WorldWideScience

Sample records for barrier system selection

  1. Protection against malevolent use of vehicles at Nuclear Power Plants. Vehicle barrier system selection guidance

    Energy Technology Data Exchange (ETDEWEB)

    Nebuda, D.T.

    1994-08-01

    This manual provides a simplified procedure for selecting land vehicle barriers that will stop the design basis vehicle threat adopted by the U.S. Nuclear Regulatory Commission. Proper selection and construction of vehicle barriers should prevent intrusion of the design basis vehicle. In addition, vital safety related equipment should survive a design basis vehicle bomb attack when vehicle barriers are properly selected, sited, and constructed. This manual addresses passive vehicle barriers, active vehicle barriers, and site design features that can be used to reduce vehicle impact velocity.

  2. Advanced thermal barrier coating systems

    Science.gov (United States)

    Dorfman, M. R.; Reardon, J. D.

    1985-01-01

    Current state-of-the-art thermal barrier coating (TBC) systems consist of partially stabilized zirconia coatings plasma sprayed over a MCrAlY bond coat. Although these systems have excellent thermal shock properties, they have shown themselves to be deficient for a number of diesel and aircraft applications. Two ternary ceramic plasma coatings are discussed with respect to their possible use in TBC systems. Zirconia-ceria-yttria (ZCY) coatings were developed with low thermal conductivities, good thermal shock resistance and improved resistance to vanadium containing environments, when compared to the baseline yttria stabilized zirconia (YSZ) coatings. In addition, dense zirconia-titania-yttria (ZTY) coatings were developed with particle erosion resistance exceeding conventional stabilized zirconia coatings. Both coatings were evaluated in conjunction with a NiCr-Al-Co-Y2O3 bond coat. Also, multilayer or hybrid coatings consisting of the bond coat with subsequent coatings of zirconia-ceria-yttria and zirconia-titania-yttria were evaluated. These coatings combine the enhanced performance characteristics of ZCY with the improved erosion resistance of ZTY coatings. Improvement in the erosion resistance of the TBC system should result in a more consistent delta T gradient during service. Economically, this may also translate into increased component life simply because the coating lasts longer.

  3. Autostereoscopic display concept with time-sequential wavelength-selective filter-barrier

    Science.gov (United States)

    Jurk, Silvio; Kuhlmey, Mathias; Bartmann, Roland; Duckstein, Bernd; de la Barré, René

    2016-03-01

    A spatially multiplexed autostereoscopic 3D display design with a strip barrier consisting of RGB-color filters is presented. The wavelength selective filter barrier emits the light from a display area larger than that of common autostereoscopic barrier displays. However, such construction is still used rather rarely. The time sequential operation mode is a supplemental option. Wavelength selective filter barrier arrangements exhibit characteristics different from common barrier displays with similar barrier pitch and ascent. In particular these constructions show strong angular luminance dependency under barrier inclination specified by correspondent slant angle. In time sequential implementation it is important to avoid that quick eye or eyelid movement lead to visible color artifacts. Those circumstances limit the possibility to find well working and usable display designs superior to usual barrier displays. The newly introduced design is usable as a multi user display as well as a single user system with user adaptive control. In case of tracked single user mode the adaption in x-z-direction is continuously. The design has been modelled with simulation software developed for that purpose. The modelling of wavelength-selective barriers was used to calculate the light ray distribution properties of that arrangement. For the experimental verification of the image separation and evaluation of image quality, commercially available display components were combined for a display demonstrator.

  4. Systems study on engineered barriers: barrier performance analysis

    Energy Technology Data Exchange (ETDEWEB)

    Stula, R.T.; Albert, T.E.; Kirstein, B.E.; Lester, D.H.

    1980-09-01

    A performance assessment model for multiple barrier packages containing unreprocessed spent fuel has been modified and applied to several package designs. The objective of the study was to develop information to be used in programmatic decision making concerning engineered barrier package design and development. The assessment model, BARIER, was developed in previous tasks of the System Study on Engineered Barriers (SSEB). The new version discussed in this report contains a refined and expanded corrosion rate data base which includes pitting, crack growth, and graphitization as well as bulk corrosion. Corrosion rates for oxic and anoxic conditions at each of the two temperature ranges are supplied. Other improvements include a rigorous treatment of radionuclide release after package failure which includes resistance of damaged barriers and backfill, refined temperature calculations that account for convection and radiation, a subroutine to calculate nuclear gamma radiation field at each barrier surface, refined stress calculations with reduced conservatism and various coding improvements to improve running time and core usage. This report also contains discussion of alternative scenarios to the assumed flooded repository as well as the impact of water exclusion backfills. The model was used to assess post repository closure performance for several designs which were all variation of basic designs from the Spent Unreprocessed Fuel (SURF) program. Many designs were found to delay the onset of leaching by at least a few hundreds of years in all geologic media. Long delay times for radionuclide release were found for packages with a few inches of sorption backfill. Release of uranium, plutonium, and americium was assessed.

  5. Brain barrier systems: a new frontier in metal neurotoxicological research

    OpenAIRE

    Zheng, Wei; Aschner, Michael; Ghersi-Egea, Jean-Francois

    2003-01-01

    The concept of brain barriers or a brain barrier system embraces the blood–brain interface, referred to as the blood–brain barrier, and the blood–cerebrospinal fluid (CSF) interface, referred to as the blood–CSF barrier. These brain barriers protect the CNS against chemical insults, by different complementary mechanisms. Toxic metal molecules can either bypass these mechanisms or be sequestered in and therefore potentially deleterious to brain barriers. Supportive evidence suggests that damag...

  6. SELECTION OF OXIDES FOR STABILIZATION OF ZIRCONIUM DIOXIDE WHILE OBTAINING THERMAL BARRIER COATINGS

    Directory of Open Access Journals (Sweden)

    V. V. Okovity

    2015-01-01

    Full Text Available The paper analyzes selection of oxides and describes in details a majority of oxide systems which are applicable for stabilization of zirconium dioxide while obtaining thermal barrier coatings with maximum amount of tetragonal phase. Methodology of investigation is based on a review of analytical information on the current state of thermal barrier coatings on the basis of zirconium dioxide stabilized by oxides of rare-earth metals. The method used for application of  zirconium dioxide thermal barrier coatings is plasma spraying. Positive results have been also obtained while applying e-beam sputtering, ion-plasma deposition and magnetron sputtering. Nevertheless preferred plasma spraying application for thermal barrier coatings still continues due to its high productivity and versatility that permits to deposit metallic and ceramic materials of the ordered chemical and phase composition.Ytterbium and cerium oxides have been selected as oxides for stabilization of zirconium dioxide in order to obtain thermal barrier coatings. The paper also considers аn oxide system of zirconium dioxide: “hafnium oxide – yttrium oxide”, representing in itself the structure which is similar to zirconium dioxide.

  7. Engineered Barrier System: Physical and Chemical Environment

    Energy Technology Data Exchange (ETDEWEB)

    P. Dixon

    2004-04-26

    The conceptual and predictive models documented in this Engineered Barrier System: Physical and Chemical Environment Model report describe the evolution of the physical and chemical conditions within the waste emplacement drifts of the repository. The modeling approaches and model output data will be used in the total system performance assessment (TSPA-LA) to assess the performance of the engineered barrier system and the waste form. These models evaluate the range of potential water compositions within the emplacement drifts, resulting from the interaction of introduced materials and minerals in dust with water seeping into the drifts and with aqueous solutions forming by deliquescence of dust (as influenced by atmospheric conditions), and from thermal-hydrological-chemical (THC) processes in the drift. These models also consider the uncertainty and variability in water chemistry inside the drift and the compositions of introduced materials within the drift. This report develops and documents a set of process- and abstraction-level models that constitute the engineered barrier system: physical and chemical environment model. Where possible, these models use information directly from other process model reports as input, which promotes integration among process models used for total system performance assessment. Specific tasks and activities of modeling the physical and chemical environment are included in the technical work plan ''Technical Work Plan for: In-Drift Geochemistry Modeling'' (BSC 2004 [DIRS 166519]). As described in the technical work plan, the development of this report is coordinated with the development of other engineered barrier system analysis model reports.

  8. ENGINEERED BARRIER SYSTEM: PHYSICAL AND CHEMICAL ENVIRONMENT

    Energy Technology Data Exchange (ETDEWEB)

    R. Jarek

    2004-11-23

    The purpose of this report is to describe the evolution of the physical and chemical environmental conditions within the waste emplacement drifts of the repository, including the drip shield and waste package surfaces. The abstraction model is used in the total system performance assessment for the license application (TSPA LA) to assess the performance of the engineered barrier system and the waste form. This report develops and documents a set of these abstraction-level models that describe the engineered barrier system physical and chemical environment. Where possible, these models use information directly from other reports as input, which promotes integration among process models used for TSPA-LA. Specific tasks and activities of modeling the physical and chemical environment are included in ''Technical Work Plan for: Near-Field Environment and Transport In-Drift Geochemistry Model Report Integration'' (BSC 2004 [DIRS 171156], Section 1.2.2). As described in the technical work plan, the development of this report is coordinated with the development of other engineered barrier system reports.

  9. ENGINEERED BARRIER SYSTEM: PHYSICAL AND CHEMICAL ENVIRONMENT

    Energy Technology Data Exchange (ETDEWEB)

    G.H. Nieder-Westermann

    2005-04-07

    The purpose of this report is to describe the evolution of the physical and chemical environmental conditions within the waste emplacement drifts of the repository, including the drip shield and waste package surfaces. The abstraction model is used in the total system performance assessment for the license application (TSPA LA) to assess the performance of the engineered barrier system and the waste form. This report develops and documents a set of these abstraction-level models that describe the engineered barrier system physical and chemical environment. Where possible, these models use information directly from other reports as input, which promotes integration among process models used for TSPA-LA. Specific tasks and activities of modeling the physical and chemical environment are included in ''Technical Work Plan for: Near-Field Environment and Transport In-Drift Geochemistry Model Report Integration'' (BSC 2004 [DIRS 171156], Section 1.2.2). As described in the technical work plan, the development of this report is coordinated with the development of other engineered barrier system reports.

  10. SUBSURFACE BARRIER VALIDATION WITH THE SEAFACE SYSTEM

    Energy Technology Data Exchange (ETDEWEB)

    Sandra Dalvit Dunn

    1997-11-30

    The overall objective of the effort was to develop and demonstrate an integrated methodology and field system to evaluate the integrity of in situ, impermeable barriers constructed in the vadose zone. An autonomous, remotely accessible, automatic monitoring and analysis system was designed and fabricated. It was thoroughly tested under field conditions, and was able to function as designed throughout the test period. Data inversion software was developed with enhanced capabilities over the previous prototype version, and integrated with the monitoring system for real time operation. Analytical simulations were performed to determine the inversion code's sensitivity to model parameters. Numerical simulations were performed to better understand how typical field conditions differ from the ideal model(s) which are used (or have been developed for use) in the inversion code and to further validate the flux limited forward model developed for use with the system. Results from the analytical and numerical assessment of the inversion code showed that the SEAtrace{trademark} approach could locate leaks within 0.4 to 1.2 m. Leak size determination was less accurate, but produced results within a factor of 3 to 8 for leaks in the 2.5 to 10 cm diameter range. The smallest engineered leak in the test 1.1 cm diameter, could be located but its size estimate was high by a factor of 30. Data analysis was performed automatically after each gas scan was completed, yielding results in less than thirty minutes, although the bulk of the results reported required post test data analysis to remove effects of high background concentrations. The field test of the integrated system was problematic, primarily due to unanticipated, unintentional leaks formed in the impermeable liner. The test facility constructed to proof the system was ambitious, initially having 11 engineered leaks of various dimensions that could be independently operated. While a great deal of care went into the

  11. Engineered Barrier System Degradation, Flow, and Transport Process Model Report

    Energy Technology Data Exchange (ETDEWEB)

    E.L. Hardin

    2000-07-17

    The Engineered Barrier System Degradation, Flow, and Transport Process Model Report (EBS PMR) is one of nine PMRs supporting the Total System Performance Assessment (TSPA) being developed by the Yucca Mountain Project for the Site Recommendation Report (SRR). The EBS PMR summarizes the development and abstraction of models for processes that govern the evolution of conditions within the emplacement drifts of a potential high-level nuclear waste repository at Yucca Mountain, Nye County, Nevada. Details of these individual models are documented in 23 supporting Analysis/Model Reports (AMRs). Nineteen of these AMRs are for process models, and the remaining 4 describe the abstraction of results for application in TSPA. The process models themselves cluster around four major topics: ''Water Distribution and Removal Model, Physical and Chemical Environment Model, Radionuclide Transport Model, and Multiscale Thermohydrologic Model''. One AMR (Engineered Barrier System-Features, Events, and Processes/Degradation Modes Analysis) summarizes the formal screening analysis used to select the Features, Events, and Processes (FEPs) included in TSPA and those excluded from further consideration. Performance of a potential Yucca Mountain high-level radioactive waste repository depends on both the natural barrier system (NBS) and the engineered barrier system (EBS) and on their interactions. Although the waste packages are generally considered as components of the EBS, the EBS as defined in the EBS PMR includes all engineered components outside the waste packages. The principal function of the EBS is to complement the geologic system in limiting the amount of water contacting nuclear waste. A number of alternatives were considered by the Project for different EBS designs that could provide better performance than the design analyzed for the Viability Assessment. The design concept selected was Enhanced Design Alternative II (EDA II).

  12. Article Including Environmental Barrier Coating System

    Science.gov (United States)

    Lee, Kang N. (Inventor)

    2015-01-01

    An enhanced environmental barrier coating for a silicon containing substrate. The enhanced barrier coating may include a bond coat doped with at least one of an alkali metal oxide and an alkali earth metal oxide. The enhanced barrier coating may include a composite mullite bond coat including BSAS and another distinct second phase oxide applied over said surface.

  13. Energy Dependence of the Fusion Barrier for Heavy Nuclear Systems

    Institute of Scientific and Technical Information of China (English)

    LIZhu-xia; WUXi-zhen; TIANJun-long; WANGNing

    2003-01-01

    The dynamical behavior of the fusion potential barrier for heavy nuclear systems is studied by means of the improved quantum molecular dynamics model. It is found that the fusion potential barrier experienced in a realistic fusion process (the dynamic fusion potential barrier) reduces with decrease of incident energies.

  14. ENGINEERED BARRIER SYSTEM: PHYSICAL AND CHEMICAL ENVIRONMENT

    Energy Technology Data Exchange (ETDEWEB)

    R. Jarek

    2005-08-29

    The purpose of this model report is to describe the evolution of the physical and chemical environmental conditions within the waste emplacement drifts of the repository, including the drip shield and waste package surfaces. The resulting seepage evaporation and gas abstraction models are used in the total system performance assessment for the license application (TSPA-LA) to assess the performance of the engineered barrier system and the waste form. This report develops and documents a set of abstraction-level models that describe the engineered barrier system physical and chemical environment. Where possible, these models use information directly from other reports as input, which promotes integration among process models used for TSPA-LA. Specific tasks and activities of modeling the physical and chemical environment are included in ''Technical Work Plan for: Near-Field Environment and Transport In-Drift Geochemistry Model Report Integration'' (BSC 2005 [DIRS 173782], Section 1.2.2). As described in the technical work plan, the development of this report is coordinated with the development of other engineered barrier system reports. To be consistent with other project documents that address features, events, and processes (FEPs), Table 6.14.1 of the current report includes updates to FEP numbers and FEP subjects for two FEPs identified in the technical work plan (TWP) governing this report (BSC 2005 [DIRS 173782]). FEP 2.1.09.06.0A (Reduction-oxidation potential in EBS), as listed in Table 2 of the TWP (BSC 2005 [DIRS 173782]), has been updated in the current report to FEP 2.1.09.06.0B (Reduction-oxidation potential in Drifts; see Table 6.14-1). FEP 2.1.09.07.0A (Reaction kinetics in EBS), as listed in Table 2 of the TWP (BSC 2005 [DIRS 173782]), has been updated in the current report to FEP 2.1.09.07.0B (Reaction kinetics in Drifts; see Table 6.14-1). These deviations from the TWP are justified because they improve integration with FEPs

  15. Applications of barrier bucket RF systems at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Bhat, C.M.; /Fermilab

    2006-03-01

    In recent years, the barrier rf systems have become important tools in a variety of beam manipulation applications at synchrotrons. Four out of six proton synchrotrons at Fermilab are equipped with broad-band barrier rf systems. All of the beam manipulations pertaining to the longitudinal phase space in the Fermilab Recycler (synchrotron used for antiproton storage) are carried out using a barrier system. Recently, a number of new applications of barrier rf systems have been developed- the longitudinal momentum mining, longitudinal phase-space coating, antiproton stacking, fast bunch compression and more. Some of these techniques have been critical for the recent spectacular success of the collider performance at the Fermilab Tevatron. Barrier bunch coalescing to produce bright proton bunches has a high potential to increase proton antiproton luminosity significantly. In this paper, I will describe some of these techniques in detail. Finally, I make a few general remarks on issues related to barrier systems.

  16. International Collaboration Activities on Engineered Barrier Systems

    Energy Technology Data Exchange (ETDEWEB)

    Jove-Colon, Carlos F. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-08-31

    The Used Fuel Disposition Campaign (UFDC) within the DOE Fuel Cycle Technologies (FCT) program has been engaging in international collaborations between repository R&D programs for high-level waste (HLW) disposal to leverage on gathered knowledge and laboratory/field data of near- and far-field processes from experiments at underground research laboratories (URL). Heater test experiments at URLs provide a unique opportunity to mimetically study the thermal effects of heat-generating nuclear waste in subsurface repository environments. Various configurations of these experiments have been carried out at various URLs according to the disposal design concepts of the hosting country repository program. The FEBEX (Full-scale Engineered Barrier Experiment in Crystalline Host Rock) project is a large-scale heater test experiment originated by the Spanish radioactive waste management agency (Empresa Nacional de Residuos Radiactivos S.A. – ENRESA) at the Grimsel Test Site (GTS) URL in Switzerland. The project was subsequently managed by CIEMAT. FEBEX-DP is a concerted effort of various international partners working on the evaluation of sensor data and characterization of samples obtained during the course of this field test and subsequent dismantling. The main purpose of these field-scale experiments is to evaluate feasibility for creation of an engineered barrier system (EBS) with a horizontal configuration according to the Spanish concept of deep geological disposal of high-level radioactive waste in crystalline rock. Another key aspect of this project is to improve the knowledge of coupled processes such as thermal-hydro-mechanical (THM) and thermal-hydro-chemical (THC) operating in the near-field environment. The focus of these is on model development and validation of predictions through model implementation in computational tools to simulate coupled THM and THC processes.

  17. Deployment Efficiency and Barrier Effectiveness Testing of a Temporary Anti-Personnel (TAP) Barrier System.

    Energy Technology Data Exchange (ETDEWEB)

    Allen, David James [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hedrick, Charles D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Martinez, Ruben [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-02-01

    This report documents tests conducted by Sandia National Laboratories (SNL) on behalf of the U.S. Department of State to evaluate a temporary anti-personnel (TAP) barrier system developed by Mitigation Technologies. For this, the SNL Denial and Structural Assessment department developed a test protocol for the evaluation of the TAP barrier system on the basis of deployment efficiency and barrier effectiveness against a riotous/mob attack threat. The test protocol was then executed by SNL personnel and the results of the testing are documented.

  18. Fluctuating Potential Barrier System with Correlated Spatial Noises

    Institute of Scientific and Technical Information of China (English)

    LI Jing-Hui

    2004-01-01

    In this paper, we study a fluctuating potential barrier system with correlated spatial noises. Study shows that for this system, there is the resonant activation over the fluctuating potential barrier, and that the correlation between the different spatial noises can enhance (or weaken) the resonant activation.

  19. Combustion chemical vapor desposited coatings for thermal barrier coating systems

    Energy Technology Data Exchange (ETDEWEB)

    Hampikian, J.M.; Carter, W.B. [Georgia Institute of Technology, Atlanta, GA (United States)

    1995-10-01

    The new deposition process, combustion chemical vapor deposition, shows a great deal of promise in the area of thermal barrier coating systems. This technique produces dense, adherent coatings, and does not require a reaction chamber. Coatings can therefore be applied in the open atmosphere. The process is potentially suitable for producing high quality CVD coatings for use as interlayers between the bond coat and thermal barrier coating, and/or as overlayers, on top of thermal barrier coatings.

  20. Functions of an engineered barrier system for a nuclear waste repository in basalt

    Energy Technology Data Exchange (ETDEWEB)

    Coons, W.E.; Moore, E.L.; Smith, M.J.; Kaser, J.D.

    1980-01-01

    Defined in this document are the functions of components selected for an engineered barrier system for a nuclear waste repository in basalt. The definitions provide a focal point for barrier material research and development by delineating the purpose and operative lifetime of each component of the engineered system. A five-component system (comprised of waste form, canister, buffer, overpack, and tailored backfill) is discussed in terms of effective operation throughout the course of repository history, recognizing that the emplacement environment changes with time. While components of the system are mutually supporting, redundancy is provided by subsystems of physical and chemical barriers which act in concert with the geology to provide a formidable barrier to transport of hazardous materials to the biosphere. The operating philosophy of the conceptual engineered barrier system is clarified by examples pertinent to storage in basalt, and a technical approach to barrier design and material selection is proposed. A method for system validation and qualification is also included which considers performance criteria proposed by external agencies in conjunction with site-specific models and risk assessment to define acceptable levels of system performance.

  1. Phonon tunneling through a double barrier system

    Energy Technology Data Exchange (ETDEWEB)

    Villegas, Diosdado [Departamento de Física, Universidad Central “Marta Abreu” de Las Villas, CP 54830, Santa Clara, Villa Clara (Cuba); Instituto de Física, Universidad Autónoma de Puebla, 18 Sur y San Claudio, Edif. 110A, Ciudad Universitaria, 72570 Puebla (Mexico); León-Pérez, Fernando de [Centro Universitario de la Defensa de Zaragoza, Ctra. de Huesca s/n, E-50090 Zaragoza (Spain); Pérez-Álvarez, R. [Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, CP 62209 Cuernavaca (Mexico); Arriaga, J., E-mail: arriaga@ifuap.buap.mx [Instituto de Física, Universidad Autónoma de Puebla, 18 Sur y San Claudio, Edif. 110A, Ciudad Universitaria, 72570 Puebla (Mexico)

    2015-04-15

    The tunneling of optical and acoustic phonons at normal incidence on a double-barrier is studied in this paper. Transmission coefficients and resonance conditions are derived theoretically under the assumption that the long-wavelength approximation is valid. It is shown that the behavior of the transmission coefficients for the symmetric double barrier has a Lorentzian form close to resonant frequencies and that Breit–Wigner's formula have a general validity in one-dimensional phonon tunneling. Authors also study the so-called generalized Hartman effect in the tunneling of long-wavelength phonons and show that this effect is a numerical artifact resulting from taking the opaque limit before exploring the variation with a finite barrier width. This study could be useful for the design of acoustic devices.

  2. ENGINEERED BARRIER SYSTEM FEATURES, EVENTS AND PROCESSES

    Energy Technology Data Exchange (ETDEWEB)

    Jaros, W.

    2005-08-30

    The purpose of this report is to evaluate and document the inclusion or exclusion of engineered barrier system (EBS) features, events, and processes (FEPs) with respect to models and analyses used to support the total system performance assessment for the license application (TSPA-LA). A screening decision, either Included or Excluded, is given for each FEP along with the technical basis for exclusion screening decisions. This information is required by the U.S. Nuclear Regulatory Commission (NRC) at 10 CFR 63.114 (d, e, and f) [DIRS 173273]. The FEPs addressed in this report deal with those features, events, and processes relevant to the EBS focusing mainly on those components and conditions exterior to the waste package and within the rock mass surrounding emplacement drifts. The components of the EBS are the drip shield, waste package, waste form, cladding, emplacement pallet, emplacement drift excavated opening (also referred to as drift opening in this report), and invert. FEPs specific to the waste package, cladding, and drip shield are addressed in separate FEP reports: for example, ''Screening of Features, Events, and Processes in Drip Shield and Waste Package Degradation'' (BSC 2005 [DIRS 174995]), ''Clad Degradation--FEPs Screening Arguments (BSC 2004 [DIRS 170019]), and Waste-Form Features, Events, and Processes'' (BSC 2004 [DIRS 170020]). For included FEPs, this report summarizes the implementation of the FEP in the TSPA-LA (i.e., how the FEP is included). For excluded FEPs, this analysis provides the technical basis for exclusion from TSPA-LA (i.e., why the FEP is excluded). This report also documents changes to the EBS FEPs list that have occurred since the previous versions of this report. These changes have resulted due to a reevaluation of the FEPs for TSPA-LA as identified in Section 1.2 of this report and described in more detail in Section 6.1.1. This revision addresses updates in Yucca Mountain Project

  3. John H. Chafee Coastal Barrier Resources System Approximate Polygons

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Coastal Barrier Resources System (CBRS) data set, produced by the U.S. Fish and Wildlife Service (Service), contains areas designated as undeveloped coastal...

  4. Gas permeability of bentonite barriers: development, construction and testing of a measurement system

    Directory of Open Access Journals (Sweden)

    Heraldo Nunes Pitanga

    Full Text Available Abstract This article proposes a testing device to quickly and reliably estimate the gas permeability of bentonite-based clay barriers used in landfill cover systems. The testing methodology is based on a transient gas flow regime that passes through the barrier, therefore not requiring the use of sophisticated equipment that aim to maintain constant differential pressure and measure the gas flow, common requirements for testing methods under a permanent flow regime. To confirm the feasibility of the proposed technique, tests were performed on a pure hydrated bentonite layer, which subsequently encompassed samples of geosynthetic clay liner (GCL at different moisture contents. Geosynthetic clay liners are often selected as a part of the barrier layer for cover systems in solid waste landfills to prevent infiltration of rainfall and migration of biogas into the atmosphere. The results confirmed the equipment reliability and differentiate the different responses of the gas flow barriers studied, considering their different compositions and different moistures.

  5. Combustion chemical vapor deposited coatings for thermal barrier coating systems

    Energy Technology Data Exchange (ETDEWEB)

    Hampikian, J.M.; Carter, W.B. [Georgia Institute of Technology, Atlanta, GA (United States). School of Materials Science and Engineering

    1995-12-31

    The new deposition process, combustion chemical vapor deposition, shows a great deal of promise in the area of thermal barrier coating systems. This technique produces dense, adherent coatings, and does not require a reaction chamber. Coatings can therefore be applied in the open atmosphere. The process is potentially suitable for producing high quality CVD coatings for use as interlayers between the bond coat and thermal barrier coating, and/or as overlayers, on top of thermal barrier coatings. In this report, the evaluation of alumina and ceria coatings on a nickel-chromium alloy is described.

  6. Barrier function in the peripheral and central nervous system-a review.

    Science.gov (United States)

    Reinhold, A K; Rittner, H L

    2017-01-01

    The peripheral (PNS) and central nervous system (CNS) are delicate structures, highly sensitive to homeostatic changes-and crucial for basic vital functions. Thus, a selection of barriers ensures the protection of the nervous system from noxious blood-borne or surrounding stimuli. In this chapter, anatomy and functioning of the blood-nerve (BNB), the blood-brain (BBB), and the blood-spinal cord barriers (BSCB) are presented and the key tight junction (TJ) proteins described: claudin-1, claudin-3, claudin-5, claudin-11, claudin-12, claudin-19, occludin, Zona occludens-1 (ZO-1), and tricellulin are by now identified as relevant for nerval barriers. Different diseases can lead to or be accompanied by neural barrier disruption, and impairment of these barriers worsens pathology. Peripheral nerve injury and inflammatory polyneuropathy cause an increased permeability of BNB as well as BSCB, while, e.g., diseases of the CNS such as amyotrophic lateral sclerosis, multiple sclerosis, spinal cord injury, or Alzheimer's disease can progress and worsen through barrier dysfunction. Moreover, the complex role and regulation of the BBB after ischemic stroke is described. On the other side, PNS and CNS barriers hamper the delivery of drugs in diseases when the barrier is intact, e.g., in certain neurodegenerative diseases or inflammatory pain. Understanding of the barrier - regulating processes has already lead to the discovery of new molecules as drug enhancers. In summary, the knowledge of all of these mechanisms might ultimately lead to the invention of drugs to control barrier function to help ameliorating or curing neurological diseases.

  7. The role of plants on isolation barrier systems

    Energy Technology Data Exchange (ETDEWEB)

    Link, S.O.; Downs, J.L. [Pacific Northwest Lab., Richland, WA (United States); Waugh, W.J. [UNC Chem-Nuclear Geotech, Grand Junction, CO (United States)

    1994-11-01

    Surface barriers are used to isolate buried wastes from the environment. Most have been built for short-term isolation. The need to isolate radioactive wastes from the environment requires that the functional integrity of a barrier be maintained for thousands of years. Barrier function strongly depends on vegetation. Plants reduce wind and water erosion and minimize drainage, but may transport contaminants if roots extend into buried wastes. Our review of the function of plants on surface barriers focuses on the role of plants across mesic to arid environments and gives special consideration to studies done at Hanford. The Hanford Barrier Development Program was created to design and test an earthen cover system to inhibit water infiltration, plant and animal intrusion, and wind and water erosion, while isolating buried wastes for at least 1000 years. Studies at the Hanford have shown that plants will significantly interact with the barrier. Plants transpire soil water back into the atmosphere. Deep-rooted perennials best recycle water; soil water may drain through the root zone of shallow-rooted annuals. Lysimeter studies indicate that a surface layer of fine soil with deep-rooted plants precludes drainage even with three times normal precipitation. The presence of vegetation greatly reduces water and wind erosion, but deep-rooted plants pose a threat of biointrusion and contaminant transport. The Hanford barrier includes a buried rock layer and asphalt layer to prevent biointrusion.

  8. Particle selectivity of sediment deposited over grass barriers and the effect of rainfall

    Science.gov (United States)

    Pan, Chengzhong; Ma, Lan; Wainwright, John

    2016-10-01

    Particle selectivity of the sediment deposited over vegetative barriers is of importance to predict sediment transport and particulate pollutant load into surface waters. Grassed barriers with 20-90% covers at 15° slope were subjected to silt-laden inflows in the presence and absence of simulated rainfalls to investigate the sediment deposition processes. The results show that regrass of steep croplands can effectively trap eroded sediment from upslope, and the rowed grass barriers can strengthen sediment deposition. The deposition order of sediment particle sizes (μm) follows (>50) > (25-50) > (10-25) = ( (2-10), and the particle selectivity weakens with increasing grass covers. Clay particles had a similar deposition efficiency to overall sediment, implying the effectiveness of regrass in controlling soil nutrient loss. The contribution of grass to total overland flow resistance is almost equivalent to the percentage of grass cover. For steep grassed slopes, raindrop impact significantly decreases sediment deposition, but limitedly affects particle selectivity of deposited sediment and overland flow hydraulics. Both raindrop kinetic energy and stream power available for surface soil contribute to sediment deposition in net deposition areas of grass barriers. These imply that rainfall effect on sediment delivery over vegetated barriers derives from the additional raindrop energy, rather than the variation in runoff hydraulics. These results can help to clarify the effect of raindrop impact on sediment transport and to evaluate the benefit of revegetation in decreasing sediment yield and its particulate nutrient load into surface waters.

  9. Subsurface barrier validation with the SEAtrace{trademark} system

    Energy Technology Data Exchange (ETDEWEB)

    Sandra Dalvit Dunn; William Lowry; Veraun Chipman

    1999-09-01

    Under contract to the Department of Energy, Science and Engineering Associates has completed development and testing of a subsurface barrier verification and monitoring system. This system, called SEAtrace{trademark}, is able to locate and size leaks with a high degree of accuracy in subsurface barriers that are emplaced in an unsaturated medium. It uses gaseous tracer injection, in-field real-time monitoring, and real time data analysis to evaluate barrier integrity. The approach is: Conservative as it measures vapor leaks in a containment system whose greatest risk is posed by liquid leaks; Applicable to any impermeable type of barrier emplacement technology in the unsaturated zone; Inexpensive as it uses readily available, non-toxic, nonhazardous gaseous tracers, does not require an inordinately large number of sampling points, and injection and sampling points can be emplaced by direct push techniques; Capable of assessing not only a barrier's initial integrity, but can also provide long-term monitoring. To date, six demonstrations of the system have been completed. Results from two of the demonstrations are detailed in this report. They include the final developmental demonstration of the SEAtrace system and a comparison demonstration of two tracer based verification technologies. The final developmental demonstration of SEAtrace was completed at a naval facility in Brunswick, Maine. The demonstration was funded solely by the DOE and was performed in cooperation with the US Navy, the Environmental Protection Agency, and the Maine Department of Environmental Protection.

  10. Selection Method for COTS Systems

    DEFF Research Database (Denmark)

    Hedman, Jonas; Andersson, Bo

    2014-01-01

    Historically, organizations developed their information systems in-house. Today, a large portion of information systems development is based on the acquisition of pre-made information systems, so-called commercially off-the-shelf (COTS) systems. This approach for developing information systems...... requires new skills and methods supporting the process of evaluating and selecting information systems. This paper presents a method for selecting COTS systems. The method includes the following phases: problem framing, requirements and appraisal, and selection of systems. The idea and distinguishing...... of approaching the selection of COTS systems as viewing them as a ‘means’ to reach organizational ‘ends’ is different from the mainstream views of information systems development, namely the view that sees information systems development as a problem-solving process, and the underlying ontological view in other...

  11. Annotated bibliography of selected references on shoreline barrier island deposits with emphasis on Patrick Draw Field, Sweetwater County, Wyoming

    Energy Technology Data Exchange (ETDEWEB)

    Rawn-Schatzinger, V.; Schatzinger, R.A.

    1993-07-01

    This bibliography contains 290 annotated references on barrier island and associated depositional environments and reservoirs. It is not an exhaustive compilation of all references on the subject, but rather selected papers on barrier islands, and the depositional processes of formation. Papers that examine the morphology and internal architecture of barrier island deposits, exploration and development technologies are emphasized. Papers were selected that aid in understanding reservoir architecture and engineering technologies to help maximize recovery efficiency from barrier island oil reservoirs. Barrier islands from Wyoming, Montana and the Rocky Mountains basins are extensively covered.

  12. Solvent-dependent on/off valving using selectively permeable barriers in paper microfluidics

    NARCIS (Netherlands)

    Salentijn, G.I.J.; Hamidon, N.N.; Verpoorte, E.

    2016-01-01

    We report on a new way to control solvent flows in paper microfluidic devices, based on the local patterning of paper with alkyl ketene dimer (AKD) to form barriers with selective permeability for different solvents. Production of the devices is a two-step process. In the first step, AKD-treated pap

  13. Microstructural Evolution and interfacial motion in systems with diffusion barriers

    Energy Technology Data Exchange (ETDEWEB)

    Perry H. Leo

    2009-03-05

    This research program was designed to model and simulate phase transformations in systems containing diffusion barriers. The modeling work included mass flow, phase formation, and microstructural evolution in interdiffusing systems. Simulation work was done by developing Cahn-Hilliard and phase field equations governing both the temporal and spatial evolution of the composition and deformation fields and other important phase variables.

  14. Quorum Sensing Peptides Selectively Penetrate the Blood-Brain Barrier.

    Science.gov (United States)

    Wynendaele, Evelien; Verbeke, Frederick; Stalmans, Sofie; Gevaert, Bert; Janssens, Yorick; Van De Wiele, Christophe; Peremans, Kathelijne; Burvenich, Christian; De Spiegeleer, Bart

    2015-01-01

    Bacteria communicate with each other by the use of signaling molecules, a process called 'quorum sensing'. One group of quorum sensing molecules includes the oligopeptides, which are mainly produced by Gram-positive bacteria. Recently, these quorum sensing peptides were found to biologically influence mammalian cells, promoting i.a. metastasis of cancer cells. Moreover, it was found that bacteria can influence different central nervous system related disorders as well, e.g. anxiety, depression and autism. Research currently focuses on the role of bacterial metabolites in this bacteria-brain interaction, with the role of the quorum sensing peptides not yet known. Here, three chemically diverse quorum sensing peptides were investigated for their brain influx (multiple time regression technique) and efflux properties in an in vivo mouse model (ICR-CD-1) to determine blood-brain transfer properties: PhrCACET1 demonstrated comparatively a very high initial influx into the mouse brain (Kin = 20.87 μl/(g×min)), while brain penetrabilities of BIP-2 and PhrANTH2 were found to be low (Kin = 2.68 μl/(g×min)) and very low (Kin = 0.18 μl/(g×min)), respectively. All three quorum sensing peptides were metabolically stable in plasma (in vitro) during the experimental time frame and no significant brain efflux was observed. Initial tissue distribution data showed remarkably high liver accumulation of BIP-2 as well. Our results thus support the potential role of some quorum sensing peptides in different neurological disorders, thereby enlarging our knowledge about the microbiome-brain axis.

  15. Engineered Barrier Systems Thermal-Hydraulic-Chemical Column Test Report

    Energy Technology Data Exchange (ETDEWEB)

    W.E. Lowry

    2001-12-13

    The Engineered Barrier System (EBS) Thermal-Hydraulic-Chemical (THC) Column Tests provide data needed for model validation. The EBS Degradation, Flow, and Transport Process Modeling Report (PMR) will be based on supporting models for in-drift THC coupled processes, and the in-drift physical and chemical environment. These models describe the complex chemical interaction of EBS materials, including granular materials, with the thermal and hydrologic conditions that will be present in the repository emplacement drifts. Of particular interest are the coupled processes that result in mineral and salt dissolution/precipitation in the EBS environment. Test data are needed for thermal, hydrologic, and geochemical model validation and to support selection of introduced materials (CRWMS M&O 1999c). These column tests evaluated granular crushed tuff as potential invert ballast or backfill material, under accelerated thermal and hydrologic environments. The objectives of the THC column testing are to: (1) Characterize THC coupled processes that could affect performance of EBS components, particularly the magnitude of permeability reduction (increases or decreases), the nature of minerals produced, and chemical fractionation (i.e., concentrative separation of salts and minerals due to boiling-point elevation). (2) Generate data for validating THC predictive models that will support the EBS Degradation, Flow, and Transport PMR, Rev. 01.

  16. Engineered Barrier System performance requirements systems study report. Revision 02

    Energy Technology Data Exchange (ETDEWEB)

    Balady, M.A.

    1997-01-14

    This study evaluates the current design concept for the Engineered Barrier System (EBS), in concert with the current understanding of the geologic setting to assess whether enhancements to the required performance of the EBS are necessary. The performance assessment calculations are performed by coupling the EBS with the geologic setting based on the models (some of which were updated for this study) and assumptions used for the 1995 Total System Performance Assessment (TSPA). The need for enhancements is determined by comparing the performance assessment results against the EBS related performance requirements. Subsystem quantitative performance requirements related to the EBS include the requirement to allow no more than 1% of the waste packages (WPs) to fail before 1,000 years after permanent closure of the repository, as well as a requirement to control the release rate of radionuclides from the EBS. The EBS performance enhancements considered included additional engineered components as well as evaluating additional performance available from existing design features but for which no performance credit is currently being taken.

  17. Low temperature monitoring system for subsurface barriers

    Science.gov (United States)

    Vinegar, Harold J.; McKinzie, II. Billy John

    2009-08-18

    A system for monitoring temperature of a subsurface low temperature zone is described. The system includes a plurality of freeze wells configured to form the low temperature zone, one or more lasers, and a fiber optic cable coupled to at least one laser. A portion of the fiber optic cable is positioned in at least one freeze well. At least one laser is configured to transmit light pulses into a first end of the fiber optic cable. An analyzer is coupled to the fiber optic cable. The analyzer is configured to receive return signals from the light pulses.

  18. YMP Engineered Barrier Systems Scaled Ventilation Testing

    Energy Technology Data Exchange (ETDEWEB)

    S.D. Dunn; B. Lowry; B. Walsh; J.D. Mar; C. Howard; R. Johnston; T. Williams

    2002-11-22

    Yucca Mountain, approximately 100 miles northwest of Las Vegas, Nevada, has been selected as the site for the nation's first geologic repository for high level nuclear waste. The Yucca Mountain Project (YMP) is currently developing the design for the underground facilities. Ventilation is a key component of the design as a way to maintain the desired thermal conditions in the emplacement drifts prior to closure. As a means of determining the effects of continuous ventilation on heat removal from the emplacement drifts two series of scaled ventilation tests have been performed. Both test series were performed in the DOE/North Las Vegas Atlas facility. The tests provided scaled (nominally 25% of the full scale emplacement drift design) thermal and flow process data that will be used to validate YMP heat and mass transport codes. The Phase I Ventilation Test series evaluated the ability of ambient ventilation air to remove energy under varying flow and input power conditions. The Phase II Ventilation Test series evaluated the ability of pre-conditioned ventilation air to remove energy under varying flow, input temperature and moisture content, and simulated waste package input power conditions. Twenty-two distinct ventilation tests were run.

  19. Solvent-dependent on/off valving using selectively permeable barriers in paper microfluidics.

    Science.gov (United States)

    Salentijn, G Ij; Hamidon, N N; Verpoorte, E

    2016-03-21

    We report on a new way to control solvent flows in paper microfluidic devices, based on the local patterning of paper with alkyl ketene dimer (AKD) to form barriers with selective permeability for different solvents. Production of the devices is a two-step process. In the first step, AKD-treated paper (hydrophobic) is exposed to oxygen plasma for re-hydrophilization. 3D-printed masks are employed to shield certain areas of this paper to preserve well-defined hydrophobic patterns. In the second step, concentrated AKD in hexane is selectively deposited onto already hydrophobic regions of the paper to locally increase the degree of hydrophobicity. Hydrophilic areas formed in the previous oxygen plasma step are protected from AKD by wetting them with water first to prevent the AKD hexane solution from entering them (hydrophilic exclusion). Characterization of the patterns after both steps shows that reproducible patterns are obtained with linear dependence on the dimensions of the 3D-printed masks. This two-step methodology leads to differential hydrophobicity on the paper: (i) hydrophilic regions, (ii) low-load AKD gates, and (iii) high-load AKD walls. The gates are impermeable to water, yet can be penetrated by most alcohol/water mixtures; the walls cannot. This concept for solvent-dependent on/off valving is demonstrated in two applications. In the first example, a device was developed for multi-step chemical reactions. Different compounds can be spotted separately (closed gates). Upon elution with an alcohol/water mixture, the gates become permeable and the contents are combined. In the second example, volume-defined sampling is introduced. Aqueous sample is allowed to wick into a device and fill a sample chamber. The contents of this sample chamber are eluted perpendicularly with an alcohol/water mixture through a selectively permeable gate. This system was tested with dye solution, and a linear dependence of magnitude of the signal on the sample chamber size was

  20. Origin of Small Barriers in Jahn–Teller Systems

    DEFF Research Database (Denmark)

    Barriuso, M. T.; Ortiz-Sevilla, B.; Aramburu, J. A.

    2013-01-01

    Despite its relevance, the microscopic origin of the energy barrier, B, between the compressed and elongated geometries of Jahn–Teller (JT) systems is not well understood yet because of a lack of quantitative data about its various contributions. Seeking to clear up this matter, we have carried o...

  1. Experimental Study on Spiral Patterns in Dielectric Barrier Discharge System

    Institute of Scientific and Technical Information of China (English)

    LIU Shu-Hua; DONG Li-Fang; LIU Fu-Cheng; LI Shu-Feng; LI Xue-Chen; WANG Hong-Fang

    2006-01-01

    Spiral patterns are obtained in a dielectric barrier discharge system with water electrodes. The dynamics of spiral formation and transition is investigated. Wavelength characteristic of spiral patterns is also studied. Correlation measurements indicate that the wavelength of spiral pattern increases with the increasing gas gap width and oscillates with the increasing drive frequency.

  2. Case study of a novel geocomposite barrier system for hydrocarbon containment on Brevoort Island

    Energy Technology Data Exchange (ETDEWEB)

    Bathurst, R.J.; Zeeb, B.; Reimer, K. [Royal Military Coll. of Canada, Kingston, ON (Canada); Rowe, R.K. [Queen' s Univ., Kingston, ON (Canada)

    2005-07-01

    North Warning System Office has undertaken a program focused on the cleanup of Canadian District Early Warning Line and Pole Vault sites located on the Canadian sub-Arctic and Arctic coastline. The implementation plan emphasizes cost-effective methods of preventing the movement of chemical contaminants into the ecosystem. This paper describes remediation steps that were taken to restrict the migration of a hydrocarbon plume before the excavation of contaminated ground at a Pole Vault site on Brevoort Island. This is the first published field application of a fluorinated geomembrane. A composite liner consisting of fluorine surface-treated polyethylene geomembrane and a geosynthetic clay liner was chosen as a barrier against hydrocarbon migration until full remediation measures could be applied. Design details, selection criteria and various challenges in the installation procedure were presented. Due to the remoteness of the location and the extremes of temperature, a site monitoring program was also initiated. Details of the programs were also presented, along with details of a parallel program of laboratory testing, initiated to investigate the long-term effects of contact with jet fuel on specimens of the barrier components as well as freeze-thaw and general lower temperatures. Results indicated that the barrier system was performing as planned. Laboratory tests indicated that the geosynthetic materials selected for the Brevoort site were expected to maintain low rates of hydrocarbon diffusion and advection beyond the original design life of the barrier system. 14 refs., 10 figs.

  3. ENGINEERED BARRIER SYSTEM FEATURES, EVENTS, AND PROCESSES

    Energy Technology Data Exchange (ETDEWEB)

    na

    2005-05-30

    This analysis report is one of the technical reports containing documentation of the Environmental Radiation Model for Yucca Mountain, Nevada (ERMYN), a biosphere model supporting the total system performance assessment (TSPA) for the license application (LA) for the Yucca Mountain repository. This analysis report describes the development of biosphere dose conversion factors (BDCFs) for the volcanic ash exposure scenario, and the development of dose factors for calculating inhalation dose during volcanic eruption. A graphical representation of the documentation hierarchy for the ERMYN is presented in Figure 1 - 1. This figure shows the interrelationships among the products (i.e., analysis and model reports) developed for biosphere modeling and provides an understanding of how this analysis report contributes to biosphere modeling. This report is one of two reports that develop biosphere BDCFs, which are input parameters for the TSPA model. The ''Biosphere Model Report'' (BSC 2004 [DIRS 169460]) describes in detail the ERMYN conceptual model and mathematical model. The input parameter reports, shown to the right of the Biosphere Model Report in Figure 1-1, contain detailed descriptions of the model input parameters, their development and the relationship between the parameters and specific features, events and processes (FEPs). This report describes biosphere model calculations and their output, the BDCFs, for the volcanic ash exposure scenario. This analysis receives direct input from the outputs of the ''Biosphere Model Report'' (BSC 2004 [DIRS 169460]) and from the five analyses that develop parameter values for the biosphere model (BSC 2005 [DIRS 172827]; BSC 2004 [DIRS 169672]; BSC 2004 [DIRS 169673]; BSC 2004 [DIRS 169458]; and BSC 2004 [DIRS 169459]). The results of this report are further analyzed in the ''Biosphere Dose Conversion Factor Importance and Sensitivity Analysis'' (Figure 1 - 1). The

  4. Engineered Barrier System: Physical and Chemical Environment Model

    Energy Technology Data Exchange (ETDEWEB)

    D. M. Jolley; R. Jarek; P. Mariner

    2004-02-09

    The conceptual and predictive models documented in this Engineered Barrier System: Physical and Chemical Environment Model report describe the evolution of the physical and chemical conditions within the waste emplacement drifts of the repository. The modeling approaches and model output data will be used in the total system performance assessment (TSPA-LA) to assess the performance of the engineered barrier system and the waste form. These models evaluate the range of potential water compositions within the emplacement drifts, resulting from the interaction of introduced materials and minerals in dust with water seeping into the drifts and with aqueous solutions forming by deliquescence of dust (as influenced by atmospheric conditions), and from thermal-hydrological-chemical (THC) processes in the drift. These models also consider the uncertainty and variability in water chemistry inside the drift and the compositions of introduced materials within the drift. This report develops and documents a set of process- and abstraction-level models that constitute the engineered barrier system: physical and chemical environment model. Where possible, these models use information directly from other process model reports as input, which promotes integration among process models used for total system performance assessment. Specific tasks and activities of modeling the physical and chemical environment are included in the technical work plan ''Technical Work Plan for: In-Drift Geochemistry Modeling'' (BSC 2004 [DIRS 166519]). As described in the technical work plan, the development of this report is coordinated with the development of other engineered barrier system analysis model reports.

  5. Diffusion Barrier Coating System and Oxidation Behavior of Coated Alloys

    Institute of Scientific and Technical Information of China (English)

    T.NARITA

    2009-01-01

    @@ 1 Introduction Research into the formation of Re-based alloys is in progress in our laboratory to provide a diffusion barrier layer between heat-resistant alloys and Al reservoir layers, which assist in the formation and maintenance a protective Al2O3 scale for long periods. Coatings with a two-layered structure comprised of inner Re-based alloy layer and outer β-NiAl layer with or without Pt addition were successfully formed on various heat resistant alloys such as Ni-based singlecrystal superalloys, Ni-based heat resistant alloys, NiMo based alloy, Ni-Cr based alloy, and Fe-based alloys. The duplex layer coating proposed is generally termed a diffusion barrier coating system; DBC system.

  6. A preliminary experimental study on virtual sound barrier system

    Science.gov (United States)

    Zou, Haishan; Qiu, Xiaojun; Lu, Jing; Niu, Feng

    2007-10-01

    Virtual sound barrier (VSB) is an array of loudspeakers and microphones forming an acoustic barrier, which creates a quiet zone without blocking air and light. A 16-channel cylindrical VSB system has been developed and its feasibility is verified by both numerical simulations and experiments. Experimental results in a normal room show that it can create a quiet zone larger than the size of a human head in the low-middle frequency, with a total sound pressure level reduction of more than 10 dB in the quiet zone. The control performance of the system with respect to the frequency, the distribution of the error sensors and the control sources are discussed.

  7. Thermal and Environmental Barrier Coatings for Advanced Propulsion Engine Systems

    Science.gov (United States)

    Zhu, Dong-Ming; Miller, Robert A.

    2004-01-01

    Ceramic thermal and environmental barrier coatings (TEBCs) are used in gas turbine engines to protect engine hot-section components in the harsh combustion environments, and extend component lifetimes. For future high performance engines, the development of advanced ceramic barrier coating systems will allow these coatings to be used to simultaneously increase engine operating temperature and reduce cooling requirements, thereby leading to significant improvements in engine power density and efficiency. In order to meet future engine performance and reliability requirements, the coating systems must be designed with increased high temperature stability, lower thermal conductivity, and improved thermal stress and erosion resistance. In this paper, ceramic coating design and testing considerations will be described for high temperature and high-heat-flux engine applications in hot corrosion and oxidation, erosion, and combustion water vapor environments. Further coating performance and life improvements will be expected by utilizing advanced coating architecture design, composition optimization, and improved processing techniques, in conjunction with modeling and design tools.

  8. Computational Design and Experimental Validation of New Thermal Barrier Systems

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shengmin; Yang, Shizhong; Khosravi, Ebrahim

    2014-04-01

    This project (10/01/2010-9/30/2014), “Computational Design and Experimental Validation of New Thermal Barrier Systems”, originates from Louisiana State University (LSU) Mechanical Engineering Department and Southern University (SU) Department of Computer Science. This project will directly support the technical goals specified in DE-FOA-0000248, Topic Area 3: Turbine Materials, by addressing key technologies needed to enable the development of advanced turbines and turbine-based systems that will operate safely and efficiently using coal-derived synthesis gases. In this project, the focus is to develop and implement novel molecular dynamics method to improve the efficiency of simulation on novel TBC materials; perform high performance computing (HPC) on complex TBC structures to screen the most promising TBC compositions; perform material characterizations and oxidation/corrosion tests; and demonstrate our new thermal barrier coating (TBC) systems experimentally under integrated gasification combined cycle (IGCC) environments.

  9. TRITIUM BARRIER MATERIALS AND SEPARATION SYSTEMS FOR THE NGNP

    Energy Technology Data Exchange (ETDEWEB)

    Sherman, S; Thad Adams, T

    2008-07-17

    Contamination of downstream hydrogen production plants or other users of high-temperature heat is a concern of the Next Generation Nuclear Plant (NGNP) Project. Due to the high operating temperatures of the NGNP (850-900 C outlet temperature), tritium produced in the nuclear reactor can permeate through heat exchangers to reach the hydrogen production plant, where it can become incorporated into process chemicals or the hydrogen product. The concentration limit for tritium in the hydrogen product has not been established, but it is expected that any future limit on tritium concentration will be no higher than the air and water effluent limits established by the NRC and the EPA. A literature survey of tritium permeation barriers, capture systems, and mitigation measures is presented and technologies are identified that may reduce the movement of tritium to the downstream plant. Among tritium permeation barriers, oxide layers produced in-situ may provide the most suitable barriers, though it may be possible to use aluminized surfaces also. For tritium capture systems, the use of getters is recommended, and high-temperature hydride forming materials such as Ti, Zr, and Y are suggested. Tritium may also be converted to HTO in order to capture it on molecular sieves or getter materials. Counter-flow of hydrogen may reduce the flux of tritium through heat exchangers. Recommendations for research and development work are provided.

  10. Implementation of electronic data capture systems: barriers and solutions.

    Science.gov (United States)

    Welker, James A

    2007-05-01

    Although increasing in pace, the conversion to Electronic Data Capture (EDC) has been a slow progression. The use of EDC systems should confer improved data integrity, cost savings and a shorter time to study database closure. This will reduce the time to market and cost of new medications. With the current sentiment of the industry suggesting the cost analysis has been accepted to be in favor of EDC, the likely limitation to disseminated use is an inability to implement these systems. If the leadership at the sponsor, clinical research organization and investigator site is cognizant of the barriers to implementation, they can anticipate and mitigate them prior to the users becoming disgruntled and resistant to the new method of data capture. Once understood, barriers such as user input, technical support, user motivation, regulatory requirements, communication with users, timing of implementation, software installation, graphical user interface, identification of bridgers, patient participation, availability of technology, and costs can be better addressed at the beginning of the implementation process and successfully averted. This review discusses these barriers and potential solutions that can assist the clinical trial industry in achieving more wide-spread EDC use and the resulting improvement in operating efficiencies.

  11. Computational design and experimental validation of new thermal barrier systems

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shengmin [Louisiana State Univ., Baton Rouge, LA (United States)

    2015-03-31

    The focus of this project is on the development of a reliable and efficient ab initio based computational high temperature material design method which can be used to assist the Thermal Barrier Coating (TBC) bond-coat and top-coat design. Experimental evaluations on the new TBCs are conducted to confirm the new TBCs’ properties. Southern University is the subcontractor on this project with a focus on the computational simulation method development. We have performed ab initio density functional theory (DFT) method and molecular dynamics simulation on screening the top coats and bond coats for gas turbine thermal barrier coating design and validation applications. For experimental validations, our focus is on the hot corrosion performance of different TBC systems. For example, for one of the top coatings studied, we examined the thermal stability of TaZr2.75O8 and confirmed it’s hot corrosion performance.

  12. Selective Permeabilization of the Blood–Brain Barrier at Sites of Metastasis

    OpenAIRE

    Sibson, NR; Vallis, KA; Hamilton, A.; Seymour, L.; Anthony, DC; Connell, JJ; Chatain, G

    2013-01-01

    BACKGROUND: Effective chemotherapeutics for primary systemic tumors have limited access to brain metastases because of the blood-brain barrier (BBB). The aim of this study was to develop a strategy for specifically permeabilizing the BBB at sites of cerebral metastases. METHODS: BALB/c mice were injected intracardially to induce brain metastases. After metastasis induction, either tumor necrosis factor (TNF) or lymphotoxin (LT) was administered intravenously, and 2 to 24 hours later gadoliniu...

  13. Selective induction of P-glycoprotein at the CNS barriers during symptomatic stage of an ALS animal model.

    Science.gov (United States)

    Chan, Gary N Y; Evans, Rebecca A; Banks, David B; Mesev, Emily V; Miller, David S; Cannon, Ronald E

    2017-02-03

    P-glycoprotein (P-gp), Breast cancer resistance protein (BCRP) and Multidrug resistance-associated protein 2 (MRP2) residing at the blood-brain barrier (BBB) and the blood-spinal cord barrier (BSCB) are major obstacles for drug delivery to the Central Nervous System (CNS). Disease-induced changes of these xenobiotic transporters at the CNS barriers have been previously documented. Changes in the functional expression of these transporters at the CNS barriers would limit the clinical efficacy of therapeutic agents targeting the CNS. In this study, we characterized the changes in expression and efflux activity of P-gp, BCRP and MRP2 at the BBB and BSCB of an amyotrophic lateral sclerosis (ALS) SOD1-G93A transgenic rat model across the three stages of disease progression: pre-onset, onset and symptomatic. Up-regulation of P-gp and BCRP at the BBB and BSCB during disease progression of ALS would reduce drug entry to the CNS, while any decreases in transport activity would increase drug entry. In SOD rats at the ALS symptomatic stage, we observed increases in both P-gp transport activity and expression compared to age-matched wildtypes. BCRP and MRP2 levels were unchanged in these animals. Immunohistochemical analysis in brain and spinal cord capillaries of SOD rats from all three ALS stages and age-matched wildtypes showed no differences in nuclear localization of a known P-gp regulator, nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB). It suggests that NFκB may have a limited role during P-gp induction observed in our study and additional signaling pathways could be responsible for this response. Our observations imply that novel pharmacological approaches for treating ALS require selecting drugs that are not P-gp substrates in order to improve therapeutic efficacy in the CNS during ALS progression.

  14. Production Systems and Supplier Selection

    DEFF Research Database (Denmark)

    Pedraza-Acosta, Isabel; Pilkington, Alan; Barnes, David

    2016-01-01

    strategic stamping suppliers. Findings: Our contribution is the multi-phased production and product innovation process. This is an advance from traditional supplier selection and also an extension of ideas of supplier-located product development as it includes production system development, and complements......Purpose: This paper presents a combined multi-phase supplier selection model. The process repeatedly revisits the criteria and sourcing decision as the development process continues. This enables a structured adoption of product and production system innovation from strategic suppliers, where...... the literature on working with strategic suppliers. Specifically, we explicitly articulate the previously unreported issue of whether a supplier chosen for its innovation capabilities at the start of the new product development process will also be the most appropriate supplier during the production system...

  15. Towards a barrier height benchmark set for biologically relevant systems

    Directory of Open Access Journals (Sweden)

    Jimmy C. Kromann

    2016-05-01

    Full Text Available We have collected computed barrier heights and reaction energies (and associated model structures for five enzymes from studies published by Himo and co-workers. Using this data, obtained at the B3LYP/6- 311+G(2d,2p[LANL2DZ]//B3LYP/6-31G(d,p level of theory, we then benchmark PM6, PM7, PM7-TS, and DFTB3 and discuss the influence of system size, bulk solvation, and geometry re-optimization on the error. The mean absolute differences (MADs observed for these five enzyme model systems are similar to those observed for PM6 and PM7 for smaller systems (10–15 kcal/mol, while DFTB results in a MAD that is significantly lower (6 kcal/mol. The MADs for PMx and DFTB3 are each dominated by large errors for a single system and if the system is disregarded the MADs fall to 4–5 kcal/mol. Overall, results for the condensed phase are neither more or less accurate relative to B3LYP than those in the gas phase. With the exception of PM7-TS, the MAD for small and large structural models are very similar, with a maximum deviation of 3 kcal/mol for PM6. Geometry optimization with PM6 shows that for one system this method predicts a different mechanism compared to B3LYP/6-31G(d,p. For the remaining systems, geometry optimization of the large structural model increases the MAD relative to single points, by 2.5 and 1.8 kcal/mol for barriers and reaction energies. For the small structural model, the corresponding MADs decrease by 0.4 and 1.2 kcal/mol, respectively. However, despite these small changes, significant changes in the structures are observed for some systems, such as proton transfer and hydrogen bonding rearrangements. The paper represents the first step in the process of creating a benchmark set of barriers computed for systems that are relatively large and representative of enzymatic reactions, a considerable challenge for any one research group but possible through a concerted effort by the community. We end by outlining steps needed to expand and

  16. Effect of guanidine hydrochloride on removal rate selectivity and wafer topography modification in barrier CMP

    Science.gov (United States)

    Hailong, Li; Jin, Kang; Yuling, Liu; Chenwei, Wang; Hong, Liu; Jiaojiao, Gao

    2014-03-01

    We propose an alkaline barrier slurry containing guanidine hydrochloride (GH) and hydrogen peroxide. The slurry does not contain any corrosion inhibitors, such as benzotriazole (BTA). 3-inch samples of tantalum copper and oxide were polished to observe the removal rate. The effect of GH on removal rate selectivity along with hydrogen peroxide was investigated by comparing slurry containing GH and H2O2 with slurry containing only GH. Details about the tantalum polishing mechanism in an alkaline guanidine-based slurry and the electrochemical reactions are discussed. The results show that guanidine hydrochloride can increase the tantalum polishing rate and the selectivity of copper and barrier materials. The variation of the dishing and wire line resistance with the polishing time was measured. The dishing value after a 300 mm pattern wafer polishing suggests that the slurry has an effective performance in topography modification. The result obtained from the copper wire line resistance test reveals that the wire line in the trench has a low copper loss.

  17. Computational Design and Experimental Validation of New Thermal Barrier Systems

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shengmin; Yang, Shizhong; Khosravi, Ebrahim

    2011-12-31

    This project (10/01/2010-9/30/2013), “Computational Design and Experimental Validation of New Thermal Barrier Systems”, originates from Louisiana State University (LSU) Mechanical Engineering Department and Southern University (SU) Department of Computer Science. This proposal will directly support the technical goals specified in DE-FOA-0000248, Topic Area 3: Turbine Materials, by addressing key technologies needed to enable the development of advanced turbines and turbine-based systems that will operate safely and efficiently using coal-derived synthesis gases. We will develop novel molecular dynamics method to improve the efficiency of simulation on novel TBC materials; we will perform high performance computing (HPC) on complex TBC structures to screen the most promising TBC compositions; we will perform material characterizations and oxidation/corrosion tests; and we will demonstrate our new Thermal barrier coating (TBC) systems experimentally under Integrated gasification combined cycle (IGCC) environments. The durability of the coating will be examined using the proposed High Temperature/High Pressure Durability Test Rig under real syngas product compositions.

  18. Implementation of multiple-domain covering computerized decision support systems in primary care: a focus group study on perceived barriers

    NARCIS (Netherlands)

    Lugtenberg, M.; Weenink, J.W.; Weijden, T. van der; Westert, G.P.; Kool, R.B.

    2015-01-01

    BACKGROUND: Despite the widespread availability of computerized decision support systems (CDSSs) in various healthcare settings, evidence on their uptake and effectiveness is still limited. Most barrier studies focus on CDSSs that are aimed at a limited number of decision points within selected smal

  19. Implementation of multiple-domain covering computerized decision support systems in primary care : A focus group study on perceived barriers

    NARCIS (Netherlands)

    Lugtenberg, M.; Weenink, Jan-Willem; van der Weijden, Trudy; Westert, G.P.; Kool, Rudolf B.

    2015-01-01

    Background Despite the widespread availability of computerized decision support systems (CDSSs) in various healthcare settings, evidence on their uptake and effectiveness is still limited. Most barrier studies focus on CDSSs that are aimed at a limited number of decision points within selected small

  20. Identifying the management barriers for establishing suggestions system: A case study of educational system

    Directory of Open Access Journals (Sweden)

    Masoud Nouri

    2012-10-01

    Full Text Available Suggestions system is one of the new cooperative management plans, which affects making good decisions, self-confidence and employees occupational approval. The aim of this research is to survey the barriers for establishment of suggestion system. The proposed study designs and distributes a questionnaire among 195 out of 26550 managers who work for educational system in city of Kermanshah, Iran. The primary purpose of this survey is to learn whether lack of accepting any risk on behalf of management team, conflict of interest in management style, lack of belief on suggestions system in an organization are important barriers of executing suggestions system in an organization or not. The results of Freedman test confirm all seven components of the hypothesis. As a result, lack of accepting risk among management team is number one barrier in having suggestion system followed by existing conflict between management style and suggestions system and lack of management's belief to suggestions system, weakness in education for suggestions system and fear in management disruption because of having suggestions system. The other barriers coming in the last priority in terms of their relative importance include lack of management's support to suggestions system and weakness in management position because of accepting suggestions system.

  1. Representing solute transport through the multi-barrier disposal system by simplified concepts

    Energy Technology Data Exchange (ETDEWEB)

    Poteri, A.; Nordman, H.; Pulkkanen, V-M. [VTT Technical Research Centre of Finland, Espoo (Finland); Kekaelaeinen, P. [Jyvaeskylae Univ. (Finland). Dept. pf Physics; Hautojaervi, A.

    2012-02-15

    The repository system chosen in Finland for spent nuclear fuel is composed of multiple successive transport barriers. If a waste canister is leaking, this multi-barrier system retards and limits the release rates of radionuclides into the biosphere. Analysis of radionuclide migration in the previous performance assessments has largely been based on numerical modelling of the repository system. The simplified analytical approach introduced here provides a tool to analyse the performance of the whole system using simplified representations of the individual transport barriers. This approach is based on the main characteristics of the individual barriers and on the generic nature of the coupling between successive barriers. In the case of underground repository the mass transfer between successive transport barriers is strongly restricted by the interfaces between barriers leading to well-mixed conditions in these barriers. The approach here simplifies the barrier system so that it can be described with a very simple compartment model, where each barrier is represented by a single, or in the case of buffer, by not more than two compartments. This system of compartments could be solved in analogy with a radioactive decay chain. The model of well mixed compartments lends itself to a very descriptive way to represent and analyse the barrier system because the relative efficiency of the different barriers in hindering transport of solutes can be parameterised by the solutes half-times in the corresponding compartments. In a real repository system there will also be a delay between the start of the inflow and the start of the outflow from the barrier. This delay can be important for the release rates of the short lived and sorbing radionuclides, and it was also included in the simplified representation of the barrier system. In a geological multi-barrier system, spreading of the outflowing release pulse is often governed by the typical behaviour of one transport barrier

  2. Curvature behaviour of multilayer specimens of thermal barrier systems

    Energy Technology Data Exchange (ETDEWEB)

    Blandin, G.; Bruenings, S.E.; Steinbrech, R.W.; Singheiser, L. [Forschungszentrum Juelich GmbH (Germany). Inst. fuer Werkstoffe und Verfahren der Energietechnik

    2000-07-01

    The impact of residual stresses on the elastic and plastic deformation behavior of plasma sprayed and physical vapor deposited thermal barrier systems was studied. In particular, multilayer specimen strips composed of plasma sprayed partially stabilized zirconia, oxidation resistant NiCoCrAlY bond-coat and Ni-based superalloy substrate were tested. The experiments focused on the in-situ observation of specimen curvature during thermal cycling between room temperature and 1000 C. The mechanical response of specimens with different layer thickness was analyzed with a thermoelastic model to derive elastic modulus and thermal expansion of the ceramic top coat, both parameters as a function of temperature. With the thermoelastic data of all three layers, the residual stress distribution could be calculated analytically. The results of the two coating variants are compared. The deviation from thermoelastic behavior at higher temperature is discussed in terms of stress relaxation in the bond coat due to plastic deformation. (orig.)

  3. PEBS. Long-term performance of engineered barrier systems

    Energy Technology Data Exchange (ETDEWEB)

    Wieczorek, Klaus; Czaikowski, Oliver; Miehe, Ruediger

    2014-12-15

    The evolution of the engineered barrier system (EBS) of geological repositories for radioactive waste has been the subject of many national and international research programmes. The emphasis of the research activities was on the elaboration of a detailed understanding of the complex THMC processes, which are expected to evolve in the early post closure period in the near field. From the perspective of radiological long-term safety, an in-depth understanding of these coupled processes is of great significance, because the evolution of the EBS during the early post-closure phase may have a non-negligible impact on the radiological safety functions at the time when the canisters breach. Unexpected process interactions during the resaturation phase could impair the safety-relevant parameters in the EBS (e. g. swelling pressure, hydraulic conductivity, diffusivity).

  4. Nanoscale drug delivery systems and the blood–brain barrier

    Directory of Open Access Journals (Sweden)

    Alyautdin R

    2014-02-01

    Full Text Available Renad Alyautdin,1 Igor Khalin,2 Mohd Ismail Nafeeza,1 Muhammad Huzaimi Haron,1 Dmitry Kuznetsov31Faculty of Medicine, Universiti Teknologi MARA (UiTM, Sungai Buloh, Selangor, Malaysia; 2Faculty of Medicine and Defence Health, National Defence University of Malaysia (NDUM, Kuala Lumpur, Malaysia; 3Department of Medicinal Nanobiotechnologies, N. I. Pirogoff Russian State Medical University, Moscow, RussiaAbstract: The protective properties of the blood–brain barrier (BBB are conferred by the intricate architecture of its endothelium coupled with multiple specific transport systems expressed on the surface of endothelial cells (ECs in the brain's vasculature. When the stringent control of the BBB is disrupted, such as following EC damage, substances that are safe for peripheral tissues but toxic to neurons have easier access to the central nervous system (CNS. As a consequence, CNS disorders, including degenerative diseases, can occur independently of an individual's age. Although the BBB is crucial in regulating the biochemical environment that is essential for maintaining neuronal integrity, it limits drug delivery to the CNS. This makes it difficult to deliver beneficial drugs across the BBB while preventing the passage of potential neurotoxins. Available options include transport of drugs across the ECs through traversing occludins and claudins in the tight junctions or by attaching drugs to one of the existing transport systems. Either way, access must specifically allow only the passage of a particular drug. In general, the BBB allows small molecules to enter the CNS; however, most drugs with the potential to treat neurological disorders other than infections have large structures. Several mechanisms, such as modifications of the built-in pumping-out system of drugs and utilization of nanocarriers and liposomes, are among the drug-delivery systems that have been tested; however, each has its limitations and constraints. This review

  5. Stochastic Resonance of Single (Independent of Each Other) Protein Motor System with Fluctuating Potential Barrier

    Institute of Scientific and Technical Information of China (English)

    MA Song-Hua; LI Jing-Hui; JIANG Yong-Qing; FANG Jian-Ping

    2008-01-01

    A single (independent of each other) protein motor system with fluctuating potential barrier and subject to sine electric field is investigated. We first derive the approximate Langevin equation of this system with fluctuating potential barrier. Then from this approximate Langevin equation, we calculate the signal-to-noise ratio (SNR) in the adiabatic limit. The phenomenon of stochastic resonance is found for this protein motor system with fluctuating potential barrier.

  6. Prezygotic barriers to hybridization in marine broadcast spawners: reproductive timing and mating system variation.

    Directory of Open Access Journals (Sweden)

    Carla A Monteiro

    Full Text Available Sympatric assemblages of congeners with incomplete reproductive barriers offer the opportunity to study the roles that ecological and non-ecological factors play in reproductive isolation. While interspecific asynchrony in gamete release and gametic incompatibility are known prezygotic barriers to hybridization, the role of mating system variation has been emphasized in plants. Reproductive isolation between the sibling brown algal species Fucus spiralis, Fucus guiryi (selfing hermaphrodite and Fucus vesiculosus (dioecious was studied because they form hybrids in parapatry in the rocky intertidal zone, maintain species integrity over a broad geographic range, and have contrasting mating systems. We compared reproductive synchrony (spawning overlap between the three species at several temporal scales (yearly/seasonal, semilunar/tidal, and hourly during single tides. Interspecific patterns of egg release were coincident at seasonal (single peak in spring to early summer to semilunar timescales. Synthesis of available data indicated that spawning is controlled by semidiurnal tidal and daily light-dark cues, and not directly by semilunar cycles. Importantly, interspecific shifts in timing detected at the hourly scale during single tides were consistent with a partial ecological prezygotic hybridization barrier. The species displayed patterns of gamete release consistent with a power law distribution, indicating a high degree of reproductive synchrony, while the hypothesis of weaker selective constraints for synchrony in selfing versus outcrossing species was supported by observed spawning in hermaphrodites over a broader range of tidal phase than in outcrossers. Synchronous gamete release is critical to the success of external fertilization, while high-energy intertidal environments may offer only limited windows of reproductive opportunity. Within these windows, however, subtle variations in reproductive timing have evolved with the potential to

  7. Nanoscale drug delivery systems and the blood-brain barrier.

    Science.gov (United States)

    Alyautdin, Renad; Khalin, Igor; Nafeeza, Mohd Ismail; Haron, Muhammad Huzaimi; Kuznetsov, Dmitry

    2014-01-01

    The protective properties of the blood-brain barrier (BBB) are conferred by the intricate architecture of its endothelium coupled with multiple specific transport systems expressed on the surface of endothelial cells (ECs) in the brain's vasculature. When the stringent control of the BBB is disrupted, such as following EC damage, substances that are safe for peripheral tissues but toxic to neurons have easier access to the central nervous system (CNS). As a consequence, CNS disorders, including degenerative diseases, can occur independently of an individual's age. Although the BBB is crucial in regulating the biochemical environment that is essential for maintaining neuronal integrity, it limits drug delivery to the CNS. This makes it difficult to deliver beneficial drugs across the BBB while preventing the passage of potential neurotoxins. Available options include transport of drugs across the ECs through traversing occludins and claudins in the tight junctions or by attaching drugs to one of the existing transport systems. Either way, access must specifically allow only the passage of a particular drug. In general, the BBB allows small molecules to enter the CNS; however, most drugs with the potential to treat neurological disorders other than infections have large structures. Several mechanisms, such as modifications of the built-in pumping-out system of drugs and utilization of nanocarriers and liposomes, are among the drug-delivery systems that have been tested; however, each has its limitations and constraints. This review comprehensively discusses the functional morphology of the BBB and the challenges that must be overcome by drug-delivery systems and elaborates on the potential targets, mechanisms, and formulations to improve drug delivery to the CNS.

  8. High-resolution reconstruction of a coastal barrier system

    DEFF Research Database (Denmark)

    Fruergaard, Mikkel; Andersen, Thorbjørn Joest; Nielsen, Lars Henrik

    2015-01-01

    from retreat of the barrier island and probably also due to formation of a tidal inlet close to the study area. Continued transgression and shoreface retreat created a distinct hiatus and wave ravinement surface in the seaward part of the CBS before the barrier shoreline stabilised between 5.0 and 4.......5 ka ago. Back-barrier shoreline erosion due to sediment starvation in the back-barrier basin, was pronounced from 4.5 to 2.5 ka ago but the last 2.5 kyr barrier sedimentation has kept up with and outpaced sea-level. The last 0.4 kyr the CBS has been episodically prograding. Sediment accumulation shows...

  9. Genetic architecture of a reinforced, postmating, reproductive isolation barrier between Neurospora species indicates evolution via natural selection.

    Directory of Open Access Journals (Sweden)

    Elizabeth Turner

    2011-08-01

    Full Text Available A role for natural selection in reinforcing premating barriers is recognized, but selection for reinforcement of postmating barriers remains controversial. Organisms lacking evolvable premating barriers can theoretically reinforce postmating isolation, but only under restrictive conditions: parental investment in hybrid progeny must inhibit subsequent reproduction, and selected postmating barriers must restore parents' capacity to reproduce successfully. We show that reinforced postmating isolation markedly increases maternal fitness in the fungus Neurospora crassa, and we detect the evolutionary genetic signature of natural selection by quantitative trait locus (QTL analysis of the reinforced barrier. Hybrid progeny of N. crassa and N. intermedia are highly inviable. Fertilization by local N. intermedia results in early abortion of hybrid fruitbodies, and we show that abortion is adaptive because only aborted maternal colonies remain fully receptive to future reproduction. In the first QTL analysis of postmating reinforcement in microbial eukaryotes, we identify 11 loci for abortive hybrid fruitbody development, including three major QTLs that together explain 30% of trait variance. One of the major QTLs and six QTLs of lesser effect are found on the mating-type determining chromosome of Neurospora. Several reinforcement QTLs are flanked by genetic markers showing either segregation distortion or non-random associations with alleles at other loci in a cross between N. crassa of different clades, suggesting that the loci also are associated with local effects on same-species reproduction. Statistical analysis of the allelic effects distribution for abortive hybrid fruitbody development indicates its evolution occurred under positive selection. Our results strongly support a role for natural selection in the evolution of reinforced postmating isolation in N. crassa.

  10. The Mechanisms and Quantification of the Selective Permeability in Transport Across Biological Barriers : the Example of Kyotorphin

    NARCIS (Netherlands)

    Serrano, Isa D.; Freire, Joao M.; Carvalho, Miguel V.; Neves, Mafalda; Melo, Manuel N.; Castanho, Miguel A. R. B.

    2014-01-01

    This paper addresses the mechanisms behind selective endothelial permeability and their regulations. The singular properties of each of the seven blood-tissues barriers. Then, it further revisits the physical, quantitative meaning of permeability, and the way it should be measured based on sound phy

  11. Modelled in vivo HIV fitness under drug selective pressure and estimated genetic barrier towards resistance are predictive for virological response

    DEFF Research Database (Denmark)

    Deforche, Koen; Cozzi-Lepri, Alessandro; Theys, Kristof

    2008-01-01

    BACKGROUND: A method has been developed to estimate a fitness landscape experienced by HIV-1 under treatment selective pressure as a function of the genotypic sequence thereby also estimating the genetic barrier to resistance. METHODS: We evaluated the performance of two estimated fitness landsca...

  12. The advantages and barriers in the implementation of a substance dependence treatment information system (SDTIS).

    Science.gov (United States)

    Ajami, Sima; Mellat-Karkevandi, Zahra

    2015-11-01

    Addiction is a phenomenon that causes structural changes in different systems of society. Studies show for planning of addiction prevention and treatment, it is necessary to create an information management system. Substance dependence information systems refer to systems which collect, analyse and report data related to substance dependence information. The aim of this study was to identify advantages and barriers to implement Substance Dependence Treatment Information System (SDTIS). This study was a narrative review. Our review divided into three phases: literature collection, assessing, and selection. We employed the following keywords and their combinations in different areas of articles. In this study, 22 of collected articles and reports were selected based on their relevancy. We found many advantages for a substance dependence treatment information system such as recording sufficient, complete and accurate information and easy and timely access to them and monitoring and enhancing the quality of care received by patients. But we may face some concerns for implementing this information system like taking time and funds from client services, being expensive or even problems regarding the quality of data contained in these information systems. There are some important problems in the way of implementing. In order to overcome these issues, we need to raise community awareness.

  13. The advantages and barriers in the implementation of a substance dependence treatment information system (SDTIS

    Directory of Open Access Journals (Sweden)

    Sima Ajami

    2015-01-01

    Full Text Available Addiction is a phenomenon that causes structural changes in different systems of society. Studies show for planning of addiction prevention and treatment, it is necessary to create an information management system. Substance dependence information systems refer to systems which collect, analyse and report data related to substance dependence information. The aim of this study was to identify advantages and barriers to implement Substance Dependence Treatment Information System (SDTIS. This study was a narrative review. Our review divided into three phases: literature collection, assessing, and selection. We employed the following keywords and their combinations in different areas of articles. In this study, 22 of collected articles and reports were selected based on their relevancy. We found many advantages for a substance dependence treatment information system such as recording sufficient, complete and accurate information and easy and timely access to them and monitoring and enhancing the quality of care received by patients. But we may face some concerns for implementing this information system like taking time and funds from client services, being expensive or even problems regarding the quality of data contained in these information systems. There are some important problems in the way of implementing. In order to overcome these issues, we need to raise community awareness.

  14. Science and business cooperation. Barriers in Poland within the context of selected European and North American countries

    Directory of Open Access Journals (Sweden)

    Dariusz Trzmielak

    2015-12-01

    Full Text Available This article focuses on the theoretical and empirical analysis of factors affecting the cooperation between science and business. The author will present the results of empirical research conducted in Poland, the Czech Republic, Hungary, France, Norway, the United States of America and Canada. The analysis will indicate how and which factors: structural, systemic, competence or awareness and cultural can be utilised in the commercialisation of knowledge and technologies. The analysis of research outcomes which underpins this study is also set on the following assumptions: Every country has different barriers to cooperation between scientists and entrepreneurs; Polish scientists and entrepreneurs should rely on proven and significant factors conducive to cooperation between science and business in Poland; Academic centres in Poland can benefit from the experience gained by other countries to intensify its model of cooperation with entrepreneurs. The article will showcase the research results that relate to the identification of selected problems occurring in establishing and maintaining cooperation between Polish scientific research organisations and entrepreneurs in the context of selected countries whose respondents were subject to empirical research.

  15. A Selection Method for COTS Systems

    DEFF Research Database (Denmark)

    Hedman, Jonas

    Historically, organizations developed their information systems in-house. Today, a large portion of information systems development is based on acquisition of pre-made information systems, so called commercially off the shelf (COTS) systems. This approach of developing information systems requires...... new skills and methods supporting the process of evaluating and selecting information systems. This paper presents a method for selecting COTS systems. The method includes the following phases: problem framing, requirements and appraisal, and selection of systems. The idea and distinguishing feature...... the selection of COTS systems as viewing COTS systems as a ‘mean' to reach organizational ‘ends' is different from the mainstream view of information systems development, which view information systems development as a problem solving process, and the underlying ontological view in other COTS selection methods...

  16. MERCURY OXIDIZATION IN NON-THERMAL PLASMA BARRIER DISCHARGE SYSTEM

    Energy Technology Data Exchange (ETDEWEB)

    V.K. Mathur

    2003-02-01

    In the past decade, the emission of toxic elements from human activities has become a matter of great public concern. Hg, As, Se and Cd typically volatilize during a combustion process and are not easily caught with conventional air pollution control techniques. In addition, there is no pollution prevention technique available now or likely be available in the foreseeable future that can prevent the emission of these trace elements. These trace elements pose additional scientific challenge as they are present at only ppb levels in large gas streams. Mercury, in particular, has attracted significant attention due to its high volatility, toxicity and potential threat to human health. In the present research work, a non-thermal plasma dielectric barrier discharge technique has been used to oxidize Hg{sup 0}(g) to HgO. The basic premise of this approach is that Hg{sup 0} in vapor form cannot be easily removed in an absorption tower whereas HgO as a particulate is amiable to water scrubbing. The work presented in this report consists of three steps: (1) setting-up of an experimental apparatus to generate mercury vapors at a constant rate and modifying the existing non-thermal plasma reactor system, (2) solving the analytical challenge for measuring mercury vapor concentration at ppb level, and (3) conducting experiments on mercury oxidation under plasma conditions to establish proof of concept.

  17. Selective disruption of the blood-brain barrier by photochemical internalization

    Science.gov (United States)

    Hirschberg, Henry; Zhang, Michelle J.; Gach, Michael H.; Uzal, Francisco A.; Chighvinadze, David; Madsen, Steen J.

    2009-02-01

    Introduction: Failure to eradicate infiltrating glioma cells using conventional treatment regimens results in tumor recurrence and is responsible for the dismal prognosis of patients with glioblastoma multiforme (GBM). This is due to the fact that these migratory cells are protected by the blood-brain barrier (BBB) which prevents the delivery of most anti-cancer agents. We have evaluated the ability of photochemical internalization (PCI) to selectively disrupt the BBB in rats. This will permit access of anti-cancer drugs to effectively target the infiltrating tumor cells, and potentially improve the treatment effectiveness for malignant gliomas. Materials and Methods: PCI treatment, coupling a macromolecule therapy of Clostridium perfringens (Cl p) epsilon prototoxin with AlPcS2a-PDT, was performed on non-tumor bearing inbred Fisher rats. T1-weighted post-contrast magnetic resonance imaging (MRI) scans were used to evaluate the extent of BBB disruption which can be inferred from the volume contrast enhancement. Results: The synergistic effect of PCI to disrupt the BBB was observed at a fluence level of 1 J with an intraperitoneal injection of Cl p prototoxin. At the fluence level of 2.5J, the extent of BBB opening induced by PCI was similar to the result of PDT suggesting no synergistic effect evoked under these conditions. Conclusion: PCI was found to be highly effective and efficient for inducing selective and localized disruption of the BBB. The extent of BBB opening peaked on day 3 and the BBB was completed restored by day 18 post treatment.

  18. ARCTIC FOUNDATIONS, INC. FREEZE BARRIER SYSTEM - SITE TECHNOLOGY CAPSULE

    Science.gov (United States)

    Arctic Foundations, Inc. (AFI), of Anchorage, Alaska has developed a freeze barrier technology designed to prevent the migration of contaminants in groundwater by completely isolating contaminant source areas until appropriate remediation techniques can be applied. With this tec...

  19. Sports selection system in triathlon

    Directory of Open Access Journals (Sweden)

    Volodymyr Vodlozerov

    2016-06-01

    Full Text Available Purpose: to analyze the contents of the main stages of sports selection of triathletes. Material & Methods: study and generalization of special literature on the issue of sports selection in continuous triathlon, analysis of triathletes selection based on normative documents. Results: there were reviewed the particularities of sports selection of triathletes on each of its main stages and the role of heredity as a necessary condition for practicing sports for endurance, and also there was shown the procedure of calculation of rating points. Conclusions: sports selection plays a key role in the admission of pupils to the departments of triathlon in sports schools as well as in the formation of picked teams of all levels for participation in competitions on continuous triathlon.

  20. Selective HDAC6 inhibition prevents TNF-α-induced lung endothelial cell barrier disruption and endotoxin-induced pulmonary edema.

    Science.gov (United States)

    Yu, Jinyan; Ma, Zhongsen; Shetty, Sreerama; Ma, Mengshi; Fu, Jian

    2016-07-01

    Lung endothelial damage contributes to the pathogenesis of acute lung injury. New strategies against lung endothelial barrier dysfunction may provide therapeutic benefits against lung vascular injury. Cell-cell junctions and microtubule cytoskeleton are basic components in maintaining endothelial barrier integrity. HDAC6, a deacetylase primarily localized in the cytoplasm, has been reported to modulate nonnuclear protein function through deacetylation. Both α-tubulin and β-catenin are substrates for HDAC6. Here, we examined the effects of tubastatin A, a highly selective HDAC6 inhibitor, on TNF-α induced lung endothelial cell barrier disruption and endotoxin-induced pulmonary edema. Selective HDAC6 inhibition by tubastatin A blocked TNF-α-induced lung endothelial cell hyperpermeability, which was associated with increased α-tubulin acetylation and microtubule stability. Tubastatin A pretreatment inhibited TNF-α-induced endothelial cell contraction and actin stress fiber formation with reduced myosin light chain phosphorylation. Selective HDAC6 inhibition by tubastatin A also induced β-catenin acetylation in human lung endothelial cells, which was associated with increased membrane localization of β-catenin and stabilization of adherens junctions. HDAC6 knockdown by small interfering RNA also prevented TNF-α-induced barrier dysfunction and increased α-tubulin and β-catenin acetylation in endothelial cells. Furthermore, in a mouse model of endotoxemia, tubastatin A was able to prevent endotoxin-induced deacetylation of α-tubulin and β-catenin in lung tissues, which was associated with reduced pulmonary edema. Collectively, our data indicate that selective HDAC6 inhibition by tubastatin A is a potent approach against lung endothelial barrier dysfunction.

  1. Advanced Oxide Material Systems for 1650 C Thermal/Environmental Barrier Coating Applications

    Science.gov (United States)

    Zhu, Dong-Ming; Fox, Dennis S.; Bansal, Narottam P.; Miller, Robert A.

    2004-01-01

    Advanced thermal and environmental barrier coatings (TEBCs) are being developed for low-emission SiC/SiC ceramic matrix composite (CMC) combustor and vane applications to extend the CMC liner and vane temperature capability to 1650 C (3000 F) in oxidizing and water-vapor-containing combustion environments. The advanced 1650 C TEBC system is required to have a better high-temperature stability, lower thermal conductivity, and more resistance to sintering and thermal stress than current coating systems under engine high-heat-flux and severe thermal cycling conditions. In this report, the thermal conductivity and water vapor stability of selected candidate hafnia-, pyrochlore- and magnetoplumbite-based TEBC materials are evaluated. The effects of dopants on the materials properties are also discussed. The test results have been used to downselect the TEBC materials and help demonstrate the feasibility of advanced 1650 C coatings with long-term thermal cycling durability.

  2. Design of noise barrier inspection system for high-speed railway

    Science.gov (United States)

    Liu, Bingqian; Shao, Shuangyun; Feng, Qibo; Ma, Le; Cholryong, Kim

    2016-10-01

    The damage of noise barriers will highly reduce the transportation safety of the high-speed railway. In this paper, an online inspection system of noise barrier based on laser vision for the safety of high-speed railway is proposed. The inspection system, mainly consisted of a fast camera and a line laser, installed in the first carriage of the high-speed CIT(Composited Inspection Train).A Laser line was projected on the surface of the noise barriers and the images of the light line were received by the camera while the train is running at high speed. The distance between the inspection system and the noise barrier can be obtained based on laser triangulation principle. The results of field tests show that the proposed system can meet the need of high speed and high accuracy to get the contour distortion of the noise barriers.

  3. Materials Selection for Aerospace Systems

    Science.gov (United States)

    Arnold, Steven M.; Cebon, David; Ashby, Mike

    2012-01-01

    A systematic design-oriented, five-step approach to material selection is described: 1) establishing design requirements, 2) material screening, 3) ranking, 4) researching specific candidates and 5) applying specific cultural constraints to the selection process. At the core of this approach is the definition performance indices (i.e., particular combinations of material properties that embody the performance of a given component) in conjunction with material property charts. These material selection charts, which plot one property against another, are introduced and shown to provide a powerful graphical environment wherein one can apply and analyze quantitative selection criteria, such as those captured in performance indices, and make trade-offs between conflicting objectives. Finding a material with a high value of these indices maximizes the performance of the component. Two specific examples pertaining to aerospace (engine blades and pressure vessels) are examined, both at room temperature and elevated temperature (where time-dependent effects are important) to demonstrate the methodology. The discussion then turns to engineered/hybrid materials and how these can be effectively tailored to fill in holes in the material property space, so as to enable innovation and increases in performance as compared to monolithic materials. Finally, a brief discussion is presented on managing the data needed for materials selection, including collection, analysis, deployment, and maintenance issues.

  4. Isolation gowns in health care settings: Laboratory studies, regulations and standards, and potential barriers of gown selection and use

    Science.gov (United States)

    Kilinc Balci, F. Selcen

    2016-01-01

    Although they play an important role in infection prevention and control, textile materials and personal protective equipment (PPE) used in health care settings are known to be one of the sources of cross-infection. Gowns are recommended to prevent transmission of infectious diseases in certain settings; however, laboratory and field studies have produced mixed results of their efficacy. PPE used in health care is regulated as either class I (low risk) or class II (intermediate risk) devices in the United States. Many organizations have published guidelines for the use of PPE, including isolation gowns, in health care settings. In addition, the Association for the Advancement of Medical Instrumentation published a guidance document on the selection of gowns and a classification standard on liquid barrier performance for both surgical and isolation gowns. However, there is currently no existing standard specific to isolation gowns that considers not only the barrier resistance but also a wide array of end user desired attributes. As a result, infection preventionists and purchasing agents face several difficulties in the selection process, and end users have limited or no information on the levels of protection provided by isolation gowns. Lack of knowledge about the performance of protective clothing used in health care became more apparent during the 2014 Ebola epidemic. This article reviews laboratory studies, regulations, guidelines and standards pertaining to isolation gowns, characterization problems, and other potential barriers of isolation gown selection and use. PMID:26391468

  5. Disposal systems evaluations and tool development : Engineered Barrier System (EBS) evaluation.

    Energy Technology Data Exchange (ETDEWEB)

    Rutqvist, Jonny (LBNL); Liu, Hui-Hai (LBNL); Steefel, Carl I. (LBNL); Serrano de Caro, M. A. (LLNL); Caporuscio, Florie Andre (LANL); Birkholzer, Jens T. (LBNL); Blink, James A. (LLNL); Sutton, Mark A. (LLNL); Xu, Hongwu (LANL); Buscheck, Thomas A. (LLNL); Levy, Schon S. (LANL); Tsang, Chin-Fu (LBNL); Sonnenthal, Eric (LBNL); Halsey, William G. (LLNL); Jove-Colon, Carlos F.; Wolery, Thomas J. (LLNL)

    2011-01-01

    Key components of the nuclear fuel cycle are short-term storage and long-term disposal of nuclear waste. The latter encompasses the immobilization of used nuclear fuel (UNF) and radioactive waste streams generated by various phases of the nuclear fuel cycle, and the safe and permanent disposition of these waste forms in geological repository environments. The engineered barrier system (EBS) plays a very important role in the long-term isolation of nuclear waste in geological repository environments. EBS concepts and their interactions with the natural barrier are inherently important to the long-term performance assessment of the safety case where nuclear waste disposition needs to be evaluated for time periods of up to one million years. Making the safety case needed in the decision-making process for the recommendation and the eventual embracement of a disposal system concept requires a multi-faceted integration of knowledge and evidence-gathering to demonstrate the required confidence level in a deep geological disposal site and to evaluate long-term repository performance. The focus of this report is the following: (1) Evaluation of EBS in long-term disposal systems in deep geologic environments with emphasis on the multi-barrier concept; (2) Evaluation of key parameters in the characterization of EBS performance; (3) Identification of key knowledge gaps and uncertainties; and (4) Evaluation of tools and modeling approaches for EBS processes and performance. The above topics will be evaluated through the analysis of the following: (1) Overview of EBS concepts for various NW disposal systems; (2) Natural and man-made analogs, room chemistry, hydrochemistry of deep subsurface environments, and EBS material stability in near-field environments; (3) Reactive Transport and Coupled Thermal-Hydrological-Mechanical-Chemical (THMC) processes in EBS; and (4) Thermal analysis toolkit, metallic barrier degradation mode survey, and development of a Disposal Systems

  6. Barriers to Mitigate Carbon Footprint in a Selected Academic Institution in Bacoor City, Cavite, Philippines

    Science.gov (United States)

    Adanza, Jonathan R.

    2016-01-01

    Carbon footprint is an environmental menace that needs to be addressed at once. Various mitigating measures were proposed and yet manifestations of its proliferation are very much observable. This study seeks to determine primarily the barriers of non-adherence to identified measures to mitigate carbon footprint in the environment. Using the mixed…

  7. Barriers and opportunities: A review of selected successful energy-efficiency programs

    Energy Technology Data Exchange (ETDEWEB)

    Worrell, Ernst; Price, Lynn

    2001-03-20

    In industry, barriers may exist at various points in the decision making process, and in the implementation and management of measures to improve energy efficiency. Barriers may take many forms, and are determined by the business environment and include decision-making processes, energy prices, lack of information, a lack of confidence in the information, or high transaction costs for obtaining reliable information, as well as limited capital availability. Other barriers are the ''invisibility'' of energy efficiency measures and the difficulty of quantifying the impacts, and slow diffusion of innovative technology into markets while firms typically under-invest in R and D, despite the high pay-backs. Various programs try to reduce the barriers to improve the uptake of innovative technologies. A wide array of policies has been used and tested in the industrial sector in industrialized countries, with varying success rates. We review some new approaches to industrial energy efficiency improvement in industrialized countries, focusing on voluntary agreements.

  8. Expert System Model for Educational Personnel Selection

    Directory of Open Access Journals (Sweden)

    Héctor A. Tabares-Ospina

    2013-06-01

    Full Text Available The staff selection is a difficult task due to the subjectivity that the evaluation means. This process can be complemented using a system to support decision. This paper presents the implementation of an expert system to systematize the selection process of professors. The management of software development is divided into 4 parts: requirements, design, implementation and commissioning. The proposed system models a specific knowledge through relationships between variables evidence and objective.

  9. CHARACTERIZATION OF BENTONITE FOR ENGINEERED BARRIER SYSTEMS IN RADIOACTIVE WASTE DISPOSAL SITES

    Directory of Open Access Journals (Sweden)

    Dubravko Domitrović

    2012-07-01

    Full Text Available Engineered barrier systems are used in radioactive waste disposal sites in order to provide better protection of humans and the environment from the potential hazards associated with the radioactive waste disposal. The engineered barrier systems usually contain cement or clay (bentonite because of their isolation properties and long term performance. Quality control tests of clays are the same for all engineering barrier systems. Differences may arise in the required criteria to be met due for different application. Prescribed clay properties depend also on the type of host rocks. This article presents radioactive waste management based on best international practice. Standard quality control procedures for bentonite used as a sealing barrier in radioactive waste disposal sites are described as some personal experiences and results of the index tests (free swelling index, water adsorption capacity, plasticity limits and hydraulic permeability of bentonite (the paper is published in Croatian.

  10. Selective ablation of the androgen receptor in mouse sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development.

    Directory of Open Access Journals (Sweden)

    Ariane Willems

    Full Text Available The observation that mice with a selective ablation of the androgen receptor (AR in Sertoli cells (SC (SCARKO mice display a complete block in meiosis supports the contention that SC play a pivotal role in the control of germ cell development by androgens. To delineate the physiological and molecular mechanism responsible for this control, we compared tubular development in pubertal SCARKO mice and littermate controls. Particular attention was paid to differences in SC maturation, SC barrier formation and cytoskeletal organization and to the molecular mediators potentially involved. Functional analysis of SC barrier development by hypertonic perfusion and lanthanum permeation techniques and immunohistochemical analysis of junction formation showed that SCARKO mice still attempt to produce a barrier separating basal and adluminal compartment but that barrier formation is delayed and defective. Defective barrier formation was accompanied by disturbances in SC nuclear maturation (immature shape, absence of prominent, tripartite nucleoli and SC polarization (aberrant positioning of SC nuclei and cytoskeletal elements such as vimentin. Quantitative RT-PCR was used to study the transcript levels of genes potentially related to the described phenomena between day 8 and 35. Differences in the expression of SC genes known to play a role in junction formation could be shown from day 8 for Cldn11, from day 15 for Cldn3 and Espn, from day 20 for Cdh2 and Jam3 and from day 35 for ZO-1. Marked differences were also noted in the transcript levels of several genes that are also related to cell adhesion and cytoskeletal dynamics but that have not yet been studied in SC (Actn3, Ank3, Anxa9, Scin, Emb, Mpzl2. It is concluded that absence of a functional AR in SC impedes the remodeling of testicular tubules expected at the onset of spermatogenesis and interferes with the creation of the specific environment needed for germ cell development.

  11. Reactive barrier system for nitrate removal from mine effluents in northern Sweden: Laboratory experiments

    Science.gov (United States)

    Herbert, Roger

    2010-05-01

    Laboratory column experiments have been conducted to determine nitrate removal rates from mine effluents by denitrification, with the purpose of providing initial data for the construction of a pilot scale reactive barrier system at the Malmberget iron mine, Sweden. Experiments were conducted at several different flow rates at 5C, 10C and room temperature; annual mean temperatures at the Malmberget site lie close to 0C. Columns were filled with an organic substrate consisting of sawdust mixed with sewage sludge, the source of denitrifying bacteria, supported by oven-dried clay pellets. Apparent denitrification rates, calculated from inflow and outflow nitrate concentrations and column hydraulic residence time, ranged from 5 to 13 mg N/L/d, with the lowest rates corresponding to the 5C experiments. These rates are, however, limited to a certain degree by the low flow rate and the supply of electrons acceptors (i.e. nitrate) to denitrifying bacteria. Results from the column experiment have been used to construct a barrier system in Malmberget, Sweden. Trial runs with the pilot-scale barrier will be conducted during 2010, with the purpose of determining the performance of the barrier as mean air temperatures increase from below to above 0C and saturated flow commences in the barrier. The barrier system is constructed as a rectangular container with steel sheet walls (9m length in flow direction, 1.5m deep), and the flow rate will be adjusted to a hydraulic residence time of 1 day. The pilot-scale barrier system currently lies above ground, but a permanent barrier system would be installed below the ground surface so that the system can be maintained at positive temperatures throughout the year.

  12. Control Configuration Selection for Multivariable Descriptor Systems

    DEFF Research Database (Denmark)

    Shaker, Hamid Reza; Stoustrup, Jakob

    2012-01-01

    is needed to be controlled, is either in the descriptor form or can be represented in the descriptor form. Singular systems and the differential algebraic equation (DAE) systems are among these systems. Descriptor systems appear in the variety of fields to describe the practical processes ranging from power...... systems, hydraulic systems to heat transfer, and chemical processes. The focus of this paper is on the problem of control configuration selection for multivariable descriptor systems. A gramian-based interaction measure for control configuration selection of such processes is described in this paper....... The proposed MIMO interaction measure is the extension of its gramian-based analogous counterpart, which has been proposed for the input–output pairing as well as for the controller architecture selection of the processes with the standard state-space form. The main advantage of this interaction measure...

  13. An investigation of enhanced capability thermal barrier coating systems for diesel engine components

    Science.gov (United States)

    Holtzman, R. L.; Layne, J. L.; Schechter, B.

    1984-01-01

    Material systems and processes for the development of effective and durable thermal barriers for heavy duty diesel engines were investigated. Seven coating systems were evaluated for thermal conductivity, erosion resistance, corrosion/oxidation resistance, and thermal shock resistance. An advanced coating system based on plasma sprayed particle yttria stabilized zirconia (PS/HYSZ) was judged superior in these tests. The measured thermal conductivity of the selected coating was 0.893 W/m C at 371 C. The PS/HYSZ coating system was applied to the piston crown, fire deck and valves of a single cylinder low heat rejection diesel engine. The coated engine components were tested for 24 hr at power levels from 0.83 MPa to 1.17 MPa brake mean effective pressure. The component coatings survived the engine tests with a minimum of distress. The measured fire deck temperatures decreased 86 C (155 F) on the intake side and 42 C (75 F) on the exhaust side with the coating applied.

  14. Regulation of Copper Transport Crossing Brain Barrier Systems by Cu-ATPases: Effect of Manganese Exposure

    OpenAIRE

    Fu, Xue; Zhang, Yanshu; Jiang, Wendy; Monnot, Andrew Donald; Bates, Christopher Alexander; Zheng, Wei

    2014-01-01

    Regulation of cellular copper (Cu) homeostasis involves Cu-transporting ATPases (Cu-ATPases), i.e., ATP7A and ATP7B. The question as to how these Cu-ATPases in brain barrier systems transport Cu, i.e., toward brain parenchyma, cerebrospinal fluid (CSF), or blood, remained unanswered. This study was designed to characterize roles of Cu-ATPases in regulating Cu transport at the blood-brain barrier (BBB) and blood-CSF barrier (BCB) and to investigate how exposure to toxic manganese (Mn) altered ...

  15. Advances in the Dynallax solid-state dynamic parallax barrier autostereoscopic visualization display system.

    Energy Technology Data Exchange (ETDEWEB)

    Peterka, T.; Kooima, R. L.; Sandin, D. J.; Johnson, A.; Leigh, J.; DeFanti, T. A.; Mathematics and Computer Science; Univ. of Illinois at Chicago; Univ. of Calif. at San Diego

    2008-05-01

    A solid-state dynamic parallax barrier autostereoscopic display mitigates some of the restrictions present in static barrier systems such as fixed view-distance range, slow response to head movements, and fixed stereo operating mode. By dynamically varying barrier parameters in real time, viewers may move closer to the display and move faster laterally than with a static barrier system, and the display can switch between 3D and 2D modes by disabling the barrier on a per-pixel basis. Moreover, Dynallax can output four independent eye channels when two viewers are present, and both head-tracked viewers receive an independent pair of left-eye and right-eye perspective views based on their position in 3D space. The display device is constructed by using a dual-stacked LCD monitor where a dynamic barrier is rendered on the front display and a modulated virtual environment composed of two or four channels is rendered on the rear display. Dynallax was recently demonstrated in a small-scale head-tracked prototype system. This paper summarizes the concepts presented earlier, extends the discussion of various topics, and presents recent improvements to the system.

  16. Advances in the Dynallax solid-state dynamic parallax barrier autostereoscopic visualization display system.

    Science.gov (United States)

    Peterka, Tom; Kooima, Robert L; Sandin, Daniel J; Johnson, Andrew; Leigh, Jason; DeFanti, Thomas A

    2008-01-01

    A solid-state dynamic parallax barrier autostereoscopic display mitigates some of the restrictions present in static barrier systems, such as fixed view-distance range, slow response to head movements, and fixed stereo operating mode. By dynamically varying barrier parameters in real time, viewers may move closer to the display and move faster laterally than with a static barrier system, and the display can switch between 3D and 2D modes by disabling the barrier on a per-pixel basis. Moreover, Dynallax can output four independent eye channels when two viewers are present, and both head-tracked viewers receive an independent pair of left-eye and right-eye perspective views based on their position in 3D space. The display device is constructed by using a dual-stacked LCD monitor where a dynamic barrier is rendered on the front display and a modulated virtual environment composed of two or four channels is rendered on the rear display. Dynallax was recently demonstrated in a small-scale head-tracked prototype system. This paper summarizes the concepts presented earlier, extends the discussion of various topics, and presents recent improvements to the system.

  17. Investigation of endothelial growth using a sensors-integrated microfluidic system to simulate physiological barriers

    Directory of Open Access Journals (Sweden)

    Rajabi Taleieh

    2015-09-01

    Full Text Available In this paper we present a microfluidic system based on transparent biocompatible polymers with a porous membrane as substrate for various cell types which allows the simulation of various physiological barriers under continuous laminar flow conditions at distinct tunable shear rates. Besides live cell and fluorescence microscopy, integrated electrodes enable the investigation of the permeability and barrier function of the cell layer as well as their interaction with external manipulations using the Electric Cell-substrate Impedance Sensing (ECIS method.

  18. Perceptions of physicians about knowledge sharing barriers in Turkish health care system.

    Science.gov (United States)

    Gider, Ömer; Ocak, Saffet; Top, Mehmet

    2015-05-01

    This study was based on knowledge sharing barriers about attitudes of physicians in Turkish health care system. The present study aims to determine whether the knowledge sharing barriers about attitudes of physicians vary depending on gender, position, departments at hospitals, and hospital ownership status. This study was planned and conducted on physicians at one public hospital, one university hospital, and one private hospital in Turkey. 209 physicians were reached for data collection. The study was conducted in June-September 2014. The questionnaire (developed by A. Riege, (J. Knowl. Manag. 9(3):18-35, 2005)), five point Likert-type scale including 39 items having the potential of the physicians' knowledge- sharing attitudes and behaviors, was used in the study for data collection. Descriptive statistics, reliability analysis, student t test and ANOVA were used for data analysis. According to results of this study, there was medium level of knowledge sharing barriers within hospitals. In general, physicians had perceptions about the lowest level individual barriers, intermediate level organizational barriers and the highest level technological barriers perceptions, respectively. This study revealed that some knowledge sharing barriers about attitudes of physicians were significantly difference according to hospital ownership status, gender, position and departments. Most evidence medical decisions and evidence based practice depend on experience and knowledge of existing options and knowledge sharing in health care organizations. Physicians are knowledge and information-intensive and principal professional group in health care context.

  19. Noncontacting Laser Inspection System for Dimensional Profiling of Space Application Thermal Barriers

    Science.gov (United States)

    Taylor, Shawn C.

    2011-01-01

    A noncontacting, two-dimensional (2-D) laser inspection system has been designed and implemented to dimensionally profile thermal barriers being developed for space vehicle applications. In a vehicle as-installed state, thermal barriers are commonly compressed between load sensitive thermal protection system (TPS) panels to prevent hot gas ingestion through the panel interface during flight. Loads required to compress the thermal barriers are functions of their construction, as well as their dimensional characteristics relative to the gaps in which they are installed. Excessive loads during a mission could damage surrounding TPS panels and have catastrophic consequences. As such, accurate dimensional profiling of thermal barriers prior to use is important. Due to the compliant nature of the thermal barriers, traditional contact measurement techniques (e.g., calipers and micrometers) are subjective and introduce significant error and variability into collected dimensional data. Implementation of a laser inspection system significantly enhanced the method by which thermal barriers are dimensionally profiled, and improved the accuracy and repeatability of collected data. A statistical design of experiments study comparing laser inspection and manual caliper measurement techniques verified these findings.

  20. Natural selection drives Drosophila immune system evolution.

    Science.gov (United States)

    Schlenke, Todd A; Begun, David J

    2003-08-01

    Evidence from disparate sources suggests that natural selection may often play a role in the evolution of host immune system proteins. However, there have been few attempts to make general population genetic inferences on the basis of analysis of several immune-system-related genes from a single species. Here we present DNA polymorphism and divergence data from 34 genes thought to function in the innate immune system of Drosophila simulans and compare these data to those from 28 nonimmunity genes sequenced from the same lines. Several statistics, including average K(A)/K(S) ratio, average silent heterozygosity, and average haplotype diversity, significantly differ between the immunity and nonimmunity genes, suggesting an important role for directional selection in immune system protein evolution. In contrast to data from mammalian immunoglobulins and other proteins, we find no strong evidence for the selective maintenance of protein diversity in Drosophila immune system proteins. This may be a consequence of Drosophila's generalized innate immune response.

  1. Effect of vadose zone on the steady-state leakage rates from landfill barrier systems.

    Science.gov (United States)

    Celik, B; Rowe, R K; Unlü, K

    2009-01-01

    Leakage rates are evaluated for a landfill barrier system having a compacted clay liner (CCL) underlain by a vadose zone of variable thickness. A numerical unsaturated flow model SEEP/W is used to simulate the moisture flow regime and steady-state leakage rates for the cases of unsaturated zones with different soil types and thicknesses. The results of the simulations demonstrate that harmonic mean hydraulic conductivity of coarse textured vadose zones is 3-4 orders of magnitude less than saturated hydraulic conductivity; whereas, the difference is only one order of magnitude for fine textured vadose zones. For both coarse and fine textured vadose zones, the effective hydraulic conductivity of the barrier system and the leakage rate to an underlying aquifer increases with increasing thickness of the vadose zone and ultimately reaches an asymptotic value for a coarse textured vadose zone thickness of about 10m and a fine textured vadose zone thickness of about 5m. Therefore, the fine and coarse textured vadose zones thicker than about 5m and 10m, respectively, act as an effective part of the barrier systems examined. Although the thickness of vadose zone affects the effective hydraulic conductivity of the overall barrier system, the results demonstrated that the hydraulic conductivity of the CCL is the dominant factor controlling the steady-state leakage rates through barrier systems having single low permeability clay layers.

  2. Multiuser hybrid switched-selection diversity systems

    KAUST Repository

    Shaqfeh, Mohammad

    2011-09-01

    A new multiuser scheduling scheme is proposed and analyzed in this paper. The proposed system combines features of conventional full-feedback selection-based diversity systems and reduced-feedback switch-based diversity systems. The new hybrid system provides flexibility in trading-off the channel information feedback overhead with the prospected multiuser diversity gains. The users are clustered into groups, and the users\\' groups are ordered into a sequence. Per-group feedback thresholds are used and optimized to maximize the system overall achievable rate. The proposed hybrid system applies switched diversity criterion to choose one of the groups, and a selection criterion to decide the user to be scheduled from the chosen group. Numerical results demonstrate that the system capacity increases as the number of users per group increases, but at the cost of more required feedback messages. © 2011 IEEE.

  3. The Hybridization Barrier between Herbaceous Medicago sativa and Woody M. arborea Is Weakened by Selection of Seed Parents

    Directory of Open Access Journals (Sweden)

    Edwin Bingham

    2013-05-01

    Full Text Available Medicago sativa, alfalfa or lucerne, and M. arborea were considered reproductively isolated until recently. Then, in 2003, an alfalfa genotype was identified that produced a few seeds and progeny with hybrid traits after a large number of pollinations by M. arborea. A derivative of this alfalfa genotype also produced a low frequency of progeny with hybrid traits. Thus, the hybridization barrier was weakened by selection of seed parents. Hybrids from both events expressed traits from M. arborea and M. arborea-specific DNA bands, although more of the M. sativa genome was retained, based on the DNA results. Thus, there was chromatin elimination during embryogenesis, resulting in partial hybrids (hereafter hybrids. However, more than 30 hybrids with an array of M. arborea traits have been obtained thus far, and research continues on the nature of the hybrids. Traits have been genetically transmitted in crosses, and selected traits are in use for alfalfa breeding. This paper reviews the first hybrids and then focuses on further weakening of the hybridization barrier with the discovery of a more efficient hybridizer derived from crossing Medicago sativa subspecies, sativa, coerulea and falcata. This genotype was found to have reproductive abnormalities associated with its complex subspecies origin that are best described as hybrid breakdown. In effect, this subspecies derivative is a bridge-cross parent that consistently produces hybrids. Reproductive abnormalities in the bridge-cross parent are reported and discussed.

  4. Effect of joint mechanism on vehicle redirectional capability of water-filled road safety barrier systems.

    Science.gov (United States)

    Thiyahuddin, M I; Thambiratnam, D P; Gu, Y T

    2014-10-01

    Portable water-filled barriers (PWFBs) are roadside appurtenances that prevent vehicles from penetrating into temporary construction zones on roadways. PWFBs are required to satisfy the strict regulations for vehicle re-direction in tests. However, many of the current PWFBs fail to re-direct the vehicle at high speeds due to the inability of the joints to provide appropriate stiffness. The joint mechanism hence plays a crucial role in the performance of a PWFB system at high speed impacts. This paper investigates the desired features of the joint mechanism in a PWFB system that can re-direct vehicles at high speeds, while limiting the lateral displacement to acceptable limits. A rectangular "wall" representative of a 30m long barrier system was modeled and a novel method of joining adjacent road barriers was introduced through appropriate pin-joint connections. The impact response of the barrier "wall" and the vehicle was obtained and the results show that a rotational stiffness of 3000kNm/rad at the joints seems to provide the desired features of the PWFB system to re-direct impacting vehicles and restrict the lateral deflection. These research findings will be useful to safety engineers and road barrier designers in developing a new generation of PWFBs for increased road safety.

  5. Barriers to oral health across selected European countries and the USA.

    Science.gov (United States)

    Manski, Richard; Moeller, John

    2017-01-12

    In this review we consider oral-health access among older adults within and between the USA and various European countries with regard to possible primary financial and modifiable secondary non-financial factors. For older adults, the likelihood of using dental services has been associated, in the health literature, with a multiplicity of factors. These factors are traditionally classified into predisposing, enabling and need categories, and can be further classified into modifiable and non-modifiable subcategories. This raises the question of which single factor or group of factors has the most influence in keeping older adults from seeking care, and how these influences might differ between the USA and various other (European) countries. As it turns out, there is variation in the magnitude of effects across certain measurable potential barriers, but generally it takes a combination of characteristics associated with non-use to have a substantial impact.

  6. Modeling the Hydrogeochemical Transport of Radionuclides through Engineered Barriers System in the Proposed LLW Disposal Site of Taiwan - 12082

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Wen-Sheng [Hydrotech Research Institute, National Taiwan University, Taipei, Taiwan (China); Liu, Chen-Wuing; Tsao, Jui-Hsuan [Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan (China); Li, Ming-Hsu [Institute of Hydrological and Oceanic Sciences, National Central University, Jhongli, Taiwan (China)

    2012-07-01

    A proposed site for final disposal of low-level radioactive waste located in Daren Township of Taitung County along the southeastern coast has been on the selected list in Taiwan. The geology of the Daren site consists of argillite and meta-sedimentary rocks. A mined cavern design with a tunnel system of 500 m below the surface is proposed. Concrete is used as the main confinement material for the engineered barrier. To investigate the hydrogeochemical transport of radionuclides through engineered barriers system, HYDROGEOCHEM5.0 model was applied to simulate the complex chemical interactions among radionuclides, the cement minerals of the concrete, groundwater flow, and transport in the proposed site. The simulation results showed that the engineered barriers system with the side ditch efficiently drained the ground water and lowered the concentration of the concrete degradation induced species (e.g., hydrogen ion, sulfate, and chloride). The velocity of groundwater observed at side ditch gradually decreased with time due to the fouling of pore space by the mineral formation of ettringite and thaumasite. The short half-life of Co-60, Sr-90 and Cs-137 significantly reduced the concentrations, whereas the long half-life of I-129(1.57x10{sup 7} years) and Am-241(432 years) remain stable concentrations at the interface of waste canister and concrete barrier after 300 years. The mineral saturation index (SI) was much less than zero due to the low aqueous concentration of radionuclide, so that the precipitation formation of Co-60, Sr-90, I-129, Cs-137 and Am-241 related minerals were not found. The effect of adsorption/desorption (i.e., surface complexation model) could be a crucial geochemical mechanism for the modeling of liquid-solid phase behavior of radionuclide in geochemically dynamic environments. Moreover, the development of advanced numerical models that are coupled with hydrogeochemical transport and dose assessment of radionuclide is required in the future

  7. Socio-cultural barriers to the development of a sustainable energy system - the case of hydrogen

    DEFF Research Database (Denmark)

    Petersen, Lars Kjerulf; Andersen, Anne Holst

    Any transition to a more sustainable energy system, radically reducing greenhouse gas emissions, is bound to run in to a host of different barriers - technological and economic, but also socio-cultural. This will also be the case for any large-scale application of hydrogen as energy carrier......, especially if the system is going to be based on renewable energy sources. The aim of these research notes is to review and discuss major socio-cultural barriers to new forms of energy supply in general and to hydrogen specifically. Reaching sufficient reductions in greenhouse gas emissions may require more...

  8. A method of providing a barrier in a fracture-containing system

    DEFF Research Database (Denmark)

    2014-01-01

    The present invention relates to a method of providing a barrier in a fracture-containing system, comprising: i) Providing a treatment fluid comprising: a) a base fluid; b) an elastomeric material, wherein said elastomeric material comprises at least one polymer capable of crosslinking into an el......The present invention relates to a method of providing a barrier in a fracture-containing system, comprising: i) Providing a treatment fluid comprising: a) a base fluid; b) an elastomeric material, wherein said elastomeric material comprises at least one polymer capable of crosslinking...

  9. Solvent System Selection Strategies in Countercurrent Separation

    Science.gov (United States)

    Liu, Yang; Friesen, J. Brent; McAlpine, James B.; Pauli, Guido F.

    2015-01-01

    The majority of applications in countercurrent and centrifugal partition chromatography, collectively known as countercurrent separation, are dedicated to medicinal plant and natural product research. In countercurrent separation, the selection of the appropriate solvent system is of utmost importance as it is the equivalent to the simultaneous choice of column and eluent in liquid chromatography. However, solvent system selection is often laborious, involving extensive partition and/or analytical trials. Therefore, simplified solvent system selection strategies that predict the partition coefficients and, thus, analyte behavior are in high demand and may advance both the science of countercurrent separation and its applications. The last decade of solvent system selection theory and applications are critically reviewed, and strategies are classified according to their data input requirements. This offers the practitioner an up-to-date overview of rationales and methods for choosing an efficient solvent system, provides a perspective regarding their accuracy, reliability, and practicality, and discusses the possibility of combining multiple methods for enhanced prediction power. PMID:26393937

  10. Midgut barrier imparts selective resistance to filarial worm infection in Culex pipiens pipiens.

    Directory of Open Access Journals (Sweden)

    Michelle L Michalski

    Full Text Available Mosquitoes in the Culex pipiens complex thrive in temperate and tropical regions worldwide, and serve as efficient vectors of Bancroftian lymphatic filariasis (LF caused by Wuchereria bancrofti in Asia, Africa, the West Indies, South America, and Micronesia. However, members of this mosquito complex do not act as natural vectors for Brugian LF caused by Brugia malayi, or for the cat parasite B. pahangi, despite their presence in South Asia where these parasites are endemic. Previous work with the Iowa strain of Culex pipiens pipiens demonstrates that it is equally susceptible to W. bancrofti as is the natural Cx. p. pipiens vector in the Nile Delta, however it is refractory to infection with Brugia spp. Here we report that the infectivity barrier for Brugia spp. in Cx. p. pipiens is the mosquito midgut, which inflicts internal and lethal damage to ingested microfilariae. Following per os Brugia exposures, the prevalence of infection is significantly lower in Cx. p. pipiens compared to susceptible mosquito controls, and differs between parasite species with <50% and <5% of Cx. p. pipiens becoming infected with B. pahangi and B. malayi, respectively. When Brugia spp. mf were inoculated intrathoracically to bypass the midgut, larvae developed equally well as in controls, indicating that, beyond the midgut, Cx. p. pipiens is physiologically compatible with Brugia spp. Mf isolated from Cx. p. pipiens midguts exhibited compromised motility, and unlike mf derived from blood or isolated from the midguts of Ae. aegypti, failed to develop when inoculated intrathoracically into susceptible mosquitoes. Together these data strongly support the role of the midgut as the primary infection barrier for Brugia spp. in Cx. p. pipiens. Examination of parasites recovered from the Cx. p. pipiens midgut by vital staining, and those exsheathed with papain, suggest that the damage inflicted by the midgut is subcuticular and disrupts internal tissues. Microscopic studies

  11. Control Configuration Selection for Multivariable Nonlinear Systems

    DEFF Research Database (Denmark)

    Shaker, Hamid Reza; Komareji, Mohammad

    2012-01-01

    Control configuration selection is the procedure of choosing the appropriate input and output pairs for the design of SISO (or block) controllers. This step is an important prerequisite for a successful industrial control strategy. In industrial practices, it is often the case that systems, which...

  12. Jumping the nuclear envelop barrier: Improving polyplex-mediated gene transfection efficiency by a selective CDK1 inhibitor RO-3306.

    Science.gov (United States)

    Zhou, Xuefei; Liu, Xiangrui; Zhao, Bingxiang; Liu, Xin; Zhu, Dingcheng; Qiu, Nasha; Zhou, Quan; Piao, Ying; Zhou, Zhuxian; Tang, Jianbin; Shen, Youqing

    2016-07-28

    Successful transfection of plasmid DNA (pDNA) requires intranuclear internalization of pDNA effectively and the nuclear envelope appears to be one of the critical intracellular barriers for polymer mediated pDNA delivery. Polyethylenimine (PEI), as the classic cationic polymer, compact the negatively charged pDNA tightly and make up stable polyplexes. The polyplexes are too large to enter the nuclear through nuclear pores and it is believed that the nuclear envelope breakdown in mitosis could facilitate the nuclear entry of polyplexes. To jump the nuclear envelope barrier, we used a selective and reversible CDK1 inhibitor RO-3306 to control the G2/M transition of the cell cycle and increased the proportion of mitotic cells which have disappeared nuclear envelope during transfection. Herein, we show that RO-3306 remarkably increases the transfection efficiency of PEI polyplexes through enhanced nuclear localization of PEI and pDNA. However, RO-3306 is less effective to the charge-reversal polymer poly[(2-acryloyl)ethyl(p-boronic acid benzyl)diethylammonium bromide] (B-PDEAEA) which responses to cellular stimuli and releases free pDNA in cytoplasm. Our findings not only offer new opportunities for improving non-viral based gene delivery but also provide theoretical support for the rational design of novel functional polymers for gene delivery. We also report current data showing that RO-3306 synergizes TRAIL gene induced apoptosis in cancer cells.

  13. Progress of the AVNG System - Attribute Verification System with Information Barriers for Mass Isotopics Measurements.

    Energy Technology Data Exchange (ETDEWEB)

    Budnikov, D. (Dmitry); Bulatov, M. (Mikhail); Jarikhine, I. (Igor); Lebedev, B. (Boris); Livke, A. (Alexander); Modenov, A.; Morkin, A. (Anton); Razinkov, S. (Sergei); Tsaregorodtsev, D. (Dmitry); Vlokh, A. (Andrey); Yakovleva, S. (Svetlana); Elmont, T. H. (Timothy H.); Langner, D. C. (Diana C.); MacArthur, D. W. (Duncan W.); Mayo, D. R. (Douglas R.); Smith, M. K. (Morag K.); Luke, S. J. (S. John)

    2005-01-01

    An attribute verification system (AVNG) with information barriers for mass and isotopics measurements has been designed and its fabrication is nearly completed. The AVNG is being built by scientists at the Russian Federal Nuclear Center-VNIIEF, with support of Los Alamos National Laboratory (LANL) and Lawrence Livermore National Laboratory (LLNL). Such a system could be used to verify the presence of several unclassified attributes of classified material with no classified information release. The system is comprised of a neutron multiplicity counter and gamma-spectrometry system based on a high purity germanium gamma detector (nominal relative efficiency @ 1332 keV 50%) and digital gamma-ray spectrometer DSPEC{sup PLUS}. The neutron multiplicity counter is a three ring counter with 164 {sup 3}He tubes. The system was designed to measure prototype containers 491 mm in diameter and 503 mm high. This paper provides a brief history of the project and documents the progress of this effort with drawings and photographs.

  14. PROGRESS OF THE AVNG SYSTEM - ATTRIBUTE VERIFICATION SYSTEM WITH INFORMATION BARRIERS FOR MASS AND ISOTOPICS MEASUREMENTS

    Energy Technology Data Exchange (ETDEWEB)

    Budnikov, D; Bulatov, M; Jarikhine, I; Lebedev, B; Livke, A; Modenov, A; Morkin, A; Razinkov, S; Safronov, S; Tsaregorodtsev, D; Vlokh, A; Yakovleva, S; Elmont, T; Langner, D; MacArthur, D; Mayo, D; Smith, M; Luke, S J

    2005-05-27

    An attribute verification system (AVNG) with information barriers for mass and isotopics measurements has been designed and its fabrication is nearly completed. The AVNG is being built by scientists at the Russian Federal Nuclear Center-VNIIEF, with support of Los Alamos National Laboratory (LANL) and Lawrence Livermore National Laboratory (LLNL). Such a system could be used to verify the presence of several unclassified attributes of classified material with no classified information release. The system is comprised of a neutron multiplicity counter and gamma-spectrometry system based on a high purity germanium gamma detector (nominal relative efficiency {at} 1332 keV 50%) and digital gamma-ray spectrometer DSPEC{sup PLUS}. The neutron multiplicity counter is a three ring counter with 164 {sup 3}He tubes. The system was designed to measure prototype containers 491 mm in diameter and 503 mm high. This paper provides a brief history of the project and documents the progress of this effort with drawings and photographs.

  15. Model for personal computer system selection.

    Science.gov (United States)

    Blide, L

    1987-12-01

    Successful computer software and hardware selection is best accomplished by following an organized approach such as the one described in this article. The first step is to decide what you want to be able to do with the computer. Secondly, select software that is user friendly, well documented, bug free, and that does what you want done. Next, you select the computer, printer and other needed equipment from the group of machines on which the software will run. Key factors here are reliability and compatibility with other microcomputers in your facility. Lastly, you select a reliable vendor who will provide good, dependable service in a reasonable time. The ability to correctly select computer software and hardware is a key skill needed by medical record professionals today and in the future. Professionals can make quality computer decisions by selecting software and systems that are compatible with other computers in their facility, allow for future net-working, ease of use, and adaptability for expansion as new applications are identified. The key to success is to not only provide for your present needs, but to be prepared for future rapid expansion and change in your computer usage as technology and your skills grow.

  16. Advanced thermal barrier system bond coatings for use on Ni, Co-, and Fe-base alloy substrates

    Science.gov (United States)

    Stecura, S.

    1985-01-01

    New and improved Ni-, Co-, and Fe-base bond coatings have been identified for the ZrO2-Y2O3 thermal barrier coatings to be used on NI-, Co-, and Fe-base alloy substrates. These bond coatings were evaluated in a cyclic furnace between 1120 and 1175 C. It was found that MCrAlYb (where M = Ni, Co, or Fe) bond coating thermal barrier systems. The longest life was obtained with the FeCrAlYb thermal barrier system followed by NiCrAlYb and CoCrAlYb thermal barrier systems in that order.

  17. Cell-Penetrating Peptides Selectively Cross the Blood-Brain Barrier In Vivo.

    Directory of Open Access Journals (Sweden)

    Sofie Stalmans

    Full Text Available Cell-penetrating peptides (CPPs are a group of peptides, which have the ability to cross cell membrane bilayers. CPPs themselves can exert biological activity and can be formed endogenously. Fragmentary studies demonstrate their ability to enhance transport of different cargoes across the blood-brain barrier (BBB. However, comparative, quantitative data on the BBB permeability of different CPPs are currently lacking. Therefore, the in vivo BBB transport characteristics of five chemically diverse CPPs, i.e. pVEC, SynB3, Tat 47-57, transportan 10 (TP10 and TP10-2, were determined. The results of the multiple time regression (MTR analysis revealed that CPPs show divergent BBB influx properties: Tat 47-57, SynB3, and especially pVEC showed very high unidirectional influx rates of 4.73 μl/(g × min, 5.63 μl/(g × min and 6.02 μl/(g × min, respectively, while the transportan analogs showed a negligible to low brain influx. Using capillary depletion, it was found that 80% of the influxed peptides effectively reached the brain parenchyma. Except for pVEC, all peptides showed a significant efflux out of the brain. Co-injection of pVEC with radioiodinated bovine serum albumin (BSA did not enhance the brain influx of radiodionated BSA, indicating that pVEC does not itself significantly alter the BBB properties. A saturable mechanism could not be demonstrated by co-injecting an excess dose of non-radiolabeled CPP. No significant regional differences in brain influx were observed, with the exception for pVEC, for which the regional variations were only marginal. The observed BBB influx transport properties cannot be correlated with their cell-penetrating ability, and therefore, good CPP properties do not imply efficient brain influx.

  18. An Activity Theory Approach to Analyze Barriers to a Virtual Management Information Systems (MIS) Curriculum

    Science.gov (United States)

    Jaradat, Suhair; Qablan, Ahmad; Barham, Areej

    2011-01-01

    This paper explains how the activity theory is used as a framework to analyze the barriers to a virtual Management Information Stream (MIS) Curriculum in Jordanian schools, from both the sociocultural and pedagogical perspectives. Taking the activity system as a unit of analysis, this study documents the processes by which activities shape and are…

  19. The immune system mediates blood-brain barrier damage; Possible implications for pathophysiology of neuropsychiatric illnesses

    NARCIS (Netherlands)

    VanderWerf, YD; DeJongste, MJL; terHorst, GJ

    1995-01-01

    The immune system mediates blood-brain barrier damage; possible implications for pathophysiology of neuropsychiatric illnesses. In this investigation the effects of immune activation on the brain are characterized In order to study this, we used a model for chronic immune activation, the myocardial

  20. Underutilization of Mental Health Services among College Students: An Examination of System-Related Barriers

    Science.gov (United States)

    Marsh, Carey N.; Wilcoxon, S. Allen

    2015-01-01

    Despite the documented benefits of counseling and mental health services on academic performance and degree attainment, only about 10% of psychologically distressed college students ever seek professional help. This investigation examined mental health care system-related barriers that might distinguish help seekers from nonhelp seekers among…

  1. Selecting RMF Controls for National Security Systems

    Energy Technology Data Exchange (ETDEWEB)

    Witzke, Edward L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-08-01

    In 2014, the United States Department of Defense started tra nsitioning the way it performs risk management and accreditation of informatio n systems to a process entitled Risk Management Framework for DoD Information Technology or RMF for DoD IT. There are many more security and privacy contro ls (and control enhancements) from which to select in RMF, than there w ere in the previous Information Assurance process. This report is an attempt t o clarify the way security controls and enhancements are selected. After a brief overview and comparison of RMF for DoD I T with the previously used process, this report looks at the determination of systems as National Security Systems (NSS). Once deemed to be an NSS, this report addr esses the categorization of the information system with respect to impact level s of the various security objectives and the selection of an initial baseline o f controls. Next, the report describes tailoring the controls through the use of overl ays and scoping considerations. Finally, the report discusses organizatio n-defined values for tuning the security controls to the needs of the information system.

  2. Energy System selection for Small Underwater Vehicles

    Institute of Scientific and Technical Information of China (English)

    G.T.Reader; J.G.Hawley; 等

    1994-01-01

    The oceans cover almost three-quarters of the earth's surface and provide a highway for commerce or conquest and constitute a rich source of nutrients.materials and emergy.The exploration and exploitation of oceanic resources accelerated in the 1970s because of the merging offshore oil and gas industry.The extraction and national protection of these and other resources will increase rapidly in the next century and in support of these activities one of the most useful tools will be the small underwater vehicle.However,if these vehicles are to carry out the envisageed tasks in a cost-effective and mission-effective manner they will require high performance energy systems.A number of such systems are being developed and the problem arises as which one to select for a particular task.In this paper the development of software based techniques for the selection of energy systems is described.

  3. Thermal and Environmental Barrier Coating Development for Advanced Propulsion Engine Systems

    Science.gov (United States)

    Zhu, Dongming; Miller, Robert A.; Fox, Dennis S.

    2008-01-01

    Ceramic thermal and environmental barrier coatings (TEBCs) are used in gas turbine engines to protect engine hot-section components in the harsh combustion environments, and extend component lifetimes. Advanced TEBCs that have significantly lower thermal conductivity, better thermal stability and higher toughness than current coatings will be beneficial for future low emission and high performance propulsion engine systems. In this paper, ceramic coating design and testing considerations will be described for turbine engine high temperature and high-heat-flux applications. Thermal barrier coatings for metallic turbine airfoils and thermal/environmental barrier coatings for SiC/SiC ceramic matrix composite (CMC) components for future supersonic aircraft propulsion engines will be emphasized. Further coating capability and durability improvements for the engine hot-section component applications can be expected by utilizing advanced modeling and design tools.

  4. Aircraft engine-mounted camera system for long wavelength infrared imaging of in-service thermal barrier coated turbine blades

    Science.gov (United States)

    Markham, James; Cosgrove, Joseph; Scire, James; Haldeman, Charles; Agoos, Ian

    2014-12-01

    This paper announces the implementation of a long wavelength infrared camera to obtain high-speed thermal images of an aircraft engine's in-service thermal barrier coated turbine blades. Long wavelength thermal images were captured of first-stage blades. The achieved temporal and spatial resolutions allowed for the identification of cooling-hole locations. The software and synchronization components of the system allowed for the selection of any blade on the turbine wheel, with tuning capability to image from leading edge to trailing edge. Its first application delivered calibrated thermal images as a function of turbine rotational speed at both steady state conditions and during engine transients. In advance of presenting these data for the purpose of understanding engine operation, this paper focuses on the components of the system, verification of high-speed synchronized operation, and the integration of the system with the commercial jet engine test bed.

  5. Application of CFRP with High Hydrogen Gas Barrier Characteristics to Fuel Tanks of Space Transportation System

    Science.gov (United States)

    Yonemoto, Koichi; Yamamoto, Yuta; Okuyama, Keiichi; Ebina, Takeo

    In the future, carbon fiber reinforced plastics (CFRPs) with high hydrogen gas barrier performance will find wide applications in all industrial hydrogen tanks that aim at weight reduction; the use of such materials will be preferred to the use of conventional metallic materials such as stainless steel or aluminum. The hydrogen gas barrier performance of CFRP will become an important issue with the introduction of hydrogen-fuel aircraft. It will also play an important role in realizing fully reusable space transportation system that will have high specific tensile CFRP structures. Such materials are also required for the manufacture of high-pressure hydrogen gas vessels for use in the fuel cell systems of automobiles. This paper introduces a new composite concept that can be used to realize CFRPs with high hydrogen gas barrier performance for applications in the cryogenic tanks of fully reusable space transportation system by the incorporation of a nonmetallic crystal layer, which is actually a dense and highly oriented clay crystal laminate. The preliminary test results show that the hydrogen gas barrier characteristics of this material after cryogenic heat shocks and cyclic loads are still better than those of other polymer materials by approximately two orders of magnitude.

  6. Drug Delivery Systems, CNS Protection, and the Blood Brain Barrier

    Directory of Open Access Journals (Sweden)

    Ravi Kant Upadhyay

    2014-01-01

    Full Text Available Present review highlights various drug delivery systems used for delivery of pharmaceutical agents mainly antibiotics, antineoplastic agents, neuropeptides, and other therapeutic substances through the endothelial capillaries (BBB for CNS therapeutics. In addition, the use of ultrasound in delivery of therapeutic agents/biomolecules such as proline rich peptides, prodrugs, radiopharmaceuticals, proteins, immunoglobulins, and chimeric peptides to the target sites in deep tissue locations inside tumor sites of brain has been explained. In addition, therapeutic applications of various types of nanoparticles such as chitosan based nanomers, dendrimers, carbon nanotubes, niosomes, beta cyclodextrin carriers, cholesterol mediated cationic solid lipid nanoparticles, colloidal drug carriers, liposomes, and micelles have been discussed with their recent advancements. Emphasis has been given on the need of physiological and therapeutic optimization of existing drug delivery methods and their carriers to deliver therapeutic amount of drug into the brain for treatment of various neurological diseases and disorders. Further, strong recommendations are being made to develop nanosized drug carriers/vehicles and noninvasive therapeutic alternatives of conventional methods for better therapeutics of CNS related diseases. Hence, there is an urgent need to design nontoxic biocompatible drugs and develop noninvasive delivery methods to check posttreatment clinical fatalities in neuropatients which occur due to existing highly toxic invasive drugs and treatment methods.

  7. Frictional energy barrier and blocking temperature in water molecules and carbon nanotubes system

    Science.gov (United States)

    Zhang, Jianwei; Li, Jiaxi; Li, Wenfeng

    2015-03-01

    Water transport through hydrophobic channels of single-walled carbon nanotubes has attracted a lot interests, especially, various potential applications of SWCNTs have been proposed for designing novel nanofluidic devices. By adopting Molecular dynamics method, we investigated mechanics and statistics properties of water molecules escaping from a confined single-walled carbon nanotube. From our numerical MD simulations and statistical model, we determined the friction energy barrier of water molecules in (10.10) SWCNT is 9.88 kcal/mol, and which is the minimal energy for flowing a water molecules in CNT. By only using friction energy barrier and relaxation time parameter, our model can fit all different situations MD simulation results. In order to describing the frictional lock behavior of water molecules, we introduced a new blocking temperature, below this temperature (391K for our system), water is locked in CNT due to friction energy barrier. We found that the blocking temperature is closely related to system response time, and it also shows a linear behavior to frictional energy barrier. Furthermore, we found several other interesting statistics results when a water molecules leaving SWCNTs. This work was supported by NSFC No. 11274240 and NO. 51471119.

  8. Barrier Lyapunov function-based model-free constraint position control for mechanical systems

    Energy Technology Data Exchange (ETDEWEB)

    Han, Seong Ik; Ha, Hyun Uk; Lee, Jang Myung [Pusan National University, Busan (Korea, Republic of)

    2016-07-15

    In this article, a motion constraint control scheme is presented for mechanical systems without a modeling process by introducing a barrier Lyapunov function technique and adaptive estimation laws. The transformed error and filtered error surfaces are defined to constrain the motion tracking error in the prescribed boundary layers. Unknown parameters of mechanical systems are estimated using adaptive laws derived from the Lyapunov function. Then, robust control used the conventional sliding mode control, which give rise to excessive chattering, is changed to finite time-based control to alleviate undesirable chattering in the control action and to ensure finite-time error convergence. Finally, the constraint controller from the barrier Lyapunov function is designed and applied to the constraint of the position tracking error of the mechanical system. Two experimental examples for the XY table and articulated manipulator are shown to evaluate the proposed control scheme.

  9. The Barriers in Writing With Students:Topic Selection and Organizing Ideas

    Institute of Scientific and Technical Information of China (English)

    加米拉

    2014-01-01

    Students with having difficulties in writing can improve their written expression through choosing topic, planning and organizing ideas. Teaching topic selection through promoting students’ confidence in writing, providing an opportunity to discover what they know, and presenting a story. With proper instruction, students who need extra help in writing can become excellent writers. And it’s also important to be able to read what the students with unique needs have written.%教师可以通过选择适宜的题目来帮助在学习写作上有困难的学生。教师也要充分认识到有着独特需求的学生所写的东西。本文就在课堂写作教学中如何在课堂教学中提高学生的写作能力,使用何种方法来帮助学生写出优秀的文章来,做点浅论。

  10. Trapping gases in metal-organic frameworks with a selective surface molecular barrier layer

    Science.gov (United States)

    Tan, Kui; Zuluaga, Sebastian; Fuentes, Erika; Mattson, Eric C.; Veyan, Jean-François; Wang, Hao; Li, Jing; Thonhauser, Timo; Chabal, Yves J.

    2016-12-01

    The main challenge for gas storage and separation in nanoporous materials is that many molecules of interest adsorb too weakly to be effectively retained. Instead of synthetically modifying the internal surface structure of the entire bulk--as is typically done to enhance adsorption--here we show that post exposure of a prototypical porous metal-organic framework to ethylenediamine can effectively retain a variety of weakly adsorbing molecules (for example, CO, CO2, SO2, C2H4, NO) inside the materials by forming a monolayer-thick cap at the external surface of microcrystals. Furthermore, this capping mechanism, based on hydrogen bonding as explained by ab initio modelling, opens the door for potential selectivity. For example, water molecules are shown to disrupt the hydrogen-bonded amine network and diffuse through the cap without hindrance and fully displace/release the retained small molecules out of the metal-organic framework at room temperature. These findings may provide alternative strategies for gas storage, delivery and separation.

  11. Advanced thermal barrier system bond coatings for use on nickel-, cobalt- and iron-base alloy substrates

    Science.gov (United States)

    Stecura, S.

    1986-01-01

    New and improved Ni-, Co-, and Fe-base bond coatings have been identified for the ZrO2-Y2O3 thermal barrier coatings to be used on Ni-, Co-, and Fe-base alloy substrates. These bond coatings were evaluated in a cyclic furnace between 1120 and 1175 C. It was found that MCrAlYb (where M = Ni, Co, or Fe) bond coating thermal barrier systems have significantly longer lives than MCrAlY bond coating thermal barrier systems. The longest life was obtained with the FeCrAlYb thermal barrier system followed by NiCrAlYb and CoCrAlYb thermal barrier systems in that order.

  12. Reducing Barriers To The Use of High-Efficiency Lighting Systems

    Energy Technology Data Exchange (ETDEWEB)

    Peter Morante

    2005-12-31

    With funding from the U.S. Department of Energy (DOE), the Lighting Research Center (LRC) at Rensselaer Polytechnic Institute completed the four-year research project, Reducing Barriers to the Use of High-Efficiency Lighting Systems. The initial objectives were: (1) identifying barriers to widespread penetration of lighting controls in commercial/industrial (C/I) applications that employ fluorescent lamp technologies, and (2) making recommendations to overcome these barriers. The addition of a fourth year expanded the original project objectives to include an examination of the impact on fluorescent lamps from dimming utilizing different lamp electrode heating and dimming ratios. The scope of the project was narrowed to identify barriers to the penetration of lighting controls into commercial-industrial (C/I) applications that employ fluorescent lamp technologies, and to recommend means for overcoming these barriers. Working with lighting manufacturers, specifiers, and installers, the project identified technological and marketing barriers to the widespread use of lighting controls, specifically automatic-off controls, occupancy sensors, photosensors, dimming systems, communication protocols and load-shedding ballasts. The primary barriers identified include cost effectiveness of lighting controls to the building owner, lack of standard communication protocols to allow different part of the control system to communicate effectively, and installation and commissioning issues. Overcoming the identified barriers requires lighting control products on the market to achieve three main goals: (1) Achieve sufficient functionality to meet the key requirements of their main market. (2) Allow significant cost reduction compared to current market standard systems. Cost should consider: hardware capital cost including wiring, design time required by the specifier and the control system manufacturer, installation time required by the electrician, and commissioning time and

  13. Barriers in the Implementation of Health Information Systems: A Scoping Review

    Directory of Open Access Journals (Sweden)

    Florin STAMATIAN

    2013-12-01

    Full Text Available Context. A well-developed health information system which is implemented according to present standards allows a healthcare quality increase. Our study aims at providing an overview of the barriers which were encountered in the process of implementing the health information systems by reviewing the literature connected to Europe and the United States of America. Methodology. We searched within five databases (Cochrane Library, Google Scholar, PubMed, ScienceDirect and Scopus for the exact phrase ‘implementation health information system’ along with the name of each European country/USA state. Relevance was then tested by scanning titles and abstracts. The third and final step involved assessing all the articles in order to set their relevance and a data extraction tool was created, containing the name of the state/country that the article reports data on, the article citation and the challenges identified. Results. The barriers identified were classified in four major categories: technical, organizational, behavioral/human and financial. Seemingly, Europe (41 articles and USA (20 articles are facing the same issues in the implementation of a health information system. No major difference between EU and non-EU countries was found after our analysis with regards to the identified barriers. Discussion. Even if recommendations and solutions are continuously being developed in order to solve these barriers, the implementation of a new health information system must be very detailed in order to face all these problems. Additionally, further research is required in order to evaluate their impact on the successful implementation of a health information system.

  14. Vegetation barrier and tillage effects on runoff and sediment in an alley crop system on a Luvisol in Burkina Faso

    NARCIS (Netherlands)

    Spaan, W.P.; Sikking, A.F.S.; Hoogmoed, W.B.

    2005-01-01

    The effects of vegetation barriers and tillage on runoff and soil loss were evaluated in an alley crop system at a research station in central Burkina Faso. On a 2% slope of a sandy loam various local species (grasses, woody species and a succulent) were planted as conservation barriers in order to

  15. The mechanisms of neurotoxicity and the selective vulnerability of nervous system sites.

    Science.gov (United States)

    Maurer, Laura L; Philbert, Martin A

    2015-01-01

    The spatial heterogeneity of the structure, function, and cellular composition of the nervous system confers extraordinary complexity and a multiplicity of mechanisms of chemical neurotoxicity. Because of its relatively high metabolic demands and functional dependence on postmitotic neurons, the nervous system is vulnerable to a variety of xenobiotics that affect essential homeostatic mechanisms that support function. Despite protection from the neuroglia and blood-brain barrier, the central nervous system is prone to attack from lipophilic toxicants and those that hijack endogenous transport, receptor, metabolic, and other biochemical systems. The inherent predilection of chemicals for highly conserved biochemical systems confers selective vulnerability of the nervous system to neurotoxicants. This chapter discusses selective vulnerability of the nervous system in the context of neuron-specific decrements (axonopathy, myelinopathy, disruption of neurotransmission), and the degree to which neuronal damage is facilitated or ameliorated by surrounding nonneural cells in both the central and peripheral nervous systems.

  16. An Immunized Aircraft Maneuver Selection System

    Science.gov (United States)

    Karr, Charles L.

    2003-01-01

    The objective of this project, as stated in the original proposal, was to develop an immunized aircraft maneuver selection (IAMS) system. The IAMS system was to be composed of computational and informational building blocks that resemble structures in natural immune systems. The ultimate goal of the project was to develop a software package that could be flight tested on aircraft models. This report describes the work performed in the first year of what was to have been a two year project. This report also describes efforts that would have been made in the final year to have completed the project, had it been continued for the final year. After introductory material is provided in Section 2, the end-of-year-one status of the effort is discussed in Section 3. The remainder of the report provides an accounting of first year efforts. Section 4 provides background information on natural immune systems while Section 5 describes a generic ar&itecture developed for use in the IAMS. Section 6 describes the application of the architecture to a system identification problem. Finally, Section 7 describes steps necessary for completing the project.

  17. Supplier Selection Using Fuzzy Inference System

    Directory of Open Access Journals (Sweden)

    hamidreza kadhodazadeh

    2014-01-01

    Full Text Available Suppliers are one of the most vital parts of supply chain whose operation has significant indirect effect on customer satisfaction. Since customer's expectations from organization are different, organizations should consider different standards, respectively. There are many researches in this field using different standards and methods in recent years. The purpose of this study is to propose an approach for choosing a supplier in a food manufacturing company considering cost, quality, service, type of relationship and structure standards of the supplier organization. To evaluate supplier according to the above standards, the fuzzy inference system has been used. Input data of this system includes supplier's score in any standard that is achieved by AHP approach and the output is final score of each supplier. Finally, a supplier has been selected that although is not the best in price and quality, has achieved good score in all of the standards.

  18. The intestinal barrier in irritable bowel syndrome: subtype-specific effects of the systemic compartment in an in vitro model.

    Directory of Open Access Journals (Sweden)

    Samefko Ludidi

    Full Text Available Irritable bowel syndrome (IBS is a disorder with multifactorial pathophysiology. Intestinal barrier may be altered, especially in diarrhea-predominant IBS (IBS-D. Several mediators may contribute to increased intestinal permeability in IBS.We aimed to assess effects of tryptase and LPS on in vitro permeability using a 3-dimensional cell model after basolateral cell exposure. Furthermore, we assessed the extent to which these mediators in IBS plasma play a role in intestinal barrier function.Caco-2 cells were grown in extracellular matrix to develop into polarized spheroids and were exposed to tryptase (10 - 50 mU, LPS (1 - 50 ng/mL and two-fold diluted plasma samples of 7 patients with IBS-D, 7 with constipation-predominant IBS (IBS-C and 7 healthy controls (HC. Barrier function was assessed by the flux of FITC-dextran (FD4 using live cell imaging. Furthermore, plasma tryptase and LPS were determined.Tryptase (20 and 50 mU and LPS (6.25 - 50 ng/mL significantly increased Caco-2 permeability versus control (all P< 0.05. Plasma of IBS-D only showed significantly elevated median tryptase concentrations (7.1 [3.9 - 11.0] vs. 4.2 [2.2 - 7.0] vs. 4.2 [2.5 - 5.9] μg/mL; P<0.05 and LPS concentrations (3.65 [3.00 - 6.10] vs. 3.10 [2.60-3.80] vs. 2.65 [2.40 - 3.40] EU/ml; P< 0.05 vs. IBS-C and HC. Also, plasma of IBS-D increased Caco-2 permeability versus HC (0.14450 ± 0.00472 vs. 0.00021 ± 0.00003; P < 0.001, which was attenuated by selective inhibition of tryptase and LPS (P< 0.05.Basolateral exposure of spheroids to plasma of IBS-D patients resulted in a significantly increased FD4 permeation, which was partially abolished by selective inhibition of tryptase and LPS. These findings point to a role of systemic tryptase and LPS in the epithelial barrier alterations observed in patients with IBS-D.

  19. Nanoparticles and blood-brain barrier: the key to central nervous system diseases.

    Science.gov (United States)

    Domínguez, Alazne; Suárez-Merino, Blanca; Goñi-de-Cerio, Felipe

    2014-01-01

    Major central nervous system disorders represent a significant and worldwide public health problem. In fact, the therapeutic success of many pharmaceuticals developed to treat central nervous system diseases is still moderate, since the blood-brain barrier (BBB) limits the access of systemically administered compounds to the brain. Therefore, they require the application of a large total dose of a drug, and cause numerous toxic effects. The development of nanotechnological systems are useful tools to deliver therapeutics and/or diagnostic probes to the brain due to nanocarriers having the potential to improve the therapeutic effect of drugs and to reduce their side effects. This review provides a brief overview of the variety of carriers employed for central nervous system drug and diagnostic probes delivery. Further, this paper focuses on the novel nanocarriers developed to enhance brain delivery across the blood-brain barrier. Special attention is paid to liposomes, micelles, polymeric and lipid-based nanoparticles, dendrimers and carbon nanotubes. The recent developments in nanocarrier implementation through size/charge optimization and surface modifications (PEGylation, targeting delivery, and coating with surfactants) have been discussed. And a detailed description of the nanoscaled pharmaceutical delivery devices employed for the treatment of central nervous system disorders have also been defined. The aim of the review is to evaluate the nanotechnology-based drug delivery strategies to treat different central nervous system disorders.

  20. Influences of specific ions in groundwater on concrete degradation in subsurface engineered barrier system.

    Science.gov (United States)

    Lin, Wen-Sheng; Liu, Chen-Wuing; Li, Ming-Hsu

    2016-01-01

    Many disposal concepts currently show that concrete is an effective confinement material used in engineered barrier systems (EBS) at a number of low-level radioactive waste (LLW) disposal sites. Cement-based materials have properties for the encapsulation, isolation, or retardation of a variety of hazardous contaminants. The reactive chemical transport model of HYDROGEOCHEM 5.0 was applied to simulate the effect of hydrogeochemical processes on concrete barrier degradation in an EBS which has been proposed to use in the LLW disposal site in Taiwan. The simulated results indicated that the main processes that are responsible for concrete degradation are the species induced from hydrogen ion, sulfate, and chloride. The EBS with the side ditch drainage system effectively discharges the infiltrated water and lowers the solute concentrations that may induce concrete degradation. The redox processes markedly influence the formations of the degradation materials. The reductive environment in the EBS reduces the formation of ettringite in concrete degradation processes. Moreover, the chemical conditions in the concrete barriers maintain an alkaline condition after 300 years in the proposed LLW repository. This study provides a detailed picture of the long-term evolution of the hydrogeochemical environment in the proposed LLW disposal site in Taiwan.

  1. Breakup mechanisms for 7Li + 197Au, 204Pb systems at sub-barrier energies

    Directory of Open Access Journals (Sweden)

    Luong D.H.

    2013-12-01

    Full Text Available Coincidence measurements of breakup fragments were carried out for the 7Li + 197Au and 204Pb systems at sub-barrier energies. The mechanisms triggering breakup, and time-scales of each process, were identified through the reaction Q-values and the relative energy of the breakup fragments. Binary breakup of 7Li were found to be predominantly triggered by nucleon transfer, with p-pickup leading to 8Be → α + α decay being the preferred breakup mode. From the time-scales of each process, the coincidence yields were separated into prompt and delayed components, allowing the identification of breakup process important in the suppression of complete fusion of 7Li at above-barrier energies.

  2. Effects of sea-level rise on barrier island groundwater system dynamics: ecohydrological implications

    Science.gov (United States)

    Masterson, John P.; Fienen, Michael N.; Thieler, E. Robert; Gesch, Dean B.; Gutierrez, Benjamin T.; Plant, Nathaniel G.

    2014-01-01

    We used a numerical model to investigate how a barrier island groundwater system responds to increases of up to 60 cm in sea level. We found that a sea-level rise of 20 cm leads to substantial changes in the depth of the water table and the extent and depth of saltwater intrusion, which are key determinants in the establishment, distribution and succession of vegetation assemblages and habitat suitability in barrier islands ecosystems. In our simulations, increases in water-table height in areas with a shallow depth to water (or thin vadose zone) resulted in extensive groundwater inundation of land surface and a thinning of the underlying freshwater lens. We demonstrated the interdependence of the groundwater response to island morphology by evaluating changes at three sites. This interdependence can have a profound effect on ecosystem composition in these fragile coastal landscapes under long-term changing climatic conditions.

  3. Symmetric splitting for the system 32S+238U at energies near and below the barrier

    Science.gov (United States)

    Freifelder, R.; Braun-Munzinger, P.; Deyoung, P.; Schicker, R.; Sen, S.; Stachel, J.

    1987-06-01

    The total capture cross section for the system 32S+238U has been measured at energies from 0.93 to 1.08 times the s-wave interaction barrier by detecting coincident fission fragments following full momentum transfer reactions. The subbarrier cross section cannot be reproduced by a one-dimensional barrier penetration model. Using a quantum mechanical coupled channels model, good agreement is obtained. The measured angular distributions of fission fragments were compared to the predictions of saddle and scission point transition state theory. Saddle point transition state model calculations fail to reproduce the data, while scission point transition state calculations are in agreement with their qualitative trend. Evidence for nonequilibrium processes is presented.

  4. Marsh Edge Erosion Effects in Coupled Barrier Island-Marsh Systems

    Science.gov (United States)

    Lauzon, R.; Moore, L. J.; Murray, A. B.; Walters, D.; Fagherazzi, S.; Mariotti, G.

    2014-12-01

    While until recently marsh loss was largely thought to be due to an inability for vertical accretion rates to match rates of sea level rise, marsh edge erosion by wind waves is now thought to be the leading cause of marsh loss worldwide. To better understand the response of coastal ecosystems to future changes in sea level and storm intensity, we further develop the coupled barrier-island marsh evolution model GEOMBEST+. We use the relationship between wave height (and therefore energy) and fetch and wind speed to add marsh edge erosion to the model, as well as to provide a more physical formulation for bay bottom erosion. Previous research addressing marshes in isolation from barrier islands (Mariotti and Fagherazzi, 2013) suggests that the existence of a backbarrier marsh is an unstable state, tending to either grow laterally to completely fill an adjacent basin or to erode away completely. Previous results of GEOMBEST+ experiments (Walters et al., in review) suggest that couplings with an adjacent barrier island can add an additional alternate long-lasting state: a narrow marsh supported by sediment influx from overwash. Here we present the results of new GEOMBEST+ model experiments that address how the addition of lateral erosion by wind waves affects the existence and characteristics of the narrow marsh state. Specifically, we seek to address how the frequency and characteristic time and space scales of the narrow march state are affected. Model experiments also explore more broadly the importance of wind wave effects in understanding the coupled dynamics of marsh-barrier island systems.

  5. Asphalt emulsion radon barrier systems for uranium mill tailings: an overview of the technology

    Energy Technology Data Exchange (ETDEWEB)

    Baker, E.G.; Hartley, J.N.; Freeman, H.D.; Gates, T.E.; Nelson, D.A.; Dunning, R.L.

    1984-03-01

    Pacific Northwest Laboratory (PNL), under contract to the US Department of Energy (DOE) Uranium Mill Tailings Remedial Action Project (UMTRAP) office, has developed an asphalt emulsion cover system to reduce the release of radon from uranium mill tailings. The system has been field tested at Grand Junction, Colorado. Results from laboratory and field tests indicate that this system is effective in reducing radon release to near-background levels (<2.5 pCi m/sup -2/s/sup -1/) and has the properties required for long-term effectiveness and stability. Engineering specifications have been developed, and analysis indicates that asphalt emulsion covers are cost-competitive with other cover systems. This report summarizes the technology for asphalt emulsion radon barrier systems. 59 references, 45 figures, 36 tables.

  6. Fission Meter Information Barrier Attribute Measurement System: Task 1 Report: Document existing Fission Meter neutron IB system

    Energy Technology Data Exchange (ETDEWEB)

    Kerr, P. L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-02-28

    An SNM attribute Information Barrier (IB) system was developed for a 2011 US/UK Exercise. The system was modified and extensively tested in a 2013-2014 US-UK Measurement Campaign. This work demonstrated rapid deployment of an IB system for potential treaty use. The system utilizes an Ortec Fission Meter neutron multiplicity counter and custom computer code. The system demonstrates a proof-of-principle automated Pu-240 mass determination with an information barrier. After a software start command is issued, the system automatically acquires and downloads data, performs an analysis, and displays the results. This system conveys the results of a Pu mass threshold measurements in a way the does not reveal sensitive information. In full IB mode, only red/green ‘lights’ are displayed in the software. In test mode, more detailed information is displayed. The code can also read in, analyze, and display results from previously acquired or simulated data. Because the equipment is commercial-off-the-shelf (COTS), the system demonstrates a low-cost short-lead-time technology for treaty SNM attribute measurements. A deployed system will likely require integration of additional authentication and tamper-indicating technologies. This will be discussed for the project in this and future progress reports.

  7. Evolution of fusion hindrance for asymmetric systems at deep sub-barrier energies

    Directory of Open Access Journals (Sweden)

    A. Shrivastava

    2016-04-01

    Full Text Available Measurements of fusion cross-sections of 7Li and 12C with 198Pt at deep sub-barrier energies are reported to unravel the role of the entrance channel in the occurrence of fusion hindrance. The onset of fusion hindrance has been clearly observed in C12+Pt198 system but not in Li7+Pt198 system, within the measured energy range. Emergence of the hindrance, moving from lighter (6,7Li to heavier (12C, 16O projectiles is explained employing a model that considers a gradual transition from a sudden to adiabatic regime at low energies. The model calculation reveals a weak effect of the damping of coupling to collective motion for the present systems as compared to that obtained for systems with heavier projectiles.

  8. Evolution of fusion hindrance for asymmetric systems at deep sub-barrier energies

    Science.gov (United States)

    Shrivastava, A.; Mahata, K.; Pandit, S. K.; Nanal, V.; Ichikawa, T.; Hagino, K.; Navin, A.; Palshetkar, C. S.; Parkar, V. V.; Ramachandran, K.; Rout, P. C.; Kumar, Abhinav; Chatterjee, A.; Kailas, S.

    2016-04-01

    Measurements of fusion cross-sections of 7Li and 12C with 198Pt at deep sub-barrier energies are reported to unravel the role of the entrance channel in the occurrence of fusion hindrance. The onset of fusion hindrance has been clearly observed in 12C +198Pt system but not in 7Li +198Pt system, within the measured energy range. Emergence of the hindrance, moving from lighter (6,7Li) to heavier (12C, 16O) projectiles is explained employing a model that considers a gradual transition from a sudden to adiabatic regime at low energies. The model calculation reveals a weak effect of the damping of coupling to collective motion for the present systems as compared to that obtained for systems with heavier projectiles.

  9. Evolution of fusion hindrance for asymmetric systems at deep sub barrier energies

    CERN Document Server

    Shrivastavaa, A; Pandit, S K; Nanal, V; Ichikawa, T; Hagino, K; Navin, A; Palshetkar, C S; Parkar, V V; Ramachandran, K; Rout, P C; Kumar, Abhinav; Chatterjee, A; Kailas, S

    2016-01-01

    Measurements of fusion cross-sections of 7Li and 12C with 198Pt at deep sub-barrier energies are reported to unravel the role of the entrance channel in the occurrence of fusion hindrance. The onset of fusion hindrance has been clearly observed in 12C + 198Pt system but not in 7Li + 198Pt system, within the measured energy range. Emergence of the hindrance, moving from lighter (6,7Li) to heavier (12C,16O) projectiles is explained employing a model that considers a gradual transition from a sudden to adiabatic regime at low energies. The model calculation reveals a weak effect of the damping of coupling to collective motion for the present systems as compared to that obtained for systems with heavier projectiles.

  10. Nanofiber-based filters as novel barrier systems for nanomaterial exposure scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Faccini, M; Amantia, D; Vazquez-Campos, S; Aubouy, L [LEITAT Technological Center, Passeig 22 de Juliol, 218, 08221 Terrassa (Spain); Vaquero, C; Lopez de Ipina, J M, E-mail: mfaccini@leitat.org [Tecnalia, P.T. Alava - C/ Leonardo Da Vinci, 11, 01510 Minano (Alava) (Spain)

    2011-07-06

    In this article our latest advances in the development of efficient barrier systems against micro- and nano-particulate materials are presented. Nanofibrous polyamide 6 (PA6) mats were fabricated by electrospinning onto a nonwoven viscose substrate. The influence of electrospinning parameters including solution concentration, viscosity, and conductivity, were studied for the production of nonwovens with different fiber size distribution ranging from 74 to 261 nm in diameters. Moreover, the formation of nanowebs (30-40 nm) which are widely distributed among fibers was observed. By varying several process parameters, membranes with different thickness of the nanofiber layer and therefore air permeability and nanoparticle filtration efficiency were obtained.

  11. Nanofiber-based filters as novel barrier systems for nanomaterial exposure scenarios

    Science.gov (United States)

    Faccini, M.; Amantia, D.; Vázquez-Campos, S.; Vaquero, C.; López de Ipiña, J. M.; Aubouy, L.

    2011-07-01

    In this article our latest advances in the development of efficient barrier systems against micro- and nano-particulate materials are presented. Nanofibrous polyamide 6 (PA6) mats were fabricated by electrospinning onto a nonwoven viscose substrate. The influence of electrospinning parameters including solution concentration, viscosity, and conductivity, were studied for the production of nonwovens with different fiber size distribution ranging from 74 to 261 nm in diameters. Moreover, the formation of nanowebs (30-40 nm) which are widely distributed among fibers was observed. By varying several process parameters, membranes with different thickness of the nanofiber layer and therefore air permeability and nanoparticle filtration efficiency were obtained.

  12. Burden of Circulatory System Diseases and Ignored Barriers ofKnowledge Translation

    Directory of Open Access Journals (Sweden)

    Hamed-Basir Ghafouri

    2012-10-01

    Full Text Available Circulatory system disease raise third highest disability-adjusted life years among Iranians and ischemic cardiac diseases are main causes for such burden. Despite available evidences on risk factors of the disease, no effective intervention was implemented to control and prevent the disease. This paper non-systematically reviews available literature on the problem, solutions, and barriers of implementation of knowledge translation in Iran. It seems that there are ignored factors such as cultural and motivational issues in knowledge translation interventions but there are hopes for implementation of started projects and preparation of students as next generation of knowledge transferors.

  13. OVERCOMING THE METER BARRIER AND THE FORMATION OF SYSTEMS WITH TIGHTLY PACKED INNER PLANETS (STIPs)

    Energy Technology Data Exchange (ETDEWEB)

    Boley, A. C. [Department of Physics and Astronomy, The University of British Columbia, 6224 Agricultural Road, Vancouver, B.C. V6T 1Z1 (Canada); Morris, M. A. [Center for Meteorite Studies, Arizona State University, P.O. Box 876004, Tempe, AZ 88287-6004 (United States); Ford, E. B. [Center for Exoplanets and Habitable Worlds, The Pennsylvania State University, 525 Davey Laboratory, University Park, PA 16802 (United States)

    2014-09-10

    We present a solution to the long outstanding meter barrier problem in planet formation theory. As solids spiral inward due to aerodynamic drag, they will enter disk regions that are characterized by high temperatures, densities, and pressures. High partial pressures of rock vapor can suppress solid evaporation, and promote collisions between partially molten solids, allowing rapid growth. This process should be ubiquitous in planet-forming disks, which may be evidenced by the abundant class of Systems with Tightly packed Inner Planets discovered by the NASA Kepler Mission.

  14. Role of histaminergic system in blood-brain barrier dysfunction associated with neurological disorders.

    Science.gov (United States)

    Bañuelos-Cabrera, Ivette; Valle-Dorado, María Guadalupe; Aldana, Blanca Irene; Orozco-Suárez, Sandra Adela; Rocha, Luisa

    2014-11-01

    Blood-brain barrier (BBB) disruption has been associated with several acute and chronic brain disorders such as Alzheimer's disease, Parkinson's disease and epilepsy. This represents a critical situation because damaged integrity of the BBB is related to the influx of immune mediators, plasma proteins and other outside elements from blood to the central nervous system (CNS) that may trigger a cascade of events that leads to neuroinflammation. In this review, evidence that mast cells and the release of factors such as histamine play an important role in the neuroinflammatory process associated with brain disorders such as Alzheimer's disease, Parkinson's disease and epilepsy is presented.

  15. Engineered barrier system and waste package design concepts for a potential geologic repository at Yucca Mountain

    Energy Technology Data Exchange (ETDEWEB)

    Short, D.W.; Ruffner, D.J.; Jardine, L.J.

    1991-10-01

    We are using an iterative process to develop preliminary concept descriptions for the Engineered Barrier System and waste-package components for the potential geologic repository at Yucca Mountain. The process allows multiple design concepts to be developed subject to major constraints, requirements, and assumptions. Involved in the highly interactive and interdependent steps of the process are technical specialists in engineering, metallic and nonmetallic materials, chemistry, geomechanics, hydrology, and geochemistry. We have developed preliminary design concepts that satisfy both technical and nontechnical (e.g., programmatic or policy) requirements.

  16. Reactive Transport and Coupled THM Processes in Engineering Barrier Systems (EBS)

    Energy Technology Data Exchange (ETDEWEB)

    Steefel, Carl; Rutqvist, Jonny; Tsang, Chin-Fu; Liu, Hui-Hai; Sonnenthal, Eric; Houseworth, Jim; Birkholzer, Jens

    2010-08-31

    Geological repositories for disposal of high-level nuclear wastes generally rely on a multi-barrier system to isolate radioactive wastes from the biosphere. The multi-barrier system typically consists of a natural barrier system, including repository host rock and its surrounding subsurface environment, and an engineering barrier system (EBS). EBS represents the man-made, engineered materials placed within a repository, including the waste form, waste canisters, buffer materials, backfill and seals (OECD, 2003). EBS plays a significant role in the containment and long-term retardation of radionuclide release. EBS is involved in complex thermal, hydrogeological, mechanical, chemical and biological processes, such as heat release due to radionuclide decay, multiphase flow (including gas release due to canister corrosion), swelling of buffer materials, radionuclide diffusive transport, waste dissolution and chemical reactions. All these processes are related to each other. An in-depth understanding of these coupled processes is critical for the performance assessment (PA) for EBS and the entire repository. Within the EBS group of Used Fuel Disposition (UFD) Campaign, LBNL is currently focused on (1) thermal-hydraulic-mechanical-chemical (THMC) processes in buffer materials (bentonite) and (2) diffusive transport in EBS associated with clay host rock, with a long-term goal to develop a full understanding of (and needed modeling capabilities to simulate) impacts of coupled processes on radionuclide transport in different components of EBS, as well as the interaction between near-field host rock (e.g., clay) and EBS and how they effect radionuclide release. This final report documents the progress that LBNL has made in its focus areas. Specifically, Section 2 summarizes progress on literature review for THMC processes and reactive-diffusive radionuclide transport in bentonite. The literature review provides a picture of the state-of-the-art of the relevant research areas

  17. ARTIFICIAL NEURAL NETWORKS BASED GEARS MATERIAL SELECTION HYBRID INTELLIGENT SYSTEM

    Institute of Scientific and Technical Information of China (English)

    X.C. Li; W.X. Zhu; G. Chen; D.S. Mei; J. Zhang; K.M. Chen

    2003-01-01

    An artificial neural networks(ANNs) based gear material selection hybrid intelligent system is established by analyzing the individual advantages and weakness of expert system (ES) and ANNs and the applications in material select of them. The system mainly consists of tow parts: ES and ANNs. By being trained with much data samples,the back propagation (BP) ANN gets the knowledge of gear materials selection, and is able to inference according to user input. The system realizes the complementing of ANNs and ES. Using this system, engineers without materials selection experience can conveniently deal with gear materials selection.

  18. Optimization of the NiCrAl-Y/ZrO-Y2O3 thermal barrier system

    Science.gov (United States)

    Stecura, S.

    1985-01-01

    The effects of bond and thermal barrier coating compositions, thicknesses, and densities on air plasma spray deposited Ni-Cr-Al-Y/ZrO2-Y2O3 life were evaluated in cyclic furnace oxidation tests at temperatures from 1110 to 1220 C. An empirical relation was developed to give life as a function of the above parameters. The thermal barrier system tested which had the longest life consisted of Ni-35.0 wt% Cr-5.9 wt% Al-0.95 wt% Y bond coating and ZrO2-6.1 wt% Y2O3 thermal barrier coating.

  19. Smart parking barrier

    KAUST Repository

    Alharbi, Abdulrazaq M.

    2016-05-06

    Various methods and systems are provided for smart parking barriers. In one example, among others, a smart parking barrier system includes a movable parking barrier located at one end of a parking space, a barrier drive configured to control positioning of the movable parking barrier, and a parking controller configured to initiate movement of the parking barrier, via the barrier drive. The movable parking barrier can be positioned between a first position that restricts access to the parking space and a second position that allows access to the parking space. The parking controller can initiate movement of the movable parking barrier in response to a positive identification of an individual allowed to use the parking space. The parking controller can identify the individual through, e.g., a RFID tag, a mobile device (e.g., a remote control, smartphone, tablet, etc.), an access card, biometric information, or other appropriate identifier.

  20. Socio-cultural barriers to the development of a sustainable energy system - the case of hydrogen

    Energy Technology Data Exchange (ETDEWEB)

    Kjerulf Petersen, L.; Holst Andersen, A.

    2009-02-15

    Any transition to a more sustainable energy system, radically reducing greenhouse gas emissions, is bound to run in to a host of different barriers - technological and economic, but also socio-cultural. This will also be the case for any large-scale application of hydrogen as energy carrier, especially if the system is going to be based on renewable energy sources. The aim of these research notes is to review and discuss major socio-cultural barriers to new forms of energy supply in general and to hydrogen specifically. Reaching sufficient reductions in greenhouse gas emissions may require more than large-scale dissemination of renewable energy sources. Also reductions or moderations in energy demand may be necessary. Hence, a central point in the research note is to consider not only socio-cultural obstacles for changing technologies in energy production, distribution and consumption but also obstacles for changing the scale of energy consumption, i.e. moderating the growth in how much energy is consumed or even reducing consumption volumes. (au)

  1. Magnetic Materials: Novel Monitors of Long-Term Evolution of Engineered Barrier Systems

    Directory of Open Access Journals (Sweden)

    Simon L. Harley

    2016-12-01

    Full Text Available Most safety cases for the deep geological disposal of radioactive waste are reliant on the swelling of bentonite in the engineered barrier system as it saturates with groundwater. Assurance of safety therefore requires effective monitoring of bentonite saturation. The time- and fluid-dependent corrosion of synthetic magnets embedded in bentonite is demonstrated here to provide a novel and passive means of monitoring saturation. Experiments have been conducted at 70 °C in which neo magnets, AlNiCo magnets, and ferrite magnets have been reacted with saline (NaCl, KCl, CaCl2 solutions and alkaline fluids (NaOH, KOH, Ca(OH2 solutions; pH = 12 in the presence of bentonite. Nd-Fe-B magnets undergo extensive corrosion that results in a dramatic change from ferromagnetic to superparamagnetic behaviour concomitant with bentonite saturation. AlNiCo magnets in saline solutions show corrosion but only limited decreases in their magnetic intensities, and ferrite magnets are essentially unreactive on the experimental timescales, retaining their initial magnetic properties. For all magnets the impact of their corrosion on bentonite swelling is negligible; alteration of bentonite is essentially governed by the applied fluid composition. In principle, synthetic magnet arrays can, with further development, be designed and embedded in bentonite to monitor its fluid saturation without compromising the integrity of the engineered barrier system itself.

  2. Regulation of Copper Transport Crossing Brain Barrier Systems by Cu-ATPases: Effect of Manganese Exposure

    Science.gov (United States)

    Fu, Xue; Zhang, Yanshu; Jiang, Wendy; Monnot, Andrew Donald; Bates, Christopher Alexander; Zheng, Wei

    2014-01-01

    Regulation of cellular copper (Cu) homeostasis involves Cu-transporting ATPases (Cu-ATPases), i.e., ATP7A and ATP7B. The question as to how these Cu-ATPases in brain barrier systems transport Cu, i.e., toward brain parenchyma, cerebrospinal fluid (CSF), or blood, remained unanswered. This study was designed to characterize roles of Cu-ATPases in regulating Cu transport at the blood-brain barrier (BBB) and blood-CSF barrier (BCB) and to investigate how exposure to toxic manganese (Mn) altered the function of Cu-ATPases, thereby contributing to the etiology of Mn-induced parkinsonian disorder. Studies by quantitative real-time RT-PCR (qPCR), Western blot, and immunocytochemistry revealed that both Cu-ATPases expressed abundantly in BBB and BCB. Transport kinetic studies by in situ brain infusion and ventriculo-cisternal (VC) perfusion in Sprague Dawley rat suggested that the BBB was a major site for Cu entry into brain, whereas the BCB was a predominant route for Cu efflux from the CSF to blood. Confocal evidence showed that the presence of excess Cu or Mn in the choroid plexus cells led to ATP7A relocating toward the apical microvilli facing the CSF, but ATP7B toward the basolateral membrane facing blood. Mn exposure inhibited the production of both Cu-ATPases. Collectively, these data suggest that Cu is transported by the BBB from the blood to brain, which is mediated by ATP7A in brain capillary. By diffusion, Cu ions move from the interstitial fluid into the CSF, where they are taken up by the BCB. Within the choroidal epithelial cells, Cu ions are transported by ATP7B back to the blood. Mn exposure alters these processes, leading to Cu dyshomeostasis-associated neuronal injury. PMID:24614235

  3. Degradation of Organic Compounds by Active Species Sprayed in a Dielectric Barrier Corona Discharge System

    Institute of Scientific and Technical Information of China (English)

    LI Jie; SONG Ling; LIU Qiang; QU Guangzhou; LI Guofeng; WU Yan

    2009-01-01

    Investigation was made into the degradation of organic compounds by a dielectric barrier corona discharge (DBCD) system. The DBCD, consisting of a quartz tube, a concentric high voltage electrode and a net wrapped to the external wall (used as ground electrode), was introduced to generate active species which were sprayed into the organic solution through an aerator fixed on the bottom of the tube. The effect of four factors-the discharge voltage, gas flow rate, solution conductivity, and pH of wastewater, on the degradation efficiency of phenol was assessed. The obtained results demonstrated that this process was an effective method for phenol degradation. The degradation rate was enhanced with the increase in power supplied. The degradation efficiency in alkaline conditions was higher than those in acid and neutral conditions.The optimal gas flow rate for phenol degradation in the system was 1.6 L/min, while the solution conductivity had little effect on the degradation.

  4. Comparing the Dimensions of Modern and Ancient Barrier Island Systems to Understand Controls on Preservation

    Science.gov (United States)

    Mulhern, J.; Johnson, C. L.; Stright, L.

    2015-12-01

    Commonly assumed to have low preservation potential, barrier islands are rarely interpreted in the rock record, and there is little consensus on the terminology and depositional models related to their interpretation. Prevalent on transgressive coastlines, the dimensions of modern barriers are used as analogs for the ancient; however, ancient examples are complicated by post-depositional processes, including thickening through amalgamation and removal by ravinement. Contrasting the dimensions of modern and ancient examples lends insight into the development and preservation of transgressive deposits, improving the ability to predict the size and distribution of barrier island sand bodies in the rock record as well as understanding the variables that control their architecture. Interpretation of barrier island deposits from the John Henry Member (Cretaceous Straight Cliffs Fm., Kaiparowits Plateau, southern Utah) motivated an investigation into both ancient and modern barrier islands. Traditional sequence stratigraphic models predict thin condensed deposition during transgression, not accounting for possible thick and laterally extensive accumulations of barrier island deposits. More recent models recognize the possible complexity and heterogeneity of transgressive deposits and the potential for barrier island accumulation. To better understand the relationship between modern and ancient barrier islands, the length (along strike), width (dip direction) and thickness (vertical) of >20 modern and >30 ancient barrier islands were compared. Ancient dimensions were gathered from the literature, while modern dimensions were aggregated from literature and a database of modern barrier islands currently being developed. Initial results suggest that ancient barrier island deposits record the motion of the shoreline during transgression. Ancient barriers are ~2-8 times wider and ~2-3 times thicker than modern islands. The dynamics of barrier island migration and sediment

  5. Regulated competition in health care: Switching and barriers to switching in the Dutch health insurance system

    Directory of Open Access Journals (Sweden)

    Rijken Mieke

    2011-05-01

    Full Text Available Abstract Background In 2006, a number of changes in the Dutch health insurance system came into effect. In this new system mobility of insured is important. The idea is that insured switch insurers because they are not satisfied with quality of care and the premium of their insurance. As a result, insurers will in theory strive for a better balance between price and quality. The Dutch changes have caught the attention, internationally, of both policy makers and researchers. In our study we examined switching behaviour over three years (2007-2009. We tested if there are differences in the numbers of switchers between groups defined by socio-demographic and health characteristics and between the general population and people with chronic illness or disability. We also looked at reasons for (not-switching and at perceived barriers to switching. Methods Switching behaviour and reasons for (not-switching were measured over three years (2007-2009 by sending postal questionnaires to members of the Dutch Health Care Consumer Panel and of the National Panel of people with Chronic illness or Disability. Data were available for each year and for each panel for at least 1896 respondents - a response of between 71% and 88%. Results The percentages of switchers are low; 6% in 2007, 4% in 2008 and 3% in 2009. Younger and higher educated people switch more often than older and lower educated people and women switch more often than men. There is no difference in the percentage of switchers between the general population and people with chronic illness or disability. People with a bad self-perceived health, and chronically ill and disabled, perceive more barriers to switching than others. Conclusion The percentages of switchers are comparable to the old system. Switching is not based on quality of care and thus it can be questioned whether it will lead to a better balance between price and quality. Although there is no difference in the frequency of switching

  6. Quantifying system safety: A comparison of the SBOAT & Safety Barrier Manager tools

    DEFF Research Database (Denmark)

    Hansen, Zaza Nadja Lee; Duijm, Nijs Jan; Markert, Frank;

    2015-01-01

    This paper presents two software tools for analyzing safety risks, SBOAT (Stochastic BPMN Optimisation and Analysis Tool) and SBM (SafetyBarrierManagerr). SBOAT employs principles from stochastic model checking to allow for the quantitative verification of workflows. SBM supports the creation...... of valid safety-barrier diagrams and allows the quantitative analysis of the probability of all possible end states of the barrier diagram, i.e. the outcomes if one or several of the barriers fail to perform their barrier function. We compare the foundations of these tools and describe how they can be used...

  7. Effectiveness of compacted soil liner as a gas barrier layer in the landfill final cover system.

    Science.gov (United States)

    Moon, Seheum; Nam, Kyoungphile; Kim, Jae Young; Hwan, Shim Kyu; Chung, Moonkyung

    2008-01-01

    A compacted soil liner (CSL) has been widely used as a single barrier layer or a part of composite barrier layer in the landfill final cover system to prevent water infiltration into solid wastes for its acceptable hydraulic permeability. This study was conducted to test whether the CSL was also effective in prohibiting landfill gas emissions. For this purpose, three different compaction methods (i.e., reduced, standard, and modified Proctor methods) were used to prepare the soil specimens, with nitrogen as gas, and with water and heptane as liquid permeants. Measured gas permeability ranged from 2.03 x 10(-10) to 4.96 x 10(-9) cm(2), which was a magnitude of two or three orders greater than hydraulic permeability (9.60 x 10(-13) to 1.05 x 10(-11) cm(2)). The difference between gas and hydraulic permeabilities can be explained by gas slippage, which makes gas more permeable, and by soil-water interaction, which impedes water flow and then makes water less permeable. This explanation was also supported by the result that a liquid permeability measured with heptane as a non-polar liquid was similar to the intrinsic gas permeability. The data demonstrate that hydraulic requirement for the CSL is not enough to control the gas emissions from a landfill.

  8. Ultrathin, transferred layers of thermally grown silicon dioxide as biofluid barriers for biointegrated flexible electronic systems

    Science.gov (United States)

    Fang, Hui; Zhao, Jianing; Yu, Ki Jun; Song, Enming; Barati Farimani, Amir; Chiang, Chia-Han; Jin, Xin; Xue, Yeguang; Xu, Dong; Du, Wenbo; Seo, Kyung Jin; Zhong, Yiding; Yang, Zijian; Won, Sang Min; Fang, Guanhua; Choi, Seo Woo; Chaudhuri, Santanu; Huang, Yonggang; Ashraful Alam, Muhammad; Viventi, Jonathan; Aluru, N. R.; Rogers, John A.

    2016-10-01

    Materials that can serve as long-lived barriers to biofluids are essential to the development of any type of chronic electronic implant. Devices such as cardiac pacemakers and cochlear implants use bulk metal or ceramic packages as hermetic enclosures for the electronics. Emerging classes of flexible, biointegrated electronic systems demand similar levels of isolation from biofluids but with thin, compliant films that can simultaneously serve as biointerfaces for sensing and/or actuation while in contact with the soft, curved, and moving surfaces of target organs. This paper introduces a solution to this materials challenge that combines (i) ultrathin, pristine layers of silicon dioxide (SiO2) thermally grown on device-grade silicon wafers, and (ii) processing schemes that allow integration of these materials onto flexible electronic platforms. Accelerated lifetime tests suggest robust barrier characteristics on timescales that approach 70 y, in layers that are sufficiently thin (less than 1 μm) to avoid significant compromises in mechanical flexibility or in electrical interface fidelity. Detailed studies of temperature- and thickness-dependent electrical and physical properties reveal the key characteristics. Molecular simulations highlight essential aspects of the chemistry that governs interactions between the SiO2 and surrounding water. Examples of use with passive and active components in high-performance flexible electronic devices suggest broad utility in advanced chronic implants.

  9. Monitoring Local Strain in a Thermal Barrier Coating System Under Thermal Mechanical Gas Turbine Operating Conditions

    Science.gov (United States)

    Manero, Albert; Sofronsky, Stephen; Knipe, Kevin; Meid, Carla; Wischek, Janine; Okasinski, John; Almer, Jonathan; Karlsson, Anette M.; Raghavan, Seetha; Bartsch, Marion

    2015-07-01

    Advances in aircraft and land-based turbine engines have been increasing the extreme loading conditions on traditional engine components and have incited the need for improved performance with the use of protective coatings. These protective coatings shield the load-bearing super alloy blades from the high-temperature combustion gases by creating a thermal gradient over their thickness. This addition extends the life and performance of blades. A more complete understanding of the behavior, failure mechanics, and life expectancy for turbine blades and their coatings is needed to enhance and validate simulation models. As new thermal-barrier-coated materials and deposition methods are developed, strides to effectively test, evaluate, and prepare the technology for industry deployment are of paramount interest. Coupling the experience and expertise of researchers at the University of Central Florida, The German Aerospace Center, and Cleveland State University with the world-class synchrotron x-ray beam at the Advanced Photon Source in Argonne National Laboratory, the synergistic collaboration has yielded previously unseen measurements to look inside the coating layer system for in situ strain measurements during representative service loading. These findings quantify the in situ strain response on multilayer thermal barrier coatings and shed light on the elastic and nonelastic properties of the layers and the role of mechanical load and internal cooling variations on the response. The article discusses the experimental configuration and development of equipment to perform in situ strain measurements on multilayer thin coatings and provides an overview of the achievements thus far.

  10. Rheumatologists' perception of systemic lupus erythematosus quality indicators: significant interest and perceived barriers.

    Science.gov (United States)

    Casey, Carolyn; Chung, Cecilia P; Crofford, Leslie J; Barnado, April

    2017-01-01

    Differences in quality of care may contribute to health disparities in systemic lupus erythematosus (SLE). Studies show low physician adherence rates to the SLE quality indicators but do not assess physician perception of SLE quality indicators or quality improvement. Using a cross-sectional survey of rheumatologists in the southeastern USA, we assessed the perception and involvement of rheumatologists in quality improvement and the SLE quality indicators. Using electronic mail, an online survey of 32 questions was delivered to 568 rheumatologists. With a response rate of 19% (n = 106), the majority of participants were male, Caucasian, with over 20 years of experience, and seeing adult patients in an academic setting. Participants had a positive perception toward quality improvement (81%) with a majority responding that the SLE quality indicators would significantly impact quality of care (54%). While 66% of respondents were familiar with the SLE quality indicators, only 18% of respondents reported using them in everyday practice. The most commonly reported barrier to involvement in quality improvement and the SLE quality indicators was time. Rheumatologists had a positive perception of the SLE quality indicators and agreed that use of the quality indicators could improve quality of care in SLE; however, they identified time as a barrier to implementation. Future studies should investigate methods to increase use of the SLE quality indicators.

  11. A Fast Adaptive Receive Antenna Selection Method in MIMO System

    Directory of Open Access Journals (Sweden)

    Chaowei Wang

    2013-01-01

    Full Text Available Antenna selection has been regarded as an effective method to acquire the diversity benefits of multiple antennas while potentially reduce hardware costs. This paper focuses on receive antenna selection. According to the proportion between the numbers of total receive antennas and selected antennas and the influence of each antenna on system capacity, we propose a fast adaptive antenna selection algorithm for wireless multiple-input multiple-output (MIMO systems. Mathematical analysis and numerical results show that our algorithm significantly reduces the computational complexity and memory requirement and achieves considerable system capacity gain compared with the optimal selection technique in the same time.

  12. Implementation of Computer Assisted Test Selection System in Local Governments

    Directory of Open Access Journals (Sweden)

    Abdul Azis Basri

    2016-05-01

    Full Text Available As an evaluative way of selection of civil servant system in all government areas, Computer Assisted Test selection system was started to apply in 2013. In phase of implementation for first time in all areas in 2014, this system selection had trouble in several areas, such as registration procedure and passing grade. The main objective of this essay was to describe implementation of new selection system for civil servants in the local governments and to seek level of effectiveness of this selection system. This essay used combination of study literature and field survey which data collection was made by interviews, observations, and documentations from various sources, and to analyze the collected data, this essay used reduction, display data and verification for made the conclusion. The result of this essay showed, despite there a few parts that be problem of this system such as in the registration phase but almost all phases of implementation of CAT selection system in local government areas can be said was working clearly likes in preparation, implementation and result processing phase. And also this system was fulfilled two of three criterias of effectiveness for selection system, they were accuracy and trusty. Therefore, this selection system can be said as an effective way to select new civil servant. As suggestion, local governments have to make prime preparation in all phases of test and make a good feedback as evaluation mechanism and together with central government to seek, fix and improve infrastructures as supporting tool and competency of local residents.

  13. 46 CFR 108.404 - Selection of fire detection system.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Selection of fire detection system. 108.404 Section 108.404 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Fire Extinguishing Systems § 108.404 Selection of fire detection system. (a) If...

  14. Protection of blood retinal barrier and systemic vasculature by insulin-like growth factor binding protein-3.

    Directory of Open Access Journals (Sweden)

    Yagna P R Jarajapu

    Full Text Available Previously, we showed that insulin growth factor (IGF-1 binding protein-3 (IGFBP-3, independent of IGF-1, reduces pathological angiogenesis in a mouse model of the oxygen-induced retinopathy (OIR. The current study evaluates novel endothelium-dependent functions of IGFBP-3 including blood retinal barrier (BRB integrity and vasorelaxation. To evaluate vascular barrier function, either plasmid expressing IGFBP-3 under the regulation of an endothelial-specific promoter or a control plasmid was injected into the vitreous humor of mouse pups (P1 and compared to the non-injected eyes of the same pups undergoing standard OIR protocol. Prior to sacrifice, the mice were given an injection of horseradish peroxidase (HRP. IGFBP-3 plasmid-injected eyes displayed near-normal vessel morphology and enhanced vascular barrier function. Further, in vitro IGFBP-3 protects retinal endothelial cells from VEGF-induced loss of junctional integrity by antagonizing the dissociation of the junctional complexes. To assess the vasodilatory effects of IGFBP-3, rat posterior cerebral arteries were examined in vitro. Intraluminal IGFBP-3 decreased both pressure- and serotonin-induced constrictions by stimulating nitric oxide (NO release that were blocked by L-NAME or scavenger receptor-B1 neutralizing antibody (SRB1-Ab. Both wild-type and IGF-1-nonbinding mutant IGFBP-3 (IGFBP-3NB stimulated eNOS activity/NO release to a similar extent in human microvascular endothelial cells (HMVECs. NO release was neither associated with an increase in intracellular calcium nor decreased by Ca(2+/calmodulin-dependent protein kinase II (CamKII blockade; however, dephosphorylation of eNOS-Thr(495 was observed. Phosphatidylinositol 3-kinase (PI3K activity and Akt-Ser(473 phosphorylation were both increased by IGFBP-3 and selectively blocked by the SRB1-Ab or PI3K blocker LY294002. In conclusion, IGFBP-3 mediates protective effects on BRB integrity and mediates robust NO release to stimulate

  15. Changes in skin barrier during treatment with systemic alitretinoin: focus on skin susceptibility and stratum corneum ceramides

    DEFF Research Database (Denmark)

    Jungersted, J.M.; Høgh, Julie Kaae; Hellgren, Lars;

    2010-01-01

    the effect of systemic alitretinoin on skin barrier function and response to irritants, a secondary objective was to determine if changes occur in the lipid profile of stratum corneum after treatment with systemic alitretinoin. We conducted an open clinical intervention study on eight people ascribed...

  16. On the near-barrier fusion of the proton-halo {sup 8}B + {sup 58}Ni system

    Energy Technology Data Exchange (ETDEWEB)

    Rangel, J.; Lubian, J.; Gomes, P.R.S. [Universidade Federal Fluminense, Instituto de Fisica, Gragoata, Niteroi, R.J. (Brazil); Carlson, B.V. [Instituto Tecnologico de Aeronautica, Departamento de Fisica, Sao Paulo (Brazil); Chamon, L.C. [Universidade de Sao Paulo, Instituto de Fisica, CP 66318, Sao Paulo (Brazil); Gomez Camacho, A. [Instituto Nacional de Investigaciones, Departamento de Aceleradores, Apartado Postal 18-1027, C.P. 11801, Mexico, D.F. (Mexico)

    2013-05-15

    We have performed two independent calculations, without any free parameter, to predict the near-barrier fusion cross section for the proton-halo {sup 8}B + {sup 58}Ni system, for which data were recently reported. Standard coupled channel calculations predict fusion cross sections smaller than the data, while CDCC calculations for the absorption cross section (fusion + transfer + inelastic cross sections) agree with the data above the barrier, although transfer cross sections are calculated to have non-negligible cross section at this energy regime. At sub-barrier energies, region where transfer cross sections are particularly important, the CDCC calculations overpredict the data. The fusion data of the {sup 8}B + {sup 58}Ni system fail to follow the systematics of other weakly bound nuclei and the UFF curve and do not agree with the fusion data of the {sup 8}B + {sup 28}Si system. We try to explain this anomalous behaviour. (orig.)

  17. Creep Behavior of Hafnia and Ytterbium Silicate Environmental Barrier Coating Systems on SiC/SiC Ceramic Matrix Composites

    Science.gov (United States)

    Zhu, Dongming; Fox, Dennis S.; Ghosn, Louis J.; Harder, Bryan

    2011-01-01

    Environmental barrier coatings will play a crucial role in future advanced gas turbine engines because of their ability to significantly extend the temperature capability and stability of SiC/SiC ceramic matrix composite (CMC) engine components, thus improving the engine performance. In order to develop high performance, robust coating systems for engine components, appropriate test approaches simulating operating temperature gradient and stress environments for evaluating the critical coating properties must be established. In this paper, thermal gradient mechanical testing approaches for evaluating creep and fatigue behavior of environmental barrier coated SiC/SiC CMC systems will be described. The creep and fatigue behavior of Hafnia and ytterbium silicate environmental barrier coatings on SiC/SiC CMC systems will be reported in simulated environmental exposure conditions. The coating failure mechanisms will also be discussed under the heat flux and stress conditions.

  18. A bioindicator system for water quality on inshore coral reefs of the Great Barrier Reef.

    Science.gov (United States)

    Fabricius, Katharina E; Cooper, Timothy F; Humphrey, Craig; Uthicke, Sven; De'ath, Glenn; Davidson, Johnston; LeGrand, Hélène; Thompson, Angus; Schaffelke, Britta

    2012-01-01

    Responses of bioindicator candidates for water quality were quantified in two studies on inshore coral reefs of the Great Barrier Reef (GBR). In Study 1, 33 of the 38 investigated candidate indicators (including coral physiology, benthos composition, coral recruitment, macrobioeroder densities and FORAM index) showed significant relationships with a composite index of 13 water quality variables. These relationships were confirmed in Study 2 along four other water quality gradients (turbidity and chlorophyll). Changes in water quality led to multi-faceted shifts from phototrophic to heterotrophic benthic communities, and from diverse coral dominated communities to low-diversity communities dominated by macroalgae. Turbidity was the best predictor of biota; hence turbidity measurements remain essential to directly monitor water quality on the GBR, potentially complemented by our final calibrated 12 bioindicators. In combination, this bioindicator system may be used to assess changes in water quality, especially where direct water quality data are unavailable.

  19. Mechanisms governing the interfacial delamination of thermal barrier coating system with double ceramic layers

    Science.gov (United States)

    Xu, Rong; Fan, Xueling; Wang, T. J.

    2016-05-01

    A systematic study of factors affecting the interfacial delamination of thermal barrier coating system (TBCs) with double ceramic layers (DCL) is presented. Crack driving forces for delaminations at two weak interfaces are examined. The results show that a thicker outermost ceramic layer can induce dramatic increase in crack driving force and make the interface between two ceramic coatings become more prone to delamination. The behavior is shown to be more prominent in TBCs with stiffer outmost coating. The thickness ratio of two ceramic layers is an important parameter for controlling the failure mechanisms and determining the lifetime of DCL TBCs under inservice condition. By accounting for the influences of thickness ratio of two ceramic layers and interfacial fracture toughnesses of two involved interfaces, the fracture mechanism map of DCL TBCs has been constructed, in which different failure mechanisms are identified. The results quanlitatively agree with the aviliable experimental data.

  20. Evaluation of the Lifetime and Thermal Conductivity of Dysprosia-Stabilized Thermal Barrier Coating Systems

    Science.gov (United States)

    Curry, Nicholas; Markocsan, Nicolaie; Östergren, Lars; Li, Xin-Hai; Dorfman, Mitch

    2013-08-01

    The aim of this study was the further development of dysprosia-stabilized zirconia coatings for gas turbine applications. The target for these coatings was a longer lifetime and higher insulating performance compared to today's industrial standard thermal barrier coating. Two morphologies of ceramic top coat were studied: one using a dual-layer system and the second using a polymer to generate porosity. Evaluations were carried out using a laser flash technique to measure thermal properties. Lifetime testing was conducted using thermo-cyclic fatigue testing. Microstructure was assessed with SEM and Image analysis was used to characterize porosity content. The results show that coatings with an engineered microstructure give performance twice that of the present reference coating.

  1. Reuse and recycling of secondary effluents in refineries employing advanced multi-barrier systems.

    Science.gov (United States)

    Lahnsteiner, J; Mittal, R

    2010-01-01

    In this paper the reclamation and reuse of municipal secondary effluents, as well as the reclamation and recycling of refinery secondary effluents, are technically and economically evaluated. It is shown that both practices are feasible and sustainable, and that the reclamation costs depend largely on specific circumstances such as legal requirements, price policy, reuse application, raw water composition, etc. The reclaimed water is reused, or respectively recycled, as boiler make-up. Therefore both reclamation plants employ advanced multi-barrier systems including ultra-filtration and reverse osmosis. The employed processes have shown excellent performance with regard to the removal of critical parameters such as silica. For example, this parameter was reduced from 13 mg/l in the raw water to 7 μg/l in the boiler make-up.

  2. Electro-Catalysis System for Biodiesel Synthesis from Palm Oil over Dielectric-Barrier Discharge Plasma Reactor

    Directory of Open Access Journals (Sweden)

    Istadi Istadi

    2014-07-01

    Full Text Available Biodiesel synthesis reaction routes from palm oil using plasma electro-catalysis process over Dielectric-Barrier Discharge (DBD plasma reactor were studied. The study was focused on finding possible reaction mechanism route during plasma electro-catalysis process. The prediction was performed based on the changes of Gas Chromatography Mass Spectrometer (GC-MS and Fourier Transform Infra Red (FT-IR analyses to the biodiesel products with respect to time length of plasma treatment. It was found that main reaction mechanism occurred in the plasma electro-catalysis system was non-thermal pyrolysis rather than transesterification. The main reactions within the plasma treatment were due to collision between high energetic electrons (supplied from high voltage power supply through high voltage electrode and the reaction mixtures. The high energetic electrons affected the electrons pair of covalent bonding to be excited or dissociated even ionized at higher energy. Therefore, this plasma electro-catalysis system was promising for biodiesel synthesis from vegetable oils due to only very short time reaction was needed, even no need a catalyst, no soap formation, and no glycerol by-product. This system could produce fatty acid methyl ester yield of 75.65% at 120 seconds and other possible chemicals, such as alkynes, alkanes, esters, carboxylic acid, and aldehydes. However, during the plasma process, the reaction mechanisms were still difficult to be controlled due the action of available high energetic electrons. The advanced studies on how to control the reaction mechanism selectively in the plasma electro-catalysis will be published elsewhere. © 2014 BCREC UNDIP. All rights reservedReceived: 23rd January 2014; Revised: 20th March 2014; Accepted: 23rd March 2014[How to Cite: Istadi, I., Yudhistira, A.D., Anggoro, D.D., Buchori, L. (2014. Electro-Catalysis System for Biodiesel Synthesis from Palm Oil over Dielectric-Barrier Discharge Plasma Reactor

  3. Barriers to sustainable tuberculosis control in the Russian Federation health system.

    Science.gov (United States)

    Atun, R. A.; Samyshkin, Y. A.; Drobniewski, F.; Skuratova, N. M.; Gusarova, G.; Kuznetsov, S. I.; Fedorin, I. M.; Coker, R. J.

    2005-01-01

    The Russian Federation has the eleventh highest tuberculosis burden in the world in terms of the total estimated number of new cases that occur each year. In 2003, 26% of the population was covered by the internationally recommended control strategy known as directly observed treatment (DOT) compared to an overall average of 61% among the 22 countries with the highest burden of tuberculosis. The Director-General of WHO has identified two necessary starting points for the scaling-up of interventions to control emerging infectious diseases. These are a comprehensive engagement with the health system and a strengthening of the health system. The success of programmes aimed at controlling infectious diseases is often determined by constraints posed by the health system. We analyse and evaluate the impact of the arrangements for delivering tuberculosis services in the Russian Federation, drawing on detailed analyses of barriers and incentives created by the organizational structures, and financing and provider-payment systems. We demonstrate that the systems offer few incentives to improve the efficiency of services or the effectiveness of tuberculosis control. Instead, the system encourages prolonged supervision through specialized outpatient departments in hospitals (known as dispensaries), multiple admissions to hospital and lengthy hospitalization. The implementation, and expansion and sustainability of WHO-approved methods of tuberculosis control in the Russian Federation are unlikely to be realized under the prevailing system of service delivery. This is because implementation does not take into account the wider context of the health system. In order for the control programme to be sustainable, the health system will need to be changed to enable services to be reconfigured so that incentives are created to reward improvements in efficiency and outcomes. PMID:15798846

  4. An Automated Recommender System for Course Selection

    Directory of Open Access Journals (Sweden)

    Amer Al-Badarenah

    2016-03-01

    Full Text Available Most of electronic commerce and knowledge management` systems use recommender systems as the underling tools for identifying a set of items that will be of interest to a certain user. Collaborative recommender systems recommend items based on similarities and dissimilarities among users’ preferences. This paper presents a collaborative recommender system that recommends university elective courses to students by exploiting courses that other similar students had taken. The proposed system employs an association rules mining algorithm as an underlying technique to discover patterns between courses. Experiments were conducted with real datasets to assess the overall performance of the proposed approach.

  5. Conservation on international boundaries: the impact of security barriers on selected terrestrial mammals in four protected areas in Arizona, USA.

    Directory of Open Access Journals (Sweden)

    Jamie W McCallum

    Full Text Available Several thousand terrestrial protected areas (PAs lie on international boundaries. Because international boundaries can be focal points for trade, illegal activity and development, such PAs can be vulnerable to a range of anthropogenic threats. There is an increasing trend towards the erection of international boundary infrastructure (including fences, barriers and ditches in many parts of the world, which may reduce the risk of these anthropogenic threats to some PAs. However this may restrict home range and access to resources for some native species. We sought to understand the impacts of these two different types of threat by using camera traps to measure the activity level of humans, native and invasive mammals in four US PAs on the Mexican international boundary. Comparisons were made between treatment areas with barriers and those without. Results showed that puma and coati were more likely to appear in treatment areas without barriers, whereas humans were not observed more frequently in one treatment area over another. The suggestion is that the intermittent fencing present in this part of the world does affect some native species, but does not necessarily restrict the movement of humans (including illegal migrants, who may negatively impact native species.

  6. Scheduler for multiprocessor system switch with selective pairing

    Energy Technology Data Exchange (ETDEWEB)

    Gara, Alan; Gschwind, Michael Karl; Salapura, Valentina

    2015-01-06

    System, method and computer program product for scheduling threads in a multiprocessing system with selective pairing of processor cores for increased processing reliability. A selective pairing facility is provided that selectively connects, i.e., pairs, multiple microprocessor or processor cores to provide one highly reliable thread (or thread group). The method configures the selective pairing facility to use checking provide one highly reliable thread for high-reliability and allocate threads to corresponding processor cores indicating need for hardware checking. The method configures the selective pairing facility to provide multiple independent cores and allocate threads to corresponding processor cores indicating inherent resilience.

  7. Fabrication of double barrier structures in single layer c-Si-QDs/a-SiOx films for realization of energy selective contacts for hot carrier solar cells

    Science.gov (United States)

    Kar, Debjit; Das, Debajyoti

    2017-01-01

    Thin films of c-Si-QDs embedded in an a-SiOx dielectric matrix forming arrays of double barrier structures have been fabricated by reactive rf-magnetron sputtering at ˜400 °C, without post-deposition annealing. The formation of larger size c-Si-QDs of reduced number density in homogeneous distribution within a less oxygenated a-SiOx matrix at higher plasma pressure introduces systematic widening of the average periodic distance between the adjacent `c-Si-QDs in a-SiOx', as obtained by X-ray reflectivity and transmission electron microscopy studies. A wave-like pattern in the J-E characteristics identifies the formation of periodic double-barrier structures along the path of the movement of charge carriers across the QDs and that those are originated by the a-SiOx dielectric matrix around the c-Si-QDs. A finite distribution of the size of c-Si-QDs introduces a broadening of the current density peak and simultaneously originates the negative differential resistance-like characteristics, which have suitable applications in the energy selective contacts that act as energy filters for hot carrier solar cells. A simple yet effective process technology has been demonstrated. Further initiative on tuning the energy selectivity by reducing the size and narrowing the size-distribution of Si-QDs can emerge superior energy selective contacts for hot carrier solar cells, paving ground for accomplishing all-Si solar cells.

  8. Analysis of the storage system in the selected company

    OpenAIRE

    BÄUML, Vítězslav

    2014-01-01

    The main aim of the thesis is an analysis the stock system and storage system of a selected company with the focus on material and information flow, storage processes, logistics costs and related logistics indexes.

  9. Evolution of an intermittent lagoon-barrier system with rising sea level: observations and projections from the Muni-Pomadze lagoon, Ghana

    Science.gov (United States)

    Davies-Vollum, Sian

    2016-04-01

    Intermittently closed lagoon-barrier systems are a transitory environment between land and sea that are influenced by fluvial and marine processes as well as human activities. Fluvial processes dominate most of the time, when the barrier is closed. However, when the barrier is breached an ephemeral connection between the lagoon and the ocean develops and estuarine-like conditions ensue. As sea level rises, the evolution of these systems from intermittently closed to open is dependent on multiple processes including barrier breaching, fragmentation and overwashing. Human intervention, often to prevent flooding, also has an impact. The Muni-Pomadze lagoon in central Ghana is a small, intermittently closed lagoon-barrier system that supports a local fishing community. A beach-barrier separates the lagoon from the ocean, impounding river water and sediment behind it for most of the year. At the end of a rainy season the barrier may be breached, either naturally or by human intervention to prevent flooding of dwellings on the barrier. Field observation, digital mapping and GIS analysis of the shoreline has enabled an understanding of how the barrier is evolving with rising sea level. The shore face of the barrier has shifted landwards with an average retreat rate of 0.22 m/yr. Small washover fans, developed at low points along the lagoon side of the barrier have developed. However, aerial photos reveal that these fans have remained stable since 1972 (earliest available air photos). The small size and stability of these fans suggests that overwashing is not an important factor in the evolution of the barrier and that the barrier is being eroded rather not moving landward. Erosion is particularly prevalent at the breach end of the barrier with an average rate of loss of 3 metres per year and palm trees that were providing stability to the barrier have been washed away. Unconsolidated sands forming a transient, spit-like feature have replaced the stable barrier, which

  10. Risk analysis of the governance system affecting outcomes in the Great Barrier Reef.

    Science.gov (United States)

    Dale, Allan P; Vella, Karen; Pressey, Robert L; Brodie, Jon; Gooch, Margaret; Potts, Ruth; Eberhard, Rachel

    2016-12-01

    The state and trend of the Great Barrier Reef's (GBR's) ecological health remains problematic, influencing United Nations Educational, Scientific and Cultural Organization (UNESCO) statements regarding GBR governance. While UNESCO's concerns triggered separate strategic assessments by the Australian and Queensland governments, there has been no independent and integrated review of the key risks within the overall system of governance influencing GBR outcomes. As a case study of international significance, this paper applies Governance Systems Analysis (GSA), a novel analytical framework that identifies the governance themes, domains and subdomains most likely to influence environmental and socio-economic outcomes in complex natural systems. This GBR-focussed application of GSA identifies governance subdomains that present high, medium, or low risk of failure to produce positive outcomes for the Reef. This enabled us to determine that three "whole of system" governance problems could undermine GBR outcomes. First, we stress the integrative importance of the Long Term Sustainability Plan (LTSP) Subdomain. Sponsored by the Australian and Queensland governments, this subdomain concerns the primary institutional arrangements for coordinated GBR planning and delivery, but due to its recent emergence, it faces several internal governance challenges. Second, we find a major risk of implementation failure in the achievement of GBR water quality actions due to a lack of system-wide focus on building strong and stable delivery systems at catchment scale. Finally, we conclude that the LTSP Subdomain currently has too limited a mandate/capacity to influence several high-risk subdomains that have not been, but must be more strongly aligned with Reef management (e.g. the Greenhouse Gas Emission Management Subdomain). Our analysis enables exploration of governance system reforms needed to address environmental trends in the GBR and reflects on the potential application of GSA in

  11. The system of employees motivation in a selected company

    OpenAIRE

    BEEROVÁ, Petra

    2014-01-01

    The system of employees motivation in a selected company is the title of this thesis that closely analyzes the system of employees motivation in a selected company and outlines some suggestions that could improve the management and performance in this area. Moreover, the focus is placed towards the motivation of employees in the workplace.

  12. HF Detecting Radar and Communication Frequency Selection System

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Real time communication (RTC) frequency selecting system is used to the maximum usable frequency (MUF) between two communication points, then finds the best frequency between 0. 85 MUF and 1.0MUF. Determination of electric wave delay is mostly introduced, and of MUF values, the form of frequencycontrolling code and relative interface circuits in the frequency selecting system are introduced in detail.

  13. Discrete Solitary Waves in Systems with Nonlocal Interactions and the Peierls-Nabarro Barrier

    Science.gov (United States)

    Jenkinson, M.; Weinstein, M. I.

    2017-04-01

    We study a class of discrete focusing nonlinear Schrödinger equations (DNLS) with general nonlocal interactions. We prove the existence of onsite and offsite discrete solitary waves, which bifurcate from the trivial solution at the endpoint frequency of the continuous spectrum of linear dispersive waves. We also prove exponential smallness, in the frequency-distance to the bifurcation point, of the Peierls-Nabarro energy barrier (PNB), as measured by the difference in Hamiltonian or mass functionals evaluated on the onsite and offsite states. These results extend those of the authors for the case of nearest neighbor interactions to a large class of nonlocal short-range and long-range interactions. The appearance of distinct onsite and offsite states is a consequence of the breaking of continuous spatial translation invariance. The PNB plays a role in the dynamics of energy transport in such nonlinear Hamiltonian lattice systems. Our class of nonlocal interactions is defined in terms of coupling coefficients, J m , where {min{Z}} is the lattice site index, with {J_m˜eq m^{-1-2s}, sin[1,∞)} and {J_m˜ e^{-γ|m|}, s=∞, γ > 0,} (Kac-Baker). For {s≥1}, the bifurcation is seeded by solutions of the (effective/homogenized) cubic focusing nonlinear Schrödinger equation (NLS). However, for {1/4 equation, FNLS, with {(-Δ)^s} replacing {-Δ}. The proof is based on a Lyapunov-Schmidt reduction strategy applied to a momentum space formulation. The PN barrier bounds require appropriate uniform decay estimates for the discrete Fourier transform of DNLS discrete solitary waves. A key role is also played by non-degeneracy of the ground state of FNLS, recently proved by Frank, Lenzmann and Silvestrie.

  14. Feasibility study of a single-element transcranial focused ultrasound system for blood-brain barrier opening

    Science.gov (United States)

    Marquet, Fabrice; Tung, Yao-Sheng; Teichert, Tobias; Ferrera, Vincent P.; Konofagou, Elisa E.

    2012-10-01

    The blood-brain barrier (BBB) is a specialized vascular system that impedes entry of all large and the vast majority of small molecules including the most potent CNS disease therapeutic agents from entering from the lumen into the brain parenchyma. Microbubble-enhanced, focused ultrasound (ME-FUS) has been previously shown to disrupt noninvasively, selectively, and transiently the BBB in small animals in vivo. The study addresses the focusing properties of single-element transducers at intermediate frequencies (500 kHz) through primate and human skulls, targeting clinically relevant targets extracted from 3D brain atlases such as the hippocampus and the basal ganglia, which are typically affected by early Alzheimer's and Parkinson's disease, respectively. A preliminary in vivo study was performed to study the frequency dependence of BBB opening parameters in mice. Then, feasibility of transcranial ME-FUS BBB opening in non-human primates was demonstrated with subsequent BBB recovery. Sonications were combined with two different types of microbubbles (custom made 4-5 μm and Definity®). 3T MRI was used to confirm the BBB disruption and to assess brain damage.

  15. A Rule-Based Industrial Boiler Selection System

    Science.gov (United States)

    Tan, C. F.; Khalil, S. N.; Karjanto, J.; Tee, B. T.; Wahidin, L. S.; Chen, W.; Rauterberg, G. W. M.; Sivarao, S.; Lim, T. L.

    2015-09-01

    Boiler is a device used for generating the steam for power generation, process use or heating, and hot water for heating purposes. Steam boiler consists of the containing vessel and convection heating surfaces only, whereas a steam generator covers the whole unit, encompassing water wall tubes, super heaters, air heaters and economizers. The selection of the boiler is very important to the industry for conducting the operation system successfully. The selection criteria are based on rule based expert system and multi-criteria weighted average method. The developed system consists of Knowledge Acquisition Module, Boiler Selection Module, User Interface Module and Help Module. The system capable of selecting the suitable boiler based on criteria weighted. The main benefits from using the system is to reduce the complexity in the decision making for selecting the most appropriate boiler to palm oil process plant.

  16. Pathways and hydrography in the Mesoamerican Barrier Reef System Part 2: Water masses and thermohaline structure

    Science.gov (United States)

    Carrillo, L.; Johns, E. M.; Smith, R. H.; Lamkin, J. T.; Largier, J. L.

    2016-06-01

    Hydrographic data from two oceanographic cruises conducted during March 2006 and January/February 2007 are used to investigate the thermohaline structure related to the observed circulation along the Mesoamerican Barrier Reef System (MBRS). From our observations we identify three water masses in the MBRS: the Caribbean Surface Water (CSW), North Atlantic Subtropical Underwater (SUW), and Tropical Atlantic Central Water (TACW). Little vertical structure in temperature is observed in the upper 100 m of the water column, but important differences are observed in the salinity distribution both horizontally and with depth. Freshwater inputs to the system from the mainland can be traced in the surface layer, with two possible sources: one from surface rivers located along the southern portion of the MBRS, and the other originating from an underground river system located along the northern portion of the MBRS. The thermohaline structure in the MBRS reflects the dynamics of the observed circulation. Uplifted isopycnals along most of the central and northern coastline of the MBRS reflect the effects of the strong geostrophic circulation flowing northward, i.e. the Yucatan Current. To the south along the MBRS, much weaker velocities are observed, with the Honduras Gyre dominating the flow in this region as presented during January/February 2007. These two regions are separated by onshore and divergent alongshore flow associated with the impingement of the Cayman Current on the shore and the MBRS.

  17. A method for risk analysis across governance systems: a Great Barrier Reef case study

    Science.gov (United States)

    Dale, Allan; Vella, Karen; Pressey, Robert L.; Brodie, Jon; Yorkston, Hugh; Potts, Ruth

    2013-03-01

    Healthy governance systems are key to delivering sound environmental management outcomes from global to local scales. There are, however, surprisingly few risk assessment methods that can pinpoint those domains and sub-domains within governance systems that are most likely to influence good environmental outcomes at any particular scale, or those if absent or dysfunctional, most likely to prevent effective environmental management. This paper proposes a new risk assessment method for analysing governance systems. This method is then tested through its preliminary application to a significant real-world context: governance as it relates to the health of Australia’s Great Barrier Reef (GBR). The GBR exists at a supra-regional scale along most of the north eastern coast of Australia. Brodie et al (2012 Mar. Pollut. Bull. 65 81-100) have recently reviewed the state and trend of the health of the GBR, finding that overall trends remain of significant concern. At the same time, official international concern over the governance of the reef has recently been signalled globally by the International Union for the Conservation of Nature (IUCN). These environmental and political contexts make the GBR an ideal candidate for use in testing and reviewing the application of improved tools for governance risk assessment.

  18. Examining Barriers to Internationalisation Created by Diverse Systems and Structures in Vocational Education and Training

    Directory of Open Access Journals (Sweden)

    Angela Joy Shaw

    2016-08-01

    Full Text Available In a global society, all educational sectors need to recognise internationalism as a core, foundational principle. Whilst most educational sectors are taking up that challenge, vocational education and training (VET is still being pulled towards the national agenda in terms of its structures and systems, and the policies driving it, disadvantaging those who graduate from VET, those who teach in it, and the businesses and countries that connect with it. This paper poses questions about the future of internationalisation in the sector. It examines whether there is a way to create a VET system that meets its primary point of value, to produce skilled workers for the local labour market, while still benefitting those graduates by providing international skills and knowledge, gained from VET institutions that are international in their outlook. The paper examines some of the key barriers created by systems and structures in VET to internationalisation and suggests that the efforts which have been made to address the problem have had limited success. It suggests that only a model which gives freedom to those with a direct vested interest, students, teachers, trainers and employers, to pursue international co-operation and liaison will have the opportunity to succeed.

  19. Residual stress analysis of the thermal barrier coating system by considering the plasma spraying process

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Myung Jae; Lee, Byung Chai [KAIST, Daejeon (Korea, Republic of); Lim, Jang Gyun; Kim, Moon Ki [Sungkyunkwan University, Suwon (Korea, Republic of)

    2014-06-15

    The residual stress is the key factor causing the reliability problem of thermal barrier coating (TBC). The failure of plasma spray coatings due to residual stresses is a serious and recurring problem of TBC. The difference of thermal expansion coefficient between the substrate and each coating combined with temperature evolution and temperature gradients during deposition process determine the residual stress for the whole TBC system. The magnitudes and distributions of the residual stresses are affected by deposition process and deposition characteristics. Most of FEA (finite element analysis) has been performed under the assumption that the multilayer coating system is stacked at once without considering the deposition process during plasma spraying. In this research, FEA for a coupled heat transfer and elastic-plastic thermal stress was performed to obtain the more detailed and reliable result of residual stress of the TBC system using the element activation/deactivation technique. The residual stress variation from the start of plasma spraying to cooling stage with room temperature was obtained systematically considering the deposition process. It can be used as reference data to improve the performance of TBC. In addition, the relationship between residual stress and coating conditions such as cooling rate and time is also examined thoroughly.

  20. Planar dynamical systems selected classical problems

    CERN Document Server

    Liu, Yirong; Huang, Wentao

    2014-01-01

    This book presents in an elementary way the recent significant developments in the qualitative theory of planar dynamical systems. The subjects are covered as follows: the studies of center and isochronous center problems, multiple Hopf bifurcations and local and global bifurcations of the equivariant planar vector fields which concern with Hilbert's 16th problem. This book is intended for graduate students, post-doctors and researchers in the area of theories and applications of dynamical systems. For all engineers who are interested the theory of dynamical systems, it is also a reasona

  1. ATTENTIONAL NETWORKS AND SELECTIVE VISUAL SYSTEM

    Directory of Open Access Journals (Sweden)

    ALEJANDRO CASTILLO MORENO

    2006-05-01

    Full Text Available In this paper we checked the principal researches and theories to explain the attention system functioning.We are going to start reviewing along time about the concept of attention, from filter theories andresources distributor theories, to the current theories in which attention is conceived as a control system.From this last point of view, we will emphasize on the attentional networks theory of Posner, thatproposes different systems to explain diverse aspects of attention, but they are related to each other. Atlast in this paper, we will mention experimental results that have been important to characterize theselective attentional mechanisms of the human visual system, using the attentional spotlight model forthis aim.

  2. Motivators, Barriers and Concerns in Adoption of Electronic Filing System: Survey Evidence from Malaysian Professional Accountants

    Directory of Open Access Journals (Sweden)

    Ming-Ling Lai

    2010-01-01

    Full Text Available Problem statement: Worldwide, electronic filing (e-filing system and its' adoption has attracted much attention, however, scholarly study on accounting professionals' acceptance of e-filing system is scant. Approach: This study aimed (i to examine factors that motivated professional accountants to use e-filing (ii to solicit their usage experience and (iii to assess the barriers to adoption and other compliance considerations. The questionnaire survey was administered on 700 professionals from tax practice and commercial sectors who attended "Budget 2008" Tax Seminars, organized by the Malaysian Institute of Accountants in Peninsular Malaysia. In total, 456 usable responses from accounting and tax professionals were collected and analyzed. Results: The survey found out of 456 respondents, just 23.7% had used e-filing in 2007 to file personal tax return forms. Majority of the e-filers opted to use e-filing for the sake of convenience (55.8%, in faith to get faster tax refund (16.8% and speed of filing (15.9%. For those who did not use e-filing, the key impediments were concerned over the security and did not trust of e-filing system. Some (4.8% were unable to access to the e-filing website. Overall, just 26.1% of the professionals surveyed had confidence in the IRBM in managing the e-filing system successfully. Majority (41.2% thought that 'speedy tax refund' to be the most desirable incentive to motivate individuals to use e-filing. Conclusion: As the IRBM is counting on professional accountants to promote the usage of e-filing system, this study provided important insights to the IRBM to developing marketing and business strategies to motivate professional accountant in business to use e-filing in order to accelerate the diffusion of e-filing system in a developing country like Malaysia.

  3. Difference Antenna Selection and Power Allocation for Wireless Cognitive Systems

    CERN Document Server

    Wang, Yue

    2010-01-01

    In this paper, we propose an antenna selection method in a wireless cognitive radio (CR) system, namely difference selection, whereby a single transmit antenna is selected at the secondary transmitter out of $M$ possible antennas such that the weighted difference between the channel gains of the data link and the interference link is maximized. We analyze mutual information and outage probability of the secondary transmission in a CR system with difference antenna selection, and propose a method of optimizing these performance metrics of the secondary data link subject to practical constraints on the peak secondary transmit power and the average interference power as seen by the primary receiver. The optimization is performed over two parameters: the peak secondary transmit power and the difference selection weight $\\delta\\in [0, 1]$. We show that, difference selection using the optimized parameters determined by the proposed method can be, in many cases of interest, superior to a so called ratio selection me...

  4. Barriers to Health Promotion and Disease Prevention Within the Military Healthcare System

    Science.gov (United States)

    2013-01-31

    1997). Barriers encountered in osteoporosis prevention are related to the fear that estrogen therapy is harmful (Salamone, Barriers to Health...immunization, mammography, cervical Papanicolaou smear, and physical examination (Dutton, 1986; Elnicki, Morris, & Shockcor, 1995). Provider-Consumer...waiting times at appointments, lack of evening and weekend appointments, inadequate physical space, and inadequate facilities for child care also

  5. The socio-technical barriers to Solar Home Systems (SHS) in Papua New Guinea: 'Choosing pigs, prostitutes, and poker chips over panels'

    Energy Technology Data Exchange (ETDEWEB)

    Sovacool, Benjamin K., E-mail: bsovacool@nus.edu.s [Lee Kuan Yew School of Public Policy, National University of Singapore, 469C Bukit Timah Road, Singapore 259772 (Singapore); D' Agostino, Anthony L.; Jain Bambawale, Malavika [Lee Kuan Yew School of Public Policy, National University of Singapore, 469C Bukit Timah Road, Singapore 259772 (Singapore)

    2011-03-15

    This study explores the socio-technical barriers to Solar Home Systems (SHS) in Papua New Guinea. The authors collected primary data through semi-structured research interviews conducted over the course of February 2010-April 2010. Respondents included government officials, financiers, planners, commercial distributors and companies, teachers and rural villagers in addition to members of civil society, academics, consultants, and trainers. These interviews were supplemented with site visits to Port Moresby, Goroka, and Madang, and field research in the villages of Akameku, Asaroka, Lufa, Kundiawa, Okifa, Simbu, and Talidig. The study draws from these interviews and visits to discuss four types of barriers. Technical barriers relate to substandard equipment and logistical problems. Economic barriers include high rates of poverty, misconceptions about the role of currency, and lack of financing. Political barriers include poor institutional capacity and a government commitment to fossil-fueled grid electrification. Social barriers encompass unrealistic expectations about what SHS can provide along with jealousy, theft, vandalism, and unfamiliarity with solar technology. - Research highlights: {yields} Solar Home Systems (SHS) are impeded by a collection of different barriers in Papua New Guinea. {yields} Technical barriers relate to substandard equipment and logistical problems. {yields} Economic barriers include high rates of poverty, misconceptions about the role of currency, and lack of financing.{yields} Political barriers include poor institutional capacity and a government commitment to fossil-fueled grid electrification. {yields} Social barriers encompass unrealistic expectations about what SHS can provide along with jealousy, theft, vandalism, and unfamiliarity with solar technology.

  6. Wheelchair users’ perspectives on barriers in public spaces in Vienna: implications for the development of a barrier information system / Barrieren aus der Sicht von Rollstuhlnutzern/-innen im öffentlichen Raum in Wien: Implikationen für ein Barriere-Informationssystem

    Directory of Open Access Journals (Sweden)

    Außermaier Hannes

    2016-12-01

    Full Text Available Wheelchair users often encounter barriers reducing community mobility and participation in societal life. Information on barrier-free routes may improve mobility and therefore societal participation. In addition to technical prerequisites, a routing system will only be effective and used by the target group, if the development process is based on their perceptions and needs. The aim of the study was therefore to collect data on barriers from the viewpoint of wheelchair users in Vienna.

  7. Task Analyses of Three Selected Weapons Systems.

    Science.gov (United States)

    1976-10-01

    using weapons is a joint function of the specific weapon system, the goals (missions) of the system, and the environment in which it is used. The first...Identification of fire mission profiles which state general job functions for each type of typical mission. Documentary sources such as Field Manuals...nd Arin,,, Ui, Guni i A,!i" tant uuPnrr No. I Can; n , r Grup - ( nile. .rs and Prir Diff,-ront S, tm: -inch L,,t.’r _, Fort Hood l::t Cavall, I

  8. AVNG SYSTEM SOFTWARE - ATTRIBUTE VERIFICATION SYSTEM WITH INFORMATION BARRIERS FOR MASS AND ISOTOPICS MEASUREMENTS

    Energy Technology Data Exchange (ETDEWEB)

    Modenov, A; Bulatov, M; Livke, A; Morkin, A; Razinkov, S; Safronov, S; Elmont, T; Langner, D; MacArthur, D; Mayo, D; Smith, M; Luke, S J

    2005-06-10

    This report describes the software development for the plutonium attribute verification system--AVNG. A brief synopsis of the technical solution for the measurement system is presented. The main tasks for the software development that is underway are formulated. The development tasks are shown in software structural flowcharts, measurement system state diagram and a description of the software. The current status of the AVNG software development is elucidated.

  9. Considerations for IC and Component Selection for Space Systems

    Science.gov (United States)

    LaBel, Kenneth A.; Cohn, Lewis M.

    2008-01-01

    This viewgraph presentation addresses the integrated cycling and component selection technologies for aerospace systems. The topics include: 1) Semiconductors: The Evolution of ICs - Availability and Technology; 2) IC Selection Requirements - three fields of thought, "The Good", "The Bad" and "The Ugly"; 3) Reliability and Radiation; 4) Radiation Perspective-Four methods of selecting ICs for space systems, Guaranteed hardness, historical ground-based radiation data, historical flight usage, and unknown assurance; 5) Understanding Risk, including risk trade space and ASICs and FPGA sample selection criteria.

  10. Study of nuclear structure effect on fusion through barrier distribution for the system 28Si+154Sm

    Directory of Open Access Journals (Sweden)

    Kaur Gurpreet

    2015-01-01

    Full Text Available We plan to perform large angle quasi-elastic scattering experiments using a 28Si beam on heavy targets in order to study the nuclear dynamics and structure effects. As a prelude to our first test experiment with a 154Sm target, we study here the existing fusion data for the same system through the barrier distribution.

  11. Review of underground logistic systems in the Netherlands: an ex-post evaluation of barriers, enablers and spin-offs

    NARCIS (Netherlands)

    Wiegmans, B.W.; Visser, J.; Konings, R.; Pielage, B.J.A.

    2010-01-01

    Now, 10 years after the first plans, we analyse in this paper what has happened with Underground Logistic Systems (ULS). The major question in this paper is: Which barriers and enablers led to the failure of ULS and what ULS spin-offs can be found nowadays? Several factors can be classified as barri

  12. Optimalization of selected RFID systems Parameters

    Directory of Open Access Journals (Sweden)

    Peter Vestenicky

    2004-01-01

    Full Text Available This paper describes procedure for maximization of RFID transponder read range. This is done by optimalization of magnetics field intensity at transponder place and by optimalization of antenna and transponder coils coupling factor. Results of this paper can be used for RFID with inductive loop, i.e. system working in near electromagnetic field.

  13. A Simple Selection System Called "Jobmatch."

    Science.gov (United States)

    Sheibar, Paul

    1979-01-01

    An automated candidate-job matching system called "Jobmatch" has been implemented at Citibank, in New York City, involving job analysis, performance appraisal techniques, clerical employment, and internal mobility. A job task scale is used by supervisor and employee to determine job and candidate matching through a series of computer…

  14. Solving problems in social-ecological systems: definition, practice and barriers of transdisciplinary research.

    Science.gov (United States)

    Angelstam, Per; Andersson, Kjell; Annerstedt, Matilda; Axelsson, Robert; Elbakidze, Marine; Garrido, Pablo; Grahn, Patrik; Jönsson, K Ingemar; Pedersen, Simen; Schlyter, Peter; Skärbäck, Erik; Smith, Mike; Stjernquist, Ingrid

    2013-03-01

    Translating policies about sustainable development as a social process and sustainability outcomes into the real world of social-ecological systems involves several challenges. Hence, research policies advocate improved innovative problem-solving capacity. One approach is transdisciplinary research that integrates research disciplines, as well as researchers and practitioners. Drawing upon 14 experiences of problem-solving, we used group modeling to map perceived barriers and bridges for researchers' and practitioners' joint knowledge production and learning towards transdisciplinary research. The analysis indicated that the transdisciplinary research process is influenced by (1) the amount of traditional disciplinary formal and informal control, (2) adaptation of project applications to fill the transdisciplinary research agenda, (3) stakeholder participation, and (4) functional team building/development based on self-reflection and experienced leadership. Focusing on implementation of green infrastructure policy as a common denominator for the delivery of ecosystem services and human well-being, we discuss how to diagnose social-ecological systems, and use knowledge production and collaborative learning as treatments.

  15. Spatiotemporal variability of sedimentology and morphology in the East Frisian barrier island system

    Science.gov (United States)

    Herrling, Gerald; Winter, Christian

    2016-08-01

    The highly dynamic East Frisian barrier island system (southern North Sea) is characterized by a complex morphology of tidal inlets, ebb-tidal deltas and foreshore beaches that reacts to storms and fair-weather conditions with characteristic patterns of sediment grain-size distributions. The morphological and sedimentological response to varying hydrodynamic conditions yet occurs in short time spans that are not covered by common monitoring strategies with measuring intervals typically of years. This study applies process-based numerical modelling with multiple sediment fractions to interpolate morphological states in time between bathymetrical surveys conducted in the summer months of 2004 and 2006. Morphodynamic simulations driven by real-time boundary conditions of tides, wind and waves are carried out for a representative period of 2 years. The spatiotemporal variability of the nearshore sedimentology and morphology is assessed by graded ranges of bed dynamics (i.e. bed elevation range) and the definition of sediment grain-size variability (i.e. mean diameter range). The effect of storm events and timescales of the sedimentological adaptation after storms to typical fair-weather conditions are exemplified at an ebb-tidal delta lobe where the morphological and sedimentological variability is found to be largest in the study area. The proposed method may serve to identify areas of high sedimentological and morphological activity for system understanding or in the framework of coastal monitoring strategies.

  16. Assessing blood brain barrier dynamics or identifying or measuring selected substances, including ethanol or toxins, in a subject by analyzing Raman spectrum signals

    Science.gov (United States)

    Lambert, James L. (Inventor); Borchert, Mark S. (Inventor)

    2008-01-01

    A non-invasive method for analyzing the blood-brain barrier includes obtaining a Raman spectrum of a selected portion of the eye and monitoring the Raman spectrum to ascertain a change to the dynamics of the blood brain barrier.Also, non-invasive methods for determining the brain or blood level of an analyte of interest, such as glucose, drugs, alcohol, poisons, and the like, comprises: generating an excitation laser beam at a selected wavelength (e.g., at a wavelength of about 400 to 900 nanometers); focusing the excitation laser beam into the anterior chamber of an eye of the subject so that aqueous humor, vitreous humor, or one or more conjunctiva vessels in the eye is illuminated; detecting (preferably confocally detecting) a Raman spectrum from the illuminated portion of the eye; and then determining the blood level or brain level (intracranial or cerebral spinal fluid level) of an analyte of interest for the subject from the Raman spectrum. In certain embodiments, the detecting step may be followed by the step of subtracting a confounding fluorescence spectrum from the Raman spectrum to produce a difference spectrum; and determining the blood level and/or brain level of the analyte of interest for the subject from that difference spectrum, preferably using linear or nonlinear multivariate analysis such as partial least squares analysis. Apparatus for carrying out the foregoing methods are also disclosed.

  17. Novel targeted approach to better understand how natural structural barriers govern carotenoid in vitro bioaccessibility in vegetable-based systems.

    Science.gov (United States)

    Palmero, Paola; Lemmens, Lien; Ribas-Agustí, Albert; Sosa, Carola; Met, Kristof; de Dieu Umutoni, Jean; Hendrickx, Marc; Van Loey, Ann

    2013-12-01

    An experimental approach, allowing us to understand the effect of natural structural barriers (cell walls, chromoplast substructures) on carotenoid bioaccessibility, was developed. Different fractions with different levels of carotenoid bio-encapsulation (carotenoid-enriched oil, chromoplasts, small cell clusters, and large cell clusters) were isolated from different types of carrots and tomatoes. An in vitro method was used to determine carotenoid bioaccessibility. In the present work, a significant decrease in carotenoid in vitro bioaccessibility could be observed with an increasing level of bio-encapsulation. Differences in cell wall material and chromoplast substructure between matrices influenced carotenoid release and inclusion in micelles. For carrots, cell walls and chromoplast substructure were important barriers for carotenoid bioaccessibility while, in tomatoes, the chromoplast substructure represented the most important barrier governing bioaccessibility. The highest increase in carotenoid bioaccessibility, for all matrices, was obtained after transferring carotenoids into the oil phase, a system lacking cell walls and chromoplast substructures that could hamper carotenoid release.

  18. Converse Barrier Certificate Theorems

    DEFF Research Database (Denmark)

    Wisniewski, Rafael; Sloth, Christoffer

    2016-01-01

    This paper shows that a barrier certificate exists for any safe dynamical system. Specifically, we prove converse barrier certificate theorems for a class of structurally stable dynamical systems. Other authors have developed a related result by assuming that the dynamical system has neither sing...

  19. Laser Based Information Systems (Selected Pages),

    Science.gov (United States)

    1986-05-22

    from the object; 10- turning mirror; 11- Cardan " suspension; 12-- servodrive; 13- periscope; 14- system for manual control- 15- dissector; 16...automatic tracing. The controlled mirror is mounted in a cardan suspension the axes of which are driven by dc servomotors. With the axes...gyroscope with the velocity of 100-500 deg/h arises because of the friction in the pivots of the Cardan 120 -" 1 support and imperfect balancing. In

  20. Determining gene flow and the influence of selection across the equatorial barrier of the East Pacific Rise in the tube-dwelling polychaete Alvinella pompejana

    Directory of Open Access Journals (Sweden)

    Plouviez Sophie

    2010-07-01

    a selective sweep or hitch-hiking. Conclusions The equatorial barrier leading to the separation of East Pacific Rise vent fauna into two distinct geographic groups is still permeable to migration, with a probable north-to-south migration route for A. pompejana. This separation also coincides with demographic expansion in the southern East Pacific Rise. Our results suggest that allopatry resulting from ridge offsetting is a common mechanism of speciation for deep-sea hydrothermal vent organisms.

  1. Durability and CMAS Resistance of Advanced Environmental Barrier Coatings Systems for SiC/SiC Ceramic Matrix Composites

    Science.gov (United States)

    Zhu, Dongming

    2015-01-01

    Environmental barrier coatings (EBCs) and SiCSiC ceramic matrix composites (CMCs) systems will play a crucial role in next generation turbine engines for hot-section component applications because of their ability to significantly increase engine operating temperatures with improved efficiency, reduce engine weight and cooling requirements. This paper will emphasize advanced environmental barrier coating developments for SiCSiC turbine airfoil components, by using advanced coating compositions and processing, in conjunction with mechanical and environment testing and durability validations. The coating-CMC degradations and durability in the laboratory simulated engine fatigue-creep and complex operating environments are being addressed. The effects of Calcium-Magnesium-Alumino-Silicate (CMAS) from road sand or volcano-ash deposits on the degradation mechanisms of the environmental barrier coating systems will be discussed. The results help understand the advanced EBC-CMC system performance, aiming at the durability improvements of more robust, prime-reliant environmental barrier coatings for successful applications of the component technologies and lifing methodologies.

  2. Changes in skin barrier during treatment with systemic alitretinoin: focus on skin susceptibility and stratum corneum ceramides.

    Science.gov (United States)

    Jungersted, Jakob Mutanu; Høgh, Julie K; Hellgren, Lars I; Jemec, Gregor B E; Agner, Tove

    2010-11-01

    Alitretinoin is a new drug for systemic treatment of chronic hand eczema. Previous functional tests of skin topically treated with retinoids have indicated impaired skin barrier function, but no data are available on barrier parameters after systemic alitretinoin treatment. To investigate the effect of systemic alitretinoin on skin barrier function and response to irritants, a secondary objective was to determine if changes occur in the lipid profile of stratum corneum after treatment with systemic alitretinoin. We conducted an open clinical intervention study on eight people ascribed to systemic alitretinoin treatment. The criteria for being ascribed to alitretinoin were chronic hand eczema and insufficient therapeutic response to potent topical corticosteroids. Before initiation and after 2 months of systemic treatment with 30 mg alitretinoin, a challenge with sodium lauryl sulphate (SLS) was performed on the volar forearm and evaluated by trans-epidermal water loss (TEWL), erythema, and a cyanoacrylate skin sample was obtained for lipid analysis. We found no significant changes in response to SLS irritation as evaluated by TEWL and erythema, after treatment with alitretinoin for 2 months. No significant changes in stratum corneum lipids were found after 2 months of treatment. In conclusion, systemic alitretinoin does not influence skin susceptibility to irritants or the ceramide profile of stratum corneum.

  3. DETERMINATION OF CREEP PROPERTIES OF THERMAL BARRIER COATING(TBC) SYSTEMS FROM THE INDENTATION CREEP TESTING WITH ROUND FLAT INDENTERS

    Institute of Scientific and Technical Information of China (English)

    B. Zhao; B.X. Xu; J. Liu; Z.F. Yue

    2004-01-01

    Indentation creep behavior with cylindrical flat indenters on the thermal barrier coating (TBC) was studied by finite element method (FEM). On the constant applied indentation creep stress, there is a steady creep rate for each case studied for different creep properties of the TBC system. The steady creep depth rate depends on the applied indentation creep stress and size of the indenters as well as the creep properties of the bond coat of the TBC and the substrate. The possibilities to determine the creep properties of a thermal barrier system from indention creep testing were discussed. As an example, with two different size indenters, the creep properties of bond coat of the TBC system can be derived by an inverse FEM method. This study not only provides a numerical method to obtain the creep properties of the TBC system, but also extends the application of indentation creep method with cylindrical flat indenters.

  4. Drivers and barriers among householders to managing domestic wastewater treatment systems in the Republic of Ireland; implications for risk prevention behaviour

    Science.gov (United States)

    Devitt, Catherine; O'Neill, Eoin; Waldron, Richard

    2016-04-01

    Septic systems that are malfunctioning, improperly sited or designed, present a contamination risk to drinking water sources, and subsequently, to human health. However, the international literature identifies gaps in householder knowledge regarding the function and maintenance requirements of septic systems, and also the potential health and environmental risk implications. Allied with householder fears related to the financial cost of risk management, these factors tend to reduce concern to recognise a malfunctioning system. In the Republic of Ireland, three-quarters of households in rural areas utilise an individual domestic wastewater treatment system (or septic system). Consequently, a significant portion of rural households that rely on groundwater sources via private-well use are at risk. Ireland reports one of the highest crude incidence rates of Verotoxigenic Escherichia coli (VTEC) infection in the European Union, and waterborne transmission related to contact with untreated or poorly treated water from private water sources is a factor in its transmission. Following recent Irish legislative change that places a duty of care on individual householders to ensure a proper system functioning, this exploratory study examines perceptions towards the risk management of septic systems among Irish householders. Using qualitative research methods, four focus groups selected on the basis of geographical variation, and two semi-structured interviews were conducted. While most householders agreed that poorly maintained septic systems represented a threat to the environment and to public health, none reported to having a regular maintenance routine in place. Thematic analysis revealed the drivers and barriers to septic system maintenance, and preferences of householders pertaining to communication on septic systems. The Health Belief Model is employed to help understand results. Results suggest that householder capacity to engage in regular risk management is reduced

  5. Nanowired Drug Delivery Across the Blood-Brain Barrier in Central Nervous System Injury and Repair.

    Science.gov (United States)

    Sharma, Aruna; Menon, Preeti; Muresanu, Dafin F; Ozkizilcik, Asya; Tian, Z Ryan; Lafuente, José V; Sharma, Hari S

    2016-01-01

    The blood-brain barrier (BBB) is a physiological regulator of transport of essential items from blood to brain for the maintenance of homeostasis of the central nervous system (CNS) within narrow limits. The BBB is also responsible for export of harmful or metabolic products from brain to blood to keep the CNS fluid microenvironment healthy. However, noxious insults to the brain caused by trauma, ischemia or environmental/chemical toxins alter the BBB function to small as well as large molecules e.g., proteins. When proteins enter the CNS fluid microenvironment, development of brain edema occurs due to altered osmotic balance between blood and brain. On the other hand, almost all neurodegenerative diseases and traumatic insults to the CNS and subsequent BBB dysfunction lead to edema formation and cell injury. To treat these brain disorders suitable drug therapy reaching their brain targets is needed. However, due to edema formation or only a focal disruption of the BBB e.g., around brain tumors, many drugs are unable to reach their CNS targets in sufficient quantity. This results in poor therapeutic outcome. Thus, new technology such as nanodelivery is needed for drugs to reach their CNS targets and be effective. In this review, use of nanowires as a possible novel tool to enhance drug delivery into the CNS in various disease models is discussed based on our investigations. These data show that nanowired delivery of drugs may have superior neuroprotective ability to treat several CNS diseases effectively indicating their role in future therapeutic strategies.

  6. International Collaborations on Engineered Barrier Systems: Brief Overview of SKB-EBS Activities.

    Energy Technology Data Exchange (ETDEWEB)

    Jove-Colon, Carlos F. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-10-01

    Research collaborations with international partners on the behavior and performance of engineered barrier systems (EBS) are an important aspect of the DOE-NE Used Fuel Disposition Campaign strategy in the evaluation of disposal design concepts. These international partnerships are a cost-effective way of engaging in key R&D activities with common goals resulting in effective scientific knowledge exchanges thus enhancing existing and future research programs in the USA. This report provides a brief description of the activities covered by the Swedish Nuclear Fuel and Waste Management Company (SKB) EBS Task Force (TF) (referred hereafter as SKB EBS TF) and potential future directions for engagement of the DOE-NE UFDC program in relevant R&D activities. Emphasis is given to SKB EBS TF activities that are still ongoing and aligned to the UFDC R&D program. This include utilization of data collected in the bentonite rock interaction experiment (BRIE) and data sets from benchmark experiments produced by the chemistry or “C” part of the SKB EBS TF. Potential applications of information generated by this program include comparisons/tests between model and data (e.g., reactive diffusion), development and implementation of coupled-process models (e.g., HM), and code/model benchmarking.

  7. Numerical study of a simple transcranial focused ultrasound system applied to blood-brain barrier opening.

    Science.gov (United States)

    Deffieux, Thomas; Konofagou, Elisa E

    2010-12-01

    In this paper, we investigate the focalization properties of single-element transducers at low frequencies (300 to 1000 kHz) through primate and human skulls. The study addresses the transcranial targeting involved in ultrasound- induced blood-brain barrier (BBB) opening with clinically relevant targets such as the hippocampus and the basal ganglia, which are typically affected by early Alzheimer's and Parkinson's disease, respectively. A finite-difference, timedomain simulation platform is used to solve the 3-D linear acoustic wave equation with CT-based acoustic maps of the skulls. The targeted brain structures were extracted from 3-D brain atlases registered with the skulls and used to virtually position and orient the transducers. The effect of frequency is first investigated and the targeting of the different structures is then tested. The frequency of 500 kHz provided the best tradeoff between phase aberrations and standing wave effects in the human case, whereas the frequency of 800 kHz was most suitable in the case of the primate skull. A fast periodic linear chirp method was developed and found capable of reducing the standing wave effects. Such a simple, affordable, and convenient system is concluded to be feasible for BBB opening in primates and humans and could thus allow for its broader impact and applications.

  8. The density-driven circulation of the coastal hypersaline system of the Great Barrier Reef, Australia.

    Science.gov (United States)

    Salamena, Gerry G; Martins, Flávio; Ridd, Peter V

    2016-04-15

    The coastal hypersaline system of the Great Barrier Reef (GBR) in the dry season, was investigated for the first time using a 3D baroclinic model. In the shallow coastal embayments, salinity increases to c.a. 1‰ above typical offshore salinity (~35.4‰). This salinity increase is due to high evaporation rates and negligible freshwater input. The hypersalinity drifts longshore north-westward due to south-easterly trade winds and may eventually pass capes or headlands, e.g. Cape Cleveland, where the water is considerably deeper (c.a. 15m). Here, a pronounced thermohaline circulation is predicted to occur which flushes the hypersalinity offshore at velocities of up to 0.08m/s. Flushing time of the coastal embayments is around 2-3weeks. During the dry season early summer, the thermohaline circulation reduces and therefore, flushing times are predicted to be slight longer due to the reduced onshore-offshore density gradient compared to that in the dry season winter period.

  9. Addressing health system barriers to access to and use of skilled delivery services: perspectives from Ghana.

    Science.gov (United States)

    Ganle, John Kuumuori; Fitzpatrick, Raymond; Otupiri, Easmon; Parker, Michael

    2016-10-01

    Poor access to and use of skilled delivery services have been identified as a major contributory factor to poor maternal and newborn health in sub-Saharan African countries, including Ghana. However, many previous studies that examine norms of childbirth and care-seeking behaviours have focused on identifying the norms of non-use of services, rather than factors, that can promote service use. Based on primary qualitative research with a total of 185 expectant and lactating mothers, and 20 healthcare providers in six communities in Ghana, this paper reports on strategies that can be used to overcome health system barriers to the use of skilled delivery services. The strategies identified include expansion and redistribution of existing maternal health resources and infrastructure, training of more skilled maternity caregivers, instituting special programmes to target women most in need, improving the quality of maternity care services provided, improving doctor-patient relationships in maternity wards, promotion of choice, protecting privacy and patient dignity in maternity wards and building partnerships with traditional birth attendants and other non-state actors. The findings suggest the need for structural changes to maternity clinics and routine nursing practices, including an emphasis on those doctor-patient relational practices that positively influence women's healthcare-seeking behaviours. Copyright © 2015 John Wiley & Sons, Ltd.

  10. Mini-med school for Aboriginal youth: experiential science outreach to tackle systemic barriers

    Directory of Open Access Journals (Sweden)

    Rita I. Henderson

    2015-12-01

    Full Text Available Introduction: Addressing systemic barriers experienced by low-income and minority students to accessing medical school, the University of Calgary's Cumming School of Medicine has spearheaded a year-round, mini-med school outreach initiative for Aboriginal students. Method: Junior and senior high school youth generally attend the half-day program in classes or camps of 15–25, breaking into small groups for multisession activities. Undergraduate medical education students mentor the youth in stations offering experiential lessons in physical examination, reading x-rays, and anatomy. All resources from the medical school are offered in-kind, including a pizza lunch at midday, whereas community partners organize transportation for the attendees. Results: Opening the medical school and its resources to the community offers great benefits to resource-constrained schools often limited in terms of science education resources. The model is also an effort to address challenges among the medical professions around attracting and retaining students from underserved populations. Conclusion: The prospect of increasing admission rates and successful completion of medical education among students from marginalized communities poses a real, though difficult-to-measure, possibility of increasing the workforce most likely to return to and work in such challenging contexts. A mini-medical school for Aboriginal youth highlights mutual, long-term benefit for diverse partners, encouraging medical educators and community-based science educators to explore the possibilities for deepening partnerships in their own regions.

  11. Simulation of residual stresses and their effects on thermal barrier coating systems using finite element method

    Science.gov (United States)

    Zhu, JianGuo; Chen, Wei; Xie, HuiMin

    2015-03-01

    Thermal barrier coating (TBC) systems are widely used in industrial gas-turbine engines. However, premature failures have impaired the use of TBCs and cut down their lifetime, which requires a better understanding of their failure mechanisms. In the present study, experimental studies of isothermal cycling are firstly carried out with the observation and estimation of microstructures. According to the experimental results, a finite element model is established for the analysis of stress perpendicular to the TBC/BC interface. Detailed residual stress distributions in TBC are obtained to reflect the influence of mechanical properties, oxidation, and interfacial roughness. The calculated results show that the maximum tensile stress concentration appears at the peak of TBC and continues to increase with thermal cycles. Because of the microstructural characteristics of plasma-sprayed TBCs, cracks initialize in tensile stress concentration (TSC) regions at the peaks of TBC and propagate along the TBC/BC interface resulting in the spallation of TBC. Also, the inclusion of creep is crucial to failure prediction and is more important than the inclusion of sintering in the simulation.

  12. A Study of Expert System for Career Selection: Literature Review

    Directory of Open Access Journals (Sweden)

    Waghmode M. L

    2015-09-01

    Full Text Available Expert system uses human knowledge stored inside a computer to solve problems those require human expertise for solving. Knowledge expert system helps to support for making better decision. There is need of career guidance for students at college level. Expert system plays an important role to facilitate decision making, diagnosis of diseases etc. Expert system for career selection can be developed using Fuzzy logic, neural network for guiding students for selecting proper career stream. From the literature review it has found that in Maharashtra comparatively very less research took place on expert system for career selection. Hence there is wide scope in expert system development for career guidance which will assist secondary and higher secondary students in Maharashtra for selecting proper career. Through this paper researcher thrown light on literature review of career selection expert systems. Here for career selection researcher reviewed 43 literatures including 2-conference proceeding, 8-Books, 22- Journals, 1-Report, 5-Thesis, 3-Websites, 2-Encyclopaedia articles and 2-generic articles. Articles referred are from last two decades and majority of them are latest.

  13. Improving energy efficiency in industrial energy systems an interdisciplinary perspective on barriers, energy audits, energy management, policies, and programs

    CERN Document Server

    Thollander, Patrik

    2012-01-01

    Industrial energy efficiency is one of the most important means of reducing the threat of increased global warming. Research however states that despite the existence of numerous technical energy efficiency measures, its deployment is hindered by the existence of various barriers to energy efficiency. The complexity of increasing energy efficiency in manufacturing industry calls for an interdisciplinary approach to the issue. Improving energy efficiency in industrial energy systems applies an interdisciplinary perspective in examining energy efficiency in industrial energy systems, and discuss

  14. Sequence Selection and Performance in DS/CDMA Systems

    Directory of Open Access Journals (Sweden)

    Jefferson Santos Ambrosio

    2016-03-01

    Full Text Available In this work key concepts on coding division multiple access (CDMA communication systems have been discussed. The sequence selection impact on the performance and capacity of direct sequence CDMA (DS/CDMA systems under AWGN and increasing system loading, as well as under multiple antennas channels was investigated.

  15. The Selection of Cooling Systems of Giant Hydro-Generators

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The selection of cooling system for hydro-generator in Ertan Hydropower Station is reviewed in this paper. The new viewpoint on air-cooled system of hydraulic generator of recent years is analyzed and described. That is, "Full air-cooled system is always preferred to inner

  16. Development of a Selectable Output Ultraviolet Laser System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Here, we propose to develop a breadboard laser system that is capable of producing radiation in two UV wavelengths.  This Selectable Output Ultraviolet Laser...

  17. Political, policy and social barriers to health system interoperability: emerging opportunities of Web 2.0 and 3.0.

    Science.gov (United States)

    Juzwishin, Donald W M

    2009-01-01

    Achieving effective health informatics interoperability in a fragmented and uncoordinated health system is by definition not possible. Interoperability requires the simultaneous integration of health care processes and information across different types and levels of care (systems thinking). The fundamental argument of this paper is that information system interoperability will remain an unfulfilled hope until health reforms effectively address the governance (accountability), structural and process barriers to interoperability of health care delivery. The ascendency of Web 2.0 and 3.0, although still unproven, signals the opportunity to accelerate patients' access to health information and their health record. Policy suggestions for simultaneously advancing health system delivery and information system interoperability are posited.

  18. Selected topics on extrasolar planetary systems

    Science.gov (United States)

    Ford, Eric B.

    This thesis investigates the capabilities of planet searches to detect extrasolar planets and measure their mass and orbital parameters. I developed and demonstrated a new technique based on Markov chain Monte Carlo simulations to quantify the uncertainty in the orbital parameters of extrasolar planets using actual radial velocity observations. It is hoped that future astrometric searches will build upon the successes of radial velocity searches, providing new information about currently known planets and discovering new ones. In particular, the Space Interferometry Mission (SIM) will be capable of detecting low-mass planets around nearby stars. I simulated astrometric observations to evaluate the planet-finding capabilities of SIM and estimate the number of planets which SIM planet searches would detect and characterize and explore how various factors would affect SIM's sensitivity. For example, I investigated the tradeoffs between observing more stars at lower precision and observing less stars at higher precision. I also determined that the choice of observing schedule has relatively little effect on SIM's efficiency, so it is likely best to schedule observations so as to minimize overhead (e.g., slewing, measuring grid stars). Similarly, I quantified how much SIM's efficiency is reduced when a target star has an acceleration due to a wide-binary companion, concluding that it is generally preferable to target a nearby star in a wide-binary system rather than a more distant single star. Finally, I explored how the presence of two planets around a star can make it more difficult for SIM to measure the masses and orbital parameters of either planet. I find that the presence a giant planet can significantly reduce the sensitivity of SIM for measuring the low-mass mass and orbital parameters of a low-mass planet. Each of these studies will help guide decisions, so that SIM's valuable observing time can be used most productively.

  19. Interactions between barrier islands and backbarrier marshes affect island system response to sea level rise: Insights from a coupled model

    Science.gov (United States)

    Walters, David; Moore, Laura J.; Duran Vinent, Orencio; Fagherazzi, Sergio; Mariotti, Giulio

    2014-09-01

    Interactions between backbarrier marshes and barrier islands will likely play an important role in determining how low-lying coastal systems respond to sea level rise and changes in storminess in the future. To assess the role of couplings between marshes and barrier islands under changing conditions, we develop and apply a coupled barrier island-marsh model (GEOMBEST+) to assess the impact of overwash deposition on backbarrier marsh morphology and of marsh morphology on rates of island migration. Our model results suggest that backbarrier marsh width is in a constant state of change until either the backbarrier basin becomes completely filled or backbarrier marsh deposits have completely eroded away. Results also suggest that overwash deposition is an important source of sediment, which allows existing narrow marshes to be maintained in a long-lasting alternate state (~500 m wide in the Virginia Barrier Islands) within a range of conditions under which they would otherwise disappear. The existence of a narrow marsh state is supported by observations of backbarrier marshes along the eastern shore of Virginia. Additional results suggest that marshes reduce accommodation in the backbarrier bay, which, in turn, decreases island migration rate. As climate change results in sea level rise, and the increased potential for intense hurricanes resulting in overwash, it is likely that these couplings will become increasingly important in determining future system behavior.

  20. Managing Selection for Electronic Resources: Kent State University Develops a New System to Automate Selection

    Science.gov (United States)

    Downey, Kay

    2012-01-01

    Kent State University has developed a centralized system that manages the communication and work related to the review and selection of commercially available electronic resources. It is an automated system that tracks the review process, provides selectors with price and trial information, and compiles reviewers' feedback about the resource. It…

  1. Attitude towards the incorporation of the selective collection of biowaste in a municipal solid waste management system. A case study.

    Science.gov (United States)

    Bernad-Beltrán, D; Simó, A; Bovea, M D

    2014-12-01

    European waste legislation has been encouraging for years the incorporation of selective collection systems for the biowaste fraction. European countries are therefore incorporating it into their current municipal solid waste management (MSWM) systems. However, this incorporation involves changes in the current waste management habits of households. In this paper, the attitude of the public towards the incorporation of selective collection of biowaste into an existing MSWM system in a Spanish municipality is analysed. A semi-structured telephone interview was used to obtain information regarding aspects such as: level of participation in current waste collection systems, willingness to participate in selective collection of biowaste, reasons and barriers that affect participation, willingness to pay for the incorporation of the selective collection of biowaste and the socioeconomic characteristics of citizens who are willing to participate and pay for selective collection of biowaste. The results showed that approximately 81% of the respondents were willing to participate in selective collection of biowaste. This percentage would increase until 89% if the Town Council provided specific waste bins and bags, since the main barrier to participate in the new selective collection system is the need to use specific waste bin and bags for the separation of biowaste. A logit response model was applied to estimate the average willingness to pay, obtaining an estimated mean of 7.5% on top of the current waste management annual tax. The relationship of willingness to participate and willingness to pay for the implementation of this new selective collection with the socioeconomic variables (age, gender, size of the household, work, education and income) was analysed. Chi-square independence tests and binary logistic regression was used for willingness to participate, not being obtained any significant relationship. Chi-square independence tests, ordinal logistic regression and

  2. Perceived barriers of heart failure nurses and cardiologists in using clinical decision support systems in the treatment of heart failure patients

    OpenAIRE

    Vries, Arjen E. de; van der Wal, Martje H. L.; Nieuwenhuis, Maurice M. W.; Richard M. de Jong; Rene B. van Dijk; Jaarsma, Tiny; Hillege, Hans L; Jorna, Rene J.

    2013-01-01

    Background Clinical Decision Support Systems (CDSSs) can support guideline adherence in heart failure (HF) patients. However, the use of CDSSs is limited and barriers in working with CDSSs have been described as a major obstacle. It is unknown if barriers to CDSSs are present and differ between HF nurses and cardiologists. Therefore the aims of this study are; 1. Explore the type and number of perceived barriers of HF nurses and cardiologists to use a CDSS in the treatment of HF patients. 2. ...

  3. On the relationship between perceived importance of ERP systems selection characteristics and satisfaction with selected ERP systems in these characteristics

    DEFF Research Database (Denmark)

    Sudzina, Frantisek; Pucihar, Andreja; Lenart, Gregor

    2011-01-01

    of the relationship between the two. The paper focuses on the correlation between importance of ERP system selection criteria and the level of satisfaction with the chosen ERP systems in these characteristics. The research hypothesis is that there exists a correlation between the two. The analysis presented......Enterprise resource planning (ERP) systems have been widely adopted not only by large but still more even by small and medium enterprises. Although there had been some research conducted in ERP systems selection criteria and ERP systems satisfaction characteristics, very little was done in research...

  4. Development of energy selective neutron imaging system at HANARO

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jongyul; Kim, Jeong ho; Lee, Suhyun; Moon, Myung Kook; Kim, TaeJoo; Shin, Eun Joo; Woo, Wanchuck [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    Energy selective neutron imaging is one of advanced neutron imaging techniques because it is critical to examine the crystallographic phase distribution and spatial phase transformation for the development and application of new grade high-strength steels using energy selective neutron imaging. In this work, we are developing the energy selective neutron imaging system at the Ex-core Neutron irradiation Facility (ENF) for thermal neutron beam and the 18m Small Angle Neutron Scattering (18mSANS) beam line for cold neutron beam at HANARO. The energy selective neutron imaging system is being developed at the ENF and 18mSANS beam line at HANARO. We are expecting to get neutron radiographic images which can distinguish bcc and fcc phases in the prepared sample. The result of energy selective neutron imaging will provide the spatial distribution of the new deformation induced phase, which is important to make a relationship between phase transformation and mechanical behavior of the sample.

  5. Decontamination systems information and research program -- Literature review in support of development of standard test protocols and barrier design models for in situ formed barriers project

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-01

    The US Department of Energy is responsible for approximately 3,000 sites in which contaminants such as carbon tetrachloride, trichlorethylene, perchlorethylene, non-volatile and soluble organic and insoluble organics (PCBs and pesticides) are encountered. In specific areas of these sites radioactive contaminants are stored in underground storage tanks which were originally designed and constructed with a 30-year projected life. Many of these tanks are now 10 years beyond the design life and failures have occurred allowing the basic liquids (ph of 8 to 9) to leak into the unconsolidated soils below. Nearly one half of the storage tanks located at the Hanford Washington Reservation are suspected of leaking and contaminating the soils beneath them. The Hanford site is located in a semi-arid climate region with rainfall of less than 6 inches annually, and studies have indicated that very little of this water finds its way to the groundwater to move the water down gradient toward the Columbia River. This provides the government with time to develop a barrier system to prevent further contamination of the groundwater, and to develop and test remediation systems to stabilize or remove the contaminant materials. In parallel to remediation efforts, confinement and containment technologies are needed to retard or prevent the advancement of contamination plumes through the environment until the implementation of remediation technology efforts are completed. This project examines the various confinement and containment technologies and protocols for testing the materials in relation to their function in-situ.

  6. Goal Selection for Embedded Systems with Oversubscribed Resources

    Science.gov (United States)

    Rabideau, Gregg; Chien, Steve; McLaren, David

    2010-01-01

    We describe an efficient, online goal selection algorithm and its use for selecting goals at runtime. Our focus is on the re-planning that must be performed in a timely manner on the embedded system where computational resources are limited. In particular, our algorithm generates near optimal solutions to problems with fully specified goal requests that oversubscribe available resources but have no temporal flexibility. By using a fast, incremental algorithm, goal selection can be postponed in a "just-in-time" fashion allowing requests to be changed or added at the last minute. This enables shorter response cycles and greater autonomy for the system under control.

  7. Evaluation System and Actualization of Selection Supplier in ERP Enterprise

    Institute of Scientific and Technical Information of China (English)

    CAI Lan; GUO Shun-sheng; ZHANG Chan-jun

    2006-01-01

    Suppliers become an essential factor of enterprise competitiveness. The analytic hierarchy process is a kind of Decision-making method with the combination of quantity and quality. This paper presents the evaluation system of supplier selection, using Analytic Hierarchy Process (AHP) method to select the optimum supplier in Enterprise Resource Planning (ERP) enterprise. In order to reduce factor of manmade and increase exactitude, this paper innovates to use a real database in ERP system for evaluation. It also gives an example that one enterprise selects supplier.

  8. Clone Selection Algorithm with Niching Strategy for Computer Iune System

    Institute of Scientific and Technical Information of China (English)

    张雅静; 侯朝桢; 薛阳

    2004-01-01

    A clone selection algorithm for computer iune system is presented. Clone selection principles in biological iune system are applied to the domain of computer virus detection. Based on the negative selection algorithm proposed by Stephanie Forrest, combining mutation operator in genetic algorithms and niching strategy in biology is adopted, the number of detectors is decreased effectively and the ability on self-nonself discrimination is improved. Simulation experiment shows that the algorithm is simple, practical and is adapted to the discrimination for long files.

  9. Changes in skin barrier during treatment with systemic alitretinoin: focus on skin susceptibility and stratum corneum ceramides

    DEFF Research Database (Denmark)

    Jungersted, Jakob Mutanu; Høgh, Julie Kaae; Hellgren, Lars

    2010-01-01

    Alitretinoin is a new drug for systemic treatment of chronic hand eczema. Previous functional tests of skin topically treated with retinoids have indicated impaired skin barrier function, but no data are available on barrier parameters after systemic alitretinoin treatment. To investigate the eff....... No significant changes in stratum corneum lipids were found after 2 months of treatment. In conclusion, systemic alitretinoin does not influence skin susceptibility to irritants or the ceramide profile of stratum corneum....... the effect of systemic alitretinoin on skin barrier function and response to irritants, a secondary objective was to determine if changes occur in the lipid profile of stratum corneum after treatment with systemic alitretinoin. We conducted an open clinical intervention study on eight people ascribed......) was performed on the volar forearm and evaluated by trans-epidermal water loss (TEWL), erythema, and a cyanoacrylate skin sample was obtained for lipid analysis. We found no significant changes in response to SLS irritation as evaluated by TEWL and erythema, after treatment with alitretinoin for 2 months...

  10. Barriers of Proxemics and Kinesics Faced by Management with an Applicant from a Different Culture during a Selection Interview.

    Science.gov (United States)

    Bulusu, Aparna S.

    A literature review examined the potential impact of a multicultural applicant's nonverbal behavior (specifically, proxemics and kinesics) in a selection interview. Proxemics refers to the perception and use of personal and interpersonal space, which varies from culture to culture. The review indicated that in an interview situation, the chairs…

  11. PS1-56: Beyond Barriers: Systemic Constraints Limiting Sexual Health Care for Breast Cancer Survivors

    Science.gov (United States)

    Halley, Meghan; May, Suepattra; Rendle, Katharine; Frosch, Dominick; Kurian, Allison

    2013-01-01

    Background/Aims Sexual health problems represent one of the most frequently experienced and longest-lasting effects of breast cancer treatment, but research suggests that providers rarely discuss sexual health with their patients. Existing research examining barriers to addressing the sexual health concerns of cancer patients has focused on discrete characteristics of the provider-patient interaction without considering the broader context in which these interactions occur. Drawing on focus group discussions with breast cancer survivors, we explore how foundational cultural and structural characteristics of the healthcare system may be preventing breast cancer survivors from addressing their sexual health concerns. Methods Five focus groups were conducted with breast cancer survivors receiving support services at a breast cancer advocacy and resource organization in Northern California. Each group focused on a different aspect of treatment including: 1) diagnosis; 2) surgery and reconstruction; 3) chemotherapy; 4) radiation; and 5) survivorship. An interview guide for each topic area was used to elicit participants’ thoughts, opinions and experiences of breast cancer treatment. Analysis utilized inductive techniques incorporating elements of Grounded Theory to identify salient themes that emerged in the discussions. Results An average of eight women participated in each focus group, and women were allowed to participate in more than one group, for a total of 21 participants. Participants’ discussions illustrated three core ways in which cultural and structural characteristics of the healthcare system prevented them from addressing their sexual health concerns, including: 1) the structure of cancer care led to participants being disconnected from the healthcare system at the time when sexual side effects most commonly emerged; 2) when their sexual side effects did emerge, the highly specialized structure of the biomedical system made it difficult for patients to

  12. Selecting personnel to work on the interactive graphics system

    Energy Technology Data Exchange (ETDEWEB)

    Norton, F.J.

    1979-11-30

    The paper established criteria for the selection of personnel to work on the interactive graphics system and mentions some of human behavioral patterns that are created by the implementation of graphic systems. Some of the social and educational problems associated with the interactive graphics system will be discussed. The project also provided for collecting objective data which would be useful in assessing the benefits of interactive graphics systems.

  13. Marine debris is selected as nesting material by the brown booby (Sula leucogaster) within the Swain Reefs, Great Barrier Reef, Australia.

    Science.gov (United States)

    Verlis, K M; Campbell, M L; Wilson, S P

    2014-10-15

    Many seabirds are impacted by marine debris through its presence in foraging and nesting areas. To determine the extent of this problem, marine debris use in nest material of the brown booby (Sula leucogaster) in the Great Barrier Reef, Australia, was investigated. Nine cays were examined using beach and nest surveys. On average, four marine debris items were found per nest (n=96) with 58.3% of surveyed nests containing marine debris. The source of marine debris in nests and transects were primarily oceanic. Hard plastic items dominated both nest (56.8%) and surveyed beaches (72.8%), however only two item types were significantly correlated between these surveys. Nest surveys indicated higher levels of black and green items compared to beach transects. This selectivity for colours and items suggest these nests are not good indicators of environmental loads. This is the first study to examine S. leucogaster nests for marine debris in this location.

  14. Facilitators and barriers to doing workplace mental health research: Case study of acute psychological trauma in a public transit system.

    Science.gov (United States)

    Links, Paul S; Bender, Ash; Eynan, Rahel; O'Grady, John; Shah, Ravi

    2016-03-10

    The Acute Psychological Trauma (APT) Study was a collaboration between an acute care hospital, a specialized multidisciplinary program designed to meet the mental health needs of injured workers, and a large urban public transit system. The overall purpose was to evaluate a Best Practices Intervention (BPI) for employees affected by acute psychological trauma compared to a Treatment as Usual (TAU) group. The specific purpose is to discuss facilitators and barriers that were recognized in implementing and carrying out mental health research in a workplace setting. Over the course of the APT study, a joint implementation committee was responsible for day-to-day study operations and made regular observations on the facilitators and barriers that arose throughout the study. The facilitators to this study included the longstanding relationships among the partners, increased recognition for the need of mental health research in the workplace, and the existence of a community advisory committee. The significant barriers to doing this study of mental health research in the workplace included differences in organizational culture, inconsistent union support, co-interventions, and stigma. Researchers and funding agencies need to be flexible and provide additional resources in order to overcome the barriers that can exist doing workplace mental health research.

  15. Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review.

    Science.gov (United States)

    Bicker, Joana; Alves, Gilberto; Fortuna, Ana; Falcão, Amílcar

    2014-08-01

    During the research and development of new drugs directed at the central nervous system, there is a considerable attrition rate caused by their hampered access to the brain by the blood-brain barrier. Throughout the years, several in vitro models have been developed in an attempt to mimic critical functionalities of the blood-brain barrier and reliably predict the permeability of drug candidates. However, the current challenge lies in developing a model that retains fundamental blood-brain barrier characteristics and simultaneously remains compatible with the high throughput demands of pharmaceutical industries. This review firstly describes the roles of all elements of the neurovascular unit and their influence on drug brain penetration. In vitro models, including non-cell based and cell-based models, and in vivo models are herein presented, with a particular emphasis on their methodological aspects. Lastly, their contribution to the improvement of brain drug delivery strategies and drug transport across the blood-brain barrier is also discussed.

  16. Engineered Barrier System - Long-term Stability of Buffer and Backfill. Synthesis and extended abstracts

    Energy Technology Data Exchange (ETDEWEB)

    Apted, Mick; Arthur, Randy [Monitor Scientific LLC, Denver, CO (United States); Savage, Dave [Quintessa Ltd., Nottingham (GB)] (eds.)

    2005-09-15

    SKI is preparing to review the license applications being developed by the Swedish Nuclear Fuel and Waste Management Company (SKB) for an encapsulation plant and a deep repository for the geological disposal of spent nuclear fuel. As part of its preparation, SKI is conducting a series of technical workshops on key aspects of the Engineered Barrier System (EBS) of the repository. This workshop concerns the longterm stability of the buffer and the backfill. Previous workshops have addressed the overall concept for long-term integrity of the EBS, the manufacturing, testing and QA of the EBS and the performance confirmation for the EBS. The goal of this work is to achieve a comprehensive overview of all aspects of SKB's EBS work prior to the handling of forthcoming license applications. The reports from the EBS workshops will be used as one important basis in future review work. The workshops involve the gathering of a sufficient number of independent experts in different subjects of relevance to the particular aspect of EBS. A workshop starts with presentations and discussions among these experts. Following this, SKB presents recent results and responds to questions as part of an informal hearing. Finally, the independent experts and the SKI staff examine the SKB responses from different viewpoints. This report aims to summarise the issues discussed at the buffer and backfill workshop and to extract the essential viewpoints that have been expressed. The report is not a comprehensive record of the discussions and individual statements made by workshop participants should be regarded as opinions rather than proven facts. This reports includes apart from the workshop synthesis, questions to SKB identified prior or during the workshop, and extended abstracts for introductory presentations.

  17. Pathways and Hydrography in the Mesoamerican Barrier Reef System Part 1: Circulation

    Science.gov (United States)

    Carrillo, L.; Johns, E. M.; Smith, R. H.; Lamkin, J. T.; Largier, J. L.

    2015-10-01

    Acoustic Doppler Current Profiler (ADCP) measurements and surface drifters released from two oceanographic cruises conducted during March 2006 and January/February 2007 are used to investigate the circulation off the Mesoamerican Barrier Reef System (MBRS). We show that the MBRS circulation can be divided into two distinct regimes, a northern region dominated by the strong, northward-flowing Yucatan Current, and a southern region with weaker southward coastal currents and the presence of the Honduras Gyre. The latitude of impingement of the Cayman Current onto the coastline varies with time, and creates a third region, which acts as a boundary between the northern and southern circulation regimes. This circulation pattern yields two zones in terms of dispersal, with planktonic propagules in the northern region being rapidly exported to the north, whereas plankton in the southern and impingement regions may be retained locally or regionally. The latitude of the impingement region shifts interannually and intra-annually up to 3° in latitude. Sub-mesoscale features are observed in association with topography, e.g., flow bifurcation around Cozumel Island, flow wake north of Chinchorro Bank and separation of flow from the coast just north of Bahia de la Ascencion. This third feature is evident as cyclonic recirculation in coastal waters, which we call the Ascencion-Cozumel Coastal Eddy. An understanding of the implications of these different circulation regimes on water mass distributions, population connectivity, and the fate of land-based pollutants in the MBRS is critically important to better inform science-based resource management and conservation plans for the MBRS coral reefs.

  18. Experimental Studies of Engineered Barrier Systems Conducted at Los Alamos National Laboratory (FY16)

    Energy Technology Data Exchange (ETDEWEB)

    Caporuscio, Florie Andre [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Norskog, Katherine Elizabeth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Maner, James [Univ. of Oklahoma, Norman, OK (United States). School of Geology and Geophysics; Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Palaich, Sarah [Univ. of California, Los Angeles, CA (United States). Dept. of Earth, Planetary, and Space Sciences; Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Cheshire, Michael C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-08-04

    Over the past five years the Used Fuel Campaign has investigated Engineered Barrier Systems (EBS) at higher heat loads (up to 300°C) and pressure (150 bar). This past year experimental work was hindered due to a revamping of the hydrothermal lab. Regardless, two experiments were run this past year, EBS-18 and EBS-19. EBS-18 was run using Low Carbon Steel (LCS) and opalinus clay in addition to the bentonite and opalinus brine. Many of the past results were confirmed in EBS-18, such as the restriction of illite formation due to the bulk chemistry, pyrite degradation, and zeolite formation dependent on the bentonite and opalinus clay. The LCS show vast amounts of pit corrosion (over 100μm of corrosion in six weeks), leading a corrosion rate of 1083 μm/year. In addition, a mineral goethite, an iron-bearing hydroxide, formed in the pits of the LCS. Preliminary results from EBS-19 water chemistry are included but SEM imaging, micro probe and XRD are still needed for further results. Copper corrosion was investigated further and over 850 measurements were taken. It was concluded that pitting and pyrite degradation drastically increase the corrosion rate from 0.12 to 0.39 μm/day. However, the growth of a layer of the mineral chalcocite is thought to subdue the corrosion rate to 0.024 μm/day as observed in the EBS-13, a sixth month experiment. This document presents the findings of this past year.

  19. Experimental Studies of Engineered Barrier Systems Conducted at Los Alamos National Laboratory (FY16)

    Energy Technology Data Exchange (ETDEWEB)

    Caporuscio, Florie Andre [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Norskog, Katherine Elizabeth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Maner, James [Univ. of Oklahoma, Norman, OK (United States). School of Geology and Geophysics; Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Palaich, Sarah [Univ. of California, Los Angeles, CA (United States). Dept. of Earth, Planetary, and Space Sciences; Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Cheshire, Michael C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-08-04

    Over the past five years the Used Fuel Campaign has investigated Engineered Barrier Systems (EBS) at higher heat loads (up to 300°C) and pressure (150 bar). This past year experimental work was hindered due to a revamping of the hydrothermal lab. Regardless, two experiments were run this past year, EBS-18 and EBS-19. EBS-18 was run using Low Carbon Steel (LCS) and opalinus clay in addition to the bentonite and opalinus brine. Many of the past results were confirmed in EBS-18 such as the restriction of illite formation due to the bulk chemistry, pyrite degradation, and zeolite formation dependent on the bentonite and opalinus clay. The LCS show vast amounts of pit corrosion over 100μm of corrosion in six weeks, leading a corrosion rate of 1083 μm/year. In addition, a mineral goethite, an iron bearing hydroxide, formed in the pits of the LCS. Preliminary results from EBS-19 water chemistry are included but SEM imaging, micro probe and XRD are still needed for further results. Copper corrosion was investigated further and over 850 measurements were taken. It was concluded that pitting and pyrite degradation drastically increase the corrosion rate from 0.12 to 0.39 μm/day. However, the growth of a layer of the mineral chalcocite is thought to subdue the corrosion rate to 0.024 μm/day as observed in the EBS-13 a sixth month experiment. This document presents the findings of this past year.

  20. Automated simulation and evaluation of autostereoscopic multiview 3D display designs by time-sequential and wavelength-selective filter barrier

    Science.gov (United States)

    Kuhlmey, Mathias; Jurk, Silvio; Duckstein, Bernd; de la Barré, René

    2015-09-01

    A novel simulation tool has been developed for spatial multiplexed 3D displays. Main purpose of our software is the 3D display design with optical image splitter in particular lenticular grids or wavelength-selective barriers. As a result of interaction of image splitter with ray emitting displays a spatial light-modulator generating the autostereoscopic image representation was modeled. Based on the simulation model the interaction of optoelectronic devices with the defined spatial planes is described. Time-sequential multiplexing enables increasing the resolution of such 3D displays. On that reason the program was extended with an intermediate data cumulating component. The simulation program represents a stepwise quasi-static functionality and control of the arrangement. It calculates and renders the whole display ray emission and luminance distribution on viewing distance. The degree of result complexity will increase by using wavelength-selective barriers. Visible images at the viewer's eye positon were determined by simulation after every switching operation of optical image splitter. The summation and evaluation of the resulting data is processed in correspondence to the equivalent time sequence. Hereby the simulation was expanded by a complex algorithm for automated search and validation of possible solutions in the multi-dimensional parameter space. For the multiview 3D display design a combination of ray-tracing and 3D rendering was used. Therefore the emitted light intensity distribution of each subpixel will be evaluated by researching in terms of color, luminance and visible area by using different content distribution on subpixel plane. The analysis of the accumulated data will deliver different solutions distinguished by standards of evaluation.

  1. Measure Guideline: Selecting Ventilation Systems for Existing Homes

    Energy Technology Data Exchange (ETDEWEB)

    Aldrich, R.

    2014-02-01

    This document addresses adding -or improving - mechanical ventilation systems to existing homes. The purpose of ventilation is to remove contaminants from homes, and this report discusses where, when, and how much ventilation is appropriate in a home, including some discussion of relevant codes and standards. Advantages, disadvantages, and approximate costs of various system types are presented along with general guidelines for implementing the systems in homes. CARB intends for this document to be useful to decision makers and contractors implementing ventilation systems in homes. Choosing the "best" system is not always straightforward; selecting a system involves balancing performance, efficiency, cost, required maintenance, and several other factors. It is the intent of this document to assist contractors in making more informed decisions when selecting systems. Ventilation is an integral part of a high-performance home. With more air-sealed envelopes, a mechanical means of removing contaminants is critical for indoor environmental quality and building durability.

  2. The Development of Environmental Barrier Coating Systems for SiC-SiC Ceramic Matrix Composites: Environment Effects on the Creep and Fatigue Resistance

    Science.gov (United States)

    Zhu, Dongming; Ghosn, Louis J.

    2014-01-01

    Topics covered include: Environmental barrier coating system development: needs, challenges and limitations; Advanced environmental barrier coating systems (EBCs) for CMC airfoils and combustors; NASA EBC systems and material system evolutions, Current turbine and combustor EBC coating emphases, Advanced development, processing, testing and modeling, EBC and EBC bond coats: recent advances; Design tool and life prediction of coated CMC components; Advanced CMC-EBC rig demonstrations; Summary and future directions.

  3. Functionally gradient materials for thermal barrier coatings in advanced gas turbine systems

    Energy Technology Data Exchange (ETDEWEB)

    Banovic, S.W.; Barmak, K.; Chan, H.M. [Lehigh Univ., Bethlehem, PA (United States)] [and others

    1995-10-01

    New designs for advanced gas turbine engines for power production are required to have higher operating temperatures in order to increase efficiency. However, elevated temperatures will increase the magnitude and severity of environmental degradation of critical turbine components (e.g. combustor parts, turbine blades, etc{hor_ellipsis}). To offset this problem, the usage of thermal barrier coatings (TBCs) has become popular by allowing an increase in maximum inlet temperatures for an operating engine. Although thermal barrier technology is over thirty years old, the principle failure mechanism is the spallation of the ceramic coating at or near the ceramic/bond coat interface. Therefore, it is desirable to develop a coating that combines the thermal barrier qualities of the ceramic layer and the corrosion protection by the metallic bond coat without the detrimental effects associated with the localization of the ceramic/metal interface to a single plane.

  4. AN EXPERT SYSTEM MODEL FOR THE SELECTION OF TECHNICAL PERSONNEL

    Directory of Open Access Journals (Sweden)

    Emine COŞGUN

    2005-03-01

    Full Text Available In this study, a model has been developed for the selection of the technical personnel. In the model Visual Basic has been used as user interface, Microsoft Access has been utilized as database system and CLIPS program has been used as expert system program. The proposed model has been developed by utilizing expert system technology. In the personnel selection process, only the pre-evaluation of the applicants has been taken into consideration. Instead of replacing the expert himself, a decision support program has been developed to analyze the data gathered from the job application forms. The attached study will assist the expert to make faster and more accurate decisions.

  5. Identification of neuronal and angiogenic growth factors in an in vitro blood-brain barrier model system: Relevance in barrier integrity and tight junction formation and complexity.

    Science.gov (United States)

    Freese, Christian; Hanada, Sanshiro; Fallier-Becker, Petra; Kirkpatrick, C James; Unger, Ronald E

    2017-05-01

    We previously demonstrated that the co-cultivation of endothelial cells with neural cells resulted in an improved integrity of the in vitro blood-brain barrier (BBB), and that this model could be useful to evaluate the transport properties of potential central nervous system disease drugs through the microvascular brain endothelial. In this study we have used real-time PCR, fluorescent microscopy, protein arrays and enzyme-linked immunosorbent assays to determine which neural- and endothelial cell-derived factors are produced in the co-culture and improve the integrity of the BBB. In addition, a further improvement of the BBB integrity was achieved by adjusting serum concentrations and growth factors or by the addition of brain pericytes. Under specific conditions expression of angiogenic, angiostatic and neurotrophic factors such as endostatin, pigment epithelium derived factor (PEDF/serpins-F1), tissue inhibitor of metalloproteinases (TIMP-1), and vascular endothelial cell growth factor (VEGF) closely mimicked the in vivo situation. Freeze-fracture analysis of these cultures demonstrated the quality and organization of the endothelial tight junction structures and their association to the two different lipidic leaflets of the membrane. Finally, a multi-cell culture model of the BBB with a transendothelial electrical resistance up to 371 (±15) Ω×cm(2) was developed, which may be useful for preliminary screening of drug transport across the BBB and to evaluate cellular crosstalk of cells involved in the neurovascular unit.

  6. Effects of barrier fluctuation on the tunneling dynamics in the presence of classical chaos in a mixed quantum-classical system

    Indian Academy of Sciences (India)

    Aparna Saha; Bidhan Chandra Bag; Pranab Sarkar

    2007-03-01

    We present a numerical investigation of the tunneling dynamics of a particle moving in a bistable potential with fluctuating barrier which is coupled to a non-integrable classical system and study the interplay between classical chaos and barrier fluctuation in the tunneling dynamics. We found that the coupling of the quantum system with the classical subsystem decreases the tunneling rate irrespective of whether the classical subsystem is regular or chaotic and also irrespective of the fact that whether the barrier fluctuates or not. Presence of classical chaos always enhances the tunneling rate constant. The effect of barrier fluctuation on the tunneling rate in a mixed quantum-classical system is to suppress the tunneling rate. In contrast to the case of regular subsystem, the suppression arising due to barrier fluctuation is more visible when the subsystem is chaotic.

  7. Perceived barriers of heart failure nurses and cardiologists in using clinical decision support systems in the treatment of heart failure patients

    NARCIS (Netherlands)

    de Vries, Arjen E.; van der Wal, Martje H. L.; Nieuwenhuis, Maurice M. W.; de Jong, Richard M.; van Dijk, Rene B.; Jaarsma, Tiny; Hillege, Hans L.; Jorna, Rene J.

    2013-01-01

    Background: Clinical Decision Support Systems (CDSSs) can support guideline adherence in heart failure (HF) patients. However, the use of CDSSs is limited and barriers in working with CDSSs have been described as a major obstacle. It is unknown if barriers to CDSSs are present and differ between HF

  8. System Entropy and Its Application in Feature Selection

    Institute of Scientific and Technical Information of China (English)

    ZHAO Jun; WU Zhong-fu; LI Hua

    2004-01-01

    Feature selection is always an important issue in the research on data mining technologies. However, the problem of optimal feature selection is NP hard. Therefore, heuristic approaches are more practical to actual learning systems. Usually, that kind of algorithm selects features with the help of a heuristic metric compactum to measure the relative importance of features in a learning system. Here a new notion of 'system entropy' is described in terms of rough set theory, and then some of its algebraic characteristics are studied. After its intrinsic value biase is effectively counteracted, the system entropy is applied in BSE, a new heuristic algorithm for feature selection. BSE is efficient, whose time complexity is lower than that of analogous algorithms; BSE is also effective, which can produce the optimal results in the mini-feature biased sense from varieties of learning systems. Besides, BSE is tolerant and also flexible to the inconsistency of a learning system, consequently able to elegantly handle data noise in the learning system.

  9. Increased inspiratory esophagogastric junction pressure in systemic sclerosis: An add-on to antireflux barrier

    Science.gov (United States)

    Nobre e Souza, Miguel Ângelo; Bezerra, Patrícia Carvalho; Nobre, Rivianny Arrais; Holanda, Esther Studart da Fonseca; dos Santos, Armênio Aguiar

    2015-01-01

    AIM: To investigate crural diaphragm (CD) function in systemic sclerosis (SSc) using high-resolution manometry and standardized inspiratory maneuvers. METHODS: Eight SSc volunteers (average age, 40.1 years; one male) and 13 controls (average age, 32.2 years; six males) participated in the study. A high-resolution manometry/impedance system measured the esophagus and esophagogastric junction (EGJ) pressure profile during swallows and two respiratory maneuvers: sinus arrhythmia maneuver (SAM; the average of six EGJ peak pressures during 5-s deep inhalations) and threshold maneuver (TM; the EGJ peak pressures during forced inhalation under 12 and 24 cmH2O loads). Inspiratory diaphragm lowering (IDL) was taken as the displacement of the EGJ high-pressure zone during the SAM. RESULTS: SSc patients had lower mean lower esophageal sphincter pressure than controls during normal breathing (19.7 ± 2.8 mmHg vs 32.2 ± 2.7 mmHg, P = 0.007). Sinus arrhythmia maneuver pressure was higher in SSc patients than in controls (142.6 ± 9.4 mmHg vs 104.6 ± 13.8 mmHg, P = 0.019). Sinus arrhythmia maneuver pressure normalized to IDL was also higher in SSc patients than in controls (83.8 ± 13.4 mmHg vs 37.5 ± 6.9 mmHg, P = 0.005). Threshold maneuver pressures normalized to IDL were also greater in SSc patients than in controls (TM 12 cmH2O: 85.1 ± 16.4 mmHg vs 43.9 ± 6.3 mmHg, P = 0.039; TM 24 cmH2O: 85.2 ± 16.4 mmHg vs 46.2 ± 6.6 mmHg, P = 0.065). Inspiratory diaphragm lowering in SSc patients was less than in controls (2.1 ± 0.3 cm vs 3 ± 0.2 cm, P = 0.011). CONCLUSION: SSc patients had increased inspiratory EGJ pressure. This is an add-on to EGJ pressure and indicates that the antireflux barrier can be trained. PMID:25717239

  10. Barriers to screening mammography.

    Science.gov (United States)

    Sarma, Elizabeth A

    2015-01-01

    Breast cancer (BRCA) is the second most commonly diagnosed cancer among women in the USA, and mammography is an effective means for the early detection of BRCA. Identifying the barriers to screening mammography can inform research, policy and practice aiming to increase mammography adherence. A literature review was conducted to determine common barriers to screening mammography adherence. PsycINFO and PubMed databases were searched to identify studies published between 2000 and 2012 that examined barriers associated with reduced mammography adherence. Three thematic groups of barriers, based on social ecology, were identified from the literature: healthcare system-level, social and individual-level barriers. Researchers must consider screening behaviour in context and, therefore, should simultaneously consider each level of barriers when attempting to understand screening behaviour and create interventions to increase mammography adherence.

  11. Use of barrier membranes and systemic antibiotics in the treatment of intraosseous defects

    NARCIS (Netherlands)

    Loos, BG; Louwerse, PHG; van Winkelhoff, AJ; Burger, W; Gilijamse, M; Hart, AAM; van der Velden, U

    2002-01-01

    Objectives: Current literature is ambivalent on the use of barrier membranes for regeneration of intraosseous defects. One of the reasons for unpredictable results may be related to infection before, during and after the surgical procedure. Therefore, the purpose of the present controlled study was

  12. Quantifying system safety: A comparison of the SBOAT & Safety Barrier Manager tools

    DEFF Research Database (Denmark)

    Hansen, Zaza Nadja Lee; Duijm, Nijs Jan; Markert, Frank

    2015-01-01

    This paper presents two software tools for analyzing safety risks, SBOAT (Stochastic BPMN Optimisation and Analysis Tool) and SBM (SafetyBarrierManagerr). SBOAT employs principles from stochastic model checking to allow for the quantitative verification of workflows. SBM supports the creation...

  13. Systems pharmacology and blood-brain barrier functionality in Parkinson's disease

    NARCIS (Netherlands)

    Ravenstijn, Paulien Gerarda Maria

    2009-01-01

    Parkinson’s disease is a progressive neurodegenerative disease, which is composed of many components, each caused by interplay of a number of genetic and nongenetic causes. As the blood-brain barrier (BBB) is a key player in the relationship between plasma and brain pharmacokinetics, the influences

  14. No runoff, no soil loss: soil and water conservation in hedgerow barrier systems.

    NARCIS (Netherlands)

    Kiepe, P.

    1995-01-01

    Land degradation by water erosion represents a serious, and fast increasing, environmental threat. Hedgerow barriers control water erosion through the presence of the tree stem and through an increase in infiltration beneath the hedgerow. The infiltration rate beneath hedgerows is 3-8 times higher t

  15. Morphological response of a barrier island system on a catastrophic event

    DEFF Research Database (Denmark)

    Fruergaard, Mikkel; Kroon, Aart

    2016-01-01

    The AD 1634 North Sea storm is one of the most catastrophic storms along the Wadden Sea coast of Denmark. In this study we show how pre-1634 storm morphology exerted a strong control on the resulting post-storm coastal morphology. Erosional responses associated with the storm were barrier breachi...

  16. On the development of an expert system for wheelchair selection

    Science.gov (United States)

    Madey, Gregory R.; Bhansin, Charlotte A.; Alaraini, Sulaiman A.; Nour, Mohamed A.

    1994-01-01

    The presentation of wheelchairs for the Multiple Sclerosis (MS) patients involves the examination of a number of complicated factors including ambulation status, length of diagnosis, and funding sources, to name a few. Consequently, only a few experts exist in this area. To aid medical therapists with the wheelchair selection decision, a prototype medical expert system (ES) was developed. This paper describes and discusses the steps of designing and developing the system, the experiences of the authors, and the lessons learned from working on this project. Wheelchair Advisor, programmed in CLIPS, serves as diagnosis, classification, prescription, and training tool in the MS field. Interviews, insurance letters, forms, and prototyping were used to gain knowledge regarding the wheelchair selection problem. Among the lessons learned are that evolutionary prototyping is superior to the conventional system development life-cycle (SDLC), the wheelchair selection is a good candidate for ES applications, and that ES can be applied to other similar medical subdomains.

  17. The Selection of Cooling systems of Giant Hydro-Generators

    Institute of Scientific and Technical Information of China (English)

    Li Dingzhong

    2010-01-01

    @@ The selection of cooling system for hydro-generator in Ertan Hydropower Station is reviewed in this pap(ar) The new viewpoint on air-cooled system of hydraul(is)generator of recent years is analyzed and described. That is, "Full air-cooled system is always preferred to inner water cooling system in hydro-generator." Moreov() the decision process and corresponding actions of aircooled system design for hydro-generator in Longtan Hydropower Station, Xiaowan Hydropower Station and Laxiwa Hydropower Station are introduced.

  18. A Study on the Thermal-Hydro-Mechanical Behaviors in the Engineered Barrier System of a HLW Repository: Engineering-scale Validation Test

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jae-Owan; Kwon, S. K.; Park, J. H.; Cho, W. J.; Lee, Jae-Owan

    2007-06-15

    The T-H-M processes in the engineered barrier system are one of the major issues in the performance assessment of a HLW repository. In this study, it was conducted to design and construct the engineering-scale test facility which was a third-scale of the reference disposal system, and to investigate THM behavior of the engineered barrier system using the test facility. The computer modeling and interpreting methodology for THM behavior were also developed.

  19. Methods, apparatus and system for selective duplication of subtasks

    Energy Technology Data Exchange (ETDEWEB)

    Andrade Costa, Carlos H.; Cher, Chen-Yong; Park, Yoonho; Rosenburg, Bryan S.; Ryu, Kyung D.

    2016-03-29

    A method for selective duplication of subtasks in a high-performance computing system includes: monitoring a health status of one or more nodes in a high-performance computing system, where one or more subtasks of a parallel task execute on the one or more nodes; identifying one or more nodes as having a likelihood of failure which exceeds a first prescribed threshold; selectively duplicating the one or more subtasks that execute on the one or more nodes having a likelihood of failure which exceeds the first prescribed threshold; and notifying a messaging library that one or more subtasks were duplicated.

  20. A Fuzzy-MOORA approach for ERP system selection

    Directory of Open Access Journals (Sweden)

    Prasad Karande

    2012-07-01

    Full Text Available In today’s global and dynamic business environment, manufacturing organizations face the tremendous challenge of expanding markets and meeting the customer expectations. It compels them to lower total cost in the entire supply chain, shorten throughput time, reduce inventory, expand product choice, provide more reliable delivery dates and better customer service, improve quality, and efficiently coordinate demand, supply and production. In order to accomplish these objectives, the manufacturing organizations are turning to enterprise resource planning (ERP system, which is an enterprise-wide information system to interlace all the necessary business functions, such as product planning, purchasing, inventory control, sales, financial and human resources into a single system having a shared database. Thus to survive in the global competitive environment, implementation of a suitable ERP system is mandatory. However, selecting a wrong ERP system may adversely affect the manufacturing organization’s overall performance. Due to limitations in available resources, complexity of ERP systems and diversity of alternatives, it is often difficult for a manufacturing organization to select and install the most suitable ERP system. In this paper, two ERP system selection problems are solved using fuzzy multi-objective optimization on the basis of ratio analysis (MOORA method and it is observed that in both the cases, SAP is the best solution.

  1. Numerical determination of the interfacial energy and nucleation barrier of curved solid-liquid interfaces in binary systems.

    Science.gov (United States)

    Kundin, Julia; Choudhary, Muhammad Ajmal

    2016-07-01

    The phase-field crystal (PFC) technique is a widely used approach for modeling crystal growth phenomena with atomistic resolution on mesoscopic time scales. We use a two-dimensional PFC model for a binary system based on the work of Elder et al. [Phys. Rev. B 75, 064107 (2007)PRBMDO1098-012110.1103/PhysRevB.75.064107] to study the effect of the curved, diffuse solid-liquid interface on the interfacial energy as well as the nucleation barrier. The calculation of the interfacial energy and the nucleation barrier certainly depends on the proper definition of the solid-liquid dividing surface and the corresponding nucleus size. We define the position of the sharp interface at which the interfacial energy is to be evaluated by using the concept of equimolar dividing surface (r^{e}) and the minimization of the interfacial energy (r^{s}). The comparison of the results based on both radii shows that the difference r^{e}-r^{s} is always positive and has a limit for large cluster sizes which is comparable to the Tolman length. Furthermore, we found the real nucleation barrier for small cluster sizes, which is defined as a function of the radius r^{s}, and compared it with the classical nucleation theory. The simulation results also show that the extracted interfacial energy as function of both radii is independent of system size, and this dependence can be reasonably described by the nonclassical Tolman formula with a positive Tolman length.

  2. Health system and societal barriers for gestational diabetes mellitus (GDM) services - lessons from World Diabetes Foundation supported GDM projects

    DEFF Research Database (Denmark)

    Nielsen, Karoline Kragelund; de Courten, Maximilian; Kapur, Anil

    2012-01-01

    Background Maternal mortality and morbidity remains high in many low- and middle-income countries (LMIC). Gestational Diabetes Mellitus (GDM) represents an underestimated and unrecognised impediment to optimal maternal health in LMIC; left untreated – it also has severe consequences for the offsp......Background Maternal mortality and morbidity remains high in many low- and middle-income countries (LMIC). Gestational Diabetes Mellitus (GDM) represents an underestimated and unrecognised impediment to optimal maternal health in LMIC; left untreated – it also has severe consequences...... for the offspring. A better understanding of the barriers hindering detection and treatment of GDM is needed. Based on experiences from World Diabetes Foundation (WDF) supported GDM projects this paper seeks to investigate societal and health system barriers to such efforts. Methods Questionnaires were filled out...

  3. Symmetric splitting for the system /sup 32/S+/sup 238/U at energies near and below the barrier

    Energy Technology Data Exchange (ETDEWEB)

    Freifelder, R.; Braun-Munzinger, P.; DeYoung, P.; Schicker, R.; Sen, S.; Stachel, J.

    1987-06-01

    The total capture cross section for the system /sup 32/S+/sup 238/U has been measured at energies from 0.93 to 1.08 times the s-wave interaction barrier by detecting coincident fission fragments following full momentum transfer reactions. The subbarrier cross section cannot be reproduced by a one-dimensional barrier penetration model. Using a quantum mechanical coupled channels model, good agreement is obtained. The measured angular distributions of fission fragments were compared to the predictions of saddle and scission point transition state theory. Saddle point transition state model calculations fail to reproduce the data, while scission point transition state calculations are in agreement with their qualitative trend. Evidence for nonequilibrium processes is presented.

  4. Health system barriers and facilitators to medication adherence for the secondary prevention of cardiovascular disease: a systematic review

    Science.gov (United States)

    Banerjee, Amitava; Khandelwal, Shweta; Nambiar, Lavanya; Saxena, Malvika; Peck, Victoria; Moniruzzaman, Mohammed; Faria Neto, Jose Rocha; Quinto, Katherine Curi; Smyth, Andrew; Leong, Darryl; Werba, José Pablo

    2016-01-01

    Background Secondary prevention is cost-effective for cardiovascular disease (CVD), but uptake is suboptimal. Understanding barriers and facilitators to adherence to secondary prevention for CVD at multiple health system levels may inform policy. Objectives To conduct a systematic review of barriers and facilitators to adherence/persistence to secondary CVD prevention medications at health system level. Methods Included studies reported effects of health system level factors on adherence/persistence to secondary prevention medications for CVD (coronary artery or cerebrovascular disease). Studies considered at least one of β blockers, statins, angiotensin–renin system blockers and aspirin. Relevant databases were searched from 1 January 1966 until 1 October 2015. Full texts were screened for inclusion by 2 independent reviewers. Results Of 2246 screened articles, 25 studies were included (12 trials, 11 cohort studies, 1 cross-sectional study and 1 case–control study) with 132 140 individuals overall (smallest n=30, largest n=63 301). 3 studies included upper middle-income countries, 1 included a low middle-income country and 21 (84%) included high-income countries (9 in the USA). Studies concerned established CVD (n=4), cerebrovascular disease (n=7) and coronary heart disease (n=14). Three studies considered persistence and adherence. Quantity and quality of evidence was limited for adherence, persistence and across drug classes. Studies were concerned with governance and delivery (n=19, including 4 trials of fixed-dose combination therapy, FDC), intellectual resources (n=1), human resources (n=1) and health system financing (n=4). Full prescription coverage, reduced copayments, FDC and counselling were facilitators associated with higher adherence. Conclusions High-quality evidence on health system barriers and facilitators to adherence to secondary prevention medications for CVD is lacking, especially for low-income settings. Full prescription coverage

  5. Investigation of the Mechanical Performance of Compliant Thermal Barriers

    Science.gov (United States)

    DeMange, Jeffrey J.; Bott, Robert J.; Dunlap, Patrick H.

    2011-01-01

    Compliant thermal barriers play a pivotal role in the thermal protection systems of advanced aerospace vehicles. Both the thermal properties and mechanical performance of these barriers are critical in determining their successful implementation. Due to the custom nature of many thermal barriers, designers of advanced spacecraft have little guidance as to the design, selection, and implementation of these elements. As part of an effort to develop a more fundamental understanding of the interrelationship between thermal barrier design and performance, mechanical testing of thermal barriers was conducted. Two different types of thermal barriers with several core insulation density levels ranging from 62 to 141 kg/cu m were investigated. Room-temperature compression tests were conducted on samples to determine load performance and assess thermal barrier resiliency. Results showed that the loading behavior of these thermal barriers was similar to other porous, low-density, compliant materials, such as elastomeric foams. Additionally, the insulation density level had a significant non-linear impact on the stiffness and peak loads of the thermal barriers. In contrast, neither the thermal barrier type nor the level of insulation density significantly influenced the room-temperature resiliency of the samples.

  6. Rough Set Fuzzy Optimum Selecting in Multidisciplinary System

    Institute of Scientific and Technical Information of China (English)

    LIU Xu-lin; SONG Bao-wei; WANG Jin-hua; CHEN Jie

    2008-01-01

    Scheme evaluation and selection is an optimum selecting and sequencing problem with multi-objective and multi- level. It can't follow single objective function or rule. Meanwhile, these objectives are coupled with each other and the at- tribution information is fuzzy also. It is necessary to find an effective evaluation method which can consider all conditions and restrictions. In this paper, AHP and rough set theory are applied to fuzzy optimization to determine important weight of each attribution. The rough set fuzzy optimum selection is used to eliminate the useless information. Autonomous un- derwater vehicle (AUV) is large-scah systems with many coupled design variables and objective functions. Their scheme evaluation and selection are very important, which relate to multiple factors, such as reliability;security, service time; the lifeeyele, etc. Results of application in torpedo design indicate that this method is feasible.

  7. Neural mechanisms of selective attention in the somatosensory system.

    Science.gov (United States)

    Gomez-Ramirez, Manuel; Hysaj, Kristjana; Niebur, Ernst

    2016-09-01

    Selective attention allows organisms to extract behaviorally relevant information while ignoring distracting stimuli that compete for the limited resources of their central nervous systems. Attention is highly flexible, and it can be harnessed to select information based on sensory modality, within-modality feature(s), spatial location, object identity, and/or temporal properties. In this review, we discuss the body of work devoted to understanding mechanisms of selective attention in the somatosensory system. In particular, we describe the effects of attention on tactile behavior and corresponding neural activity in somatosensory cortex. Our focus is on neural mechanisms that select tactile stimuli based on their location on the body (somatotopic-based attention) or their sensory feature (feature-based attention). We highlight parallels between selection mechanisms in touch and other sensory systems and discuss several putative neural coding schemes employed by cortical populations to signal the behavioral relevance of sensory inputs. Specifically, we contrast the advantages and disadvantages of using a gain vs. spike-spike correlation code for representing attended sensory stimuli. We favor a neural network model of tactile attention that is composed of frontal, parietal, and subcortical areas that controls somatosensory cells encoding the relevant stimulus features to enable preferential processing throughout the somatosensory hierarchy. Our review is based on data from noninvasive electrophysiological and imaging data in humans as well as single-unit recordings in nonhuman primates.

  8. Designing a fuzzy expert system for selecting knowledge management strategy

    Directory of Open Access Journals (Sweden)

    Ameneh Khadivar

    2014-12-01

    Full Text Available knowledge management strategy is mentioned as one of the most important success factors for implementing knowledge management. The KM strategy selection is a complex decision that requires consideration of several factors. For evaluation and selection of an appropriate knowledge management strategy in organizations, many factors must be considered. The identified factors and their impact on knowledge management strategy are inherently ambiguous. In this study, an overview of theoretical foundations of research regarding the different knowledge management strategies has been done And factors influencing the knowledge management strategy selection have been extracted from conceptual frameworks and models. How these factors influence the knowledge management strategy selection is extracted through the fuzzy Delphi. Next a fuzzy expert system for the selection of appropriate knowledge management strategy is designed with respect to factors that have an impact on knowledge management strategy. The factors which influence the selection of knowledge management strategy include: general business strategy, organizational structure, cultural factors, IT strategy, strategic human resource management, social level, the types of knowledge creation processes and release it. The factors which influence the knowledge management strategy selection include: business strategy general, organizational structure, cultural factors, IT strategy, human resource management strategies, socialization level, knowledge types and its creation and diffusion processes. According to identified factors which affect the knowledge management strategy, the final strategy is recommended based on the range of human-oriented and system-oriented by keep the balance of explicit and implicit knowledge. The Designed system performance is tested and evaluated by the information related to three Iranian organization.

  9. Selecting a Relational Database Management System for Library Automation Systems.

    Science.gov (United States)

    Shekhel, Alex; O'Brien, Mike

    1989-01-01

    Describes the evaluation of four relational database management systems (RDBMSs) (Informix Turbo, Oracle 6.0 TPS, Unify 2000 and Relational Technology's Ingres 5.0) to determine which is best suited for library automation. The evaluation criteria used to develop a benchmark specifically designed to test RDBMSs for libraries are discussed. (CLB)

  10. STRATEGY FOR EVALUATION AND SELECTION OF SYSTEMS FOR ELECTRONIC LEARNING

    Directory of Open Access Journals (Sweden)

    Dubravka Mandušić

    2012-12-01

    Full Text Available Today`s technology supported and accelerated learning time requires constant and continuous acquisition of new knowledge. On the other hand, it does not leave enough time for additional education. Increasing number of E-learning systems, withdraws a need for precise evaluation of functionality that those systems provide; so they could be reciprocally compared. While implementing new systems for electronic learning, it is very important to pre-evaluate existing systems in order to select the one that meets all defined parameters, with low costs/investment. Proper evaluation can save time and money.

  11. Selection and Simulation of Electric Steering Gear Control System

    Directory of Open Access Journals (Sweden)

    Xin Wang

    2013-06-01

    Full Text Available For the electric steering gear control systems, the principle of the system is introduced. Specific model and parameters are selected to deduce the optimal combination of control system and choices method of the steering system model is determined. The transfer function of motor according to the parameters is achieved and simulation results are gained based on MATLAB. Simulation results show that this method can meet the performance requirements of electric steering gear, the control method is simple and easy to work to achieve.

  12. Measure Guideline: Selecting Ventilation Systems for Existing Homes

    Energy Technology Data Exchange (ETDEWEB)

    Aldrich, R. [Consortium for Advanced Residential Buildings (CARB), Norwalk, CT (United States)

    2014-02-01

    This report, developed by Building America research team CARB, addresses adding or improving mechanical ventilation systems to existing homes. The goal of this report is to assist decision makers and contractors in making informed decisions when selecting ventilation systems for homes. With more air-sealed envelopes, a mechanical means of removing contaminants is critical for indoor environmental quality and building durability. The purpose of ventilation is to remove contaminants from homes, and this report discusses where, when, and how much ventilation is appropriate in a home, including examination of relevant codes and standards. Choosing the "best" system is not always straightforward; selecting a system involves balancing performance, efficiency, cost, required maintenance, and several other factors.

  13. Selecting a clinical intervention documentation system for an academic setting.

    Science.gov (United States)

    Fox, Brent I; Andrus, Miranda; Hester, E Kelly; Byrd, Debbie C

    2011-03-10

    Pharmacists' clinical interventions have been the subject of a substantial body of literature that focuses on the process and outcomes of establishing an intervention documentation program within the acute care setting. Few reports describe intervention documentation as a component of doctor of pharmacy (PharmD) programs; none describe the process of selecting an intervention documentation application to support the complete array of pharmacy practice and experiential sites. The process that a school of pharmacy followed to select and implement a school-wide intervention system to document the clinical and financial impact of an experiential program is described. Goals included finding a tool that allowed documentation from all experiential sites and the ability to assign dollar savings (hard and soft) to all documented interventions. The paper provides guidance for other colleges and schools of pharmacy in selecting a clinical intervention documentation system for program-wide use.

  14. Blanch Resistant and Thermal Barrier NiAl Coating Systems for Advanced Copper Alloys

    Science.gov (United States)

    Raj, Sai V. (Inventor)

    2005-01-01

    A method of forming an environmental resistant thermal barrier coating on a copper alloy is disclosed. The steps include cleansing a surface of a copper alloy, depositing a bond coat on the cleansed surface of the copper alloy, depositing a NiAl top coat on the bond coat and consolidating the bond coat and the NiAl top coat to form the thermal barrier coating. The bond coat may be a nickel layer or a layer composed of at least one of copper and chromium-copper alloy and either the bond coat or the NiAl top coat or both may be deposited using a low pressure or vacuum plasma spray.

  15. THE ROTATION BARRIER OF ELECTRON SPIN PROBE IN THE STUDY OF POLYMER SYSTEM

    Institute of Scientific and Technical Information of China (English)

    YU Tongyin; GUO Shiqing; GE Mingtao

    1984-01-01

    In the study of molecular motion of polymer by means of ESR in combination with spin probe,owing to that the ESR spectrum depicts only the behavior of spin probe, the information obtained is of indirect nature. Hence the relationship between them must first be investigated before any conclusion could be drawn. In this paper, two parameters TR and CR are introduced to characterize the changing of tumbling rate of spin probe, and the concept of rotation barrier of spin probe is proposed. It is considered that the magnitude of the rotation barrier is determined by the internal cavity size and distribution in polymer. When the temperature is raised, the size and distribution of the cavities change accordingly, thus the tumbling of spin probe changes gradually from a slower to a higher rate.

  16. Investing in Computer Technology: Criteria and Procedures for System Selection.

    Science.gov (United States)

    Hofstetter, Fred T.

    The criteria used by the University of Delaware in selecting the PLATO computer-based educational system are discussed in this document. Consideration was given to support for instructional strategies, requirements of the student learning station, features for instructors and authors of instructional materials, general operational characteristics,…

  17. Corneal manifestations of selected systemic diseases: A review

    Directory of Open Access Journals (Sweden)

    Wayne D.H. Gillan

    2015-03-01

    Full Text Available The corneal manifestations of several selected systemic diseases are reviewed. Metabolic, immunologic and inflammatory and infectious diseases are included. A brief overview of each disease and how it manifests in the cornea is discussed. The importance of conducting a slit-lamp examination on every patient is emphasised.

  18. Horizontal flow barriers for the transient ground-water flow model, Death Valley regional ground-water flow system, Nevada and California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This digital dataset defines the surface traces of regional features simulated as horizontal flow barriers in the Death Valley regional ground-water flow system...

  19. Reactor technology assessment and selection utilizing systems engineering approach

    Science.gov (United States)

    Zolkaffly, Muhammed Zulfakar; Han, Ki-In

    2014-02-01

    The first Nuclear power plant (NPP) deployment in a country is a complex process that needs to consider technical, economic and financial aspects along with other aspects like public acceptance. Increased interest in the deployment of new NPPs, both among newcomer countries and those with expanding programs, necessitates the selection of reactor technology among commercially available technologies. This paper reviews the Systems Decision Process (SDP) of Systems Engineering and applies it in selecting the most appropriate reactor technology for the deployment in Malaysia. The integrated qualitative and quantitative analyses employed in the SDP are explored to perform reactor technology assessment and to select the most feasible technology whose design has also to comply with the IAEA standard requirements and other relevant requirements that have been established in this study. A quick Malaysian case study result suggests that the country reside with PWR (pressurized water reactor) technologies with more detailed study to be performed in the future for the selection of the most appropriate reactor technology for Malaysia. The demonstrated technology assessment also proposes an alternative method to systematically and quantitatively select the most appropriate reactor technology.

  20. Identifying barriers to mental health system improvements: an examination of community participation in assertive community treatment programs

    Directory of Open Access Journals (Sweden)

    Wakefield Patricia A

    2011-11-01

    Full Text Available Abstract Background Integrating the best available evidence into program standards is essential if system-wide improvements in the delivery of community-based mental health services are to be achieved. Since the beginning of the Assertive Community Treatment (ACT program movement, program standards have included a role for the community. In particular, ACT program standards have sought to ensure that members of the local community are involved in governance and that former clients participate in service delivery as "Peer Support Specialists". This paper reports on the extent to which ACT program standards related to community participation have been implemented and identifies barriers to full compliance. Methods Qualitative and quantitative data were collected through a telephone survey of ACT Program Coordinators in Ontario, Canada, using a census sample of the existing 66 ACT programs. A thematic approach to content analysis was used to analyze respondents' qualitative comments. Quantitative data were analyzed using SPSS 16.0 and included means, frequencies, independent t-tests and Pearson Correlations. Results An 85% response rate was achieved. Of the 33 program standards, the two that received the lowest perceived compliance ratings were the two standards directly concerning community participation. Specifically, the standard to have a functioning Community Advisory Body and the standard requiring the inclusion of a Peer Support Specialist. The three major themes that emerged from the survey data with respect to the barriers to fully implementing the Community Advisory Body were: external issues; standard related issues; and, organizational/structural related issues. The three major themes concerning barriers to implementing the Peer Support Specialist role were: human resource related issues; organizational/structural related issues; and, standard related issues. Conclusions The reasons for low compliance of ACT programs with community

  1. Optimal Subinterval Selection Approach for Power System Transient Stability Simulation

    Directory of Open Access Journals (Sweden)

    Soobae Kim

    2015-10-01

    Full Text Available Power system transient stability analysis requires an appropriate integration time step to avoid numerical instability as well as to reduce computational demands. For fast system dynamics, which vary more rapidly than what the time step covers, a fraction of the time step, called a subinterval, is used. However, the optimal value of this subinterval is not easily determined because the analysis of the system dynamics might be required. This selection is usually made from engineering experiences, and perhaps trial and error. This paper proposes an optimal subinterval selection approach for power system transient stability analysis, which is based on modal analysis using a single machine infinite bus (SMIB system. Fast system dynamics are identified with the modal analysis and the SMIB system is used focusing on fast local modes. An appropriate subinterval time step from the proposed approach can reduce computational burden and achieve accurate simulation responses as well. The performance of the proposed method is demonstrated with the GSO 37-bus system.

  2. A MULTI-CRC SELECTIVE HARQ SCHEME FOR MIMO SYSTEMS

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A multi-Cyclic Redundancy Check (CRC) selective Hybrid Automatic-Repeat-reQuest (HARQ) scheme for improving the throughput efficiency of Multiple Input Multiple Output (MIMO) systems is proposed in this paper. According to different feedback information from the receiver, the proposed HARQ scheme employs two strategies, referred to as retransmission frame selection and space diversity. These two strategies decrease the successive frame errors upon retransmission. Theoretic analysis and computer simulation results show that this HARQ scheme achieves higher throughput than the existing HARQ schemes even in poor conditions of low Signal-to-Noise Ratio (SNR).

  3. Sensor Selection method for IoT systems – focusing on embedded system requirements

    Directory of Open Access Journals (Sweden)

    Hirayama Masayuki

    2016-01-01

    Full Text Available Recently, various types of sensors have been developed. Using these sensors, IoT systems have become hot topics in embedded system domain. However, sensor selections for embedded systems are not well discussed up to now. This paper focuses on embedded system’s features and architecture, and proposes a sensor selection method which is composed seven steps. In addition, we applied the proposed method to a simple example – a sensor selection for computer scored answer sheet reader unit. From this case study, an idea to use FTA in sensor selection is also discussed.

  4. Near-Surface Engineered Environmental Barrier Integrity

    Energy Technology Data Exchange (ETDEWEB)

    Piet, Steven James; Breckenridge, Robert Paul; Beller, John Michael; Geesey, Gill Gregroy; Glenn, David Frankie; Jacobson, Jacob Jordan; Martian, Pete; Matthern, Gretchen Elise; Mattson, Earl Douglas; Porro, Indrek; Southworth, Finis Hio; Steffler, Eric Darwin; Stormberg, Angelica Isabel; Stormberg, Gregory John; Versteeg, Roelof Jan; White, Gregory J

    2002-08-01

    The INEEL Environmental Systems Research and Analysis (ESRA) program has launched a new R&D project on Near-Surface Engineered Environmental Barrier Integrity to increase knowledge and capabilities for using engineering and ecological components to improve the integrity of near-surface barriers used to confine contaminants from the public and the environment. The knowledge gained and the capabilities built will help verify the adequacy of past remedial decisions and enable improved solutions for future cleanup decisions. The research is planned to (a) improve the knowledge of degradation mechanisms (weathering, biological, geological, chemical, radiological, and catastrophic) in times shorter than service life, (b) improve modeling of barrier degradation dynamics, (c) develop sensor systems to identify degradation prior to failure, and (d) provide a better basis for developing and testing of new barrier systems to increase reliability and reduce the risk of failure. Our project combines selected exploratory studies (benchtop and field scale), coupled effects accelerated aging testing and the meso-scale, testing of new monitoring concepts, and modeling of dynamic systems. The performance of evapo- transpiration, capillary, and grout-based barriers will be examined.

  5. Near-Surface Engineered Environmental Barrier Integrity

    Energy Technology Data Exchange (ETDEWEB)

    Piet, S.J.; Breckenridge, R.P.

    2002-05-15

    The INEEL Environmental Systems Research and Analysis (ESRA) program has launched a new R and D project on Near-Surface Engineered Environmental Barrier Integrity to increase knowledge and capabilities for using engineering and ecological components to improve the integrity of near-surface barriers used to confine contaminants from the public and the environment. The knowledge gained and the capabilities built will help verify the adequacy of past remedial decisions and enable improved solutions for future cleanup decisions. The research is planned to (a) improve the knowledge of degradation mechanisms (weathering, biological, geological, chemical, radiological, and catastrophic) in times shorter than service life, (b) improve modeling of barrier degradation dynamics, (c) develop sensor systems to identify degradation prior to failure, and (d) provide a better basis for developing and testing of new barrier systems to increase reliability and reduce the risk of failure. Our project combine s selected exploratory studies (benchtop and field scale), coupled effects accelerated aging testing and the meso-scale, testing of new monitoring concepts, and modeling of dynamic systems. The performance of evapo-transpiration, capillary, and grout-based barriers will be examined.

  6. Recycler barrier RF buckets

    Energy Technology Data Exchange (ETDEWEB)

    Bhat, C.M.; /Fermilab

    2011-03-01

    The Recycler Ring at Fermilab uses a barrier rf systems for all of its rf manipulations. In this paper, I will give an overview of historical perspective on barrier rf system, the longitudinal beam dynamics issues, aspects of rf linearization to produce long flat bunches and methods used for emittance measurements of the beam in the RR barrier rf buckets. Current rf manipulation schemes used for antiproton beam stacking and longitudinal momentum mining of the RR beam for the Tevatron collider operation are explained along with their importance in spectacular success of the Tevatron luminosity performance.

  7. Attitude towards the incorporation of the selective collection of biowaste in a municipal solid waste management system. A case study

    Energy Technology Data Exchange (ETDEWEB)

    Bernad-Beltrán, D. [Department of Mechanical Engineering and Construction, Universitat Jaume I, Av Sos Baynat s/n, E12071 Castellón (Spain); Simó, A. [Department of Mathematics, Universitat Jaume I, Av Sos Baynat s/n, E12071 Castellón (Spain); Bovea, M.D., E-mail: bovea@uji.es [Department of Mechanical Engineering and Construction, Universitat Jaume I, Av Sos Baynat s/n, E12071 Castellón (Spain)

    2014-12-15

    Highlights: • Attitude towards incorporating biowaste selective collection is analysed. • Willingness to participate and to pay in biowaste selective collection is obtained. • Socioeconomic aspects affecting WtParticipate and WtPay are identified. - Abstract: European waste legislation has been encouraging for years the incorporation of selective collection systems for the biowaste fraction. European countries are therefore incorporating it into their current municipal solid waste management (MSWM) systems. However, this incorporation involves changes in the current waste management habits of households. In this paper, the attitude of the public towards the incorporation of selective collection of biowaste into an existing MSWM system in a Spanish municipality is analysed. A semi-structured telephone interview was used to obtain information regarding aspects such as: level of participation in current waste collection systems, willingness to participate in selective collection of biowaste, reasons and barriers that affect participation, willingness to pay for the incorporation of the selective collection of biowaste and the socioeconomic characteristics of citizens who are willing to participate and pay for selective collection of biowaste. The results showed that approximately 81% of the respondents were willing to participate in selective collection of biowaste. This percentage would increase until 89% if the Town Council provided specific waste bins and bags, since the main barrier to participate in the new selective collection system is the need to use specific waste bin and bags for the separation of biowaste. A logit response model was applied to estimate the average willingness to pay, obtaining an estimated mean of 7.5% on top of the current waste management annual tax. The relationship of willingness to participate and willingness to pay for the implementation of this new selective collection with the socioeconomic variables (age, gender, size of the

  8. Machine-Vision Systems Selection for Agricultural Vehicles: A Guide

    Directory of Open Access Journals (Sweden)

    Gonzalo Pajares

    2016-11-01

    Full Text Available Machine vision systems are becoming increasingly common onboard agricultural vehicles (autonomous and non-autonomous for different tasks. This paper provides guidelines for selecting machine-vision systems for optimum performance, considering the adverse conditions on these outdoor environments with high variability on the illumination, irregular terrain conditions or different plant growth states, among others. In this regard, three main topics have been conveniently addressed for the best selection: (a spectral bands (visible and infrared; (b imaging sensors and optical systems (including intrinsic parameters and (c geometric visual system arrangement (considering extrinsic parameters and stereovision systems. A general overview, with detailed description and technical support, is provided for each topic with illustrative examples focused on specific applications in agriculture, although they could be applied in different contexts other than agricultural. A case study is provided as a result of research in the RHEA (Robot Fleets for Highly Effective Agriculture and Forestry Management project for effective weed control in maize fields (wide-rows crops, funded by the European Union, where the machine vision system onboard the autonomous vehicles was the most important part of the full perception system, where machine vision was the most relevant. Details and results about crop row detection, weed patches identification, autonomous vehicle guidance and obstacle detection are provided together with a review of methods and approaches on these topics.

  9. Thermal/residual stress in an electron beam physical vapor deposited thermal barrier coating system

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, J.; Jordan, E.H.; Barber, B.; Gell, M. [Univ. of Connecticut, Storrs, CT (United States)

    1998-10-09

    Elastic-plastic finite element models are used to define the thermal/residual stress state responsible for the observed failure behavior of an electron beam physical vapor deposited yttria stabilized zirconia thermal barrier coating on a Pt-Al bond coat. The failures were observed to start at grain boundary ridges, some of which evolved into oxide filled cavities. Finite element models are made of the actual interface geometries through the use of metallographic sectioning and imaging processing. There is a one to one correspondence of calculated tension in the oxide layer and the observed localized damage. Purely elastic analysis failed to show some important tensile regions associated with the observed failure.

  10. Formation of white-eye pattern with microdischarge in an air dielectric barrier discharge system

    CERN Document Server

    He, Yafeng; Liu, Weili; Wang, Hongfang; Zhao, Zengchao; Fan, Weili

    2011-01-01

    We report on the first observation of white-eye pattern in an air dielectric barrier discharge. The patterned discharges undergo a development as following: random spots - quasihexagonal pattern - hexagonal pattern (type I) - hexagonal pattern (type II) - white-eye pattern - chaos as the voltage is increased. The spatiotemporal characteristics of patterned discharges are investigated by using an optical method. Results show that the two discharge modes, uniform mode and filamentary mode, are actually two different spatial presentations of the same origin: the microdischarge. From the viewpoint of pattern dynamics, the white-eye pattern results from a 3-wave resonance interaction.

  11. Ultrasound-mediated blood-brain barrier disruption for targeted drug delivery in the central nervous system

    Science.gov (United States)

    McDannold, Nathan; Zhang, Yongzhi; Power, Chanikarn; Arvanitis, Costas D.; Vykhodtseva, Natalia; Livingstone, Margaret

    2015-05-01

    The physiology of the vasculature in the central nervous system (CNS), which includes the blood-brain barrier (BBB) and other factors, complicates the delivery of most drugs to the brain. Different methods have been used to bypass the BBB, but they have limitations such as being invasive, non-targeted or requiring the formulation of new drugs. Focused ultrasound (FUS), when combined with circulating microbubbles, is a noninvasive method to locally and transiently disrupt the BBB at discrete targets. The method presents new opportunities for the use of drugs and for the study of the brain.

  12. [Vascular endothelial Barrier Function].

    Science.gov (United States)

    Ivanov, A N; Puchinyan, D M; Norkin, I A

    2015-01-01

    Endothelium is an important regulator of selective permeability of the vascular wall for different molecules and cells. This review summarizes current data on endothelial barrier function. Endothelial glycocalyx structure, its function and role in the molecular transport and leukocytes migration across the endothelial barrier are discussed. The mechanisms of transcellular transport of macromolecules and cell migration through endothelial cells are reviewed. Special section of this article addresses the structure and function of tight and adherens endothelial junction, as well as their importance for the regulation of paracellular transport across the endothelial barrier. Particular attention is paid to the signaling mechanism of endothelial barrier function regulation and the factors that influence on the vascular permeability.

  13. Self-incompatibility systems: barriers to self-fertilization in flowering plants.

    Science.gov (United States)

    Rea, Anne C; Nasrallah, June B

    2008-01-01

    Flowering plants (angiosperms) are the most prevalent and evolutionarily advanced group of plants. Success of these plants is owed to several unique evolutionary adaptations that aid in reproduction: the flower, the closed carpel, double fertilization, and the ultimate products of fertilization, seeds enclosed in the fruit. Angiosperms exhibit a vast array of reproductive strategies, including both asexual and sexual, the latter of which includes both self-fertilization and cross-fertilization. Asexual reproduction and self-fertilization are important reproductive strategies in a variety of situations, such as when mates are scarce or when the environment remains relatively stable. However, reproductive strategies promoting cross-fertilization are critical to angiosperm success, since they contribute to the creation of genetically diverse populations, which increase the probability that at least one individual in a population will survive given changing environmental conditions. The evolution of several physical and genetic barriers to self-fertilization or fertilization among closely related individuals is thus widespread in angiosperms. A major genetic barrier to self-fertilization is self-incompatibility (SI), which allows female reproductive cells to discriminate between "self" and "non-self" pollen, and specifically reject self pollen. Evidence for the importance of SI in angiosperm evolution lies in the highly diverse set of mechanisms used by various angiosperm families for recognition of self pollen tube development and preventing self-fertilization.

  14. Design of an operations manager selection system in service encounter

    Directory of Open Access Journals (Sweden)

    Tanawin Nunthaphanich

    2015-10-01

    Full Text Available The purpose of this study is to provide criteria for selecting operations managers at the ‘service encounter’ for mobile telecommunication companies, and develop a system for this multi-criteria decision-making scheme based on the Analytical Hierarchy Process (AHP. There are three main criteria for evaluating the capability of service-encounter operation managers: (1 the ability to design service process; (2 the ability to operate service process; (3 the ability to conduct improvement. The AHP operation manager selection tool was developed based on the complex problems at the service encounter. It was created as a decision support system which was used to recruit and evaluate operations managers’ capability for the purpose of career advancement.

  15. Soybean cultivar selection for Bioregenerative Life Support Systems (BLSS) - Theoretical selection

    Science.gov (United States)

    De Micco, Veronica; Buonomo, Roberta; Paradiso, Roberta; De Pascale, Stefania; Aronne, Giovanna

    2012-05-01

    The development of plant-based Bioregenerative Life Support Systems (BLSS) is a requirement for the realization of long-duration exploratory-class manned missions in so far as they help fulfilling astronauts' needs including nutritional demands, air regeneration and psychological support. The program ESA - MELiSSA (European Space Agency - Micro-Ecological Life Support System Alternative) aims to conceive an artificial bioregenerative ecosystem based on both microorganisms and higher plants. Soybean is one of the four crops studied within this program as a candidate for cultivation in forthcoming BLSS. Within this project, the aim of this study was to develop a methodology for the selection of soybean candidate cultivars for BLSS. Our scope was to identify an objective and repeatable procedure to choose the best cultivar at each time, overcoming the variability of the market supply. This purpose was pursued with an approach based on a two-steps procedure: (a) the development of an objective criterion for the selection of the most suitable soybean cultivars (cultivated varieties) based on theoretical considerations and (b) the behaviour evaluation of the 4 best cultivars with a cultivation trial in a controlled environment. In this paper, we report the first phase of the selection procedure. We started with a literature survey to look for data about environmental needs, potential yields and nutritional traits of soybean cultivars already tested in cultivation trials (disregarding Gene Modified Organisms). Afterwards, a preliminary screening based on information about the main European companies and the most commercialized cultivars, as well as on the criteria suggested by ESA, allowed to select 93 cultivars among the 297 admitted in EU. Finally, an algorithm, based on the relevance of each considered characteristic, was created to attribute a score to each cultivar and to rank it for the identification of the best cultivars for subsequent cultivation trials.

  16. Determination of selectivity of HPLC systems by correspondence factor analysis

    Institute of Scientific and Technical Information of China (English)

    Yuan Wang; Jun Yang; Xin Lu; Guo Wang Xu

    2007-01-01

    Correspondence factor analysis (CFA) was employed to study the selectivity of 14 HPLC systems, The tested LC systems were classified as reversed-phase (RP), ion-exchange (IE) and hydrophilic interaction chromatography (HILIC) modes. It was found that the retentions of the hydrophilic solutes on HILIC column were significantly influenced by the second-order effects besides their hydrophilic properties. Organic modifiers and residue silanol groups on silica surface both participated in retention. HypersilTM amino column performed separation in the HILIC mode at appropriate conditions, and its retention mechanism was more similar to that of HILIC silica column than that of HILIC column coating poly(aspartamide) groups.

  17. Material Design, Selection, and Manufacturing Methods for System Sustainment

    Energy Technology Data Exchange (ETDEWEB)

    David Sowder, Jim Lula, Curtis Marshall

    2010-02-18

    This paper describes a material selection and validation process proven to be successful for manufacturing high-reliability long-life product. The National Secure Manufacturing Center business unit of the Kansas City Plant (herein called KCP) designs and manufactures complex electrical and mechanical components used in extreme environments. The material manufacturing heritage is founded in the systems design to manufacturing practices that support the U.S. Department of Energy’s National Nuclear Security Administration (DOE/NNSA). Material Engineers at KCP work with the systems designers to recommend materials, develop test methods, perform analytical analysis of test data, define cradle to grave needs, present final selection and fielding. The KCP material engineers typically will maintain cost control by utilizing commercial products when possible, but have the resources and to develop and produce unique formulations as necessary. This approach is currently being used to mature technologies to manufacture materials with improved characteristics using nano-composite filler materials that will enhance system design and production. For some products the engineers plan and carry out science-based life-cycle material surveillance processes. Recent examples of the approach include refurbished manufacturing of the high voltage power supplies for cockpit displays in operational aircraft; dry film lubricant application to improve bearing life for guided munitions gyroscope gimbals, ceramic substrate design for electrical circuit manufacturing, and tailored polymeric materials for various systems. The following examples show evidence of KCP concurrent design-to-manufacturing techniques used to achieve system solutions that satisfy or exceed demanding requirements.

  18. Cultural selection drives the evolution of human communication systems.

    Science.gov (United States)

    Tamariz, Monica; Ellison, T Mark; Barr, Dale J; Fay, Nicolas

    2014-08-07

    Human communication systems evolve culturally, but the evolutionary mechanisms that drive this evolution are not well understood. Against a baseline that communication variants spread in a population following neutral evolutionary dynamics (also known as drift models), we tested the role of two cultural selection models: coordination- and content-biased. We constructed a parametrized mixed probabilistic model of the spread of communicative variants in four 8-person laboratory micro-societies engaged in a simple communication game. We found that selectionist models, working in combination, explain the majority of the empirical data. The best-fitting parameter setting includes an egocentric bias and a content bias, suggesting that participants retained their own previously used communicative variants unless they encountered a superior (content-biased) variant, in which case it was adopted. This novel pattern of results suggests that (i) a theory of the cultural evolution of human communication systems must integrate selectionist models and (ii) human communication systems are functionally adaptive complex systems.

  19. Robust nonlinear variable selective control for networked systems

    Science.gov (United States)

    Rahmani, Behrooz

    2016-10-01

    This paper is concerned with the networked control of a class of uncertain nonlinear systems. In this way, Takagi-Sugeno (T-S) fuzzy modelling is used to extend the previously proposed variable selective control (VSC) methodology to nonlinear systems. This extension is based upon the decomposition of the nonlinear system to a set of fuzzy-blended locally linearised subsystems and further application of the VSC methodology to each subsystem. To increase the applicability of the T-S approach for uncertain nonlinear networked control systems, this study considers the asynchronous premise variables in the plant and the controller, and then introduces a robust stability analysis and control synthesis. The resulting optimal switching-fuzzy controller provides a minimum guaranteed cost on an H2 performance index. Simulation studies on three nonlinear benchmark problems demonstrate the effectiveness of the proposed method.

  20. Acanthamoeba produces disseminated infection in locusts and traverses the locust blood-brain barrier to invade the central nervous system

    Directory of Open Access Journals (Sweden)

    Kirk Ruth

    2010-07-01

    Full Text Available Abstract Background Many aspects of Acanthamoeba granulomatous encephalitis remain poorly understood, including host susceptibility and chronic colonization which represent important features of the spectrum of host-pathogen interactions. Previous studies have suggested locusts as a tractable model in which to study Acanthamoeba pathogenesis. Here we determined the mode of parasite invasion of the central nervous system (CNS. Results Using Acanthamoeba isolates belonging to the T1 and T4 genotypes, the findings revealed that amoebae induced sickness behaviour in locusts, as evidenced by reduced faecal output and weight loss and, eventually, leading to 100% mortality. Significant degenerative changes of various tissues were observed by histological sectioning. Both isolates produced disseminated infection, with viable amoebae being recovered from various tissues. Histological examination of the CNS showed that Acanthamoeba invaded the locust CNS, and this is associated with disruption of the perineurium cell/glial cell complex, which constitutes the locust blood-brain barrier. Conclusions This is the first study to demonstrate that Acanthamoeba invades locust brain by modulating the integrity of the insect's blood-brain barrier, a finding that is consistent with the human infection. These observations support the idea that locusts provide a tractable model to study Acanthamoeba encephalitis in vivo. In this way the locust model may generate potentially useful leads that can be tested subsequently in mammalian systems, thus replacing the use of vertebrates at an early stage, and reducing the numbers of mammals required overall.

  1. Geophysical characterization of subsurface barriers

    Energy Technology Data Exchange (ETDEWEB)

    Borns, D.J.

    1995-08-01

    An option for controlling contaminant migration from plumes and buried waste sites is to construct a subsurface barrier of a low-permeability material. The successful application of subsurface barriers requires processes to verify the emplacement and effectiveness of barrier and to monitor the performance of a barrier after emplacement. Non destructive and remote sensing techniques, such as geophysical methods, are possible technologies to address these needs. The changes in mechanical, hydrologic and chemical properties associated with the emplacement of an engineered barrier will affect geophysical properties such a seismic velocity, electrical conductivity, and dielectric constant. Also, the barrier, once emplaced and interacting with the in situ geologic system, may affect the paths along which electrical current flows in the subsurface. These changes in properties and processes facilitate the detection and monitoring of the barrier. The approaches to characterizing and monitoring engineered barriers can be divided between (1) methods that directly image the barrier using the contrasts in physical properties between the barrier and the host soil or rock and (2) methods that reflect flow processes around or through the barrier. For example, seismic methods that delineate the changes in density and stiffness associated with the barrier represents a direct imaging method. Electrical self potential methods and flow probes based on heat flow methods represent techniques that can delineate the flow path or flow processes around and through a barrier.

  2. Rule-based Expert Systems for Selecting Information Systems Development Methodologies

    Directory of Open Access Journals (Sweden)

    Abdel Nasser H. Zaied

    2013-08-01

    Full Text Available Information Systems (IS are increasingly becoming regarded as crucial to an organization's success. Information Systems Development Methodologies (ISDMs are used by organizations to structure the information system development process. ISDMs are essential for structuring project participants’ thinking and actions; therefore ISDMs play an important role to achieve successful projects. There are different ISDMs and no methodology can claim that it can be applied to any organization. The problem facing decision makers is how to select an appropriate development methodology that may increase the probability of system success. This paper takes this issue into account when study ISDMs and provides a Rule-based Expert System as a tool for selecting appropriate ISDMs. The proposed expert system consists of three main phases to automate the process of selecting ISDMs.Three approaches were used to test the proposed expert system. Face validation through six professors and six IS professionals, predictive validation through twenty four experts and blind validation through nine employees working in IT field.The results show that the proposed system was found to be run without any errors, offered a friendly user interface and its suggestions matching user expectations with 95.8%. It also can help project managers, systems' engineers, systems' developers, consultants, and planners in the process of selecting the suitable ISDM. Finally, the results show that the proposed Rule-based Expert System can facilities the selection process especially for new users and non-specialist in Information System field.

  3. Texas Barrier Islands Region ecological characterization: environmental synthesis papers

    Energy Technology Data Exchange (ETDEWEB)

    Shew, D.M.; Baumann, R.H.; Fritts, T.H.; Dunn, L.S.

    1981-09-01

    This report is a synthesis of selected environmental literature for the Texas Barrier Islands Region and is a part of the Texas Barrier Islands Region Ecological Characterization Study. The Texas Barrier Islands Region is defined to include the coastal counties and extends 64 km inland and offshore to the State-Federal demarcation. These papers deal with six drainage basins along the Texas coast: Galveston, Matagorda-Brazos, San Antonio, Copano-Aransas, Corpus Christi and Laguna Madre; as well as the marine system offshore. The papers address the geology, climate, hydrology and hydrography, and the biology of each basin.

  4. Model selection in systems biology depends on experimental design.

    Science.gov (United States)

    Silk, Daniel; Kirk, Paul D W; Barnes, Chris P; Toni, Tina; Stumpf, Michael P H

    2014-06-01

    Experimental design attempts to maximise the information available for modelling tasks. An optimal experiment allows the inferred models or parameters to be chosen with the highest expected degree of confidence. If the true system is faithfully reproduced by one of the models, the merit of this approach is clear - we simply wish to identify it and the true parameters with the most certainty. However, in the more realistic situation where all models are incorrect or incomplete, the interpretation of model selection outcomes and the role of experimental design needs to be examined more carefully. Using a novel experimental design and model selection framework for stochastic state-space models, we perform high-throughput in-silico analyses on families of gene regulatory cascade models, to show that the selected model can depend on the experiment performed. We observe that experimental design thus makes confidence a criterion for model choice, but that this does not necessarily correlate with a model's predictive power or correctness. Finally, in the special case of linear ordinary differential equation (ODE) models, we explore how wrong a model has to be before it influences the conclusions of a model selection analysis.

  5. BiOSS: A system for biomedical ontology selection.

    Science.gov (United States)

    Martínez-Romero, Marcos; Vázquez-Naya, José M; Pereira, Javier; Pazos, Alejandro

    2014-04-01

    In biomedical informatics, ontologies are considered a key technology for annotating, retrieving and sharing the huge volume of publicly available data. Due to the increasing amount, complexity and variety of existing biomedical ontologies, choosing the ones to be used in a semantic annotation problem or to design a specific application is a difficult task. As a consequence, the design of approaches and tools addressed to facilitate the selection of biomedical ontologies is becoming a priority. In this paper we present BiOSS, a novel system for the selection of biomedical ontologies. BiOSS evaluates the adequacy of an ontology to a given domain according to three different criteria: (1) the extent to which the ontology covers the domain; (2) the semantic richness of the ontology in the domain; (3) the popularity of the ontology in the biomedical community. BiOSS has been applied to 5 representative problems of ontology selection. It also has been compared to existing methods and tools. Results are promising and show the usefulness of BiOSS to solve real-world ontology selection problems. BiOSS is openly available both as a web tool and a web service.

  6. Assessing the performance of a permeable reactive barrier-aquifer system using a dual-domain solute transport model

    Science.gov (United States)

    Chen, Jui-Sheng; Hsu, Shao-Yiu; Li, Ming-Hsu; Liu, Chen-Wuing

    2016-12-01

    Transport behavior through a permeable reactive barrier (PRB)-aquifer system is complicated because of the different physical and chemical properties of the PRB and the aquifer. Dual-domain solute transport models are efficient tools for better understanding the various processes and mechanisms of reactive solute transport through a PRB-aquifer system. This study develops a dual-domain analytical model to assess the physical and chemical processes of two-dimensional reactive solute transport through a PRB-aquifer system. The dispersion processes of a dual-domain system on the solute transport are investigated. The results show that the dispersion parameters in a dual-domain system synchronously govern the dynamic shape of the contaminant plume. The low longitudinal and transverse dispersion coefficients of a dual-domain system may restrict the spreading of the plume and elevate the plume's concentration level. The derived analytical solution is applied to explore how the different reactive transport processes affect the performance of a PRB-aquifer system. The results show that the first-order decay rate constant of the PRB has a critical effect on the performance of the PRB-aquifer system, whereas the effects of the physical dispersion properties on PRB performance are less significant.

  7. Development Status and Performance Comparisons of Environmental Barrier Coating Systems for SiCSiC Ceramic Matrix Composites

    Science.gov (United States)

    Zhu, Dongming; Harder, Bryan

    2016-01-01

    Environmental barrier coatings (EBC) and SiCSiC ceramic matrix composites (CMCs) will play a crucial role in future aircraft turbine engine systems, because of their ability to significantly increase engine operating temperatures, reduce engine weight and cooling requirements. This paper presents current NASA EBC-CMC development emphases including: the coating composition and processing improvements, laser high heat flux-thermal gradient thermo-mechanical fatigue - environmental testing methodology development, and property evaluations for next generation EBC-CMC systems. EBCs processed with various deposition techniques including Plasma Spray, Electron Beam - Physical Vapor Deposition, and Plasma Spray Physical Vapor Deposition (PS-PVD) will be particularly discussed. The testing results and demonstrations of advanced EBCs-CMCs in complex simulated engine thermal gradient cyclic fatigue, oxidizing-steam and CMAS environments will help provide insights into the coating development strategies to meet long-term engine component durability goals.

  8. Selective transmission and channel estimation in massive MIMO systems

    Institute of Scientific and Technical Information of China (English)

    杨睿哲

    2016-01-01

    Massive MIMO systems have got extraordinary spectral efficiency using a large number of base station antennas, but it is in the challenge of pilot contamination using the aligned pilots.To address this issue, a selective transmission is proposed using time-shifted pilots with cell grouping, where the strong interfering users in downlink transmission cells are temporally stopped during the pilots transmission in uplink cells.Based on the spatial characteristics of physical channel models, the strong interfering users are selected to minimize the inter-cell interference and the cell grouping is designed to have less temporally stopped users within a smaller area.Furthermore, a Kalman estima-tor is proposed to reduce the unexpected effect of residual interferences in channel estimation, which exploits both the spatial-time correlation of channels and the share of the interference information. The numerical results show that our scheme significantly improves the channel estimation accuracy and the data rates.

  9. Maximum MIMO System Mutual Information with Antenna Selection and Interference

    Directory of Open Access Journals (Sweden)

    Rick S. Blum

    2004-05-01

    Full Text Available Maximum system mutual information is considered for a group of interfering users employing single user detection and antenna selection of multiple transmit and receive antennas for flat Rayleigh fading channels with independent fading coefficients for each path. In the case considered, the only feedback of channel state information to the transmitter is that required for antenna selection, but channel state information is assumed at the receiver. The focus is on extreme cases with very weak interference or very strong interference. It is shown that the optimum signaling covariance matrix is sometimes different from the standard scaled identity matrix. In fact, this is true even for cases without interference if SNR is sufficiently weak. Further, the scaled identity matrix is actually that covariance matrix that yields worst performance if the interference is sufficiently strong.

  10. Perceived barriers of heart failure nurses and cardiologists in using clinical decision support systems in the treatment of heart failure patients

    Science.gov (United States)

    2013-01-01

    Background Clinical Decision Support Systems (CDSSs) can support guideline adherence in heart failure (HF) patients. However, the use of CDSSs is limited and barriers in working with CDSSs have been described as a major obstacle. It is unknown if barriers to CDSSs are present and differ between HF nurses and cardiologists. Therefore the aims of this study are; 1. Explore the type and number of perceived barriers of HF nurses and cardiologists to use a CDSS in the treatment of HF patients. 2. Explore possible differences in perceived barriers between two groups. 3. Assess the relevance and influence of knowledge management (KM) on Responsibility/Trust (R&T) and Barriers/Threats (B&T). Methods A questionnaire was developed including; B&T, R&T, and KM. For analyses, descriptive techniques, 2-tailed Pearson correlation tests, and multiple regression analyses were performed. Results The response- rate of 220 questionnaires was 74%. Barriers were found for cardiologists and HF nurses in all the constructs. Sixty-five percent did not want to be dependent on a CDSS. Nevertheless thirty-six percent of HF nurses and 50% of cardiologists stated that a CDSS can optimize HF medication. No relationship between constructs and age; gender; years of work experience; general computer experience and email/internet were observed. In the group of HF nurses a positive correlation (r .33, PKM was associated with the constructs B&T (B=.55, P=barriers in working with a CDSS in all of the examined constructs. KM has a strong positive correlation with perceived barriers, indicating that increasing knowledge about CDSSs can decrease their barriers. PMID:23622342

  11. Classification systems and selection systems: the risks of radical innovation and category spanning

    NARCIS (Netherlands)

    Wijnberg, N.M.

    2011-01-01

    This paper looks at the relations between classification and competition, using the theoretical framework of selection system theory. In a particular competitive arena more than one classification system can be in use. The proportion of classification systems in use by consumers that are also in use

  12. Origin of the Energy Barrier to Chemical Reactions of O2 on Al(111): Evidence for Charge Transfer, Not Spin Selection

    Science.gov (United States)

    2012-11-08

    change of O2 spin, at the barrier [Fig. 3]; i.e., the corresponding diabatic surfaces cross. Far from the Al surface, the triplet state is...previous theoretical models, in particular nonadiabatic [17] or diabatic [16] approaches, which also find an energy barrier consistent with experiment...crossings of different diabatic O2 spin configuration sur- faces are accommodated by small spin fluctuations within the metal surface. For parallel

  13. Load rate dependence of the mechanical properties of thermal barrier coating systems

    Energy Technology Data Exchange (ETDEWEB)

    Zotov, Nikolay; Eggeler, Gunther [Institut fuer Werkstoffe, Ruhr Universitaet Bochum, 44780 Bochum (Germany); Bartsch, Marion [Institut fuer Werkstoff-Forschung, DLR Koeln, 51147 Koeln (Germany)

    2009-07-01

    Thermal barrier coatings (TBC), composed of yttrium-stabilized zirconia (YSZ) ceramic top coat (TC) and intermetallic NiCoCrAlY bond coat (BC) are commonly used as protective coatings of Ni-based high temperature gas engine components. Nanoindentation techniques are increasingly applied for determining the TBC mechanical properties on a nanometre scale. However, little is known about the load-rate dependence of the mechanical properties, which is important for better understanding of cyclic thermal fatigue experiments. Nanoindentations with different load rates omega were performed on polished cross-sections of TBC, deposited by EB-PVD on IN625 substrates (S), using a XP Nanoindenter (MTS) equipped with Berkovich diamond tip. The Young's modulus (E) of the TC is independent of omega, while E for the BC and the S decreases with omega. The hardness (H) of the TC and the BC increases, while H for the S decreases with omega. From the dependence of H on omega, creep power-law exponents c = 0.24(11) and c = 0.023(6) for the TC and the BC were determined. For all TBC components, a decrease with omega of the power-law exponents n and m, describing the loading and unloading nanoindentation curves, is observed.

  14. Distributive estimation of frequency selective channels for massive MIMO systems

    KAUST Repository

    Zaib, Alam

    2015-12-28

    We consider frequency selective channel estimation in the uplink of massive MIMO-OFDM systems, where our major concern is complexity. A low complexity distributed LMMSE algorithm is proposed that attains near optimal channel impulse response (CIR) estimates from noisy observations at receive antenna array. In proposed method, every antenna estimates the CIRs of its neighborhood followed by recursive sharing of estimates with immediate neighbors. At each step, every antenna calculates the weighted average of shared estimates which converges to near optimal LMMSE solution. The simulation results validate the near optimal performance of proposed algorithm in terms of mean square error (MSE). © 2015 EURASIP.

  15. Blood-Brain Barrier Disruption and Oxidative Stress in Guinea Pig after Systemic Exposure to Modified Cell-Free Hemoglobin

    Science.gov (United States)

    Butt, Omer I.; Buehler, Paul W.; D'Agnillo, Felice

    2011-01-01

    Systemic exposure to cell-free hemoglobin (Hb) or its breakdown products after hemolysis or with the use of Hb-based oxygen therapeutics may alter the function and integrity of the blood-brain barrier. Using a guinea pig exchange transfusion model, we investigated the effect of a polymerized cell-free Hb (HbG) on the expression of endothelial tight junction proteins (zonula occludens 1, claudin-5, and occludin), astrocyte activation, IgG extravasation, heme oxygenase (HO), iron deposition, oxidative end products (4-hydroxynonenal adducts and 8-hydroxydeoxyguanosine), and apoptosis (cleaved caspase 3). Reduced zonula occludens 1 expression was observed after HbG transfusion as evidenced by Western blot and confocal microscopy. Claudin-5 distribution was altered in small- to medium-sized vessels. However, total expression of claudin-5 and occludin remained unchanged except for a notable increase in occludin 72 hours after HbG transfusion. HbG-transfused animals also showed increased astrocytic glial fibrillary acidic protein expression and IgG extravasation after 72 hours. Increased HO activity and HO-1 expression with prominent enhancement of HO-1 immunoreactivity in CD163-expressing perivascular cells and infiltrating monocytes/macrophages were also observed. Consistent with oxidative stress, HbG increased iron deposition, 4-hydroxynonenal and 8-hydroxydeoxyguanosine immunoreactivity, and cleaved caspase-3 expression. Systemic exposure to an extracellular Hb triggers blood-brain barrier disruption and oxidative stress, which may have important implications for the use of Hb-based therapeutics and may provide indirect insight on the central nervous system vasculopathies associated with excessive hemolysis. PMID:21356382

  16. Materials selection guidelines for geothermal energy utilization systems

    Energy Technology Data Exchange (ETDEWEB)

    Ellis, P.F. II; Conover, M.F.

    1981-01-01

    This manual includes geothermal fluid chemistry, corrosion test data, and materials operating experience. Systems using geothermal energy in El Salvador, Iceland, Italy, Japan, Mexico, New Zealand, and the United States are described. The manual provides materials selection guidelines for surface equipment of future geothermal energy systems. The key chemical species that are significant in determining corrosiveness of geothermal fluids are identified. The utilization modes of geothermal energy are defined as well as the various physical fluid parameters that affect corrosiveness. Both detailed and summarized results of materials performance tests and applicable operating experiences from forty sites throughout the world are presented. The application of various non-metal materials in geothermal environments are discussed. Included in appendices are: corrosion behavior of specific alloy classes in geothermal fluids, corrosion in seawater desalination plants, worldwide geothermal power production, DOE-sponsored utilization projects, plant availability, relative costs of alloys, and composition of alloys. (MHR)

  17. System Quality Characteristics for Selecting Mobile Learning Applications

    Directory of Open Access Journals (Sweden)

    Mohamed SARRAB

    2015-10-01

    Full Text Available The majority of M-learning (Mobile learning applications available today are developed for the formal learning and education environment. These applications are characterized by the improvement in the interaction between learners and instructors to provide high interaction and flexibility to the learning process. M-learning is gaining increased recognition and adoption by different organizations. With the high number of M-learning applications available today, making the right decision about which, application to choose can be quite challenging. To date there is no complete and well defined set of system characteristics for such M-learning applications. This paper presents system quality characteristics for selecting M-learning applications based on the result of a systematic review conducted in this domain.

  18. Selecting, adapting, and sustaining programs in health care systems

    Directory of Open Access Journals (Sweden)

    Zullig LL

    2015-04-01

    Full Text Available Leah L Zullig,1,2 Hayden B Bosworth1–4 1Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC, USA; 2Department of Medicine, Duke University Medical Center, Durham, NC, USA; 3School of Nursing, 4Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA Abstract: Practitioners and researchers often design behavioral programs that are effective for a specific population or problem. Despite their success in a controlled setting, relatively few programs are scaled up and implemented in health care systems. Planning for scale-up is a critical, yet often overlooked, element in the process of program design. Equally as important is understanding how to select a program that has already been developed, and adapt and implement the program to meet specific organizational goals. This adaptation and implementation requires attention to organizational goals, available resources, and program cost. We assert that translational behavioral medicine necessitates expanding successful programs beyond a stand-alone research study. This paper describes key factors to consider when selecting, adapting, and sustaining programs for scale-up in large health care systems and applies the Knowledge to Action (KTA Framework to a case study, illustrating knowledge creation and an action cycle of implementation and evaluation activities. Keywords: program sustainability, diffusion of innovation, information dissemination, health services research, intervention studies 

  19. Interference-aware random beam selection for spectrum sharing systems

    KAUST Repository

    Abdallah, Mohamed M.

    2012-09-01

    Spectrum sharing systems have been introduced to alleviate the problem of spectrum scarcity by allowing secondary unlicensed networks to share the spectrum with primary licensed networks under acceptable interference levels to the primary users. In this paper, we develop interference-aware random beam selection schemes that provide enhanced throughput for the secondary link under the condition that the interference observed at the primary link is within a predetermined acceptable value. For a secondary transmitter equipped with multiple antennas, our schemes select a random beam, among a set of power- optimized orthogonal random beams, that maximizes the capacity of the secondary link while satisfying the interference constraint at the primary receiver for different levels of feedback information describing the interference level at the primary receiver. For the proposed schemes, we develop a statistical analysis for the signal-to-noise and interference ratio (SINR) statistics as well as the capacity of the secondary link. Finally, we present numerical results that study the effect of system parameters including number of beams and the maximum transmission power on the capacity of the secondary link attained using the proposed schemes. © 2012 IEEE.

  20. Multicriteria analysis in selecting the optimal variant of solar system

    Directory of Open Access Journals (Sweden)

    Radziejowska Aleksandra

    2016-01-01

    Full Text Available Alternative energy sources are becoming more serious competition to traditional ways of generating energy. It becomes real integration of eco-energy with ecology, as well as the innovative technologies with low-energy construction. Apart from the cost an important issue are technical parameters of the equipment, durability, ease of installation, etc. The investor therefore is facing with the problem of decision-making to choose the best solution from the point of view of many criteria. In the article, the authors present the proposal to apply the methods of multi-criteria analysis to select the most beneficial variant of the solar system solutions. In this purpose will be use among other method: multivariate analysis of Saaty’s AHP, the taxonomic method of weighting factors and, belonging to a group of methods using outranking relations, the Promethee II method. Proposed comparative analysis can be used as a method for decision support during the selection of the most beneficial technological solution of solar installation and to evaluate operational efficiency existing buildings which will have implemented new systems.

  1. Benefits and Barriers of Implementation and Utilization of Radio-Frequency Identification (RFID) Systems in Transfusion Medicine.

    Science.gov (United States)

    Coustasse, Alberto; Cunningham, Brian; Deslich, Stacie; Willson, Eric; Meadows, Pamela

    2015-01-01

    Radio-frequency identification (RFID) technology is used by hospital supply chains to track medical products and monitor inventories. Hospitals have also begun incorporating RFID technology as part of their transfusion processes. The purpose of this review was to analyze how healthcare organization supply chains can benefit from the utilization of RFID systems in transfusion service departments. The methodology for this study was a literature review following the steps of a systematic review with a total of 52 sources referenced. RFID technology is used to manage and track blood products from the initial donor phlebotomy to final disposition or product transfusion. RFID-enabled transfusion practices have successfully increased provider productivity and product quality through work-time reduction and error reduction. Findings of this research study suggest that RFID has provided improvements in quality of care and efficiency, while initial costs, security, and privacy appear to be the principal barriers to adoption.

  2. Effect of Residual Stresses and Prediction of Possible Failure Mechanisms on Thermal Barrier Coating System by Finite Element Method

    Science.gov (United States)

    Ranjbar-Far, M.; Absi, J.; Mariaux, G.; Shahidi, S.

    2010-09-01

    This work is focused on the effect of the residual stresses resulting from the coating process and thermal cycling on the failure mechanisms within the thermal barrier coating (TBC) system. To reach this objective, we studied the effect of the substrate preheating and cooling rate on the coating process conditions. A new thermomechanical finite element model (FEM) considering a nonhomogeneous temperature distribution has been developed. In the results, we observed a critical stress corresponding to a low substrate temperature and high cooling rate during spraying of the top-coat material. Moreover, the analysis of the stress distribution after service shows that more critical stresses are obtained in the case where residual stresses are taken into account.

  3. Barriers to control syphilis and HIV vertical transmission in the health care system in the city of Sao Paulo

    Directory of Open Access Journals (Sweden)

    Valdete Maria Ramos

    2014-12-01

    Full Text Available OBJECTIVE: The objective of this study was to identify possible barriers to control vertical transmission of syphilis and HIV through the analysis of the orientation process of pregnant women from prenatal care to the obstetric center at an university hospital in Sao Paulo (Reference and their return (with their exposed babies for follow-up after hospital discharge (counter-reference. METHODS: It is a retrospective cross-sectional study including interviews with healthcare personnel. Pregnant women with syphilis and/or HIV-infection admitted for labor or miscarriage were identified from August 2006 to August 2007. Routine care for mothers and babies were analyzed. RESULTS: 56 pregnant women were identified: 43 were HIV-infected, 11 had syphilis and two were coinfected (syphilis/HIV; 22 health care professionals were interviewed. Prenatal care was identified in 91.1% of these women: 7/11 (63.6% with syphilis; 44/45 (97.8% HIV-infected or coinfected. The reference for delivery was satisfactory for 57.7% of the syphilis-infected women and 97.7% of the HIV-infected ones. The counter-reference was satisfactory for all babies and mothers at hospital discharge, besides the non-adherence to this recommendation. Interviews with health care professionals showed there are better routines for assisting and following-up pregnant women, puerperal women and HIV-infected or exposed babies than for those infected with syphilis. The epidemiological report and surveillance system are also better for HIV-infected patients. CONCLUSION: The difficulties in the reference and counter-reference system of these women and their babies are evident barriers to control the vertical transmission of these infectious diseases.

  4. Integrated geological-engineering model of Patrick Draw field and examples of similarities and differences among various shoreline barrier systems

    Energy Technology Data Exchange (ETDEWEB)

    Schatzinger, R.A.; Szpakiewicz, M.J.; Jackson, S.R.; Chang, M.M.; Sharma, B.; Tham, M.K.; Cheng, A.M.

    1992-04-01

    The Reservoir Assessment and Characterization Research Program at NIPER employs an interdisciplinary approach that focuses on the high priority reservoir class of shoreline barrier deposits to: (1) determine the problems specific to this class of reservoirs by identifying the reservoir heterogeneities that influence the movement and trapping of fluids; and (2) develop methods to characterize effectively this class of reservoirs to predict residual oil saturation (ROS) on interwell scales and improve prediction of the flow patterns of injected and produced fluids. Accurate descriptions of the spatial distribution of critical reservoir parameters (e.g., permeability, porosity, pore geometry, mineralogy, and oil saturation) are essential for designing and implementing processes to improve sweep efficiency and thereby increase oil recovery. The methodologies and models developed in this program will, in the near- to mid-term, assist producers in the implementation of effective reservoir management strategies such as location of infill wells and selection of optimum enhanced oil recovery methods to maximize oil production from their reservoirs.

  5. HYBRID FEATURE SELECTION ALGORITHM FOR INTRUSION DETECTION SYSTEM

    Directory of Open Access Journals (Sweden)

    Seyed Reza Hasani

    2014-01-01

    Full Text Available Network security is a serious global concern. Usefulness Intrusion Detection Systems (IDS are increasing incredibly in Information Security research using Soft computing techniques. In the previous researches having irrelevant and redundant features are recognized causes of increasing the processing speed of evaluating the known intrusive patterns. In addition, an efficient feature selection method eliminates dimension of data and reduce redundancy and ambiguity caused by none important attributes. Therefore, feature selection methods are well-known methods to overcome this problem. There are various approaches being utilized in intrusion detections, they are able to perform their method and relatively they are achieved with some improvements. This work is based on the enhancement of the highest Detection Rate (DR algorithm which is Linear Genetic Programming (LGP reducing the False Alarm Rate (FAR incorporates with Bees Algorithm. Finally, Support Vector Machine (SVM is one of the best candidate solutions to settle IDSs problems. In this study four sample dataset containing 4000 random records are excluded randomly from this dataset for training and testing purposes. Experimental results show that the LGP_BA method improves the accuracy and efficiency compared with the previous related research and the feature subcategory offered by LGP_BA gives a superior representation of data.

  6. Patient- and system-related barriers for the earlier diagnosis of colorectal cancer

    OpenAIRE

    2009-01-01

    Abstract Background A cohort of colorectal cancer (CRC) patients represents an opportunity to study missed opportunities for earlier diagnosis. Primary objective: To study the epidemiology of diagnostic delays and failures to offer/complete CRC screening. Secondary objective: To identify system- and patient-related factors that may contribute to diagnostic delays or failures to offer/complete CRC screening. Methods Setting: Rural Veterans Administration (VA) Healthcare system. Participants: C...

  7. PLANET FORMATION IN STELLAR BINARIES. II. OVERCOMING THE FRAGMENTATION BARRIER IN α CENTAURI AND γ CEPHEI-LIKE SYSTEMS

    Energy Technology Data Exchange (ETDEWEB)

    Rafikov, Roman R.; Silsbee, Kedron, E-mail: rrr@astro.princeton.edu [Department of Astrophysical Sciences, Princeton University, Ivy Lane, Princeton, NJ 08540 (United States)

    2015-01-10

    Planet formation in small-separation (∼20 AU) eccentric binaries such as γ Cephei or α Centauri is believed to be adversely affected by the presence of the stellar companion. Strong dynamical excitation of planetesimals by the eccentric companion can result in collisional destruction (rather than growth) of 1-100 km objects, giving rise to the ''fragmentation barrier'' for planet formation. We revise this issue using a novel description of secular dynamics of planetesimals in binaries, which accounts for the gravity of the eccentric, coplanar protoplanetary disk, as well as gas drag. By studying planetesimal collision outcomes, we show, in contrast to many previous studies, that planetesimal growth and subsequent formation of planets (including gas giants) in AU-scale orbits within ∼20 AU separation binaries may be possible, provided that the protoplanetary disks are massive (≳ 10{sup –2} M {sub ☉}) and only weakly eccentric (disk eccentricity ≲ 0.01). These requirements are compatible with both the existence of massive (several M{sub J} ) planets in γ Cep-like systems and the results of recent simulations of gaseous disks in eccentric binaries. Terrestrial and Neptune-like planets can also form in lower-mass disks at small (sub-AU) radii. We find that the fragmentation barrier is less of a problem in eccentric disks that are apsidally aligned with the binary orbit. Alignment gives rise to special locations, where (1) relative planetesimal velocities are low and (2) the timescale of their drag-induced radial drift is long. This causes planetesimal pileup at such locations in the disk and promotes their growth locally, helping to alleviate the timescale problem for core formation.

  8. Looking for Improvement in Last Planner System: Defining Selection Criteria

    DEFF Research Database (Denmark)

    Lindhard, Søren; Wandahl, Søren

    2013-01-01

    Last Planner System has been critiqued for an inconsistent application of flows. Central for this critique was that the sequence of activities was determined based on only duration and interrelationships. In an attempt to improve the on-site scheduling processes, an in-depth analysis of selection...... criteria was carried out. Six flows are identified as relevant: workforce, material, and machinery which comprise the needed resources and safety, climate conditions, and space which affect the pace of the work. Because of the importance to progress in the workflow, and the on-schedule completeness...... of activities, all six flows need to be systematically controlled. The output of the analysis is a list of recommendations of how to refine the schedules by including the six flows in the Phase Scheduling, Look-Ahead, and Commitment levels....

  9. Field testing of behavioral barriers for fish exclusion at cooling-water intake systems, Central Hudson Gas and Electric Company Roseton Generating Station: Final report

    Energy Technology Data Exchange (ETDEWEB)

    Matousek, J.A.; Wells, A.W.; McGroddy, P.M.

    1988-09-01

    A seasonal field testing program was conducted during 1986 and 1987 to evaluate the effectiveness of behavioral barriers at Central Hudson Gas and Electric Corporations's Roseton Generating Station located in the euryhaline section of the Hudson River. This station was selected as representative of power plants with shoreline riverine/estuarine intake systems. Three commercially available devices (air bubble curtain, pneumatic gun, and underwater strobe light) were tested alone and in combination to determine their effectiveness in reducing impingement. The primary testing method incorporated three or four 6-h impingement collections during each test date, each consisting of two randomly assigned 3-h samples: one was an experimental test with a behavioral device in operation, the other a control test with no device operating. The effectiveness of the devices at excluding fish was determined by comparing impingement data from experimental and control periods. Results of the program do not establish that the deployment of underwater strobe lights, pneumatic guns, an air bubble curtain, or various combinations of the three devices will effectively lower fish impingement at power plants similar in design and location to the Roseton plant. Deterrent effectiveness was found to be species-specific and related to time of day. 51 refs., 67 figs., 72 tabs.

  10. Melioidosis and glanders modulation of the innate immune system: barriers to current and future vaccine approaches.

    Science.gov (United States)

    Aschenbroich, Sophie A; Lafontaine, Eric R; Hogan, Robert J

    2016-09-01

    Burkholderia pseudomallei and Burkholderia mallei are pathogenic bacteria causing fatal infections in animals and humans. Both organisms are classified as Tier 1 Select Agents owing to their highly fatal nature, potential/prior use as bioweapons, severity of disease via respiratory exposure, intrinsic resistance to antibiotics, and lack of a current vaccine. Disease manifestations range from acute septicemia to chronic infection, wherein the facultative intracellular lifestyle of these organisms promotes persistence within a broad range of hosts. This ability to thrive intracellularly is thought to be related to exploitation of host immune response signaling pathways. There are currently considerable gaps in our understanding of the molecular strategies employed by these pathogens to modulate these pathways and evade intracellular killing. A better understanding of the specific molecular basis for dysregulation of host immune responses by these organisms will provide a stronger platform to identify novel vaccine targets and develop effective countermeasures.

  11. 76 FR 27355 - Law Enforcement Vehicular Digital Multimedia Evidence Recording System Selection and Application...

    Science.gov (United States)

    2011-05-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Office of Justice Programs Law Enforcement Vehicular Digital Multimedia Evidence Recording System Selection... public, the ``Law Enforcement Vehicular Digital Multimedia Evidence Recording System Selection...

  12. The efficacy of different moisturizers on barrier recovery in hairless mice evaluated by non-invasive bioengineering methods. A model to select the potentially most effective product

    DEFF Research Database (Denmark)

    Mørtz, Charlotte G; Andersen, Klaus Ejner; Halkier-Sørensen, L

    1997-01-01

    perturbation with acetone. The efficacy was evaluated by measurement of the transepidermal water loss (TEWL) and electrical conductance at various time intervals during barrier repair. The test products were compared with acetone-treated air-exposed controls allowed to recover otherwise normally...

  13. Institutional and structural barriers for implementing on-farm water saving irrigation systems

    DEFF Research Database (Denmark)

    Pedersen, Søren Marcus; Boesen, Mads Vejlby; Ørum, Jens Erik

    2013-01-01

    Population growth and increased global water demand has intensified the need to apply water more efficiently. As the main global water user the agricultural sector needs special attention. In this study, the water saving potential of new drip irrigation systems has been investigated in five diffe...

  14. 78 FR 53467 - John H. Chafee Coastal Barrier Resources System; Delaware, North Carolina, South Carolina...

    Science.gov (United States)

    2013-08-29

    ..., as well as areas along the coasts of the Great Lakes, the U.S. Virgin Islands, and Puerto Rico. The... reclassified from T08P (an otherwise protected area) to T08 (a System unit). T11, T11P: SOUTH PADRE ISLAND UNIT... break between the Laguna Madre and South Padre Island that is visible on the base imagery. T12:...

  15. Laboratory column studies for evaluating a barrier system for providing oxygen and substrate for TCE biodegradation.

    Science.gov (United States)

    Kao, C M; Chen, S C; Su, M C

    2001-08-01

    The industrial solvent trichloroethylene (TCE) is among the most ubiquitous chlorinated compounds found in groundwater contamination. The objective of this study was to develop a biobarrier system containing oxygen-organic releasing material to enhance the aerobic cometabolism of TCE in situ. The oxygen-organic material, which contains calcium peroxide and peat, is able to release oxygen and primary substrates continuously upon contact with water. Batch experiments were conducted to design and identify the components of the oxygen-organic releasing material, and evaluate the oxygen and organic substrate (presented as COD equivalent) release from the designed oxygen-organic material. The observed oxygen and chemical oxygen demand (COD) release rates were approximately 0.0246 and 0.052 mg/d/g of material, respectively. A laboratory-scale column experiment was then conducted to evaluate the feasibility of this proposed system for the bioremediation of TCE-contaminated groundwater. This system was performed using a series of continuous-flow glass columns including a soil column, an oxygen-organic material column, followed by two consecutive soil columns. Aerobic acclimated sludges were inoculated in all three soil columns to provide microbial consortia for TCE biodegradation. Simulated TCE-contaminated groundwater with a flow rate of 0.25 l/day was pumped into this system. Effluent samples from each column were analyzed for TCE and other indicating parameters (e.g., pH, dissolved oxygen). Results show that the decreases in TCE concentrations were observed over a 4-month operating period. Up to 99% of TCE removal efficiency was obtained in this passive system. Results indicate that the continuously released oxygen and organic substrates from the oxygen-organic materials enhanced TCE biotransformation. Thus, the biobarrier treatment scheme has the potential to be developed into an environmentally and economically acceptable remediation technology.

  16. Barrier mechanisms in the Drosophila blood-brain barrier

    Directory of Open Access Journals (Sweden)

    Samantha Jane Hindle

    2014-12-01

    Full Text Available The invertebrate blood-brain barrier field is growing at a rapid pace and, in recent years, studies have shown a physiologic and molecular complexity that has begun to rival its vertebrate counterpart. Novel mechanisms of paracellular barrier maintenance through GPCR signaling were the first demonstrations of the complex adaptive mechanisms of barrier physiology. Building upon this work, the integrity of the invertebrate blood-brain barrier has recently been shown to require coordinated function of all layers of the compound barrier structure, analogous to signaling between the layers of the vertebrate neurovascular unit. These findings strengthen the notion that many blood-brain barrier mechanisms are conserved between vertebrates and invertebrates, and suggest that novel findings in invertebrate model organisms will have a significant impact on the understanding of vertebrate BBB functions. In this vein, important roles in coordinating localized and systemic signaling to dictate organism development and growth are beginning to show how the blood-brain barrier can govern whole animal physiologies. This includes novel functions of blood-brain barrier gap junctions in orchestrating synchronized neuroblast proliferation, and of blood-brain barrier secreted antagonists of insulin receptor signaling. These advancements and others are pushing the field forward in exciting new directions. In this review, we provide a synopsis of invertebrate blood-brain barrier anatomy and physiology, with a focus on insights from the past 5 years, and highlight important areas for future study.

  17. Barriers to the implementation of quality management system in media organizations in pakistan: an empirical study

    Directory of Open Access Journals (Sweden)

    Muhammad Naveed Anwar

    2012-12-01

    Full Text Available Quality management system has played pivotal role in establishing organizational functions and processes in the very right perspective of a very well knitted system of documentation, training and implementation. Media organizations are so close in their very existence and social structure and they are more than needed to stream line their processes as their impact on social life is significant and considerable. This study encompasses the top news channels in Pakistan and recorded the views of their top management with respect to their feelings pertaining to QMS. This study is very first one of its kinds in Pakistan and it is hoped that it may open more doors for future research avenues in this very area.

  18. REMOVAL OF ADDED NITRATE IN THE SINGLE, BINARY, AND TERNARY SYSTEMS OF COTTON BURR COMPOST, ZEROVALENT IRON, AND SEDIMENT: IMPLICATIONS FOR GROUNDWATER NITRATE REMEDIATION USING PERMEABLE REACTIVE BARRIERS

    Science.gov (United States)

    Recent research has shown that carbonaceous solid materials and zerovalent iron (Fe0) may potentially be used as media in permeable reactive barriers (PRBs) to degrade groundwater nitrate via heterotrophic denitrification in the solid carbon system, and via abiotic reduction and ...

  19. When health systems are barriers to health care: challenges faced by uninsured Mexican kidney patients.

    Directory of Open Access Journals (Sweden)

    Ciara Kierans

    Full Text Available BACKGROUND: Chronic Kidney Disease disproportionately affects the poor in Low and Middle Income Countries (LMICs. Mexico exemplifies the difficulties faced in supporting Renal Replacement Therapy (RRT and providing equitable patient care, despite recent attempts at health reform. The objective of this study is to document the challenges faced by uninsured, poor Mexican families when attempting to access RRT. METHODS: The article takes an ethnographic approach, using interviewing and observation to generate detailed accounts of the problems that accompany attempts to secure care. The study, based in the state of Jalisco, comprised interviews with patients, their caregivers, health and social care professionals, among others. Observations were carried out in both clinical and social settings. RESULTS: In the absence of organised health information and stable pathways to renal care, patients and their families work extraordinarily hard and at great expense to secure care in a mixed public-private healthcare system. As part of this work, they must navigate challenging health and social care environments, negotiate treatments and costs, resource and finance healthcare and manage a wide range of formal and informal health information. CONCLUSIONS: Examining commonalities across pathways to adequate healthcare reveals major failings in the Mexican system. These systemic problems serve to reproduce and deepen health inequalities. A system, in which the costs of renal care are disproportionately borne by those who can least afford them, faces major difficulties around the sustainability and resourcing of RRTs. Attempts to increase access to renal therapies, therefore, need to take into account the complex social and economic demands this places on those who need access most. This paper further shows that ethnographic studies of the concrete ways in which healthcare is accessed in practice provide important insights into the plight of CKD patients and so

  20. Conceptual Model for Radionuclide Release from the Engineered Barrier Systems (EBS) at Yucca Mountain

    Science.gov (United States)

    Hamdan, L. K.; Walton, J.; Woocay, A.

    2008-12-01

    Over time, nuclear waste packages at Yucca Mountain repository are likely to fail gradually or in stages, due to general or localized corrosion. Rock fall and other physical (or chemical) disturbances will lead to different general corrosion rates and different times of penetration. In the long run, the waste package is likely to evolve into a combination of failure locations mixed with relicts of intact Alloy-22 (or other waste package materials). Release of radionuclides (mostly by dissolution in water) from the waste packages is one of the most important factors determining the performance of the proposed Yucca Mountain repository. In this paper we develop a conceptual model of radionuclide release from the EBS. In this system, residual heat release in the waste, in conjunction with the capillary effect, is anticipated to set up flow systems in the relict protected areas, where liquid water flows into the protected area toward the warmest region, and vapor flows outward away from the warmest region - effectively preventing release and sometimes sequestering radionuclides in the relict sheltered areas (dead ends). We derive a dimensionless group that specifies the condition for the internal heat driven flow system, and estimates the minimum size of the covered areas required to sequester radionuclides and prevent release. Over time, the minimum area required for protection slowly increases while general corrosion decreases the average size of relict areas. Convolution of the two processes suggests that radionuclide release from the flow-through system of partially failed waste packages will be gradual and long delayed (100,000 - 1,000,000 years), even in the case of early penetration by localized corrosion.

  1. The EcoKI Type I Restriction-Modification System in Escherichia coli Affects but Is Not an Absolute Barrier for Conjugation

    DEFF Research Database (Denmark)

    Roer, Louise; Aarestrup, Frank Møller; Hasman, Henrik

    2015-01-01

    results about restriction-modification systems based on phenotypic studies have been presented as reasons for a barrier to conjugation with and other means of uptake of exogenous DNA. In this study, we show that inactivation of the R.EcoKI restriction enzyme in strain Escherichia coli K-12 strain MG1655...... of the mutant recipient with a disrupted hsdR gene. This leads to the conclusion that EcoKI restriction-modification affects the uptake of DNA by conjugation but is not a major barrier to plasmid transfer....

  2. Identification and ranking barriers and drivers of e-commerce with the approach of organizational agility and fuzzy logic (Case study: public and private banks selected by city of Shiraz

    Directory of Open Access Journals (Sweden)

    Abdolreza Naddaf

    2016-06-01

    Full Text Available The rapid and increasing expansion of e-commerce through web sites and portals has caused identification and measurement of critical factors of e-commerce to be considered an essential and necessary affair. The main objective of this research is to identify and rank the barriers and motives of e-commerce with organization agility and fuzzy logic approach (Case Study: public and private banks selected from Shiraz city. Hence, the conceptual model was created based on the research literature and theoretical framework to assess the barriers and motives of e-commerce and organization agility. Methodology is quantitative of descriptive - survey type. The tool used in the research is questionnaire. For this purpose, 200 employees of public and private banks selected from Shiraz city have been selected in random sampling method by using Morgan Table. Then the questionnaire has been filled by them. 30 experts were also selected for paired comparisons questionnaire sample. The questionnaires' validity has been measured by using review of specialist professors' views. Questionnaires' reliability was evaluated by Cronbach's alpha criterion. Here Cronbach's alpha has become 0.93. Multiple Criteria Decision Making technique (MCDM and Fuzzy Analytic Hierarchy Process (AHP and Expert choice software were used in this research meantime analyzing and evaluating factors of barriers and motives of e-commerce for evaluating and ranking them. Deterrent factors of e-commerce in bank and driving factors of e-commerce in bank and organization agility were identified. Then the importance degree of each of them was determined in order of priority.

  3. Analysis on Insulation Structure of Barrier System of Converter Transformer%换流变压器出线装置的绝缘结构分析

    Institute of Scientific and Technical Information of China (English)

    蒋蓁

    2011-01-01

    Reliability of DC barrier system is one of key points of converter transformer's R&D. DC barrier systems are imported over the years. Optimization of insulation structure of barrier system has significant influence on further speeding up localization manufacture of converter transformer in China. The operation characteristic of converter transformer was summarized, and the insulation structure of barrier system was studied. Furthermore, the calculation of electric field of insulation structure for DC barrier system was made. Converter transformer has features as high short circuit impedance, DC bias current influence, serious influence of harmonic and complicated insulation structure. Electric field analysis and calculation was carried on the basis of typical insulation structure of DC barrier system for different models under different testing condition, such as long duration AC applied voltage withstand test, DC voltage withstand test with PD measurement and polarity reversal test to summarize design concept and main points to structure of DC barrier system. Test results show that the developed insulation structure of DC barrier system is reasonable, which has been approved by the test. The same theory and method will be applied to insulation structure electric field analysis of DC barrier system of converter transformer with higher voltage level to optimize the sound insulation structure of DC barrier system.%换流变压器直流出线装置的可靠性是换流变压器研制的关键问题之一,长期以来直流出线装置依靠进口,优化出合理的直流出线装置绝缘结构对进一步促进换流变压器设备制造全面国产化具有重要的意义.笔者总结了换流变压器的运行特点,研究了直流出线装置的绝缘结构,并进行了直流出线装置绝缘结构的电场计算.换流变压器的运行特点为短路阻抗大、直流偏磁影响、谐波影响严重,绝缘结构复杂,针对典型的直流出线装置绝缘

  4. Patient- and system-related barriers for the earlier diagnosis of colorectal cancer

    Science.gov (United States)

    Wahls, Terry L; Peleg, Ika

    2009-01-01

    Background A cohort of colorectal cancer (CRC) patients represents an opportunity to study missed opportunities for earlier diagnosis. Primary objective: To study the epidemiology of diagnostic delays and failures to offer/complete CRC screening. Secondary objective: To identify system- and patient-related factors that may contribute to diagnostic delays or failures to offer/complete CRC screening. Methods Setting: Rural Veterans Administration (VA) Healthcare system. Participants: CRC cases diagnosed within the VA between 1/1/2000 and 3/1/2007. Data sources: progress notes, orders, and pathology, laboratory, and imaging results obtained between 1/1/1995 and 12/31/2007. Completed CRC screening was defined as a fecal occult blood test or flexible sigmoidoscopy (both within five years), or colonoscopy (within 10 years); delayed diagnosis was defined as a gap of more than six months between an abnormal test result and evidence of clinician response. A summary abstract of the antecedent clinical care for each patient was created by a certified gastroenterologist (GI), who jointly reviewed and coded the abstracts with a general internist (TW). Results The study population consisted of 150 CRC cases that met the inclusion criteria. The mean age was 69.04 (range 35-91); 99 (66%) were diagnosed due to symptoms; 61 cases (46%) had delays associated with system factors; of them, 57 (38% of the total) had delayed responses to abnormal findings. Fifteen of the cases (10%) had prompt symptom evaluations but received no CRC screening; no patient factors were identified as potentially contributing to the failure to screen/offer to screen. In total, 97 (65%) of the cases had missed opportunities for early diagnosis and 57 (38%) had patient factors that likely contributed to the diagnostic delay or apparent failure to screen/offer to screen. Conclusion Missed opportunities for earlier CRC diagnosis were frequent. Additional studies of clinical data management, focusing on following

  5. Patient- and system-related barriers for the earlier diagnosis of colorectal cancer

    Directory of Open Access Journals (Sweden)

    Wahls Terry L

    2009-09-01

    Full Text Available Abstract Background A cohort of colorectal cancer (CRC patients represents an opportunity to study missed opportunities for earlier diagnosis. Primary objective: To study the epidemiology of diagnostic delays and failures to offer/complete CRC screening. Secondary objective: To identify system- and patient-related factors that may contribute to diagnostic delays or failures to offer/complete CRC screening. Methods Setting: Rural Veterans Administration (VA Healthcare system. Participants: CRC cases diagnosed within the VA between 1/1/2000 and 3/1/2007. Data sources: progress notes, orders, and pathology, laboratory, and imaging results obtained between 1/1/1995 and 12/31/2007. Completed CRC screening was defined as a fecal occult blood test or flexible sigmoidoscopy (both within five years, or colonoscopy (within 10 years; delayed diagnosis was defined as a gap of more than six months between an abnormal test result and evidence of clinician response. A summary abstract of the antecedent clinical care for each patient was created by a certified gastroenterologist (GI, who jointly reviewed and coded the abstracts with a general internist (TW. Results The study population consisted of 150 CRC cases that met the inclusion criteria. The mean age was 69.04 (range 35-91; 99 (66% were diagnosed due to symptoms; 61 cases (46% had delays associated with system factors; of them, 57 (38% of the total had delayed responses to abnormal findings. Fifteen of the cases (10% had prompt symptom evaluations but received no CRC screening; no patient factors were identified as potentially contributing to the failure to screen/offer to screen. In total, 97 (65% of the cases had missed opportunities for early diagnosis and 57 (38% had patient factors that likely contributed to the diagnostic delay or apparent failure to screen/offer to screen. Conclusion Missed opportunities for earlier CRC diagnosis were frequent. Additional studies of clinical data management

  6. Electronic clinical decision support systems attitudes and barriers to use in the oncology setting.

    LENUS (Irish Health Repository)

    Collins, I M

    2012-03-02

    BACKGROUND: There is little evidence regarding attitudes to clinical decision support systems (CDSS) in oncology. AIMS: We examined the current usage, awareness, and concerns of Irish medical oncologists and oncology pharmacists in this area. METHODS: A questionnaire was sent to 27 medical oncologists and 34 oncology pharmacists, identified through professional interest groups. Respondents ranked concerns regarding their use of a CDSS on a scale from 1 to 4, with 4 being most important. RESULTS: Overall, 67% (41\\/61) responded, 48% (13\\/27) of oncologists and 82% (28\\/34) of pharmacists surveyed. Concerns included "difficulty defining complex clinical situations with a set of rules" (mean ± SD) (3.2 ± 0.9), "ensuring evidence base is up to date and relevant" (3.2 ± 0.9) and "lack of clinically relevant suggestions" (2.9 ± 0.9). Ninety-three percent reported using a CDSS but 54% were unaware of this. CONCLUSION: While there are benefits to using a CDSS, concerns must be addressed through user education. This may be a starting point for a user-centred design approach to the development of future local systems through a consultative process.

  7. A Model for Service Life Control of Selected Device Systems

    Directory of Open Access Journals (Sweden)

    Zieja Mariusz

    2014-04-01

    Full Text Available This paper presents a way of determining distribution of limit state exceedence time by a diagnostic parameter which determines accuracy of maintaining zero state. For calculations it was assumed that the diagnostic parameter is deviation from nominal value (zero state. Change of deviation value occurs as a result of destructive processes which occur during service. For estimation of deviation increasing rate in probabilistic sense, was used a difference equation from which, after transformation, Fokker-Planck differential equation was obtained [4, 11]. A particular solution of the equation is deviation increasing rate density function which was used for determining exceedance probability of limit state. The so-determined probability was then used to determine density function of limit state exceedance time, by increasing deviation. Having at disposal the density function of limit state exceedance time one determined service life of a system of maladjustment. In the end, a numerical example based on operational data of selected aircraft [weapon] sights was presented. The elaborated method can be also applied to determining residual life of shipboard devices whose technical state is determined on the basis of analysis of values of diagnostic parameters.

  8. Sustainable fuel, food, fertilizer and ecosystems through a global artificial photosynthetic system: overcoming anticompetitive barriers

    Science.gov (United States)

    Bruce, Alex; Faunce, Thomas

    2015-01-01

    This article discusses challenges that artificial photosynthetic (AP) systems will face when entering and competing in a global market characterized by established fossil fuel technology. It provides a perspective on the neoliberal principles underpinning much policy entrenching such environmentally destructive technology and outlines how competition law could aid overcoming these hurdles for AP development. In particular, it critiques the potential for competition law to promote a global AP initiative with greater emphasis on atmospheric carbon dioxide and nitrogen fixation (as well as solar-driven water splitting) to produce an equitable, globally distributed source of human food, fertilizer and biosphere sustainability, as well as hydrogen-based fuel. Some relevant strategies of competition law evaluated in this context include greater citizen–consumer involvement in shaping market values, legal requirements to factor services from the natural environment (i.e. provision of clean air, water, soil pollution degradation) into corporate costs, reform of corporate taxation and requirements to balance maximization of shareholder profit with contribution to a nominated public good, a global financial transactions tax, as well as prohibiting horizontal cartels, vertical agreements and unilateral misuse of market power. PMID:26052427

  9. One-dimensional free-energy profiles of complex systems: progress variables that preserve the barriers.

    Science.gov (United States)

    Krivov, Sergei V; Karplus, Martin

    2006-06-29

    We show that the balanced minimum-cut procedure introduced in PNAS 2004, 101, 14766 can be reinterpreted as a method for solving the constrained optimization problem of finding the minimum cut among the cuts with a particular value of an additive function of the nodes on either side of the cut. Such an additive function (e.g., the partition function of the reactant region) can be used as a progress coordinate to determine a one-dimensional profile (FEP) of the free-energy surface of the protein-folding reaction as well as other complex reactions. The algorithm is based on the network (obtained from an equilibrium molecular dynamics simulation) that represents the calculated reaction behavior. The resulting FEP gives the exact values of the free energy as a function of the progress coordinate; i.e., at each value of the progress coordinate, the profile is obtained from the surface with the minimal partition function among the surfaces that divide the full free-energy surface between two chosen end points. In many cases, the balanced minimum-cut procedure gives results for only a limited set of points. An approximate method based on p(fold) is shown to provide the profile for a more complete set of values of the progress coordinate. Applications of the approach to model problems and to realistic systems (beta-hairpin of protein G, LJ38 cluster) are presented.

  10. Epithelial barrier: an interface for the cross-communication between gut flora and immune system.

    Science.gov (United States)

    Goto, Yoshiyuki; Kiyono, Hiroshi

    2012-01-01

    Large numbers of environmental antigens, including commensal bacteria and food-derived antigens, constitutively interact with the epithelial layer of the gastrointestinal (GI) tract. Commensal bacteria peacefully cohabit with the host GI tract and exert multiple beneficial or destructive effects on their host. Intestinal epithelial cells (IECs) constitute the first physical and immunological protective wall against invasive pathogens and a cohabitation niche for commensal bacteria. As the physiological homeostasis of IECs is maintained by multiple biological processes such as apoptosis, autophagy, and the handling of endoplasmic reticulum stress, the aberrant kinetics of these biological events, which have genetic and environmental causes, leads to the development of host intestinal pathogenesis such as inflammatory bowel disease. In addition, IECs recognize and interact with commensal bacteria and give instructions to mucosal immune cells to initiate an immunological balance between active and quiescent conditions, eventually establishing intestinal homeostasis. The mucosal immune system regulates the homeostasis of gut microbiota by producing immunological molecules such as secretory immunoglobulin A, the production of which is mediated by IECs. IECs therefore play a central role in the creation and maintenance of a physiologically and immunologically stable intestinal environment.

  11. Sustainable fuel, food, fertilizer and ecosystems through a global artificial photosynthetic system: overcoming anticompetitive barriers.

    Science.gov (United States)

    Bruce, Alex; Faunce, Thomas

    2015-06-06

    This article discusses challenges that artificial photosynthetic (AP) systems will face when entering and competing in a global market characterized by established fossil fuel technology. It provides a perspective on the neoliberal principles underpinning much policy entrenching such environmentally destructive technology and outlines how competition law could aid overcoming these hurdles for AP development. In particular, it critiques the potential for competition law to promote a global AP initiative with greater emphasis on atmospheric carbon dioxide and nitrogen fixation (as well as solar-driven water splitting) to produce an equitable, globally distributed source of human food, fertilizer and biosphere sustainability, as well as hydrogen-based fuel. Some relevant strategies of competition law evaluated in this context include greater citizen-consumer involvement in shaping market values, legal requirements to factor services from the natural environment (i.e. provision of clean air, water, soil pollution degradation) into corporate costs, reform of corporate taxation and requirements to balance maximization of shareholder profit with contribution to a nominated public good, a global financial transactions tax, as well as prohibiting horizontal cartels, vertical agreements and unilateral misuse of market power.

  12. Residual Stresses in Thermal Barrier Coatings for a Cu-8Cr-4Nb Substrate System

    Science.gov (United States)

    Ghosn, Louis J.; Raj, Sai V.

    2002-01-01

    Analytical calculations were conducted to determine the thermal stresses developed in a coated copper-based alloy, Cu-8%(at.%)Cr-4%Nb (designated as GRCop-84), after plasma spraying and during heat-up in a simulated rocket engine environment. Finite element analyses were conducted for two coating systems consisting of a metallic top coat, a pure copper bond coat and the GRCop-84. The through thickness temperature variations were determined as a function of coating thickness for two metallic coatings, a Ni-17%(wt%)Cr-6%Al-0.5%Y alloy and a Ni-50%(at.%)Al alloy. The residual stresses after low-pressure plasma spraying of the NiCrAlY and NiAl coatings on GRCop-84 substrate were also evaluated. These analyses took into consideration a 50.8 mm copper bond coat and the effects of an interface coating roughness. The through the thickness thermal stresses developed in coated liners were also calculated after 15 minutes of exposure in a rocket environment with and without an interfacial roughness.

  13. Chemical gel barriers as low-cost alternative to containment and in situ cleanup of hazardous wastes to protect groundwater

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-01-01

    Chemical gel barriers are being considered as a low-cost alternative for containment and in situ cleanup of hazardous wastes to protect groundwater. Most of the available gels in petroleum application are non-reactive and relative impermeable, providing a physical barriers for all fluids and contaminants. However, other potential systems can be envisioned. These systems could include gels that are chemically reactive and impermeable such that most phase are captured by the barriers but the contaminants could diffuse through the barriers. Another system that is chemically reactive and permeable could have potential applications in selectivity capturing contaminants while allowing water to pass through the barriers. This study focused on chemically reactive and permeable gel barriers. The gels used in experiment are DuPont LUDOX SM colloidal silica gel and Pfizer FLOPAAM 1330S hydrolyzed polyacrylamide (HPAM) gel.

  14. C5a alters blood-brain barrier integrity in a human in vitro model of systemic lupus erythematosus.

    Science.gov (United States)

    Mahajan, Supriya D; Parikh, Neil U; Woodruff, Trent M; Jarvis, James N; Lopez, Molly; Hennon, Teresa; Cunningham, Patrick; Quigg, Richard J; Schwartz, Stanley A; Alexander, Jessy J

    2015-09-01

    The blood-brain barrier (BBB) plays a crucial role in brain homeostasis, thereby maintaining the brain environment precise for optimal neuronal function. Its dysfunction is an intriguing complication of systemic lupus erythematosus (SLE). SLE is a systemic autoimmune disorder where neurological complications occur in 5-50% of cases and is associated with impaired BBB integrity. Complement activation occurs in SLE and is an important part of the clinical profile. Our earlier studies demonstrated that C5a generated by complement activation caused the loss of brain endothelial layer integrity in rodents. The goal of the current study was to determine the translational potential of these studies to a human system. To assess this, we used a two dimensional in vitro BBB model constructed using primary human brain microvascular endothelial cells and astroglial cells, which closely emulates the in vivo BBB allowing the assessment of BBB integrity. Increased permeability monitored by changes in transendothelial electrical resistance and cytoskeletal remodelling caused by actin fiber rearrangement were observed when the cells were exposed to lupus serum and C5a, similar to the observations in mice. In addition, our data show that C5a/C5aR1 signalling alters nuclear factor-κB translocation into nucleus and regulates the expression of the tight junction proteins, claudin-5 and zonula occludens 1 in this setting. Our results demonstrate for the first time that C5a regulates BBB integrity in a neuroinflammatory setting where it affects both endothelial and astroglial cells. In addition, we also demonstrate that our previous findings in a mouse model, were emulated in human cells in vitro, bringing the studies one step closer to understanding the translational potential of C5a/C5aR1 blockade as a promising therapeutic strategy in SLE and other neurodegenerative diseases.

  15. Criteria of benchmark selection for efficient flexible multibody system formalisms

    Directory of Open Access Journals (Sweden)

    Valášek M.

    2007-10-01

    Full Text Available The paper deals with the selection process of benchmarks for testing and comparing efficient flexible multibody formalisms. The existing benchmarks are briefly summarized. The purposes for benchmark selection are investigated. The result of this analysis is the formulation of the criteria of benchmark selection for flexible multibody formalisms. Based on them the initial set of suitable benchmarks is described. Besides that the evaluation measures are revised and extended.

  16. Identifying the Barriers to Women's Agency in Domestic Violence: The Tensions between Women's Personal Experiences and Systemic Responses

    Directory of Open Access Journals (Sweden)

    Jo Aldridge

    2013-04-01

    Full Text Available Despite advances in knowledge and understanding about the impacts of domestic violence on women's lives, global research on violence against women shows there is a need for research that not only places women centre stage in research praxis, but also that involves them more collaboratively in genuine dialogue about their experiences, including their agentic stances. This is especially the case for marginalised and socially excluded women victims of domestic violence, such as those who are not known or do not present to services and who survive abusive relationships alone or with little outside support. Evidence from two studies reported here—secondary analysis of women with severe and enduring mental health problems and a collaborative narrative project with unsupported women victims of domestic violence—suggest that women's capacity for agency are compromised by a number of critical factors, and that these are also reflected in the tensions between micro–macro analyses and understanding of the impact of domestic violence on women. This article considers the barriers to women's agency from the women's perspective and in the context of broader, systemic dynamics, including the denial or obscuring of abuse by governments and states and the consequences of stringent fiscal retrenchment that put women at increased risk of domestic violence.

  17. Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle

    Science.gov (United States)

    Vernetti, Lawrence; Gough, Albert; Baetz, Nicholas; Blutt, Sarah; Broughman, James R.; Brown, Jacquelyn A.; Foulke-Abel, Jennifer; Hasan, Nesrin; In, Julie; Kelly, Edward; Kovbasnjuk, Olga; Repper, Jonathan; Senutovitch, Nina; Stabb, Janet; Yeung, Catherine; Zachos, Nick C.; Donowitz, Mark; Estes, Mary; Himmelfarb, Jonathan; Truskey, George; Wikswo, John P.; Taylor, D. Lansing

    2017-01-01

    Organ interactions resulting from drug, metabolite or xenobiotic transport between organs are key components of human metabolism that impact therapeutic action and toxic side effects. Preclinical animal testing often fails to predict adverse outcomes arising from sequential, multi-organ metabolism of drugs and xenobiotics. Human microphysiological systems (MPS) can model these interactions and are predicted to dramatically improve the efficiency of the drug development process. In this study, five human MPS models were evaluated for functional coupling, defined as the determination of organ interactions via an in vivo-like sequential, organ-to-organ transfer of media. MPS models representing the major absorption, metabolism and clearance organs (the jejunum, liver and kidney) were evaluated, along with skeletal muscle and neurovascular models. Three compounds were evaluated for organ-specific processing: terfenadine for pharmacokinetics (PK) and toxicity; trimethylamine (TMA) as a potentially toxic microbiome metabolite; and vitamin D3. We show that the organ-specific processing of these compounds was consistent with clinical data, and discovered that trimethylamine-N-oxide (TMAO) crosses the blood-brain barrier. These studies demonstrate the potential of human MPS for multi-organ toxicity and absorption, distribution, metabolism and excretion (ADME), provide guidance for physically coupling MPS, and offer an approach to coupling MPS with distinct media and perfusion requirements. PMID:28176881

  18. Exploring barriers to participation and adoption of telehealth and telecare within the Whole System Demonstrator trial: a qualitative study

    Directory of Open Access Journals (Sweden)

    Sanders Caroline

    2012-07-01

    Full Text Available Abstract Background Telehealth (TH and telecare (TC interventions are increasingly valued for supporting self-care in ageing populations; however, evaluation studies often report high rates of non-participation that are not well understood. This paper reports from a qualitative study nested within a large randomised controlled trial in the UK: the Whole System Demonstrator (WSD project. It explores barriers to participation and adoption of TH and TC from the perspective of people who declined to participate or withdrew from the trial. Methods Qualitative semi-structured interviews were conducted with 22 people who declined to participate in the trial following explanations of the intervention (n = 19, or who withdrew from the intervention arm (n = 3. Participants were recruited from the four trial groups (with diabetes, chronic obstructive pulmonary disease, heart failure, or social care needs; and all came from the three trial areas (Cornwall, Kent, east London. Observations of home visits where the trial and interventions were first explained were also conducted by shadowing 8 members of health and social care staff visiting 23 people at home. Field notes were made of observational visits and explored alongside interview transcripts to elicit key themes. Results Barriers to adoption of TH and TC associated with non-participation and withdrawal from the trial were identified within the following themes: requirements for technical competence and operation of equipment; threats to identity, independence and self-care; expectations and experiences of disruption to services. Respondents held concerns that special skills were needed to operate equipment but these were often based on misunderstandings. Respondents’ views were often explained in terms of potential threats to identity associated with positive ageing and self-reliance, and views that interventions could undermine self-care and coping. Finally, participants were reluctant to

  19. Potential structural barriers to ground-water flow, Death Valley regional ground-water flow system, Nevada and California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This digital dataset defines the surface traces of regional geologic structures designated as potential ground-water flow barriers in an approximately 45,000...

  20. Artificial immune system based on adaptive clonal selection for feature selection and parameters optimisation of support vector machines

    Science.gov (United States)

    Sadat Hashemipour, Maryam; Soleimani, Seyed Ali

    2016-01-01

    Artificial immune system (AIS) algorithm based on clonal selection method can be defined as a soft computing method inspired by theoretical immune system in order to solve science and engineering problems. Support vector machine (SVM) is a popular pattern classification method with many diverse applications. Kernel parameter setting in the SVM training procedure along with the feature selection significantly impacts on the classification accuracy rate. In this study, AIS based on Adaptive Clonal Selection (AISACS) algorithm has been used to optimise the SVM parameters and feature subset selection without degrading the SVM classification accuracy. Several public datasets of University of California Irvine machine learning (UCI) repository are employed to calculate the classification accuracy rate in order to evaluate the AISACS approach then it was compared with grid search algorithm and Genetic Algorithm (GA) approach. The experimental results show that the feature reduction rate and running time of the AISACS approach are better than the GA approach.

  1. Determining collective barrier operation skew in a parallel computer

    Energy Technology Data Exchange (ETDEWEB)

    Faraj, Daniel A.

    2015-11-24

    Determining collective barrier operation skew in a parallel computer that includes a number of compute nodes organized into an operational group includes: for each of the nodes until each node has been selected as a delayed node: selecting one of the nodes as a delayed node; entering, by each node other than the delayed node, a collective barrier operation; entering, after a delay by the delayed node, the collective barrier operation; receiving an exit signal from a root of the collective barrier operation; and measuring, for the delayed node, a barrier completion time. The barrier operation skew is calculated by: identifying, from the compute nodes' barrier completion times, a maximum barrier completion time and a minimum barrier completion time and calculating the barrier operation skew as the difference of the maximum and the minimum barrier completion time.

  2. Barriers in access to healthcare in countries with different health systems. A cross-sectional study in municipalities of central Colombia and north-eastern Brazil.

    Science.gov (United States)

    Garcia-Subirats, Irene; Vargas, Ingrid; Mogollón-Pérez, Amparo Susana; De Paepe, Pierre; da Silva, Maria Rejane Ferreira; Unger, Jean Pierre; Vázquez, María Luisa

    2014-04-01

    There are few comprehensive studies available on barriers encountered from the initial seeking of healthcare through to the resolution of the health problem; in other words, on access in its broad domain. For Colombia and Brazil, countries with different healthcare systems but common stated principles, there have been no such analyses to date. This paper compares factors that influence access in its broad domain in two municipalities of each country, by means of a cross-sectional study based on a survey of a multistage probability sample of people who had had at least one health problem within the last three months (2163 in Colombia and 2155 in Brazil). The results reveal important barriers to healthcare access in both samples, with notable differences between and within countries, once differences in sociodemographic characteristics and health needs are accounted for. In the Colombian study areas, the greatest barriers were encountered in initial access to healthcare and in resolving the problem, and similarly when entering the health service in the Brazilian study areas. Differences can also be detected in the use of services: in Colombia greater geographical and economic barriers and the need for authorization from insurers are more relevant, whereas in Brazil, it is the limited availability of health centres, doctors and drugs that leads to longer waiting times. There are also differences according to enrolment status and insurance scheme in Colombia, and between areas in Brazil. The barriers appear to be related to the Colombian system's segmented, non-universal nature, and to the involvement of insurance companies, and to chronic underfunding of the public system in Brazil. Further research is required, but the results obtained reveal critical points to be tackled by health policies in both countries.

  3. In vitro selection with artificial expanded genetic information systems.

    Science.gov (United States)

    Sefah, Kwame; Yang, Zunyi; Bradley, Kevin M; Hoshika, Shuichi; Jiménez, Elizabeth; Zhang, Liqin; Zhu, Guizhi; Shanker, Savita; Yu, Fahong; Turek, Diane; Tan, Weihong; Benner, Steven A

    2014-01-28

    Artificially expanded genetic information systems (AEGISs) are unnatural forms of DNA that increase the number of independently replicating nucleotide building blocks. To do this, AEGIS pairs are joined by different arrangements of hydrogen bond donor and acceptor groups, all while retaining their Watson-Crick geometries. We report here a unique case where AEGIS DNA has been used to execute a systematic evolution of ligands by exponential enrichment (SELEX) experiment. This AEGIS-SELEX was designed to create AEGIS oligonucleotides that bind to a line of breast cancer cells. AEGIS-SELEX delivered an AEGIS aptamer (ZAP-2012) built from six different kinds of nucleotides (the standard G, A, C, and T, and the AEGIS nonstandard P and Z nucleotides, the last having a nitro functionality not found in standard DNA). ZAP-2012 has a dissociation constant of 30 nM against these cells. The affinity is diminished or lost when Z or P (or both) is replaced by standard nucleotides and compares well with affinities of standard GACT aptamers selected against cell lines using standard SELEX. The success of AEGIS-SELEX relies on various innovations, including (i) the ability to synthesize GACTZP libraries, (ii) polymerases that PCR amplify GACTZP DNA with little loss of the AEGIS nonstandard nucleotides, and (iii) technologies to deep sequence GACTZP DNA survivors. These results take the next step toward expanding the power and utility of SELEX and offer an AEGIS-SELEX that could possibly generate receptors, ligands, and catalysts having sequence diversities nearer to that displayed by proteins.

  4. Health system barriers to strengthening vaccine-preventable disease surveillance and response in the context of decentralization: evidence from Georgia

    Directory of Open Access Journals (Sweden)

    Silvestre Eva A

    2006-07-01

    Full Text Available Abstract Background A critical challenge in the health sector in developing countries is to ensure the quality and effectiveness of surveillance and public health response in an environment of decentralization. In Georgia, a country where there has been extensive decentralization of public health responsibilities over the last decade, an intervention was recently piloted to strengthen district-level local vaccine-preventable disease surveillance and response activities through improved capacity to analyze and use routinely collected data. The purpose of the study is 1 to assess the effectiveness of the intervention on motivation and perceived capacity to analyze and use information at the district-level, and 2 to assess the role that individual- and system-level factors play in influencing the effectiveness of the intervention. Methods A pre-post quasi-experimental research design is used for the quantitative evaluation. Data come from a baseline and two follow-up surveys of district-level health staff in 12 intervention and 3 control Center of Public Health (CPH offices. These data were supplemented by record reviews in CPH offices as well as focus group discussions among CPH and health facility staff. Results The results of the study suggest that a number of expected improvements in perceived data availability and analysis occurred following the implementation of the intervention package, and that these improvements in analysis could be attributable to the intervention package. However, the study results also suggest that there exist several health systems barriers that constrained the effectiveness of the intervention in influencing the availability of data, analysis and response. Conclusion To strengthen surveillance and response systems in Georgia, as well as in other countries, donor, governments, and other stakeholders should consider how health systems factors influence investments to improve the availability of data, analysis, and

  5. PS2-13: Implementing a Lean Management System in Primary Care: Facilitators and Barriers from the Frontlines

    Science.gov (United States)

    Hung, Dorothy; Gray, Caroline; Anderson, Katie; Hereford, James

    2013-01-01

    Background/Aims As approximately $750 billion is wasted in the U.S. health system each year, equivalent to roughly one-third of every medical dollar, “Lean” thinking and techniques offer promising solutions for maximizing value in health care. This study examines a large, multispecialty practice’s journey of implementing a Lean management system beginning in primary care. We sought to understand initial drivers and barriers to implementation, with lessons contributing to a learning system of improvement in health care. Methods This case study was based on in-depth interviews with 16 physician and administrative leaders, and 4 focus groups of medical assistants and administrative staff. Transcripts were coded and analyzed using inductive, grounded methodology. Results Respondents’ insights were clustered around three main themes: organizational leadership, professional values/culture, and availability of resources. Informants described organizational characteristics critical to implementing Lean and to which they attributed its success so far, including: strong leadership and the importance that leaders embody qualities they are espousing, willingness to engage all levels of staff in the change process, and willingness to adjust performance measures according to new job roles. However, many noted that values and norms surrounding clinical practice are often at odds with the Lean principle of standardizing work to eliminate waste, representing the biggest challenge for physicians who are socialized into a culture where independent thinking and autonomy is valued. The availability of resources was also cited as an important factor in executing changes, including time to do one’s regular work while implementing change, time to absorb new ideas and changes, and proper space configurations to support the change. Conclusions Lean represents a non-traditional approach to managing the delivery of medical care. In a Lean operating system, value is seen first from

  6. Diffraction of sound by nearly rigid barriers

    Science.gov (United States)

    Hadden, W. J., Jr.; Pierce, A. D.

    1976-01-01

    The diffraction of sound by barriers with surfaces of large, but finite, acoustic impedance was analyzed. Idealized source-barrier-receiver configurations in which the barriers may be considered as semi-infinite wedges are discussed. Particular attention is given to situations in which the source and receiver are at large distances from the tip of the wedge. The expression for the acoustic pressure in this limiting case is compared with the results of Pierce's analysis of diffraction by a rigid wedge. An expression for the insertion loss of a finite impedance barrier is compared with insertion loss formulas which are used extensively in selecting or designing barriers for noise control.

  7. Development of expert system for biobased polymer material selection: food packaging application.

    Science.gov (United States)

    Sanyang, M L; Sapuan, S M

    2015-10-01

    Biobased food packaging materials are gaining more attention owing to their intrinsic biodegradable nature and renewability. Selection of suitable biobased polymers for food packaging applications could be a tedious task with potential mistakes in choosing the best materials. In this paper, an expert system was developed using Exsys Corvid software to select suitable biobased polymer materials for packaging fruits, dry food and dairy products. If - Then rule based system was utilized to accomplish the material selection process whereas a score system was formulated to facilitate the ranking of selected materials. The expert system selected materials that satisfied all constraints and selection results were presented in suitability sequence depending on their scores. The expert system selected polylactic acid (PLA) as the most suitable material.

  8. Opportunities for functional oxides in yttrium oxide-titanium oxide-zirconium oxide system: Applications for novel thermal barrier coatings

    Science.gov (United States)

    Francillon, Wesley

    This dissertation is an investigation of materials and processed under consideration for next generation thermal structural oxides with potential applications as thermal barrier coatings; wherein, high temperature stability and mechanical properties affect durability. Two notable next generation materials systems under investigation are pyrochlore and co-doped zirconia oxides. The motivation for this work is based on current limitations of the currently used thermal barrier material of yttria stabilized zirconia (YSZ) deposited by the plasma spray processes. The rapid quenching associated with the plasma spray process, results in a metastable structure that is a non-transformable tetragonal structure in the yttria partially stabilized zirconia system rather than the equilibrium anticipated two phase mixture of cubic and monoclinic phases. It has been shown that this metastable structure offers enhanced toughness and thus durability during thermomechanical cycling from the operating temperatures in excess of 1000C to ambient. However, the metastable oxides are susceptible to partitioning at temperatures greater than 1200C, thus resulting in a transformation of the tetragonal phase oxides. Transformations of the tetragonal prime phase into the parent cubic and tetragonal prime phase result in coating degradation. Several of the emerging oxides are based on rare earth additions to zirconia. However, there is limited information of the high temperature stability of these oxide coatings and more notably these compositions exhibit limited toughness for durable performance. A potential ternary composition based on the YSZ system that offers the ability to tailor the phase structure is based YO1.5-TiO2 -ZrO2. The ternary of YO1.5-TiO2-ZrO 2 has the current TBC composition of seven molar percent yttria stabilized zirconia, pyrochlore phase oxide and zirconia doped with yttria and titania additions (Ti-YSZ). The Ti-YSZ phase field is of interest because at equilibrium it is

  9. Effect of thermal barrier coatings on the performance of steam and water-cooled gas turbine/steam turbine combined cycle system

    Science.gov (United States)

    Nainiger, J. J.

    1978-01-01

    An analytical study was made of the performance of air, steam, and water-cooled gas-turbine/steam turbine combined-cycle systems with and without thermal-barrier coatings. For steam cooling, thermal barrier coatings permit an increase in the turbine inlet temperature from 1205 C (2200 F), resulting in an efficiency improvement of 1.9 percentage points. The maximum specific power improvement with thermal barriers is 32.4 percent, when the turbine inlet temperature is increased from 1425 C (2600 F) to 1675 C (3050 F) and the airfoil temperature is kept the same. For water cooling, the maximum efficiency improvement is 2.2 percentage points at a turbine inlet temperature of 1683 C (3062 F) and the maximum specific power improvement is 36.6 percent by increasing the turbine inlet temperature from 1425 C (2600 F) to 1730 C (3150 F) and keeping the airfoil temperatures the same. These improvements are greater than that obtained with combined cycles using air cooling at a turbine inlet temperature of 1205 C (2200 F). The large temperature differences across the thermal barriers at these high temperatures, however, indicate that thermal stresses may present obstacles to the use of coatings at high turbine inlet temperatures.

  10. Fusion near and below the barrier for the systems 32,34S+24,25,26Mg and 32S+27Al

    Science.gov (United States)

    Berkowitz, G. M.; Braun-Munzinger, P.; Karp, J. S.; Freifelder, R. H.; Renner, T. R.; Wilschut, H. W.

    1983-08-01

    Excitation functions are reported for total fusion near and below the Coulomb barrier of the systems 32,34S+24,25,26Mg and 27Al. The data cannot be reproduced by one-dimensional barrier penetration calculations. The enhancement of the cross sections at low energies is compared to predictions of models taking into acount the static deformation or zero point vibration of the reaction partners. Calculations including zero point motion do not reproduce the observed variations of the measured cross sections with respect to the neutron number of target and projectile. Reasonable agreement is obtained when calculating fusion between statically deformed nuclei. Finally, the fusion process is described in a quantum mechanical coupled channels model, indicating the importance of dynamical effect on sub-barrier fusion. NUCLEAR REACTIONS 24,25,26Mg, 27Al(32,34S, Fusion) 0.9barrier parameters; discussed importance of zero point motion, static deformation, coupled channels effects on fusion process.

  11. A Theoretical Model for Predicting Residual Stress Generation in Fabrication Process of Double-Ceramic-Layer Thermal Barrier Coating System

    Science.gov (United States)

    Song, Yan; Wu, Weijie; Xie, Feng; Liu, Yilun; Wang, Tiejun

    2017-01-01

    Residual stress arisen in fabrication process of Double-Ceramic-Layer Thermal Barrier Coating System (DCL-TBCs) has a significant effect on its quality and reliability. In this work, based on the practical fabrication process of DCL-TBCs and the force and moment equilibrium, a theoretical model was proposed at first to predict residual stress generation in its fabrication process, in which the temperature dependent material properties of DCL-TBCs were incorporated. Then, a Finite Element method (FEM) has been carried out to verify our theoretical model. Afterwards, some important geometric parameters for DCL-TBCs, such as the thickness ratio of stabilized Zirconia (YSZ, ZrO2-8%Y2O3) layer to Lanthanum Zirconate (LZ, La2Zr2O7) layer, which is adjustable in a wide range in the fabrication process, have a remarkable effect on its performance, therefore, the effect of this thickness ratio on residual stress generation in the fabrication process of DCL-TBCs has been systematically studied. In addition, some thermal spray treatment, such as the pre-heating treatment, its effect on residual stress generation has also been studied in this work. It is found that, the final residual stress mainly comes from the cooling down process in the fabrication of DCL-TBCs. Increasing the pre-heating temperature can obviously decrease the magnitude of residual stresses in LZ layer, YSZ layer and substrate. With the increase of the thickness ratio of YSZ layer to LZ layer, magnitudes of residual stresses arisen in LZ layer and YSZ layer will increase while residual stress in substrate will decrease. PMID:28103275

  12. Advances in monitoring the human dimension of natural resource systems: an example from the Great Barrier Reef

    Science.gov (United States)

    Marshall, N. A.; Bohensky, E.; Curnock, M.; Goldberg, J.; Gooch, M.; Nicotra, B.; Pert, P.; Scherl, L. M.; Stone-Jovicich, S.; Tobin, R. C.

    2016-11-01

    The aim of this paper is to demonstrate the feasibility and potential utility of decision-centric social-economic monitoring using data collected from Great Barrier Reef (Reef) region. The social and economic long term monitoring program (SELTMP) for the Reef is a novel attempt to monitor the social and economic dimensions of social-ecological change in a globally and nationally important region. It represents the current status and condition of the major user groups of the Reef with the potential to simultaneously consider trends, interconnections, conflicts, dependencies and vulnerabilities. Our approach was to combine a well-established conceptual framework with a strong governance structure and partnership arrangement that enabled the co-production of knowledge. The framework is a modification of the Millennium Ecosystem Assessment and it was used to guide indicator choice. Indicators were categorised as; (i) resource use and dependency, (ii) ecosystem benefits and well-being, and (iii) drivers of change. Data were collected through secondary datasets where existing and new datasets were created where not, using standard survey techniques. Here we present an overview of baseline results of new survey data from commercial-fishers (n = 210), marine-based tourism operators (n = 119), tourists (n = 2877), local residents (n = 3181), and other Australians (n = 2002). The indicators chosen describe both social and economic components of the Reef system and represent an unprecedented insight into the ways in which people currently use and depend on the Reef, the benefits that they derive, and how they perceive, value and relate to the Reef and each other. However, the success of a program such as the SELTMP can only occur with well-translated cutting-edge data and knowledge that are collaboratively produced, adaptive, and directly feeds into current management processes. We discuss how data from the SELTMP have already been incorporated into Reef management decision

  13. A Theoretical Model for Predicting Residual Stress Generation in Fabrication Process of Double-Ceramic-Layer Thermal Barrier Coating System.

    Science.gov (United States)

    Song, Yan; Wu, Weijie; Xie, Feng; Liu, Yilun; Wang, Tiejun

    2017-01-01

    Residual stress arisen in fabrication process of Double-Ceramic-Layer Thermal Barrier Coating System (DCL-TBCs) has a significant effect on its quality and reliability. In this work, based on the practical fabrication process of DCL-TBCs and the force and moment equilibrium, a theoretical model was proposed at first to predict residual stress generation in its fabrication process, in which the temperature dependent material properties of DCL-TBCs were incorporated. Then, a Finite Element method (FEM) has been carried out to verify our theoretical model. Afterwards, some important geometric parameters for DCL-TBCs, such as the thickness ratio of stabilized Zirconia (YSZ, ZrO2-8%Y2O3) layer to Lanthanum Zirconate (LZ, La2Zr2O7) layer, which is adjustable in a wide range in the fabrication process, have a remarkable effect on its performance, therefore, the effect of this thickness ratio on residual stress generation in the fabrication process of DCL-TBCs has been systematically studied. In addition, some thermal spray treatment, such as the pre-heating treatment, its effect on residual stress generation has also been studied in this work. It is found that, the final residual stress mainly comes from the cooling down process in the fabrication of DCL-TBCs. Increasing the pre-heating temperature can obviously decrease the magnitude of residual stresses in LZ layer, YSZ layer and substrate. With the increase of the thickness ratio of YSZ layer to LZ layer, magnitudes of residual stresses arisen in LZ layer and YSZ layer will increase while residual stress in substrate will decrease.

  14. Survey and selection of Energy Storage System for Low Power Embedded System

    OpenAIRE

    Meenu Nair; Chandan Maity

    2012-01-01

    Energy storage for portable low power Embedded System is one of the biggest challenges for a long time operation in present research and application. These systems are designed to operate the lowest possible energy at micro-watt or Milli-Watt range and the power is supplied from a small primary or secondary cell. In this paper an extensive study and latest survey has been shown to estimate and select the right suitable energy storage device in theoretical aspects and also commercially availab...

  15. Computational design of nanoparticle drug delivery systems for selective targeting.

    Science.gov (United States)

    Duncan, Gregg A; Bevan, Michael A

    2015-10-01

    Ligand-functionalized nanoparticles capable of selectively binding to diseased versus healthy cell populations are attractive for improved efficacy of nanoparticle-based drug and gene therapies. However, nanoparticles functionalized with high affinity targeting ligands may lead to undesired off-target binding to healthy cells. In this work, Monte Carlo simulations were used to quantitatively determine net surface interactions, binding valency, and selectivity between targeted nanoparticles and cell surfaces. Dissociation constant, KD, and target membrane protein density, ρR, are explored over a range representative of healthy and cancerous cell surfaces. Our findings show highly selective binding to diseased cell surfaces can be achieved with multiple, weaker affinity targeting ligands that can be further optimized by varying the targeting ligand density, ρL. Using the approach developed in this work, nanomedicines can be optimally designed for exclusively targeting diseased cells and tissues.

  16. Selection of active elements in system reduction of vibration

    Science.gov (United States)

    Bialas, K.

    2016-11-01

    This work presents non-classical method of design of mechatronic systems. The purpose of this paper is also introduces synthesis of mechatronic system understand as design of mechatronic systems. The synthesis may be applied to modify the already existing systems in order to achieve a desired result. The system was consisted from mechanical and electrical elements. Electrical elements were used as subsystem reducing unwanted vibration of mechanical system. Electrical elements can be realized in the form of coils with movable core. The system was modelled in Matlab Simulink.

  17. The blood-brain barrier: an engineering perspective

    OpenAIRE

    Wong, Andrew D.; Ye, Mao; Levy, Amanda F.; Rothstein, Jeffrey D.; Bergles, Dwight E.; Searson, Peter C.

    2013-01-01

    It has been more than 100 years since Paul Ehrlich reported that various water-soluble dyes injected into the circulation did not enter the brain. Since Ehrlich's first experiments, only a small number of molecules, such as alcohol and caffeine have been found to cross the blood-brain barrier, and this selective permeability remains the major roadblock to treatment of many central nervous system diseases. At the same time, many central nervous system diseases are associated with disruption of...

  18. System Analysis of New Product Family Development Selection

    Institute of Scientific and Technical Information of China (English)

    ZHANG Kun

    2006-01-01

    This paper presents a new approach to the selection of new product family development. First, the factors are discussed that contribute to the new product family development. Due to the vagueness and uncertain existing in the factors, the fuzzy continue-semantic scale is introduced. Then, the fuzzy analytic hierarchy process (AHP) has been used in weighting the importance of the factors. Next, the fuzzy clustering method is applied to the selection of new product family developments. Lostly, one case is provided to illustrate the proposed approach.

  19. Tailoring NIST Security Controls for the Ground System: Selection and Implementation -- Recommendations for Information System Owners

    Science.gov (United States)

    Takamura, Eduardo; Mangum, Kevin

    2016-01-01

    . Certain protective measures for the general enterprise may not be as efficient within the ground segment. This is what the authors have concluded through observations and analysis of patterns identified from the various security assessments performed on NASA missions such as MAVEN, OSIRIS-REx, New Horizons and TESS, to name a few. The security audits confirmed that the framework for managing information system security developed by the National Institute of Standards and Technology (NIST) for the federal government, and adopted by NASA, is indeed effective. However, the selection of the technical, operational and management security controls offered by the NIST model - and how they are implemented - does not always fit the nature and the environment where the ground system operates in even though there is no apparent impact on mission success. The authors observed that unfit controls, that is, controls that are not necessarily applicable or sufficiently effective in protecting the mission systems, are often selected to facilitate compliance with security requirements and organizational expectations even if the selected controls offer minimum or non-existent protection. This paper identifies some of the standard security controls that can in fact protect the ground system, and which of them offer little or no benefit at all. It offers multiple scenarios from real security audits in which the controls are not effective without, of course, disclosing any sensitive information about the missions assessed. In addition to selection and implementation of controls, the paper also discusses potential impact of recent legislation such as the Federal Information Security Modernization Act (FISMA) of 2014 - aimed at the enterprise - on the ground system, and offers other recommendations to Information System Owners (ISOs).

  20. Establishment and Application of Early Warning System for Flood and Debris Flow Triggered by Rapid Erosion of Natural Barrier

    Science.gov (United States)

    Kaji, A.; Mizuno, H.; Yamakoshi, T.; Ishizuka, T.

    2012-04-01

    A large amount of mass of land from a mountain slides into a gorge and a river, depositing on the bed. The formation of such natural barrier provides a dam called "a natural dam", allowing water to accumulate in the upstream. People living in the downstream of basin are at risk of flood triggered by the dam break. Recently, many people have been at such risk emerged by earthquakes and heavy rainfall therefore they have been requesting to establish an early warning system for such flood risk. By analyzing the past case of the formations and the natural dam breaks in Japan, it was found that the surface flow on the natural dam eroded the deposition rapidly and the accumulated water and the deposition started to flow downstream in many cases. So that an alert should be issued by forecasting when the accumulated water in the upstream starts to flow on the deposition. In order to forecast the timing, we have to take into consideration of the difference between the water volume of flowing to the lake from the upstream basin and that of seeping into the deposition. Our final target is to develop a method for estimating the two previous quantities. In the first step, we report the result of analysis of the past cases in Japan. We focused on the two natural dams in the Yuhama village in Miyagi prefecture and in the Nagatono village in Nara prefecture. The natural dam in Yuhama village was formed by a deep-seated landslide triggered by the earthquake in 2008, and the natural dam in Nagatono was formed by a deep-seated landslide triggered by heavy rainfall in 2011. In the Yuhama case, the water level of the accumulated water had been rising until it reached to the top of the natural dam. In the Nagatono case, the water level had been rising during rainfall, however the water level had been dropping after the rainfall. The difference between the water volume of flowing in and that of flowing out from the natural dam caused the tendencies. We are going to analyze the soil

  1. Cognitive skill correlates of the automated pilot selection system

    NARCIS (Netherlands)

    Uitdewilligen, G.J.A.M.L.; de Voogt, A.

    2008-01-01

    Job sample approaches are amongst the best predictors for performance of ab initio pilots in flight school. The Royal Netherlands Air Force uses a simulator based assessment procedure to select pilot students, which is a relatively expensive method compared to general skill and ability tests. Theref

  2. Distributed User Selection in Network MIMO Systems with Limited Feedback

    KAUST Repository

    Elkhalil, Khalil

    2015-09-06

    We propose a distributed user selection strategy in a network MIMO setting with M base stations serving K users. Each base station is equipped with L antennas, where LM ≪ K. The conventional selection strategy is based on a well known technique called semi-orthogonal user selection when the zero-forcing beamforming (ZFBF) is adopted. Such technique, however, requires perfect channel state information at the transmitter (CSIT), which might not be available or need large feedback overhead. This paper proposes an alternative distributed user selection technique where each user sets a timer that is inversely proportional to his channel quality indicator (CQI), as a means to reduce the feedback overhead. The proposed strategy allows only the user with the highest CQI to respond with a feedback. Such technique, however, remains collision free only if the transmission time is shorter than the difference between the strongest user timer and the second strongest user timer. To overcome the situation of longer transmission times, the paper proposes another feedback strategy that is based on the theory of compressive sensing, where collision is allowed and all users encode their feedback information and send it back to the base-stations simultaneously. The paper shows that the problem can be formulated as a block sparse recovery problem which is agnostic on the transmission time, which makes it a good alternative to the timer approach when collision is dominant.

  3. An active and selective heterogeneous catalytic system for Michael addition

    Institute of Scientific and Technical Information of China (English)

    Hoda Keipour; Mohammad A. Khalilzadeh; Abolfazl Hosseini; Afsaneh Pilevar; Daryoush Zareyee

    2012-01-01

    Potassium fluoride doped natural zeolite was found to be an efficient and selective solid base catalyst for 1,4-Michael addition.The catalyst is easily prepared and the workup procedure simplified by simple filtration.All products were obtained in high yields as well as short reaction times.

  4. State-Selective Excitation of Quantum Systems via Geometrical Optimization.

    Science.gov (United States)

    Chang, Bo Y; Shin, Seokmin; Sola, Ignacio R

    2015-09-08

    We lay out the foundations of a general method of quantum control via geometrical optimization. We apply the method to state-selective population transfer using ultrashort transform-limited pulses between manifolds of levels that may represent, e.g., state-selective transitions in molecules. Assuming that certain states can be prepared, we develop three implementations: (i) preoptimization, which implies engineering the initial state within the ground manifold or electronic state before the pulse is applied; (ii) postoptimization, which implies engineering the final state within the excited manifold or target electronic state, after the pulse; and (iii) double-time optimization, which uses both types of time-ordered manipulations. We apply the schemes to two important dynamical problems: To prepare arbitrary vibrational superposition states on the target electronic state and to select weakly coupled vibrational states. Whereas full population inversion between the electronic states only requires control at initial time in all of the ground vibrational levels, only very specific superposition states can be prepared with high fidelity by either pre- or postoptimization mechanisms. Full state-selective population inversion requires manipulating the vibrational coherences in the ground electronic state before the optical pulse is applied and in the excited electronic state afterward, but not during all times.

  5. Multi-criteria analysis on how to select solar radiation hydrogen production system

    Energy Technology Data Exchange (ETDEWEB)

    Badea, G.; Naghiu, G. S., E-mail: naghiu.george@gmail.com; Felseghi, R.-A.; Giurca, I., E-mail: giurca-ioan@yahoo.com [Technical University of Cluj-Napoca, Faculty of Building Services Engineering, Boulevard December 21, no. 128-130, Cluj-Napoca, 400604 (Romania); Răboacă, S. [National R& D Institute for Cryogenic and Isotopic Technologies, str. Uzinei, no. 4, Rm. Vălcea, 240050 (Romania); Aşchilean, I. [SC ACI Cluj SA, Avenue Dorobanţilor, no. 70, Cluj-Napoca, 400609 (Romania)

    2015-12-23

    The purpose of this article is to present a method of selecting hydrogen-production systems using the electric power obtained in photovoltaic systems, and as a selecting method, we suggest the use of the Advanced Multi-Criteria Analysis based on the FRISCO formula. According to the case study on how to select the solar radiation hydrogen production system, the most convenient alternative is the alternative A4, namely the technical solution involving a hydrogen production system based on the electrolysis of water vapor obtained with concentrated solar thermal systems and electrical power obtained using concentrating photovoltaic systems.

  6. Multi-criteria analysis on how to select solar radiation hydrogen production system

    Science.gov (United States)

    Badea, G.; Naghiu, G. S.; Felseghi, R.-A.; Rǎboacǎ, S.; Aşchilean, I.; Giurca, I.

    2015-12-01

    The purpose of this article is to present a method of selecting hydrogen-production systems using the electric power obtained in photovoltaic systems, and as a selecting method, we suggest the use of the Advanced Multi-Criteria Analysis based on the FRISCO formula. According to the case study on how to select the solar radiation hydrogen production system, the most convenient alternative is the alternative A4, namely the technical solution involving a hydrogen production system based on the electrolysis of water vapor obtained with concentrated solar thermal systems and electrical power obtained using concentrating photovoltaic systems.

  7. A CLIPS-based expert system for the evaluation and selection of robots

    Science.gov (United States)

    Nour, Mohamed A.; Offodile, Felix O.; Madey, Gregory R.

    1994-01-01

    This paper describes the development of a prototype expert system for intelligent selection of robots for manufacturing operations. The paper first develops a comprehensive, three-stage process to model the robot selection problem. The decisions involved in this model easily lend themselves to an expert system application. A rule-based system, based on the selection model, is developed using the CLIPS expert system shell. Data about actual robots is used to test the performance of the prototype system. Further extensions to the rule-based system for data handling and interfacing capabilities are suggested.

  8. Expression of Astrocytic Type 2 Angiotensin Receptor in Central Nervous System Inflammation Correlates With Blood-Brain Barrier Breakdown

    DEFF Research Database (Denmark)

    Füchtbauer, Laila; Toft-Hansen, Henrik; Khorooshi, Reza;

    2010-01-01

    is involved during BBB breakdown. We studied the type 2 angiotensin receptor AT(2) because of its suggested neuroprotective role. Two models of brain inflammation were used to distinguish solute versus cellular barrier functions. Both leukocytes and horseradish peroxidase (HRP) accumulated in the perivascular...

  9. Hanford Permanent Isolation Barrier Program: Asphalt technology development

    Energy Technology Data Exchange (ETDEWEB)

    Freeman, H.D.; Romine, R.A.

    1994-11-01

    An important component of the Hanford Permanent Isolation Barrier is the use of a two-layer composite asphalt system, which provides backup water diversion capabilities if the primary capillary barrier fails to meet infiltration goals. Because of asphalt`s potential to perform to specification over the 1000-year design life criterion, a composite asphalt barrier (HMAC/fluid-applied polymer-modified asphalt) is being considered as an alternative to the bentonite clay/high density poly(ethylene) barriers for the low-permeability component of the Hanford Permanent Isolation Barrier. The feasibility of using asphalt as a long-term barrier is currently being studied. Information that must be known is the ability of asphalt to retain desirable physical properties over a period of 1000 years. This paper presents the approach for performing accelerated aging tests and evaluating the performance of samples under accelerated conditions. The results of these tests will be compared with asphalt artifact analogs and the results of modeling the degradation of the selected asphalt composite to make life-cycle predictions.

  10. Resolution analyses for selecting an appropriate airborne electromagnetic (AEM) system

    DEFF Research Database (Denmark)

    Christensen, N.B.; Lawrie, Ken

    2012-01-01

    Abstract. The choice of an appropriate airborne electromagnetic system for a given task should be based on a comparative analysis of candidate systems, consisting of both theoretical considerations and field studies including test lines. It has become common practice to quantify the system...

  11. Partner Selection Analysis and System Development Based on Gray Relation Analysis for an Agile Virtual Enterprise

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    This paper analyzes the state of the art of partner selection and enumerates the advantage of partner selection based on gray relation analysis comparing to the other algorithms of the partner selection. Furthermore, partner selection system based on gray relation for an Agile Virtual Enterprise(AVE) is analyzed and designed based on the definition and characteristics of the AVE. According to J2EE mode, the architecture of the partner selection system is put forward and the system is developed using JSP, EJB and SQL Server. The paper lays emphasis on a gray relational mathematic model, AVE evaluation infrastructure, a core algorithm of partner selection and a multi-layer gray relation selection process.

  12. Selection of probability based weighting models for Boolean retrieval system

    Energy Technology Data Exchange (ETDEWEB)

    Ebinuma, Y. (Japan Atomic Energy Research Inst., Tokai, Ibaraki. Tokai Research Establishment)

    1981-09-01

    Automatic weighting models based on probability theory were studied if they can be applied to boolean search logics including logical sum. The INIS detabase was used for searching of one particular search formula. Among sixteen models three with good ranking performance were selected. These three models were further applied to searching of nine search formulas in the same database. It was found that two models among them show slightly better average ranking performance while the other model, the simplest one, seems also practical.

  13. A dynamic data source selection system for smartwatch platform.

    Science.gov (United States)

    Nemati, Ebrahim; Sideris, Konstantinos; Kalantarian, Haik; Sarrafzadeh, Majid

    2016-08-01

    A novel data source selection algorithm is proposed for ambulatory activity tracking of elderly people. The algorithm introduces the concept of dynamic switching between the data collection modules (a smartwatch and a smartphone) to improve accuracy and battery life using contextual information. We show that by making offloading decisions as a function of activity, the proposed algorithm improves power consumption and accuracy of the previous work by 7 hours and 5% respectively compared to the baseline.

  14. Search and selection hotel system in Surabaya based on geographic information system (GIS) with fuzzy logic

    Science.gov (United States)

    Purbandini, Taufik

    2016-03-01

    Surabaya is a metropolitan city in Indonesia. When the visitor has an interest in Surabaya for several days, then the visitor was looking for lodging that is closest to the interests of making it more efficient and practical. It was not a waste of time for the businessman because of congestion and so we need full information about the hotel as an inn during a stay in Surabaya began name, address of the hotel, the hotel's website, the distance from the hotel to the destination until the display of the map along the route with the help of Google Maps. This system was designed using fuzzy logic which aims to assist the user in making decisions. Design of hotel search and selection system was done through four stages. The first phase was the collection of data and as the factors that influence the decision-making along with the limit values of these factors. Factors that influence covers a distance of the hotel, the price of hotel rooms, and hotel reviews. The second stage was the processing of data and information by creating membership functions. The third stage was the analysis of systems with fuzzy logic. The steps were performed in systems analysis, namely fuzzification, inference using Mamdani, and defuzzification. The last stage was the design and construction of the system. Designing the system using use case diagrams and activity diagram to describe any process that occurs. Development system includes system implementation and evaluation systems. Implementation of mobile with Android-based system so that these applications were user friendly.

  15. Yttria-stabilized zirkonia / gadolinium zirconate double-layer plasma-sprayed thermal barrier coating systems (TBCs)

    Energy Technology Data Exchange (ETDEWEB)

    Bakan, Emine

    2015-07-01

    Thermal barrier coating (TBC) research and development is driven by the desirability of further increasing the maximum inlet temperature in a gas turbine engine. A number of new top coat ceramic materials have been proposed during the last decades due to limited temperature capability (1200 C) of the state-of-the-art yttria-stabilized zirconia (7 wt. % Y{sub 2}O{sub 3}-ZrO{sub 2}, YSZ) at long term operation. Zirconate pyrochlores of the large lanthanides((Gd → La){sub 2}Zr{sub 2}O{sub 7}) have been particularly attractive due to their higher temperature phase stability than that of the YSZ. Nonetheless, the issues related with the implementation of pyrochlores such as low fracture toughness and formation of deleterious interphases with thermally grown oxide (TGO, Al{sub 2}O{sub 3}) were reported. The implication was the requirement of an interlayer between the pyrochlores and TGO, which introduced double-layer systems to the TBC literature. Furthermore, processability issues of pyrochlores associated with the different evaporation rates of lanthanide oxides and zirconia resulting in unfavorable composition variations in the coatings were addressed in different studies. After all, although the material properties are available, there is a paucity of data in the literature concerning the properties of the coatings made of pyrochlores. From the processability point of view the most reported pyrochlore is La{sub 2}Zr{sub 2}O{sub 7}. Hence, the goal of this research was to investigate plasma-sprayed Gd{sub 2}Zr{sub 2}O{sub 7} (GZO) coatings and YSZ/GZO double-layer TBC systems. Three main topics were examined based on processing, performance and properties: (i) the plasma spray processing of the GZO and its impact on the microstructural and compositional properties of the GZO coatings; (ii) the cycling lifetime of the YSZ/GZO double-layer systems under thermal gradient at a surface temperature of 1400 C; (iii) the properties of the GZO and YSZ coatings such as

  16. Approaches to formalization of the informal waste sector into municipal solid waste management systems in low- and middle-income countries: Review of barriers and success factors

    DEFF Research Database (Denmark)

    Aparcana Robles, Sandra Roxana

    2016-01-01

    , this paper aims to address this gap by explaining to policy- and decision-makers, and to waste managers in the private sector, certain dynamics that can be observed and that should be taken into account when designing formalization strategies that are adapted to their particular socioeconomic and political......The Municipal Solid Waste Management (MSWM) sector represents a major challenge for low-and middle-income countries due to significant environmental and socioeconomic issues involving rapid urbanization, their MSWM systems, and the existence of the informal waste sector. Recognizing its role...... on the assessment, the paper discussed possible links between formalization approaches and barriers, the 'persistent' challenges that represent barriers to formalization, as well as key enabling factors improving the likelihood of successful formalization. Regardless of the type of approach adopted to formalization...

  17. Methodology for Selection of Non-Restored Reserved Systems Pertaining to Control of Technological Processes

    Directory of Open Access Journals (Sweden)

    V. A. Anischenko

    2008-01-01

    Full Text Available The paper contains analysis of reliability of non-restored passive reserved systems pertaining to control of technological processes. Criteria have been justified and methodology for optimum selection of reserved systems has been developed.

  18. Implementations of advisory system for the solvent selection of carbon dioxide removal processes

    Energy Technology Data Exchange (ETDEWEB)

    Chan, C.; Lau, P. [Regina Univ., SK (Canada)

    1997-12-31

    The Solvent Selection Advisory System (SSAS) is a decision support system for aiding users in the preliminary selection of optimal solvents for carbon dioxide removal processes given different user specification and plant conditions. This paper describes an inference-network representation of the Solvent Selection Advisory System which has been previously implemented as a rule-based system. Two expert system shells, G2 and GDA from Gensym Corp. are used, and the implementations on a two shell are compared. Some advantages and disadvantages in the two representation approaches are discussed. (Author)

  19. Implementation of renewable energy technology - Opportunities and barriers. Summary of country studies

    Energy Technology Data Exchange (ETDEWEB)

    Painuly, J.P.; Fenhann, J.V.

    2002-07-01

    The project was launched to identify barriers to the implementation of renewable energy technologies (RETs) and explore measures to overcome the identified barriers. National institutions in Egypt, Ghana and Zimbabwe carried out the country studies based on the basic methodological framework provided by the UNEP Centre. The objectives of the project included strengthening institutional capacity for analysis and implementation of RET projects in the participating countries and bring out experiences on RETs barriers and removal measures for dissemination so that others can benefit from the knowledge so gained. An important highlight of the studies was involvement of stake holders in the process of identification of barriers and measures to remove them. A preliminary identification of relevant RETs for their countries was done by the country teams in the initial stage of the project. After that, national workshops involving various stake holders were held between July and September 1999 to discuss the RETs and barriers to their implementation. Based on the discussions, a few important RETs were identified for more detailed study. PV systems for rural electrification, solar water heating systems and large-scale biogas system were identified and analysed for barriers in the Egypt country study. Economic, information and policy barriers were identified as major barriers for these technologies. Solar water pumps, biogas and small hydro were the focus of study in Ghana. In this case also, economic, information and policy barriers were found to be the important barriers for the selected technologies. In the case of Zimbabwe, focus was on identification of primary and secondary barriers to RETs dissemination. The primary barriers included lack of capacity to develop proposals, lack of information for policy making and framework for information dissemination. The study concluded that the secondary barriers as seen and experienced by the stake holders are due to primary

  20. Evaluation of Neighbourhood Selection Methods in Decentralized Recommendation Systems

    NARCIS (Netherlands)

    Clements, M.; Vries, A.P. de; Pouwelse, J.A.; Wang, J.; Reinders, M.J.T.

    2007-01-01

    Recommendation systems are important in social networks that allow the injection of user-generated content and let users indicate their preferences towards the content introduced by others. Considering the increase of usage of these collaborative systems, it seems only a matter of time before the cu

  1. Information systems planning methodologies: a framework for comparison and selection

    OpenAIRE

    Steffensen, Robert E.

    1991-01-01

    Approved for public release; distribution is unlimited The success of organizational information systems (IS) depends largely upon effective planning for the information systems. A comprehensive IS plan should provide a coordinated approach to strategic business goals, organizational information requirements and an overall measure of performance. Acknowledging the importance of comprehensive planning in the process of managing the organization's information resource, a collection of meth...

  2. Adding value to innovation : Impressionism and the transformation of the selection system in visual arts

    NARCIS (Netherlands)

    Wijnberg, NM; Gemser, G

    2000-01-01

    Valuation of cultural products tends to be problematic. In this paper, we provide insight into how valuation of cultural products takes place by describing the changing role and significance of different types of selection systems. Three basic types of selection systems are distinguished: market sel

  3. Selecting a Web Content Management System for an Academic Library Website

    OpenAIRE

    Elizabeth L. Black

    2011-01-01

    This article describes the selection of a web content management system (CMS) at the Ohio State University Libraries. The author outlines the need for a CMS, describes the system requirements to support a large distributed content model and shares the CMS trial method used, which directly included content provider feedback side-by-side with the technical experts. The selected CMS is briefly described.

  4. Clonal Selection Based Artificial Immune System for Generalized Pattern Recognition

    Science.gov (United States)

    Huntsberger, Terry

    2011-01-01

    The last two decades has seen a rapid increase in the application of AIS (Artificial Immune Systems) modeled after the human immune system to a wide range of areas including network intrusion detection, job shop scheduling, classification, pattern recognition, and robot control. JPL (Jet Propulsion Laboratory) has developed an integrated pattern recognition/classification system called AISLE (Artificial Immune System for Learning and Exploration) based on biologically inspired models of B-cell dynamics in the immune system. When used for unsupervised or supervised classification, the method scales linearly with the number of dimensions, has performance that is relatively independent of the total size of the dataset, and has been shown to perform as well as traditional clustering methods. When used for pattern recognition, the method efficiently isolates the appropriate matches in the data set. The paper presents the underlying structure of AISLE and the results from a number of experimental studies.

  5. Emergency remediation measures of a hydroxyisobutyronitrile spill using hydraulic and hydrochemical barriers and pump and treat system (Rho area-Milan, Italy)

    Energy Technology Data Exchange (ETDEWEB)

    Avanzini, M.; Nespoli, M.; Pagotto, A. [EG Engenireeing Geology, Milano (Italy); Peretta, G.P. [Torino Univ. (Italy). Dipt. di Scienze della Terra

    1998-12-31

    The paper deals about emergency clean-up measures after an accidental contamination by hydroxyisobutyronitrile (acetone cyanohydrin) occurred in a aquifer in the industrial area of ELF-ATOCHEM in Rho (province of Milan). Site investigations and tests carried out for planning barrier wells lay-out, injection wells of hydrogen peroxide and in situ treatment of contaminated soil are illustrated. This combined measures system allowed to obtain a high efficacy in pollutant removal in accordance to the Authority`s requests. The final goal of the remediation system activity was reached fifteen months later: concentrations measured at monitoring wells showed values compatible with standards for drinking water quality.

  6. Diagnosing Hybrid Systems: a Bayesian Model Selection Approach

    Science.gov (United States)

    McIlraith, Sheila A.

    2005-01-01

    In this paper we examine the problem of monitoring and diagnosing noisy complex dynamical systems that are modeled as hybrid systems-models of continuous behavior, interleaved by discrete transitions. In particular, we examine continuous systems with embedded supervisory controllers that experience abrupt, partial or full failure of component devices. Building on our previous work in this area (MBCG99;MBCG00), our specific focus in this paper ins on the mathematical formulation of the hybrid monitoring and diagnosis task as a Bayesian model tracking algorithm. The nonlinear dynamics of many hybrid systems present challenges to probabilistic tracking. Further, probabilistic tracking of a system for the purposes of diagnosis is problematic because the models of the system corresponding to failure modes are numerous and generally very unlikely. To focus tracking on these unlikely models and to reduce the number of potential models under consideration, we exploit logic-based techniques for qualitative model-based diagnosis to conjecture a limited initial set of consistent candidate models. In this paper we discuss alternative tracking techniques that are relevant to different classes of hybrid systems, focusing specifically on a method for tracking multiple models of nonlinear behavior simultaneously using factored sampling and conditional density propagation. To illustrate and motivate the approach described in this paper we examine the problem of monitoring and diganosing NASA's Sprint AERCam, a small spherical robotic camera unit with 12 thrusters that enable both linear and rotational motion.

  7. Some methods to regulate low-bias negative differential resistance in σ barrier separating nanoscale molecular transport systems

    Science.gov (United States)

    Shen, Ji-Mei; Liu, Jing; Min, Yi; Zhou, Li-Ping

    2016-12-01

    Using the first-principles method which combines the nonequilibrium Green’s function (NEGF) with density functional theory (DFT), the role of defect, dopant, barrier length and geometric deformation for low-bias negative differential resistance (NDR) in two capped armchair carbon nanotubes (CNTs) sandwiching σ barrier are systematically analyzed. We found that this method can regulate the negative differential resistance (NDR) effects such as current peak and peak position. The adjusting mechanism may originate from orbital interaction and orbital reconstruction. Our calculations try to manipulate the transport characteristics in energy space by simply manipulating the structure in real space, which may promise the potential applications in nanomolecular-electronics in the future.

  8. Linear response of a pre- and post-selected system to an external field

    Energy Technology Data Exchange (ETDEWEB)

    Ban, Masashi, E-mail: ban.masashi@ocha.ac.jp

    2015-02-06

    Linear response to an external field is studied for a quantum system with pre- and post-selection. Effects of an external field on strong and weak values of a system observable are found. The external field applied after the measurement of the observable influences the linear response of the system through post-selection. A time-symmetric property in the linear response is found. - Highlights: • The linear response theory is applied to a quantum system with pre-selection and post-selection. • It is found how an external field affects strong and weak values of a measured system observable • Not only an external field before measurement but also one after measurement influences the linear response due to the post-selection.

  9. PD Controller Structures: Comparison and Selection for an Electromechanical System

    Directory of Open Access Journals (Sweden)

    Farhan A. Salem

    2015-01-01

    Full Text Available Many different PD controller modeling, configurations and control algorithms have been developed. These methods differ in their theoretical basis and performance under the changes of system conditions. In the present paper we review the methods used in the design of PD control systems. We highlight the main difficulties and summarize the more recent developments in their control techniques. Intelligent control systems like PD fuzzy control can be used to emulate the qualitative aspects of human knowledge with several advantages such as universal approximation theorem and rule-based algorithms.

  10. Road Safety Barriers, the Need and Influence on Road Traffic Accidents

    Science.gov (United States)

    Butāns, Ž.; Gross, K. A.; Gridnevs, A.; Karzubova, E.

    2015-11-01

    Constantly increasing intensity of road traffic and the allowed speed limits seem to impose stronger requirements on road infrastructure and use of road safety systems. One of the ways to improve road safety is the use of road restraint systems. Road safety barriers allow not only reducing the number of road traffic accidents, but also lowering the severity of accidents. The paper provides information on the technical requirements of road safety barriers. Various types of road safety barriers and their selection criteria for different types of road sections are discussed. The article views an example of a road traffic accident, which is also modelled by PC-Crash computer program. The given example reflects a road accident mechanism in case of a car-to-barrier collision, and provides information about the typical damage to the car and the barrier. The paper describes an impact of the road safety barrier type and its presence on the road traffic accident mechanism. Implementation and maintenance costs of different barrier types are viewed. The article presents a discussion on the necessity to use road safety barriers, as well as their optimal choice.

  11. Perception of community pharmacists towards the barriers to enhanced pharmacy services in the healthcare system of Dubai: a quantitative approach

    Directory of Open Access Journals (Sweden)

    Rayes IK

    2015-06-01

    Full Text Available Background: In many developing countries, pharmacists are facing many challenges while they try to enhance the quality of services provided to patients approaching community pharmacies. Objective: To explore perception of community pharmacists in Dubai regarding the obstacles to enhanced pharmacy services using a part of the results from a nation-wide quantitative survey. Methods: A questionnaire was distributed to 281 full-time licensed community pharmacists in Dubai. The questionnaire had 5 inter-linked sections: demographic information, information about the pharmacy, interaction with physicians, pharmacists’ current professional role, and barriers to enhanced pharmacy services. Results: About half of the respondents (45.4%, n=90 agreed that pharmacy clients under-estimate them and 52.5% (n=104 felt the same by physicians. About 47.5% (n=94 of the respondents felt that they are legally unprotected against profession’s malpractice. Moreover, 64.7% (n=128 stated that pharmacy practice in Dubai turned to be business-focused. In addition, 76.8% (n=252 found that one of the major barriers to enhanced pharmacy services is the high business running cost. Pharmacists screened tried to prove that they are not one of the barriers to optimized pharmacy services as 62.7% (n=124 disagreed that they lack appropriate knowledge needed to serve community and 67.7% (n=134 gave the same response when asked whether pharmacy staff lack confidence when treating consumers or not. Conclusions: Although being well established within the community, pharmacists in Dubai negatively perceived their own professional role. They stated that there are number of barriers which hinder optimized delivery of pharmacy services like under-estimation by pharmacy clients and other healthcare professionals, pressure to make sales, and high running cost.

  12. Selected Methods For Increases Reliability The Of Electronic Systems Security

    Directory of Open Access Journals (Sweden)

    Paś Jacek

    2015-11-01

    Full Text Available The article presents the issues related to the different methods to increase the reliability of electronic security systems (ESS for example, a fire alarm system (SSP. Reliability of the SSP in the descriptive sense is a property preservation capacity to implement the preset function (e.g. protection: fire airport, the port, logistics base, etc., at a certain time and under certain conditions, e.g. Environmental, despite the possible non-compliance by a specific subset of elements this system. Analyzing the available literature on the ESS-SSP is not available studies on methods to increase the reliability (several works similar topics but moving with respect to the burglary and robbery (Intrusion. Based on the analysis of the set of all paths in the system suitability of the SSP for the scenario mentioned elements fire events (device critical because of security.

  13. Advanced Turbine System Program: Phase 2 cycle selection

    Energy Technology Data Exchange (ETDEWEB)

    Latcovich, J.A. Jr. [ABB Power Generation, Inc., Midlothian, VA (United States)

    1995-10-01

    The objectives of the Advanced Turbine System (ATS) Phase 2 Program were to define a commercially attractive ATS cycle and to develop the necessary technologies required to meet the ATS Program goals with this cycle. This program is part of an eight-year Department of Energy, Fossil Energy sponsored ATS Program to make a significant improvement in natural gas-fired power generation plant efficiency while providing an environmentally superior and cost-effective system.

  14. ERP Systems: How Hard Can It Be to Select One?

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ A $500 million distributor has a 15-year-old ERP system nearing the end of its usefulness.While last year's recession tabled plans to replace it,senior business leaders have now resurrected the idea.They've asked the CIO to find an ERP system that can be implemented"quickly and cost-effectively."What steps should this CIO take to ensure success?

  15. Selection of a Relevant In Vitro Blood-Brain Barrier Model to Investigate Pro-Metastatic Features of Human Breast Cancer Cell Lines.

    Science.gov (United States)

    Drolez, Aurore; Vandenhaute, Elodie; Julien, Sylvain; Gosselet, Fabien; Burchell, Joy; Cecchelli, Roméo; Delannoy, Philippe; Dehouck, Marie-Pierre; Mysiorek, Caroline

    2016-01-01

    Around 7-17% of metastatic breast cancer patients will develop brain metastases, associated with a poor prognosis. To reach the brain parenchyma, cancer cells need to cross the highly restrictive endothelium of the Blood-Brain Barrier (BBB). As treatments for brain metastases are mostly inefficient, preventing cancer cells to reach the brain could provide a relevant and important strategy. For that purpose an in vitro approach is required to identify cellular and molecular interaction mechanisms between breast cancer cells and BBB endothelium, notably at the early steps of the interaction. However, while numerous studies are performed with in vitro models, the heterogeneity and the quality of BBB models used is a limitation to the extrapolation of the obtained results to in vivo context, showing that the choice of a model that fulfills the biological BBB characteristics is essential. Therefore, we compared pre-established and currently used in vitro models from different origins (bovine, mice, human) in order to define the most appropriate tool to study interactions between breast cancer cells and the BBB. On each model, the BBB properties and the adhesion capacities of breast cancer cell lines were evaluated. As endothelial cells represent the physical restriction site of the BBB, all the models consisted of endothelial cells from animal or human origins. Among these models, only the in vitro BBB model derived from human stem cells both displayed BBB properties and allowed measurement of meaningful different interaction capacities of the cancer cell lines. Importantly, the measured adhesion and transmigration were found to be in accordance with the cancer cell lines molecular subtypes. In addition, at a molecular level, the inhibition of ganglioside biosynthesis highlights the potential role of glycosylation in breast cancer cells adhesion capacities.

  16. DSP4, a selective neurotoxin for the locus coeruleus noradrenergic system. A review of its mode of action.

    Science.gov (United States)

    Ross, Svante B; Stenfors, Carina

    2015-01-01

    DSP4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride) is a selective neurotoxin for the locus coeruleus noradrenergic system in the rodent and bird brain. It readily passes the blood-brain barrier and cyclizes to a reactive aziridinium derivative that is accumulated into the noradrenergic nerve terminals via the noradrenaline transporter. DSP4 is also an irreversible inhibitor of this transporter. Within the nerve terminals the aziridinium derivative reacts with unknown vital cellular components, destroying the terminals. At the dose 50 mg/kg i.p. this is characterized by a rapid and long-lasting loss of noradrenaline and a slower decrease in the dopamine-β-hydroxylase enzyme activity and immunoreactivity in the regions innervated from locus coeruleus. The tissue level of noradrenaline is reduced to 10-30% of the normal value. The extraneuronal concentration is, on the other hand, increased due to inflow from non-lesioned regions. Like the peripheral sympathetic nerves the non-locus coeruleus noradrenergic systems in the rodent brain is resistant to the neurotoxic action of DSP4. Serotoninergic and dopaminergic nerves are only slightly or not at all affected by DSP4. The neurotoxic effect is counteracted by pretreatment with noradrenaline uptake inhibitors (e.g., desipramine). MAO-B inhibitors of the N-propargylamine type (e.g., selegiline) also counteract the DSP4-induced neurotoxicity with another, yet unknown mechanism. Because of its selectivity for the locus coeruleus system DSP4 is a useful tool in studies of the functional role of this noradrenergic system in the brain.

  17. An Antibiotic Selection System For Protein Overproducing Bacteria

    DEFF Research Database (Denmark)

    Rennig, Maja; Nørholm, Morten

    2015-01-01

    Introduction: Protein overproduction is a major bottleneck for analyses of membrane proteins and for the construction of cell factories. Screening for optimized protein production can be very time consuming. In this study we show that the coupling of antibiotic resistance to poorly produced...... that translationally couples the genes. Consequently, high expressing gene variants also allow for higher production of the coupled antibiotic resistance marker. Therefore, high expressing gene variants in a library can be determined either by plating the expression library on selection plates or by growing...... the library in a liquid culture, while both contain high concentrations of the inducible antibiotic.Results: We designed libraries for membrane proteins of E. coli, based on a recently published technique that promises enhanced protein production by optimizing the nucleotides between the Shine Dalgarno...

  18. Electromagnetic waves in complex systems selected theoretical and applied problems

    CERN Document Server

    Velychko, Lyudmyla

    2016-01-01

    This book gives guidance to solve problems in electromagnetics, providing both examples of solving serious research problems as well as the original results to encourage further investigations. The book contains seven chapters on various aspects of resonant wave scattering, each solving one original problem. All of them are unified by the authors’ desire to show advantages of rigorous approaches at all stages, from the formulation of a problem and the selection of a method to the interpretation of results. The book reveals a range of problems associated with wave propagation and scattering in natural and artificial environments or with the design of antennas elements. The authors invoke both theoretical (analytical and numerical) and experimental techniques for handling the problems. Attention is given to mathematical simulations, computational efficiency, and physical interpretation of the experimental results. The book is written for students, graduate students and young researchers. .

  19. Non-antibiotic selection systems for soybean somatic embryos: the lysine analog aminoethyl-cysteine as a selection agent

    Directory of Open Access Journals (Sweden)

    Kwanyuen Prachuab

    2009-11-01

    Full Text Available Abstract Background In soybean somatic embryo transformation, the standard selection agent currently used is hygromycin. It may be preferable to avoid use of antibiotic resistance genes in foods. The objective of these experiments was to develop a selection system for producing transgenic soybean somatic embryos without the use of antibiotics such as hygromycin. Results When tested against different alternate selection agents our studies show that 0.16 μg/mL glufosinate, 40 mg/L isopropylamine-glyphosate, 0.5 mg/mL (S-(2 aminoethyl-L-cysteine (AEC and the acetolactate synthase (ALS inhibitors Exceed® and Synchrony® both at 150 μg/mL inhibited soybean somatic embryo growth. Even at the concentration of 2 mg/mL, lysine+threonine (LT were poor selection agents. The use of AEC may be preferable since it is a natural compound. Unlike the plant enzyme, dihydrodipicolinate synthase (DHPS from E. coli is not feed-back inhibited by physiological concentrations of lysine. The dapA gene which codes for E. coli DHPS was expressed in soybean somatic embryos under the control of the CaMV 35S promoter. Following introduction of the construct into embryogenic tissue of soybean, transgenic events were recovered by incubating the tissue in liquid medium containing AEC at a concentration of 5 mM. Only transgenic soybeans were able to grow at this concentration of AEC; no escapes were observed. Conclusion Genetically engineered soybeans expressing a lysine insensitive DHPS gene can be selected with the non-antibiotic selection agent AEC. We also report here the inhibitory effects of glufosinate, (isopropylamine-glyphosate (Roundup®, AEC and the ALS inhibitors Exceed® and Synchrony® against different tissues of soybean

  20. Enhancing the Systems Decision Process with Flexibility Analysis for Optimal Unmanned Aircraft System Selection

    Science.gov (United States)

    2008-06-01

    makeholders are responsibln the for makingll, UAS studieds at reseach decisionh. gate owndesribe d bi payer is the SLC. The systatem engineer uses...barrier because the majority of the companies were vying for a share of the same market space. As a result, concerns over proprietary intelligence prevented

  1. Selected legal and regulatory concerns affecting domestic energy transportation systems

    Energy Technology Data Exchange (ETDEWEB)

    Schuller, C.R.

    1979-07-01

    This report provides assessments of eight legal and regulatory concerns that may affect energy material transportation in the US during the rest of the century: state authority to regulate nuclear materials transport, divestiture of petroleum pipelines from major integrated oil companies, problems affecting the natural gas transportation system, capabilities of energy transportation systems during emergencies, Federal coal pipeline legislation, ability of Federal agencies to anticipate railroad difficulties, abandonment of uneconomic railroad lines, and impact of the Panama Canal treaty upon US energy transportation. (DLC)

  2. Radio access selection in multi-radio access systems

    NARCIS (Netherlands)

    Jorgušeski, L.; Litjens, R.; Zhiyi, C.; Nikookar, H.

    2007-01-01

    Future wireless access systems will be characterized by their heterogeneity from technological point of view. It is envisaged that in certain areas end-users will have a choice between various radio accesses (RAs) such as e.g. classical cellular networks (GSM, UMTS, WiMAX, etc), WLAN hot-spots, or o

  3. Selected Topics on Information Systems Engineering: Editorial Introduction to Issue 9 of CSIMQ

    Directory of Open Access Journals (Sweden)

    Sergio Espana

    2016-12-01

    Full Text Available This issue of the journal of Complex Systems Informatics and Modeling (CSIMQ presents papers that discuss selected topics on information systems engineering. The papers are extended versions of selected papers from the CAiSE Forum 2016 held in Ljubljana, Slovenia. The CAiSE Forum is a place within the International Conference on Advanced Information Systems Engineering for disseminating and debating new ideas and tools related to this area.

  4. Variable selection in identification of a high dimensional nonlinear non-parametric system

    Institute of Scientific and Technical Information of China (English)

    Er-Wei BAI; Wenxiao ZHAO; Weixing ZHENG

    2015-01-01

    The problem of variable selection in system identification of a high dimensional nonlinear non-parametric system is described. The inherent difficulty, the curse of dimensionality, is introduced. Then its connections to various topics and research areas are briefly discussed, including order determination, pattern recognition, data mining, machine learning, statistical regression and manifold embedding. Finally, some results of variable selection in system identification in the recent literature are presented.

  5. Knowledge-Based, Central Nervous System (CNS) Lead Selection and Lead Optimization for CNS Drug Discovery.

    Science.gov (United States)

    Ghose, Arup K; Herbertz, Torsten; Hudkins, Robert L; Dorsey, Bruce D; Mallamo, John P

    2012-01-18

    The central nervous system (CNS) is the major area that is affected by aging. Alzheimer's disease (AD), Parkinson's disease (PD), brain cancer, and stroke are the CNS diseases that will cost trillions of dollars for their treatment. Achievement of appropriate blood-brain barrier (BBB) penetration is often considered a significant hurdle in the CNS drug discovery process. On the other hand, BBB penetration may be a liability for many of the non-CNS drug targets, and a clear understanding of the physicochemical and structural differences between CNS and non-CNS drugs may assist both research areas. Because of the numerous and challenging issues in CNS drug discovery and the low success rates, pharmaceutical companies are beginning to deprioritize their drug discovery efforts in the CNS arena. Prompted by these challenges and to aid in the design of high-quality, efficacious CNS compounds, we analyzed the physicochemical property and the chemical structural profiles of 317 CNS and 626 non-CNS oral drugs. The conclusions derived provide an ideal property profile for lead selection and the property modification strategy during the lead optimization process. A list of substructural units that may be useful for CNS drug design was also provided here. A classification tree was also developed to differentiate between CNS drugs and non-CNS oral drugs. The combined analysis provided the following guidelines for designing high-quality CNS drugs: (i) topological molecular polar surface area of <76 Å(2) (25-60 Å(2)), (ii) at least one (one or two, including one aliphatic amine) nitrogen, (iii) fewer than seven (two to four) linear chains outside of rings, (iv) fewer than three (zero or one) polar hydrogen atoms, (v) volume of 740-970 Å(3), (vi) solvent accessible surface area of 460-580 Å(2), and (vii) positive QikProp parameter CNS. The ranges within parentheses may be used during lead optimization. One violation to this proposed profile may be acceptable. The

  6. Applications of Optimal Building Energy System Selection and Operation

    Energy Technology Data Exchange (ETDEWEB)

    Marnay, Chris; Stadler, Michael; Siddiqui, Afzal; DeForest, Nicholas; Donadee, Jon; Bhattacharya, Prajesh; Lai, Judy

    2011-04-01

    Berkeley Lab has been developing the Distributed Energy Resources Customer Adoption Model (DER-CAM) for several years. Given load curves for energy services requirements in a building microgrid (u grid), fuel costs and other economic inputs, and a menu of available technologies, DER-CAM finds the optimum equipment fleet and its optimum operating schedule using a mixed integer linear programming approach. This capability is being applied using a software as a service (SaaS) model. Optimisation problems are set up on a Berkeley Lab server and clients can execute their jobs as needed, typically daily. The evolution of this approach is demonstrated by description of three ongoing projects. The first is a public access web site focused on solar photovoltaic generation and battery viability at large commercial and industrial customer sites. The second is a building CO2 emissions reduction operations problem for a University of California, Davis student dining hall for which potential investments are also considered. And the third, is both a battery selection problem and a rolling operating schedule problem for a large County Jail. Together these examples show that optimization of building u grid design and operation can be effectively achieved using SaaS.

  7. High-Temperatures Rheometric Analysis Of Selected Heterogeneous Slag Systems

    Directory of Open Access Journals (Sweden)

    Migas P.

    2015-06-01

    Full Text Available It is known that the dynamic viscosity coefficient of slag – with an increased titanium compounds content in the reducing conditions of the blast furnace - may rapidly change. The products of the reduction reaction, precipitation and separation of titanium compounds are responsible for the thickening effect of the slag and the problems of permeability of blast furnace, causing anomalies in the dipping zone. The presence of solid components (particles in the melts determines the rheological character of the entire system. Identifying the rheological character of semi-solid slag systems provides opportunities for the development of mathematical modeling of liquid phase flows in a dripping zone of the blast furnace, allowing e.g to indentify the unstable parts of a metallurgical aggregate.

  8. IDENTIFYING NETWORK SYSTEMS IN POLAND – SELECTED ISSUES

    OpenAIRE

    Miszczak, Katarzyna

    2011-01-01

    The main aim of this article is attempt of defining and short characteristic of network systems in Poland. Contemporary mechanisms of social and economic development of space which determinants are technological progress, evolution of informative society and economy` s globalization make new operation` s conditions for territorial units. Spatial concentration follows related with benefits of creative cities and their peripheral areas but on the other hand connected with expansion of exchange`...

  9. BioEnergy transport systems. Life cycle assessment of selected bioenergy systems

    Energy Technology Data Exchange (ETDEWEB)

    Forsberg, Goeran

    1999-07-01

    Biomass for energy conversion is usually considered as a local resource. With appropriate logistic systems, access to biomass can be improved over a large geographical area. In this study, life cycle assessment (LCA) has been used as method to investigate the environmental impacts of selected bioenergy transport chains. As a case study, chains starting in Sweden and ending in Holland have been investigated. Biomass originates from tree sections or forest residues, the latter upgraded to bales or pellets. The study is concentrated on production of electricity, hot cooling water is considered as a loss. Electricity is, as the main case, produced from solid biomass in the importing country. Electricity can also be produced in the country of origin and exported via the trans-national grid as transportation media. As an alternative, a comparison is made with a coal cycle. The results show that contribution of emissions from long-range transportation is of minor importance. The use of fuels and electricity for operating machines and transportation carriers requires a net energy input in bioenergy systems which amounts to typically 7-9% of delivered electrical energy from the system. Emissions of key substances such as NO{sub x}, CO, S, hydrocarbons, and particles are low. Emissions of CO{sub 2} from biocombustion are considered to be zero since there is approximately no net contribution of carbon to the biosphere in an energy system based on biomass. A method to quantify non-renewability is presented. For coal, the non-renewability factor is calculated to be 110%. For most of the cases with bioenergy, the non-renewability factor is calculated to be between 6 and 11%. Reclamation of biomass results in certain losses of nutrients such as nitrogen, phosphorus and base cations such as K, Ca and Mg. These are balanced by weathering, vitalisation or ash recirculation procedures. Withdrawal of N from the ecological system is approximately 10 times the load from the technical

  10. Multinucleon transfer reactions for the sup 50 Ti+ sup 93 Nb system at sub- and near-barrier energies

    Energy Technology Data Exchange (ETDEWEB)

    Kim, H.J.; Gomez del Campo, J.; Shapira, D.; Stelson, P.H. (Oak Ridge National Lab., TN (USA)); Napoli, D.; Scarlassara, F. (Istituto Nazionale di Fisica Nucleare, Legnaro (Italy). Lab. Nazionale di Legnaro); D' Onofrio, A. (Istituto Nazionale di Fisica Nucleare, Naples (Italy)); Wieleczko, J.P. (Oak Ridge National Lab., TN (USA) CEA Centre d' Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette (France))

    1990-06-01

    A significant yield of multinucleon-transfer products is observed at back angles in quasielastic reactions between {sup 50}Ti and {sup 93}Nb at sub- and near-barrier energies. A variety of nuclidic species that require transfers of up to four nucleons are observed for E{sub c.m.} {ge} 103.9 MeV. The internuclear separation distance where the multinucleon-transfer products first emerge nearly coincides with the closest approach distance of the experimentally established fusion threshold energy, indicating a common origin for the fusion enhancement and multinucleon-transfer reactions.

  11. Local blood-brain barrier penetration following systemic contrast medium administration. A case report and an experimental study

    Energy Technology Data Exchange (ETDEWEB)

    Utz, R.; Ekholm, S.E.; Isaac, L.; Sands, M.; Fonte, D.

    The present study was initiated by a severe complication in a patient with renal dysfunction who developed cortical blindness and weakness of her left extremities 30 hours following renal and abdominal angiography. To evaluate the impact of prolonged high serum concentrations of contrast medium (CM) this clinical situation was simulated in a laboratory model using sheep with elevated serum levels of contrast medium maintained for 48 hours. The experimental data did not support the theory that the prolonged exposure to high circulating levels of contrast medium (4 ml/kg body weight of meglumine diatrizoate 60%) is sufficient alone to cause penetration of the blood-brain barrier.

  12. A New Selectable Marker System for Genetic Studies of Bacteria: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Parsons, D; Tolmasky, M; Chain, P; Segelke, B W

    2011-03-18

    Genetic manipulations in bacteria currently rely on the introduction of antibiotic resistance genes into a bacterial strain; for those organisms that will be used for commercial or industrial applications, the genetic cassette encoding the antibiotic resistance is sometimes removed after selection. it is clear that if alternative technologies could obviate the need to introduce antibiotic resistance into bacteria, they would most certainly become a standard tool in molecular micriobiology for commercial, industrial as well as research applications. Here, they present the development of a novel genetic engineering technology based on toxin-antitoxin systems to modify bacterial genomes without the use of antibiotic resistance in the mutagenesis process. The primary goal is to develop antibiotic-free selection for genetically altered select agent pathogens. They are adapting the toxinc-antitoxin system to enable gene replacement in select agent pathogens since the NIH restrictions introducing antibiotic resistance into select agent pathogens have hindered research with select agent pathogens.

  13. GROUP TRANSMIT ANTENNA SELECTION BASED ON GIS TECHNOLOGY FOR V-BLAST SYSTEM

    Institute of Scientific and Technical Information of China (English)

    Zhang Xiaoge; Xu Chengqi

    2008-01-01

    The conventional transmit antenna selection for Vertical Bell Laboratories Layered Space Time (V-BLAST) system is very complex because it needs to compute the inverse of channel matrices time after time. In this paper, a new group transmit antenna selection scheme for V-BLAST system is proposed. The 1st group transmit antennas are decided according to a certain selection criterion among the available antennas. Then, with Group Interference Suppression (GIS) technology, the interferences of the transmit symbols from the selected antennas can be suppressed. Finally, the 2nd group transmit antennas are decided among the residual available antennas. Simulations show that its performance is lower than that of the conventional selection scheme. However, the new selection scheme has lower complexity than the conventional one.

  14. Low Conductivity Thermal Barrier Coatings

    Science.gov (United States)

    Zhu, Dong-Ming

    2005-01-01

    Thermal barrier coatings will be more aggressively designed to protect gas turbine engine hot-section components in order to meet future engine higher fuel efficiency and lower emission goals. In this presentation, thermal barrier coating development considerations and requirements will be discussed. An experimental approach is established to monitor in real time the thermal conductivity of the coating systems subjected to high-heat-flux, steady-state and cyclic temperature gradients. Advanced low conductivity thermal barrier coatings have also been developed using a multi-component defect clustering approach, and shown to have improved thermal stability. The durability and erosion resistance of low conductivity thermal barrier coatings have been improved utilizing advanced coating architecture design, composition optimization, in conjunction with more sophisticated modeling and design tools.

  15. Selectable linear or quadratic coupling in an optomechanical system

    CERN Document Server

    Xuereb, André

    2012-01-01

    There has been much interest recently in the analysis of optomechanical systems incorporating dielectric nano- or microspheres inside a cavity field. We analyse here the situation when one of the mirrors of the cavity itself is also allowed to move. We reveal that the interplay between the two oscillators yields a cross-coupling that results in, e.g., appreciable cooling and squeezing of the motion of the sphere, despite its nominal quadratic coupling. We also discuss a simple modification that would allow this cross-coupling to be removed at will, thereby yielding a purely quadratic coupling for the sphere.

  16. Multi-spectral band selection for satellite-based systems

    Energy Technology Data Exchange (ETDEWEB)

    Clodius, W.B.; Weber, P.G.; Borel, C.C.; Smith, B.W.

    1998-09-01

    The design of satellite based multispectral imaging systems requires the consideration of a number of tradeoffs between cost and performance. The authors have recently been involved in the design and evaluation of a satellite based multispectral sensor operating from the visible through the long wavelength IR. The criteria that led to some of the proposed designs and the modeling used to evaluate and fine tune the designs will both be discussed. These criteria emphasized the use of bands for surface temperature retrieval and the correction of atmospheric effects. The impact of cost estimate changes on the final design will also be discussed.

  17. Species selection in a reactor-settler system.

    Science.gov (United States)

    Sheintuch, M

    1987-10-05

    The competition between flocculating and nonflocculating microorganisms was investigated in a continuous reactor-settler system (e.g. activated sludge). Co existence states were found to be possible, over a certain domain of operating conditions, even with simple monotonic kinetics and simple competition. Multiple solutions exist when coexistence states are unstable. Coexistence solutions are stable when the flocculating bacteria grow faster at feed conditions as in the activated sludge problem. The analysis applies to one or several mixed or plug flow reactors. Other effects, such as enrichment of the recycle stream by the flocculating microorganism or substrate adsorption and storage, may change the structure of solution.

  18. Desiccation-Induced Volumetric Shrinkage of Compacted Metakaolin-Treated Black Cotton Soil for a Hydraulic Barriers System

    Directory of Open Access Journals (Sweden)

    Moses George

    2016-03-01

    Full Text Available Black cotton soil treated with up to 24% metakaolin (MCL content was prepared by molding water contents of −2, 0, 2, 4 and 6% of optimum moisture content (OMC and compacted with British Standard Light (BSL and West African Standard (WAS or ‘Intermediate’ energies. The specimens were extruded from the compaction molds and allowed to air dry in a laboratory in order to assess the effect of desiccation-induced shrinkage on the compacted mix for use as a hydraulic barrier in a waste containment application. The results recorded show that the volumetric shrinkage strain (VSS values were large within the first 10 days of drying; the VSS values increased with a higher molding of the water content, relative to the OMC. The VSS generally increased with a higher initial degree of saturation for the two compactive efforts, irrespective of the level of MCL treatment. Generally, the VSS decreased with an increasing MCL content. Only specimens treated with a minimum 20% MCL content and compacted with the WAS energy satisfied the regulatory maximum VSS of 4% for use as a hydraulic barrier.

  19. Desiccation-Induced Volumetric Shrinkage of Compacted Metakaolin-Treated Black Cotton Soil for a Hydraulic Barriers System

    Science.gov (United States)

    Moses, George; Peter, Oriola F. O.; Osinubi, Kolawole J.

    2016-03-01

    Black cotton soil treated with up to 24% metakaolin (MCL) content was prepared by molding water contents of -2, 0, 2, 4 and 6% of optimum moisture content (OMC) and compacted with British Standard Light (BSL) and West African Standard (WAS) or `Intermediate' energies. The specimens were extruded from the compaction molds and allowed to air dry in a laboratory in order to assess the effect of desiccation-induced shrinkage on the compacted mix for use as a hydraulic barrier in a waste containment application. The results recorded show that the volumetric shrinkage strain (VSS) values were large within the first 10 days of drying; the VSS values increased with a higher molding of the water content, relative to the OMC. The VSS generally increased with a higher initial degree of saturation for the two compactive efforts, irrespective of the level of MCL treatment. Generally, the VSS decreased with an increasing MCL content. Only specimens treated with a minimum 20% MCL content and compacted with the WAS energy satisfied the regulatory maximum VSS of 4% for use as a hydraulic barrier.

  20. Effect of immune system stimulation and divergent selection for residual feed intake on digestive capacity of the small intestine in growing pigs.

    Science.gov (United States)

    Rakhshandeh, A; Dekkers, J C M; Kerr, B J; Weber, T E; English, J; Gabler, N K

    2012-12-01

    Little is known of the consequences of divergent selection for residual feed intake (RFI) on intestinal digestion capacity, particularly during immune system stimulation (ISS). Our objective was to evaluate the impact of ISS and divergent selection for RFI on apparent ileal digestibility (AID) and apparent fecal digestibility (AFD) of nutrients and intestinal nutrient active transport and barrier function. Twenty-eight gilts (63 ± 4 kg BW) from low RFI (LRFI; n = 14) and high RFI (HRFI; n = 14) Yorkshire lines were randomly selected from the Iowa State University RFI herd. Following adaptation, 8 pigs in each line were injected intramuscularly and every 48 h for 7 d with increasing amounts of Escherichia coli lipopolysaccharide (ISS+). Remaining pigs were injected with saline (ISS-). Pigs were then euthanized and ileal digesta was collected for measuring AID of nutrients. Fecal samples were collected on a daily basis and pooled for measuring AFD of nutrients. A segment of ileum was used to measure nutrient transport and transepithelial resistance (TER) and/or barrier integrity by Ussing chambers. No effects of line or its interaction with ISS on AID of CP (N × 6.25) and OM, TER, and active nutrients transport were observed. However, ISS decreased (P < 0.05) and tended to (P < 0.1) decrease AID of CP and OM, respectively. Decrease in AFD of CP as result of ISS was greater in the LRFI line compared to the HRFI line (P < 0.05). Relative to ISS-, active glucose and P transport was greater in ISS+ pigs (P < 0.05). Genetic selection for LRFI increases the AFD but has no effect on AID of nutrients. It also reduces the total tract digestive capacity of growing pigs during ISS. Immune system stimulation affects both AID and AFD of dietary CP.

  1. Neuromorphic VLSI Models of Selective Attention: From Single Chip Vision Sensors to Multi-chip Systems

    Directory of Open Access Journals (Sweden)

    Giacomo Indiveri

    2008-09-01

    Full Text Available Biological organisms perform complex selective attention operations continuously and effortlessly. These operations allow them to quickly determine the motor actions to take in response to combinations of external stimuli and internal states, and to pay attention to subsets of sensory inputs suppressing non salient ones. Selective attention strategies are extremely effective in both natural and artificial systems which have to cope with large amounts of input data and have limited computational resources. One of the main computational primitives used to perform these selection operations is the Winner-Take-All (WTA network. These types of networks are formed by arrays of coupled computational nodes that selectively amplify the strongest input signals, and suppress the weaker ones. Neuromorphic circuits are an optimal medium for constructing WTA networks and for implementing efficient hardware models of selective attention systems. In this paper we present an overview of selective attention systems based on neuromorphic WTA circuits ranging from single-chip vision sensors for selecting and tracking the position of salient features, to multi-chip systems implement saliency-map based models of selective attention.

  2. 21 CFR 866.6020 - Immunomagnetic circulating cancer cell selection and enumeration system.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Immunomagnetic circulating cancer cell selection..., DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY DEVICES Tumor Associated Antigen immunological Test Systems § 866.6020 Immunomagnetic circulating cancer cell selection...

  3. PROJECT W-551 INTERIM PRETREATMENT SYSTEM TECHNOLOGY SELECTION SUMMARY DECISION REPORT AND RECOMMENDATION

    Energy Technology Data Exchange (ETDEWEB)

    CONRAD EA

    2008-08-12

    This report provides the conclusions of the tank farm interim pretreatment technology decision process. It documents the methodology, data, and results of the selection of cross-flow filtration and ion exchange technologies for implementation in project W-551, Interim Pretreatment System. This selection resulted from the evaluation of specific scope criteria using quantitative and qualitative analyses, group workshops, and technical expert personnel.

  4. Non-Precious Bimetallic Catalysts for Selective Dehydrogenation of an Organic Chemical Hydride System

    KAUST Repository

    Shaikh Ali, Anaam

    2015-07-06

    Methylcyclohexane (MCH)-Toluene (TOL) chemical hydride cycles as a hydrogen carrier system is successful with the selective dehydrogenation reaction of MCH to TOL, which has been achieved only using precious Pt-based catalysts. Herein, we report improved selectivity using non-precious metal nickel-based bimetallic catalysts, where the second metal occupies the unselective step sites.

  5. Facilitators and Barriers to Safe Medication Administration to Hospital Inpatients: A Mixed Methods Study of Nurses' Medication Administration Processes and Systems (the MAPS Study.

    Directory of Open Access Journals (Sweden)

    Monsey McLeod

    Full Text Available Research has documented the problem of medication administration errors and their causes. However, little is known about how nurses administer medications safely or how existing systems facilitate or hinder medication administration; this represents a missed opportunity for implementation of practical, effective, and low-cost strategies to increase safety.To identify system factors that facilitate and/or hinder successful medication administration focused on three inter-related areas: nurse practices and workarounds, workflow, and interruptions and distractions.We used a mixed-methods ethnographic approach involving observational fieldwork, field notes, participant narratives, photographs, and spaghetti diagrams to identify system factors that facilitate and/or hinder successful medication administration in three inpatient wards, each from a different English NHS trust. We supplemented this with quantitative data on interruptions and distractions among other established medication safety measures.Overall, 43 nurses on 56 drug rounds were observed. We identified a median of 5.5 interruptions and 9.6 distractions per hour. We identified three interlinked themes that facilitated successful medication administration in some situations but which also acted as barriers in others: (1 system configurations and features, (2 behaviour types among nurses, and (3 patient interactions. Some system configurations and features acted as a physical constraint for parts of the drug round, however some system effects were partly dependent on nurses' inherent behaviour; we grouped these behaviours into 'task focused', and 'patient-interaction focused'. The former contributed to a more streamlined workflow with fewer interruptions while the latter seemed to empower patients to act as a defence barrier against medication errors by being: (1 an active resource of information, (2 a passive information resource, and/or (3 a 'double-checker'.We have identified practical

  6. Health system barriers to access and use of magnesium sulfate for women with severe pre-eclampsia and eclampsia in Pakistan: evidence for policy and practice.

    Science.gov (United States)

    Bigdeli, Maryam; Zafar, Shamsa; Assad, Hafeez; Ghaffar, Adbul

    2013-01-01

    Severe pre-eclampsia and eclampsia are rare but serious complications of pregnancy that threaten the lives of mothers during childbirth. Evidence supports the use of magnesium sulfate (MgSO4) as the first line treatment option for severe pre-eclampsia and eclampsia. Eclampsia is the third major cause of maternal mortality in Pakistan. As in many other Low- and Middle-Income Countries (LMIC), it is suspected that MgSO4 is critically under-utilized in the country. There is however a lack of information on context-specific health system barriers that prevent optimal use of this life-saving medicine in Pakistan. Combining quantitative and qualitative methods, namely policy document review, key informant interviews, focus group discussions and direct observation at health facility, we explored context-specific health system barriers and enablers that affect access and use of MgSO4 for severe pre-eclampsia and eclampsia in Pakistan. Our study finds that while international recommendations on MgSO4 have been adequately translated in national policies in Pakistan, the gap remains in implementation of national policies into practice. Barriers to access to and effective use of MgSO4 occur at health facility level where the medicine was not available and health staff was reluctant to use it. Low price of the medicine and the small market related to its narrow indications acted as disincentives for effective marketing. Results of our survey were further discussed in a multi-stakeholder round-table meeting and an action plan for increasing access to this life-saving medicine was identified.

  7. Health system barriers to access and use of magnesium sulfate for women with severe pre-eclampsia and eclampsia in Pakistan: evidence for policy and practice.

    Directory of Open Access Journals (Sweden)

    Maryam Bigdeli

    Full Text Available Severe pre-eclampsia and eclampsia are rare but serious complications of pregnancy that threaten the lives of mothers during childbirth. Evidence supports the use of magnesium sulfate (MgSO4 as the first line treatment option for severe pre-eclampsia and eclampsia. Eclampsia is the third major cause of maternal mortality in Pakistan. As in many other Low- and Middle-Income Countries (LMIC, it is suspected that MgSO4 is critically under-utilized in the country. There is however a lack of information on context-specific health system barriers that prevent optimal use of this life-saving medicine in Pakistan. Combining quantitative and qualitative methods, namely policy document review, key informant interviews, focus group discussions and direct observation at health facility, we explored context-specific health system barriers and enablers that affect access and use of MgSO4 for severe pre-eclampsia and eclampsia in Pakistan. Our study finds that while international recommendations on MgSO4 have been adequately translated in national policies in Pakistan, the gap remains in implementation of national policies into practice. Barriers to access to and effective use of MgSO4 occur at health facility level where the medicine was not available and health staff was reluctant to use it. Low price of the medicine and the small market related to its narrow indications acted as disincentives for effective marketing. Results of our survey were further discussed in a multi-stakeholder round-table meeting and an action plan for increasing access to this life-saving medicine was identified.

  8. Advanced turbine systems program conceptual design and product development. Task 3 -- System selection; Topical report

    Energy Technology Data Exchange (ETDEWEB)

    White, D.J.

    1994-07-01

    Solar Turbines Incorporated has elected to pursue an intercooled and recuperated (ICR) gas turbine system to exceed the goals of the DOE Advanced Turbine Systems (ATS) program, which are to develop and commercialize an industrial gas turbine system that operates at thermal efficiencies at least 15% higher than 1991 products, and with emissions not exceeding eight ppmv NOx and 20 ppmv CO and UHC. Solar`s goal is to develop a commercially viable industrial system (3--20 MW) driven by a gas turbine engine with a thermal efficiency of 50% (ATS50), with the flexibility to meet the differing operational requirements of various markets. Dispersed power generation is currently considered to be the primary future target market for the ICR in the 5--15 MW size class. The ICR integrated system approach provides an ideal candidate for the assumed dispersed power market, with its small footprint, easy transportability, and environmental friendliness. In comparison with other systems that use water or toxic chemicals such as ammonia for NOx control, the ICR has no consumables other than fuel and air. The low pressure ratio of the gas turbine engine also is favorable in that less parasitic power is needed to pump the natural gas into the combustor than for simple-cycle machines. Solar has narrowed the ICR configuration to two basic approaches, a 1-spool, and a 2-spool version of the ATS50. The 1-spool engine will have a lower first-cost but lower part-power efficiencies. The 2-spool ATS may not only have better part-power efficiency, its efficiency will also be less sensitive to reduced turbine rotor inlet temperature levels. Thus hot-end parts life can be increased with only small sacrifices in efficiency. The flexibility of the 2-spool arrangement in meeting customer needs is its major advantage over the 1-spool. This Task 3 Topical Report is intended to present Solar`s preliminary system selection based upon the initial trade-off studies performed to date.

  9. A Multidisciplinary Research Team Approach to Computer-Aided Drafting (CAD) System Selection. Final Report.

    Science.gov (United States)

    Franken, Ken; And Others

    A multidisciplinary research team was assembled to review existing computer-aided drafting (CAD) systems for the purpose of enabling staff in the Design Drafting Department at Linn Technical College (Missouri) to select the best system out of the many CAD systems in existence. During the initial stage of the evaluation project, researchers…

  10. Metal selectivity by the virulence-associated yersiniabactin metallophore system

    Science.gov (United States)

    Koh, Eun-Ik; Hung, Chia S.; Parker, Kaveri S.; Crowley, Jan R.; Giblin, Daryl E.; Henderson, Jeffrey P.

    2016-01-01

    SUMMARY Uropathogenic Escherichia coli secrete siderophores during human infections. Although siderophores are classically defined by their ability to bind ferric ions, the virulence-associated siderophore yersiniabactin was recently found to bind divalent copper ions during urinary tract infections. Here we use a mass spectrometric approach to determine the extent of non-ferric metal interactions by yersiniabactin and its TonB-dependent outer membrane importer FyuA. In addition to copper, iron and gallium ions, yersiniabactin was also observed to form stable nickel, cobalt, and chromium ion complexes. In E. coli, copper(II) and all other non-ferric yersiniabactin complexes were imported by FyuA in a TonB-dependent manner. Among metal-yersiniabactin complexes, copper(II) yersiniabactin is predicted to be structurally distinctive and was the only complex not to competitively inhibit ferric yersiniabactin import. These results are consistent with yersiniabactin as part of a metallophore system able to prioritize ferric complex uptake in high copper environments. PMID:25824627

  11. Using the AHP Method to Select an ERP System for an SME Manufacturing Company

    Directory of Open Access Journals (Sweden)

    Kłos Sławomir

    2014-09-01

    Full Text Available This paper proposes the application of the Analytic Hierarchy Process method to support decision making regarding the selection of an Enterprise Resource Planning system in a manufacturing company. The main assumption of the work is that the management of the selection of an ERP system should consider that the most important selection criteria are concerned with the functionality of the ERP system. Besides this, the aspects of total cost of ownership, technical support and implementation time or vendor experience are taken into consideration to guarantee a successful ERP implementation. The proposed procedure of an ERP system selection is dedicated for small and medium manufacturing enterprises. A structure of attributes for the AHP method is proposed on the basis of an analysis and identification of critical success factors. Different kinds of production (make-to-stock, make-to-order and engineer-to-order are taken into consideration. Illustrative examples are also given.

  12. Random Gaussian process effect upon selective system of spectra heterodyne analyzer

    Directory of Open Access Journals (Sweden)

    N. F. Vollerner

    1967-12-01

    Full Text Available The formula is obtained that describe mean power changing the selective system output by changing speed tuning of the spectra heterodyne analyzer when searching random stationary processes.

  13. A Dynamic Supramolecular System Exhibiting Substrate Selectivity in the Catalytic Epoxidation of Olefins

    DEFF Research Database (Denmark)

    Jonsson, Stefan; Odille, Fabrice G. J.; Norrby, Per-Ola;

    2005-01-01

    A dynamic supramolecular system involving hydrogen bonding between a Mn(III) salen catalyst and a Zn(II) porphyrin receptor exhibits selectivity for pyridine appended cis-beta-substituted styrene derivatives over phenyl appended derivatives in a catalytic epoxidation reaction.......A dynamic supramolecular system involving hydrogen bonding between a Mn(III) salen catalyst and a Zn(II) porphyrin receptor exhibits selectivity for pyridine appended cis-beta-substituted styrene derivatives over phenyl appended derivatives in a catalytic epoxidation reaction....

  14. Selecting a Web Content Management System for an Academic Library Website

    Directory of Open Access Journals (Sweden)

    Elizabeth L. Black

    2011-12-01

    Full Text Available This article describes the selection of a web content management system (CMS at the Ohio State University Libraries. The author outlines the need for a CMS, describes the system requirements to support a large distributed content model and shares the CMS trial method used, which directly included content provider feedback side-by-side with the technical experts. The selected CMS is briefly described.

  15. Multi-Barrier Protection of Drinking Water Systems in Ontario: A Comparison of First Nation and Non-First Nation Communities

    Directory of Open Access Journals (Sweden)

    Budhendra Singh

    2012-11-01

    Full Text Available In some way or another, all levels of government in Canada and First Nations share responsibility to implement multi-barrier protection of drinking water. The goal is to protect water from source to tap to minimize risk so that people have access to adequate and safe drinking water. The federal government has committed to assist First Nations achieve comparable levels of service standards available to non-First Nation communities. However, several recent reports on the status of drinking water services standards in First Nations indicate that people in these communities often experience greater health risks than those living off reserves. Using the federal drinking water risk evaluation guidelines, the capacities of First Nations and non-First Nations in Ontario to implement multi-barrier protection of their drinking water systems are compared. The Risk Level Evaluation Guidelines for Water and Wastewater Treatment in First Nation Communities rank drinking water systems as low, medium, or high risk based on information about source water, system design, system operation, reporting, and operator expertise. The risk evaluation scores for First Nations drinking water systems were obtained from Aboriginal Affairs and Northern Development Canada. A survey based on the federal Risk Level Evaluation Guidelines was sent to non-First Nation communities throughout Ontario with 54 communities responding. The capacity among First Nations was variable throughout the province, whereas all of the municipalities were in the low risk category, even small and northern non-First Nation community water systems. It is clear that the financial and technological capacity issues should be addressed regardless of the legislative and regulatory regime that is established. The current governance and management structure does not appear to be significantly reducing the gap in service standards despite financial investment. Exploring social or other underlying determinants

  16. Drug Delivery Through the Skin: Molecular Simulations of Barrier Lipids to Design more Effective Noninvasive Dermal and Transdermal Delivery Systems for Small Molecules Biologics and Cosmetics

    Energy Technology Data Exchange (ETDEWEB)

    J Torin Huzil; S Sivaloganathan; M Kohandel; M Foldvari

    2011-12-31

    The delivery of drugs through the skin provides a convenient route of administration that is often preferable to injection because it is noninvasive and can typically be self-administered. These two factors alone result in a significant reduction of medical complications and improvement in patient compliance. Unfortunately, a significant obstacle to dermal and transdermal drug delivery alike is the resilient barrier that the epidermal layers of the skin, primarily the stratum corneum, presents for the diffusion of exogenous chemical agents. Further advancement of transdermal drug delivery requires the development of novel delivery systems that are suitable for modern, macromolecular protein and nucleotide therapeutic agents. Significant effort has already been devoted to obtain a functional understanding of the physical barrier properties imparted by the epidermis, specifically the membrane structures of the stratum corneum. However, structural observations of membrane systems are often hindered by low resolutions, making it difficult to resolve the molecular mechanisms related to interactions between lipids found within the stratum corneum. Several models describing the molecular diffusion of drug molecules through the stratum corneum have now been postulated, where chemical permeation enhancers are thought to disrupt the underlying lipid structure, resulting in enhanced permeability. Recent investigations using biphasic vesicles also suggested a possibility for novel mechanisms involving the formation of complex polymorphic lipid phases. In this review, we discuss the advantages and limitations of permeation-enhancing strategies and how computational simulations, at the atomic scale, coupled with physical observations can provide insight into the mechanisms of diffusion through the stratum corneum.

  17. Planet formation in stellar binaries II: overcoming the fragmentation barrier in alpha Centauri and gamma Cephei-like systems

    CERN Document Server

    Rafikov, Roman R

    2014-01-01

    Planet formation in small-separation (~20 AU) eccentric binaries such as gamma Cephei or alpha Centauri is believed to be adversely affected by the presence of the stellar companion. Strong dynamical excitation of planetesimals by the eccentric companion can result in collisional destruction (rather than growth) of 1-100 km objects, giving rise to the "fragmentation barrier" for planet formation. We revise this issue using a novel description of secular dynamics of planetesimals in binaries, which accounts for the gravity of the eccentric, coplanar protoplanetary disk, as well as gas drag. By studying planetesimal collision outcomes we show, in contrast to many previous studies, that planetesimal growth and subsequent formation of planets (including gas giants) in AU-scale orbits within ~20 AU separation binaries may be possible, provided that the protoplanetary disks are massive (>10^{-2}M_\\odot) and only weakly eccentric (disk eccentricity <0.01). These requirements are compatible with both the existence...

  18. Social barriers to pathogen transmission in wild animal populations

    Energy Technology Data Exchange (ETDEWEB)

    Loehle, C.

    1995-03-01

    Diseases and pathogens are receiving increasing recognition as sources of mortality in animal populations. Immune system strength is clearly important in fending off pathogen attack. Physical barriers to pathogen entry are also important. Various individual behaviors are efficacious in reducing contact with diseases and pests. This paper focuses on a fourth mode of defense: social barriers to transmission. Various social behaviors have pathogen transmission consequences. Selective pressures on these social behaviors may therefore exist. Effects on pathogen transmission of mating strategies, social avoidance, group size, group isolation, and other behaviors are explored. It is concluded that many of these behaviors may have been affected by selection pressures to reduce transmission of pathogens. 84 refs., 1 tab.

  19. Study on MAX-MIN Ant System with Random Selection in Quadratic Assignment Problem

    Science.gov (United States)

    Iimura, Ichiro; Yoshida, Kenji; Ishibashi, Ken; Nakayama, Shigeru

    Ant Colony Optimization (ACO), which is a type of swarm intelligence inspired by ants' foraging behavior, has been studied extensively and its effectiveness has been shown by many researchers. The previous studies have reported that MAX-MIN Ant System (MMAS) is one of effective ACO algorithms. The MMAS maintains the balance of intensification and diversification concerning pheromone by limiting the quantity of pheromone to the range of minimum and maximum values. In this paper, we propose MAX-MIN Ant System with Random Selection (MMASRS) for improving the search performance even further. The MMASRS is a new ACO algorithm that is MMAS into which random selection was newly introduced. The random selection is one of the edgechoosing methods by agents (ants). In our experimental evaluation using ten quadratic assignment problems, we have proved that the proposed MMASRS with the random selection is superior to the conventional MMAS without the random selection in the viewpoint of the search performance.

  20. Low complexity antenna selection for V-BLAST systems with OSIC detection

    Directory of Open Access Journals (Sweden)

    Bae Youngtaek

    2011-01-01

    Full Text Available Abstract Multiple-input multiple-output (MIMO systems have an advantage of spectral efficiency compared to single-input single-output systems, which means that the MIMO systems have significantly higher data throughput. The V-BLAST (Vertical Bell Laboratories Layered Space Time scheme is a popular transceiver structure which has relatively good performance. In the V-BLAST scheme, ordered successive interference cancellation (OSIC technique was proposed as a possible efficient detection method in terms of performance and complexity. However, MIMO systems suffer from high complexity and implementation cost. As a practical solution, a technique called antenna selection has been introduced. Since the existing literature considered only the capacity-based selection, we develop an optimal selection method for V-BLAST scheme using OSIC detection with respect to error rate performance in this article. Its complexity is shown to be proportional to the fourth power of the number of transmit antennas. To reduce the complexity without significant performance degradation compared to the optimal selection method, a near-optimal selection method is also proposed. Simulation results show that the proposed selection method is very close to the performance of optimal selection.

  1. Pattern Recognition Methods and Features Selection for Speech Emotion Recognition System

    Science.gov (United States)

    Partila, Pavol; Voznak, Miroslav; Tovarek, Jaromir

    2015-01-01

    The impact of the classification method and features selection for the speech emotion recognition accuracy is discussed in this paper. Selecting the correct parameters in combination with the classifier is an important part of reducing the complexity of system computing. This step is necessary especially for systems that will be deployed in real-time applications. The reason for the development and improvement of speech emotion recognition systems is wide usability in nowadays automatic voice controlled systems. Berlin database of emotional recordings was used in this experiment. Classification accuracy of artificial neural networks, k-nearest neighbours, and Gaussian mixture model is measured considering the selection of prosodic, spectral, and voice quality features. The purpose was to find an optimal combination of methods and group of features for stress detection in human speech. The research contribution lies in the design of the speech emotion recognition system due to its accuracy and efficiency. PMID:26346654

  2. Pattern Recognition Methods and Features Selection for Speech Emotion Recognition System

    Directory of Open Access Journals (Sweden)

    Pavol Partila

    2015-01-01

    Full Text Available The impact of the classification method and features selection for the speech emotion recognition accuracy is discussed in this paper. Selecting the correct parameters in combination with the classifier is an important part of reducing the complexity of system computing. This step is necessary especially for systems that will be deployed in real-time applications. The reason for the development and improvement of speech emotion recognition systems is wide usability in nowadays automatic voice controlled systems. Berlin database of emotional recordings was used in this experiment. Classification accuracy of artificial neural networks, k-nearest neighbours, and Gaussian mixture model is measured considering the selection of prosodic, spectral, and voice quality features. The purpose was to find an optimal combination of methods and group of features for stress detection in human speech. The research contribution lies in the design of the speech emotion recognition system due to its accuracy and efficiency.

  3. System and method for programmable bank selection for banked memory subsystems

    Energy Technology Data Exchange (ETDEWEB)

    Blumrich, Matthias A. (Ridgefield, CT); Chen, Dong (Croton on Hudson, NY); Gara, Alan G. (Mount Kisco, NY); Giampapa, Mark E. (Irvington, NY); Hoenicke, Dirk (Seebruck-Seeon, DE); Ohmacht, Martin (Yorktown Heights, NY); Salapura, Valentina (Chappaqua, NY); Sugavanam, Krishnan (Mahopac, NY)

    2010-09-07

    A programmable memory system and method for enabling one or more processor devices access to shared memory in a computing environment, the shared memory including one or more memory storage structures having addressable locations for storing data. The system comprises: one or more first logic devices associated with a respective one or more processor devices, each first logic device for receiving physical memory address signals and programmable for generating a respective memory storage structure select signal upon receipt of pre-determined address bit values at selected physical memory address bit locations; and, a second logic device responsive to each of the respective select signal for generating an address signal used for selecting a memory storage structure for processor access. The system thus enables each processor device of a computing environment memory storage access distributed across the one or more memory storage structures.

  4. Selection of natural Gas Fired Advanced Turbine Systems (GFATS) program - Task 3. Topical report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-06-01

    Research continued on natural gas-fired turbines.The objective of Task 3 was to perform initial trade studies and select one engine system (Gas-Fired Advanced Turbine System [GFATS]) that the contractor could demonstrate, at full scale, in the 1998 to 2000 time frame. This report describes the results of the selection process. This task, including Allison internal management reviews of the selected system, has been completed. Allison`s approach to ATS is to offer an engine family that is based on the newest T406 high technology engine. This selection was based on a number of parameters including return on investment (ROI), internal rate of return (IRR) market size and potential sales into that market. This base engine family continues a history at Allison of converting flight engine products to industrial use.

  5. Hydrogen selective membrane for the natural gas system. Development of CO{sub 2}-selective biogas membrane. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Vestboe, A.P.

    2012-02-15

    The project started as a literature study and technology development project for a hydrogen selective membrane for the natural gas system. The introduction of hydrogen (for example produced from wind turbines by surplus electricity) in the gas system makes it possible to store energy which can be selectively used with high energy conversion in fuel cells directly located at the end users. In order to make this possible, it is necessary to have a separating unit that can selectively remove hydrogen from the gas mixture and deliver it as fuel to the electrical generator (a fuel cell). In the project, several existing technologies were evaluated with regard to the application in view. It was concluded that while other technologies are ripe, they are costly in energy and unsuitable for the relatively low capacity application that are in question close to the end users. Membrane technology was evaluated to be the most suitable, although the technology is still under development in many cases. In the project it was found that metallic membranes in the form of palladium coated stainless discs would answer the needs for the high purity needed. Laboratory development yielded discs that could separate hydrogen from natural gas, however, the flux was low compared to the needs of the application. It was found that at least 2 bar pressure difference of hydrogen would be needed to get a high enough flux. The way to achieve this pressure would necessitate a compressor which would consume an energy amount high enough to invalidate the concept. When concluding on the results and the study it was found that the direction of the project could be changed towards developing CO{sub 2}-selective membranes with the goal of developing membrane technology that could upgrade biogas by removing CO{sub 2}. The laboratory equipment and setup that were developed in the first part of the project could be used directly in this second part of the project. In this second part of the project it was

  6. Hydrogen selective membrane for the natural gas system. Development of CO{sub 2}-selective biogas membrane. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Vestboe, A.P.

    2012-02-15

    The project started as a literature study and technology development project for a hydrogen selective membrane for the natural gas system. The introduction of hydrogen (for example produced from wind turbines by surplus electricity) in the gas system makes it possible to store energy which can be selectively used with high energy conversion in fuel cells directly located at the end users. In order to make this possible, it is necessary to have a separating unit that can selectively remove hydrogen from the gas mixture and deliver it as fuel to the electrical generator (a fuel cell). In the project, several existing technologies were evaluated with regard to the application in view. It was concluded that while other technologies are ripe, they are costly in energy and unsuitable for the relatively low capacity application that are in question close to the end users. Membrane technology was evaluated to be the most suitable, although the technology is still under development in many cases. In the project it was found that metallic membranes in the form of palladium coated stainless discs would answer the needs for the high purity needed. Laboratory development yielded discs that could separate hydrogen from natural gas, however, the flux was low compared to the needs of the application. It was found that at least 2 bar pressure difference of hydrogen would be needed to get a high enough flux. The way to achieve this pressure would necessitate a compressor which would consume an energy amount high enough to invalidate the concept. When concluding on the results and the study it was found that the direction of the project could be changed towards developing CO{sub 2}-selective membranes with the goal of developing membrane technology that could upgrade biogas by removing CO{sub 2}. The laboratory equipment and setup that were developed in the first part of the project could be used directly in this second part of the project. In this second part of the project it was

  7. Selection of the optimal model of integrated sustainable management system in the mining companies

    OpenAIRE

    Miletić, Slavica; Bogdanović, Dejan; Paunković, Jane

    2015-01-01

    The multi-criteria analysis for the selection of the optimal model of integrated management system was conducted in this paper in order to improve the performance of mining companies. Integrated management system is the process of integrating of different management systems in a contemporary business as a requirement for each company in order to survive in the market. Modern companies that have implemented integrated management system work better, have arranged processes, improve its structur...

  8. Creep, Fatigue and Fracture Behavior of Environmental Barrier Coating and SiC-SiC Ceramic Matrix Composite Systems: The Role of Environment Effects

    Science.gov (United States)

    Zhu, Dongming; Ghosn, Louis J.

    2015-01-01

    Advanced environmental barrier coating (EBC) systems for low emission SiCSiC CMC combustors and turbine airfoils have been developed to meet next generation engine emission and performance goals. This presentation will highlight the developments of NASAs current EBC system technologies for SiC-SiC ceramic matrix composite combustors and turbine airfoils, their performance evaluation and modeling progress towards improving the engine SiCSiC component temperature capability and long-term durability. Our emphasis has also been placed on the fundamental aspects of the EBC-CMC creep and fatigue behaviors, and their interactions with turbine engine oxidizing and moisture environments. The EBC-CMC environmental degradation and failure modes, under various simulated engine testing environments, in particular involving high heat flux, high pressure, high velocity combustion conditions, will be discussed aiming at quantifying the protective coating functions, performance and durability, and in conjunction with damage mechanics and fracture mechanics approaches.

  9. [Dmt(1)]DALDA is highly selective and potent at mu opioid receptors, but is not cross-tolerant with systemic morphine.

    Science.gov (United States)

    Riba, Pal; Ben, Yong; Nguyen, Thi M-D; Furst, Susanna; Schiller, Peter W; Lee, Nancy M

    2002-01-01

    The clinical effectiveness of morphine is limited by several side effects, including the development of tolerance and dependence. Most of these side effects are believed to be mediated by central opioid receptors; therefore, hydrophilic opioids, which don't cross the blood-brain barrier, may have advantages over morphine in some clinical applications. We recently synthesized several analogues of DALDA (Tyr-D-Arg-Phe-Lys-NH2), a highly hydrophilic peptide derived from the endogenous opioid peptide dermorphin; all of them, particularly [Dmt(1)] DALDA (Dmt - 2',6'-dimethyl tyrosine), had high potency and selectivity at mu receptors, the target of morphine, in activity assays. Here we report the pharmacological characterization of [Dmt(1)] DALDA in the whole animal. [Dmt(1)]DALDA was 40 times more potent than morphine in inducing antinociception in mice when both drugs were given s.c., and 6-14 times more potent than DAMGO, a selective m agonist, when both drugs were given it. However, [Dmt(1)]DALDA showed poor cross-tolerance to morphine; thus chronic morphine treatment of animals increased the antinociceptive AD(50) of systemic [Dmt(1)]DALDA two fold or less, as compared to an 8-9-fold increase for morphine and a 4-5-fold increase for DAMGO. The antinociceptive activity of [Dmt(1)]DALDA (i.t) was blocked by CTAP, a selective mu antagonist, but not by TIPP psi, a selective delta antagonist, nor by nor-BNI, a selective kappa antagonist. [Dmt(1)]DALDA-induced antinociception was also blocked by naloxone methiodide, an antagonist that does not cross the blood-brain barrier, when agonist and antagonist were given i.t. or i.c.v., but not when they were given s.c. We conclude that [Dmt(1)] DALDA is a highly potent analgesic acting at mu receptors. Though it appears to penetrate the blood-brain barrier, it exhibits low cross-tolerance to morphine, suggesting that it may have advantages over the latter in certain clinical applications.

  10. Blood-brain barrier permeability imaging using perfusion computed tomography

    Directory of Open Access Journals (Sweden)

    Avsenik Jernej

    2015-06-01

    Full Text Available Background. The blood-brain barrier represents the selective diffusion barrier at the level of the cerebral microvascular endothelium. Other functions of blood-brain barrier include transport, signaling and osmoregulation. Endothelial cells interact with surrounding astrocytes, pericytes and neurons. These interactions are crucial to the development, structural integrity and function of the cerebral microvascular endothelium. Dysfunctional blood-brain barrier has been associated with pathologies such as acute stroke, tumors, inflammatory and neurodegenerative diseases.

  11. Blood-brain barrier permeability imaging using perfusion computed tomography

    OpenAIRE

    Avsenik Jernej; Bisdas Sotirios; Popovic Katarina Surlan

    2015-01-01

    Background. The blood-brain barrier represents the selective diffusion barrier at the level of the cerebral microvascular endothelium. Other functions of blood-brain barrier include transport, signaling and osmoregulation. Endothelial cells interact with surrounding astrocytes, pericytes and neurons. These interactions are crucial to the development, structural integrity and function of the cerebral microvascular endothelium. Dysfunctional blood-brain barrier has been associated with patholog...

  12. Smart Grids – selected objectives and directions of distribution system operator actions

    Directory of Open Access Journals (Sweden)

    Rafał Czyżewski

    2012-03-01

    Full Text Available The paper presents various aspects of the implementation of Smart Grids from the distribution system operator standpoint. It discusses legal conditions of the Smart Grids implementation and their impact on the implementation timing. It describes the current state of the distribution grid and operations management systems infrastructure, indicating the desired direction of their development. It describes the preferred model of interrelations between grid operators and other key stakeholders, especially in the context of the expected establishment of balancing areas. It points out to the relevance of standardization and to the assurance of security of implemented Smart Grid solutions. It also specifies the barriers, which in the authors’ opinion could impede the Smart Grids deployment.

  13. Cylindrical air flow reversal barrier

    Energy Technology Data Exchange (ETDEWEB)

    Woznica, C.; Rodziewicz, M.

    1988-06-01

    Describes an innovative design introduced in the ZMP mine in Zory for quick reversal of ventilation air flow. Geologic mining conditions at the 705 m deep horizon, where the barrier was built, are described. According to the design used until now, a reversal system consisted of safety barriers, ventilation air locks, a ventilation bridge and stopping needed in case of a fire when air flow direction must be reversed. Nine air locks and an expensive concrete ventilation bridge were needed and the air locks had to be operated at 8 points of the region to effect reversal. The new design consists of a 2-storey cylindrical barrier which also fulfills the function of a ventilation bridge. It can be manually or remotely operated by a mechanical or pneumatic system. Tests showed that the new barrier permits immediate air flow reversal while retaining 60% of the original air, which is important in the case of fire and methane hazards. It permits improved seam panelling and splitting of pillars and brings an economy of about 40 million zlotys in construction cost. Design and operation of the barrier is illustrated and ventilation air circulation is explained. 7 figs.

  14. A versatile selection system for folding competent proteins using genetic complementation in a eukaryotic host

    DEFF Research Database (Denmark)

    Lyngsø, C.; Kjaerulff, S.; Muller, S.;

    2010-01-01

    in vivo selection system for folded proteins. It is based on genetic complementation of the Schizosaccharomyces pombe growth marker gene invertase fused C-terminally to a protein library. The fusion proteins are directed to the secretion system, utilizing the ability of the eukaryotic protein quality...

  15. Participatory definition of breeding objectives and selection indexes for sheep breeding in traditional systems

    NARCIS (Netherlands)

    Gizaw, S.; Lemma, S.; Komen, J.; Arendonk, van J.A.M.

    2010-01-01

    A farmer participatory approach was used to define breeding objectives and selection indexes for short-fat-tailed sheep in sheep–barley systems and Black Head Somali sheep in pastoral systems in Ethiopia. Breeding-objective traits were identified based on producers' preferences for traits collected

  16. Greedy Algorithm Applied to Relay Selection for Cooperative Communication Systems in Amplify-and-Forward Mode

    Institute of Scientific and Technical Information of China (English)

    Cheng-Ying Yang; Yi-Shan Lin; Jyh-Horng Wen

    2014-01-01

    Using a relaying system to provide spatial diversity and improve the system performance is a tendency in the wireless cooperative communications. Amplify-and-forward (AF) mode with a low complexity is easy to be implemented. Under the consideration of cooperative communication systems, the scenario includes one information source, M relay stations and N destinations. This work proposes a relay selection algorithm in the Raleigh fading channel. Based on the exhaustive search method, easily to realize, the optimal selection scheme can be found with a highly complicated calculation. In order to reduce the computational complexity, an approximate optimal solution with a greedy algorithm applied for the relay station selection is proposed. With different situations of the communication systems, the performance evaluation obtained by both the proposed algorithm and the exhaustive search algorithm are given for comparison. It shows the proposed algorithm could provide a solution approach to the optimal one.

  17. Hybridization of natural systems with advanced treatment processes for organic micropollutant removals: new concepts in multi-barrier treatment.

    Science.gov (United States)

    Sudhakaran, Sairam; Maeng, Sung Kyu; Amy, Gary

    2013-07-01

    Organic micropollutants (OMPs) represent a major constraint in drinking water supply. In the past, emphasis has been on individual treatment processes comprising conventional treatment (coagulation, sedimentation, and filtration) followed by advanced treatment processes (adsorption, ion-exchange, oxidation, and membrane separation). With the depletion of water resources and high demand for power and chemical usage, efforts need to be made to judiciously use advanced treatment processes. There is a new interest in multiple barriers with synergies in which two coupled processes can function as a hybrid process. Within the context of this paper, the hybrid processes include a natural treatment process coupled with an advanced process. Pilot/full-scale studies have shown efficient removal of OMPs by these hybrid processes. With this hybridization, the usage of resources such as power and chemicals can be reduced. In this study, coupling/hybridization of aquifer recharge and recovery (ARR) with oxidation (O3), advanced oxidation process which involves OH radicals (AOP), nanofiltration (NF), reverse osmosis (RO) and granular activated carbon (GAC) adsorption for OMP removal was studied. O3 or AOP as a pre-treatment and GAC, NF, RO, or UV/chlorination as a post-treatment to ARR was studied. NF can be replaced by RO for removal of OMPs since studies have shown similar performance of NF to RO for removal of many OMPs, thereby reducing costs and providing a more sustainable approach.

  18. Hybridization of natural systems with advanced treatment processes for organic micropollutant removals: New concepts in multi-barrier treatment

    KAUST Repository

    Sudhakaran, Sairam

    2013-07-01

    In the past, emphasis has been on individual treatment processes comprising conventional treatment (coagulation, sedimentation, and filtration) followed by advanced treatment processes (adsorption, ion-exchange, oxidation, and membrane separation). With the depletion of water resources and high demand for power and chemical usage, efforts need to be made to judiciously use advanced treatment processes. There is a new interest in multiple barriers with synergies in which two coupled processes can function as a hybrid process. Within the context of this paper, the hybrid processes include a natural treatment process coupled with an advanced process. Pilot/full-scale studies have shown efficient removal of OMPs by these hybrid processes. With this hybridization, the usage of resources such as power and chemicals can be reduced. In this study, coupling/hybridization of aquifer recharge and recovery (ARR) with oxidation (O3), advanced oxidation process which involves OH radicals (AOP), nanofiltration (NF), reverse osmosis (RO) and granular activated carbon (GAC) adsorption for OMP removal was studied. O3 or AOP as a pre-treatment and GAC, NF, RO, or UV/chlorination as a post-treatment to ARR was studied. NF can be replaced by RO for removal of OMPs since studies have shown similar performance of NF to RO for removal of many OMPs, thereby reducing costs and providing a more sustainable approach. © 2013 Elsevier Ltd.

  19. Control configuration selection for bilinear systems via generalised Hankel interaction index array

    DEFF Research Database (Denmark)

    Shaker, Hamid Reza; Tahavori, Maryamsadat

    2015-01-01

    of the results on control configuration selection, which have been proposed so far, can only support linear systems. The proposed method supports bilinear processes, takes the effects of dynamics of the process into account and can be used to propose a richer (sparse or block diagonal) controller structure. More......Decentralised and partially decentralised control strategies are very popular in practice. To come up with a suitable decentralised or partially decentralised control structure, it is important to select the appropriate input and output pairs for control design. This procedure is called control...... configuration selection. It is well known that a suitable control configuration selection is an important prerequisite for a successful industrial control. In this paper the problem of control configuration selection for multiple-input and multiple-output (MIMO) bilinear processes is addressed. First...

  20. A Novel Method for Optimum Global Positioning System Satellite Selection Based on a Modified Genetic Algorithm.

    Science.gov (United States)

    Song, Jiancai; Xue, Guixiang; Kang, Yanan

    2016-01-01

    In this paper, a novel method for selecting a navigation satellite subset for a global positioning system (GPS) based on a genetic algorithm is presented. This approach is based on minimizing the factors in the geometric dilution of precision (GDOP) using a modified genetic algorithm (MGA) with an elite conservation strategy, adaptive selection, adaptive mutation, and a hybrid genetic algorithm that can select a subset of the satellites represented by specific numbers in the interval (4 ∼ n) while maintaining position accuracy. A comprehensive simulation demonstrates that the MGA-based satellite selection method effectively selects the correct number of optimal satellite subsets using receiver autonomous integrity monitoring (RAIM) or fault detection and exclusion (FDE). This method is more adaptable and flexible for GPS receivers, particularly for those used in handset equipment and mobile phones.