WorldWideScience

Sample records for based energy scores

  1. Scoring Function Based on Weighted Residue Network

    Directory of Open Access Journals (Sweden)

    Shan Chang

    2011-12-01

    Full Text Available Molecular docking is an important method for the research of protein-protein interaction and recognition. A protein can be considered as a network when the residues are treated as its nodes. With the contact energy between residues as link weight, a weighted residue network is constructed in this paper. Two weighted parameters (strength and weighted average nearest neighbors’ degree are introduced into this model at the same time. The stability of a protein is characterized by its strength. The global topological properties of the protein-protein complex are reflected by the weighted average nearest neighbors’ degree. Based on this weighted network model and these two parameters, a new docking scoring function is proposed in this paper. The scoring and ranking for 42 systems’ bound and unbounded docking results are performed with this new scoring function. Comparing the results obtained from this new scoring function with that from the pair potentials scoring function, we found that this new scoring function has a similar performance to the pair potentials on some items, and this new scoring function can get a better success rate. The calculation of this new scoring function is easy, and the result of its scoring and ranking is acceptable. This work can help us better understand the mechanisms of protein-protein interactions and recognition.

  2. KiDoQ: using docking based energy scores to develop ligand based model for predicting antibacterials

    Directory of Open Access Journals (Sweden)

    Tewari Rupinder

    2010-03-01

    Full Text Available Abstract Background Identification of novel drug targets and their inhibitors is a major challenge in the field of drug designing and development. Diaminopimelic acid (DAP pathway is a unique lysine biosynthetic pathway present in bacteria, however absent in mammals. This pathway is vital for bacteria due to its critical role in cell wall biosynthesis. One of the essential enzymes of this pathway is dihydrodipicolinate synthase (DHDPS, considered to be crucial for the bacterial survival. In view of its importance, the development and prediction of potent inhibitors against DHDPS may be valuable to design effective drugs against bacteria, in general. Results This paper describes a methodology for predicting novel/potent inhibitors against DHDPS. Here, quantitative structure activity relationship (QSAR models were trained and tested on experimentally verified 23 enzyme's inhibitors having inhibitory value (Ki in the range of 0.005-22(mM. These inhibitors were docked at the active site of DHDPS (1YXD using AutoDock software, which resulted in 11 energy-based descriptors. For QSAR modeling, Multiple Linear Regression (MLR model was engendered using best four energy-based descriptors yielding correlation values R/q2 of 0.82/0.67 and MAE of 2.43. Additionally, Support Vector Machine (SVM based model was developed with three crucial descriptors selected using F-stepping remove-one approach, which enhanced the performance by attaining R/q2 values of 0.93/0.80 and MAE of 1.89. To validate the performance of QSAR models, external cross-validation procedure was adopted which accomplished high training/testing correlation values (q2/r2 in the range of 0.78-0.83/0.93-0.95. Conclusions Our results suggests that ligand-receptor binding interactions for DHDPS employing QSAR modeling seems to be a promising approach for prediction of antibacterial agents. To serve the experimentalist to develop novel/potent inhibitors, a webserver "KiDoQ" has been developed http

  3. Vinardo: A Scoring Function Based on Autodock Vina Improves Scoring, Docking, and Virtual Screening

    Science.gov (United States)

    Villarreal, Marcos A.

    2016-01-01

    Autodock Vina is a very popular, and highly cited, open source docking program. Here we present a scoring function which we call Vinardo (Vina RaDii Optimized). Vinardo is based on Vina, and was trained through a novel approach, on state of the art datasets. We show that the traditional approach to train empirical scoring functions, using linear regression to optimize the correlation of predicted and experimental binding affinities, does not result in a function with optimal docking capabilities. On the other hand, a combination of scoring, minimization, and re-docking on carefully curated training datasets allowed us to develop a simplified scoring function with optimum docking performance. This article provides an overview of the development of the Vinardo scoring function, highlights its differences with Vina, and compares the performance of the two scoring functions in scoring, docking and virtual screening applications. Vinardo outperforms Vina in all tests performed, for all datasets analyzed. The Vinardo scoring function is available as an option within Smina, a fork of Vina, which is freely available under the GNU Public License v2.0 from http://smina.sf.net. Precompiled binaries, source code, documentation and a tutorial for using Smina to run the Vinardo scoring function are available at the same address. PMID:27171006

  4. Credit Scoring Problem Based on Regression Analysis

    OpenAIRE

    Khassawneh, Bashar Suhil Jad Allah

    2014-01-01

    ABSTRACT: This thesis provides an explanatory introduction to the regression models of data mining and contains basic definitions of key terms in the linear, multiple and logistic regression models. Meanwhile, the aim of this study is to illustrate fitting models for the credit scoring problem using simple linear, multiple linear and logistic regression models and also to analyze the found model functions by statistical tools. Keywords: Data mining, linear regression, logistic regression....

  5. A Score Based Approach to Wild Bootstrap Inference

    OpenAIRE

    Patrick M. Kline; Andres Santos

    2010-01-01

    We propose a generalization of the wild bootstrap of Wu (1986) and Liu (1988) based upon perturbing the scores of M-estimators. This "score bootstrap" procedure avoids recomputing the estimator in each bootstrap iteration, making it substantially less costly to compute than the conventional nonparametric bootstrap, particularly in complex nonlinear models. Despite this computational advantage, in the linear model, the score bootstrap studentized test statistic is equivalent to that of the con...

  6. CREDIT SCORING MODELS WITH AUC MAXIMIZATION BASED ON WEIGHTED SVM

    OpenAIRE

    LIGANG ZHOU; KIN KEUNG LAI; JEROME YEN

    2009-01-01

    Credit scoring models are very important tools for financial institutions to make credit granting decisions. In the last few decades, many quantitative methods have been used for the development of credit scoring models with focus on maximizing classification accuracy. This paper proposes the credit scoring models with the area under receiver operating characteristics curve (AUC) maximization based on the new emerged support vector machines (SVM) techniques. Three main SVM models with differe...

  7. Association between value-based purchasing score and hospital characteristics

    Directory of Open Access Journals (Sweden)

    Borah Bijan J

    2012-12-01

    Full Text Available Abstract Background Medicare hospital Value-based purchasing (VBP program that links Medicare payments to quality of care will become effective from 2013. It is unclear whether specific hospital characteristics are associated with a hospital’s VBP score, and consequently incentive payments. The objective of the study was to assess the association of hospital characteristics with (i the mean VBP score, and (ii specific percentiles of the VBP score distribution. The secondary objective was to quantify the associations of hospital characteristics with the VBP score components: clinical process of care (CPC score and patient satisfaction score. Methods Observational analysis that used data from three sources: Medicare Hospital Compare Database, American Hospital Association 2010 Annual Survey and Medicare Impact File. The final study sample included 2,491 U.S. acute care hospitals eligible for the VBP program. The association of hospital characteristics with the mean VBP score and specific VBP score percentiles were assessed by ordinary least square (OLS regression and quantile regression (QR, respectively. Results VBP score had substantial variations, with mean score of 30 and 60 in the first and fourth quartiles of the VBP score distribution. For-profit status (vs. non-profit, smaller bed size (vs. 100–199 beds, East South Central region (vs. New England region and the report of specific CPC measures (discharge instructions, timely provision of antibiotics and beta blockers, and serum glucose controls in cardiac surgery patients were positively associated with mean VBP scores (p Conclusions Although hospitals serving the poor and the elderly are more likely to score lower under the VBP program, the correlation appears small. Profit status, geographic regions, number and type of CPC measures reported explain the most variation among scores.

  8. Dual-energy X-ray absorptiometry diagnostic discordance between Z-scores and T-scores in young adults.

    LENUS (Irish Health Repository)

    Carey, John J

    2009-01-01

    Diagnostic criteria for postmenopausal osteoporosis using central dual-energy X-ray absorptiometry (DXA) T-scores have been widely accepted. The validity of these criteria for other populations, including premenopausal women and young men, has not been established. The International Society for Clinical Densitometry (ISCD) recommends using DXA Z-scores, not T-scores, for diagnosis in premenopausal women and men aged 20-49 yr, though studies supporting this position have not been published. We examined diagnostic agreement between DXA-generated T-scores and Z-scores in a cohort of men and women aged 20-49 yr, using 1994 World Health Organization and 2005 ISCD DXA criteria. Four thousand two hundred and seventy-five unique subjects were available for analysis. The agreement between DXA T-scores and Z-scores was moderate (Cohen\\'s kappa: 0.53-0.75). The use of Z-scores resulted in significantly fewer (McNemar\\'s p<0.001) subjects diagnosed with "osteopenia," "low bone mass for age," or "osteoporosis." Thirty-nine percent of Hologic (Hologic, Inc., Bedford, MA) subjects and 30% of Lunar (GE Lunar, GE Madison, WI) subjects diagnosed with "osteoporosis" by T-score were reclassified as either "normal" or "osteopenia" when their Z-score was used. Substitution of DXA Z-scores for T-scores results in significant diagnostic disagreement and significantly fewer persons being diagnosed with low bone mineral density.

  9. Supporting the Co-operative Organisation of Rational Energy Use (SCORE). Romania Country Document

    International Nuclear Information System (INIS)

    Energy efficiency improvements in the various end-use sectors constitute a very substantial saving potential, which presently is insufficiently addressed in Central and Eastern Europe. For that reason the SCORE concept has been initiated. SCORE stands for 'Supporting the Cooperative Organisation of Rational Energy Use'. SCORE is a Netherlands society to society programme, aiming at assisting the social transformation in the Central and Eastern European countries through projects and actions aiming at improvements in environmental protection and energy end-use sectors. SCORE is managed by the Netherlands Agency for Energy and the Environment (Novem) in partnership with local agencies in Central and Eastern Europe. The SCORE Country Document is based on: Survey on the existing policies and measures for energy efficiency, identified barriers, and the priorities for energy efficiency improvement in the country. The survey was carried out among some of the most important actors in this area by interviews, supported by filling in a questionnaire in a common format. Review of the existing strategic and regulatory documents and policy papers, different information sources like studies, reports, Internet sites. In chapter 2 the qualitative and quantitative situation in the field of energy supply and consumption is presented. In chapter 3 several topics will be addressed to provide insight into the national energy efficiency and climate change policy, a review, of the actors, with their tasks and responsibilities, the domestic programmes and initiatives as well as the foreign assistance programmes and initiatives. Chapter 4 includes the bottlenecks and problems identified to improve the energy efficiency situation in Romania. In chapter 5 some remarks are made on the criteria for SCORE projects

  10. Engineering Student Self-Assessment through Confidence-Based Scoring

    Science.gov (United States)

    Yuen-Reed, Gigi; Reed, Kyle B.

    2015-01-01

    A vital aspect of an answer is the confidence that goes along with it. Misstating the level of confidence one has in the answer can have devastating outcomes. However, confidence assessment is rarely emphasized during typical engineering education. The confidence-based scoring method described in this study encourages students to both think about…

  11. Calcium scoring with dual-energy CT in men and women: an anthropomorphic phantom study

    Science.gov (United States)

    Li, Qin; Liu, Songtao; Myers, Kyle; Gavrielides, Marios A.; Zeng, Rongping; Sahiner, Berkman; Petrick, Nicholas

    2016-03-01

    This work aimed to quantify and compare the potential impact of gender differences on coronary artery calcium scoring with dual-energy CT. An anthropomorphic thorax phantom with four synthetic heart vessels (diameter 3-4.5 mm: female/male left main and left circumflex artery) were scanned with and without female breast plates. Ten repeat scans were acquired in both single- and dual-energy modes and reconstructed at six reconstruction settings: two slice thicknesses (3 mm, 0.6 mm) and three reconstruction algorithms (FBP, IR3, IR5). Agatston and calcium volume scores were estimated from the reconstructed data using a segmentation-based approach. Total calcium score (summation of four vessels), and male/female calcium scores (summation of male/female vessels scanned in phantom without/with breast plates) were calculated accordingly. Both Agatston and calcium volume scores were found comparable between single- and dual-energy scans (Pearson r= 0.99, pimaging protocols for improved gender-specific calcium scoring.

  12. Improving Iris Recognition Accuracy By Score Based Fusion Method

    CERN Document Server

    Gawande, Ujwalla; Kapur, Avichal

    2010-01-01

    Iris recognition technology, used to identify individuals by photographing the iris of their eye, has become popular in security applications because of its ease of use, accuracy, and safety in controlling access to high-security areas. Fusion of multiple algorithms for biometric verification performance improvement has received considerable attention. The proposed method combines the zero-crossing 1 D wavelet Euler number, and genetic algorithm based for feature extraction. The output from these three algorithms is normalized and their score are fused to decide whether the user is genuine or imposter. This new strategies is discussed in this paper, in order to compute a multimodal combined score.

  13. Opportunistic splitting for scheduling using a score-based approach

    KAUST Repository

    Rashid, Faraan

    2012-06-01

    We consider the problem of scheduling a user in a multi-user wireless environment in a distributed manner. The opportunistic splitting algorithm is applied to find the best group of users without reporting the channel state information to the centralized scheduler. The users find the best among themselves while requiring just a ternary feedback from the common receiver at the end of each mini-slot. The original splitting algorithm is modified to handle users with asymmetric channel conditions. We use a score-based approach with the splitting algorithm to introduce time and throughput fairness while exploiting the multi-user diversity of the network. Analytical and simulation results are given to show that the modified score-based splitting algorithm works well as a fair scheduling scheme with good spectral efficiency and reduced feedback. © 2012 IEEE.

  14. INNOVATION ANALYSIS BASED ON SCORES AT THE FIRM LEVEL

    OpenAIRE

    Cătălin George ALEXE; Cătălina Monica ALEXE; Gheorghe MILITARU

    2014-01-01

    Innovation analysis based on scores (Innovation Scorecard) is a simple way to get a quick diagnosis on the potential of innovation of a firm in its intention to achieve the innovation capability. It aims to identify and remedy the deficient aspects related to innovation management being used as a measuring tool for the innovation initiatives over time within the innovation audit. The paper aims to present the advantages and disadvantages of using the method, and the three approaches devel...

  15. Comparison of linear energy transfer scoring techniques in Monte Carlo simulations of proton beams

    International Nuclear Information System (INIS)

    Monte Carlo (MC) simulations are commonly used to study linear energy transfer (LET) distributions in therapeutic proton beams. Various techniques have been used to score LET in MC simulations. The goal of this work was to compare LET distributions obtained using different LET scoring techniques and examine the sensitivity of these distributions to changes in commonly adjusted simulation parameters. We used three different techniques to score average proton LET in TOPAS, which is a MC platform based on the Geant4 simulation toolkit. We determined the sensitivity of each scoring technique to variations in the range production thresholds for secondary electrons and protons. We also compared the depth-LET distributions that we acquired using each technique in a simple monoenergetic proton beam and in a more clinically relevant modulated proton therapy beam. Distributions of both fluence-averaged LET (LETΦ) and dose-averaged LET (LETD) were studied. We found that LETD values varied more between different scoring techniques than the LETΦ values did, and different LET scoring techniques showed different sensitivities to changes in simulation parameters. (note)

  16. Do medical students’ scores using different assessment instruments predict their scores in clinical reasoning using a computer-based simulation?

    Directory of Open Access Journals (Sweden)

    Fida M

    2015-02-01

    Full Text Available Mariam Fida,1 Salah Eldin Kassab2 1Department of Molecular Medicine, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain; 2Department of Medical Education, Faculty of Medicine, Suez Canal University, Ismailia, Egypt Purpose: The development of clinical problem-solving skills evolves over time and requires structured training and background knowledge. Computer-based case simulations (CCS have been used for teaching and assessment of clinical reasoning skills. However, previous studies examining the psychometric properties of CCS as an assessment tool have been controversial. Furthermore, studies reporting the integration of CCS into problem-based medical curricula have been limited. Methods: This study examined the psychometric properties of using CCS software (DxR Clinician for assessment of medical students (n=130 studying in a problem-based, integrated multisystem module (Unit IX during the academic year 2011–2012. Internal consistency reliability of CCS scores was calculated using Cronbach's alpha statistics. The relationships between students' scores in CCS components (clinical reasoning, diagnostic performance, and patient management and their scores in other examination tools at the end of the unit including multiple-choice questions, short-answer questions, objective structured clinical examination (OSCE, and real patient encounters were analyzed using stepwise hierarchical linear regression. Results: Internal consistency reliability of CCS scores was high (α=0.862. Inter-item correlations between students' scores in different CCS components and their scores in CCS and other test items were statistically significant. Regression analysis indicated that OSCE scores predicted 32.7% and 35.1% of the variance in clinical reasoning and patient management scores, respectively (P<0.01. Multiple-choice question scores, however, predicted only 15.4% of the variance in diagnostic performance scores (P<0.01, while

  17. Association of a Dietary Score with Incident Type 2 Diabetes: The Dietary-Based Diabetes-Risk Score (DDS)

    Science.gov (United States)

    Dominguez, Ligia J.; Bes-Rastrollo, Maira; Basterra-Gortari, Francisco Javier; Gea, Alfredo; Barbagallo, Mario; Martínez-González, Miguel A.

    2015-01-01

    Background Strong evidence supports that dietary modifications may decrease incident type 2 diabetes mellitus (T2DM). Numerous diabetes risk models/scores have been developed, but most do not rely specifically on dietary variables or do not fully capture the overall dietary pattern. We prospectively assessed the association of a dietary-based diabetes-risk score (DDS), which integrates optimal food patterns, with the risk of developing T2DM in the SUN (“Seguimiento Universidad de Navarra”) longitudinal study. Methods We assessed 17,292 participants initially free of diabetes, followed-up for a mean of 9.2 years. A validated 136-item FFQ was administered at baseline. Taking into account previous literature, the DDS positively weighted vegetables, fruit, whole cereals, nuts, coffee, low-fat dairy, fiber, PUFA, and alcohol in moderate amounts; while it negatively weighted red meat, processed meats and sugar-sweetened beverages. Energy-adjusted quintiles of each item (with exception of moderate alcohol consumption that received either 0 or 5 points) were used to build the DDS (maximum: 60 points). Incident T2DM was confirmed through additional detailed questionnaires and review of medical records of participants. We used Cox proportional hazards models adjusted for socio-demographic and anthropometric parameters, health-related habits, and clinical variables to estimate hazard ratios (HR) of T2DM. Results We observed 143 T2DM confirmed cases during follow-up. Better baseline conformity with the DDS was associated with lower incidence of T2DM (multivariable-adjusted HR for intermediate (25–39 points) vs. low (11–24) category 0.43 [95% confidence interval (CI) 0.21, 0.89]; and for high (40–60) vs. low category 0.32 [95% CI: 0.14, 0.69]; p for linear trend: 0.019). Conclusions The DDS, a simple score exclusively based on dietary components, showed a strong inverse association with incident T2DM. This score may be applicable in clinical practice to improve

  18. A Score Based Trustworthy Declaration Scheme For Vanets

    Directory of Open Access Journals (Sweden)

    A.Jenifer Sophia

    2014-03-01

    Full Text Available Vehicles are allowed to generate and broadcast messages about road conditions, such as traffic congestion and accidents to nearby vehicles in Vehicular ad hoc networks (VANETs. These kinds of messages may improve road safety and traffic efficiency of neighboring vehicles. However, messages generated by vehicles may not be reliable. Then propose the secure algorithm through a novel announcement system. The neighboring vehicle utilizes this information within a seconds through the SHA1- RSA algorithm and be aware form the road conditions. The reputation system is to find the evaluation of the reliability of the message is based on the digital score which is stored in the server.

  19. The Glasgow Prognostic Score, an inflammation based prognostic score, predicts survival in patients with hepatocellular carcinoma

    International Nuclear Information System (INIS)

    Elevated Glasgow Prognostic Score (GPS) has been related to poor prognosis in patients with hepatocellular carcinoma (HCC) undergoing surgical resection or receiving sorafenib. The aim of this study was to investigate the prognostic value of GPS in patients with various stages of the disease and with different liver functional status. One hundred and fifty patients with newly diagnosed HCC were prospectively evaluated. Patients were divided according to their GPS scores. Univariate and multivariate analyses were performed to identify clinicopathological variables associated with overall survival; the identified variables were then compared with those of other validated staging systems. Elevated GPS were associated with increased asparate aminotransferase (P<0.0001), total bilirubin (P<0.0001), decreased albumin (P<0.0001), α-fetoprotein (P=0.008), larger tumor diameter (P=0.003), tumor number (P=0.041), vascular invasion (P=0.0002), extra hepatic metastasis (P=0.02), higher Child-Pugh scores (P<0.0001), and higher Cancer Liver Italian Program scores (P<0.0001). On multivariate analysis, the elevated GPS was independently associated with worse overall survival. Our results demonstrate that the GPS can serve as an independent marker of poor prognosis in patients with HCC in various stages of disease and different liver functional status

  20. Assessment of the U.S. Department of Energy's Home Energy Scoring Tool

    Energy Technology Data Exchange (ETDEWEB)

    Roberts, David [National Renewable Energy Lab. (NREL), Golden, CO (United States); Merket, Noel [National Renewable Energy Lab. (NREL), Golden, CO (United States); Polly, Ben [National Renewable Energy Lab. (NREL), Golden, CO (United States); Heaney, Mike [National Renewable Energy Lab. (NREL), Golden, CO (United States); Casey, Sean [National Renewable Energy Lab. (NREL), Golden, CO (United States); Robertson, Joseph [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2012-07-01

    The National Renewable Energy Laboratory (NREL) conducted a series of assessments of the U.S. Department of Energy's (DOE) proposed Home Energy Scoring Tool (HEST). This report is an assessment of the 4/27/2012 release of HEST. Predictions of electric and natural gas consumption were compared with weather-normalized utility billing data for a mixture of newer and older homes located in Oregon, Wisconsin, Minnesota, North Carolina and Texas.

  1. Integrating atom-based and residue-based scoring functions for protein–protein docking

    OpenAIRE

    Vreven, Thom; Hwang, Howook; Weng, Zhiping

    2011-01-01

    Most scoring functions for protein–protein docking algorithms are either atom-based or residue-based, with the former being able to produce higher quality structures and latter more tolerant to conformational changes upon binding. Earlier, we developed the ZRANK algorithm for reranking docking predictions, with a scoring function that contained only atom-based terms. Here we combine ZRANK's atom-based potentials with five residue-based potentials published by other labs, as well as an atom-ba...

  2. "Score the Core" Web-based pathologist training tool improves the accuracy of breast cancer IHC4 scoring.

    Science.gov (United States)

    Engelberg, Jesse A; Retallack, Hanna; Balassanian, Ronald; Dowsett, Mitchell; Zabaglo, Lila; Ram, Arishneel A; Apple, Sophia K; Bishop, John W; Borowsky, Alexander D; Carpenter, Philip M; Chen, Yunn-Yi; Datnow, Brian; Elson, Sarah; Hasteh, Farnaz; Lin, Fritz; Moatamed, Neda A; Zhang, Yanhong; Cardiff, Robert D

    2015-11-01

    Hormone receptor status is an integral component of decision-making in breast cancer management. IHC4 score is an algorithm that combines hormone receptor, HER2, and Ki-67 status to provide a semiquantitative prognostic score for breast cancer. High accuracy and low interobserver variance are important to ensure the score is accurately calculated; however, few previous efforts have been made to measure or decrease interobserver variance. We developed a Web-based training tool, called "Score the Core" (STC) using tissue microarrays to train pathologists to visually score estrogen receptor (using the 300-point H score), progesterone receptor (percent positive), and Ki-67 (percent positive). STC used a reference score calculated from a reproducible manual counting method. Pathologists in the Athena Breast Health Network and pathology residents at associated institutions completed the exercise. By using STC, pathologists improved their estrogen receptor H score and progesterone receptor and Ki-67 proportion assessment and demonstrated a good correlation between pathologist and reference scores. In addition, we collected information about pathologist performance that allowed us to compare individual pathologists and measures of agreement. Pathologists' assessment of the proportion of positive cells was closer to the reference than their assessment of the relative intensity of positive cells. Careful training and assessment should be used to ensure the accuracy of breast biomarkers. This is particularly important as breast cancer diagnostics become increasingly quantitative and reproducible. Our training tool is a novel approach for pathologist training that can serve as an important component of ongoing quality assessment and can improve the accuracy of breast cancer prognostic biomarkers. PMID:26410019

  3. DIC score in pregnant women--a population based modification of the International Society on Thrombosis and Hemostasis score.

    Directory of Open Access Journals (Sweden)

    Offer Erez

    Full Text Available OBJECTIVES: The objectives of this study were: 1 To determine the component needed to generate a validated DIC score during pregnancy. 2 To validate such scoring system in the identification of patients with clinical diagnosis of DIC. MATERIAL AND METHODS: This is a population based retrospective study, including all women who gave birth at the 'Soroka University Medical Center' during the study period, and have had blood coagulation tests including complete blood cell count, prothrombin time (PT(seconds, partial thromboplastin time (aPTT, fibrinogen, and D-dimers. Nomograms for pregnancy were established, and DIC score was constructed based on ROC curve analyses. RESULTS: 1 maternal plasma fibrinogen concentrations increased during pregnancy; 2 maternal platelet count decreased gradually during gestation; 3 the PT and PTT values did not change with advancing gestation; 4 PT difference had an area under the curve (AUC of 0.96 (p<0.001, and a PT difference ≥1.55 had an 87% sensitivity and 90% specificity for the diagnosis of DIC; 5 the platelet count had an AUC of 0.87 (p<0.001, an 86% sensitivity and 71% specificity for the diagnosis of DIC; 6 fibrinogen concentrations had an AUC of 0.95 (p<0.001 and a cutoff point ≤3.9 g/L had a sensitivity of 87% and a specificity of 92% for the development of DIC; and 7 The pregnancy adjusted DIC score had an AUC of 0.975 (p<0.001 and at a cutoff point of ≥26 had a sensitivity of 88%, a specificity of 96%, a LR(+ of 22 and a LR(- of 0.125 for the diagnosis of DIC. CONCLUSION: We could establish a sensitive and specific pregnancy adjusted DIC score. The positive likelihood ratio of this score suggests that a patient with a score of ≥26 has a high probability to have DIC.

  4. Development of the Knowledge-based & Empirical Combined Scoring Algorithm (KECSA) to Score Protein-Ligand Interactions

    Science.gov (United States)

    Zheng, Zheng

    2013-01-01

    We describe a novel knowledge-based protein-ligand scoring function that employs a new definition for the reference state, allowing us to relate a statistical potential to a Lennard-Jones (LJ) potential. In this way, the LJ potential parameters were generated from protein-ligand complex structural data contained in the PDB. Forty-nine types of atomic pairwise interactions were derived using this method, which we call the knowledge-based and empirical combined scoring algorithm (KECSA). Two validation benchmarks were introduced to test the performance of KECSA. The first validation benchmark included two test sets that address the training-set and enthalpy/entropy of KECSA The second validation benchmark suite included two large-scale and five small-scale test sets to compare the reproducibility of KECSA with respect to two empirical score functions previously developed in our laboratory (LISA and LISA+), as well as to other well-known scoring methods. Validation results illustrate that KECSA shows improved performance in all test sets when compared with other scoring methods especially in its ability to minimize the RMSE. LISA and LISA+ displayed similar performance using the correlation coefficient and Kendall τ as the metric of quality for some of the small test sets. Further pathways for improvement are discussed which would KECSA more sensitive to subtle changes in ligand structure. PMID:23560465

  5. The high-density lipoprotein-adjusted SCORE model worsens SCORE-based risk classification in a contemporary population of 30 824 Europeans

    DEFF Research Database (Denmark)

    Mortensen, Martin B; Afzal, Shoaib; Nordestgaard, Børge G;

    2015-01-01

    AIMS: Recent European guidelines recommend to include high-density lipoprotein (HDL) cholesterol in risk assessment for primary prevention of cardiovascular disease (CVD), using a SCORE-based risk model (SCORE-HDL). We compared the predictive performance of SCORE-HDL with SCORE in an independent...... with SCORE, but deteriorated risk classification based on NRI. Future guidelines should consider lower decision thresholds and prioritize CVD morbidity and people above age 65....

  6. A Score Point based Email Spam Filtering Genetic Algorithm

    Directory of Open Access Journals (Sweden)

    Preeti Trivedi

    2015-12-01

    Full Text Available E-mail is one of the most essential parts of communications over internet today. However, each day we spent several minutes in deleting spam related to advertisement of products, offering loans at low interest rates, drugs etc. Though spam filters are capable to identify spam mails but spammers are constantly evolving newer methods to send spam messages to more and more people. With the advent of technology mobile devices and other portable electronic devices are now Wi-Fi enabled and internet telephony VoIP (voice over internet protocol has made communicating across the world easier and inexpensive. Social networks like Twitter, Facebook, MySpace, orkut are very general means of connecting with friends across universally. However this has opened a newer audience for spammers to exploit. Spam is not just limited to e-mail anymore, it is on VoIP in the form of unsolicited marketing or advertising phone calls, or marketing, advertising and pornography links on social network. Spam is everywhere. This paper presents a genetic algorithms based spam filtering technique whose fitness function is based on the score point. We have shown that the considered algorithm provide a good recognition rate of 84% at FPR of 0.001.

  7. Hospital Value-Based Purchasing (HVBP) – Heart Failure Scores

    Data.gov (United States)

    U.S. Department of Health & Human Services — A list of hospitals participating in the Hospital VBP Program and their performance rates and scores for the Clinical Process of Care Heart Failure measures.

  8. Virtual non-contrast CT using dual energy spectral CT: Feasibility of coronary artery calcium scoring

    Energy Technology Data Exchange (ETDEWEB)

    Song, In Young; Yi, Jeong Geun; Park, Jeong Hee [Dept. of Radiology, Konkuk University School of Medicine, Seoul (Korea, Republic of); Lee, Sung Mok; Lee, Kyung Soo; Chung, Myung Jin [Dept. of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2016-06-15

    To evaluate the feasibility of coronary artery calcium scoring based on three virtual noncontrast-enhanced (VNC) images derived from single-source spectral dual-energy CT (DECT) as compared with true noncontrast-enhanced (TNC) images. This prospective study was conducted with the approval of our Institutional Review Board. Ninety-seven patients underwent noncontrast CT followed by contrast-enhanced chest CT using single-source spectral DECT. Iodine eliminated VNC images were reconstructed using two kinds of 2-material decomposition algorithms (material density iodine-water pair [MDW], material density iodine-calcium pair [MDC]) and a material suppressed algorithm (material suppressed iodine [MSI]). Two readers independently quantified calcium on VNC and TNC images. The Spearman correlation coefficient test and Bland-Altman method were used for statistical analyses. Coronary artery calcium scores from all three VNC images showed excellent correlation with those from the TNC images (Spearman's correlation coefficient [ρ] = 0.94, 0.88, and 0.89 for MDW, MDC, and MSI, respectively; p < 0.001 for all pairs). Measured coronary calcium volumes from VNC images also correlated well with those from TNC images (ρ = 0.92, 0.87, and 0.91 for MDW, MDC, and MSI, respectively; p < 0.001 for all pairs). Among the three VNC images, coronary calcium from MDW correlated best with that from TNC. The coronary artery calcium scores and volumes were significantly lower from the VNC images than from the TNC images (p < 0.001 for all pairs). The use of VNC images from contrast-enhanced CT using dual-energy material decomposition/suppression is feasible for coronary calcium scoring. The absolute value from VNC tends to be smaller than that from TNC.

  9. Commercial Building Energy Asset Score System: Program Overview and Technical Protocol (Version 1.0)

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Na; Gorrissen, Willy J.

    2013-01-11

    The U.S. Department of Energy (DOE) is developing a national voluntary energy asset score system that includes an energy asset score tool to help building owners evaluate their buildings with respect to the score system. The goal of the energy asset score system is to facilitate cost-effective investment in energy efficiency improvements of commercial buildings. The system will allow building owners and managers to compare their building infrastructure against peers and track building upgrade progress over time. The system can also help other building stakeholders (e.g., building operators, tenants, financiers, and appraisers) understand the relative efficiency of different buildings in a way that is independent from their operations and occupancy. This report outlines the technical protocol used to generate the energy asset score, explains the scoring methodology, and provides additional details regarding the energy asset score tool. This report also describes alternative methods that were considered prior to developing the current approach. Finally, this report describes a few features of the program where alternative approaches are still under evaluation.

  10. Reliability of a consensus-based ultrasound score for tenosynovitis in rheumatoid arthritis

    DEFF Research Database (Denmark)

    Naredo, Esperanza; D'Agostino, Maria Antonietta; Wakefield, Richard J;

    2013-01-01

    OBJECTIVE: To produce consensus-based scoring systems for ultrasound (US) tenosynovitis and to assess the intraobserver and interobserver reliability of these scoring systems in rheumatoid arthritis (RA). METHODS: We undertook a Delphi process on US-defined tenosynovitis and US scoring system of...

  11. Improved base-calling and quality scores for 454 sequencing based on a Hurdle Poisson model

    Directory of Open Access Journals (Sweden)

    Beuf Kristof

    2012-11-01

    Full Text Available Abstract Background 454 pyrosequencing is a commonly used massively parallel DNA sequencing technology with a wide variety of application fields such as epigenetics, metagenomics and transcriptomics. A well-known problem of this platform is its sensitivity to base-calling insertion and deletion errors, particularly in the presence of long homopolymers. In addition, the base-call quality scores are not informative with respect to whether an insertion or a deletion error is more likely. Surprisingly, not much effort has been devoted to the development of improved base-calling methods and more intuitive quality scores for this platform. Results We present HPCall, a 454 base-calling method based on a weighted Hurdle Poisson model. HPCall uses a probabilistic framework to call the homopolymer lengths in the sequence by modeling well-known 454 noise predictors. Base-calling quality is assessed based on estimated probabilities for each homopolymer length, which are easily transformed to useful quality scores. Conclusions Using a reference data set of the Escherichia coli K-12 strain, we show that HPCall produces superior quality scores that are very informative towards possible insertion and deletion errors, while maintaining a base-calling accuracy that is better than the current one. Given the generality of the framework, HPCall has the potential to also adapt to other homopolymer-sensitive sequencing technologies.

  12. Commercial Building Energy Asset Score Program Overview and Technical Protocol (Version 1.1)

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Na; Goel, Supriya; Makhmalbaf, Atefe

    2013-08-09

    The U.S. Department of Energy (DOE) is developing a voluntary national scoring system for commercial buildings to help building owners and managers assess a building’s energy-related systems independent of operations. The goal of the score is to facilitate cost-effective investment in energy efficiency improvements of commercial buildings. The system, known as the Commercial Building Energy Asset Score, will allow building owners and managers to compare their building infrastructure against peers and track building upgrades over time. The system will also help other building stakeholders (e.g., building investors, tenants, financiers, and appraisers) understand the relative efficiency of different buildings in a way that is independent from operations and occupancy. This report outlines the technical protocol used to generate the energy asset score, explains the scoring methodology, and provides additional details regarding the energy asset scoring tool. The alternative methods that were considered prior to developing the current approach are described in the Program Overview and Technical Protocol Version 1.0.

  13. Natural history of alkaptonuria revisited: analyses based on scoring systems.

    Science.gov (United States)

    Ranganath, Lakshminarayan R; Cox, Trevor F

    2011-12-01

    Increased circulating homogentisic acid in body fluids occurs in alkaptonuria (AKU) due to lack of enzyme homogentisate dioxygenase leading in turn to conversion of HGA to a pigmented melanin-like polymer, known as ochronosis. The tissue damage in AKU is due to ochronosis. A potential treatment, a drug called nitisinone, to decrease formation of HGA is available. However, deploying nitisinone effectively requires its administration at the most optimal time in the natural history. AKU has a long apparent latent period before overt ochronosis develops. The rate of change of ochronosis and its consequences over time following its recognition has not been fully described in any quantitative manner. Two potential tools are described that were used to quantitate disease burden in AKU. One tool describes scoring the clinical features that includes clinical assessments, investigations and questionnaires in 15 patients with AKU. The second tool describes a scoring system that only includes items obtained from questionnaires in 44 people with AKU. Analysis of the data reveals distinct phases of the disease, a pre-ochronotic phase and an ochronotic phase. The ochronotic phase appears to demonstrate an earlier slower progression followed by a rapidly progressive phase. The rate of change of the disease will have implications for monitoring the course of the disease as well as decide on the most appropriate time that treatment should be started for it to be effective either in prevention or arrest of the disease. PMID:21748407

  14. Feature and Score Fusion Based Multiple Classifier Selection for Iris Recognition

    OpenAIRE

    Md. Rabiul Islam

    2014-01-01

    The aim of this work is to propose a new feature and score fusion based iris recognition approach where voting method on Multiple Classifier Selection technique has been applied. Four Discrete Hidden Markov Model classifiers output, that is, left iris based unimodal system, right iris based unimodal system, left-right iris feature fusion based multimodal system, and left-right iris likelihood ratio score fusion based multimodal system, is combined using voting method to achieve the final reco...

  15. Scoring Divergent Thinking Tests by Computer With a Semantics-Based Algorithm

    Directory of Open Access Journals (Sweden)

    Kenes Beketayev

    2016-05-01

    Full Text Available Divergent thinking (DT tests are useful for the assessment of creative potentials. This article reports the semantics-based algorithmic (SBA method for assessing DT. This algorithm is fully automated: Examinees receive DT questions on a computer or mobile device and their ideas are immediately compared with norms and semantic networks. This investigation compared the scores generated by the SBA method with the traditional methods of scoring DT (i.e., fluency, originality, and flexibility. Data were collected from 250 examinees using the “Many Uses Test” of DT. The most important finding involved the flexibility scores from both scoring methods. This was critical because semantic networks are based on conceptual structures, and thus a high SBA score should be highly correlated with the traditional flexibility score from DT tests. Results confirmed this correlation (r = .74. This supports the use of algorithmic scoring of DT. The nearly-immediate computation time required by SBA method may make it the method of choice, especially when it comes to moderate- and large-scale DT assessment investigations. Correlations between SBA scores and GPA were insignificant, providing evidence of the discriminant and construct validity of SBA scores. Limitations of the present study and directions for future research are offered.

  16. Scoring Divergent Thinking Tests by Computer With a Semantics-Based Algorithm.

    Science.gov (United States)

    Beketayev, Kenes; Runco, Mark A

    2016-05-01

    Divergent thinking (DT) tests are useful for the assessment of creative potentials. This article reports the semantics-based algorithmic (SBA) method for assessing DT. This algorithm is fully automated: Examinees receive DT questions on a computer or mobile device and their ideas are immediately compared with norms and semantic networks. This investigation compared the scores generated by the SBA method with the traditional methods of scoring DT (i.e., fluency, originality, and flexibility). Data were collected from 250 examinees using the "Many Uses Test" of DT. The most important finding involved the flexibility scores from both scoring methods. This was critical because semantic networks are based on conceptual structures, and thus a high SBA score should be highly correlated with the traditional flexibility score from DT tests. Results confirmed this correlation (r = .74). This supports the use of algorithmic scoring of DT. The nearly-immediate computation time required by SBA method may make it the method of choice, especially when it comes to moderate- and large-scale DT assessment investigations. Correlations between SBA scores and GPA were insignificant, providing evidence of the discriminant and construct validity of SBA scores. Limitations of the present study and directions for future research are offered. PMID:27298632

  17. Application of a computed tomography based cystic fibrosis scoring system to chest tomosynthesis

    Science.gov (United States)

    Söderman, Christina; Johnsson, Åse; Vikgren, Jenny; Rystedt, Hans; Ivarsson, Jonas; Rossi Norrlund, Rauni; Nyberg Andersson, Lena; Bâth, Magnus

    2013-03-01

    In the monitoring of progression of lung disease in patients with cystic fibrosis (CF), recurrent computed tomography (CT) examinations are often used. The relatively new imaging technique chest tomosynthesis (CTS) may be an interesting alternative in the follow-up of these patients due to its visualization of the chest in slices at radiation doses and costs significantly lower than is the case with CT. A first step towards introducing CTS imaging in the diagnostics of CF patients is to establish a scoring system appropriate for evaluating the severity of CF pulmonary disease based on findings in CTS images. Previously, several such CF scoring systems based on CT imaging have been published. The purpose of the present study was to develop a CF scoring system for CTS, by starting from an existing scoring system dedicated for CT images and making modifications regarded necessary to make it appropriate for use with CTS images. In order to determine any necessary changes, three thoracic radiologists independently used a scoring system dedicated for CT on both CT and CTS images from CF patients. The results of the scoring were jointly evaluated by all the observers, which lead to suggestions for changes to the scoring system. Suggested modifications include excluding the scoring of air trapping and doing the scoring of the findings in quadrants of the image instead of in each lung lobe.

  18. Scoring Divergent Thinking Tests by Computer With a Semantics-Based Algorithm

    Science.gov (United States)

    Beketayev, Kenes; Runco, Mark A.

    2016-01-01

    Divergent thinking (DT) tests are useful for the assessment of creative potentials. This article reports the semantics-based algorithmic (SBA) method for assessing DT. This algorithm is fully automated: Examinees receive DT questions on a computer or mobile device and their ideas are immediately compared with norms and semantic networks. This investigation compared the scores generated by the SBA method with the traditional methods of scoring DT (i.e., fluency, originality, and flexibility). Data were collected from 250 examinees using the “Many Uses Test” of DT. The most important finding involved the flexibility scores from both scoring methods. This was critical because semantic networks are based on conceptual structures, and thus a high SBA score should be highly correlated with the traditional flexibility score from DT tests. Results confirmed this correlation (r = .74). This supports the use of algorithmic scoring of DT. The nearly-immediate computation time required by SBA method may make it the method of choice, especially when it comes to moderate- and large-scale DT assessment investigations. Correlations between SBA scores and GPA were insignificant, providing evidence of the discriminant and construct validity of SBA scores. Limitations of the present study and directions for future research are offered. PMID:27298632

  19. Severity assessment of pulmonary embolism using dual energy CT - correlation of a pulmonary perfusion defect score with clinical and morphological parameters of blood oxygenation and right ventricular failure

    Energy Technology Data Exchange (ETDEWEB)

    Thieme, Sven F. [Ludwig-Maximilians-Universitaet, Department of Clinical Radiology, Muenchen (Germany); Institut fuer Klinische Radiologie der LMU Muenchen, Muenchen (Germany); Ashoori, Nima; Bamberg, Fabian; Sommer, Wieland H.; Johnson, Thorsten R.C.; Maxien, Daniel; Helck, Andreas D.; Reiser, Maximilian F.; Nikolaou, Konstantin [Ludwig-Maximilians-Universitaet, Department of Clinical Radiology, Muenchen (Germany); Leuchte, Hanno; Becker, Alexander [Ludwig-Maximilians-Universitaet, Department of Medicine I, Muenchen (Germany); Behr, Juergen [Ludwig-Maximilians-Universitaet, Department of Medicine I, Muenchen (Germany); Berufsgenossenschaftliches Universitaetsklinikum Bergmannsheil GmbH Ruhr-Universitaet Bochum, Department of Medicine III, Bochum (Germany)

    2012-02-15

    To correlate a Dual Energy (DE)-based visual perfusion defect scoring system with established CT-based and clinical parameters of pulmonary embolism (PE) severity. In 63 PE patients, DE perfusion maps were visually scored for perfusion defects (P-score). Vascular obstruction was quantified using the Mastora score. Both scores were correlated with short-axis diameters of the right and left ventricle, their ratio (RV/LV ratio), width of the pulmonary trunk, a number of clinical parameters and each other. Univariate and multivariate analyses were performed. Times to generate both scores were recorded. After univariate and multivariate analysis, a significant (p < 0.05) correlation with the P-score was shown for the Mastora score (r = 0.65), RV/LV ratio (r = 0.47), width of the pulmonary trunk (r = 0.26), troponin I (r = 0.43) and PaO{sub 2} (r = -0.50). For the left ventricular diameter, only univariate analysis showed a significant correlation. Mastora score correlated significantly with RV/LV ratio (r = 0.36), width of the pulmonary trunk (r = 0.27), PaO{sub 2} (r = -0.41) and troponin I (r = 0.37). Mean time for generating the P-score was significantly shorter than for the Mastora score. A DE-based P-score correlates with a number of parameters of PE severity. It might be easier and faster to perform than some traditional CT scoring methods for vascular obstruction. (orig.)

  20. The new large-area wide-angle ground-based cosmic-ray and gamma-ray detector SCORE

    Science.gov (United States)

    Tluczykont, Martin; Hampf, Daniel; Horns, Dieter; Kneiske, Tanja; Rowell, Gavin

    We propose to explore the so-far poorly measured cosmic-ray and gamma-ray sky (accelerator sky) in the energy range from 10 TeV to 1 EeV with the new large-area (10 square-km) wide-angle (1 sr) air Cherenkov detector SCORE (Study for a Cosmic ORigin Explorer). The SCORE detector concept is based on non-imaging Cherenkov light-front sampling with sensitive large-area (order of square-m) detector modules, distributed over an array covering a total area of at least 10 square-kilometers. The lateral intensity and arrival-time distribu-tions will be sampled with high sensitivity up to large distances from the shower core. An extension of the SCORE detector to HiSCORE (Hundred Square-km Cosmic ORigin Explorer) is planned. With SCORE (and HiSCORE) fundamental physics questions can be addressed, including the origin of charged Galactic cosmic rays, diffuse gamma-ray emission from the Galactic plane and the local super-cluster, attenuation by Galactic interstellar radiaton fields and the cosmic microwave background and studies of possible effects on this attenuation by photon/axion conversion, hidden-sector photon oscillations or violation of Lorentz invariance. Further motivations are spectral and chemical composition measurements of charged cosmic rays from 100 TeV to 1 EeV and independent measurements of the proton-proton inelastic cross-section overlapping with and exceeding LHC energies. First simulations show that already SCORE has the potential to be competitive with existing and planned experiments above 10 TeV and outperforming above 100 TeV. The physics moti-vations, the detector concept / performance expectations and the status of our project will be presented.

  1. Can We Do Better in Unimodal Biometric Systems? A Rank-Based Score Normalization Framework.

    Science.gov (United States)

    Moutafis, Panagiotis; Kakadiaris, Ioannis A

    2015-12-01

    Biometric systems use score normalization techniques and fusion rules to improve recognition performance. The large amount of research on score fusion for multimodal systems raises an important question: can we utilize the available information from unimodal systems more effectively? In this paper, we present a rank-based score normalization framework that addresses this problem. Specifically, our approach consists of three algorithms: 1) partition the matching scores into subsets and normalize each subset independently; 2) utilize the gallery versus gallery matching scores matrix (i.e., gallery-based information); and 3) dynamically augment the gallery in an online fashion. We invoke the theory of stochastic dominance along with results of prior research to demonstrate when and why our approach yields increased performance. Our framework: 1) can be used in conjunction with any score normalization technique and any fusion rule; 2) is amenable to parallel programming; and 3) is suitable for both verification and open-set identification. To assess the performance of our framework, we use the UHDB11 and FRGC v2 face datasets. Specifically, the statistical hypothesis tests performed illustrate that the performance of our framework improves as we increase the number of samples per subject. Furthermore, the corresponding statistical analysis demonstrates that increased separation between match and nonmatch scores is obtained for each probe. Besides the benefits and limitations highlighted by our experimental evaluation, results under optimal and pessimal conditions are also presented to offer better insights. PMID:25546871

  2. A mass accuracy sensitive probability based scoring algorithm for database searching of tandem mass spectrometry data

    Directory of Open Access Journals (Sweden)

    Freitas Michael A

    2007-04-01

    Full Text Available Abstract Background Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS has become one of the most used tools in mass spectrometry based proteomics. Various algorithms have since been developed to automate the process for modern high-throughput LC-MS/MS experiments. Results A probability based statistical scoring model for assessing peptide and protein matches in tandem MS database search was derived. The statistical scores in the model represent the probability that a peptide match is a random occurrence based on the number or the total abundance of matched product ions in the experimental spectrum. The model also calculates probability based scores to assess protein matches. Thus the protein scores in the model reflect the significance of protein matches and can be used to differentiate true from random protein matches. Conclusion The model is sensitive to high mass accuracy and implicitly takes mass accuracy into account during scoring. High mass accuracy will not only reduce false positives, but also improves the scores of true positive matches. The algorithm is incorporated in an automated database search program MassMatrix.

  3. Supporting the Co-operative Organisation of Rational Energy Use (SCORE). Bulgaria Country Document

    International Nuclear Information System (INIS)

    SCORE stands for Supporting the Co-operative Organisation of Rational Energy Use. It aims at assisting the social transformation in the Central and Eastern European countries by creating self-supporting structures that are able to stimulate the efficient use of energy in end-user sectors. This document aims at presenting an in-depth institutional analysis of the energy efficiency situation in Bulgaria, including the current situation with regard to energy supply, consumption and environmental aspects, as well as an analysis of energy efficiency policies, instruments and organisations. Also, the document identifies problems related to energy efficiency in Bulgaria and indicates the areas of actions for an integrated SCORE programme in Bulgaria. The input for this process was provided by a survey among the main actors in the field, consisting of a questionnaire and interviews and a review of available information. The results were discussed in a workshop attended by the main stakeholders. The main characteristics of the Bulgarian energy sector are summarised in chapter 2. They indicate a high dependency on imported resources, a low quality of domestic fuels, a relatively high energy intensity of production and a low efficiency at supply and demand side with consider able potential for improvement. The restructuring of the sector has started but the process is far from completed. In the main towns heat is mainly supplied by district heating generated partly in co-generation plants. Gas distribution for public and residential buildings is quickly developing. In Chapter 3 the existing policies and actors are described and a 'roadmap' for energy efficiency actors is given. This provides the basis for defining the priorities for energy efficiency improvements presented in Chapter 4, by analysing the tools, policy instruments and organisations. Barriers and priority actions were defined in relation to the national policy level, the institutional structure, financial and

  4. Validating an objective video-based dyskinesia severity score in Parkinson’s disease patients

    OpenAIRE

    Rao, Anusha Sathyanarayanan; Dawant, Benoit M.; Bodenheimer, Robert E.; Li, Rui; Fang, John; Phibbs, Fenna; Hedera, Peter; Davis, Thomas

    2012-01-01

    Dyskinesia is a common side effect of prolonged dopaminergic therapy in Parkinson’s disease patients. Assessing the severity of dyskinesia can help develop better pharmacological and surgical interventions. We have developed a semi-automatic video-based objective dyskinesia quantifying measure called the severity score (SVS) that was evaluated on 35 patient videos. We present a study to evaluate the utility of our severity score and compare its performance to clinical ratings of neurologists....

  5. Liver stiffness measurement-based scoring system for significant inflammation related to chronic hepatitis B.

    Directory of Open Access Journals (Sweden)

    Mei-Zhu Hong

    Full Text Available Liver biopsy is indispensable because liver stiffness measurement alone cannot provide information on intrahepatic inflammation. However, the presence of fibrosis highly correlates with inflammation. We constructed a noninvasive model to determine significant inflammation in chronic hepatitis B patients by using liver stiffness measurement and serum markers.The training set included chronic hepatitis B patients (n = 327, and the validation set included 106 patients; liver biopsies were performed, liver histology was scored, and serum markers were investigated. All patients underwent liver stiffness measurement.An inflammation activity scoring system for significant inflammation was constructed. In the training set, the area under the curve, sensitivity, and specificity of the fibrosis-based activity score were 0.964, 91.9%, and 90.8% in the HBeAg(+ patients and 0.978, 85.0%, and 94.0% in the HBeAg(- patients, respectively. In the validation set, the area under the curve, sensitivity, and specificity of the fibrosis-based activity score were 0.971, 90.5%, and 92.5% in the HBeAg(+ patients and 0.977, 95.2%, and 95.8% in the HBeAg(- patients. The liver stiffness measurement-based activity score was comparable to that of the fibrosis-based activity score in both HBeAg(+ and HBeAg(- patients for recognizing significant inflammation (G ≥3.Significant inflammation can be accurately predicted by this novel method. The liver stiffness measurement-based scoring system can be used without the aid of computers and provides a noninvasive alternative for the prediction of chronic hepatitis B-related significant inflammation.

  6. Liver Stiffness Measurement-Based Scoring System for Significant Inflammation Related to Chronic Hepatitis B

    Science.gov (United States)

    Hong, Mei-Zhu; Zhang, Ru-Mian; Chen, Guo-Liang; Huang, Wen-Qi; Min, Feng; Chen, Tian; Xu, Jin-Chao; Pan, Jin-Shui

    2014-01-01

    Objectives Liver biopsy is indispensable because liver stiffness measurement alone cannot provide information on intrahepatic inflammation. However, the presence of fibrosis highly correlates with inflammation. We constructed a noninvasive model to determine significant inflammation in chronic hepatitis B patients by using liver stiffness measurement and serum markers. Methods The training set included chronic hepatitis B patients (n = 327), and the validation set included 106 patients; liver biopsies were performed, liver histology was scored, and serum markers were investigated. All patients underwent liver stiffness measurement. Results An inflammation activity scoring system for significant inflammation was constructed. In the training set, the area under the curve, sensitivity, and specificity of the fibrosis-based activity score were 0.964, 91.9%, and 90.8% in the HBeAg(+) patients and 0.978, 85.0%, and 94.0% in the HBeAg(−) patients, respectively. In the validation set, the area under the curve, sensitivity, and specificity of the fibrosis-based activity score were 0.971, 90.5%, and 92.5% in the HBeAg(+) patients and 0.977, 95.2%, and 95.8% in the HBeAg(−) patients. The liver stiffness measurement-based activity score was comparable to that of the fibrosis-based activity score in both HBeAg(+) and HBeAg(−) patients for recognizing significant inflammation (G ≥3). Conclusions Significant inflammation can be accurately predicted by this novel method. The liver stiffness measurement-based scoring system can be used without the aid of computers and provides a noninvasive alternative for the prediction of chronic hepatitis B-related significant inflammation. PMID:25360742

  7. Developing points-based risk-scoring systems in the presence of competing risks.

    Science.gov (United States)

    Austin, Peter C; Lee, Douglas S; D'Agostino, Ralph B; Fine, Jason P

    2016-09-30

    Predicting the occurrence of an adverse event over time is an important issue in clinical medicine. Clinical prediction models and associated points-based risk-scoring systems are popular statistical methods for summarizing the relationship between a multivariable set of patient risk factors and the risk of the occurrence of an adverse event. Points-based risk-scoring systems are popular amongst physicians as they permit a rapid assessment of patient risk without the use of computers or other electronic devices. The use of such points-based risk-scoring systems facilitates evidence-based clinical decision making. There is a growing interest in cause-specific mortality and in non-fatal outcomes. However, when considering these types of outcomes, one must account for competing risks whose occurrence precludes the occurrence of the event of interest. We describe how points-based risk-scoring systems can be developed in the presence of competing events. We illustrate the application of these methods by developing risk-scoring systems for predicting cardiovascular mortality in patients hospitalized with acute myocardial infarction. Code in the R statistical programming language is provided for the implementation of the described methods. © 2016 The Authors. Statistics in Medicine published by John Wiley & Sons Ltd. PMID:27197622

  8. Defining Emergency Department Necessary Policies Based on Clinical Governance Accreditation Scores

    Directory of Open Access Journals (Sweden)

    Mehrdad Esmailian

    2015-05-01

    Full Text Available Introduction: The role of accreditation scheme in quality improvement of emergency departments (ED has not been thoroughly evaluated in studies. Therefore, this study was designed to appraise the effects of policies defined based on clinical governance accreditation scores, on improvement of the procedures in ED. Methods: The present cohort study was carried out in the ED of Alzahra University Hospital, Isfahan, Iran in 2012-2013. In 2012 the deficiencies in ED of this hospital was determined based on clinical governance indicators. Then the deficiencies were classified based on their importance and changes were made in the ED. Finally, the effects of the changes were evaluated in August 2013. Results: The evaluation made in 2012 showed that 23 clinical and non-clinical procedures were carried out with deficiencies. Over the mentioned period, 6 (26.1% procedures were not done at all, while 17 (73.9% were done without a policy and irregularly. The overall score for clinical and non-clinical procedures in the ED before carrying out the accreditation scheme was 43 / 230 (18.7% of the maximum possible score. The score was raised to 222 equal to 96.5% of the maximum possible score after carrying out the scheme. This increase was statistically significant (p < 0.001. Conclusion: The findings of the present study showed that defining policies for improving the procedures carried out in ED based on accreditation scheme leads to improvement of medical services in ED.

  9. Preoperative risk score predicting 90-day mortality after liver resection in a population-based study.

    Science.gov (United States)

    Chang, Chun-Ming; Yin, Wen-Yao; Su, Yu-Chieh; Wei, Chang-Kao; Lee, Cheng-Hung; Juang, Shiun-Yang; Chen, Yi-Ting; Chen, Jin-Cherng; Lee, Ching-Chih

    2014-09-01

    The impact of important preexisting comorbidities, such as liver and renal disease, on the outcome of liver resection remains unclear. Identification of patients at risk of mortality will aid in improving preoperative preparations. The purpose of this study is to develop and validate a population-based score based on available preoperative and predictable parameters predicting 90-day mortality after liver resection using data from a hepatitis endemic country.We identified 13,159 patients who underwent liver resection between 2002 and 2006 in the Taiwan National Health Insurance Research Database. In a randomly selected half of the total patients, multivariate logistic regression analysis was used to develop a prediction score for estimating the risk of 90-day mortality by patient demographics, preoperative liver disease and comorbidities, indication for surgery, and procedure type. The score was validated with the remaining half of the patients.Overall 90-day mortality was 3.9%. Predictive characteristics included in the model were age, preexisting cirrhosis-related complications, ischemic heart disease, heart failure, cerebrovascular disease, renal disease, malignancy, and procedure type. Four risk groups were stratified by mortality scores of 1.1%, 2.2%, 7.7%, and 15%. Preexisting renal disease and cirrhosis-related complications were the strongest predictors. The score discriminated well in both the derivation and validation sets with c-statistics of 0.75 and 0.75, respectively.This population-based score could identify patients at risk of 90-day mortality before liver resection. Preexisting renal disease and cirrhosis-related complications had the strongest influence on mortality. This score enables preoperative risk stratification, decision-making, quality assessment, and counseling for individual patients. PMID:25211044

  10. An application of dichotomous and polytomous Rasch models for scoring energy insecurity

    International Nuclear Information System (INIS)

    Household food security in the United States has been extensively researched and a number of indexes have been generated. However, household energy security has been largely ignored even though low-income households spend almost equal income shares on food and energy. This paper uses Rasch models and household responses to energy security questions in the 2005 Residential Energy Consumption Survey to generate an energy insecurity index that is consistent with those found in the food insecurity literature. The analysis yields several important findings for the generation of policy relevant household energy insecurity indexes. Questions that indicate reduction of basic expenditures, such as food, clothing, and shelter, are easiest for households to affirm implying low exposure to energy insecurity. Conversely, questions that concern households leaving the residence due to extreme temperatures consistently imply high exposure to energy insecurity. Households that score in the top decile of the energy insecurity index are more likely to be headed by single-females, be younger, and have a Black household head. Rasch models also identify flaws within survey. Particularly, the scope of the questions is quite broad and a refinement of the survey questions to focus on specific attributes of energy insecurity would likely improve future energy security indexes. - Highlights: ► A novel household energy insecurity index is generated for low-income U.S. families. ► Severely energy insecure households have unique characteristics. ► Energy insecure households are more likely to participate in LIHEAP. ► RECS survey questions should be modified for an improved energy insecurity index.

  11. Ultra-high energy gamma-ray astronomy. From Tunka-HiSCORE to TAIGA

    Energy Technology Data Exchange (ETDEWEB)

    Tluczykont, Martin [Hamburg Univ., Institut fuer Experimentalphysik, Luruper Chaussee 149, 22761 Hamburg (Germany); Collaboration: TAIGA collaboration

    2015-07-01

    In the past 3 years, the Tunka-HiSCORE collaboration has installed HiSCORE timing air Cherenkov detectors in the Tunka valley in Siberia. Since October 2013, a 9-station prototype array is in operation. These activities have merged into the recently founded TAIGA collaboration, which is currently building a non-imaging air Cherenkov array consisting today of 29 stations, which will be upgraded to 1 square-km. Furthermore, the deployment of a 4m diameter imaging air Cherenkov telescope is planned within 2015. Our aim is to combine the timing and imaging techniques on a large scale in order to optimize the air Cherenkov detection technique for energies above 10 TeV and up to several 100 TeV. Simulations show a clear potential of the planned hybrid event reconstruction. The status of our experiment and our future plans are presented.

  12. The correlationship between the metabolizable energy content, chemical composition and color score in different sources of corn DDGS

    Institute of Scientific and Technical Information of China (English)

    Yong-Z Jie; Jian-Y Zhang; Li-H Zhao; Qiu-G Maand Cheng Ji

    2014-01-01

    Background:This study was conducted to evaluate the apparent metabolizable energy (AME) and true metabolizable energy (TME) contents in 30 sources of corn distillers dried grains with solubles (DDGS) in adult roosters, and establish the prediction equations to estimate the AME and TME value based on its chemical Methods:Twenty-eight sources of corn DDGS made from several processing plants in 11 provinces of China and others imported from the United States. DDGS were analyzed for their metabolizable energy (ME) contents, measured for color score and chemical composition (crude protein, crude fat, ash, neutral detergent fiber, acid detergent fiber), to predict the equation of ME in DDGS. A precision-fed rooster assay was used, each DDGS sample was tube fed (50 g) to adult roosters. The experiment was conducted as a randomized incomplete block design with 3 periods. Ninety-five adult roosters were used in each period, with 90 being fed the DDGS samples and 5 being fasted to estimate basal endogenous energy losses. Results:Results showed that the AME ranged from 5.93 to 12.19 MJ/kg, TME ranged from 7.28 to 13.54 MJ/kg. Correlations were found between ME and ash content (-0.64, P<0.01) and between ME and yellowness score (0.39, P<0.05) of the DDGS samples. Furthermore, the best-fit regression equation for AME content of DDGS based on chemical composition and color score was AME=6.57111+0.51475 GE-0.10003 NDF+0.13380 ADF+0.07057 fat-0.57029 ash-0.02437 L (R2=0.70). The best-fit regression equation for TME content of DDGS was TME=7.92283+0.51475 GE-0.10003 NDF+0.13380 ADF+0.07057 fat-0.57029 ash-0.02437 L (R2=0.70). Conclusions:This experiment suggested that measuring the chemical composition and color score of a corn DDGS sample may provide a quality parameter for identifying corn DDGS sources energy digestibility and metabolizable energy content.

  13. Optimal query-based relevance feedback in medical image retrieval using score fusion-based classification.

    Science.gov (United States)

    Behnam, Mohammad; Pourghassem, Hossein

    2015-04-01

    In this paper, a new content-based medical image retrieval (CBMIR) framework using an effective classification method and a novel relevance feedback (RF) approach are proposed. For a large-scale database with diverse collection of different modalities, query image classification is inevitable due to firstly, reducing the computational complexity and secondly, increasing influence of data fusion by removing unimportant data and focus on the more valuable information. Hence, we find probability distribution of classes in the database using Gaussian mixture model (GMM) for each feature descriptor and then using the fusion of obtained scores from the dependency probabilities, the most relevant clusters are identified for a given query. Afterwards, visual similarity of query image and images in relevant clusters are calculated. This method is performed separately on all feature descriptors, and then the results are fused together using feature similarity ranking level fusion algorithm. In the RF level, we propose a new approach to find the optimal queries based on relevant images. The main idea is based on density function estimation of positive images and strategy of moving toward the aggregation of estimated density function. The proposed framework has been evaluated on ImageCLEF 2005 database consisting of 10,000 medical X-ray images of 57 semantic classes. The experimental results show that compared with the existing CBMIR systems, our framework obtains the acceptable performance both in the image classification and in the image retrieval by RF. PMID:25246167

  14. Feature and Score Fusion Based Multiple Classifier Selection for Iris Recognition

    Directory of Open Access Journals (Sweden)

    Md. Rabiul Islam

    2014-01-01

    Full Text Available The aim of this work is to propose a new feature and score fusion based iris recognition approach where voting method on Multiple Classifier Selection technique has been applied. Four Discrete Hidden Markov Model classifiers output, that is, left iris based unimodal system, right iris based unimodal system, left-right iris feature fusion based multimodal system, and left-right iris likelihood ratio score fusion based multimodal system, is combined using voting method to achieve the final recognition result. CASIA-IrisV4 database has been used to measure the performance of the proposed system with various dimensions. Experimental results show the versatility of the proposed system of four different classifiers with various dimensions. Finally, recognition accuracy of the proposed system has been compared with existing N hamming distance score fusion approach proposed by Ma et al., log-likelihood ratio score fusion approach proposed by Schmid et al., and single level feature fusion approach proposed by Hollingsworth et al.

  15. Feature and score fusion based multiple classifier selection for iris recognition.

    Science.gov (United States)

    Islam, Md Rabiul

    2014-01-01

    The aim of this work is to propose a new feature and score fusion based iris recognition approach where voting method on Multiple Classifier Selection technique has been applied. Four Discrete Hidden Markov Model classifiers output, that is, left iris based unimodal system, right iris based unimodal system, left-right iris feature fusion based multimodal system, and left-right iris likelihood ratio score fusion based multimodal system, is combined using voting method to achieve the final recognition result. CASIA-IrisV4 database has been used to measure the performance of the proposed system with various dimensions. Experimental results show the versatility of the proposed system of four different classifiers with various dimensions. Finally, recognition accuracy of the proposed system has been compared with existing N hamming distance score fusion approach proposed by Ma et al., log-likelihood ratio score fusion approach proposed by Schmid et al., and single level feature fusion approach proposed by Hollingsworth et al. PMID:25114676

  16. International Energy Security Indicators and Turkey’s Energy Security Risk Score

    OpenAIRE

    Gelengul KOCASLAN

    2014-01-01

    Energy security has been a priority for many countries. What makes energy security that important is; its bilateral relationship with economic, political, social, environmental sustainability and military issues. As an inevitable consequence of globalization cooperation in the field has been a must and it is required international energy security indicators to make energy security risk evaluations in order to establish adequate policies. The aim of the study is to review energy security withi...

  17. Information System Of Student Score SMA Negeri 1 Tegal Based On Short Message Service (SMS Gateway

    Directory of Open Access Journals (Sweden)

    Zaenul Arif

    2016-06-01

    Full Text Available Student Score at the agency school is one measure of the success of students in learning the material presented. In the old system the parents have not been getting the value directly from the school except at the end of each semester, making them difficult to know the value of their children's development during school. To provide score transparency to students and parents needed an information system score subjects in an easy and fast data access. By identifying the problem is analyzing the old system to identify the weaknesses of the system. Thus the new system will increase. Analysis of the weakness of the old system using PIECES categories (Performance, Information, Economy, Control, Eficiency, and Service. In fulfilling these conditions, build up lesson student score information system of Short Message Service (SMS Gateway Based. The system is built using Gammu software and using the programming language PHP. By using SMS to obtain the score of the data is expected to provide convenience for parents to monitor learning outcomes of their children’s in school.

  18. Multi-view score fusion for content-based mammogram retrieval

    Science.gov (United States)

    Dhahbi, Sami; Barhoumi, Walid; Zagrouba, Ezzeddine

    2015-12-01

    Screening mammography provides two views for each breast: Medio-Lateral Oblique (MLO) and Cranial-Caudal (CC) views. However, current content based image retrieval (CBIR) systems analyze each view independently, in spite of their complementarities. To further improve the retrieval performance, this paper introduces a two-view CBIR system that combines retrieval results of MLO and CC views. First, we computed the similarity scores between MLO (resp. CC) ROIs in the database and the MLO (resp. CC) query ROI. These ROIs are characterized using curvelet moments. Then, a new linear weighted sum scheme combines MLO and CC scores; it assigns weights for each view according to the distribution of the classes of its neighbors. The ROIs having the highest fused scores are displayed to the radiologist and used to compute the malignancy likelihood of the lesion. Experiments performed on mammograms from the Digital Database for Screening Mammography (DDSM) show the effectiveness of the proposed method.

  19. Development of a Food Group-Based Diet Score and Its Association with Bone Mineral Density in the Elderly: The Rotterdam Study

    Directory of Open Access Journals (Sweden)

    Ester A.L. de Jonge

    2015-08-01

    Full Text Available No diet score exists that summarizes the features of a diet that is optimal for bone mineral density (BMD in the elderly. Our aims were (a to develop a BMD-Diet Score reflecting a diet that may be beneficial for BMD based on the existing literature, and (b to examine the association of the BMD-Diet Score and the Healthy Diet Indicator, a score based on guidelines of the World Health Organization, with BMD in Dutch elderly participating in a prospective cohort study, the Rotterdam Study (n = 5144. Baseline dietary intake, assessed using a food frequency questionnaire, was categorized into food groups. Food groups that were consistently associated with BMD in the literature were included in the BMD-Diet Score. BMD was measured repeatedly and was assessed using dual energy X-ray absorptiometry. The BMD-Diet Score considered intake of vegetables, fruits, fish, whole grains, legumes/beans and dairy products as “high-BMD” components and meat and confectionary as “low-BMD” components. After adjustment, the BMD-Diet Score was positively associated with BMD (β (95% confidence interval = 0.009 (0.005, 0.012 g/cm2 per standard deviation. This effect size was approximately three times as large as has been observed for the Healthy Diet Indicator. The food groups included in our BMD-Diet Score could be considered in the development of future dietary guidelines for healthy ageing.

  20. A score based on screening tests to differentiate mild cognitive impairment from subjective memory complaints

    Directory of Open Access Journals (Sweden)

    Fábio Henrique de Gobbi Porto

    2013-09-01

    Full Text Available It is not easy to differentiate patients with mild cognitive impairment (MCI from subjective memory complainers (SMC. Assessments with screening cognitive tools are essential, particularly in primary care where most patients are seen. The objective of this study was to evaluate the diagnostic accuracy of screening cognitive tests and to propose a score derived from screening tests. Elderly subjects with memory complaints were evaluated using the Mini Mental State Examination (MMSE and the Brief Cognitive Battery (BCB. We added two delayed recalls in the MMSE (a delayed recall and a late-delayed recall, LDR, and also a phonemic fluency test of letter P fluency (LPF. A score was created based on these tests. The diagnoses were made on the basis of clinical consensus and neuropsychological testing. Receiver operating characteristic curve analyses were used to determine area under the curve (AUC, the sensitivity and specificity for each test separately and for the final proposed score. MMSE, LDR, LPF and delayed recall of BCB scores reach statistically significant differences between groups (P=0.000, 0.03, 0.001 and 0.01, respectively. Sensitivity, specificity and AUC were MMSE: 64%, 79% and 0.75 (cut off <29; LDR: 56%, 62% and 0.62 (cut off <3; LPF: 71%, 71% and 0.71 (cut off <14; delayed recall of BCB: 56%, 82% and 0.68 (cut off <9. The proposed score reached a sensitivity of 88% and 76% and specificity of 62% and 75% for cut off over 1 and over 2, respectively. AUC were 0.81. In conclusion, a score created from screening tests is capable of discriminating MCI from SMC with moderate to good accurancy.

  1. Heart Transplant Survival Based on Recipient and Donor Risk Scoring: A UNOS Database Analysis.

    Science.gov (United States)

    Trivedi, Jaimin R; Cheng, Allen; Ising, Mickey; Lenneman, Andrew; Birks, Emma; Slaughter, Mark S

    2016-01-01

    Unlike the lung allocation score, currently, there is no quantitative scoring system available for patients on heart transplant waiting list. By using United Network for Organ Sharing (UNOS) data, we aim to generate a scoring system based on the recipient and donor risk factors to predict posttransplant survival. Available UNOS data were queried between 2005 and 2013 for heart transplant recipients aged ≥18 years to create separate cox-proportional hazard models for recipient and donor risk scoring. On the basis of risk scores, recipients were divided into five groups and donors into three groups. Kaplan-Meier curves were used for survival. Total 17,131 patients had heart transplant within specified time period. Major factors within high-risk groups were body mass index > 30 kg/m (46%), mean pulmonary artery pressure >30 mmHg (65%), creatinine > 1.5 mg% (63%), bilirubin > 1.5 mg% (54%), noncontinuous-flow left ventricular assist devices (45%) for recipients and gender mismatch (81%) and ischemia time >4 hours (88%) for donors. Survival in recipient groups 1, 2, 3, 4, and 5 at 5 years was 81, 80, 77, 74, and 62%, respectively, and in donor groups 1, 2, and 3 at 5 years was 79, 77, and 70%, respectively (p transplanted with high-risk donor has acceptable survival at 5 years, but high-risk recipient combined with a high-risk donor has marginal results. Using an objective scoring system could help get the best results when utilizing high-risk donors. PMID:26771395

  2. Proposal for a New Prognostic Score for Linac-Based Radiosurgery in Cerebral Arteriovenous Malformations

    International Nuclear Information System (INIS)

    Purpose: We evaluate patient-, angioma-, and treatment-specific factors for successful obliteration of cerebral arteriovenous malformations (AVM) to develop a new appropriate score to predict patient outcome after linac-based radiosurgery (RS). Methods and Materials: This analysis in based on 293 patients with cerebral AVM. Mean age at treatment was 38.8 years (4–73 years). AVM classification according Spetzler-Martin was 55 patients Grade I (20.5%), 114 Grade II (42.5%), 79 Grade III (29.5%), 19 Grade IV (7.1%), and 1 Grade V (0.4%). Median maximum AVM diameter was 3.0 cm (range, 0.3–10 cm). Median dose prescribed to the 80% isodose was 18 Gy (range, 12–22 Gy). Eighty-five patients (29.1%) had prior partial embolization; 141 patients (51.9%) experienced intracranial hemorrhage before RS. Median follow-up was 4.2 years. Results: Age at treatment, maximum diameter, nidus volume, and applied dose were significant factors for successful obliteration. Under presumption of proportional hazard in the dose range between 12 and 22 Gy/80% isodose, an increase of obliteration rate of approximately 25% per Gy was seen. On the basis of multivariate analysis, a prediction score was calculated including AVM maximum diameter and age at treatment. The prediction error up to the time point 8 years was 0.173 for the Heidelberg score compared with the Kaplan-Meier value of 0.192. An increase of the score of 1 point results in a decrease of obliteration chance by a factor of 0.447. Conclusion: The proposed score is linac-based radiosurgery–specific and easy to handle to predict patient outcome. Further validation on an independent patient cohort is necessary.

  3. The effects of calculator-based laboratories on standardized test scores

    Science.gov (United States)

    Stevens, Charlotte Bethany Rains

    Nationwide, the goal of providing a productive science and math education to our youth in today's educational institutions is centering itself around the technology being utilized in these classrooms. In this age of digital technology, educational software and calculator-based laboratories (CBL) have become significant devices in the teaching of science and math for many states across the United States. Among the technology, the Texas Instruments graphing calculator and Vernier Labpro interface, are among some of the calculator-based laboratories becoming increasingly popular among middle and high school science and math teachers in many school districts across this country. In Tennessee, however, it is reported that this type of technology is not regularly utilized at the student level in most high school science classrooms, especially in the area of Physical Science (Vernier, 2006). This research explored the effect of calculator based laboratory instruction on standardized test scores. The purpose of this study was to determine the effect of traditional teaching methods versus graphing calculator teaching methods on the state mandated End-of-Course (EOC) Physical Science exam based on ability, gender, and ethnicity. The sample included 187 total tenth and eleventh grade physical science students, 101 of which belonged to a control group and 87 of which belonged to the experimental group. Physical Science End-of-Course scores obtained from the Tennessee Department of Education during the spring of 2005 and the spring of 2006 were used to examine the hypotheses. The findings of this research study suggested the type of teaching method, traditional or calculator based, did not have an effect on standardized test scores. However, the students' ability level, as demonstrated on the End-of-Course test, had a significant effect on End-of-Course test scores. This study focused on a limited population of high school physical science students in the middle Tennessee

  4. Gene expression-based risk score in diffuse large B-cell lymphoma.

    OpenAIRE

    Bret, Caroline; Klein, Bernard; Moreaux, Jérôme

    2012-01-01

    International audience Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma and displays heterogeneous clinical and molecular characteristics. In this study, high throughput gene expression profiling of DLBCL tumor samples was used to design a 12-gene expression-based risk score (GERS) predictive for patient's overall survival. GERS allowed identifying a high-risk group comprising 46,4% of the DLBCL patients in two independent cohorts (n=414 and n=69). GERS...

  5. Score Correlation

    OpenAIRE

    Fabián, Z. (Zdeněk)

    2010-01-01

    In this paper, we study a distribution-dependent correlation coefficient based on the concept of scalar score. This new measure of association of continuous random variables is compared by means of simulation experiments with the Pearson, Kendall and Spearman correlation coefficients.

  6. Query Performance Prediction for Information Retrieval Based on Covering Topic Score

    Institute of Scientific and Technical Information of China (English)

    Hao Lang; Bin Wang; Gareth Jones; Jin-Tao Li; Fan Ding; Yi-Xuan Liu

    2008-01-01

    We present a statistical method called Covering Topic Score (CTS) to predict query performance for information retrieval. Estimation is based on how well the topic of a user's query is covered by documents retrieved from a certain retrieval system. Our approach is conceptually simple and intuitive, and can be easily extended to incorporate features beyond bag-of-words such as phrases and proximity of terms. Experiments demonstrate that CTS significantly correlates with query performance in a variety of TREC test collections, and in particular CTS gains more prediction power benefiting from features of phrases and proximity of terms. We compare CTS with previous state-of-the-art methods for query performance prediction including clarity score and robustness score. Our experimental results show that CTS consistently performs better than, or at least as well as, these other methods. In addition to its high effectiveness, CTS is also shown to have very low computational complexity, meaning that it can be practical for real applications.

  7. An Interval-Valued Intuitionistic Fuzzy TOPSIS Method Based on an Improved Score Function

    Directory of Open Access Journals (Sweden)

    Zhi-yong Bai

    2013-01-01

    Full Text Available This paper proposes an improved score function for the effective ranking order of interval-valued intuitionistic fuzzy sets (IVIFSs and an interval-valued intuitionistic fuzzy TOPSIS method based on the score function to solve multicriteria decision-making problems in which all the preference information provided by decision-makers is expressed as interval-valued intuitionistic fuzzy decision matrices where each of the elements is characterized by IVIFS value and the information about criterion weights is known. We apply the proposed score function to calculate the separation measures of each alternative from the positive and negative ideal solutions to determine the relative closeness coefficients. According to the values of the closeness coefficients, the alternatives can be ranked and the most desirable one(s can be selected in the decision-making process. Finally, two illustrative examples for multicriteria fuzzy decision-making problems of alternatives are used as a demonstration of the applications and the effectiveness of the proposed decision-making method.

  8. Scoring predictive models using a reduced representation of proteins: model and energy definition

    Directory of Open Access Journals (Sweden)

    Corazza Alessandra

    2007-03-01

    Full Text Available Abstract Background Reduced representations of proteins have been playing a keyrole in the study of protein folding. Many such models are available, with different representation detail. Although the usefulness of many such models for structural bioinformatics applications has been demonstrated in recent years, there are few intermediate resolution models endowed with an energy model capable, for instance, of detecting native or native-like structures among decoy sets. The aim of the present work is to provide a discrete empirical potential for a reduced protein model termed here PC2CA, because it employs a PseudoCovalent structure with only 2 Centers of interactions per Amino acid, suitable for protein model quality assessment. Results All protein structures in the set top500H have been converted in reduced form. The distribution of pseudobonds, pseudoangle, pseudodihedrals and distances between centers of interactions have been converted into potentials of mean force. A suitable reference distribution has been defined for non-bonded interactions which takes into account excluded volume effects and protein finite size. The correlation between adjacent main chain pseudodihedrals has been converted in an additional energetic term which is able to account for cooperative effects in secondary structure elements. Local energy surface exploration is performed in order to increase the robustness of the energy function. Conclusion The model and the energy definition proposed have been tested on all the multiple decoys' sets in the Decoys'R'us database. The energetic model is able to recognize, for almost all sets, native-like structures (RMSD less than 2.0 Å. These results and those obtained in the blind CASP7 quality assessment experiment suggest that the model compares well with scoring potentials with finer granularity and could be useful for fast exploration of conformational space. Parameters are available at the url: http://www.dstb.uniud.it/~ffogolari/download/.

  9. Towards an Evidence Based Score Card for Aligning Risk Management and Sustainability Goals for Essential NORM Industries: Case Study - Phosphates

    International Nuclear Information System (INIS)

    Approaches to regulating NORM industries risk suffering blight from over-conservative methodologies, whether based on worst case models, extreme event scenarios or unmediated application of the precautionary principle: the outcome can be a significant overestimation of risk and a consequent penalty on both producers and consumers in terms of access to and affordability of the intermediate and end products those industries provide. In particular, for historical reasons derived perhaps from the potentially distracting regulatory focus on what is usually trace radioactivity in products and by-products containing NORM, there is a damaging tendency to seek risk management models and best practices from nuclear industries in general rather than from those sectors to which the end products of NORM industries are specifically aligned. This risk is particularly visible in the phosphate sector, an industry now pivotal to long term security and sustainability in both food production and energy supply, plant based or nuclear. Premised on a companion paper which sets out the theory of 'constructive regulation', presented in 2008 at the 12th International Congress of the International Radiation Protection Association, Buenos Aires, this paper proposes the use of an evidence based score carding system to ensure the future alignment of risk management and sustainability goals for NORM industries, starting with phosphates. The score card elements are broken out into three primary categories along the lines defined in the concept of triple bottom line performance measurement, comprising economic, social and environmental elements. The question is put as to what role constructive regulation and best practices can play in ensuring that the outcome of the regulatory process is the preservation and enhancement of the capability of these industries to deliver sustainable returns to the customers and stakeholders who depend on them. Score carding will facilitate transparent, objective

  10. Electrocardiogram-based scoring system for predicting secondary pulmonary hypertension: A cross-sectional study

    OpenAIRE

    Pancholy, Samir Bipin; Palamaner Subash Shantha, Ghanshyam; Patel, Nimesh Kirit; Boruah, Pranjal; Nanavaty, Sukrut; Chandran, Sindu; Sethi, Arjinder; Sheth, Jignesh

    2014-01-01

    Objectives In this study, we have developed an electrocardiogram-based scoring system to predict secondary pulmonary hypertension. Design A cross-sectional study. Setting Single tertiary-care hospital in Scranton, Pennsylvania, USA. Participants Five hundred and fifty-two consecutive patients undergoing right heart catheterization between 2006 and 2009. Main outcome measures Surface electrocardiogram was assessed for R-wave in lead V1 ≥ 6mm, R-wave in V6 ≤ 3mm, S-wave in V6 ≥ 3mm, right atria...

  11. Team-based learning on a third-year pediatric clerkship improves NBME subject exam blood disorder scores

    Directory of Open Access Journals (Sweden)

    Kris Saudek

    2015-10-01

    Full Text Available Purpose: At our institution, speculation amongst medical students and faculty exists as to whether team-based learning (TBL can improve scores on high-stakes examinations over traditional didactic lectures. Faculty with experience using TBL developed and piloted a required TBL blood disorders (BD module for third-year medical students on their pediatric clerkship. The purpose of this study is to analyze the BD scores from the NBME subject exams before and after the introduction of the module. Methods: We analyzed institutional and national item difficulties for BD items from the NBME pediatrics content area item analysis reports from 2011 to 2014 before (pre and after (post the pilot (October 2012. Total scores of 590 NBME subject examination students from examinee performance profiles were analyzed pre/post. t-Tests and Cohen's d effect sizes were used to analyze item difficulties for institutional versus national scores and pre/post comparisons of item difficulties and total scores. Results: BD scores for our institution were 0.65 (±0.19 compared to 0.62 (±0.15 nationally (P=0.346; Cohen's d=0.15. The average of post-consecutive BD scores for our students was 0.70(±0.21 compared to examinees nationally [0.64 (±0.15] with a significant mean difference (P=0.031; Cohen's d=0.43. The difference in our institutions pre [0.65 (±0.19] and post [0.70 (±0.21] BD scores trended higher (P=0.391; Cohen's d=0.27. Institutional BD scores were higher than national BD scores for both pre and post, with an effect size that tripled from pre to post scores. Institutional BD scores increased after the use of the TBL module, while overall exam scores remained steadily above national norms. Conclusions: Institutional BD scores were higher than national BD scores for both pre and post, with an effect size that tripled from pre to post scores. Institutional BD scores increased after the use of the TBL module, while overall exam scores remained steadily above

  12. Team-based learning on a third-year pediatric clerkship improves NBME subject exam blood disorder scores

    Science.gov (United States)

    Saudek, Kris; Treat, Robert

    2015-01-01

    Purpose At our institution, speculation amongst medical students and faculty exists as to whether team-based learning (TBL) can improve scores on high-stakes examinations over traditional didactic lectures. Faculty with experience using TBL developed and piloted a required TBL blood disorders (BD) module for third-year medical students on their pediatric clerkship. The purpose of this study is to analyze the BD scores from the NBME subject exams before and after the introduction of the module. Methods We analyzed institutional and national item difficulties for BD items from the NBME pediatrics content area item analysis reports from 2011 to 2014 before (pre) and after (post) the pilot (October 2012). Total scores of 590 NBME subject examination students from examinee performance profiles were analyzed pre/post. t-Tests and Cohen's d effect sizes were used to analyze item difficulties for institutional versus national scores and pre/post comparisons of item difficulties and total scores. Results BD scores for our institution were 0.65 (±0.19) compared to 0.62 (±0.15) nationally (P=0.346; Cohen's d=0.15). The average of post-consecutive BD scores for our students was 0.70 (±0.21) compared to examinees nationally [0.64 (±0.15)] with a significant mean difference (P=0.031; Cohen's d=0.43). The difference in our institutions pre [0.65 (±0.19)] and post [0.70 (±0.21)] BD scores trended higher (P=0.391; Cohen's d=0.27). Institutional BD scores were higher than national BD scores for both pre and post, with an effect size that tripled from pre to post scores. Institutional BD scores increased after the use of the TBL module, while overall exam scores remained steadily above national norms. Conclusions Institutional BD scores were higher than national BD scores for both pre and post, with an effect size that tripled from pre to post scores. Institutional BD scores increased after the use of the TBL module, while overall exam scores remained steadily above national

  13. Analysis of WHO-Based Prognostic Scoring System (WPSS) of Myelodysplastic Syndrome and Its Comparison with International Prognostic Scoring System (IPSS) in 100 Chinese Patients

    Institute of Scientific and Technical Information of China (English)

    Jia Wei; Xiao-fen Zhou; Jian-feng Zhou; Yan Chen

    2009-01-01

    Objective: The aims of this study were to assess the prognostic significance of WHO-based Prognostic Scoring System (WPSS) in myelodysplastic syndrome (MDS) from a single center institute and to compare WPSS with the international prognostic scoring system (IPSS).Methods: A total of 100 cases with de novo MDS were reviewed and their karyotypes were detected. All of them were followed up and classified according to IPSS and WPSS risk groups. SPSS 13.0 software was applied to deal with all the data. The statistical methods included Kaplan - Meier, Log-rank test and cox regression.Results: Multivariate cox regression analysis indicated that WHO Classification (P=0.0190), karyotype abnormalities categorized according to IPSS (P=0.0159) and red blood cell (RBC) transfusion (P=0.0009) were the three most important independent factors for predicting overall survival (OS) of MDS. WPSS and IPSS both had great capacity in predicting the OS of MDS at the time of diagnosis (P<0.0001). In time-dependent analysis, WPSS can predict the OS accurately in the following three years after diagnosis (P<0.0001), while IPSS failed to predict the OS 24 months after diagnosis (P=0.1094).Conclusion: Our single center results proved that WPSS is a dynamic prognostic system which can predict the OS of MDS patients at any time during the course of their disease. This time-dependent prognostic scoring system may replace the IPSS in the near future.

  14. Image Analysis-Based Approaches for Scoring Mouse Models of Colitis.

    Science.gov (United States)

    Rogers, R; Eastham-Anderson, J; DeVoss, J; Lesch, J; Yan, D; Xu, M; Solon, M; Hotzel, K; Diehl, L; Webster, J D

    2016-01-01

    Mouse models of inflammatory bowel disease are critical for basic and translational research that is advancing the understanding and treatment of this disease. Assessment of these mouse models frequently relies on histologic endpoints. In recent years, whole slide imaging and digital pathology-based image analysis platforms have become increasingly available for implementation into the pathology workflow. These automated image analysis approaches allow for nonbiased quantitative assessment of histologic endpoints. In this study, the authors sought to develop an image analysis workflow using a commercially available image analysis platform that requires minimal training in image analysis or programming, and this workflow was used to score 2 mouse models of colitis that are primarily characterized by immune cell infiltrates in the lamina propria. Although the software was unable to accurately and consistently segment hematoxylin and eosin-stained sections, automated quantification of CD3 immunolabeling resulted in strong correlations with the pathologist's score in all studies and allowed for the identification of 8 of the 9 differences among treatment groups that were identified by the pathologist. These results demonstrate not only the ability to incorporate solutions based on image analysis into the pathologist's workflow but also the importance of immunohistochemical or histochemical surrogates for the incorporation of image analysis in histologic assessments. PMID:25907770

  15. A Validity-Based Approach to Quality Control and Assurance of Automated Scoring

    Science.gov (United States)

    Bejar, Isaac I.

    2011-01-01

    Automated scoring of constructed responses is already operational in several testing programmes. However, as the methodology matures and the demand for the utilisation of constructed responses increases, the volume of automated scoring is likely to increase at a fast pace. Quality assurance and control of the scoring process will likely be more…

  16. Apgar Scores

    Science.gov (United States)

    ... are more likely to have low scores than infants with normal births. These scores may reflect difficulties the baby experienced during labor or problems with her heart or respiratory system. What if Your Baby Scores Low? If your ...

  17. Sequence-based genotyping for marker discovery and co-dominant scoring in germplasm and populations.

    Science.gov (United States)

    Truong, Hoa T; Ramos, A Marcos; Yalcin, Feyruz; de Ruiter, Marjo; van der Poel, Hein J A; Huvenaars, Koen H J; Hogers, René C J; van Enckevort, Leonora J G; Janssen, Antoine; van Orsouw, Nathalie J; van Eijk, Michiel J T

    2012-01-01

    Conventional marker-based genotyping platforms are widely available, but not without their limitations. In this context, we developed Sequence-Based Genotyping (SBG), a technology for simultaneous marker discovery and co-dominant scoring, using next-generation sequencing. SBG offers users several advantages including a generic sample preparation method, a highly robust genome complexity reduction strategy to facilitate de novo marker discovery across entire genomes, and a uniform bioinformatics workflow strategy to achieve genotyping goals tailored to individual species, regardless of the availability of a reference sequence. The most distinguishing features of this technology are the ability to genotype any population structure, regardless whether parental data is included, and the ability to co-dominantly score SNP markers segregating in populations. To demonstrate the capabilities of SBG, we performed marker discovery and genotyping in Arabidopsis thaliana and lettuce, two plant species of diverse genetic complexity and backgrounds. Initially we obtained 1,409 SNPs for arabidopsis, and 5,583 SNPs for lettuce. Further filtering of the SNP dataset produced over 1,000 high quality SNP markers for each species. We obtained a genotyping rate of 201.2 genotypes/SNP and 58.3 genotypes/SNP for arabidopsis (n = 222 samples) and lettuce (n = 87 samples), respectively. Linkage mapping using these SNPs resulted in stable map configurations. We have therefore shown that the SBG approach presented provides users with the utmost flexibility in garnering high quality markers that can be directly used for genotyping and downstream applications. Until advances and costs will allow for routine whole-genome sequencing of populations, we expect that sequence-based genotyping technologies such as SBG will be essential for genotyping of model and non-model genomes alike. PMID:22662172

  18. Use of metabolic profiles and body condition scoring for the assessment of energy status of dairy cows

    OpenAIRE

    Prodanović R.; Sladojević Ž.; Kirovski D.; Vujanac I.; Ivetić V.; Savić B.; Kureljušić B.; Stevančević M.

    2012-01-01

    The aim of this study was to assess the significance of body condition scoring and metabolic profile test for estimation of energy status of healthy high-yielding dairy cows. Twenty one healthy cows (primiparous and secundiparous) were divided into three groups: dry cows, early puerperal cows and early lactating cows. Cow’s energy status was estimated by the analysis of blood samples for beta-hydroxybutirate (BHBA) and glucose. Additionally, urea, total bil...

  19. CT-based abdominal aortic calcification score as a surrogate marker for predicting the presence of asymptomatic coronary artery disease

    International Nuclear Information System (INIS)

    To assess the value of a CT-based abdominal aortic calcification (AAC) score as a surrogate marker for the presence of asymptomatic coronary artery disease (CAD). The AAC scores of 373 patients without cardiac symptoms who underwent both screening coronary CT angiography and abdominal CT within one year were calculated according to the Agatston method. Logistic regression was used to derive two multivariate models from traditional cardiovascular risk factors, with and without AAC scores, to predict the presence of CAD. The AAC score and the two multivariate models were compared by calculating the area under the receiver operating characteristic curve (AUC) and the net reclassification improvement (NRI). The AAC score alone showed a marginally higher AUC (0.823 vs. 0.767, P = 0.061) and significantly better risk classification (NRI = 0.158, P = 0.048) than the multivariate model without AAC. The multivariate model using traditional factors and AAC did not show a significantly higher AUC (0.832 vs. 0.823, P = 0.616) or NRI (0.073, P = 0.13) than the AAC score alone. The optimal cutoff value of the AAC score for predicting CAD was 1025.8 (sensitivity, 79.5 %; specificity, 75.9 %). AAC scores may serve as a surrogate marker for the presence or absence of asymptomatic CAD. (orig.)

  20. CT-based abdominal aortic calcification score as a surrogate marker for predicting the presence of asymptomatic coronary artery disease

    Energy Technology Data Exchange (ETDEWEB)

    An, Chansik; Lee, Hye-Jeong; Ahn, Sung Soo; Choi, Byoung Wook; Kim, Myeong-Jin; Chung, Yong Eun [Severance Hospital, Yonsei University College of Medicine, Department of Radiology, Research Institute of Radiological Science, 50 Yonsei-Ro, Seodaemun-Gu, Seoul (Korea, Republic of); Lee, Hye Sun [Yonsei University College of Medicine, Biostatistics Collaboration Unit, Department of Research Affairs, Seoul (Korea, Republic of)

    2014-10-15

    To assess the value of a CT-based abdominal aortic calcification (AAC) score as a surrogate marker for the presence of asymptomatic coronary artery disease (CAD). The AAC scores of 373 patients without cardiac symptoms who underwent both screening coronary CT angiography and abdominal CT within one year were calculated according to the Agatston method. Logistic regression was used to derive two multivariate models from traditional cardiovascular risk factors, with and without AAC scores, to predict the presence of CAD. The AAC score and the two multivariate models were compared by calculating the area under the receiver operating characteristic curve (AUC) and the net reclassification improvement (NRI). The AAC score alone showed a marginally higher AUC (0.823 vs. 0.767, P = 0.061) and significantly better risk classification (NRI = 0.158, P = 0.048) than the multivariate model without AAC. The multivariate model using traditional factors and AAC did not show a significantly higher AUC (0.832 vs. 0.823, P = 0.616) or NRI (0.073, P = 0.13) than the AAC score alone. The optimal cutoff value of the AAC score for predicting CAD was 1025.8 (sensitivity, 79.5 %; specificity, 75.9 %). AAC scores may serve as a surrogate marker for the presence or absence of asymptomatic CAD. (orig.)

  1. Evaluation of a novel scoring and grading model for VP-based exams in postgraduate nurse education.

    Science.gov (United States)

    Forsberg, Elenita; Ziegert, Kristina; Hult, Håkan; Fors, Uno

    2015-12-01

    For Virtual Patient-based exams, several scoring and grading methods have been proposed, but none have yet been validated. The aim of this study was to evaluate a new scoring and grading model for VP-based exams in postgraduate paediatric nurse education. The same student group of 19 students performed a VP-based exam in three consecutive courses. When using the scoring and grading assessment model, which contains a deduction system for unnecessary or unwanted actions, a progression was found in the three courses: 53% of the students passed the first exam, 63% the second and 84% passed the final exam. The most common reason for deduction of points was due to students asking too many interview questions or ordering too many laboratory tests. The results showed that the new scoring model made it possible to judge the students' clinical reasoning process as well as their progress. PMID:25979799

  2. Strategic Planning Model Formulation Based on Balanced Score Card: A Case Study

    Directory of Open Access Journals (Sweden)

    Elaheh Enteshari Najaf Abadi

    2012-07-01

    Full Text Available At the present age, strategic planning is considered as an important and vital matter for organizations and formulating and implementing strategic plans and accurate parameters may result in organizations long-term superiority in competitive field. But, regarding that competitive factors of all organizations are not the same, formulating the strategy with a similar trend is unlikely to be effective and the prerequisite for success of any organization is to focus and pay attention to its own capacities and unique competitive advantages and to formulate strategies based on those capacities along with focusing on the weakness and threats points. This article presents a model integrated of the strategic planning process and balanced score card and considering four dimensions of the Balanced Score Card (BSC, it accomplishes the process of strategic planning in the fields of financial, customer, internal processes and growth and learning separately and then determines the position of an organization in each dimension. Therefore, the strength and weakness points of the organization are identified and the type of strategies needed for any dimension determined separately. With the aid of this model, top managers are able to determine the organization expects and goals of different sectors clearly and in line with the vision and strategy of organization and deliver to the managers and authorities of different sectors. The results of this model are the analysis of factors influencing on the strategy formulation, extraction of key dimensions, provision of the SWOT matrix for four-folds dimensions of BSC and the identification of organization situation in each dimension such that through basing it on, integrated strategies and operational plans will be formulated for the organization. In this survey, Isfahan Company of tile industry has been studied as a sample and the results of the model implementation for this company described in the text.

  3. Validity and predictive ability of the juvenile arthritis disease activity score based on CRP versus ESR in a Nordic population-based setting

    DEFF Research Database (Denmark)

    Nordal, E B; Zak, Marek Stanislaw; Aalto, K;

    2012-01-01

    To compare the juvenile arthritis disease activity score (JADAS) based on C reactive protein (CRP) (JADAS-CRP) with JADAS based on erythrocyte sedimentation rate (ESR) (JADAS-ESR) and to validate JADAS in a population-based setting.......To compare the juvenile arthritis disease activity score (JADAS) based on C reactive protein (CRP) (JADAS-CRP) with JADAS based on erythrocyte sedimentation rate (ESR) (JADAS-ESR) and to validate JADAS in a population-based setting....

  4. Dissecting complex transcriptional responses using pathway-level scores based on prior information

    Directory of Open Access Journals (Sweden)

    Ward Lucas D

    2007-09-01

    Full Text Available Abstract Background The genomewide pattern of changes in mRNA expression measured using DNA microarrays is typically a complex superposition of the response of multiple regulatory pathways to changes in the environment of the cells. The use of prior information, either about the function of the protein encoded by each gene, or about the physical interactions between regulatory factors and the sequences controlling its expression, has emerged as a powerful approach for dissecting complex transcriptional responses. Results We review two different approaches for combining the noisy expression levels of multiple individual genes into robust pathway-level differential expression scores. The first is based on a comparison between the distribution of expression levels of genes within a predefined gene set and those of all other genes in the genome. The second starts from an estimate of the strength of genomewide regulatory network connectivities based on sequence information or direct measurements of protein-DNA interactions, and uses regression analysis to estimate the activity of gene regulatory pathways. The statistical methods used are explained in detail. Conclusion By avoiding the thresholding of individual genes, pathway-level analysis of differential expression based on prior information can be considerably more sensitive to subtle changes in gene expression than gene-level analysis. The methods are technically straightforward and yield results that are easily interpretable, both biologically and statistically.

  5. Correlation Between An Email Based Board Review Program and American Board of Pediatrics General Pediatrics Certifying Examination Scores

    OpenAIRE

    Langenau, Erik E.; Fogel, Joshua; Schaeffer, Henry A.

    2009-01-01

    Objective To investigate the impact of a weekly email based board review course on individual resident performance on the American Board of Pediatrics (ABP) General Pediatrics Certifying Examination for pediatric residents and, specifically, residents with low ABP In-training Examination (ITE) scores. Methods Weekly board-type questions were emailed to all pediatric residents from 2004–2007. Responses to board-type questions were tracked, recorded, and correlated with ITE scores and ABP Gener...

  6. Correlation Between An Email Based Board Review Program and American Board of Pediatrics General Pediatrics Certifying Examination Scores

    OpenAIRE

    Langenau, Erik E.; Fogel, Joshua; Schaeffer, Henry A.

    2009-01-01

    Objective: To investigate the impact of a weekly email based board review course on individual resident performance on the American Board of Pediatrics (ABP) General Pediatrics Certifying Examination for pediatric residents and, specifically, residents with low ABP In-training Examination (ITE) scores. Methods: Weekly board-type questions were emailed to all pediatric residents from 2004_2007. Responses to board-type questions were tracked, recorded, and correlated with ITE scores and ABP Gen...

  7. Advanced Taste Sensors Based on Artificial Lipids with Global Selectivity to Basic Taste Qualities and High Correlation to Sensory Scores

    OpenAIRE

    Yoshikazu Kobayashi; Masaaki Habara; Hidekazu Ikezazki; Ronggang Chen; Yoshinobu Naito; Kiyoshi Toko

    2010-01-01

    Effective R&D and strict quality control of a broad range of foods, beverages, and pharmaceutical products require objective taste evaluation. Advanced taste sensors using artificial-lipid membranes have been developed based on concepts of global selectivity and high correlation with human sensory score. These sensors respond similarly to similar basic tastes, which they quantify with high correlations to sensory score. Using these unique properties, these sensors can quantify the basic t...

  8. Estimation of synthetic accessibility score of drug-like molecules based on molecular complexity and fragment contributions

    OpenAIRE

    Ertl Peter; Schuffenhauer Ansgar

    2009-01-01

    Abstract Background A method to estimate ease of synthesis (synthetic accessibility) of drug-like molecules is needed in many areas of the drug discovery process. The development and validation of such a method that is able to characterize molecule synthetic accessibility as a score between 1 (easy to make) and 10 (very difficult to make) is described in this article. Results The method for estimation of the synthetic accessibility score (SAscore) described here is based on a combination of f...

  9. Team-based learning on a third-year pediatric clerkship improves NBME subject exam blood disorder scores

    OpenAIRE

    Saudek, Kris; Treat, Robert

    2015-01-01

    Purpose: At our institution, speculation amongst medical students and faculty exists as to whether team-based learning (TBL) can improve scores on high-stakes examinations over traditional didactic lectures. Faculty with experience using TBL developed and piloted a required TBL blood disorders (BD) module for third-year medical students on their pediatric clerkship. The purpose of this study is to analyze the BD scores from the NBME subject exams before and after the introduction of the modul...

  10. The Impact of Different Scoring Rubrics for Grading Virtual Patient-Based Exams

    Science.gov (United States)

    Fors, Uno G. H.; Gunning, William T.

    2014-01-01

    Virtual patient cases (VPs) are used for healthcare education and assessment. Most VP systems track user interactions to be used for assessment. Few studies have investigated how virtual exam cases should be scored and graded. We have applied eight different scoring models on a data set from 154 students. Issues studied included the impact of…

  11. Speed-Accuracy Response Models: Scoring Rules Based on Response Time and Accuracy

    Science.gov (United States)

    Maris, Gunter; van der Maas, Han

    2012-01-01

    Starting from an explicit scoring rule for time limit tasks incorporating both response time and accuracy, and a definite trade-off between speed and accuracy, a response model is derived. Since the scoring rule is interpreted as a sufficient statistic, the model belongs to the exponential family. The various marginal and conditional distributions…

  12. Fuzzy weighted average based on left and right scores in Malaysia tourism industry

    Science.gov (United States)

    Kamis, Nor Hanimah; Abdullah, Kamilah; Zulkifli, Muhammad Hazim; Sahlan, Shahrazali; Mohd Yunus, Syaizzal

    2013-04-01

    Tourism is known as an important sector to the Malaysian economy including economic generator, creating business and job offers. It is reported to bring in almost RM30 billion of the national income, thanks to intense worldwide promotion by Tourism Malaysia. One of the well-known attractions in Malaysia is our beautiful islands. The islands continue to be developed into tourist spots and attracting a continuous number of tourists. Chalets, luxury bungalows and resorts quickly develop along the coastlines of popular islands like Tioman, Redang, Pangkor, Perhentian, Sibu and so many others. In this study, we applied Fuzzy Weighted Average (FWA) method based on left and right scores in order to determine the criteria weights and to select the best island in Malaysia. Cost, safety, attractive activities, accommodation and scenery are five main criteria to be considered and five selected islands in Malaysia are taken into accounts as alternatives. The most important criteria that have been considered by the tourist are defined based on criteria weights ranking order and the best island in Malaysia is then determined in terms of FWA values. This pilot study can be used as a reference to evaluate performances or solving any selection problems, where more criteria, alternatives and decision makers will be considered in the future.

  13. Prediction of 18-month survival in patients with primary myelodysplastic syndrome. A regression model and scoring system based on the combination of chromosome findings and the Bournemouth score.

    Science.gov (United States)

    Parlier, V; van Melle, G; Beris, P; Schmidt, P M; Tobler, A; Haller, E; Bellomo, M J

    1995-06-01

    The predictive potential of six selected factors was assessed in 72 patients with primary myelodysplastic syndrome using univariate and multivariate logistic regression analysis of survival at 18 months. Factors were age (above median of 69 years), dysplastic features in the three myeloid bone marrow cell lineages, presence of chromosome defects, all metaphases abnormal, double or complex chromosome defects (C23), and a Bournemouth score of 2, 3, or 4 (B234). In the multivariate approach, B234 and C23 proved to be significantly associated with a reduction in the survival probability. The similarity of the regression coefficients associated with these two factors means that they have about the same weight. Consequently, the model was simplified by counting the number of factors (0, 1, or 2) present in each patient, thus generating a scoring system called the Lausanne-Bournemouth score (LB score). The LB score combines the well-recognized and easy-to-use Bournemouth score (B score) with the chromosome defect complexity, C23 constituting an additional indicator of patient outcome. The predicted risk of death within 18 months calculated from the model is as follows: 7.1% (confidence interval: 1.7-24.8) for patients with an LB score of 0, 60.1% (44.7-73.8) for an LB score of 1, and 96.8% (84.5-99.4) for an LB score of 2. The scoring system presented here has several interesting features. The LB score may improve the predictive value of the B score, as it is able to recognize two prognostic groups in the intermediate risk category of patients with B scores of 2 or 3. It has also the ability to identify two distinct prognostic subclasses among RAEB and possibly CMML patients. In addition to its above-described usefulness in the prognostic evaluation, the LB score may bring new insights into the understanding of evolution patterns in MDS. We used the combination of the B score and chromosome complexity to define four classes which may be considered four possible states of

  14. Progress Scored by CAS in Fuel Cell Engine and Hydrogen Energy Technology

    Institute of Scientific and Technical Information of China (English)

    Zhang Huamin

    2004-01-01

    @@ The fuel cell is an energy conversion device, in which the energy stored in fuel and oxidant is transformed into electricity and heat energy via electrochemical reactions. It has the advantage of high energy transform efficiency, low noise and environmental friendliness. It can also achieve energy supply diversity.

  15. An acoustic feature-based similarity scoring system for speech rehabilitation assistance.

    Science.gov (United States)

    Syauqy, Dahnial; Wu, Chao-Min; Setyawati, Onny

    2016-08-01

    The purpose of this study is to develop a tool to assist speech therapy and rehabilitation, which focused on automatic scoring based on the comparison of the patient's speech with another normal speech on several aspects including pitch, vowel, voiced-unvoiced segments, strident fricative and sound intensity. The pitch estimation employed the use of cepstrum-based algorithm for its robustness; the vowel classification used multilayer perceptron (MLP) to classify vowel from pitch and formants; and the strident fricative detection was based on the major peak spectral intensity, location and the pitch existence in the segment. In order to evaluate the performance of the system, this study analyzed eight patient's speech recordings (four males, four females; 4-58-years-old), which had been recorded in previous study in cooperation with Taipei Veterans General Hospital and Taoyuan General Hospital. The experiment result on pitch algorithm showed that the cepstrum method had 5.3% of gross pitch error from a total of 2086 frames. On the vowel classification algorithm, MLP method provided 93% accuracy (men), 87% (women) and 84% (children). In total, the overall results showed that 156 tool's grading results (81%) were consistent compared to 192 audio and visual observations done by four experienced respondents. Implication for Rehabilitation Difficulties in communication may limit the ability of a person to transfer and exchange information. The fact that speech is one of the primary means of communication has encouraged the needs of speech diagnosis and rehabilitation. The advances of technology in computer-assisted speech therapy (CAST) improve the quality, time efficiency of the diagnosis and treatment of the disorders. The present study attempted to develop tool to assist speech therapy and rehabilitation, which provided simple interface to let the assessment be done even by the patient himself without the need of particular knowledge of speech processing while at the

  16. Status of the ground-based wide-angle gamma-ray and cosmic-ray experiment SCORE

    International Nuclear Information System (INIS)

    We propose to explore the so-far poorly measured cosmic ray and gamma-ray sky (accelerator sky) in the energy range from 10 TeV to 1 EeV. The main motivation for observations in this energy regime is to solve the origin of Galactic cosmic rays. However, also fundamental questions of astroparticle physics and particle physics can be addressed and new physics questions might arise in the last remaining observation window of gamma-ray astronomy. The new large-area (10 square-km) wide-angle (1 sr) air Cherenkov detector SCORE (Study for a Cosmic Origin Explorer) is based on non-imaging Cherenkov light-front sampling with sensitive large-area detector modules of the order of 1 square-m. The lateral photon density and arrival-time distribution will be sampled up to large distances from the shower core. The physics motivations, the detector concept, the expected performance and the current status of the experiment are presented.

  17. Generalization of the Lord-Wingersky Algorithm to Computing the Distribution of Summed Test Scores Based on Real-Number Item Scores

    Science.gov (United States)

    Kim, Seonghoon

    2013-01-01

    With known item response theory (IRT) item parameters, Lord and Wingersky provided a recursive algorithm for computing the conditional frequency distribution of number-correct test scores, given proficiency. This article presents a generalized algorithm for computing the conditional distribution of summed test scores involving real-number item…

  18. Increased correlation coefficient between the written test score and tutors' performance test scores after training of tutors for assessment of medical students during problem-based learning course in Malaysia.

    Science.gov (United States)

    Jaiprakash, Heethal; Min, Aung Ko Ko; Ghosh, Sarmishtha

    2016-03-01

    This paper is aimed at finding if there was a change of correlation between the written test score and tutors' performance test scores in the assessment of medical students during a problem-based learning (PBL) course in Malaysia. This is a cross-sectional observational study, conducted among 264 medical students in two groups from November 2010 to November 2012. The first group's tutors did not receive tutor training; while the second group's tutors were trained in the PBL process. Each group was divided into high, middle and low achievers based on their end-of-semester exam scores. PBL scores were taken which included written test scores and tutors' performance test scores. Pearson correlation coefficient was calculated between the two kinds of scores in each group. The correlation coefficient between the written scores and tutors' scores in group 1 was 0.099 (p<0.001) and for group 2 was 0.305 (p<0.001). The higher correlation coefficient in the group where tutors received the PBL training reinforces the importance of tutor training before their participation in the PBL course. PMID:26838577

  19. Hospital Value-Based Purchasing (HVBP) – Efficiency Scores

    Data.gov (United States)

    U.S. Department of Health & Human Services — A list of hospitals participating in the Hospital VBP Program and their performance ratios and scores for the Efficiency Medicare Spending per Beneficiary (MSPB)...

  20. Hospital Value-Based Purchasing (HVBP) – Pneumonia Scores

    Data.gov (United States)

    U.S. Department of Health & Human Services — A list of hospitals participating in the Hospital VBP Program and their performance rates and scores for the Clinical Process of Care Pneumonia measures.

  1. A comparative assessment of non-laboratory-based versus commonly used laboratory-based cardiovascular disease risk scores in the NHANES III population.

    Directory of Open Access Journals (Sweden)

    Ankur Pandya

    Full Text Available BACKGROUND: National and international primary CVD risk screening guidelines focus on using total CVD risk scores. Recently, we developed a non-laboratory-based CVD risk score (inputs: age, sex, smoking, diabetes, systolic blood pressure, treatment of hypertension, body-mass index, which can assess risk faster and at lower costs compared to laboratory-based scores (inputs include cholesterol values. We aimed to assess the exchangeability of the non-laboratory-based risk score to four commonly used laboratory-based scores (Framingham CVD [2008, 1991 versions], and Systematic COronary Risk Evaluation [SCORE] for low and high risk settings in an external validation population. METHODS AND FINDINGS: Analyses were based on individual-level, score-specific rankings of risk for adults in the Third National Health and Nutrition Examination Survey (NHANES III aged 25-74 years, without history of CVD or cancer (n = 5,999. Risk characterization agreement was based on overlap in dichotomous risk characterization (thresholds of 10-year risk >10-20% and Spearman rank correlation. Risk discrimination was assessed using receiver operator characteristic curve analysis (10-year CVD death outcome. Risk characterization agreement ranged from 91.9-95.7% and 94.2-95.1% with Spearman correlation ranges of 0.957-0.980 and 0.946-0.970 for men and women, respectively. In men, c-statistics for the non-laboratory-based, Framingham (2008, 1991, and SCORE (high, low functions were 0.782, 0.776, 0.781, 0.785, and 0.785, with p-values for differences relative to the non-laboratory-based score of 0.44, 0.89, 0.68 and 0.65, respectively. In women, the corresponding c-statistics were 0.809, 0.834, 0.821, 0.792, and 0.792, with corresponding p-values of 0.04, 0.34, 0.11 and 0.09, respectively. CONCLUSIONS: Every score discriminated risk of CVD death well, and there was high agreement in risk characterization between non-laboratory-based and laboratory-based risk scores, which

  2. Life in Triviality:Reinterpretation of The Hours Based on Philip Glass’Scores

    Institute of Scientific and Technical Information of China (English)

    王聿兮

    2015-01-01

    The movie The Hours, adapted from Michael Cunningham’s novel, presents us three different women’s life in a day to reflect trivial people’s struggle, contemplation of self-worth and death, with Philip Glass’scores and the well-designed set⁃tings. This paper focuses on Glass’scores and analyzes its connection with other elements, reflection of those people and coher⁃ence of the movie.

  3. Measurement Properties of the Smartphone-Based B-B Score in Current Shoulder Pathologies

    Directory of Open Access Journals (Sweden)

    Claude Pichonnaz

    2015-10-01

    Full Text Available This study is aimed at the determination of the measurement properties of the shoulder function B-B Score measured with a smartphone. This score measures the symmetry between sides of a power-related metric for two selected movements, with 100% representing perfect symmetry. Twenty healthy participants, 20 patients with rotator cuff conditions, 23 with fractures, 22 with capsulitis, and 23 with shoulder instabilities were measured twice across a six-month interval using the B-B Score and shoulder function questionnaires. The discriminative power, responsiveness, diagnostic power, concurrent validity, minimal detectable change (MDC, minimal clinically important improvement (MCII, and patient acceptable symptom state (PASS were evaluated. Significant differences with the control group and significant baseline—six-month differences were found for the rotator cuff condition, fracture, and capsulitis patient groups. The B-B Score was responsive and demonstrated excellent diagnostic power, except for shoulder instability. The correlations with clinical scores were generally moderate to high, but lower for instability. The MDC was 18.1%, the MCII was 25.2%, and the PASS was 77.6. No floor effect was observed. The B-B Score demonstrated excellent measurement properties in populations with rotator cuff conditions, proximal humerus fractures, and capsulitis, and can thus be used as a routine test to evaluate those patients.

  4. Investigating the importance of Delaunay-based definition of atomic interactions in scoring of protein-protein docking results.

    Science.gov (United States)

    Jafari, Rahim; Sadeghi, Mehdi; Mirzaie, Mehdi

    2016-05-01

    The approaches taken to represent and describe structural features of the macromolecules are of major importance when developing computational methods for studying and predicting their structures and interactions. This study attempts to explore the significance of Delaunay tessellation for the definition of atomic interactions by evaluating its impact on the performance of scoring protein-protein docking prediction. Two sets of knowledge-based scoring potentials are extracted from a training dataset of native protein-protein complexes. The potential of the first set is derived using atomic interactions extracted from Delaunay tessellated structures. The potential of the second set is calculated conventionally, that is, using atom pairs whose interactions were determined by their separation distances. The scoring potentials were tested against two different docking decoy sets and their performances were compared. The results show that, if properly optimized, the Delaunay-based scoring potentials can achieve higher success rate than the usual scoring potentials. These results and the results of a previous study on the use of Delaunay-based potentials in protein fold recognition, all point to the fact that Delaunay tessellation of protein structure can provide a more realistic definition of atomic interaction, and therefore, if appropriately utilized, may be able to improve the accuracy of pair potentials. PMID:27060891

  5. Modeling the Effect of Replacing Sugar-Sweetened Beverage Consumption with Water on Energy Intake, HBI Score, and Obesity Prevalence

    Directory of Open Access Journals (Sweden)

    Kiyah J. Duffey

    2016-06-01

    Full Text Available Sugar-sweetened beverages (SSB contribute to excessive weight gain through added energy intake. Replacing SSB with water is one strategy that has shown promise in helping lower excessive energy intake. Using nationally representative data from US adults (n = 19,718 from NHANES 2007–2012 we examine the impact of replacing SSB with water on Healthy Beverage Index (HBI scores and obesity prevalence. Replacing an 8-ounce serving of SSB with water lowered the percent of energy from beverages from 17% to 11% (among those consuming 1 serving SSB/day. Reductions in the percent energy from beverages were observed across all SSB consumption groups (1–2 servings/day and >2 servings/day. Among adults there was a 9% to 21% improvement in HBI score when one serving of water replaced one serving of SSB. Using previously published randomized controlled trials (RCT and meta-analyses of measured weight loss we also predicted a reduction in the prevalence of obesity (observed: 35.2%; predicted 33.5%–34.9%, p < 0.05 and increase in the prevalence of normal weight (observed: 29.7%; high weight loss: 31.3%, p < 0.05. Our findings provide further epidemiologic evidence that water in the place of SSB can be used as a strategy to limit energy intake and help individuals meet beverage intake recommendations.

  6. Modeling the Effect of Replacing Sugar-Sweetened Beverage Consumption with Water on Energy Intake, HBI Score, and Obesity Prevalence

    Science.gov (United States)

    Duffey, Kiyah J.; Poti, Jennifer

    2016-01-01

    Sugar-sweetened beverages (SSB) contribute to excessive weight gain through added energy intake. Replacing SSB with water is one strategy that has shown promise in helping lower excessive energy intake. Using nationally representative data from US adults (n = 19,718) from NHANES 2007–2012 we examine the impact of replacing SSB with water on Healthy Beverage Index (HBI) scores and obesity prevalence. Replacing an 8-ounce serving of SSB with water lowered the percent of energy from beverages from 17% to 11% (among those consuming 1 serving SSB/day). Reductions in the percent energy from beverages were observed across all SSB consumption groups (1–2 servings/day and >2 servings/day). Among adults there was a 9% to 21% improvement in HBI score when one serving of water replaced one serving of SSB. Using previously published randomized controlled trials (RCT) and meta-analyses of measured weight loss we also predicted a reduction in the prevalence of obesity (observed: 35.2%; predicted 33.5%–34.9%, p < 0.05) and increase in the prevalence of normal weight (observed: 29.7%; high weight loss: 31.3%, p < 0.05). Our findings provide further epidemiologic evidence that water in the place of SSB can be used as a strategy to limit energy intake and help individuals meet beverage intake recommendations. PMID:27367719

  7. Modeling the Effect of Replacing Sugar-Sweetened Beverage Consumption with Water on Energy Intake, HBI Score, and Obesity Prevalence.

    Science.gov (United States)

    Duffey, Kiyah J; Poti, Jennifer

    2016-01-01

    Sugar-sweetened beverages (SSB) contribute to excessive weight gain through added energy intake. Replacing SSB with water is one strategy that has shown promise in helping lower excessive energy intake. Using nationally representative data from US adults (n = 19,718) from NHANES 2007-2012 we examine the impact of replacing SSB with water on Healthy Beverage Index (HBI) scores and obesity prevalence. Replacing an 8-ounce serving of SSB with water lowered the percent of energy from beverages from 17% to 11% (among those consuming 1 serving SSB/day). Reductions in the percent energy from beverages were observed across all SSB consumption groups (1-2 servings/day and >2 servings/day). Among adults there was a 9% to 21% improvement in HBI score when one serving of water replaced one serving of SSB. Using previously published randomized controlled trials (RCT) and meta-analyses of measured weight loss we also predicted a reduction in the prevalence of obesity (observed: 35.2%; predicted 33.5%-34.9%, p < 0.05) and increase in the prevalence of normal weight (observed: 29.7%; high weight loss: 31.3%, p < 0.05). Our findings provide further epidemiologic evidence that water in the place of SSB can be used as a strategy to limit energy intake and help individuals meet beverage intake recommendations. PMID:27367719

  8. Development and validation of a visual body condition scoring system for dairy goats with picture-based training.

    Science.gov (United States)

    Vieira, A; Brandão, S; Monteiro, A; Ajuda, I; Stilwell, G

    2015-09-01

    Body condition scoring (BCS) is the most widely used method to assess changes in body fat reserves, which reflects its high potential to be included in on-farm welfare assessment protocols. Currently used scoring systems in dairy goats require animal restraint for body palpation. In this study, the Animal Welfare Indicators project (AWIN) proposes to overcome this constraint by developing a scoring system based only on visual assessment. The AWIN visual body condition scoring system highlights representative animals from 3 categories: very thin, normal, and very fat, and was built from data sets with photographs of animals scored by a commonly used 6-point scoring system that requires palpation in 2 anatomical regions. Development of the AWIN scoring system required 3 steps: (1) identification and validation of a body region of interest; (2) sketching the region from photographs; and (3) creation of training material. The scoring system's reliability was statistically confirmed. An initial study identified features in the rump region from which we could compute a set of body measurements (i.e., measures based on anatomical references of the rump region) that showed a strong correlation with the assigned BCS. To validate the result, we collected a final data set from 171 goats. To account for variability in animal size and camera position, we mapped a subset of features to a standard template and aligned all the rump images before computing the body measurements. Scientific illustrations were created from the aligned images of animals identified as representative of each category to increase clarity and reproducibility. For training material, we created sketches representing the threshold between consecutive categories. Finally, we conducted 2 field reliability studies. In the first test, no training was given to 4 observers, whereas in the second, training using the threshold images was delivered to the same observers. In the first experiment, interobserver results

  9. Serious acute pyelonephritis: a predictive score for evaluation of deterioration of treatment based on clinical and radiologic findings using CT

    Energy Technology Data Exchange (ETDEWEB)

    Kim, See Hyung; Kim, Young Whan; Lee, Hee Jung (Department of Radiology, Keimyung University, Dongsan Hospital, Daegu (Korea, Republic of)), Email: kseehdr@dsmc.or.kr

    2012-03-15

    Background. Acute pyelonephritis (APN) requires prompt diagnosis and immediate treatment. Purpose To develop a simple score to assist in diagnosing treatment deterioration in patients with serious APN. Material and Methods. Using data from a retrospective cohort of 193 patients with APN, we developed scores based on multivariate logistic regression after the jackknife procedure. We validated the scores in a prospective cohort of 40 patients. Results. Nine criteria were independently associated with our investigation: Abscess (adjusted odds ratio [OR], 19.8; 95% confidence interval [95% CI] 4.5-72.1), pyonephrosis with or without stone (18.3; 4.8-70.9), pelvicalyceal air (15.5; 3.2-26.9), poor global excretion of contrast (12.3; 2.9-68.5), tachycardia or hypotension (10.1; 2.5-28.0), obliteration of the renal sinus (9.6; 2.5-45.2), persistent fever or pyuria (9.8; 1.9-25.8), diabetes (9.4; 2.0-31.8), and global renal enlargement (7.5; 2.1-35.8). The APN score was based on these nine criteria. Low-risk and high-risk groups were derived from the score (probability, 3.5% [95% CI 0-7.5] and 67% [51-83]). Application of these criteria to the prospective cohort confirmed the diagnostic accuracy of the score (probability 0% [0-15] and 71% [25-100] in the low-risk and high-risk groups, respectively). Conclusion. This easy-to-calculate score may prove useful for diagnosing patients with serious APN who deteriorate with treatment

  10. A scoring model based on neutrophil to lymphocyte ratio predicts recurrence of HBV-associated hepatocellular carcinoma after liver transplantation.

    Directory of Open Access Journals (Sweden)

    Guo-Ying Wang

    Full Text Available BACKGROUND: Neutrophil to lymphocyte ratio (NLR has been proposed to predict prognosis of hepatocellular carcinoma (HCC. However, the cut-off values are empirical. We determined the optimal cut-off value to predict HCC recurrence after liver transplantation (LT and further established a scoring model based on NLR. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed the outcome of 101 HBV-associated HCC patients undergoing LT. Preoperative risk factors for tumor recurrence were evaluated by univariate analysis. By using ROC analysis, NLR≥3 was considered elevated. The disease-free survival (DFS and overall survival (OS for patients with high NLR was significantly worse than that for patients with normal NLR (the 5-year DFS and OS of 28.5% and 19.5% vs. 64.9% and 61.8%, respectively; P5 cm, tumor number >3, macrovascular invasion, AFP≥400 µg/L, NLR≥3, and HBV-DNA level >5 log10 copies/mL were preoperative predictors of DFS. Cox regression analysis showed macrovascular invasion, tumor number, and high NLR were independent prognostic factors. We then established a preoperative prognostic score based on multivariate analysis. Each factor was given a score of 1. Area under the ROC curve of the score was 0.781. All nine patients with score 3 developed recurrence within 6 months after LT. Of 71 patients without vascular invasion, three patients with both tumor number >3 and NLR≥3 developed recurrence within 14 months after LT while the 5-year DFS and OS for patients with a score of 0 or 1 were 68.1% and 62.8%, respectively. CONCLUSIONS/SIGNIFICANCE: Preoperative elevated NLR significantly increases the risk of recurrence in patients underwent LT for HCC. Patients with both NLR≥3 and tumor number >3 are not a good indication for LT. Our score model may aid in the selection of patients that would most benefit from transplantation for HCC.

  11. Numeric score-based conditional and overall change-in-status indices for ordered categorical data.

    Science.gov (United States)

    Lyles, Robert H; Kupper, Lawrence L; Barnhart, Huiman X; Martin, Sandra L

    2015-11-30

    Planned interventions and/or natural conditions often effect change on an ordinal categorical outcome (e.g., symptom severity). In such scenarios, it is sometimes desirable to assign a priori scores to observed changes in status, typically giving higher weight to changes of greater magnitude. We define change indices for such data based upon a multinomial model for each row of a c × c table, where the rows represent the baseline status categories. We distinguish an index designed to assess conditional changes within each baseline category from two others designed to capture overall change. One of these overall indices measures expected change across a target population. The other is scaled to capture the proportion of total possible change in the direction indicated by the data, so that it ranges from -1 (when all subjects finish in the least favorable category) to +1 (when all finish in the most favorable category). The conditional assessment of change can be informative regardless of how subjects are sampled into the baseline categories. In contrast, the overall indices become relevant when subjects are randomly sampled at baseline from the target population of interest, or when the investigator is able to make certain assumptions about the baseline status distribution in that population. We use a Dirichlet-multinomial model to obtain Bayesian credible intervals for the conditional change index that exhibit favorable small-sample frequentist properties. Simulation studies illustrate the methods, and we apply them to examples involving changes in ordinal responses for studies of sleep deprivation and activities of daily living. PMID:26137898

  12. Nonlinear scoring functions for similarity-based ligand docking and binding affinity prediction.

    Science.gov (United States)

    Brylinski, Michal

    2013-11-25

    A common strategy for virtual screening considers a systematic docking of a large library of organic compounds into the target sites in protein receptors with promising leads selected based on favorable intermolecular interactions. Despite a continuous progress in the modeling of protein-ligand interactions for pharmaceutical design, important challenges still remain, thus the development of novel techniques is required. In this communication, we describe eSimDock, a new approach to ligand docking and binding affinity prediction. eSimDock employs nonlinear machine learning-based scoring functions to improve the accuracy of ligand ranking and similarity-based binding pose prediction, and to increase the tolerance to structural imperfections in the target structures. In large-scale benchmarking using the Astex/CCDC data set, we show that 53.9% (67.9%) of the predicted ligand poses have RMSD of <2 Å (<3 Å). Moreover, using binding sites predicted by recently developed eFindSite, eSimDock models ligand binding poses with an RMSD of 4 Å for 50.0-39.7% of the complexes at the protein homology level limited to 80-40%. Simulations against non-native receptor structures, whose mean backbone rearrangements vary from 0.5 to 5.0 Å Cα-RMSD, show that the ratio of docking accuracy and the estimated upper bound is at a constant level of ∼0.65. Pearson correlation coefficient between experimental and predicted by eSimDock Ki values for a large data set of the crystal structures of protein-ligand complexes from BindingDB is 0.58, which decreases only to 0.46 when target structures distorted to 3.0 Å Cα-RMSD are used. Finally, two case studies demonstrate that eSimDock can be customized to specific applications as well. These encouraging results show that the performance of eSimDock is largely unaffected by the deformations of ligand binding regions, thus it represents a practical strategy for across-proteome virtual screening using protein models. eSimDock is freely

  13. Fast index based algorithms and software for matching position specific scoring matrices

    Directory of Open Access Journals (Sweden)

    Homann Robert

    2006-08-01

    Full Text Available Abstract Background In biological sequence analysis, position specific scoring matrices (PSSMs are widely used to represent sequence motifs in nucleotide as well as amino acid sequences. Searching with PSSMs in complete genomes or large sequence databases is a common, but computationally expensive task. Results We present a new non-heuristic algorithm, called ESAsearch, to efficiently find matches of PSSMs in large databases. Our approach preprocesses the search space, e.g., a complete genome or a set of protein sequences, and builds an enhanced suffix array that is stored on file. This allows the searching of a database with a PSSM in sublinear expected time. Since ESAsearch benefits from small alphabets, we present a variant operating on sequences recoded according to a reduced alphabet. We also address the problem of non-comparable PSSM-scores by developing a method which allows the efficient computation of a matrix similarity threshold for a PSSM, given an E-value or a p-value. Our method is based on dynamic programming and, in contrast to other methods, it employs lazy evaluation of the dynamic programming matrix. We evaluated algorithm ESAsearch with nucleotide PSSMs and with amino acid PSSMs. Compared to the best previous methods, ESAsearch shows speedups of a factor between 17 and 275 for nucleotide PSSMs, and speedups up to factor 1.8 for amino acid PSSMs. Comparisons with the most widely used programs even show speedups by a factor of at least 3.8. Alphabet reduction yields an additional speedup factor of 2 on amino acid sequences compared to results achieved with the 20 symbol standard alphabet. The lazy evaluation method is also much faster than previous methods, with speedups of a factor between 3 and 330. Conclusion Our analysis of ESAsearch reveals sublinear runtime in the expected case, and linear runtime in the worst case for sequences not shorter than |A MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92Aae

  14. Turning Music Catalogues into Archives of Musical Scores – or Vice Versa: Music Archives and Catalogues Based on MEI XML

    DEFF Research Database (Denmark)

    Geertinger, Axel Teich

    2014-01-01

    Traditionally, digital collections of musical metadata, i.e., information about musical works – such as library catalogues or thematic catalogues are based on relational databases. Digital archives of musical scores, on the other hand, usually consist of collections of files, each containing one ...

  15. Target Practice: Reader Response Theory and Teachers' Interpretations of Students' SAT 10 Scores in Data-Based Professional Development

    Science.gov (United States)

    Atkinson, Becky M.

    2012-01-01

    The study reported in this article examines how teachers read and respond to their students' Stanford Achievement Test 10 (SAT 10) scores with the goal of investigating the assumption that data-based teaching practice is more "objective" and less susceptible to divergent teacher interpretation. The study uses reader response theory to frame…

  16. Effect of Clinically Discriminating, Evidence-Based Checklist Items on the Reliability of Scores from an Internal Medicine Residency OSCE

    Science.gov (United States)

    Daniels, Vijay J.; Bordage, Georges; Gierl, Mark J.; Yudkowsky, Rachel

    2014-01-01

    Objective structured clinical examinations (OSCEs) are used worldwide for summative examinations but often lack acceptable reliability. Research has shown that reliability of scores increases if OSCE checklists for medical students include only clinically relevant items. Also, checklists are often missing evidence-based items that high-achieving…

  17. An image based system to automatically and objectivelly score the degreeof redness and scaling in psoriasi lesions

    DEFF Research Database (Denmark)

    Gomez, David Delgado; Ersbøll, Bjarne Kjær; Carstensen, Jens Michael

    2004-01-01

    In this work, a combined statistical and image analysis method to automatically evaluate the severity of scaling in psoriasis lesions is proposed. The method separates the different regions of the disease in the image and scores the degree of scaling based on the properties of these areas. The pr...

  18. The impact of a revised EQ-5D population scoring on preference-based utility scores in an inflammatory arthritis cohort.

    LENUS (Irish Health Repository)

    Adams, Roisin

    2012-02-01

    BACKGROUND AND OBJECTIVE: It is well established that there are problems with the EQ-5D. This is due to the original scoring methods used and how negative time trade-off (TTO) values were treated. A revised scoring method has been published. This article applies this to an inflammatory arthritis cohort. The objective is to examine the impact of a revised scoring system for the EQ-5D (UK) TTO on the utility estimates and in the case of rheumatoid arthritis, to explore the impact of using different utility metrics on the incremental cost-effectiveness ratio (ICER) results of an economic model. METHODS: A total of 504 patients with inflammatory arthritis were rescored using revised EQ-5D scoring, which uses an episodic random utility model to deal with negative TTO values. Differences in utility scores were compared and the new mapping coefficients were obtained. These were then used in an economic model to examine the impact on the ICER. RESULTS: In rheumatoid arthritis, the overall change is less for the revised EQ-5D scoring than with the original EQ-5D (TTO) but greater than the SF-6D: EQ-5D UK -0.22 (95% confidence interval [CI] -0.30 to -0.15), revised EQ-5D UK -0.16 (95% CI -0.21 to -0.10) and SF-6D -0.08 (95% CI -0.11 to -0.05). A similar trend is seen in the psoriatic arthritis group. The economic model produced different ICERs, when different utility measures were used; EQ-5D (TTO) euro42,402, SF-6D euro111,788, and revised EQ-5D (TTO) euro57,747. CONCLUSION: In the context of inflammatory arthritis, this article demonstrates that a revised scoring for EQ-5D may have a significant impact on utility estimates and on the output of the economic model.

  19. An Assessment of Statistical Process Control-Based Approaches for Charting Student Evaluation Scores

    Science.gov (United States)

    Ding, Xin; Wardell, Don; Verma, Rohit

    2006-01-01

    We compare three control charts for monitoring data from student evaluations of teaching (SET) with the goal of improving student satisfaction with teaching performance. The two charts that we propose are a modified "p" chart and a z-score chart. We show that these charts overcome some of the shortcomings of the more traditional charts…

  20. An Inmate Classification System Based on PCL: SV Factor Scores in a Sample of Prison Inmates

    Science.gov (United States)

    Wogan, Michael; Mackenzie, Marci

    2007-01-01

    Psychopaths represent a significant management challenge in a prison population. A sample of ninety-five male inmates from three medium security prisons was tested using the Hare Psychopathy Checklist: Screening Version (PCL:SV). Using traditional criteria, 22% of the inmates were classified as psychopaths. Scores on the two factor dimensions of…

  1. Meditation Breath Attention Scores (MBAS): Development and investigation of an internet-based assessment of focused attention during meditation practice.

    Science.gov (United States)

    Frewen, Paul; Hargraves, Heather; DePierro, Jonathan; D'Andrea, Wendy; Flodrowski, Les

    2016-07-01

    Meditation Breath Attention Scores (MBAS) represent a self-report, state measure of focused attention (FA) during the practice of meditation. The MBAS assessment procedure involves sounding a bell at periodic intervals during meditation practice, at which times participants indicate if they were attending toward breathing (scored 1) or if instead they had become distracted (e.g., by mind wandering; scored 0); scores are then tallied to yield participants' MBAS for that meditation. The current study developed and evaluated a fully automated and Internet-based version of MBAS in 1,101 volunteers. Results suggested that: (a) MBAS are internally consistent across bell rings; (b) MBAS total scores exhibit a non-normal distribution identifying subgroups of participants with particularly poor or robust FA during meditation; (c) MBAS decrease linearly with the duration of meditation practices, indicating that participants tend to experience less FA later as opposed to earlier in the meditation; (d) in the case of eyes-open meditation, MBAS are higher when the amount of time between bells is shorter; (e) MBAS correlate with various self-reported subjective experiences occurring during meditation; and (f) MBAS are weakly associated with higher trait mindful "acting with awareness," lesser ADHD-related symptoms of inattentiveness, and estimated minutes of meditation practiced in the past month. In sum, results provide further support for the construct validity of MBAS and serve to further characterize the dynamics of individual differences in FA during meditation. (PsycINFO Database Record PMID:27078182

  2. AP Potential™ Expectancy Tables Based on PSAT/NMSQT® and SAT® Scores on the 2015-16 Redesigned Scales. Statistical Report 2016-2

    Science.gov (United States)

    Ewing, Maureen; Wyatt, Jeffrey N.; Smith, Kara

    2016-01-01

    Historically, AP Potential™ has used PSAT/NMSQT® scores to identify students who are likely to earn a 3 or higher on a specific AP® Exam--based on research showing moderate to strong relationships between PSAT/NMSQT scores and AP Exam scores (Camara & Millsap, 1998; Ewing, Camara & Millsap, 2006; Zhang, Patel & Ewing, 2014a). For most…

  3. Optimization of MRI-based scoring scales of brain injury severity in children with unilateral cerebral palsy

    Energy Technology Data Exchange (ETDEWEB)

    Pagnozzi, Alex M. [Royal Brisbane and Women' s Hospital, CSIRO Digital Productivity and Services Flagship, The Australian e-Health Research Centre, Herston, QLD (Australia); The University of Queensland, School of Medicine, Brisbane (Australia); Fiori, Simona [Stella Maris Scientific Institute, Pisa (Italy); Boyd, Roslyn N. [The University of Queensland, Queensland Cerebral Palsy and Rehabilitation Research Centre, School of Medicine, Brisbane (Australia); Guzzetta, Andrea [Stella Maris Scientific Institute, Pisa (Italy); University of Pisa, Department of Clinical and Experimental Medicine, Pisa (Italy); Doecke, James; Rose, Stephen; Dowson, Nicholas [Royal Brisbane and Women' s Hospital, CSIRO Digital Productivity and Services Flagship, The Australian e-Health Research Centre, Herston, QLD (Australia); Gal, Yaniv [The University of Queensland, Centre for Medical Diagnostic Technologies in Queensland, Brisbane (Australia)

    2016-02-15

    Several scoring systems for measuring brain injury severity have been developed to standardize the classification of MRI results, which allows for the prediction of functional outcomes to help plan effective interventions for children with cerebral palsy. The aim of this study is to use statistical techniques to optimize the clinical utility of a recently proposed template-based scoring method by weighting individual anatomical scores of injury, while maintaining its simplicity by retaining only a subset of scored anatomical regions. Seventy-six children with unilateral cerebral palsy were evaluated in terms of upper limb motor function using the Assisting Hand Assessment measure and injuries visible on MRI using a semiquantitative approach. This cohort included 52 children with periventricular white matter injury and 24 with cortical and deep gray matter injuries. A subset of the template-derived cerebral regions was selected using a data-driven region selection algorithm. Linear regression was performed using this subset, with interaction effects excluded. Linear regression improved multiple correlations between MRI-based and Assisting Hand Assessment scores for both periventricular white matter (R squared increased to 0.45 from 0, P < 0.0001) and cortical and deep gray matter (0.84 from 0.44, P < 0.0001) cohorts. In both cohorts, the data-driven approach retained fewer than 8 of the 40 template-derived anatomical regions. The equal or better prediction of the clinically meaningful Assisting Hand Assessment measure using fewer anatomical regions highlights the potential of these developments to enable enhanced quantification of injury and prediction of patient motor outcome, while maintaining the clinical expediency of the scoring approach. (orig.)

  4. Optimization of MRI-based scoring scales of brain injury severity in children with unilateral cerebral palsy

    International Nuclear Information System (INIS)

    Several scoring systems for measuring brain injury severity have been developed to standardize the classification of MRI results, which allows for the prediction of functional outcomes to help plan effective interventions for children with cerebral palsy. The aim of this study is to use statistical techniques to optimize the clinical utility of a recently proposed template-based scoring method by weighting individual anatomical scores of injury, while maintaining its simplicity by retaining only a subset of scored anatomical regions. Seventy-six children with unilateral cerebral palsy were evaluated in terms of upper limb motor function using the Assisting Hand Assessment measure and injuries visible on MRI using a semiquantitative approach. This cohort included 52 children with periventricular white matter injury and 24 with cortical and deep gray matter injuries. A subset of the template-derived cerebral regions was selected using a data-driven region selection algorithm. Linear regression was performed using this subset, with interaction effects excluded. Linear regression improved multiple correlations between MRI-based and Assisting Hand Assessment scores for both periventricular white matter (R squared increased to 0.45 from 0, P < 0.0001) and cortical and deep gray matter (0.84 from 0.44, P < 0.0001) cohorts. In both cohorts, the data-driven approach retained fewer than 8 of the 40 template-derived anatomical regions. The equal or better prediction of the clinically meaningful Assisting Hand Assessment measure using fewer anatomical regions highlights the potential of these developments to enable enhanced quantification of injury and prediction of patient motor outcome, while maintaining the clinical expediency of the scoring approach. (orig.)

  5. LoCo: a novel main chain scoring function for protein structure prediction based on local coordinates

    Directory of Open Access Journals (Sweden)

    Samudrala Ram

    2011-09-01

    Full Text Available Abstract Background Successful protein structure prediction requires accurate low-resolution scoring functions so that protein main chain conformations that are close to the native can be identified. Once that is accomplished, a more detailed and time-consuming treatment to produce all-atom models can be undertaken. The earliest low-resolution scoring used simple distance-based "contact potentials," but more recently, the relative orientations of interacting amino acids have been taken into account to improve performance. Results We developed a new knowledge-based scoring function, LoCo, that locates the interaction partners of each individual residue within a local coordinate system based only on the position of its main chain N, Cα and C atoms. LoCo was trained on a large set of experimentally determined structures and optimized using standard sets of modeled structures, or "decoys." No structure used to train or optimize the function was included among those used to test it. When tested against 29 other published main chain functions on a group of 77 commonly used decoy sets, our function outperformed all others in Cα RMSD rank of the best-scoring decoy, with statistically significant p-values Conclusions Our function demonstrates an unmatched combination of accuracy, speed, and simplicity and shows excellent promise for protein structure prediction. Broader applications may include protein-protein interactions and protein design.

  6. A Prognostic Model Using Inflammation- and Nutrition-Based Scores in Patients With Metastatic Gastric Adenocarcinoma Treated With Chemotherapy

    Science.gov (United States)

    Hsieh, Meng-Che; Wang, Shih-Hor; Chuah, Seng-Kee; Lin, Yu-Hung; Lan, Jui; Rau, Kun-Ming

    2016-01-01

    Abstract The outcomes of patients with metastatic gastric cancer (mGC) are poor. Recent studies have identified the prognostic impact of inflammatory response and nutritional status on survival for patients with gastric cancer. This study aims to create a prognostic model using inflammatory- and nutrition-based scores to predict survival in patients with mGC treated with chemotherapy. After institutional review board approval, patients who had mGC and were treated with chemotherapy from 2007 to 2012 at Kaohsiung Chang Gung Memorial Hospital were retrospectively reviewed. Significantly predictive factors were identified by multivariate Cox regression analyses. Based on these variables, a prognostic model using inflammatory- and nutrition-based scores was constructed to predict survival. Kaplan-Meier curves were plotted to estimate overall survival. The c-statistic values with 95% confidence interval (CI) were also calculated to access their predicting performances. Our study consisted of 256 patients with a median age of 60 years and a median follow-up visit of 18.5 months. Multivariate analyses showed that neutrophil to lymphocyte ratio (NLR), modified Glasgow prognostic score (mGPS), and Patient-Generated Subjective Global Assessment (PG-SGA) were independently related to survival. After computing these scores, patients were classified into favorable-, intermediate-, and poor-risk groups. The median overall survival were 27.6 versus 13.2 versus 8.2 months in favorable, intermediate, and poor-risk groups, respectively. The 2-year survival rate was 52% versus 16% versus 3% in favorable-, intermediate-, and poor-risk groups, respectively. (P < 0.001). The c-statistic value of our model at 2 years is 0.8 (95% CI, 0.75–0.86). NLR, mGPS, and PG-SGA were independently related to survival. Our prognostic model using inflammatory- and nutrition-based scores could provide prognostic information to patients and physicians. PMID:27124056

  7. A Prognostic Model Using Inflammation- and Nutrition-Based Scores in Patients With Metastatic Gastric Adenocarcinoma Treated With Chemotherapy.

    Science.gov (United States)

    Hsieh, Meng-Che; Wang, Shih-Hor; Chuah, Seng-Kee; Lin, Yu-Hung; Lan, Jui; Rau, Kun-Ming

    2016-04-01

    The outcomes of patients with metastatic gastric cancer (mGC) are poor. Recent studies have identified the prognostic impact of inflammatory response and nutritional status on survival for patients with gastric cancer. This study aims to create a prognostic model using inflammatory- and nutrition-based scores to predict survival in patients with mGC treated with chemotherapy.After institutional review board approval, patients who had mGC and were treated with chemotherapy from 2007 to 2012 at Kaohsiung Chang Gung Memorial Hospital were retrospectively reviewed. Significantly predictive factors were identified by multivariate Cox regression analyses. Based on these variables, a prognostic model using inflammatory- and nutrition-based scores was constructed to predict survival. Kaplan-Meier curves were plotted to estimate overall survival. The c-statistic values with 95% confidence interval (CI) were also calculated to access their predicting performances.Our study consisted of 256 patients with a median age of 60 years and a median follow-up visit of 18.5 months. Multivariate analyses showed that neutrophil to lymphocyte ratio (NLR), modified Glasgow prognostic score (mGPS), and Patient-Generated Subjective Global Assessment (PG-SGA) were independently related to survival. After computing these scores, patients were classified into favorable-, intermediate-, and poor-risk groups. The median overall survival were 27.6 versus 13.2 versus 8.2 months in favorable, intermediate, and poor-risk groups, respectively. The 2-year survival rate was 52% versus 16% versus 3% in favorable-, intermediate-, and poor-risk groups, respectively. (P < 0.001). The c-statistic value of our model at 2 years is 0.8 (95% CI, 0.75-0.86).NLR, mGPS, and PG-SGA were independently related to survival. Our prognostic model using inflammatory- and nutrition-based scores could provide prognostic information to patients and physicians. PMID:27124056

  8. The effect of radar-based QPE on the Fractions Skill Score used at the QPF verification

    OpenAIRE

    P. Zacharov; D. Rezacova

    2010-01-01

    In this paper we show the influence of gauge adjustment technique, applied to radar-based rainfalls, on the results of QPF verification. The results were obtained for four convective events which produced heavy local rainfalls and caused local flash floods at the Czech territory. Numerical weather prediction model COSMO was run to obtain rainfall forecast and Fractions Skill Score was employed in the QPF verification. Three different radar-based quantitative precipitation ...

  9. Reproducibility of the NEPTUNE descriptor-based scoring system on whole-slide images and histologic and ultrastructural digital images.

    Science.gov (United States)

    Barisoni, Laura; Troost, Jonathan P; Nast, Cynthia; Bagnasco, Serena; Avila-Casado, Carmen; Hodgin, Jeffrey; Palmer, Matthew; Rosenberg, Avi; Gasim, Adil; Liensziewski, Chrysta; Merlino, Lino; Chien, Hui-Ping; Chang, Anthony; Meehan, Shane M; Gaut, Joseph; Song, Peter; Holzman, Lawrence; Gibson, Debbie; Kretzler, Matthias; Gillespie, Brenda W; Hewitt, Stephen M

    2016-07-01

    The multicenter Nephrotic Syndrome Study Network (NEPTUNE) digital pathology scoring system employs a novel and comprehensive methodology to document pathologic features from whole-slide images, immunofluorescence and ultrastructural digital images. To estimate inter- and intra-reader concordance of this descriptor-based approach, data from 12 pathologists (eight NEPTUNE and four non-NEPTUNE) with experience from training to 30 years were collected. A descriptor reference manual was generated and a webinar-based protocol for consensus/cross-training implemented. Intra-reader concordance for 51 glomerular descriptors was evaluated on jpeg images by seven NEPTUNE pathologists scoring 131 glomeruli three times (Tests I, II, and III), each test following a consensus webinar review. Inter-reader concordance of glomerular descriptors was evaluated in 315 glomeruli by all pathologists; interstitial fibrosis and tubular atrophy (244 cases, whole-slide images) and four ultrastructural podocyte descriptors (178 cases, jpeg images) were evaluated once by six and five pathologists, respectively. Cohen's kappa for inter-reader concordance for 48/51 glomerular descriptors with sufficient observations was moderate (0.40transformation. NEPTUNE digital pathology scoring system enables novel morphologic profiling of renal structures. For all histologic and ultrastructural descriptors tested with sufficient observations, moderate-to-excellent concordance was seen for 31/54 (57%). Descriptors not sufficiently represented will require further testing. This study proffers the NEPTUNE digital pathology scoring system as a model for standardization of renal biopsy interpretation extendable outside the NEPTUNE consortium, enabling international collaborations. PMID:27102348

  10. AN EXCEL-BASED DECISION SUPPORT SYSTEM FOR SCORING AND RANKING PROPOSED R&D PROJECTS

    OpenAIRE

    ANNE DE PIANTE HENRIKSEN; SUSAN W. PALOCSAY

    2008-01-01

    One of the most challenging aspects of technology management is the selection of research and development (R&D) projects from among a group of proposals. This paper introduces an interactive, user-friendly decision support system for evaluating and ranking R&D projects and demonstrates its application on an example R&D program. It employs the scoring methodology developed by Henriksen and Traynor to provide a practical technique that considers both project merit and project cost in the evalua...

  11. AN INTEGRATED GENETIC-BASED MODEL OF NAIVE BAYES NETWORKS FOR CREDIT SCORING

    OpenAIRE

    Ali Zeinal Hamadani; Ali shalbafzadeh; Taghi Rezvan; AfshinShahlayi Moghadam

    2013-01-01

    Inappropriate management in some fields such as credit allocation has imposed too many losses to financial institutions and even has forced some of them to go bankrupt. Moreover, large volume data sets collected by credit departments has necessitated utilizing highly accurate models with less complexities. Credit scoring models with classification and forecasting customers into two groups good and bad can dramatically reduce risks of granting credits to customers. In this paper...

  12. AN INTEGRATED GENETIC-BASED MODEL OF NAIVE BAYES NETWORKS FOR CREDIT SCORING

    Directory of Open Access Journals (Sweden)

    Ali Zeinal Hamadani1

    2013-01-01

    Full Text Available Inappropriate management in some fields such as credit allocation has imposed too many losses to financial institutions and even has forced some of them to go bankrupt. Moreover, large volume data sets collected by credit departments has necessitated utilizing highly accurate models with less complexities. Credit scoring models with classification and forecasting customers into two groups good and bad can dramatically reduce risks of granting credits to customers. In this paper, a novel integrated approach for credit scoring problem is presented. This approach utilizes rough sets for feature selection during the data pre-processing phase and also adopts two hybrid sequences, Naïve Bayes networks and genetic algorithm, to classify customers. In order to assess the competitive performance of the proposed approach, it has been executed on three credit scoring datasets from the University of California Irvine Machine Learning Repository. Computational results demonstrate that our approach has superior performance in terms of classification accuracy and achieves higher overall classification rate as compared to several other previous studies.

  13. A novel approach for lie detection based on F-score and extreme learning machine.

    Directory of Open Access Journals (Sweden)

    Junfeng Gao

    Full Text Available A new machine learning method referred to as F-score_ELM was proposed to classify the lying and truth-telling using the electroencephalogram (EEG signals from 28 guilty and innocent subjects. Thirty-one features were extracted from the probe responses from these subjects. Then, a recently-developed classifier called extreme learning machine (ELM was combined with F-score, a simple but effective feature selection method, to jointly optimize the number of the hidden nodes of ELM and the feature subset by a grid-searching training procedure. The method was compared to two classification models combining principal component analysis with back-propagation network and support vector machine classifiers. We thoroughly assessed the performance of these classification models including the training and testing time, sensitivity and specificity from the training and testing sets, as well as network size. The experimental results showed that the number of the hidden nodes can be effectively optimized by the proposed method. Also, F-score_ELM obtained the best classification accuracy and required the shortest training and testing time.

  14. An Integrated Genetic-Based Model of Naive Bayes Networks for Credit Scoring

    Directory of Open Access Journals (Sweden)

    Ali Zeinal Hamadani

    2013-02-01

    Full Text Available Inappropriate management in some fields such as credit allocation has imposed too many losses tofinancial institutions and even has forced some of them to go bankrupt. Moreover, large volume data setscollected by credit departments has necessitated utilizing highly accurate models with less complexities.Credit scoring models with classification and forecasting customers into two groups good and bad candramatically reduce risks of granting credits to customers.In this paper, a novel integrated approach for credit scoring problem is presented. This approach utilizesrough sets for feature selection during the data pre-processing phase and also adopts two hybridsequences, Naïve Bayes networks and genetic algorithm, to classify customers. In order to assess thecompetitive performance of the proposed approach, it has been executed on three credit scoring datasetsfrom the University of California Irvine Machine Learning Repository. Computational results demonstratethat our approach has superior performance in terms of classification accuracy and achieves higheroverall classification rate as compared to several other previous studies.

  15. Chest computed tomography-based scoring of thoracic sarcoidosis: Inter-rater reliability of CT abnormalities

    Energy Technology Data Exchange (ETDEWEB)

    Heuvel, D.A.V. den; Es, H.W. van; Heesewijk, J.P. van; Spee, M. [St. Antonius Hospital Nieuwegein, Department of Radiology, Nieuwegein (Netherlands); Jong, P.A. de [University Medical Center Utrecht, Department of Radiology, Utrecht (Netherlands); Zanen, P.; Grutters, J.C. [University Medical Center Utrecht, Division Heart and Lungs, Utrecht (Netherlands); St. Antonius Hospital Nieuwegein, Center of Interstitial Lung Diseases, Department of Pulmonology, Nieuwegein (Netherlands)

    2015-09-15

    To determine inter-rater reliability of sarcoidosis-related computed tomography (CT) findings that can be used for scoring of thoracic sarcoidosis. CT images of 51 patients with sarcoidosis were scored by five chest radiologists for various abnormal CT findings (22 in total) encountered in thoracic sarcoidosis. Using intra-class correlation coefficient (ICC) analysis, inter-rater reliability was analysed and reported according to the Guidelines for Reporting Reliability and Agreement Studies (GRRAS) criteria. A pre-specified sub-analysis was performed to investigate the effect of training. Scoring was trained in a distinct set of 15 scans in which all abnormal CT findings were represented. Median age of the 51 patients (36 men, 70 %) was 43 years (range 26 - 64 years). All radiographic stages were present in this group. ICC ranged from 0.91 for honeycombing to 0.11 for nodular margin (sharp versus ill-defined). The ICC was above 0.60 in 13 of the 22 abnormal findings. Sub-analysis for the best-trained observers demonstrated an ICC improvement for all abnormal findings and values above 0.60 for 16 of the 22 abnormalities. In our cohort, reliability between raters was acceptable for 16 thoracic sarcoidosis-related abnormal CT findings. (orig.)

  16. The Chemistry Scoring Index (CSI: A Hazard-Based Scoring and Ranking Tool for Chemicals and Products Used in the Oil and Gas Industry

    Directory of Open Access Journals (Sweden)

    Tim Verslycke

    2014-06-01

    Full Text Available A large portfolio of chemicals and products is needed to meet the wide range of performance requirements of the oil and gas industry. The oil and gas industry is under increased scrutiny from regulators, environmental groups, the public, and other stakeholders for use of their chemicals. In response, industry is increasingly incorporating “greener” products and practices but is struggling to define and quantify what exactly constitutes “green” in the absence of a universally accepted definition. We recently developed the Chemistry Scoring Index (CSI which is ultimately intended to be a globally implementable tool that comprehensively scores and ranks hazards to human health, safety, and the environment for products used in oil and gas operations. CSI scores are assigned to products designed for the same use (e.g., surfactants, catalysts on the basis of product composition as well as intrinsic hazard properties and data availability for each product component. As such, products with a lower CSI score within a product use group are considered to have a lower intrinsic hazard compared to other products within the same use group. The CSI provides a powerful tool to evaluate relative product hazards; to review and assess product portfolios; and to aid in the formulation of products.

  17. Risk of Pathologic Upgrading or Locally Advanced Disease in Early Prostate Cancer Patients Based on Biopsy Gleason Score and PSA: A Population-Based Study of Modern Patients

    Energy Technology Data Exchange (ETDEWEB)

    Caster, Joseph M.; Falchook, Aaron D. [Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Hendrix, Laura H. [Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Chen, Ronald C., E-mail: Ronald_chen@med.unc.edu [Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States)

    2015-06-01

    Purpose: Radiation oncologists rely on available clinical information (biopsy Gleason score and prostate-specific antigen [PSA]) to determine the optimal treatment regimen for each prostate cancer patient. Existing published nomograms correlating clinical to pathologic extent of disease were based on patients treated in the 1980s and 1990s at select academic institutions. We used the Surveillance, Epidemiology, and End Results (SEER) database to examine pathologic outcomes (Gleason score and cancer stage) in early prostate cancer patients based on biopsy Gleason score and PSA concentration. Methods and Materials: This analysis included 25,858 patients whose cancer was diagnosed between 2010 and 2011, with biopsy Gleason scores of 6 to 7 and clinical stage T1 to T2 disease, who underwent radical prostatectomy. In subgroups based on biopsy Gleason score and PSA level, we report the proportion of patients with pathologically advanced disease (positive surgical margin or pT3-T4 disease) or whose Gleason score was upgraded. Logistic regression was used to examine factors associated with pathologic outcomes. Results: For patients with biopsy Gleason score 6 cancers, 84% of those with PSA <10 ng/mL had surgical T2 disease with negative margins; this decreased to 61% in patients with PSA of 20 to 29.9 ng/mL. Gleason score upgrading was seen in 43% (PSA: <10 ng/mL) to 61% (PSA: 20-29.9 ng/mL) of biopsy Gleason 6 patients. Patients with biopsy Gleason 7 cancers had a one-third (Gleason 3 + 4; PSA: <10 ng/mL) to two-thirds (Gleason 4 + 3; PSA: 20-29.9 ng/mL) probability of having pathologically advanced disease. Gleason score upgrading was seen in 11% to 19% of patients with biopsy Gleason 4 + 3 cancers. Multivariable analysis showed that higher PSA and older age were associated with Gleason score upgrading and pathologically advanced disease. Conclusions: This is the first population-based study to examine pathologic extent of disease and pathologic Gleason score

  18. Risk of Pathologic Upgrading or Locally Advanced Disease in Early Prostate Cancer Patients Based on Biopsy Gleason Score and PSA: A Population-Based Study of Modern Patients

    International Nuclear Information System (INIS)

    Purpose: Radiation oncologists rely on available clinical information (biopsy Gleason score and prostate-specific antigen [PSA]) to determine the optimal treatment regimen for each prostate cancer patient. Existing published nomograms correlating clinical to pathologic extent of disease were based on patients treated in the 1980s and 1990s at select academic institutions. We used the Surveillance, Epidemiology, and End Results (SEER) database to examine pathologic outcomes (Gleason score and cancer stage) in early prostate cancer patients based on biopsy Gleason score and PSA concentration. Methods and Materials: This analysis included 25,858 patients whose cancer was diagnosed between 2010 and 2011, with biopsy Gleason scores of 6 to 7 and clinical stage T1 to T2 disease, who underwent radical prostatectomy. In subgroups based on biopsy Gleason score and PSA level, we report the proportion of patients with pathologically advanced disease (positive surgical margin or pT3-T4 disease) or whose Gleason score was upgraded. Logistic regression was used to examine factors associated with pathologic outcomes. Results: For patients with biopsy Gleason score 6 cancers, 84% of those with PSA <10 ng/mL had surgical T2 disease with negative margins; this decreased to 61% in patients with PSA of 20 to 29.9 ng/mL. Gleason score upgrading was seen in 43% (PSA: <10 ng/mL) to 61% (PSA: 20-29.9 ng/mL) of biopsy Gleason 6 patients. Patients with biopsy Gleason 7 cancers had a one-third (Gleason 3 + 4; PSA: <10 ng/mL) to two-thirds (Gleason 4 + 3; PSA: 20-29.9 ng/mL) probability of having pathologically advanced disease. Gleason score upgrading was seen in 11% to 19% of patients with biopsy Gleason 4 + 3 cancers. Multivariable analysis showed that higher PSA and older age were associated with Gleason score upgrading and pathologically advanced disease. Conclusions: This is the first population-based study to examine pathologic extent of disease and pathologic Gleason score

  19. The Effect of Forming a Score-Based Competitive System in a Cyber-Drilling Atmosphere for Learning and Motivation

    Directory of Open Access Journals (Sweden)

    Bekir ÇELEN

    2009-01-01

    Full Text Available This research focuses on to carry out a structure, in which the desire of having a high score and seeing the name in the top list is used in web-based drills and helps students to be more willing in test solving. The purpose of this study is to determine the effects of web-based drills on motivation and learning in a competitive atmosphere. Furthermore, the study also attempts to determine if the students’ levels and frequency of using a computer have an effect on the test scores in a web based system.Over a period of two week application students logged in the system using their own passwords and solve questions whenever they wanted. The names and photographs of the students who achieved the best scores were declared on the school’s website. In the study, an experimental design has been applied. The data were collected through the database in the web-based drill, pre and post survey to determine the level of and the reasons for students’ use of the website and history common exam results. According to the findings of the research, the website that has the competitive atmosphere has a positive effect on students’ achievement in their lessons. The application led to a change in students’ aim to visit the website and the frequency of their visits.

  20. Scoring predictive models using a reduced representation of proteins: model and energy definition

    OpenAIRE

    Corazza Alessandra; Giugliarelli Gilberto; Bortolussi Luca; Dovier Agostino; Pieri Lidia; Fogolari Federico; Esposito Gennaro; Viglino Paolo

    2007-01-01

    Abstract Background Reduced representations of proteins have been playing a keyrole in the study of protein folding. Many such models are available, with different representation detail. Although the usefulness of many such models for structural bioinformatics applications has been demonstrated in recent years, there are few intermediate resolution models endowed with an energy model capable, for instance, of detecting native or native-like structures among decoy sets. The aim of the present ...

  1. Poster — Thur Eve — 45: Comparison of different Monte Carlo methods of scoring linear energy transfer in modulated proton therapy beams

    International Nuclear Information System (INIS)

    In this work, we demonstrate inconsistencies in commonly used Monte Carlo methods of scoring linear energy transfer (LET) in proton therapy beams. In particle therapy beams, the LET is an important parameter because the relative biological effectiveness (RBE) depends on it. LET is often determined using Monte Carlo techniques. We used a realistic Monte Carlo model of a proton therapy nozzle to score proton LET in spread-out Bragg peak (SOBP) depth-dose distributions. We used three different scoring and calculation techniques to determine average LET at varying depths within a 140 MeV beam with a 4 cm SOBP and a 250 MeV beam with a 10 cm SOBP. These techniques included fluence-weighted (Φ-LET) and dose-weighted average (D-LET) LET calculations from: 1) scored energy spectra converted to LET spectra through a lookup table, 2) directly scored LET spectra and 3) accumulated LET scored ‘on-the-fly’ during simulations. All protons (primary and secondary) were included in the scoring. Φ-LET was found to be less sensitive to changes in scoring technique than D-LET. In addition, the spectral scoring methods were sensitive to low-energy (high-LET) cutoff values in the averaging. Using cutoff parameters chosen carefully for consistency between techniques, we found variations in Φ-LET values of up to 1.6% and variations in D-LET values of up to 11.2% for the same irradiation conditions, depending on the method used to score LET. Variations were largest near the end of the SOBP, where the LET and energy spectra are broader

  2. Prealbumin/CRP Based Prognostic Score, a New Tool for Predicting Metastasis in Patients with Inoperable Gastric Cancer.

    Science.gov (United States)

    Esfahani, Ali; Makhdami, Nima; Faramarzi, Elnaz; Asghari Jafarabadi, Mohammad; Ostadrahimi, Alireza; Ghayour Nahand, Mousa; Ghoreishi, Zohreh

    2016-01-01

    Background. There is a considerable dissimilarity in the survival duration of the patients with gastric cancer. We aimed to assess the systemic inflammatory response (SIR) and nutritional status of these patients before the commencement of chemotherapy to find the appropriate prognostic factors and define a new score for predicting metastasis. Methods. SIR was assessed using Glasgow Prognostic Score (GPS). Then a score was defined as prealbumin/CRP based prognostic score (PCPS) to be compared with GPS for predicting metastasis and nutritional status. Results. 71 patients with gastric cancer were recruited in the study. 87% of patients had malnutrition. There was a statistical difference between those with metastatic (n = 43) and those with nonmetastatic (n = 28) gastric cancer according to levels of prealbumin and CRP; however they were not different regarding patient generated subjective global assessment (PG-SGA) and GPS. The best cut-off value for prealbumin was determined at 0.20 mg/dL and PCPS could predict metastasis with 76.5% sensitivity, 63.6% specificity, and 71.4% accuracy. Metastatic and nonmetastatic gastric cancer patients were different in terms of PCPS (P = 0.005). Conclusion. PCPS has been suggested for predicting metastasis in patients with gastric cancer. Future studies with larger sample size have been warranted. PMID:26904109

  3. Prealbumin/CRP Based Prognostic Score, a New Tool for Predicting Metastasis in Patients with Inoperable Gastric Cancer

    Directory of Open Access Journals (Sweden)

    Ali Esfahani

    2016-01-01

    Full Text Available Background. There is a considerable dissimilarity in the survival duration of the patients with gastric cancer. We aimed to assess the systemic inflammatory response (SIR and nutritional status of these patients before the commencement of chemotherapy to find the appropriate prognostic factors and define a new score for predicting metastasis. Methods. SIR was assessed using Glasgow Prognostic Score (GPS. Then a score was defined as prealbumin/CRP based prognostic score (PCPS to be compared with GPS for predicting metastasis and nutritional status. Results. 71 patients with gastric cancer were recruited in the study. 87% of patients had malnutrition. There was a statistical difference between those with metastatic (n=43 and those with nonmetastatic (n=28 gastric cancer according to levels of prealbumin and CRP; however they were not different regarding patient generated subjective global assessment (PG-SGA and GPS. The best cut-off value for prealbumin was determined at 0.20 mg/dL and PCPS could predict metastasis with 76.5% sensitivity, 63.6% specificity, and 71.4% accuracy. Metastatic and nonmetastatic gastric cancer patients were different in terms of PCPS (P=0.005. Conclusion. PCPS has been suggested for predicting metastasis in patients with gastric cancer. Future studies with larger sample size have been warranted.

  4. Study on Alcoholic Withdrawal Score, with Questionnaire Based Session Conducted on Acute and Chronic Alcoholic Liver Disease Patients

    Directory of Open Access Journals (Sweden)

    Bandi Navyatha

    2016-07-01

    Full Text Available Alcohol liver disease is damage to the Liver and its function due to alcohol abuse. It occurs after years of heavy drinking and by through which cirrhosis can occur and which leads to the final phase of Alcoholic liver disease. It not only occurs in heavy drinkers but also there is a chance of getting liver disease go up the longer of been drinking and more alcohol consumption. A study was observational, prospective and descriptive; and was carried out one hundred and nine patients [n=109] who were with suffering from an Alcoholic liver disease, to determine the alcohol withdrawal score and there symptoms involved after they were kept on alcohol withdrawal therapy. An observational, prospective and randomized study was conducted in the hospital from March 2014-March 2016. Questionnaire based session with 10 scaled questions were framed according to CIWA (assessment and management of alcohol withdrawal and the score was noted with their symptoms occurrence after the alcohol cessation plan. CIWA score with moderate severity were found to be highest. 7 patients out of 33 patients in severe category of CIWA score were admitted in the hospital with alcohol withdrawal syndrome and psychological disturbances. Clinical Institute Withdrawal Assessment of Alcohol Scale (CIWA helps clinicians assess and treat potential alcohol withdrawal.

  5. Advanced Taste Sensors Based on Artificial Lipids with Global Selectivity to Basic Taste Qualities and High Correlation to Sensory Scores

    Directory of Open Access Journals (Sweden)

    Yoshikazu Kobayashi

    2010-04-01

    Full Text Available Effective R&D and strict quality control of a broad range of foods, beverages, and pharmaceutical products require objective taste evaluation. Advanced taste sensors using artificial-lipid membranes have been developed based on concepts of global selectivity and high correlation with human sensory score. These sensors respond similarly to similar basic tastes, which they quantify with high correlations to sensory score. Using these unique properties, these sensors can quantify the basic tastes of saltiness, sourness, bitterness, umami, astringency and richness without multivariate analysis or artificial neural networks. This review describes all aspects of these taste sensors based on artificial lipid, ranging from the response principle and optimal design methods to applications in the food, beverage, and pharmaceutical markets.

  6. MRI assessment of knee osteoarthritis: Knee Osteoarthritis Scoring System (KOSS) - inter-observer and intra-observer reproducibility of a compartment-based scoring system

    International Nuclear Information System (INIS)

    To develop a scoring system for quantifying osteoarthritic changes of the knee as identified by magnetic resonance (MR) imaging, and to determine its inter- and intra-observer reproducibility, in order to monitor medical therapy in research studies. Two independent observers evaluated 25 consecutive MR examinations of the knee in patients with previously defined clinical symptoms and radiological signs of osteoarthritis. We acquired on a 1.5 T system: coronal and sagittal proton density- and T2-weighted dual spin echo (SE) images, sagittal three-dimensional T1-weighted gradient echo (GE) images with fat suppression, and axial dual turbo SE images with fat suppression. Images were scored for the presence of cartilaginous lesions, osteophytes, subchondral cysts, bone marrow edema, and for meniscal abnormalities. Presence and size of effusion, synovitis and Baker's cyst were recorded. All parameters were ranked on a previously defined, semiquantitative scale, reflecting increasing severity of findings. Kappa, weighted kappa and intraclass correlation coefficient (ICC) were used to determine inter- and intra-observer variability. Inter-observer reproducibility was good (ICC value 0.77). Inter- and intra-observer reproducibility for individual parameters was good to very good (inter-observer ICC value 0.63-0.91; intra-observer ICC value 0.76-0.96). The presented comprehensive MR scoring system for osteoarthritic changes of the knee has a good to very good inter-observer and intra-observer reproducibility. Thus the score form with its definitions can be used for standardized assessment of osteoarthritic changes to monitor medical therapy in research studies. (orig.)

  7. Performance Assessment of the Food Industry of Tehran Stock Exchange Based on Balanced Score Card (BSC) Technique

    OpenAIRE

    Morteza Asadi; Javad Mehrabi; Saharnaz Mohseni; Mohammad Hasan Tanhaei

    2013-01-01

    Major objective of the present paper was to study the role of balanced score card regarding performance assessment of companies listed in food and beverage industry in the stock exchange. This survey is descriptive and is regarded as a quasi-experimental research plan (Ex-Post design). The statistical population included 200 managers and research sample consisted of 99 persons based on Cochran formula. Questionnaire was used for data collection. Frequency tables and appropriate diagrams were ...

  8. The CAIDE Dementia Risk Score App: The development of an evidence-based mobile application to predict the risk of dementia

    OpenAIRE

    Sindi, Shireen; Calov, Elisabeth; Fokkens, Jasmine; Ngandu, Tiia; Soininen, Hilkka; Tuomilehto, Jaakko; Kivipelto, Miia

    2015-01-01

    Background The CAIDE (Cardiovascular Risk Factors, Aging, and Incidence of Dementia) Dementia Risk Score is a validated tool to predict late-life dementia risk (20 years later), based on midlife vascular risk factors. The goal was to render this prediction tool widely accessible. Methods The CAIDE Risk Score (mobile application) App was developed based on the CAIDE Dementia Risk Score, involving information on age, educational level, hypertension, hypercholesterolemia, obesity, and physical i...

  9. Scoring tail damage in pigs: an evaluation based on recordings at Swedish slaughterhouses

    Directory of Open Access Journals (Sweden)

    Keeling Linda J

    2012-05-01

    Full Text Available Abstract Background There is increasing interest in recording tail damage in pigs at slaughter to identify problem farms for advisory purposes, but also for benchmarking within and between countries as part of systematic monitoring of animal welfare. However, it is difficult to draw conclusions when comparing prevalence’s between studies and countries partly due to differences in management (e.g. differences in tail docking and enrichment routines and partly due to differences in the definition of tail damage. Methods Tail damage and tail length was recorded for 15,068 pigs slaughtered during three and four consecutive days at two slaughterhouses in Sweden. Tail damage was visually scored according to a 6-point scale and tail length was both visually scored according to a 5-point scale and recorded as tail length in centimetres for pigs with injured or shortened tails. Results The total prevalence of injury or shortening of the tail was 7.0% and 7.2% in slaughterhouse A and B, respectively. When only considering pigs with half or less of the tail left, these percentages were 1.5% and 1.9%, which is in line with the prevalence estimated from the routine recordings at slaughter in Sweden. A higher percentage of males had injured and/or shortened tails, and males had more severely bitten tails than females. Conclusions While the current method to record tail damage in Sweden was found to be reliable as a method to identify problem farms, it clearly underestimates the actual prevalence of tail damage. For monitoring and benchmarking purposes, both in Sweden and internationally, we propose that a three graded scale including both old and new tail damage would be more appropriate. The scale consists of one class for no tail damage, one for mild tail damage (injured or shortened tail with more than half of the tail remaining and one for severe tail damage (half or less of the tail remaining.

  10. Prognostic value of scores based on malnutrition or systemic inflammatory response in patients with metastatic or recurrent gastric cancer.

    Science.gov (United States)

    Sachlova, Milana; Majek, Ondrej; Tucek, Stepan

    2014-01-01

    Cancer patients are frequently affected by malnutrition and weight loss, which affects their prognosis, length of hospital stay, health care costs, quality of life and survival. Our aim was to assess the prognostic value of different scores based on malnutrition or systemic inflammatory response in 91 metastatic or recurrent gastric cancer patients considered for palliative chemotherapy at the Masaryk Memorial Cancer Institute. We investigated their overall survival according to the following measures: Onodera's Prognostic Nutritional Index (OPNI), Glasgow Prognostic Score (GPS), nutritional risk indicator (NRI), Cancer Cachexia Study Group (CCSG), as previously defined, and a simple preadmission weight loss. The OPNI, GPS, and CCSG provided very significant prognostic values for survival (log-rank test P value evaluation of patients' prognosis and should be part of a routine evaluation of patients to provide a timely nutrition support. PMID:25356861

  11. The relationship between observer-based toxicity scoring and patient assessed symptom severity after treatment for head and neck cancer. A correlative cross sectional study of the DAHANCA toxicity scoring system and the EORTC quality of life questionnaires

    International Nuclear Information System (INIS)

    Background and purpose: Morbidity is an important issue in cancer research. The observer-based toxicity scoring system used by DAHANCA (the Danish head and neck cancer study group) has proved itself sensitive to differences in toxicity in a large randomised study, but like other toxicity scoring systems it has not been formally validated. Conversely, the EORTC quality of life questionnaire (QLQ) has been validated as a tool for collecting information about the consequences of disease and treatment on the well being of cancer patients. The purpose of this study was to examine the relationship between the two methods of side effect recording. Patients and methods: One hundred and sixteen recurrence free patients with laryngeal (n=44), pharyngeal (n=34) and oral cavity (n=38) cancer attending follow-up after radiotherapy (n=83) or surgery (n=33) completed EORTC C30, the core questionnaire concerning general symptoms and function and EORTC H and N35 the head and neck specific questionnaire. The attending physicians in the follow-up clinic evaluated and recorded DAHANCA toxicity scores on the same patients. Results: The DAHANCA toxicity scoring system and the EORTC QLQ correlated with several clinical endpoints. The conceptually similar endpoints of the two methods correlated significantly. The objective endpoints of the DAHANCA scoring system were only correlated with quality of life endpoints to a very low degree. The DAHANCA toxicity scores had a low sensitivity (0.48-0.74) in detecting equivalent subjective complaints from the questionnaires and the observer-based scoring system severely underestimated patient complaints. A specific patient group where the DAHANCA score had a higher tendency to fail could not be detected. Conclusion: The DAHANCA toxicity score is an effective instrument in assessing objective treatment induced toxicity in head and neck cancer patients but insensitive and non-specific with regard to patient assessed subjective endpoints. This

  12. Credit scoring

    OpenAIRE

    Sánchez Bilbao, Pablo

    2015-01-01

    RESUMEN: El credit scoring es un sistema de modelos de decisión a través del cual se calcula la probabilidad de que un sujeto sea capaz de devolver o no un crédito comercial. Este trabajo realiza una simulación de este modelo con la intención de familiarizarse con el funcionamiento del mismo, así como con el marco teórico que este conlleva. El uso del credit scoring da respuesta a un problema generalizado en las entidades financieras como es la correcta estimación y valoración del riesg...

  13. Development of a Food Group-Based Diet Score and Its Association with Bone Mineral Density in the Elderly: The Rotterdam Study

    OpenAIRE

    Ester A.L. de Jonge; Kiefte-de Jong, Jessica C.; de Groot, Lisette C. P. G. M.; Trudy Voortman; Josje D. Schoufour; M Carola Zillikens; Albert Hofman; Uitterlinden, André G.; Franco, Oscar H.; Fernando Rivadeneira

    2015-01-01

    No diet score exists that summarizes the features of a diet that is optimal for bone mineral density (BMD) in the elderly. Our aims were (a) to develop a BMD-Diet Score reflecting a diet that may be beneficial for BMD based on the existing literature, and (b) to examine the association of the BMD-Diet Score and the Healthy Diet Indicator, a score based on guidelines of the World Health Organization, with BMD in Dutch elderly participating in a prospective cohort study, the Rotterdam Study (n ...

  14. Score Correlation

    Czech Academy of Sciences Publication Activity Database

    Fabián, Zdeněk

    2010-01-01

    Roč. 20, č. 6 (2010), s. 793-798. ISSN 1210-0552 R&D Projects: GA ČR GA205/09/1079 Institutional research plan: CEZ:AV0Z10300504 Keywords : score function * correlation * rank correlation coefficient * heavy tails Subject RIV: BB - Applied Statistics, Operational Research Impact factor: 0.511, year: 2010

  15. A new approach for automatic sleep scoring: Combining Taguchi based complex-valued neural network and complex wavelet transform.

    Science.gov (United States)

    Peker, Musa

    2016-06-01

    Automatic classification of sleep stages is one of the most important methods used for diagnostic procedures in psychiatry and neurology. This method, which has been developed by sleep specialists, is a time-consuming and difficult process. Generally, electroencephalogram (EEG) signals are used in sleep scoring. In this study, a new complex classifier-based approach is presented for automatic sleep scoring using EEG signals. In this context, complex-valued methods were utilized in the feature selection and classification stages. In the feature selection stage, features of EEG data were extracted with the help of a dual tree complex wavelet transform (DTCWT). In the next phase, five statistical features were obtained. These features are classified using complex-valued neural network (CVANN) algorithm. The Taguchi method was used in order to determine the effective parameter values in this CVANN. The aim was to develop a stable model involving parameter optimization. Different statistical parameters were utilized in the evaluation phase. Also, results were obtained in terms of two different sleep standards. In the study in which a 2nd level DTCWT and CVANN hybrid model was used, 93.84% accuracy rate was obtained according to the Rechtschaffen & Kales (R&K) standard, while a 95.42% accuracy rate was obtained according to the American Academy of Sleep Medicine (AASM) standard. Complex-valued classifiers were found to be promising in terms of the automatic sleep scoring and EEG data. PMID:26787511

  16. Psychometric Properties of Scores from the Web-based LibQUAL+ Study of Perceptions of Library Service Quality.

    Science.gov (United States)

    Cook, Colleen; Thompson, Bruce

    2001-01-01

    Investigated the psychometric integrity of scores from the LibQUAL+ evaluation of perceived library service quality conducted by ARL (Association of Research Libraries). Examines score structure, score reliability, score correlation and concurrent validity coefficients, scale means, and scale standardized norms, and considers the potential of the…

  17. Score System Study for Hand-Extended Noodle Quality Based on HMW-GS Index in Wheat Flour

    Institute of Scientific and Technical Information of China (English)

    KANG Zhi-yu; WANG Jian-jun; SHANG Xun-wu

    2007-01-01

    Hand-extended noodle, a special kind of noodle, requires particular quality flour to make it. High molecular weight glutenin subunits (HMW-GS) in wheat are important protein subunits, which affect flour quality. To improve breeding and selection efficiency of wheat varieties which are used in making hand-extended noodle, 100 spring wheat varieties were selected to study the importance of HMW-GS on noodle quality score indexes such as color, appearance, taste agreeability, toughness, stickiness, smoothness, taste, and total score, through methods of quantity theory and statistic evaluation. It was shown that the hand-extended noodle quality score of HMW-GS 1, 2*, N, 7, 7 + 8, 17 + 18, 22, 2 + 10, 2 +11, 2+ 12, 5 + 10, and 10 was 5.40, 5.35, 0, 2.55, 2.56, 9.19, 0.05, 0.15, 1.49, 1.14, 10.00, and 5.14, respectively. The score system for hand-extended noodle quality based on HMW-GS index included eight multiple linear regression equations (R2 > 0.98).Hence, using the HMW-GS composition, the eight hand-extended noodle quality indexes would be forecasted exactly.Results indicated that ideal subunit compositions of HMW-GS for this special usage were composition 1, 17 + 18, 5 + 10, or composition 2*, 17 + 18, 5 + 10. This standard could be used on variety selection in the early generation of breeding crosses. HMW-GS 2 + 10, 2 + 11, and 2 + 12 were the least desirable subunits for hand-extended noodle, which should be avoided in wheat variety selection aimed for hand-extended noodle flour use.

  18. Species Identification in Malaise Trap Samples by DNA Barcoding Based on NGS Technologies and a Scoring Matrix

    Science.gov (United States)

    Morinière, Jérôme; Cancian de Araujo, Bruno; Hausmann, Axel; Balke, Michael; Hendrich, Lars; Doczkal, Dieter; Arvidsson, Samuel; Haszprunar, Gerhard

    2016-01-01

    The German Barcoding initiatives BFB and GBOL have generated a reference library of more than 16,000 metazoan species, which is now ready for applications concerning next generation molecular biodiversity assessments. To streamline the barcoding process, we have developed a meta-barcoding pipeline: We pre-sorted a single malaise trap sample (obtained during one week in August 2014, southern Germany) into 12 arthropod orders and extracted DNA from pooled individuals of each order separately, in order to facilitate DNA extraction and avoid time consuming single specimen selection. Aliquots of each ordinal-level DNA extract were combined to roughly simulate a DNA extract from a non-sorted malaise sample. Each DNA extract was amplified using four primer sets targeting the CO1-5’ fragment. The resulting PCR products (150-400bp) were sequenced separately on an Illumina Mi-SEQ platform, resulting in 1.5 million sequences and 5,500 clusters (coverage ≥10; CD-HIT-EST, 98%). Using a total of 120,000 DNA barcodes of identified, Central European Hymenoptera, Coleoptera, Diptera, and Lepidoptera downloaded from BOLD we established a reference sequence database for a local CUSTOM BLAST. This allowed us to identify 529 Barcode Index Numbers (BINs) from our sequence clusters derived from pooled Malaise trap samples. We introduce a scoring matrix based on the sequence match percentages of each amplicon in order to gain plausibility for each detected BIN, leading to 390 high score BINs in the sorted samples; whereas 268 of these high score BINs (69%) could be identified in the combined sample. The results indicate that a time consuming presorting process will yield approximately 30% more high score BINs compared to the non-sorted sample in our case. These promising results indicate that a fast, efficient and reliable analysis of next generation data from malaise trap samples can be achieved using this pipeline. PMID:27191722

  19. A scoring system based on artificial neural network for predicting 10-year survival in stage II A colon cancer patients after radical surgery

    Science.gov (United States)

    Jiang, Wu; Lu, Shi-Xun; Lu, Zhen-Hai; Li, Pei-Xing; Yun, Jing-Ping; Zhang, Rong-Xin; Pan, Zhi-Zhong; Wan, De-Sen

    2016-01-01

    Nearly 20% patients with stage II A colon cancer will develop recurrent disease post-operatively. The present study aims to develop a scoring system based on Artificial Neural Network (ANN) model for predicting 10-year survival outcome. The clinical and molecular data of 117 stage II A colon cancer patients from Sun Yat-sen University Cancer Center were used for training set and test set; poor pathological grading (score 49), reduced expression of TGFBR2 (score 33), over-expression of TGF-β (score 45), MAPK (score 32), pin1 (score 100), β-catenin in tumor tissue (score 50) and reduced expression of TGF-β in normal mucosa (score 22) were selected as the prognostic risk predictors. According to the developed scoring system, the patients were divided into 3 subgroups, which were supposed with higher, moderate and lower risk levels. As a result, for the 3 subgroups, the 10-year overall survival (OS) rates were 16.7%, 62.9% and 100% (P < 0.001); and the 10-year disease free survival (DFS) rates were 16.7%, 61.8% and 98.8% (P < 0.001) respectively. It showed that this scoring system for stage II A colon cancer could help to predict long-term survival and screen out high-risk individuals for more vigorous treatment. PMID:27008710

  20. Internationally comparable diagnosis-specific survival probabilities for calculation of the ICD-10-based Injury Severity Score

    DEFF Research Database (Denmark)

    Gedeborg, R.; Warner, M.; Chen, L. H.;

    2014-01-01

    BACKGROUND: The International Statistical Classification of Diseases, 10th Revision (ICD-10) -based Injury Severity Score (ICISS) performs well but requires diagnosis-specific survival probabilities (DSPs), which are empirically derived, for its calculation. The objective was to examine if DSPs...... country's own DSPs for ICISS calculation, the pooled DSPs resulted in somewhat reduced discrimination in predicting mortality (difference in c statistic varied from 0.006 to 0.04). Calibration was generally good when the predicted mortality risk was less than 20%. When Danish and Swedish data were used...

  1. Meaning-Based Scoring: A Systemic Functional Linguistics Model for Automated Test Tasks

    Science.gov (United States)

    Gleason, Jesse

    2014-01-01

    Communicative approaches to language teaching that emphasize the importance of speaking (e.g., task-based language teaching) require innovative and evidence-based means of assessing oral language. Nonetheless, research has yet to produce an adequate assessment model for oral language (Chun 2006; Downey et al. 2008). Limited by automatic speech…

  2. Development of a model based scoring system for diagnosis of canine disseminated intravascular coagulation with independent assessment of sensitivity and specificity

    DEFF Research Database (Denmark)

    Wiinberg, Bo; Jensen, Asger Lundorff; Johansson, Per Ingemar; Kjelgaard-Hansen, Mads; Rozanski, Elizabeth; Tranholm, Mikael; Kristensen, Annemarie Thuri

    2010-01-01

    A template for a scoring system for disseminated intravascular coagulation (DIC) in humans has been proposed by the International Society on Thrombosis and Haemostasis (ISTH). The objective of this study was to develop and validate a similar objective scoring system based on generally available c...

  3. Population-based study of ABCD2 score, carotid stenosis, and atrial fibrillation for early stroke prediction after transient ischemic attack: the North Dublin TIA study.

    LENUS (Irish Health Repository)

    Sheehan, Orla C

    2010-05-01

    Transient ischemic attack (TIA) etiologic data and the ABCD(2) score may improve early stroke risk prediction, but studies are required in population-based cohorts. We investigated the external validity of the ABCD(2) score, carotid stenosis, and atrial fibrillation for prediction of early recurrent stroke after TIA.

  4. Population-standardized genetic risk score: the SNP-based method of choice for inherited risk assessment of prostate cancer

    Directory of Open Access Journals (Sweden)

    Carly A Conran

    2016-01-01

    Full Text Available Several different approaches are available to clinicians for determining prostate cancer (PCa risk. The clinical validity of various PCa risk assessment methods utilizing single nucleotide polymorphisms (SNPs has been established; however, these SNP-based methods have not been compared. The objective of this study was to compare the three most commonly used SNP-based methods for PCa risk assessment. Participants were men (n = 1654 enrolled in a prospective study of PCa development. Genotypes of 59 PCa risk-associated SNPs were available in this cohort. Three methods of calculating SNP-based genetic risk scores (GRSs were used for the evaluation of individual disease risk such as risk allele count (GRS-RAC, weighted risk allele count (GRS-wRAC, and population-standardized genetic risk score (GRS-PS. Mean GRSs were calculated, and performances were compared using area under the receiver operating characteristic curve (AUC and positive predictive value (PPV. All SNP-based methods were found to be independently associated with PCa (all P 0.05 for comparisons between the three methods, and all three SNP-based methods had a significantly higher AUC than family history (all P < 0.05. Results from this study suggest that while the three most commonly used SNP-based methods performed similarly in discriminating PCa from non-PCa at the population level, GRS-PS is the method of choice for risk assessment at the individual level because its value (where 1.0 represents average population risk can be easily interpreted regardless of the number of risk-associated SNPs used in the calculation.

  5. Risk-based priority scoring for Brookhaven National Laboratory environmental restoration programs

    International Nuclear Information System (INIS)

    This report describes the process of estimating the risk associated with environmental restoration programs under the Brookhaven National Laboratory Office of Environmental Restoration. The process was part of an effort across all Department of Energy facilities to provide a consistent framework to communicate risk information about the facilities to senior managers in the DOE Office of Environmental Management to foster understanding of risk activities across programs. the risk evaluation was a qualitative exercise. Categories considered included: Public health and safety; site personnel safety and health; compliance; mission impact; cost-effective risk management; environmental protection; inherent worker risk; environmental effects of clean-up; and social, cultural, political, and economic impacts

  6. Discriminate protein decoys from native by using a scoring function based on ubiquitous Phi and Psi angles computed for all atom.

    Science.gov (United States)

    Mishra, Avdesh; Iqbal, Sumaiya; Hoque, Md Tamjidul

    2016-06-01

    The success of solving the protein folding and structure prediction problems in molecular and structural biology relies on an accurate energy function. With the rapid advancement in the computational biology and bioinformatics fields, there is a growing need of solving unknown fold and structure faster and thus an accurate energy function is indispensable. To address this need, we develop a new potential function, namely 3DIGARS3.0, which is a linearly weighted combination of 3DIGARS, mined accessible surface area (ASA) and ubiquitously computed Phi (uPhi) and Psi (uPsi) energies - optimized by a Genetic Algorithm (GA). We use a dataset of 4332 protein-structures to generate uPhi and uPsi based score libraries to be used within the core 3DIGARS method. The optimized weight of each component is obtained by applying Genetic Algorithm based optimization on three challenging decoy sets. The improved 3DIGARS3.0 outperformed state-of-the-art methods significantly based on a set of independent test datasets. PMID:27029514

  7. Pre-Service Teachers' Constructivist Teaching Scores Based on Their Learning Styles

    Science.gov (United States)

    Kablan, Zeynel; Kaya, Sibel

    2014-01-01

    This study examined the relationship between pre-service teachers' constructivist teaching and their learning styles based on Kolb's Experiential Learning Theory. The Learning Styles Inventory-3 was administered at the beginning of the semester to determine preferred learning style. The Constructivist Teaching Evaluation Form was filled…

  8. Grading as a Reform Effort: Do Standards-Based Grades Converge with Test Scores?

    Science.gov (United States)

    Welsh, Megan E.; D'Agostino, Jerome V.; Kaniskan, Burcu

    2013-01-01

    Standards-based progress reports (SBPRs) require teachers to grade students using the performance levels reported by state tests and are an increasingly popular report card format. They may help to increase teacher familiarity with state standards, encourage teachers to exclude nonacademic factors from grades, and/or improve communication with…

  9. IDENTIFYING SIMILAR WEB PAGES BASED ON AUTOMATED AND USER PREFERENCE VALUE USING SCORING METHODS

    OpenAIRE

    Gandhimathi K; Vijaya MS

    2013-01-01

    A World Wide Web (WWW) is a system of interlinked hypertext documents accessed via internet. The web structure mining is based on the graph structure of hyperlinks and it extracts the useful information from structure of web data. Web structure mining aims to generate structural summary about web sites and web pages. Identifying the web community is one of the goal in web structure mining. This paper presents an alternate web community identification approach to detect the similar...

  10. The Patient- And Nutrition-Derived Outcome Risk Assessment Score (PANDORA: Development of a Simple Predictive Risk Score for 30-Day In-Hospital Mortality Based on Demographics, Clinical Observation, and Nutrition.

    Directory of Open Access Journals (Sweden)

    Michael Hiesmayr

    Full Text Available To develop a simple scoring system to predict 30 day in-hospital mortality of in-patients excluding those from intensive care units based on easily obtainable demographic, disease and nutrition related patient data.Score development with general estimation equation methodology and model selection by P-value thresholding based on a cross-sectional sample of 52 risk indicators with 123 item classes collected with questionnaires and stored in an multilingual online database.Worldwide prospective cross-sectional cohort with 30 day in-hospital mortality from the nutritionDay 2006-2009 and an external validation sample from 2012.We included 43894 patients from 2480 units in 32 countries. 1631(3.72% patients died within 30 days in hospital. The Patient- And Nutrition-Derived Outcome Risk Assessment (PANDORA score predicts 30-day hospital mortality based on 7 indicators with 31 item classes on a scale from 0 to 75 points. The indicators are age (0 to 17 points, nutrient intake on nutritionDay (0 to 12 points, mobility (0 to 11 points, fluid status (0 to 10 points, BMI (0 to 9 points, cancer (9 points and main patient group (0 to 7 points. An appropriate model fit has been achieved. The area under the receiver operating characteristic curve for mortality prediction was 0.82 in the development sample and 0.79 in the external validation sample.The PANDORA score is a simple, robust scoring system for a general population of hospitalised patients to be used for risk stratification and benchmarking.

  11. Development of a biological dosimeter for translocation scoring based on two-color fluorescence in situ hybridization of chromosome subsets

    International Nuclear Information System (INIS)

    Recently fluorescence in situ hybridization protocols have been developed which allow the paining of individual chromosomes using DNA-libraries from sorted human chromosomes. This approach has the particular advantage that radiation induced chromosome translocations can be easily detected, if chromosomes of distinctly different colors take part in the translocation event. To enhance the sensitivity of this approach two metaphase chromosome subsets A and B (A: chromosome 1, 2, 4, 8, 16; B: 3, 5, 9, 10, 13) were simultaneously painted in green and red color. Counterstaining of the chromosomes with DAPI resulted in a third subset which exhibited blue fluorescence only. Green-red, green-blue and red-blue translocation chromosomes could be easily detected after irradiation of lymphocyte cultures with 137Cs-γ-rays. Analyses of painted chromosomes can be combined with conventional GTG-banding analyses. This new biological dosimeter should become useful to monitor both long term effects of single irradiation events and the cumulative effects of multiple or chronic irradiation exposure. In contrast to translocation scoring based on the analysis of banded chromosomes, this new approach has the particular advantage that a rapid, automated scoring of translocations can now be envisaged. (author)

  12. A new extranodal scoring system based on the prognostically relevant extranodal sites in diffuse large B-cell lymphoma, not otherwise specified treated with chemoimmunotherapy.

    Science.gov (United States)

    Hwang, Hee Sang; Yoon, Dok Hyun; Suh, Cheolwon; Huh, Jooryung

    2016-08-01

    Extranodal involvement is a well-known prognostic factor in patients with diffuse large B-cell lymphomas (DLBCL). Nevertheless, the prognostic impact of the extranodal scoring system included in the conventional international prognostic index (IPI) has been questioned in an era where rituximab treatment has become widespread. We investigated the prognostic impacts of individual sites of extranodal involvement in 761 patients with DLBCL who received rituximab-based chemoimmunotherapy. Subsequently, we established a new extranodal scoring system based on extranodal sites, showing significant prognostic correlation, and compared this system with conventional scoring systems, such as the IPI and the National Comprehensive Cancer Network-IPI (NCCN-IPI). An internal validation procedure, using bootstrapped samples, was also performed for both univariate and multivariate models. Using multivariate analysis with a backward variable selection, we found nine extranodal sites (the liver, lung, spleen, central nervous system, bone marrow, kidney, skin, adrenal glands, and peritoneum) that remained significant for use in the final model. Our newly established extranodal scoring system, based on these sites, was better correlated with patient survival than standard scoring systems, such as the IPI and the NCCN-IPI. Internal validation by bootstrapping demonstrated an improvement in model performance of our modified extranodal scoring system. Our new extranodal scoring system, based on the prognostically relevant sites, may improve the performance of conventional prognostic models of DLBCL in the rituximab era and warrants further external validation using large study populations. PMID:27167532

  13. A new, preoperative, MRI-based scoring system for diagnosing malignant axillary lymph nodes in women evaluated for breast cancer

    International Nuclear Information System (INIS)

    Objective: Malignant axillary lymph nodes are an important predictor for breast cancer recurrence, but invasive dissection or biopsy is required for the diagnosis. We determined whether and how malignant nodes could be diagnosed preoperatively with magnetic resonance (MR) imaging. Materials and methods: We obtained MR images of all women evaluated for breast cancer at the Sun Yat-Sen University Cancer Center in 2010 and correlated the image characteristics of each axillary node with the pathologic diagnosis of the same node. Results: We analyzed 251 nodes (117 benign; 134 malignant) from 136 women (mean age, 44 years; range, 20–67). Mean diameter of the nodes was 18 mm (range, 5–58 mm). With pathologic diagnosis as the reference standard, MRI-based interpretations were 66.4% sensitive, 94% specific, and 79% accurate. Diameter, pathologic type, apparent diffusion coefficient value (ADC, b = 500 and 800), time-intensity curve (TIC) type of breast tumors correlated with node metastasis; ADC value (b = 500 and 800), TIC type, early enhancement rate, long-axis, short-axis, shape, margin and the location of nodes correlated with node metastasis (P < 0.001 for all). Tumor immunohistochemistry results for estrogen receptors, progesterone receptors, c-erbB-2, vascular endothelial growth factor, and Ki67 were not. An MRI-based lymph node scoring system based on these correlations had a specificity of 91%, a sensitivity of 93%, and an area under the ROC curve of 0.95 (P < 0.001). Conclusion: Metastatic axillary lymph nodes can be accurately diagnosed by MR in women with early breast cancer preoperatively and non-invasively. The scoring system appears to be superior to current methods

  14. Comparison of T-score values obtained by ultrasound osteodensitometry of calcaneus and by dual-energy x-ray absorptiometry scan

    Directory of Open Access Journals (Sweden)

    Hadžiavdić Aleksandra

    2015-01-01

    Full Text Available Introduction. Osteoporosis is the most frequent metabolic disease of bones. Early detection of pathological loss of bone mineral density represents the first step in prevention, treatment and rehabilitation of osteoporosis. This study was aimed at establishing the correlation of T-score values obtained by ultrasound osteodensitometry of calcaneus with dual-energy x-ray absorptiometry scan. Material and Methods. The study was conducted on the sample of 569 female patients from September 13, 2010 to March 10, 2011. Measurement was made with ultrasound osteodensitometry of ACHILLES make. Quantitative ultrasound method revealed that 77 female patients had a lower value of T-score (osteopenia with risk factors or osteoporosis and they were referred to T-score measurement with dual-energy x-ray absorptiometry scan. Dual-energy x-ray absorptiometry scanning was performed using LUNAR DPX scanner and 49 female patients were examined. Results. It was concluded that there was no statistically significant difference between T-score values obtained by quantitative ultrasound and dual-energy x-ray absorptiometry scanning. Conclusion. According to this study, it is necessary to provide a greater number of scanners for ultrasound osteodensitometry of calcaneus in order to secure prevention and to refer the patients to further diagnosing on time.

  15. Investigating the relationship between outsourcing and performance based on Balanced Score Card (Case study Ilam Post Office

    Directory of Open Access Journals (Sweden)

    Karam Khalili

    2014-01-01

    Full Text Available Today, outsourcing can play a crucial role in satisfying customers and meeting their requirements; therefore post office has devoted some of its services and supports for improving the performance, reducing the expenses, and modifying the organizational structure. The main purpose of this study is to investigate the relationship between outsourcing and the performance based on Balanced Score Card (Ilam Post Office in 2013. This study was a descriptive-survey and it utilized a questionnaire for collecting data. SPSS software was used to analyze the data. Useable data were gathered from 18 managers and assistants. T-student and correlation method was used for data analysis. The results showed that there are a strong and positive relationship between outsourcing post office activities and performance management in three aspects of financial, customers and internal processes; however there was a positive and weak relationship between the aspect of learning and outsourcing.

  16. Reproducibility of trabecular bone score with different scan modes using dual-energy X-ray absorptiometry: a phantom study

    Energy Technology Data Exchange (ETDEWEB)

    Bandirali, Michele; Messina, Carmelo [Universita degli Studi di Milano, Scuola di Specializzazione in Radiodiagnostica, Milano (Italy); Di Leo, Giovanni [Unita di Radiologia, IRCCS Policlinico San Donato, San Donato Milanese (Italy); Pastor Lopez, Maria Juana; Ulivieri, Fabio M. [Servizio di Medicina Nucleare, Ospedale Maggiore, Mineralometria Ossea Computerizzata e Ambulatorio Malattie Metabolismo Minerale e Osseo, Milano (Italy); Mai, Alessandro [Universita degli Studi di Milano, Tecniche di Radiologia Medica, per Immagini e Radioterapia, Milano (Italy); Sardanelli, Francesco [Unita di Radiologia, IRCCS Policlinico San Donato, San Donato Milanese (Italy); Universita degli Studi di Milano, Dipartimento di Scienze Biomediche per la Salute, San Donato Milanese (Italy)

    2014-08-12

    The trabecular bone score (TBS) accounts for the bone microarchitecture and is calculated on dual-energy X-ray absorptiometry (DXA). We estimated the reproducibility of the TBS using different scan modes compared to the reproducibility bone mineral density (BMD). A spine phantom was used with a Hologic QDR-Discovery A densitometer. For each scan mode [fast array, array, high definition (HD)], 25 scans were automatically performed without phantom repositioning; a further 25 scans were performed with phantom repositioning. For each scan, the TBS was obtained. The coefficient of variation (CoV) was calculated as the ratio between standard deviation and mean; percent least significant change (LSC%) as 2.8 x CoV; reproducibility as the complement to 100 % of LSC%. Differences among scan modes were assessed using ANOVA. Without phantom repositioning, the mean TBS (mm{sup -1}) was: 1.352 (fast array), 1.321 (array), and 1.360 (HD); with phantom repositioning, it was 1.345, 1.332, and 1.362, respectively. Reproducibility of the TBS without phantom repositioning was 97.7 % (fast array), 98.3 % (array), and 98.2 % (HD); with phantom repositioning, it was 97.9 %, 98.7 %, and 98.4 %, respectively. LSC% was ≤2.26 %. Differences among scan modes were all statistically significant (p ≤ 0.019). Reproducibility of BMD was 99.1 % with all scan modes, while LSC% was from 0.86 % to 0.91 %. Reproducibility error of the TBS was 2-3-fold higher than that of BMD. Although statistically significant, differences in TBS among scan modes were within the highest LSC%. Thus, the three scan modes can be considered interchangeable. (orig.)

  17. The Healthy Weights Initiative: a community-based obesity reduction program with positive impact on depressed mood scores

    Science.gov (United States)

    Lemstra, Mark Edgar; Rogers, Marla Rochelle

    2016-01-01

    Objectives The risk for many chronic diseases increases with obesity. In addition to these, the risk for depression also increases. Exercise interventions for weight loss among those who are not overweight or obese have shown a moderate effect on depression, but few studies have looked at those with obesity. The objectives of this study were to determine 1) the prevalence of depressed mood in obese participants as determined by the Beck Depression Inventory II at baseline and follow-up; 2) the change in depressed mood between those who completed the program and those who did not; and 3) the differences between those whose depressed mood was alleviated after the program and those who continued to have depressed mood. Methods Depressed mood scores were calculated at baseline and follow-up for those who completed the program and for those who quit. Among those who completed the program, chi-squares were used to determine the differences between those who no longer had depressed mood and those who still had depressed mood at the end of the program, and regression analysis was used to determine the independent risk factors for still having depressed mood at program completion. Results Depressed mood prevalence decreased from 45.7% to 11.7% (P<0.000) from baseline to follow-up among those who completed the program and increased from 44.8% to 55.6% (P<0.000) among those who quit. After logistic regression, a score of <40 in general health increased the risk of still having depressed mood upon program completion (odds ratio [OR] 3.39; 95% CI 1.18–9.72; P=0.023). Conclusion Treating depressed mood among obese adults through a community-based, weight-loss program based on evidence may be an adjunct to medical treatment. More research is needed.

  18. Modeling complexity in pathologist workload measurement: the Automatable Activity-Based Approach to Complexity Unit Scoring (AABACUS).

    Science.gov (United States)

    Cheung, Carol C; Torlakovic, Emina E; Chow, Hung; Snover, Dale C; Asa, Sylvia L

    2015-03-01

    Pathologists provide diagnoses relevant to the disease state of the patient and identify specific tissue characteristics relevant to response to therapy and prognosis. As personalized medicine evolves, there is a trend for increased demand of tissue-derived parameters. Pathologists perform increasingly complex analyses on the same 'cases'. Traditional methods of workload assessment and reimbursement, based on number of cases sometimes with a modifier (eg, the relative value unit (RVU) system used in the United States), often grossly underestimate the amount of work needed for complex cases and may overvalue simple, small biopsy cases. We describe a new approach to pathologist workload measurement that aligns with this new practice paradigm. Our multisite institution with geographically diverse partner institutions has developed the Automatable Activity-Based Approach to Complexity Unit Scoring (AABACUS) model that captures pathologists' clinical activities from parameters documented in departmental laboratory information systems (LISs). The model's algorithm includes: 'capture', 'export', 'identify', 'count', 'score', 'attribute', 'filter', and 'assess filtered results'. Captured data include specimen acquisition, handling, analysis, and reporting activities. Activities were counted and complexity units (CUs) generated using a complexity factor for each activity. CUs were compared between institutions, practice groups, and practice types and evaluated over a 5-year period (2008-2012). The annual load of a clinical service pathologist, irrespective of subspecialty, was ∼40,000 CUs using relative benchmarking. The model detected changing practice patterns and was appropriate for monitoring clinical workload for anatomical pathology, neuropathology, and hematopathology in academic and community settings, and encompassing subspecialty and generalist practices. AABACUS is objective, can be integrated with an LIS and automated, is reproducible, backwards compatible

  19. Impact on house staff evaluation scores when changing from a Dreyfus- to a Milestone-based evaluation model: one internal medicine residency program's findings

    Directory of Open Access Journals (Sweden)

    Karen A. Friedman

    2014-11-01

    Full Text Available Purpose: As graduate medical education (GME moves into the Next Accreditation System (NAS, programs must take a critical look at their current models of evaluation and assess how well they align with reporting outcomes. Our objective was to assess the impact on house staff evaluation scores when transitioning from a Dreyfus-based model of evaluation to a Milestone-based model of evaluation. Milestones are a key component of the NAS. Method: We analyzed all end of rotation evaluations of house staff completed by faculty for academic years 2010–2011 (pre-Dreyfus model and 2011–2012 (post-Milestone model in one large university-based internal medicine residency training program. Main measures included change in PGY-level average score; slope, range, and separation of average scores across all six Accreditation Council for Graduate Medical Education (ACGME competencies. Results: Transitioning from a Dreyfus-based model to a Milestone-based model resulted in a larger separation in the scores between our three post-graduate year classes, a steeper progression of scores in the PGY-1 class, a wider use of the 5-point scale on our global end of rotation evaluation form, and a downward shift in the PGY-1 scores and an upward shift in the PGY-3 scores. Conclusions: For faculty trained in both models of assessment, the Milestone-based model had greater discriminatory ability as evidenced by the larger separation in the scores for all the classes, in particular the PGY-1 class.

  20. Proposing melasma severity index: A new, more practical, office-based scoring system for assessing the severity of melasma

    Directory of Open Access Journals (Sweden)

    Imran Majid

    2016-01-01

    Full Text Available Background: Melasma Area and Severity Index (MASI, the scoring system in melasma, needs to be refined. Aims and Objectives: To propose a more practical scoring system, named as Melasma Severity Index (MSI, for assessing the disease severity and treatment response in melasma. Materials and Methods: Four dermatologists were trained to calculate MASI and also the proposed MSI scores. For MSI, the formula used was 0.4 (a × p 2 l + 0.4 (a × p 2 r + 0.2 (a × p 2 n where "a" stands for area, "p" for pigmentation, "l" for left face, "r" for right face, and "n" for nose. On a single day, 30 enrolled patients were randomly examined by each trained dermatologist and their MASI and MSI scores were calculated. Next, each rater re-examined every 6 th patient for repeat MASI and MSI scoring to assess intra- and inter-rater reliability of MASI and MSI scores. Validity was assessed by comparing the individual scores of each rater with objective data from mexameter and ImageJ software. Results: Inter-rater reliability, as assessed by intraclass correlation coefficient, was significantly higher for MSI (0.955 as compared to MASI (0.816. Correlation of scores with objective data by Spearman′s correlation revealed higher rho values for MSI than for MASI for all raters. Limitations: Sample population belonged to a single ethnic group. Conclusions: MSI is simpler and more practical scoring system for melasma.

  1. Performance scores in general practice: a comparison between the clinical versus medication-based approach to identify target populations.

    Directory of Open Access Journals (Sweden)

    Olivier Saint-Lary

    Full Text Available CONTEXT: From one country to another, the pay-for-performance mechanisms differ on one significant point: the identification of target populations, that is, populations which serve as a basis for calculating the indicators. The aim of this study was to compare clinical versus medication-based identification of populations of patients with diabetes and hypertension over the age of 50 (for men or 60 (for women, and any consequences this may have on the calculation of P4P indicators. METHODS: A comparative, retrospective, observational study was carried out with clinical and prescription data from a panel of general practitioners (GPs, the Observatory of General Medicine (OMG for the year 2007. Two indicators regarding the prescription for statins and aspirin in these populations were calculated. RESULTS: We analyzed data from 21.690 patients collected by 61 GPs via electronic medical files. Following the clinical-based approach, 2.278 patients were diabetic, 8,271 had hypertension and 1.539 had both against respectively 1.730, 8.511 and 1.304 following the medication-based approach (% agreement = 96%, kappa = 0.69. The main reasons for these differences were: forgetting to code the morbidities in the clinical approach, not taking into account the population of patients who were given life style and diet rules only or taking into account patients for whom morbidities other than hypertension could justify the use of antihypertensive drugs in the medication-based approach. The mean (confidence interval per doctor was 33.7% (31.5-35.9 for statin indicator and 38.4% (35.4-41.4 for aspirin indicator when the target populations were identified on the basis of clinical criteria whereas they were 37.9% (36.3-39.4 and 43.8% (41.4-46.3 on the basis of treatment criteria. CONCLUSION: The two approaches yield very "similar" scores but these scores cover different realities and offer food for thought on the possible usage of these indicators in the

  2. An external validation study reporting poor correlation between the claims-based index for rheumatoid arthritis severity and the disease activity score

    OpenAIRE

    Desai, Rishi J; Solomon, Daniel H; Weinblatt, Michael E.; Shadick, Nancy; Kim, Seoyoung C

    2015-01-01

    Introduction: We conducted an external validation study to examine the correlation of a previously published claims-based index for rheumatoid arthritis severity (CIRAS) with disease activity score in 28 joints calculated by using C-reactive protein (DAS28-CRP) and the multi-dimensional health assessment questionnaire (MD-HAQ) physical function score. Methods: Patients enrolled in the Brigham and Women’s Hospital Rheumatoid Arthritis Sequential Study (BRASS) and Medicare were identified and t...

  3. Development of a Korean Diet Score (KDS) and its application assessing adherence to Korean healthy diet based on the Korean Food Guide Wheels

    OpenAIRE

    Lee, Myoungsook; Chae, Soo Wan; Cha, Youn-Soo; Cho, Mi Sook; Oh, Hea Young; Kim, Mi Kyung

    2013-01-01

    The most critical point in the assessment of adherence to dietary guidelines is the development of a practical definition for adherence, such as a dietary pattern score. The purpose of this study was to develop the Korean Diet Score (KDS) based on the Korean Food Balance Wheel and to examine the association of KDS with various lifestyle characteristics and biochemical factors. The dietary data of 5,320 subjects from the 4th Korean National Health and Nutritional Examination Survey were used f...

  4. The Healthy Weights Initiative: a community-based obesity reduction program with positive impact on depressed mood scores

    Directory of Open Access Journals (Sweden)

    Lemstra ME

    2016-05-01

    Full Text Available Mark Edgar Lemstra,1 Marla Rochelle Rogers2 1Department of Psychiatry, 2Department of Physical Medicine and Rehabilitation, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada Objectives: The risk for many chronic diseases increases with obesity. In addition to these, the risk for depression also increases. Exercise interventions for weight loss among those who are not overweight or obese have shown a moderate effect on depression, but few studies have looked at those with obesity. The objectives of this study were to determine 1 the prevalence of depressed mood in obese participants as determined by the Beck Depression Inventory II at baseline and follow-up; 2 the change in depressed mood between those who completed the program and those who did not; and 3 the differences between those whose depressed mood was alleviated after the program and those who continued to have depressed mood. Methods: Depressed mood scores were calculated at baseline and follow-up for those who completed the program and for those who quit. Among those who completed the program, chi-squares were used to determine the differences between those who no longer had depressed mood and those who still had depressed mood at the end of the program, and regression analysis was used to determine the independent risk factors for still having depressed mood at program completion. Results: Depressed mood prevalence decreased from 45.7% to 11.7% (P<0.000 from baseline to follow-up among those who completed the program and increased from 44.8% to 55.6% (P<0.000 among those who quit. After logistic regression, a score of <40 in general health increased the risk of still having depressed mood upon program completion (odds ratio [OR] 3.39; 95% CI 1.18–9.72; P=0.023. Conclusion: Treating depressed mood among obese adults through a community-based, weight-loss program based on evidence may be an adjunct to medical treatment. More research is needed. Keywords: obesity

  5. qPCR based mRNA quality score show intact mRNA after heat stabilization

    Directory of Open Access Journals (Sweden)

    Oskar Karlsson

    2016-03-01

    Full Text Available Analysis of multiple analytes from biological samples can be challenging as different analytes require different preservation measures. Heat induced enzymatic inactivation is an efficient way to preserve proteins and their modifications in biological samples but RNA quality, as measured by RIN value, has been a concern in such samples. Here, we investigate the effect of heat stabilization compared with standard snap freezing on RNA quality using two RNA extraction protocols, QiaZol with and without urea pre-solubilization, and two RNA quality measurements: RIN value, as defined by the Agilent Bioanalyzer, and an alternative qPCR based method. DNA extraction from heat stabilized brain samples was also examined. The snap frozen samples had RIN values about 1 unit higher than heat stabilized samples for the direct QiaZol extraction but equal with stabilized samples using urea pre-solubilization. qPCR based RNA quality measurement showed no difference in quality between snap frozen and heat inactivated samples. The probable explanation for this discrepancy is that the RIN value is an indirect measure based on rRNA, while the qPCR score is based on actual measurement of mRNA quality. The DNA yield from heat stabilized brain tissue samples was significantly increased, compared to the snap frozen tissue, without any effects on purity or quality. Hence, heat stabilization of tissues opens up the possibility for a two step preservation protocol, where proteins and their modifications can be preserved in the first heat based step, while in a second step, using standard RNA preservation strategies, mRNA be preserved. This collection strategy will enable biobanking of samples where the ultimate analysis is not determined without loss of sample quality.

  6. qPCR based mRNA quality score show intact mRNA after heat stabilization.

    Science.gov (United States)

    Karlsson, Oskar; Segerström, Lova; Sjöback, Robert; Nylander, Ingrid; Borén, Mats

    2016-03-01

    Analysis of multiple analytes from biological samples can be challenging as different analytes require different preservation measures. Heat induced enzymatic inactivation is an efficient way to preserve proteins and their modifications in biological samples but RNA quality, as measured by RIN value, has been a concern in such samples. Here, we investigate the effect of heat stabilization compared with standard snap freezing on RNA quality using two RNA extraction protocols, QiaZol with and without urea pre-solubilization, and two RNA quality measurements: RIN value, as defined by the Agilent Bioanalyzer, and an alternative qPCR based method. DNA extraction from heat stabilized brain samples was also examined. The snap frozen samples had RIN values about 1 unit higher than heat stabilized samples for the direct QiaZol extraction but equal with stabilized samples using urea pre-solubilization. qPCR based RNA quality measurement showed no difference in quality between snap frozen and heat inactivated samples. The probable explanation for this discrepancy is that the RIN value is an indirect measure based on rRNA, while the qPCR score is based on actual measurement of mRNA quality. The DNA yield from heat stabilized brain tissue samples was significantly increased, compared to the snap frozen tissue, without any effects on purity or quality. Hence, heat stabilization of tissues opens up the possibility for a two step preservation protocol, where proteins and their modifications can be preserved in the first heat based step, while in a second step, using standard RNA preservation strategies, mRNA be preserved. This collection strategy will enable biobanking of samples where the ultimate analysis is not determined without loss of sample quality. PMID:27077049

  7. CORRELATION OF PEMPHIGUS VULGARIS ANTIBODY TITERS BY INDIRECT IMMUNOFLUORESCENCE WITH ACTIVITY OF DISEASE BASED ON PEMPHIGUS AREA AND ACTIVITY SCORE (PAAS

    Directory of Open Access Journals (Sweden)

    H. Mortazavi

    2008-06-01

    Full Text Available Indirect immunofluorescence (IIF has been used to identify and measure autoantibody levels in pemphigus vulgaris but data about relationship between clinical severity of disease and antibody titers by IIF have been conflicting. We conducted this cross-sectional study to correlate the severity of oral and/or cutaneous involvement in patients with pemphigus vulgaris based on Pemphigus Area and Activity Score with IIF titers. Sixty-one new pemphigus vulgaris patients were included in this study. Human prepuce was used as substrate for IIF and assessment of disease severity was based on Pemphigus Area and Activity Score. The mean±SD age was 44.04±30.46 years, with a range of 18 to 79 years. IIF was positive in 56 (91.8% patients. There was a significant relationship between total disease score and IIF titers ((P<0.001. Also a significant relationship was found between skin score (P=0.04 and mucosal score (P=0.04 with IIF titers. Our results show that there is a significant relationship between disease activity based on Pemphigus Area and Activity Score and antibody titers by IIF. Further studies are recommended to determine the usefulness of this technique for monitoring disease.

  8. Estimation of cardiac event risk by gated myocardial perfusion imaging and quantitative scoring methods based on a multi-center J-ACCESS database

    International Nuclear Information System (INIS)

    Myocardial perfusion imaging (MPI) has been used to estimate cardiac event risk. The aim of the present study is to achieve stable risk estimation based on perfusion scoring and a multi-center prognostic database. Multivariate logistic regression analysis was performed to estimate cardiac event risk based on a Japanese Assessment of Cardiac Event and Survival (J-ACCESS) study. A stress-MPI was performed in 45 patients with coronary artery disease (CAD) and in 25 non-CAD patients. Perfusion defect scoring of summed stress score (SSS) was performed by 5 methods: visual scoring; automatic scoring of 3 short-axis and 1 vertical long-axis slices; visual modification of Method 2; automatic polar map scoring based on a Japanese multi-center database; and visual modification of Method 4. Agreement of SSS between 2 observers was good (r=0.87-0.97). Agreement of estimated cardiac event risk between observers and among 5 methods was very good (r=0.99-1.00). Regarding diagnostic accuracy for CAD, Method 5 showed optimal diagnostic yields (sensitivity 84%, accuracy 77%). Estimation of cardiac event risk in conjunction with polar map segmentation and common normal databases resulted in stable risk values, and might be used for risk stratification in patients suspected of having CAD. (author)

  9. Predictive value of semi-quantitative MRI-based scoring systems for future knee replacement: data from the osteoarthritis initiative

    International Nuclear Information System (INIS)

    To evaluate, in a confirmatory fashion, whether baseline and change from baseline to 24-month follow-up in cartilage damage, bone marrow lesions and meniscal damage are predictors of knee replacement (KR) in subjects with a high risk of osteoarthritis (OA), independent of the level of physical activity, symptom severity and radiographic abnormalities. Data from the Osteoarthritis Initiative's (OAI) baseline and 24-month follow-up knee MRIs of 115 patients (age range: 45-78 years; 48 % female; BMI: 20.9-48.7) were analyzed. Cartilage, bone marrow and menisci were semi-quantitatively scored according to the Whole-Organ Magnetic Resonance Imaging Score (WORMS) and Boston-Leeds Osteoarthritis Knee Score (BLOKS) systems in all compartments. Baseline and 24-month interval changes in structural tissue damage assessed by BLOKS and WORMS were used as predictors of KR independent of clinical and radiographic parameters using Cox hazard analysis. Adjustments were performed for age, gender, BMI and physical activity (Physical Activity Scale for the Elderly: PASE), Western Ontario and McMaster Questionnaire (WOMAC) total score and radiographic Kellgren-Lawrence (KL) score. BLOKS and WORMS baseline cartilage scores were predictors of KR independent of the PASE, WOMAC and KL score. One score increase in the average baseline BLOKS full-thickness cartilage defect score was associated with a [hazard ratio (95 % CI)] 13.55 (3.61-50.89) times greater risk of KR independent of the PASE, WOMAC and KL score. Net reclassification improvements (NRIs) of the additional evaluation of 24-month follow-up MRI scores and assessment of changes were not significant for prediction of KR (NRI range: - 7.23 - 24.8 %). The BLOKS cartilage score for full-thickness cartilage defects had the highest hazard for KR. Follow-up MRI changes in structural tissue damage, detected by BLOKS and WORMS cartilage, bone marrow or meniscus scores (up to 24 months) had no significant predictive value in addition

  10. Predictive value of semi-quantitative MRI-based scoring systems for future knee replacement: data from the osteoarthritis initiative

    Energy Technology Data Exchange (ETDEWEB)

    Hafezi-Nejad, Nima; Eng, John; Demehri, Shadpour [Johns Hopkins University School of Medicine, Musculoskeletal Radiology, Russell H. Morgan Department of Radiology and Radiological Science, Baltimore, MD (United States); Zikria, Bashir [Johns Hopkins University, Department of Orthopedic Surgery, Baltimore, MD (United States); Carrino, John A. [Hospital for Special Surgery, Department of Radiology and Imaging, New York, NY (United States)

    2015-11-15

    To evaluate, in a confirmatory fashion, whether baseline and change from baseline to 24-month follow-up in cartilage damage, bone marrow lesions and meniscal damage are predictors of knee replacement (KR) in subjects with a high risk of osteoarthritis (OA), independent of the level of physical activity, symptom severity and radiographic abnormalities. Data from the Osteoarthritis Initiative's (OAI) baseline and 24-month follow-up knee MRIs of 115 patients (age range: 45-78 years; 48 % female; BMI: 20.9-48.7) were analyzed. Cartilage, bone marrow and menisci were semi-quantitatively scored according to the Whole-Organ Magnetic Resonance Imaging Score (WORMS) and Boston-Leeds Osteoarthritis Knee Score (BLOKS) systems in all compartments. Baseline and 24-month interval changes in structural tissue damage assessed by BLOKS and WORMS were used as predictors of KR independent of clinical and radiographic parameters using Cox hazard analysis. Adjustments were performed for age, gender, BMI and physical activity (Physical Activity Scale for the Elderly: PASE), Western Ontario and McMaster Questionnaire (WOMAC) total score and radiographic Kellgren-Lawrence (KL) score. BLOKS and WORMS baseline cartilage scores were predictors of KR independent of the PASE, WOMAC and KL score. One score increase in the average baseline BLOKS full-thickness cartilage defect score was associated with a [hazard ratio (95 % CI)] 13.55 (3.61-50.89) times greater risk of KR independent of the PASE, WOMAC and KL score. Net reclassification improvements (NRIs) of the additional evaluation of 24-month follow-up MRI scores and assessment of changes were not significant for prediction of KR (NRI range: - 7.23 - 24.8 %). The BLOKS cartilage score for full-thickness cartilage defects had the highest hazard for KR. Follow-up MRI changes in structural tissue damage, detected by BLOKS and WORMS cartilage, bone marrow or meniscus scores (up to 24 months) had no significant predictive value in addition

  11. School-based assessments in high-stakes examinations in Bhutan: a question of trust? Exploring inconsistencies between external exam scores, school-based assessments, detailed teacher ratings, and student self-ratings

    NARCIS (Netherlands)

    Luyten, Hans; Dolkar, Dechen

    2010-01-01

    This study explores the validity of school-based assessments when they serve to supplement scores on central tests in high-stakes examinations. The school-based continuous assessment (CA) marks are compared to the marks scored on the central written Bhutan Certificate of Secondary Education (BCSE) e

  12. Proposing Melasma Severity Index: A New, More Practical, Office-based Scoring System for Assessing the Severity of Melasma

    OpenAIRE

    Imran Majid; Inaamul Haq; Saher Imran; Abid Keen; Khalid Aziz; Tasleem Arif

    2016-01-01

    Background: Melasma Area and Severity Index (MASI), the scoring system in melasma, needs to be refined. Aims and Objectives: To propose a more practical scoring system, named as Melasma Severity Index (MSI), for assessing the disease severity and treatment response in melasma. Materials and Methods: Four dermatologists were trained to calculate MASI and also the proposed MSI scores. For MSI, the formula used was 0.4 (a × p 2 ) l + 0.4 (a × p 2 ) r + 0.2 (a × p 2 ) n where "a" stands for area,...

  13. COLLECTION SCORING

    Directory of Open Access Journals (Sweden)

    Skiba S. A.

    2013-11-01

    Full Text Available One of the most popular methodologies of credit indebtedness management is used by banks, financial institutions and the collection agency has been considered in this article based on the experiment. This experiment demonstrates the methods of estimations of the client’s solvency and the way to impact to debitors. The article is accompanied with explanations and conclusion

  14. The clinical performance of an office-based risk scoring system for fatal cardiovascular diseases in North-East of Iran.

    Directory of Open Access Journals (Sweden)

    Sadaf G Sepanlou

    Full Text Available Cardiovascular diseases (CVD are becoming major causes of death in developing countries. Risk scoring systems for CVD are needed to prioritize allocation of limited resources. Most of these risk score algorithms have been based on a long array of risk factors including blood markers of lipids. However, risk scoring systems that solely use office-based data, not including laboratory markers, may be advantageous. In the current analysis, we validated the office-based Framingham risk scoring system in Iran.The study used data from the Golestan Cohort in North-East of Iran. The following risk factors were used in the development of the risk scoring method: sex, age, body mass index, systolic blood pressure, hypertension treatment, current smoking, and diabetes. Cardiovascular risk functions for prediction of 10-year risk of fatal CVDs were developed.A total of 46,674 participants free of CVD at baseline were included. Predictive value of estimated risks was examined. The resulting Area Under the ROC Curve (AUC was 0.774 (95% CI: 0.762-0.787 in all participants, 0.772 (95% CI: 0.753-0.791 in women, and 0.763 (95% CI: 0.747-0.779 in men. AUC was higher in urban areas (0.790, 95% CI: 0.766-0.815. The predicted and observed risks of fatal CVD were similar in women. However, in men, predicted probabilities were higher than observed.The AUC in the current study is comparable to results of previous studies while lipid profile was replaced by body mass index to develop an office-based scoring system. This scoring algorithm is capable of discriminating individuals at high risk versus low risk of fatal CVD.

  15. Performance Assessment of the Food Industry of Tehran Stock Exchange Based on Balanced Score Card (BSC Technique

    Directory of Open Access Journals (Sweden)

    Morteza Asadi

    2013-04-01

    Full Text Available Major objective of the present paper was to study the role of balanced score card regarding performance assessment of companies listed in food and beverage industry in the stock exchange. This survey is descriptive and is regarded as a quasi-experimental research plan (Ex-Post design. The statistical population included 200 managers and research sample consisted of 99 persons based on Cochran formula. Questionnaire was used for data collection. Frequency tables and appropriate diagrams were applied to describe data and inferential statistics methods such as student's t-test were used to confirm or reject hypotheses. Variance analysis and t-test for two independent samples were used to study the impact of personal characteristics on responding to the hypotheses. Ranking of improvement degree of indexes for realization of purposes and determining rank of each factor was studied using Friedman test. Results of testing hypotheses reveal it is necessary for organizations to emphasize internal processes more given that planning and implementing efficient and suitable processes in the organization is led to offering appropriate services. About growth and learning scope it is notable that since employees are major capitals of the organization, special attention must be paid to this sector in order to satisfy employees and provide long-term benefits of the organization.

  16. Thoracolumbar Tuberculosis: Implications for Appropriate Management based on Disease Location and Proposal of a Novel Scoring System

    Directory of Open Access Journals (Sweden)

    Shahryar Noordin

    2011-01-01

    Full Text Available Objective: To identify factors indicating disease severity in patients with thoracolumbar tuberculosis requiring surgical intervention.Design: Medical charts of patients who underwent surgery for thoracic and lumbar spinal tuberculosis from 1990-2005 were reviewed. Patients with different levels of disease were compared in terms of neurological deficits, duration of symptoms, previous antituberculous therapy, nutritional status and associated co-morbids.Results: Ninety-three patients aged 7-77 years (mean age 40 years were included. Thoracic spine was involved in 80% of operated patients, and lumbar spine in 20%. Severe neurological impairment (Frankel A to C was present in 68% of patients with thoracic disease, as compared to 5% with lumbar disease (p<0.05. Postoperatively, complete neurological recovery occurred in 65% with thoracic versus 100% with lumbar disease (p<0.05. Based on the disease location and pertinent elements in clinical history, physical signs, radiographic and biochemical features, a scoring system was developed.Conclusion: In endemic areas with limited resources, strategies for cost-effective care are needed. By objectively outlining the treatment approach, the judicious use of surgery offers hope for enormous cost savings in countries endemic for tuberculosis, averting complications from disease progression

  17. The Impact of Individual Ability, Favorable Team Member Scores, and Student Perception of Course Importance on Student Preference of Team-Based Learning and Grading Methods

    Science.gov (United States)

    Su, Allan Yen-Lun

    2007-01-01

    This study explores the impact of individual ability and favorable team member scores on student preference of team-based learning and grading methods, and examines the moderating effects of student perception of course importance on student preference of team-based learning and grading methods. The author also investigates the relationship…

  18. Comparison of Alzheimer's disease with vascular dementia and non-dementia using specific voxel-based Z score maps

    International Nuclear Information System (INIS)

    We investigated the ability to discriminate between Alzheimer's disease (AD) and vascular dementia (VaD), and between AD and non-dementia using the program ''easy Z score imaging system'' (eZIS) developed by Matsuda et al., for the diagnosis of very early AD. Of 201 patients, we investigated 12 patients with AD, 10 with VaD, and 9 with non-dementia, who underwent brain perfusion single-photon emission computed tomography by technetium-99m ethyl cysteinate dimer (99mTc-ECD) between February 2005 and September 2006. The sensitivity and specificity of the indicators of specific volume of interest (VOI) analysis, namely, severity, extent, and ratio were evaluated for the distinction of AD from VaD and non-dementia. There was a significant difference in all the criteria for severity, extent, and ratio between AD and non-dementia cases and in the ratio between AD and VaD. Between AD and non-dementia, the sensitivity and specificity of severity were 100% and 45%, respectively, using the cutoff value of 1.19. When using the cutoff value of 14.2 for extent, the sensitivity and specificity were both 100%. Using the cutoff value of 2.22 for ratio, the sensitivity of 42% and specificity of 100% were demonstrated. When comparing AD with VaD, using the cutoff value of 2.22 for ratio, the sensitivity and specificity were 42% and 100%, respectively. Using the cutoff value of 1.5 for ratio, the sensitivity and specificity between AD and VaD were 92% and 80%, respectively, thereby showing the best results. The specific VOI analysis program of AD using specific voxel-based Z score maps is not influenced by interobserver differences among radiologists and is useful to discriminate AD from VaD and non-dementia. However, the setting of the cutoff value at each institution and comparison with original and eZIS images are suggested to distinguish better AD from VaD. (author)

  19. Nursing activities score

    NARCIS (Netherlands)

    Miranda, DR; Nap, R; de Rijk, A; Schaufeli, W; Lapichino, G

    2003-01-01

    Objectives. The instruments used for measuring nursing workload in the intensive care unit (e.g., Therapeutic Intervention Scoring System-28) are based on therapeutic interventions related to severity of illness. Many nursing activities are not necessarily related to severity of illness, and cost-ef

  20. Development of an automated updated selvester QRS scoring system using SWT-based QRS fractionation detection and classification

    OpenAIRE

    Bono, Valentina; Mazomenos, Evangelos B.; Chen, Taihai; Rosengarten, James; Acharyya, Amit; Maharatna, Koushik; Morgan, John M.; Curzen, Nick

    2014-01-01

    The Selvester score is an effective means for estimating the extent of myocardial scar in a patient from lowcost ECG recordings. Automation of such a system is deemed to help implementing low-cost high-volume screening mechanisms of scar in the primary care. This article describes, for the first time to the best of our knowledge, an automated implementation of the updated Selvester scoring system for that purpose, where fractionated QRS morphologies and patterns are identified and classified ...

  1. DrugScorePPI webserver: fast and accurate in silico alanine scanning for scoring protein–protein interactions

    OpenAIRE

    Krüger, Dennis M; Gohlke, Holger

    2010-01-01

    Protein–protein complexes play key roles in all cellular signal transduction processes. We have developed a fast and accurate computational approach to predict changes in the binding free energy upon alanine mutations in protein–protein interfaces. The approach is based on a knowledge-based scoring function, DrugScorePPI, for which pair potentials were derived from 851 complex structures and adapted against 309 experimental alanine scanning results. Based on this approach, we developed the Dr...

  2. Reliability and Determinants of Self-Evaluation of Breathing Questionnaire (SEBQ) Score: A Symptoms-Based Measure of Dysfunctional Breathing.

    Science.gov (United States)

    Mitchell, A J; Bacon, C J; Moran, R W

    2016-03-01

    Dysfunctional breathing is characterised by an abnormal breathing pattern leading to respiratory symptoms. The 25-item Self Evaluation of Breathing Questionnaire (SEBQ) has been developed to measure breathing-related symptoms and their severity but lacks thorough evaluation. To determine reproducibility, internal consistency and predictors of SEBQ score, 180 participants completed an online SEBQ with additional demographic and lifestyle questions. Two weeks later, 155 of those repeated SEBQ. Test-retest correlation of the SEBQ was high [intraclass correlation coefficient (3, 1) = 0.89; 95 % CI 0.85-0.92]. There was no difference in SEBQ score between test and retest (15.1 (11.6) [mean (SD)] versus 14.7 (12.4); P = 0.4) and the score showed a typical error (standard error of measurement) of 4.0. Internal consistency was high (Cronbach's α = 0.93), and a single factor structure for items was shown. Smoking status, reported respiratory disease, recent respiratory illness and female gender were positively-associated predictors of SEBQ score, and together explained 25.6 % of score variance (P ≤ 0.001). The SEBQ has high test-retest reproducibility and its score may be predicted by current smoking, chronic respiratory disease, recent respiratory illness and female gender, thus may be a useful clinical screening tool for dysfunctional breathing. PMID:26400252

  3. An 8-gene qRT-PCR-based gene expression score that has prognostic value in early breast cancer

    Directory of Open Access Journals (Sweden)

    Cejas Paloma

    2010-06-01

    Full Text Available Abstract Background Gene expression profiling may improve prognostic accuracy in patients with early breast cancer. Our objective was to demonstrate that it is possible to develop a simple molecular signature to predict distant relapse. Methods We included 153 patients with stage I-II hormonal receptor-positive breast cancer. RNA was isolated from formalin-fixed paraffin-embedded samples and qRT-PCR amplification of 83 genes was performed with gene expression assays. The genes we analyzed were those included in the 70-Gene Signature, the Recurrence Score and the Two-Gene Index. The association among gene expression, clinical variables and distant metastasis-free survival was analyzed using Cox regression models. Results An 8-gene prognostic score was defined. Distant metastasis-free survival at 5 years was 97% for patients defined as low-risk by the prognostic score versus 60% for patients defined as high-risk. The 8-gene score remained a significant factor in multivariate analysis and its performance was similar to that of two validated gene profiles: the 70-Gene Signature and the Recurrence Score. The validity of the signature was verified in independent cohorts obtained from the GEO database. Conclusions This study identifies a simple gene expression score that complements histopathological prognostic factors in breast cancer, and can be determined in paraffin-embedded samples.

  4. An 8-gene qRT-PCR-based gene expression score that has prognostic value in early breast cancer

    International Nuclear Information System (INIS)

    Gene expression profiling may improve prognostic accuracy in patients with early breast cancer. Our objective was to demonstrate that it is possible to develop a simple molecular signature to predict distant relapse. We included 153 patients with stage I-II hormonal receptor-positive breast cancer. RNA was isolated from formalin-fixed paraffin-embedded samples and qRT-PCR amplification of 83 genes was performed with gene expression assays. The genes we analyzed were those included in the 70-Gene Signature, the Recurrence Score and the Two-Gene Index. The association among gene expression, clinical variables and distant metastasis-free survival was analyzed using Cox regression models. An 8-gene prognostic score was defined. Distant metastasis-free survival at 5 years was 97% for patients defined as low-risk by the prognostic score versus 60% for patients defined as high-risk. The 8-gene score remained a significant factor in multivariate analysis and its performance was similar to that of two validated gene profiles: the 70-Gene Signature and the Recurrence Score. The validity of the signature was verified in independent cohorts obtained from the GEO database. This study identifies a simple gene expression score that complements histopathological prognostic factors in breast cancer, and can be determined in paraffin-embedded samples

  5. Present status of severe head injured patients with an admission glasgow coma scale score of 3 based on the Japan neurotrauma data bank

    International Nuclear Information System (INIS)

    Severe head injured patients presenting with Glasgow Coma Scale (GCS) score of 3 have been hesitated to treat aggressively. We analyzed present status of patients with GCS score of 3 from the Project 2004 in the Japan Neurotrauma Data Bank. Among 1,101 cases registered, 805 cases with GCS score of 8 or less on admission. Of those, 215 cases with GCS score of 3 were classified the survival group (51 cases) and the dead group (164 cases) and compared each group. These results showed that the characteristics associated with favorable outcome including absence of cardiopulmonary arrest, no abnormality of pupil findings, stable condition of respiration and circulation, serum glucose level (less than 184 mg/dl), absence of initial CT findings including skull base fracture, pneumocephalus and subarachnoid hemorrhage, no serious extracranial injures including Injury Severity Scale score of less than 25, critic al care including intracranial pressure monitoring and temperature management. We suggest that it is important to treat brain and systemic problems aggressively in severe head injured patients with GCS score of 3. (author)

  6. Derivation and Cross-Validation of Cutoff Scores for Patients With Schizophrenia Spectrum Disorders on WAIS-IV Digit Span-Based Performance Validity Measures.

    Science.gov (United States)

    Glassmire, David M; Toofanian Ross, Parnian; Kinney, Dominique I; Nitch, Stephen R

    2016-06-01

    Two studies were conducted to identify and cross-validate cutoff scores on the Wechsler Adult Intelligence Scale-Fourth Edition Digit Span-based embedded performance validity (PV) measures for individuals with schizophrenia spectrum disorders. In Study 1, normative scores were identified on Digit Span-embedded PV measures among a sample of patients (n = 84) with schizophrenia spectrum diagnoses who had no known incentive to perform poorly and who put forth valid effort on external PV tests. Previously identified cutoff scores resulted in unacceptable false positive rates and lower cutoff scores were adopted to maintain specificity levels ≥90%. In Study 2, the revised cutoff scores were cross-validated within a sample of schizophrenia spectrum patients (n = 96) committed as incompetent to stand trial. Performance on Digit Span PV measures was significantly related to Full Scale IQ in both studies, indicating the need to consider the intellectual functioning of examinees with psychotic spectrum disorders when interpreting scores on Digit Span PV measures. PMID:25997434

  7. A pilot study on the application of a symptom-based score for the diagnosis of cow’s milk protein allergy

    OpenAIRE

    Vandenplas, Yvan; ,; Steenhout, Philippe; Grathwohl, Dominik

    2014-01-01

    Objective: A challenge is the recommended test to diagnose cow’s milk protein allergy. However, many parents and physicians prefer to not challenge because the procedure may cause (severe) symptoms. In clinical routine, diagnostic testing is only available for IgE-mediated allergy. The aim of this study was to test the diagnostic accuracy of a symptom-based score to select infants at risk of having cow’s milk protein allergy. Methods: A symptom-based score was developed and consensus was reac...

  8. Validity and Agreement between the 28-Joint Disease Activity Score Based on C-Reactive Protein and Erythrocyte Sedimentation Rate in Patients with Rheumatoid Arthritis

    DEFF Research Database (Denmark)

    Nielung, Louise; Christensen, Robin; Danneskiold-Samsøe, Bente;

    2015-01-01

    Objective. To validate the agreement between the 28-joint disease activity score based on erythrocyte sedimentation rate (DAS28-ESR) and the 28-joint disease activity score based on C-reactive protein (DAS28-CRP) in a group of Danish patients with rheumatoid arthritis (RA). Methods. Data from 109...... Danish RA patients initiating biologic treatment were analysed at baseline and following one year of treatment. Participants were retrospectively enrolled from a previous cohort study and were considered eligible for this project if CRP and ESR were measured at baseline and at the follow-up visit. To...

  9. Micromotor-based energy generation.

    Science.gov (United States)

    Singh, Virendra V; Soto, Fernando; Kaufmann, Kevin; Wang, Joseph

    2015-06-01

    A micromotor-based strategy for energy generation, utilizing the conversion of liquid-phase hydrogen to usable hydrogen gas (H2), is described. The new motion-based H2-generation concept relies on the movement of Pt-black/Ti Janus microparticle motors in a solution of sodium borohydride (NaBH4) fuel. This is the first report of using NaBH4 for powering micromotors. The autonomous motion of these catalytic micromotors, as well as their bubble generation, leads to enhanced mixing and transport of NaBH4 towards the Pt-black catalytic surface (compared to static microparticles or films), and hence to a substantially faster rate of H2 production. The practical utility of these micromotors is illustrated by powering a hydrogen-oxygen fuel cell car by an on-board motion-based hydrogen and oxygen generation. The new micromotor approach paves the way for the development of efficient on-site energy generation for powering external devices or meeting growing demands on the energy grid. PMID:25906739

  10. Confidence scores for prediction models

    DEFF Research Database (Denmark)

    Gerds, Thomas Alexander; van de Wiel, MA

    2011-01-01

    distinguish rival prediction models with similar prediction performances. Furthermore, on the subject level a confidence score may provide useful supplementary information for new patients who want to base a medical decision on predicted risk. The ideas are illustrated and discussed using data from cancer...... modelling strategy is applied to different training sets. For each modelling strategy we estimate a confidence score based on the same repeated bootstraps. A new decomposition of the expected Brier score is obtained, as well as the estimates of population average confidence scores. The latter can be used to...

  11. A comparison of the prognostic value of preoperative inflammation-based scores and TNM stage in patients with gastric cancer

    Directory of Open Access Journals (Sweden)

    Pan QX

    2015-06-01

    Full Text Available Qun-Xiong Pan,* Zi-Jian Su,* Jian-Hua Zhang, Chong-Ren Wang, Shao-Ying KeDepartment of Oncosurgery, Quanzhou First Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, People’s Republic of China*These authors contributed equally to this workBackground: People’s Republic of China is one of the countries with the highest incidence of gastric cancer, accounting for 45% of all new gastric cancer cases in the world. Therefore, strong prognostic markers are critical for the diagnosis and survival of Chinese patients suffering from gastric cancer. Recent studies have begun to unravel the mechanisms linking the host inflammatory response to tumor growth, invasion and metastasis in gastric cancers. Based on this relationship between inflammation and cancer progression, several inflammation-based scores have been demonstrated to have prognostic value in many types of malignant solid tumors.Objective: To compare the prognostic value of inflammation-based prognostic scores and tumor node metastasis (TNM stage in patients undergoing gastric cancer resection.Methods: The inflammation-based prognostic scores were calculated for 207 patients with gastric cancer who underwent surgery. Glasgow prognostic score (GPS, neutrophil lymphocyte ratio (NLR, platelet lymphocyte ratio (PLR, prognostic nutritional index (PNI, and prognostic index (PI were analyzed. Linear trend chi-square test, likelihood ratio chi-square test, and receiver operating characteristic were performed to compare the prognostic value of the selected scores and TNM stage.Results: In univariate analysis, preoperative serum C-reactive protein (P<0.001, serum albumin (P<0.001, GPS (P<0.001, PLR (P=0.002, NLR (P<0.001, PI (P<0.001, PNI (P<0.001, and TNM stage (P<0.001 were significantly associated with both overall survival and disease-free survival of patients with gastric cancer. In multivariate analysis, GPS (P=0.024, NLR (P=0.012, PI (P=0.001, TNM stage (P<0.001, and degree of

  12. N-terminal pro b-type natriuretic peptide (NT-pro-BNP) -based score can predict in-hospital mortality in patients with heart failure.

    Science.gov (United States)

    Huang, Ya-Ting; Tseng, Yuan-Teng; Chu, Tung-Wei; Chen, John; Lai, Min-Yu; Tang, Woung-Ru; Shiao, Chih-Chung

    2016-01-01

    Serum N-terminal pro b-type natriuretic peptide (NT-pro-BNP) testing is recommended in the patients with heart failure (HF). We hypothesized that NT-pro-BNP, in combination with other clinical factors in terms of a novel NT-pro BNP-based score, may provide even better predictive power for in-hospital mortality among patients with HF. A retrospective study enrolled adult patients with hospitalization-requiring HF who fulfilled the predefined criteria during the period from January 2011 to December 2013. We proposed a novel scoring system consisting of several independent predictors including NT-pro-BNP for predicting in-hospital mortality, and then compared the prognosis-predictive power of the novel NT-pro BNP-based score with other prognosis-predictive scores. A total of 269 patients were enrolled in the current study. Factors such as "serum NT-pro-BNP level above 8100 mg/dl," "age above 79 years," "without taking angiotensin converting enzyme inhibitors/angiotensin receptor blocker," "without taking beta-blocker," "without taking loop diuretics," "with mechanical ventilator support," "with non-invasive ventilator support," "with vasopressors use," and "experience of cardio-pulmonary resuscitation" were found as independent predictors. A novel NT-pro BNP-based score composed of these risk factors was proposed with excellent predictability for in-hospital mortality. The proposed novel NT-pro BNP-based score was extremely effective in predicting in-hospital mortality in HF patients. PMID:27411951

  13. Performance of the Finnish Diabetes Risk Score and a Simplified Finnish Diabetes Risk Score in a Community-Based, Cross-Sectional Programme for Screening of Undiagnosed Type 2 Diabetes Mellitus and Dysglycaemia in Madrid, Spain: The SPREDIA-2 Study

    Science.gov (United States)

    Burgos-Lunar, C.; Lahoz, C.; Mostaza, J. M.; Abánades-Herranz, J. C.; Laguna-Cuesta, F.; Estirado-de Cabo, E.; García-Iglesias, F.; González-Alegre, T.; Fernández-Puntero, B.; Montesano-Sánchez, L.; Vicent-López, D.; Cornejo-del Río, V.; Fernández-García, P. J.; Sánchez-Arroyo, V.; Sabín-Rodríguez, C.; López-López, S.; Patrón-Barandio, P.; Gómez-Campelo, P.

    2016-01-01

    Aim To evaluate the performance of the Finnish Diabetes Risk Score (FINDRISC) and a simplified FINDRISC score (MADRISC) in screening for undiagnosed type 2 diabetes mellitus (UT2DM) and dysglycaemia. Methods A population-based, cross-sectional, descriptive study was carried out with participants with UT2DM, ranged between 45–74 years and lived in two districts in the north of metropolitan Madrid (Spain). The FINDRISC and MADRISC scores were evaluated using the area under the receiver operating characteristic curve method (ROC-AUC). Four different gold standards were used for UT2DM and any dysglycaemia, as follows: fasting plasma glucose (FPG), oral glucose tolerance test (OGTT), HbA1c, and OGTT or HbA1c. Dysglycaemia and UT2DM were defined according to American Diabetes Association criteria. Results The study population comprised 1,426 participants (832 females and 594 males) with a mean age of 62 years (SD = 6.1). When HbA1c or OGTT criteria were used, the prevalence of UT2DM was 7.4% (10.4% in men and 5.2% in women; p<0.01) and the FINDRISC ROC-AUC for UT2DM was 0.72 (95% CI, 0.69–0.74). The optimal cut-off point was ≥13 (sensitivity = 63.8%, specificity = 65.1%). The ROC-AUC of MADRISC was 0.76 (95% CI, 0.72–0.81) with ≥13 as the optimal cut-off point (sensitivity = 84.8%, specificity = 54.6%). FINDRISC score ≥12 for detecting any dysglycaemia offered the best cut-off point when HbA1c alone or OGTT and HbA1c were the criteria used. Conclusions FINDRISC proved to be a useful instrument in screening for dysglycaemia and UT2DM. In the screening of UT2DM, the simplified MADRISC performed as well as FINDRISC. PMID:27441722

  14. A competing risk approach for the European Heart SCORE model based on cause-specific and all-cause mortality

    DEFF Research Database (Denmark)

    Støvring, Henrik; Harmsen, Charlotte G; Wisløff, Torbjørn;

    2013-01-01

    Background: The European Heart SCORE model constitutes the basis for national guidelines for primary prevention and treatment of cardiovascular disease (CVD) in several European countries. The model estimates individuals' 10-year CVD mortality risks from age, sex, smoking status, systolic blood...... pressure, and total cholesterol level. The SCORE model, however, is not mathematically consistent and does not estimate all-cause mortality. Our aim is to modify the SCORE model to allow consistent estimation of both CVD-specific and all-cause mortality. Methods: Using a competing risk approach, we first...... re-estimated the cause-specific risk of dying from cardiovascular disease, and secondly we incorporated non-CVD mortality. Finally, non-CVD mortality was allowed to also depend on smoking status, and not only age and sex. From the models, we estimated CVD-specific and all-cause 10-year mortality risk...

  15. Credit Scores and College Investment

    OpenAIRE

    Nicole Simpson; Felicia Ionescu

    2010-01-01

    The private market of student loans has become an important source of college financing in the U.S. Unlike government student loans, the terms on private student loans (i.e., credit limits and interest rates) are based on credit scores We quantify the effects of credit scores on college investment in a heterogeneous life-cycle economy that exhibits a government and private market for student loans. We find that students with higher credit scores invest in more college education. Furthermore, ...

  16. Computed Tomography Coronary Artery Calcium Scoring Review of Evidence Base and Cost-effectiveness in Cardiovascular Risk Prediction

    NARCIS (Netherlands)

    Vliegenthart, Rozemarijn; Morris, Pamela B.

    2012-01-01

    Cardiovascular risk factor-scoring algorithms may fall short in identifying asymptomatic individuals who will subsequently suffer a coronary event. It is generally thought that evaluation of the extent of the atherosclerotic plaque and total plaque burden can improve cardiovascular risk stratificati

  17. Structure Coefficients versus Scoring Coefficients as Bases for Interpreting Emergent Variables in Multiple Regression and Related Techniques.

    Science.gov (United States)

    Harris, Richard J.

    Interpretation of emergent variables on the basis of structure coefficients (zero order correlations between original and emergent variables) is potentially very misleading and should be avoided in favor of interpretation on the basis of scoring coefficients. This is most apparent in multiple regression analysis and its special case, two-group…

  18. Magnetic resonance and computed tomography-based scoring system for the differential diagnosis of vertebral fractures caused by osteoporosis and malignant tumors

    International Nuclear Information System (INIS)

    Previous reports have described magnetic resonance imaging (MRI) findings alleged to be specific for vertebral fractures caused by malignant lesions. Using such findings for differential diagnosis is often difficult, especially during the early phase of the fracture. With the relative inaccuracy of any single imaging finding, a validated scoring system based on a combination of imaging findings might lead to enhanced diagnostic accuracy. The purpose of this study was to establish a diagnostic scoring system for discriminating osteoporotic vertebral fractures from those caused by malignant tumors on the basis of MRI and computed tomography (CT) findings. Ten MRI and CT scan findings of 57 osteoporotic vertebral fractures and 43 neoplastic fractures were retrospectively evaluated for their ability to discriminate between malignant and benign vertebral fractures. The following four MRI and two CT findings were selected as the basis for the scoring system: pedicle or other posterior element involvement; extension into the paravertebral region; preservation of normal bone marrow signal; a continuous black line representing the posterior vertebral body margin on T2-weighted MRI images; osteolytic destruction; and distinct fracture lines on CT. By combining the findings common to MRI and CT scans of vertebral fractures, a simple scoring system was devised. This scoring system was found to enhance the accuracy of imaging diagnosis of fractures caused by benign or malignant spinal lesions. (author)

  19. On-farm estimation of energy balance in dairy cows using only frequent body weight measurements and body condition score

    DEFF Research Database (Denmark)

    Thorup, Vivi Mørkøre; Edwards, David; Friggens, N C

    2012-01-01

    Precise energy balance estimates for individual cows are of great importance to health, reproduction and feed management. Energy balance is usually calculated as energy input minus output (EBalinout), requiring measurements of feed intake and energy output sources (milk, maintenance, activity......, growth and pregnancy). Except milk yield, direct measurements of these are difficult to obtain in practice, and estimates involve considerable error sources, so limiting on-farm use. Alternatively, energy balance can be estimated from body reserve changes (EBalbody) using body weight (BW) and body....... Further, the FEC profile did not suggest any systematic bias in EBalbody with stage of lactation. Moreover we successfully modeled EBalbody differences between breeds, parities and diets. For the farmer, the ability to predict energy balance for individual cows on-farm without having to measure feed...

  20. Energy conservation employing membrane-based technology

    International Nuclear Information System (INIS)

    Membranes based processes, if properly adapted to industrial processes have good potential with regard to optimisation and economisation of energy consumption. The specific benefits of MBT (membrane based technology) as an energy conservation methodology are highlighted. (author). 6 refs

  1. Impact on house staff evaluation scores when changing from a Dreyfus- to a Milestone-based evaluation model: one internal medicine residency program’s findings

    OpenAIRE

    Friedman, Karen A.; Balwan, Sandy; Cacace, Frank; Katona, Kyle; Sunday, Suzanne; Chaudhry, Saima

    2014-01-01

    Purpose: As graduate medical education (GME) moves into the Next Accreditation System (NAS), programs must take a critical look at their current models of evaluation and assess how well they align with reporting outcomes. Our objective was to assess the impact on house staff evaluation scores when transitioning from a Dreyfus-based model of evaluation to a Milestone-based model of evaluation. Milestones are a key component of the NAS.Method: We analyzed all end of rotation evaluations of hous...

  2. How non-financial customer based metrics are associated with company performance? An analysis of customer satisfaction, customer retention and Net Promoter Score in Telecommunications Industry

    OpenAIRE

    Husgafvel, Lasse

    2011-01-01

    HOW NON-FINANCIAL CUSTOMER BASED METRICS ARE ASSOCIATED WITH COMPANY PERFORMANCE? AN ANALYSIS OF CUSTOMER SATISFACTION, CUSTOMER RETENTION AND NET PROMOTER SCORE IN TELECOMMUNICATIONS INDUSTRY PURPOSE OF THE STUDY The purpose of this thesis is to examine, how a set of non-financial customer based metrics are associated with company performance. I study how three customer-driven metrics, namely customer satisfaction, customer retention and a customer loyalty measure of Net Promoter Sc...

  3. Fr-TM-align: a new protein structural alignment method based on fragment alignments and the TM-score

    Directory of Open Access Journals (Sweden)

    Skolnick Jeffrey

    2008-12-01

    Full Text Available Abstract Background Protein tertiary structure comparisons are employed in various fields of contemporary structural biology. Most structure comparison methods involve generation of an initial seed alignment, which is extended and/or refined to provide the best structural superposition between a pair of protein structures as assessed by a structure comparison metric. One such metric, the TM-score, was recently introduced to provide a combined structure quality measure of the coordinate root mean square deviation between a pair of structures and coverage. Using the TM-score, the TM-align structure alignment algorithm was developed that was often found to have better accuracy and coverage than the most commonly used structural alignment programs; however, there were a number of situations when this was not true. Results To further improve structure alignment quality, the Fr-TM-align algorithm has been developed where aligned fragment pairs are used to generate the initial seed alignments that are then refined using dynamic programming to maximize the TM-score. For the assessment of the structural alignment quality from Fr-TM-align in comparison to other programs such as CE and TM-align, we examined various alignment quality assessment scores such as PSI and TM-score. The assessment showed that the structural alignment quality from Fr-TM-align is better in comparison to both CE and TM-align. On average, the structural alignments generated using Fr-TM-align have a higher TM-score (~9% and coverage (~7% in comparison to those generated by TM-align. Fr-TM-align uses an exhaustive procedure to generate initial seed alignments. Hence, the algorithm is computationally more expensive than TM-align. Conclusion Fr-TM-align, a new algorithm that employs fragment alignment and assembly provides better structural alignments in comparison to TM-align. The source code and executables of Fr-TM-align are freely downloadable at: http://cssb.biology.gatech.edu/skolnick/files/FrTMalign/.

  4. The effects of police contact on trajectories of violence: a group-based, propensity score matching analysis.

    Science.gov (United States)

    Ward, Jeffrey T; Krohn, Marvin D; Gibson, Chris L

    2014-02-01

    This study uses a life course framework to investigate how police contacts may serve as a potential turning point in a violent crime trajectory. Drawing on the central ideas from deterrence and labeling theories, we determine whether individuals on different violent offending trajectories increase or decrease their offending following a police contact. Analyzing nine waves of data from the Rochester Youth Development Study, an integrated propensity score matching and latent class growth model was used. First, three violent trajectory groups emerged including high offenders, non-offenders, and low offenders. Second, after accounting for selection bias using propensity score matching procedures, experiencing a police contact increased the likelihood of future violent offending for the entire sample and for those who were on a low violent-offending trajectory specifically. These findings are interpreted as partial support for labeling theory. Limitations of the study and directions for future research are discussed. PMID:24142447

  5. Augmentation index is associated with coronary revascularization in patients with high Framingham risk scores: a hospital-based observational study

    OpenAIRE

    Choi, JoonHyouk; Kim, Song-Yi; Joo, Seung-Jae; Kim, Ki-Seok

    2015-01-01

    Background This study analyzed PWAs in patients with high Framingham risk scores to determine whether PWA is predictive of coronary artery disease (CAD) severity and percutaneous coronary intervention (PCI) treatment. Methods In total, 310 patients were screened due to suspected CAD; 78 were excluded due to PCI history (32), atrial fibrillation (11), or acute myocardial infarction (35). The augmentation index (AIx) was analyzed immediately before coronary angiography. PCI was performed in 73 ...

  6. Construction of Pena’s DP2-based ordinal synthetic indicator when partial indicators are rank scores

    OpenAIRE

    Mishra, SK

    2012-01-01

    The present study devises a computational scheme (and develops a FORTRAN 77 computer program) that may be appropriate to construct Pena’s DP2 (ordinal) synthetic indicator (Z) from the partial indicators (X) all of which are ordinal (ranking scores). An attempt has also been made to empirically apply the method (and the computer program) to obtain an ordinal synthetic indicator from a given ordinal data set.

  7. Ultrasonic Elastography Research Based on a Multicenter Study: Adding Strain Ratio after 5-Point Scoring Evaluation or Not.

    Directory of Open Access Journals (Sweden)

    Wen-Jie Mu

    Full Text Available This study aimed to confirm whether strain ratio should be added after evaluation of lesions with 5-point elasticity scoring for differentiating benign and malignant breast lesions on ultrasonographic elastography(UE.From June 2010 to March 2012, 1080 consecutive female patients with breast lesions were recruited into a multicenter retrospective study, which involved 8 centers across China. Each institutional ethic review board approved the study, and all the patients gave written informed consent. All the patients underwent the UE procedure and the strain ratios were calculated and the final diagnosis was made by histological findings. The sensitivity, specificity, accuracy, PPV and NPV were calculated for each of the two evaluation systems and the areas under the ROC curve were compared.The strain ratios of benign lesions (mean, 2.6±2.0 and malignant lesions (mean,7.9±5.8 were significantly different (p 0.05. The strain ratio method shows better a diagnosis performance of the lesions with elasticity score 3 and 4.Although the two UE methods have similar diagnostic performance, separate calculation of the strain ratios seems compulsory, especially for the large solid breast lesions and the lesions with elasticity score 3 and 4.

  8. Ultrasonic Elastography Research Based on a Multicenter Study: Adding Strain Ratio after 5-Point Scoring Evaluation or Not

    Science.gov (United States)

    Yao, Ji-Yi; Li, Lu-Jing; Peng, Yu-lan; Wang, Yi; Liu, Li-sha; Xiao, Ying; Liu, Shou-jun; Wu, Chang-jun; Jiang, Yu-xin; Parajuly, Shyam Sundar; Xu, Ping; Hao, Yi; Li, Jing; Luo, Bao-Ming; Zhi, Hui

    2016-01-01

    Background This study aimed to confirm whether strain ratio should be added after evaluation of lesions with 5-point elasticity scoring for differentiating benign and malignant breast lesions on ultrasonographic elastography(UE). Materials and Methods From June 2010 to March 2012, 1080 consecutive female patients with breast lesions were recruited into a multicenter retrospective study, which involved 8 centers across China. Each institutional ethic review board approved the study, and all the patients gave written informed consent. All the patients underwent the UE procedure and the strain ratios were calculated and the final diagnosis was made by histological findings. The sensitivity, specificity, accuracy, PPV and NPV were calculated for each of the two evaluation systems and the areas under the ROC curve were compared. Results The strain ratios of benign lesions (mean, 2.6±2.0) and malignant lesions (mean,7.9±5.8) were significantly different (p 0.05). The strain ratio method shows better a diagnosis performance of the lesions with elasticity score 3 and 4. Conclusions Although the two UE methods have similar diagnostic performance, separate calculation of the strain ratios seems compulsory, especially for the large solid breast lesions and the lesions with elasticity score 3 and 4. PMID:26863208

  9. The Effects of Teacher and Teacher-librarian High-end Collaboration on Inquiry-based Project Reports and School Monthly Test Scores of Fifth-grade Students

    Directory of Open Access Journals (Sweden)

    Hai-Hon Chen

    2015-07-01

    Full Text Available The purpose of this study was twofold. The first purpose was to establish the high level collaboration of integrated instruction model between social studies teacher and teacher-librarian. The second purpose was to investigate the effects of high-end collaboration on the individual and groups’ inquiry-based project reports, as well as monthly test scores of fifth-grade students. A quasi-experimental method was adopted, two classes of elementary school fifth graders in Tainan Municipal city, Taiwan were used as samples. Students were randomly assigned to experimental conditions by class. Twenty eight students of the experimental group were taught by the collaboration of social studies teacher and teacher-librarian; while 27 students of the controlled group were taught separately by teacher in didactic teaching method. Inquiry-Based Project Record, Inquiry-Based Project Rubrics, and school monthly test scores were used as instruments for collecting data. A t-test and correlation were used to analyze the data. The results indicate that: (1 High-end collaboration model between social studies teacher and teacher-librarian was established and implemented well in the classroom. (2There was a significant difference between the experimental group and the controlled group in individual and groups’ inquiry-based project reports. Students that were taught by the collaborative teachers got both higher inquiry-based project reports’ scores than those that were taught separately by the teachers. Experimental group’s students got higher school monthly test scores than controlled groups. Suggestions for teachers’ high-end collaboration and future researcher are provided in this paper.

  10. Fetal Biophysical Profile Scoring

    Directory of Open Access Journals (Sweden)

    H.R. HaghighatKhah

    2009-01-01

    Full Text Available   "nFetal biophysical profile scoring is a sonographic-based method of fetal assessment first described by Manning and Platt in 1980. "nThe biophysical profile score was developed as a method to integrate real-time observations of the fetus and his/her intrauterine environment in order to more comprehensively assess the fetal condition. These findings must be evaluated in the context of maternal/fetal history (i.e., chronic hypertension, post-dates, intrauterine growth restriction, etc, fetal structural integrity (presence or absence of congenital anomalies, and the functionality of fetal support structures (placental and umbilical cord. For example, acute asphyxia due to placental abruption may result in an absence of the acute variables of the biophysical profile score (fetal breathing movements, fetal movement, fetal tone, and fetal heart rate reactivity with a normal amniotic fluid volume. With post maturity the asphyxial event may be intermittent and chronic resulting in a decrease in amniotic fluid volume, but with the acute variables remaining normal. "nWhile the 5 components of the biophysical profile score have remained unchanged since 1980 (Manning, 1980, the definitions of a normal and abnormal parameter have evolved with increasing experience. "nIn 1984 the definition of oligohydramnios was increased from < 1cm pocket of fluid to < 2.0 x 1.0 cm pocket. Oligohydramnios is now defined as a pocket of amniotic fluid < 2.0 x 2.0 cm (Manning, 1995a "nIf the four ultrasound variables are normal, the accuracy of the biophysical profile score was not found to be significantly improved by adding the non-stress test. As a result, in 1987 the profile score was modified to incorporate the non-stress test only when one of the ultrasound variables was abnormal (Manning 1987. Table 1 outlines the current definitions for quantifying a variable as present or absent. "nEach of the 5 components of the biophysical profile score does not have equal

  11. Randomization to plant-based dietary approaches leads to larger short-term improvements in Dietary Inflammatory Index scores and macronutrient intake compared with diets that contain meat.

    Science.gov (United States)

    Turner-McGrievy, Gabrielle M; Wirth, Michael D; Shivappa, Nitin; Wingard, Ellen E; Fayad, Raja; Wilcox, Sara; Frongillo, Edward A; Hébert, James R

    2015-02-01

    Studies have examined nutrient differences among people following different plant-based diets. However, all of these studies have been observational. The aim of the present study was to examine differences in nutrient intake and Dietary Inflammatory Index (DII) scores among overweight and obese (body mass index 25.0-49.9 kg/m(2)) adults randomized to receive dietary instruction on a vegan (n = 12), vegetarian (n = 13), pescovegetarian (n = 13), semivegetarian (n = 13), or omnivorous (n = 12) diet during a 6-month randomized controlled trial. Nutrient intake, nutrient adequacy, and DII score were assessed via two 24-hour dietary recalls (Automated Self-Administered 24-Hour Dietary Recall) at baseline and at 2 and 6 months. Differences in nutrient intake and the DII were examined using general linear models with follow-up tests at each time point. We hypothesized that individuals randomized to the vegan diet would have lower DII scores and greater improvements in fiber, carbohydrate, fat, saturated fat, and cholesterol at both 2 and 6 months as compared with the other 4 diets. Participants randomized to the vegan diet had significantly greater changes in most macronutrients at both time points, including fat and saturated fat, as well as cholesterol and, at 2 months, fiber, as compared with most of the other diet groups (Ps Vegan, vegetarian, and pescovegetarian participants all saw significant improvements in the DII score as compared with semivegetarian participants at 2 months (Ps vegan and vegetarian diets, should be given consideration. PMID:25532675

  12. The human interactome knowledge base (hint-kb): An integrative human protein interaction database enriched with predicted protein–protein interaction scores using a novel hybrid technique

    KAUST Repository

    Theofilatos, Konstantinos A.

    2013-07-12

    Proteins are the functional components of many cellular processes and the identification of their physical protein–protein interactions (PPIs) is an area of mature academic research. Various databases have been developed containing information about experimentally and computationally detected human PPIs as well as their corresponding annotation data. However, these databases contain many false positive interactions, are partial and only a few of them incorporate data from various sources. To overcome these limitations, we have developed HINT-KB (http://biotools.ceid.upatras.gr/hint-kb/), a knowledge base that integrates data from various sources, provides a user-friendly interface for their retrieval, cal-culatesasetoffeaturesofinterest and computesaconfidence score for every candidate protein interaction. This confidence score is essential for filtering the false positive interactions which are present in existing databases, predicting new protein interactions and measuring the frequency of each true protein interaction. For this reason, a novel machine learning hybrid methodology, called (Evolutionary Kalman Mathematical Modelling—EvoKalMaModel), was used to achieve an accurate and interpretable scoring methodology. The experimental results indicated that the proposed scoring scheme outperforms existing computational methods for the prediction of PPIs.

  13. Postoperative myocardial infarction and cardiac death. Predictive value of dipyridamole-thallium imaging and five clinical scoring systems based on multifactorial analysis

    Energy Technology Data Exchange (ETDEWEB)

    Lette, J.; Waters, D.; Lassonde, J.; Dube, S.; Heyen, F.; Picard, M.; Morin, M. (Maisonneuve-Rosemont Hospital, Montreal (Canada))

    1990-01-01

    Sixty-six patients unable to complete a standard preoperative exercise test because of physical limitations were studied to determine the predictive value of individual clinical parameters, of clinical scoring systems based on multifactorial analysis, and of dipyridamole-thallium imaging before major general and vascular surgery. Study endpoints were limited to postoperative myocardial infarction or cardiac death before hospital discharge. There were nine postoperative cardiac events (seven deaths and two nonfatal infarctions). There was no statistical correlation between cardiac events and preoperative clinical descriptors, including individual clinical parameters, the Dripps-American Surgical Association score, the Goldman Cardiac Risk Index score, the Detsky Modified Cardiac Risk Index score, Eagle's clinical markers of low surgical risk, and the probability of postoperative events as determined by Cooperman's equation. There were no cardiac events in 30 patients with normal dipyridamole-thallium scans or in nine patients with fixed myocardial perfusion defects. Of 21 patients with reversible perfusion defects who underwent surgery, nine had a postoperative cardiac event (sensitivity, 100%; specificity, 43%). In the six other patients with reversible defects, preoperative angiography showed severe coronary disease or cardiomyopathy. Thus in patients unable to complete a standard exercise stress test, postoperative outcome cannot be predicted clinically before major general and vascular surgery, whereas dipyridamole-thallium imaging successfully identified all patients who sustained a postoperative cardiac event.

  14. Postoperative myocardial infarction and cardiac death. Predictive value of dipyridamole-thallium imaging and five clinical scoring systems based on multifactorial analysis

    International Nuclear Information System (INIS)

    Sixty-six patients unable to complete a standard preoperative exercise test because of physical limitations were studied to determine the predictive value of individual clinical parameters, of clinical scoring systems based on multifactorial analysis, and of dipyridamole-thallium imaging before major general and vascular surgery. Study endpoints were limited to postoperative myocardial infarction or cardiac death before hospital discharge. There were nine postoperative cardiac events (seven deaths and two nonfatal infarctions). There was no statistical correlation between cardiac events and preoperative clinical descriptors, including individual clinical parameters, the Dripps-American Surgical Association score, the Goldman Cardiac Risk Index score, the Detsky Modified Cardiac Risk Index score, Eagle's clinical markers of low surgical risk, and the probability of postoperative events as determined by Cooperman's equation. There were no cardiac events in 30 patients with normal dipyridamole-thallium scans or in nine patients with fixed myocardial perfusion defects. Of 21 patients with reversible perfusion defects who underwent surgery, nine had a postoperative cardiac event (sensitivity, 100%; specificity, 43%). In the six other patients with reversible defects, preoperative angiography showed severe coronary disease or cardiomyopathy. Thus in patients unable to complete a standard exercise stress test, postoperative outcome cannot be predicted clinically before major general and vascular surgery, whereas dipyridamole-thallium imaging successfully identified all patients who sustained a postoperative cardiac event

  15. Decompositions of Proper Scores

    CERN Document Server

    Bröcker, Jochen

    2008-01-01

    Scoring rules are an important tool for evaluating the performance of probabilistic forecasts. A popular example is the Brier score, which allows for a decomposition into terms related to the sharpness (or information content) and to the reliability of the forecast. This feature renders the Brier score a very intuitive measure of forecast quality. In this paper, it is demonstrated that all strictly proper scoring rules allow for a similar decomposition into reliability and sharpness related terms. This finding underpins the importance of proper scores and yields further credence to the practice of measuring forecast quality by proper scores. Furthermore, the effect of averaging multiple probabilistic forecasts on the score is discussed. It is well known that the Brier score of a mixture of several forecasts is never worse that the average score of the individual forecasts. This property hinges on the convexity of the Brier score, a property not universal among proper scores. Arguably, this phenomenon portends...

  16. Knee complaints vary with age and gender in the adult population. Population-based reference data for the Knee injury and Osteoarthritis Outcome Score (KOOS)

    OpenAIRE

    Sundén-Lundius Anne; Bergman Stefan; Paradowski Przemyslaw T; Lohmander L Stefan; Roos Ewa M

    2006-01-01

    Abstract Background Self-reported knee complaints may vary with age and gender. Reference data from the adult population would help to better interpret the outcome of interventions due to knee complaints. The objectives of the present study were to describe the variation of self-reported knee pain, function and quality of life with age and gender in the adult population and to establish population-based reference data for the Knee injury and Osteoarthritis Outcome Score (KOOS). Methods Popula...

  17. Updated Genetic Score Based on 34 Confirmed Type 2 Diabetes Loci Is Associated With Diabetes Incidence and Regression to Normoglycemia in the Diabetes Prevention Program

    OpenAIRE

    Hivert, Marie-France; Jablonski, Kathleen A.; Perreault, Leigh; McAteer, Jarred B; Franks, Paul W.; Hamman, Richard F.; Kahn, Steven E.; Haffner, Steven; Knowler, William C.; Saxena, Richa; Meigs, James Benjamin; Altshuler, David Matthew; Florez, Jose Carlos

    2011-01-01

    Objective: Over 30 loci have been associated with risk of type 2 diabetes at genome-wide statistical significance. Genetic risk scores (GRSs) developed from these loci predict diabetes in the general population. We tested if a GRS based on an updated list of 34 type 2 diabetes–associated loci predicted progression to diabetes or regression toward normal glucose regulation (NGR) in the Diabetes Prevention Program (DPP). Research Design and Methods: We genotyped 34 type 2 diabetes–associated va...

  18. Knee complaints vary with age and gender in the adult population. Population-based reference data for the Knee injury and Osteoarthritis Outcome Score (KOOS)

    DEFF Research Database (Denmark)

    Paradowski, Przemyslaw T; Bergman, Stefan; Sundén-Lundius, Anne;

    2006-01-01

    Self-reported knee complaints may vary with age and gender. Reference data from the adult population would help to better interpret the outcome of interventions due to knee complaints. The objectives of the present study were to describe the variation of self-reported knee pain, function and...... quality of life with age and gender in the adult population and to establish population-based reference data for the Knee injury and Osteoarthritis Outcome Score (KOOS)....

  19. A New Local Score Based Method Applied to Behavior-divergent Quail Lines Sequenced in Pools Precisely Detects Selection Signatures on Genes Related to Autism

    OpenAIRE

    Fariello Rico, Maria Inès; Boitard, Simon; Mercier, Sabine; Robelin, David; Faraut, Thomas; Arnould, Cécile; Recoquillay, Julien; Bouchez, Olivier; Salin, Gérald; Dehais, Patrice; Gourichon, David; Leroux, Sophie; Pitel, Frédérique; Leterrier, Christine; San Cristobal, Magali

    2015-01-01

    Detecting genomic footprints of selection is an important step in the understanding of evolution. Accounting for linkage disequilibrium in genome scans allows increasing the detection power, but haplotype-based methods require individual genotypes and are not applicable on pool-sequenced samples. We propose to take advantage of the local score approach to account for linkage disequilibrium, accumulating (possibly small) signals from single markers over a genomic segment, to clearly pinpoint a...

  20. Score level fusion scheme based on adaptive local Gabor features for face-iris-fingerprint multimodal biometric

    Science.gov (United States)

    He, Fei; Liu, Yuanning; Zhu, Xiaodong; Huang, Chun; Han, Ye; Chen, Ying

    2014-05-01

    A multimodal biometric system has been considered a promising technique to overcome the defects of unimodal biometric systems. We have introduced a fusion scheme to gain a better understanding and fusion method for a face-iris-fingerprint multimodal biometric system. In our case, we use particle swarm optimization to train a set of adaptive Gabor filters in order to achieve the proper Gabor basic functions for each modality. For a closer analysis of texture information, two different local Gabor features for each modality are produced by the corresponding Gabor coefficients. Next, all matching scores of the two Gabor features for each modality are projected to a single-scalar score via a trained, supported, vector regression model for a final decision. A large-scale dataset is formed to validate the proposed scheme using the Facial Recognition Technology database-fafb and CASIA-V3-Interval together with FVC2004-DB2a datasets. The experimental results demonstrate that as well as achieving further powerful local Gabor features of multimodalities and obtaining better recognition performance by their fusion strategy, our architecture also outperforms some state-of-the-art individual methods and other fusion approaches for face-iris-fingerprint multimodal biometric systems.

  1. LCA of biomass-based energy systems

    DEFF Research Database (Denmark)

    Tonini, Davide; Astrup, Thomas

    2012-01-01

    Decrease of fossil fuel consumption in the energy sector is an important step towards more sustainable energy production. Environmental impacts related to potential future energy systems in Denmark with high shares of wind and biomass energy were evaluated using life-cycle assessment (LCA). Based...

  2. Propensity Score-Based Approaches to Confounding by Indication in Individual Patient Data Meta-Analysis: Non-Standardized Treatment for Multidrug Resistant Tuberculosis.

    Directory of Open Access Journals (Sweden)

    Gregory J Fox

    Full Text Available In the absence of randomized clinical trials, meta-analysis of individual patient data (IPD from observational studies may provide the most accurate effect estimates for an intervention. However, confounding by indication remains an important concern that can be addressed by incorporating individual patient covariates in different ways. We compared different analytic approaches to account for confounding in IPD from patients treated for multi-drug resistant tuberculosis (MDR-TB.Two antibiotic classes were evaluated, fluoroquinolones--considered the cornerstone of effective MDR-TB treatment--and macrolides, which are known to be safe, yet are ineffective in vitro. The primary outcome was treatment success against treatment failure, relapse or death. Effect estimates were obtained using multivariable and propensity-score based approaches.Fluoroquinolone antibiotics were used in 28 included studies, within which 6,612 patients received a fluoroquinolone and 723 patients did not. Macrolides were used in 15 included studies, within which 459 patients received this class of antibiotics and 3,670 did not. Both standard multivariable regression and propensity score-based methods resulted in similar effect estimates for early and late generation fluoroquinolones, while macrolide antibiotics use was associated with reduced treatment success.In this individual patient data meta-analysis, standard multivariable and propensity-score based methods of adjusting for individual patient covariates for observational studies yielded produced similar effect estimates. Even when adjustment is made for potential confounding, interpretation of adjusted estimates must still consider the potential for residual bias.

  3. Energy performance of windows based on the net energy gain

    DEFF Research Database (Denmark)

    Svendsen, Svend; Kragh, Jesper; Laustsen, Jacob Birck

    2005-01-01

    The paper presents a new method to set up energy performance requirements and energy classes for windows of all dimensions and configurations. The net energy gain of windows is the solar gain minus the heat loss integrated over the heating season. The net energy gain can be calculated for one...... orientation or averaged over different orientations. The averaged value may be used for energy labeling of windows of standard size. Requirements in building codes may also be based on the net energy gain instead of the thermal transmittance of the window. The size and the configuration of the window, i.......e. number of glazing units, have a very large effect on the net energy gain. Therefore the energy labeling or the requirements based on the standard size may not give valid information on the energy performance of windows of non-standard size. The paper presents a method to set up requirements and classes...

  4. Initial dosing regimen of vancomycin to achieve early therapeutic plasma concentration in critically ill patients with MRSA infection based on APACHE II score.

    Science.gov (United States)

    Imaura, Masaharu; Yokoyama, Haruko; Kohata, Yuji; Kanai, Riichiro; Kohyama, Tomoki; Idemitsu, Wataru; Maki, Yuichi; Igarashi, Takashi; Takahashi, Hiroyuki; Kanno, Hiroshi; Yamada, Yasuhiko

    2016-06-01

    It is essential to assure the efficacy of antimicrobials at the initial phase of therapy. However, increasing the volume of distribution (Vd) of hydrophilic antimicrobials in critically ill patients leads to reduced antimicrobial concentration in plasma and tissue, which may adversely affect the efficacy of that therapy. The aim of the present study was to establish a theoretical methodology for setting an appropriate level for initial vancomycin therapy in individual patients based on Acute Physiology and Chronic Health Evaluation (APACHE) II score. We obtained data from patients who received intravenous vancomycin for a suspected or definitively diagnosed Gram-positive bacterial infection within 72 h after admission to the intensive care unit. The Vd and elimination half-life (t 1/2) of vancomycin values were calculated using the Bayesian method, and we investigated the relationship between them and APACHE II score. There were significant correlations between APACHE II scores and Vd/actual body weight (ABW), as well as t 1/2 (r = 0.58, p < 0.05 and r = 0.74, p < 0.01, respectively). Our results suggested that the Vd and t 1/2 of vancomycin could be estimated using the following regression equations using APACHE II score.[Formula: see text] [Formula: see text]We found that APACHE II score was a useful index for predicting the Vd and t 1/2 of vancomycin, and used that to establish an initial vancomycin dosing regimen comprised of initial dose and administration interval for individual patients. PMID:25502612

  5. Measuring energy efficiency: Is energy intensity a good evidence base?

    International Nuclear Information System (INIS)

    Highlights: • Energy intensity measure reflects consumption, not energy efficiency. • Thermodynamic indicators should describe energy efficiency at all levels. • These indicators should have no reference to economic or financial parameters. • A set of energy efficiency indicators should satisfy several basic principles. • There are trade-offs between energy efficiency, power and costs. - Abstract: There is a widespread assumption in energy statistics and econometrics that energy intensity and energy efficiency are equivalent measures of energy performance of economies. The paper points to the discrepancy between the engineering concept of energy efficiency and the energy intensity as it is understood in macroeconomic statistics. This double discrepancy concerns definitions (while engineering concept of energy efficiency is based on the thermodynamic definition, energy intensity includes economic measures) and use. With regard to the latter, the authors conclude that energy intensity can only provide indirect and delayed evidence of technological and engineering energy efficiency of energy conversion processes, which entails shortcomings for management and policymaking. Therefore, we suggest to stop considering subsectoral, sectoral and other levels of energy intensities as aggregates of lower-level energy efficiency. It is suggested that the insufficiency of energy intensity indicators can be compensated with the introduction of thermodynamic indicators describing energy efficiency at the physical, technological, enterprise, sub-sector, sectoral and national levels without references to any economic or financial parameters. Structured statistical data on thermodynamic efficiency is offered as a better option for identifying break-through technologies and technological bottle-necks that constrain efficiency advancements. It is also suggested that macro-level thermodynamic indicators should be based on the thermodynamic first law efficiency and the energy

  6. Anti-inflammatory Dietary Inflammatory Index scores are associated with healthier scores on other dietary indices.

    Science.gov (United States)

    Wirth, Michael D; Hébert, James R; Shivappa, Nitin; Hand, Gregory A; Hurley, Thomas G; Drenowatz, Clemens; McMahon, Daria; Shook, Robin P; Blair, Steven N

    2016-03-01

    Dietary components are important determinants of systemic inflammation, a risk factor for most chronic diseases. The Dietary Inflammatory Index (DII) was developed to assess dietary inflammatory potential. It was hypothesized that anti-inflammatory DII scores would be associated with "healthier" scores on other dietary indices. The Energy Balance Study is an observational study focusing on energy intake and expenditure in young adults; only baseline data were used for this analysis (n=430). The DII, as well as the Healthy Eating Index-2010 (HEI-2010), the Alternative Healthy Eating Index (AHEI), and the Dietary Approaches to Stop Hypertension Index (DASH) were calculated based on one to three 24-hour dietary recalls. General linear models were used to estimate least square means of the AHEI, HEI-2010, and DASH according to DII quartiles. Those with higher (ie, more proinflammatory) DII scores were more likely to be males, have less than a completed college education, and be younger. In addition, those with higher scores for cognitive restraint for eating or drive for thinness had lower (ie, anti-inflammatory) DII scores. Linear regression analyses indicated that as the DII increased, the AHEI, HEI-2010, and DASH dietary indices decreased (ie, became more unhealthy, all Pfactor for chronic disease. PMID:26923507

  7. Care needs and clinical outcomes of older people with dementia: a population-based propensity score-matched cohort study.

    Directory of Open Access Journals (Sweden)

    Fei-Yuan Hsiao

    Full Text Available To explore the healthcare resource utilization, psychotropic drug use and mortality of older people with dementia.A nationwide propensity score-matched cohort study.National Health Insurance Research database.A total of 32,649 elderly people with dementia and their propensity-score matched controls (n=32,649.Outpatient visits, inpatient care, psychotropic drug use, in-hospital mortality and all-cause mortality at 90 and 365 days.Compared to the non-dementia group, a higher proportion of patients with dementia used inpatient services (1 year after index date: 20.91% vs. 9.55%, and the dementia group had more outpatient visits (median [standard deviation]: 7.00 [8.87] vs. 3.00 [8.30]. Furthermore, dementia cases with acute admission had the highest psychotropic drug utilization both at baseline and at the post-index dates (difference-in-differences: all <0.001. Dementia was associated with an increased risk of all-cause mortality (90 days, Odds ratio (OR=1.85 [95%CI 1.67-2.05], p<0.001; 365 days, OR=1.59 [1.50-1.69], p<0.001 and in-hospital mortality (90 days, OR=1.97 [1.71-2.27], p<0.001; 365 days, OR=1.82 [1.61-2.05], p<0.001 compared to matched controls.When older people with dementia are admitted for acute illnesses, they may increase their use of psychotropic agents and their risk of death, particularly in-hospital mortality.

  8. Combinatorial Consensus Scoring for Ligand-Based Virtual Fragment Screening: A Comparative Case Study for Serotonin 5-HT(3)A, Histamine H(1), and Histamine H(4) Receptors.

    Science.gov (United States)

    Schultes, Sabine; Kooistra, Albert J; Vischer, Henry F; Nijmeijer, Saskia; Haaksma, Eric E J; Leurs, Rob; de Esch, Iwan J P; de Graaf, Chris

    2015-05-26

    In the current study we have evaluated the applicability of ligand-based virtual screening (LBVS) methods for the identification of small fragment-like biologically active molecules using different similarity descriptors and different consensus scoring approaches. For this purpose, we have evaluated the performance of 14 chemical similarity descriptors in retrospective virtual screening studies to discriminate fragment-like ligands of three membrane-bound receptors from fragments that are experimentally determined to have no affinity for these proteins (true inactives). We used a complete fragment affinity data set of experimentally determined ligands and inactives for two G protein-coupled receptors (GPCRs), the histamine H1 receptor (H1R) and the histamine H4 receptor (H4R), and one ligand-gated ion channel (LGIC), the serotonin receptor (5-HT3AR), to validate our retrospective virtual screening studies. We have exhaustively tested consensus scoring strategies that combine the results of multiple actives (group fusion) or combine different similarity descriptors (similarity fusion), and for the first time systematically evaluated different combinations of group fusion and similarity fusion approaches. Our studies show that for these three case study protein targets both consensus scoring approaches can increase virtual screening enrichments compared to single chemical similarity search methods. Our cheminformatics analyses recommend to use a combination of both group fusion and similarity fusion for prospective ligand-based virtual fragment screening. PMID:25815783

  9. Music Score for Sticky

    OpenAIRE

    Zhao, Enguang

    2015-01-01

    The thesis is a film composition scoring for the animated documentary film Sticky directed and produced by Jilli Rose, 2013. The film is 20 minutes long and talking about an expedition to the Ball's Pyramid Island, Australia, and the discovery of the stick insect-a type of phasmid which has disappeared on the Lord Howe Island, Australia since 1920, and how to rescue it and preserve it. The music is mainly composed based on orchestra and combining some electronic synthesis instruments with e...

  10. Energy based prediction models for building acoustics

    DEFF Research Database (Denmark)

    Brunskog, Jonas

    2012-01-01

    In order to reach robust and simplified yet accurate prediction models, energy based principle are commonly used in many fields of acoustics, especially in building acoustics. This includes simple energy flow models, the framework of statistical energy analysis (SEA) as well as more elaborated...... principles as, e.g., wave intensity analysis (WIA). The European standards for building acoustic predictions, the EN 12354 series, are based on energy flow and SEA principles. In the present paper, different energy based prediction models are discussed and critically reviewed. Special attention is placed on...

  11. A population-based validation study of the DCIS Score predicting recurrence risk in individuals treated by breast-conserving surgery alone

    OpenAIRE

    Rakovitch, Eileen; Nofech-Mozes, Sharon; Hanna, Wedad; Baehner, Frederick L.; Saskin, Refik; Butler, Steven M.; Tuck, Alan; SenGupta, Sandip; Elavathil, Leela; Jani, Prashant A.; Bonin, Michel; Chang, Martin C; Robertson, Susan J.; Slodkowska, Elzbieta; Fong, Cindy

    2015-01-01

    Validated biomarkers are needed to improve risk assessment and treatment decision-making for women with ductal carcinoma in situ (DCIS) of the breast. The Oncotype DX® DCIS Score (DS) was shown to predict the risk of local recurrence (LR) in individuals with low-risk DCIS treated by breast-conserving surgery (BCS) alone. Our objective was to confirm these results in a larger population-based cohort of individuals. We used an established population-based cohort of individuals diagnosed with DC...

  12. Evaluation of automated attenuation-based tube current adaptation for coronary calcium scoring in MDCT in a cohort of 262 patients

    International Nuclear Information System (INIS)

    The aim of our study was to evaluate attenuation-based tube current adaptation in coronary calcium scoring using ECG-gated multi-detector-row CT (MDCT). A total of 262 patients underwent non-enhanced cardiac MDCT. Group 1 was scanned using a standard protocol with 120 kV and 150 mAseff. Groups 2-4 were scanned using an attenuation-based dose-adaptation template (CARE Dose) with different effective reference mAs settings (150, 180, 210 mAseff). Body-mass index (BMI) and CT-dose index values were calculated for each patient. Image noise and subjective image quality were assessed. Regression analysis was performed, and the variation coefficient of image noise was determined. Compared to the standard scan protocol a dose reduction of 31.1% for group 2 and 20.1% for group 3 was observed. Measurement variation of image noise was smaller for the attenuation-based dose adaptation protocols (group 2-4) (16.2-17.1%) compared to the standard scan protocol (32.3%). Regression analysis of groups 2-4 showed better correlation with improved dose usage based on BMI (all P ≤ 0.001). Median image quality was ''excellent'' in groups 2-4 and ''good'' in group 1. Automated attenuation-based tube current adaptation in coronary calcium scoring is technically feasible, can decrease patient dose, and reduces variation in image noise as a sign of improved dose usage. (orig.)

  13. Final Gleason Score Prediction Using Discriminant Analysis and Support Vector Machine Based on Preoperative Multiparametric MR Imaging of Prostate Cancer at 3T

    Directory of Open Access Journals (Sweden)

    Fusun Citak-Er

    2014-01-01

    Full Text Available Objective. This study aimed at evaluating linear discriminant analysis (LDA and support vector machine (SVM classifiers for estimating final Gleason score preoperatively using multiparametric magnetic resonance imaging (mp-MRI and clinical parameters. Materials and Methods. Thirty-three patients who underwent mp-MRI on a 3T clinical MR scanner and radical prostatectomy were enrolled in this study. The input features for classifiers were age, the presence of a palpable prostate abnormality, prostate specific antigen (PSA level, index lesion size, and Likert scales of T2 weighted MRI (T2w-MRI, diffusion weighted MRI (DW-MRI, and dynamic contrast enhanced MRI (DCE-MRI estimated by an experienced radiologist. SVM based recursive feature elimination (SVM-RFE was used for eliminating features. Principal component analysis (PCA was applied for data uncorrelation. Results. Using a standard PCA before final Gleason score classification resulted in mean sensitivities of 51.19% and 64.37% and mean specificities of 72.71% and 39.90% for LDA and SVM, respectively. Using a Gaussian kernel PCA resulted in mean sensitivities of 86.51% and 87.88% and mean specificities of 63.99% and 56.83% for LDA and SVM, respectively. Conclusion. SVM classifier resulted in a slightly higher sensitivity but a lower specificity than LDA method for final Gleason score prediction for prostate cancer for this limited patient population.

  14. Population-Based Questionnaire Survey on Health Effects of Aircraft Noise on Residents Living around U.S. Airfields in the RYUKYUS—PART II: AN Analysis of the Discriminant Score and the Factor Score

    Science.gov (United States)

    HIRAMATSU, K.; MATSUI, T.; MIYAKITA, T.; ITO, A.; TOKUYAMA, T.; OSADA, Y.; YAMAMOTO, T.

    2002-02-01

    Discriminant function values of psychosomatics and neurosis are calculated using the 12 scale scores of the Todai Health Index, a general health questionnaire, obtained in the survey done around the Kadena and Futenma U.S. airfields in Okinawa, Japan. The total number of answers available for the analysis is 6301. Factor analysis is applied to the 12 scale scores by means of the principal factor method, and Oblimin rotation is done because the factors extracted are considered likely to correlate with each other to a greater or lesser extent. The logistic regression analysis is made with the independent variables of discriminant function (DF) values and factor scores and with the dependent variables of Ldn, age (six levels), sex, occupation (four categories) and the interaction of age and sex. Results indicate that the odds ratio of the DF values regarding psychosomatic disorder and of the score of somatic factor have clear dose-response relationship. The odds ratios of the DF value of neurosis and of the score of the mental factor increase in the area where noise exposure is very intense.

  15. From Rasch scores to regression

    DEFF Research Database (Denmark)

    Christensen, Karl Bang

    2006-01-01

    Rasch models provide a framework for measurement and modelling latent variables. Having measured a latent variable in a population a comparison of groups will often be of interest. For this purpose the use of observed raw scores will often be inadequate because these lack interval scale propertie....... This paper compares two approaches to group comparison: linear regression models using estimated person locations as outcome variables and latent regression models based on the distribution of the score....

  16. Development and Validation of a Preprocedural Risk Score to Predict Access Site Complications After Peripheral Vascular Interventions Based on the Vascular Quality Initiative Database

    Directory of Open Access Journals (Sweden)

    Daniel Ortiz

    2016-01-01

    Full Text Available Purpose: Access site complications following peripheral vascular intervention (PVI are associated with prolonged hospitalization and increased mortality. Prediction of access site complication risk may optimize PVI care; however, there is no tool designed for this. We aimed to create a clinical scoring tool to stratify patients according to their risk of developing access site complications after PVI. Methods: The Society for Vascular Surgery’s Vascular Quality Initiative database yielded 27,997 patients who had undergone PVI at 131 North American centers. Clinically and statistically significant preprocedural risk factors associated with in-hospital, post-PVI access site complications were included in a multivariate logistic regression model, with access site complications as the outcome variable. A predictive model was developed with a random sample of 19,683 (70% PVI procedures and validated in 8,314 (30%. Results: Access site complications occurred in 939 (3.4% patients. The risk tool predictors are female gender, age > 70 years, white race, bedridden ambulatory status, insulin-treated diabetes mellitus, prior minor amputation, procedural indication of claudication, and nonfemoral arterial access site (model c-statistic = 0.638. Of these predictors, insulin-treated diabetes mellitus and prior minor amputation were protective of access site complications. The discriminatory power of the risk model was confirmed by the validation dataset (c-statistic = 0.6139. Higher risk scores correlated with increased frequency of access site complications: 1.9% for low risk, 3.4% for moderate risk and 5.1% for high risk. Conclusions: The proposed clinical risk score based on eight preprocedural characteristics is a tool to stratify patients at risk for post-PVI access site complications. The risk score may assist physicians in identifying patients at risk for access site complications and selection of patients who may benefit from bleeding avoidance

  17. Countries’ Biomedical Publications and Attraction Scores. A PubMed-based assessment [v2; ref status: indexed, http://f1000r.es/5q4

    Directory of Open Access Journals (Sweden)

    Qinyi Xu

    2015-08-01

    Full Text Available Studying publication volumes at the country level is key to understanding and improving a country’s research system. PubMed is a public search engine of publications in all life sciences areas. Here, we show how this search engine can be used to assess the outputs of life science-related research by country. We have measured the numbers of publications during different time periods based on the country of affiliation of the first authors. Moreover, we have designed scores, which we have named Attraction Scores, to appraise the relative focus either toward particular types of studies, such as clinical trials or reviews, or toward specific research areas, such as public health and pharmacogenomics, or toward specific topics, for instance embryonic stem cells; we have also investigated a possible use of these Attraction Scores in connection with regulatory policies. We have weighed the statistics against general indicators such as country populations and gross domestic products (GDP. During the 5-year period 2008-2012, the United States was the country with the highest number of publications and Denmark the one with the highest number of publications per capita. Among the 40 countries with the highest GDPs, Israel had the highest publications-to-GDP ratio. Among the 20 countries with the most publications, Japan had the highest Attraction Score for induced pluripotent stem (iPS cells and Italy the highest proportion of review publications. More than 50% of publications in English were from countries in which English is not the primary language. We show an assorted and extensive collection of rankings and charts that will inform scholars and policymakers in studying and improving the research systems both at the national and international level.

  18. Development of a Korean Diet Score (KDS) and its application assessing adherence to Korean healthy diet based on the Korean Food Guide Wheels.

    Science.gov (United States)

    Lee, Myoungsook; Chae, Soo Wan; Cha, Youn-Soo; Cho, Mi Sook; Oh, Hea Young; Kim, Mi Kyung

    2013-02-01

    The most critical point in the assessment of adherence to dietary guidelines is the development of a practical definition for adherence, such as a dietary pattern score. The purpose of this study was to develop the Korean Diet Score (KDS) based on the Korean Food Balance Wheel and to examine the association of KDS with various lifestyle characteristics and biochemical factors. The dietary data of 5,320 subjects from the 4th Korean National Health and Nutritional Examination Survey were used for the final analysis. The food guide was composed of six food group categories; 'grain dishes', 'fish and meat dishes', 'vegetable dishes', 'fruits', 'milk' and 'oils and sugars'. Based on the recommended serving numbers for each group, the scores measuring adherence to this food guide were calculated from the dietary information from the 24-hour dietary recall questionnaire, and then its correlation with various characteristics was assessed. KDS was significantly associated with several clinical, lifestyle and socioeconomic factors as well as diagnosed disease history. The higher quintile group of KDS showed a significantly lower level in fasting blood glucose, systolic blood pressure, triglycerides, current smoking and drinking as well as higher leisure time activity, house income and education. Furthermore, the KDS quintile group of women was inversely associated with hypertension, osteoporosis and diabetes. A higher KDS quintile was characterized with a higher intake of several critical nutrients, such as Ca, Fe and vitamins as well as a desirable nutrition balance such as the ratio of macronutrients. Our results demonstrate that KDS is a beneficial tool in assessing the adherence to a healthy diet based on the Korean dietary guidelines. We suggest that KDS could be a useful indicator for evaluating the dietary balance of the Korean population. PMID:23424060

  19. A study of the effect of a visual arts-based program on the scores of Jefferson scale for physician empathy

    OpenAIRE

    Yang, Kuang-Tao; Yang, Jen-Hung

    2013-01-01

    Background The effect of visual arts interventions on development of empathy has not been quantitatively investigated. A study was conducted on the effect of a visual arts-based program on the scores of the Jefferson Scale for Physician Empathy (JSPE). Methods A total of 110 clerks (n = 92) and first-year postgraduate residents (PGY1s) (n = 18) participating in the program were recruited into this study. The 4-hr program covered the subjects of learning to interpret paintings, interpreting pa...

  20. Final Gleason Score Prediction Using Discriminant Analysis and Support Vector Machine Based on Preoperative Multiparametric MR Imaging of Prostate Cancer at 3T

    OpenAIRE

    Fusun Citak-Er; Metin Vural; Omer Acar; Tarik Esen; Aslihan Onay; Esin Ozturk-Isik

    2014-01-01

    Research Article Final Gleason Score Prediction Using Discriminant Analysis and Support Vector Machine Based on Preoperative Multiparametric MR Imaging of Prostate Cancer at 3T Fusun Citak-Er,1 Metin Vural,2 Omer Acar,3 Tarik Esen,3,4 Aslihan Onay,2 and Esin Ozturk-Isik5 1Department of Genetics and Bioengineering, Yeditepe University, ˙In¨on¨u Mah., Kayıs¸da˘gı Cad, 26 A˘gustos Yerles¸imi, Atas¸ehir, 34755 Istanbul, Turkey 2Department of Radiology, VKF American Hospita...

  1. Test and Score Data Summary for TOEFL[R] Internet-Based and Paper-Based Tests. January 2008-December 2008 Test Data

    Science.gov (United States)

    Educational Testing Service, 2008

    2008-01-01

    The Test of English as a Foreign Language[TM], better known as TOEFL[R], is designed to measure the English-language proficiency of people whose native language is not English. TOEFL scores are accepted by more than 6,000 colleges, universities, and licensing agencies in 130 countries. The test is also used by governments, and scholarship and…

  2. LCA of biomass-based energy systems

    DEFF Research Database (Denmark)

    Tonini, Davide; Astrup, Thomas Fruergaard

    2012-01-01

    Decrease of fossil fuel consumption in the energy sector is an important step towards more sustainable energy production. Environmental impacts related to potential future energy systems in Denmark with high shares of wind and biomass energy were evaluated using life-cycle assessment (LCA). Based...... on the reference year 2008, energy scenarios for 2030 and 2050 were assessed. For 2050 three alternatives for supply of transport fuels were considered: (1) fossil fuels, (2) rapeseed based biodiesel, and (3) Fischer–Tropsch based biodiesel. Overall, the results showed that greenhouse gas emissions......–2100 × 106 m2/PJ depending on the amounts and types of energy crops introduced. Use of fossil diesel in the transport sector appeared to be environmentally preferable over biodiesel for acidification, aquatic eutrophication and land occupation. For global warming, biodiesel production via Fischer–Tropsch was...

  3. Integrated energy systems based on cascade utilization of energy

    Energy Technology Data Exchange (ETDEWEB)

    Jin Hongguang; Gao Lin; Han Wei; Li Bingyu; Feng Zhibing [Chinese Academy of Sciences, Beijing (China). Institute of Engineering Thermophysics

    2007-02-15

    Focusing on the traditional principle of physical energy utilization, new integration concepts for combined cooling, heating and power (CCHP) system were identified, and corresponding systems were investigated. Furthermore, the principle of cascade utilization of both chemical and physical energy in energy systems with the integration of chemical processes and thermal cycles was introduced, along with a general equation describing the interrelationship among energy levels of substance, Gibbs free energy of chemical reaction and physical energy. On the basis of this principle, a polygeneration system for power and liquid fuel (methanol) production has been presented and investigated. This system innovatively integrates a fresh gas preparation subsystem without composition adjustment process (NA) and a methanol synthesis subsystem with partial-recycle scheme (PR). Meanwhile, a multi-functional energy system (MES) that consumes coal and natural gas as fuels simultaneously, and co-generates methanol and power, has been presented. In the MES, coal and natural gas are utilized synthetically based on the method of dual-fuel reforming, which integrates methane/steam reforming and coal combustion. Compared with conventional energy systems that do not consider cascade utilization of chemical energy, both of these systems provide superior performance, whose energy saving ratio can be as high as 10%-15%. With special attention paid to chemical energy utilization, the integration features of these two systems have been revealed, and the important role that the principle of cascade utilization of both chemical and physical energy plays in system integration has been identified.

  4. Ligand Identification Scoring Algorithm (LISA)

    Science.gov (United States)

    Zheng, Zheng; Merz, Kenneth M.

    2011-01-01

    A central problem in de novo drug design is determining the binding affinity of a ligand with a receptor. A new scoring algorithm is presented that estimates the binding affinity of a protein-ligand complex given a three-dimensional structure. The method, LISA (Ligand Identification Scoring Algorithm), uses an empirical scoring function to describe the binding free energy. Interaction terms have been designed to account for van der Waals (VDW) contacts, hydrogen bonding, desolvation effects and metal chelation to model the dissociation equilibrium constants using a linear model. Atom types have been introduced to differentiate the parameters for VDW, H-bonding interactions and metal chelation between different atom pairs. A training set of 492 protein-ligand complexes was selected for the fitting process. Different test sets have been examined to evaluate its ability to predict experimentally measured binding affinities. By comparing with other well known scoring functions, the results show that LISA has advantages over many existing scoring functions in simulating protein-ligand binding affinity, especially metalloprotein-ligand binding affinity. Artificial Neural Network (ANN) was also used in order to demonstrate that the energy terms in LISA are well designed and do not require extra cross terms. PMID:21561101

  5. Hybrid Page Scoring Algorithm Based on Centrality and PageRank%基于中心性和PageRank的网页综合评分方法

    Institute of Scientific and Technical Information of China (English)

    乔少杰; 彭京; 李天瑞; 李红; 李太勇; 王超

    2011-01-01

    In order to score Web pages in an effective manner, a new page scoring algorithm, CentralRank, was proposed based on centrality measures, including degree, betweenness and closeness, and the PageRank algorithm. The CentralRank algorithm computes the importance of pages in Web social networks based on the centrality measures and employs the PageRank algorithm to accurately score Web pages. To verify the performance of the CentralRank algorithm, a Web crawler was developed to automatically and effectively crawl Web pages. The Web crawler contains three essential techniques, that is, Web data collection, content analysis and duplicate page detection. Experiments on real data show that the CentralRank algorithm can guarantee less time deficiency and is more exact in scoring Web pages than the centrality measures-based page ranking algorithm and the PageRank algorithm with an average improvement of 14.2% and 7.5% , respectively.%为准确、高效地对网页进行评分,提出了一种基于中心性(结点度、居间度和紧密度)和PageRank算法的网页评分方法CentralRank.它采用PageBank算法计算网页分数,借助中心性度量的方法计算页面在Web社会网络中的重要性.为了验证CentralRank的性能优势,设计了一个网页抓取器,可利用该抓取器自动、准确地下载网页信息.该网页抓取器集成了网络信息采集、页面内容分析和页面消重3项技术.基于大量真实数据的实验结果表明:CentralRank在保证网页评分时间性能的前提下,比单纯基于中心性的网页评分算法和PageBank算法更准确、有效,预测准确性分别提高约14.2%和7.5%.

  6. Evaluation of automated attenuation-based tube current adaptation for coronary calcium scoring in MDCT in a cohort of 262 patients

    Energy Technology Data Exchange (ETDEWEB)

    Muehlenbruch, Georg; Hohl, Christian; Das, Marco; Wildberger, Joachim E.; Thomas, Christoph; Guenther, Rolf W. [University Hospital (RWTH) Aachen, Department of Diagnostic Radiology, Aachen (Germany); Suess, Christoph; Klotz, Ernst; Flohr, Thomas [Siemens Medical Solutions, Computed Tomography, Forchheim (Germany); Koos, Ralf [University Hospital (RWTH) Aachen, Department of Cardiology, Aachen (Germany); Mahnken, Andreas H. [RWTH-Aachen University, Applied Medical Engineering, Helmholtz Institute, Aachen (Germany)

    2007-07-15

    The aim of our study was to evaluate attenuation-based tube current adaptation in coronary calcium scoring using ECG-gated multi-detector-row CT (MDCT). A total of 262 patients underwent non-enhanced cardiac MDCT. Group 1 was scanned using a standard protocol with 120 kV and 150 mAs{sub eff}. Groups 2-4 were scanned using an attenuation-based dose-adaptation template (CARE Dose) with different effective reference mAs settings (150, 180, 210 mAs{sub eff}). Body-mass index (BMI) and CT-dose index values were calculated for each patient. Image noise and subjective image quality were assessed. Regression analysis was performed, and the variation coefficient of image noise was determined. Compared to the standard scan protocol a dose reduction of 31.1% for group 2 and 20.1% for group 3 was observed. Measurement variation of image noise was smaller for the attenuation-based dose adaptation protocols (group 2-4) (16.2-17.1%) compared to the standard scan protocol (32.3%). Regression analysis of groups 2-4 showed better correlation with improved dose usage based on BMI (all P {<=} 0.001). Median image quality was ''excellent'' in groups 2-4 and ''good'' in group 1. Automated attenuation-based tube current adaptation in coronary calcium scoring is technically feasible, can decrease patient dose, and reduces variation in image noise as a sign of improved dose usage. (orig.)

  7. Comparison and combination of a hemodynamics/biomarkers-based model with simplified PESI score for prognostic stratification of acute pulmonary embolism: findings from a real world study

    Directory of Open Access Journals (Sweden)

    Luca Masotti

    2015-11-01

    Full Text Available Background: Prognostic stratification is of utmost importance for management of acute Pulmonary Embolism (PE in clinical practice. Many prognostic models have been proposed, but which is the best prognosticator in real life remains unclear. The aim of our study was to compare and combine the predictive values of the hemodynamics/biomarkers based prognostic model proposed by European Society of Cardiology (ESC in 2008 and simplified PESI score (sPESI. Methods: Data records of 452 patients discharged for acute PE from Internal Medicine wards of Tuscany (Italy were analysed. The ESC model and sPESI were retrospectively calculated and compared by using Areas under Receiver Operating Characteristics (ROC Curves (AUCs and finally the combination of the two models was tested in hemodinamically stable patients. All cause and PE-related in-hospital mortality and fatal or major bleedings were the analyzed endpoints Results: All cause in-hospital mortality was 25% (16.6% PE related in high risk, 8.7% (4.7% in intermediate risk and 3.8% (1.2% in low risk patients according to ESC model. All cause in-hospital mortality was 10.95% (5.75% PE related in patients with sPESI score and #8805;1 and 0% (0% in sPESI score 0. Predictive performance of sPESI was not significantly different compared with 2008 ESC model both for all cause (AUC sPESI 0.711, 95% CI: 0.661-0.758 versus ESC 0.619, 95% CI: 0.567-0.670, difference between AUCs 0.0916, p=0.084 and for PE-related mortality (AUC sPESI 0.764, 95% CI: 0.717-0.808 versus ESC 0.650, 95% CI: 0.598-0.700, difference between AUCs 0.114, p=0.11. Fatal or major bleedings occurred in 4.30% of high risk, 1.60% of intermediate risk and 2.50% of low risk patients according to 2008 ESC model, whereas these occurred in 1.80% of high risk and 1.45% of low risk patients according to sPESI, respectively. Predictive performance for fatal or major bleeding between two models was not significantly different (AUC sPESI 0.658, 95% CI

  8. Importance of the Reorganization Energy Barrier in Computational Design of Porphyrin-Based Solar Cells with Cobalt-Based Redox Mediators

    DEFF Research Database (Denmark)

    Ørnsø, Kristian Baruël; Jónsson, Elvar Örn; Jacobsen, Karsten Wedel;

    2015-01-01

    calculated using ab initio molecular dynamics with explicit solvent. These results are then combined with a Marcus-based extrapolation scheme to obtain the reorganization energies of more than 5000 porphyrin-based dyes. We propose a scheme for scoring the performance of the porphyrin dyes, which is able to...

  9. Use of Framingham risk score and new biomarkers to predict cardiovascular mortality in older people: population based observational cohort study

    OpenAIRE

    de Ruijter, Wouter; Westendorp, Rudi G. J.; Assendelft, Willem J J; Wendy P J den Elzen; Anton J M de Craen; le Cessie, Saskia; Gussekloo, Jacobijn

    2009-01-01

    Objectives To investigate the performance of classic risk factors, and of some new biomarkers, in predicting cardiovascular mortality in very old people from the general population with no history of cardiovascular disease. Design The Leiden 85-plus Study (1997-2004) is an observational prospective cohort study with 5 years of follow-up. Setting General population of the city of Leiden, the Netherlands. Participants Population based sample of participants aged 85 years (215 women and 87 men) ...

  10. Proposal for a New Score-Based Approach To Improve Efficiency of Diagnostic Laboratory Workflow for Acute Bacterial Meningitis in Adults.

    Science.gov (United States)

    Lagi, Filippo; Bartalesi, Filippo; Pecile, Patrizia; Biagioli, Tiziana; Caldini, Anna Lucia; Fanelli, Alessandra; Giannazzo, Giuseppe; Grifoni, Stefano; Massacesi, Luca; Bartoloni, Alessandro; Rossolini, Gian Maria

    2016-07-01

    Microbiological tests on cerebrospinal fluid (CSF) utilize a common urgent-care procedure that does not take into account the chemical and cytological characteristics of the CSF, resulting sometimes in an unnecessary use of human and diagnostic resources. The aim of this study was to retrospectively validate a simple scoring system (bacterial meningitis-Careggi score [BM-CASCO]) based on blood and CSF sample chemical/cytological parameters for evaluating the probability of acute bacterial meningitis (ABM) in adults. BM-CASCO (range, 0 to 6) was defined by the following parameters: CSF cell count, CSF protein levels, CSF lactate levels, CSF glucose-to-serum glucose ratio, and peripheral neutrophil count. BM-CASCO was retrospectively calculated for 784 cases of suspected ABM in adult subjects observed during a four-and-a-half-year-period (2010 to 2014) at the emergency department (ED) of a large tertiary-care teaching hospital in Italy. Among the 28 confirmed ABM cases (3.5%), Streptococcus pneumoniae was the most frequent cause (16 cases). All ABM cases showed a BM-CASCO value of ≥3. Most negative cases (591/756) exhibited a BM-CASCO value of ≤1, which was adopted in our laboratory as a cutoff to not proceed with urgent microbiological analysis of CSF in cases of suspected ABM in adults. During a subsequent 1-year follow-up, the introduction of the BM-CASCO in the diagnostic workflow of ABM in adults resulted in a significant decrease in unnecessary microbiological analysis, with no false negatives. In conclusion, BM-CASCO appears to be an accurate and simple scoring system for optimization of the microbiological diagnostic workflow of ABM in adults. PMID:27170017

  11. MR-sequences for prostate cancer diagnostics: validation based on the PI-RADS scoring system and targeted MR-guided in-bore biopsy

    International Nuclear Information System (INIS)

    This study evaluated the accuracy of MR sequences [T2-, diffusion-weighted, and dynamic contrast-enhanced (T2WI, DWI, and DCE) imaging] at 3T, based on the European Society of Urogenital Radiology (ESUR) scoring system [Prostate Imaging Reporting and Data System (PI-RADS)] using MR-guided in-bore prostate biopsies as reference standard. In 235 consecutive patients [aged 65.7 ± 7.9 years; median prostate-specific antigen (PSA) 8 ng/ml] with multiparametric prostate MRI (mp-MRI), 566 lesions were scored according to PI-RADS. Histology of all lesions was obtained by targeted MR-guided in-bore biopsy. In 200 lesions, biopsy revealed prostate cancer (PCa). The area under the curve (AUC) for cancer detection was 0.70 (T2WI), 0.80 (DWI), and 0.74 (DCE). A combination of T2WI + DWI, T2WI + DCE, and DWI + DCE achieved an AUC of 0.81, 0.78, and 0.79. A summed PI-RADS score of T2WI + DWI + DCE achieved an AUC of 0.81. For higher grade PCa (primary Gleason pattern ≥ 4), the AUC was 0.85 for T2WI + DWI, 0.84 for T2WI + DCE, 0.86 for DWI + DCE, and 0.87 for T2WI + DWI + DCE. The AUC for T2WI + DWI + DCE for transitional-zone PCa was 0.73, and for the peripheral zone 0.88. Regarding higher-grade PCa, AUC for transitional-zone PCa was 0.88, and for peripheral zone 0.96. The combination of T2WI + DWI + DCE achieved the highest test accuracy, especially in patients with higher-grade PCa. The use of ≤2 MR sequences led to lower AUC in higher-grade and peripheral-zone cancers. (orig.)

  12. MR-sequences for prostate cancer diagnostics: validation based on the PI-RADS scoring system and targeted MR-guided in-bore biopsy

    Energy Technology Data Exchange (ETDEWEB)

    Schimmoeller, Lars; Quentin, Michael; Buchbender, Christian; Antoch, Gerald; Blondin, Dirk [University Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, Dusseldorf (Germany); Arsov, Christian; Hiester, Andreas; Rabenalt, Robert; Albers, Peter [University Dusseldorf, Medical Faculty, Department of Urology, Dusseldorf (Germany)

    2014-10-15

    This study evaluated the accuracy of MR sequences [T2-, diffusion-weighted, and dynamic contrast-enhanced (T2WI, DWI, and DCE) imaging] at 3T, based on the European Society of Urogenital Radiology (ESUR) scoring system [Prostate Imaging Reporting and Data System (PI-RADS)] using MR-guided in-bore prostate biopsies as reference standard. In 235 consecutive patients [aged 65.7 ± 7.9 years; median prostate-specific antigen (PSA) 8 ng/ml] with multiparametric prostate MRI (mp-MRI), 566 lesions were scored according to PI-RADS. Histology of all lesions was obtained by targeted MR-guided in-bore biopsy. In 200 lesions, biopsy revealed prostate cancer (PCa). The area under the curve (AUC) for cancer detection was 0.70 (T2WI), 0.80 (DWI), and 0.74 (DCE). A combination of T2WI + DWI, T2WI + DCE, and DWI + DCE achieved an AUC of 0.81, 0.78, and 0.79. A summed PI-RADS score of T2WI + DWI + DCE achieved an AUC of 0.81. For higher grade PCa (primary Gleason pattern ≥ 4), the AUC was 0.85 for T2WI + DWI, 0.84 for T2WI + DCE, 0.86 for DWI + DCE, and 0.87 for T2WI + DWI + DCE. The AUC for T2WI + DWI + DCE for transitional-zone PCa was 0.73, and for the peripheral zone 0.88. Regarding higher-grade PCa, AUC for transitional-zone PCa was 0.88, and for peripheral zone 0.96. The combination of T2WI + DWI + DCE achieved the highest test accuracy, especially in patients with higher-grade PCa. The use of ≤2 MR sequences led to lower AUC in higher-grade and peripheral-zone cancers. (orig.)

  13. Base Program on Energy Related Research

    Energy Technology Data Exchange (ETDEWEB)

    Western Research Institute

    2008-06-30

    The main objective of the Base Research Program was to conduct both fundamental and applied research that will assist industry in developing, deploying, and commercializing efficient, nonpolluting fossil energy technologies that can compete effectively in meeting the energy requirements of the Nation. In that regard, tasks proposed under the WRI research areas were aligned with DOE objectives of secure and reliable energy; clean power generation; development of hydrogen resources; energy efficiency and development of innovative fuels from low and no-cost sources. The goal of the Base Research Program was to develop innovative technology solutions that will: (1) Increase the production of United States energy resources--coal, natural gas, oil, and renewable energy resources; (2) Enhance the competitiveness of United States energy technologies in international markets and assist in technology transfer; (3) Reduce the nation's dependence on foreign energy supplies and strengthen both the United States and regional economies; and (4) Minimize environmental impacts of energy production and utilization. This report summarizes the accomplishments of the overall Base Program. This document represents a stand-alone Final Report for the entire Program. It should be noted that an interim report describing the Program achievements was prepared in 2003 covering the progress made under various tasks completed during the first five years of this Program.

  14. Automatic classification of lung tumour heterogeneity according to a visual-based score system in dynamic contrast enhanced CT sequences

    Science.gov (United States)

    Bevilacqua, Alessandro; Baiocco, Serena

    2016-03-01

    Computed tomography (CT) technologies have been considered for a long time as one of the most effective medical imaging tools for morphological analysis of body parts. Contrast Enhanced CT (CE-CT) also allows emphasising details of tissue structures whose heterogeneity, inspected through visual analysis, conveys crucial information regarding diagnosis and prognosis in several clinical pathologies. Recently, Dynamic CE-CT (DCE-CT) has emerged as a promising technique to perform also functional hemodynamic studies, with wide applications in the oncologic field. DCE-CT is based on repeated scans over time performed after intravenous administration of contrast agent, in order to study the temporal evolution of the tracer in 3D tumour tissue. DCE-CT pushes towards an intensive use of computers to provide automatically quantitative information to be used directly in clinical practice. This requires that visual analysis, representing the gold-standard for CT image interpretation, gains objectivity. This work presents the first automatic approach to quantify and classify the lung tumour heterogeneities based on DCE-CT image sequences, so as it is performed through visual analysis by experts. The approach developed relies on the spatio-temporal indices we devised, which also allow exploiting temporal data that enrich the knowledge of the tissue heterogeneity by providing information regarding the lesion status.

  15. A clinical prognostic scoring system for resectable gastric cancer to predict survival and benefit from paclitaxel- or oxaliplatin-based adjuvant chemotherapy

    Directory of Open Access Journals (Sweden)

    Qian J

    2016-02-01

    Full Text Available Jing Qian,1,* Yingying Qian,1,* Jian Wang,1 Bing Gu,2,3 Dong Pei,1 Shaohua He,1 Fang Zhu,1 Oluf Dimitri Røe,4–7 Jin Xu,8 Lianke Liu,1 Yanhong Gu,1 Renhua Guo,1 Yongmei Yin,1 Yongqian Shu,1 Xiaofeng Chen1 1Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 2Department of Laboratory Medicine, The Affiliated Hospital of Xuzhou Medical College, 3Medical Technology Institute, Xuzhou Medical College, Xuzhou, People’s Republic of China; 4Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology (NTNU, Trondheim, Norway; 5Department of Oncology, Clinical Cancer Research Center, 6Department of Clinical Medicine, Aalborg University Hospital, Aalborg, Denmark; 7Department of Surgery, Cancer Clinic, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway; 8Department of Molecular Cell Biology and Toxicology, Jiangsu Key Lab of Cancer Biomarkers, Prevention & Treatment, Cancer Center, Nanjing Medical University, Nanjing, People’s Republic of China *These authors contributed equally to this work Background: Gastrectomy with D2 lymphadenectomy is a standard procedure of curative resection for gastric cancer (GC. The aim of this study was to develop a simple and reliable prognostic scoring system for GC treated with D2 gastrectomy combined with adjuvant chemotherapy.Methods: A prognostic scoring system was established based on clinical and laboratory data from 579 patients with localized GC without distant metastasis treated with D2 gastrectomy and adjuvant chemotherapy.Results: From the multivariate model for overall survival (OS, five factors were selected for the scoring system: ≥50% metastatic lymph node rate, positive lymphovascular invasion, pathologic TNM Stage II or III, ≥5 ng/mL preoperative carcinoembryonic antigen level, and <110 g/L preoperative hemoglobin. Two models were derived using different methods. Model A identified low- and high

  16. In Vitro Testing of Scaffolds for Mesenchymal Stem Cell-Based Meniscus Tissue Engineering—Introducing a New Biocompatibility Scoring System

    Directory of Open Access Journals (Sweden)

    Felix P. Achatz

    2016-04-01

    Full Text Available A combination of mesenchymal stem cells (MSCs and scaffolds seems to be a promising approach for meniscus repair. To facilitate the search for an appropriate scaffold material a reliable and objective in vitro testing system is essential. This paper introduces a new scoring for this purpose and analyzes a hyaluronic acid (HA gelatin composite scaffold and a polyurethane scaffold in combination with MSCs for tissue engineering of meniscus. The pore quality and interconnectivity of pores of a HA gelatin composite scaffold and a polyurethane scaffold were analyzed by surface photography and Berliner-Blau-BSA-solution vacuum filling. Further the two scaffold materials were vacuum-filled with human MSCs and analyzed by histology and immunohistochemistry after 21 days in chondrogenic media to determine cell distribution and cell survival as well as proteoglycan production, collagen type I and II content. The polyurethane scaffold showed better results than the hyaluronic acid gelatin composite scaffold, with signs of central necrosis in the HA gelatin composite scaffolds. The polyurethane scaffold showed good porosity, excellent pore interconnectivity, good cell distribution and cell survival, as well as an extensive content of proteoglycans and collagen type II. The polyurethane scaffold seems to be a promising biomaterial for a mesenchymal stem cell-based tissue engineering approach for meniscal repair. The new score could be applied as a new standard for in vitro scaffold testing.

  17. Computer-Aided Quantification of Interstitial Lung Disease from High Resolution Computed Tomography Images in Systemic Sclerosis: Correlation with Visual Reader-Based Score and Physiologic Tests

    Directory of Open Access Journals (Sweden)

    Fausto Salaffi

    2015-01-01

    Full Text Available Objective. To evaluate the performance of a computerized-aided method (CaM for quantification of interstitial lung disease (ILD in patients with systemic sclerosis and to determine its correlation with the conventional visual reader-based score (CoVR and the pulmonary function tests (PFTs. Methods. Seventy-nine patients were enrolled. All patients underwent chest high resolution computed tomography (HRCT scored by two radiologists adopting the CoVR. All HRCT images were then analysed by a CaM using a DICOM software. The relationships among the lung segmentation analysis, the readers, and the PFTs results were calculated using linear regression analysis and Pearson’s correlation. Receiver operating curve analysis was performed for determination of CaM extent threshold. Results. A strong correlation between CaM and CoVR was observed (P<0.0001. The CaM showed a significant negative correlation with forced vital capacity (FVC (P<0.0001 and the single breath carbon monoxide diffusing capacity of the lung (DLco (P<0.0001. A CaM optimal extent threshold of 20% represented the best compromise between sensitivity (75.6% and specificity (97.4%. Conclusions. CaM quantification of SSc-ILD can be useful in the assessment of extent of lung disease and may provide reliable tool in daily clinical practice and clinical trials.

  18. Integrated energy systems based on cascade utilization of energy

    Institute of Scientific and Technical Information of China (English)

    JIN Hongguang; LI Bingyu; FENG Zhibing; GAO Lin; HAN Wei

    2007-01-01

    Focusing on the traditional principle of physical energy utilization,new integration concepts for combined cooling,heating and power (CCHP) system were identified,and corresponding systems were investigated.Furthermore,the principle of cascade utilization of both chemical and physical energy in energy systems with the integration of chemical processes and thermal cycles was introduced,along with a general equation describing the interrelationship among energy levels of substance,Gibbs free energy of chemical reaction and physical energy.On the basis of this principle,a polygeneration system for power and liquid fuel (methanol)production has been presented and investigated.This system innovatively integrates a fresh gas preparation subsystem without composition adjustment process (NA) and a methanol synthesis subsystem with partial-recycle scheme (PR).Meanwhile,a multi-functional energy system (MES) that consumes coal and natural gas as fuels simultaneously,and co-generates methanol and power,has been presented.In the MES,coal and natural gas are utilized synthetically based on the method of dual-fuel reforming,which integrates methane/steam reforming and coal combustion.Compared with conventional energy systems that do not consider cascade utilization of chemical energy,both of these systems provide superior performance,whose energy saving ratio can be as high as 10%-15%.With special attention paid to chemical energy utilization,the integration features of these two systems have been revealed,and the important role that the principle of cascade utilization of both chemical and physical energy plays in system integration has been identified.

  19. The Efficiency of Tennis Doubles Scoring Systems

    OpenAIRE

    Geoff Pollard; Graham Pollard

    2010-01-01

    In this paper a family of scoring systems for tennis doubles for testing the hypothesis that pair A is better than pair B versus the alternative hypothesis that pair B is better than A, is established. This family or benchmark of scoring systems can be used as a benchmark against which the efficiency of any doubles scoring system can be assessed. Thus, the formula for the efficiency of any doubles scoring system is derived. As in tennis singles, one scoring system based on the play-the-loser ...

  20. Primary radiotherapy or postoperative radiotherapy in patients with head and neck cancer. Comparative analysis of inflammation-based prognostic scoring systems

    Energy Technology Data Exchange (ETDEWEB)

    Selzer, Edgar; Grah, Anja [Medical University of Vienna, Department of Radiotherapy, Vienna (Austria); Heiduschka, Gregor; Thurnher, Dietmar [Medical University of Vienna, Otorhinolaryngology - Head and Neck Surgery, Vienna (Austria); Kornek, Gabriela [Medical University of Vienna, Medicine I - Division of Clinical Oncology, Vienna (Austria)

    2015-01-13

    Inflammation-based scoring systems have potential value in evaluating the prognosis of cancer patients; however, detailed comparative analyses in well-characterized head and neck cancer patient collectives are missing. We analyzed overall survival (OS) in locally advanced head and neck cancer patients who were treated with curative intent by primary radiotherapy (RT) alone, by RT in combination with cetuximab (RIT) or with cisplatin (RCHT), and by primary surgery followed by postoperative radiotherapy (PORT). The primary RT collective (N = 170) was analyzed separately from the surgery plus RT group (N = 148). OS was estimated using the Kaplan-Meyer method. Cox proportional-hazard regression models were applied to compare the risk of death among patients stratified according to risk factors and the inflammation-based Glasgow Prognostic Score (GPS), the modified GPS (mGPS), the neutrophil-lymphocyte ratio (NLR), the platelet-lymphocyte ratio (PLR), and the prognostic index (PI). A prognostic relevance of the scoring systems for OS was observed in the primarily irradiated, but not in the PORT collective. OS was 35.5, 18.8, and 15.4 months, respectively, according to GPS 0, 1, and 2. OS according to mGPS 0-2 was identical. The PLR scoring system was not of prognostic relevance, while OS was 27.3 months in the NLR 0 group and 17.3 months in the NLR 1 group. OS was 35.5 months in PI 0, 16.1 months in PI 1, and 22.6 months in PI 2. GPS/mGPS scoring systems are able to discriminate between three risk groups in primarily, but not postoperatively irradiated locally advanced head and neck cancer patients. (orig.) [German] Entzuendungsbasierte Bewertungssysteme haben eine potenzielle Bedeutung fuer die Beurteilung der Prognose von Krebspatienten. Derzeit fehlen jedoch ausreichend detailliert durchgefuehrte Analysen in Kollektiven von Patienten mit Kopf-Hals-Tumoren. Untersucht wurde das Gesamtueberleben (''overall survival'', OS) von Patienten mit lokal

  1. Comparison of seven methods for producing Affymetrix expression scores based on False Discovery Rates in disease profiling data

    Directory of Open Access Journals (Sweden)

    Gruber Stephen B

    2005-02-01

    Full Text Available Abstract Background A critical step in processing oligonucleotide microarray data is combining the information in multiple probes to produce a single number that best captures the expression level of a RNA transcript. Several systematic studies comparing multiple methods for array processing have used tightly controlled calibration data sets as the basis for comparison. Here we compare performances for seven processing methods using two data sets originally collected for disease profiling studies. An emphasis is placed on understanding sensitivity for detecting differentially expressed genes in terms of two key statistical determinants: test statistic variability for non-differentially expressed genes, and test statistic size for truly differentially expressed genes. Results In the two data sets considered here, up to seven-fold variation across the processing methods was found in the number of genes detected at a given false discovery rate (FDR. The best performing methods called up to 90% of the same genes differentially expressed, had less variable test statistics under randomization, and had a greater number of large test statistics in the experimental data. Poor performance of one method was directly tied to a tendency to produce highly variable test statistic values under randomization. Based on an overall measure of performance, two of the seven methods (Dchip and a trimmed mean approach are superior in the two data sets considered here. Two other methods (MAS5 and GCRMA-EB are inferior, while results for the other three methods are mixed. Conclusions Choice of processing method has a major impact on differential expression analysis of microarray data. Previously reported performance analyses using tightly controlled calibration data sets are not highly consistent with results reported here using data from human tissue samples. Performance of array processing methods in disease profiling and other realistic biological studies should be

  2. Measuring self-concept of one’s own ability with experiment-based behaviour assessment: towards the construct validity of three scoring variants

    Directory of Open Access Journals (Sweden)

    Martina Frebort

    2011-03-01

    Full Text Available Self-concept of one’s ability is an important construct influencing academic performance (Elliot & Dweck, 2005. The present study deals with the self-concept of one’s domain-specific prior knowledge in Psychology. Here, it is measured indirectly through WITE-Psychology (Frebort, unpublished, a knowledge test that measures Psychology student applicants’ Psychology knowledge. To measure self-concept of one’s domain-specific prior knowledge in Psychology, Wagner-Menghin’s (2004 scoring variant was used. However, this scoring variant entailed certain problems such as disadvantaging able testees under some testing conditions and reducing to the overestimation aspect while neglecting underestimation. The present study suggests two new scoring variants (“alternative tendency” score; “sense of reality” score that overcome the one or the other problematic aspect, respectively. For the original scoring variant (“tendency” score, as well as for the two new scoring variants, unidimensionality is proven through the conditional Likelihood-Ratio test (Andersen, 1973 and graphical model checks. Furthermore, with the correlation coefficient indicating the relationship of each of the three scores to Psychology knowledge, another aspect of construct validity is tested.Results indicate that for one of the two new scoring variants (“sense of reality” score, items do not cover the latent continuum well; the other new scoring variant (“alternative tendency” score is one-dimensional and shows the expected independency of Psychology knowledge. For this reason, it is suggested as a promising alternative to the original scoring variant under certain testing conditions.

  3. Assessing the Impact of School-Based Health Centers on Academic Achievement and College Preparation Efforts: Using Propensity Score Matching to Assess School-Level Data in California.

    Science.gov (United States)

    Bersamin, Melina; Garbers, Samantha; Gaarde, Jenna; Santelli, John

    2016-08-01

    This study examines the association between school-based health center (SBHC) presence and school-wide measures of academic achievement and college preparation efforts. Publicly available educational and demographic data from 810 California public high schools were linked to a list of schools with an SBHC. Propensity score matching, a method to reduce bias inherent in nonrandomized control studies, was used to select comparison schools. Regression analyses, controlling for proportion of English-language learners, were conducted for each outcome including proportion of students participating in three College Board exams, graduation rates, and meeting university graduation requirements. Findings suggest that SBHC presence is positively associated with college preparation outcomes but not with academic achievement outcomes (graduation rates or meeting state graduation requirements). Future research must examine underlying mechanisms supporting this association, such as school connectedness. Additional research should explore the role that SBHC staff could have in supporting college preparation efforts. PMID:27009589

  4. Diagnostic method for lumbar foraminal stenosis based on the clinical results of transforaminal lumbar interbody fusion (TLIF). Utility of the foraminal stenosis score

    International Nuclear Information System (INIS)

    In this study we analyzed 73 cases treated by transforaminal lumbar interbody fusion (TLIF) for lumbar foraminal stenosis or central canal stenosis and foraminal stenosis, and based on the perioperative findings and outcome of treatment, we considered the diagnostic procedure for lumbar foraminal stenosis in the future. In 25 cases (34.2%) cases there was actually no clear perioperative evidence of foraminal stenosis. We compared the preoperative clinical and imaging findings in the group with perioperative findings and the group without perioperative findings performed a multiple logistic regression analysis to identify factors associated with foraminal stenosis. We also calculated the odds ratio for the perioperative findings and proposed a foraminal stenosis scoring system. (author)

  5. FURSMASA: a new approach to rapid scoring functions that uses a MD-averaged potential energy grid and a solvent-accessible surface area term with parameters GA fit to experimental data.

    Science.gov (United States)

    Pearlman, David A; Rao, B Govinda; Charifson, Paul

    2008-05-15

    We demonstrate a new approach to the development of scoring functions through the formulation and parameterization of a new function, which can be used both for rapidly ranking the binding of ligands to proteins and for estimating relative aqueous molecular solubilities. The intent of this work is to introduce a new paradigm for creation of scoring functions, wherein we impose the following criteria upon the function: (1) simple; (2) intuitive; (3) requires no postparameterization tweaking; (4) can be applied (without reparameterization) to multiple target systems; and (5) can be rapidly evaluated for any potential ligand. Following these criteria, a new function, FURSMASA (function for rapid scoring using an MD-averaged grid and the accessible surface area) has been developed. Three novel features of the function include: (1) use of an MD-averaged potential energy grid for ligand-protein interactions, rather than a simple static grid; (2) inclusion of a term that depends on the change in the solvent-accessible surface area changes on an atomic (not molecular) basis; and (3) use of the recently derived predictive index (PI) target when optimizing the function, which focuses the function on its intended purpose of relative ranking. A genetic algorithm is used to optimize the function against test data sets that include ligands for the following proteins: IMPDH, p38, gyrase B, HIV-1, and TACE, as well as the Syracuse Research solubility database. We find that the function is predictive, and can simultaneously fit all the test data sets with cross-validated predictive indices ranging from 0.68 to 0.82. As a test of the ability of this function to predict binding for systems not in the training set, the resulting fitted FURSAMA function is then applied to 23 ligands of the COX-2 enzyme. Comparing the results for COX-2 against those obtained using a variety of well-known rapid scoring functions demonstrates that FURSMASA outperforms all of them in terms of the PI and

  6. CVLEACH: Coverage based energy efficient LEACH algorithm

    Directory of Open Access Journals (Sweden)

    Ankit Thakkar

    2012-06-01

    Full Text Available Designing a protocol stack for wireless sensor network (WSNis a challenging task due to energy, computational and storageconstraints. Energy spent for communication between sensornodes dominates the energy spent for the computation [10].Multi-hop short range communication between wireless sensorsnodes is energy efficient compared to single-hop long rangecommunication. Hierarchical clustering is one of the possiblesolutions to save energy of wireless sensor nodes. Low-EnergyAdaptive Clustering Hierarchy (LEACH, Centralized Low-Energy Adaptive Clustering Hierarchy (LEACH-C andAdvanced Low-Energy Adaptive Clustering Hierarchy(ALEACH are energy efficient hierarchical clustering routingprotocol. In this paper we proposed Coverage based Low-EnergyAdaptive Clustering Hierarchy routing protocol – CVLEACH tomake uniform distribution of Cluster Heads (CHs by creatingnon-overlapped cluster regions using overhearing properties ofthe sensor nodes, which makes the routing protocol more energyefficient and prolongs life time of a wireless sensor network.Simulation results show that CVLEACH improves network lifetime compared to LEACH and ALEACH algorithms.

  7. Reporting Valid and Reliable Overall Scores and Domain Scores

    Science.gov (United States)

    Yao, Lihua

    2010-01-01

    In educational assessment, overall scores obtained by simply averaging a number of domain scores are sometimes reported. However, simply averaging the domain scores ignores the fact that different domains have different score points, that scores from those domains are related, and that at different score points the relationship between overall…

  8. Combination of scoring schemes for protein docking

    Directory of Open Access Journals (Sweden)

    Schomburg Dietmar

    2007-08-01

    Full Text Available Abstract Background Docking algorithms are developed to predict in which orientation two proteins are likely to bind under natural conditions. The currently used methods usually consist of a sampling step followed by a scoring step. We developed a weighted geometric correlation based on optimised atom specific weighting factors and combined them with our previously published amino acid specific scoring and with a comprehensive SVM-based scoring function. Results The scoring with the atom specific weighting factors yields better results than the amino acid specific scoring. In combination with SVM-based scoring functions the percentage of complexes for which a near native structure can be predicted within the top 100 ranks increased from 14% with the geometric scoring to 54% with the combination of all scoring functions. Especially for the enzyme-inhibitor complexes the results of the ranking are excellent. For half of these complexes a near-native structure can be predicted within the first 10 proposed structures and for more than 86% of all enzyme-inhibitor complexes within the first 50 predicted structures. Conclusion We were able to develop a combination of different scoring schemes which considers a series of previously described and some new scoring criteria yielding a remarkable improvement of prediction quality.

  9. APHASIE HANDICAP SCORE

    OpenAIRE

    Detante, Olivier

    2004-01-01

    Stroke is the leading cause of disability for adults. Handicap assessment is required to improve follow-up and for clinical trials. The modified Rankin scale is a "best-seller" which has contributed to prove efficacy of thrombolysis. This global score of disability is simple and patient-oriented. It seems interesting to developp such global scoring for aphasia. Our aim was to validate a simple and reproductible tool for handicap due to every type of aphasia. Aphasia Handicap Score (AHS) was d...

  10. The Bandim tuberculosis score

    DEFF Research Database (Denmark)

    Rudolf, Frauke; Joaquim, Luis Carlos; Vieira, Cesaltina;

    2013-01-01

    Background: This study was carried out in Guinea-Bissau's capital Bissau among inpatients and outpatients attending for tuberculosis (TB) treatment within the study area of the Bandim Health Project, a Health and Demographic Surveillance Site. Our aim was to assess the variability between 2...... physicians in performing the Bandim tuberculosis score (TBscore), a clinical severity score for pulmonary TB (PTB), and to compare it to the Karnofsky performance score (KPS). Method: From December 2008 to July 2009 we assessed the TBscore and the KPS of 100 PTB patients at inclusion in the TB cohort and...

  11. Tariff based value of wind energy

    International Nuclear Information System (INIS)

    In this article an approach for determining a value of wind energy is presented. Calculation is based on wholesale tariffs, i.e. the value of wind energy is defined in comparison with other purchase. This approach can be utilised as an aid in the investment planning in defining the benefits of new wind generation capacity. Linear programming optimization method is used. A case study is presented for different wind scenarios. The value of wind energy can vary remarkably depending on timing of power output. (author)

  12. Tariff based value of wind energy

    Energy Technology Data Exchange (ETDEWEB)

    Raekkoelaeinen, J.; Vilkko, M.; Antila, H.; Lautala, P. [Tampere Univ. of Technology (Finland)

    1995-12-31

    In this article an approach for determining a value of wind energy is presented. Calculation is based on wholesale tariffs, i.e. the value of wind energy is defined in comparison with other purchase. This approach can be utilised as an aid in the investment planning in defining the benefits of new wind generation capacity. Linear programming optimization method is used. A case study is presented for different wind scenarios. The value of wind energy can vary remarkably depending on timing of power output. (author)

  13. A connection between score matching and denoising autoencoders.

    Science.gov (United States)

    Vincent, Pascal

    2011-07-01

    Denoising autoencoders have been previously shown to be competitive alternatives to restricted Boltzmann machines for unsupervised pretraining of each layer of a deep architecture. We show that a simple denoising autoencoder training criterion is equivalent to matching the score (with respect to the data) of a specific energy-based model to that of a nonparametric Parzen density estimator of the data. This yields several useful insights. It defines a proper probabilistic model for the denoising autoencoder technique, which makes it in principle possible to sample from them or rank examples by their energy. It suggests a different way to apply score matching that is related to learning to denoise and does not require computing second derivatives. It justifies the use of tied weights between the encoder and decoder and suggests ways to extend the success of denoising autoencoders to a larger family of energy-based models. PMID:21492012

  14. Evaluated body condition score (bcs) in puerperal period

    OpenAIRE

    Ilir Dova; Ana Kapaj; Enkeleda Ozuni; Imer Haziri

    2013-01-01

    BCS provides an important evaluation of the energy status of cows in puerperal period. This evaluation method provides a subjective indication of the fat cover on cows. To evaluate BCS is used a scoring point system based on the fat deposited in external part of the cow. In this study to evaluate BCS in cows in different farms we used 1 to 9 scoring system. The data shows different BCS classes between cows in different farms. All farms included in study shows that the BCS level is lower than ...

  15. Volleyball Scoring Systems.

    Science.gov (United States)

    Calhoun, William; Dargahi-Noubary, G. R.; Shi, Yixun

    2002-01-01

    The widespread interest in sports in our culture provides an excellent opportunity to catch students' attention in mathematics and statistics classes. One mathematically interesting aspect of volleyball, which can be used to motivate students, is the scoring system. (MM)

  16. Hydrogen based energy storage for solar energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Vanhanen, J.P.; Hagstroem, M.T.; Lund, P.H. [Helsinki Univ. of Technology, Otaniemi (Finland). Dept. of Engineering Physics and Mathematics; Leppaenen, J.R.; Nieminen, J.P. [Neste Oy (Finland)

    1998-12-31

    Hydrogen based energy storage options for solar energy systems was studied in order to improve their overall performance. A 1 kW photovoltaic hydrogen (PV-H2) pilot-plant and commercial prototype were constructed and a numerical simulation program H2PHOTO for system design and optimisation was developed. Furthermore, a comprehensive understanding of conversion (electrolysers and fuel cells) and storage (metal hydrides) technologies was acquired by the project partners. The PV-H{sub 2} power system provides a self-sufficient solution for applications in remote locations far from electric grids and maintenance services. (orig.)

  17. 构建基于过程管理的《高等数学》课平时成绩管理模型%Constructing a Model for Normal Scores Management of Higher Mathematics - Based on the Process Management

    Institute of Scientific and Technical Information of China (English)

    姚伟权

    2011-01-01

    基于教学过程,构建学生平时成绩管理模型,在Excel中用VBA编程,使平时成绩真正做到平时得到、实时统计。%Based on the teaching process, this article constructs a model for normal scores management. It uses VBA in Excel, which makes students' normal scores be recorded on time.

  18. The Objective Borderline Method (OBM): A Probability-Based Model for Setting up an Objective Pass/Fail Cut-Off Score in Medical Programme Assessments

    Science.gov (United States)

    Shulruf, Boaz; Turner, Rolf; Poole, Phillippa; Wilkinson, Tim

    2013-01-01

    The decision to pass or fail a medical student is a "high stakes" one. The aim of this study is to introduce and demonstrate the feasibility and practicality of a new objective standard-setting method for determining the pass/fail cut-off score from borderline grades. Three methods for setting up pass/fail cut-off scores were compared: the…

  19. Pervasive Computing Based Intelligent Energy Conservation System

    OpenAIRE

    Dr. A.Kanagaraj; Ms S.Sharmila

    2015-01-01

    Most of the HVAC system in home is running based on static control algorithm; based on fixed work schedules. In that old system energy became waste when home contains low or no people occupancy. In this paper we presented new dynamic approach of HVAC system control, by combined with pervasive computing. Pervasive computing can be defined as availability of centralized system and information anywhere and anytime. We achieved our target by using occupancy sensors for collecting home status. ...

  20. Adjusting scoring matrices to correct overextended alignments

    OpenAIRE

    Mills, Lauren J.; Pearson, William R.

    2013-01-01

    Motivation: Sequence similarity searches performed with BLAST, SSEARCH and FASTA achieve high sensitivity by using scoring matrices (e.g. BLOSUM62) that target low identity (33% identity). Adjusting the scoring matrix to reflect the identity of the homologous sequence can correct higher identity overextended alignment boundaries. In addition, the scoring matrix that produced a correct alignment could be reliably predicted based on the sequence identity seen in the original BLOSUM62 alignment....

  1. Programming Interactive Music Scores with INScore

    OpenAIRE

    Fober, Dominique; Letz, Stéphane; Orlarey, Yann; Bevilacqua, Frédéric

    2013-01-01

    International audience INScore is an environment for the design of interactive music scores that includes an original event-based interaction system and a scripting language for associating arbitrary messages to these events. We extended the previous version by supporting scripting languages offering a great flexibility in the description of scores and in the interactions with scores. The textual format is directly derived from the OSC message format that was defined in the original INScor...

  2. Weighting Performance Evaluation Criteria Base in Balanced Score Card Approach with Use of Combination Method Shapley value & Bull\\'s-eye

    Directory of Open Access Journals (Sweden)

    Mohammad Hassan Kamfiroozi

    2014-05-01

    Full Text Available Performance evaluation as a control tool was considered by managers in the organizations and manufactures. In this paper we decide to present a new model for performance evaluation and industrial companies ranking at uncertain conditions. Based on this, we implemented performance evaluation based on balance score card (BSC method. Beside, we tried to use three parameter interval grey numbers in lieu of linguistic variables. Then evaluation and weighting of fourth indicators is done with use of Bulls-eye-Shapley combination method that is counted as new approach in this article. Reason of utilization of three parameter interval grey numbers and combination method was decreasing of environmental uncertainty on data and model. This combination weighting method can be used as a new method in decision making Science. At final of this paper case study was implemented on industrial companies (nail makers that ranking of these companies is obtained by use of grey-TOPSIS method (that is a generalization of classic TOPSIS for three parameter interval grey numbers.

  3. Electromagnetic ferrofluid-based energy harvester

    International Nuclear Information System (INIS)

    This Letter investigates the use of ferrofluids for vibratory energy harvesting. In particular, an electromagnetic micro-power generator which utilizes the sloshing of a ferrofluid column in a seismically-excited tank is proposed to transform mechanical motions directly into electricity. Unlike traditional electromagnetic generators that implement a solid magnet, ferrofluids can easily conform to different shapes and respond to very small acceleration levels offering an untapped opportunity to design scalable energy harvesters. The feasibility of the proposed concept is demonstrated and its efficacy is discussed through several experimental studies. -- Highlights: ► A ferrofluid-based electromagnetic energy harvester is proposed and tested. Conformability of fluids offers unique capabilities to design scalable harvesters. ► Power is sensitive to changes in the fluid surface area and external magnetization. ► Device generates 1 microwatt of output power at a base acceleration of 3 m/s2.

  4. Electromagnetic ferrofluid-based energy harvester

    Energy Technology Data Exchange (ETDEWEB)

    Bibo, A.; Masana, R.; King, A.; Li, G. [Nonlinear Vibrations and Energy Harvesting Laboratory (NOVEHL), Department of Mechanical Engineering, Clemson University, Clemson, SC 29634 (United States); Daqaq, M.F., E-mail: mdaqaq@clemson.edu [Nonlinear Vibrations and Energy Harvesting Laboratory (NOVEHL), Department of Mechanical Engineering, Clemson University, Clemson, SC 29634 (United States)

    2012-06-25

    This Letter investigates the use of ferrofluids for vibratory energy harvesting. In particular, an electromagnetic micro-power generator which utilizes the sloshing of a ferrofluid column in a seismically-excited tank is proposed to transform mechanical motions directly into electricity. Unlike traditional electromagnetic generators that implement a solid magnet, ferrofluids can easily conform to different shapes and respond to very small acceleration levels offering an untapped opportunity to design scalable energy harvesters. The feasibility of the proposed concept is demonstrated and its efficacy is discussed through several experimental studies. -- Highlights: ► A ferrofluid-based electromagnetic energy harvester is proposed and tested. Conformability of fluids offers unique capabilities to design scalable harvesters. ► Power is sensitive to changes in the fluid surface area and external magnetization. ► Device generates 1 microwatt of output power at a base acceleration of 3 m/s{sup 2}.

  5. Sustainable urban regeneration based on energy balance

    NARCIS (Netherlands)

    Van Timmeren, A.; Zwetsloot, J.; Brezet, H.; Silvester, S.

    2012-01-01

    In this paper, results are reported of a technology assessment of the use and integration of decentralized energy systems and storage devices in an urban renewal area. First the general context of a different approach based on 'rethinking' and the incorporation of ongoing integration of coming econo

  6. A Novel Risk Score to the Prediction of 10-year Risk for Coronary Artery Disease Among the Elderly in Beijing Based on Competing Risk Model

    Science.gov (United States)

    Liu, Long; Tang, Zhe; Li, Xia; Luo, Yanxia; Guo, Jin; Li, Haibin; Liu, Xiangtong; Tao, Lixin; Yan, Aoshuang; Guo, Xiuhua

    2016-01-01

    Abstract The study aimed to construct a risk prediction model for coronary artery disease (CAD) based on competing risk model among the elderly in Beijing and develop a user-friendly CAD risk score tool. We used competing risk model to evaluate the risk of developing a first CAD event. On the basis of the risk factors that were included in the competing risk model, we constructed the CAD risk prediction model with Cox proportional hazard model. Time-dependent receiver operating characteristic (ROC) curve and time-dependent area under the ROC curve (AUC) were used to evaluate the discrimination ability of the both methods. Calibration plots were applied to assess the calibration ability and adjusted for the competing risk of non-CAD death. Net reclassification index (NRI) and integrated discrimination improvement (IDI) were applied to quantify the improvement contributed by the new risk factors. Internal validation of predictive accuracy was performed using 1000 times of bootstrap re-sampling. Of the 1775 participants without CAD at baseline, 473 incident cases of CAD were documented for a 20-year follow-up. Time-dependent AUCs for men and women at t = 10 years were 0.841 [95% confidence interval (95% CI): 0.806–0.877], 0.804 (95% CI: 0.768–0.839) in Fine and Gray model, 0.784 (95% CI: 0.738–0.830), 0.733 (95% CI: 0.692–0.775) in Cox proportional hazard model. The competing risk model was significantly superior to Cox proportional hazard model on discrimination and calibration. The cut-off values of the risk score that marked the difference between low-risk and high-risk patients were 34 points for men and 30 points for women, which have good sensitivity and specificity. A sex-specific multivariable risk factor algorithm-based competing risk model has been developed on the basis of an elderly Chinese cohort, which could be applied to predict an individual's risk and provide a useful guide to identify the groups at a high risk for CAD among the Chinese

  7. Sustainable Urban Regeneration Based on Energy Balance

    Directory of Open Access Journals (Sweden)

    Sacha Silvester

    2012-07-01

    Full Text Available In this paper, results are reported of a technology assessment of the use and integration of decentralized energy systems and storage devices in an urban renewal area. First the general context of a different approach based on 'rethinking' and the incorporation of ongoing integration of coming economical and environmental interests on infrastructure, in relation to the sustainable urban development and regeneration from the perspective of the tripod people, technology and design is elaborated. However, this is at different scales, starting mainly from the perspective of the urban dynamics. This approach includes a renewed look at the ‘urban metabolism’ and the role of environmental technology, urban ecology and environment behavior focus. Second, the potential benefits of strategic and balanced introduction and use of decentralized devices and electric vehicles (EVs, and attached generation based on renewables are investigated in more detail in the case study of the ‘Merwe-Vierhaven’ area (MW4 in the Rotterdam city port in the Netherlands. In order to optimize the energy balance of this urban renewal area, it is found to be impossible to do this by tuning the energy consumption. It is more effective to change the energy mix and related infrastructures. However, the problem in existing urban areas is that often these areas are restricted to a few energy sources due to lack of available space for integration. Besides this, energy consumption in most cases is relatively concentrated in (existing urban areas. This limits the potential of sustainable urban regeneration based on decentralized systems, because there is no balanced choice regarding the energy mix based on renewables and system optimization. Possible solutions to obtain a balanced energy profile can come from either the choice to not provide all energy locally, or by adding different types of storage devices to the systems. The use of energy balance based on renewables as a

  8. Pervasive Computing Based Intelligent Energy Conservation System

    Directory of Open Access Journals (Sweden)

    Dr. A.Kanagaraj

    2015-11-01

    Full Text Available Most of the HVAC system in home is running based on static control algorithm; based on fixed work schedules. In that old system energy became waste when home contains low or no people occupancy. In this paper we presented new dynamic approach of HVAC system control, by combined with pervasive computing. Pervasive computing can be defined as availability of centralized system and information anywhere and anytime. We achieved our target by using occupancy sensors for collecting home status. Initially our occupancy sensors collect human presence and current HVAC status details and stored in centralized system. Then based on our user defined threshold value the centralized system maintains the building's heating, cooling and air quality conditions by controlling HVAC devices. I.e. this system turned off HVAC systems when a home is unoccupied, or put the system into an energy saving sleep mode when persons are asleep.

  9. Does present use of cardiovascular medication reflect elevated cardiovascular risk scores estimated ten years ago? A population based longitudinal observational study

    Directory of Open Access Journals (Sweden)

    Straand Jørund

    2011-03-01

    Full Text Available Abstract Background It is desirable that those at highest risk of cardiovascular disease should have priority for preventive measures, eg. treatment with prescription drugs to modify their risk. We wanted to investigate to what extent present use of cardiovascular medication (CVM correlates with cardiovascular risk estimated by three different risk scores (Framingham, SCORE and NORRISK ten years ago. Methods Prospective logitudinal observational study of 20 252 participants in The Hordaland Health Study born 1950-57, not using CVM in 1997-99. Prescription data obtained from The Norwegian Prescription Database in 2008. Results 26% of men and 22% of women aged 51-58 years had started to use some CVM during the previous decade. As a group, persons using CVM scored significantly higher on the risk algorithms Framingham, SCORE and NORRISK compared to those not treated. 16-20% of men and 20-22% of women with risk scores below the high-risk thresholds for the three risk scores were treated with CVM, while 60-65% of men and 25-45% of women with scores above the high-risk thresholds received no treatment. Among women using CVM, only 2.2% (NORRISK, 4.4% (SCORE and 14.5% (Framingham had risk scores above the high-risk values. Low education, poor self-reported general health, muscular pains, mental distress (in females only and a family history of premature cardiovascular disease correlated with use of CVM. Elevated blood pressure was the single factor most strongly predictive of CVM treatment. Conclusion Prescription of CVM to middle-aged individuals by large seems to occur independently of estimated total cardiovascular risk, and this applies especially to females.

  10. Evaluering af overensstemmelsen af body condition score og feline body mass index sammenlignet med dual energy X-ray absorptiometry hos katte

    DEFF Research Database (Denmark)

    Falkenberg, Michael; Hølmkjær, Kirsten Madsen; Cronin, Anna;

    2016-01-01

    Formål: Obesitet er et stigende problem blandt katte, og der er derfor brug for nemme, billige og hurtige metoder til vurdering af kattes kropssammensætning i praksis. Indeværende studie sammenligner to klinisk applicerbare metoder: Body condition score (BCS) og feline body mass index (FBMI) mod...

  11. A Scoring Criterion For Learning Chain Graphs

    Institute of Scientific and Technical Information of China (English)

    Zhong Guo ZHENG; Jing XU; Xing Wei TONG

    2006-01-01

    A chain graph allows both directed and undirected edges, and contains the underlying mathematical properties of the two. An important method of learning graphical models is to use scoring criteria to measure how well the graph structures fit the data. In this paper, we present a scoring criterion for learning chain graphs based on the Kullback-Leibler distance. It is score equivalent, that is, equivalent chain graphs obtain the same score, so it can be used to perform model selection and model averaging.

  12. [The diagnostic scores for deep venous thrombosis].

    Science.gov (United States)

    Junod, A

    2015-08-26

    Seven diagnostic scores for the deep venous thrombosis (DVT) of lower limbs are analyzed and compared. Two features make this exer- cise difficult: the problem of distal DVT and of their proximal extension and the status of patients, whether out- or in-patients. The most popular score is the Wells score (1997), modi- fied in 2003. It includes one subjective ele- ment based on clinical judgment. The Primary Care score 12005), less known, has similar pro- perties, but uses only objective data. The pre- sent trend is to associate clinical scores with the dosage of D-Dimers to rule out with a good sensitivity the probability of TVP. For the upper limb DVT, the Constans score (2008) is available, which can also be coupled with D-Dimers testing (Kleinjan). PMID:26502582

  13. Random Walk Picture of Basketball Scoring

    CERN Document Server

    Gabel, Alan

    2011-01-01

    We present evidence, based on play-by-play data from all 6087 games from the 2006/07--2009/10 seasons of the National Basketball Association (NBA), that basketball scoring is well described by a weakly-biased continuous-time random walk. The time between successive scoring events follows an exponential distribution, with little memory between different scoring intervals. Using this random-walk picture that is augmented by features idiosyncratic to basketball, we account for a wide variety of statistical properties of scoring, such as the distribution of the score difference between opponents and the fraction of game time that one team is in the lead. By further including the heterogeneity of team strengths, we build a computational model that accounts for essentially all statistical features of game scoring data and season win/loss records of each team.

  14. APHASIE HANDICAP SCORE

    OpenAIRE

    Detante, Olivier

    2004-01-01

    L'accident vasculaire cérébral (AVC) est la principale cause de handicap de l'adule dont la quantification est indispensable à l'évaluation de la qualité des soins. Le score de Rankin est un " best-seller " qui a contribué à démontrer l'efficacité de la thrombolyse. Ce score global du handicap est simple et le plus " patient-orienté " des scores actuels. Il nous a semblé intéressant d'adapter cette approche globale du handicap post-AVC au problème spécifique des aphasies. L'objectif était de ...

  15. Team Performance with Test Scores

    OpenAIRE

    Kleinberg, Jon; Raghu, Maithra

    2015-01-01

    Team performance is a ubiquitous area of inquiry in the social sciences, and it motivates the problem of team selection -- choosing the members of a team for maximum performance. Influential work of Hong and Page has argued that testing individuals in isolation and then assembling the highest-scoring ones into a team is not an effective method for team selection. For a broad class of performance measures, based on the expected maximum of random variables representing individual candidates, we...

  16. Who puts the most energy into energy conservation? A segmentation of energy consumers based on energy-related behavioral characteristics

    International Nuclear Information System (INIS)

    The present paper aims to identify and describe different types of energy consumers in a more comprehensive way than previous segmentation studies using cluster analysis. Energy consumers were segmented based on their energy-related behavioral characteristics. In addition to purchase- and curtailment-related energy-saving behavior, consumer classification was also based on acceptance of policy measures and energy-related psychosocial factors, so the used behavioral segmentation base was more comprehensive compared to other studies. Furthermore, differentiation between the energy-saving purchase of daily products, such as food, and of energy efficient appliances allowed a more differentiated characterization of the energy consumer segments. The cluster analysis revealed six energy consumer segments: the idealistic, the selfless inconsequent, the thrifty, the materialistic, the convenience-oriented indifferent, and the problem-aware well-being-oriented energy consumer. Findings emphasize that using a broader and more distinct behavioral base is crucial for an adequate and differentiated description of energy consumer types. The paper concludes by highlighting the most promising energy consumer segments and discussing possible segment-specific marketing and policy strategies. - Highlights: ► By applying a cluster-analytic approach, new energy consumer segments are identified. ► A comprehensive, differentiated description of the different energy consumer types is provided. ► A distinction between purchase of daily products and energy efficient appliances is essential. ► Behavioral variables are a more suitable base for segmentation than general characteristics.

  17. Instant MuseScore

    CERN Document Server

    Shinn, Maxwell

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. Instant MuseScore is written in an easy-to follow format, packed with illustrations that will help you get started with this music composition software.This book is for musicians who would like to learn how to notate music digitally with MuseScore. Readers should already have some knowledge about musical terminology; however, no prior experience with music notation software is necessary.

  18. School Enrollment, Selection and Test Scores

    OpenAIRE

    Filmer, Deon; Schady, Norbert

    2009-01-01

    There is a strong association between schooling attained and test scores in many settings. If this association is causal, one might expect that programs that increase school enrollment and attainment would also improve test scores. However, if there is self-selection into school based on expected gains, marginal children brought into school by such programs may be drawn disproportionately from ...

  19. Is scoring system of computed tomography based metric parameters can accurately predicts shock wave lithotripsy stone-free rates and aid in the development of treatment strategies?

    Directory of Open Access Journals (Sweden)

    Yasser ALI Badran

    2016-01-01

    Conclusion: Stone size, stone density (HU, and SSD is simple to calculate and can be reported by radiologists to applying combined score help to augment predictive power of SWL, reduce cost, and improving of treatment strategies.

  20. Stroke mortality: predictive value of simple laboratory tests and acute physiology, age, chronic health evaluation III scoring system: a hospital based study

    OpenAIRE

    Ajeet K. Chaurasia; Manoj K. Mathur; N C Dwivedi; Manjul Mishra

    2016-01-01

    Background: Acute stroke is a heterogeneous condition with respect to prognosis. This study was undertaken with the aim to evaluate the significance of routine simple blood parameters and APACHE (acute physiology, age, chronic health evaluation) III scoring system as methods of prediction of 1-month mortality in stroke patients and to assess the sensitivity and specificity of APACHE III scoring system in predicting short term outcome in critically ill patients having stroke. Methods: Patie...

  1. Technological change of the energy innovation system: From oil-based to bio-based energy

    Energy Technology Data Exchange (ETDEWEB)

    Wonglimpiyarat, Jarunee [College of Innovation, Thammasat University, Anekprasong Building 7th Fl., Prachan Rd., Bangkok 10200 (Thailand)

    2010-03-15

    This paper concerns the structural developments and the direction of technological change of the energy innovation system, based on the studies of Kuhn's model of scientific change and Schumpeter's model of technological change. The paper uses the case study of Thai government agencies for understanding the way governments can facilitate technological innovation. The analyses are based on a pre-foresight exercise to examine the potential of the bio-based energy and investigate a set of development policies necessary for the direction of energy system development. The results have shown that bio-based energy is seen as the next new wave for future businesses and one of the solutions to the problem of high oil prices to improve the world's economic security and sustainable development. (author)

  2. Developing Scoring Algorithms

    Science.gov (United States)

    We developed scoring procedures to convert screener responses to estimates of individual dietary intake for fruits and vegetables, dairy, added sugars, whole grains, fiber, and calcium using the What We Eat in America 24-hour dietary recall data from the 2003-2006 NHANES.

  3. Bluetooth low energy based ticketing systems

    OpenAIRE

    Kuchimanchi, Sriharsha

    2015-01-01

    This thesis proposes a Bluetooth Low Energy (BLE) based payment solution for public transportation. The thesis first reviews some of the ‘Mobile payment solutions´. Traditionally, these services have revolved around technologies like Barcodes, Quick Response (QR) codes, Short Messaging Services (SMS) etc. However, with the advent of smartphones equipped with Bluetooth controllers and security chips, a number of innovative payment services are being studied. Furthermore, this thesis a...

  4. Sustainable Urban Regeneration Based on Energy Balance

    OpenAIRE

    Sacha Silvester; Han Brezet; Arjan van Timmeren; Jonna Zwetsloot

    2012-01-01

    In this paper, results are reported of a technology assessment of the use and integration of decentralized energy systems and storage devices in an urban renewal area. First the general context of a different approach based on 'rethinking' and the incorporation of ongoing integration of coming economical and environmental interests on infrastructure, in relation to the sustainable urban development and regeneration from the perspective of the tripod people, technology and design is ...

  5. REDUCED ENERGY CONSUMPTION THROUGH PROJECTILE BASED EXCAVATION

    Energy Technology Data Exchange (ETDEWEB)

    Mark Machina

    2002-10-12

    The Projectile Based Excavation (ProjEX) program has as its goal, the reduction of energy required for production mining and secondary breakage through the use of a projectile based excavation system. It depends on the development of a low cost family of projectiles that will penetrate and break up different types of ore/rock and a low cost electric launch system. The electric launch system will eliminate the need for high cost propellant investigated for similar concepts in the past. This document reports on the progress made in the program during the past quarter. It reports on projectile development and the development of the electric launch system design.

  6. Ferrofluid based micro-electrical energy harvesting

    Science.gov (United States)

    Purohit, Viswas; Mazumder, Baishakhi; Jena, Grishma; Mishra, Madhusha; Materials Department, University of California, Santa Barbara, CA93106 Collaboration

    2013-03-01

    Innovations in energy harvesting have seen a quantum leap in the last decade. With the introduction of low energy devices in the market, micro energy harvesting units are being explored with much vigor. One of the recent areas of micro energy scavenging is the exploitation of existing vibrational energy and the use of various mechanical motions for the same, useful for low power consumption devices. Ferrofluids are liquids containing magnetic materials having nano-scale permanent magnetic dipoles. The present work explores the possibility of the use of this property for generation of electricity. Since the power generation is through a liquid material, it can take any shape as well as response to small acceleration levels. In this work, an electromagnet-based micropower generator is proposed to utilize the sloshing of the ferrofluid within a controlled chamber which moves to different low frequencies. As compared to permanent magnet units researched previously, ferrofluids can be placed in the smallest of containers of different shapes, thereby giving an output in response to the slightest change in motion. Mechanical motion from 1- 20 Hz was able to give an output voltage in mV's. In this paper, the efficiency and feasibility of such a system is demonstrated.

  7. Fiber intake, not dietary energy density, is associated with subsequent change in BMI z-score among sub-groups of children

    DEFF Research Database (Denmark)

    Kring, Sofia I Iqbal; Heitmann, Berit L

    2008-01-01

    OBJECTIVE: Results from short-term studies demonstrate that energy density influences energy intake, but in children and adolescents the long-term effects of energy density and obesity development are sparse. We examined the longitudinal relationship between dietary energy density, fiber intake, ...

  8. Effects of Adolescent Childbearing on Maternal Depression and Problem Behaviors: A Prospective, Population-Based Study Using Risk-Set Propensity Scores

    Science.gov (United States)

    Murray, Joseph; Xiong, Shuangyan; Stepp, Stephanie D.; Keenan, Kate E.

    2016-01-01

    Adolescent mothers are reportedly at risk for depression and problem behaviors in the postpartum period, but studies have rarely considered developmental context and have yet to disentangle the effects of childbearing on adolescent functioning from selection effects that are associated with early pregnancy. The current study examined changes in adolescent depression, conduct problems and substance use (alcohol, tobacco and marijuana) across the peripartum period using risk-set propensity scores derived from a population-based, prospective study that began in childhood (the Pittsburgh Girls Study, PGS). Each of 147 childbearing adolescents (ages 12–19) was matched with two same-age, non-childbearing adolescents (n = 294) on pregnancy propensity using 15 time-varying risk variables derived from sociodemographic, psychopathology, substance use, family, peer and neighborhood domains assessed in the PGS wave prior to each pregnancy (T1). Postpartum depression and problem behaviors were assessed within the first 6 months following delivery (T2); data gathered from the non-childbearing adolescent controls spanned the same interval. Within the childbearing group, conduct problems and marijuana use reduced from T1 to T2, but depression severity and frequency of alcohol or tobacco use showed no change. When change was compared across the matched groups, conduct problems showed a greater reduction among childbearing adolescents. Relative to non-childbearing adolescents who reported more frequent substance use with time, childbearing adolescents reported no change in alcohol use and less frequent use of marijuana across the peripartum period. There were no group differences in patterns of change for depression severity and tobacco use. The results do not support the notion that adolescent childbearing represents a period of heightened risk for depression or problem behaviors. PMID:27176826

  9. Effects of Adolescent Childbearing on Maternal Depression and Problem Behaviors: A Prospective, Population-Based Study Using Risk-Set Propensity Scores.

    Directory of Open Access Journals (Sweden)

    Alison E Hipwell

    Full Text Available Adolescent mothers are reportedly at risk for depression and problem behaviors in the postpartum period, but studies have rarely considered developmental context and have yet to disentangle the effects of childbearing on adolescent functioning from selection effects that are associated with early pregnancy. The current study examined changes in adolescent depression, conduct problems and substance use (alcohol, tobacco and marijuana across the peripartum period using risk-set propensity scores derived from a population-based, prospective study that began in childhood (the Pittsburgh Girls Study, PGS. Each of 147 childbearing adolescents (ages 12-19 was matched with two same-age, non-childbearing adolescents (n = 294 on pregnancy propensity using 15 time-varying risk variables derived from sociodemographic, psychopathology, substance use, family, peer and neighborhood domains assessed in the PGS wave prior to each pregnancy (T1. Postpartum depression and problem behaviors were assessed within the first 6 months following delivery (T2; data gathered from the non-childbearing adolescent controls spanned the same interval. Within the childbearing group, conduct problems and marijuana use reduced from T1 to T2, but depression severity and frequency of alcohol or tobacco use showed no change. When change was compared across the matched groups, conduct problems showed a greater reduction among childbearing adolescents. Relative to non-childbearing adolescents who reported more frequent substance use with time, childbearing adolescents reported no change in alcohol use and less frequent use of marijuana across the peripartum period. There were no group differences in patterns of change for depression severity and tobacco use. The results do not support the notion that adolescent childbearing represents a period of heightened risk for depression or problem behaviors.

  10. Cantilever-based electret energy harvesters

    International Nuclear Information System (INIS)

    Integration of structures and functions has permitted the electricity consumption of sensors, actuators and electronic devices to be reduced. Therefore, it is now possible to imagine low-consumption devices able to harvest energy from their surrounding environment. One way to proceed is to develop converters able to turn mechanical energy, such as vibrations, into electricity: this paper focuses on electrostatic converters using electrets. We develop an accurate analytical model of a simple but efficient cantilever-based electret energy harvester. We prove that with vibrations of 0.1g (∼1 m s−2), it is theoretically possible to harvest up to 30 µW per gram of mobile mass. This power corresponds to the maximum output power of a resonant energy harvester according to the model of William and Yates. Simulation results are validated by experimental measurements, raising at the same time the large impact of parasitic capacitances on the output power. Therefore, we 'only' managed to harvest 10 µW per gram of mobile mass, but according to our factor of merit, this is among the best results so far achieved

  11. The genetics of alcohol dependence: Twin and SNP-based heritability, and genome-wide association study based on AUDIT scores.

    Science.gov (United States)

    Mbarek, Hamdi; Milaneschi, Yuri; Fedko, Iryna O; Hottenga, Jouke-Jan; de Moor, Marleen H M; Jansen, Rick; Gelernter, Joel; Sherva, Richard; Willemsen, Gonneke; Boomsma, Dorret I; Penninx, Brenda W; Vink, Jacqueline M

    2015-12-01

    Alcohol dependence (AD) is among the most common and costly public health problems contributing to morbidity and mortality throughout the world. In this study, we investigate the genetic basis of AD in a Dutch population using data from the Netherlands Twin Register (NTR) and the Netherlands Study of Depression and Anxiety (NESDA). The presence of AD was ascertained via the Alcohol Use Disorders Identification Test (AUDIT) applying cut-offs with good specificity and sensitivity in identifying those at risk for AD. Twin-based heritability of AD-AUDIT was estimated using structural equation modeling of data in 7,694 MZ and DZ twin pairs. Variance in AD-AUDIT explained by all SNPs was estimated with genome-wide complex trait analysis (GCTA). A genome-wide association study (GWAS) was performed in 7,842 subjects. GWAS SNP effect concordance analysis was performed between our GWAS and a recent AD GWAS using DSM-IV diagnosis. The twin-based heritability of AD-AUDIT was estimated at 60% (55-69%). GCTA showed that common SNPs jointly capture 33% (SE = 0.12, P = 0.002) of this heritability. In the GWAS, the top hits were positioned within four regions (4q31.1, 2p16.1, 6q25.1, 7p14.1) with the strongest association detected for rs55768019 (P = 7.58 × 10(-7) ). This first GWAS of AD using the AUDIT measure found results consistent with previous genetic studies using DSM diagnosis: concordance in heritability estimates and direction of SNPs effect and overlap with top hits from previous GWAS. Thus, the use of appropriate questionnaires may represent cost-effective strategies to phenotype samples in large-scale biobanks or other population-based datasets. PMID:26365420

  12. Validation of a Body Condition Scoring System in Rhesus Macaques (Macaca mulatta): Assessment of Body Composition by using Dual-Energy X-ray Absorptiometry

    OpenAIRE

    Summers, Laura; Clingerman, Karen J; Yang, Xiaowei

    2012-01-01

    Body condition scoring (BCS) is a subjective semiquantitative method of assessing body fat and muscle by palpation of key anatomic features. A previously published BCS system for rhesus macaques (Macaca mulatta) uses a scale comprising both whole and half units, in which the midrange represents optimal body condition (3.0), lower values represent emaciated to lean conditions (1.0 to 2.0), and higher values (4.0 to 5.0) indicate excessive body fat. A valid BCS system is well described, relevan...

  13. Prevalence of swallowing and speech problems in daily life after chemoradiation for head and neck cancer based on cut-off scores of the patient-reported outcome measures SWAL-QOL and SHI

    NARCIS (Netherlands)

    Rinkel, Rico N; Verdonck-de Leeuw, Irma M; Doornaert, Patricia; Buter, Jan; de Bree, Remco; Langendijk, Johannes A; Aaronson, Neil K; Leemans, C René

    2015-01-01

    The objective of this study is to assess swallowing and speech outcome after chemoradiation therapy for head and neck cancer, based on the patient-reported outcome measures Swallowing Quality of Life Questionnaire (SWAL-QOL) and Speech Handicap Index (SHI), both provided with cut-off scores. This is

  14. Prevalence of swallowing and speech problems in daily life after chemoradiation for head and neck cancer based on cut-off scores of the patient-reported outcome measures SWAL-QOL and SHI

    NARCIS (Netherlands)

    Rinkel, Rico N.; Verdonck-de Leeuw, Irma M.; Doornaert, Patricia; Buter, Jan; de Bree, Remco; Langendijk, Johannes A.; Aaronson, Neil K.; Leemans, C. Rene

    2016-01-01

    The objective of this study is to assess swallowing and speech outcome after chemoradiation therapy for head and neck cancer, based on the patient-reported outcome measures Swallowing Quality of Life Questionnaire (SWAL-QOL) and Speech Handicap Index (SHI), both provided with cut-off scores. This is

  15. Performance of Fourth-Grade Students in the 2012 NAEP Computer-Based Writing Pilot Assessment: Scores, Text Length, and Use of Editing Tools. Working Paper Series. NCES 2015-119

    Science.gov (United States)

    White, Sheida; Kim, Young Yee; Chen, Jing; Liu, Fei

    2015-01-01

    This study examined whether or not fourth-graders could fully demonstrate their writing skills on the computer and factors associated with their performance on the National Assessment of Educational Progress (NAEP) computer-based writing assessment. The results suggest that high-performing fourth-graders (those who scored in the upper 20 percent…

  16. Inductive energy transfer system based on drone

    OpenAIRE

    Izquierdo Perez, Ignacio; Hontecillas Guinart, Lluis

    2016-01-01

    The aim of this project is to model and validate an inductive system in order to be able to power wirelessly a sensor. The design of the inductive system must be small and light enough to fulfil the requirements of a nano-quadcopter, in which the system is going to be outfitted. Recent investigations about inductive systems added to the Energy Harvesting trend, predict a future based on wireless power. Thereby, the possibility to change the current "wire-dependence" of any device. At the begi...

  17. REDUCED ENERGY CONSUMPTION THROUGH PROJECTILE BASED EXCAVATION

    Energy Technology Data Exchange (ETDEWEB)

    Mark Machina

    2003-06-06

    The Projectile Based Excavation (ProjEX) program has as its goal, the reduction of energy required for production mining and secondary breakage through the use of a projectile based excavation system. It depends on the development of a low cost family of projectiles that will penetrate and break up different types of ore/rock and a low cost electric launch system. The electric launch system will eliminate the need for high cost propellant considered for similar concepts in the past. This document reports on the program findings through the first two phases. It presents projectile design and experiment data and the preliminary design for electric launch system. Advanced Power Technologies, Inc., now BAE SYSTEMS Advanced Technologies, Inc., was forced to withdraw from the program with the loss of one of our principal mining partners, however, the experiments conducted suggest that the approach is feasible and can be made cost effective.

  18. Prognosis in patients with atrial fibrillation and CHA2DS2-VASc Score = 0 in a community-based cohort study

    DEFF Research Database (Denmark)

    Taillandier, Sophie; Olesen, Jonas B; Clémenty, Nicolas;

    2012-01-01

    Patients with atrial fibrillation (AF) and a CHA(2) DS(2) -VASc score = 0 have a very low risk of stroke and current guidelines even recommend no antithrombotic therapy to these patients. We investigated the rate and risk of adverse events and the impact of antithrombotic management in a communit...

  19. Evaluation of low back pain using the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire for lumbar spinal disease in a multicenter study. Differences in scores based on age, sex, and type of disease

    International Nuclear Information System (INIS)

    The Japanese Orthopaedic Association (JOA) has investigated the JOA Back Pain Evaluation Questionnaire (JOABPEQ) to evaluate several aspects of low back pain in patients. The score includes five categories (25 items) selected from the Roland Morris Disability Questionnaire and Short Form 36, and a visual analogue scale. Japanese physicians have recently used these scores to evaluate back pain; however, the efficacy has not been fully explored in large-scale studies. In the current study, we used the JOABPEQ to evaluate lumbar spinal disease in 555 patients (with lumbar disc herniation, lumbar spinal stenosis, and lumbar disc degeneration/spondylosis) in multiple spine centers and compared the results based on age, sex, and type of disease. A total of 555 patients who had low back or leg pain were selected in 22 hospitals in Chiba Prefecture. Spine surgeons diagnosed their disease type based on symptoms, physical examination, radiography images, and magnetic resonance imaging. In all, 486 patients were diagnosed with spinal stenosis (239 patients), disc degeneration/spondylosis (143 patients), or disc herniation (104 patients). The other 69 patients were diagnosed with spondylolysis (16 patients) or other diseases (53 patients). The pain score in all patients was evaluated using the JOABPEQ (from 0 to 100, with 0 indicating the worst pain). The age of the patients was 56.1±13.3 years (mean±standard deviation (SD)); the age of patients in the disc herniation and disc degeneration/spondylosis group was significantly lower than that in the spinal stenosis group. The average JOABPEQ scores in all patients were, for low back pain, 47.1; lumbar function, 53.6; walking ability, 54.8; social life function, 48.7; and mental health, 48.3. The low back pain score in men was significantly worse than that in women. In contrast, the mental health score in women was significantly higher than that in men. The low back pain score in patients 65 years old were significantly lower

  20. Prepartum concentrate supplementation of a diet based on medium-quality grass silage: Effects on performance, health, fertility, metabolic function, and immune function of low body condition score cows.

    Science.gov (United States)

    Little, M W; O'Connell, N E; Welsh, M D; Barley, J; Meade, K G; Ferris, C P

    2016-09-01

    When cows with a "higher" body condition score (BCS) are oversupplied with energy during the dry period, postpartum energy balance is normally reduced, which can have a detrimental effect on immune competence and increase the infectious disease risk. However, within grassland-based systems higher yielding cows frequently have a low BCS at drying off. The effects on performance, health, and metabolic and immune functions of providing additional energy to cows with low BCS during the dry period is less certain. To address this uncertainty, 53 multiparous Holstein-Friesian cows (mean BCS of 2.5; 1-5 scale) were allocated to 1 of 2 treatments at dry-off: silage only or silage plus concentrates. Cows on the silage-only treatment were offered ad libitum access to medium-quality grass silage. Cows on the silage-plus-concentrate treatment were offered ad libitum access to a mixed ration comprising the same grass silage plus concentrates [in a 75:25 dry matter (DM) ratio], which provided a mean concentrate DM intake of 3.0kg/cow per day. Postpartum, cows were offered a common mixed ration comprising grass silage and concentrates (in a 40:60 DM ratio) for a 70-d period. Offering concentrates during the dry period increased DM intake, tended to increase energy balance, and increased body weight (BW) and BCS gain prepartum. Offering concentrates during the dry period increased BW and BCS loss postpartum and tended to increase milk fat percentage and serum nonesterified fatty acid concentration, but it did not affect postpartum DM intake, energy balance, and milk yield. Although the percentage of phagocytosis-positive neutrophils did not differ, neutrophils from cows on the silage-plus-concentrate treatment had higher phagocytic fluorescence intensity at 1 and 2 wk postpartum and higher phagocytic index at 1 wk postpartum. Serum haptoglobin concentrations and IFN-γ production by pokeweed mitogen stimulated whole blood culture were unaffected by treatment, although haptoglobin

  1. Evolution of Framingham cardiovascular risk score in HIV-infected patients initiating EFV- and LPV/r-based HAART in a Latin American cohort

    Directory of Open Access Journals (Sweden)

    Diego Cecchini

    2014-11-01

    Full Text Available Introduction: Epidemiological studies suggest that some antiretroviral drugs may contribute to increase cardiovascular risk in HIV-infected patients. However, data from Latin American countries are limited, as impact of HAART on cardiovascular risk remains understudied. In this context, we aimed to evaluate if 10-year Framingham Cardiovascular Risk Score (FCRS increases in patients following exposure to EFV- and LPV/r-based HAART in a Latin American cohort. Materials and Methods: Retrospective 48-week cohort study. We reviewed clinical charts of randomly selected samples of patients initiating (according to national guidelines EFV first-line HAART and LPV/r first- or second-line (but first PI-based HAART assisted at a reference HIV centre in Buenos Aires, Argentina (period 2004–2012. Each patient could only be included in one arm. FCRS was calculated according to National Institutes of Health risk assessment tool (http://cvdrisk.nhlbi.nih.gov/. Results: A total of 357 patients were included: 249 in EFV arm and 108 in LPV/r arm (80 as first line and 28 as second line, but first PI-based HAART. Baseline characteristics (median, interquartile range: age, 38 (33–45 years; male, 247 (69%; viral load, 98200 (20550–306000 copies/mL; CD4 T-cell count, 115 (60–175 cel/µL; total cholesterol, 159 (135–194 mg/dL; HDL: 39 (31–41 mg/dL; LDL: 94 (72–123 mg/dL; current smoker, 29%; on antihypertensive drugs: 14 (4%, diabetic: 4 (1%. Most frequent accompanying nucleoside reverse transcriptase inhibitors (NRTIs were 3TC (92% and zidovudine (AZT; 76%. Baseline FCRS was low, moderate and high for 93%, 7% and 0% of patients on EFV arm and 96.7%, 1.7% and 1.7% on LPV/r arm. On EFV arm, an increase in FCRS category (low to moderate or moderate to high was observed in 1 patient (0.9% at 24 weeks and 6 (5,6% at 48 weeks; 5 (4.7% decreased category. On LPV/r arm no one varied FCRS category at 24 weeks and 2 (3.4% increased from low to moderate at 48 weeks

  2. A new diagnostic score to detect osteoporosis in patients undergoing lumbar spine MRI

    International Nuclear Information System (INIS)

    Signal intensity of lumbar-spine at magnetic resonance imaging (MRI) correlates to bone mineral density (BMD). Our aim was to define a quantitative MRI-based score to detect osteoporosis on lumbar-spine MRI. After Ethics Committee approval, we selected female patients who underwent both lumbar-spine MRI and dual-energy X-ray absorptiometry (DXA) and a reference group of 131 healthy females (20-29 years) who underwent lumbar-spine MRI. We measured the intra-vertebral signal-to-noise ratio in L1-L4. We introduced an MRI-based score (M-score), on the model of T-score. M-score diagnostic performance in diagnosing osteoporosis was estimated against DXA using receiver operator characteristic (ROC) analysis. We included 226 patients (median age 65 years), 70 (31 %) being osteoporotic at DXA. MRI signal-to-noise ratio correlated to BMD (r = -0.677, P < 0.001). M-score negatively correlated to T-score (r = -0.682, P < 0.001). Setting a 90 %-specificity, an M-score threshold of 5.5 was found, distinguishing osteoporosis from non-osteoporosis (sensitivity 54 %; ROC AUC 0.844). Thirty-one (14 %) patients had a fragility fracture, with osteoporosis detected in 15 (48 %) according to M-score and eight (26 %) according to T-score (P = 0.016). M-score obtained on lumbar spine MRI is a quantitative method correlating with osteoporosis. Its diagnostic value remains to be demonstrated on a large prospective cohort of patients. (orig.)

  3. A new diagnostic score to detect osteoporosis in patients undergoing lumbar spine MRI

    Energy Technology Data Exchange (ETDEWEB)

    Bandirali, Michele; Messina, Carmelo [Universita degli Studi di Milano, Scuola di Specializzazione in Radiodiagnostica, Milano (Italy); Di Leo, Giovanni; Papini, Giacomo Davide Edoardo [IRCCS Policlinico San Donato, Radiology Unit, San Donato Milanese (Italy); Sconfienza, Luca Maria; Sardanelli, Francesco [IRCCS Policlinico San Donato, Radiology Unit, San Donato Milanese (Italy); Universita degli Studi di Milano, Dipartimento di Scienze Biomediche per la Salute, San Donato Milanese (Italy); Ulivieri, Fabio Massimo [IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Mineralometria Ossea Computerizzata e Ambulatorio Malattie Metabolismo Minerale e Osseo, Servizio di Medicina Nucleare, Milano (Italy)

    2015-10-15

    Signal intensity of lumbar-spine at magnetic resonance imaging (MRI) correlates to bone mineral density (BMD). Our aim was to define a quantitative MRI-based score to detect osteoporosis on lumbar-spine MRI. After Ethics Committee approval, we selected female patients who underwent both lumbar-spine MRI and dual-energy X-ray absorptiometry (DXA) and a reference group of 131 healthy females (20-29 years) who underwent lumbar-spine MRI. We measured the intra-vertebral signal-to-noise ratio in L1-L4. We introduced an MRI-based score (M-score), on the model of T-score. M-score diagnostic performance in diagnosing osteoporosis was estimated against DXA using receiver operator characteristic (ROC) analysis. We included 226 patients (median age 65 years), 70 (31 %) being osteoporotic at DXA. MRI signal-to-noise ratio correlated to BMD (r = -0.677, P < 0.001). M-score negatively correlated to T-score (r = -0.682, P < 0.001). Setting a 90 %-specificity, an M-score threshold of 5.5 was found, distinguishing osteoporosis from non-osteoporosis (sensitivity 54 %; ROC AUC 0.844). Thirty-one (14 %) patients had a fragility fracture, with osteoporosis detected in 15 (48 %) according to M-score and eight (26 %) according to T-score (P = 0.016). M-score obtained on lumbar spine MRI is a quantitative method correlating with osteoporosis. Its diagnostic value remains to be demonstrated on a large prospective cohort of patients. (orig.)

  4. Value of the energy data base

    Energy Technology Data Exchange (ETDEWEB)

    King, D.W.; Griffiths, J.M.; Roderer, N.K.; Wiederkehr, R.R.V.

    1982-03-31

    An assessment was made of the Energy Data Base (EDB) of the Department of Energy's Technical Information Center (TIC). As the major resource containing access information to the world's energy literature, EDB products and services are used extensively by energy researchers to identify journal articles, technical reports and other items of potential utility in their work. The approach taken to assessing value begins with the measurement of extent of use of the EDB. Apparent value is measured in terms of willingness to pay. Consequential value is measured in terms of effect - for searching, the cost of reading which results; and for reading, the savings which result from the application of the information obtained in reading. Resulting estimates of value reflect value to the searchers, the reader, and the reader's organization or funding source. A survey of the 60,000 scientists and eingineers funded by the DOE shows that annually they read about 7.1 million journal articles and 6.6 million technical reports. A wide range of savings values were reported for one-fourth of all article readings and three-fourths of all report readings. There was an average savings of $590 per reading of all articles; there was an average savings of $1280 for technical reports. The total annual savings attributable to reading by DOE-funded scientists and engineers is estimated to be about $13 billion. An investment of $5.3 billion in the generation of information and about $500 million in processing and using information yields a partial return of about $13 billion. Overall, this partial return on investment is about 2.2 to 1. In determining the value of EDB only those searches and readings directly attributable to it are included in the analysis. The values are $20 million to the searchers, $117 million to the readers and $3.6 billion to DOE.

  5. Using net energy output as the base to develop renewable energy

    International Nuclear Information System (INIS)

    In order to increase energy security, production of renewable energies has been highly promoted by governments around the world in recent years. The typical base of various policy instruments used for this purpose is gross energy output of renewable energy. However, we show that basing policy instruments on gross energy output will result in problems associated with energy waste, economic inefficiency, and negative environmental effects. We recommend using net energy output as the base to apply price or quantity measures because it is net energy output, not gross energy output, which contributes to energy security. The promotion of gross energy output does not guarantee a positive amount of net energy output. By basing policy instruments on net energy output, energy security can be enhanced and the above mentioned problems can be avoided.

  6. Using net energy output as the base to develop renewable energy

    Energy Technology Data Exchange (ETDEWEB)

    Shaw Daigee [Chung-Hua Institution for Economic Research, 75 Chang-Hsing St., Taipei, Taiwan 106 (China); Hung Mingfeng, E-mail: eureka@mail.tku.edu.t [Department of Industrial Economics, Tamkang University, Tamsui, Taipei County, Taiwan 251 (China); Lin Yihao [Chung-Hua Institution for Economic Research, 75 Chang-Hsing St., Taipei, Taiwan 106 (China)

    2010-11-15

    In order to increase energy security, production of renewable energies has been highly promoted by governments around the world in recent years. The typical base of various policy instruments used for this purpose is gross energy output of renewable energy. However, we show that basing policy instruments on gross energy output will result in problems associated with energy waste, economic inefficiency, and negative environmental effects. We recommend using net energy output as the base to apply price or quantity measures because it is net energy output, not gross energy output, which contributes to energy security. The promotion of gross energy output does not guarantee a positive amount of net energy output. By basing policy instruments on net energy output, energy security can be enhanced and the above mentioned problems can be avoided.

  7. Using net energy output as the base to develop renewable energy

    Energy Technology Data Exchange (ETDEWEB)

    Shaw, Daigee; Lin, Yi-Hao [Chung-Hua Institution for Economic Research, 75 Chang-Hsing St., Taipei, Taiwan 106 (China); Hung, Ming-Feng [Department of Industrial Economics, Tamkang University, Tamsui, Taipei County, Taiwan 251 (China)

    2010-11-15

    In order to increase energy security, production of renewable energies has been highly promoted by governments around the world in recent years. The typical base of various policy instruments used for this purpose is gross energy output of renewable energy. However, we show that basing policy instruments on gross energy output will result in problems associated with energy waste, economic inefficiency, and negative environmental effects. We recommend using net energy output as the base to apply price or quantity measures because it is net energy output, not gross energy output, which contributes to energy security. The promotion of gross energy output does not guarantee a positive amount of net energy output. By basing policy instruments on net energy output, energy security can be enhanced and the above mentioned problems can be avoided. (author)

  8. PBSA_E: A PBSA-Based Free Energy Estimator for Protein-Ligand Binding Affinity.

    Science.gov (United States)

    Liu, Xiao; Liu, Jinfeng; Zhu, Tong; Zhang, Lujia; He, Xiao; Zhang, John Z H

    2016-05-23

    Improving the accuracy of scoring functions for estimating protein-ligand binding affinity is of significant interest as well as practical utility in drug discovery. In this work, PBSA_E, a new free energy estimator based on the molecular mechanics/Poisson-Boltzmann surface area (MM/PBSA) descriptors, has been developed. This free energy estimator was optimized using high-quality experimental data from a training set consisting of 145 protein-ligand complexes. The method was validated on two separate test sets containing 121 and 130 complexes. Comparison of the binding affinities predicted using the present method with those obtained using three popular scoring functions, i.e., GlideXP, GlideSP, and SYBYL_F, demonstrated that the PBSA_E method is more accurate. This new energy estimator requires a MM/PBSA calculation of the protein-ligand binding energy for a single complex configuration, which is typically obtained by optimizing the crystal structure. The present study shows that PBSA_E has the potential to become a robust tool for more reliable estimation of protein-ligand binding affinity in structure-based drug design. PMID:27088302

  9. Fingermark evidence evaluation based on automated fingerprint identification system matching scores: the effect of different types of conditioning on likelihood ratios.

    Science.gov (United States)

    Alberink, Ivo; de Jongh, Arent; Rodriguez, Crystal

    2014-01-01

    In recent studies, the evidential value of the similarity of minutiae configurations of fingermarks and fingerprints, for example expressed by automated fingerprint identification systems (AFIS), is determined by likelihood ratios (LRs). The paper explores whether there is an effect on LRs if conditioning takes place on specified fingers, fingerprints, or fingermarks under competing hypotheses: In addition, an approach is explored where conditioning is asymmetric. Comparisons between fingerprints and simulated fingermarks with eight minutiae are performed to produce similarity score distributions for each type of conditioning, given a fixed AFIS matching algorithm. Both similarity scores and LRs are significantly different if the conditioning changes. Given a common-source scenario, "LRs" resulting from asymmetric conditioning are on average higher. The difference may reach a factor of 2000. As conditioning on a suspect's finger(print) is labor-intensive and requires a cooperating suspect, it is recommended to just condition on the number of minutiae in the fingermark. PMID:24180303

  10. CVLEACH: Coverage based energy efficient LEACH algorithm

    OpenAIRE

    Ankit Thakkar; Dr K Kotecha

    2012-01-01

    Designing a protocol stack for wireless sensor network (WSN)is a challenging task due to energy, computational and storageconstraints. Energy spent for communication between sensornodes dominates the energy spent for the computation [10].Multi-hop short range communication between wireless sensorsnodes is energy efficient compared to single-hop long rangecommunication. Hierarchical clustering is one of the possiblesolutions to save energy of wireless sensor nodes. Low-EnergyAdaptive Clusterin...

  11. Final Gleason Score Prediction Using Discriminant Analysis and Support Vector Machine Based on Preoperative Multiparametric MR Imaging of Prostate Cancer at 3T

    OpenAIRE

    Esen, Tarık; Çıtak-Er, Füsun; Vural, Metin; Onay, Aslıhan; Öztürk-Işık, Esin

    2014-01-01

    Objective. This study aimed at evaluating linear discriminant analysis (LDA) and support vector machine (SVM) classifiers for estimating final Gleason score preoperatively using multiparametric magnetic resonance imaging (mp-MRI) and clinical parameters. Materials and Methods. Thirty-three patients who underwent mp-MRI on a 3T clinical MR scanner and radical prostatectomy were enrolled in this study. The input features for classifiers were age, the presence of a palpable prostate abnormality,...

  12. Measuring self-concept of one’s own ability with experiment-based behaviour assessment: towards the construct validity of three scoring variants

    OpenAIRE

    Martina Frebort; MICHAELA M. WAGNER-MENGHIN

    2011-01-01

    Self-concept of one’s ability is an important construct influencing academic performance (Elliot & Dweck, 2005). The present study deals with the self-concept of one’s domain-specific prior knowledge in Psychology. Here, it is measured indirectly through WITE-Psychology (Frebort, unpublished), a knowledge test that measures Psychology student applicants’ Psychology knowledge. To measure self-concept of one’s domain-specific prior knowledge in Psychology, Wagner-Menghin’s (2004) scoring varian...

  13. Effect of a Physical Education-Based Stretching Programme on Sit-and-Reach Score and Its Posterior Reduction in Elementary Schoolchildren

    Science.gov (United States)

    Merino-Marban, Rafael; Mayorga-Vega, Daniel; Fernandez-Rodriguez, Emilio; Estrada, Francisco Vera; Viciana, Jesús

    2015-01-01

    The purpose of this study was to examine the effects of a 1-minute stretching programme and 5 weeks of detraining on sit-and-reach score among schoolchildren aged 5-6 years in a physical education setting. Forty-five schoolchildren 5-6 years old from two classes were clustered randomly assigned to an experimental group (n = 23) or a control group…

  14. EFFECT OF HELICOBACTER PYLORI ERADICATION ON HEPATIC STEATOSIS, NAFLD FIBROSIS SCORE AND HSENSI IN PATIENTS WITH NONALCOHOLIC STEATOHEPATITIS: a MR imaging-based pilot open-label study

    Directory of Open Access Journals (Sweden)

    Stergios A POLYZOS

    2014-09-01

    Full Text Available Context Limited clinical data suggest Helicobacter pylori (Hp infection may contribute to nonalcoholic fatty liver disease (NAFLD pathogenesis. Objectives The effect of Hp eradication on hepatic steatosis (magnetic resonance imaging, nonalcoholic fatty liver disease fibrosis score and HSENSI (Homocysteine, serum glutamic oxaloacetic transaminase, Erythrocyte sedimentation rate, nonalcoholic steatohepatitis Index in nonalcoholic steatohepatitis patients. Methods Thirteen adult patients with biopsy-proven nonalcoholic steatohepatitis, asymptomatic for gastrointestinal disease, underwent 13C urea breath test; Hp positive patients received eradication therapy until repeat test become negative. Hepatic fat fraction, standard biochemical tests and calculation of nonalcoholic fatty liver disease fibrosis score and HSENSI were performed at baseline and month 12. Results Hepatic fat fraction was similar for between and within group comparisons. Nonalcoholic fatty liver disease fibrosis score showed a non-significant trend towards decrease in Hp(+ [-0.34 (-1.39-0.29 at baseline and -0.24 (-0.99-0.71 at month 12; P = 0.116], whereas increase in Hp(- group [-0.38 (-1.72-0.11 and -0.56 (-1.43-0.46, respectively; P = 0.249]. HSENSI was significantly decreased only in Hp(+ group [1.0 (1.0-2.0 at baseline and 1.0 (0-1.0 at month 12; P = 0.048]. Conclusions Hp eradication had no long-term effect on hepatic steatosis, but showed a trend towards improvement in nonalcoholic fatty liver disease fibrosis score and HSENSI. These results warrant larger studies with paired biopsies.

  15. The evaluation of prescription dispensing scores of the pharmacy students before and after the problem-based “rational drug use” course: Results of the two years' experience

    Directory of Open Access Journals (Sweden)

    Hale Zerrin Toklu

    2013-09-01

    Full Text Available Pharmacists have a crucial role in promoting rational use of drugs. Therefore, pharmacy schools should prepare a realistic program that is competent with the changing role of the pharmacist. Pharmacy education should provide ability for critical thinking, improve problem-solving skills and decision making during pharmacotherapy. Problem-based pharmacotherapy teaching methods help pharmacy students gain the skill to implement theoretical knowledge into practice. The present study evaluates the efficacy of a problem based “rational drug use course” in the pharmacy curriculum of Near East University and reviews the results of this two year experience. An elective practical rational pharmacotherapy course was given in 2011 and 2012, to 3rd year pharmacy students at Near East University by a method based on simulated patients and evaluation of dispensing scores. A pretest was conducted to evaluate the baseline dispensing score by OSPE (objective structured practical examination and it was repeated at the end of the course (post-test. It was seen that the average dispensing score of group A (n=34 students was 34.26 ± 13.6, whereas it was 34.94 ± 11.6 for group B (n=17 in the pre-test (before the course. It increased almost twice to 62.18 ± 13.0 and 67.06 ± 15.6, respectively in Group A and B at the end of the semester (post-test. This improvement in the dispensing scores of the pharmacy students after the practical rational pharmacotherapy course were statistically significant (p<0.001. Thus, the unique OSPE score sheet/ checklist (that has been developed by Turkish Pharmacological Society seems user-friendly and useful.

  16. Dielectric Sensors Based on Electromagnetic Energy Tunneling

    Directory of Open Access Journals (Sweden)

    Omar Siddiqui

    2015-03-01

    Full Text Available We show that metallic wires embedded in narrow waveguide bends and channels demonstrate resonance behavior at specific frequencies. The electromagnetic energy at these resonances tunnels through the narrow waveguide channels with almost no propagation losses. Under the tunneling behavior, high-intensity electromagnetic fields are produced in the vicinity of the metallic wires. These intense field resonances can be exploited to build highly sensitive dielectric sensors. The sensor operation is explained with the help of full-wave simulations. A practical setup consisting of a 3D waveguide bend is presented to experimentally observe the tunneling phenomenon. The tunneling frequency is predicted by determining the input impedance minima through a variational formula based on the Green function of a probe-excited parallel plate waveguide.

  17. Dynamic TIMI Risk Score for STEMI

    OpenAIRE

    Amin, Sameer T.; Morrow, David A.; Braunwald, Eugene; Sloan, Sarah; Contant, Charles; Murphy, Sabina; Antman, Elliott M.

    2013-01-01

    Background Although there are multiple methods of risk stratification for ST‐elevation myocardial infarction (STEMI), this study presents a prospectively validated method for reclassification of patients based on in‐hospital events. A dynamic risk score provides an initial risk stratification and reassessment at discharge. Methods and Results The dynamic TIMI risk score for STEMI was derived in ExTRACT‐TIMI 25 and validated in TRITON‐TIMI 38. Baseline variables were from the original TIMI ris...

  18. Schooling in adolescence raises IQ scores

    OpenAIRE

    Brinch, Christian N.; Galloway, Taryn Ann

    2011-01-01

    Although some scholars maintain that education has little effect on intelligence quotient (IQ) scores, others claim that IQ scores are indeed malleable, primarily through intervention in early childhood. The causal effect of education on IQ at later ages is often difficult to uncover because analyses based on observational data are plagued by problems of reverse causation and self-selection into further education. We exploit a reform that increased compulsory schooling from 7 to 9 y in Norway...

  19. Fingerprinting of music scores

    Science.gov (United States)

    Irons, Jonathan; Schmucker, Martin

    2004-06-01

    Publishers of sheet music are generally reluctant in distributing their content via the Internet. Although online sheet music distribution's advantages are numerous the potential risk of Intellectual Property Rights (IPR) infringement, e.g. illegal online distributions, disables any innovation propensity. While active protection techniques only deter external risk factors, additional technology is necessary to adequately treat further risk factors. For several media types including music scores watermarking technology has been developed, which ebeds information in data by suitable data modifications. Furthermore, fingerprinting or perceptual hasing methods have been developed and are being applied especially for audio. These methods allow the identification of content without prior modifications. In this article we motivate the development of watermarking and fingerprinting technologies for sheet music. Outgoing from potential limitations of watermarking methods we explain why fingerprinting methods are important for sheet music and address potential applications. Finally we introduce a condept for fingerprinting of sheet music.

  20. A Scoring Method for Quantitative Assessment of Cardiovascular Health Status Based on Non-linear Parameters%一种基于非线性参数的心血管健康状况定量评测方法

    Institute of Scientific and Technical Information of China (English)

    李霞; 白净; 金勋; 任志英

    2007-01-01

    目的 研究定量评测心血管系统功能状况的方法.方法 首先记录运动实验的心电信号,经信号处理得到运动心率变异信号,然后从中提取近似熵,复杂度以及散点图中的长轴、短轴和面积等5个参数,采用判别分析对两组典型人群进行判别分类.结果 在判别分析基础上建立一个百分制评分体系,并根据得分区间划分为4个等级.为了验证该评分体系的有效性,对3组健康状况不同的人群进行了打分,包括60位中年高血压患者,50位老年者以及110位年轻的健康者.结论 3组人群的健康状况评测结果与实际情况相符合,说明所提出的方法可以对测试者的心血管健康状况进行有效地评测.%Objective To study a scoring method for assessing function status of cardiovascular system quantitatively. Methods First, exercise heart rate variability (EHRV) was obtained from the primary dynamic electrocardiogram (ECG) recorded during exercise testing. Then appropriate entropy, relative complexity, and other three parameters extracted from poincare dispersed-dot plot were extracted from the EHRV. Discriminant analysis was used to classify two extreme groups.Results Based on the values of two groups from the discriminant formula, a scoring formula was proposed and four ranks were divided according to different score domains. A novel scoring method was established. To validate the proposed scoring method, 60 middle-aged hypertensives, 50 elder subjects and 110 young healthy subjects were examined and scored. Conclusion Scores of 220 subjects are consistent with their real health status. The proposed scoring method reflects the status of the subject's cardiovascular system effectively.

  1. Flow based vs. demand based energy-water modelling

    Science.gov (United States)

    Rozos, Evangelos; Nikolopoulos, Dionysis; Efstratiadis, Andreas; Koukouvinos, Antonios; Makropoulos, Christos

    2015-04-01

    The water flow in hydro-power generation systems is often used downstream to cover other type of demands like irrigation and water supply. However, the typical case is that the energy demand (operation of hydro-power plant) and the water demand do not coincide. Furthermore, the water inflow into a reservoir is a stochastic process. Things become more complicated if renewable resources (wind-turbines or photovoltaic panels) are included into the system. For this reason, the assessment and optimization of the operation of hydro-power systems are challenging tasks that require computer modelling. This modelling should not only simulate the water budget of the reservoirs and the energy production/consumption (pumped-storage), but should also take into account the constraints imposed by the natural or artificial water network using a flow routing algorithm. HYDRONOMEAS, for example, uses an elegant mathematical approach (digraph) to calculate the flow in a water network based on: the demands (input timeseries), the water availability (simulated) and the capacity of the transmission components (properties of channels, rivers, pipes, etc.). The input timeseries of demand should be estimated by another model and linked to the corresponding network nodes. A model that could be used to estimate these timeseries is UWOT. UWOT is a bottom up urban water cycle model that simulates the generation, aggregation and routing of water demand signals. In this study, we explore the potentials of UWOT in simulating the operation of complex hydrosystems that include energy generation. The evident advantage of this approach is the use of a single model instead of one for estimation of demands and another for the system simulation. An application of UWOT in a large scale system is attempted in mainland Greece in an area extending over 130×170 km². The challenges, the peculiarities and the advantages of this approach are examined and critically discussed.

  2. Olympic Scoring of English Compositions

    Science.gov (United States)

    Follman, John; Panther, Edward

    1974-01-01

    Examines empirically the efficacy of utilizing Olympic diving and gymnastic scoring systems for grading graduate students' English compositions. Results indicated that such scoring rules do not produce ratings different in reliability or in level from conventional letter grades. (ED)

  3. THE EFFICIENCY OF TENNIS DOUBLES SCORING SYSTEMS

    Directory of Open Access Journals (Sweden)

    Geoff Pollard

    2010-09-01

    Full Text Available In this paper a family of scoring systems for tennis doubles for testing the hypothesis that pair A is better than pair B versus the alternative hypothesis that pair B is better than A, is established. This family or benchmark of scoring systems can be used as a benchmark against which the efficiency of any doubles scoring system can be assessed. Thus, the formula for the efficiency of any doubles scoring system is derived. As in tennis singles, one scoring system based on the play-the-loser structure is shown to be more efficient than the benchmark systems. An expression for the relative efficiency of two doubles scoring systems is derived. Thus, the relative efficiency of the various scoring systems presently used in doubles can be assessed. The methods of this paper can be extended to a match between two teams of 2, 4, 8, …doubles pairs, so that it is possible to establish a measure for the relative efficiency of the various systems used for tennis contests between teams of players.

  4. Customizing Scoring Functions for Docking

    OpenAIRE

    Pham, Tuan A.; Jain, Ajay N.

    2008-01-01

    Empirical scoring functions used in protein-ligand docking calculations are typically trained on a dataset of complexes with known affinities with the aim of generalizing across different docking applications. We report a novel method of scoring-function optimization that supports the use of additional information to constrain scoring function parameters, which can be used to focus a scoring function’s training towards a particular application, such as screening enrichment. The approach combi...

  5. The Effects of Using Different Procedures to Score Maze Measures

    Science.gov (United States)

    Pierce, Rebecca L.; McMaster, Kristen L.; Deno, Stanley L.

    2010-01-01

    The purpose of this study was to examine how different scoring procedures affect interpretation of maze curriculum-based measurements. Fall and spring data were collected from 199 students receiving supplemental reading instruction. Maze probes were scored first by counting all correct maze choices, followed by four scoring variations designed to…

  6. Hydrogen based energy storage for solar energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Vanhanen, J.; Hagstroem, M.; Lund, P. [Helsinki Univ. of Technology, Otaniemi (Finland). Advanced Energy Systems

    1998-10-01

    The main technical constraint in solar energy systems which operate around the year is the lack of suitable long-term energy storage. Conventional solutions to overcome the problem of seasonal storage in PV power systems are to use oversized batteries as a seasonal energy storage, or to use a diesel back-up generator. However, affordable lead-acid batteries are not very suitable for seasonal energy storage because of a high self-discharge rate and enhanced deterioration and divergence of the single cells during prolonged periods of low state of charge in times of low irradiation. These disadvantages can be avoided by a back-up system, e.g. a diesel generator, which car supply energy to the loads and charge the battery to the full state of charge to avoid the above mentioned disadvantages. Unfortunately, diesel generators have several disadvantages, e.g. poor starting reliability, frequent need for maintenance and noise

  7. Correlations between FDG PET glucose uptake-MRI gray matter volume scores and apolipoprotein E ε4 gene dose in cognitively normal adults: a cross-validation study using voxel-based multi-modal partial least squares

    OpenAIRE

    Chen, Kewei; Ayutyanont, Napatkamon; Langbaum, Jessica B. S.; Fleisher, Adam S.; Reschke, Cole; Lee, Wendy; Liu, Xiaofen; Alexander, Gene E; Bandy, Dan; Caselli, Richard J.; Reiman, Eric M

    2012-01-01

    We previously introduced a voxel-based, multi-modal application of the partial least square algorithm (MMPLS) to characterize the linkage between patterns in a person’s complementary complex datasets without the need to correct for multiple regional comparisons. Here we used it to demonstrate a strong correlation between MMPLS scores to characterize the linkage between the covarying patterns of fluorodeoxyglucose positron emission tomography (FDG PET) measurements of regional glucose metaboli...

  8. Evaluation of weigth gain, dry matter intake, body condition score and carcass yield of feedlot lambs of the Lacaune breed fed different energy levels in the concentrate

    Directory of Open Access Journals (Sweden)

    Anderson Elias Bianchi

    2012-12-01

    Full Text Available The dairy sheep industry has been growing in various regions of the country, and this production system allows the production of lambs for slaughter during the year, making it necessary to apply techniques for growing and fattening to ensure that they have a good development and provide housing quality to the consumer market. Therefore, the objective was to evaluate the influence on the supply of concentrate with different energy levels within the confines of Lacaune lambs. We used 27 lambs and steers with average initial weight 13.3 kg. The treatments were different energy levels in the diet: T1-concentrate with 65% TDN (total digestive nutrient, T2-70% TDN, and T3-75% TDN, both isoproteic with 17% CP (crude protein. The roughage used was Tifton 85 hay (Cynodon spp. We used a roughage concentrate 50:50. The experimental design was randomized blocks with three replications and three experimental units each. The evaluations were performed every 14 days and the animals were slaughtered after 106 days of confinement, with average weight of 28.61 kg, did not differ between treatments. The results were analyzed by MULTIV. The treatments did not differ for average daily gain (ADG, obtaining an ADG of 150 grams. You can visually verify a better body shape of animals receiving medium and higher levels of energy in relation to the treatment diet that has less energy. Regarding the dry matter intake (% body weight lambs from T2 (4.08 and T3 (4.03 had a higher consumption in relation to body weight compared with the T1 (3.84. The carcass did not differ between the treatments of which we obtained an average yield of 40.77% of hot carcass, cold carcass weight of 39.69%. The provision of different energy levels did not affect the productive performance of dairy sheep Lacaune breed, but the confinement is efficient in productive variables evaluated.

  9. Credit Scoring Modeling

    Directory of Open Access Journals (Sweden)

    Siana Halim

    2014-01-01

    Full Text Available It is generally easier to predict defaults accurately if a large data set (including defaults is available for estimating the prediction model. This puts not only small banks, which tend to have smaller data sets, at disadvantage. It can also pose a problem for large banks that began to collect their own historical data only recently, or banks that recently introduced a new rating system. We used a Bayesian methodology that enables banks with small data sets to improve their default probability. Another advantage of the Bayesian method is that it provides a natural way for dealing with structural differences between a bank’s internal data and additional, external data. In practice, the true scoring function may differ across the data sets, the small internal data set may contain information that is missing in the larger external data set, or the variables in the two data sets are not exactly the same but related. Bayesian method can handle such kind of problem.

  10. Evaluated body condition score (bcs in puerperal period

    Directory of Open Access Journals (Sweden)

    Ilir Dova

    2013-09-01

    Full Text Available BCS provides an important evaluation of the energy status of cows in puerperal period. This evaluation method provides a subjective indication of the fat cover on cows. To evaluate BCS is used a scoring point system based on the fat deposited in external part of the cow. In this study to evaluate BCS in cows in different farms we used 1 to 9 scoring system. The data shows different BCS classes between cows in different farms. All farms included in study shows that the BCS level is lower than the ideal BCS. This proves that all farms involved in the study have a level of feeding which is not optimal. In the period up to 2 months after calving is observed a gradual reduction of BCS in dairy cows.

  11. Comparison of BISAP Score with Ranson Score in Determining the Severity of Acute Pancreatitis

    International Nuclear Information System (INIS)

    Objective:To determine the accuracy of BISAPscore in finding out the frequency of severity and mortality in patients with acute pancreatitis by comparing it with Ranson score. Study Design: Crosse-sectional study. Place and Duration of Study: Department of Surgery, Pakistan Institute of Medical Sciences, Islamabad, from April to December 2010. Methodology: A total of 80 patients who presented in emergency with acute pancreatitis were included by consecutive non probability sampling technique. Cases of acute pancreatitis were classified as mild or severe based on the organ failure criteria and/or local complications according to the Atlanta Symposium. All patients were scored according to both Ranson score and BISAP score. Results: Out of 80 patients, 35 (44 percentage) were males and 45 (56 percentage) were females. The mean age was 46.89 ± 15.75 years. Twenty five patients (31.25 percentage) were classified as severe acute pancreatitis and 3 patients (3.75 percentage) had evidence of pancreatic necrosis on CT scan. The duration of hospital stay was 1 - 54 days with a mean of 13.12 ± 12.83 days and mortality rate was 5 percentage. The number of patients with a BISAP score of =3 was 15 and Ranson score =3 was 25. The observed incidence of severe disease stratified by the BISAP score has (p greater than 0.001) and by Ranson score has (p greater than 0.001). In regards to mortality, patients having BISAP score =3 has p=0.003, while patients having Ranson score =3 has p=0.002, both are statistically significant. Conclusion:The newly proposed BISAPscore is a simple and accurate tool for severity stratification and is equally effective in finding out frequency of severity and in turns mortality in patients with acute pancreatitis as Ranson score. (author)

  12. A Web Based Puzzle for Energy Sources

    Directory of Open Access Journals (Sweden)

    Nilgun SECKEN

    2006-07-01

    Full Text Available At present many countries in the world consume too much fossil fuels such as petroleum, natural gas and coal to meet their energy needs. These fossil fuels are not renewable; their sources are limited and reducing gradually. More importantly they have been becoming more expensive day by day and their damage to the environment has been increasing. In spite of it, renewable energy sources are renewed and never run out. In addition there are many benefits of renewable energy. In this study a puzzle is prepared for primary-school students aiming at teaching of energy sources as a supplementary source. In the mean time, the puzzle we prepared reveals the advantages and disadvantages of renewable and fossil energy sources. Here, the student’s aim is to complete the puzzle by answering the questions respectively. .

  13. Prognostic value of perfusion defect volume at dual energy CTA in patients with pulmonary embolism: Correlation with CTA obstruction scores, CT parameters of right ventricular dysfunction and adverse clinical outcome

    Energy Technology Data Exchange (ETDEWEB)

    Apfaltrer, Paul, E-mail: paul.apfaltrer@medma.uni-heidelberg.de [Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Bachmann, Valentin, E-mail: valentin.bachmann@googl.com [Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Meyer, Mathias, E-mail: mr.meyer.mathias@gmail.com [Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Henzler, Thomas, E-mail: Thomas.Henzler@umm.de [Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Barraza, John M., E-mail: barraza@musc.edu [Department of Radiology and Radiological Science, Medical University of South Carolina, PO Box 250322, 169 Ashley Avenue, Charleston, SC 29425 (United States); Gruettner, Joachim, E-mail: joachim.gruettner@umm.de [1st Department of Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Walter, Thomas, E-mail: Thomas.Walter2@umm.de [1st Department of Medicine, University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim (Germany); Schoepf, U. Joseph, E-mail: schoepf@musc.edu [Department of Radiology and Radiological Science, Medical University of South Carolina, PO Box 250322, 169 Ashley Avenue, Charleston, SC 29425 (United States); and others

    2012-11-15

    Purpose: To investigate the prognostic value of perfusion defect volume (PDvol) at dual-energy-CT-angiography (DE-CTA) in patients with acute pulmonary embolism (PE) by correlating PDvol with CTA-obstruction-scores (OS), CT parameters of right-ventricular-dysfunction (RVD), and adverse-clinical-outcome. Materials and methods: DE-CTA of 60 patients (mean age: 65 {+-} 14.4 years) with PE were analyzed. Iodine maps were generated, and normalized PDvol - defined as volume of perfusion defects/total lung volume - was quantified. Furthermore, established prognostic parameters (Qanadli and Mastora-OS, and CT parameters of RVD) were obtained. CT parameters of RVD - namely the right ventricle/left ventricle (RV/LV) diameter ratio measured on transverse sections (RV/LVtrans), four-chamber views (RV/LV4ch), and RV/LV volume ratios (RV/LVvol) - were assessed. PDvol was correlated with OS, CT parameters of RVD and adverse clinical outcome (defined as the need for intensive care treatment or death). Results: 10 of 60 patients with PE experienced adverse clinical outcome. Patients with adverse clinical outcome showed significantly higher PDvol (35 {+-} 11% vs. 23 {+-} 10%, p = 0.002), RV/LV ratios (RV/LV4ch 1.46 {+-} 0.32 vs. 1.18 {+-} 0.26, p = 0.005; RV/LVvol 2.25 {+-} 1.33 vs. 1.19 {+-} 0.56, p = 0.002) and higher Mastora global scores (52 vs. 13, p = 0.02) compared to those without adverse clinical outcome. A weak correlation was observed between PDvol and the Mastora global score (r = 0.5; p = 0.0003), as well as between PDvol and RV/LV4Ch (r = 0.432, p = 0.0006). No correlation was found between PDvol and the Qanadli score or the remainder of the RVD-CT parameters. Conclusion: The extent of perfusion defects as assessed by DE-CTA correlates with adverse clinical outcome in patients with PE. Therefore, volumetric quantification of perfusion defects at DE-CTA allows the identification of low-risk patients who do not require intensified monitoring and treatment.

  14. A filter enhanced sampling and combinatorial scoring study for protein docking in CAPRI.

    Science.gov (United States)

    Gong, Xin Qi; Chang, Shan; Zhang, Qing Hua; Li, Chun Hua; Shen, Long Zhu; Ma, Xiao Hui; Wang, Ming Hui; Liu, Bin; He, Hong Qiu; Chen, Wei Zu; Wang, Cun Xin

    2007-12-01

    Protein-protein docking is usually exploited with a two-step strategy, i.e., conformational sampling and decoy scoring. In this work, a new filter enhanced sampling scheme was proposed and added into the RosettaDock algorithm to improve the conformational sampling efficiency. The filter term is based on the statistical result that backbone hydrogen bonds in the native protein structures are wrapped by more than nine hydrophobic groups to shield them from attacks of water molecules (Fernandez and Scheraga, Proc Natl Acad Sci USA 2003;100:113-118). A combinatorial scoring function, ComScore, specially designed for the other-type protein-protein complexes was also adopted to select the near native docked modes. ComScore was composed of the atomic contact energy, van der Waals, and electrostatic interaction energies, and the weight of each item was fit through the multiple linear regression approach. To analyze our docking results, the filter enhanced sampling scheme was applied to targets T12, T20, and T21 after the CAPRI blind test, and improvements were obtained. The ligand least root mean square deviations (L_rmsds) were reduced and the hit numbers were increased. ComScore was used in the scoring test for CAPRI rounds 9-12 with good success in rounds 9 and 11. PMID:17803223

  15. Making it possible to measure knowledge, experience and intuition in diagnosing lung injury severity: a fuzzy logic vision based on the Murray score

    Directory of Open Access Journals (Sweden)

    De Vito Eduardo L

    2010-11-01

    Full Text Available Abstract Background Murray score is the result of an equation that gives all its variables the same linear contribution and weight and makes use of consented cut-offs. Everyday physicians' vocabulary is full of terms (adjectives like: little, small, low, high, etc. that they handle in an intuitive and not always linear way to make therapeutic decisions. The purpose of this paper is to develop a fuzzy logic (FL vision of Murray's score variables to enable the measurement of physicians' knowledge, experience and intuition in diagnosing lung injury and test if they followed Murray's equation predictions. Methods For a prospective survey carried out among a team of professionals (aged 29 to 53 in a University Hospital Intensive Care Unit, twelve physicians filled in two questionnaires. In the first one they had to define the ranks which should be categorized as normal, moderate and severe for three of four Murray variables. In another questionnaire, which represented all probable combinations of those categories, they had to tick the pulmonary condition as: no injury, mild, moderate, and ARDS. This procedure gave rise to a Fuzzy Inference System designed to provide the degree of severity as sensed by the group. Results The survey showed fuzzy frontiers for the categories and fuzzy diagnosis. In all, 45% of the hypothetical patients (n 18,013 were equally diagnosed by the survey and Murray's equation, whereas another 51% was overestimated in one level by the survey. Physicians agreed with 96.5% of ARDS cases according to Murray's test but only 11.6% of its mild cases were equally diagnosed by the survey. Nonlinearity of the survey reasoning (high relevance to gas exchange and chest film was apparent. Conclusions The contiguous categories of the variables confirm the existence of fuzzy frontiers. An overestimation was found in the surveyed group's interpretation of severity. This overestimation was mainly due to the different weight assigned to PO2/Fi

  16. Wind Energy Conversion Based on Matrix Converter

    OpenAIRE

    Mutharasan Anburaj; Rameshkumar T; Ajitha A

    2014-01-01

    In recent years renewable sources such as solar, wave and wind are used for the generation of electricity. Wind is one of the major renewable sources. The amount of energy from a Wind Energy Conversion System (WECS) depends not only on the wind at the site, but also on the control strategy used for the WECS. In assistance to get the appropriate wind energy from the conversion system, wind turbine generator will be run in variable speed mode. The variable speed capability is achieved through t...

  17. A Web Based Puzzle for Energy Sources

    OpenAIRE

    Nilgun SECKEN

    2006-01-01

    At present many countries in the world consume too much fossil fuels such as petroleum, natural gas and coal to meet their energy needs. These fossil fuels are not renewable; their sources are limited and reducing gradually. More importantly they have been becoming more expensive day by day and their damage to the environment has been increasing. In spite of it, renewable energy sources are renewed and never run out. In addition there are many benefits of renewable energy. In this study a puz...

  18. Energy balance of individual cows can be estimated in real-time on-farm using only frequent liveweight measures even in the absence of body condition score

    DEFF Research Database (Denmark)

    Thorup, Vivi Mørkøre; Højsgaard, Søren; Weisbjerg, Martin Riis;

    2013-01-01

    holds the advantage of not requiring measurements of feed intake, which are difficult to obtain in practice. The present study aimed first to investigate whether the EBbody method can be simplified by basing EBbody on BW measurements alone, that is, removing the need for BCS measurements, and second to...... developed for breeds and parities. These standard body protein change functions allow EBbody to be estimated from frequent BW measurements alone, that is, in the absence of BCS measurements. Differences in EBbody levels before and after changes in concentrate intake were calculated to test the real...

  19. Energy Based Acoustic Measurement Senors Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This research focuses on fully developing energy density sensors that will yield a significant benefit both for measurements of interest to NASA, as well as for...

  20. Hydrogen based global renewable energy network

    Energy Technology Data Exchange (ETDEWEB)

    Akai, Makoto [Mechanical Engineering Laboratory, AIST, MITI, Namiki, Tsukuba (Japan)

    1993-12-31

    In the last quarter of this century, global environmental problem has emerged as a major scientific, political and social issue. Specific Problems include: depletion of ozone layer by chlorofluorocarbons (CFCs), acid rain, destruction of tropical forests and desertification, pollution of the sea and global wanning due to the greenhouse effect by carbon dioxide and others. Among these problems, particular attention of the world has been focused on the global warming because it has direct linkage to energy consumption which our economic development depends on so far. On the other hand, the future program of The Sunshine Project for alternative energy technology R&D, The Moonlight Project for energy conservation technology R&D, and The Global Environmental Technology Program for environmental problem mitigating technology R&D which are Japan`s national projects being promoted by their Agency of Industrial Science and Technology (AIST) in the Ministry of International Trade and Industry have been reexamined in view of recent changes in the situations surrounding new energy technology. In this regard, The New Sunshine Program will be established by integrating these three activities to accelerate R&D in the field of energy and environmental technologies. In the reexamination, additional stress has been laid on the contribution to solving global environmental problem through development of clean renewable energies which constitute a major part of the {open_quotes}New Earth 21{close_quotes}, a comprehensive, long-term and international cooperative program proposed by MITI. The present paper discusses the results of feasibility study on hydrogen energy system leading to the concept of WE-NET following a brief summary on R&D status on solar and wind energy in Japan.

  1. The Machine Scoring of Writing

    Science.gov (United States)

    McCurry, Doug

    2010-01-01

    This article provides an introduction to the kind of computer software that is used to score student writing in some high stakes testing programs, and that is being promoted as a teaching and learning tool to schools. It sketches the state of play with machines for the scoring of writing, and describes how these machines work and what they do.…

  2. Interpreting Linked Psychomotor Performance Scores

    Science.gov (United States)

    Looney, Marilyn A.

    2013-01-01

    Given that equating/linking applications are now appearing in kinesiology literature, this article provides an overview of the different types of linked test scores: equated, concordant, and predicted. It also addresses the different types of evidence required to determine whether the scores from two different field tests (measuring the same…

  3. An agent-based model for energy service companies

    International Nuclear Information System (INIS)

    Highlights: • An agent-based model for household energy efficiency upgrades is considered. • Energy service companies provide an alternative to traditional utility providers. • Household self-financing is a limiting factor to widespread efficiency upgrading. • Longer term service contracts can lead to reduced household energy costs. • Future energy price increases enable service providers to retain their customer base. - Abstract: The residential housing sector is a major consumer of energy accounting for approximately one third of carbon emissions in the United Kingdom. Achieving a sustainable, low-carbon infrastructure necessitates a reduced and more efficient use of domestic energy supplies. Energy service companies offer an alternative to traditional providers, which supply a single utility product to satisfy the unconstrained demand of end users, and have been identified as a potentially important actor in sustainable future economies. An agent-based model is developed to examine the potential of energy service companies to contribute to the large scale upgrading of household energy efficiency, which would ultimately lead to a more sustainable and secure energy infrastructure. The migration of households towards energy service companies is described by an attractiveness array, through which potential customers can evaluate the future benefits, in terms of household energy costs, of changing provider. It is shown that self-financing is a limiting factor to the widespread upgrading of residential energy efficiency. Greater reductions in household energy costs could be achieved by committing to longer term contracts, allowing upgrade costs to be distributed over greater time intervals. A steadily increasing cost of future energy usage lends an element of stability to the market, with energy service companies displaying the ability to retain customers on contract expiration. The model highlights how a greater focus on the provision of energy services, as

  4. MEMS-based thick film PZT vibrational energy harvester

    DEFF Research Database (Denmark)

    Lei, Anders; Xu, Ruichao; Thyssen, Anders;

    2011-01-01

    We present a MEMS-based unimorph silicon/PZT thick film vibrational energy harvester with an integrated proof mass. We have developed a process that allows fabrication of high performance silicon based energy harvesters with a yield higher than 90%. The process comprises a KOH etch using a...

  5. Discrepancy between coronary artery calcium score and HeartScore in middle-aged Danes

    DEFF Research Database (Denmark)

    Diederichsen, Axel Cosmus Pyndt; Sand, Niels Peter; Nørgaard, Bjarne;

    2012-01-01

    Background: Coronary artery calcification (CAC) is an independent and incremental risk marker. This marker has previously not been compared to the HeartScore risk model. Design: A random sample of 1825 citizens (men and women, 50 or 60 years of age) was invited for screening. Methods: Using the...... HeartScore model, the 10-year risk of fatal cardiovascular events based on gender, age, smoking, systolic blood pressure, and total cholesterol was estimated. A low risk was defined as...

  6. Score, Pseudo-Score and Residual Diagnostics for Spatial Point Process Models

    OpenAIRE

    Baddeley, Adrian; Rubak, Ege; Møller, Jesper

    2012-01-01

    We develop new tools for formal inference and informal model validation in the analysis of spatial point pattern data. The score test is generalized to a "pseudo-score" test derived from Besag's pseudo-likelihood, and to a class of diagnostics based on point process residuals. The results lend theoretical support to the established practice of using functional summary statistics, such as Ripley's $K$-function, when testing for complete spatial randomness; and they provide new tools such as th...

  7. 冷链物流采购第一评分密封招投标研究%Procurement of Cold-Chain Logistics Based on the First-Score Sealed Bidding

    Institute of Scientific and Technical Information of China (English)

    周乐欣; 王先甲; 吕凡

    2012-01-01

    allocation and payment functions are based on the composite score auction rather than price principle. The purchaser of logistics services chooses one multiple logistics service provider to reach agreement via the design of auction rules.Third, the logistics value of many products is very sensitive to the degree of realization of a number of quality indicators. This paper adopts the multi-attribute auction theory to design an integrated score auction model. An optimal strategy and a score function are proposed based on the cost and utility functions of the bidder.In summary, suppliers of cold-chain logistics have different supply cost and service quality because of their difference in management ability, technical ability, and operational capacity. According to the competitive bidding of logistics service providers, our proposed auction mechanisms can help achieve efficient allocation of logistics resources based on an enterprise's supply capacity.%针对食品冷冻、冷藏的冷链物流是一种特殊物流,食品安全和品质是其首要目标,同时还要考虑到及时性、运营成本等属性,所以冷链物流采购要考虑的是一个多目标问题.为采用招投标制度构建高效现代的物流采购市场,设计专门的招投标规则来对相应的物流供应商进行遴选有着非常的必要性.本文将多目标置于采购方的评分函数中,通过设计第一评分密封招投标规则来突破只对价格的考虑,对推动冷链流的高效采购和行业发展具有现实意义.

  8. Market-Based Mechanisms to Promote Renewable Energy in Asia

    OpenAIRE

    Venkatachalam ANBUMOZHI; Alex BOWEN; Puthusserikunnel Devasia JOSE

    2015-01-01

    Market-based instruments such as Renewable Energy Certificate (REC) are increasingly favoured as an alternative to command-and-control legislation to increase the uptake of renewable energy. Focusing on the renewable energy industry and policy situation in Asia, this paper analysed the strengths and weaknesses of market-based approaches in the long-term interest of developing Asia. It found that approaches such as REC are disadvantaged by a lack of both market acceptance and a strong institut...

  9. Smart and Green Energy (SAGE) for Base Camps Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Engels, Matthias; Boyd, Paul A.; Koehler, Theresa M.; Goel, Supriya; Sisk, Daniel R.; Hatley, Darrel D.; Mendon, Vrushali V.; Hail, John C.

    2014-02-11

    The U.S. Army Logistics Innovation Agency’s (LIA’s) Smart and Green Energy (SAGE) for Base Camps project was to investigate how base camps’ fuel consumption can be reduced by 30% to 60% using commercial off-the-shelf (COTS) technologies for power generation, renewables, and energy efficient building systems. Field tests and calibrated energy models successfully demonstrated that the fuel reductions are achievable.

  10. Electromagnetic ferrofluid-based energy harvester

    Science.gov (United States)

    Bibo, A.; Masana, R.; King, A.; Li, G.; Daqaq, M. F.

    2012-06-01

    This Letter investigates the use of ferrofluids for vibratory energy harvesting. In particular, an electromagnetic micro-power generator which utilizes the sloshing of a ferrofluid column in a seismically-excited tank is proposed to transform mechanical motions directly into electricity. Unlike traditional electromagnetic generators that implement a solid magnet, ferrofluids can easily conform to different shapes and respond to very small acceleration levels offering an untapped opportunity to design scalable energy harvesters. The feasibility of the proposed concept is demonstrated and its efficacy is discussed through several experimental studies.

  11. Landfill energy complex based on the renewable energy installations

    Science.gov (United States)

    Gilmanshin, Iskander; Kashapov, Nail; Gilmanshina, Suriya; Galeeva, Asiya

    2016-06-01

    The article presents the analysis of standard approaches to degassing of landfills. The need of comprehensive work on the degassing of the landfill body is identified. The author's task decomposition of the landfill degassing is formulated. The analysis of existing methods of work on degassing of landfills is presented. The author's approach is including implements of series of parallel studies in the framework of achieving a common goal to reduce the anthropogenic pressure on the ecosystem of the region due to the need for disposal of solid waste. An action plan for the development of the target problem-oriented management techniques of the landfill with the following development of the effective energy complex is formulated.

  12. A Web Based Puzzle for Energy Sources

    Science.gov (United States)

    Secken, Nilgun

    2006-01-01

    At present many countries in the world consume too much fossil fuels such as petroleum, natural gas and coal to meet their energy needs. These fossil fuels are not renewable; their sources are limited and reducing gradually. More importantly they have been becoming more expensive day by day and their damage to the environment has been increasing.…

  13. Serbian energy development based on lignite production

    International Nuclear Information System (INIS)

    Lignite, as an energy resource, is a mainstay of electricity generation in the Republic of Serbia. Installed capacity of lignite power plants represents 68% of the total installed capacity of Electric Power Industry of Serbia, the only company in Serbia, which manages electricity generation. In the future, with the increase in demand for electricity, both in Serbia and in Europe, we should expect more extensive and effective utilization of lignite as the main energy potential. In addition, due to increased emissions of CO2, NOX and other pollutants, the Republic of Serbia must accelerate the implementation of flexible mechanisms of Kyoto Protocol and the guidelines set by the European Union. Lignite in the future will retain its existential importance in the electricity generation in the Republic of Serbia. - Research highlights: → Lignite will retain its existential importance in the electricity generation in Serbia. → Energy politics after 2015 will require new and much larger investments in new lignite mines. → Serbia can expect over 7000 MW of installed power from lignite fired energy capacity.

  14. DEVELOPMENT OF FUEL AND ENERGY COMPLEX OF KRASNODAR REGION BASED ON INNOVATIVE ENERGY CONSERVATION AND ENERGY EFFICIENCY TECHNOLOGIES

    OpenAIRE

    Koshcheev Stanislav Viktorovich; Kuchenko Sergey Sergeevich

    2012-01-01

    Possibilities of solar collectors’ utilization in Krasnodar region as one of advanced direction of regions’ fuel and energy complex based on modern projects in energy conservation, energy efficiency and renewables’ technologies were reviewed in the article. Prospects of solar collectors’ utilization in Krasnodar region as alternative «green» energy source were presented. Modern science concepts of as alternative «green» energy source were presented, results of the research us of hospitality i...

  15. Promoting Behavior-Based Energy Efficiency in Military Housing

    Energy Technology Data Exchange (ETDEWEB)

    AH McMakin; EL Malone; RE Lundgren

    1999-09-07

    The U.S. Department of Energy's Federal Energy Management Program (FEMP) helps agencies reduce the cost of doing business through energy efficiency, water conservation, and the use of solar and other renewable energy. As a large energy user, the U.S. military has been one of the government sectors of focus. Several military installations have shown substantial energy savings in past years. Most of these efficiency projects, however, have focused primarily on physical upgrades, technologies, and purchasing habits. Furthermost projects have focused on administrative and operational areas of energy use. Military residential housing, in particular, has received little formal attention for energy efficiency involving behaviors of the residents themselves. Behavior-based change is a challenging, but potentially fruitful area for energy conservation programs. However, behavioral change involves links with values, social networks and organizations, and new ways of thinking about living patterns. This handbook attempts to fill a gap by offering guidance for promoting such efforts.

  16. Development of MEMS based pyroelectric thermal energy harvesters

    Science.gov (United States)

    Hunter, Scott R.; Lavrik, Nickolay V.; Bannuru, Thirumalesh; Mostafa, Salwa; Rajic, Slo; Datskos, Panos G.

    2011-06-01

    The efficient conversion of waste thermal energy into electrical energy is of considerable interest due to the huge sources of low-grade thermal energy available in technologically advanced societies. Our group at the Oak Ridge National Laboratory (ORNL) is developing a new type of high efficiency thermal waste heat energy converter that can be used to actively cool electronic devices, concentrated photovoltaic solar cells, computers and large waste heat producing systems, while generating electricity that can be used to power remote monitoring sensor systems, or recycled to provide electrical power. The energy harvester is a temperature cycled pyroelectric thermal-to-electrical energy harvester that can be used to generate electrical energy from thermal waste streams with temperature gradients of only a few degrees. The approach uses a resonantly driven pyroelectric capacitive bimorph cantilever structure that potentially has energy conversion efficiencies several times those of any previously demonstrated pyroelectric or thermoelectric thermal energy harvesters. The goals of this effort are to demonstrate the feasibility of fabricating high conversion efficiency MEMS based pyroelectric energy converters that can be fabricated into scalable arrays using well known microscale fabrication techniques and materials. These fabrication efforts are supported by detailed modeling studies of the pyroelectric energy converter structures to demonstrate the energy conversion efficiencies and electrical energy generation capabilities of these energy converters. This paper reports on the modeling, fabrication and testing of test structures and single element devices that demonstrate the potential of this technology for the development of high efficiency thermal-to-electrical energy harvesters.

  17. 基于改进图半监督学习的个人信用评估方法%Personal Credit Scoring Method Using Improved Graph Based Semi-Supervised Learning

    Institute of Scientific and Technical Information of China (English)

    张燕; 张晨光; 张夏欢

    2012-01-01

    Labeled instances are expensive to collect for personal credit scoring. However, unlabeled data are often relatively easy to obtain. Aiming at this problem and the ubiquitous asymmetry of credit datasets, this paper proposes a personal credit scoring model based on improved graph based semi-supervised learning method. Because the model adopts semi-supervised technology, it can learn from abundant unlabeled instances to avoid the decreasing of generalization ability which is induced by the relative lack of labeled data. Furthermore, by improving graph based semi-supervised learning technology with normalization and modification of decision boundary on its iterative results, the scoring model effectively reduces the bad impact of asymmetric dataset. Experiments on three UCI credit approval datasets show that the new scoring model can provide significantly better results than support vector machines and the unimproved method.%针对个人信用评估中未标号数据获取容易而已标号数据获取相对困难,以及普遍存在的数据不对称问题,提出了基于改进图半监督学习技术的个人信用评估模型.该模型采用了半监督学习技术,一方面能从大量的未标号数据中学习,避免了个人信用评估中已标号数据相对缺乏造成的泛化能力下降问题;另一方面,通过改进图半监督学习技术,对图半监督迭代结果进行归一化及修改决策边界,有效减小了数据不对称的影响.在UCI的三个信用审核数据集上的评测结果表明,该模型具有明显优于支持向量机和改进前方法的评估效果.

  18. Wind Energy Conversion Based on Matrix Converter

    Directory of Open Access Journals (Sweden)

    Mutharasan Anburaj

    2014-07-01

    Full Text Available In recent years renewable sources such as solar, wave and wind are used for the generation of electricity. Wind is one of the major renewable sources. The amount of energy from a Wind Energy Conversion System (WECS depends not only on the wind at the site, but also on the control strategy used for the WECS. In assistance to get the appropriate wind energy from the conversion system, wind turbine generator will be run in variable speed mode. The variable speed capability is achieved through the use of an advanced power electronic converter. Fixed speed wind turbines and induction generators are often used in wind farms. But the limitations of such generators are low efficiency and poor power quality which necessitates the variable speed wind turbine generators such as Doubly Fed Induction Generator (DFIG and Permanent Magnet Synchronous Generator (PMSG. A high-performance configuration can be obtained by using Scherbius drive composed of a DFIG and a converter in combination AC-DC-AC connect between stator & rotor points for providing the required variable speed operation

  19. National report card on energy efficiency : 6. annual report card on government activities based on performance of provinces between January 1 2005 to December 31 2005

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-11-15

    The sixth annual report card issued by the Canadian Energy Efficiency Alliance was presented. The report highlighted the progress and inaction of the federal government and provinces to reduce energy demand and consumption in 2005. Grades were based on the performance of jurisdictions between January 1 2005 and December 31 2005. Scoring for each of the 14 Canadian jurisdictions was based on 12 parameters which included the jurisdiction's supporting activities in energy efficiency and public outreach; the existence of public-private partnerships to support energy efficiency; the existence and responsiveness to energy efficiency issues in key legislation; and regulation of the energy market. The report indicated that the federal government's high score reflected a strong commitment towards supporting energy efficiency across the country for 2005. Ontario has supported energy efficiency with major new funding for conservation and demand management (CDM) programs in the electricity sector. Alberta's support for energy efficiency activities was disappointing, particularly when seen in context with the province's high contribution to greenhouse gases (GHGs) in Canada. Manitoba demonstrated success in all energy efficiency initiatives, which was attributed to Manitoba Hydro's excellent job in promoting and supporting energy efficiency. It was concluded that while there is greater need for program reporting and evaluation strategies in several jurisdictions, most jurisdictions have energy efficiency programs in place, as well as support codes and standards. 1 tab.

  20. Management of a power system based on renewable energy

    Directory of Open Access Journals (Sweden)

    Ronay Karoly

    2012-06-01

    Full Text Available This article main purpose is to highlight the main advantage of the hardware and software implementation for an energy management system based on renewable energy sources. By using implemented and dedicated hardware and software the evolution of energy production and consumption can be monitored. The advantages of such system are highlighted by the results obtained from experimental simulations. An experimental model for the power system based on renewable energy sources was implemented, where the actual status of the system in different situations when the equipments change their own statuses can be shown.

  1. Discrimination ability of the Energy score

    DEFF Research Database (Denmark)

    Pinson, Pierre; Tastu, Julija

    appealing since being proper, we show that its discrimination ability may be limited when focusing on the dependence structure of multivariate probabilistic forecasts. For the case of multivariate Gaussian process, a theoretical upper for such discrimination ability is derived and discussed. This limited...... discrimination ability may eventually get compromised by computational and sampling issues, as dimension increases....

  2. Energy concepts for self-supplying communities based on local and renewable energy sources

    DEFF Research Database (Denmark)

    Petersen, Jens-Phillip

    2016-01-01

    responsible entities for physical planning, can hold a key role in transforming energy systems towards carbon-neutrality, based on renewable energies. The implementation should be approached at community scale, which has advantages compared to only focusing on buildings or cities. But community energy...... settings. The current case study presents a community energy concept for the inner-city of Elmshorn. By estimating the energy demand, consideration of local energy saving potentials, and available energy potentials within the community, it was possible to develop several energy system variants that...... planning can be a complex and time-consuming process. Many municipalities hesitate to initiate such a process, because of missing guidelines and uncertainty about possible energy potentials. Case studies help to understand applied methodologies and could show available energy potentials in different local...

  3. Sea wave energy based in nanotechnology

    Energy Technology Data Exchange (ETDEWEB)

    Duque, Carlos

    2010-09-15

    Application on which it turns east document is the recovery of the energy of the sea waves turning it into electricity by means of the combination of nano-piezoelectric and condensing, the system would be seen like a compound floating fabric of million piezoelectric crystals that turn the oscillating movement of the sea into micro-electrical signals that they are added and they left by means cables to the surface where electronics devices classified to the load of condensers, from the electricity is confined and later is invested and synchronize itself with the great national mains.

  4. Pyroelectric Energy Harvesting: With Thermodynamic-Based Cycles

    Directory of Open Access Journals (Sweden)

    Saber Mohammadi

    2012-01-01

    Full Text Available This work deals with energy harvesting from temperature variations using ferroelectric materials as a microgenerator. The previous researches show that direct pyroelectric energy harvesting is not effective, whereas thermodynamic-based cycles give higher energy. Also, at different temperatures some thermodynamic cycles exhibit different behaviours. In this paper pyroelectric energy harvesting using Lenoir and Ericsson thermodynamic cycles has been studied numerically and the two cycles were compared with each other. The material used is the PMN-25 PT single crystal that is a very interesting material in the framework of energy harvesting and sensor applications.

  5. Bishop score and labor induction

    OpenAIRE

    Radeka Gordana; Novakov-Mikić Aleksandra; Ivanović Ljiljana

    2002-01-01

    Introduction Induction of labor represents initiation of uterine contractions before their spontaneous onset. The aim of the study was to establish the role of Bishop score in prediction of labor induction in routine clinical work. Material and methods The study was a prospective blind, observational one. All patients had a vaginal examination prior to induction, during which Bishop score was evaluated. The mode of induction was either intravenous infusion of oxytocin or endovaginal prostagla...

  6. Stability Scores: Measuring Coalitional Stability

    OpenAIRE

    Feldman, Michal; Meir, Reshef; Tennenholtz, Moshe

    2011-01-01

    We introduce a measure for the level of stability against coalitional deviations, called \\emph{stability scores}, which generalizes widely used notions of stability in non-cooperative games. We use the proposed measure to compare various Nash equilibria in congestion games, and to quantify the effect of game parameters on coalitional stability. For our main results, we apply stability scores to analyze and compare the Generalized Second Price (GSP) and Vickrey-Clarke-Groves (VCG) ad auctions....

  7. Anatomy of Credit Scoring Models

    OpenAIRE

    Matías Alfredo Gutiérrez Girault

    2008-01-01

    Introduced in the 70´s, the use of credit scoring techniques became widespread in the 90´s thanks to the development of better statistical and computational resources. Nowadays almost all the financial intermediaries use these techniques, at least to originate the credits they grant. Credit scoring models are algorithms that in a mechanical way assess the credit risk of a loan applicant or an existing bank client, by means of statistical, mathematic, econometric or artificial intelligence dev...

  8. Computer scoring of the Levels of Emotional Awareness Scale.

    Science.gov (United States)

    Barchard, Kimberly A; Bajgar, Jane; Leaf, Duncan Ermini; Lane, Richard D

    2010-05-01

    The Levels of Emotional Awareness Scale (LEAS; Lane, Quinlan, Schwartz, Walker, & Zeitlan, 1990) is the most commonly used measure of differentiation and complexity in the use of emotion words and is associated with important clinical outcomes. Hand scoring the LEAS is time consuming. Existing programs for scoring open-ended responses cannot mimic LEAS hand scoring. Therefore, Leaf and Barchard (2006) developed the Program for Open-Ended Scoring (POES) to score the LEAS. In this article, we report a study in which the reliability and validity of POES scoring were examined. In the study, we used three participant types (adult community members, university students, children), three LEAS versions (paper based, computer based, and the LEAS for children), and a diverse set of criterion variables. Across this variety of conditions, the four POES scoring methods had internal consistencies and validities that were comparable to hand scoring, indicating that POES scoring can be used in clinical practice and other applied settings in which hand scoring is impractical. PMID:20479190

  9. A Net Energy-based Analysis for a Climate-constrained Sustainable Energy Transition

    CERN Document Server

    Sgouridis, Sgouris; Csala, Denes

    2015-01-01

    The transition from a fossil-based energy economy to one based on renewable energy is driven by the double challenge of climate change and resource depletion. Building a renewable energy infrastructure requires an upfront energy investment that subtracts from the net energy available to society. This investment is determined by the need to transition to renewable energy fast enough to stave off the worst consequences of climate change and, at the same time, maintain a sufficient net energy flow to sustain the world's economy and population. We show that a feasible transition pathway requires that the rate of investment in renewable energy should accelerate approximately by an order of magnitude if we are to stay within the range of IPCC recommendations.

  10. Recent Progress on PZT Based Piezoelectric Energy Harvesting Technologies

    Directory of Open Access Journals (Sweden)

    Min-Gyu Kang

    2016-02-01

    Full Text Available Energy harvesting is the most effective way to respond to the energy shortage and to produce sustainable power sources from the surrounding environment. The energy harvesting technology enables scavenging electrical energy from wasted energy sources, which always exist everywhere, such as in heat, fluids, vibrations, etc. In particular, piezoelectric energy harvesting, which uses a direct energy conversion from vibrations and mechanical deformation to the electrical energy, is a promising technique to supply power sources in unattended electronic devices, wireless sensor nodes, micro-electronic devices, etc., since it has higher energy conversion efficiency and a simple structure. Up to now, various technologies, such as advanced materials, micro- and macro-mechanics, and electric circuit design, have been investigated and emerged to improve performance and conversion efficiency of the piezoelectric energy harvesters. In this paper, we focus on recent progress of piezoelectric energy harvesting technologies based on PbZrxTi1-xO3 (PZT materials, which have the most outstanding piezoelectric properties. The advanced piezoelectric energy harvesting technologies included materials, fabrications, unique designs, and properties are introduced to understand current technical levels and suggest the future directions of piezoelectric energy harvesting.

  11. Model Property Based Material Balance and Energy Conservation Analysis for Process Industry Energy Transfer Systems

    OpenAIRE

    Fumin Ma; O’Hare, Gregory M.P.; Tengfei Zhang; Michael J. O’Grady

    2015-01-01

    Conventional historical data based material and energy balance analyses are static and isolated computations. Such methods cannot embody the cross-coupling effect of energy flow, material flow and information flow in the process industry; furthermore, they cannot easily realize the effective evaluation and comparison of different energy transfer processes by alternating the model module. In this paper, a novel method for material balance and energy conservation analysis of process industry en...

  12. Bases for the Creation of Electric Energy Price Estimate Model

    International Nuclear Information System (INIS)

    The paper presents the basic principles for the creation and introduction of a new model for the electric energy price estimate and its significant influence on the tariff system functioning. There is also a review of the model used presently for the electric energy price estimate which is based on the model of objectivized values of electric energy plants and production, transmission and distribution facilities, followed by proposed changes which would result in functional and organizational improvements within the electric energy system as the most complex subsystem of the whole power system. The model is based on substantial and functional connection of the optimization and analysis system with the electric energy economic dispatching, including marginal cost estimate and their influence on the tariff system as the main means in achieving better electric energy system's functioning quality. (author). 10 refs., 2 figs

  13. FACIAL GEOMETRIC BEAUTY SCORE BASED ON SEMI-SUPERVISED REGRESSION LEARNING%基于半监督回归学习的人脸几何美丽分数

    Institute of Scientific and Technical Information of China (English)

    戴礼青; 金忠; 孙明明

    2015-01-01

    基于人脸美学的迅速发展,对人脸的几何特征定义、几何特征规范化以及几何特征对判断人脸美与否的贡献进行研究。首先定义人脸几何美丽分数函数,然后将流形学习与半监督学习相结合,用流形上的半监督回归方法学习人脸几何美丽分数。为了突出几何特征,还验证了人脸表情与几何美丽分数之间的关系。与 K 近邻(KNN)、支持向量机(SVM)、C4.5决策树分类方法相比,通过实验验证,证明了所提方法的有效性和可行性。%Based on rapid development of facial aesthetics,we mainly study the definition of facial geometric feature,the normalisation of geometric features and the contribution of geometric features to judging whether the face is beauty or not.First,we define the facial geometric beauty score function,and then combine the manifold learning with semi-supervised learning,use semi-supervised regression on manifolds to learn geometric beauty score of faces.In order to highlight the geometric features,we also verify the relationship between facial expression and geometric beauty scores.Compared with KNN,SVM and C4.5 decision tree classification methods,the validity and the feasibility of the proposed methods are proved by experiment.

  14. MEMS based pyroelectric thermal energy harvester

    Science.gov (United States)

    Hunter, Scott R; Datskos, Panagiotis G

    2013-08-27

    A pyroelectric thermal energy harvesting apparatus for generating an electric current includes a cantilevered layered pyroelectric capacitor extending between a first surface and a second surface, where the first surface includes a temperature difference from the second surface. The layered pyroelectric capacitor includes a conductive, bimetal top electrode layer, an intermediate pyroelectric dielectric layer and a conductive bottom electrode layer. In addition, a pair of proof masses is affixed at a distal end of the layered pyroelectric capacitor to face the first surface and the second surface, wherein the proof masses oscillate between the first surface and the second surface such that a pyroelectric current is generated in the pyroelectric capacitor due to temperature cycling when the proof masses alternately contact the first surface and the second surface.

  15. Energy Relevant Materials: Investigations Based on First Principles

    OpenAIRE

    Delczeg-Czirjak, Erna-Krisztina

    2010-01-01

    Energy production, storage and efficient usage are all crucial factors for environmentally sound and sustainable future technologies. One important question concerns the refrigeration industry, where the energy efficiency of the presently used technologies is at best 40% of the theoretical Carnot limit. Magnetic refrigerators offer a modern low-energy demand and environmentally friendly alternative. Iron phosphide based materials have been proposed to be amongst the most promising candidates ...

  16. Is collaboration among scientists related to the citation impact of papers because their quality increases with collaboration? An analysis based on data from F1000Prime and normalized citation scores

    CERN Document Server

    Bornmann, Lutz

    2016-01-01

    In recent years, the relationship of collaboration among scientists and the citation impact of papers have been frequently investigated. Most of the studies show that the two variables are closely related: an increasing collaboration activity (measured in terms of number of authors, number of affiliations, and number of countries) is associated with an increased citation impact. However, it is not clear whether the increased citation impact is based on the higher quality of papers which profit from more than one scientist giving expert input or other (citation-specific) factors. Thus, the current study addresses this question by using two comprehensive datasets with publications (in the biomedical area) including quality assessments by experts (F1000Prime member scores) and citation data for the publications. The study is based on nearly 10,000 papers. Robust regression models are used to investigate the relationship between number of authors, number of affiliations, and number of countries, respectively, and...

  17. New scoring schema for finding motifs in DNA Sequences

    Directory of Open Access Journals (Sweden)

    Nowzari-Dalini Abbas

    2009-03-01

    Full Text Available Abstract Background Pattern discovery in DNA sequences is one of the most fundamental problems in molecular biology with important applications in finding regulatory signals and transcription factor binding sites. An important task in this problem is to search (or predict known binding sites in a new DNA sequence. For this reason, all subsequences of the given DNA sequence are scored based on an scoring function and the prediction is done by selecting the best score. By assuming no dependency between binding site base positions, most of the available tools for known binding site prediction are designed. Recently Tomovic and Oakeley investigated the statistical basis for either a claim of dependence or independence, to determine whether such a claim is generally true, and they presented a scoring function for binding site prediction based on the dependency between binding site base positions. Our primary objective is to investigate the scoring functions which can be used in known binding site prediction based on the assumption of dependency or independency in binding site base positions. Results We propose a new scoring function based on the dependency between all positions in biding site base positions. This scoring function uses joint information content and mutual information as a measure of dependency between positions in transcription factor binding site. Our method for modeling dependencies is simply an extension of position independency methods. We evaluate our new scoring function on the real data sets extracted from JASPAR and TRANSFAC data bases, and compare the obtained results with two other well known scoring functions. Conclusion The results demonstrate that the new approach improves known binding site discovery and show that the joint information content and mutual information provide a better and more general criterion to investigate the relationships between positions in the TFBS. Our scoring function is formulated by simple

  18. High-energy attosecond nanoplasmonic-based electron gun

    Science.gov (United States)

    Greig, S. R.; Elezzabi, A. Y.

    2016-03-01

    We present the design of an ultrafast conical lens based nanoplasmonic electron gun. Through excitation with a radially polarized laser pulse, and a combination of magnetostatic and spatial filtering, high energy electron packets with attosecond durations can be achieved.

  19. Energy demand forecasting method based on international statistical data

    International Nuclear Information System (INIS)

    Poland is in a transition phase from a centrally planned to a market economy; data collected under former economic conditions do not reflect a market economy. Final energy demand forecasts are based on the assumption that the economic transformation in Poland will gradually lead the Polish economy, technologies and modes of energy use, to the same conditions as mature market economy countries. The starting point has a significant influence on the future energy demand and supply structure: final energy consumption per capita in 1992 was almost half the average of OECD countries; energy intensity, based on Purchasing Power Parities (PPP) and referred to GDP, is more than 3 times higher in Poland. A method of final energy demand forecasting based on regression analysis is described in this paper. The input data are: output of macroeconomic and population growth forecast; time series 1970-1992 of OECD countries concerning both macroeconomic characteristics and energy consumption; and energy balance of Poland for the base year of the forecast horizon. (author). 1 ref., 19 figs, 4 tabs

  20. Energy saving behaviours: Development of a practice-based model

    International Nuclear Information System (INIS)

    Financial pressure and concern for the environment has meant many consumers are aware of the need to reduce their consumption of many resources, including energy, which is the focus of the present study. While potential energy use deterrents in the form of access constraints and price increases are forms of extrinsic control, it is not clear how effective these are at reducing consumption and, indeed, it is not clear if such measures are consistent with people's underlying energy saving motivations. Beyond behavioural motivations, people's desires to reduce energy can be thwarted (barriers) and/or supported by a variety of factors, some within their control, while others are perhaps less so. Using a practice-based framework and a qualitative focus group approach, this study presents an exploratory study of these issues. Policy suggestions for overcoming barriers, as well suggestions as to how energy saving behaviours can be supported are offered. - Highlights: • We obtained consumers views about energy saving motivations, barriers and support. • Attitudes towards energy saving are not sufficient to change behaviours. • A practice-based approach to understanding energy saving behaviours is applied. • A practice-based energy-cultures framework (PBECF) is developed. • Barriers and support factors are identified that can be conceptualised within a PBECF

  1. Monitoring and optimization of energy consumption of base transceiver stations

    International Nuclear Information System (INIS)

    The growth and development of the mobile phone network has led to an increased demand for energy by the telecommunications sector, with a noticeable impact on the environment. Monitoring of energy consumption is a great tool for understanding how to better manage this consumption and find the best strategy to adopt in order to maximize reduction of unnecessary usage of electricity. This paper reports on a monitoring campaign performed on six BSs (Base Transceiver Stations) located central Italy, with different technology, typology and technical characteristics. The study focuses on monitoring energy consumption and environmental parameters (temperature, noise, and global radiation), linking energy consumption with the load of telephone traffic and with the air conditioning functions used to cool the transmission equipment. Moreover, using experimental data collected, it is shown, with a Monte Carlo simulation based on power saving features, how the BS monitored could save energy. - Highlights: • Energy consumption and environmental parameters of a base transceiver system have been monitored. • Energy consumption is related to the air conditioning functions and to the load of telephone traffic. • Energy saving can be obtained by careful choice of cooling parameters and by turn off BS transceivers. • Energy saving parameters can be estimated by a simulation Monte Carlo method

  2. A structured approach to control of Salmonella Dublin in 10 Danish dairy herds based on risk scoring and test-and-manage procedures

    DEFF Research Database (Denmark)

    Nielsen, Liza Rosenbaum; Nielsen, Søren Saxmose

    2012-01-01

    routes of infection; 4) interpretation of repeated testing of individual animals to detect high-risk animals for special hygienic management or culling; and 5) diagnostic testing of different age groups and bulk tank milk to evaluate progress of control over time. Serology, true prevalence estimates and......The aim of this study was to describe a structured approach to effectively reduce Salmonella Dublin prevalence in infected dairy herds based on a step-wise procedure. Furthermore, the aim was to describe tools for management and monitoring, and to report on development in prevalence among young...

  3. Combined Cycle Fatigue Investigation Based on Energy Principle

    OpenAIRE

    Kalynenko Mykyta

    2016-01-01

    We present a modified energy-principle based model of fatigue damage accumulation in high temperature alloys usually used in gas turbine engine under combined high cycle fatigue and low cycle fatigue (LCF/HCF) loading conditions. Our model is based on the energy principle which includes a modified approximation formula that describes fatigue crack origin depending on the relative amplitude of stress intensity in the ranges of both high- and low-cycle fatigue under non-isothermal loading. Func...

  4. Hydrogen-based electrochemical energy storage

    Science.gov (United States)

    Simpson, Lin Jay

    2013-08-06

    An energy storage device (100) providing high storage densities via hydrogen storage. The device (100) includes a counter electrode (110), a storage electrode (130), and an ion conducting membrane (120) positioned between the counter electrode (110) and the storage electrode (130). The counter electrode (110) is formed of one or more materials with an affinity for hydrogen and includes an exchange matrix for elements/materials selected from the non-noble materials that have an affinity for hydrogen. The storage electrode (130) is loaded with hydrogen such as atomic or mono-hydrogen that is adsorbed by a hydrogen storage material such that the hydrogen (132, 134) may be stored with low chemical bonding. The hydrogen storage material is typically formed of a lightweight material such as carbon or boron with a network of passage-ways or intercalants for storing and conducting mono-hydrogen, protons, or the like. The hydrogen storage material may store at least ten percent by weight hydrogen (132, 134) at ambient temperature and pressure.

  5. Palliative chemotherapy in head and neck squamous cell cancer - What is best in Indian population? A time without symptoms, treatment toxicity score based study

    Directory of Open Access Journals (Sweden)

    V Anuradha

    2013-01-01

    Full Text Available Background: Patients with recurrent and metastatic head and neck Squamous Cell Cancer (HNSCC have poor prognosis with limited treatment options. In view of decimal prognosis, the treatment decision should include quality of life (QOL issues, cost-effectiveness besides the response rates and survival. Aim: Present retrospective analysis was conducted to evaluate efficacy (disease-free survival, pharmacoeconomics, and toxicity profile of four (4 different regimens, viz. gefitinib alone, gefitinib with methotrexate, methotrexate alone, or 5-FU with cisplatin. Materials and Methods: Case records between 2007 September and 2008 September were analyzed, 68 patients were found suitable for analysis. Patients received gefitinib (250 mg/day, methotrexate as 50 mg intramuscular weekly or a combination of the same or 5-FU 750 mg/m 2 /day for 4 days along with cisplatin 75 mg/m 2 /day on day 1 in 21-day cycle. Results: A total of 68 patients received therapy. Fifty-one patients have clinically meaningful response (stable disease + complete + partial responses (75% and had symptomatic improvement. The median progression-free survival was significantly superior in responders (those who achieved partial or complete response (8.4 months vs. 3.1 months, P=0.001. Methotrexate with gefitinib had maximum median survival and better overall QOL compared to the other treatment regimens. Weekly methotrexate is relatively cost-effective followed by methotrexate with gefitinib and gefitinib alone. 5-FU with cisplatin in our experience does not appear so attractive in view of high complication rates (when given in full doses and prolonged hospital stay. Conclusion: Based on the results of this retrospective analysis, methotrexate weekly as single agent or in combination with gefitinib appears as an attractive alternative regimen for patients with metastatic HNSCC including those having poor performance status. A prospective study was planned and submitted to the local

  6. Solar Energy Based Automated Irrigation System

    Directory of Open Access Journals (Sweden)

    Prof. Lodhi A. K.

    2013-09-01

    Full Text Available In the field of agriculture, use of proper method of irrigation is important because the main reason is the lack of rains {&} scarcity of land reservoir water. The continuous extraction of water from earth is reducing the water level due to which lot of land is coming slowly in the zones of un-irrigated land. Another very important reason of this is due to unplanned use of water due to which a significant amount of water goes waste. For this purpose; we use this automatic plant irrigation system. In this project we use solar energy which is used to operate the irrigation pump. The circuit comprises of sensor parts built using op-amp IC LM358. Op-amp are configured here as a comparator. Two stiff copper wires are inserted in the soil to sense whether the soil is wet or dry. The Microcontroller is used to control the whole system by monitoring the sensors and when sensors sense the dry condition then the microcontroller will send command to relay driver IC the contacts of which are used to switch on the motor and it will switch off the motor when all the sensors are in wet condition. The microcontroller does the above job as it receives the signal from the sensors through the output of the comparator, and these signals operate under the control of software which is stored in ROM of the Microcontroller. The condition of the pump i.e., ON/OFF is displayed on a 16X2 LCD

  7. Empathic veterinarians score cattle pain higher.

    Science.gov (United States)

    Norring, Marianna; Wikman, Ingela; Hokkanen, Ann-Helena; Kujala, Miiamaaria V; Hänninen, Laura

    2014-04-01

    The treatment of cattle pain often relies upon veterinarians. The aim of this study was to qualify the influence of veterinarians skills, attitudes, and empathy on cattle pain assesment and consequently disbudding pain management. A web-based questionnaire was sent to Finnish veterinary students in either the preclinical or clinical stage, and also to production-animal practice oriented veterinarians. The questionnaire recorded demographics, statements of opinions, pain scoring of cattle conditions and procedures. Empathy towards humans (Interpersonal Reactivity Index, IRI) and reworded IRI to measure empathy towards animals were also covered. The overall response rate was approximately 40%. The association between pain and empathy scores were analyzed by Pearsońs correlation, and the factors affecting pain scores and empathy towards animals analyzed using linear models. The need for pain medication of calves during disbudding was well recognized and the intention to treat such pain was very common. Higher mean scores for cattle pain were associated with greater empathy towards humans. On average, respondents' empathy towards animals was greater than towards humans, and was associated with respondents' empathy towards humans, family size and attachment to family pet. PMID:24685101

  8. Energy conservation technologies based on thermodynamic principles

    Energy Technology Data Exchange (ETDEWEB)

    Hirata, Masaru [Shibaura Institute of Technology of Technology, Tokyo (Japan)

    1996-12-31

    In order to reduce CO{sub 2} emission to prevent global warming, the most promising way for electric generation in the Northeast Asia is to introduce cogeneration and {open_quotes}repowering{close_quotes} technologies based on high temperature gas turbines fueled by natural gas. Especially the old type coal burning boiler-steam turbine plants should be retrofit by introducing gas turbines to become highly efficient combined cycle. Same technologies should be applied to the old garbage incineration plants and/or even to the nuclear power plants. The exhaust heat or steam should become much increased and it should be utilized as the process heat for industries or heat supply as the distinct heating or cooling for residential area. This paper introduces a brief survey of these new technologies.

  9. Short-term precision assessment of trabecular bone score and bone mineral density using dual-energy X-ray absorptiometry with different scan modes: an in vivo study

    Energy Technology Data Exchange (ETDEWEB)

    Bandirali, Michele; Poloni, Alessandro; Messina, Carmelo; Petrini, Marcello [Universita degli Studi di Milano, Scuola di Specializzazione in Radiodiagnostica, Milano (Italy); Sconfienza, Luca Maria; Sardanelli, Francesco [Unita di Radiologia, IRCCS Policlinico San Donato, San Donato Milanese (Italy); Universita degli Studi di Milano, Dipartimento di Scienze Biomediche per la Salute, San Donato Milanese (Italy); Papini, Giacomo Davide Edoardo; Di Leo, Giovanni [Unita di Radiologia, IRCCS Policlinico San Donato, San Donato Milanese (Italy); Ulivieri, Fabio Massimo [IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Mineralometria Ossea Computerizzata e Ambulatorio Malattie Metabolismo Minerale e Osseo, Servizio di Medicina Nucleare, Milano (Italy)

    2015-07-15

    We estimated the in vivo reproducibility of trabecular bone score (TBS) from dual-energy X-ray absorptiometry (DXA) using different imaging modes to be compared to that of bone mineral density (BMD). We enrolled 30 patients for each imaging mode: fast-array, array, high definition. Each patient underwent two DXA examinations with in-between repositioning. BMD and TBS were obtained according to the International Society for Clinical Densitometry guidelines. The coefficient of variation (CoV) was calculated as the ratio between root mean square standard deviation and mean, percent least significant change (LSC) as 2.77 x CoV, reproducibility as the complement to 100 % LSC. Fast-array imaging mode resulted in 0.8 % CoV and 2.1 % LSC for BMD, 1.9 % and 5.3 % for TBS, respectively; array imaging mode resulted in 0.7 % and 2.0 % for BMD, 1.9 % and 5.2 %, for TBS; high-definition imaging mode resulted in 0.7 % and 2.0 %, for BMD; 2.0 % and 5.4 % for TBS, respectively. Reproducibility of TBS (95 %) was significantly lower than that of BMD (98 %) (p < 0.012). Difference in reproducibility among the imaging modes was not significant for either BMD or TBS (p = 0.942). While TBS reproducibility was significantly lower than that of BMD, differences among imaging modes were not significant for both TBS and BMD. (orig.)

  10. Feasibility and impact analysis of a renewable energy source (RES)-based energy system in Korea

    International Nuclear Information System (INIS)

    In this study, we analyze the feasibility and impacts of a renewable energy source (RES)-based electricity supply system of future Korea. To achieve this goal, we first developed different scenarios for increasing the contribution of RES by lowering the rate of i) nuclear power, ii) thermal power, iii) both nuclear and thermal power, and iv) these scenarios with real-world constraints. Based on the generated scenarios, we then specified the established systems with practical strategies which encourage different renewable sources (wind, solar photovoltaic, biomass, and waste). Finally, we analyzed the impacts of the established RES-based systems according to various criteria: the total required cost, the dependence on imported energy, CO2 emissions, and land use. The results show that the RES-based system that utilizes wind energy as its main source by steadily decreasing the rate of thermal power for electricity generation is the most affordable for future Korean electricity system. We also identify the merits and drawbacks of the analyzed systems and provide relevant recommendations for the establishment of a sustainable energy system for Korea. These findings will support policy makers in integrating quantitative assessments into energy-related policy design and implementation. - Highlights: • We model and analyze RES-based electricity supply system in Korea. • Impact analysis includes: economic, energy security, environmental protection aspects. • We also evaluate different strategies to establish RES-based system. • We show that wind energy-based system is the most affordable for Korea

  11. Rasch-family models are more valuable than score-based approaches for analysing longitudinal patient-reported outcomes with missing data.

    Science.gov (United States)

    de Bock, Elodie; Hardouin, Jean-Benoit; Blanchin, Myriam; Le Neel, Tanguy; Kubis, Gildas; Bonnaud-Antignac, Angélique; Dantan, Etienne; Sébille, Véronique

    2013-12-16

    The objective was to compare classical test theory and Rasch-family models derived from item response theory for the analysis of longitudinal patient-reported outcomes data with possibly informative intermittent missing items. A simulation study was performed in order to assess and compare the performance of classical test theory and Rasch model in terms of bias, control of the type I error and power of the test of time effect. The type I error was controlled for classical test theory and Rasch model whether data were complete or some items were missing. Both methods were unbiased and displayed similar power with complete data. When items were missing, Rasch model remained unbiased and displayed higher power than classical test theory. Rasch model performed better than the classical test theory approach regarding the analysis of longitudinal patient-reported outcomes with possibly informative intermittent missing items mainly for power. This study highlights the interest of Rasch-based models in clinical research and epidemiology for the analysis of incomplete patient-reported outcomes data. PMID:24346165

  12. Action dependent heuristic dynamic programming based residential energy scheduling with home energy inter-exchange

    International Nuclear Information System (INIS)

    Highlights: • The algorithm is developed in the two-household energy management environment. • We develop the absent energy penalty cost for the first time. • The algorithm has ability to keep adapting in real-time operations. • Its application can lower total costs and achieve better load balancing. - Abstract: Residential energy scheduling is a hot topic nowadays in the background of energy saving and environmental protection worldwide. To achieve this objective, a new residential energy scheduling algorithm is developed for energy management, based on action dependent heuristic dynamic programming. The algorithm works under the circumstance of residential real-time pricing and two adjacent housing units with energy inter-exchange, which can reduce the overall cost and enhance renewable energy efficiency after long-term operation. It is designed to obtain the optimal control policy to manage the directions and amounts of electricity energy flux. The algorithm’s architecture is mainly constructed based on neural networks, denoting the learned characteristics in the linkage of layers. To get close to real situations, many constraints such as maximum charging/discharging power of batteries are taken into account. The absent energy penalty cost is developed for the first time as a part of the performance index function. When the environment changes, the residential energy scheduling algorithm gains new features and keeps adapting in real-time operations. Simulation results show that the developed algorithm is beneficial to energy conversation

  13. Roadmap Toward a Predictive Performance-based Commercial Energy Code

    Energy Technology Data Exchange (ETDEWEB)

    Rosenberg, Michael I.; Hart, Philip R.

    2014-10-01

    Energy codes have provided significant increases in building efficiency over the last 38 years, since the first national energy model code was published in late 1975. The most commonly used path in energy codes, the prescriptive path, appears to be reaching a point of diminishing returns. The current focus on prescriptive codes has limitations including significant variation in actual energy performance depending on which prescriptive options are chosen, a lack of flexibility for designers and developers, and the inability to handle control optimization that is specific to building type and use. This paper provides a high level review of different options for energy codes, including prescriptive, prescriptive packages, EUI Target, outcome-based, and predictive performance approaches. This paper also explores a next generation commercial energy code approach that places a greater emphasis on performance-based criteria. A vision is outlined to serve as a roadmap for future commercial code development. That vision is based on code development being led by a specific approach to predictive energy performance combined with building specific prescriptive packages that are designed to be both cost-effective and to achieve a desired level of performance. Compliance with this new approach can be achieved by either meeting the performance target as demonstrated by whole building energy modeling, or by choosing one of the prescriptive packages.

  14. On promotion of base technologies of atomic energy

    International Nuclear Information System (INIS)

    In the long term plan of atomic energy development and utilization decided in June, 1987 by the Atomic Energy Commission, it was recognized that hereafter, the opening-up of the new potential that atomic energy possesses should be aimed at, and the policy was shown so that the research and development hereafter place emphasis on the creative and innovative region which causes large technical innovation, by which the spreading effect to general science and technology can be expected, and the development of the base technologies that connect the basic research and project development is promoted. The trend of atomic energy development so far, the change of the situation surrounding atomic energy, the direction of technical development of atomic energy hereafter and the base technologies are discussed. The concept of the technical development of materilas, artificial intelligence, lasers, and the evaluation and reduction of radiation risks used for atomic energy is described. As the development plan of atomic energy base technologies, the subjects of technical development, the future image of technical development, the efficient promotion of the development and so on are shown. (Kato, I.)

  15. ENERGY OPTIMIZATION IN CLUSTER BASED WIRELESS SENSOR NETWORKS

    Directory of Open Access Journals (Sweden)

    T. SHANKAR

    2014-04-01

    Full Text Available Wireless sensor networks (WSN are made up of sensor nodes which are usually battery-operated devices, and hence energy saving of sensor nodes is a major design issue. To prolong the networks lifetime, minimization of energy consumption should be implemented at all layers of the network protocol stack starting from the physical to the application layer including cross-layer optimization. Optimizing energy consumption is the main concern for designing and planning the operation of the WSN. Clustering technique is one of the methods utilized to extend lifetime of the network by applying data aggregation and balancing energy consumption among sensor nodes of the network. This paper proposed new version of Low Energy Adaptive Clustering Hierarchy (LEACH, protocols called Advanced Optimized Low Energy Adaptive Clustering Hierarchy (AOLEACH, Optimal Deterministic Low Energy Adaptive Clustering Hierarchy (ODLEACH, and Varying Probability Distance Low Energy Adaptive Clustering Hierarchy (VPDL combination with Shuffled Frog Leap Algorithm (SFLA that enables selecting best optimal adaptive cluster heads using improved threshold energy distribution compared to LEACH protocol and rotating cluster head position for uniform energy dissipation based on energy levels. The proposed algorithm optimizing the life time of the network by increasing the first node death (FND time and number of alive nodes, thereby increasing the life time of the network.

  16. Material identification based upon energy-dependent attenuation of neutrons

    Science.gov (United States)

    Marleau, Peter

    2015-10-06

    Various technologies pertaining to identifying a material in a sample and imaging the sample are described herein. The material is identified by computing energy-dependent attenuation of neutrons that is caused by presence of the sample in travel paths of the neutrons. A mono-energetic neutron generator emits the neutron, which is downscattered in energy by a first detector unit. The neutron exits the first detector unit and is detected by a second detector unit subsequent to passing through the sample. Energy-dependent attenuation of neutrons passing through the sample is computed based upon a computed energy of the neutron, wherein such energy can be computed based upon 1) known positions of the neutron generator, the first detector unit, and the second detector unit; or 2) computed time of flight of neutrons between the first detector unit and the second detector unit.

  17. FEL based energy driver for inertial confinement fusion

    International Nuclear Information System (INIS)

    An FEL based energy driver for inertial confinement fusion (ICF) is proposed. The key element of the scheme is a free electron laser system. Novel technical solutions reveal a possibility to construct the FEL system operating at a radiation wavelength λ= 0.5 μm and providing a flash energy E 1 MJ and brightness 4 x1022 W cm-2sr-1 within the steering pulse duration 0.1-2 ns. The total energy efficiency of the proposed ICF energy driver is about 11% and repetition rate is 40 Hz. It is shown that the FEL based ICF energy driver may be constructed at the present level of accelerator technique R and D. (orig.)

  18. Monitoring and optimization of energy consumption of base transceiver stations

    CERN Document Server

    Spagnuolo, Antonio; Vetromile, Carmela; Formosi, Roberto; Lubritto, Carmine

    2015-01-01

    The growth and development of the mobile phone network has led to an increased demand for energy by the telecommunications sector, with a noticeable impact on the environment. Monitoring of energy consumption is a great tool for understanding how to better manage this consumption and find the best strategy to adopt in order to maximize reduction of unnecessary usage of electricity. This paper reports on a monitoring campaign performed on six Base Transceiver Stations (BSs) located central Italy, with different technology, typology and technical characteristics. The study focuses on monitoring energy consumption and environmental parameters (temperature, noise, and global radiation), linking energy consumption with the load of telephone traffic and with the air conditioning functions used to cool the transmission equipment. Moreover, using experimental data collected, it is shown, with a Monte Carlo simulation based on power saving features, how the BS monitored could save energy.

  19. Building a Scoring Model for Small and Medium Enterprises

    Directory of Open Access Journals (Sweden)

    Răzvan Constantin CARACOTA

    2010-09-01

    Full Text Available The purpose of the paper is to produce a scoring model for small and medium enterprises seeking financing through a bank loan. To analyze the loan application, scoring system developed for companies is as follows: scoring quantitative factors and scoring qualitative factors. We have estimated the probability of default using logistic regression. Regression coefficients determination was made with a solver in Excel using five ratios as input data. Analyses and simulations were conducted on a sample of 113 companies, all accepted for funding. Based on financial information obtained over two years, 2007 and 2008, we could establishe and appreciate the default value.

  20. TRII: A Probabilistic Scoring of Drosophila melanogaster Translation Initiation Sites

    Directory of Open Access Journals (Sweden)

    Rice Michael D

    2010-01-01

    Full Text Available Relative individual information is a measurement that scores the quality of DNA- and RNA-binding sites for biological machines. The development of analytical approaches to increase the power of this scoring method will improve its utility in evaluating the functions of motifs. In this study, the scoring method was applied to potential translation initiation sites in Drosophila to compute Translation Relative Individual Information (TRII scores. The weight matrix at the core of the scoring method was optimized based on high-confidence translation initiation sites identified by using a progressive partitioning approach. Comparing the distributions of TRII scores for sites of interest with those for high-confidence translation initiation sites and random sequences provides a new methodology for assessing the quality of translation initiation sites. The optimized weight matrices can also be used to describe the consensus at translation initiation sites, providing a quantitative measure of preferred and avoided nucleotides at each position.

  1. Interpreting Force Concept Inventory Scores: Normalized Gain and SAT Scores

    Science.gov (United States)

    Coletta, Vincent P.; Phillips, Jeffrey A.; Steinert, Jeffrey J.

    2007-01-01

    Preinstruction SAT scores and normalized gains (G) on the force concept inventory (FCI) were examined for individual students in interactive engagement (IE) courses in introductory mechanics at one high school (N=335) and one university (N=292), and strong, positive correlations were found for both populations (r=0.57 and r=0.46, respectively).…

  2. Automatic face alignment by maximizing similarity score

    OpenAIRE

    Boom, Bas; Spreeuwers, Luuk; Veldhuis, Raymond; Fred, A.; Jain, A. K.

    2007-01-01

    Accurate face registration is of vital importance to the performance of a face recognition algorithm. We propose a face registration method which searches for the optimal alignment by maximizing the score of a face recognition algorithm. In this paper we investigate the practical usability of our face registration method. Experiments show that our registration method achieves better results in face verification than the landmark based registration method. We even obtain face verification resu...

  3. Net-Zero Energy Buildings: A Classification System Based on Renewable Energy Supply Options

    Energy Technology Data Exchange (ETDEWEB)

    Pless, S.; Torcellini, P.

    2010-06-01

    A net-zero energy building (NZEB) is a residential or commercial building with greatly reduced energy needs. In such a building, efficiency gains have been made such that the balance of energy needs can be supplied with renewable energy technologies. Past work has developed a common NZEB definition system, consisting of four well-documented definitions, to improve the understanding of what net-zero energy means. For this paper, we created a classification system for NZEBs based on the renewable sources a building uses.

  4. Energy-analysis of the total nuclear energy cycle based on light water reactors

    International Nuclear Information System (INIS)

    The energy economy of the total nuclear energy cycle is investigated. Attention is paid to the importance of fossil fuel saving by using nuclear energy. The energy analysis is based on the construction and operation of power plants with an electric output of 1000MWe. Light water moderated reactors with a 2.7 - 3.2% enriched uranium core are considered. Additionally, the whole fuel cycle including ore winning and refining, enrichment and fuel element manufacturing and reprocessing has been taken into account. Neither radioactive waste storage problems nor safety problems related to the nuclear energy cycle and safeguarding have been dealt with, as exhaustive treatments can be found elswhere

  5. A Bootstrap Procedure of Propensity Score Estimation

    Science.gov (United States)

    Bai, Haiyan

    2013-01-01

    Propensity score estimation plays a fundamental role in propensity score matching for reducing group selection bias in observational data. To increase the accuracy of propensity score estimation, the author developed a bootstrap propensity score. The commonly used propensity score matching methods: nearest neighbor matching, caliper matching, and…

  6. Skin scoring in systemic sclerosis

    DEFF Research Database (Denmark)

    Zachariae, Hugh; Bjerring, Peter; Halkier-Sørensen, Lars; Heickendorff, Lene; Søndergaard, Klaus

    1994-01-01

    Forty-one patients with systemic sclerosis were investigated with a new and simple skin score method measuring the degree of thickening and pliability in seven regions together with area involvement in each region. The highest values were, as expected, found in diffuse cutaneous systemic sclerosis...... (type III SS) and the lowest in limited cutaneous systemic sclerosis (type I SS) with no lesions extending above wrists and ancles. A positive correlation was found to the aminoterminal propeptide of type III procollagen, a serological marker for synthesis of type III collagen. The skin score is...

  7. Calcium score of small coronary calcifications on multidetector computed tomography

    DEFF Research Database (Denmark)

    Groen, J M; Kofoed, K F; Zacho, M;

    2013-01-01

    Multi detector computed tomography (MDCT) underestimates the coronary calcium score as compared to electron beam tomography (EBT). Therefore clinical risk stratification based on MDCT calcium scoring may be inaccurate. The aim of this study was to assess the feasibility of a new phantom which...

  8. Checklist for Evaluating SREB-SCORE Learning Objects

    Science.gov (United States)

    Southern Regional Education Board (SREB), 2007

    2007-01-01

    This checklist is based on "Evaluation Criteria for SREB-SCORE Learning Objects" and is designed to help schools and colleges determine the quality and effectiveness of learning objects. It is suggested that each learning object be rated to the extent to which it meets the criteria and the SREB-SCORE definition of a learning object. A learning…

  9. Score normalization using logistic regression with expected parameters

    NARCIS (Netherlands)

    Aly, Robin

    2014-01-01

    State-of-the-art score normalization methods use generative models that rely on sometimes unrealistic assumptions. We propose a novel parameter estimation method for score normalization based on logistic regression. Experiments on the Gov2 and CluewebA collection indicate that our method is consiste

  10. Examining Exam Reviews: A Comparison of Exam Scores and Attitudes

    Science.gov (United States)

    Hackathorn, Jana; Cornell, Kathryn; Garczynski, Amy M.; Solomon, Erin D.; Blankmeyer, Katheryn E.; Tennial, Rachel E.

    2012-01-01

    Instructors commonly use exam reviews to help students prepare for exams and to increase student success. The current study compared the effects of traditional, trivia, and practice test-based exam reviews on actual exam scores, as well as students' attitudes toward each review. Findings suggested that students' exam scores were significantly…

  11. Resource management tools based on renewable energy sources

    Science.gov (United States)

    Jannson, Tomasz; Forrester, Thomas; Boghrat, Pedram; Pradhan, Ranjit; Kostrzewski, Andrew

    2012-06-01

    Renewable energy is an important source of power for unattended sensors (ground, sea, air), tagging systems, and other remote platforms for Homeland Security and Homeland Defense. Also, Command, Control, Communication, and Intelligence (C3I) systems and technologies often require renewable energy sources for information assurance (IA), in general, and anti-tampering (AT), in particular. However, various geophysical and environmental conditions determine different types of energy harvesting: solar, thermal, vibration, acoustic, hydraulic, wind, and others. Among them, solar energy is usually preferable, but, both a solar habitat and the necessity for night operation can create a need for other types of renewable energy. In this paper, we introduce figures of merit (FoMs) for evaluating preferences of specific energy sources, as resource management tools, based on geophysical conditions. Also, Battery Systemic Modeling is discussed.

  12. The scoring of movements in sleep.

    Science.gov (United States)

    Walters, Arthur S; Lavigne, Gilles; Hening, Wayne; Picchietti, Daniel L; Allen, Richard P; Chokroverty, Sudhansu; Kushida, Clete A; Bliwise, Donald L; Mahowald, Mark W; Schenck, Carlos H; Ancoli-Israel, Sonia

    2007-03-15

    The International Classification of Sleep Disorders (ICSD-2) has separated sleep-related movement disorders into simple, repetitive movement disorders (such as periodic limb movements in sleep [PLMS], sleep bruxism, and rhythmic movement disorder) and parasomnias (such as REM sleep behavior disorder and disorders of partial arousal, e.g., sleep walking, confusional arousals, night terrors). Many of the parasomnias are characterized by complex behaviors in sleep that appear purposeful, goal directed and voluntary but are outside the conscious awareness of the individual and therefore inappropriate. All of the sleep-related movement disorders described here have specific polysomnographic findings. For the purposes of developing and/or revising specifications and polysomnographic scoring rules, the AASM Scoring Manual Task Force on Movements in Sleep reviewed background literature and executed evidence grading of 81 relevant articles obtained by a literature search of published articles between 1966 and 2004. Subsequent evidence grading identified limited evidence for reliability and/or validity for polysomnographic scoring criteria for periodic limb movements in sleep, REM sleep behavior disorder, and sleep bruxism. Published scoring criteria for rhythmic movement disorder, excessive fragmentary myoclonus, and hypnagogic foot tremor/alternating leg muscle activation were empirical and based on descriptive studies. The literature review disclosed no published evidence defining clinical consequences of excessive fragmentary myoclonus or hypnagogic foot tremor/alternating leg muscle activation. Because of limited or absent evidence for reliability and/or validity, a standardized RAND/UCLA consensus process was employed for recommendation of specific rules for the scoring of sleep-associated movements. PMID:17557425

  13. Assessing of energy policies based on Turkish agriculture:

    International Nuclear Information System (INIS)

    In this study, the current energy status of Turkey and the effects of national energy policies on Turkish agricultural support policies are discussed for both current and future requirements. Turkey is an energy-importing country producing 30 mtoe (million tons of oil equivalent) energy but consuming 80 mtoe. The energy import ratio of Turkey is 65-70% and the majority of this import is based on petroleum and natural gas. Furthermore, while world energy demand increases by 1.8% annually, Turkey's energy demand increases by about 8%. Although energy consumption in agriculture is much lower than the other sectors in Turkey, energy use as both input and output of agricultural sector is a very important issue due to its large agricultural potential and rural area. Total agricultural land area is 27.8 million hectares and about 66.5% of this area is devoted for cereal production. On the other hand, Turkey has over 4 million agricultural farm holdings of which 70-75% is engaged in cereal production. Machinery expenses, mainly diesel, constitute 30-50% of total variable expenses in cereal production costs. It is observed that energy policies pursued in agriculture have been directly affected by diesel prices in Turkey. Therefore, support policy tools for using diesel and electricity in agriculture are being pursued by the Turkish government

  14. Assessing of energy policies based on Turkish agriculture:

    Energy Technology Data Exchange (ETDEWEB)

    Sayin, Cengiz [Department of Agricultural Economics, Akdeniz University, 07070 Antalya (Turkey)] e-mail: csayin@akdeniz.edu.tr; Nisa Mencet, M. [Department of Agricultural Economics, Akdeniz University, 07070 Antalya (Turkey); Ozkan, Burhan [Department of Agricultural Economics, Akdeniz University, 07070 Antalya (Turkey)] e-mail: bozkan@akdeniz.edu.tr

    2005-12-01

    In this study, the current energy status of Turkey and the effects of national energy policies on Turkish agricultural support policies are discussed for both current and future requirements. Turkey is an energy-importing country producing 30 mtoe (million tons of oil equivalent) energy but consuming 80 mtoe. The energy import ratio of Turkey is 65-70% and the majority of this import is based on petroleum and natural gas. Furthermore, while world energy demand increases by 1.8% annually, Turkey's energy demand increases by about 8%. Although energy consumption in agriculture is much lower than the other sectors in Turkey, energy use as both input and output of agricultural sector is a very important issue due to its large agricultural potential and rural area. Total agricultural land area is 27.8 million hectares and about 66.5% of this area is devoted for cereal production. On the other hand, Turkey has over 4 million agricultural farm holdings of which 70-75% is engaged in cereal production. Machinery expenses, mainly diesel, constitute 30-50% of total variable expenses in cereal production costs. It is observed that energy policies pursued in agriculture have been directly affected by diesel prices in Turkey. Therefore, support policy tools for using diesel and electricity in agriculture are being pursued by the Turkish government.

  15. CD-HPF: New Habitability Score Via Data Analytic Modeling

    CERN Document Server

    Bora, Kakoli; Agrawal, Surbhi; Safonova, Margarita; Routh, Swati; Narasimhamurthy, Anand

    2016-01-01

    The search for life on the planets outside the Solar System can be broadly classified into the following: looking for Earth-like conditions or the planets similar to the Earth (Earth similarity), and looking for the possibility of life in a form known or unknown to us (habitability). The two frequently used indices, ESI and PHI, describe heuristic methods to score similarity/habitability in the efforts to categorize different exoplanets or exomoons. ESI, in particular, considers Earth as the reference frame for habitability and is a quick screening tool to categorize and measure physical similarity of any planetary body with the Earth. The PHI assesses the probability that life in some form may exist on any given world, and is based on the essential requirements of known life: a stable and protected substrate, energy, appropriate chemistry and a liquid medium. We propose here a different metric, a Cobb-Douglas Habitability Score (CDHS), based on Cobb-Douglas habitability production function (CD-HPF), which co...

  16. LSAT Scores of Economics Majors.

    Science.gov (United States)

    Nieswiadomy, Michael

    1998-01-01

    Argues that economics education provides many benefits to students, including preparation for law school. Examines the ranking of economics majors on the Law School Admission Test (LSAT). Finds that among the 14 majors having more than 2,000 students take the LSAT, economics students received the highest average score. (DSK)

  17. The persistence of depression score

    NARCIS (Netherlands)

    Spijker, J.; de Graaf, R.; Ormel, J.; Nolen, W. A.; Grobbee, D. E.; Burger, H.

    2006-01-01

    Objective: To construct a score that allows prediction of major depressive episode (MDE) persistence in individuals with MDE using determinants of persistence identified in previous research. Method: Data were derived from 250 subjects from the general population with new MDE according to DSM-III-R.

  18. Analysis of renewable energy sources and electric vehicle penetration into energy systems predominantly based on lignite

    Science.gov (United States)

    Dedinec, A.; Jovanovski, B.; Gajduk, A.; Markovska, N.; Kocarev, L.

    2016-05-01

    We consider an integration of renewable energy into transport and electricity sectors through vehicle to grid (V2G) technologies for an energy system that is predominantly based on lignite. The national energy system of Macedonia is modeled using EnergyPLAN which integrates energy for electricity, transport and heat, and includes hourly fluctuations in human needs and the environment. We show that electric-vehicles can provide the necessary storage enabling a fully renewable energy profile for Macedonia that can match the country's growing demand for energy. Furthermore, a large penetration of electric vehicles leads to a dramatic reduction of 47% of small particles and other air pollutants generated by car traffic in 2050.

  19. Analysis of renewable energy sources and electric vehicle penetration into energy systems predominantly based on lignite

    CERN Document Server

    Dedinec, Aleksandar; Gajduk, Andrej; Markovska, Natasa; Kocarev, Ljupco

    2016-01-01

    We consider an integration of renewable energy into transport and electricity sectors through vehicle to grid (V2G) technologies for an energy system that is predominantly based on lignite. The national energy system of Macedonia is modeled using EnergyPLAN which integrates energy for electricity, transport and heat, and includes hourly fluctuations in human needs and the environment. We show that electric-vehicles can provide the necessary storage enabling a fully renewable energy profile for Macedonia that can match the country's growing demand for energy. Furthermore, a large penetration of electric vehicles leads to a dramatic reduction of 47% of small particles and other air pollutants generated by car traffic in 2050.

  20. Bishop score and labor induction

    Directory of Open Access Journals (Sweden)

    Radeka Gordana

    2002-01-01

    Full Text Available Introduction Induction of labor represents initiation of uterine contractions before their spontaneous onset. The aim of the study was to establish the role of Bishop score in prediction of labor induction in routine clinical work. Material and methods The study was a prospective blind, observational one. All patients had a vaginal examination prior to induction, during which Bishop score was evaluated. The mode of induction was either intravenous infusion of oxytocin or endovaginal prostaglandins. The induction was considered successful if vaginal delivery took place within 24 hours from the onset of induction. Results There were 100 patients, and induction was successful in 74% and unsuccessful in 26%. Mean Bishop score in group A was 5.65 (SD 1.40, 95% CI 5.27 - 6.03, and in group B 4.15 (SD 1.04, 95% CI 3.66 - 4.63 (p < 0.01. Statistical analysis of the area under the ROC curve showed that Bishop score is a good and reliable predictor of the outcome of labor induction (0.816, 95% CI od 0.710 - 0.896, with the best statistical performances at the cut-off value of 5 (sensitivity 65.5% specificity 95%, PPV 97.3%, NPV 50%. Conclusion In our study Bishop score proved to be a reliable and good method for prediction of the outcome of pregnancy if a single, experienced operator evaluates it, with best statistical performances at the cut-off value more than 5 (sensitivity 65.5%, specificity 95%, PPV 97.3%, NPV 50%. The next step would be introduction of more operators, of different skills and experience and subsequent further testing of the method in different conditions.

  1. A Mixed QM/MM Scoring Function to Predict Protein-Ligand Binding Affinity

    OpenAIRE

    Hayik, Seth A.; Dunbrack, Roland; Merz, Kenneth M.

    2010-01-01

    Computational methods for predicting protein-ligand binding free energy continue to be popular as a potential cost-cutting method in the drug discovery process. However, accurate predictions are often difficult to make as estimates must be made for certain electronic and entropic terms in conventional force field based scoring functions. Mixed quantum mechanics/molecular mechanics (QM/MM) methods allow electronic effects for a small region of the protein to be calculated, treating the remaini...

  2. Requirements for energy based constitutive modeling in tire mechanics

    Science.gov (United States)

    Luchini, John R.; Peters, Jim M.; Mars, Will V.

    1995-01-01

    The history, requirements, and theoretical basis of a new energy based constitutive model for (rubber) material elasticity, hysteresis, and failure are presented. Energy based elasticity is handled by many constitutive models, both in one dimension and in three dimensions. Conversion of mechanical energy to heat can be modeled with viscoelasticity or as structural hysteresis. We are seeking unification of elasticity, hysteresis, and failure mechanisms such as fatigue and wear. An energy state characterization for failure criteria of (rubber) materials may provide this unification and also help explain the interaction of temperature effects with failure mechanisms which are described as creation of growth of internal crack surface. Improved structural modeling of tires with FEM should result from such a unified constitutive theory. The theory will also guide experimental work and should enable better interpretation of the results of computational stress analyses.

  3. Requirements for energy based constitutive modeling in tire mechanics

    Science.gov (United States)

    Luchini, John R.; Peters, Jim M.; Mars, Will V.

    1995-08-01

    The history, requirements, and theoretical basis of a new energy based constitutive model for (rubber) material elasticity, hysteresis, and failure are presented. Energy based elasticity is handled by many constitutive models, both in one dimension and in three dimensions. Conversion of mechanical energy to heat can be modeled with viscoelasticity or as structural hysteresis. We are seeking unification of elasticity, hysteresis, and failure mechanisms such as fatigue and wear. An energy state characterization for failure criteria of (rubber) materials may provide this unification and also help explain the interaction of temperature effects with failure mechanisms which are described as creation of growth of internal crack surface. Improved structural modeling of tires with FEM should result from such a unified constitutive theory. The theory will also guide experimental work and should enable better interpretation of the results of computational stress analyses.

  4. A comprehensible SOM-based scoring system.

    OpenAIRE

    Huysmans, Johan; Baesens, Bart; Vanthienen, Jan; Perner, P.; Imiya, A

    2005-01-01

    The significant growth of consumer credit has resulted in a wide range of statistical and non-statistical methods for classifying applicants in 'good' and 'bad' risk categories. Traditionally, (logistic) regression used to be one of the most popular methods for this task, but recently some newer techniques like neural networks and support vector machines have shown excellent classification performance. Self-organizing maps (SOMs) have existed for decades and although they have been used in va...

  5. A comprehensible SOM-based scoring system

    OpenAIRE

    Huysmans, Johan; Baesens, Bart; Vanthienen, Jan

    2005-01-01

    The significant growth of consumer credit has resulted in a wide range of statistical and non-statistical methods for classifying applicants in 'good' and 'bad' risk categories. Traditionally, (logistic) regression used to be one of the most popular methods for this task, but recently some newer techniques like neural networks and support vector machines have shown excellent classification performance. Self-organizing maps (SOMs) have existed for decades and although they have been used in va...

  6. Energy efficient cluster-based routing in wireless sensor networks

    OpenAIRE

    Zeghilet, Houda; Badache, Nadjib; Maimour, Moufida

    2009-01-01

    Because of the lack of a global naming scheme, routing protocols in sensor networks usually use flooding to select paths and deliver data. This process although simple and effective, is very costly in terms of energy consumption, an important design issue in sensor networks routing protocols. Cluster-based routing is one solution to save energy. In this paper, we propose a combination of an improved clustering algorithm and directed diffusion, a well-known data-centric routing paradigm in sen...

  7. Deep Structured Energy Based Models for Anomaly Detection

    OpenAIRE

    Zhai, Shuangfei; Cheng, Yu; Lu, Weining; Zhang, Zhongfei

    2016-01-01

    In this paper, we attack the anomaly detection problem by directly modeling the data distribution with deep architectures. We propose deep structured energy based models (DSEBMs), where the energy function is the output of a deterministic deep neural network with structure. We develop novel model architectures to integrate EBMs with different types of data such as static data, sequential data, and spatial data, and apply appropriate model architectures to adapt to the data structure. Our trai...

  8. Fostering energy efficiency in buildings through aerogel-based renders

    OpenAIRE

    Ibrahim, Mohamad; Wurtz, Etienne; Achard, Patrick; Biwole, Pascal Henry

    2015-01-01

    In France, the building sector is the largest consumer of energy and accounts for about 43% of the total energy consumption and 25% of the CO2 emissions. In this study, we present a recently developed insulating rendering based on silica-aerogels. It is mainly developed for exterior thermal insulation applications. In addition to new buildings, it can be used for retrofitting existing ones since it has a high insulation performance and its application is compatible with the traditional masonr...

  9. European Climate - Energy Security Nexus. A model based scenario analysis

    International Nuclear Information System (INIS)

    In this research, we have provided an overview of the climate-security nexus in the European sector through a model based scenario analysis with POLES model. The analysis underline that under stringent climate policies, Europe take advantage of a double dividend in its capacity to develop a new cleaner energy model and in lower vulnerability to potential shocks on the international energy markets. (authors)

  10. Magnetron based high energy S-band linac system

    International Nuclear Information System (INIS)

    This paper deals with the study of magnetron based high energy S-band linear accelerator (linac) system operating at spot frequency 2.998 GHz. The energy and dose are two important parameters of linac system which depend on input power of microwave source and length of linac tube. Here the author has studied how these parameters can be improved for side coupled standing wave S-band linac system

  11. Metamaterials-based enhanced energy harvesting: A review

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Zhongsheng, E-mail: czs_study@sina.com; Guo, Bin; Yang, Yongmin; Cheng, Congcong

    2014-04-01

    Advances in low power design open the possibility to harvest ambient energies to power directly the electronics or recharge a secondary battery. The key parameter of an energy harvesting (EH) device is its efficiency, which strongly depends on the conversion medium. To address this issue, metamaterials, artificial materials and structures with exotic properties, have been introduced for EH in recent years. They possess unique properties not easily achieved using naturally occurring materials, such as negative stiffness, mass, Poisson's ratio, and refractive index. The goal of this paper is to review the fundamentals, recent progresses and future directions in the field of metamaterials-based enhanced energy harvesting. An introduction on EH followed by the classification of potential metamaterials for EH is presented. A number of theoretical and experimental studies on metamaterials-based EH are outlined, including phononic crystals, acoustic metamaterials, and electromagnetic metamaterials. Finally, we give an outlook on future directions of metamaterials-based energy harvesting research including but not limited to active metamaterials-based EH, metamaterials-based thermal EH, and metamaterials-based multifunctional EH capabilities.

  12. Metamaterials-based enhanced energy harvesting: A review

    International Nuclear Information System (INIS)

    Advances in low power design open the possibility to harvest ambient energies to power directly the electronics or recharge a secondary battery. The key parameter of an energy harvesting (EH) device is its efficiency, which strongly depends on the conversion medium. To address this issue, metamaterials, artificial materials and structures with exotic properties, have been introduced for EH in recent years. They possess unique properties not easily achieved using naturally occurring materials, such as negative stiffness, mass, Poisson's ratio, and refractive index. The goal of this paper is to review the fundamentals, recent progresses and future directions in the field of metamaterials-based enhanced energy harvesting. An introduction on EH followed by the classification of potential metamaterials for EH is presented. A number of theoretical and experimental studies on metamaterials-based EH are outlined, including phononic crystals, acoustic metamaterials, and electromagnetic metamaterials. Finally, we give an outlook on future directions of metamaterials-based energy harvesting research including but not limited to active metamaterials-based EH, metamaterials-based thermal EH, and metamaterials-based multifunctional EH capabilities.

  13. A New Hybrid Bathroom System Based on Energy Saving Concept

    Directory of Open Access Journals (Sweden)

    Cui Bo-wen

    2016-01-01

    Full Text Available Based on the characteristics of hot water supply in bathroom, this article proposes a new hybrid energy hot water supply system. The programmable logic controller(PLC as the master controller was adopted in this system, which could automatically detect and storage main thermal physical of the system, such as temperature, water level, solar radiation intensity, power consumption and so on. The active thermal utilization technology of solar energy, air-source heat pump technology, solar energy intensive natural ventilation technology and low temperature hot water floor radiant heating technology were organically integrated in this system, which has the advantages of energy conservation and environment protection, high automation, safe and reliable operation, etc. At the same time, it can make good use of electric power cost between on-peak and off-peak, and promote the optimal allocation of power resources and reduce the cost, which can achieve the goal of intelligent control and energy saving.

  14. Graphene-Based Integrated Photovoltaic Energy Harvesting/Storage Device.

    Science.gov (United States)

    Chien, Chih-Tao; Hiralal, Pritesh; Wang, Di-Yan; Huang, I-Sheng; Chen, Chia-Chun; Chen, Chun-Wei; Amaratunga, Gehan A J

    2015-06-24

    Energy scavenging has become a fundamental part of ubiquitous sensor networks. Of all the scavenging technologies, solar has the highest power density available. However, the energy source is erratic. Integrating energy conversion and storage devices is a viable route to obtain self-powered electronic systems which have long-term maintenance-free operation. In this work, we demonstrate an integrated-power-sheet, consisting of a string of series connected organic photovoltaic cells (OPCs) and graphene supercapacitors on a single substrate, using graphene as a common platform. This results in lighter and more flexible power packs. Graphene is used in different forms and qualities for different functions. Chemical vapor deposition grown high quality graphene is used as a transparent conductor, while solution exfoliated graphene pastes are used as supercapacitor electrodes. Solution-based coating techniques are used to deposit the separate components onto a single substrate, making the process compatible with roll-to-roll manufacture. Eight series connected OPCs based on poly(3-hexylthiophene)(P3HT):phenyl-C61-butyric acid methyl ester (PC60 BM) bulk-heterojunction cells with aluminum electrodes, resulting in a ≈5 V open-circuit voltage, provide the energy harvesting capability. Supercapacitors based on graphene ink with ≈2.5 mF cm(-2) capacitance provide the energy storage capability. The integrated-power-sheet with photovoltaic (PV) energy harvesting and storage functions had a mass of 0.35 g plus the substrate. PMID:25703342

  15. Energy savings in mobile broadband network based on load predictions

    DEFF Research Database (Denmark)

    Samulevicius, Saulius; Pedersen, Torben Bach; Sørensen, Troels Bundgaard;

    2012-01-01

    wireless networks. To save energy in MBNs, one of the options is to turn off parts of the network equipment in areas where traffic falls below a specific predefined threshold. This paper looks at a methodology for identifying periods of the day when cells or sites carrying low traffic are candidates for...... being totally or partly switched off, given that the decrease in service quality can be controlled gracefully when the sites are switched off. Based on traffic data from an operational network, potential average energy savings of approximately 30% with some few low traffic cells/sites reaching up to 99......% energy savings can be identified....

  16. Energy based Efficient Resource Scheduling in Green Computing

    Directory of Open Access Journals (Sweden)

    B.Vasumathi,

    2015-11-01

    Full Text Available Cloud Computing is an evolving area of efficient utilization of computing resources. Data centers accommodating Cloud applications ingest massive quantities of energy, contributing to high functioning expenditures and carbon footprints to the atmosphere. Hence, Green Cloud computing resolutions are required not only to save energy for the environment but also to decrease operating charges. In this paper, we emphasis on the development of energy based resource scheduling framework and present an algorithm that consider the synergy between various data center infrastructures (i.e., software, hardware, etc., and performance. In specific, this paper proposes (a architectural principles for energy efficient management of Clouds; (b energy efficient resource allocation strategies and scheduling algorithm considering Quality of Service (QoS outlooks. The performance of the proposed algorithm has been evaluated with the existing energy based scheduling algorithms. The experimental results demonstrate that this approach is effective in minimizing the cost and energy consumption of Cloud applications thus moving towards the achievement of Green Clouds.

  17. Prevalence of swallowing and speech problems in daily life after chemoradiation for head and neck cancer based on cut-off scores of the patient-reported outcome measures SWAL-QOL and SHI.

    Science.gov (United States)

    Rinkel, Rico N; Verdonck-de Leeuw, Irma M; Doornaert, Patricia; Buter, Jan; de Bree, Remco; Langendijk, Johannes A; Aaronson, Neil K; Leemans, C René

    2016-07-01

    The objective of this study is to assess swallowing and speech outcome after chemoradiation therapy for head and neck cancer, based on the patient-reported outcome measures Swallowing Quality of Life Questionnaire (SWAL-QOL) and Speech Handicap Index (SHI), both provided with cut-off scores. This is a cross-sectional study. Department of Otolaryngology/Head and Neck Surgery of a University Medical Center. Sixty patients, 6 months to 5 years after chemoradiation for head and neck squamous cell carcinoma. Swallowing Quality of Life Questionnaire (SWAL-QOL) and SHI, both validated in Dutch and provided with cut-off scores. Associations were tested between the outcome measures and independent variables (age, gender, tumor stage and site, and radiotherapy technique, time since treatment, comorbidity and food intake). Fifty-two patients returned the SWAL-QOL and 47 the SHI (response rate 87 and 78 %, respectively). Swallowing and speech problems were present in 79 and 55 %, respectively. Normal food intake was noticed in 45, 35 % had a soft diet and 20 % tube feeding. Patients with soft diet and tube feeding reported more swallowing problems compared to patients with normal oral intake. Tumor subsite was significantly associated with swallowing outcome (less problems in larynx/hypopharynx compared to oral/oropharynx). Radiation technique was significantly associated with psychosocial speech problems (less problems in patients treated with IMRT). Swallowing and (to a lesser extent) speech problems in daily life are frequently present after chemoradiation therapy for head and neck cancer. Future prospective studies will give more insight into the course of speech and swallowing problems after chemoradiation and into efficacy of new radiation techniques and swallowing and speech rehabilitation programs. PMID:26071622

  18. Cooperative relay-based multicasting for energy and delay minimization

    KAUST Repository

    Atat, Rachad

    2012-08-01

    Relay-based multicasting for the purpose of cooperative content distribution is studied. Optimized relay selection is performed with the objective of minimizing the energy consumption or the content distribution delay within a cluster of cooperating mobiles. Two schemes are investigated. The first consists of the BS sending the data only to the relay, and the second scheme considers the scenario of threshold-based multicasting by the BS, where a relay is selected to transmit the data to the mobiles that were not able to receive the multicast data. Both schemes show significant superiority compared to the non-cooperative scenarios, in terms of energy consumption and delay reduction. © 2012 IEEE.

  19. Net Balanced Floorplanning Based on Elastic Energy Model

    DEFF Research Database (Denmark)

    Liu, Wei; Nannarelli, Alberto

    2008-01-01

    balanced net delays to increase the safety margins of the design. In this paper, we investigate the properties of floorplanning based on the elastic energy model. The B*-tree, which is based on an ordered binary tree, is used for circuit representation and the elastic energy is used as the cost function....... To evaluate how well a net is balanced, we introduced a new metric 'unbalancing'. A more balanced net would have a smaller 'unbalancing' value. Experimental results show that our approach can not only meet fixed-outline constraints, but also achieve significant improvements in net balance for all the...

  20. Reliability-Based Structural Optimization of Wave Energy Converters

    DEFF Research Database (Denmark)

    Ambühl, Simon; Kramer, Morten; Sørensen, John Dalsgaard

    2014-01-01

    More and more wave energy converter (WEC) concepts are reaching prototype level. Once the prototype level is reached, the next step in order to further decrease the levelized cost of energy (LCOE) is optimizing the overall system with a focus on structural and maintenance (inspection) costs, as...... well as on the harvested power from the waves. The target of a fully-developed WEC technology is not maximizing its power output, but minimizing the resulting LCOE. This paper presents a methodology to optimize the structural design of WECs based on a reliability-based optimization problem and the...

  1. Agent-based modelling of consumer energy choices

    Science.gov (United States)

    Rai, Varun; Henry, Adam Douglas

    2016-06-01

    Strategies to mitigate global climate change should be grounded in a rigorous understanding of energy systems, particularly the factors that drive energy demand. Agent-based modelling (ABM) is a powerful tool for representing the complexities of energy demand, such as social interactions and spatial constraints. Unlike other approaches for modelling energy demand, ABM is not limited to studying perfectly rational agents or to abstracting micro details into system-level equations. Instead, ABM provides the ability to represent behaviours of energy consumers -- such as individual households -- using a range of theories, and to examine how the interaction of heterogeneous agents at the micro-level produces macro outcomes of importance to the global climate, such as the adoption of low-carbon behaviours and technologies over space and time. We provide an overview of ABM work in the area of consumer energy choices, with a focus on identifying specific ways in which ABM can improve understanding of both fundamental scientific and applied aspects of the demand side of energy to aid the design of better policies and programmes. Future research needs for improving the practice of ABM to better understand energy demand are also discussed.

  2. Writable electrochemical energy source based on graphene oxide

    Science.gov (United States)

    Wei, Di

    2015-10-01

    Graphene oxide (GO) was mainly used as raw material for various types of reduced graphene oxide (rGO) as a cost effective method to make graphene like materials. However, applications of its own unique properties such as extraordinary proton conductivity and super-permeability to water were overlooked. Here GO based battery-like planar energy source was demonstrated on arbitrary insulating substrate (e.g. polymer sheet/paper) by coating PEDOT, GO ink and rGO on Ag charge collectors. Energy from such GO battery depends on its length and one unit cell with length of 0.5 cm can generate energy capacity of 30 Ah/L with voltage up to 0.7 V when room temperature ionic liquid (RTIL) is added. With power density up to 0.4 W/cm3 and energy density of 4 Wh/L, GO battery was demonstrated to drive an electrochromic device. This work is the first attempt to generate decent energy using the fast transported water molecules inside GO. It provides very safe energy source that enables new applications otherwise traditional battery technology can not make including building a foldable energy source on paper and platform for futuristic wearable electronics. A disposable energy source made of GO was also written on a plastic glove to demonstrate wearability.

  3. A molecularly based theory for electron transfer reorganization energy

    International Nuclear Information System (INIS)

    Using field-theoretic techniques, we develop a molecularly based dipolar self-consistent-field theory (DSCFT) for charge solvation in pure solvents under equilibrium and nonequilibrium conditions and apply it to the reorganization energy of electron transfer reactions. The DSCFT uses a set of molecular parameters, such as the solvent molecule’s permanent dipole moment and polarizability, thus avoiding approximations that are inherent in treating the solvent as a linear dielectric medium. A simple, analytical expression for the free energy is obtained in terms of the equilibrium and nonequilibrium electrostatic potential profiles and electric susceptibilities, which are obtained by solving a set of self-consistent equations. With no adjustable parameters, the DSCFT predicts activation energies and reorganization energies in good agreement with previous experiments and calculations for the electron transfer between metallic ions. Because the DSCFT is able to describe the properties of the solvent in the immediate vicinity of the charges, it is unnecessary to distinguish between the inner-sphere and outer-sphere solvent molecules in the calculation of the reorganization energy as in previous work. Furthermore, examining the nonequilibrium free energy surfaces of electron transfer, we find that the nonequilibrium free energy is well approximated by a double parabola for self-exchange reactions, but the curvature of the nonequilibrium free energy surface depends on the charges of the electron-transferring species, contrary to the prediction by the linear dielectric theory

  4. Energy consumption quota of public buildings based on statistical analysis

    International Nuclear Information System (INIS)

    The establishment of building energy consumption quota as a comprehensive indicator used to evaluate the actual energy consumption level is an important measure for promoting the development of building energy efficiency. This paper focused on the determination method of the quota, and firstly introduced the procedure of establishing energy consumption quota of public buildings including four important parts: collecting data, classifying and calculating EUIs, standardizing EUIs, determining the measure method of central tendency. The paper also illustrated the standardization process of EUI by actual calculation based on the samples of 10 commercial buildings and 19 hotel buildings. According to the analysis of the frequency distribution of standardized EUIs of sample buildings and combining the characteristics of each measure method of central tendency, comprehensive application of mode and percentage rank is selected to be the best method for determining the energy consumption quota of public buildings. Finally the paper gave some policy proposals on energy consumption quota to help achieve the goal of further energy conservation. - Highlights: ► We introduce the procedure of determining energy consumption quota (ECQ). ► We illustrate the standardization process of EUI by actual calculation of samples. ► Measures of central tendency are brought into determine the ECQ. ► Comprehensive application of mode and percentage rank is the best method for ECQ. ► Punitive or incentive measures for ECQ are proposed.

  5. Energy-Based Voronoi Partition in Constant Flow Environments

    CERN Document Server

    Ru, Yu

    2011-01-01

    As is well known, energy cost can greatly impact the deployment of battery-powered sensor networks in remote environments such as rivers or oceans. Motivated by this, we propose here an energy-based metric and associate energy-based Voronoi partitions with mobile vehicles in constant flows. The metric corresponds to the minimum energy that a vehicle requires to move from one point to another in the flow environment, and the resulting partition can be used by the vehicles in cooperative control tasks such as task assignment and coverage. Based on disk-based and asymptote-based approximations of the Voronoi regions, we determine a subset (or lower bound) and superset (or upper bound) of an agent's Voronoi neighbors. We then show that, via simulations, the upper bound is tight and its cardinality remains bounded as the number of generators increases. Finally, we propose efficient algorithms to compute the upper bound (especially when the generators dynamically change), which enables the fast calculation of Voron...

  6. Energy Storage System Based on Cascaded Multilevel Inverter with Decoupled Energy Balancing Control

    Directory of Open Access Journals (Sweden)

    Cao Yuanzhi

    2015-01-01

    Full Text Available This paper presents a three phase cascaded multilevel inverter based supercapacitor (SC energy storage system with novel structure and control strategy to maintain the energy balance of between phases. Every two phases are coupled with a series LC filter. With the filter, SC cells in different phases could exchange energy with an auxiliary power flow at high frequency. The auxiliary power flow is orthogonal to the primary power flow. The phase difference between high frequency voltage and current components of each phase determines whether the energy is absorbed into or released from its SC cells. Unlike traditional energy balancing strategies, the proposed method is independent to the fundamental real power drawn by the energy storage system. Simulation results confirmed the effects of proposed theories.

  7. Prognostic scores in brain metastases from breast cancer

    Directory of Open Access Journals (Sweden)

    Astner Sabrina T

    2009-04-01

    of a consensus score for broad clinical application. The model that is based on the authors own patient group, which is not large enough to fully evaluate a large number of potential prognostic factors, is meant to illustrate this point rather than to provide the definitive score.

  8. High energy sodium based room temperature flow batteries

    Science.gov (United States)

    Shamie, Jack

    As novel energy sources such as solar, wind and tidal energies are explored it becomes necessary to build energy storage facilities to load level the intermittent nature of these energy sources. Energy storage is achieved by converting electrical energy into another form of energy. Batteries have many properties that are attractive for energy storage including high energy and power. Among many different types of batteries, redox flow batteries (RFBs) offer many advantages. Unlike conventional batteries, RFBs store energy in a liquid medium rather than solid active materials. This method of storage allows for the separation of energy and power unlike conventional batteries. Additionally flow batteries may have long lifetimes because there is no expansion or contraction of electrodes. A major disadvantage of RFB's is its lower energy density when compared to traditional batteries. In this Thesis, a novel hybrid Na-based redox flow battery (HNFB) is explored, which utilizes a room temperature molten sodium based anode, a sodium ion conducting solid electrolyte and liquid catholytes. The sodium electrode leads to high voltages and energy and allows for the possibility of multi-electron transfer per molecule. Vanadium acetylacetonate (acac) and TEMPO have been investigated for their use as catholytes. In the vanadium system, 2 electrons transfers per vanadium atom were found leading to a doubling of capacity. In addition, degradation of the charged state was found to be reversible within the voltage range of the cell. Contamination by water leads to the formation of vanadyl acetylacetonate. Although it is believed that vanadyl complex need to be taken to low voltages to be reduced back to vanadium acac, a new mechanism is shown that begins at higher voltages (2.1V). Vanadyl complexes react with excess ligand and protons to reform the vanadium complex. During this reaction, water is reformed leading to the continuous cycle in which vanadyl is formed and then reduced back

  9. Modelling the predictive performance of credit scoring

    Directory of Open Access Journals (Sweden)

    Shi-Wei Shen

    2013-02-01

    Full Text Available Orientation: The article discussed the importance of rigour in credit risk assessment.Research purpose: The purpose of this empirical paper was to examine the predictive performance of credit scoring systems in Taiwan.Motivation for the study: Corporate lending remains a major business line for financial institutions. However, in light of the recent global financial crises, it has become extremely important for financial institutions to implement rigorous means of assessing clients seeking access to credit facilities.Research design, approach and method: Using a data sample of 10 349 observations drawn between 1992 and 2010, logistic regression models were utilised to examine the predictive performance of credit scoring systems.Main findings: A test of Goodness of fit demonstrated that credit scoring models that incorporated the Taiwan Corporate Credit Risk Index (TCRI, micro- and also macroeconomic variables possessed greater predictive power. This suggests that macroeconomic variables do have explanatory power for default credit risk.Practical/managerial implications: The originality in the study was that three models were developed to predict corporate firms’ defaults based on different microeconomic and macroeconomic factors such as the TCRI, asset growth rates, stock index and gross domestic product.Contribution/value-add: The study utilises different goodness of fits and receiver operator characteristics during the examination of the robustness of the predictive power of these factors.

  10. Enhanced vibration based energy harvesting using embedded acoustic black holes

    Science.gov (United States)

    Zhao, L.; Semperlotti, F.; Conlon, S. C.

    2014-03-01

    In this paper, we investigate the use of dynamic structural tailoring via the concept of an Acoustic Black Hole (ABH) to enhance the performance of piezoelectric based energy harvesting from operational mechanical vibrations. The ABH is a variable thickness structural feature that can be embedded in the host structure allowing a smooth reduction of the phase velocity while minimizing the amplitude of reflected waves. The ABH thickness variation is typically designed according to power-law profiles. As a propagating wave enters the ABH, it is progressively slowed down while its wavelength is compressed. This effect results in structural areas with high energy density that can be exploited effectively for energy harvesting. The potential of ABH for energy harvesting is shown via a numerical study based on fully coupled finite element electromechanical models of an ABH tapered plate with surface mounted piezo-transducers. The performances of the novel design are evaluated by direct comparison with a non-tapered structure in terms of energy ratios and attenuation indices. Results show that the tailored structural design allows a drastic increase in the harvested energy both for steady state and transient excitation. Performance dependencies of key design parameters are also investigated.

  11. Distributed energy resources at naval base ventura county building 1512

    International Nuclear Information System (INIS)

    This paper reports the findings of a preliminary assessment of the cost effectiveness of distributed energy resources at Naval Base Ventura County (NBVC) Building 1512. This study was conducted in response to the base's request for design assistance to the Federal Energy Management Program. Given the current tariff structure there are two main decisions facing NBVC: whether to install distributed energy resources (DER), or whether to continue the direct access energy supply contract. At the current effective rate, given assumptions about the performance and structure of building energy loads and available generating technology characteristics, the results of this study indicate that if the building installed a 600 kW DER system with absorption cooling and heat capabilities chosen by cost minimization, the energy cost savings would be about 14 percent, or $55,000 per year. However, under current conditions, this study also suggests that significant savings could be obtained if Building 1 512 changed from the direct access contract to a SCE TOU-8 (Southern California Edison time of use tariff number 8) rate without installing a DER system. At current SCE TOU-8 tariffs, the potential savings from installation of a DER system would be about 4 percent, or $15,000 per year

  12. FUZZY LOGIC BASED ENERGY EFFICIENT PROTOCOL IN WIRELESS SENSOR NETWORKS

    Directory of Open Access Journals (Sweden)

    Zhan Wei Siew

    2012-12-01

    Full Text Available Wireless sensor networks (WSNs have been vastly developed due to the advances in microelectromechanical systems (MEMS using WSN to study and monitor the environments towards climates changes. In environmental monitoring, sensors are randomly deployed over the interest area to periodically sense the physical environments for a few months or even a year. Therefore, to prolong the network lifetime with limited battery capacity becomes a challenging issue. Low energy adaptive cluster hierarchical (LEACH is the common clustering protocol that aim to reduce the energy consumption by rotating the heavy workload cluster heads (CHs. The CHs election in LEACH is based on probability model which will lead to inefficient in energy consumption due to least desired CHs location in the network. In WSNs, the CHs location can directly influence the network energy consumption and further affect the network lifetime. In this paper, factors which will affect the network lifetime will be presented and the demonstration of fuzzy logic based CH selection conducted in base station (BS will also be carried out. To select suitable CHs that will prolong the network first node dies (FND round and consistent throughput to the BS, energy level and distance to the BS are selected as fuzzy inputs.

  13. Biomass-based energy carriers in the transportation sector

    International Nuclear Information System (INIS)

    The purpose of this report is to study the technical and economic prerequisites to attain reduced carbon dioxide emissions through the use of biomass-based energy carriers in the transportation sector, and to study other environmental impacts resulting from an increased use of biomass-based energy carriers. CO2 emission reduction per unit arable and forest land used for biomass production (kg CO2/ha,year) and costs for CO2 emission reduction (SEK/kg CO2) are estimated for the substitution of gasoline and diesel with rape methyl ester, biogas from lucerne, ethanol from wheat and ethanol, methanol, hydrogen and electricity from Salix and logging residues. Of the studied energy carriers, those based on Salix provide the largest CO2 emission reduction. In a medium long perspective, the costs for CO2 emission reduction seem to be lowest for methanol from Salix and logging residues. The use of fuel cell vehicles, using methanol or hydrogen as energy carriers, can in a longer perspective provide more energy efficient utilization of biomass for transportation than the use of internal combustion engine vehicles. 136 refs, 12 figs, 25 tabs

  14. Interpreting force concept inventory scores: Normalized gain and SAT scores

    Directory of Open Access Journals (Sweden)

    Jeffrey J. Steinert

    2007-05-01

    Full Text Available Preinstruction SAT scores and normalized gains (G on the force concept inventory (FCI were examined for individual students in interactive engagement (IE courses in introductory mechanics at one high school (N=335 and one university (N=292 , and strong, positive correlations were found for both populations ( r=0.57 and r=0.46 , respectively. These correlations are likely due to the importance of cognitive skills and abstract reasoning in learning physics. The larger correlation coefficient for the high school population may be a result of the much shorter time interval between taking the SAT and studying mechanics, because the SAT may provide a more current measure of abilities when high school students begin the study of mechanics than it does for college students, who begin mechanics years after the test is taken. In prior research a strong correlation between FCI G and scores on Lawson’s Classroom Test of Scientific Reasoning for students from the same two schools was observed. Our results suggest that, when interpreting class average normalized FCI gains and comparing different classes, it is important to take into account the variation of students’ cognitive skills, as measured either by the SAT or by Lawson’s test. While Lawson’s test is not commonly given to students in most introductory mechanics courses, SAT scores provide a readily available alternative means of taking account of students’ reasoning abilities. Knowing the students’ cognitive level before instruction also allows one to alter instruction or to use an intervention designed to improve students’ cognitive level.

  15. Interpreting force concept inventory scores: Normalized gain and SAT scores

    Science.gov (United States)

    Coletta, Vincent P.; Phillips, Jeffrey A.; Steinert, Jeffrey J.

    2007-06-01

    Preinstruction SAT scores and normalized gains (G) on the force concept inventory (FCI) were examined for individual students in interactive engagement (IE) courses in introductory mechanics at one high school (N=335) and one university (N=292) , and strong, positive correlations were found for both populations ( r=0.57 and r=0.46 , respectively). These correlations are likely due to the importance of cognitive skills and abstract reasoning in learning physics. The larger correlation coefficient for the high school population may be a result of the much shorter time interval between taking the SAT and studying mechanics, because the SAT may provide a more current measure of abilities when high school students begin the study of mechanics than it does for college students, who begin mechanics years after the test is taken. In prior research a strong correlation between FCI G and scores on Lawson’s Classroom Test of Scientific Reasoning for students from the same two schools was observed. Our results suggest that, when interpreting class average normalized FCI gains and comparing different classes, it is important to take into account the variation of students’ cognitive skills, as measured either by the SAT or by Lawson’s test. While Lawson’s test is not commonly given to students in most introductory mechanics courses, SAT scores provide a readily available alternative means of taking account of students’ reasoning abilities. Knowing the students’ cognitive level before instruction also allows one to alter instruction or to use an intervention designed to improve students’ cognitive level.

  16. The HEART score for chest pain patients

    NARCIS (Netherlands)

    Backus, B.E.

    2012-01-01

    The HEART score was developed to improve risk stratification in chest pain patients in the emergency department (ED). This thesis describes series of validation studies of the HEART score and sub studies for individual elements of the score. The predictive value of the HEART score for the occurrence

  17. FEL based photon collider of TeV energy range

    International Nuclear Information System (INIS)

    Physical principles of operation of high energy photon linear colliders (PLC) based on the Compton backscattering of laser photons on high energy electrons are discussed. The main emphasis is put on the analysis of a possibility to construct the PLC with the center of mass energy 0.5-2 TeV. Free electron laser (FEL) is considered as a source of primary photons. Proposed FEL system consists of a tunable FEL oscillator (output power ∼ 1 - 10 MW) with subsequent amplification of the master signal in a FEL amplifier up to the power ∼ 3 x 1011 W. The FEL parameters are optimized, restrictions on the electron beam and FEL magnetic system parameters are formulated and problems of technical realization are discussed. It is shown that the FEL technique provides the most suitable way to construct photon linear collider on the base of future generation linear collider. 22 refs., 10 figs., 2 tabs

  18. Geothermal energy in Idaho: site data base and development status

    Energy Technology Data Exchange (ETDEWEB)

    McClain, D.W.

    1979-07-01

    Detailed site specific data regarding the commercialization potential of the proven, potential, and inferred geothermal resource areas in Idaho are presented. To assess the potential for geothermal resource development in Idaho, several kinds of data were obtained. These include information regarding institutional procedures for geothermal development, logistical procedures for utilization, energy needs and forecasted demands, and resource data. Area reports, data sheets, and scenarios were prepared that described possible geothermal development at individual sites. In preparing development projections, the objective was to base them on actual market potential, forecasted growth, and known or inferred resource conditions. To the extent possible, power-on-line dates and energy utilization estimates are realistic projections of the first events. Commercialization projections were based on the assumption that an aggressive development program will prove sufficient known and inferred resources to accomplish the projected event. This report is an estimate of probable energy developable under an aggressive exploration program and is considered extremely conservative. (MHR)

  19. Prediction of true test scores from observed item scores and ancillary data.

    Science.gov (United States)

    Haberman, Shelby J; Yao, Lili; Sinharay, Sandip

    2015-05-01

    In many educational tests which involve constructed responses, a traditional test score is obtained by adding together item scores obtained through holistic scoring by trained human raters. For example, this practice was used until 2008 in the case of GRE(®) General Analytical Writing and until 2009 in the case of TOEFL(®) iBT Writing. With use of natural language processing, it is possible to obtain additional information concerning item responses from computer programs such as e-rater(®). In addition, available information relevant to examinee performance may include scores on related tests. We suggest application of standard results from classical test theory to the available data to obtain best linear predictors of true traditional test scores. In performing such analysis, we require estimation of variances and covariances of measurement errors, a task which can be quite difficult in the case of tests with limited numbers of items and with multiple measurements per item. As a consequence, a new estimation method is suggested based on samples of examinees who have taken an assessment more than once. Such samples are typically not random samples of the general population of examinees, so that we apply statistical adjustment methods to obtain the needed estimated variances and covariances of measurement errors. To examine practical implications of the suggested methods of analysis, applications are made to GRE General Analytical Writing and TOEFL iBT Writing. Results obtained indicate that substantial improvements are possible both in terms of reliability of scoring and in terms of assessment reliability. PMID:25773314

  20. Renewable Energy for Electric Vehicles: Price Based Charging Coordination

    NARCIS (Netherlands)

    Richstein, J.C.; Schuller, A.; Dinther, C.; Ketter, W.; Weinhardt, C.

    2012-01-01

    In this paper we investigate the charging coordination of battery electric vehicles (BEV) with respect to the availability of intermittent renewable energy generation considering individual real world driving profiles in a deterministic simulation based analysis, mapping a part of the German power s