ideas, centered around this laboratory, for open-ended projects that can be used in an inquiry-based approach.

  7. Revealing all: misleading self-disclosure rates in laboratory-based online research.

    Science.gov (United States)

    Callaghan, Diana E; Graff, Martin G; Davies, Joanne

    2013-09-01

    Laboratory-based experiments in online self-disclosure research may be inadvertently compromising the accuracy of research findings by influencing some of the factors known to affect self-disclosure behavior. Disclosure-orientated interviews conducted with 42 participants in the laboratory and in nonlaboratory settings revealed significantly greater breadth of self-disclosure in laboratory interviews, with message length and intimacy of content also strongly related. These findings suggest that a contrived online setting with a researcher presence may stimulate motivation for greater self-disclosure than would occur naturally in an online environment of an individual's choice. The implications of these findings are that researchers should consider the importance of experimental context and motivation in self-disclosure research.

  8. Recent ARC developments: Through modularity to interoperability

    Energy Technology Data Exchange (ETDEWEB)

    Smirnova, O; Cameron, D; Ellert, M; Groenager, M; Johansson, D; Kleist, J [NDGF, Kastruplundsgade 22, DK-2770 Kastrup (Denmark); Dobe, P; Joenemo, J; Konya, B [Lund University, Experimental High Energy Physics, Institute of Physics, Box 118, SE-22100 Lund (Sweden); Fraagaat, T; Konstantinov, A; Nilsen, J K; Saada, F Ould; Qiang, W; Read, A [University of Oslo, Department of Physics, P. O. Box 1048, Blindern, N-0316 Oslo (Norway); Kocan, M [Pavol Jozef Safarik University, Faculty of Science, Jesenna 5, SK-04000 Kosice (Slovakia); Marton, I; Nagy, Zs [NIIF/HUNGARNET, Victor Hugo 18-22, H-1132 Budapest (Hungary); Moeller, S [University of Luebeck, Inst. Of Neuro- and Bioinformatics, Ratzeburger Allee 160, D-23538 Luebeck (Germany); Mohn, B, E-mail: oxana.smirnova@hep.lu.s [Uppsala University, Department of Physics and Astronomy, Div. of Nuclear and Particle Physics, Box 535, SE-75121 Uppsala (Sweden)

    2010-04-01

    The Advanced Resource Connector (ARC) middleware introduced by NorduGrid is one of the basic Grid solutions used by scientists worldwide. While being well-proven in daily use by a wide variety of scientific applications at large-scale infrastructures like the Nordic DataGrid Facility (NDGF) and smaller scale projects, production ARC of today is still largely based on conventional Grid technologies and custom interfaces introduced a decade ago. In order to guarantee sustainability, true cross-system portability and standards-compliance based interoperability, the ARC community undertakes a massive effort of implementing modular Web Service (WS) approach into the middleware. With support from the EU KnowARC project, new components were introduced and the existing key ARC services got extended with WS technology based standard-compliant interfaces following a service-oriented architecture. Such components include the hosting environment framework, the resource-coupled execution service, the re-engineered client library, the self-healing storage solution and the peer-to-peer information system, to name a few. Gradual introduction of these new services and client tools into the production middleware releases is carried out together with NDGF and thus ensures a smooth transition to the next generation Grid middleware. Standard interfaces and modularity of the new component design are essential for ARC contributions to the planned Universal Middleware Distribution of the European Grid Initiative.

  9. Recent ARC developments: Through modularity to interoperability

    International Nuclear Information System (INIS)

    Smirnova, O; Cameron, D; Ellert, M; Groenager, M; Johansson, D; Kleist, J; Dobe, P; Joenemo, J; Konya, B; Fraagaat, T; Konstantinov, A; Nilsen, J K; Saada, F Ould; Qiang, W; Read, A; Kocan, M; Marton, I; Nagy, Zs; Moeller, S; Mohn, B

    2010-01-01

    The Advanced Resource Connector (ARC) middleware introduced by NorduGrid is one of the basic Grid solutions used by scientists worldwide. While being well-proven in daily use by a wide variety of scientific applications at large-scale infrastructures like the Nordic DataGrid Facility (NDGF) and smaller scale projects, production ARC of today is still largely based on conventional Grid technologies and custom interfaces introduced a decade ago. In order to guarantee sustainability, true cross-system portability and standards-compliance based interoperability, the ARC community undertakes a massive effort of implementing modular Web Service (WS) approach into the middleware. With support from the EU KnowARC project, new components were introduced and the existing key ARC services got extended with WS technology based standard-compliant interfaces following a service-oriented architecture. Such components include the hosting environment framework, the resource-coupled execution service, the re-engineered client library, the self-healing storage solution and the peer-to-peer information system, to name a few. Gradual introduction of these new services and client tools into the production middleware releases is carried out together with NDGF and thus ensures a smooth transition to the next generation Grid middleware. Standard interfaces and modularity of the new component design are essential for ARC contributions to the planned Universal Middleware Distribution of the European Grid Initiative.

  10. Modular inverse reinforcement learning for visuomotor behavior.

    Science.gov (United States)

    Rothkopf, Constantin A; Ballard, Dana H

    2013-08-01

    In a large variety of situations one would like to have an expressive and accurate model of observed animal or human behavior. While general purpose mathematical models may capture successfully properties of observed behavior, it is desirable to root models in biological facts. Because of ample empirical evidence for reward-based learning in visuomotor tasks, we use a computational model based on the assumption that the observed agent is balancing the costs and benefits of its behavior to meet its goals. This leads to using the framework of reinforcement learning, which additionally provides well-established algorithms for learning of visuomotor task solutions. To quantify the agent's goals as rewards implicit in the observed behavior, we propose to use inverse reinforcement learning, which quantifies the agent's goals as rewards implicit in the observed behavior. Based on the assumption of a modular cognitive architecture, we introduce a modular inverse reinforcement learning algorithm that estimates the relative reward contributions of the component tasks in navigation, consisting of following a path while avoiding obstacles and approaching targets. It is shown how to recover the component reward weights for individual tasks and that variability in observed trajectories can be explained succinctly through behavioral goals. It is demonstrated through simulations that good estimates can be obtained already with modest amounts of observation data, which in turn allows the prediction of behavior in novel configurations.

  11. Optical Beam Deflection Based AFM with Integrated Hardware and Software Platform for an Undergraduate Engineering Laboratory

    Directory of Open Access Journals (Sweden)

    Siu Hong Loh

    2017-02-01

    Full Text Available Atomic force microscopy (AFM has been used extensively in nanoscience research since its invention. Recently, many teaching laboratories in colleges, undergraduate institutions, and even high schools incorporate AFM as an effective teaching tool for nanoscience education. This paper presents an optical beam deflection (OBD based atomic force microscope, designed specifically for the undergraduate engineering laboratory as a teaching instrument. An electronic module for signal conditioning was built with components that are commonly available in an undergraduate electronic laboratory. In addition to off-the-shelf mechanical parts and optics, the design of custom-built mechanical parts waskept as simple as possible. Hence, the overall cost for the setup is greatly reduced. The AFM controller was developed using National Instruments Educational Laboratory Virtual Instrumentation Suite (NI ELVIS, an integrated hardware and software platform which can be programmed in LabVIEW. A simple yet effective control algorithm for scanning and feedback control was developed. Despite the use of an educational platform and low-cost components from the undergraduate laboratory, the developed AFM is capable of performing imaging in constant-force mode with submicron resolution and at reasonable scanning speed (approximately 18 min per image. Therefore, the AFM is suitable to be used as an educational tool for nanoscience. Moreover, the construction of the system can be a valuable educational experience for electronic and mechanical engineering students.

  12. The iFlow modelling framework v2.4: a modular idealized process-based model for flow and transport in estuaries

    Science.gov (United States)

    Dijkstra, Yoeri M.; Brouwer, Ronald L.; Schuttelaars, Henk M.; Schramkowski, George P.

    2017-07-01

    The iFlow modelling framework is a width-averaged model for the systematic analysis of the water motion and sediment transport processes in estuaries and tidal rivers. The distinctive solution method, a mathematical perturbation method, used in the model allows for identification of the effect of individual physical processes on the water motion and sediment transport and study of the sensitivity of these processes to model parameters. This distinction between processes provides a unique tool for interpreting and explaining hydrodynamic interactions and sediment trapping. iFlow also includes a large number of options to configure the model geometry and multiple choices of turbulence and salinity models. Additionally, the model contains auxiliary components, including one that facilitates easy and fast sensitivity studies. iFlow has a modular structure, which makes it easy to include, exclude or change individual model components, called modules. Depending on the required functionality for the application at hand, modules can be selected to construct anything from very simple quasi-linear models to rather complex models involving multiple non-linear interactions. This way, the model complexity can be adjusted to the application. Once the modules containing the required functionality are selected, the underlying model structure automatically ensures modules are called in the correct order. The model inserts iteration loops over groups of modules that are mutually dependent. iFlow also ensures a smooth coupling of modules using analytical and numerical solution methods. This way the model combines the speed and accuracy of analytical solutions with the versatility of numerical solution methods. In this paper we present the modular structure, solution method and two examples of the use of iFlow. In the examples we present two case studies, of the Yangtze and Scheldt rivers, demonstrating how iFlow facilitates the analysis of model results, the understanding of the

  13. Biotechnology by Design: An Introductory Level, Project-Based, Synthetic Biology Laboratory Program for Undergraduate Students

    Directory of Open Access Journals (Sweden)

    Dale L. Beach

    2015-08-01

    Full Text Available Synthetic biology offers an ideal opportunity to promote undergraduate laboratory courses with research-style projects, immersing students in an inquiry-based program that enhances the experience of the scientific process. We designed a semester-long, project-based laboratory curriculum using synthetic biology principles to develop a novel sensory device. Students develop subject matter knowledge of molecular genetics and practical skills relevant to molecular biology, recombinant DNA techniques, and information literacy. During the spring semesters of 2014 and 2015, the Synthetic Biology Laboratory Project was delivered to sophomore genetics courses. Using a cloning strategy based on standardized BioBrick genetic “parts,” students construct a “reporter plasmid” expressing a reporter gene (GFP controlled by a hybrid promoter regulated by the lac-repressor protein (lacI. In combination with a “sensor plasmid,” the production of the reporter phenotype is inhibited in the presence of a target environmental agent, arabinose. When arabinose is absent, constitutive GFP expression makes cells glow green. But the presence of arabinose activates a second promoter (pBAD to produce a lac-repressor protein that will inhibit GFP production. Student learning was assessed relative to five learning objectives, using a student survey administered at the beginning (pre-survey and end (post-survey of the course, and an additional 15 open-ended questions from five graded Progress Report assignments collected throughout the course. Students demonstrated significant learning gains (p < 0.05 for all learning outcomes. Ninety percent of students indicated that the Synthetic Biology Laboratory Project enhanced their understanding of molecular genetics. The laboratory project is highly adaptable for both introductory and advanced courses. Editor's Note:The ASM advocates that students must successfully demonstrate the ability to explain and practice safe

  14. To Compare the Effects of Computer Based Learning and the Laboratory Based Learning on Students' Achievement Regarding Electric Circuits

    Science.gov (United States)

    Bayrak, Bekir; Kanli, Uygar; Kandil Ingeç, Sebnem

    2007-01-01

    In this study, the research problem was: "Is the computer based physics instruction as effective as laboratory intensive physics instruction with regards to academic success on electric circuits 9th grade students?" For this research of experimental quality the design of pre-test and post-test are applied with an experiment and a control…

  15. Regional Information Group (RIG). Energy, environmental, and socioeconomic data bases and associated software at Oak Ridge National Laboratory

    International Nuclear Information System (INIS)

    Loebl, A.S.; Malthouse, N.S.; Shonka, D.B.; Ogle, M.C.; Johnson, M.L.

    1976-10-01

    A machine readable data base has been created by the Regional Information Group, Regional and Urban Studies Section, Energy Division, Oak Ridge National Laboratory, to provide documentation for the energy, environmental, and socioeconomic data bases and associated software maintained at Oak Ridge National Laboratory. This document is produced yearly by the Regional Information Group to describe the contents and organization of this data base

  16. Regional Information Group (RIG). Energy, environmental, and socioeconomic data bases and associated software at Oak Ridge National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Loebl, A.S.; Malthouse, N.S.; Shonka, D.B.; Ogle, M.C.; Johnson, M.L.

    1976-10-01

    A machine readable data base has been created by the Regional Information Group, Regional and Urban Studies Section, Energy Division, Oak Ridge National Laboratory, to provide documentation for the energy, environmental, and socioeconomic data bases and associated software maintained at Oak Ridge National Laboratory. This document is produced yearly by the Regional Information Group to describe the contents and organization of this data base.

  17. Pre-Nursing Students Perceptions of Traditional and Inquiry Based Chemistry Laboratories

    Science.gov (United States)

    Rogers, Jessica

    This paper describes a process that attempted to meet the needs of undergraduate students in a pre-nursing chemistry class. The laboratory was taught in traditional verification style and students were surveyed to assess their perceptions of the educational goals of the laboratory. A literature review resulted in an inquiry based method and analysis of the needs of nurses resulted in more application based activities. This new inquiry format was implemented the next semester, the students were surveyed at the end of the semester and results were compared to the previous method. Student and instructor response to the change in format was positive. Students in the traditional format placed goals concerning technique above critical thinking and felt the lab was easy to understand and carry out. Students in the inquiry based lab felt they learned more critical thinking skills and enjoyed the independence of designing experiments and answering their own questions.

  18. Problem-based learning in laboratory medicine resident education: a satisfaction survey.

    Science.gov (United States)

    Lepiller, Quentin; Solis, Morgane; Velay, Aurélie; Gantner, Pierre; Sueur, Charlotte; Stoll-Keller, Françoise; Barth, Heidi; Fafi-Kremer, Samira

    2017-04-01

    Theoretical knowledge in biology and medicine plays a substantial role in laboratory medicine resident education. In this study, we assessed the contribution of problem-based learning (PBL) to improve the training of laboratory medicine residents during their internship in the department of virology, Strasbourg University Hospital, France. We compared the residents' satisfaction regarding an educational program based on PBL and a program based on lectures and presentations. PBL induced a high level of satisfaction (100%) among residents compared to lectures and presentations (53%). The main advantages of this technique were to create a situational interest regarding virological problems, to boost the residents' motivation and to help them identify the most relevant learning objectives in virology. However, it appears pertinent to educate the residents in appropriate bibliographic research techniques prior to PBL use and to monitor their learning by regular formative assessment sessions.

  19. A Simplified, Light Emitting Diode (LED Based, Modular System to be Used for the Rapid Evaluation of Fruit and Vegetable Quality: Development and Validation on Dye Solutions

    Directory of Open Access Journals (Sweden)

    Raffaele Civelli

    2015-09-01

    Full Text Available NIR spectroscopy has proven to be one of the most efficient and ready to transfer tools to monitor product’s quality. Portable VIS/NIR instruments are particularly versatile and suitable for field use to monitor the ripening process or quality parameters. The aim of this work is to develop and evaluate a new simplified optoelectronic system for potential measurements on fruit and vegetables directly in the field. The development, characterization and validation of an operative prototype is discussed. LED technology was chosen for the design, and spectral acquisition at four specific wavelengths (630, 690, 750 and 850 nm was proposed. Nevertheless, attention was given to the modularity and versatility of the system. Indeed, the possibility to change the light sources module with other wavelengths allows one to adapt the use of the same device for different foreseeable applications and objectives, e.g., ripeness evaluation, detection of particular diseases and disorders, chemical and physical property prediction, shelf life analysis, as well as for different natures of products (berry, leaf or liquid. Validation tests on blue dye water solutions have shown the capability of the system of discriminating low levels of reflectance, with a repeatability characterized by a standard deviation proportional to the measured intensity and in general limited to 2%–4%.

  20. A Modular and Affordable Time-Lapse Imaging and Incubation System Based on 3D-Printed Parts, a Smartphone, and Off-The-Shelf Electronics.

    Science.gov (United States)

    Hernández Vera, Rodrigo; Schwan, Emil; Fatsis-Kavalopoulos, Nikos; Kreuger, Johan

    2016-01-01

    Time-lapse imaging is a powerful tool for studying cellular dynamics and cell behavior over long periods of time to acquire detailed functional information. However, commercially available time-lapse imaging systems are expensive and this has limited a broader implementation of this technique in low-resource environments. Further, the availability of time-lapse imaging systems often present workflow bottlenecks in well-funded institutions. To address these limitations we have designed a modular and affordable time-lapse imaging and incubation system (ATLIS). The ATLIS enables the transformation of simple inverted microscopes into live cell imaging systems using custom-designed 3D-printed parts, a smartphone, and off-the-shelf electronic components. We demonstrate that the ATLIS provides stable environmental conditions to support normal cell behavior during live imaging experiments in both traditional and evaporation-sensitive microfluidic cell culture systems. Thus, the system presented here has the potential to increase the accessibility of time-lapse microscopy of living cells for the wider research community.

  1. A Hybrid Modular Multilevel Converter with Partial Embedded Energy Storage

    Directory of Open Access Journals (Sweden)

    Georgios Konstantinou

    2016-11-01

    Full Text Available Modular and cascaded multilevel converters provide a functional solution for the integration of energy storage systems (ESSs. This paper develops a hybrid multilevel converter based on the modular multilevel converter (MMC that can be functionally extended with partial embedded ESS as a fraction of the overall converter power rating. The configuration, which can operate as a typical DC-AC converter, enables multi-directional power flow between the DC- and AC-side of the converter, as well as the embedded energy storage elements. The use of a three-phase flying-capacitor submodule eliminates the second-order harmonic oscillations present in modular cascaded multilevel converters. Current, voltage and power control are discussed in the paper while simulation results illustrate the operation of the hybrid MMC as a DC-AC converter in a typical inverter application and the additional functions and control of the embedded ESS.

  2. IT PROJECT PORTFOLIO MANAGEMENT: MODULARITY PROBLEMS IN A PUBLIC ORGANIZATION

    DEFF Research Database (Denmark)

    Hansen, Lars Kristian; Mengiste, Shegaw Anagaw

    2012-01-01

    As today’s public and private sector organizations heavily rely on Information Technology (IT) to provide faster cycle times and better services, IT Project Portfolio Management (IT PPM) has become a high priority issue. This research adopts engaged scholarship to investigate IT PPM practices......, and (2) what modularity mechanisms can be recommended to improve IT PPM? By drawing on the theory’s distinction between visible information and Hidden design parameters five modularity problems are identified: (1) Lack of operational levels strategies, (2) No systematic approach to manage IT project...... information across units and sub units, (3) No standard processes for submitting IT projects proposals, (4) No centralized IT project selection process, and (5) Lack of centralized follow up process on IT Projects across units and subunits. Based on data and by using recommendations from Modularity theory, we...

  3. A control method for voltage balancing in modular multilevel converters

    DEFF Research Database (Denmark)

    Deng, Fujin; Chen, Zhe

    2014-01-01

    The modular multilevel converter (MMC) is attractive for medium- or high-power applications because of the advantages of its high modularity, availability, and high power quality. The voltage balancing of the floating capacitors in the cascaded submodules of the MMC is a key issue. In this paper......, a voltage-balancing control method is proposed. This method uses the phase-shifted carrier-based pulsewidth modulation scheme to control high-frequency current components for capacitor voltage balancing in the MMC without measuring the arm currents. Simulations and experimental studies of the MMC were...... conducted, and the results confirm the effectiveness of the proposed capacitor voltage-balancing control method....

  4. Application of Network Analysis for Characterizing Service Modularity

    DEFF Research Database (Denmark)

    Frandsen, Thomas

    2012-01-01

    The purpose of this paper is to explore the potential of the application of network analytical techniques to identify and characterize modularity of service processes. Services can be conceptualized as systems of interrelated components which can be decomposed in order to achieve a modular design....... The paper is based on a network theory perspective to the quantification and visualization of service process architectures. Metrics are considered in order to evaluate their usefulness for academics and practitioners interested in understanding service system design. The paper suggests a number of metrics...... of importance for evaluating components and their interrelationships in service systems....

  5. Mechanical Design of Odin, an Extendable Heterogeneous Deformable Modular Robot

    DEFF Research Database (Denmark)

    Lyder, Andreas; Garcia, Ricardo Franco Mendoza; Støy, Kasper

    2008-01-01

    Highly sophisticated animals consist of a set of heterogenous modules decided by nature so that they can survive in a complex environment. In this paper we present a new modular robot inspired by biology called Odin. The Odin robot is based on a deformable lattice and consists of an extendable se...... of heterogeneous modules. We present the design and implementation of a cubic closed-packed (CCP) joint module, a telescoping link, and a flexible connection mechanism. The developed robot is highly versatile and opens up for a wide range of new research in modular robotics....

  6. Sambot II: A self-assembly modular swarm robot

    Science.gov (United States)

    Zhang, Yuchao; Wei, Hongxing; Yang, Bo; Jiang, Cancan

    2018-04-01

    The new generation of self-assembly modular swarm robot Sambot II, based on the original generation of self-assembly modular swarm robot Sambot, adopting laser and camera module for information collecting, is introduced in this manuscript. The visual control algorithm of Sambot II is detailed and feasibility of the algorithm is verified by the laser and camera experiments. At the end of this manuscript, autonomous docking experiments of two Sambot II robots are presented. The results of experiments are showed and analyzed to verify the feasibility of whole scheme of Sambot II.

  7. Application of Network Analysis for Characterizing Service Modularity

    DEFF Research Database (Denmark)

    Frandsen, Thomas

    2012-01-01

    The purpose of this paper is to explore the potential of the application of network analytical techniques to identify and characterize modularity of service processes. Services can be conceptualized as systems of interrelated components which can be decomposed in order to achieve a modular design....... The paper is based on a network theory perspective to the quantification and visualization of service process architectures. Metrics are considered in order to evaluate their usefulness for academics and practitioners interested in understanding service system design. The paper suggests a number of metrics...

  8. Product, Organizational and Performance Effects of Product Modularity

    DEFF Research Database (Denmark)

    Boer, Henrike Engele Elisabeth

    2014-01-01

    A lot has been written about the performance effects associated with implementing a higher degree of product modularity in a firm’s product portfolio. However, these findings are mostly based on case research in the electronics and automotive industries and have hardly been tested and generalized...... beyond these industries. To be able to establish whether firms not part of these industries would experience the same performance effects, survey research will be needed. To support future survey research, this paper proposes an operationalization of product modularity and details the link between...

  9. A modular platform for targeted RNAi therapeutics

    Science.gov (United States)

    Kedmi, Ranit; Veiga, Nuphar; Ramishetti, Srinivas; Goldsmith, Meir; Rosenblum, Daniel; Dammes, Niels; Hazan-Halevy, Inbal; Nahary, Limor; Leviatan-Ben-Arye, Shani; Harlev, Michael; Behlke, Mark; Benhar, Itai; Lieberman, Judy; Peer, Dan

    2018-01-01

    Previous studies have identified relevant genes and signalling pathways that are hampered in human disorders as potential candidates for therapeutics. Developing nucleic acid-based tools to manipulate gene expression, such as short interfering RNAs1-3 (siRNAs), opens up opportunities for personalized medicine. Yet, although major progress has been made in developing siRNA targeted delivery carriers, mainly by utilizing monoclonal antibodies (mAbs) for targeting4-8, their clinical translation has not occurred. This is in part because of the massive development and production requirements and the high batch-to-batch variability of current technologies, which rely on chemical conjugation. Here we present a self-assembled modular platform that enables the construction of a theoretically unlimited repertoire of siRNA targeted carriers. The self-assembly of the platform is based on a membrane-anchored lipoprotein that is incorporated into siRNA-loaded lipid nanoparticles that interact with the antibody crystallizable fragment (Fc) domain. We show that a simple switch of eight different mAbs redirects the specific uptake of siRNAs by diverse leukocyte subsets in vivo. The therapeutic potential of the platform is demonstrated in an inflammatory bowel disease model by targeting colon macrophages to reduce inflammatory symptoms, and in a Mantle Cell Lymphoma xenograft model by targeting cancer cells to induce cell death and improve survival. This modular delivery platform represents a milestone in the development of precision medicine.

  10. Characterization of Orbital Debris Photometric Properties Derived from Laboratory-Based Measurements

    Science.gov (United States)

    Cowardin, H.; Abercromby, K.; Barker, E.; Seitzer, P.; Schildknecht, T.

    2010-01-01

    To better characterize and model optical data acquired from ground-based telescopes, the Optical Measurements Center (OMC) at NASA/JSC attempts to emulate illumination conditions seen in space using equipment and techniques that parallel telescopic observations and source-target-sensor orientations. The OMC uses a 75 Watt Xenon arc lamp as a solar simulator, an SBIG CCD camera with standard Johnson/Bessel filters, and a robotic arm to simulate an object's position and rotation. The laboratory uses known shapes, materials suspected to be consistent with the orbital debris population, and three phase angles to best match the lighting conditions of the telescope based data. The fourteen objects studied in the laboratory are fragments or materials acquired through ground-tests of scaled-model satellites/rocket bodies as well as material samples in more/less "flight-ready" condition. All fragments were measured at 10 increments in a full 360 rotation at 6 , 36 , and 60 phase angles. This paper will investigate published color photometric data for a series of orbital debris targets and compare it to the empirical photometric measurements generated in the OMC. Using the data acquired over specific rotational angles through different filters (B, V, R, I), a color index is acquired (B-R, R-I). Using these values and their associated lightcurves, this laboratory data is compared to observational data obtained on the 1 m telescope of the Astronomical Institute of the University of Bern (AUIB), the 0.9 m operated by the Small- and Medium-Aperture Research Telescope System (SMARTS) Consortium and the Curtis-Schmidt 0.6 m Michigan Orbital Debris Space Debris Telescope both located at Cerro Tololo Inter-American Observatory (CTIO). An empirical based optical characterization model will be presented to provide preliminary correlations between laboratory based and telescope-based data in the context of classification of GEO debris objects.

  11. Psychology Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — This facility provides testing stations for computer-based assessment of cognitive and behavioral Warfighter performance. This 500 square foot configurable space can...

  12. A VME-based data acquisition system for nuclear physics and detector laboratories

    International Nuclear Information System (INIS)

    Fan Ruirui; Liang Xiaohua; Meng Xiangcheng

    2012-01-01

    In this paper,we report a laboratory DAQ system based on VME bus, for applications in nuclear physics and the detector tests. It uses a commercial ADC card and a single board computer as a crate controller. They are based on the VME bus.The software is based on the ROOT framework. A canvas window is employed for online monitoring, and the acquired data are stored as Histograms in a ROOT file. The data acquisition speed can rea MB/s. A spectrum of 241 Am 59 keV γ-ray collected with a CdZnTe detector is shown to demonstrate the system. (authors)

  13. Survey of biomedical and environental data bases, models, and integrated computer systems at Argonne National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Murarka, I.P.; Bodeau, D.J.; Scott, J.M.; Huebner, R.H.

    1978-08-01

    This document contains an inventory (index) of information resources pertaining to biomedical and environmental projects at Argonne National Laboratory--the information resources include a data base, model, or integrated computer system. Entries are categorized as models, numeric data bases, bibliographic data bases, or integrated hardware/software systems. Descriptions of the Information Coordination Focal Point (ICFP) program, the system for compiling this inventory, and the plans for continuing and expanding it are given, and suggestions for utilizing the services of the ICFP are outlined.

  14. Survey of biomedical and environental data bases, models, and integrated computer systems at Argonne National Laboratory

    International Nuclear Information System (INIS)

    Murarka, I.P.; Bodeau, D.J.; Scott, J.M.; Huebner, R.H.

    1978-08-01

    This document contains an inventory (index) of information resources pertaining to biomedical and environmental projects at Argonne National Laboratory--the information resources include a data base, model, or integrated computer system. Entries are categorized as models, numeric data bases, bibliographic data bases, or integrated hardware/software systems. Descriptions of the Information Coordination Focal Point (ICFP) program, the system for compiling this inventory, and the plans for continuing and expanding it are given, and suggestions for utilizing the services of the ICFP are outlined

  15. AP1000TM plant modularization

    International Nuclear Information System (INIS)

    Cantarero L, C.; Demetri, K. J.; Quintero C, F. P.

    2016-09-01

    The AP1000 TM plant is an 1100 M We pressurized water reactor (PWR) with passive safety features and extensive plant simplifications that enhance construction, operation, maintenance and safety. Modules are used extensively in the design of the AP1000 plant nuclear island. The AP1000 plant uses modern, modular-construction techniques for plant construction. The design incorporates vendor-designed skids and equipment packages, as well as large, multi-ton structural modules and special equipment modules. Modularization allows traditionally sequential construction tasks to be completed simultaneously. Factory-built modules can be installed at the site in a planned construction schedule. The modularized AP1000 plant allows many more construction activities to proceed in parallel. This reduces plant construction calendar time, thus lowering the costs of plant financing. Furthermore, performing less work onsite significantly reduces the amount of skilled field-craft labor, which costs more than shop labor. In addition to labor cost savings, doing more welding and fabrication in a factory environment raises the quality of work, allowing more scheduling flexibility and reducing the amount of specialized tools required onsite. The site layout for the AP1000 plant has been established to support modular construction and efficient operations during construction. The plant layout is compact, using less space than previous conventional plant layouts. This paper provides and overview of the AP1000 plant modules with an emphasis on structural modules. Currently the Westinghouse AP1000 plant has four units under construction in China and four units under construction in the United States. All have shown successful fabrication and installation of various AP1000 plant modules. (Author)

  16. CP violation and modular symmetries

    OpenAIRE

    Dent, Thomas

    2001-01-01

    We reconsider the origin of CP violation in fundamental theory. Existing string models of spontaneous CP violation make ambiguous predictions, due to the arbitrariness of CP transformation and the apparent non-invariance of the results under duality. We find an unambiguous modular CP invariance condition, applicable to predictive models of spontaneous CP violation, which circumvents these problems; it strongly constrains CP violation by heterotic string moduli. The dilaton is also evaluated a...

  17. A preliminary study of breast cancer diagnosis using laboratory based small angle x-ray scattering

    International Nuclear Information System (INIS)

    Round, A R; Wilkinson, S J; Hall, C J; Rogers, K D; Glatter, O; Wess, T; Ellis, I O

    2005-01-01

    Breast tissue collected from tumour samples and normal tissue from bi-lateral mastectomy procedures were examined using small angle x-ray scattering. Previous work has indicated that breast tissue disease diagnosis could be performed using small angle x-ray scattering (SAXS) from a synchrotron radiation source. The technique would be more useful to health services if it could be made to work using a conventional x-ray source. Consistent and reliable differences in x-ray scatter distributions were observed between samples from normal and tumour tissue samples using the laboratory based 'SAXSess' system. Albeit from a small number of samples, a sensitivity of 100% was obtained. This result encourages us to pursue the implementation of SAXS as a laboratory based diagnosis technique

  18. A preliminary study of breast cancer diagnosis using laboratory based small angle x-ray scattering

    Science.gov (United States)

    Round, A. R.; Wilkinson, S. J.; Hall, C. J.; Rogers, K. D.; Glatter, O.; Wess, T.; Ellis, I. O.

    2005-09-01

    Breast tissue collected from tumour samples and normal tissue from bi-lateral mastectomy procedures were examined using small angle x-ray scattering. Previous work has indicated that breast tissue disease diagnosis could be performed using small angle x-ray scattering (SAXS) from a synchrotron radiation source. The technique would be more useful to health services if it could be made to work using a conventional x-ray source. Consistent and reliable differences in x-ray scatter distributions were observed between samples from normal and tumour tissue samples using the laboratory based 'SAXSess' system. Albeit from a small number of samples, a sensitivity of 100% was obtained. This result encourages us to pursue the implementation of SAXS as a laboratory based diagnosis technique.

  19. A preliminary study of breast cancer diagnosis using laboratory based small angle x-ray scattering

    Energy Technology Data Exchange (ETDEWEB)

    Round, A R [Daresbury Laboratories, Warrington, WA4 4AD (United Kingdom); Wilkinson, S J [Daresbury Laboratories, Warrington, WA4 4AD (United Kingdom); Hall, C J [Daresbury Laboratories, Warrington, WA4 4AD (United Kingdom); Rogers, K D [Department of Materials and Medical Sciences, Cranfield University, Swindon, SN6 8LA (United Kingdom); Glatter, O [Department of Chemistry, University of Graz (Austria); Wess, T [School of Optometry and Vision Sciences, Cardiff University, Cardiff CF10 3NB, Wales (United Kingdom); Ellis, I O [Nottingham City Hospital, Nottingham (United Kingdom)

    2005-09-07

    Breast tissue collected from tumour samples and normal tissue from bi-lateral mastectomy procedures were examined using small angle x-ray scattering. Previous work has indicated that breast tissue disease diagnosis could be performed using small angle x-ray scattering (SAXS) from a synchrotron radiation source. The technique would be more useful to health services if it could be made to work using a conventional x-ray source. Consistent and reliable differences in x-ray scatter distributions were observed between samples from normal and tumour tissue samples using the laboratory based 'SAXSess' system. Albeit from a small number of samples, a sensitivity of 100% was obtained. This result encourages us to pursue the implementation of SAXS as a laboratory based diagnosis technique.

  20. Modular programming method at JAERI

    International Nuclear Information System (INIS)

    Asai, Kiyoshi; Katsuragi, Satoru

    1982-02-01

    In this report the histories, concepts and a method for the construction and maintenance of nuclear code systems of Japan Atomic Energy Research Institute (JAERI) are presented. The method is mainly consisted of novel computer features. The development process of the features and experiences with them which required many man-months and efforts of scientists and engineers of JAERI and a computer manufacturer are also described. One of the features is a file handling program named datapool. The program is being used in code systems which are under development at JAERI. The others are computer features such as dynamic linking, reentrant coding of Fortran programs, interactive programming facility, document editor, quick system output viewer and editor, flexible man-machine interactive Fortran executor, and selective use of time-sharing or batch oriented computer in an interactive porgramming environment. In 1980 JAERI has replaced its two old computer systems by three FACOM M-200 computer systems and they have such features as mentioned above. Since 1981 most code systems, or even big single codes can be changed to modular code systems even if the developers or users of the systems will not recognize the fact that they are using modular code systems. The purpose of this report is to describe our methodology of modular programming from aspects of computer features and some of their applications to nuclear codes to get sympathetic understanding of it from persons of organizations who are concerned with the effective use of computers, especially, in nuclear research fields. (author)

  1. Structured Inquiry-Based Learning: Drosophila GAL4 Enhancer Trap Characterization in an Undergraduate Laboratory Course

    OpenAIRE

    Dunne, Christopher R.; Cillo, Anthony R.; Glick, Danielle R.; John, Katherine; Johnson, Cody; Kanwal, Jaspinder; Malik, Brian T.; Mammano, Kristina; Petrovic, Stefan; Pfister, William; Rascoe, Alexander S.; Schrom, Diane; Shapiro, Scott; Simkins, Jeffrey W.; Strauss, David

    2014-01-01

    We have developed and tested two linked but separable structured inquiry exercises using a set of Drosophila melanogaster GAL4 enhancer trap strains for an upper-level undergraduate laboratory methods course at Bucknell University. In the first, students learn to perform inverse PCR to identify the genomic location of the GAL4 insertion, using FlyBase to identify flanking sequences and the primary literature to synthesize current knowledge regarding the nearest gene. In the second, we cross e...

  2. Community-Driven Standards-Based Electronic Laboratory Data-Sharing Networks

    OpenAIRE

    Zarcone, Patina; Nordenberg, Dale; Meigs, Michelle; Merrick, Ulrike; Jernigan, Daniel; Hinrichs, Steven H.

    2010-01-01

    Public health laboratories (PHLs) are critical components of the nation's health-care system, serving as stewards of valuable specimens, delivering important diagnostic results to support clinical and public health programs, supporting public health policy, and conducting research. This article discusses the need for and challenges of creating standards-based data-sharing networks across the PHL community, which led to the development of the PHL Interoperability Project (PHLIP). Launched by t...

  3. An Approach to Laboratory Cost Containment Using a Data Base Management System

    OpenAIRE

    Kaplan, E.; Boeckmann, A.; Sheiner, L.B.

    1981-01-01

    Numerous articles have emphasized the need to develop effective cost containment strategies for laboratory utilization. This paper discusses the construction and use of a prototype data base system to detect and verify the existence of conditionally useless tests, or CUTs. For the purposes of this paper, a conditionally useless test is defined to be a test which, under certain conditions, does not provide sufficient new or relevant information to offset its associated cost.

  4. A Modular Architecture for Developing Robots for Industrial Applications

    DEFF Research Database (Denmark)

    Faina, Andres; Orjales, Felix; Souto, Daniel

    2015-01-01

    This chapter is concerned with proposing ways to make feasible the use of robots in many sectors characterized by dynamic and unstructured environments. In particular, we are interested in addressing the problem through a new approach, based on modular robotics, to allow the fast deployment of ro...

  5. Modular Multilevel Converter Control Strategy with Fault Tolerance

    DEFF Research Database (Denmark)

    Teodorescu, Remus; Eni, Emanuel-Petre; Mathe, Laszlo

    2013-01-01

    The Modular Multilevel Converter (MMC) technology has recently emerged in VSC-HVDC applications where it demonstrated higher efficiency and fault tolerance compared to the classical 2-level topology. Due to the ability of MMC to connect to HV levels, MMC can be also used in transformerless STATCO...... communication infrastructure based on Industrial Ethernet....

  6. Nonlinear Control Structure of Grid Connected Modular Multilevel Converters

    DEFF Research Database (Denmark)

    Hajizadeh, Amin; Norum, Lars; Ahadpour Shal, Alireza

    2017-01-01

    This paper implements nonlinear control structure based on Adaptive Fuzzy Sliding Mode (AFSM) Current Control and Unscented Kalman Filter (UKF) to estimate the capacitor voltages from the measurement of arm currents of Modular Multilevel Converter (MMC). UKF use nonlinear unscented transforms in ...

  7. Modular program systems for scientific-technical programs

    International Nuclear Information System (INIS)

    Bennewitz, F.; Lembcke, R.

    1977-01-01

    In order to replace the numerous traditional stand alone codes, great modular data based systems were developed by KWU for the simulation of nuclear reactors. These latter systems exhibit a high degree of automatization and combine quality assurance with a high flexibility in special problems. On the other hand they show a greater mashine dependency. (orig.) [de

  8. A framework for laboratory pre-work based on the concepts, tools and techniques questioning method

    International Nuclear Information System (INIS)

    Huntula, J; Sharma, M D; Johnston, I; Chitaree, R

    2011-01-01

    Learning in the laboratory is different from learning in other contexts because students have to engage with various aspects of the practice of science. They have to use many skills and knowledge in parallel-not only to understand the concepts of physics but also to use the tools and analyse the data. The question arises, how to best guide students' learning in the laboratory. This study is about creating and using questions with a specifically designed framework to aid learning in the laboratory. The concepts, tools and techniques questioning (CTTQ) method was initially designed and used at Mahidol University, Thailand, and was subsequently extended to laboratory pre-work at the University of Sydney. The CTTQ method was implemented in Sydney with 190 first-year students. Three pre-work exercises on a series of electrical experiments were created based on the CTTQ method. The pre-works were completed individually and submitted before the experiment started. Analysed pre-work, surveys and interviews were used to evaluate the pre-work questions in this study. The results indicated that the CTTQ method was successful and the flow in the experiments was better than that in the previous year. At the same time students had difficulty with the last experiment in the sequence and with techniques.

  9. Mounted Smartphones as Measurement and Control Platforms for Motor-Based Laboratory Test-Beds †

    Science.gov (United States)

    Frank, Jared A.; Brill, Anthony; Kapila, Vikram

    2016-01-01

    Laboratory education in science and engineering often entails the use of test-beds equipped with costly peripherals for sensing, acquisition, storage, processing, and control of physical behavior. However, costly peripherals are no longer necessary to obtain precise measurements and achieve stable feedback control of test-beds. With smartphones performing diverse sensing and processing tasks, this study examines the feasibility of mounting smartphones directly to test-beds to exploit their embedded hardware and software in the measurement and control of the test-beds. This approach is a first step towards replacing laboratory-grade peripherals with more compact and affordable smartphone-based platforms, whose interactive user interfaces can engender wider participation and engagement from learners. Demonstrative cases are presented in which the sensing, computation, control, and user interaction with three motor-based test-beds are handled by a mounted smartphone. Results of experiments and simulations are used to validate the feasibility of mounted smartphones as measurement and feedback control platforms for motor-based laboratory test-beds, report the measurement precision and closed-loop performance achieved with such platforms, and address challenges in the development of platforms to maintain system stability. PMID:27556464

  10. Mounted Smartphones as Measurement and Control Platforms for Motor-Based Laboratory Test-Beds

    Directory of Open Access Journals (Sweden)

    Jared A. Frank

    2016-08-01

    Full Text Available Laboratory education in science and engineering often entails the use of test-beds equipped with costly peripherals for sensing, acquisition, storage, processing, and control of physical behavior. However, costly peripherals are no longer necessary to obtain precise measurements and achieve stable feedback control of test-beds. With smartphones performing diverse sensing and processing tasks, this study examines the feasibility of mounting smartphones directly to test-beds to exploit their embedded hardware and software in the measurement and control of the test-beds. This approach is a first step towards replacing laboratory-grade peripherals with more compact and affordable smartphone-based platforms, whose interactive user interfaces can engender wider participation and engagement from learners. Demonstrative cases are presented in which the sensing, computation, control, and user interaction with three motor-based test-beds are handled by a mounted smartphone. Results of experiments and simulations are used to validate the feasibility of mounted smartphones as measurement and feedback control platforms for motor-based laboratory test-beds, report the measurement precision and closed-loop performance achieved with such platforms, and address challenges in the development of platforms to maintain system stability.

  11. Modular packaging concept for MEMS and MOEMS

    Science.gov (United States)

    Stenchly, Vanessa; Reinert, Wolfgang; Quenzer, Hans-Joachim

    2017-11-01

    Wherever technical systems detect objects in their environment or interact with people, optical devices may play an important role. Light can be relatively easily produced and spatially and temporally modulated. Laser can project sharp images over long distances or cut materials in short distances. Depending on the wavelength an invisible scanning in near infrared for gesture recognition is possible as well as a projection of brilliant colour images. For several years, the Fraunhofer ISIT develops Opto-Packaging processes based on the viscous reshaping of glass wafers: First, hermetically sealed laser micro-mirror scanners WLP with inclined windows deflect in the central light reflex of the window out of the image area. Second, housing with lateral light exit permits hermetic sealing of edge-emitting lasers for highest reliability and durability. Such systems are currently experiencing an extremely high interest of the industry in all segments, from consumer to automotive through to materials processing. Our modular Opto-Packaging platform enables fast product developments. Housing for opto mechanical MEMS devices are equipped with inclined windows to minimize distortion, stray light and reflection losses. The hot viscous glass forming technology is also applied to functionalized substrate wafers which possess areas with high heat dissipation in addition to thermally insulating areas. Electrical contacts may be realized with metal filled vias or TGV (Through Glass Vias). The modular system reduces the development times for new, miniaturized optical systems so that manufacturers can focus on the essentials in their development, namely their product functionalities.

  12. Materials research at selected Japanese laboratories. Based on a 1992 visit: Overview, summary of highlights, notes on laboratories and topics

    Energy Technology Data Exchange (ETDEWEB)

    1994-02-01

    I visited Japan from June 29 to August 1, 1992. The purpose of this visit was to assess the status of materials science research at selected governmental, university and industrial laboratories and to established acquaintances with Japanese researchers. The areas of research covered by these visits included ceramics, oxide superconductors, intermetallics alloys, superhard materials and diamond films, high-temperature materials and properties, mechanical properties, fracture, creep, fatigue, defects, materials for nuclear reactor applications and irradiation effects, high pressure synthesis, self-propagating high temperature synthesis, microanalysis, magnetic properties and magnetic facilities, and surface science.

  13. Laboratory Building

    Energy Technology Data Exchange (ETDEWEB)

    Herrera, Joshua M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-03-01

    This report is an analysis of the means of egress and life safety requirements for the laboratory building. The building is located at Sandia National Laboratories (SNL) in Albuquerque, NM. The report includes a prescriptive-based analysis as well as a performance-based analysis. Following the analysis are appendices which contain maps of the laboratory building used throughout the analysis. The top of all the maps is assumed to be north.

  14. Modularity and its effects on innovation

    DEFF Research Database (Denmark)

    Boer, Henrike Engele Elisabeth; Hansen, Poul H. Kyvsgård

    systematic work and management type of tasks, although it conflicts with the typical characteristics associated with the entrepreneur. If not managed properly, modularization can foster the modularity trap over time. At this stage intrapreneurial activities can help the organization stay ahead of the game......Purpose Through a discussion of the link between modularity and innovation, it is assessed whether and, then, when it is appropriate for an entrepreneur to apply modularity in his company’s innovation processes. Design/Methodology/Approach A conceptual paper, which aims to combine three theoretical...... fields: Modularity, Innovation, and Entrepreneurship Findings: Modularization can provide huge advantages for entrepreneurs. However, the true benefits can first be pursued when the product and production processes are mature enough. At this point of time the entrepreneur will need to accept more...

  15. Modular Design in Treaty Verification Equipment

    Energy Technology Data Exchange (ETDEWEB)

    Macarthur, Duncan Whittemore [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Benz, Jacob [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Tolk, Keith [Milagro Consulting, Albuquerque, NM (United States); Weber, Tom [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-01-27

    It is widely believed that modular design is a good thing. However, there are often few explicit arguments, or even an agreed range of definitions, to back up this belief. In this paper, we examine the potential range of design modularity, the implications of various amounts of modularity, and the advantages and disadvantages of each level of modular construction. We conclude with a comparison of the advantages and disadvantages of each type, as well as discuss many caveats that should be observed to take advantage of the positive features of modularity and minimize the effects of the negative. The tradeoffs described in this paper will be evaluated during the conceptual design to determine what amount of modularity should be included.

  16. Modular properties of 6d (DELL) systems

    Science.gov (United States)

    Aminov, G.; Mironov, A.; Morozov, A.

    2017-11-01

    If super-Yang-Mills theory possesses the exact conformal invariance, there is an additional modular invariance under the change of the complex bare charge [InlineMediaObject not available: see fulltext.]. The low-energy Seiberg-Witten prepotential ℱ( a), however, is not explicitly invariant, because the flat moduli also change a - → a D = ∂ℱ/∂ a. In result, the prepotential is not a modular form and depends also on the anomalous Eisenstein series E 2. This dependence is usually described by the universal MNW modular anomaly equation. We demonstrate that, in the 6 d SU( N) theory with two independent modular parameters τ and \\widehat{τ} , the modular anomaly equation changes, because the modular transform of τ is accompanied by an ( N -dependent!) shift of \\widehat{τ} and vice versa. This is a new peculiarity of double-elliptic systems, which deserves further investigation.

  17. Modular Robotics in an African Context

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop

    2011-01-01

    In this paper, we review the concept, development and use of modular robotic devices for education, health improvements, and business in Africa. The modular robotics inspired technology has the advantage of allowing any user easy access to a physical construction of new and advanced technology. We...... conceptualized several educational tools inspired by modular robotics for contextualized IT education in Tanzania, leading to a novel IT degree program and the development of East Africa’s first science and business park in Iringa, Tanzania. The prototypes inspired by modular robotics were developed in the local......, rural context and tested by local users in hospitals and rehabilitation centres. In this paper, we review the development of both modular building blocks for education and modular robotic tiles for rehabilitation in Tanzania....

  18. (Automated) software modularization using community detection

    DEFF Research Database (Denmark)

    Hansen, Klaus Marius; Manikas, Konstantinos

    2015-01-01

    The modularity of a software system is known to have an effect on, among other, development effort, change impact, and technical debt. Modularizing a specific system and evaluating this modularization is, however, challenging. In this paper, we apply community detection methods to the graph...... of class dependencies in software systems to find optimal modularizations through communities. We evaluate this approach through a study of 111 Java systems contained in the Qualitas Corpus. We found that using the modularity function of Newman with an Erdős-Rényi null-model and using the community...... detection algorithm of Reichardt and Bornholdt improved community quality for all systems, that coupling decreased for 99 of the systems, and that coherence increased for 102 of the systems. Furthermore, the modularity function correlates with existing metrics for coupling and coherence....

  19. Modular inverter system

    Science.gov (United States)

    Ma, Mingyao; Hu, Haibing; Kutkut, Nasser; Batarseh, Issa; Shen, John; , Bkayrat, Raed

    2017-08-01

    A system connected to an AC power grid having an AC phase signal includes an inverter module including a first inverter coupled to a DC voltage, actuated based on the AC phase signal. The first inverter provides a first voltage signal having predetermined harmonic components. A second inverter includes second switch elements coupled to the DC voltage and actuated by a second set of control signals phase delayed with respect to the first control signals. A transformer module has first and second primary windings coupled to the first and second inverters. The transformer module further includes a secondary winding coupled to first primary winding, the second primary winding, and the AC power grid. The secondary winding is configured to provide a secondary output voltage to the AC power grid by combining the first voltage signal and the second voltage signal such that the predetermined harmonic components are substantially cancelled.

  20. The Usefulness of Clinical-Practice-Based Laboratory Data in Facilitating the Diagnosis of Dengue Illness

    Directory of Open Access Journals (Sweden)

    Jien-Wei Liu

    2013-01-01

    Full Text Available Alertness to dengue and making a timely diagnosis is extremely important in the treatment of dengue and containment of dengue epidemics. We evaluated the complementary role of clinical-practice-based laboratory data in facilitating suspicion/diagnosis of dengue. One hundred overall dengue (57 dengue fever [DF] and 43 dengue hemorrhagic fever [DHF] cases and another 100 nondengue cases (78 viral infections other than dengue, 6 bacterial sepsis, and 16 miscellaneous diseases were analyzed. We separately compared individual laboratory variables (platelet count [PC] , prothrombin time [PT], activated partial thromboplastin time [APTT], alanine aminotransferase [ALT], and aspartate aminotransferase [AST] and varied combined variables of DF and/or DHF cases with the corresponding ones of nondengue cases. The sensitivity, specificity, accuracy, positive predictive value (PPV, and negative predictive value (NPV in the diagnosis of DF and/or DHF were measured based on these laboratory variables. While trade-off between sensitivity and specificity, and/or suboptimal PPV/NPV was found at measurements using these variables, prolonged APTT + normal PT + PC < 100 × 109 cells/L had a favorable sensitivity, specificity, PPV, and NPV in diagnosis of DF and/or DHF. In conclusion, these data suggested that prolonged APTT + normal PT + PC < 100 × 109 cells/L is useful in evaluating the likelihood of DF and/or DHF.

  1. Residents' surgical performance during the laboratory years: an analysis of rule-based errors.

    Science.gov (United States)

    Nathwani, Jay N; Wise, Brett J; Garren, Margaret E; Mohamadipanah, Hossein; Van Beek, Nicole; DiMarco, Shannon M; Pugh, Carla M

    2017-11-01

    Nearly one-third of surgical residents will enter into academic development during their surgical residency by dedicating time to a research fellowship for 1-3 y. Major interest lies in understanding how laboratory residents' surgical skills are affected by minimal clinical exposure during academic development. A widely held concern is that the time away from clinical exposure results in surgical skills decay. This study examines the impact of the academic development years on residents' operative performance. We hypothesize that the use of repeated, annual assessments may result in learning even without individual feedback on participants simulated performance. Surgical performance data were collected from laboratory residents (postgraduate years 2-5) during the summers of 2014, 2015, and 2016. Residents had 15 min to complete a shortened, simulated laparoscopic ventral hernia repair procedure. Final hernia repair skins from all participants were scored using a previously validated checklist. An analysis of variance test compared the mean performance scores of repeat participants to those of first time participants. Twenty-seven (37% female) laboratory residents provided 2-year assessment data over the 3-year span of the study. Second time performance revealed improvement from a mean score of 14 (standard error = 1.0) in the first year to 17.2 (SD = 0.9) in the second year, (F[1, 52] = 5.6, P = 0.022). Detailed analysis demonstrated improvement in performance for 3 grading criteria that were considered to be rule-based errors. There was no improvement in operative strategy errors. Analysis of longitudinal performance of laboratory residents shows higher scores for repeat participants in the category of rule-based errors. These findings suggest that laboratory residents can learn from rule-based mistakes when provided with annual performance-based assessments. This benefit was not seen with operative strategy errors and has important implications for

  2. A portable modular optical sensor capable of measuring complex multi-axis strain fields

    Science.gov (United States)

    Zhao, Weixin; Beck, B. Terry; Peterman, Robert J.; Wu, Chih-Hang J.

    2012-10-01

    This paper presents a portable optical sensor capable of measuring complex multi-axis strain fields without the need for special surface preparation or stringent sensor-to-surface alignment. The sensor consists of three to four electronic speckle photography (ESP) modules. The design of each modular element is based on a previously developed 5-axis (five degree of freedom) surface displacement measurement technique, and is able to measure two dimensional in-plane surface movement, unaffected by other degrees of freedom (displacement and rotation) movement. Identical modular strain elements are arranged in a Rosette grid layout so that accurate and robust multi-axis surface strain measurement can be achieved. Experiments were conducted to demonstrate the multi-axis strain field measurement capability of this optical sensor by using a test bed that provided a known directional planar strain field, and excellent results were obtained. In particular, experiments have shown that the principle strain can be accurately extracted independent of the orientation of the device. This portable optical sensor will allow precise non-contact measurement of practical complex strain fields such as those encountered in bridge abutments, and portions of beams near critical infrastructure support locations; in other words, wherever plane strains depart from uni-axial behavior. Its unique hand-held portable capability offers distinct advantages over laboratory strain measurement setups, allowing accurate robust non-contact measurements to be achieved even in a harsh field application environment.

  3. A HUMAN AUTOMATION INTERACTION CONCEPT FOR A SMALL MODULAR REACTOR CONTROL ROOM

    Energy Technology Data Exchange (ETDEWEB)

    Le Blanc, Katya; Spielman, Zach; Hill, Rachael

    2017-06-01

    Many advanced nuclear power plant (NPP) designs incorporate higher degrees of automation than the existing fleet of NPPs. Automation is being introduced or proposed in NPPs through a wide variety of systems and technologies, such as advanced displays, computer-based procedures, advanced alarm systems, and computerized operator support systems. Additionally, many new reactor concepts, both full scale and small modular reactors, are proposing increased automation and reduced staffing as part of their concept of operations. However, research consistently finds that there is a fundamental tradeoff between system performance with increased automation and reduced human performance. There is a need to address the question of how to achieve high performance and efficiency of high levels of automation without degrading human performance. One example of a new NPP concept that will utilize greater degrees of automation is the SMR concept from NuScale Power. The NuScale Power design requires 12 modular units to be operated in one single control room, which leads to a need for higher degrees of automation in the control room. Idaho National Laboratory (INL) researchers and NuScale Power human factors and operations staff are working on a collaborative project to address the human performance challenges of increased automation and to determine the principles that lead to optimal performance in highly automated systems. This paper will describe this concept in detail and will describe an experimental test of the concept. The benefits and challenges of the approach will be discussed.

  4. A novel approach to achieving modular retrovirus clearance for a parvovirus filter.

    Science.gov (United States)

    Stuckey, Juliana; Strauss, Daniel; Venkiteshwaran, Adith; Gao, Jinxin; Luo, Wen; Quertinmont, Michelle; O'Donnell, Sean; Chen, Dayue

    2014-01-01

    Viral filtration is routinely incorporated into the downstream purification processes for the production of biologics produced in mammalian cell cultures (MCC) to remove potential viral contaminants. In recent years, the use of retentive filters designed for retaining parvovirus (~20 nm) has become an industry standard in a conscious effort to further improve product safety. Since retentive filters remove viruses primarily by the size exclusion mechanism, it is expected that filters designed for parvovirus removal can effectively clear larger viruses such as retroviruses (~100 nm). In an attempt to reduce the number of viral clearance studies, we have taken a novel approach to demonstrate the feasibility of claiming modular retrovirus clearance for Asahi Planova 20N filters. Porcine parvovirus (PPV) and xenotropic murine leukemia virus (XMuLV) were co-spiked into six different feedstreams and then subjected to laboratory scale Planova 20N filtration. Our results indicate that Planova 20N filters consistently retain retroviruses and no retrovirus has ever been detected in the filtrates even when significant PPV breakthrough is observed. Based on the data from multiple in-house viral validation studies and the results from the co-spiking experiments, we have successfully claimed a modular retrovirus clearance of greater than 6 log10 reduction factors (LRF) to support clinical trial applications in both USA and Europe. © 2013 American Institute of Chemical Engineers.

  5. A Modular Building Controls Virtual Test Bed for the Integrations of Heterogeneous Systems

    Energy Technology Data Exchange (ETDEWEB)

    Wetter, Michael; Wetter, Michael; Haves, Philip

    2008-06-30

    This paper describes the Building Controls Virtual Test Bed (BCVTB) that is currently under development at Lawrence Berkeley National Laboratory. An earlier prototype linked EnergyPlus with controls hardware through embedded SPARK models and demonstrated its value in more cost-effective envelope design and improved controls sequences for the San Francisco Federal Building. The BCVTB presented here is a more modular design based on a middleware that we built using Ptolemy II, a modular software environment for design and analysis of heterogeneous systems. Ptolemy II provides a graphical model building environment, synchronizes the exchanged data and visualizes the system evolution during run-time. Our additions to Ptolemy II allow users to couple to Ptolemy II a prototype version of EnergyPlus,MATLAB/Simulink or other simulation programs for data exchange during run-time. In future work we will also implement a BACnet interface that allows coupling BACnet compliant building automation systems to Ptolemy II. We will present the architecture of the BCVTB and explain how users can add their own simulation programs to the BCVTB. We will then present an example application in which the building envelope and the HVAC system was simulated in EnergyPlus, the supervisory control logic was simulated in MATLAB/Simulink and Ptolemy II was used to exchange data during run-time and to provide realtime visualization as the simulation progresses.

  6. Probabilistic Analysis of Passive Safety System Reliability in Advanced Small Modular Reactors: Methodologies and Lessons Learned

    Energy Technology Data Exchange (ETDEWEB)

    Grabaskas, David; Bucknor, Matthew; Brunett, Acacia; Grelle, Austin

    2015-06-28

    Many advanced small modular reactor designs rely on passive systems to fulfill safety functions during accident sequences. These systems depend heavily on boundary conditions to induce a motive force, meaning the system can fail to operate as intended due to deviations in boundary conditions, rather than as the result of physical failures. Furthermore, passive systems may operate in intermediate or degraded modes. These factors make passive system operation difficult to characterize with a traditional probabilistic framework that only recognizes discrete operating modes and does not allow for the explicit consideration of time-dependent boundary conditions. Argonne National Laboratory has been examining various methodologies for assessing passive system reliability within a probabilistic risk assessment for a station blackout event at an advanced small modular reactor. This paper describes the most promising options: mechanistic techniques, which share qualities with conventional probabilistic methods, and simulation-based techniques, which explicitly account for time-dependent processes. The primary intention of this paper is to describe the strengths and weaknesses of each methodology and highlight the lessons learned while applying the two techniques while providing high-level results. This includes the global benefits and deficiencies of the methods and practical problems encountered during the implementation of each technique.

  7. RSA and its Correctness through Modular Arithmetic

    Science.gov (United States)

    Meelu, Punita; Malik, Sitender

    2010-11-01

    To ensure the security to the applications of business, the business sectors use Public Key Cryptographic Systems (PKCS). An RSA system generally belongs to the category of PKCS for both encryption and authentication. This paper describes an introduction to RSA through encryption and decryption schemes, mathematical background which includes theorems to combine modular equations and correctness of RSA. In short, this paper explains some of the maths concepts that RSA is based on, and then provides a complete proof that RSA works correctly. We can proof the correctness of RSA through combined process of encryption and decryption based on the Chinese Remainder Theorem (CRT) and Euler theorem. However, there is no mathematical proof that RSA is secure, everyone takes that on trust!.

  8. Modular Regularization Algorithms

    DEFF Research Database (Denmark)

    Jacobsen, Michael

    2004-01-01

    The class of linear ill-posed problems is introduced along with a range of standard numerical tools and basic concepts from linear algebra, statistics and optimization. Known algorithms for solving linear inverse ill-posed problems are analyzed to determine how they can be decomposed into indepen......The class of linear ill-posed problems is introduced along with a range of standard numerical tools and basic concepts from linear algebra, statistics and optimization. Known algorithms for solving linear inverse ill-posed problems are analyzed to determine how they can be decomposed...... into independent modules. These modules are then combined to form new regularization algorithms with other properties than those we started out with. Several variations are tested using the Matlab toolbox MOORe Tools created in connection with this thesis. Object oriented programming techniques are explained...... and used to set up the illposed problems in the toolbox. Hereby, we are able to write regularization algorithms that automatically exploit structure in the ill-posed problem without being rewritten explicitly. We explain how to implement a stopping criteria for a parameter choice method based upon...

  9. Problems in the theory of modular forms

    CERN Document Server

    Murty, M Ram; Graves, Hester

    2016-01-01

    This book introduces the reader to the fascinating world of modular forms through a problem-solving approach. As such, besides researchers, the book can be used by the undergraduate and graduate students for self-instruction. The topics covered include q-series, the modular group, the upper half-plane, modular forms of level one and higher level, the Ramanujan τ-function, the Petersson inner product, Hecke operators, Dirichlet series attached to modular forms and further special topics. It can be viewed as a gentle introduction for a deeper study of the subject. Thus, it is ideal for non-experts seeking an entry into the field. .

  10. MODULAR CONSTRUCTION SYSTEM EVALUATION

    International Nuclear Information System (INIS)

    Gillespie, S.

    2002-01-01

    The purpose of this study is to respond to U.S. Department of Energy (DOE) Technical Direction Letter (TDL) 02-003 (Waisley 2001), which directs Bechtel SAIC Company, LLC (BSC) to complete a design study to recommend repository design options to support receipt and/or emplacement of any or all of the following: commercial spent nuclear fuel (CSNF), high-level radioactive waste (HLW), DOE-managed spent nuclear fuel (DSNF) (including naval spent nuclear fuel [SNF]), and immobilized plutonium (if available), as soon as practicable, but no later than 2010. From the possible design options, a recommended approach will be determined for further evaluation to support the preliminary design of the repository. This study integrates the results of the repository Design Evolution Study (Rowe 2002) with supporting studies concerning national transportation options (BSC 2002b) and Nevada transportation options (Gehner 2002). The repository Design Evolution Study documents the processes used to reevaluate the design, construction, operation, and cost of the repository in response to TDL 02-003 (Waisley 2001), and to determine possible repository conceptual design options. The transportation studies evaluate the national and Nevada transportation options that support the repository conceptual design options. An evaluation methodology was established, based on Program-level requirements developed for the study in reference BSC 2001a, to allow the repository and system design options to be evaluated on a consistent basis. The transportation options and the design components were integrated into system design implementation options, which were evaluated using receipt and emplacement scenarios. The scenarios tested the ability of the design concept to adapt to changes in funding, waste receipt rate, and Nevada rail transportation availability. The results of the evaluation (in terms of system throughput, cost, and schedule) were then compared to the Program-level requirements, and

  11. Guided-inquiry based laboratory instruction: Investigation of critical thinking skills, problem solving skills, and implementing student roles in chemistry

    Science.gov (United States)

    Gupta, Tanya

    Recent initiatives in the laboratory curriculum have encouraged an inquiry-based approach to learning and teaching in the laboratory. It has been argued that laboratory instruction should not just be hands-on, but it should portray the essence of inquiry through the process of experiential learning and reflective engagement in collaboration with peers and in facilitation by the instructor. A student-centered active learning approach may be an effective way to enhance student understanding of concepts in the laboratory. The dissertation research work explores the impact of laboratory instruction and its relevance for college-level chemistry. Each chapter is different from the preceding chapter in terms of the purpose of the study and the research questions asked. However, the overarching idea is to address the importance of guided-inquiry based laboratory instruction in chemistry and its relevance in helping students to make connections with the chemistry content and in imparting skills to students. Such skills include problem solving, collaborative group work and critical thinking. The first research study (Chapter 2) concerns the impact of first year co-requisite general chemistry laboratory instruction on the problem-solving skills of students. The second research study (Chapter 3) examines the impact of implementing student roles also known as Student-Led Instructor Facilitated Guided-Inquiry based Laboratories, SLIFGIL) by modifying the Science Writing Heuristic approach of laboratory instruction. In the third research study (Chapter 4), critical thinking skills of first semester general chemistry laboratory students were compared to advanced (third or fourth year) chemistry laboratory students based on the analysis of their laboratory reports.

  12. The modularity of pollination networks

    DEFF Research Database (Denmark)

    Olesen, Jens Mogens; Bascompte, J.; Dupont, Yoko

    2007-01-01

    consist of strongly connected species. The importance of modularity has been discussed for a long time, but no consensus on its prevalence in ecological networks has yet been reached. Progress is hampered by inadequate methods and a lack of large datasets. We analyzed 51 pollination networks including...... linked species within their own module), connectors linking different modules, or both. If these key species go extinct, modules and networks may break apart and initiate cascades of extinction. Thus, species serving as hubs and connectors should receive high conservation priorities.    ...

  13. CP violation and modular symmetries

    International Nuclear Information System (INIS)

    Dent, Thomas

    2001-01-01

    We reconsider the origin of CP violation in fundamental theory. Existing string models of spontaneous CP violation make ambiguous predictions, due to the arbitrariness of CP transformation and the apparent noninvariance of the results under duality. We find a modular CP invariance condition, applicable to any predictive model of spontaneous CP violation, which circumvents these problems; it strongly constrains CP violation by heterotic string moduli. The dilaton is also evaluated as a source of CP violation, but is likely experimentally excluded. We consider the prospects for explaining CP violation in strongly coupled strings and brane worlds

  14. Modular training for career counsellors

    Directory of Open Access Journals (Sweden)

    Maruša Goršak

    2015-12-01

    Full Text Available Exactly ten years have passed since first attempts were made in Slovenia to establish a comprehensive and formalized educational program for counsellors working in the field of lifelong career guidance. In the past, organizations providing (career guidance services have established their own non-formal employee trainings. A step forward has been made under the framework of the project “National coordination point for lifelong career guidance”, which enabled the implementation of the first joint training for (career guidance counsellors, called Modular training of career counsellors.

  15. Design of simulated nuclear electronics laboratory experiments based on IAEA-TECDOC-530 on pcs

    International Nuclear Information System (INIS)

    Ghousia, S.F.; Nadeem, M.; Khaleeq, M.T.

    2002-05-01

    In this IAEA project, PK-11089 (Design of Simulated Nuclear Electronics Laboratory Experiments based on IAEA-TECDOC-530 on PCs), a software package consisting of Computer-Simulated Laboratory Experiments on Nuclear Electronics compatible with the IAEA-TECDOC-530 (Nuclear Electronics Laboratory Manual) has been developed in OrCAD 9.0 (an electronic circuit simulation software environment) as a self-training aid. The software process model employed in this project is the Feedback Waterfall model with some Rapid Application Model. The project work is completed in the five phases of the SDLC, (all of them have been fully completed) which includes the Requirement Definition, Phase, System and Software Design, Implementation and Unit testing, Integration and System-testing phase and the Operation and Maintenance phase. A total of 125 circuits are designed in 39 experiments from Power Supplies, Analog circuits, Digital circuits and Multi-channel analyzer sections. There is another set of schematic designs present in the package, which contains faulty circuits. This set is designed for the learners to exercise the troubleshooting. The integration and system-testing phase was carried out simultaneously. The Operation and Maintenance phase has been implemented by accomplishing it through some trainees and some undergraduate engineering students by allowing them to play with the software independently. (author)

  16. Quantitative comparison of cranial approaches in the anatomy laboratory: A neuronavigation based research method.

    Science.gov (United States)

    Doglietto, Francesco; Qiu, Jimmy; Ravichandiran, Mayoorendra; Radovanovic, Ivan; Belotti, Francesco; Agur, Anne; Zadeh, Gelareh; Fontanella, Marco Maria; Kucharczyk, Walter; Gentili, Fred

    2017-12-26

    To describe the development and validation of a novel neuronavigation-based method, which allows the quantification of the anatomical features that define an approach, as well as real-time visualization of the surgical pyramid. The method was initially developed with commercially-available hardware for coordinate collection (a digitizer and a frameless navigation system) and software for volume rendering; dedicated neuronavigation software (ApproachViewer, part of GTx-UHN) was then developed. The accuracy of measurements and the possibility of volumetric rendering of surgical approaches simulated in a phantom were compared among three different methods and commercially-available radiological software. In the anatomy laboratory, ApproachViewer was applied to the comparative quantitative analysis of multiple neurosurgical approaches and was used by many surgeons who were untrained for the research method. The accuracy of ApproachViewer is comparable to commercially-available radiological software. In the anatomy laboratory, the method appears versatile. The system can be easily used after brief training. ApproachViewer allows for real-time evaluation and comparison of surgical approaches, as well as post-dissection analyses of collected data. The accuracy of the method depends on the navigation registration: with a 1-2 mm registration error, it is adequate for evaluation and comparison of most neurosurgical approaches. This new research method and software allows semi-automated visualization, quantification, and comparison of neurosurgical approaches in the anatomy laboratory.

  17. Comparing the Impact of Course-Based and Apprentice-Based Research Experiences in a Life Science Laboratory Curriculum

    Directory of Open Access Journals (Sweden)

    Casey Shapiro

    2015-10-01

    Full Text Available This four-year study describes the assessment of a bifurcated laboratory curriculum designed to provide upper-division undergraduate majors in two life science departments meaningful exposure to authentic research. The timing is critical as it provides a pathway for both directly admitted and transfer students to enter research. To fulfill their degree requirements, all majors complete one of two paths in the laboratory program. One path immerses students in scientific discovery experienced through team research projects (course-based undergraduate research experiences, or CUREs and the other path through a mentored, independent research project (apprentice-based research experiences, or AREs. The bifurcated laboratory curriculum was structured using backwards design to help all students, irrespective of path, achieve specific learning outcomes. Over 1,000 undergraduates enrolled in the curriculum. Self-report survey results indicate that there were no significant differences in affective gains by path. Students conveyed which aspects of the curriculum were critical to their learning and development of research-oriented skills. Students’ interests in biology increased upon completion of the curriculum, inspiring a subset of CURE participants to subsequently pursue further research. A rubric-guided performance evaluation, employed to directly measure learning, revealed differences in learning gains for CURE versus ARE participants, with evidence suggesting a CURE can reduce the achievement gap between high-performing students and their peers.

  18. Contribution of emissions to concentrations: the TAGGING 1.0 submodel based on the Modular Earth Submodel System (MESSy 2.52)

    Science.gov (United States)

    Grewe, Volker; Tsati, Eleni; Mertens, Mariano; Frömming, Christine; Jöckel, Patrick

    2017-07-01

    Questions such as what is the contribution of road traffic emissions to climate change? or what is the impact of shipping emissions on local air quality? require a quantification of the contribution of specific emissions sectors to the concentration of radiatively active species and air-quality-related species, respectively. Here, we present a diagnostics package, implemented in the Modular Earth Submodel System (MESSy), which keeps track of the contribution of source categories (mainly emission sectors) to various concentrations. The diagnostics package is implemented as a submodel (TAGGING) of EMAC (European Centre for Medium-Range Weather Forecasts - Hamburg (ECHAM)/MESSy Atmospheric Chemistry). It determines the contributions of 10 different source categories to the concentration of ozone, nitrogen oxides, peroxyacytyl nitrate, carbon monoxide, non-methane hydrocarbons, hydroxyl, and hydroperoxyl radicals ( = tagged tracers). The source categories are mainly emission sectors and some other sources for completeness. As emission sectors, road traffic, shipping, air traffic, anthropogenic non-traffic, biogenic, biomass burning, and lightning are considered. The submodel obtains information on the chemical reaction rates, online emissions, such as lightning, and wash-out rates. It then solves differential equations for the contribution of a source category to each of the seven tracers. This diagnostics package does not feed back to any other part of the model. For the first time, it takes into account chemically competing effects: for example, the competition between NOx, CO, and non-methane hydrocarbons (NMHCs) in the production and destruction of ozone. We show that the results are in-line with results from other tagging schemes and provide plausibility checks for concentrations of trace gases, such as OH and HO2, which have not previously been tagged. The budgets of the tagged tracers, i.e. the contribution from individual source categories (mainly emission

  19. A CCD-based area detector for X-ray crystallography using synchrotron and laboratory sources

    International Nuclear Information System (INIS)

    Phillips, W.C.; Li Youli; Stanton, M.; Xie Yuanhui; O'Mara, D.; Kalata, K.

    1993-01-01

    The design and characteristics of a CCD-based area detector suitable for X-ray crystallographic studies using both synchrotron and laboratory sources are described. The active area is 75 mm in diameter, the FWHM of the point response function is 0.20 mm, and for Bragg peaks the dynamic range is 900 and the DQE ∼0.3. The 1320x1035-pixel Kodak CCD is read out into an 8 Mbyte memory system in 0.14 s and digitized to 12 bits. X-ray crystallographic data collected at the NSLS synchrotron from cubic insulin crystals are presented. (orig.)

  20. 2018 Annual Terrestrial Sampling Plan for Sandia National Laboratories/New Mexico on Kirtland Air Force Base.

    Energy Technology Data Exchange (ETDEWEB)

    Griffith, Stacy R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2018-01-01

    The 2018 Annual Terrestrial Sampling Plan for Sandia National Laboratories/New Mexico on Kirtland Air Force Base has been prepared in accordance with the “Letter of Agreement Between Department of Energy, National Nuclear Security Administration, Sandia Field Office (DOE/NNSA/SFO) and 377th Air Base Wing (ABW), Kirtland Air Force Base (KAFB) for Terrestrial Sampling” (signed January 2017), Sandia National Laboratories, New Mexico (SNL/NM). The Letter of Agreement requires submittal of an annual terrestrial sampling plan.

  1. 2017 Annual Terrestrial Sampling Plan for Sandia National Laboratories/New Mexico on Kirtland Air Force Base

    Energy Technology Data Exchange (ETDEWEB)

    Griffith, Stacy R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-02-01

    The 2017 Annual Terrestrial Sampling Plan for Sandia National Laboratories/New Mexico on Kirtland Air Force Base has been prepared in accordance with the “Letter of Agreement Between Department of Energy, National Nuclear Security Administration, Sandia Field Office (DOE/NNSA/SFO) and 377th Air Base Wing (ABW), Kirtland Air Force Base (KAFB) for Terrestrial Sampling” (signed January 2017), Sandia National Laboratories, New Mexico (SNL/NM). The Letter of Agreement requires submittal of an annual terrestrial sampling plan.

  2. Development of a Wiimote-based Gesture Recognizer in a Microprocessor Laboratory Course

    Directory of Open Access Journals (Sweden)

    Alberto Lorente Leal

    2011-03-01

    Full Text Available This gesture recognizer, developed by students in a third-year microprocessor-based laboratory course, takes Wii remote (Wiimote as an input device to estimate the movements of the user and to compare the detected trajectory with the previously learnt movements, in order to carry out the associated actions. Such a cheap state-of-the-art wireless user interface is very attractive for the students and can be used in many interactive applications, from robotics to virtual reality and multimedia presentations. By combining commercially-available hardware, pattern-matching techniques and programming skills, we are able to foster students' interest on developing innovative potentially-marketable systems. This freeware project, implemented as a configurable publicly-available library, can be adapted to the needs of any course or student. In our laboratory this open-source DLL is used for remotely controlling a robot (based on an open-hardware Arduino platform, using a PC and the Wiimote, although the DLL can be integrated in any C, C++, Java or C# project. A GUI application (based on a Model-View-Presenter paradigm is also provided and can be used as a template for new applications or just for debugging purposes. Although the developed application only uses data from the accelerometers, data from the infrared camera and buttons of the Wiimote is also available.

  3. Integration of laboratory bioassays into the risk-based corrective action process

    International Nuclear Information System (INIS)

    Edwards, D.; Messina, F.; Clark, J.

    1995-01-01

    Recent data generated by the Gas Research Institute (GRI) and others indicate that residual hydrocarbon may be bound/sequestered in soil such that it is unavailable for microbial degradation, and thus possibly not bioavailable to human/ecological receptors. A reduction in bioavailability would directly equate to reduced exposure and, therefore, potentially less-conservative risk-based cleanup soil goals. Laboratory bioassays which measure bioavailability/toxicity can be cost-effectively integrated into the risk-based corrective action process. However, in order to maximize the cost-effective application of bioassays several site-specific parameters should be addressed up front. This paper discusses (1) the evaluation of parameters impacting the application of bioassays to soils contaminated with metals and/or petroleum hydrocarbons and (2) the cost-effective integration of bioassays into a tiered ASTM type framework for risk-based corrective action

  4. The problem-based learning tutorial laboratory - a method for training medical teachers.

    Science.gov (United States)

    Vanhanen, Hannu; Pitkälä, Kaisu; Puolakkainen, Pauli; Strandberg, Timo E.; Lonka, Kirsti

    2001-01-01

    An extensive staff development program was started in 1998 in the Faculty of Medicine at the University of Helsinki. A problem-based learning method was introduced as a new style of teaching in the curriculum reform. This paper describes a teaching method 'Problem-based learning - tutorial laboratory' for training medical teachers to act as tutors and to understand their roles as facilitators of learning and the dynamics of a small group. The method was based on learning cycles: teachers had a possibility to experience tutoring, to get feedback about it from an educational expert and from a peer teacher and also they were able to reflect on their views in the group. The teachers were content with the training. Sessions improved teacher cooperation across the departments and brought new teaching ideas for shared use. It also helped to cope with the resistance related to the curriculum change process.

  5. Students Using a Novel Web-Based Laboratory Class Support System: A Case Study in Food Chemistry Education

    Science.gov (United States)

    van der Kolk, Koos; Beldman, Gerrit; Hartog, Rob; Gruppen, Harry

    2012-01-01

    The design, usage, and evaluation of a Web-based laboratory manual (WebLM) are described. The main aim of the WebLM is to support students while working in the laboratory by providing them with just-in-time information. Design guidelines for this electronic manual were derived from literature on cognitive load and user interface design. The WebLM…

  6. Students Using a Novel Web-Based Laboratory Class Support System: A Case Study in Food Chemistry Education

    NARCIS (Netherlands)

    Kolk, van der J.; Beldman, G.; Hartog, R.; Gruppen, H.

    2012-01-01

    The design, usage, and evaluation of a Web-based laboratory manual (WebLM) are described. The main aim of the WebLM is to support students while working in the laboratory by providing them with just-in-time information. Design guidelines for this electronic manual were derived from literature on

  7. The Efficacy of Problem-Based Learning in an Analytical Laboratory Course for Pre-Service Chemistry Teachers

    Science.gov (United States)

    Yoon, Heojeong; Woo, Ae Ja; Treagust, David; Chandrasegaran, A. L.

    2014-01-01

    The efficacy of problem-based learning (PBL) in an analytical chemistry laboratory course was studied using a programme that was designed and implemented with 20 students in a treatment group over 10 weeks. Data from 26 students in a traditional analytical chemistry laboratory course were used for comparison. Differences in the creative thinking…

  8. Upcycling UAS into modular platforms for Earth science and autonomy research

    Science.gov (United States)

    Dahlgren, R. P.; Dary, O. G.; Ogunbiyi, J. A.; Pinsker, E. A.; Reynolds, K. W.; Werner, C. A.

    2015-12-01

    This reports the results of a multidisciplinary project conducted at the NASA Ames Research Center (ARC) involving a number of student interns over the summers of 2014 and 2015. The project had a goal of applying rapid prototyping techniques, including 3D printing, to unmanned aircraft systems (UAS), and demonstrated that surplus UAS could be repurposed into new configurations suitable for conducting science missions. ARC received several units of the RQ-11 Raven and RQ-14 DragonEye manufactured by AeroVironment Corporation, along with ground stations and spare parts. These UAS have electric propulsion, a wingspan and length ~1m; they are designed to disassemble for transport, have a simple wing design with snap-together interfaces, made from lightweight materials. After removing all ITAR restricted technology these were made available to summer interns that also had access to 3D printing, CNC laser-cutting equipment through NASA's SpaceShop. The modular nature and simple wing profiles enabled the teams to deconstruct and subsequently reconfigure them into completely new airframes. Two multi-fuselage designs were assembled using Ardupilot-based common avionics architecture (CAA), with extended wingspans, an H-tail and an innovative cambered flap system. After NASA internal design reviews, the students fabricated new control surfaces and subcomponents necessary to splice the RQ-14 subcomponents back together. Laboratory testing was performed on test articles to determine bending modulus and safety factors, and documentation was prepared for airworthiness flight safety review. Upon receiving approval of documentation and flight readiness certification, the repurposed UAS were flown at Crows Landing airfield in Stanislaus County, California, initially under RC pilot control and subsequently under fully autonomous control. The RQ-11 is now being used to expand on the modularity design and the Team has been at work in designing different configurations and a payload pod

  9. Kahler stabilized, modular invariant heterotic string models

    Energy Technology Data Exchange (ETDEWEB)

    Gaillard, Mary K.; Gaillard, Mary K.; Nelson, Brent D.

    2007-03-19

    We review the theory and phenomenology of effective supergravity theories based on orbifold compactifications of the weakly-coupled heterotic string. In particular, we consider theories in which the four-dimensional theory displays target space modular invariance and where the dilatonic mode undergoes Kahler stabilization. A self-contained exposition of effective Lagrangian approaches to gaugino condensation and heterotic string theory is presented, leading to the development of the models of Binétruy, Gaillard and Wu. Various aspects of the phenomenology of this class of models are considered. These include issues of supersymmetry breaking and superpartner spectra, the role of anomalous U(1) factors, issues of flavor and R-parity conservation, collider signatures, axion physics, and early universe cosmology. For the vast majority of phenomenological considerations the theories reviewed here compare quite favorably to other string-derived models in the literature. Theoretical objections to the framework and directions for further research are identified and discussed.

  10. Modular Chemical Descriptor Language (MCDL: Stereochemical modules

    Directory of Open Access Journals (Sweden)

    Gakh Andrei A

    2011-01-01

    Full Text Available Abstract Background In our previous papers we introduced the Modular Chemical Descriptor Language (MCDL for providing a linear representation of chemical information. A subsequent development was the MCDL Java Chemical Structure Editor which is capable of drawing chemical structures from linear representations and generating MCDL descriptors from structures. Results In this paper we present MCDL modules and accompanying software that incorporate unique representation of molecular stereochemistry based on Cahn-Ingold-Prelog and Fischer ideas in constructing stereoisomer descriptors. The paper also contains additional discussions regarding canonical representation of stereochemical isomers, and brief algorithm descriptions of the open source LINDES, Java applet, and Open Babel MCDL processing module software packages. Conclusions Testing of the upgraded MCDL Java Chemical Structure Editor on compounds taken from several large and diverse chemical databases demonstrated satisfactory performance for storage and processing of stereochemical information in MCDL format.

  11. Modular Stellarator Fusion Reactor (MSR) concept

    International Nuclear Information System (INIS)

    Miller, R.L.; Krakowski, R.A.

    1981-01-01

    A preliminary conceptual study has been made of the Modulator Stellarator Reactor (MSR) as a stedy-state, ignited, DT-fueled, magnetic fusion reactor. The MSR concept combines the physics of classic stellarator confinement with an innovative, modular-coil design. Parametric tradeoff calculations are described, leading to the selection of an interim design point for a 4.8-GWt plant based on Alcator transport scaling and an average beta value of 0.04 in an l = 2 system with a plasma aspect ratio of 11. Neither an economic analysis nor a detailed conceptual engineering design is presented here, as the primary intent of this scoping study is the elucidation of key physics tradeoffs, constraints, and uncertainties for the ultimate power-reactor embodiment

  12. Jargon and Graph Modularity on Twitter

    Energy Technology Data Exchange (ETDEWEB)

    Dowling, Chase P.; Corley, Courtney D.; Farber, Robert M.; Reynolds, William

    2013-09-01

    The language of conversation is just as dependent upon word choice as it is on who is taking part. Twitter provides an excellent test-bed in which to conduct experiments not only on language usage but on who is using what language with whom. To this end, we combine large scale graph analytical techniques with known socio-linguistic methods. In this article we leverage both expert curated vocabularies and naive mathematical graph analyses to determine if network behavior on Twitter corroborates with the current understanding of language usage. The results reported indicate that, based on networks constructed from user to user communication and communities identified using the Clauset- Newman greedy modularity algorithm we find that more prolific users of these curated vocabularies are concentrated in distinct network communities.

  13. Modular manual control device for manipulators

    International Nuclear Information System (INIS)

    Dzholdasbekov, U.A.; Lukyanov, A.T.; Slutsky, L.I.; Safontsev, E.A.; Dzhamalov, N.K.

    1991-01-01

    The device described in this patent comprises a base, a series of connected modules, each with a position pickup and a handle. One module is provided for each degree of mobility of the manipulator being controlled; the modular construction enables the control of manipulators with differing degrees of mobility. One rotary movement module and three orthogonal linear movement modules are provided. Each linear module has two parallel guides between which a carriage is supported for movement by balls. The position pickup is provided on the carriage. The rotary module comprises inner and outer casings, relative movement of which is detected by pickup. Further rotary pickups may be provided for rotation about axes. A close/open switch and a speed control pickup may also be provided. (author)

  14. Morphology Independent Learning in Modular Robots

    DEFF Research Database (Denmark)

    Christensen, David Johan; Bordignon, Mirko; Schultz, Ulrik Pagh

    2009-01-01

    Hand-coding locomotion controllers for modular robots is dif?cult due to their polymorphic nature. Instead, we propose to use a simple and distributed reinforcement learning strategy. ATRON modules with identical controllers can be assembled in any con?guration. To optimize the robot?s locomotion...... speed its modules independently and in parallel adjust their behavior based on a single global reward signal. In simulation, we study the learning strategy?s performance on different robot con?gurations. On the physical platform, we perform learning experiments with ATRON robots learning to move as fast...... as possible. We conclude that the learning strategy is effective and may be a practical approach to design gaits....

  15. Modular Interpreters for the Masses: Implicit Context Propagation using Object Algebras

    NARCIS (Netherlands)

    P.A. Inostroza Valdera (Pablo); T. van der Storm (Tijs); C. Kästner (Christian); A. Gokhālé (Aniruddha)

    2015-01-01

    htmlabstractModular interpreters have the potential to achieve component-based language development: instead of writing language interpreters from scratch, they can be assembled from reusable, semantic building blocks. Unfortunately, traditional language interpreters are hard to extend because

  16. Breaching the Phalanx: Developing a More Engineer-Centric Modular BCT

    National Research Council Canada - National Science Library

    Schultze, James M

    2007-01-01

    ... to OIF and OEF for SSTR operations. These new modular combat units are based on predominantly infantry and armor capabilities and have resulted in a large divestiture of engineering units and capabilities...

  17. Modular PM Motor Drives for Automotive Traction Applications

    International Nuclear Information System (INIS)

    Su, G.J.

    2001-01-01

    This paper presents modular permanent magnet (PM) motor drives for automotive traction applications. A partially modularized drive system consisting of a single PM motor and multiple inverters is described. The motor has multiple three-phase stator winding sets and each winding set is driven with a separate three-phase inverter module. A truly modularized inverter and motor configuration based on an axial-gap PM motor is then introduced, in which identical PM motor modules are mounted on a common shaft and each motor module is powered by a separate inverter module. The advantages of the modular approach for both inverter and motor include: (1) power rating scalability-one design meets different power requirements by simply stacking an adequate number of modules, thus avoiding redesigning and reducing the development cost, (2) increased fault tolerance, and (3) easy repairing. A prototype was constructed by using two inverters and an axial-gap PM motor with two sets of three-phase stat or windings, and it is used to assist the diesel engine in a hybrid electric vehicle converted from a Chevrolet Suburban. The effect of different pulse-width-modulation strategies for both motoring and regenerative modes on current control is analyzed. Torque and regenerative control algorithms are implemented with a digital signal processor. Analytical and initial testing results are included in the paper

  18. Lessons in modularity: the evolutionary ecology of colonial invertebrates

    Directory of Open Access Journals (Sweden)

    Roger N. Hughes

    2005-06-01

    Full Text Available Benthic colonial invertebrates share with higher plants a modular construction and a sessile adult life. Both types of organism show parallel evolutionary responses to common selective forces, but in contrast to the long-established focus on plants, comparable study of colonial invertebrates has developed relatively recently, largely owing to the application of new techniques in image processing and molecular biology. Species whose life cycles are readily completed under laboratory conditions and whose colonies are easily propagated from cuttings provide powerful models for experimentally investigating fundamental evolutionary problems, including metabolic allometry, the manifestation of ageing and the origin of allorecognition systems. Free of the confounding influences of behavioural manipulation and costs of copulation, colonial invertebrates whose water-borne sperm fertilize retained eggs lend themselves well to the experimental study of cryptic female choice, sperm competition and sexual conflict. In these respects, it will be productive to adopt and extend theoretical frameworks developed for flowering plants to guide experimental investigation of modular animals. Since mate choice occurs at the cellular level in modular animals, reproductive isolation is uncorrelated with morphology and cryptic speciation is likely to be widespread.

  19. Theta function identities associated with Ramanujan's modular ...

    Indian Academy of Sciences (India)

    Abstract. We present alternative proofs of some of Ramanujan's theta function identities associated with the modular equations of composite degree 15. Along the way we also find some new theta-function identities. We also give simple proofs of his modular equations of degree 15.

  20. Analytic properties of the Virasoro modular kernel

    Energy Technology Data Exchange (ETDEWEB)

    Nemkov, Nikita [Moscow Institute of Physics and Technology (MIPT), Dolgoprudny (Russian Federation); Institute for Theoretical and Experimental Physics (ITEP), Moscow (Russian Federation); National University of Science and Technology MISIS, The Laboratory of Superconducting metamaterials, Moscow (Russian Federation)

    2017-06-15

    On the space of generic conformal blocks the modular transformation of the underlying surface is realized as a linear integral transformation. We show that the analytic properties of conformal block implied by Zamolodchikov's formula are shared by the kernel of the modular transformation and illustrate this by explicit computation in the case of the one-point toric conformal block. (orig.)