WorldWideScience

Sample records for barrier system selection

  1. Barrier Systems

    NARCIS (Netherlands)

    Heteren, S. van

    2015-01-01

    Barrier-system dynamics are a function of antecedent topography and substrate lithology, Relative sea-level (RSL) changes, sediment availability and type, climate, vegetation type and cover, and various aero- and hydrodynamic processes during fair-weather conditions and extreme events. Global change

  2. Protection against malevolent use of vehicles at Nuclear Power Plants. Vehicle barrier system selection guidance

    International Nuclear Information System (INIS)

    Nebuda, D.T.

    1994-08-01

    This manual provides a simplified procedure for selecting land vehicle barriers that will stop the design basis vehicle threat adopted by the U.S. Nuclear Regulatory Commission. Proper selection and construction of vehicle barriers should prevent intrusion of the design basis vehicle. In addition, vital safety related equipment should survive a design basis vehicle bomb attack when vehicle barriers are properly selected, sited, and constructed. This manual addresses passive vehicle barriers, active vehicle barriers, and site design features that can be used to reduce vehicle impact velocity

  3. Vehicle barrier systems

    International Nuclear Information System (INIS)

    Sena, P.A.

    1986-01-01

    The ground vehicle is one of the most effective tools available to an adversary force. Vehicles can be used to penetrate many types of perimeter barriers, transport equipment and personnel rapidly over long distances, and deliver large amounts of explosives directly to facilities in suicide missions. The function of a vehicle barrier system is to detain or disable a defined threat vehicle at a selected distance from a protected facility. Numerous facilities are installing, or planning to install, vehicle barrier systems and many of these facilities are requesting guidance to do so adequately. Therefore, vehicle barriers are being evaluated to determine their stopping capabilities so that systems can be designed that are both balanced and capable of providing a desired degree of protection. Equally important, many of the considerations that should be taken into account when establishing a vehicle barrier system have been identified. These considerations which pertain to site preparation, barrier selection, system integration and operation, and vehicle/barrier interaction, are discussed in this paper

  4. Selection of barrier metals for a waste package in tuff

    International Nuclear Information System (INIS)

    Russell, E.W.; McCright, R.D.; O'Neal, W.C.

    1983-10-01

    The Nevada Nuclear Waste Storage Investigations (NNWSI) project under the Civilian Radioactive Waste Management Program is planning a repository at Yucca Mountain at the Nevada Test Site for isolation of high-level nuclear waste. Lawrence Livermore National Laboratory is developing designs for an engineered barrier system containing several barriers such as the waste form, a canister and/or an overpack, packing, and near field host rock. In this paper we address the selection of metal containment barriers. 13 references, 4 tables

  5. Selection of barrier metals for a waste package in tuff

    International Nuclear Information System (INIS)

    Russell, E.W.; McCright, R.D.; O'Neal, W.C.

    1983-09-01

    The Nevada Nuclear Waste Storage Investigation (NNWSI) project under the Civilian Radioactive Waste Management Program is planning a repository at Yucca Mountain at the Nevada Test Site for isolation of high-level nuclear waste. LLNL is developing designs for an engineered barrier system containing several barriers such as the waste form, a canister and/or an overpack, packing, and near field host rock. The selection of metal containment barriers is addressed. 13 references

  6. Barrier rf systems in synchrotrons

    International Nuclear Information System (INIS)

    Bhat, Chandra M.

    2004-01-01

    Recently, many interesting applications of the barrier RF system in hadron synchrotrons have been realized. A remarkable example of this is the development of longitudinal momentum mining and implementation at the Fermilab Recycler for extraction of low emittance pbars for the Tevatron shots. At Fermilab, we have barrier RF systems in four different rings. In the case of Recycler Ring, all of the rf manipulations are carried out using a barrier RF system. Here, the author reviews various uses of barrier rf systems in particle accelerators including some new schemes for producing intense proton beam and possible new applications

  7. Visual selective attention with virtual barriers.

    Science.gov (United States)

    Schneider, Darryl W

    2017-07-01

    Previous studies have shown that interference effects in the flanker task are reduced when physical barriers (e.g., hands) are placed around rather than below a target flanked by distractors. One explanation of this finding is the referential coding hypothesis, whereby the barriers serve as reference objects for allocating attention. In five experiments, the generality of the referential coding hypothesis was tested by investigating whether interference effects are modulated by the placement of virtual barriers (e.g., parentheses). Modulation of flanker interference was found only when target and distractors differed in size and the virtual barriers were beveled wood-grain objects. Under these conditions and those of previous studies, the author conjectures that an impression of depth was produced when the barriers were around the target, such that the target was perceived to be on a different depth plane than the distractors. Perception of depth in the stimulus display might have led to referential coding of the stimuli in three-dimensional (3-D) space, influencing the allocation of attention beyond the horizontal and vertical dimensions. This 3-D referential coding hypothesis is consistent with research on selective attention in 3-D space that shows flanker interference is reduced when target and distractors are separated in depth.

  8. Behavior of nine selected emerging trace organic contaminants in an artificial recharge system supplemented with a reactive barrier.

    Science.gov (United States)

    Valhondo, Cristina; Carrera, Jesús; Ayora, Carlos; Barbieri, Manuela; Nödler, Karsten; Licha, Tobias; Huerta, Maria

    2014-10-01

    Artificial recharge improves several water quality parameters, but has only minor effects on recalcitrant pollutants. To improve the removal of these pollutants, we added a reactive barrier at the bottom of an infiltration basin. This barrier contained aquifer sand, vegetable compost, and clay and was covered with iron oxide dust. The goal of the compost was to sorb neutral compounds and release dissolved organic carbon. The release of dissolved organic carbon should generate a broad range of redox conditions to promote the transformation of emerging trace organic contaminants (EOCs). Iron oxides and clay increase the range of sorption site types. In the present study, we examined the effectiveness of this barrier by analyzing the fate of nine EOCs. Water quality was monitored before and after constructing the reactive barrier. Installation of the reactive barrier led to nitrate-, iron-, and manganese-reducing conditions in the unsaturated zone below the basin and within the first few meters of the saturated zone. Thus, the behavior of most EOCs changed after installing the reactive barrier. The reactive barrier enhanced the removal of some EOCs, either markedly (sulfamethoxazole, caffeine, benzoylecgonine) or slightly (trimethoprim) and decreased the removal rates of compounds that are easily degradable under aerobic conditions (ibuprofen, paracetamol). The barrier had no remarkable effect on 1H-benzotriazole and tolyltriazole.

  9. Air barrier systems: Construction applications

    Energy Technology Data Exchange (ETDEWEB)

    Perrault, J.C

    1989-01-01

    An examination is presented of how ordinary building materials can be used in an innovative manner to design, detail, and construct effective air barrier systems for common types of walls. For residential construction, the air drywall approach uses the interior gypsum board as the main component of the wall air barrier system. Joints between the gypsum board and adjacent materials or assemblies are sealed by gaskets. In commercial construction, two different techniques are employed for using gypsum board as air barrier material: the accessible drywall and non-accessible drywall approaches. The former is similar to the air drywall approach except that high performance sealants are used instead of gaskets. In the latter approach, exterior drywall sheathing is the main component of the air barrier system; joints between boards are taped and joints between boards and other components are sealed using elastomeric membrane strips. For various types of commercial and institutional buildings, metal air barrier systems are widely used and include pre-engineered curtain walls or sheet metal walls. Masonry wall systems are regarded as still the most durable, fireproof, and soundproof wall type available but an effective air barrier system has typically been difficult to implement. Factory-made elastomeric membranes offer the potential to provide airtightness to masonry walls. These membranes are applied on the entire masonry wall surface and are used to make airtight connections with other building components. Two types of product are available: thermofusible and peel-and-stick membranes. 5 figs.

  10. Selected socioeconomic barriers of education in Sub-Saharan Africa

    OpenAIRE

    Tillová, Petra

    2015-01-01

    Selected socioeconomic barriers of education in Sub-Saharan Africa Abstract The aim of bachelor thesis is to describe and understand the process of education in Sub-Saharan Africa and analyze components that cause limited access to education. The first part of the thesis describes the process of education in Sub-Saharan Africa using selected indicators. The second main part focuses on the description and possible relations between selected socioeconomic barriers and literacy. Selected barrier...

  11. Schottky barrier MOSFET systems and fabrication thereof

    Science.gov (United States)

    Welch, J.D.

    1997-09-02

    (MOS) device systems-utilizing Schottky barrier source and drain to channel region junctions are disclosed. Experimentally derived results which demonstrate operation of fabricated N-channel and P-channel Schottky barrier (MOSFET) devices, and of fabricated single devices with operational characteristics similar to (CMOS) and to a non-latching (SRC) are reported. Use of essentially non-rectifying Schottky barriers in (MOS) structures involving highly doped and the like and intrinsic semiconductor to allow non-rectifying interconnection of, and electrical accessing of device regions is also disclosed. Insulator effected low leakage current device geometries and fabrication procedures therefore are taught. Selective electrical interconnection of drain to drain, source to drain, or source to source, of N-channel and/or P-channel Schottky barrier (MOSFET) devices formed on P-type, N-type and Intrinsic semiconductor allows realization of Schottky Barrier (CMOS), (MOSFET) with (MOSFET) load, balanced differential (MOSFET) device systems and inverting and non-inverting single devices with operating characteristics similar to (CMOS), which devices can be utilized in modulation, as well as in voltage controlled switching and effecting a direction of rectification. 89 figs.

  12. Physical protection system using activated barriers

    International Nuclear Information System (INIS)

    Timm, R.E.; Zinneman, T.E.; Haumann, J.R.; Flaugher, H.A.; Reigle, D.L.

    1984-03-01

    The Argonne National Laboratory has recently installed an activated barrier, the Access Denial System, to upgrade its security. The technology of this system was developed in the late 70's by Sandia National Laboratory-Albuquerque. The Argonne National Laboratory is the first Department of Energy facility to use this device. Recent advancements in electronic components provide the total system support that makes the use of an activated barrier viable and desirable. The premise of an activated barrier is that it is deployed after a positive detection of an adversary is made and before the adversary can penetrate vital area. To accomplish this detection, sophisticated alarms, assessment, and communications must be integrated into a system that permits a security inspector to make a positive evaluation and to activate the barrier. The alarm sensor locations are selected to provide protection in depth. Closed circuit television is used with components that permit multiple video frames to be stored for automated, priority-based playback to the security inspector. Further, algorithms permit look-ahead surveillance of vital areas so that the security inspector can activate the access denial system in a timely manner and not be restricted to following the adversaries' penetration path(s)

  13. Prototype Engineered Barrier System Field Tests

    International Nuclear Information System (INIS)

    Ramirez, A.L.; Beatty, J.; Buscheck, T.A.

    1989-01-01

    This paper presents selected preliminary results obtained during the first 54 days of the Prototype Engineered Barrier System Field Tests (PEBSFT) that are being performed in G-Tunnel within the Nevada Test Site. The test described is a precursor to the Engineered Barrier Systems Field Tests (EBSFT). The EBSFT will consist of in situ tests of the geohydrologic and geochemical environment in the near field (within a few meters) of heaters emplaced in welded tuff to simulate the thermal effects of waste packages. The PEBSFTs are being conducted to evaluate the applicability of measurement techniques, numerical models, and procedures for future investigations that will be conducted in the Exploratory Shaft Facilities of the Yucca Mountain Project (YMP). The paper discusses the evolution of hydrothermal behavior during the prototype test, including rock temperatures, changes in rock moisture content, air permeability of fractures, gas pressures, and rock mass gas-phase humidity. 10 refs., 12 figs

  14. Transport barrier in Helical system

    International Nuclear Information System (INIS)

    Ida, Katsumi

    1998-01-01

    Experiments on the transport barrier in Helical plasmas are reviewed. There are two mechanisms of transport improvement, that results in the formation of the transport barrier. One is the improvement of neoclassical transport by reducing the ripple loss with radial electric field, which exist only in helical plasma. The other is the improvement of anomalous transport due to the suppression of fluctuations associated with a radial electric field shear both in tokamak and helical plasma. The formation of the transport barrier can be triggered by the radial electric field shear associated with the transition of the radial electric field (L/H transition or ion-electron root transition) or the peaked density or the optimization of magnetic field shear. The mechanisms of transport barrier formation are also discussed. (author). 60 refs

  15. Systems study on engineered barriers: barrier performance analysis

    International Nuclear Information System (INIS)

    Stula, R.T.; Albert, T.E.; Kirstein, B.E.; Lester, D.H.

    1980-09-01

    A performance assessment model for multiple barrier packages containing unreprocessed spent fuel has been modified and applied to several package designs. The objective of the study was to develop information to be used in programmatic decision making concerning engineered barrier package design and development. The assessment model, BARIER, was developed in previous tasks of the System Study on Engineered Barriers (SSEB). The new version discussed in this report contains a refined and expanded corrosion rate data base which includes pitting, crack growth, and graphitization as well as bulk corrosion. Corrosion rates for oxic and anoxic conditions at each of the two temperature ranges are supplied. Other improvements include a rigorous treatment of radionuclide release after package failure which includes resistance of damaged barriers and backfill, refined temperature calculations that account for convection and radiation, a subroutine to calculate nuclear gamma radiation field at each barrier surface, refined stress calculations with reduced conservatism and various coding improvements to improve running time and core usage. This report also contains discussion of alternative scenarios to the assumed flooded repository as well as the impact of water exclusion backfills. The model was used to assess post repository closure performance for several designs which were all variation of basic designs from the Spent Unreprocessed Fuel (SURF) program. Many designs were found to delay the onset of leaching by at least a few hundreds of years in all geologic media. Long delay times for radionuclide release were found for packages with a few inches of sorption backfill. Release of uranium, plutonium, and americium was assessed

  16. Systems study on engineered barriers: barrier performance analysis

    Energy Technology Data Exchange (ETDEWEB)

    Stula, R.T.; Albert, T.E.; Kirstein, B.E.; Lester, D.H.

    1980-09-01

    A performance assessment model for multiple barrier packages containing unreprocessed spent fuel has been modified and applied to several package designs. The objective of the study was to develop information to be used in programmatic decision making concerning engineered barrier package design and development. The assessment model, BARIER, was developed in previous tasks of the System Study on Engineered Barriers (SSEB). The new version discussed in this report contains a refined and expanded corrosion rate data base which includes pitting, crack growth, and graphitization as well as bulk corrosion. Corrosion rates for oxic and anoxic conditions at each of the two temperature ranges are supplied. Other improvements include a rigorous treatment of radionuclide release after package failure which includes resistance of damaged barriers and backfill, refined temperature calculations that account for convection and radiation, a subroutine to calculate nuclear gamma radiation field at each barrier surface, refined stress calculations with reduced conservatism and various coding improvements to improve running time and core usage. This report also contains discussion of alternative scenarios to the assumed flooded repository as well as the impact of water exclusion backfills. The model was used to assess post repository closure performance for several designs which were all variation of basic designs from the Spent Unreprocessed Fuel (SURF) program. Many designs were found to delay the onset of leaching by at least a few hundreds of years in all geologic media. Long delay times for radionuclide release were found for packages with a few inches of sorption backfill. Release of uranium, plutonium, and americium was assessed.

  17. Double barrier system for an in situ conversion process

    Science.gov (United States)

    McKinzie, Billy John [Houston, TX; Vinegar, Harold J [Bellaire, TX; Cowan, Kenneth Michael [Sugar land, TX; Deeg, Wolfgang Friedrich Johann [Houston, TX; Wong, Sau-Wai [Rijswijk, NL

    2009-05-05

    A barrier system for a subsurface treatment area is described. The barrier system includes a first barrier formed around at least a portion of the subsurface treatment area. The first barrier is configured to inhibit fluid from exiting or entering the subsurface treatment area. A second barrier is formed around at least a portion of the first barrier. A separation space exists between the first barrier and the second barrier.

  18. Advanced house air-barrier systems

    Energy Technology Data Exchange (ETDEWEB)

    Lee, R.K. [Natural Resources Canada, Ottawa, ON (Canada)

    1996-08-01

    Air barrier systems used in modern Canadian airtight homes were discussed. The Advanced Houses Program sets its airtightness requirements at 1.5 air changes per hour at 50 Pascals pressure difference (ACH{sub 5}0). In recent tests of 10 houses, it was suggested that a better airtightness level was attainable with average airtightness of about 1.0 ACH{sub 5}0. Six of the homes tested did not use the traditional polyethylene approach. Two of the houses used the airtight drywall approach, one used a foam system, and three used exterior air barriers. The advantages and disadvantages of each system was described, including cost effectiveness, cost reduction, performance and installation advantages. The confusion between an air barrier and a vapour diffusion retarder was explained. Exterior air barriers showed the greatest potential for meeting airtightness requirements at reasonable cost. 5 refs., 3 tabs.

  19. Plan for metal barrier selection and testing for NNWSI

    International Nuclear Information System (INIS)

    Halsey, W.G.; McCright, R.D.

    1987-12-01

    The Department of Energy's Nevada Nuclear Waste Storage Investigations (NNWSI) Project is evaluating a site at Yucca Mountain in Nevada as a geological repository for the storage of high-level nuclear waste. The Nuclear Waste Management Projects (NWMP) at Lawrence Livermore National Laboratory (LLNL) has the responsibility for design, testing, and performance analysis of the NNWSI waste packages. One portion of this work is the selection and testing of the material for container construction. The anticipated container design is for this material to be a corrosion resistant metal called the metal barrier. This document is the publication version of the Scientific Investigation Plan (SIP) for the Metal Barrier Selection and Testing Task. The SIP serves as a formal planning document for the investigation and is used to assign quality assurance levels to the activities of the task. This document is an informal version for information distribution and has the sections on ''Schedule and Milestones'' and the ''Quality Assurance Level Assignment Sheets'' removed

  20. Cost and effectiveness of radon barrier systems

    International Nuclear Information System (INIS)

    Baker, E.G.; Freeman, H.D.; Hartley, J.N.; Gee, G.W.

    1982-12-01

    Earthen, asphalt, and multilayer radon barrier systems can all provide reduction in the amount of radon gas released from uranium mill tailings. Pacific Northwest Laboratory field tested all three types of covers at Grand Junction, Colorado during the summer of 1981. All nine individual radon barrier systems tested currently meet the EPA standard for radon flux of 20 pCi m - 2 s - 1 . The cost of the asphalt and 3m earthen covers were about the same at the field test. Multilayer covers were significantly more costly. Cost estimates for three high priority western sites indicate 3m of earthen cover is the least costly radon barrier when earthen material is available at or near the disposal site. If earthen material must be imported more than 8 to 10 km asphalt and possibly multilayer radon barriers can be cost effective

  1. Vulnerability of multiple-barrier systems

    International Nuclear Information System (INIS)

    Lind, N.C.

    1996-01-01

    'Vulnerability' is defined as the ratio of the probability of failure of a damaged system to the probability of failure of the undamaged system. This definition applies to all engineered systems and can be specialized to particular system types. Some disastrous failures (e.g., Chernobyl) have shown that systems can be highly vulnerable. open-quotes Defense in depthclose quotes is a powerful design principle, reducing vulnerability when the consequences of failure can be catastrophic. In the nuclear industry, defense in depth is widely used in radiation protection, reactor control, and shutdown systems. A multiple-barrier system is a simple example of a system that has defense in depth. The idea is that the system is not vulnerable. It cannot fail if one barrier fails because there is another to take its place. This idea is untenable in waste management, but a quantified vulnerability of a system can help owners, designers, and regulators decide how much defense in depth is desirable or enough. Many multiple-barrier systems can be modeled as systems of components physically in a series, each individually able to prevent failure. Components typically have bimodal distributions of the service time to failure, as illustrated by an example of application to a hypothetical nuclear fuel waste repository

  2. Engineered Barrier System: Physical and Chemical Environment

    International Nuclear Information System (INIS)

    Dixon, P.

    2004-01-01

    The conceptual and predictive models documented in this Engineered Barrier System: Physical and Chemical Environment Model report describe the evolution of the physical and chemical conditions within the waste emplacement drifts of the repository. The modeling approaches and model output data will be used in the total system performance assessment (TSPA-LA) to assess the performance of the engineered barrier system and the waste form. These models evaluate the range of potential water compositions within the emplacement drifts, resulting from the interaction of introduced materials and minerals in dust with water seeping into the drifts and with aqueous solutions forming by deliquescence of dust (as influenced by atmospheric conditions), and from thermal-hydrological-chemical (THC) processes in the drift. These models also consider the uncertainty and variability in water chemistry inside the drift and the compositions of introduced materials within the drift. This report develops and documents a set of process- and abstraction-level models that constitute the engineered barrier system: physical and chemical environment model. Where possible, these models use information directly from other process model reports as input, which promotes integration among process models used for total system performance assessment. Specific tasks and activities of modeling the physical and chemical environment are included in the technical work plan ''Technical Work Plan for: In-Drift Geochemistry Modeling'' (BSC 2004 [DIRS 166519]). As described in the technical work plan, the development of this report is coordinated with the development of other engineered barrier system analysis model reports

  3. Engineered Barrier System: Physical and Chemical Environment

    Energy Technology Data Exchange (ETDEWEB)

    P. Dixon

    2004-04-26

    The conceptual and predictive models documented in this Engineered Barrier System: Physical and Chemical Environment Model report describe the evolution of the physical and chemical conditions within the waste emplacement drifts of the repository. The modeling approaches and model output data will be used in the total system performance assessment (TSPA-LA) to assess the performance of the engineered barrier system and the waste form. These models evaluate the range of potential water compositions within the emplacement drifts, resulting from the interaction of introduced materials and minerals in dust with water seeping into the drifts and with aqueous solutions forming by deliquescence of dust (as influenced by atmospheric conditions), and from thermal-hydrological-chemical (THC) processes in the drift. These models also consider the uncertainty and variability in water chemistry inside the drift and the compositions of introduced materials within the drift. This report develops and documents a set of process- and abstraction-level models that constitute the engineered barrier system: physical and chemical environment model. Where possible, these models use information directly from other process model reports as input, which promotes integration among process models used for total system performance assessment. Specific tasks and activities of modeling the physical and chemical environment are included in the technical work plan ''Technical Work Plan for: In-Drift Geochemistry Modeling'' (BSC 2004 [DIRS 166519]). As described in the technical work plan, the development of this report is coordinated with the development of other engineered barrier system analysis model reports.

  4. Recognizing the Effects of Comprehension Language Barriers and Adaptability Cultural Barriers on Selected First-Generation Undergraduate Vietnamese Students

    Science.gov (United States)

    Phan, Christian Phuoc-Lanh

    2009-01-01

    This investigation is about recognizing the effects of comprehension language barriers and adaptability cultural barriers on selected first-generation Vietnamese undergraduate students in the Puget Sound region of Washington State. Most Vietnamese students know little or no English before immigrating to the United States; as such, language and…

  5. ENGINEERED BARRIER SYSTEM: PHYSICAL AND CHEMICAL ENVIRONMENT

    Energy Technology Data Exchange (ETDEWEB)

    R. Jarek

    2004-11-23

    The purpose of this report is to describe the evolution of the physical and chemical environmental conditions within the waste emplacement drifts of the repository, including the drip shield and waste package surfaces. The abstraction model is used in the total system performance assessment for the license application (TSPA LA) to assess the performance of the engineered barrier system and the waste form. This report develops and documents a set of these abstraction-level models that describe the engineered barrier system physical and chemical environment. Where possible, these models use information directly from other reports as input, which promotes integration among process models used for TSPA-LA. Specific tasks and activities of modeling the physical and chemical environment are included in ''Technical Work Plan for: Near-Field Environment and Transport In-Drift Geochemistry Model Report Integration'' (BSC 2004 [DIRS 171156], Section 1.2.2). As described in the technical work plan, the development of this report is coordinated with the development of other engineered barrier system reports.

  6. ENGINEERED BARRIER SYSTEM: PHYSICAL AND CHEMICAL ENVIRONMENT

    International Nuclear Information System (INIS)

    Jarek, R.

    2004-01-01

    The purpose of this report is to describe the evolution of the physical and chemical environmental conditions within the waste emplacement drifts of the repository, including the drip shield and waste package surfaces. The abstraction model is used in the total system performance assessment for the license application (TSPA LA) to assess the performance of the engineered barrier system and the waste form. This report develops and documents a set of these abstraction-level models that describe the engineered barrier system physical and chemical environment. Where possible, these models use information directly from other reports as input, which promotes integration among process models used for TSPA-LA. Specific tasks and activities of modeling the physical and chemical environment are included in ''Technical Work Plan for: Near-Field Environment and Transport In-Drift Geochemistry Model Report Integration'' (BSC 2004 [DIRS 171156], Section 1.2.2). As described in the technical work plan, the development of this report is coordinated with the development of other engineered barrier system reports

  7. ENGINEERED BARRIER SYSTEM: PHYSICAL AND CHEMICAL ENVIRONMENT

    International Nuclear Information System (INIS)

    G.H. Nieder-Westermann

    2005-01-01

    The purpose of this report is to describe the evolution of the physical and chemical environmental conditions within the waste emplacement drifts of the repository, including the drip shield and waste package surfaces. The abstraction model is used in the total system performance assessment for the license application (TSPA LA) to assess the performance of the engineered barrier system and the waste form. This report develops and documents a set of these abstraction-level models that describe the engineered barrier system physical and chemical environment. Where possible, these models use information directly from other reports as input, which promotes integration among process models used for TSPA-LA. Specific tasks and activities of modeling the physical and chemical environment are included in ''Technical Work Plan for: Near-Field Environment and Transport In-Drift Geochemistry Model Report Integration'' (BSC 2004 [DIRS 171156], Section 1.2.2). As described in the technical work plan, the development of this report is coordinated with the development of other engineered barrier system reports

  8. ENGINEERED BARRIER SYSTEM: PHYSICAL AND CHEMICAL ENVIRONMENT

    Energy Technology Data Exchange (ETDEWEB)

    G.H. Nieder-Westermann

    2005-04-07

    The purpose of this report is to describe the evolution of the physical and chemical environmental conditions within the waste emplacement drifts of the repository, including the drip shield and waste package surfaces. The abstraction model is used in the total system performance assessment for the license application (TSPA LA) to assess the performance of the engineered barrier system and the waste form. This report develops and documents a set of these abstraction-level models that describe the engineered barrier system physical and chemical environment. Where possible, these models use information directly from other reports as input, which promotes integration among process models used for TSPA-LA. Specific tasks and activities of modeling the physical and chemical environment are included in ''Technical Work Plan for: Near-Field Environment and Transport In-Drift Geochemistry Model Report Integration'' (BSC 2004 [DIRS 171156], Section 1.2.2). As described in the technical work plan, the development of this report is coordinated with the development of other engineered barrier system reports.

  9. Selecting a silvicultural system

    Science.gov (United States)

    Richard M. Godman

    1992-01-01

    Sometimes a name creates a problem. The name of a silvicultural system usually refers to the way a stand is cut to get regeneration-"single tree selection"-for example. Trouble is, the name suggests that the regeneration cut will be the first treatment applied to the stand. Not so. We are now mostly making "intermediate" cuts in our Lake States...

  10. Engineered Barrier System Degradation, Flow, and Transport Process Model Report

    Energy Technology Data Exchange (ETDEWEB)

    E.L. Hardin

    2000-07-17

    The Engineered Barrier System Degradation, Flow, and Transport Process Model Report (EBS PMR) is one of nine PMRs supporting the Total System Performance Assessment (TSPA) being developed by the Yucca Mountain Project for the Site Recommendation Report (SRR). The EBS PMR summarizes the development and abstraction of models for processes that govern the evolution of conditions within the emplacement drifts of a potential high-level nuclear waste repository at Yucca Mountain, Nye County, Nevada. Details of these individual models are documented in 23 supporting Analysis/Model Reports (AMRs). Nineteen of these AMRs are for process models, and the remaining 4 describe the abstraction of results for application in TSPA. The process models themselves cluster around four major topics: ''Water Distribution and Removal Model, Physical and Chemical Environment Model, Radionuclide Transport Model, and Multiscale Thermohydrologic Model''. One AMR (Engineered Barrier System-Features, Events, and Processes/Degradation Modes Analysis) summarizes the formal screening analysis used to select the Features, Events, and Processes (FEPs) included in TSPA and those excluded from further consideration. Performance of a potential Yucca Mountain high-level radioactive waste repository depends on both the natural barrier system (NBS) and the engineered barrier system (EBS) and on their interactions. Although the waste packages are generally considered as components of the EBS, the EBS as defined in the EBS PMR includes all engineered components outside the waste packages. The principal function of the EBS is to complement the geologic system in limiting the amount of water contacting nuclear waste. A number of alternatives were considered by the Project for different EBS designs that could provide better performance than the design analyzed for the Viability Assessment. The design concept selected was Enhanced Design Alternative II (EDA II).

  11. Engineered Barrier System Degradation, Flow, and Transport Process Model Report

    International Nuclear Information System (INIS)

    E.L. Hardin

    2000-01-01

    The Engineered Barrier System Degradation, Flow, and Transport Process Model Report (EBS PMR) is one of nine PMRs supporting the Total System Performance Assessment (TSPA) being developed by the Yucca Mountain Project for the Site Recommendation Report (SRR). The EBS PMR summarizes the development and abstraction of models for processes that govern the evolution of conditions within the emplacement drifts of a potential high-level nuclear waste repository at Yucca Mountain, Nye County, Nevada. Details of these individual models are documented in 23 supporting Analysis/Model Reports (AMRs). Nineteen of these AMRs are for process models, and the remaining 4 describe the abstraction of results for application in TSPA. The process models themselves cluster around four major topics: ''Water Distribution and Removal Model, Physical and Chemical Environment Model, Radionuclide Transport Model, and Multiscale Thermohydrologic Model''. One AMR (Engineered Barrier System-Features, Events, and Processes/Degradation Modes Analysis) summarizes the formal screening analysis used to select the Features, Events, and Processes (FEPs) included in TSPA and those excluded from further consideration. Performance of a potential Yucca Mountain high-level radioactive waste repository depends on both the natural barrier system (NBS) and the engineered barrier system (EBS) and on their interactions. Although the waste packages are generally considered as components of the EBS, the EBS as defined in the EBS PMR includes all engineered components outside the waste packages. The principal function of the EBS is to complement the geologic system in limiting the amount of water contacting nuclear waste. A number of alternatives were considered by the Project for different EBS designs that could provide better performance than the design analyzed for the Viability Assessment. The design concept selected was Enhanced Design Alternative II (EDA II)

  12. Vibration behavior of the artificial barrier system

    International Nuclear Information System (INIS)

    Mikoshiba, Tadashi; Ogawa, Nobuyuki; Nakamura, Izuru

    2000-01-01

    This study aims at production of a mimic specimen of artificial barrier, experimental elucidation of influence of seismic motion due to a vibration experiment on the artificial barrier system, and establishment of an evaluating method on its long-term behavior. The study has been carried out under a cooperative study of the National Research Institute for Earth Science and Disaster Prevention and the Japan Nuclear Cycle Development Institute. In 1998 fiscal year, an artificial barrier specimen initiated by crosscut road was produced, and their random wave and actual seismic wave vibrations were carried out to acquire their fundamental data. As a result of the both vibrations, it was found that in a Case 2 specimen of which buffer material was swelled by poured water, the material was integrated with a mimic over-pack to vibrate under judgement of eigen-frequency, maximum acceleration ratio, and so forth on the test results. And, in a Case 1 specimen, it was thought that the mimic over-pack showed an extreme non-linear performance (soft spring) because of reducing eigen-frequency with increase of its vibration level. (G.K.)

  13. Vibration behavior of the artificial barrier system

    Energy Technology Data Exchange (ETDEWEB)

    Mikoshiba, Tadashi; Ogawa, Nobuyuki; Nakamura, Izuru [National Research Inst. for Earth sceince and Disaster Prevention (Japan)

    2000-02-01

    This study aims at production of a mimic specimen of artificial barrier, experimental elucidation of influence of seismic motion due to a vibration experiment on the artificial barrier system, and establishment of an evaluating method on its long-term behavior. The study has been carried out under a cooperative study of the National Research Institute for Earth Science and Disaster Prevention and the Japan Nuclear Cycle Development Institute. In 1998 fiscal year, an artificial barrier specimen initiated by crosscut road was produced, and their random wave and actual seismic wave vibrations were carried out to acquire their fundamental data. As a result of the both vibrations, it was found that in a Case 2 specimen of which buffer material was swelled by poured water, the material was integrated with a mimic over-pack to vibrate under judgement of eigen-frequency, maximum acceleration ratio, and so forth on the test results. And, in a Case 1 specimen, it was thought that the mimic over-pack showed an extreme non-linear performance (soft spring) because of reducing eigen-frequency with increase of its vibration level. (G.K.)

  14. Reliability modeling of an engineered barrier system

    International Nuclear Information System (INIS)

    Ananda, M.M.A.; Singh, A.K.; Flueck, J.A.

    1993-01-01

    The Weibull distribution is widely used in reliability literature as a distribution of time to failure, as it allows for both increasing failure rate (IFR) and decreasing failure rate (DFR) models. It has also been used to develop models for an engineered barrier system (EBS), which is known to be one of the key components in a deep geological repository for high level radioactive waste (HLW). The EBS failure time can more realistically be modelled by an IFR distribution, since the failure rate for the EBS is not expected to decrease with time. In this paper, we use an IFR distribution to develop a reliability model for the EBS

  15. Reliability modeling of an engineered barrier system

    International Nuclear Information System (INIS)

    Ananda, M.M.A.; Singh, A.K.; Flueck, J.A.

    1993-01-01

    The Weibull distribution is widely used in reliability literature as a distribution of time to failure, as it allows for both increasing failure rate (IFR) and decreasing failure rate (DFR) models. It has also been used to develop models for an engineered barrier system (EBS), which is known to be one of the key components in a deep geological repository for high level radioactive waste (HLW). The EBS failure time can more realistically be modelled by an IFR distribution, since the failure rate for the EBS is not expected to decrease with time. In this paper, an IFR distribution is used to develop a reliability model for the EBS

  16. Analysis of developed transition road safety barrier systems.

    Science.gov (United States)

    Soltani, Mehrtash; Moghaddam, Taher Baghaee; Karim, Mohamed Rehan; Sulong, N H Ramli

    2013-10-01

    Road safety barriers protect vehicles from roadside hazards by redirecting errant vehicles in a safe manner as well as providing high levels of safety during and after impact. This paper focused on transition safety barrier systems which were located at the point of attachment between a bridge and roadside barriers. The aim of this study was to provide an overview of the behavior of transition systems located at upstream bridge rail with different designs and performance levels. Design factors such as occupant risk and vehicle trajectory for different systems were collected and compared. To achieve this aim a comprehensive database was developed using previous studies. The comparison showed that Test 3-21, which is conducted by impacting a pickup truck with speed of 100 km/h and angle of 25° to transition system, was the most severe test. Occupant impact velocity and ridedown acceleration for heavy vehicles were lower than the amounts for passenger cars and pickup trucks, and in most cases higher occupant lateral impact ridedown acceleration was observed on vehicles subjected to higher levels of damage. The best transition system was selected to give optimum performance which reduced occupant risk factors using the similar crashes in accordance with Test 3-21. Copyright © 2013 Elsevier Ltd. All rights reserved.

  17. Article Including Environmental Barrier Coating System

    Science.gov (United States)

    Lee, Kang N. (Inventor)

    2015-01-01

    An enhanced environmental barrier coating for a silicon containing substrate. The enhanced barrier coating may include a bond coat doped with at least one of an alkali metal oxide and an alkali earth metal oxide. The enhanced barrier coating may include a composite mullite bond coat including BSAS and another distinct second phase oxide applied over said surface.

  18. ENGINEERED BARRIER SYSTEM: PHYSICAL AND CHEMICAL ENVIRONMENT

    Energy Technology Data Exchange (ETDEWEB)

    R. Jarek

    2005-08-29

    The purpose of this model report is to describe the evolution of the physical and chemical environmental conditions within the waste emplacement drifts of the repository, including the drip shield and waste package surfaces. The resulting seepage evaporation and gas abstraction models are used in the total system performance assessment for the license application (TSPA-LA) to assess the performance of the engineered barrier system and the waste form. This report develops and documents a set of abstraction-level models that describe the engineered barrier system physical and chemical environment. Where possible, these models use information directly from other reports as input, which promotes integration among process models used for TSPA-LA. Specific tasks and activities of modeling the physical and chemical environment are included in ''Technical Work Plan for: Near-Field Environment and Transport In-Drift Geochemistry Model Report Integration'' (BSC 2005 [DIRS 173782], Section 1.2.2). As described in the technical work plan, the development of this report is coordinated with the development of other engineered barrier system reports. To be consistent with other project documents that address features, events, and processes (FEPs), Table 6.14.1 of the current report includes updates to FEP numbers and FEP subjects for two FEPs identified in the technical work plan (TWP) governing this report (BSC 2005 [DIRS 173782]). FEP 2.1.09.06.0A (Reduction-oxidation potential in EBS), as listed in Table 2 of the TWP (BSC 2005 [DIRS 173782]), has been updated in the current report to FEP 2.1.09.06.0B (Reduction-oxidation potential in Drifts; see Table 6.14-1). FEP 2.1.09.07.0A (Reaction kinetics in EBS), as listed in Table 2 of the TWP (BSC 2005 [DIRS 173782]), has been updated in the current report to FEP 2.1.09.07.0B (Reaction kinetics in Drifts; see Table 6.14-1). These deviations from the TWP are justified because they improve integration with FEPs

  19. ENGINEERED BARRIER SYSTEM: PHYSICAL AND CHEMICAL ENVIRONMENT

    International Nuclear Information System (INIS)

    R. Jarek

    2005-01-01

    The purpose of this model report is to describe the evolution of the physical and chemical environmental conditions within the waste emplacement drifts of the repository, including the drip shield and waste package surfaces. The resulting seepage evaporation and gas abstraction models are used in the total system performance assessment for the license application (TSPA-LA) to assess the performance of the engineered barrier system and the waste form. This report develops and documents a set of abstraction-level models that describe the engineered barrier system physical and chemical environment. Where possible, these models use information directly from other reports as input, which promotes integration among process models used for TSPA-LA. Specific tasks and activities of modeling the physical and chemical environment are included in ''Technical Work Plan for: Near-Field Environment and Transport In-Drift Geochemistry Model Report Integration'' (BSC 2005 [DIRS 173782], Section 1.2.2). As described in the technical work plan, the development of this report is coordinated with the development of other engineered barrier system reports. To be consistent with other project documents that address features, events, and processes (FEPs), Table 6.14.1 of the current report includes updates to FEP numbers and FEP subjects for two FEPs identified in the technical work plan (TWP) governing this report (BSC 2005 [DIRS 173782]). FEP 2.1.09.06.0A (Reduction-oxidation potential in EBS), as listed in Table 2 of the TWP (BSC 2005 [DIRS 173782]), has been updated in the current report to FEP 2.1.09.06.0B (Reduction-oxidation potential in Drifts; see Table 6.14-1). FEP 2.1.09.07.0A (Reaction kinetics in EBS), as listed in Table 2 of the TWP (BSC 2005 [DIRS 173782]), has been updated in the current report to FEP 2.1.09.07.0B (Reaction kinetics in Drifts; see Table 6.14-1). These deviations from the TWP are justified because they improve integration with FEPs documents. The updates

  20. International Collaboration Activities on Engineered Barrier Systems

    Energy Technology Data Exchange (ETDEWEB)

    Jove-Colon, Carlos F. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-08-31

    The Used Fuel Disposition Campaign (UFDC) within the DOE Fuel Cycle Technologies (FCT) program has been engaging in international collaborations between repository R&D programs for high-level waste (HLW) disposal to leverage on gathered knowledge and laboratory/field data of near- and far-field processes from experiments at underground research laboratories (URL). Heater test experiments at URLs provide a unique opportunity to mimetically study the thermal effects of heat-generating nuclear waste in subsurface repository environments. Various configurations of these experiments have been carried out at various URLs according to the disposal design concepts of the hosting country repository program. The FEBEX (Full-scale Engineered Barrier Experiment in Crystalline Host Rock) project is a large-scale heater test experiment originated by the Spanish radioactive waste management agency (Empresa Nacional de Residuos Radiactivos S.A. – ENRESA) at the Grimsel Test Site (GTS) URL in Switzerland. The project was subsequently managed by CIEMAT. FEBEX-DP is a concerted effort of various international partners working on the evaluation of sensor data and characterization of samples obtained during the course of this field test and subsequent dismantling. The main purpose of these field-scale experiments is to evaluate feasibility for creation of an engineered barrier system (EBS) with a horizontal configuration according to the Spanish concept of deep geological disposal of high-level radioactive waste in crystalline rock. Another key aspect of this project is to improve the knowledge of coupled processes such as thermal-hydro-mechanical (THM) and thermal-hydro-chemical (THC) operating in the near-field environment. The focus of these is on model development and validation of predictions through model implementation in computational tools to simulate coupled THM and THC processes.

  1. A chromia forming thermal barrier coating system

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, M.P.; Evans, H.E. [Metallurgy and Materials, The University of Birmingham, Birmingham, B15 2TT (United Kingdom); Gray, S.; Nicholls, J.R. [Surface Science and Engineering Centre, Cranfield University, Cranfield, MK43 0AL (United Kingdom)

    2011-07-15

    Conventional thermal barrier coating (TBC) systems consist of an insulating ceramic topcoat, a bond coat for oxidation protection and the underlying superalloy designed to combat the oxidising conditions in aero- and land-based gas turbines. Under high-temperature oxidation, the use of an alumina forming bond coat is warranted, thus all current TBC systems are optimised for the early formation of a dense, protective thermally grown oxide (TGO) of alumina. This also offers protection against Type I hot corrosion but a chromia layer gives better protection against Type II corrosion and intermediate temperatures, the conditions found in land-based gas turbines. In this paper the authors present the first known results for a chromia forming TBC system. Tests have been performed under oxidising conditions, up to 1000 h, at temperatures between 750 C and 900 C, and under Type I (900 C) and Type II (700 C) hot corrosion conditions up to 500 h. Under all these conditions no cracking, spallation or degradation was observed. Examination showed the formation of an adherent, dense chromia TGO at the bond coat / topcoat interface. These initial results are very encouraging and the TGO thicknesses agree well with comparable results reported in the literature. (Copyright copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  2. Design of barrier bucket kicker control system

    Science.gov (United States)

    Ni, Fa-Fu; Wang, Yan-Yu; Yin, Jun; Zhou, De-Tai; Shen, Guo-Dong; Zheng, Yang-De.; Zhang, Jian-Chuan; Yin, Jia; Bai, Xiao; Ma, Xiao-Li

    2018-05-01

    The Heavy-Ion Research Facility in Lanzhou (HIRFL) contains two synchrotrons: the main cooler storage ring (CSRm) and the experimental cooler storage ring (CSRe). Beams are extracted from CSRm, and injected into CSRe. To apply the Barrier Bucket (BB) method on the CSRe beam accumulation, a new BB technology based kicker control system was designed and implemented. The controller of the system is implemented using an Advanced Reduced Instruction Set Computer (RISC) Machine (ARM) chip and a field-programmable gate array (FPGA) chip. Within the architecture, ARM is responsible for data presetting and floating number arithmetic processing. The FPGA computes the RF phase point of the two rings and offers more accurate control of the time delay. An online preliminary experiment on HIRFL was also designed to verify the functionalities of the control system. The result shows that the reference trigger point of two different sinusoidal RF signals for an arbitrary phase point was acquired with a matched phase error below 1° (approximately 2.1 ns), and the step delay time better than 2 ns were realized.

  3. Prototype Engineered Barrier System Field Tests (PEBSFT)

    International Nuclear Information System (INIS)

    Ramirez, A.L.; Wilder, D.G.

    1991-02-01

    This progress report presents the interpretation of data obtained (up to November 1, 1988) from the Prototype Engineered Barrier System Field Tests (PEBSFT) that are being performed for the Yucca Mountain Project (YMP) in G-Tunnel within the Nevada Test site. The PEBSFTs are being conducted to evaluate the applicability of measurement techniques, numerical models, and procedures developed for the field tests for future investigations that will be conducted in the Exploratory Shaft Facilities, at a potential high-level radioactive waste repository site in Yucca Mountain. The primary objective of the tests is to provide the basis for determining whether tests planned for Yucca Mountain have the potential to be successful. Thirteen chapters discuss the following: mapping the electromagnetic permittivity and attenuation rate of the rock mass; changes in moisture content detected by the neutron logging probe; characterization of the in-situ permeability of the fractured tuff around the heater borehole; electrical resistance heater installed in a 30-cm borehole; relative humidity measurements; the operation, design, construction, calibration, and installation of a microwave circuit that might provide partial pressure information at temperatures in excess of 200 degree C (392 degree F); pressure and temperature measurements in the G-Tunnel; the moisture collection system, which attempts to collect steam that migrates into the heater borehole; The borehole television and borescope surveys that were performed to map the location, orientation, and aperture of the fractures intersecting the boreholes; preliminary scoping calculations of the hydrothermal conditions expected for this prototype test; the Data Acquisition System; and the results of the PEBSFT, preliminary interpretations of these results, and plans for the remainder of the test. Chapters have been indexed separately for inclusion on the data base

  4. Prototype Engineered Barrier System Field Test (PEBSFT)

    International Nuclear Information System (INIS)

    Ramirez, A.L.; Buscheck, T.; Carlson, R.; Daily, W.; Lee, K.; Lin, Wunan; Mao, Nai-hsien; Ueng, Tzou-Shin; Wang, H.; Watwood, D.

    1991-08-01

    This final report represents a summary of data and interpretations obtained from the Prototype Engineered Barrier System Field Test (PEBSFT) performed in G-Tunnel within the Nevada Test Site. The PEBSFT was conducted to evaluate the applicability of measurement techniques, numerical models, and procedures developed for future field tests that will be conducted in the Exploratory Studies Facilities (ESF) at Yucca Mountain. The primary objective of the test was to provide a basis for determining whether tests planned for the ESF have the potential to be successful. Chapter 1 on high frequency electromagnetic tomography discusses the rock mass electromagnetic permittivity and attenuation rate changes that were measured to characterize the water distribution in the near field of a simulated waste container. The data are used to obtain quantitative estimates of how the moisture content in the rock mass changes during heating and to infer properties of the spatial variability of water distribution, leading to conclusions about the role of fractures in the system. Chapter 2 discusses the changes in rock moisture content detected by the neutron logging probe. Chapter 3 permeability tests discusses the characterization of the in-situ permeability of the fractured tuff around the borehole. The air permeability testing apparatus, the testing procedures, and the data analysis are presented. Chapter 4 describes the moisture collection system installed in the heater borehole to trap and measure the moisture volumes. Chapter 5 describes relative humidity measurements made with the thermocouple psychrometer and capacitance sensors. Chapter 6 discusses gas pressure measurements in the G-Tunnel, addressing the calibration and installation of piezoresistive-gaged transducers. Chapter 7 describes the calibration and installation of thermocouples for temperature measurements. Chapter 8 discusses the results of the PEBSFT

  5. Deployment Efficiency and Barrier Effectiveness Testing of a Temporary Anti-Personnel (TAP) Barrier System.

    Energy Technology Data Exchange (ETDEWEB)

    Allen, David James [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hedrick, Charles D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Martinez, Ruben [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-02-01

    This report documents tests conducted by Sandia National Laboratories (SNL) on behalf of the U.S. Department of State to evaluate a temporary anti-personnel (TAP) barrier system developed by Mitigation Technologies. For this, the SNL Denial and Structural Assessment department developed a test protocol for the evaluation of the TAP barrier system on the basis of deployment efficiency and barrier effectiveness against a riotous/mob attack threat. The test protocol was then executed by SNL personnel and the results of the testing are documented.

  6. Development and Property Evaluation of Selected HfO2-Silicon and Rare Earth-Silicon Based Bond Coats and Environmental Barrier Coating Systems for SiC/SiC Ceramic Matrix Composites

    Science.gov (United States)

    Zhu, Dongming

    2016-01-01

    Ceramic environmental barrier coatings (EBC) and SiC/SiC ceramic matrix composites (CMCs) will play a crucial role in future aircraft propulsion systems because of their ability to significantly increase engine operating temperatures, improve component durability, reduce engine weight and cooling requirements. Advanced EBC systems for SiC/SiC CMC turbine and combustor hot section components are currently being developed to meet future turbine engine emission and performance goals. One of the significant material development challenges for the high temperature CMC components is to develop prime-reliant, high strength and high temperature capable environmental barrier coating bond coat systems, since the current silicon bond coat cannot meet the advanced EBC-CMC temperature and stability requirements. In this paper, advanced NASA HfO2-Si and rare earth Si based EBC bond coat EBC systems for SiC/SiC CMC combustor and turbine airfoil applications are investigated. High temperature properties of the advanced EBC systems, including the strength, fracture toughness, creep and oxidation resistance have been studied and summarized. The advanced NASA EBC systems showed some promise to achieve 1500C temperature capability, helping enable next generation turbine engines with significantly improved engine component temperature capability and durability.

  7. Transporter-Guided Delivery of Nanoparticles to Improve Drug Permeation across Cellular Barriers and Drug Exposure to Selective Cell Types

    Directory of Open Access Journals (Sweden)

    Longfa Kou

    2018-01-01

    Full Text Available Targeted nano-drug delivery systems conjugated with specific ligands to target selective cell-surface receptors or transporters could enhance the efficacy of drug delivery and therapy. Transporters are expressed differentially on the cell-surface of different cell types, and also specific transporters are expressed at higher than normal levels in selective cell types under pathological conditions. They also play a key role in intestinal absorption, delivery via non-oral routes (e.g., pulmonary route and nasal route, and transfer across biological barriers (e.g., blood–brain barrier and blood–retinal barrier. As such, the cell-surface transporters represent ideal targets for nano-drug delivery systems to facilitate drug delivery to selective cell types under normal or pathological conditions and also to avoid off-target adverse side effects of the drugs. There is increasing evidence in recent years supporting the utility of cell-surface transporters in the field of nano-drug delivery to increase oral bioavailability, to improve transfer across the blood–brain barrier, and to enhance delivery of therapeutics in a cell-type selective manner in disease states. Here we provide a comprehensive review of recent advancements in this interesting and important area. We also highlight certain key aspects that need to be taken into account for optimal development of transporter-assisted nano-drug delivery systems.

  8. Combustion chemical vapor desposited coatings for thermal barrier coating systems

    Energy Technology Data Exchange (ETDEWEB)

    Hampikian, J.M.; Carter, W.B. [Georgia Institute of Technology, Atlanta, GA (United States)

    1995-10-01

    The new deposition process, combustion chemical vapor deposition, shows a great deal of promise in the area of thermal barrier coating systems. This technique produces dense, adherent coatings, and does not require a reaction chamber. Coatings can therefore be applied in the open atmosphere. The process is potentially suitable for producing high quality CVD coatings for use as interlayers between the bond coat and thermal barrier coating, and/or as overlayers, on top of thermal barrier coatings.

  9. Phonon tunneling through a double barrier system

    International Nuclear Information System (INIS)

    Villegas, Diosdado; León-Pérez, Fernando de; Pérez-Álvarez, R.; Arriaga, J.

    2015-01-01

    The tunneling of optical and acoustic phonons at normal incidence on a double-barrier is studied in this paper. Transmission coefficients and resonance conditions are derived theoretically under the assumption that the long-wavelength approximation is valid. It is shown that the behavior of the transmission coefficients for the symmetric double barrier has a Lorentzian form close to resonant frequencies and that Breit–Wigner's formula have a general validity in one-dimensional phonon tunneling. Authors also study the so-called generalized Hartman effect in the tunneling of long-wavelength phonons and show that this effect is a numerical artifact resulting from taking the opaque limit before exploring the variation with a finite barrier width. This study could be useful for the design of acoustic devices

  10. Phonon tunneling through a double barrier system

    Energy Technology Data Exchange (ETDEWEB)

    Villegas, Diosdado [Departamento de Física, Universidad Central “Marta Abreu” de Las Villas, CP 54830, Santa Clara, Villa Clara (Cuba); Instituto de Física, Universidad Autónoma de Puebla, 18 Sur y San Claudio, Edif. 110A, Ciudad Universitaria, 72570 Puebla (Mexico); León-Pérez, Fernando de [Centro Universitario de la Defensa de Zaragoza, Ctra. de Huesca s/n, E-50090 Zaragoza (Spain); Pérez-Álvarez, R. [Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, CP 62209 Cuernavaca (Mexico); Arriaga, J., E-mail: arriaga@ifuap.buap.mx [Instituto de Física, Universidad Autónoma de Puebla, 18 Sur y San Claudio, Edif. 110A, Ciudad Universitaria, 72570 Puebla (Mexico)

    2015-04-15

    The tunneling of optical and acoustic phonons at normal incidence on a double-barrier is studied in this paper. Transmission coefficients and resonance conditions are derived theoretically under the assumption that the long-wavelength approximation is valid. It is shown that the behavior of the transmission coefficients for the symmetric double barrier has a Lorentzian form close to resonant frequencies and that Breit–Wigner's formula have a general validity in one-dimensional phonon tunneling. Authors also study the so-called generalized Hartman effect in the tunneling of long-wavelength phonons and show that this effect is a numerical artifact resulting from taking the opaque limit before exploring the variation with a finite barrier width. This study could be useful for the design of acoustic devices.

  11. Functions of an engineered barrier system for a nuclear waste repository in basalt

    International Nuclear Information System (INIS)

    Coons, W.E.; Moore, E.L.; Smith, M.J.; Kaser, J.D.

    1980-01-01

    Defined in this document are the functions of components selected for an engineered barrier system for a nuclear waste repository in basalt. The definitions provide a focal point for barrier material research and development by delineating the purpose and operative lifetime of each component of the engineered system. A five-component system (comprised of waste form, canister, buffer, overpack, and tailored backfill) is discussed in terms of effective operation throughout the course of repository history, recognizing that the emplacement environment changes with time. While components of the system are mutually supporting, redundancy is provided by subsystems of physical and chemical barriers which act in concert with the geology to provide a formidable barrier to transport of hazardous materials to the biosphere. The operating philosophy of the conceptual engineered barrier system is clarified by examples pertinent to storage in basalt, and a technical approach to barrier design and material selection is proposed. A method for system validation and qualification is also included which considers performance criteria proposed by external agencies in conjunction with site-specific models and risk assessment to define acceptable levels of system performance

  12. ENGINEERED BARRIER SYSTEM FEATURES, EVENTS AND PROCESSES

    Energy Technology Data Exchange (ETDEWEB)

    Jaros, W.

    2005-08-30

    The purpose of this report is to evaluate and document the inclusion or exclusion of engineered barrier system (EBS) features, events, and processes (FEPs) with respect to models and analyses used to support the total system performance assessment for the license application (TSPA-LA). A screening decision, either Included or Excluded, is given for each FEP along with the technical basis for exclusion screening decisions. This information is required by the U.S. Nuclear Regulatory Commission (NRC) at 10 CFR 63.114 (d, e, and f) [DIRS 173273]. The FEPs addressed in this report deal with those features, events, and processes relevant to the EBS focusing mainly on those components and conditions exterior to the waste package and within the rock mass surrounding emplacement drifts. The components of the EBS are the drip shield, waste package, waste form, cladding, emplacement pallet, emplacement drift excavated opening (also referred to as drift opening in this report), and invert. FEPs specific to the waste package, cladding, and drip shield are addressed in separate FEP reports: for example, ''Screening of Features, Events, and Processes in Drip Shield and Waste Package Degradation'' (BSC 2005 [DIRS 174995]), ''Clad Degradation--FEPs Screening Arguments (BSC 2004 [DIRS 170019]), and Waste-Form Features, Events, and Processes'' (BSC 2004 [DIRS 170020]). For included FEPs, this report summarizes the implementation of the FEP in the TSPA-LA (i.e., how the FEP is included). For excluded FEPs, this analysis provides the technical basis for exclusion from TSPA-LA (i.e., why the FEP is excluded). This report also documents changes to the EBS FEPs list that have occurred since the previous versions of this report. These changes have resulted due to a reevaluation of the FEPs for TSPA-LA as identified in Section 1.2 of this report and described in more detail in Section 6.1.1. This revision addresses updates in Yucca Mountain Project

  13. Internal transport barrier physics in helical systems

    International Nuclear Information System (INIS)

    Yokoyama, M.; Minami, T.; Fujisawa, A.; Herranz, J.; Ida, K.; Yamagishi, O.; Yamada, H.; Maaberg, H.; Beidler, C.D.; Dinklage, A.; Estrada, T.; Castejon, F.; Murakami, S.

    2005-01-01

    The electron internal transport barrier (eITB) has been observed in wide range of helical systems, such as CHS [eg.,1], LHD [eg., 2], TJ-II [eg., 3] and W7-AS [eg., 4]. The eITB isA defined as highly peaked electron temperature (Te) profile with strongly positive radial electric field (Er) in the central region. These observations are reviewed in this paper to understand the device-independent common findings and also to draw the main differences. This is the first report from the International Stellarator Profile Database Activity. The formation of the strong central positive Er has been understood mainly as a result of the ambipolarity of neoclassical electron and ion fluxes, although some additional convective electron flux such as driven by ECRH is required in some situations. This 'neoclassical' physics peculiar to low collisional regime of helical plasmas provides the commonly observed existence of the ECRH power threshold (which is also depending on the density). This is contrastive characteristics to the ITB observed in tokamaks. The dependence of the ECRH power threshold on the magnetic configuration and on the heating scenario among these devices are currently being examined by taking the effective ripple and the trapped particle fraction as parameters to achieve the comprehensive understanding. The roles of low order rational surfaces on the onset of eITB formation and also on its radial size (location of the footpoint of the eITB) have been indicated in inward shifted configurations in LHD (depending on the relative locations of heating position and 2/1 island) and TJ-II (eITB becomes possible at higher density when 3/2 rational is introduced in the plasma core region). It is speculated that, for the latter case, the resonance causes an extra electron flux to trigger the positive Er. The interplay between low order rational surfaces and the formation of eITB still waits for the systematic experiment and theoretical analysis. The external controllability

  14. ENGINEERED BARRIER SYSTEM FEATURES, EVENTS AND PROCESSES

    International Nuclear Information System (INIS)

    Jaros, W.

    2005-01-01

    The purpose of this report is to evaluate and document the inclusion or exclusion of engineered barrier system (EBS) features, events, and processes (FEPs) with respect to models and analyses used to support the total system performance assessment for the license application (TSPA-LA). A screening decision, either Included or Excluded, is given for each FEP along with the technical basis for exclusion screening decisions. This information is required by the U.S. Nuclear Regulatory Commission (NRC) at 10 CFR 63.114 (d, e, and f) [DIRS 173273]. The FEPs addressed in this report deal with those features, events, and processes relevant to the EBS focusing mainly on those components and conditions exterior to the waste package and within the rock mass surrounding emplacement drifts. The components of the EBS are the drip shield, waste package, waste form, cladding, emplacement pallet, emplacement drift excavated opening (also referred to as drift opening in this report), and invert. FEPs specific to the waste package, cladding, and drip shield are addressed in separate FEP reports: for example, ''Screening of Features, Events, and Processes in Drip Shield and Waste Package Degradation'' (BSC 2005 [DIRS 174995]), ''Clad Degradation--FEPs Screening Arguments (BSC 2004 [DIRS 170019]), and Waste-Form Features, Events, and Processes'' (BSC 2004 [DIRS 170020]). For included FEPs, this report summarizes the implementation of the FEP in the TSPA-LA (i.e., how the FEP is included). For excluded FEPs, this analysis provides the technical basis for exclusion from TSPA-LA (i.e., why the FEP is excluded). This report also documents changes to the EBS FEPs list that have occurred since the previous versions of this report. These changes have resulted due to a reevaluation of the FEPs for TSPA-LA as identified in Section 1.2 of this report and described in more detail in Section 6.1.1. This revision addresses updates in Yucca Mountain Project (YMP) administrative procedures as they

  15. Protective barrier systems for final disposal of Hanford Waste Sites

    International Nuclear Information System (INIS)

    Phillips, S.J.; Hartley, J.N.

    1986-01-01

    A protecting barrier system is being developed for potential application in the final disposal of defense wastes at the Hanford Site. The functional requirements for the protective barrier are control of water infiltration, wind erosion, and plant and animal intrusion into the waste zone. The barrier must also be able to function without maintenance for the required time period (up to 10,000 yr). This paper summarizes the progress made and future plans in this effort to design and test protective barriers at the Hanford Site

  16. High-resolution reconstruction of a coastal barrier system

    DEFF Research Database (Denmark)

    Fruergaard, Mikkel; Andersen, Thorbjørn Joest; Nielsen, Lars Henrik

    2015-01-01

    This study presents a detailed reconstruction of the sedimentary effects of Holocene sea-level rise on a modern coastal barrier system (CBS). Increasing concern over the evolution of CBSs due to future accelerated rates of sea-level rise calls for a better understanding of coastal barriers response...... from retreat of the barrier island and probably also due to formation of a tidal inlet close to the study area. Continued transgression and shoreface retreat created a distinct hiatus and wave ravinement surface in the seaward part of the CBS before the barrier shoreline stabilised between 5.0 and 4...

  17. Using a systems engineering process to develop engineered barrier system design concepts

    International Nuclear Information System (INIS)

    Jardine, L.J.; Short, D.W.

    1991-05-01

    The methodology used to develop conceptual designs of the engineered barrier system and waste packages for a geologic repository is based on an iterative systems engineering process. The process establishes a set of general mission requirements and then conducts detailed requirements analyses using functional analyses, system concept syntheses, and trade studies identifications to develop preliminary system concept descriptions. The feasible concept descriptions are ranked based on selection factors and criteria and a set of preferred concept descriptions is then selected for further development. For each of the selected concept descriptions, a specific set of requirements, including constraints, is written to provide design guidance for the next and more detailed phase of design. The process documents all relevant waste management system requirements so that the basis and source for the specific design requirements are traceable and clearly established. Successive iterations performed during design development help to insure that workable concepts are generated to satisfy the requirements. 4 refs., 2 figs

  18. Technique Selectively Represses Immune System

    Science.gov (United States)

    ... Research Matters December 3, 2012 Technique Selectively Represses Immune System Myelin (green) encases and protects nerve fibers (brown). A new technique prevents the immune system from attacking myelin in a mouse model of ...

  19. Development of the Canadian used fuel repository engineered barrier system

    Energy Technology Data Exchange (ETDEWEB)

    Hatton, C., E-mail: chatton@nwmo.ca [Nuclear Waste Management Organization, Toronto, ON (Canada)

    2015-07-01

    The Nuclear Waste Management Organization (NWMO) is responsible for the implementation of Adaptive Phased Management (APM), the federally-approved plan for the safe long-term management of Canada's used nuclear fuel. Under the APM plan, used nuclear fuel will ultimately be placed within a deep geological repository in a suitable rock formation. In implementing APM, the NWMO is committed to ensure consistency with international best practices in the development of its repository system, including any advances in technology. In 2012, the NWMO undertook an optimization study to look at both the design and manufacture of its engineered barriers. This study looked at current technologies for the design and manufacture of used fuel containers, placement technologies, repository design, and buffer and sealing systems, while taking into consideration the state of the art worldwide in repository design and acceptance. The result of that study is the current Canadian engineered barrier system, consisting of a 2.7 tonne used fuel container with a carbon-steel core, copper-coated surface and welded spherical heads. The used fuel container is encapsulated in a bentonite buffer box at the surface and then transferred underground. Once underground, the used fuel is placed into a repository room which is cut into the rock using traditional drill-and-blast technologies. This paper explains the logic for the selection of the container and sealing system design and the development of innovative technologies for their manufacture including the use of laser welding, cold spray and pulsed-electrodeposition copper coating for the manufacture of the used fuel container, isostatic presses for the production of the one-piece bentonite blocks, and slip-skid technologies for placement into the repository. (author)

  20. Development of the Canadian used fuel repository engineered barrier system

    International Nuclear Information System (INIS)

    Hatton, C.

    2015-01-01

    The Nuclear Waste Management Organization (NWMO) is responsible for the implementation of Adaptive Phased Management (APM), the federally-approved plan for the safe long-term management of Canada's used nuclear fuel. Under the APM plan, used nuclear fuel will ultimately be placed within a deep geological repository in a suitable rock formation. In implementing APM, the NWMO is committed to ensure consistency with international best practices in the development of its repository system, including any advances in technology. In 2012, the NWMO undertook an optimization study to look at both the design and manufacture of its engineered barriers. This study looked at current technologies for the design and manufacture of used fuel containers, placement technologies, repository design, and buffer and sealing systems, while taking into consideration the state of the art worldwide in repository design and acceptance. The result of that study is the current Canadian engineered barrier system, consisting of a 2.7 tonne used fuel container with a carbon-steel core, copper-coated surface and welded spherical heads. The used fuel container is encapsulated in a bentonite buffer box at the surface and then transferred underground. Once underground, the used fuel is placed into a repository room which is cut into the rock using traditional drill-and-blast technologies. This paper explains the logic for the selection of the container and sealing system design and the development of innovative technologies for their manufacture including the use of laser welding, cold spray and pulsed-electrodeposition copper coating for the manufacture of the used fuel container, isostatic presses for the production of the one-piece bentonite blocks, and slip-skid technologies for placement into the repository. (author)

  1. Selected System Models

    Science.gov (United States)

    Schmidt-Eisenlohr, F.; Puñal, O.; Klagges, K.; Kirsche, M.

    Apart from the general issue of modeling the channel, the PHY and the MAC of wireless networks, there are specific modeling assumptions that are considered for different systems. In this chapter we consider three specific wireless standards and highlight modeling options for them. These are IEEE 802.11 (as example for wireless local area networks), IEEE 802.16 (as example for wireless metropolitan networks) and IEEE 802.15 (as example for body area networks). Each section on these three systems discusses also at the end a set of model implementations that are available today.

  2. Study on vibration behaviors of engineered barrier system

    International Nuclear Information System (INIS)

    Mikoshiba, Tadashi; Ogawa, Nobuyuki; Minowa, Chikahiro

    1998-01-01

    High-level radioactive wastes have been buried underground by packing into a strong sealed container made from carbon steel (over-pack) with buffer material (bentonite). The engineered barrier system constructed with an overpack and buffer materials must be resistant to earthquakes as well as invasion of groundwater for a long period. Therefore, seismic evaluation of barrier system for earthquakes is indispensable especially in Japan to keep its structural safety. Here, the effects of earthquake vibration on the engineered barrier systems were investigated experimentally. Random-wave vibration and practical seismic wave one were loaded for the systems and fundamental data were obtained. For the former vibration the response characteristics of both engineered barrier models constructed with overpack and bentonite were non-linear. For the latter one, the stress in bentonite was increased in proportion to the vibration level. (M.N.)

  3. Digital Manufacturing of Selective Porous Barriers in Microchannels Using Multi-Material Stereolithography

    Directory of Open Access Journals (Sweden)

    Yong Tae Kim

    2018-03-01

    Full Text Available We have developed a sequential stereolithographic co-printing process using two different resins for fabricating porous barriers in microfluidic devices. We 3D-printed microfluidic channels with a resin made of poly(ethylene glycol diacrylate (MW = 258 (PEG-DA-258, a UV photoinitiator, and a UV sensitizer. The porous barriers were created within the microchannels in a different resin made of either PEG-DA (MW = 575 (PEG-DA-575 or 40% (w/w in water PEG-DA (MW = 700 (40% PEG-DA-700. We showed selective hydrogen ion diffusion across a 3D-printed PEG-DA-575 porous barrier in a cross-channel diffusion chip by observing color changes in phenol red, a pH indicator. We also demonstrated the diffusion of fluorescein across a 3D-printed 40% PEG-DA-700 porous barrier in a symmetric-channel diffusion chip by measuring fluorescence intensity changes across the porous barrier. Creating microfluidic chips with integrated porous barriers using a semi-automated 3D printing process shortens the design and processing time, avoids assembly and bonding complications, and reduces manufacturing costs compared to micromolding processes. We believe that our digital manufacturing method for fabricating selective porous barriers provides an inexpensive, simple, convenient and reproducible route to molecule delivery in the fields of molecular filtration and cell-based microdevices.

  4. Gas permeability of bentonite barriers: development, construction and testing of a measurement system

    Directory of Open Access Journals (Sweden)

    Heraldo Nunes Pitanga

    Full Text Available Abstract This article proposes a testing device to quickly and reliably estimate the gas permeability of bentonite-based clay barriers used in landfill cover systems. The testing methodology is based on a transient gas flow regime that passes through the barrier, therefore not requiring the use of sophisticated equipment that aim to maintain constant differential pressure and measure the gas flow, common requirements for testing methods under a permanent flow regime. To confirm the feasibility of the proposed technique, tests were performed on a pure hydrated bentonite layer, which subsequently encompassed samples of geosynthetic clay liner (GCL at different moisture contents. Geosynthetic clay liners are often selected as a part of the barrier layer for cover systems in solid waste landfills to prevent infiltration of rainfall and migration of biogas into the atmosphere. The results confirmed the equipment reliability and differentiate the different responses of the gas flow barriers studied, considering their different compositions and different moistures.

  5. [Dermoepidermic junction: a selective, complex and vital barrier].

    Science.gov (United States)

    Frede, Silvia C; Dionisio de Cabalier, María E; Zaya, Alejandro; Hliba, Ernesto

    2004-01-01

    Dermoepidermic junction (DEJ) is a highly complex region, containing a great variety of cellular elements, which despite of having different embriogenesis, interact with each other, generating different substances that keep the function and homeostasis of the greatest organ of the human body. DEJ is regarded as a highly specialized basal lamina, which acts as a highly selective pathway for the migration of cells and macromolecules, inducing cellular differentiation and micro enviromental metabolism modifications. DEJ may be divided into three zones regarding the basal lamina 1--the nearest to epidermic zone, having tonofilaments and hemidesmosomes, which keep anchored basal cells. This region is limited by the lamina densa 2--the intermediate zone, represented exclusively by lamina densa and finally the lamina 3,--the third region--extends from lamina densa to the upper dermis and extracelullar matrix. Despite there is much to learn about DEJ, the knowledge about each molecule and function of every compartment will enable us to know more about the pathogenesis of several dermatologic diseases, with a great prevalence in the clinical practice.

  6. Selecting a Cable System Operator.

    Science.gov (United States)

    Cable Television Information Center, Washington, DC.

    Intended to assist franchising authorities with the process of selecting a cable television system operator from franchise applicants, this document provides a framework for analysis of individual applications. Section 1 deals with various methods which can be used to select an operator. The next section covers the application form, the vehicle a…

  7. Thermal model of attic systems with radiant barriers

    Energy Technology Data Exchange (ETDEWEB)

    Wilkes, K.E.

    1991-07-01

    This report summarizes the first phase of a project to model the thermal performance of radiant barriers. The objective of this phase of the project was to develop a refined model for the thermal performance of residential house attics, with and without radiant barriers, and to verify the model by comparing its predictions against selected existing experimental thermal performance data. Models for the thermal performance of attics with and without radiant barriers have been developed and implemented on an IBM PC/AT computer. The validity of the models has been tested by comparing their predictions with ceiling heat fluxes measured in a number of laboratory and field experiments on attics with and without radiant barriers. Cumulative heat flows predicted by the models were usually within about 5 to 10 percent of measured values. In future phases of the project, the models for attic/radiant barrier performance will be coupled with a whole-house model and further comparisons with experimental data will be made. Following this, the models will be utilized to provide an initial assessment of the energy savings potential of radiant barriers in various configurations and under various climatic conditions. 38 refs., 14 figs., 22 tabs.

  8. Selecting practice management information systems.

    Science.gov (United States)

    Worley, R; Ciotti, V

    1997-01-01

    Despite enormous advances in information systems, the process by which most medical practices select them has remained virtually unchanged for decades: the request for proposal (RFP). Unfortunately, vendors have learned ways to minimize the value of RFP checklists to where purchasers now learn little about the system functionality. The authors describe a selection methodology that replaces the RFP with scored demos, reviews of vendor user manuals and mathematically structured reference checking. In a recent selection process at a major medical center, these techniques yielded greater user buy-in and favorable contract terms as well.

  9. The role of plants on isolation barrier systems

    International Nuclear Information System (INIS)

    Link, S.O.; Downs, J.L.; Waugh, W.J.

    1994-11-01

    Surface barriers are used to isolate buried wastes from the environment. Most have been built for short-term isolation. The need to isolate radioactive wastes from the environment requires that the functional integrity of a barrier be maintained for thousands of years. Barrier function strongly depends on vegetation. Plants reduce wind and water erosion and minimize drainage, but may transport contaminants if roots extend into buried wastes. Our review of the function of plants on surface barriers focuses on the role of plants across mesic to arid environments and gives special consideration to studies done at Hanford. The Hanford Barrier Development Program was created to design and test an earthen cover system to inhibit water infiltration, plant and animal intrusion, and wind and water erosion, while isolating buried wastes for at least 1000 years. Studies at the Hanford have shown that plants will significantly interact with the barrier. Plants transpire soil water back into the atmosphere. Deep-rooted perennials best recycle water; soil water may drain through the root zone of shallow-rooted annuals. Lysimeter studies indicate that a surface layer of fine soil with deep-rooted plants precludes drainage even with three times normal precipitation. The presence of vegetation greatly reduces water and wind erosion, but deep-rooted plants pose a threat of biointrusion and contaminant transport. The Hanford barrier includes a buried rock layer and asphalt layer to prevent biointrusion

  10. Selection Method for COTS Systems

    DEFF Research Database (Denmark)

    Hedman, Jonas; Andersson, Bo

    2014-01-01

    feature behind the method is that improved understanding of organizational ‘ends’ or goals should govern the selection of a COTS system. This can also be expressed as a match or fit between ‘ends’ (e.g. improved organizational effectiveness) and ‘means’ (e.g. implementing COTS systems). This way...

  11. Decision support system to select cover systems

    International Nuclear Information System (INIS)

    Bostick, K.V.

    1995-01-01

    The objective of this technology is to provide risk managers with a defensible, objective way to select capping alternatives for remediating radioactive and mixed waste landfills. The process of selecting containment cover technologies for mixed waste landfills requires consideration of many complex and interrelated technical, regulatory, and economic issues. A Decision Support System (DSS) is needed to integrate the knowledge of experts from scientific, engineering, and management disciplines to help in selecting the best capping practice for the site

  12. Integrated control of the wastewater system – potentials and barriers

    DEFF Research Database (Denmark)

    Mollerup, Ane Loft; Grum, Morten; Muschalla, Dirk

    2013-01-01

    Applying integrated control to a sewer system and wastewater treatment plant often leads to additional benefits for both systems when compared to controlling them independently. However, barriers such as a lack of incentive for utilities to put this type of control in place mean that in practice...

  13. Annotated bibliography of selected references on shoreline barrier island deposits with emphasis on Patrick Draw Field, Sweetwater County, Wyoming

    Energy Technology Data Exchange (ETDEWEB)

    Rawn-Schatzinger, V.; Schatzinger, R.A.

    1993-07-01

    This bibliography contains 290 annotated references on barrier island and associated depositional environments and reservoirs. It is not an exhaustive compilation of all references on the subject, but rather selected papers on barrier islands, and the depositional processes of formation. Papers that examine the morphology and internal architecture of barrier island deposits, exploration and development technologies are emphasized. Papers were selected that aid in understanding reservoir architecture and engineering technologies to help maximize recovery efficiency from barrier island oil reservoirs. Barrier islands from Wyoming, Montana and the Rocky Mountains basins are extensively covered.

  14. Selection Process of ERP Systems

    OpenAIRE

    Molnár, Bálint; Szabó, Gyula; Benczúr, András

    2013-01-01

    Background: The application and introduction of ERP systems have become a central issue for management and operation of enterprises. The competition on market enforces the improvement and optimization of business processes of enterprises to increase their efficiency, effectiveness, and to manage better the resources outside the company. The primary task of ERP systems is to achieve the before-mentioned objectives. Objective: The selection of a particular ERP system has a decisive effect on th...

  15. Engineered Barrier System performance requirements systems study report. Revision 02

    Energy Technology Data Exchange (ETDEWEB)

    Balady, M.A.

    1997-01-14

    This study evaluates the current design concept for the Engineered Barrier System (EBS), in concert with the current understanding of the geologic setting to assess whether enhancements to the required performance of the EBS are necessary. The performance assessment calculations are performed by coupling the EBS with the geologic setting based on the models (some of which were updated for this study) and assumptions used for the 1995 Total System Performance Assessment (TSPA). The need for enhancements is determined by comparing the performance assessment results against the EBS related performance requirements. Subsystem quantitative performance requirements related to the EBS include the requirement to allow no more than 1% of the waste packages (WPs) to fail before 1,000 years after permanent closure of the repository, as well as a requirement to control the release rate of radionuclides from the EBS. The EBS performance enhancements considered included additional engineered components as well as evaluating additional performance available from existing design features but for which no performance credit is currently being taken.

  16. Engineered Barrier System performance requirements systems study report. Revision 02

    International Nuclear Information System (INIS)

    Balady, M.A.

    1997-01-01

    This study evaluates the current design concept for the Engineered Barrier System (EBS), in concert with the current understanding of the geologic setting to assess whether enhancements to the required performance of the EBS are necessary. The performance assessment calculations are performed by coupling the EBS with the geologic setting based on the models (some of which were updated for this study) and assumptions used for the 1995 Total System Performance Assessment (TSPA). The need for enhancements is determined by comparing the performance assessment results against the EBS related performance requirements. Subsystem quantitative performance requirements related to the EBS include the requirement to allow no more than 1% of the waste packages (WPs) to fail before 1,000 years after permanent closure of the repository, as well as a requirement to control the release rate of radionuclides from the EBS. The EBS performance enhancements considered included additional engineered components as well as evaluating additional performance available from existing design features but for which no performance credit is currently being taken

  17. Engineered barrier systems (EBS): design requirements and constraints

    International Nuclear Information System (INIS)

    2004-01-01

    A joint NEA-EC workshop entitled 'Engineered Barrier Systems: Design Requirements and Constraints' was organised in Turku, Finland on 26-29 August 2003 and hosted by Posiva Oy. The main objectives of the workshop were to promote interaction and collaboration among experts responsible for engineering design and safety assessment in order to develop a greater understanding of how to achieve the integration needed for the successful design of engineered barrier systems, and to clarify the role that an EBS can play in the overall safety case for a repository. These proceedings present the outcomes of this workshop. (author)

  18. Cost of radon-barrier systems for uranium mill tailings

    International Nuclear Information System (INIS)

    Baker, E.G.; Hartley, J.N.

    1982-08-01

    This report deals specifically with the cost of three types of radon barrier systems, earthen covers, asphalt emulsion covers, and multilayer covers, which could meet standards proposed by the Environmental Protection Agency to stabilize uranium mill tailings located primarily in the western US. In addition, the report includes a sensitivity analysis of various factors which significantly effect the overall cost of the three systems. These analyses were based on a generic disposal site. Four different 3m thick earthen covers were tested and cost an average of $27/m 2 . The least expensive earthen cover cost was about $21/m 2 . The asphalt cover system (6 to 7 cm of asphalt topped with 0.6m of overburden) cost about $28/m 2 . The four multilayer covers averaged $57/m 2 , but materials handling problems encountered during the test inflated this cost above what was anticipated and significant cost reductions should be possible. The least expensive multilayer cover cost $43/m 2 . Based on the results of the Grand Junction field test we estimated the cost of covering the tailings from three high priority sites, Durango, Shiprock, and Salt Lake City (Vitro). The cost of a 3m earthen cover ranged from $18 to 33/m 2 for the seven disposal sites (two or three at each location) studied. The cost of asphalt cover systems were $23 to 28/m 2 and the multilayer cover costs were between $31 to 36/m 2 . The earthen cover costs are less than the Grand Junction field test cost primarily because cover material is available at or near most of the disposal sites selected. Earthen material was imported from 6 to 10 miles for the field test. Assuming more efficienct utilization of materials significantly reduced the cost of the multilayer covers

  19. Low temperature monitoring system for subsurface barriers

    Science.gov (United States)

    Vinegar, Harold J [Bellaire, TX; McKinzie, II Billy John [Houston, TX

    2009-08-18

    A system for monitoring temperature of a subsurface low temperature zone is described. The system includes a plurality of freeze wells configured to form the low temperature zone, one or more lasers, and a fiber optic cable coupled to at least one laser. A portion of the fiber optic cable is positioned in at least one freeze well. At least one laser is configured to transmit light pulses into a first end of the fiber optic cable. An analyzer is coupled to the fiber optic cable. The analyzer is configured to receive return signals from the light pulses.

  20. Engineered Barrier System: Physical and Chemical Environment Model

    International Nuclear Information System (INIS)

    Jolley, D. M.; Jarek, R.; Mariner, P.

    2004-01-01

    The conceptual and predictive models documented in this Engineered Barrier System: Physical and Chemical Environment Model report describe the evolution of the physical and chemical conditions within the waste emplacement drifts of the repository. The modeling approaches and model output data will be used in the total system performance assessment (TSPA-LA) to assess the performance of the engineered barrier system and the waste form. These models evaluate the range of potential water compositions within the emplacement drifts, resulting from the interaction of introduced materials and minerals in dust with water seeping into the drifts and with aqueous solutions forming by deliquescence of dust (as influenced by atmospheric conditions), and from thermal-hydrological-chemical (THC) processes in the drift. These models also consider the uncertainty and variability in water chemistry inside the drift and the compositions of introduced materials within the drift. This report develops and documents a set of process- and abstraction-level models that constitute the engineered barrier system: physical and chemical environment model. Where possible, these models use information directly from other process model reports as input, which promotes integration among process models used for total system performance assessment. Specific tasks and activities of modeling the physical and chemical environment are included in the technical work plan ''Technical Work Plan for: In-Drift Geochemistry Modeling'' (BSC 2004 [DIRS 166519]). As described in the technical work plan, the development of this report is coordinated with the development of other engineered barrier system analysis model reports

  1. Engineered Barrier System Thermal-Hydraulic-Chemical Column Test Report

    International Nuclear Information System (INIS)

    W.E. Lowry

    2001-01-01

    The Engineered Barrier System (EBS) Thermal-Hydraulic-Chemical (THC) Column Tests provide data needed for model validation. The EBS Degradation, Flow, and Transport Process Modeling Report (PMR) will be based on supporting models for in-drift THC coupled processes, and the in-drift physical and chemical environment. These models describe the complex chemical interaction of EBS materials, including granular materials, with the thermal and hydrologic conditions that will be present in the repository emplacement drifts. Of particular interest are the coupled processes that result in mineral and salt dissolution/precipitation in the EBS environment. Test data are needed for thermal, hydrologic, and geochemical model validation and to support selection of introduced materials (CRWMS M and O 1999c). These column tests evaluated granular crushed tuff as potential invert ballast or backfill material, under accelerated thermal and hydrologic environments. The objectives of the THC column testing are to: (1) Characterize THC coupled processes that could affect performance of EBS components, particularly the magnitude of permeability reduction (increases or decreases), the nature of minerals produced, and chemical fractionation (i.e., concentrative separation of salts and minerals due to boiling-point elevation). (2) Generate data for validating THC predictive models that will support the EBS Degradation, Flow, and Transport PMR, Rev. 01

  2. Natural and sexual selection giveth and taketh away reproductive barriers: models of population divergence in guppies.

    Science.gov (United States)

    Labonne, Jacques; Hendry, Andrew P

    2010-07-01

    The standard predictions of ecological speciation might be nuanced by the interaction between natural and sexual selection. We investigated this hypothesis with an individual-based model tailored to the biology of guppies (Poecilia reticulata). We specifically modeled the situation where a high-predation population below a waterfall colonizes a low-predation population above a waterfall. Focusing on the evolution of male color, we confirm that divergent selection causes the appreciable evolution of male color within 20 generations. The rate and magnitude of this divergence were reduced when dispersal rates were high and when female choice did not differ between environments. Adaptive divergence was always coupled to the evolution of two reproductive barriers: viability selection against immigrants and hybrids. Different types of sexual selection, however, led to contrasting results for another potential reproductive barrier: mating success of immigrants. In some cases, the effects of natural and sexual selection offset each other, leading to no overall reproductive isolation despite strong adaptive divergence. Sexual selection acting through female choice can thus strongly modify the effects of divergent natural selection and thereby alter the standard predictions of ecological speciation. We also found that under no circumstances did divergent selection cause appreciable divergence in neutral genetic markers.

  3. Improvements in or relating to thermal barrier systems

    International Nuclear Information System (INIS)

    Birch, W.; Pearson, R.

    1976-01-01

    Reference is made to thermal barrier systems for the internal surface of gas cooled reactor prestressed concrete pressure vessels. Provision has to be made to anchor the thermal barrier system to a metal limit within the pressure vessel, and the object of the arrangement described is to provided a suitable attachment means. The thermal barrier may consist of a number of plates arranged in overlapped fashion or having flexible joint portions. A problem that arises concerns anchoring of the hot plates to the cold pressure vessel by a rigid attachment, and the design must be such as to ensure adequate bending and axial strength compatible with a minimum heat conduction area and allowable thermal stress. The arrangement must also allow easy installation. The arrangement described also provides for a 'fail-safe' structure. It comprises a metal stud with a hollow body; two or more helical channels are provided through the side walls of the body. The body portion expands or contracts to accommodate axial temperature gradient stress set up by the temperature difference between the pressure vessel and the thermal barrier. The space between the thermal barrier and the pressure vessel may contain solid insulating material. (U.K.)

  4. Production Systems and Supplier Selection

    DEFF Research Database (Denmark)

    Pedraza-Acosta, Isabel; Pilkington, Alan; Barnes, David

    2016-01-01

    strategic stamping suppliers. Findings: Our contribution is the multi-phased production and product innovation process. This is an advance from traditional supplier selection and also an extension of ideas of supplier-located product development as it includes production system development, and complements...

  5. Engineered barrier experiment. Power control and data acquisition systems

    International Nuclear Information System (INIS)

    Alberdi, J.; Barcala, J.M.; Gamero, E.; Martin, P.L.; Molinero, A.; Navarrete, J.J.; Yuste, C.

    1997-01-01

    The engineered barrier concept for the storage of radioactive wastes is being tested at almost full scale at CIEMAT facilities. A data acquisition and control is an element of this experiment. This system would be operating for next three years. (Author)

  6. Alternative approaches to reliability modeling of a multiple engineered barrier system

    International Nuclear Information System (INIS)

    Ananda, M.M.A.; Singh, A.K.

    1994-01-01

    The lifetime of the engineered barrier system used for containment of high-level radioactive waste will significantly impact the total performance of a geological repository facility. Currently two types of designs are under consideration for an engineered barrier system, single engineered barrier system and multiple engineered barrier system. Multiple engineered barrier system consists of several metal barriers and the waste form (cladding). Some recent work show that a significant improvement of performance can be achieved by utilizing multiple engineered barrier systems. Considering sequential failures for each barrier, we model the reliability of the multiple engineered barrier system. Weibull and exponential lifetime distributions are used through out the analysis. Furthermore, the number of failed engineered barrier systems in a repository at a given time is modeled using a poisson approximation

  7. Field testing of asphalt-emulsion radon-barrier system

    International Nuclear Information System (INIS)

    Hartley, J.N.; Freeman, H.D.; Baker, E.G.; Elmore, M.R.; Nelson, D.A.; Voss, C.F.; Koehmstedt, P.L.

    1981-09-01

    Three years of laboratory and field testing have demonstrated that asphalt emulsion seals are effective radon diffusion barriers. Both laboratory and field tests in 1979, 1980 and 1981 have shown that an asphalt emulsion seal can reduce radon fluxes by greater than 99.9%. The effective diffusion coefficient for the various asphalt emulsion admix seals averages about 10 -6 cm 2 /s. The 1981 joint field test is a culmination of all the technology developed to date for asphalt emulsion radon barrier systems. Preliminary results of this field test and the results of the 1980 field test are presented. 18 figures, 6 tables

  8. ENGINEERED BARRIER SYSTEM FEATURES, EVENTS, AND PROCESSES

    International Nuclear Information System (INIS)

    2005-01-01

    This analysis report is one of the technical reports containing documentation of the Environmental Radiation Model for Yucca Mountain, Nevada (ERMYN), a biosphere model supporting the total system performance assessment (TSPA) for the license application (LA) for the Yucca Mountain repository. This analysis report describes the development of biosphere dose conversion factors (BDCFs) for the volcanic ash exposure scenario, and the development of dose factors for calculating inhalation dose during volcanic eruption. A graphical representation of the documentation hierarchy for the ERMYN is presented in Figure 1 - 1. This figure shows the interrelationships among the products (i.e., analysis and model reports) developed for biosphere modeling and provides an understanding of how this analysis report contributes to biosphere modeling. This report is one of two reports that develop biosphere BDCFs, which are input parameters for the TSPA model. The ''Biosphere Model Report'' (BSC 2004 [DIRS 169460]) describes in detail the ERMYN conceptual model and mathematical model. The input parameter reports, shown to the right of the Biosphere Model Report in Figure 1-1, contain detailed descriptions of the model input parameters, their development and the relationship between the parameters and specific features, events and processes (FEPs). This report describes biosphere model calculations and their output, the BDCFs, for the volcanic ash exposure scenario. This analysis receives direct input from the outputs of the ''Biosphere Model Report'' (BSC 2004 [DIRS 169460]) and from the five analyses that develop parameter values for the biosphere model (BSC 2005 [DIRS 172827]; BSC 2004 [DIRS 169672]; BSC 2004 [DIRS 169673]; BSC 2004 [DIRS 169458]; and BSC 2004 [DIRS 169459]). The results of this report are further analyzed in the ''Biosphere Dose Conversion Factor Importance and Sensitivity Analysis'' (Figure 1 - 1). The objective of this analysis was to develop the BDCFs for the

  9. Load management for refrigeration systems: Potentials and barriers

    Energy Technology Data Exchange (ETDEWEB)

    Grein, Arne, E-mail: a.grein@tu-berlin.de [University of Technology Berlin, Institute for Energy Technology, Department of Energy Systems, Einsteinufer 25 (TA8), 10587 Berlin (Germany); Pehnt, Martin [Institute for Energy and Environmental Research Heidelberg (ifeu), Wilckensstr. 3, 69120 Heidelberg (Germany)

    2011-09-15

    As a strategy to deal with the increasing intermittent input of renewable energy sources in Germany, the adaptation of power consumption is complementary to power-plant regulation, grid expansion and physical energy storage. One demand sector that promises strong returns for load management efforts is cooling and refrigeration. In these processes, thermal inertia provides a temporal buffer for shifting and adjusting the power consumption of cooling systems. We have conducted an empirical investigation to obtain a detailed and time-resolved bottom-up analysis of load management for refrigeration systems in the city of Mannheim, Germany. We have extrapolated our results to general conditions in Germany. Several barriers inhibit the rapid adoption of load management strategies for cooling systems, including informational barriers, strict compliance with legal cooling requirements, liability issues, lack of technical experience, an inadequate rate of return and organizational barriers. Small commercial applications of refrigeration in the food-retailing and cold storage in hotels and restaurants are particularly promising starting points for intelligent load management. When our results are applied to Germany, suitable sectors for load management have theoretical and achievable potential values of 4.2 and 2.8 GW, respectively, amounting to about 4-6% of the maximum power demand in Germany. - Highlights: > Potential and barriers for implementation of load shifting for refrigeration. > Empirical investigation for time-resolved bottom-up analysis in Mannheim, Germany. > Suitable sectors and further recommendations for introducing load management.> Extrapolation of results from local to national level.

  10. ENGINEERED BARRIER SYSTEM FEATURES, EVENTS, AND PROCESSES

    Energy Technology Data Exchange (ETDEWEB)

    na

    2005-05-30

    This analysis report is one of the technical reports containing documentation of the Environmental Radiation Model for Yucca Mountain, Nevada (ERMYN), a biosphere model supporting the total system performance assessment (TSPA) for the license application (LA) for the Yucca Mountain repository. This analysis report describes the development of biosphere dose conversion factors (BDCFs) for the volcanic ash exposure scenario, and the development of dose factors for calculating inhalation dose during volcanic eruption. A graphical representation of the documentation hierarchy for the ERMYN is presented in Figure 1 - 1. This figure shows the interrelationships among the products (i.e., analysis and model reports) developed for biosphere modeling and provides an understanding of how this analysis report contributes to biosphere modeling. This report is one of two reports that develop biosphere BDCFs, which are input parameters for the TSPA model. The ''Biosphere Model Report'' (BSC 2004 [DIRS 169460]) describes in detail the ERMYN conceptual model and mathematical model. The input parameter reports, shown to the right of the Biosphere Model Report in Figure 1-1, contain detailed descriptions of the model input parameters, their development and the relationship between the parameters and specific features, events and processes (FEPs). This report describes biosphere model calculations and their output, the BDCFs, for the volcanic ash exposure scenario. This analysis receives direct input from the outputs of the ''Biosphere Model Report'' (BSC 2004 [DIRS 169460]) and from the five analyses that develop parameter values for the biosphere model (BSC 2005 [DIRS 172827]; BSC 2004 [DIRS 169672]; BSC 2004 [DIRS 169673]; BSC 2004 [DIRS 169458]; and BSC 2004 [DIRS 169459]). The results of this report are further analyzed in the ''Biosphere Dose Conversion Factor Importance and Sensitivity Analysis'' (Figure 1 - 1). The

  11. Down-regulation of selected Blood-brain Barrier Specific Genes from Capillaries to Bovine In Vitro Models

    DEFF Research Database (Denmark)

    Goldeman, Charlotte; Saaby, Lasse; Brodin, Birger

    Cultures of primary bovine brain endothelial cells (BECs) grown, often together with astrocytes, on permeable supports in two-compartment culture systems are commonly used as an in vitro model of the blood-brain barrier (BBB). While trans-endothelial electrical resistance, restriction...... the in vivo gene expression of brain capillary endothelial cells. Primary bovine endothelial cells and rat astrocytes were cultured in different culture configurations and the mRNA expression of selected genes (vWF, Glut-1, P-gp, claudin-1,-5, occludin, JAM-1, LAT-1, SLC16A1, MRP-1,-4, BCRP, ZO-1, AP, TPA...

  12. DTR, Taut Wire System: An alarm barrier with experience

    International Nuclear Information System (INIS)

    Kraft, A.J.

    1986-01-01

    The Taut Wire Fence Alarm System concept was developed and introduced more that fifteen years ago in Israel. A sudden expansion of the nations's border lines, the difficulty to monitor intrusions along those elongated lines and the need for timely as well as accurate armed response to an intrusion attempt dictated the need for an alarming barrier. Traditionally, protection of perimeters was accomplished by the installation of a fence or other type obstacles (man made or natural) and surveillance by manned patrols, fixed observation posts, and/or electronic devices. Defense planners recognized therefore the need for an alarming barrier. A concentrated effort by scientists solved the problem by developing the first Taut Wire Fence Alarm System in a configuration of an alarm barrier. The system was specified to have an extremely low false alarm rate (FAR/NAR), high probability of detection, the capability to follow various terrains, operability in a wide range of environmental conditions, a capability to delay an intruder, ease of installation by unskilled labor, and low maintenance requirements. The authors try here to explain the various constraints and considerations given during the design stages of the Taut Wire Alarm System so as to bring the present magnitude of users to a better understanding of the system's operation

  13. Engineered Barrier System: Physical and Chemical Environment Model

    Energy Technology Data Exchange (ETDEWEB)

    D. M. Jolley; R. Jarek; P. Mariner

    2004-02-09

    The conceptual and predictive models documented in this Engineered Barrier System: Physical and Chemical Environment Model report describe the evolution of the physical and chemical conditions within the waste emplacement drifts of the repository. The modeling approaches and model output data will be used in the total system performance assessment (TSPA-LA) to assess the performance of the engineered barrier system and the waste form. These models evaluate the range of potential water compositions within the emplacement drifts, resulting from the interaction of introduced materials and minerals in dust with water seeping into the drifts and with aqueous solutions forming by deliquescence of dust (as influenced by atmospheric conditions), and from thermal-hydrological-chemical (THC) processes in the drift. These models also consider the uncertainty and variability in water chemistry inside the drift and the compositions of introduced materials within the drift. This report develops and documents a set of process- and abstraction-level models that constitute the engineered barrier system: physical and chemical environment model. Where possible, these models use information directly from other process model reports as input, which promotes integration among process models used for total system performance assessment. Specific tasks and activities of modeling the physical and chemical environment are included in the technical work plan ''Technical Work Plan for: In-Drift Geochemistry Modeling'' (BSC 2004 [DIRS 166519]). As described in the technical work plan, the development of this report is coordinated with the development of other engineered barrier system analysis model reports.

  14. Emergent Behavior of Coupled Barrier Island - Resort Systems

    Science.gov (United States)

    McNamara, D. E.; Werner, B. T.

    2004-12-01

    Barrier islands are attractive sites for resorts. Natural barrier islands experience beach erosion and island overwash during storms, beach accretion and dune building during inter-storm periods, and migration up the continental shelf as sea level rises. Beach replenishment, artificial dune building, seawalls, jetties and groins have been somewhat effective in protecting resorts against erosion and overwash during storms, but it is unknown how the coupled system will respond to long-term sea level rise. We investigate coupled barrier island - resort systems using an agent-based model with three components: natural barrier islands divided into a series of alongshore cells; resorts controlled by markets for tourism and hotel purchases; and coupling via storm damage to resorts and resort protection by government agents. Modeled barrier islands change by beach erosion, island overwash and inlet cutting during storms, and beach accretion, tidal delta growth and dune and vegetation growth between storms. In the resort hotel market, developer agents build hotels and hotel owning agents purchase them using predictions of future revenue and property appreciation, with the goal of maximizing discounted utility. In the tourism market, hotel owning agents set room rental prices to maximize profit and tourist agents choose vacation destinations maximizing a utility based on beach width, price and word-of-mouth. Government agents build seawalls, groins and jetties, and widen the beach and build up dunes by adding sand to protect resorts from storms, enhance beach quality, and maximize resort revenue. Results indicate that barrier islands and resorts evolve in a coupled manner to resort size saturation, with resorts protected against small-to-intermediate-scale storms under fairly stable sea level. Under extended, rapidly rising sea level, protection measures enhance the effect of large storms, leading to emergent behavior in the form of limit cycles or barrier submergence

  15. Prediction of Placental Barrier Permeability: A Model Based on Partial Least Squares Variable Selection Procedure

    Directory of Open Access Journals (Sweden)

    Yong-Hong Zhang

    2015-05-01

    Full Text Available Assessing the human placental barrier permeability of drugs is very important to guarantee drug safety during pregnancy. Quantitative structure–activity relationship (QSAR method was used as an effective assessing tool for the placental transfer study of drugs, while in vitro human placental perfusion is the most widely used method. In this study, the partial least squares (PLS variable selection and modeling procedure was used to pick out optimal descriptors from a pool of 620 descriptors of 65 compounds and to simultaneously develop a QSAR model between the descriptors and the placental barrier permeability expressed by the clearance indices (CI. The model was subjected to internal validation by cross-validation and y-randomization and to external validation by predicting CI values of 19 compounds. It was shown that the model developed is robust and has a good predictive potential (r2 = 0.9064, RMSE = 0.09, q2 = 0.7323, rp2 = 0.7656, RMSP = 0.14. The mechanistic interpretation of the final model was given by the high variable importance in projection values of descriptors. Using PLS procedure, we can rapidly and effectively select optimal descriptors and thus construct a model with good stability and predictability. This analysis can provide an effective tool for the high-throughput screening of the placental barrier permeability of drugs.

  16. Experimental Approach of Fault Movement on an Engineered Barrier System

    International Nuclear Information System (INIS)

    Lee, Minsoo; Choi, Heuijoo; Kim, Heuna

    2012-01-01

    Safety evaluation of an engineered barrier system against fault movement at underground disposal region for high level waste (HLW) is tried using a miniature bore-shear apparatus. For the purpose, a miniature bore-shear apparatus simulating an EBS (engineered barrier system) was manufactured in 1/30 scale. And using the developed apparatus, bore-shear tests were performed twice. During the tests, pressure variations were checked at 6 points around buffer zone, and then a rotational angle of the test vessel was checked. The achieved pressure data were compared with those from analytical modeling, which is based on Drucker-Prager model. At initial shearing step, high pressure was recorded at some point but it decreased rapidly. For the better understanding of fault movement, the modification of an analytical model and the accumulation of experimental experience were required

  17. Experimental Approach of Fault Movement on an Engineered Barrier System

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Minsoo; Choi, Heuijoo; Kim, Heuna [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2012-03-15

    Safety evaluation of an engineered barrier system against fault movement at underground disposal region for high level waste (HLW) is tried using a miniature bore-shear apparatus. For the purpose, a miniature bore-shear apparatus simulating an EBS (engineered barrier system) was manufactured in 1/30 scale. And using the developed apparatus, bore-shear tests were performed twice. During the tests, pressure variations were checked at 6 points around buffer zone, and then a rotational angle of the test vessel was checked. The achieved pressure data were compared with those from analytical modeling, which is based on Drucker-Prager model. At initial shearing step, high pressure was recorded at some point but it decreased rapidly. For the better understanding of fault movement, the modification of an analytical model and the accumulation of experimental experience were required.

  18. Yucca Mountain engineered barrier system corrosion model (EBSCOM)

    International Nuclear Information System (INIS)

    King, F.; Kolar, M.; Kessler, J.H.; Apted, M.

    2008-01-01

    A revised engineered barrier system model has been developed by the Electric Power Research Institute to predict the time dependence of the failure of the drip shields and waste packages in the proposed Yucca Mountain repository. The revised model is based on new information on various corrosion processes developed by the US Department of Energy and others and for a 20-mm-thick waste package design with a double closure lid system. As with earlier versions of the corrosion model, the new EBSCOM code produces a best-estimate of the failure times of the various barriers. The model predicts that only 15% of waste packages will fail within a period of 1 million years. The times for the first corrosion failures are 40,000 years, 336,000 years, and 375,000 years for the drip shield, waste package, and combination of drip shield and the associated waste package, respectively

  19. Integrated modelling of near field and engineered barrier system processes

    International Nuclear Information System (INIS)

    Lamont, A.; Gansemer, J.

    1994-01-01

    The Yucca Mountain Integrating Model (YMIM) is an integrated model of the Engineered barrier System has been developed to assist project managers at LLNL in identifying areas where research emphasis should be placed. The model was designed to be highly modular so that a model of an individual process could be easily modified or replaced without interfering with the models of other processes. The modules modelling container failure and the dissolution of nuclides include particularly detailed, temperature dependent models of their corresponding processes

  20. Selection of design parameters of diffusion barrier in a passive 222Rn sampler based on activated charcoal adsorption

    International Nuclear Information System (INIS)

    Wei Suxia

    1992-01-01

    A method concerning selection of design parameters of diffusion barrier in a passive 222 Rn sampler based on activated charcoal adsorption. The proper parameter value of diffusion barrier is obtained by means of linearization of 222 Rn adsorption versus the exposure time. Thus, the influence of temperature on measured results may be greatly decreased, and higher sensitivity of the detector may be maintained

  1. Load management for refrigeration systems: Potentials and barriers

    International Nuclear Information System (INIS)

    Grein, Arne; Pehnt, Martin

    2011-01-01

    As a strategy to deal with the increasing intermittent input of renewable energy sources in Germany, the adaptation of power consumption is complementary to power-plant regulation, grid expansion and physical energy storage. One demand sector that promises strong returns for load management efforts is cooling and refrigeration. In these processes, thermal inertia provides a temporal buffer for shifting and adjusting the power consumption of cooling systems. We have conducted an empirical investigation to obtain a detailed and time-resolved bottom-up analysis of load management for refrigeration systems in the city of Mannheim, Germany. We have extrapolated our results to general conditions in Germany. Several barriers inhibit the rapid adoption of load management strategies for cooling systems, including informational barriers, strict compliance with legal cooling requirements, liability issues, lack of technical experience, an inadequate rate of return and organizational barriers. Small commercial applications of refrigeration in the food-retailing and cold storage in hotels and restaurants are particularly promising starting points for intelligent load management. When our results are applied to Germany, suitable sectors for load management have theoretical and achievable potential values of 4.2 and 2.8 GW, respectively, amounting to about 4-6% of the maximum power demand in Germany. - Highlights: → Potential and barriers for implementation of load shifting for refrigeration. → Empirical investigation for time-resolved bottom-up analysis in Mannheim, Germany. → Suitable sectors and further recommendations for introducing load management.→ Extrapolation of results from local to national level.

  2. Computational design and experimental validation of new thermal barrier systems

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shengmin [Louisiana State Univ., Baton Rouge, LA (United States)

    2015-03-31

    The focus of this project is on the development of a reliable and efficient ab initio based computational high temperature material design method which can be used to assist the Thermal Barrier Coating (TBC) bond-coat and top-coat design. Experimental evaluations on the new TBCs are conducted to confirm the new TBCs’ properties. Southern University is the subcontractor on this project with a focus on the computational simulation method development. We have performed ab initio density functional theory (DFT) method and molecular dynamics simulation on screening the top coats and bond coats for gas turbine thermal barrier coating design and validation applications. For experimental validations, our focus is on the hot corrosion performance of different TBC systems. For example, for one of the top coatings studied, we examined the thermal stability of TaZr2.75O8 and confirmed it’s hot corrosion performance.

  3. Origin of Small Barriers in Jahn–Teller Systems

    DEFF Research Database (Denmark)

    Barriuso, M. T.; Ortiz-Sevilla, B.; Aramburu, J. A.

    2013-01-01

    . It is quantitatively proven that the elongated geometry observed for NaCl:Ni+ is due to the 3d–4s vibronic admixture, which is slightly larger than the anharmonicity in the eg JT mode that favors a compressed geometry. The existence of these two competing mechanisms explains the low value of B for the model system......Despite its relevance, the microscopic origin of the energy barrier, B, between the compressed and elongated geometries of Jahn–Teller (JT) systems is not well understood yet because of a lack of quantitative data about its various contributions. Seeking to clear up this matter, we have carried out...

  4. Case history: Vertical barrier wall system for Superfund Site

    International Nuclear Information System (INIS)

    Koelling, M.A.; Kovac, C.P.; Norris, J.E.

    1997-01-01

    Design considerations and construction aspects are presented for the installation of a vertical barrier wall system for the Boeing Company at a Superfund Site near Seattle, WA. The construction was performed during 1996. The vertical barrier wall system included: (1) a soil-bentonite (SB) slurry wall, approximately 670 meters (2200 feet) in length, ranging from 12 to 21 meters (40 to 70 feet) in depth; (2) expansion of a cover system over the area enclosed by the SB wall; and (3) surface drainage improvements. Design and construction of the system addressed requirements of a Consent Decree for the site issued in 1993. The paper discusses the development of the design to meet remedial performance goals of preventing migration of contaminants in the soil/groundwater system and aiding aquifer restoration. Secondly, the paper details installation of the SB wall, highlighting the more significant construction issues, which included excavation of the wall through glacially deposited cobbles/boulders/till as well as addressing the severe elevation changes along the wall alignment. Thirdly, the paper presents Quality Assurance (QA) monitoring and testing performed during the construction phase

  5. Thermophysical and Thermomechanical Properties of Thermal Barrier Coating Systems

    Science.gov (United States)

    Zhu, Dongming; Miller, Robert A.

    2000-01-01

    Thermal barrier coatings have been developed for advanced gas turbine and diesel engine applications to improve engine reliability and fuel efficiency. However, the issue of coating durability under high temperature cyclic conditions is still of major concern. The coating failure is closely related to thermal stresses and oxidation in the coating systems. Coating shrinkage cracking resulting from ceramic sintering and creep at high temperatures can further accelerate the coating failure process. The purpose of this paper is to address critical issues such as ceramic sintering and creep, thermal fatigue and their relevance to coating life prediction. Novel test approaches have been established to obtain critical thermophysical and thermomechanical properties of the coating systems under near-realistic temperature and stress gradients encountered in advanced engine systems. Emphasis is placed on the dynamic changes of the coating thermal conductivity and elastic modulus, fatigue and creep interactions, and resulting failure mechanisms during the simulated engine tests. Detailed experimental and modeling results describing processes occurring in the thermal barrier coating systems provide a framework for developing strategies to manage ceramic coating architecture, microstructure and properties.

  6. Magnet system for a thermal barrier Tandem Mirror Reactor

    International Nuclear Information System (INIS)

    Kim, N.S.; Conn, R.W.

    1981-01-01

    The magnet system for a thermal barrier D-D tandem mirror reactor has been studied as part of the UCLA tandem mirror reactor design study SATYR. Three main considerations in designing the SATYR magnet system are to obtain the desired field strength variation throughout the system, to have proper space for plasma and neutron shielding, and to satisfy the MHD stability to achieve maximum central cell /beta/. Due to the importance and the complexity, the 'internal' field reversal magnet is the main concern in the entire magnet system for SATYR. Two different magnet designs, a non-uniform current density solenoid and a higher-order solenoid, are discussed. Coil levitation for the internal field reversal magnet has been analyzed

  7. Towards a barrier height benchmark set for biologically relevant systems.

    Science.gov (United States)

    Kromann, Jimmy C; Christensen, Anders S; Cui, Qiang; Jensen, Jan H

    2016-01-01

    We have collected computed barrier heights and reaction energies (and associated model structures) for five enzymes from studies published by Himo and co-workers. Using this data, obtained at the B3LYP/6- 311+G(2d,2p)[LANL2DZ]//B3LYP/6-31G(d,p) level of theory, we then benchmark PM6, PM7, PM7-TS, and DFTB3 and discuss the influence of system size, bulk solvation, and geometry re-optimization on the error. The mean absolute differences (MADs) observed for these five enzyme model systems are similar to those observed for PM6 and PM7 for smaller systems (10-15 kcal/mol), while DFTB results in a MAD that is significantly lower (6 kcal/mol). The MADs for PMx and DFTB3 are each dominated by large errors for a single system and if the system is disregarded the MADs fall to 4-5 kcal/mol. Overall, results for the condensed phase are neither more or less accurate relative to B3LYP than those in the gas phase. With the exception of PM7-TS, the MAD for small and large structural models are very similar, with a maximum deviation of 3 kcal/mol for PM6. Geometry optimization with PM6 shows that for one system this method predicts a different mechanism compared to B3LYP/6-31G(d,p). For the remaining systems, geometry optimization of the large structural model increases the MAD relative to single points, by 2.5 and 1.8 kcal/mol for barriers and reaction energies. For the small structural model, the corresponding MADs decrease by 0.4 and 1.2 kcal/mol, respectively. However, despite these small changes, significant changes in the structures are observed for some systems, such as proton transfer and hydrogen bonding rearrangements. The paper represents the first step in the process of creating a benchmark set of barriers computed for systems that are relatively large and representative of enzymatic reactions, a considerable challenge for any one research group but possible through a concerted effort by the community. We end by outlining steps needed to expand and improve the data set

  8. Towards a barrier height benchmark set for biologically relevant systems

    Directory of Open Access Journals (Sweden)

    Jimmy C. Kromann

    2016-05-01

    Full Text Available We have collected computed barrier heights and reaction energies (and associated model structures for five enzymes from studies published by Himo and co-workers. Using this data, obtained at the B3LYP/6- 311+G(2d,2p[LANL2DZ]//B3LYP/6-31G(d,p level of theory, we then benchmark PM6, PM7, PM7-TS, and DFTB3 and discuss the influence of system size, bulk solvation, and geometry re-optimization on the error. The mean absolute differences (MADs observed for these five enzyme model systems are similar to those observed for PM6 and PM7 for smaller systems (10–15 kcal/mol, while DFTB results in a MAD that is significantly lower (6 kcal/mol. The MADs for PMx and DFTB3 are each dominated by large errors for a single system and if the system is disregarded the MADs fall to 4–5 kcal/mol. Overall, results for the condensed phase are neither more or less accurate relative to B3LYP than those in the gas phase. With the exception of PM7-TS, the MAD for small and large structural models are very similar, with a maximum deviation of 3 kcal/mol for PM6. Geometry optimization with PM6 shows that for one system this method predicts a different mechanism compared to B3LYP/6-31G(d,p. For the remaining systems, geometry optimization of the large structural model increases the MAD relative to single points, by 2.5 and 1.8 kcal/mol for barriers and reaction energies. For the small structural model, the corresponding MADs decrease by 0.4 and 1.2 kcal/mol, respectively. However, despite these small changes, significant changes in the structures are observed for some systems, such as proton transfer and hydrogen bonding rearrangements. The paper represents the first step in the process of creating a benchmark set of barriers computed for systems that are relatively large and representative of enzymatic reactions, a considerable challenge for any one research group but possible through a concerted effort by the community. We end by outlining steps needed to expand and

  9. Sub-barrier fusion of Si+Si systems

    Science.gov (United States)

    Colucci, G.; Montagnoli, G.; Stefanini, A. M.; Bourgin, D.; Čolović, P.; Corradi, L.; Courtin, S.; Faggian, M.; Fioretto, E.; Galtarossa, F.; Goasduff, A.; Haas, F.; Mazzocco, M.; Scarlassara, F.; Stefanini, C.; Strano, E.; Urbani, M.; Szilner, S.; Zhang, G. L.

    2017-11-01

    The near- and sub-barrier fusion excitation function has been measured for the system 30Si+30Si at the Laboratori Nazionali di Legnaro of INFN, using the 30Si beam of the XTU Tandem accelerator in the energy range 47 - 90 MeV. A set-up based on a beam electrostatic deflector was used for detecting fusion evaporation residues. The measured cross sections have been compared to previous data on 28Si+28Si and Coupled Channels (CC) calculations have been performed using M3Y+repulsion and Woods-Saxon potentials, where the lowlying 2+ and 3- excitations have been included. A weak imaginary potential was found to be necessary to reproduce the low energy 28Si+28Si data. This probably simulates the effect of the oblate deformation of this nucleus. On the contrary, 30Si is a spherical nucleus, 30Si+30Si is nicely fit by CC calculations and no imaginary potential is needed. For this system, no maximum shows up for the astrophysical S-factor so that we have no evidence for hindrance, as confirmed by the comparison with CC calculations. The logarithmic derivative of the two symmetric systems highlights their different low energy trend. A difference can also be noted in the two barrier distributions, where the high-energy peak present in 28Si+28Si is not observed for 30Si+30Si, probably due to the weaker couplings in last case.

  10. Sub-barrier fusion of Si+Si systems

    Directory of Open Access Journals (Sweden)

    Colucci G.

    2017-01-01

    Full Text Available The near- and sub-barrier fusion excitation function has been measured for the system 30Si+30Si at the Laboratori Nazionali di Legnaro of INFN, using the 30Si beam of the XTU Tandem accelerator in the energy range 47 - 90 MeV. A set-up based on a beam electrostatic deflector was used for detecting fusion evaporation residues. The measured cross sections have been compared to previous data on 28Si+28Si and Coupled Channels (CC calculations have been performed using M3Y+repulsion and Woods-Saxon potentials, where the lowlying 2+ and 3− excitations have been included. A weak imaginary potential was found to be necessary to reproduce the low energy 28Si+28Si data. This probably simulates the effect of the oblate deformation of this nucleus. On the contrary, 30Si is a spherical nucleus, 30Si+30Si is nicely fit by CC calculations and no imaginary potential is needed. For this system, no maximum shows up for the astrophysical S-factor so that we have no evidence for hindrance, as confirmed by the comparison with CC calculations. The logarithmic derivative of the two symmetric systems highlights their different low energy trend. A difference can also be noted in the two barrier distributions, where the high-energy peak present in 28Si+28Si is not observed for 30Si+30Si, probably due to the weaker couplings in last case.

  11. Management-retrieval code system of fission barrier parameter sub-library

    International Nuclear Information System (INIS)

    Zhang Limin; Su Zongdi; Ge Zhigang

    1995-01-01

    The fission barrier parameter (FBP) library, which is a sub-library of Chinese Evaluated Nuclear Parameter library (CENPL), stores various popular used fission barrier parameters from different historical period, and could retrieve the required fission barrier parameters by using the management retrieval code system of the FBP sub-library. The function, feature and operation instruction of the code system are described briefly

  12. Selective tungsten deposition in a batch cold wall CVD system

    International Nuclear Information System (INIS)

    Chow, R.; Kang, S.; Harshbarger, W.R.; Susoeff, M.

    1987-01-01

    Selective deposition of tungsten offers many advantages for VLSI technology. The process can be used as a planarization technique for multilevel interconnect technology, it can be used to fill contacts and to provide a barrier layer between Al and Si materials, and the selective W process might be used as a self-aligned technology to provide low resistance layers on source/drain and gate conductors. Recent publications have indicate that cold wall CVD systems provide advantages for development of selective W process. Genus has investigated selective W deposition processing, and we have developed a selective W deposition process for the Genus 8402 multifilm deposition system. This paper describes the Genus 8402 system and the selective W process developed in this reactor. To further develop selective W technology, Genus has signed an agreement with General Electric establishing a joint development program. As a part of this program, the authors characterized the selective W process for encroachment, Si consumption and degrees of selectivity on various dielectrics. The status of this development activity and process characterization is reviewed in this paper

  13. Computational Design and Experimental Validation of New Thermal Barrier Systems

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shengmin; Yang, Shizhong; Khosravi, Ebrahim

    2011-12-31

    This project (10/01/2010-9/30/2013), “Computational Design and Experimental Validation of New Thermal Barrier Systems”, originates from Louisiana State University (LSU) Mechanical Engineering Department and Southern University (SU) Department of Computer Science. This proposal will directly support the technical goals specified in DE-FOA-0000248, Topic Area 3: Turbine Materials, by addressing key technologies needed to enable the development of advanced turbines and turbine-based systems that will operate safely and efficiently using coal-derived synthesis gases. We will develop novel molecular dynamics method to improve the efficiency of simulation on novel TBC materials; we will perform high performance computing (HPC) on complex TBC structures to screen the most promising TBC compositions; we will perform material characterizations and oxidation/corrosion tests; and we will demonstrate our new Thermal barrier coating (TBC) systems experimentally under Integrated gasification combined cycle (IGCC) environments. The durability of the coating will be examined using the proposed High Temperature/High Pressure Durability Test Rig under real syngas product compositions.

  14. Scientific investigation plan for initial engineered barrier system field tests

    International Nuclear Information System (INIS)

    Wunan Lin.

    1993-02-01

    The purpose of this Scientific Investigation Plan (SIP) is to describe tests known as Initial Engineered Barrier System Field Tests (IEBSFT) and identified by Work Breakdown Structure as WBS 1.2.2.2.4. The IEBSFT are precursors to the Engineered Barrier System Field Test (EBSFT), WBS 1.2.2.2.4, to be conducted in the Exploratory Study Facility (ESF) at Yucca Mountain. The EBSFT and IEBSFT are designed to provide information on the interaction between waste packages (simulated by heated containers) and the surrounding rock mass, its vadose water, and infiltrated water. Heater assemblies will be installed in drifts or boreholes openings and heated to measure moisture movement during heat-up and subsequent cool-down of the rock mass. In some of the tests, infiltration of water into the heated rock mass will be studied. Throughout the heating and cooling cycle, instruments installed in the rock will monitor such parameters as temperature, moisture content, concentration of some chemical species, and stress and strain. Rock permeability measurements, rock and fluid (water and gas) sampling, and fracture pattern measurements will also be made before and after the test

  15. Classification of paraglacial barrier systems: coastal New England, USA.

    NARCIS (Netherlands)

    FitzGerald, D.M.; van Heteren, S.

    1999-01-01

    The New England coast harbours a wide variety of barrier forms, which we organize into six barrier-coastline types. The barriers develop in response to the relative importance of several spatially and temporally variable parameters, particularly antecedent topography and geology, sediment abundance

  16. Development of backfill material as an engineered barrier in the waste package system. Interim topical report

    International Nuclear Information System (INIS)

    Wheelwright, E.J.; Hodges, F.N.; Bray, L.A.; Westsik, J.H. Jr.; Lester, D.H.; Nakai, T.L.; Spaeth, M.E.; Stula, R.T.

    1981-09-01

    A backfill barrier, emplaced between the containerized waste and the host rock, can both protect the other engineered barriers and act as a primary barrier to the release of radionuclides from the waste package. Attributes that a backfill should provide in order to carry out its required function have been identified. Primary attributes are those that have a direct effect upon the release and transport of radionuclides from the waste package. Supportive attributes do not directly affect radionuclide release but are necessary to support the primary attributes. The primary attributes, in order of importance, are: minimize (retard or exclude) the migration of ground water between the host rock and the waste canister system; retard the migration of selected chemical species (corrosive species and radionuclides) in the ground water; control the Eh and pH of the ground water within the waste-package environment. The supportive attributes are: self-seal any cracks or discontinuities in the backfill or interfacing host geology; retain performance properties at all repository temperatures; retain peformance properties during and after receiving repository levels of gamma radiation; conduct heat from the canister system to the host geology; retain mechanical properties and provide resistance to applied mechanical forces; retain morphological stability and compatibility with structural barriers and with the host geology for required period of time. Screening and selection of candidate backfill materials has resulted in a preliminary list of materials for testing. Primary emphasis has been placed on sodium and calcium bentonites and zeolites used in conjunction with quartz sand or crushed host rock. Preliminary laboratory studies have concentrated on permeability, sorption, swelling pressure, and compaction properties of candidate backfill materials

  17. A Selection Method for COTS Systems

    DEFF Research Database (Denmark)

    Hedman, Jonas

    new skills and methods supporting the process of evaluating and selecting information systems. This paper presents a method for selecting COTS systems. The method includes the following phases: problem framing, requirements and appraisal, and selection of systems. The idea and distinguishing feature...... behind the method is that improved understanding of organizational' ends' or goals should govern the selection of a COTS system. This can also be expressed as a match or fit between ‘ends' (e.g. improved organizational effectiveness) and ‘means' (e.g. implementing COTS systems). This way of approaching...

  18. Materials Selection for Aerospace Systems

    Science.gov (United States)

    Arnold, Steven M.; Cebon, David; Ashby, Mike

    2012-01-01

    A systematic design-oriented, five-step approach to material selection is described: 1) establishing design requirements, 2) material screening, 3) ranking, 4) researching specific candidates and 5) applying specific cultural constraints to the selection process. At the core of this approach is the definition performance indices (i.e., particular combinations of material properties that embody the performance of a given component) in conjunction with material property charts. These material selection charts, which plot one property against another, are introduced and shown to provide a powerful graphical environment wherein one can apply and analyze quantitative selection criteria, such as those captured in performance indices, and make trade-offs between conflicting objectives. Finding a material with a high value of these indices maximizes the performance of the component. Two specific examples pertaining to aerospace (engine blades and pressure vessels) are examined, both at room temperature and elevated temperature (where time-dependent effects are important) to demonstrate the methodology. The discussion then turns to engineered/hybrid materials and how these can be effectively tailored to fill in holes in the material property space, so as to enable innovation and increases in performance as compared to monolithic materials. Finally, a brief discussion is presented on managing the data needed for materials selection, including collection, analysis, deployment, and maintenance issues.

  19. Edge transport barrier formation in compact helical system

    International Nuclear Information System (INIS)

    Okamura, S; Minami, T; Oishi, T; Suzuki, C; Ida, K; Isobe, M; Yoshimura, Y; Nagaoka, K; Toi, K; Fujisawa, A; Akiyama, T; Iguchi, H; Ikeda, R; Kado, S; Matsuoka, K; Matsushita, H; Nakamura, K; Nakano, H; Nishimura, S; Nishiura, M; Ohshima, S; Shimizu, A; Takagi, S; Takahashi, C; Takeuchi, M; Yoshinuma, M

    2004-01-01

    The edge transport barrier (ETB) for particle transport is formed in the neutral beam (NB) heated hydrogen discharges in compact helical system (CHS). The transition to the ETB formation and the back transition are controlled by the heating power. The existence of the heating power threshold is confirmed and it is roughly proportional to the density. The Hα emission signal shows a clear drop at the transition (the timescale of signal decrease is ∼1 ms for the high heating power case). The ETB formation continues for the full duration of NB injection (100 ms) with a moderate level of radiation power loss. Local density profile measurement shows increase of the edge density and the movement of the density gradient region towards the edge

  20. PEBS. Long-term performance of engineered barrier systems

    Energy Technology Data Exchange (ETDEWEB)

    Wieczorek, Klaus; Czaikowski, Oliver; Miehe, Ruediger

    2014-12-15

    The evolution of the engineered barrier system (EBS) of geological repositories for radioactive waste has been the subject of many national and international research programmes. The emphasis of the research activities was on the elaboration of a detailed understanding of the complex THMC processes, which are expected to evolve in the early post closure period in the near field. From the perspective of radiological long-term safety, an in-depth understanding of these coupled processes is of great significance, because the evolution of the EBS during the early post-closure phase may have a non-negligible impact on the radiological safety functions at the time when the canisters breach. Unexpected process interactions during the resaturation phase could impair the safety-relevant parameters in the EBS (e. g. swelling pressure, hydraulic conductivity, diffusivity).

  1. Interpretation of quasi-elastic barrier distributions for weakly bound systems

    International Nuclear Information System (INIS)

    Monteiro, D.S.; Gomes, P.R.S.; Lubian, J.

    2009-01-01

    Full text: We verify that quasi-elastic (elastic + inelastic) backscattering barrier distributions for weakly bound systems do not strictly correspond to fusion barrier distributions, but rather to reaction threshold distribution, as proposed by Zagrebaev in a recent paper concerning very heavy systems. In this work, we investigate whether Zagrebaevs interpretation is valid by comparing experimental results obtained in two very recent works with the 6 Li + 144 Sm system. Monteiro et al derived the quasi-elastic barrier distribution (or reaction threshold distribution, following Zagrebaevs interpretation) by adding elastic and inelastic backscattering for this system. Rath et al obtained fusion barrier distribution for the same system from the measured complete fusion cross section for the same system. We conclude that the quasi-elastic barrier distributions can be associated with fusion barrier distributions only in situations where there are no relevant reaction channels apart from fusion. This is not the situation for very heavy nor for weakly bound systems. (author)

  2. Connectivity and systemic resilience of the Great Barrier Reef.

    Directory of Open Access Journals (Sweden)

    Karlo Hock

    2017-11-01

    Full Text Available Australia's iconic Great Barrier Reef (GBR continues to suffer from repeated impacts of cyclones, coral bleaching, and outbreaks of the coral-eating crown-of-thorns starfish (COTS, losing much of its coral cover in the process. This raises the question of the ecosystem's systemic resilience and its ability to rebound after large-scale population loss. Here, we reveal that around 100 reefs of the GBR, or around 3%, have the ideal properties to facilitate recovery of disturbed areas, thereby imparting a level of systemic resilience and aiding its continued recovery. These reefs (1 are highly connected by ocean currents to the wider reef network, (2 have a relatively low risk of exposure to disturbances so that they are likely to provide replenishment when other reefs are depleted, and (3 have an ability to promote recovery of desirable species but are unlikely to either experience or spread COTS outbreaks. The great replenishment potential of these 'robust source reefs', which may supply 47% of the ecosystem in a single dispersal event, emerges from the interaction between oceanographic conditions and geographic location, a process that is likely to be repeated in other reef systems. Such natural resilience of reef systems will become increasingly important as the frequency of disturbances accelerates under climate change.

  3. Failure mechanism for thermal fatigue of thermal barrier coating systems

    Energy Technology Data Exchange (ETDEWEB)

    Giolli, C.; Scrivani, A.; Rizzi, G. [Turbocoating S.p.A., Rubbiano di Solignano (Italy); Borgioli, F. [Firenze Univ., Sesto Fiorentino (Italy); Bolelli, G.; Lusvarghi, L. [Univ. di Modena e Reggio Emilia, Modena (Italy)

    2008-07-01

    High temperature thermal fatigue causes the failure of Thermal Barrier Coating (TBC) systems. Due to the difference in thickness and microstructure between thick TBCs and traditional thin TBCs, they cannot be assumed a-priori to possess the same failure mechanisms. Thick TBCs, consisting of a CoNiCrAlY bond coat and Yttria Partially Stabilised Zirconia top coat with different values of porosity, were produced by Air Plasma Spray. Thermal fatigue resistance limit of TBCs was tested by Furnace Cycling Tests (FCT) according to the specifications of an Original Equipment Manufacturer (OEM). TBC systems were analyzed before and after FCT. The morphological and chemical evolution of CoNiCrAlY/TGO microstructure was studied. Sintering effect, residual stress, phase transformation and fracture toughness were evaluated in the ceramic Top Coat. All the tested samples passed FCT according to the specification of an important OEM. Thermal fatigue resistance increases with the amount of porosity in the top coat. The compressive in-plane stresses increase in the TBC systems after thermal cycling, nevertheless the increasing rate has a trend contrary to the porosity level of top coat. The data suggest that the spallation happens at the TGO/Top Coat interface. The failure mechanism of thick TBCs subjected to thermal fatigue was eventually found to be similar to the failure mechanism of thin TBC systems made by APS. (orig.)

  4. Representing solute transport through the multi-barrier disposal system by simplified concepts

    International Nuclear Information System (INIS)

    Poteri, A.; Nordman, H.; Pulkkanen, V-M.; Kekaelaeinen, P.; Hautojaervi, A.

    2012-02-01

    The repository system chosen in Finland for spent nuclear fuel is composed of multiple successive transport barriers. If a waste canister is leaking, this multi-barrier system retards and limits the release rates of radionuclides into the biosphere. Analysis of radionuclide migration in the previous performance assessments has largely been based on numerical modelling of the repository system. The simplified analytical approach introduced here provides a tool to analyse the performance of the whole system using simplified representations of the individual transport barriers. This approach is based on the main characteristics of the individual barriers and on the generic nature of the coupling between successive barriers. In the case of underground repository the mass transfer between successive transport barriers is strongly restricted by the interfaces between barriers leading to well-mixed conditions in these barriers. The approach here simplifies the barrier system so that it can be described with a very simple compartment model, where each barrier is represented by a single, or in the case of buffer, by not more than two compartments. This system of compartments could be solved in analogy with a radioactive decay chain. The model of well mixed compartments lends itself to a very descriptive way to represent and analyse the barrier system because the relative efficiency of the different barriers in hindering transport of solutes can be parameterised by the solutes half-times in the corresponding compartments. In a real repository system there will also be a delay between the start of the inflow and the start of the outflow from the barrier. This delay can be important for the release rates of the short lived and sorbing radionuclides, and it was also included in the simplified representation of the barrier system. In a geological multi-barrier system, spreading of the outflowing release pulse is often governed by the typical behaviour of one transport barrier

  5. Representing solute transport through the multi-barrier disposal system by simplified concepts

    Energy Technology Data Exchange (ETDEWEB)

    Poteri, A.; Nordman, H.; Pulkkanen, V-M. [VTT Technical Research Centre of Finland, Espoo (Finland); Kekaelaeinen, P. [Jyvaeskylae Univ. (Finland). Dept. pf Physics; Hautojaervi, A.

    2012-02-15

    The repository system chosen in Finland for spent nuclear fuel is composed of multiple successive transport barriers. If a waste canister is leaking, this multi-barrier system retards and limits the release rates of radionuclides into the biosphere. Analysis of radionuclide migration in the previous performance assessments has largely been based on numerical modelling of the repository system. The simplified analytical approach introduced here provides a tool to analyse the performance of the whole system using simplified representations of the individual transport barriers. This approach is based on the main characteristics of the individual barriers and on the generic nature of the coupling between successive barriers. In the case of underground repository the mass transfer between successive transport barriers is strongly restricted by the interfaces between barriers leading to well-mixed conditions in these barriers. The approach here simplifies the barrier system so that it can be described with a very simple compartment model, where each barrier is represented by a single, or in the case of buffer, by not more than two compartments. This system of compartments could be solved in analogy with a radioactive decay chain. The model of well mixed compartments lends itself to a very descriptive way to represent and analyse the barrier system because the relative efficiency of the different barriers in hindering transport of solutes can be parameterised by the solutes half-times in the corresponding compartments. In a real repository system there will also be a delay between the start of the inflow and the start of the outflow from the barrier. This delay can be important for the release rates of the short lived and sorbing radionuclides, and it was also included in the simplified representation of the barrier system. In a geological multi-barrier system, spreading of the outflowing release pulse is often governed by the typical behaviour of one transport barrier

  6. Linear and non-linear energy barriers in systems of interacting single-domain ferromagnetic particles

    International Nuclear Information System (INIS)

    Petrila, Iulian; Bodale, Ilie; Rotarescu, Cristian; Stancu, Alexandru

    2011-01-01

    A comparative analysis between linear and non-linear energy barriers used for modeling statistical thermally-excited ferromagnetic systems is presented. The linear energy barrier is obtained by new symmetry considerations about the anisotropy energy and the link with the non-linear energy barrier is also presented. For a relevant analysis we compare the effects of linear and non-linear energy barriers implemented in two different models: Preisach-Neel and Ising-Metropolis. The differences between energy barriers which are reflected in different coercive field dependence of the temperature are also presented. -- Highlights: → The linear energy barrier is obtained from symmetry considerations. → The linear and non-linear energy barriers are calibrated and implemented in Preisach-Neel and Ising-Metropolis models. → The temperature and time effects of the linear and non-linear energy barriers are analyzed.

  7. [The blood-brain barrier and drug delivery in the central nervous system].

    Science.gov (United States)

    Loch-Neckel, Gecioni; Koepp, Janice

    2010-08-01

    To provide an updated view of the difficulties due to barriers and strategies used to allow the release of drugs in the central nervous system. The difficulty for the treatment of many diseases of the central nervous system, through the use of intra-venous drugs, is due to the presence of barriers that prevent the release of the same: the blood-brain barrier, blood-cerebro-spinal fluid barrier and the blood-arachnoid barrier. The blood-brain barrier is the main barrier for the transport of drugs in the brain that also acts as a immunologic and metabolic barrier. The endothelial cells of the blood-brain barrier are connected to a junction complex through the interaction of transmembrane proteins that protrude from de inside to the outside, forming a connection between the endothelial cells. The transport of substances to the brain depends on the mechanisms of transport present in the barrier and the diffusion of these compounds also depends on the physicochemical characteristics of the molecule. Some diseases alter the permeability of the blood-brain barrier and thus the passage of drugs. Strategies such as the use of methods for drug delivery in the brain have been investigated. Further details regarding the mechanisms of transport across the blood-brain barrier and the changes in neuropathology would provide important information about the etiology of diseases and lead to better therapeutic strategies.

  8. Selective effects of alpha-MSH and MIF-1 on the blood-brain barrier

    International Nuclear Information System (INIS)

    Sankar, R.; Domer, F.R.; Kastin, A.J.

    1981-01-01

    The effects of intravenously-injected alpha-MSH and MIF-1 (Pro-Leu-Gly-NH2) on the permeability of the blood-brain barrier (BBB) to a large protein and a small anion were studied using radioiodinated serum albumin (RISA) and 99mTc-labeled sodium pertechnetate. The permeability of the BBB to RISA was unaltered by either peptide. Permeability to the inorganic pertechnetate anion, however, was significantly increased by alpha-MSH but not by MIF-1 at doses known to evoke EEG and behavioral responses. The peptides did not cause a change in the systemic blood pressure. It is possible, therefore, that at least some CNS effects of peripherally administered peptides are exerted by alteration of the permeability of the BBB to other substances

  9. Prezygotic barriers to hybridization in marine broadcast spawners: reproductive timing and mating system variation.

    Directory of Open Access Journals (Sweden)

    Carla A Monteiro

    Full Text Available Sympatric assemblages of congeners with incomplete reproductive barriers offer the opportunity to study the roles that ecological and non-ecological factors play in reproductive isolation. While interspecific asynchrony in gamete release and gametic incompatibility are known prezygotic barriers to hybridization, the role of mating system variation has been emphasized in plants. Reproductive isolation between the sibling brown algal species Fucus spiralis, Fucus guiryi (selfing hermaphrodite and Fucus vesiculosus (dioecious was studied because they form hybrids in parapatry in the rocky intertidal zone, maintain species integrity over a broad geographic range, and have contrasting mating systems. We compared reproductive synchrony (spawning overlap between the three species at several temporal scales (yearly/seasonal, semilunar/tidal, and hourly during single tides. Interspecific patterns of egg release were coincident at seasonal (single peak in spring to early summer to semilunar timescales. Synthesis of available data indicated that spawning is controlled by semidiurnal tidal and daily light-dark cues, and not directly by semilunar cycles. Importantly, interspecific shifts in timing detected at the hourly scale during single tides were consistent with a partial ecological prezygotic hybridization barrier. The species displayed patterns of gamete release consistent with a power law distribution, indicating a high degree of reproductive synchrony, while the hypothesis of weaker selective constraints for synchrony in selfing versus outcrossing species was supported by observed spawning in hermaphrodites over a broader range of tidal phase than in outcrossers. Synchronous gamete release is critical to the success of external fertilization, while high-energy intertidal environments may offer only limited windows of reproductive opportunity. Within these windows, however, subtle variations in reproductive timing have evolved with the potential to

  10. Safety indicators used to prove the role of natural barrier for Saligny near surface disposal system

    International Nuclear Information System (INIS)

    Niculae, Ortenzia; Durdun, I.; Ionita, Gh.

    2007-01-01

    Full text: The siting process for a near surface repository suitable for the radioactive waste resulted from Cernavoda NPP operation and decommissioning (low level radioactive waste with small amounts of long lived radionuclides) started in 1992 and it included the collection of data from specific field and laboratory works for each site selection stage as well as different safety performance evaluation. According to the IAEA standards (Safety Guide No.111-G-3.1, 1994), the purpose of the siting process is not to get the best solution but to find out 'an acceptable solution, with sufficient safety reserves'. Since 1996, detailed field and investigation works were performed in Saligny preferred site including an experimental area to test the improvement method proposed for the foundation ground of repository, as well as detailed performance assessments using specific computer codes. The paper presents the results of recent performance assessments for the natural barrier of disposal system. The calculations were done using HYDRUS 2D, FEHM and AMBER computer codes. The endpoint of the Safety Report for Siting a Near Surface Repository at Saligny Site [CITON and SCN, Safety Report for Siting a Near Surface Repository at Saligny Site, 2007, pages 8.2.1-1 to 8.2.1-22 and 8-63 to 8-70] was the assessment of safety indicators. Individual annual effective dose for exposed peoples (both workers and general public) was the main safety indicator. In the same document, the radionuclide concentration in the disposal system compartments has been evaluated, as supplementary safety indicator of repository barriers (especially to confirm the natural barrier performance). The results confirmed the performance of natural barrier: the maximum extension of H-3 and Co-60 contaminant plume after repository closure remains more above underground water level. In the aquifer, iodine concentration reaches a value of 10 -15 mol/l, at the same magnitude order with the admitted limit from CFR

  11. The Mechanisms and Quantification of the Selective Permeability in Transport Across Biological Barriers : the Example of Kyotorphin

    NARCIS (Netherlands)

    Serrano, Isa D.; Freire, Joao M.; Carvalho, Miguel V.; Neves, Mafalda; Melo, Manuel N.; Castanho, Miguel A. R. B.

    2014-01-01

    This paper addresses the mechanisms behind selective endothelial permeability and their regulations. The singular properties of each of the seven blood-tissues barriers. Then, it further revisits the physical, quantitative meaning of permeability, and the way it should be measured based on sound

  12. Benchtop evaluation of pressure barrier insufflator and standard insufflator systems.

    Science.gov (United States)

    Nepple, Kenneth G; Kallogjeri, Dorina; Bhayani, Sam B

    2013-01-01

    Previous experimental research has reported minimal differences in pressure maintenance between different versions of standard insufflators (SI). However, a recent report identified potential clinical benefits with a valveless pressure barrier insufflator (PBI). We sought to perform a benchtop objective evaluation of SI and PBI systems. A rigid box system with continuous pressure manometry was used to evaluate a PBI (Surgiquest Airseal) and two SIs (SI1 = Stryker PneumoSure High Flow Insufflator and SI2 = Storz SCB Thermoflator). Pressure maintenance of 15 mmHg was evaluated during experimental conditions of leakage from a 5 mm port site, leakage from a 12 mm port site, and continuous suction. With leakage from the 5 mm port site, the PBI maintained pressure of >13 mmHg whereas the pressures dropped moderately with the SI1 (7-13 mmHg) and SI2 insufflators (3-7 mmHg) and did not regain goal pressure until leakage was stopped. With leakage from 12 mm port site, the PBI pressure decreased to 9-11 mmHg, whereas the SI1 and SI2 lost insufflation pressures completely. The PBI maintained pressure of >11 mmHg during continuous suction while the SI1 and SI2 lost pressure entirely, and actually showed negative pressure from air suction into the rigid box system. When evaluated statistically with the mixed model repeated measures ANOVA, the SI1 and SI2 performed similarly while the PBI maintained increased pressure. In the experimental rigid box system, the PBI more successfully maintained pressure in response to leakage and suction than SIs.

  13. Evaluation of the Effectiveness of Stormwater Decision Support Tools for Infrastructure Selection and the Barriers to Implementation

    Science.gov (United States)

    Spahr, K.; Hogue, T. S.

    2016-12-01

    Selecting the most appropriate green, gray, and / or hybrid system for stormwater treatment and conveyance can prove challenging to decision markers across all scales, from site managers to large municipalities. To help streamline the selection process, a multi-disciplinary team of academics and professionals is developing an industry standard for selecting and evaluating the most appropriate stormwater management technology for different regions. To make the tool more robust and comprehensive, life-cycle cost assessment and optimization modules will be included to evaluate non-monetized and ecosystem benefits of selected technologies. Initial work includes surveying advisory board members based in cities that use existing decision support tools in their infrastructure planning process. These surveys will qualify the decisions currently being made and identify challenges within the current planning process across a range of hydroclimatic regions and city size. Analysis of social and other non-technical barriers to adoption of the existing tools is also being performed, with identification of regional differences and institutional challenges. Surveys will also gage the regional appropriateness of certain stormwater technologies based off experiences in implementing stormwater treatment and conveyance plans. In additional to compiling qualitative data on existing decision support tools, a technical review of components of the decision support tool used will be performed. Gaps in each tool's analysis, like the lack of certain critical functionalities, will be identified and ease of use will be evaluated. Conclusions drawn from both the qualitative and quantitative analyses will be used to inform the development of the new decision support tool and its eventual dissemination.

  14. The advantages and barriers in the implementation of a substance dependence treatment information system (SDTIS

    Directory of Open Access Journals (Sweden)

    Sima Ajami

    2015-01-01

    Full Text Available Addiction is a phenomenon that causes structural changes in different systems of society. Studies show for planning of addiction prevention and treatment, it is necessary to create an information management system. Substance dependence information systems refer to systems which collect, analyse and report data related to substance dependence information. The aim of this study was to identify advantages and barriers to implement Substance Dependence Treatment Information System (SDTIS. This study was a narrative review. Our review divided into three phases: literature collection, assessing, and selection. We employed the following keywords and their combinations in different areas of articles. In this study, 22 of collected articles and reports were selected based on their relevancy. We found many advantages for a substance dependence treatment information system such as recording sufficient, complete and accurate information and easy and timely access to them and monitoring and enhancing the quality of care received by patients. But we may face some concerns for implementing this information system like taking time and funds from client services, being expensive or even problems regarding the quality of data contained in these information systems. There are some important problems in the way of implementing. In order to overcome these issues, we need to raise community awareness.

  15. The advantages and barriers in the implementation of a substance dependence treatment information system (SDTIS).

    Science.gov (United States)

    Ajami, Sima; Mellat-Karkevandi, Zahra

    2015-11-01

    Addiction is a phenomenon that causes structural changes in different systems of society. Studies show for planning of addiction prevention and treatment, it is necessary to create an information management system. Substance dependence information systems refer to systems which collect, analyse and report data related to substance dependence information. The aim of this study was to identify advantages and barriers to implement Substance Dependence Treatment Information System (SDTIS). This study was a narrative review. Our review divided into three phases: literature collection, assessing, and selection. We employed the following keywords and their combinations in different areas of articles. In this study, 22 of collected articles and reports were selected based on their relevancy. We found many advantages for a substance dependence treatment information system such as recording sufficient, complete and accurate information and easy and timely access to them and monitoring and enhancing the quality of care received by patients. But we may face some concerns for implementing this information system like taking time and funds from client services, being expensive or even problems regarding the quality of data contained in these information systems. There are some important problems in the way of implementing. In order to overcome these issues, we need to raise community awareness.

  16. Improving safety culture in hospitals: Facilitators and barriers to implementation of Systemic Falls Investigative Method (SFIM).

    Science.gov (United States)

    Zecevic, Aleksandra A; Li, Alvin Ho-Ting; Ngo, Charity; Halligan, Michelle; Kothari, Anita

    2017-06-01

    The purpose of this study was to assess the facilitators and barriers to implementation of the Systemic Falls Investigative Method (SFIM) on selected hospital units. A cross-sectional explanatory mixed methods design was used to converge results from a standardized safety culture survey with themes that emerged from interviews and focus groups. Findings were organized by six elements of the Ottawa Model of Research Use framework. A geriatric rehabilitation unit of an acute care hospital and a neurological unit of a rehabilitation hospital were selected purposefully due to the high frequency of falls. Hospital staff who took part in: surveys (n = 39), interviews (n = 10) and focus groups (n = 12), and 38 people who were interviewed during falls investigations: fallers, family, unit staff and hospital management. Implementation of the SFIM to investigate fall occurrences. Percent of positive responses on the Modified Stanford Patient Safety Culture Survey Instrument converged with qualitative themes on facilitators and barriers for intervention implementation. Both hospital units had an overall poor safety culture which hindered intervention implementation. Facilitators were hospital accreditation, strong emphasis on patient safety, infrastructure and dedicated champions. Barriers included heavy workloads, lack of time, lack of resources and poor communication. Successful implementation of SFIM requires regulatory and organizational support, committed frontline staff and allocation of resources to identify active causes and latent contributing factors to falls. System-wide adjustments show promise for promotion of safety culture in hospitals where falls happen regularly. © The Author 2017. Published by Oxford University Press in association with the International Society for Quality in Health Care. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

  17. Expert System Model for Educational Personnel Selection

    Directory of Open Access Journals (Sweden)

    Héctor A. Tabares-Ospina

    2013-06-01

    Full Text Available The staff selection is a difficult task due to the subjectivity that the evaluation means. This process can be complemented using a system to support decision. This paper presents the implementation of an expert system to systematize the selection process of professors. The management of software development is divided into 4 parts: requirements, design, implementation and commissioning. The proposed system models a specific knowledge through relationships between variables evidence and objective.

  18. Analysis of Barriers against Wheat Farmers' Participation in the Formation of Water Users Association: the Case of Dez Irrigation System

    Directory of Open Access Journals (Sweden)

    ali pazhuhan

    2016-11-01

    The present study was aimed at analyzing the barriers against wheat farmers' participation in the formation of water users association within the framework of a descriptive survey. The sample of this study included 375 wheat farmers in Dez irrigation system who were selected through random cluster sampling and were studied through a questionnaire. The reliability index of this questionnaire was estimated to be 0.89. The content validity of the questionnaire was confirmed by the experts and scholars in the field. After the participants filled the questionnaires and the data were collected, the SPSS software package was used to analyze the data. In addition, the results of factor analysis related to the items of barriers led to the extraction of four barriers. These barriers, in order of importance, include the lack of proper infrastructures and economic facilities, social barriers, inadequate structural characteristics and lack of risk-taking, local organizations and lack of attention to extension activities that explain 60.78 percent of the variance of all the barriers.

  19. Performance evaluation of cable median barrier systems in Texas.

    Science.gov (United States)

    2009-08-01

    Since 2003, the Texas Department of Transportation (TxDOT) has embarked on an aggressive campaign to install : median barriers to prevent cross-median crashes on freeway facilities statewide. In the few years prior to 2003, : virtually all fatalities...

  20. Development of guidelines for cable median barrier systems in Texas.

    Science.gov (United States)

    2009-12-01

    Since 2003, the Texas Department of Transportation (TxDOT) has embarked on an aggressive campaign to install : median barriers to prevent cross-median crashes on freeway facilities statewide. In the few years prior to 2003, : virtually all fatalities...

  1. Selection strategy for the most Suitable CEC method for clay barrier characterisation

    International Nuclear Information System (INIS)

    Dohrmann, R.; Kaufhold, S.

    2010-01-01

    Document available in extended abstract form only. The cation exchange capacity (CEC) is one of the most relevant properties of clay barriers. CEC results often are used for characterization of the clay host rock or for sensitive detection of degradation of the barrier material, e.g. bentonite buffer. Numerous methods exist for the determination of the CEC and exchangeable cations. However, a lot of methods suffer from systematic errors. These errors are caused by interactions (that differ from cation exchange) of the exchange solutions used with minerals in the barrier material: i) Dissolution of soluble minerals such as calcite, gypsum, or dolomite which causes inflated exchangeable calcium (magnesium) values. Other reactions of carbonates or gypsum not only affect exchangeable cations but also the CEC (index cation) values in a way that ii) witherite (barium carbonate) is formed and dissolved later (barium chloride method) which causes inflated CEC values or iii) rests of gypsum are present during reexchange with magnesium chloride (barium chloride method) which then leads to drastic CEC underestimation by formation of barium sulphate (here simultaneously barium ions are desorbed from exchange positions and sulphate enters the solution due to gypsum dissolution). When the ammonium acetate method is used for CEC determination of calcareous clays/bentonites another mechanism for a systematic CEC decrease occurs: iv) ammonium acetate is first used to saturate the clay components in a regular way (cation exchange), but during washing for removal of excess salt, ammonium is desorbed again from exchange positions by calcium which is liberated (dissolved) from remaining calcite of calcareous clays studied. Other errors may be v) the degradation of cationic complexes (silver thiourea, if pH > 8) or vi) substances which are added to adjust the pH of the exchange solutions such as triethanolamine in barium chloride exchange solution which may be protonated and adsorbed in

  2. The Effects of information barrier requirements on the trilateral initiative attribute measurement system (AVNG)

    International Nuclear Information System (INIS)

    MacArthur, D.W.; Langner, D.C.; Whiteson, R.; Wolford, J.K.

    2001-01-01

    Although the detection techniques used for measuring classified materials are very similar to those used in unclassified measurements, the surrounding packaging is generally very different. If iZ classified item is to be measured, an information barrier is required to protect any classified data acquired. This information barrier must protect the classified information while giving the inspector confidence that the unclassified outputs accurately reflect the classified inputs, Both information barrier and authentication considerations must be considered during all phases of system design and fabrication. One example of such a measurement system is the attribute measurement system (termed the AVNG) designed for the: Trilateral Initiative. We will discuss the integration of information barrier components into this system as well as the effects of an information barrier (including authentication) concerns on the implementation of the detector systems.

  3. Method for Business Process Management System Selection

    OpenAIRE

    Westelaken, van de, Thijs; Terwee, Bas; Ravesteijn, Pascal

    2013-01-01

    In recent years business process management (BPM) and specifically information systems that support the analysis, design and execution of processes (also called business process management systems (BPMS)) are getting more attention. This has lead to an increase in research on BPM and BPMS. However the research on BPMS is mostly focused on the architecture of the system and how to implement such systems. How to select a BPM system that fits the strategy and goals of a specific organization is ...

  4. Barriers and opportunities: A review of selected successful energy-efficiency programs

    International Nuclear Information System (INIS)

    Worrell, Ernst; Price, Lynn

    2001-01-01

    In industry, barriers may exist at various points in the decision making process, and in the implementation and management of measures to improve energy efficiency. Barriers may take many forms, and are determined by the business environment and include decision-making processes, energy prices, lack of information, a lack of confidence in the information, or high transaction costs for obtaining reliable information, as well as limited capital availability. Other barriers are the ''invisibility'' of energy efficiency measures and the difficulty of quantifying the impacts, and slow diffusion of innovative technology into markets while firms typically under-invest in R and D, despite the high pay-backs. Various programs try to reduce the barriers to improve the uptake of innovative technologies. A wide array of policies has been used and tested in the industrial sector in industrialized countries, with varying success rates. We review some new approaches to industrial energy efficiency improvement in industrialized countries, focusing on voluntary agreements

  5. Laboratory and field scale demonstration of reactive barrier systems

    International Nuclear Information System (INIS)

    Dwyer, B.P.; Marozas, D.C.; Cantrell, K.; Stewart, W.

    1996-10-01

    In an effort to devise a cost efficient technology for remediation of uranium contaminated groundwater, the Department of Energy's Uranium Mill Tailings Remedial Action (DOE-UMTRA) Program through Sandia National Laboratories (SNL) fabricated a pilot scale research project utilizing reactive subsurface barriers at an UMTRA site in Durango, Colorado. A reactive subsurface barrier is produced by placing a reactant material (in this experiment, metallic iron) in the flow path of the contaminated groundwater. The reactive media then removes and/or transforms the contaminant(s) to regulatory acceptable levels. Experimental design and results are discussed with regard to other potential applications of reactive barrier remediation strategies at other sites with contaminated groundwater problems

  6. Overcoming energy efficiency barriers through systems approach—A conceptual framework

    International Nuclear Information System (INIS)

    Chai, Kah-Hin; Yeo, Catrina

    2012-01-01

    In this paper we propose a framework which categorizes energy efficiency barriers based on the stage at which the barriers exist. Barriers to energy efficiency have been widely studied but to our knowledge, except for a few studies, we found inadequate consideration for barrier–barrier interactions when proposing policy measures for improving energy efficiency. Leveraging systems thinking's power as a problem solver which identifies underlying structure that explains (similar) patterns of behavior in a variety of different situations, we attempted to identify patterns of barriers to adoption of energy efficiency measures in industrial companies. Inspired by systems thinking, the proposed framework has four stages, namely, Motivation, Capability, Implementation and Results, as well as a feedback loop. Using a case study, we show that following the four stages will lead to positive feedback for future energy efficiency implementations. The framework highlights the interconnected nature of the barriers and a need for policymakers to address these barriers in a holistic manner. We argue that the overall effectiveness of energy efficiency policies is only as strong as the weakest link in the four-stage framework. This differs from most prior research that addressed barriers in isolation, where a solution is proposed for each of the barriers without considering the relationship between the barriers. Our framework also offers a way to understand the roles and responsibilities of major stakeholders such as governments and energy service companies (ESCOs) in driving energy efficiency. This allows the assessment and identification of weak links in energy efficiency policies. - Highlights: ► We propose a systems approach to overcome energy efficiency barriers. ► Barriers are grouped into Motivation, Capability, Implementation and Results. ► Case study shows that there is a feedback loop from Results to Motivation. ► Current Results will affect future Motivation.

  7. Preliminary engineering specifications for a test demonstration multilayer protective barrier cover system

    International Nuclear Information System (INIS)

    Phillips, S.J.; Gilbert, T.W.; Adams, M.R.

    1985-03-01

    This report presents preliminary engineering specifications for a test protective barrier cover system and support radiohydrology facility to be constructed at the Hanford Protective Barrier Test Facility (PBTF). Construction of this test barrier and related radiohydrology facility is part of a continuing effort to provide construction experience and performance evaluation of alternative barrier designs used for long-term isolation of disposed radioactive waste materials. Design specifications given in this report are tentative, based on interim engineering and computer simulation design efforts. Final definitive design specifications and engineering prints will be produced in FY 1986. 6 refs., 10 figs., 1 tab

  8. Barriers for Students' Learning of Holistic Systems Development

    DEFF Research Database (Denmark)

    Levinsen, Karin; Madsen, Sabine

    2007-01-01

    Ud fra aktionsforskning af faget Informationsbehandling på bachelorprogrammet HA/DØK ved Copenhagen Business School undersøger vi i denne artikel hvilke barriere de studerende oplever i forbindelse med læring af holistisk systemudvikling og hvorfor. Siden 1980'erne har man i (dele af) litteraturen...

  9. Multiuser hybrid switched-selection diversity systems

    KAUST Repository

    Shaqfeh, Mohammad

    2011-09-01

    A new multiuser scheduling scheme is proposed and analyzed in this paper. The proposed system combines features of conventional full-feedback selection-based diversity systems and reduced-feedback switch-based diversity systems. The new hybrid system provides flexibility in trading-off the channel information feedback overhead with the prospected multiuser diversity gains. The users are clustered into groups, and the users\\' groups are ordered into a sequence. Per-group feedback thresholds are used and optimized to maximize the system overall achievable rate. The proposed hybrid system applies switched diversity criterion to choose one of the groups, and a selection criterion to decide the user to be scheduled from the chosen group. Numerical results demonstrate that the system capacity increases as the number of users per group increases, but at the cost of more required feedback messages. © 2011 IEEE.

  10. Understanding the barriers to physician error reporting and disclosure: a systemic approach to a systemic problem.

    Science.gov (United States)

    Perez, Bianca; Knych, Stephen A; Weaver, Sallie J; Liberman, Aaron; Abel, Eileen M; Oetjen, Dawn; Wan, Thomas T H

    2014-03-01

    The issues of medical errors and medical malpractice have stimulated significant interest in establishing transparency in health care, in other words, ensuring that medical professionals formally report medical errors and disclose related outcomes to patients and families. However, research has amply shown that transparency is not a universal practice among physicians. A review of the literature was carried out using the search terms "transparency," "patient safety," "disclosure," "medical error," "error reporting," "medical malpractice," "doctor-patient relationship," and "physician" to find articles describing physician barriers to transparency. The current literature underscores that a complex Web of factors influence physician reluctance to engage in transparency. Specifically, 4 domains of barriers emerged from this analysis: intrapersonal, interpersonal, institutional, and societal. Transparency initiatives will require vigorous, interdisciplinary efforts to address the systemic and pervasive nature of the problem. Several ethical and social-psychological barriers suggest that medical schools and hospitals should collaborate to establish continuity in education and ensure that knowledge acquired in early education is transferred into long-term learning. At the institutional level, practical and cultural barriers suggest the creation of supportive learning environments and private discussion forums where physicians can seek moral support in the aftermath of an error. To overcome resistance to culture transformation, incremental change should be considered, for example, replacing arcane transparency policies and complex reporting mechanisms with clear, user-friendly guidelines.

  11. Control Configuration Selection for Multivariable Descriptor Systems

    DEFF Research Database (Denmark)

    Shaker, Hamid Reza; Stoustrup, Jakob

    2012-01-01

    Control configuration selection is the procedure of choosing the appropriate input and output pairs for the design of SISO (or block) controllers. This step is an important prerequisite for a successful industrial control strategy. In industrial practices it is often the case that the system, whi...... is that it can be used to propose a richer sparse or block diagonal controller structure. The interaction measure is used for control configuration selection of the linearized CSTR model with descriptor from....

  12. Cell-to-Cell Contact Results in a Selective Translocation of Maternal Human Immunodeficiency Virus Type 1 Quasispecies across a Trophoblastic Barrier by both Transcytosis and Infection

    Science.gov (United States)

    Lagaye, S.; Derrien, M.; Menu, E.; Coïto, C.; Tresoldi, E.; Mauclère, P.; Scarlatti, G.; Chaouat, G.; Barré-Sinoussi, F.; Bomsel, M.

    2001-01-01

    Mother-to-child transmission can occur in utero, mainly intrapartum and postpartum in case of breastfeeding. In utero transmission is highly restricted and results in selection of viral variant from the mother to the child. We have developed an in vitro system that mimics the interaction between viruses, infected cells present in maternal blood, and the trophoblast, the first barrier protecting the fetus. Trophoblastic BeWo cells were grown as a tight polarized monolayer in a two-chamber system. Cell-free virions applied to the apical pole neither crossed the barrier nor productively infected BeWo cells. In contrast, apical contact with human immunodeficiency virus (HIV)-infected peripheral blood mononuclear cells (PBMCs) resulted in transcytosis of infectious virus across the trophoblastic monolayer and in productive infection correlating with the fusion of HIV-infected PBMCs with trophoblasts. We showed that viral variants are selected during these two steps and that in one case of in utero transmission, the predominant maternal viral variant characterized after transcytosis was phylogenetically indistinguishable from the predominant child's virus. Hence, the first steps of transmission of HIV-1 in utero appear to involve the interaction between HIV type 1-infected cells and the trophoblastic layer, resulting in the passage of infectious HIV by transcytosis and by fusion/infection, both leading to a selection of virus quasispecies. PMID:11312350

  13. Disposal systems evaluations and tool development: Engineered Barrier System (EBS) evaluation

    International Nuclear Information System (INIS)

    Rutqvist, Jonny; Liu, Hui-Hai; Steefel, Carl I.; Serrano de Caro, M.A.; Caporuscio, Florie Andre; Birkholzer, Jens T.; Blink, James A.; Sutton, Mark A.; Xu, Hongwu; Buscheck, Thomas A.; Levy, Schon S.; Tsang, Chin-Fu; Sonnenthal, Eric; Halsey, William G.; Jove-Colon, Carlos F.; Wolery, Thomas J.

    2011-01-01

    Key components of the nuclear fuel cycle are short-term storage and long-term disposal of nuclear waste. The latter encompasses the immobilization of used nuclear fuel (UNF) and radioactive waste streams generated by various phases of the nuclear fuel cycle, and the safe and permanent disposition of these waste forms in geological repository environments. The engineered barrier system (EBS) plays a very important role in the long-term isolation of nuclear waste in geological repository environments. EBS concepts and their interactions with the natural barrier are inherently important to the long-term performance assessment of the safety case where nuclear waste disposition needs to be evaluated for time periods of up to one million years. Making the safety case needed in the decision-making process for the recommendation and the eventual embracement of a disposal system concept requires a multi-faceted integration of knowledge and evidence-gathering to demonstrate the required confidence level in a deep geological disposal site and to evaluate long-term repository performance. The focus of this report is the following: (1) Evaluation of EBS in long-term disposal systems in deep geologic environments with emphasis on the multi-barrier concept; (2) Evaluation of key parameters in the characterization of EBS performance; (3) Identification of key knowledge gaps and uncertainties; and (4) Evaluation of tools and modeling approaches for EBS processes and performance. The above topics will be evaluated through the analysis of the following: (1) Overview of EBS concepts for various NW disposal systems; (2) Natural and man-made analogs, room chemistry, hydrochemistry of deep subsurface environments, and EBS material stability in near-field environments; (3) Reactive Transport and Coupled Thermal-Hydrological-Mechanical-Chemical (THMC) processes in EBS; and (4) Thermal analysis toolkit, metallic barrier degradation mode survey, and development of a Disposal Systems

  14. Disposal systems evaluations and tool development : Engineered Barrier System (EBS) evaluation.

    Energy Technology Data Exchange (ETDEWEB)

    Rutqvist, Jonny (LBNL); Liu, Hui-Hai (LBNL); Steefel, Carl I. (LBNL); Serrano de Caro, M. A. (LLNL); Caporuscio, Florie Andre (LANL); Birkholzer, Jens T. (LBNL); Blink, James A. (LLNL); Sutton, Mark A. (LLNL); Xu, Hongwu (LANL); Buscheck, Thomas A. (LLNL); Levy, Schon S. (LANL); Tsang, Chin-Fu (LBNL); Sonnenthal, Eric (LBNL); Halsey, William G. (LLNL); Jove-Colon, Carlos F.; Wolery, Thomas J. (LLNL)

    2011-01-01

    Key components of the nuclear fuel cycle are short-term storage and long-term disposal of nuclear waste. The latter encompasses the immobilization of used nuclear fuel (UNF) and radioactive waste streams generated by various phases of the nuclear fuel cycle, and the safe and permanent disposition of these waste forms in geological repository environments. The engineered barrier system (EBS) plays a very important role in the long-term isolation of nuclear waste in geological repository environments. EBS concepts and their interactions with the natural barrier are inherently important to the long-term performance assessment of the safety case where nuclear waste disposition needs to be evaluated for time periods of up to one million years. Making the safety case needed in the decision-making process for the recommendation and the eventual embracement of a disposal system concept requires a multi-faceted integration of knowledge and evidence-gathering to demonstrate the required confidence level in a deep geological disposal site and to evaluate long-term repository performance. The focus of this report is the following: (1) Evaluation of EBS in long-term disposal systems in deep geologic environments with emphasis on the multi-barrier concept; (2) Evaluation of key parameters in the characterization of EBS performance; (3) Identification of key knowledge gaps and uncertainties; and (4) Evaluation of tools and modeling approaches for EBS processes and performance. The above topics will be evaluated through the analysis of the following: (1) Overview of EBS concepts for various NW disposal systems; (2) Natural and man-made analogs, room chemistry, hydrochemistry of deep subsurface environments, and EBS material stability in near-field environments; (3) Reactive Transport and Coupled Thermal-Hydrological-Mechanical-Chemical (THMC) processes in EBS; and (4) Thermal analysis toolkit, metallic barrier degradation mode survey, and development of a Disposal Systems

  15. Barriers to Mitigate Carbon Footprint in a Selected Academic Institution in Bacoor City, Cavite, Philippines

    Science.gov (United States)

    Adanza, Jonathan R.

    2016-01-01

    Carbon footprint is an environmental menace that needs to be addressed at once. Various mitigating measures were proposed and yet manifestations of its proliferation are very much observable. This study seeks to determine primarily the barriers of non-adherence to identified measures to mitigate carbon footprint in the environment. Using the mixed…

  16. Chemisorption on size-selected metal clusters: activation barriers and chemical reactions for deuterium and aluminum cluster ions

    International Nuclear Information System (INIS)

    Jarrold, M.F.; Bower, J.E.

    1988-01-01

    The authors describe a new approach to investigating chemisorption on size-selected metal clusters. This approach involves investigating the collision-energy dependence of chemisorption using low-energy ion beam techniques. The method provides a direct measure of the activation barrier for chemisorption and in some cases an estimate of the desorption energy as well. They describe the application of this technique to chemisorption of deuterium on size-selected aluminum clusters. The activation barriers increase with cluster size (from a little over 1 eV for Al 10 + to around 2 eV for Al 27 + ) and show significant odd-even oscillations. The activation barriers for the clusters with an odd number of atoms are larger than those for the even-numbered clusters. In addition to chemisorption of deuterium onto the clusters, chemical reactions were observed, often resulting in cluster fragmentation. The main products observed were Al/sub n-1/D + , Al/sub n-2/ + , and Al + for clusters with n + and Al/sub n-1/D + for the larger clusters

  17. Barriers to the use of mobile sales force automation systems: a salesperson’s perspective

    OpenAIRE

    Sinisalo, Jaakko; Karjaluoto, Heikki; Saraniemi, Saila

    2015-01-01

    Purpose – The purpose of this paper is to examine the barriers associated with the adoption and use of mobile sales force automation (SFA) systems from a salesperson’s perspective. Design/methodology/approach – A qualitative investigation of two business-to-business companies was conducted. Data collected from ten semi-structured interviews with directors or sales managers were analyzed to understand the main barriers to SFA system adoption. Findings – The study confirms the ex...

  18. Coping with the knowledge sharing barriers in Product Service Systems design

    OpenAIRE

    Bertoni, Marco; Larsson, Andreas

    2010-01-01

    This paper analyzes the knowledge sharing process that characterizes Product Service Systems (PSS) design, drawing on data from an in-depth study in the Swedish manufacturing industry. It categorizes and describes the most relevant knowledge sharing barriers affecting early PSS development phases, discussing them in terms of capabilities to be included in a knowledge engineering system to fulfil the increasing need for knowledge in product-service design. To cope with these barriers, the auth...

  19. A path method for finding energy barriers and minimum energy paths in complex micromagnetic systems

    International Nuclear Information System (INIS)

    Dittrich, R.; Schrefl, T.; Suess, D.; Scholz, W.; Forster, H.; Fidler, J.

    2002-01-01

    Minimum energy paths and energy barriers are calculated for complex micromagnetic systems. The method is based on the nudged elastic band method and uses finite-element techniques to represent granular structures. The method was found to be robust and fast for both simple test problems as well as for large systems such as patterned granular media. The method is used to estimate the energy barriers in CoCr-based perpendicular recording media

  20. Selective ablation of the androgen receptor in mouse sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development.

    Directory of Open Access Journals (Sweden)

    Ariane Willems

    2010-11-01

    Full Text Available The observation that mice with a selective ablation of the androgen receptor (AR in Sertoli cells (SC (SCARKO mice display a complete block in meiosis supports the contention that SC play a pivotal role in the control of germ cell development by androgens. To delineate the physiological and molecular mechanism responsible for this control, we compared tubular development in pubertal SCARKO mice and littermate controls. Particular attention was paid to differences in SC maturation, SC barrier formation and cytoskeletal organization and to the molecular mediators potentially involved. Functional analysis of SC barrier development by hypertonic perfusion and lanthanum permeation techniques and immunohistochemical analysis of junction formation showed that SCARKO mice still attempt to produce a barrier separating basal and adluminal compartment but that barrier formation is delayed and defective. Defective barrier formation was accompanied by disturbances in SC nuclear maturation (immature shape, absence of prominent, tripartite nucleoli and SC polarization (aberrant positioning of SC nuclei and cytoskeletal elements such as vimentin. Quantitative RT-PCR was used to study the transcript levels of genes potentially related to the described phenomena between day 8 and 35. Differences in the expression of SC genes known to play a role in junction formation could be shown from day 8 for Cldn11, from day 15 for Cldn3 and Espn, from day 20 for Cdh2 and Jam3 and from day 35 for ZO-1. Marked differences were also noted in the transcript levels of several genes that are also related to cell adhesion and cytoskeletal dynamics but that have not yet been studied in SC (Actn3, Ank3, Anxa9, Scin, Emb, Mpzl2. It is concluded that absence of a functional AR in SC impedes the remodeling of testicular tubules expected at the onset of spermatogenesis and interferes with the creation of the specific environment needed for germ cell development.

  1. Study on vibration behaviors of engineered barrier system

    Energy Technology Data Exchange (ETDEWEB)

    Mikoshiba, Tadashi; Ogawa, Nobuyuki; Minowa, Chikahiro [National Research Inst. for Earth Science and Disaster Prevention, Tsukuba, Ibaraki (Japan)

    1999-02-01

    Small engineered barrier model was mode and tested by vibrating with the random wave and the real earthquake wave. The wave observed at Kamaishi (N-S, N-W), Iwate Prefecture, in September 6, 1993, and Kobe (N-S) etc. were used as the real earthquake waves. The trial overpack showed non-linear characteristics (soft spring) by vibrating with the random wave. The pressure and acceleration of trial overpack and constraint container increased with increasing the vibration level of the real earthquake wave. The trial overpack moved the maximum 1.7 mm of displacement and 16 mm subsidence. The results showed both waves rocked the trialpack. (S.Y.)

  2. CHARACTERIZATION OF BENTONITE FOR ENGINEERED BARRIER SYSTEMS IN RADIOACTIVE WASTE DISPOSAL SITES

    Directory of Open Access Journals (Sweden)

    Dubravko Domitrović

    2012-07-01

    Full Text Available Engineered barrier systems are used in radioactive waste disposal sites in order to provide better protection of humans and the environment from the potential hazards associated with the radioactive waste disposal. The engineered barrier systems usually contain cement or clay (bentonite because of their isolation properties and long term performance. Quality control tests of clays are the same for all engineering barrier systems. Differences may arise in the required criteria to be met due for different application. Prescribed clay properties depend also on the type of host rocks. This article presents radioactive waste management based on best international practice. Standard quality control procedures for bentonite used as a sealing barrier in radioactive waste disposal sites are described as some personal experiences and results of the index tests (free swelling index, water adsorption capacity, plasticity limits and hydraulic permeability of bentonite (the paper is published in Croatian.

  3. Progress of the AVNG System - Attribute Verification System with Information Barriers for Mass Isotopics Measurements

    International Nuclear Information System (INIS)

    Budnikov, D.; Bulatov, M.; Jarikhine, I.; Lebedev, B.; Livke, A.; Modenov, A.; Morkin, A.; Razinkov, S.; Tsaregorodtsev, D.; Vlokh, A.; Yakovleva, S.; Elmont, T.H.; Langner, D.C.; MacArthur, D.W.; Mayo, D.R.; Smith, M.K.; Luke, S.J.

    2005-01-01

    An attribute verification system (AVNG) with information barriers for mass and isotopics measurements has been designed and its fabrication is nearly completed. The AVNG is being built by scientists at the Russian Federal Nuclear Center-VNIIEF, with support of Los Alamos National Laboratory (LANL) and Lawrence Livermore National Laboratory (LLNL). Such a system could be used to verify the presence of several unclassified attributes of classified material with no classified information release. The system is comprised of a neutron multiplicity counter and gamma-spectrometry system based on a high purity germanium gamma detector (nominal relative efficiency @ 1332 keV 50%) and digital gamma-ray spectrometer DSPEC PLUS . The neutron multiplicity counter is a three ring counter with 164 3 He tubes. The system was designed to measure prototype containers 491 mm in diameter and 503 mm high. This paper provides a brief history of the project and documents the progress of this effort with drawings and photographs.

  4. Selecting RMF Controls for National Security Systems

    Energy Technology Data Exchange (ETDEWEB)

    Witzke, Edward L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-08-01

    In 2014, the United States Department of Defense started tra nsitioning the way it performs risk management and accreditation of informatio n systems to a process entitled Risk Management Framework for DoD Information Technology or RMF for DoD IT. There are many more security and privacy contro ls (and control enhancements) from which to select in RMF, than there w ere in the previous Information Assurance process. This report is an attempt t o clarify the way security controls and enhancements are selected. After a brief overview and comparison of RMF for DoD I T with the previously used process, this report looks at the determination of systems as National Security Systems (NSS). Once deemed to be an NSS, this report addr esses the categorization of the information system with respect to impact level s of the various security objectives and the selection of an initial baseline o f controls. Next, the report describes tailoring the controls through the use of overl ays and scoping considerations. Finally, the report discusses organizatio n-defined values for tuning the security controls to the needs of the information system.

  5. Development of an Integrated Natural Barrier Database System for Site Evaluation of a Deep Geologic Repository in Korea - 13527

    International Nuclear Information System (INIS)

    Jung, Haeryong; Lee, Eunyong; Jeong, YiYeong; Lee, Jeong-Hwan

    2013-01-01

    Korea Radioactive-waste Management Corporation (KRMC) established in 2009 has started a new project to collect information on long-term stability of deep geological environments on the Korean Peninsula. The information has been built up in the integrated natural barrier database system available on web (www.deepgeodisposal.kr). The database system also includes socially and economically important information, such as land use, mining area, natural conservation area, population density, and industrial complex, because some of this information is used as exclusionary criteria during the site selection process for a deep geological repository for safe and secure containment and isolation of spent nuclear fuel and other long-lived radioactive waste in Korea. Although the official site selection process has not been started yet in Korea, current integrated natural barrier database system and socio-economic database is believed that the database system will be effectively utilized to narrow down the number of sites where future investigation is most promising in the site selection process for a deep geological repository and to enhance public acceptance by providing readily-available relevant scientific information on deep geological environments in Korea. (authors)

  6. Project Guarantee 1985. Final repository for high-level radioactive wastes: The system of safety barriers

    International Nuclear Information System (INIS)

    Anon.

    1985-01-01

    Final disposal of radioactive waste involves preventing the waste from returning from the repository location into the biosphere by means of successively arranged containment measures known as safety barriers. In the present volume NGB 85-04 of the series of reports for Project 'Guarantee' 1985, the safety barrier system for the type C repository for high-level waste is described. The barrier parameters which are relevant for safety analysis are quantified and associated error limits and data scatter are given. The aim of the report is to give a summary documentation of the safety analysis input data and their scientific background. For secure containment of radioactive waste safety barriers are used which effectively limit the release of radioactive material from the repository (release barriers) and effectively retard the entry of the original radioactive material into the biosphere (time barriers). Safety barriers take the form of both technically constructed containment measures and the siting of the repository in suitable geological formations. The technical safety barrier system in the case of high-level waste comprises: the waste solidification matrix (borosilicate glass), massive steel canisters, encasement of the waste canisters, encasement of the waste canisters in highly compacted bentonite, sealing of vacant storage space and access routes on repository closure. The natural geological safety barriers - the host rock and overlying formations provide sufficiently long deep groundwater flow times from the repository location to the earth's surface and for additional lengthening of radionuclide migration times by means of various chemical and physical retardation mechanisms. The stability of the geological formations is so great that hydrogeological system is protected for a sufficient length of time from deterioration caused, in particular, by erosion. Observations in the final section of the report indicate that input data for the type C repository safety

  7. Chasing boundaries and cascade effects in a coupled barrier-marsh-lagoon system

    Science.gov (United States)

    Lorenzo-Trueba, Jorge; Mariotti, Giulio

    2017-08-01

    The long-term dynamic evolution of an idealized barrier-marsh-lagoon system experiencing sea-level rise is studied by coupling two existing numerical models. The barrier model accounts for the interaction between shoreface dynamics and overwash flux, which allows the occurrence of barrier drowning. The marsh-lagoon model includes both a backbarrier marsh and an interior marsh, and accounts for the modification of the wave regime associated with changes in lagoon width and depth. Overwash, the key process that connects the barrier shoreface with the marsh-lagoon ecosystems, is formulated to account for the role of the backbarrier marsh. Model results show that a number of factors that are not typically associated with the dynamics of coastal barriers can enhance the rate of overwash-driven landward migration by increasing backbarrier accommodation space. For instance, lagoon deepening could be triggered by marsh edge retreat and consequent export of fine sediment via tidal dispersion, as well as by an expansion of inland marshes and consequent increase in accommodation space to be filled in with sediment. A deeper lagoon results in a larger fraction of sediment overwash being subaqueous, which coupled with a slow shoreface response sending sediment onshore can trigger barrier drowning. We therefore conclude that the supply of fine sediments to the back-barrier and the dynamics of both the interior and backbarrier marsh can be essential for maintaining the barrier system under elevated rates of sea-level rise. Our results highlight the importance of considering barriers and their associated backbarriers as part of an integrated system in which sediment is exchanged.

  8. Selective evolutionary generation systems: Theory and applications

    Science.gov (United States)

    Menezes, Amor A.

    This dissertation is devoted to the problem of behavior design, which is a generalization of the standard global optimization problem: instead of generating the optimizer, the generalization produces, on the space of candidate optimizers, a probability density function referred to as the behavior. The generalization depends on a parameter, the level of selectivity, such that as this parameter tends to infinity, the behavior becomes a delta function at the location of the global optimizer. The motivation for this generalization is that traditional off-line global optimization is non-resilient and non-opportunistic. That is, traditional global optimization is unresponsive to perturbations of the objective function. On-line optimization methods that are more resilient and opportunistic than their off-line counterparts typically consist of the computationally expensive sequential repetition of off-line techniques. A novel approach to inexpensive resilience and opportunism is to utilize the theory of Selective Evolutionary Generation Systems (SECS), which sequentially and probabilistically selects a candidate optimizer based on the ratio of the fitness values of two candidates and the level of selectivity. Using time-homogeneous, irreducible, ergodic Markov chains to model a sequence of local, and hence inexpensive, dynamic transitions, this dissertation proves that such transitions result in behavior that is called rational; such behavior is desirable because it can lead to both efficient search for an optimizer as well as resilient and opportunistic behavior. The dissertation also identifies system-theoretic properties of the proposed scheme, including equilibria, their stability and their optimality. Moreover, this dissertation demonstrates that the canonical genetic algorithm with fitness proportional selection and the (1+1) evolutionary strategy are particular cases of the scheme. Applications in three areas illustrate the versatility of the SECS theory: flight

  9. Response of a thermal barrier system to acoustic excitation in a gas turbine nuclear reactor

    International Nuclear Information System (INIS)

    Betts, W.S. Jr.; Blevins, R.D.

    1980-11-01

    A gas turbine located within a High-Temperature Gas-Cooled Reactor (HTGR) induces high acoustic sound pressure levels into the primary coolant (helium). This acoustic loading induces high cycle fatigue stresses which may control the design of the thermal barrier system. This study examines the dynamic response of a thermal barrier configuration consisting of a fibrous insulation compressed against the reactor vessel by a coverplate which is held in position by a central attachment fixture. The results of dynamic vibration analyses indicate the effect of the plate size and curvature and the attachment size on the response of the thermal barrier

  10. Proxy records of Holocene storm events in coastal barrier systems: Storm-wave induced markers

    Science.gov (United States)

    Goslin, Jérôme; Clemmensen, Lars B.

    2017-10-01

    Extreme storm events in the coastal zone are one of the main forcing agents of short-term coastal system behavior. As such, storms represent a major threat to human activities concentrated along the coasts worldwide. In order to better understand the frequency of extreme events like storms, climate science must rely on longer-time records than the century-scale records of instrumental weather data. Proxy records of storm-wave or storm-wind induced activity in coastal barrier systems deposits have been widely used worldwide in recent years to document past storm events during the last millennia. This review provides a detailed state-of-the-art compilation of the proxies available from coastal barrier systems to reconstruct Holocene storm chronologies (paleotempestology). The present paper aims (I) to describe the erosional and depositional processes caused by storm-wave action in barrier and back-barrier systems (i.e. beach ridges, storm scarps and washover deposits), (ii) to understand how storm records can be extracted from barrier and back-barrier sedimentary bodies using stratigraphical, sedimentological, micro-paleontological and geochemical proxies and (iii) to show how to obtain chronological control on past storm events recorded in the sedimentary successions. The challenges that paleotempestology studies still face in the reconstruction of representative and reliable storm-chronologies using these various proxies are discussed, and future research prospects are outlined.

  11. Optimal Sensor Selection for Health Monitoring Systems

    Science.gov (United States)

    Santi, L. Michael; Sowers, T. Shane; Aguilar, Robert B.

    2005-01-01

    Sensor data are the basis for performance and health assessment of most complex systems. Careful selection and implementation of sensors is critical to enable high fidelity system health assessment. A model-based procedure that systematically selects an optimal sensor suite for overall health assessment of a designated host system is described. This procedure, termed the Systematic Sensor Selection Strategy (S4), was developed at NASA John H. Glenn Research Center in order to enhance design phase planning and preparations for in-space propulsion health management systems (HMS). Information and capabilities required to utilize the S4 approach in support of design phase development of robust health diagnostics are outlined. A merit metric that quantifies diagnostic performance and overall risk reduction potential of individual sensor suites is introduced. The conceptual foundation for this merit metric is presented and the algorithmic organization of the S4 optimization process is described. Representative results from S4 analyses of a boost stage rocket engine previously under development as part of NASA's Next Generation Launch Technology (NGLT) program are presented.

  12. Workplace barriers encountered by employed persons with systemic sclerosis.

    Science.gov (United States)

    Poole, Janet L; Anwar, Sahar; Mendelson, Cindy; Allaire, Saralynn

    2016-01-01

    Systemic sclerosis (SSc) is an auto-immune connective tissue disease characterized by fibrosis of skin, blood vessels, and internal organs that results in significant disability. To identify the work barriers faced by people with systemic sclerosis (SSc) in maintaining employment. Thirty-six people with SSc who were working more than 8 hours per week completed the Work Experience Survey, which contains lists of potential work barriers, including the ability to travel to and from work; get around at work; perform essential job functions, including physical, cognitive, and task-related activities; work with others; and manage work conditions. Thirty-three participants completed and returned the questionnaires, most of whom were female, and working full time and in professional careers. Principal disease symptoms included fatigue, Raynaud's phenomenon, esophageal involvement, and leg or hand/wrist pain. All participants reported some barriers with a mean of 18 barriers per participant. At least three quarters of participants cited outside temperature (82%), cold temperatures inside the workplace (76%), and household work (76%), as barriers. The next most common barriers were using both hands (64%), arranging and taking part in social activities (64%), being able to provide self-care (61%) and working 8 hours (58%). Participants reported a wide range of barriers, from cold temperatures, to physical job, fatigue related, and non-workplace demands, in maintaining the worker role. The barriers reflect the disease symptoms they reported. Identifying workplace barriers facilitates the creation of job accommodations or adaptations that will allow people with SSc to continue working.

  13. Investigation of endothelial growth using a sensors-integrated microfluidic system to simulate physiological barriers

    Directory of Open Access Journals (Sweden)

    Rajabi Taleieh

    2015-09-01

    Full Text Available In this paper we present a microfluidic system based on transparent biocompatible polymers with a porous membrane as substrate for various cell types which allows the simulation of various physiological barriers under continuous laminar flow conditions at distinct tunable shear rates. Besides live cell and fluorescence microscopy, integrated electrodes enable the investigation of the permeability and barrier function of the cell layer as well as their interaction with external manipulations using the Electric Cell-substrate Impedance Sensing (ECIS method.

  14. Pathways for Small Molecule Delivery to the Central Nervous System Across the Blood-Brain Barrier

    OpenAIRE

    Mikitsh, John L; Chacko, Ann-Marie

    2014-01-01

    The treatment of central nervous system (CNS) disease has long been difficult due to the ineffectiveness of drug delivery across the blood-brain barrier (BBB). This review summarizes important concepts of the BBB in normal versus pathophysiology and how this physical, enzymatic, and efflux barrier provides necessary protection to the CNS during drug delivery, and consequently treatment challenging. Small molecules account for the vast majority of available CNS drugs primarily due to their abi...

  15. System Evolution Barriers and How to Overcome Them!

    NARCIS (Netherlands)

    Borches Juzgado, P.D.; Bonnema, Gerrit Maarten; Cloutier Sauser, B.; Gill, E.

    2010-01-01

    Creating complex systems from scratch is time consuming and costly, therefore a strategy often chosen by companies is to evolve existing systems. Yet evolving a system is also complicated. Complex systems are usually the result of multidisciplinary teams, therefore it is essential to understand

  16. QUANTIFYING BARRIERS TO TRADE IN SERVICES THROUGHCOMMERCIAL PRESENCE: SELECTED SERVICES IN MALAYSIA

    Directory of Open Access Journals (Sweden)

    Nirwan Noh

    2012-07-01

    Full Text Available The services sector in Malaysia is slowlyliberalising in terms of equityownership. However, trade and investment barriers in the services sector aredifficult to measure since it is not easily quantifiable. Previous studies weremainly macro-level, multi-country cross-sectional assessments while there are nocountry level studies over time. This paper has two objectives. The first is tomeasure barriers to trade in services carried out through commercial presence(Mode 3 in Malaysia in several industries over time. The second objective is toassess the policy implications of the measurement obtained.Based on availabledata, the industries covered in this study include communications, construction,distribution, higher education, financial, healthcare, tourism and transportationand logistics services from 2001-2010.This assessment is important asMalaysiahopes to attract more foreign direct investment (FDI intoitsservices sector.Information is gathered throughsurveys, focus group discussions andcontentanalysis ofsecondary sources.Restrictive policies on FDI aretransformed intoanindex to measure the extent of liberalisation for each subsector.Based on theindex, it can be seen that theliberalisationprocessis still slow. To facilitatefurther progress inliberalising the services sector, it is important toliberalisebarriersbeyond mere equityownership.

  17. The Hybridization Barrier between Herbaceous Medicago sativa and Woody M. arborea Is Weakened by Selection of Seed Parents

    Science.gov (United States)

    Bingham, Edwin; Armour, David; Irwin, John

    2013-01-01

    Medicago sativa, alfalfa or lucerne, and M. arborea were considered reproductively isolated until recently. Then, in 2003, an alfalfa genotype was identified that produced a few seeds and progeny with hybrid traits after a large number of pollinations by M. arborea. A derivative of this alfalfa genotype also produced a low frequency of progeny with hybrid traits. Thus, the hybridization barrier was weakened by selection of seed parents. Hybrids from both events expressed traits from M. arborea and M. arborea-specific DNA bands, although more of the M. sativa genome was retained, based on the DNA results. Thus, there was chromatin elimination during embryogenesis, resulting in partial hybrids (hereafter hybrids). However, more than 30 hybrids with an array of M. arborea traits have been obtained thus far, and research continues on the nature of the hybrids. Traits have been genetically transmitted in crosses, and selected traits are in use for alfalfa breeding. This paper reviews the first hybrids and then focuses on further weakening of the hybridization barrier with the discovery of a more efficient hybridizer derived from crossing Medicago sativa subspecies, sativa, coerulea and falcata. This genotype was found to have reproductive abnormalities associated with its complex subspecies origin that are best described as hybrid breakdown. In effect, this subspecies derivative is a bridge-cross parent that consistently produces hybrids. Reproductive abnormalities in the bridge-cross parent are reported and discussed. PMID:27137379

  18. The Hybridization Barrier between Herbaceous Medicago sativa and Woody M. arborea Is Weakened by Selection of Seed Parents

    Directory of Open Access Journals (Sweden)

    Edwin Bingham

    2013-05-01

    Full Text Available Medicago sativa, alfalfa or lucerne, and M. arborea were considered reproductively isolated until recently. Then, in 2003, an alfalfa genotype was identified that produced a few seeds and progeny with hybrid traits after a large number of pollinations by M. arborea. A derivative of this alfalfa genotype also produced a low frequency of progeny with hybrid traits. Thus, the hybridization barrier was weakened by selection of seed parents. Hybrids from both events expressed traits from M. arborea and M. arborea-specific DNA bands, although more of the M. sativa genome was retained, based on the DNA results. Thus, there was chromatin elimination during embryogenesis, resulting in partial hybrids (hereafter hybrids. However, more than 30 hybrids with an array of M. arborea traits have been obtained thus far, and research continues on the nature of the hybrids. Traits have been genetically transmitted in crosses, and selected traits are in use for alfalfa breeding. This paper reviews the first hybrids and then focuses on further weakening of the hybridization barrier with the discovery of a more efficient hybridizer derived from crossing Medicago sativa subspecies, sativa, coerulea and falcata. This genotype was found to have reproductive abnormalities associated with its complex subspecies origin that are best described as hybrid breakdown. In effect, this subspecies derivative is a bridge-cross parent that consistently produces hybrids. Reproductive abnormalities in the bridge-cross parent are reported and discussed.

  19. Effect of vadose zone on the steady-state leakage rates from landfill barrier systems

    International Nuclear Information System (INIS)

    Celik, B.; Rowe, R.K.; Unlue, K.

    2009-01-01

    Leakage rates are evaluated for a landfill barrier system having a compacted clay liner (CCL) underlain by a vadose zone of variable thickness. A numerical unsaturated flow model SEEP/W is used to simulate the moisture flow regime and steady-state leakage rates for the cases of unsaturated zones with different soil types and thicknesses. The results of the simulations demonstrate that harmonic mean hydraulic conductivity of coarse textured vadose zones is 3-4 orders of magnitude less than saturated hydraulic conductivity; whereas, the difference is only one order of magnitude for fine textured vadose zones. For both coarse and fine textured vadose zones, the effective hydraulic conductivity of the barrier system and the leakage rate to an underlying aquifer increases with increasing thickness of the vadose zone and ultimately reaches an asymptotic value for a coarse textured vadose zone thickness of about 10 m and a fine textured vadose zone thickness of about 5 m. Therefore, the fine and coarse textured vadose zones thicker than about 5 m and 10 m, respectively, act as an effective part of the barrier systems examined. Although the thickness of vadose zone affects the effective hydraulic conductivity of the overall barrier system, the results demonstrated that the hydraulic conductivity of the CCL is the dominant factor controlling the steady-state leakage rates through barrier systems having single low permeability clay layers

  20. Site selection and design basis of the National Disposal Facility for LILW. Geological and engineering barriers

    International Nuclear Information System (INIS)

    Boyanov, S.

    2010-01-01

    Content of the presentation: Site selection; Characteristics of the “Radiana” site (location, geological structure, physical and mechanical properties, hydro-geological conditions); Design basis of the Disposal Facility; Migration analysis; Safety assessment approach

  1. Barriers to oral health across selected European countries and the USA.

    Science.gov (United States)

    Manski, Richard; Moeller, John

    2017-06-01

    In this review we consider oral-health access among older adults within and between the USA and various European countries with regard to possible primary financial and modifiable secondary non-financial factors. For older adults, the likelihood of using dental services has been associated, in the health literature, with a multiplicity of factors. These factors are traditionally classified into predisposing, enabling and need categories, and can be further classified into modifiable and non-modifiable subcategories. This raises the question of which single factor or group of factors has the most influence in keeping older adults from seeking care, and how these influences might differ between the USA and various other (European) countries. As it turns out, there is variation in the magnitude of effects across certain measurable potential barriers, but generally it takes a combination of characteristics associated with non-use to have a substantial impact. © 2017 FDI World Dental Federation.

  2. Manufacture and test of prototype water pipe chase barrier in ITER Magnet Feeder system

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Kun, E-mail: lukun@ipp.ac.cn [Institute of Plasma Physics, Shushan Hu Road 350, Hefei, Anhui (China); Wen, Xinjie; Liu, Chen; Song, Yuntao [Institute of Plasma Physics, Shushan Hu Road 350, Hefei, Anhui (China); Niu, Erwu [ITER China, 15B Fuxing Road, Beijing 100862 (China); Gung, Chenyu; Su, Man [ITER Organization, Route de Vinon-sur-Verdon – CS 90046, 13067 St Paul-lez-Durance Cedex (France)

    2016-11-01

    The Magnet Feeder system in the International Thermonuclear Experimental Reactor (ITER) deploys electrical currents and supercritical helium to the superconducting magnets and the magnet diagnostic signals to the operators. In the current design, the feeders located in the upper L3 level of the Tokamak gallery penetrate the Tokamak coolant water system vault, the biological shield and the cryostat. As a secondary confinement to contain the activated coolant water in the vault in the case of water pipe burst accident, a water barrier is welded between the penetration in the water pipe chase outer wall and the mid-plane of the vacuum jacket of the Feeder Coil Terminal Box (CTB). A thin-wall stainless steel diaphragm with an omega shape profile is welded around the CTB as the water barrier to endure 2 bar hydraulic pressure. In addition, the barrier is designed as a flexible compensator to withstand a maximum of 15 mm of axial displacement of the CTB in case of helium leak accident without failure. This paper presents the detail configuration, the manufacturing and assembly processes of the water barrier. Test results of the prototype water barrier under simulated accident conditions are also reported. Successful qualification of the design and manufacturing process of the water barrier lays a good foundation for the series production of this subsystem.

  3. Facilitators and Barriers of Implementing a Measurement Feedback System in Public Youth Mental Health.

    Science.gov (United States)

    Kotte, Amelia; Hill, Kaitlin A; Mah, Albert C; Korathu-Larson, Priya A; Au, Janelle R; Izmirian, Sonia; Keir, Scott S; Nakamura, Brad J; Higa-McMillan, Charmaine K

    2016-11-01

    This study examines implementation facilitators and barriers of a statewide roll-out of a measurement feedback system (MFS) in a youth public mental health system. 76 % of all state care coordinators (N = 47) completed interviews, which were coded via content analysis until saturation. Facilitators (e.g., recognition of the MFS's clinical utility) and barriers (e.g., MFS's reliability and validity) emerged paralleling the Exploration, Adoption/Preparation, Implementation, and Sustainment framework outlined by Aarons et al. (Adm Policy Mental Health Mental Health Serv Res, 38:4-23, 2011). Sustainment efforts may leverage innovation fit, individual adopter, and system related facilitators.

  4. Sub-barrier fusion and transfers in the 40Ca + 58,64Ni systems

    Science.gov (United States)

    Bourgin, D.; Courtin, S.; Haas, F.; Goasduff, A.; Stefanini, A. M.; Montagnoli, G.; Montanari, D.; Corradi, L.; Huiming, J.; Scarlassara, F.; Fioretto, E.; Simenel, C.; Rowley, N.; Szilner, S.; Mijatović, T.

    2016-05-01

    Fusion cross sections have been measured in the 40Ca + 58Ni and 40Ca + 64Ni systems at energies around and below the Coulomb barrier. The 40Ca beam was delivered by the XTU Tandem accelerator of the Laboratori Nazionali di Legnaro and evaporation residues were measured at very forward angles with the LNL electrostatic beam deflector. Coupled-channels calculations were performed which highlight possible strong effects of neutron transfers on the fusion below the barrier in the 40Ca + 64Ni system. Microscopic time-dependent Hartree-Fock calculations have also been performed for both systems. Preliminary results are shown.

  5. Sub-barrier fusion and transfers in the 40Ca + 58,64Ni systems

    Directory of Open Access Journals (Sweden)

    Bourgin D.

    2016-01-01

    Full Text Available Fusion cross sections have been measured in the 40Ca + 58Ni and 40Ca + 64Ni systems at energies around and below the Coulomb barrier. The 40Ca beam was delivered by the XTU Tandem accelerator of the Laboratori Nazionali di Legnaro and evaporation residues were measured at very forward angles with the LNL electrostatic beam deflector. Coupled-channels calculations were performed which highlight possible strong effects of neutron transfers on the fusion below the barrier in the 40Ca + 64Ni system. Microscopic time-dependent Hartree-Fock calculations have also been performed for both systems. Preliminary results are shown.

  6. Fusion and particle transfer around the Coulomb-Barrier in intermediate systems

    International Nuclear Information System (INIS)

    Pascholati, P.R.

    1989-01-01

    The most important characteristics of fusion reactions below and around the Coulomb-barrier are summarized. Experimental fusion cross sections for typical systems are discussed and compared with current formulae obtained from semi-classical and quantum tunneling approaches. The influence of nucleons transfer in the enhancement of the fusion cross section below the Coulomb-barrier is also shown. Sub-barrier fusion cross sections for the systems 35,37 Cl + 58,64 Ni and 33 S + 90,91,92 Zr, and near-barrier cross sections of all important transfer channels have been measured using the XTU-TANDEM at Legnaro, Italy. In 35,37 Cl + 58,64 Ni systems, the motivation further investigated was the influence of the valence proton in the enhancement of the sub-barrier fusion cross section. The data are discussed in comparison with the similar data of 34,36 S + 58,64 Ni with the aim of revealing the influence of coupled proton transfer channels. Calculations were performed using the simplified coupled channel code CCFUS including ''pick-up'' of one and two neutrons and ''stripping'' of two neutrons channels. Signatures of positive Q-values transfer channels coupled to fusion were clearly identified. For the 33 S + 90,91,92 Zr systems taking into account the coupling effects between transfer and fusion and using the semi-classical approach, transfer form-factors were extracted and succesfully employed to described the isotopic effects in fusion enhancement. (Author) [es

  7. Impact of vertical barriers on performance of pump-and-treat systems

    International Nuclear Information System (INIS)

    Russell, K.; Rabideau, A.

    1997-01-01

    Although aquifer remediation by Pump-and-treat (PAT) is widely practiced, it is generally implemented as an effective means of plume containment, rather than as an efficient means of contaminant mass removal. The use of slurry cutoff walls has been recognized as a means of improving the performance of PAT with respect to hydraulic control. As part of a study on the use of decision analysis in the design of aquifer remediation systems, the economic tradeoffs between capital costs and risk reduction were compared for several alternative PAT strategies. This work included an evaluation of the use of vertical barriers as components of PAT systems, using numerical experiments to examine the impacts of vertical barriers on PAT reliability. The results indicated that the use of vertical barriers in conjunction with PAT can significantly improve the simulated system performance, but that the magnitude of the predicted enhancement and cost-effectiveness of the barrier system are dependent on site characteristics, barrier placement, and modeling assumptions

  8. Effect of joint mechanism on vehicle redirectional capability of water-filled road safety barrier systems.

    Science.gov (United States)

    Thiyahuddin, M I; Thambiratnam, D P; Gu, Y T

    2014-10-01

    Portable water-filled barriers (PWFBs) are roadside appurtenances that prevent vehicles from penetrating into temporary construction zones on roadways. PWFBs are required to satisfy the strict regulations for vehicle re-direction in tests. However, many of the current PWFBs fail to re-direct the vehicle at high speeds due to the inability of the joints to provide appropriate stiffness. The joint mechanism hence plays a crucial role in the performance of a PWFB system at high speed impacts. This paper investigates the desired features of the joint mechanism in a PWFB system that can re-direct vehicles at high speeds, while limiting the lateral displacement to acceptable limits. A rectangular "wall" representative of a 30m long barrier system was modeled and a novel method of joining adjacent road barriers was introduced through appropriate pin-joint connections. The impact response of the barrier "wall" and the vehicle was obtained and the results show that a rotational stiffness of 3000kNm/rad at the joints seems to provide the desired features of the PWFB system to re-direct impacting vehicles and restrict the lateral deflection. These research findings will be useful to safety engineers and road barrier designers in developing a new generation of PWFBs for increased road safety. Copyright © 2014 Elsevier Ltd. All rights reserved.

  9. Comparative Analysis of AHP-TOPSIS and Fuzzy AHP Models in Selecting Appropriate Nanocomposites for Environmental Noise Barrier Applications

    Science.gov (United States)

    Naderzadeh, Mahdiyeh; Arabalibeik, Hossein; Monazzam, Mohammad Reza; Ghasemi, Ismaeil

    Choosing the right material in the design of environmental noise barriers has always been a challenging issue in acoustics. In less-developed countries, the material selection is affected by many factors from various aspects, which makes the decision-making very complicated. This study attempts to compare and assign weights to the most important indices affecting the choice of appropriate noise barrier material. These criteria include absorption coefficient, transparency, tensile modulus, strength at yield, elongation at break, impact strength, flexural modulus, hardness, and cost. For this purpose, experts' opinions was gathered through a total of 13 questionnaires and used for assigning weights by Analytic Hierarchy Process (AHP) and Fuzzy Analytic Hierarchy process (FAHP) techniques. According to the AHP results, impact strength, with only a minor difference of 0.093 compared to the AHP, was recognized as the most important criterion. Finally, the optimal composite material was selected using two different methods; first by Technique for Order-Preference by Similarity to Ideal Solution (TOPSIS) based on the weights obtained from AHP, and next by directly applying the obtained weights from FAHP to the true measured values of parameters. As the results show, in both abovementioned methods, Polycarbonate-SiO2 0.3% with roughened surface (PCSI3-R) received the highest score and was selected as the preferred composite material. Given the close similarity of the results, to determine the superiority of one method over the other, some noise was added to the original data set from the mechanical and acoustic tests and then the variance of the changes in the final orders of preferences was calculated. This indicates the robustness of the method against the measurement errors and noise. The results shows that under the same circumstances, the overall order shift variance in the classic TOPSIS is six times higher than that of the fuzzy AHP method.

  10. Quantitative performance allocation of multi-barrier system for high-level radioactive waste disposal

    International Nuclear Information System (INIS)

    Ahn, Joon-Hong; Ikeda, Takao; Ohe, Toshiaki

    1995-01-01

    Performance assessment of each barrier consisting of geologic disposal system for high-level radioactive wastes is carried out quantitatively, and key radionuclides and parameters are pointed out. Chemical compositions and solubilities of radionuclides under repository conditions are determined by PHREEQE code staring from compositions of granitic groundwater observed in Japan. Glass dissolution analysis based on mass transfer theory and precipitation analysis have been done in order to determine the inner boundary condition for radionuclide diffusion through a bentonite-filled buffer region, where multi-member decay chain and isotopic sharing of solubility at the inner boundary are considered. Natural barrier is treated as homogeneous porous rock, or porous rock with infinite planar fractures. Performance of each barrier is evaluated in terms of non-dimensionalized hazard defined as the ratio of annual radioactivity release from each barrier to the annual limit on intake. At the outer edge of the engineered barriers, 239 Pu is the key unclide to the performance, whereas at the exit of the natural barrier, weakly-sorbing fission product nuclides such as 135 Cs, 129 I and 99 Tc dominate the hazard. (author) 50 refs

  11. Modeling the Hydrogeochemical Transport of Radionuclides through Engineered Barriers System in the Proposed LLW Disposal Site of Taiwan - 12082

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Wen-Sheng [Hydrotech Research Institute, National Taiwan University, Taipei, Taiwan (China); Liu, Chen-Wuing; Tsao, Jui-Hsuan [Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan (China); Li, Ming-Hsu [Institute of Hydrological and Oceanic Sciences, National Central University, Jhongli, Taiwan (China)

    2012-07-01

    A proposed site for final disposal of low-level radioactive waste located in Daren Township of Taitung County along the southeastern coast has been on the selected list in Taiwan. The geology of the Daren site consists of argillite and meta-sedimentary rocks. A mined cavern design with a tunnel system of 500 m below the surface is proposed. Concrete is used as the main confinement material for the engineered barrier. To investigate the hydrogeochemical transport of radionuclides through engineered barriers system, HYDROGEOCHEM5.0 model was applied to simulate the complex chemical interactions among radionuclides, the cement minerals of the concrete, groundwater flow, and transport in the proposed site. The simulation results showed that the engineered barriers system with the side ditch efficiently drained the ground water and lowered the concentration of the concrete degradation induced species (e.g., hydrogen ion, sulfate, and chloride). The velocity of groundwater observed at side ditch gradually decreased with time due to the fouling of pore space by the mineral formation of ettringite and thaumasite. The short half-life of Co-60, Sr-90 and Cs-137 significantly reduced the concentrations, whereas the long half-life of I-129(1.57x10{sup 7} years) and Am-241(432 years) remain stable concentrations at the interface of waste canister and concrete barrier after 300 years. The mineral saturation index (SI) was much less than zero due to the low aqueous concentration of radionuclide, so that the precipitation formation of Co-60, Sr-90, I-129, Cs-137 and Am-241 related minerals were not found. The effect of adsorption/desorption (i.e., surface complexation model) could be a crucial geochemical mechanism for the modeling of liquid-solid phase behavior of radionuclide in geochemically dynamic environments. Moreover, the development of advanced numerical models that are coupled with hydrogeochemical transport and dose assessment of radionuclide is required in the future

  12. Exploration of Scholars’ Attributions of Instructional Barriers in the Context of Pedagogical-Epistemological Belief Systems

    Directory of Open Access Journals (Sweden)

    Yılmaz SOYSAL

    2017-08-01

    Full Text Available In this study, two academics’ who have been employed in a private university teaching barriers and accompanied attributional reasoning were examined in the context of their belief systems with regards to learning, teaching and knowledge. This study was conducted with a basic qualitative perspective. By means of qualitative data gathering and analysis, it was aimed at estimating how the relation between teaching barriers and attributional reasoning was influenced by pedagogical-epistemological belief systems of scholars. Qualitative data was collected through two different semi-structured interview protocols and gathered data was analyzed with an inductive and interpretivist manner. The scholars’ beliefs systems’ divergences (teacher-centered vs. learner-centered allowed to explore the presumable relation of barrier-attribution in the context of pedagogical-epistemological belief systems. It was found out that the scholar who has adopted the more learner-centered modes of teaching favors more internally-oriented, controllable and non-stable attributional styles in illustrating her barrier-attribution relation. In contrast, it was also detected that the scholar who has held more teacher-centered teaching beliefs is liable to make attributions to overly external, non-controllable and stable factors in illuminating her barrier-attribution relation. Major outcomes of the study are evaluated by means of psychological (i.e., attribution theory and instructional (pedagogical-epistemological beliefs lenses and suggestions are offered in the context of higher education.

  13. Barrier and system performances within a safety case: their functioning and evolution with time

    International Nuclear Information System (INIS)

    Hedin, A.; Voinis, S.; Fillion, E.; Keller, S.; Lalieux, Ph.; Nachmilner, L.; Nys, V.; Rodriguez, J.; Sevougian, D.; Wollrath, J.

    2002-01-01

    The following six questions were used as the basis for the discussions in a Working Group: - What is the role of each barrier as a function of time or in the different time frames? What is its contribution to the overall system performance or safety as a function of time? - Which are the main uncertainties on the performance of barriers in the timescales? To what extent should we enhance the robustness of barriers because of the uncertainties of some component behaviour with time? - What is the requested or required performance versus the expected realistic or conservative behaviour with time? How are these safety margins used as arguments in a safety case? - What is the issue associated with the geosphere stability for different geological systems? - How are barriers and system performances, as a function of time, evaluated (presented and communicated) in a safety case? - What kind of measures are used for siting, designing and optimising robust barriers corresponding to situations that can vary with time? Are human actions considered to be relevant? (authors)

  14. Socio-cultural barriers to the development of a sustainable energy system - the case of hydrogen

    DEFF Research Database (Denmark)

    Petersen, Lars Kjerulf; Andersen, Anne Holst

    Any transition to a more sustainable energy system, radically reducing greenhouse gas emissions, is bound to run in to a host of different barriers - technological and economic, but also socio-cultural. This will also be the case for any large-scale application of hydrogen as energy carrier......, especially if the system is going to be based on renewable energy sources. The aim of these research notes is to review and discuss major socio-cultural barriers to new forms of energy supply in general and to hydrogen specifically. Reaching sufficient reductions in greenhouse gas emissions may require more...

  15. Numerical evaluation of energy barriers and magnetic relaxation in interacting nanostructured magnetic systems

    International Nuclear Information System (INIS)

    Chubykalo-Fesenko, Oksana A.; Chantrell, Roy W.

    2004-01-01

    We discuss a model to quantify long-time thermally induced magnetization reversal in magnetic systems with distributed properties. Two algorithms, based on kinetic and Metropolis Monte Carlo are introduced. While the former requires the constant recalculation of all energy barriers and is useful when the interactions are weak, the latter uses the Metropolis Monte Carlo to estimate the magnetization trajectory and, consequently, only the most probable transition rates are evaluated. The ridge optimization method is used to evaluate the energy barriers in a multidimensional energy landscape. The algorithms are applied to a granular system modeled by means of Voronoi polyhedra and having random in-plane anisotropy

  16. Engineered barrier systems (EBS) in the context of the entire safety case

    International Nuclear Information System (INIS)

    2003-01-01

    A joint NEA-EC workshop entitled 'Engineered Barrier Systems (EBS) in the Context of the Entire Safety Case' was organised in Oxford on 25-27 September 2002 and hosted by United Kingdom Nirex Limited. The main objectives of the workshop were to provide a status report on engineered barrier systems in various national radioactive waste management programmes considering deep geological disposal; to establish the value to member countries of a project on EBS; and to define such a project's scope, timetable and modus operandi. This report presents the outcomes of this workshop. (author)

  17. Engineered Barrier Systems (EBS) in the Context of the Entire Safety Case

    International Nuclear Information System (INIS)

    2005-01-01

    A joint NEA-EC workshop entitled ''Engineered Barrier Systems (EBS) in the Context of the Entire Safety Case'' was organised in Oxford on 25-27 September 2002 and hosted by United Kingdom Nirex Limited. The main objectives of the workshop were to provide a status report on engineered barrier systems in various national radioactive waste management programmes considering deep geological disposal; to establish the value to member countries of a project on EBS; and to define such a project scope, timetable and modus operandi. This report presents the outcomes of this workshop. (author)

  18. Supplier Selection Using Fuzzy Inference System

    Directory of Open Access Journals (Sweden)

    hamidreza kadhodazadeh

    2014-01-01

    Full Text Available Suppliers are one of the most vital parts of supply chain whose operation has significant indirect effect on customer satisfaction. Since customer's expectations from organization are different, organizations should consider different standards, respectively. There are many researches in this field using different standards and methods in recent years. The purpose of this study is to propose an approach for choosing a supplier in a food manufacturing company considering cost, quality, service, type of relationship and structure standards of the supplier organization. To evaluate supplier according to the above standards, the fuzzy inference system has been used. Input data of this system includes supplier's score in any standard that is achieved by AHP approach and the output is final score of each supplier. Finally, a supplier has been selected that although is not the best in price and quality, has achieved good score in all of the standards.

  19. Effect of inter-species selective interactions on the thermodynamics and nucleation free-energy barriers of a tessellating polyhedral compound

    International Nuclear Information System (INIS)

    Escobedo, Fernando A.

    2016-01-01

    The phase behavior and the homogeneous nucleation of an equimolar mixture of octahedra and cuboctahedra are studied using thermodynamic integration, Gibbs-Duhem integration, and umbrella sampling simulations. The components of this mixture are modeled as polybead objects of equal edge lengths so that they can assemble into a space-filling compound with the CsCl crystal structure. Taking as reference the hard-core system where the compound crystal does not spontaneously nucleate, we quantified the effect of inter-species selective interactions on facilitating the disorder-to-order transition. Facet selective and facet non-selective inter-species attractions were considered, and while the former was expectedly more favorable toward the target tessellating structure, the latter was found to be similarly effective in nucleating the crystal compound. Ranges for the strength of attractions and degree of supersaturation were identified where the nucleation free-energy barrier was small enough to foretell a fast process but large enough to prevent spinodal fluctuations that can trap the system in dense metastable states lacking long-range order. At those favorable conditions, the tendency toward the local orientational order favored by packing entropy is amplified and found to play a key role seeding nuclei with the CsCl structure.

  20. An in vitro and in vivo study of peptide-functionalized nanoparticles for brain targeting : The importance of selective blood–brain barrier uptake

    NARCIS (Netherlands)

    Bode, Gerard H.; Coué, G.M.J.P.C.; Freese, Christian; Pickl, Karin E.; Sanchez-Purrà, Maria; Albaiges, Berta; Borrós, Salvador; van Winden, Ewoud C.; Tziveleka, Leto Aikaterini; Sideratou, Zili; Engbersen, Johan F.J.; Singh, Smriti; Albrecht, Krystyna; Groll, Jürgen; Möller, Martin; Pötgens, Andy J.G.; Schmitz, Christoph; Fröhlich, Eleonore; Grandfils, Christian; Sinner, Frank M.; Kirkpatrick, C. James; Steinbusch, Harry W.M.; Frank, Hans Georg; Unger, Ronald E.; Martinez-Martinez, Pilar

    2017-01-01

    Targeted delivery of drugs across endothelial barriers remains a formidable challenge, especially in the case of the brain, where the blood–brain barrier severely limits entry of drugs into the central nervous system. Nanoparticle-mediated transport of peptide/protein-based drugs across endothelial

  1. A novel muscarinic receptor ligand which penetrates the blood brain barrier and displays in vivo selectivity for the m2 subtype

    International Nuclear Information System (INIS)

    Gitler, M.S.; Cohen, V.I.; De La Cruz, R.; Boulay, S.F.; Jin, B.; Zeeberg, B.R.; Reba, R.C.

    1993-01-01

    Alzheimer's disease (AD) involves selective loss of muscarinic m2, but not m1, subtype neuroreceptors in the posterior parietal cortex of the human brain. Emission tomographic study of the loss of m2 receptors in AD is limited by the fact that there is currently no available m2-selective radioligand which can penetrate the blood-brain barrier. In our efforts to prepare such a radioligand, the authors have used competition studies against currently existing muscarinic receptor radioligands to infer the in vitro and in vivo properties of a novel muscarinic receptor ligand, 5-[[4-[4-(diisobutylamino)butyl]-1-phenyl]acetyl]-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-11-one (DIBD). In vitro competition studies against [ 3 H](R)-3-quinuclidinylbenzilate ([ 3 H]QNB) and [ 3 H]N-methylscopolamine ([ 3 H]NMS), using membranes derived from transfected cells expressing only m1, m2, m3, or m4 receptor subtypes, indicate that DIBD is selective for m2/m4 over m1/m3. In vivo competition studies against (R,R)-[ 125 I]IQNB indicate that DIBD crosses the blood brain barrier (BBB). The relationship of the regional percentage decrease in (R,R)-[ 125 I]IQNB versus the percentage of each of the receptor subtypes indicates that DIBD competes more effectively in those brain regions which are known to be enriched in the m2, relative to the m1, m3, and m4, receptor subtype; however, analysis of the data using a mathematical model shows that caution is required when interpreting the in vivo results. The authors conclude that a suitably radiolabeled derivative of DIBD may be of potential use in emission tomographic study of changes in m2 receptors in the central nervous system

  2. Water removal from a dry barrier cover system

    International Nuclear Information System (INIS)

    Stormont, J.C.; Ankeny, M.D.; Tansey, M.K.

    1994-01-01

    The results of the numerical simulations reveal that horizontal air flow through the coarse with reasonable pressure gradients can remove large quantities of water from the cover system. Initially, the water removal from the cover system is dominated by the evaporation and advection of water vapor out of the coarse layer. Once the coarse layer is dry, removal of water by evaporation near the fine/coarse layer interface reduces the local water content and water potential, and water moves toward the fine-coarse layer interface and becomes available for evaporation. This result is important in that it suggests the fine layer water content may be moderated by air flow in the coarse layer. Incorporating diffusion of water vapor from the fine layer into the coarse layer substantially increases the water movement out of the fine layer

  3. Investigations on retention effects in barrier system rocks

    International Nuclear Information System (INIS)

    Memmert, G.

    1989-01-01

    A surface complex model is described for Sr, Ni and U, which is based on the measurement of cation exchange capacity, groundwater analysis and absorption experiments on sediment/groundwater systems from the Gorleben rocks. The results of through column and shaking experiments are shown. The data on absorption of Tc were reviewed. The research project was carried out together with the EEC CHEMVAL/MIRAGE project. (DG) [de

  4. Protective barrier development: Overview

    International Nuclear Information System (INIS)

    Wing, N.R.; Gee, G.W.

    1990-01-01

    Protective barrier and warning marker systems are being developed to isolate wastes disposed of near the earth's surface at the Hanford Site. The barrier is designed to function in an arid to semiarid climate, to limit infiltration and percolation of water through the waste zone to near-zero, to be maintenance free, and to last up to 10,000 yr. Natural materials (e.g., fine soil, sand, gravel, riprap, clay, asphalt) have been selected to optimize barrier performance and longevity and to create an integrated structure with redundant features. These materials isolate wastes by limiting water drainage; reducing the likelihood of plant, animal, and human intrusion; controlling emission of noxious gases; and minimizing erosion. Westinghouse Hanford Company and Pacific Northwest Laboratory efforts to assess the performance of various barrier and marker designs will be discussed

  5. Organizational, interface, and financial barriers to the commercial development of community energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Schladale, R.; Ritschard, R.

    1979-12-01

    The scope of this analysis was limited to systems producing electricity - the output of a community energy system typically falling in the range 10 kW to 150 MW. The purpose of this study was to identify the barriers that groups and individuals will face when attempting to commercialize community energy systems. Three particular classes of barriers were investigated: those within the organization attempting the commercialization, those that arise from attempts to link the community system with an electric utility, and those that impede the flow of investment capital into community energy systems. In summary, three general observations regarding community energy systems may be distilled from this study. First, although many barriers exist to the commercialization of the systems, few if any appear unresolvable. Perhaps most challenginng will be the problem of expanding the use of cogeneration and municipal sold waste while at the same time maintaining or improving ambient air quality. Second, the financial subsidies required to make community systems competitive are not extraordinary. Indeed, with the exception of photovoltaics they should not amount to more than about 10% of capital cost of the new systems, and mass production may eliminate the need for subsidies altogether at some point in the future. Third, the administrative and regulatory procedures required to make community energy systems viable appear to be taking shape in a positive and timely fashion.

  6. Engineered Barrier System - Manufacturing, Testing and Quality Assurance. Report from a Workshop

    International Nuclear Information System (INIS)

    2004-06-01

    As part of preparations for review of future license applications, the Swedish Nuclear Power Inspectorate (SKI) organised a workshop on the engineered barrier system for the KBS-3 concept, with the focus on manufacturing, testing and quality assurance. The main purpose of the workshop was to identify critical issues in the demonstration of how long-term safety requirements could be fulfilled for the engineered barriers. The workshop included presentations related to engineered barrier manufacturing and testing held by external experts, and working group sessions to prepare questions to the Swedish Nuclear Fuel and Waste Management Co. (SKB). SKB presentations were followed by an informal questioning and discussion with SKB representatives. This report includes a presentation of the questions posed by the working groups, SKB's replies to these questions as well as a summary of the working group discussions. The conclusions and viewpoints presented in this report are those of one or several workshop participants. During the workshop many issues regarding manufacturing, testing and quality assurance of the engineered barriers were discussed. The central themes in the questions and discussions are summarised as follows: There is a need to specify how the functional requirements for the buffer and backfill will be achieved in practise. Issues of particular interest are material selection, compaction density, initial water content and manufacturing methods for bentonite blocks. A major problem that must be addressed is the long period required to obtain relevant results from large-scale testing. The uncertainties relating to the wetting and subsequent swelling processes of the bentonite buffer have implications for analysis of the canister. It is necessary to know now non-uniform the bentonite swelling pressure could be in a worst case pressure differential, in order to evaluate the sufficiency of 'as tested' canister performance. Regarding the copper shell of the

  7. Investigating the Potential Barrier Function of Nanostructured Materials Formed in Engineered Barrier Systems (EBS) Designed for Nuclear Waste Isolation.

    Science.gov (United States)

    Cuevas, Jaime; Ruiz, Ana Isabel; Fernández, Raúl

    2018-02-21

    Clay and cement are known nano-colloids originating from natural processes or traditional materials technology. Currently, they are used together as part of the engineered barrier system (EBS) to isolate high-level nuclear waste (HLW) metallic containers in deep geological repositories (DGR). The EBS should prevent radionuclide (RN) migration into the biosphere until the canisters fail, which is not expected for approximately 10 3  years. The interactions of cementitious materials with bentonite swelling clay have been the scope of our research team at the Autonomous University of Madrid (UAM) with participation in several European Union (EU) projects from 1998 up to now. Here, we describe the mineral and chemical nature and microstructure of the alteration rim generated by the contact between concrete and bentonite. Its ability to buffer the surrounding chemical environment may have potential for further protection against RN migration. © 2018 The Chemical Society of Japan & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Breaking the color barrier - a multi-selective antibody reporter offers innovative strategies of fluorescence detection.

    Science.gov (United States)

    Gallo, Eugenio; Jarvik, Jonathan W

    2017-08-01

    A novel bi-partite fluorescence platform exploits the high affinity and selectivity of antibody scaffolds to capture and activate small-molecule fluorogens. In this report, we investigated the property of multi-selectivity activation by a single antibody against diverse cyanine family fluorogens. Our fluorescence screen identified three cell-impermeant fluorogens, each with unique emission spectra (blue, green and red) and nanomolar affinities. Most importantly, as a protein fusion tag to G-protein-coupled receptors, the antibody biosensor retained full activity - displaying bright fluorogen signals with minimal background on live cells. Because fluorogen-activating antibodies interact with their target ligands via non-covalent interactions, we were able to perform advanced multi-color detection strategies on live cells, previously difficult or impossible with conventional reporters. We found that by fine-tuning the concentrations of the different color fluorogen molecules in solution, a user may interchange the fluorescence signal (onset versus offset), execute real-time signal exchange via fluorogen competition, measure multi-channel fluorescence via co-labeling, and assess real-time cell surface receptor traffic via pulse-chase experiments. Thus, here we inform of an innovative reporter technology based on tri-color signal that allows user-defined fluorescence tuning in live-cell applications. © 2017. Published by The Company of Biologists Ltd.

  9. Unsupervised Calculation of Free Energy Barriers in Large Crystalline Systems

    Science.gov (United States)

    Swinburne, Thomas D.; Marinica, Mihai-Cosmin

    2018-03-01

    The calculation of free energy differences for thermally activated mechanisms in the solid state are routinely hindered by the inability to define a set of collective variable functions that accurately describe the mechanism under study. Even when possible, the requirement of descriptors for each mechanism under study prevents implementation of free energy calculations in the growing range of automated material simulation schemes. We provide a solution, deriving a path-based, exact expression for free energy differences in the solid state which does not require a converged reaction pathway, collective variable functions, Gram matrix evaluations, or probability flux-based estimators. The generality and efficiency of our method is demonstrated on a complex transformation of C 15 interstitial defects in iron and double kink nucleation on a screw dislocation in tungsten, the latter system consisting of more than 120 000 atoms. Both cases exhibit significant anharmonicity under experimentally relevant temperatures.

  10. The EC/NEA engineered barrier systems project

    International Nuclear Information System (INIS)

    Umeki, Hiroyuki; Forinash, Elizabeth K.; Davies, Christophe; Bennett, David; Hooper, Alan; Van Luik, Abe; Voinis, Sylvie

    2008-01-01

    This paper presents examples from various disposal programmes and discusses lessons that may be drawn relating to disposal system design and the use of underground tests. Many useful large-scale experiments have been conducted in underground laboratories that have allowed an assessment of the feasibility of methods for tunnel construction, waste package emplacement, buffer and backfill emplacement, tunnel seal construction, etc. In general, these tests have been successful and have shown that the necessary techniques for manufacturing and installing EBS components are feasible and available. In some cases, tests have shown that designs or techniques need to be adjusted, or have enabled identification of the factors to be taken into account in future optimisation studies. Further trials of some methods are still required, particularly at the repository or industrial scale. Further experiments are also likely to be required to increase understanding of the long-term behaviour of the EBS after installation. (author)

  11. Selection of fluids for tritium pumping systems

    International Nuclear Information System (INIS)

    Chastagner, P.

    1984-02-01

    The degradation characteristics of three types of vacuum pump fluids, polyphenyl ethers, perfluoropolyethers and hydrocarbon oils were reviewed. Fluid selection proved to be a critical factor in the long-term performance of tritium pumping systems and subsequent tritium recovery operations. Thermal degradation and tritium radiolysis of pump fluids produce contaminants which can damage equipment and interfere with tritium recovery operations. General characteristics of these fluids are as follows: polyphenyl ether has outstanding radiation resistance, is very stable under normal diffusion pump conditions, but breaks down in the presence of oxygen at anticipated operating temperatures. Perfluoropolyether fluids are very stable and do not react chemically with most gases. Thermal and mechanical degradation products are inert, but the radiolysis products are very corrosive. Most of the degradation products of hydrogen oils are volatile and the principal radiolysis product is methane. Our studies show that polyphenyl ethers and hydrocarbon oils are the preferred fluids for use in tritium pumping systems. No corrosive materials are formed and most of the degradation products can be removed with suitable filter systems

  12. New cooling system of the FRG-1 two barrier system of the primary coolant cycle

    International Nuclear Information System (INIS)

    Knop, W.; Schreiner, P.

    2003-01-01

    The GKSS research center operates the swimming pool reactor FRG-1 with a thermal power of 5 MW as national neutron source for neutron scattering experiments and sample irradiation as well. Before changing the primary coolant cycle consisted of the reactor core and the closed piping including pumps, heat exchanger and delay tank. The closed cooling circuit was located underneath the reactor pool, in the so-called radioactive cellar. This piping system served secondary coolant system. Due to the location of the primary coolant cycle below the operation pool a postulated 2-F line break and simultaneous failure of the pool slide gate valve could lead to a falling dry of the total reactor core. the new primary coolant system was built in the beginning 2002 in a partitioned cell all within the radioactive cellar, so that the reactor core remains with water with the assumed incident. Due to the new two barrier-inclusion of the primary circuit only the melting of two fuel plates (from total 252 fuel plates) has to be taken into account. This measure and the core compactness in 2000 with a neutron flux gain of a factor of 2 makes the FRG-1 ready for the next 15 years of reactor operation. (author)

  13. Measurement of interfacial shear mechanical properties in thermal barrier coating systems by a barb pullout method

    International Nuclear Information System (INIS)

    Guo, S.Q.; Mumm, D.R.; Karlsson, A.M.; Kagawa, Y.

    2005-01-01

    A test technique has been developed to facilitate evaluation of the fracture characteristics of coatings and interfaces in thermal barrier coating (TBC) systems. The methodology has particular application in analyzing delamination crack growth, where crack propagation occurs under predominantly mode II loading. The technique has been demonstrated by quantitatively measuring the effective delamination fracture resistance of an electron-beam physical vapor deposition TBC

  14. Nuclear reactions of the system 6 Li on 58 Ni near the Coulomb barrier

    International Nuclear Information System (INIS)

    Lizcano, D.; Aguilera, E.F.; Garcia M, H.; Martinez Q, E.

    2004-01-01

    Protons, alpha particles and deuterons coming from the reactions 6 Li + 58 Ni are detected to three different energy around the Coulomb barrier. The possible effects of the weakly bound character of the projectile are studied and the results are compared with previous data for the system 6 Li + 59 Co. (Author)

  15. An Activity Theory Approach to Analyze Barriers to a Virtual Management Information Systems (MIS) Curriculum

    Science.gov (United States)

    Jaradat, Suhair; Qablan, Ahmad; Barham, Areej

    2011-01-01

    This paper explains how the activity theory is used as a framework to analyze the barriers to a virtual Management Information Stream (MIS) Curriculum in Jordanian schools, from both the sociocultural and pedagogical perspectives. Taking the activity system as a unit of analysis, this study documents the processes by which activities shape and are…

  16. Barriers to installing innovative energy systems in existing housing stock identified

    NARCIS (Netherlands)

    Hoppe, Thomas

    2013-01-01

    Several barriers to upgrading existing social housing with innovative energy systems (IES) have been identified by a study of eight large-scale renovation projects in the Netherlands. These include a lack of trust between stakeholders, opposition from tenants on grounds of increased costs or delays,

  17. Underutilization of Mental Health Services among College Students: An Examination of System-Related Barriers

    Science.gov (United States)

    Marsh, Carey N.; Wilcoxon, S. Allen

    2015-01-01

    Despite the documented benefits of counseling and mental health services on academic performance and degree attainment, only about 10% of psychologically distressed college students ever seek professional help. This investigation examined mental health care system-related barriers that might distinguish help seekers from nonhelp seekers among…

  18. Process for Selecting System Level Assessments for Human System Technologies

    Science.gov (United States)

    Watts, James; Park, John

    2006-01-01

    The integration of many life support systems necessary to construct a stable habitat is difficult. The correct identification of the appropriate technologies and corresponding interfaces is an exhaustive process. Once technologies are selected secondary issues such as mechanical and electrical interfaces must be addressed. The required analytical and testing work must be approached in a piecewise fashion to achieve timely results. A repeatable process has been developed to identify and prioritize system level assessments and testing needs. This Assessment Selection Process has been defined to assess cross cutting integration issues on topics at the system or component levels. Assessments are used to identify risks, encourage future actions to mitigate risks, or spur further studies.

  19. Design studies on the engineered barrier system and on the in-situ experiments under the conditions of geological environment in Horonobe

    International Nuclear Information System (INIS)

    Kurihara, Yuji; Yui, Mikazu; Tanai, Kenji

    2004-04-01

    Following studies have been done in this papers in order to apply the technologies based on H12 report to the actual geological conditions of Horonobe underground research laboratory. 1) Reconsidering the process of repository design, the design process charts of a repository were presented. In the H12 report, the design process of the engineering barrier system was followed by the facility design process. In this paper, the both processes were placed in parallel position. 2) The relation between geological conditions and the performance of engineering barrier systems and the specifications of engineering barrier systems was arranged and the geological information needed for design of engineering barrier were selected. 3) The appropriate form of geological information as input-data for design were showed and the procedure for setting input-data was presented. 4) Based on the state of geological investigations at Horonobe, mechanical input-data were arranged for the design of the in-situ experiments on engineered barrier system at HORONOBE. 5) The stability of the hall for the in-situ experiments was studied by numerical analysis and the results indicated that there are difference in stability between the depth of 500 m and 570 m. (author)

  20. Progress in waste package and engineered barrier system performance assessment and design

    International Nuclear Information System (INIS)

    Van Luik, A.; Stahl, D.; Harrison, D.

    1993-01-01

    As part of the U.S. Department of Energy's evaluation of site suitability for a potential high-level radioactive waste repository, long-term interactions between the engineered barrier system and the site must be determined. This requires a waste-package/engineered-system design, a description of the environment around the emplacement zone, and models that simulate operative processes describing these engineered/natural systems interactions. Candidate designs are being evaluated, including a more robust, multi-barrier waste package, and a drift emplacement mode. Tools for evaluating designs, and emplacement mode are the currently available waste-package/engineered-system performance assessment codes development for the project. For assessments that support site suitability, environmental impact, or licensing decisions, more capable codes are needed. Code capability requirements are being written, and existing codes are to be evaluated against those requirements. Recommendations are being made to focus waste-packaging/engineered-system code-development

  1. Today's Yucca mountain project and a new concept of multi-barrier system

    International Nuclear Information System (INIS)

    Xu Guoqing

    2008-01-01

    This paper mainly deals with the current status of Yucca Mountain project and the progress in study on engineering barrier in Belgium and introduces the future plan for Yucca Mountain project, two reports on draft supplemental environmental impact statement, and the view of New York Sen. Hillary Clinton and Illinois Sen. Barack Obama during the 2008 president elections related to the building a nuclear waste repository in Nevada. In order to enhance the security of geological disposal of high-level radioactive waste, a new concept about multi-barrier system is given by Belgium and is concisely described here. (authors)

  2. The mechanisms of neurotoxicity and the selective vulnerability of nervous system sites.

    Science.gov (United States)

    Maurer, Laura L; Philbert, Martin A

    2015-01-01

    The spatial heterogeneity of the structure, function, and cellular composition of the nervous system confers extraordinary complexity and a multiplicity of mechanisms of chemical neurotoxicity. Because of its relatively high metabolic demands and functional dependence on postmitotic neurons, the nervous system is vulnerable to a variety of xenobiotics that affect essential homeostatic mechanisms that support function. Despite protection from the neuroglia and blood-brain barrier, the central nervous system is prone to attack from lipophilic toxicants and those that hijack endogenous transport, receptor, metabolic, and other biochemical systems. The inherent predilection of chemicals for highly conserved biochemical systems confers selective vulnerability of the nervous system to neurotoxicants. This chapter discusses selective vulnerability of the nervous system in the context of neuron-specific decrements (axonopathy, myelinopathy, disruption of neurotransmission), and the degree to which neuronal damage is facilitated or ameliorated by surrounding nonneural cells in both the central and peripheral nervous systems. © 2015 Elsevier B.V. All rights reserved.

  3. Investigation of thermal fatigue behavior of thermal barrier coating systems

    International Nuclear Information System (INIS)

    Zhu Dongming; Miller, R.A.

    1997-01-01

    In the present study, the mechanisms of fatigue crack initiation and propagation, and of coating failure under thermal loads that simulate those in diesel engines are investigated. Surface cracks initiate early and grow continuously under thermal low cycle fatigue (LCF) and high cycle fatigue (HCF) stresses. It is found that, in the absence of interfacial oxidation, the failure associated with LCF is closely related to coating sintering and creep at high temperatures. Significant LCF and HCF interactions have been observed in the thermal fatigue tests. The fatigue crack growth rate in the ceramic coating strongly depends on the characteristic HCF cycle number, N* HCF which is defined as the number of HCF cycles per LCF cycle. The crack growth rate is increased from 0.36 μm/LCF cycle for a pure LCF test to 2.8 μm/LCF cycle for a combined LCF and HCF test at N* HCF about 20 000. A surface wedging model has been proposed to account for the HCF crack growth in the coating systems. This mechanism predicts that the HCF damage effect increases with heat flux and thus with increasing surface temperature swing, thermal expansion coefficient and elastic modulus of the ceramic coating, as well as with the HCF interacting depth. Good correlation has been found between the analysis and experimental evidence. (orig.)

  4. PILOT-SCALE EVALUATION OF ENGINEERED BARRIER SYSTEMS FOR THE YUCCA MOUNTAIN PROJECT

    International Nuclear Information System (INIS)

    Webb, S.W.; George, J.T.; Finley, R.E.

    2001-01-01

    This paper describes two quarter-scale experiments (1.4 m diameter) and associated numerical analyses on granular backfill engineered barrier systems in support of the Yucca Mountain Project for the potential repository. The two configurations include a sloped capillary barrier and a plain backfill. The tests involve application of dyed water as a constant line infiltration source along the top of the test set-up, monitoring water movement through the test, and measuring water exiting the experiments. A complete water balance estimate is made for each test, and observed water movement is compared with (1) detailed numerical analyses conducted using the TOUGH2 code for unsaturated flow in porous media and (2) posttest observations. The results of the testing and analyses show that for the injection rates and configuration applied, the capillary barrier design diverts a significant amount of all injected water and the TOUGH2 pretest predictions show qualitative and quantitative agreement with the experimental data

  5. Influences of engineered barrier systems on low-level radioactive waste disposal

    Energy Technology Data Exchange (ETDEWEB)

    Buckley, L. P.

    1987-09-15

    There are major differences between the current practices of shallow land burial and alternative concepts for the disposal of low-level radioactive wastes. Additional protection provided with engineered barrier systems can overcome major concerns the public has with shallow land burial: subsidence; percolating ground waters; radionuclide migration; and the vulnerability of shallow trenches to intrusion. The presence of a variety of engineered barriers to restrict water movement, retain radionuclides and to prevent plant animal or human intrusion leads to significant changes to input data for performance assessment models. Several programs which are underway to more accurately predict the long-term performance of engineered barriers for low-level waste will be described.

  6. Barriers to Participation in Learning Management Systems in Saudi Arabian Universities

    Directory of Open Access Journals (Sweden)

    Abdullah Alenezi

    2018-01-01

    Full Text Available This study was designed to identify various barriers that have hindered the adoption of LMSs in Saudi Arabian universities. Learning management systems (LMSs have been adopted in many learning institutions because of their functionalities and applications to improve pedagogy. Universities have been encouraged to use LMSs to enhance the collaborative working environment among students and between the students and their instructors. This study was done by administering 150 questionnaires to students in three universities in Saudi Arabia. Findings from the study revealed that the main barriers to the use of LMSs were inadequate technical support by the universities, negative attitude toward technology, and inadequate training on the LMS platforms. Minor barriers identified include poor Internet access and networking, limited infrastructure to support the LMS, lack of hardware and software to run the LMS, and challenges in English language proficiency.

  7. Influences of engineered barrier systems on low-level radioactive waste disposal

    International Nuclear Information System (INIS)

    Buckley, L.P.

    1987-09-01

    There are major differences between the current practices of shallow land burial and alternative concepts for the disposal of low-level radioactive wastes. Additional protection provided with engineered barrier systems can overcome major concerns the public has with shallow land burial: subsidence; percolating ground waters; radionuclide migration; and the vulnerability of shallow trenches to intrusion. The presence of a variety of engineered barriers to restrict water movement, retain radionuclides and to prevent plant animal or human intrusion leads to significant changes to input data for performance assessment models. Several programs which are underway to more accurately predict the long-term performance of engineered barriers for low-level waste will be described

  8. Barriers And Motivators for Smoking Cessation in Patients With Systemic Lupus Erythematosus (SLE).

    Science.gov (United States)

    Terrell, Deirdra R; Stewart, Lauren M; Tolma, Eleni L; McClain, Rebekah; Vesely, Sara K; James, Judith A

    2015-11-01

    Although studies have shown that smoking is detrimental to the health of patients with systemic lupus erythematosus (SLE), studies regarding barriers and motivators for smoking cessation are lacking. The purpose of this study was to generate hypotheses regarding the barriers and motivators for smoking cessation in SLE patients. This study was based on the theoretical framework of the stages of change model. All participants met SLE classification criteria. Interviews were conducted with 16 current and 10 former smokers. Motivators included: medical reasons, readiness, and concern for others. Barriers included: enjoyment, coping mechanism, and an emotional connection. Participants were unsure of the impact of smoking on their medication and disease, and had mixed feelings regarding the impact on pain. The main motivator for cessation in this population was concern for one's health. Rheumatologists need to include disease specific harms and assess pain management strategies as part of cessation counseling.

  9. Application of CFRP with High Hydrogen Gas Barrier Characteristics to Fuel Tanks of Space Transportation System

    Science.gov (United States)

    Yonemoto, Koichi; Yamamoto, Yuta; Okuyama, Keiichi; Ebina, Takeo

    In the future, carbon fiber reinforced plastics (CFRPs) with high hydrogen gas barrier performance will find wide applications in all industrial hydrogen tanks that aim at weight reduction; the use of such materials will be preferred to the use of conventional metallic materials such as stainless steel or aluminum. The hydrogen gas barrier performance of CFRP will become an important issue with the introduction of hydrogen-fuel aircraft. It will also play an important role in realizing fully reusable space transportation system that will have high specific tensile CFRP structures. Such materials are also required for the manufacture of high-pressure hydrogen gas vessels for use in the fuel cell systems of automobiles. This paper introduces a new composite concept that can be used to realize CFRPs with high hydrogen gas barrier performance for applications in the cryogenic tanks of fully reusable space transportation system by the incorporation of a nonmetallic crystal layer, which is actually a dense and highly oriented clay crystal laminate. The preliminary test results show that the hydrogen gas barrier characteristics of this material after cryogenic heat shocks and cyclic loads are still better than those of other polymer materials by approximately two orders of magnitude.

  10. Selective conversion of methane to synthetic fuels using dielectric barrier discharge contacting liquid film

    Energy Technology Data Exchange (ETDEWEB)

    Nozaki, Tomohiro; Goujard, Valentin; Yuzawa, Shuhei; Moriyama, Shota; Okazaki, Ken [Department of Mechanical and Control Engineering, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro, Tokyo 1528552 (Japan); Agiral, Anil, E-mail: tnozaki@mech.titech.ac.jp [Mesoscale Chemical Systems, MESA Institute for Nanotechnology, Faculty of Science and Technology, University of Twente, PO Box 217, 7500 AE, Enschede (Netherlands)

    2011-07-13

    This paper presents the reaction mechanism of single-step methane partial oxidation to methanol at room temperature using non-thermal plasma microreactor. Macroscopic quantities of hydrogen peroxide (H{sub 2}O{sub 2}) and methyl hydroperoxide (CH{sub 3}OOH) are produced when methane is partially oxidized at room temperature (about 5 {sup 0}C). CH{sub 3}OOH is known to be the principle intermediate of incomplete methane oxidation product such as CH{sub 3}OH and HCHO, but has not been demonstrated experimentally so far. H{sub 2}O{sub 2} promotes post-plasma oxidation of oxygenates in the condensed plasma-synthesized liquid. At an early stage of in-liquid oxidation, H{sub 2}O{sub 2} oxidizes HCHO into HCOOH preferentially; subsequently, HCOOH is fully oxidized to CO{sub 2} and H{sub 2}O. Depending upon the concentration of oxygenates and H{sub 2}O{sub 2}, electrical conductivity of the plasma solution dramatically increased, which detrimentally influences plasma properties. Methane partial oxidation with air was also investigated from a practical viewpoint. Generation of active nitrogen species (ANS) is the key to promoting overall methane conversion in the presence of oxygen; however, fragile oxygenates were also decomposed by ANS, thus selectivity for useful oxygenates was degraded in the presence of nitrogen. When oxygen is fully consumed, CH{sub 4} conversion is also terminated and water gas shift reaction (CO + H{sub 2}O = CO{sub 2} + H{sub 2}) becomes predominant.

  11. Motivators, Barriers and Concerns in Adoption of Electronic Filing System: Survey Evidence from Malaysian Professional Accountants

    OpenAIRE

    Ming-Ling Lai; Kwai-Fatt Choong

    2010-01-01

    Problem statement: Worldwide, electronic filing (e-filing) system and its' adoption has attracted much attention, however, scholarly study on accounting professionals' acceptance of e-filing system is scant. Approach: This study aimed (i) to examine factors that motivated professional accountants to use e-filing (ii) to solicit their usage experience and (iii) to assess the barriers to adoption and other compliance considerations. The questionnaire survey was administered on 700 professionals...

  12. Astrocytic TYMP and VEGFA drive blood-brain barrier opening in inflammatory central nervous system lesions.

    Science.gov (United States)

    Chapouly, Candice; Tadesse Argaw, Azeb; Horng, Sam; Castro, Kamilah; Zhang, Jingya; Asp, Linnea; Loo, Hannah; Laitman, Benjamin M; Mariani, John N; Straus Farber, Rebecca; Zaslavsky, Elena; Nudelman, German; Raine, Cedric S; John, Gareth R

    2015-06-01

    In inflammatory central nervous system conditions such as multiple sclerosis, breakdown of the blood-brain barrier is a key event in lesion pathogenesis, predisposing to oedema, excitotoxicity, and ingress of plasma proteins and inflammatory cells. Recently, we showed that reactive astrocytes drive blood-brain barrier opening, via production of vascular endothelial growth factor A (VEGFA). Here, we now identify thymidine phosphorylase (TYMP; previously known as endothelial cell growth factor 1, ECGF1) as a second key astrocyte-derived permeability factor, which interacts with VEGFA to induce blood-brain barrier disruption. The two are co-induced NFκB1-dependently in human astrocytes by the cytokine interleukin 1 beta (IL1B), and inactivation of Vegfa in vivo potentiates TYMP induction. In human central nervous system microvascular endothelial cells, VEGFA and the TYMP product 2-deoxy-d-ribose cooperatively repress tight junction proteins, driving permeability. Notably, this response represents part of a wider pattern of endothelial plasticity: 2-deoxy-d-ribose and VEGFA produce transcriptional programs encompassing angiogenic and permeability genes, and together regulate a third unique cohort. Functionally, each promotes proliferation and viability, and they cooperatively drive motility and angiogenesis. Importantly, introduction of either into mouse cortex promotes blood-brain barrier breakdown, and together they induce severe barrier disruption. In the multiple sclerosis model experimental autoimmune encephalitis, TYMP and VEGFA co-localize to reactive astrocytes, and correlate with blood-brain barrier permeability. Critically, blockade of either reduces neurologic deficit, blood-brain barrier disruption and pathology, and inhibiting both in combination enhances tissue preservation. Suggesting importance in human disease, TYMP and VEGFA both localize to reactive astrocytes in multiple sclerosis lesion samples. Collectively, these data identify TYMP as an

  13. Internal resistor of multi-functional tunnel barrier for selectivity and switching uniformity in resistive random access memory.

    Science.gov (United States)

    Lee, Sangheon; Woo, Jiyong; Lee, Daeseok; Cha, Euijun; Hwang, Hyunsang

    2014-01-01

    In this research, we analyzed the multi-functional role of a tunnel barrier that can be integrated in devices. This tunnel barrier, acting as an internal resistor, changes its resistance with applied bias. Therefore, the current flow in the devices can be controlled by a tunneling mechanism that modifies the tunnel barrier thickness for non-linearity and switching uniformity of devices. When a device is in a low-resistance state, the tunnel barrier controls the current behavior of the device because most of the bias is applied to the tunnel barrier owing to its higher resistance. Furthermore, the tunnel barrier induces uniform filament formation during set operation with the tunnel barrier controlling the current flow.

  14. A Study of the Bolt Connection System for a Concrete Barrier of a Modular Bridge

    Directory of Open Access Journals (Sweden)

    Doo-Yong Cho

    2018-04-01

    Full Text Available Modular technology has been recently studied to reduce the construction periods in the field of bridge construction. However, this method is restricted to the pier, girder, and deck, which are the main members of a bridge, and incidental facilities such as concrete barriers have been rarely studied. Thus, in this study, the connection system of a concrete barrier for modular bridges was developed, and a static loading experiment was performed to verify the structural capacity of the proposed system. The variables of the experiment were the vertical and horizontal bolt connections and the construction method. The barrier and plate were fabricated using match casting methods in which nuts were first inserted into the plates rather than anchor bolts using the conservative method. Moreover, a comparison with the conventional in situ barrier was also performed. The experiments were conducted according to the AASHTO LRFD standard. Consequently, the specimen using the vertical bolt connection had a structural capacity that was equal to 85% of that of the conventional specimen and exhibited similar crack patterns compared with the conventional specimen. In the case of the horizontal bolt connection, the separation in the connection area occurred with the application of the initial load and this specimen exhibited a poor performance because of the increase in the separation distance with the application of the maximum load.

  15. Selective Toll-Like Receptor 4 Antagonists Prevent Acute Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in Mice.

    Science.gov (United States)

    Okada, Takeshi; Kawakita, Fumihiro; Nishikawa, Hirofumi; Nakano, Fumi; Liu, Lei; Suzuki, Hidenori

    2018-05-31

    There are no direct evidences showing the linkage between Toll-like receptor 4 (TLR4) and blood-brain barrier (BBB) disruption after subarachnoid hemorrhage (SAH). The purpose of this study was to examine if selective blockage of TLR4 prevents BBB disruption after SAH in mice and if the TLR4 signaling involves mitogen-activated protein kinases (MAPKs). One hundred and fifty-one C57BL/6 male mice underwent sham or endovascular perforation SAH operation, randomly followed by an intracerebroventricular infusion of vehicle or two dosages (117 or 585 ng) of a selective TLR4 antagonist IAXO-102 at 30 min post-operation. The effects were evaluated by survival rates, neurological scores, and brain water content at 24-72 h and immunoglobulin G immunostaining and Western blotting at 24 h post-SAH. IAXO-102 significantly prevented post-SAH neurological impairments, brain edema, and BBB disruption, resulting in improved survival rates. IAXO-102 also significantly suppressed post-SAH activation of a major isoform of MAPK p46 c-Jun N-terminal kinase (JNK) and matrix metalloproteinase-9 as well as periostin induction and preserved tight junction protein zona occludens-1. Another selective TLR4 antagonist TAK-242, which has a different binding site from IAXO-102, also showed similar effects to IAXO-102. This study first provided the evidence that TLR4 signaling is involved in post-SAH acute BBB disruption and that the signaling is mediated at least partly by JNK activation. TLR4-targeted therapy may be promising to reduce post-SAH morbidities and mortalities.

  16. An evaluation of the fire barrier system thermo-lag 330-1

    International Nuclear Information System (INIS)

    Nowlen, S.P.

    1994-09-01

    This report presents the results of three fire endurance tests and one ampacity derating test set of the fire barrier system Thermo-Lag 330-1 Subliming Coating. Each test was performed using cable tray specimens protected by a nominal three-hour fire barrier envelope comprised of two layers of nominal 1/2 inch thick material. The fire barrier systems for two of the three fire endurance test articles and for the ampacity derating test article were installed in accordance with the manufacturer's installations procedures. The barrier system for the third fire endurance test article was a full reproduction of one of the original manufacturer's qualification test articles. This final test article included certain installation enhancements not considered typical of current nuclear power plant installations. The primary criteria for fire endurance performance evaluation was based on cable circuit integrity testing. Secondary consideration was also given to the temperature rise limits set forth in the ASTM E119 standard fire barrier test procedure. All three of the fire endurance specimens failed prematurely. Circuit integrity failures for the two fire endurance test articles with procedures-based installations were recorded at approximately 76 and 59 minutes into the exposures for a 6 inch wide and 12 inch wide cable tray respectively. Temperature excursion failures (single point) for these two test articles were noted at approximately 65 and 56 minutes respectively. The first circuit integrity failure for the full reproduction test article was recorded approximately 119 minutes into the exposure, and the first temperature excursion failure for this test article was recorded approximately 110 minutes into the exposure

  17. Development of a Mechanical Analysis System Considering Chemical Transitions of Barrier Materials

    International Nuclear Information System (INIS)

    Sahara, F.; Murakami, T.; Ito, H.; Kobayashi, I.; Yokozeki, K.

    2006-01-01

    An analysis system for the long-term mechanical behavior of barrier materials (MACBECE: Mechanical Analysis system considering Chemical transitions of Bentonite-based and Cement-based materials) was developed in order to improve the reliability of the evaluation of the hydraulic field that is one of the important environmental conditions in the safety assessment of the TRU waste disposal in Japan. The MACBECE is a system that calculates the deformation of barrier materials using their chemical property changes as inputs, and subsequently their hydraulic conductivity taking both their chemical property changes and deformation into consideration. This paper provides a general description of MACBECE and the results of experimental analysis carried out using MACBECE. (authors)

  18. Investigation on the Interface Characteristics of the Thermal Barrier Coating System through Flat Cylindrical Indenters

    Directory of Open Access Journals (Sweden)

    Shifeng Wen

    2014-01-01

    Full Text Available Thermal barrier coating (TBC systems are highly advanced material systems and usually applied to insulate components from large and prolonged heat loads by utilizing thermally insulating materials. In this study, the characteristics of the interface of thermal barrier coating systems have been simulated by the finite-element method (FEM. The emphasis was put on the stress distribution at the interface which is beneath the indenter. The effect of the interface roughness, the thermally grown oxide (TGO layer's thickness, and the modulus ratio (η of the thin film with the substrate has been considered. Finite-element results showed that the influences of the interface roughness and the TGO layer's thickness on stress distribution were important. At the same time, the residual stress distribution has been investigated in detail.

  19. ERP systems selection in multinational enterprises: a practical guide

    OpenAIRE

    Moutaz Haddara

    2018-01-01

    The Enterprise Resource Planning (ERP) system selection is an early phase in the ERP adoption process. When organizations evaluate an ERP, they commonly develop their own selection criteria that usually involve various system and vendor related factors. While the selection process is critical, however, there is an apparent research gap in literature. The ERP selection effort also focuses on the system’s fit with the organizational requirements and needs. Thus, the selection phase is critical,...

  20. System driven technology selection for future European launch systems

    Science.gov (United States)

    Baiocco, P.; Ramusat, G.; Sirbi, A.; Bouilly, Th.; Lavelle, F.; Cardone, T.; Fischer, H.; Appel, S.

    2015-02-01

    In the framework of the next generation launcher activity at ESA, a top-down approach and a bottom-up approach have been performed for the identification of promising technologies and alternative conception of future European launch vehicles. The top-down approach consists in looking for system-driven design solutions and the bottom-up approach features design solutions leading to substantial advantages for the system. The main investigations have been focused on the future launch vehicle technologies. Preliminary specifications have been used in order to permit sub-system design to find the major benefit for the overall launch system. The development cost, non-recurring and recurring cost, industrialization and operational aspects have been considered as competitiveness factors for the identification and down-selection of the most interesting technologies. The recurring cost per unit payload mass has been evaluated. The TRL/IRL has been assessed and a preliminary development plan has been traced for the most promising technologies. The potentially applicable launch systems are Ariane and VEGA evolution. The main FLPP technologies aim at reducing overall structural mass, increasing structural margins for robustness, metallic and composite containment of cryogenic hydrogen and oxygen propellants, propellant management subsystems, elements significantly reducing fabrication and operational costs, avionics, pyrotechnics, etc. to derive performing upper and booster stages. Application of the system driven approach allows creating performing technology demonstrators in terms of need, demonstration objective, size and cost. This paper outlines the process of technology down selection using a system driven approach, the accomplishments already achieved in the various technology fields up to now, as well as the potential associated benefit in terms of competitiveness factors.

  1. Rehabilitation of a house with high radon level, using a ground ventilation system with double barrier

    International Nuclear Information System (INIS)

    Bonnefous, Y.C.; Richon, P.; Arnautou, J.C.; Sabroux, J.C.

    1995-01-01

    A ground ventilation system has been designed and implemented in a town hall in Brittany. Radon concentration in the heating unit room of this building has been reduced from 10000 Bq/m 3 to less than 200 Bq/m 3 by the means of a depressurization system using a 32 W fan, which blows air into a permeable gravel layer intercalated between two radon barrier mylar films. Results show that passive systems should be applicable; for new buildings, very low energy consumption systems with 10 W fans, are easily implemented if designed before construction

  2. ARTIFICIAL NEURAL NETWORKS BASED GEARS MATERIAL SELECTION HYBRID INTELLIGENT SYSTEM

    Institute of Scientific and Technical Information of China (English)

    X.C. Li; W.X. Zhu; G. Chen; D.S. Mei; J. Zhang; K.M. Chen

    2003-01-01

    An artificial neural networks(ANNs) based gear material selection hybrid intelligent system is established by analyzing the individual advantages and weakness of expert system (ES) and ANNs and the applications in material select of them. The system mainly consists of tow parts: ES and ANNs. By being trained with much data samples,the back propagation (BP) ANN gets the knowledge of gear materials selection, and is able to inference according to user input. The system realizes the complementing of ANNs and ES. Using this system, engineers without materials selection experience can conveniently deal with gear materials selection.

  3. Next generation of non-mammalian blood-brain barrier models to study parasitic infections of the central nervous system

    OpenAIRE

    Siddiqui, Ruqaiyyah; Edwards-Smallbone, James; Flynn, Robin; Khan, Naveed Ahmed

    2012-01-01

    Transmigration of neuropathogens across the blood-brain barrier is a key step in the development of central nervous system infections, making it a prime target for drug development. The ability of neuropathogens to traverse the blood-brain barrier continues to inspire researchers to understand the specific strategies and molecular mechanisms that allow them to enter the brain. The availability of models of the blood-brain barrier that closely mimic the situation in vivo offers unprecedented o...

  4. Reducing Barriers To The Use of High-Efficiency Lighting Systems

    Energy Technology Data Exchange (ETDEWEB)

    Peter Morante

    2005-12-31

    With funding from the U.S. Department of Energy (DOE), the Lighting Research Center (LRC) at Rensselaer Polytechnic Institute completed the four-year research project, Reducing Barriers to the Use of High-Efficiency Lighting Systems. The initial objectives were: (1) identifying barriers to widespread penetration of lighting controls in commercial/industrial (C/I) applications that employ fluorescent lamp technologies, and (2) making recommendations to overcome these barriers. The addition of a fourth year expanded the original project objectives to include an examination of the impact on fluorescent lamps from dimming utilizing different lamp electrode heating and dimming ratios. The scope of the project was narrowed to identify barriers to the penetration of lighting controls into commercial-industrial (C/I) applications that employ fluorescent lamp technologies, and to recommend means for overcoming these barriers. Working with lighting manufacturers, specifiers, and installers, the project identified technological and marketing barriers to the widespread use of lighting controls, specifically automatic-off controls, occupancy sensors, photosensors, dimming systems, communication protocols and load-shedding ballasts. The primary barriers identified include cost effectiveness of lighting controls to the building owner, lack of standard communication protocols to allow different part of the control system to communicate effectively, and installation and commissioning issues. Overcoming the identified barriers requires lighting control products on the market to achieve three main goals: (1) Achieve sufficient functionality to meet the key requirements of their main market. (2) Allow significant cost reduction compared to current market standard systems. Cost should consider: hardware capital cost including wiring, design time required by the specifier and the control system manufacturer, installation time required by the electrician, and commissioning time and

  5. Barriers in the Implementation of Health Information Systems: A Scoping Review

    Directory of Open Access Journals (Sweden)

    Florin STAMATIAN

    2013-12-01

    Full Text Available Context. A well-developed health information system which is implemented according to present standards allows a healthcare quality increase. Our study aims at providing an overview of the barriers which were encountered in the process of implementing the health information systems by reviewing the literature connected to Europe and the United States of America. Methodology. We searched within five databases (Cochrane Library, Google Scholar, PubMed, ScienceDirect and Scopus for the exact phrase ‘implementation health information system’ along with the name of each European country/USA state. Relevance was then tested by scanning titles and abstracts. The third and final step involved assessing all the articles in order to set their relevance and a data extraction tool was created, containing the name of the state/country that the article reports data on, the article citation and the challenges identified. Results. The barriers identified were classified in four major categories: technical, organizational, behavioral/human and financial. Seemingly, Europe (41 articles and USA (20 articles are facing the same issues in the implementation of a health information system. No major difference between EU and non-EU countries was found after our analysis with regards to the identified barriers. Discussion. Even if recommendations and solutions are continuously being developed in order to solve these barriers, the implementation of a new health information system must be very detailed in order to face all these problems. Additionally, further research is required in order to evaluate their impact on the successful implementation of a health information system.

  6. A method of providing a barrier in a fracture-containing system

    DEFF Research Database (Denmark)

    2014-01-01

    The present invention relates to a method of providing a barrier in a fracture-containing system, comprising: i) Providing a treatment fluid comprising: a) a base fluid; b) an elastomeric material, wherein said elastomeric material comprises at least one polymer capable of crosslinking into an el......The present invention relates to a method of providing a barrier in a fracture-containing system, comprising: i) Providing a treatment fluid comprising: a) a base fluid; b) an elastomeric material, wherein said elastomeric material comprises at least one polymer capable of crosslinking...... into an elastomer, and c) at least one crosslinking agent; ii) Placing the treatment fluid in a fracture-containing system; iii) Allowing the elastomeric material to crosslink with itself to form a barrier in said fracture-containing system; wherein the elastomeric material and/or the crosslinking agent...... are of neutral buoyancy with regard to the base fluid. The invention is contemplated to having utility not only in the oil-drilling industry but also in the plugging of fractures in sewer drains, pipelines etc....

  7. Assessment on mechanical effect of engineering barrier system to fault movement. Research document

    International Nuclear Information System (INIS)

    Hirai, Takashi; Tanai, Kenji; Takaji, Kazuhiko; Ohnuma, Satoshi

    2003-03-01

    The objective of this report is to clarify mechanical effect of engineering barrier system to the unavoidable fault movement. From the basic policy of the second progress report by JNC, natural phenomenon which affect strongly to the geological disposal system should be avoided. However, small faults as sliprate ''C'' far from principal fault zone, are difficult to be found out completely. Therefore, it is important to evaluate the influence of these fault movements and to clarify stability and safety of the engineered barrier system. Accordingly, the effect of a rock displacement across a deposition holl was considered and the midium scale test was carried out. Then midium scale test was simulated by Finit Element Method in which the constitutive model of Tresca was adopted to analyze elastoplastic behavior of buffer material. From the result of the midium scale test and the analysis, it was realized that the buffer material diminish shear stress acting on the overpack. Further analytical study was conducted to evaluate the real scale engineered barrier system designed in the second progress report by JNC. From the study, it was appeared that stress in buffer corresponded to the stress calculated for the midium scale test model. Consequently, it was obvious that rock displacement, 80% of buffer didn't affect overpack if velocity of fault movement was under 10 cm/sec. (author)

  8. Measurements of barrier distributions for the system {sup 8}Li+{sup 120}Sn

    Energy Technology Data Exchange (ETDEWEB)

    Rossi Junior, E.S. [Centro Universitario FIEO (UNIFIEO), Osasco, SP (Brazil); Guimaraes, V.; Barioni, A.; Morais, M.C.; Faria, P.N. de; Lepine-Szily, A.; Lichtenthaeler Filho, R.; Crema, E.; Cardona, J.C.A. [Universidade de Sao Paulo (IF/USP), SP (Brazil). Inst. de Fisica; Monteiro, D.S. [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil). Inst. de Fisica; Huiza, J.F.P. [Universidade Estadual do Sudoeste da Bahia (UESB), Jequie, BA (Brazil); Shorto, J.M.B. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-07-01

    Full text: The investigation of exotic nuclei, where the appearance of various effects and phenomena such as halo effect, skin of nucleons, new forms of decay, different spacing between the levels and new magic numbers in the shell model, has attracted a great motivation to investigate and study these nuclei in detail. Thus, important effects such as competition and interference between the reaction mechanisms, coupling between channels, can be investigated and analyzed in detail. The results of precise measurements of quasi-elastic barrier distributions can be used to develop and verify the validity of new models of reactions and new analytical techniques, making use of polarization potentials and calculations of CDCC (Continuum Discretized Coupled Channels). These measurements at energies near the Coulomb barrier can provide also information about the nuclear structure and reaction mechanisms. Recently, measurements of quasi-elastic barrier distributions for the system {sup 8}Li + {sup 120}Sn were carried out at energies around the Coulomb barrier (19.0, 20.4, 21.4 and 23.5 MeV) at the Pelletron laboratory. In this work, we will present the preliminary results of those measurements. (author)

  9. 46 CFR 108.404 - Selection of fire detection system.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Selection of fire detection system. 108.404 Section 108... DESIGN AND EQUIPMENT Fire Extinguishing Systems § 108.404 Selection of fire detection system. (a) If a... space. (b) The fire detection system must be designed to minimize false alarms. ...

  10. Fusion of light ion systems at energies near and below the Coulomb barrier

    International Nuclear Information System (INIS)

    Arnould, M.; Howard, W.M.; Cusson, R.Y.

    1978-01-01

    Experimental fusion cross sections for light ion systems at energies below the Coulomb barrier become available in greater and greater number, and provide a stringent test of the macroscopic and microscopic physics involved in models of heavy-ion reactions. Measurements and predictions of the fusion cross sections for 12 C + 12 C, 12 C + 16 O and 16 O + 16 O are also of major importance in astrophysics. (orig.) [de

  11. CONDITIONS FOR OVERCOMING COMMUNICATION-LANGUAGE BARRIERS IN THE SYSTEM OF NON-LINGUISTIC HIGHER EDUCATION

    Directory of Open Access Journals (Sweden)

    Lidiya Olegovna Polyakova

    2016-01-01

    Results. Results of our scientific work are such conditions should be implemented based on the principle of «vertical integration», covering the social levels of the customer of higher education (economic sector, national systems of higher education, the University, the faculty, the chair. Practical implications. Presents a set of tools that is effective in solving problems of communication-language barriers of future specialists of non-linguistic profile.

  12. Stationary responses of a Rayleigh viscoelastic system with zero barrier impacts under external random excitation.

    Science.gov (United States)

    Wang, Deli; Xu, Wei; Zhao, Xiangrong

    2016-03-01

    This paper aims to deal with the stationary responses of a Rayleigh viscoelastic system with zero barrier impacts under external random excitation. First, the original stochastic viscoelastic system is converted to an equivalent stochastic system without viscoelastic terms by approximately adding the equivalent stiffness and damping. Relying on the means of non-smooth transformation of state variables, the above system is replaced by a new system without an impact term. Then, the stationary probability density functions of the system are observed analytically through stochastic averaging method. By considering the effects of the biquadratic nonlinear damping coefficient and the noise intensity on the system responses, the effectiveness of the theoretical method is tested by comparing the analytical results with those generated from Monte Carlo simulations. Additionally, it does deserve attention that some system parameters can induce the occurrence of stochastic P-bifurcation.

  13. Altered Blood-Brain Barrier Permeability in Patients With Systemic Lupus Erythematosus: A Novel Imaging Approach.

    Science.gov (United States)

    Gulati, Gaurav; Jones, Jordan T; Lee, Gregory; Altaye, Mekibib; Beebe, Dean W; Meyers-Eaton, Jamie; Wiley, Kasha; Brunner, Hermine I; DiFrancesco, Mark W

    2017-02-01

    To evaluate a safe, noninvasive magnetic resonance imaging (MRI) method to measure regional blood-brain barrier integrity and investigate its relationship with neurocognitive function and regional gray matter volume in juvenile-onset systemic lupus erythematosus (SLE). In this cross-sectional, case-control study, capillary permeability was measured as a marker of blood-brain barrier integrity in juvenile SLE patients and matched healthy controls, using a combination of arterial spin labeling and diffusion-weighted brain MRI. Regional gray matter volume was measured by voxel-based morphometry. Correlation analysis was done to investigate the relationship between regional capillary permeability and regional gray matter volume. Formal neurocognitive testing was completed (measuring attention, visuoconstructional ability, working memory, and psychomotor speed), and scores were regressed against regional blood-brain barrier integrity among juvenile SLE patients. Formal cognitive testing confirmed normal cognitive ability in all juvenile SLE subjects (n = 11) included in the analysis. Regional capillary permeability was negatively associated (P = 0.026) with neurocognitive performance concerning psychomotor speed in the juvenile SLE cohort. Compared with controls (n = 11), juvenile SLE patients had significantly greater capillary permeability involving Brodmann's areas 19, 28, 36, and 37 and caudate structures (P < 0.05 for all). There is imaging evidence of increased regional capillary permeability in juvenile SLE patients with normal cognitive performance using a novel noninvasive MRI technique. These blood-brain barrier outcomes appear consistent with functional neuronal network alterations and gray matter volume loss previously observed in juvenile SLE patients with overt neurocognitive deficits, supporting the notion that blood-brain barrier integrity loss precedes the loss of cognitive ability in juvenile SLE. Longitudinal studies are needed to

  14. Vegetation barrier and tillage effects on runoff and sediment in an alley crop system on a Luvisol in Burkina Faso

    NARCIS (Netherlands)

    Spaan, W.P.; Sikking, A.F.S.; Hoogmoed, W.B.

    2005-01-01

    The effects of vegetation barriers and tillage on runoff and soil loss were evaluated in an alley crop system at a research station in central Burkina Faso. On a 2% slope of a sandy loam various local species (grasses, woody species and a succulent) were planted as conservation barriers in order to

  15. SADA: Ecological Risk Based Decision Support System for Selective Remediation

    Science.gov (United States)

    Spatial Analysis and Decision Assistance (SADA) is freeware that implements terrestrial ecological risk assessment and yields a selective remediation design using its integral geographical information system, based on ecological and risk assessment inputs. Selective remediation ...

  16. The intestinal barrier in irritable bowel syndrome: subtype-specific effects of the systemic compartment in an in vitro model.

    Directory of Open Access Journals (Sweden)

    Samefko Ludidi

    Full Text Available Irritable bowel syndrome (IBS is a disorder with multifactorial pathophysiology. Intestinal barrier may be altered, especially in diarrhea-predominant IBS (IBS-D. Several mediators may contribute to increased intestinal permeability in IBS.We aimed to assess effects of tryptase and LPS on in vitro permeability using a 3-dimensional cell model after basolateral cell exposure. Furthermore, we assessed the extent to which these mediators in IBS plasma play a role in intestinal barrier function.Caco-2 cells were grown in extracellular matrix to develop into polarized spheroids and were exposed to tryptase (10 - 50 mU, LPS (1 - 50 ng/mL and two-fold diluted plasma samples of 7 patients with IBS-D, 7 with constipation-predominant IBS (IBS-C and 7 healthy controls (HC. Barrier function was assessed by the flux of FITC-dextran (FD4 using live cell imaging. Furthermore, plasma tryptase and LPS were determined.Tryptase (20 and 50 mU and LPS (6.25 - 50 ng/mL significantly increased Caco-2 permeability versus control (all P< 0.05. Plasma of IBS-D only showed significantly elevated median tryptase concentrations (7.1 [3.9 - 11.0] vs. 4.2 [2.2 - 7.0] vs. 4.2 [2.5 - 5.9] μg/mL; P<0.05 and LPS concentrations (3.65 [3.00 - 6.10] vs. 3.10 [2.60-3.80] vs. 2.65 [2.40 - 3.40] EU/ml; P< 0.05 vs. IBS-C and HC. Also, plasma of IBS-D increased Caco-2 permeability versus HC (0.14450 ± 0.00472 vs. 0.00021 ± 0.00003; P < 0.001, which was attenuated by selective inhibition of tryptase and LPS (P< 0.05.Basolateral exposure of spheroids to plasma of IBS-D patients resulted in a significantly increased FD4 permeation, which was partially abolished by selective inhibition of tryptase and LPS. These findings point to a role of systemic tryptase and LPS in the epithelial barrier alterations observed in patients with IBS-D.

  17. Nagra technical report 14-03, characteristic dosage intervals and documentation for the assessment of barrier systems

    International Nuclear Information System (INIS)

    2014-12-01

    This comprehensive technical report published by the Swiss National Cooperative for the Disposal of Radioactive Wastes Nagra discusses the procedure for selecting sites for deep geological repositories for all categories of radioactive waste produced in Switzerland, as defined in the conceptual part of the Sectoral Plan for Deep Geological Repositories (BFE 2008). Analyses are presented and discussed that determine the priority host rocks for the disposal of low, intermediate and high level radioactive wastes. The evaluation of the effectiveness of the barrier systems is discussed. Also, analyses are presented and discussed in connection with the regions where sites for the repositories may be located. Important site-specific geological information is examined which is to be used in the assessment of possible repository sites from the safety analysis point of view

  18. Organizational human factors as barriers to energy efficiency in electrical motors systems in industry

    International Nuclear Information System (INIS)

    Sola, Antonio Vanderley Herrero; Augusto de Paula, Xavier Antonio

    2007-01-01

    This paper presents a study accomplished in the State of Parana in Southern Brazil, aiming at verifying the correlation between organizational human factors (OHF) and the level of energy losses in organizations. The purpose is to subsidize the formularization of institutional policies in organizations to improve the energy efficiency in the productive sector. The research was carried out in ten industries of the following sectors: pulp and paper; food; wood and chemical products. The losses of electric energy were determined in motor systems with the aid of a mathematical model and the evaluation of 27 OHF identified in the literature review was made with the supervisors in the industries by means of a structurized questionnaire. Seven OHF had presented significant correlation with energy losses and six of them are inversely proportional to the losses, in accordance with linear regression analysis. The inversely proportional factors to the losses also with significant correlation are considered determinative OHF and constitute barriers for energy efficiency in organizations. These barriers are linked with the following organizational areas: management system; education of employees; strategical vision. The study recommends the implementation of the determinative OHF in organizations as a way to transpose the human barriers for energy efficiency

  19. A Fast Adaptive Receive Antenna Selection Method in MIMO System

    Directory of Open Access Journals (Sweden)

    Chaowei Wang

    2013-01-01

    Full Text Available Antenna selection has been regarded as an effective method to acquire the diversity benefits of multiple antennas while potentially reduce hardware costs. This paper focuses on receive antenna selection. According to the proportion between the numbers of total receive antennas and selected antennas and the influence of each antenna on system capacity, we propose a fast adaptive antenna selection algorithm for wireless multiple-input multiple-output (MIMO systems. Mathematical analysis and numerical results show that our algorithm significantly reduces the computational complexity and memory requirement and achieves considerable system capacity gain compared with the optimal selection technique in the same time.

  20. Project Guarantee 1985. Final repository for low- and intermediate-level radioactive wastes: The system of safety barriers

    International Nuclear Information System (INIS)

    Anon.

    1985-01-01

    The safety barrier system for the type B repository for low- and intermediate-level waste is described. The barrier parameters which are relevant for safety analysis are quantified and associated error limits and data scatter are given. The aim of the report is to give a summary documentation of the safety analysis input data and their scientific background. For secure containment of radioactive waste safety barriers are used which effectively limit the release of radioactive material from the repository (release barriers) and effectively retard the entry of the original radioactive material into the biosphere (time barriers). In the case of low- and intermediate-level waste the technical safety barrier system comprises: waste solidification matrix (cement, bitumen and resin), immobilisation of the waste packages in containers using liquid cement, concrete repository containers, backfilling of remaining vacant storage space with special concrete, concrete lining of the repository caverns, sealing of access tunnels on final closure of the repository. Natural geological safety barriers - host rock and overlying formations - have the following important functions. Because of its stability, the host rock in the repository zone protects the technical safety barrier system from destruction caused by climatic effects and erosion for a sufficient length of time. It also provides for low water flow and favourable chemistry (reducing conditions)

  1. Testing Convergence of Different Free-Energy Methods in a Simple Analytical System with Hidden Barriers

    Directory of Open Access Journals (Sweden)

    S. Alexis Paz

    2018-03-01

    Full Text Available In this work, we study the influence of hidden barriers on the convergence behavior of three free-energy calculation methods: well-tempered metadynamics (WTMD, adaptive-biasing forces (ABF, and on-the-fly parameterization (OTFP. We construct a simple two-dimensional potential-energy surfaces (PES that allows for an exact analytical result for the free-energy in any one-dimensional order parameter. Then we chose different CV definitions and PES parameters to create three different systems with increasing sampling challenges. We find that all three methods are not greatly affected by the hidden-barriers in the simplest case considered. The adaptive sampling methods show faster sampling while the auxiliary high-friction requirement of OTFP makes it slower for this case. However, a slight change in the CV definition has a strong impact in the ABF and WTMD performance, illustrating the importance of choosing suitable collective variables.

  2. Breakup mechanisms for 7Li + 197Au, 204Pb systems at sub-barrier energies

    Directory of Open Access Journals (Sweden)

    Luong D.H.

    2013-12-01

    Full Text Available Coincidence measurements of breakup fragments were carried out for the 7Li + 197Au and 204Pb systems at sub-barrier energies. The mechanisms triggering breakup, and time-scales of each process, were identified through the reaction Q-values and the relative energy of the breakup fragments. Binary breakup of 7Li were found to be predominantly triggered by nucleon transfer, with p-pickup leading to 8Be → α + α decay being the preferred breakup mode. From the time-scales of each process, the coincidence yields were separated into prompt and delayed components, allowing the identification of breakup process important in the suppression of complete fusion of 7Li at above-barrier energies.

  3. Effects of sea-level rise on barrier island groundwater system dynamics: ecohydrological implications

    Science.gov (United States)

    Masterson, John P.; Fienen, Michael N.; Thieler, E. Robert; Gesch, Dean B.; Gutierrez, Benjamin T.; Plant, Nathaniel G.

    2014-01-01

    We used a numerical model to investigate how a barrier island groundwater system responds to increases of up to 60 cm in sea level. We found that a sea-level rise of 20 cm leads to substantial changes in the depth of the water table and the extent and depth of saltwater intrusion, which are key determinants in the establishment, distribution and succession of vegetation assemblages and habitat suitability in barrier islands ecosystems. In our simulations, increases in water-table height in areas with a shallow depth to water (or thin vadose zone) resulted in extensive groundwater inundation of land surface and a thinning of the underlying freshwater lens. We demonstrated the interdependence of the groundwater response to island morphology by evaluating changes at three sites. This interdependence can have a profound effect on ecosystem composition in these fragile coastal landscapes under long-term changing climatic conditions.

  4. Implementation of Computer Assisted Test Selection System in Local Governments

    Directory of Open Access Journals (Sweden)

    Abdul Azis Basri

    2016-05-01

    Full Text Available As an evaluative way of selection of civil servant system in all government areas, Computer Assisted Test selection system was started to apply in 2013. In phase of implementation for first time in all areas in 2014, this system selection had trouble in several areas, such as registration procedure and passing grade. The main objective of this essay was to describe implementation of new selection system for civil servants in the local governments and to seek level of effectiveness of this selection system. This essay used combination of study literature and field survey which data collection was made by interviews, observations, and documentations from various sources, and to analyze the collected data, this essay used reduction, display data and verification for made the conclusion. The result of this essay showed, despite there a few parts that be problem of this system such as in the registration phase but almost all phases of implementation of CAT selection system in local government areas can be said was working clearly likes in preparation, implementation and result processing phase. And also this system was fulfilled two of three criterias of effectiveness for selection system, they were accuracy and trusty. Therefore, this selection system can be said as an effective way to select new civil servant. As suggestion, local governments have to make prime preparation in all phases of test and make a good feedback as evaluation mechanism and together with central government to seek, fix and improve infrastructures as supporting tool and competency of local residents.

  5. Some Danish experience with product-service systems and their potentials and barriers to sustainable development

    DEFF Research Database (Denmark)

    Jørgensen, Michael Søgaard

    2003-01-01

    This paper is one of the first attempts to scan the Danish experience with product-service systems and analyse the experiences with respect to potentials and barriers to sustainable development, i.e. reduced resource consumption and reduced environmental impact. The scan shows a variety of product-service-systems......: some have been around for many years and have not be set up for sustainability purposes, while others are rather new and are attempts to contribute to a more sustainable development. Some of the systems identified are so to say born as product-service-systems (like food catering), while others have...... been developed from being a product system into being a product-service-systems in order to support the marketing of more environmental friendly products....

  6. Induction of selective blood-tumor barrier permeability and macromolecular transport by a biostable kinin B1 receptor agonist in a glioma rat model.

    Science.gov (United States)

    Côté, Jérôme; Bovenzi, Veronica; Savard, Martin; Dubuc, Céléna; Fortier, Audrey; Neugebauer, Witold; Tremblay, Luc; Müller-Esterl, Werner; Tsanaclis, Ana-Maria; Lepage, Martin; Fortin, David; Gobeil, Fernand

    2012-01-01

    Treatment of malignant glioma with chemotherapy is limited mostly because of delivery impediment related to the blood-brain tumor barrier (BTB). B1 receptors (B1R), inducible prototypical G-protein coupled receptors (GPCR) can regulate permeability of vessels including possibly that of brain tumors. Here, we determine the extent of BTB permeability induced by the natural and synthetic peptide B1R agonists, LysdesArg(9)BK (LDBK) and SarLys[dPhe(8)]desArg(9)BK (NG29), in syngeneic F98 glioma-implanted Fischer rats. Ten days after tumor inoculation, we detected the presence of B1R on tumor cells and associated vasculature. NG29 infusion increased brain distribution volume and uptake profiles of paramagnetic probes (Magnevist and Gadomer) at tumoral sites (T(1)-weighted imaging). These effects were blocked by B1R antagonist and non-selective cyclooxygenase inhibitors, but not by B2R antagonist and non-selective nitric oxide synthase inhibitors. Consistent with MRI data, systemic co-administration of NG29 improved brain tumor delivery of Carboplatin chemotherapy (ICP-Mass spectrometry). We also detected elevated B1R expression in clinical samples of high-grade glioma. Our results documented a novel GPCR-signaling mechanism for promoting transient BTB disruption, involving activation of B1R and ensuing production of COX metabolites. They also underlined the potential value of synthetic biostable B1R agonists as selective BTB modulators for local delivery of different sized-therapeutics at (peri)tumoral sites.

  7. Induction of selective blood-tumor barrier permeability and macromolecular transport by a biostable kinin B1 receptor agonist in a glioma rat model.

    Directory of Open Access Journals (Sweden)

    Jérôme Côté

    Full Text Available Treatment of malignant glioma with chemotherapy is limited mostly because of delivery impediment related to the blood-brain tumor barrier (BTB. B1 receptors (B1R, inducible prototypical G-protein coupled receptors (GPCR can regulate permeability of vessels including possibly that of brain tumors. Here, we determine the extent of BTB permeability induced by the natural and synthetic peptide B1R agonists, LysdesArg(9BK (LDBK and SarLys[dPhe(8]desArg(9BK (NG29, in syngeneic F98 glioma-implanted Fischer rats. Ten days after tumor inoculation, we detected the presence of B1R on tumor cells and associated vasculature. NG29 infusion increased brain distribution volume and uptake profiles of paramagnetic probes (Magnevist and Gadomer at tumoral sites (T(1-weighted imaging. These effects were blocked by B1R antagonist and non-selective cyclooxygenase inhibitors, but not by B2R antagonist and non-selective nitric oxide synthase inhibitors. Consistent with MRI data, systemic co-administration of NG29 improved brain tumor delivery of Carboplatin chemotherapy (ICP-Mass spectrometry. We also detected elevated B1R expression in clinical samples of high-grade glioma. Our results documented a novel GPCR-signaling mechanism for promoting transient BTB disruption, involving activation of B1R and ensuing production of COX metabolites. They also underlined the potential value of synthetic biostable B1R agonists as selective BTB modulators for local delivery of different sized-therapeutics at (peritumoral sites.

  8. Microfluidic systems with ion-selective membranes.

    Science.gov (United States)

    Slouka, Zdenek; Senapati, Satyajyoti; Chang, Hsueh-Chia

    2014-01-01

    When integrated into microfluidic chips, ion-selective nanoporous polymer and solid-state membranes can be used for on-chip pumping, pH actuation, analyte concentration, molecular separation, reactive mixing, and molecular sensing. They offer numerous functionalities and are hence superior to paper-based devices for point-of-care biochips, with only slightly more investment in fabrication and material costs required. In this review, we first discuss the fundamentals of several nonequilibrium ion current phenomena associated with ion-selective membranes, many of them revealed by studies with fabricated single nanochannels/nanopores. We then focus on how the plethora of phenomena has been applied for transport, separation, concentration, and detection of biomolecules on biochips.

  9. Asphalt emulsion radon barrier systems for uranium mill tailings: an overview of the technology

    International Nuclear Information System (INIS)

    Baker, E.G.; Hartley, J.N.; Freeman, H.D.; Gates, T.E.; Nelson, D.A.; Dunning, R.L.

    1984-03-01

    Pacific Northwest Laboratory (PNL), under contract to the US Department of Energy (DOE) Uranium Mill Tailings Remedial Action Project (UMTRAP) office, has developed an asphalt emulsion cover system to reduce the release of radon from uranium mill tailings. The system has been field tested at Grand Junction, Colorado. Results from laboratory and field tests indicate that this system is effective in reducing radon release to near-background levels ( -2 s -1 ) and has the properties required for long-term effectiveness and stability. Engineering specifications have been developed, and analysis indicates that asphalt emulsion covers are cost-competitive with other cover systems. This report summarizes the technology for asphalt emulsion radon barrier systems. 59 references, 45 figures, 36 tables

  10. Asphalt emulsion radon barrier systems for uranium mill tailings: an overview of the technology

    Energy Technology Data Exchange (ETDEWEB)

    Baker, E.G.; Hartley, J.N.; Freeman, H.D.; Gates, T.E.; Nelson, D.A.; Dunning, R.L.

    1984-03-01

    Pacific Northwest Laboratory (PNL), under contract to the US Department of Energy (DOE) Uranium Mill Tailings Remedial Action Project (UMTRAP) office, has developed an asphalt emulsion cover system to reduce the release of radon from uranium mill tailings. The system has been field tested at Grand Junction, Colorado. Results from laboratory and field tests indicate that this system is effective in reducing radon release to near-background levels (<2.5 pCi m/sup -2/s/sup -1/) and has the properties required for long-term effectiveness and stability. Engineering specifications have been developed, and analysis indicates that asphalt emulsion covers are cost-competitive with other cover systems. This report summarizes the technology for asphalt emulsion radon barrier systems. 59 references, 45 figures, 36 tables.

  11. Overcoming barriers to electronic medical record (EMR) implementation in the US healthcare system: A comparative study.

    Science.gov (United States)

    Kumar, Sameer; Aldrich, Krista

    2010-12-01

    An EMR system implementation would significantly reduce clinician workload and medical errors while saving the US healthcare system major expense. Yet, compared to other developed nations, the US lags behind. This article examines EMR system efforts, benefits, and barriers, as well as steps needed to move the US closer to a nationwide EMR system. The analysis includes a blueprint for implementation of EMR, industry comparisons to highlight the differences between successful and non-successful EMR ventures, references to costs and benefit information, and identification of root causes. 'Poka-yokes' (avoid (yokeru) mistakes (poka)) will be inserted to provide insight into how to systematically overcome challenges. Implementation will require upfront costs including patient privacy that must be addressed early in the development process. Government structure, incentives and mandates are required for nationwide EMR system in the US.

  12. Studies on an advanced repository system with enhanced engineered barriers (a framework)

    International Nuclear Information System (INIS)

    Fujiwara, A.; Tashiro, S.; Ikari, S.; Suzuki, A.

    1993-01-01

    In order to propose advanced designs of repositories with enhanced engineered barriers of relatively high radioactive wastes such as burnable poisons, channel boxes, control rods and highly irradiated metals, studies started in 1987 and completed the first phase in 1992. This paper presents the framework and brief results of the first phase. The studies set preliminary design concepts of the repositories with various combinations with engineered barriers and natural barriers for different models and locations such as a silo type in shallow land or a tunnel type in intermediate depth. Through the designs, four component technics were picked up and studied for (1) construction of the components in repository; (2) performance evaluation to realize repository design; (3) improvement of circumstances inside or around repository; and (4) surveillance of repository performance to realize the repository designs. Finally, some repository systems were provided using obtained results, and then the applicability and the economy were evaluated. The studies will continue to the second phase focusing on the long-term performance of the repositories

  13. Implementing a Lean Management System in Primary Care: Facilitators and Barriers From the Front Lines.

    Science.gov (United States)

    Hung, Dorothy; Martinez, Meghan; Yakir, Maayan; Gray, Caroline

    2015-01-01

    Although Lean management techniques are increasingly used in health care to improve quality and reduce costs, lessons about how to successfully implement this approach on the front lines of care delivery are not well documented. In this study, we highlight key facilitators and barriers to implementing Lean among frontline primary care providers. This case study took place at a large, ambulatory care delivery system serving nearly 1 million patients. In-depth interviews were conducted with primary care physicians, staff, and administrators to identify key factors impacting Lean redesigns in primary care. Overall, staff engagement and performance management, sensitivity to the professional values and culture of medicine, and perceived adequacy of organizational resources were critical when introducing Lean changes. Specific drivers of change included empowerment of staff at all levels, visual display of performance metrics, and a culture of innovation and collaboration. Barriers included physician resistance to standardized work, difficulty transferring management responsibilities to non-physician staff, and time and staffing required for participating in improvement efforts. Although Lean offers a new approach to delivering care, the implementation process itself is both complex and crucial to success. Understanding early facilitators and barriers can maximize Lean's, potential to improve health care delivery.

  14. Monitoring long-term evolution of engineered barrier systems using magnets: Magnetic response.

    Science.gov (United States)

    Rigonat, N; Isnard, O; Harley, S L; Butler, I B

    2018-01-05

    Remote and non-destructive monitoring of the stability and performance of Engineered Barrier Systems for Geological Disposal Facility of is gaining considerable importance in establishing the safety cases for Higher Activity Wastes disposal. This study offers an innovative use of mineral magnetism for monitoring groundwater saturation of the barrier. Four mixtures of permanent magnets (Nd-Fe-B, coated and uncoated; SmCo and AlNiCo) and bentonite were reacted for 4, 8 and 12 months with mildly-saline, high-pH leachates, representing the fluids saturating a time-evolved engineered barrier. Coupled hysteresis and thermomagnetic analyses demonstrate how Nd-Fe-B feature a time-dependent transition from square-like ferromagnetic to superparamagnetic loop via pot-bellied and wasp-waist loops, whereas SmCo and AlNiCo do not show so extensive corrosion-related variations of the intrinsic and extrinsic magnetic properties. This study allowed to identify magnetic materials suitable for shorter- (Nd-Fe-B) and longer-term (SmCo and AlNiCo) monitoring purposes. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  15. Interorganisational Integration: Healthcare Professionals’ Perspectives on Barriers and Facilitators within the Danish Healthcare System

    Directory of Open Access Journals (Sweden)

    Anne Marie Lyngsø

    2016-03-01

    Full Text Available Introduction: Despite many initiatives to improve coordination of patient pathways and intersectoral cooperation, Danish health care is still fragmented, lacking intra- and interorganisational integration. This study explores barriers to and facilitators of interorganisational integration as perceived by healthcare professionals caring for patients with chronic obstructive pulmonary disease within the Danish healthcare system. Methods: Seven focus groups were conducted in January through July 2014 with 21 informants from general practice, local healthcare centres and a pulmonary department at a university hospital in the Capital Region of Denmark. Results and discussion: Our results can be grouped into five influencing areas for interorganisational integration: communication/information transfer, committed leadership, patient engagement, the role and competencies of the general practitioner and organisational culture. Proposed solutions to barriers in each area hold the potential to improve care integration as experienced by individuals responsible for supporting and facilitating it. Barriers and facilitators to integrating care relate to clinical, professional, functional and normative integration. Especially, clinical, functional and normative integration seems fundamental to developing integrated care in practice from the perspective of healthcare professionals.

  16. Fission Meter Information Barrier Attribute Measurement System: Task 1 Report: Document existing Fission Meter neutron IB system

    Energy Technology Data Exchange (ETDEWEB)

    Kerr, P. L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-02-28

    An SNM attribute Information Barrier (IB) system was developed for a 2011 US/UK Exercise. The system was modified and extensively tested in a 2013-2014 US-UK Measurement Campaign. This work demonstrated rapid deployment of an IB system for potential treaty use. The system utilizes an Ortec Fission Meter neutron multiplicity counter and custom computer code. The system demonstrates a proof-of-principle automated Pu-240 mass determination with an information barrier. After a software start command is issued, the system automatically acquires and downloads data, performs an analysis, and displays the results. This system conveys the results of a Pu mass threshold measurements in a way the does not reveal sensitive information. In full IB mode, only red/green ‘lights’ are displayed in the software. In test mode, more detailed information is displayed. The code can also read in, analyze, and display results from previously acquired or simulated data. Because the equipment is commercial-off-the-shelf (COTS), the system demonstrates a low-cost short-lead-time technology for treaty SNM attribute measurements. A deployed system will likely require integration of additional authentication and tamper-indicating technologies. This will be discussed for the project in this and future progress reports.

  17. [Wavelength Selection in Hemolytic Evaluation Systems with Spectrophotometry Detection].

    Science.gov (United States)

    Zhang, Hong; Su, Baochang; Ye, Xunda; Luo, Man

    2016-04-01

    Spectrophotometry is a simple hemolytic evaluation method commonly used in new drugs,biomedical materials and blood products.It is for the quantitative analysis of the characteristic absorption peaks of hemoglobin.Therefore,it is essential to select the correct detection wavelength when the evaluation system has influences on the conformation of hemoglobin.Based on the study of changes in the characteristic peaks over time of the hemolysis supernatant in four systems,namely,cell culture medium,phosphate buffered saline(PBS),physiological saline and banked blood preservation solution,using continuous wavelength scanning,the selections of detection wavelength were proposed as follows.In the cell culture medium system,the wavelength of 415 nm should be selected within 4h;,near 408 nm should be selected within 4~72h.In PBS system,within 4h,541 nm,577nm or 415 nm should be selected;4~72h,541 nm,577nm or near 406 nm should be selected.In physiological saline system,within 4h,414 nm should be selected;4~72h,near 405 nm should be selected;within 12 h,541nm or 577 nm could also be selected.In banked blood preservation solution system,within 72 h,415nm,540 nm or 576 nm should be selected.

  18. Understanding the modifiable health systems barriers to hypertension management in Malaysia: a multi-method health systems appraisal approach.

    Science.gov (United States)

    Risso-Gill, Isabelle; Balabanova, Dina; Majid, Fadhlina; Ng, Kien Keat; Yusoff, Khalid; Mustapha, Feisul; Kuhlbrandt, Charlotte; Nieuwlaat, Robby; Schwalm, J-D; McCready, Tara; Teo, Koon K; Yusuf, Salim; McKee, Martin

    2015-07-03

    The growing burden of non-communicable diseases in middle-income countries demands models of care that are appropriate to local contexts and acceptable to patients in order to be effective. We describe a multi-method health system appraisal to inform the design of an intervention that will be used in a cluster randomized controlled trial to improve hypertension control in Malaysia. A health systems appraisal was undertaken in the capital, Kuala Lumpur, and poorer-resourced rural sites in Peninsular Malaysia and Sabah. Building on two systematic reviews of barriers to hypertension control, a conceptual framework was developed that guided analysis of survey data, documentary review and semi-structured interviews with key informants, health professionals and patients. The analysis followed the patients as they move through the health system, exploring the main modifiable system-level barriers to effective hypertension management, and seeking to explain obstacles to improved access and health outcomes. The study highlighted the need for the proposed intervention to take account of how Malaysian patients seek treatment in both the public and private sectors, and from western and various traditional practitioners, with many patients choosing to seek care across different services. Patients typically choose private care if they can afford to, while others attend heavily subsidised public clinics. Public hypertension clinics are often overwhelmed by numbers of patients attending, so health workers have little time to engage effectively with patients. Treatment adherence is poor, with a widespread belief, stemming from concepts of traditional medicine, that hypertension is a transient disturbance rather than a permanent asymptomatic condition. Drug supplies can be erratic in rural areas. Hypertension awareness and education material are limited, and what exist are poorly developed and ineffective. Despite having a relatively well funded health system offering good access to

  19. Method for Business Process Management System Selection

    NARCIS (Netherlands)

    Thijs van de Westelaken; Bas Terwee; Pascal Ravesteijn

    2013-01-01

    In recent years business process management (BPM) and specifically information systems that support the analysis, design and execution of processes (also called business process management systems (BPMS)) are getting more attention. This has lead to an increase in research on BPM and BPMS. However

  20. Development of a coincidence system for radio-nuclide standardization using surface barrier detectors

    International Nuclear Information System (INIS)

    Koskinas, M.F.

    1988-01-01

    A system for the standardization of alpha-gamma or electron-X radionuclide emitters has been developed in the present work. The system consists of one or two surface barrier detectors for alpha or electron detection which are coupled to thin-window NaI (T1) crystals suitable for low energy X or gamma ray detection. The performance of the system has been verified by means of the standardization of 241 Am, 137 Cs and 109 Cd solutions. The activity has been obtained using the extrapolation method applied to the 4Πα-γ and 2Πe c -X coincidence technique. The surface barrier detection efficiency was varied by placing absorbers over the radioactive sources or by changing the source to detector distance. The results were compared to those obtained using conventional absolute systems based on gas-flow and pressurized 4Π proportional counters, or using radioactive solutions standardized in international comparisons spondored by the Bureau International des Poids et Mesures. The expect and measured activities agree within the experimental uncertainties which were: 0.2 % for 241 Am, 0.7% for 137 Cs and 0.6% for 109 Cd. The ratio between the probabilities of (electron capture + internal conversion) and internal conversion for the K-shell of 109 Cd has been determined. The result is: 2.8883 ± 0.016. (author) [pt

  1. Combined photovoltaic and solar-thermal systems: overcoming barriers to market acceptance

    International Nuclear Information System (INIS)

    Collins, M.R.

    2005-01-01

    Combined Photovoltaic and Solar-Thermal Systems (PV/T Systems) combine Photovoltaic (PV) and solar thermal technologies into one system with both electrical and thermal energy output. PV/T systems have several perceived advantages to stand-alone PV or solar-thermal systems. The increased efficiency and dual nature of the systems make suitable for situations where installation space is limited, and for homeowners who are forced to decide between meeting thermal or electrical needs. The financial benefit of the combined system is also significant, as the long payback of PV systems is joined with a relatively short payback of solar thermal systems. A background of PV/T was presented, with details of classifications and the International Energy Association's program to evaluate the technical status of PV/T systems and formulate a roadmap for future development. It was noted that input from the Solar Heating and Cooling Program (SHCP) is needed to help identify market barriers in PV/T systems. This paper reviewed existing and potential PV/T systems and their technical status, and reported on the methodology established by IEA group 35. The systems were grouped according to thermal collector types of unglazed water collectors, glazed water collectors, unglazed air collectors, glazed air collectors, air-flow windows, and concentrating collectors. It was noted that a number of new systems are currently being developed, including concentrating collectors with water and air heating, unglazed air heating systems, and unglazed water heating systems. It was noted that apart from technical barriers, efficient design and performance prediction are also problematic, as tools for predicting performance do not exist. The same tools will be used to optimize PV/T system designs. It was suggested that standardized reporting methods, simulation and sizing tools and demonstration products need to be created and that regional certification issues need to be identified. Environmental

  2. Select PC/windows flat to develop data acquisition system

    International Nuclear Information System (INIS)

    Zhang Jin

    1993-01-01

    Through needing analysis, and also, considering user's ability of payment, the characteristic of China computer market, the computer developing tending, and the system's compatibility and up grade capability, PC/Windows flat are selected to develop a data acquisition system

  3. Selection of nuclear power information database management system

    International Nuclear Information System (INIS)

    Zhang Shuxin; Wu Jianlei

    1996-01-01

    In the condition of the present database technology, in order to build the Chinese nuclear power information database (NPIDB) in the nuclear industry system efficiently at a high starting point, an important task is to select a proper database management system (DBMS), which is the hinge of the matter to build the database successfully. Therefore, this article explains how to build a practical information database about nuclear power, the functions of different database management systems, the reason of selecting relation database management system (RDBMS), the principles of selecting RDBMS, the recommendation of ORACLE management system as the software to build database and so on

  4. Professional perspectives on systemic barriers to admission avoidance: learning from a system dynamics study of older people's admission pathways.

    Science.gov (United States)

    Walsh, Bronagh; Lattimer, Valerie; Wintrup, Julie; Brailsford, Sally

    2015-06-01

    There is debate worldwide about the best way to manage increased healthcare demand within ageing populations, particularly rising rates of unplanned and avoidable hospital admissions. To understand health and social care professionals' perspectives on barriers to admission avoidance throughout the admissions journey, in particular: the causes of avoidable admissions in older people; drivers of admission and barriers to use of admission avoidance strategies; and improvements to reduce unnecessary admissions. A qualitative framework analysis of interview data from a System dynamics (SD) modelling study. Semi-structured interviews were conducted with twenty health and social care professionals with experience of older people's admissions. The interviews were used to build understanding of factors facilitating or hindering admission avoidance across the admissions system. Data were analysed using framework analysis. Three overarching themes emerged: understanding the needs of the patient group; understanding the whole system; and systemwide access to expertise in care of older people. There were diverse views on the underlying reasons for avoidable admissions and recognition of the need for whole-system approaches to service redesign. Participants recommended system redesign that recognises the specific needs of older people, but there was no consensus on underlying patient needs or specific service developments. Access to expertise in management of older and frailer patients was seen as a barrier to admission avoidance throughout the system. Providing access to expertise and leadership in care of frail older people across the admissions system presents a challenge for service managers and nurse educators but is seen as a prerequisite for effective admission avoidance. System redesign to meet the needs of frail older people requires agreement on causes of avoidable admission and underlying patient needs. © 2014 John Wiley & Sons Ltd.

  5. Advanced Oxide Material Systems for 1650 Deg. C Thermal/Environmental Barrier Coating Applications

    National Research Council Canada - National Science Library

    Zhu, Dongming; Fox, Dennis S; Bansal, Narottam P; Miller, Robert A

    2004-01-01

    ... systems under engine high-heat-flux and severe thermal cycling conditions. In this report, the thermal conductivity and water vapor stability of selected candidate hafnia-, pyrochlore-, and magnetoplumbite-based TEBC materials are evaluated...

  6. Planar dynamical systems selected classical problems

    CERN Document Server

    Liu, Yirong; Huang, Wentao

    2014-01-01

    This book presents in an elementary way the recent significant developments in the qualitative theory of planar dynamical systems. The subjects are covered as follows: the studies of center and isochronous center problems, multiple Hopf bifurcations and local and global bifurcations of the equivariant planar vector fields which concern with Hilbert's 16th problem. This book is intended for graduate students, post-doctors and researchers in the area of theories and applications of dynamical systems. For all engineers who are interested the theory of dynamical systems, it is also a reasona

  7. Multiuser hybrid switched-selection diversity systems

    KAUST Repository

    Shaqfeh, Mohammad; Alnuweiri, Hussein M.; Alouini, Mohamed-Slim

    2011-01-01

    system provides flexibility in trading-off the channel information feedback overhead with the prospected multiuser diversity gains. The users are clustered into groups, and the users' groups are ordered into a sequence. Per-group feedback thresholds

  8. ATTENTIONAL NETWORKS AND SELECTIVE VISUAL SYSTEM

    Directory of Open Access Journals (Sweden)

    ALEJANDRO CASTILLO MORENO

    2006-05-01

    Full Text Available In this paper we checked the principal researches and theories to explain the attention system functioning.We are going to start reviewing along time about the concept of attention, from filter theories andresources distributor theories, to the current theories in which attention is conceived as a control system.From this last point of view, we will emphasize on the attentional networks theory of Posner, thatproposes different systems to explain diverse aspects of attention, but they are related to each other. Atlast in this paper, we will mention experimental results that have been important to characterize theselective attentional mechanisms of the human visual system, using the attentional spotlight model forthis aim.

  9. Computerized adaptive testing item selection in computerized adaptive learning systems

    NARCIS (Netherlands)

    Eggen, Theodorus Johannes Hendrikus Maria; Eggen, T.J.H.M.; Veldkamp, B.P.

    2012-01-01

    Item selection methods traditionally developed for computerized adaptive testing (CAT) are explored for their usefulness in item-based computerized adaptive learning (CAL) systems. While in CAT Fisher information-based selection is optimal, for recovering learning populations in CAL systems item

  10. The system of employees motivation in a selected company

    OpenAIRE

    BEEROVÁ, Petra

    2014-01-01

    The system of employees motivation in a selected company is the title of this thesis that closely analyzes the system of employees motivation in a selected company and outlines some suggestions that could improve the management and performance in this area. Moreover, the focus is placed towards the motivation of employees in the workplace.

  11. Engineered barrier systems and canister orientation studies for the Yucca Mountain Project, Nevada

    International Nuclear Information System (INIS)

    Wilder, D.G.

    1990-07-01

    Emplacement borehole orientation directly impacts many aspects of the Engineered Barrier System (EBS) and interactions with the near field environment. This paper considers the impacts of orientation on the hydrologic portion of the environment and its interactions with the EBS. The hydrologic environments is considered from a conceptual standpoint, the numerical analyses are left for subsequent work. As reported in this paper, several aspects of the hydrological environment are more favorable for long term performance of vertically oriented rather than horizontally oriented Waste Packages. 19 refs., 15 figs

  12. Waste form performance assessment in the YUCCA Mountain engineered barrier system, American Nuclear Society

    International Nuclear Information System (INIS)

    Morris, E. E.; Fanning, T. H.; Wigeland, R. A.

    2000-01-01

    This work demonstrates a technique for comparing the performance of waste forms in a repository environment when one or more of the waste forms constitute a small part of the total amount of waste planned for the repository. In applying the technique, it is important to identify radionuclides that are highly soluble in the transport fluid since it is only for these that the release is controlled by the dissolution rate of the waste form matrix. The techniques presented here have been applied to an evaluation of the performance of waste forms from the electrometallurgical treatment of spent fuel in the proposed Yucca Mountain Repository Engineered Barrier System (EBS)

  13. Nanofiber-based filters as novel barrier systems for nanomaterial exposure scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Faccini, M; Amantia, D; Vazquez-Campos, S; Aubouy, L [LEITAT Technological Center, Passeig 22 de Juliol, 218, 08221 Terrassa (Spain); Vaquero, C; Lopez de Ipina, J M, E-mail: mfaccini@leitat.org [Tecnalia, P.T. Alava - C/ Leonardo Da Vinci, 11, 01510 Minano (Alava) (Spain)

    2011-07-06

    In this article our latest advances in the development of efficient barrier systems against micro- and nano-particulate materials are presented. Nanofibrous polyamide 6 (PA6) mats were fabricated by electrospinning onto a nonwoven viscose substrate. The influence of electrospinning parameters including solution concentration, viscosity, and conductivity, were studied for the production of nonwovens with different fiber size distribution ranging from 74 to 261 nm in diameters. Moreover, the formation of nanowebs (30-40 nm) which are widely distributed among fibers was observed. By varying several process parameters, membranes with different thickness of the nanofiber layer and therefore air permeability and nanoparticle filtration efficiency were obtained.

  14. Engineered barrier system and waste package design concepts for a potential geologic repository at Yucca Mountain

    International Nuclear Information System (INIS)

    Short, D.W.; Ruffner, D.J.; Jardine, L.J.

    1991-10-01

    We are using an iterative process to develop preliminary concept descriptions for the Engineered Barrier System and waste-package components for the potential geologic repository at Yucca Mountain. The process allows multiple design concepts to be developed subject to major constraints, requirements, and assumptions. Involved in the highly interactive and interdependent steps of the process are technical specialists in engineering, metallic and nonmetallic materials, chemistry, geomechanics, hydrology, and geochemistry. We have developed preliminary design concepts that satisfy both technical and nontechnical (e.g., programmatic or policy) requirements

  15. Burden of Circulatory System Diseases and Ignored Barriers ofKnowledge Translation

    Directory of Open Access Journals (Sweden)

    Hamed-Basir Ghafouri

    2012-10-01

    Full Text Available Circulatory system disease raise third highest disability-adjusted life years among Iranians and ischemic cardiac diseases are main causes for such burden. Despite available evidences on risk factors of the disease, no effective intervention was implemented to control and prevent the disease. This paper non-systematically reviews available literature on the problem, solutions, and barriers of implementation of knowledge translation in Iran. It seems that there are ignored factors such as cultural and motivational issues in knowledge translation interventions but there are hopes for implementation of started projects and preparation of students as next generation of knowledge transferors.

  16. OVERCOMING THE METER BARRIER AND THE FORMATION OF SYSTEMS WITH TIGHTLY PACKED INNER PLANETS (STIPs)

    International Nuclear Information System (INIS)

    Boley, A. C.; Morris, M. A.; Ford, E. B.

    2014-01-01

    We present a solution to the long outstanding meter barrier problem in planet formation theory. As solids spiral inward due to aerodynamic drag, they will enter disk regions that are characterized by high temperatures, densities, and pressures. High partial pressures of rock vapor can suppress solid evaporation, and promote collisions between partially molten solids, allowing rapid growth. This process should be ubiquitous in planet-forming disks, which may be evidenced by the abundant class of Systems with Tightly packed Inner Planets discovered by the NASA Kepler Mission

  17. Reactive Transport and Coupled THM Processes in Engineering Barrier Systems (EBS)

    International Nuclear Information System (INIS)

    Steefel, Carl; Rutqvist, Jonny; Tsang, Chin-Fu; Liu, Hui-Hai; Sonnenthal, Eric; Houseworth, Jim; Birkholzer, Jens

    2010-01-01

    Geological repositories for disposal of high-level nuclear wastes generally rely on a multi-barrier system to isolate radioactive wastes from the biosphere. The multi-barrier system typically consists of a natural barrier system, including repository host rock and its surrounding subsurface environment, and an engineering barrier system (EBS). EBS represents the man-made, engineered materials placed within a repository, including the waste form, waste canisters, buffer materials, backfill and seals (OECD, 2003). EBS plays a significant role in the containment and long-term retardation of radionuclide release. EBS is involved in complex thermal, hydrogeological, mechanical, chemical and biological processes, such as heat release due to radionuclide decay, multiphase flow (including gas release due to canister corrosion), swelling of buffer materials, radionuclide diffusive transport, waste dissolution and chemical reactions. All these processes are related to each other. An in-depth understanding of these coupled processes is critical for the performance assessment (PA) for EBS and the entire repository. Within the EBS group of Used Fuel Disposition (UFD) Campaign, LBNL is currently focused on (1) thermal-hydraulic-mechanical-chemical (THMC) processes in buffer materials (bentonite) and (2) diffusive transport in EBS associated with clay host rock, with a long-term goal to develop a full understanding of (and needed modeling capabilities to simulate) impacts of coupled processes on radionuclide transport in different components of EBS, as well as the interaction between near-field host rock (e.g., clay) and EBS and how they effect radionuclide release. This final report documents the progress that LBNL has made in its focus areas. Specifically, Section 2 summarizes progress on literature review for THMC processes and reactive-diffusive radionuclide transport in bentonite. The literature review provides a picture of the state-of-the-art of the relevant research areas

  18. Reactive Transport and Coupled THM Processes in Engineering Barrier Systems (EBS)

    Energy Technology Data Exchange (ETDEWEB)

    Steefel, Carl; Rutqvist, Jonny; Tsang, Chin-Fu; Liu, Hui-Hai; Sonnenthal, Eric; Houseworth, Jim; Birkholzer, Jens

    2010-08-31

    Geological repositories for disposal of high-level nuclear wastes generally rely on a multi-barrier system to isolate radioactive wastes from the biosphere. The multi-barrier system typically consists of a natural barrier system, including repository host rock and its surrounding subsurface environment, and an engineering barrier system (EBS). EBS represents the man-made, engineered materials placed within a repository, including the waste form, waste canisters, buffer materials, backfill and seals (OECD, 2003). EBS plays a significant role in the containment and long-term retardation of radionuclide release. EBS is involved in complex thermal, hydrogeological, mechanical, chemical and biological processes, such as heat release due to radionuclide decay, multiphase flow (including gas release due to canister corrosion), swelling of buffer materials, radionuclide diffusive transport, waste dissolution and chemical reactions. All these processes are related to each other. An in-depth understanding of these coupled processes is critical for the performance assessment (PA) for EBS and the entire repository. Within the EBS group of Used Fuel Disposition (UFD) Campaign, LBNL is currently focused on (1) thermal-hydraulic-mechanical-chemical (THMC) processes in buffer materials (bentonite) and (2) diffusive transport in EBS associated with clay host rock, with a long-term goal to develop a full understanding of (and needed modeling capabilities to simulate) impacts of coupled processes on radionuclide transport in different components of EBS, as well as the interaction between near-field host rock (e.g., clay) and EBS and how they effect radionuclide release. This final report documents the progress that LBNL has made in its focus areas. Specifically, Section 2 summarizes progress on literature review for THMC processes and reactive-diffusive radionuclide transport in bentonite. The literature review provides a picture of the state-of-the-art of the relevant research areas

  19. Overcoming barriers to implementation of evidence-based practice concepts in athletic training education: perceptions of select educators.

    Science.gov (United States)

    Manspeaker, Sarah; Van Lunen, Bonnie

    2011-01-01

    The need to include evidence-based practice (EBP) concepts in entry-level athletic training education is evident as the profession transitions toward using evidence to inform clinical decision making. To evaluate athletic training educators' experience with implementation of EBP concepts in Commission on Accreditation of Athletic Training Education (CAATE)-accredited entry-level athletic training education programs in reference to educational barriers and strategies for overcoming these barriers. Qualitative interviews of emergent design with grounded theory. Undergraduate CAATE-accredited athletic training education programs. Eleven educators (3 men, 8 women). The average number of years teaching was 14.73 ± 7.06. Interviews were conducted to evaluate perceived barriers and strategies for overcoming these barriers to implementation of evidence-based concepts in the curriculum. Interviews were explored qualitatively through open and axial coding. Established themes and categories were triangulated and member checked to determine trustworthiness. Educators identified 3 categories of need for EBP instruction: respect for the athletic training profession, use of EBP as part of the decision-making toolbox, and third-party reimbursement. Barriers to incorporating EBP concepts included time, role strain, knowledge, and the gap between clinical and educational practices. Suggested strategies for surmounting barriers included identifying a starting point for inclusion and approaching inclusion from a faculty perspective. Educators must transition toward instruction of EBP, regardless of barriers present in their academic programs, in order to maintain progress with other health professions' clinical practices and educational standards. Because today's students are tomorrow's clinicians, we need to include EBP concepts in entry-level education to promote critical thinking, inspire potential research interest, and further develop the available body of knowledge in our

  20. Reviews of the In-situ Demonstration Test of the Engineered Barrier System in Many Countries

    International Nuclear Information System (INIS)

    Lee, Minsoo; Choi, Heui Joo

    2013-01-01

    Many nations considering the deep geologic disposal of HLW are now planning or executing in-situ demonstration experiments on their regional EBS (Engineering barrier system) at their deep underground research facilities. The main purpose of the in-situ EBS test is the experimental confirmation of its performance, and the prediction of its long-term evolution through the modeling of EBS based on the experimental data. Additionally, the engineering feasibility for the construction of an engineering barrier system can also be checked through full scale construction of an in-situ test. KAERI is currently preparing an in-situ test at a large 1/3 scale, called IN-DEBS (In-situ Demonstration of EBS) at KURT (KAERI Underground Research Tunnel) for the generic EBS suggested in A-KRS (Advanced KAERI Reference System), which was developed to treat the HLW from pyroprocessing. As the first step for the design of IN-DEBS, the foreign in-situ demonstrations of EBS were reviewed in this paper. The demonstration projects, which were completed or are still being executed in some countries such as Sweden, France, Finland, Canada, Belgium, Switzerland, Spain, and Japan, were surveyed and summarized. In particular, hardware constitutions such as the heating element or compact bentonite, and the experimental procedures, have focused more on reviews than on experimental results in this survey, since their hardware information is very important for the design of the IN-DEBS

  1. Reviews of the In-situ Demonstration Test of the Engineered Barrier System in Many Countries

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Minsoo; Choi, Heui Joo [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2013-10-15

    Many nations considering the deep geologic disposal of HLW are now planning or executing in-situ demonstration experiments on their regional EBS (Engineering barrier system) at their deep underground research facilities. The main purpose of the in-situ EBS test is the experimental confirmation of its performance, and the prediction of its long-term evolution through the modeling of EBS based on the experimental data. Additionally, the engineering feasibility for the construction of an engineering barrier system can also be checked through full scale construction of an in-situ test. KAERI is currently preparing an in-situ test at a large 1/3 scale, called IN-DEBS (In-situ Demonstration of EBS) at KURT (KAERI Underground Research Tunnel) for the generic EBS suggested in A-KRS (Advanced KAERI Reference System), which was developed to treat the HLW from pyroprocessing. As the first step for the design of IN-DEBS, the foreign in-situ demonstrations of EBS were reviewed in this paper. The demonstration projects, which were completed or are still being executed in some countries such as Sweden, France, Finland, Canada, Belgium, Switzerland, Spain, and Japan, were surveyed and summarized. In particular, hardware constitutions such as the heating element or compact bentonite, and the experimental procedures, have focused more on reviews than on experimental results in this survey, since their hardware information is very important for the design of the IN-DEBS.

  2. Barriers to Implementing a Reporting and Learning Patient Safety System: Pediatric Chiropractic Perspective.

    Science.gov (United States)

    Pohlman, Katherine A; Carroll, Linda; Hartling, Lisa; Tsuyuki, Ross T; Vohra, Sunita

    2016-04-01

    A reporting and learning system is a method of monitoring the occurrence of incidents that affect patient safety. This cross-sectional survey asked pediatric chiropractors about factors that may limit their participation in such a system. The list of potential barriers for participation was developed using a systematic approach. All members of the 2 pediatric councils associated with US national chiropractic organizations were invited to complete the survey (N = 400). The cross-sectional survey was created using an online survey tool (REDCap) and sent directly to member emails addressed by the respective executive committees. Of the 400 potential respondents, 81 responded (20.3%). The most common limitations to participating were identified as time pressure (96%) and patient concerns (81%). Reporting and learning systems have been utilized to increase safety awareness in many high-risk industries. To be successful, future patient safety studies with pediatric chiropractors need to ensure these barriers are understood and addressed. © The Author(s) 2015.

  3. Energy barrier of bcc-fcc phase transition via the Bain path in Yukawa system

    Science.gov (United States)

    Kiyokawa, Shuji

    2018-05-01

    In the Yukawa system with the dimensionless screening parameter κ>1.5 , when bcc-fcc transition occurs via Bain path, we show that spontaneous transitions do not occur even if the system temperature reaches the transition point of bcc-fcc because it is necessary to increase once the free energy in the process of transition from bcc to fcc through Bain deformation. Here, we refer the temporary increment of the free energy during Bain deformation as Bain barrier. Since there are the Bain barriers at the transitions between bcc and fcc phases, these phases may coexist as metastable state in the wide region (not a coexistence line) of κ and the coupling constant Γ. We study the excess energy of the system and the free energy difference between bcc and fcc phases by the Monte Carlo method, where the simulation box is divided into a large number of elements with small volume and a particle in the box is restricted be placed in one of these elements. By this method, we can tabulate the values of the interparticle potential and can calculate the internal energy fast and precisely.

  4. Selected methods of rehabilitation in systemic sclerosis

    Directory of Open Access Journals (Sweden)

    Agnieszka Gerkowicz

    2017-09-01

    Full Text Available Systemic sclerosis is a chronic connective tissue disease characterized by microvascular abnormalities, immune disturbances and progressive fibrosis of the skin and internal organs. Skin involvement may result in contractures, leading to marked loss of hand mobility, adversely affecting the performance of daily activities and decreasing the quality of life. Face involvement not only causes functional loss, but also lowers the self-esteem of patients. Increasing attention has recently been focused on the need to rehabilitate patients with systemic sclerosis in order to prevent the development of joint contractures and loss of mobility. The study presents a review of the current literature on rehabilitation possibilities in patients with systemic sclerosis, with a special focus on physiotherapy methods.

  5. NPP site selection: A systems engineering approach

    Energy Technology Data Exchange (ETDEWEB)

    Pwani, Henry; Kamanja, Florah; Zolkaffly, Zulfakar; Jung, J. C. [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

    2012-10-15

    The necessity for improved decision making concerning the siting and licensing of major power facilities has been accelerated in the past decade by the increased environmental consciousness of the public and by the energy crisis. These problems are exceedingly complex due to their multiple objective nature, the many interest groups, the long range time horizons, and the inherent uncertainties of the potential impacts of any decision. Along with the relatively objective economic and engineering concerns, the more subjective factors involving safety, environmental, and social issues are crucial to the problem. The preferences of the general public, as consumers, the utility companies, as builders and operators of power plant facilities, and environmentalists and the government must be accounted for in analyzing power plant siting and licensing issues. We advocate for a systems engineering approach that articulates stake holder's requirements, expert judgements, and a systems decision making approach. The appropriateness and application of systems decision making process is illustrated in this paper.

  6. NPP site selection: A systems engineering approach

    International Nuclear Information System (INIS)

    Pwani, Henry; Kamanja, Florah; Zolkaffly, Zulfakar; Jung, J. C.

    2012-01-01

    The necessity for improved decision making concerning the siting and licensing of major power facilities has been accelerated in the past decade by the increased environmental consciousness of the public and by the energy crisis. These problems are exceedingly complex due to their multiple objective nature, the many interest groups, the long range time horizons, and the inherent uncertainties of the potential impacts of any decision. Along with the relatively objective economic and engineering concerns, the more subjective factors involving safety, environmental, and social issues are crucial to the problem. The preferences of the general public, as consumers, the utility companies, as builders and operators of power plant facilities, and environmentalists and the government must be accounted for in analyzing power plant siting and licensing issues. We advocate for a systems engineering approach that articulates stake holder's requirements, expert judgements, and a systems decision making approach. The appropriateness and application of systems decision making process is illustrated in this paper

  7. Selective Limbic Blood–Brain Barrier Breakdown in a Feline Model of Limbic Encephalitis with LGI1 Antibodies

    Science.gov (United States)

    Tröscher, Anna R.; Klang, Andrea; French, Maria; Quemada-Garrido, Lucía; Kneissl, Sibylle Maria; Bien, Christian G.; Pákozdy, Ákos; Bauer, Jan

    2017-01-01

    Human leucine-rich glioma-inactivated protein 1 encephalitis (LGI1) is an autoimmune limbic encephalitis in which serum and cerebrospinal fluid contain antibodies targeting LGI1, a protein of the voltage gated potassium channel (VGKC) complex. Recently, we showed that a feline model of limbic encephalitis with LGI1 antibodies, called feline complex partial seizures with orofacial involvement (FEPSO), is highly comparable to human LGI1 encephalitis. In human LGI1 encephalitis, neuropathological investigations are difficult because very little material is available. Taking advantage of this natural animal model to study pathological mechanisms will, therefore, contribute to a better understanding of its human counterpart. Here, we present a brain-wide histopathological analysis of FEPSO. We discovered that blood–brain barrier (BBB) leakage was present not only in all regions of the hippocampus but also in other limbic structures such as the subiculum, amygdale, and piriform lobe. However, in other regions, such as the cerebellum, no leakage was observed. In addition, this brain-region-specific immunoglobulin leakage was associated with the breakdown of endothelial tight junctions. Brain areas affected by BBB dysfunction also revealed immunoglobulin and complement deposition as well as neuronal cell death. These neuropathological findings were supported by magnetic resonance imaging showing signal and volume increase in the amygdala and the piriform lobe. Importantly, we could show that BBB disturbance in LGI1 encephalitis does not depend on T cell infiltrates, which were present brain-wide. This finding points toward another, so far unknown, mechanism of opening the BBB. The limbic predilection sites of immunoglobulin antibody leakage into the brain may explain why most patients with LGI1 antibodies have a limbic phenotype even though LGI1, the target protein, is ubiquitously distributed across the central nervous system. PMID:29093718

  8. Selective Limbic Blood–Brain Barrier Breakdown in a Feline Model of Limbic Encephalitis with LGI1 Antibodies

    Directory of Open Access Journals (Sweden)

    Anna R. Tröscher

    2017-10-01

    Full Text Available Human leucine-rich glioma-inactivated protein 1 encephalitis (LGI1 is an autoimmune limbic encephalitis in which serum and cerebrospinal fluid contain antibodies targeting LGI1, a protein of the voltage gated potassium channel (VGKC complex. Recently, we showed that a feline model of limbic encephalitis with LGI1 antibodies, called feline complex partial seizures with orofacial involvement (FEPSO, is highly comparable to human LGI1 encephalitis. In human LGI1 encephalitis, neuropathological investigations are difficult because very little material is available. Taking advantage of this natural animal model to study pathological mechanisms will, therefore, contribute to a better understanding of its human counterpart. Here, we present a brain-wide histopathological analysis of FEPSO. We discovered that blood–brain barrier (BBB leakage was present not only in all regions of the hippocampus but also in other limbic structures such as the subiculum, amygdale, and piriform lobe. However, in other regions, such as the cerebellum, no leakage was observed. In addition, this brain-region-specific immunoglobulin leakage was associated with the breakdown of endothelial tight junctions. Brain areas affected by BBB dysfunction also revealed immunoglobulin and complement deposition as well as neuronal cell death. These neuropathological findings were supported by magnetic resonance imaging showing signal and volume increase in the amygdala and the piriform lobe. Importantly, we could show that BBB disturbance in LGI1 encephalitis does not depend on T cell infiltrates, which were present brain-wide. This finding points toward another, so far unknown, mechanism of opening the BBB. The limbic predilection sites of immunoglobulin antibody leakage into the brain may explain why most patients with LGI1 antibodies have a limbic phenotype even though LGI1, the target protein, is ubiquitously distributed across the central nervous system.

  9. Selective Limbic Blood-Brain Barrier Breakdown in a Feline Model of Limbic Encephalitis with LGI1 Antibodies.

    Science.gov (United States)

    Tröscher, Anna R; Klang, Andrea; French, Maria; Quemada-Garrido, Lucía; Kneissl, Sibylle Maria; Bien, Christian G; Pákozdy, Ákos; Bauer, Jan

    2017-01-01

    Human leucine-rich glioma-inactivated protein 1 encephalitis (LGI1) is an autoimmune limbic encephalitis in which serum and cerebrospinal fluid contain antibodies targeting LGI1, a protein of the voltage gated potassium channel (VGKC) complex. Recently, we showed that a feline model of limbic encephalitis with LGI1 antibodies, called feline complex partial seizures with orofacial involvement (FEPSO), is highly comparable to human LGI1 encephalitis. In human LGI1 encephalitis, neuropathological investigations are difficult because very little material is available. Taking advantage of this natural animal model to study pathological mechanisms will, therefore, contribute to a better understanding of its human counterpart. Here, we present a brain-wide histopathological analysis of FEPSO. We discovered that blood-brain barrier (BBB) leakage was present not only in all regions of the hippocampus but also in other limbic structures such as the subiculum, amygdale, and piriform lobe. However, in other regions, such as the cerebellum, no leakage was observed. In addition, this brain-region-specific immunoglobulin leakage was associated with the breakdown of endothelial tight junctions. Brain areas affected by BBB dysfunction also revealed immunoglobulin and complement deposition as well as neuronal cell death. These neuropathological findings were supported by magnetic resonance imaging showing signal and volume increase in the amygdala and the piriform lobe. Importantly, we could show that BBB disturbance in LGI1 encephalitis does not depend on T cell infiltrates, which were present brain-wide. This finding points toward another, so far unknown, mechanism of opening the BBB. The limbic predilection sites of immunoglobulin antibody leakage into the brain may explain why most patients with LGI1 antibodies have a limbic phenotype even though LGI1, the target protein, is ubiquitously distributed across the central nervous system.

  10. Optimalization of selected RFID systems Parameters

    Directory of Open Access Journals (Sweden)

    Peter Vestenicky

    2004-01-01

    Full Text Available This paper describes procedure for maximization of RFID transponder read range. This is done by optimalization of magnetics field intensity at transponder place and by optimalization of antenna and transponder coils coupling factor. Results of this paper can be used for RFID with inductive loop, i.e. system working in near electromagnetic field.

  11. Fusion hindrance at deep sub-barrier energies for the 11B+197Au system

    Science.gov (United States)

    Shrivastava, A.; Mahata, K.; Nanal, V.; Pandit, S. K.; Parkar, V. V.; Rout, P. C.; Dokania, N.; Ramachandran, K.; Kumar, A.; Chatterjee, A.; Kailas, S.

    2017-09-01

    Fusion cross sections for the 11B+197Au system have been measured at energies around and deep below the Coulomb barrier, to probe the occurrence of fusion hindrance in case of asymmetric systems. A deviation with respect to the standard coupled channels calculations has been observed at the lowest energy. The results have been compared with an adiabatic model calculation that considers a damping of the coupling strength for a gradual transition from sudden to adiabatic regime at very low energies. The data could be explained without inclusion of the damping factor. This implies that the influence of fusion hindrance is not significant within the measured energy range for this system. The present result is consistent with the observed trend between the degree of fusion hindrance and the charge product that reveals a weaker influence of hindrance on fusion involving lighter projectiles on heavy targets.

  12. Incentives and barriers for wind power expansion and system integration in Denmark

    DEFF Research Database (Denmark)

    Hvelplund, Frede; Ostergaard, Poul Alberg; Meyer, Niels I

    2017-01-01

    In Denmark expansion of on-shore, near-shore and off-shore wind power is planned to increase the wind power share to 50% of electricity consumption by 2020. In this situation a continuation of past policies will not suffice, and a dual-track incentive system that both establishes incentives...... for investing in wind power and integration infrastructure with integration between the electricity, heating and transportation sectors, is required. The current Danish taxation system discourages electricity use and works against this integration. Likewise, the current day-ahead electricity spot market...... is not appropriate for a high-wind future as wind reduces price levels, but integration across sectors can partly assist in increasing demand and prices. The European Emission Trading System does not suffice in providing a level playing field for wind power and thus needs a revision. Another barrier for on...

  13. Selection of Fuel System for Modern Heavy Duty Diesel Engines

    Directory of Open Access Journals (Sweden)

    G. M. Kukharonok

    2004-01-01

    Full Text Available Fuel systems of diesel engines have been analyzed. The paper shows components of the systems, peculiarities of their manufacturing process. Difference in efficiency of the systems, their application and market prospects are considered in the paper. While solving problems to design a power installation the essence of fuel system selection is given on the basis of an internal combustion engine.

  14. Health system and societal barriers for gestational diabetes mellitus (GDM) services - lessons from World Diabetes Foundation supported GDM projects

    DEFF Research Database (Denmark)

    Nielsen, Karoline Kragelund; de Courten, Maximilian; Kapur, Anil

    2012-01-01

    for the offspring. A better understanding of the barriers hindering detection and treatment of GDM is needed. Based on experiences from World Diabetes Foundation (WDF) supported GDM projects this paper seeks to investigate societal and health system barriers to such efforts. Methods Questionnaires were filled out...... by 10 WDF supported GDM project partners implementing projects in eight different LMIC. In addition, interviews were conducted with the project partners. The interviews were analysed using content analysis. Results Barriers to improving maternal health related to GDM nominated by project implementers...

  15. Experimental fusion excitation functions and derived barrier distributions for heavy ion systems involving prolate and oblate target nuclei

    International Nuclear Information System (INIS)

    Bierman, J.D.; Chan, P.; Liang, J.F.; Kelly, M.P.; Sonzogni, A.A.; Vandenbosch, R.

    1996-01-01

    Fusion excitation functions spanning the entire barrier region in 1 MeV energy steps for the two systems 40 Ca + 192 Os, 194 Pt are presented. The results of fission fragment angular distribution measurements for fusion-fission of 40 Ca + 197 Au at several projectile energies within the barrier region are also presented. The fusion data is of high enough precision to allow for extraction of the distribution of fusion barriers from the second differential of the product of E and σ. Basic coupled channels calculations which are in quite good agreement with the data are shown and discussed

  16. Next generation of non-mammalian blood-brain barrier models to study parasitic infections of the central nervous system

    Science.gov (United States)

    Siddiqui, Ruqaiyyah; Edwards-Smallbone, James; Flynn, Robin; Khan, Naveed Ahmed

    2012-01-01

    Transmigration of neuropathogens across the blood-brain barrier is a key step in the development of central nervous system infections, making it a prime target for drug development. The ability of neuropathogens to traverse the blood-brain barrier continues to inspire researchers to understand the specific strategies and molecular mechanisms that allow them to enter the brain. The availability of models of the blood-brain barrier that closely mimic the situation in vivo offers unprecedented opportunities for the development of novel therapeutics. PMID:21921682

  17. Magnetic Materials: Novel Monitors of Long-Term Evolution of Engineered Barrier Systems

    Directory of Open Access Journals (Sweden)

    Simon L. Harley

    2016-12-01

    Full Text Available Most safety cases for the deep geological disposal of radioactive waste are reliant on the swelling of bentonite in the engineered barrier system as it saturates with groundwater. Assurance of safety therefore requires effective monitoring of bentonite saturation. The time- and fluid-dependent corrosion of synthetic magnets embedded in bentonite is demonstrated here to provide a novel and passive means of monitoring saturation. Experiments have been conducted at 70 °C in which neo magnets, AlNiCo magnets, and ferrite magnets have been reacted with saline (NaCl, KCl, CaCl2 solutions and alkaline fluids (NaOH, KOH, Ca(OH2 solutions; pH = 12 in the presence of bentonite. Nd-Fe-B magnets undergo extensive corrosion that results in a dramatic change from ferromagnetic to superparamagnetic behaviour concomitant with bentonite saturation. AlNiCo magnets in saline solutions show corrosion but only limited decreases in their magnetic intensities, and ferrite magnets are essentially unreactive on the experimental timescales, retaining their initial magnetic properties. For all magnets the impact of their corrosion on bentonite swelling is negligible; alteration of bentonite is essentially governed by the applied fluid composition. In principle, synthetic magnet arrays can, with further development, be designed and embedded in bentonite to monitor its fluid saturation without compromising the integrity of the engineered barrier system itself.

  18. Performance Confirmation for the Engineered Barrier System. Report of a Workshop

    International Nuclear Information System (INIS)

    Bennett, David G.

    2004-08-01

    As part of preparations for review of future license applications, the Swedish Nuclear Power Inspectorate (SKI) organised a workshop on the engineered barrier system for the KBS-3 concept, focused on Performance Confirmation (PC). The workshop was held during 12 - 14 May, 2004 at Oskarshamn. The main purpose of the workshop was to identify key issues relating to the demonstration of long-term safety using a system of engineered barriers. The workshop began with introductory presentations on Performance Confirmation, on monitoring, and on long-term experiments in underground research laboratories. Working groups were then convened to discuss these topics and identify questions to put to the Swedish Nuclear Fuel and Waste Management Company (SKB) the following day. On the second day, SKB made several presentations, mainly on long-term experiments conducted at the Aespoe underground research laboratory. These presentations were followed by an informal session during which the questions identified by the working groups on the first day were discussed with SKB and its representatives. This report includes the questions identified by the working groups and a summary of the workshop discussions. Extended abstracts for the introductory presentations are included in an appendix. The conclusions and viewpoints presented in this report are those of one or several workshop participants. They do not necessarily coincide with those of SKI

  19. Integrating observational and modelling systems for the management of the Great Barrier Reef

    Science.gov (United States)

    Baird, M. E.; Jones, E. M.; Margvelashvili, N.; Mongin, M.; Rizwi, F.; Robson, B.; Schroeder, T.; Skerratt, J.; Steven, A. D.; Wild-Allen, K.

    2016-02-01

    Observational and modelling systems provide two sources of knowledge that must be combined to provide a more complete view than either observations or models alone can provide. Here we describe the eReefs coupled hydrodynamic, sediment and biogeochemical model that has been developed for the Great Barrier Reef; and the multiple observations that are used to constrain the model. Two contrasting examples of model - observational integration are highlighted. First we explore the carbon chemistry of the waters above the reef, for which observations are accurate, but expensive and therefore sparse, while model behaviour is highly skilful. For carbon chemistry, observations are used to constrain model parameterisation and quantify model error, with the model output itself providing the most useable knowledge for management purposes. In contrast, ocean colour provides inaccurate, but cheap and spatially and temporally extensive observations. Thus observations are best combined with the model in a data assimilating framework, where a custom-designed optical model has been developed for the purposes of incorporating ocean colour observations. The future management of Great Barrier Reef water quality will be based on an integration of observing and modelling systems, providing the most robust information available.

  20. Socio-cultural barriers to the development of a sustainable energy system - the case of hydrogen

    Energy Technology Data Exchange (ETDEWEB)

    Kjerulf Petersen, L.; Holst Andersen, A.

    2009-02-15

    Any transition to a more sustainable energy system, radically reducing greenhouse gas emissions, is bound to run in to a host of different barriers - technological and economic, but also socio-cultural. This will also be the case for any large-scale application of hydrogen as energy carrier, especially if the system is going to be based on renewable energy sources. The aim of these research notes is to review and discuss major socio-cultural barriers to new forms of energy supply in general and to hydrogen specifically. Reaching sufficient reductions in greenhouse gas emissions may require more than large-scale dissemination of renewable energy sources. Also reductions or moderations in energy demand may be necessary. Hence, a central point in the research note is to consider not only socio-cultural obstacles for changing technologies in energy production, distribution and consumption but also obstacles for changing the scale of energy consumption, i.e. moderating the growth in how much energy is consumed or even reducing consumption volumes. (au)

  1. Comparison and selection of off-grid PV systems

    Science.gov (United States)

    Izmailov, Andrey Yu.; Lobachevsky, Yakov P.; Shepovalova, Olga V.

    2018-05-01

    This work deals with comparison, evaluation and selection of PV systems of the same type based on their technical parameters either indicated in their technical specifications or calculated ones. Stand-alone and grid backed up photoelectric systems have been considered. General requirements for photoelectric system selection and evaluation have been presented that ensure system operability and required efficiency in operation conditions. Generic principles and definition of photoelectric systems characteristics have been considered. The described method is mainly targeted at PV engineering personnel and private customers purchasing PV systems. It can be also applied in the course of project contests, tenders, etc.

  2. Low resolution spectroscopy of selected Algol systems

    Science.gov (United States)

    Devarapalli, Shanti Priya; Jagirdar, Rukmini; Parthasarathy, M.; Sahu, D. K.; Mohan, Vijay; Bhatt, B. C.; Thomas, Vineet S.

    2018-04-01

    The analysis of spectroscopic data for 30 Algol-type binaries is presented. All these systems are short period Algols having primaries with spectral types B and A. Dominant spectral lines were identified for the spectra collected and their equivalent widths were calculated. All the spectra were examined to understand presence of mass transfer, a disk or circumstellar matter and chromospheric emission. We also present first spectroscopic and period study for few Algols and conclude that high resolution spectra within and outside the primary minimum are needed for better understanding of these Algol type close binaries.

  3. Application of the "Behind the Barriers" resilience conceptual model to a flooded rail transport system

    Science.gov (United States)

    Gonzva, Michael; Barroca, Bruno

    2017-04-01

    The vulnerability of guided transport systems facing natural hazards is a burning issue for the urban risks management. Experience feedbacks on guided transport systems show they are particularly vulnerable to natural risks, especially flood risks. Besides, the resilience concept is used as a systemic approach for making an accurate analysis of the effect of these natural risks on rail guided transport systems. In this context, several conceptual models of resilience are elaborated for presenting the various possible resilience strategies applied to urban technical systems. One of this resilience conceptual model is the so-called "Behind The Barriers" model based on the identification of four complementary types of resilience: (i) cognitive resilience, linked to knowledge of the risk and the potential failures; (ii) functional resilience, representing the capacity of a system to protect itself from damage while continuing to provide services; (iii) correlative resilience, that characterises the relationship between service demand and the capacity of the system to respond; (iv) organisational resilience, expressing the capacity to mobilise an area much wider than the one affected. In addition to the work already published during the 7th Resilience Engineering Symposium, the purpose of this paper is to offer an application of a resilience conceptual model, the "Behind the Barriers" model, relating to a specific urban technical system, the public guided transport system, and facing a particular risk, a flood hazard. To do that, the paper is focused on a past incident on a French Intercity railway line as a studied case. Indeed, on June 18th and 19th 2013, the rise of the level of the "Gave de Pau" river, located in the municipality of Coarraze, caused many disorders on the intercity line serving the cities of Tarbes, Pau and Lourdes . Among the disorders caused by the flooding, about 100 meters of railway embankments were collapsed. With a constraint to reopen the

  4. The Australian REEFREP System: A Coastal Vessel Traffic Information Service and Ship Reporting System for the Torres Strait Region and the Inner Route of the Great Barrier Reef

    Science.gov (United States)

    MacDonald, John C.

    The new Australian ship reporting system, identifier , will be the core component of a Vessel Traffic Information Service (VTIS) covering the Torres Strait region and the Great Barrier Reef (GBR). It is the first such system to be considered by the International Maritime Organization (IMO) under the terms of the new SOLAS 74 regulation v/8-1, which entered into force on 1 January 1996 and allows for ship reporting systems adopted by the Organization to be made mandatory for all, or certain categories of vessels.The REEFREP system, planned for implementation on 1 January 1997, extends for some 900 n.m. or about 1500 km along the Queensland coastline. It will be a VHF radio-based system with radars covering three selected focal points in the Torres Strait, off Cairns and in the southern approaches to the inner route. The system will provide a capability for a single Ship Reporting Centre to interact with shipping, enabling the provision of improved information on the presence, movements and patterns of shipping in the area and the ability to respond more quickly to an incident or pollution should this occur.An interesting feature and a major factor in the system design is the remoteness of most equipment sites and the limited infrastructure available to support communications and data transmission requiring the application of advanced technology and video transmission, solar power generation and software engineering skills of a high order.

  5. Quantifying system safety: A comparison of the SBOAT & Safety Barrier Manager tools

    OpenAIRE

    Hansen, Zaza Nadja Lee; Duijm, Nijs Jan; Markert, Frank; Herbert, Luke Thomas

    2015-01-01

    This paper presents two software tools for analyzing safety risks, SBOAT (Stochastic BPMN Optimisation and Analysis Tool) and SBM (SafetyBarrierManagerr). SBOAT employs principles from stochastic model checking to allow for the quantitative verification of workflows. SBM supports the creation of valid safety-barrier diagrams and allows the quantitative analysis of the probability of all possible end states of the barrier diagram, i.e. the outcomes if one or several of the barriers fail to per...

  6. Associations among Selected Motor Skills and Health-Related Fitness: Indirect Evidence for Seefeldt's Proficiency Barrier in Young Adults?

    Science.gov (United States)

    Stodden, David F.; True, Larissa K.; Langendorfer, Stephen J.; Gao, Zan

    2013-01-01

    Purpose: This exploratory study examined the notion of Seefeldt's (1980) hypothesized motor skill "proficiency barrier" related to composite levels of health-related physical fitness (HRF) in young adults. Method: A motor skill competence (MSC) index composed of maximum throwing and kicking speed and jumping distance in 187 young adults…

  7. Expertise, Time, Money, Mentoring, and Reward: Systemic Barriers That Limit Education Researcher Productivity-Proceedings From the AAMC GEA Workshop.

    Science.gov (United States)

    Yarris, Lalena M; Juve, Amy Miller; Artino, Anthony R; Sullivan, Gail M; Rougas, Steven; Joyce, Barbara; Eva, Kevin

    2014-09-01

    To further evolve in an evidence-based fashion, medical education needs to develop and evaluate new practices for teaching, learning, and assessment. However, educators face barriers in designing, conducting, and publishing education research. To explore the barriers medical educators face in formulating, conducting, and publishing high-quality medical education research, and to identify strategies for overcoming them. A consensus workshop was held November 5, 2013, at the Association of American Medical Colleges annual meeting. A working group of education research experts and educators completed a preconference literature review focusing on barriers to education research. During the workshop, consensus-based and small group techniques were used to refine the broad themes into content categories. Attendees then ranked the most important barriers and strategies for overcoming them with the highest potential impact. Barriers participants faced in conducting quality education research included lack of (1) expertise, (2) time, (3) funding, (4) mentorship, and (5) reward. The strategy considered most effective in overcoming these barriers involved building communities of education researchers for collaboration and networking, and advocating for education researchers' interests. Other suggestions included trying to secure increased funding opportunities, developing mentoring programs, and encouraging mechanisms to ensure protected time. Barriers to education research productivity clearly exist. Many appear to result from feelings of isolation that may be overcome with systemic efforts to develop and enable communities of practice across institutions. Finally, the theme of "reward" is novel and complex and may have implications for education research productivity.

  8. Economy system and operation of a selected retail chain

    OpenAIRE

    KALUSOVÁ, Monika

    2011-01-01

    The goal of the thesis Economy system and operation of a selected retail chain is to explore and analyze the sphere in which the retailer chain operates, and evaluate their financial situation. At the same time, the selected retail chain will compare with the selected sectoral competition. The first part of thesis covers the theoretical information about issues, in particular the definition of basic terms of trade and retail. The second part of thesis includes application theoretical knowledg...

  9. Optimistic Selection Rule Better Than Majority Voting System

    Science.gov (United States)

    Sugiyama, Takuya; Obata, Takuya; Hoki, Kunihito; Ito, Takeshi

    A recently proposed ensemble approach to game-tree search has attracted a great deal of attention. The ensemble system consists of M computer players, where each player uses a different series of pseudo-random numbers. A combination of multiple players under the majority voting system would improve the performance of a Shogi-playing computer. We present a new strategy of move selection based on the search values of a number of players. The move decision is made by selecting one player from all M players. Each move is selected by referring to the evaluation value of the tree search of each player. The performance and mechanism of the strategy are examined. We show that the optimistic selection rule, which selects the player that yields the highest evaluation value, outperforms the majority voting system. By grouping 16 or more computer players straightforwardly, the winning rates of the strongest Shogi programs increase from 50 to 60% or even higher.

  10. Waste system optimization - can diameter selection

    International Nuclear Information System (INIS)

    Ashline, R.C.

    1983-08-01

    The purpose of the waste system optimization study is to define in terms of cost incentives the preferred waste package for HLW which has been converted to glass at a commercial reprocessing plant. The Waste Management Economic Model (WMEM) was employed to analyze the effect of varying important design parameters on the overall net present cost of waste handling. The parameters found to have the greatest effect on the calculated overall net present cost were can diameter, repository type (salt, basalt/bentonite, or welded tuff), allowable areal heat loading, and the repository availability date. The overall net present of a waste handling option is calculated over a 20-year operating period. It includes the total capital and operating costs associated with high-level and intermediate-level liquid waste storage, liquid waste solidification, hulls storage and compaction, and general process trash handling. It also includes the cask leasing and transportation costs associated with each waste type and the waste repository disposal costs. The waste repository disposal costs used in WMEM for this analysis were obtained from Battelle Pacific Northwest Laboratories and thir RECON model. 2 figures, 2 tables

  11. ERP systems selection in multinational enterprises: a practical guide

    Directory of Open Access Journals (Sweden)

    Moutaz Haddara

    2018-01-01

    Full Text Available The Enterprise Resource Planning (ERP system selection is an early phase in the ERP adoption process. When organizations evaluate an ERP, they commonly develop their own selection criteria that usually involve various system and vendor related factors. While the selection process is critical, however, there is an apparent research gap in literature. The ERP selection effort also focuses on the system’s fit with the organizational requirements and needs. Thus, the selection phase is critical, because if an organization chooses an unfit ERP, the whole project could be predestined to fail. This research provides an overview of an ERP selection process at an overseas branch office of a multinational company. The process employed a simple multi-attribute rating technique (SMART for evaluation. In addition, this research presents how cross-border data protection laws between the parent company and its branch have influenced the selection process. As the ERP system has been implemented successfully, the method and the selection factors have been proven adequate for the selection process.

  12. Strategies to overcome barriers for cleaner generation technologies in small developing power systems: Sri Lanka case study

    International Nuclear Information System (INIS)

    Wijayatunga, Priyantha D.C.; Siriwardena, Kanchana; Fernando, W.J.L.S.; Shrestha, Ram M.; Attalage, Rahula A.

    2006-01-01

    The penetration of cleaner and energy efficient technologies in small power systems such as the one in Sri Lanka has encountered many problems. This has caused major concerns among the policy makers, mainly in the context of the growing need to reduce harmful emissions in the electricity supply industry from the point of view of both local environmental pollution as well as the global warming concerns. This paper presents the outcome of a study involved in identifying and ranking the barriers to the promotion of cleaner and energy efficient technologies and strategies to overcome these barriers in Sri Lanka. Barriers for renewable energy based systems such as wind and wood fuel fired plants (dendro thermal power) and cleaner technologies such as liquefied natural gas (LNG) fired combined cycle and IGCC (coal) were identified based on a survey. A direct assessment multi-criteria decision making method called Analytic Hierarchy Process (AHP) was used to rank the barriers. The most effective strategies are proposed to address the three major barriers for each of these technologies based on extensive discussions with all the stakeholders in the electricity industry. It was found that lack of financing instruments, high initial cost and lack of assurance of resource supply or availability are the main barriers for renewable technologies. As for cleaner fuel and technology options associated with conventional generation systems, the lack of a clear government policy, uncertainty of fuel supplies and their prices and the reliability of the technologies themselves are the major barriers. Strategies are identified to overcome the above barriers. Establishment of a proper feed in tariff, geographical diversification of installations and capacity building in commercial banks are suggested for wind power. Investment incentives, streamlining of wood production and research on site identification are proposed for wood fuel fired plants. Also the study suggests delayed

  13. ECMS--Educational Contest Management System for Selecting Elite Students

    Science.gov (United States)

    Schneider, Thorsten

    2004-01-01

    Selecting elite students out of a huge collective is a difficult task. The main problem is to provide automated processes to reduce human work. ECMS (Educational Contest Management System) is an online tool approach to help--fully or partly automated--with the task of selecting such elite students out of a mass of candidates. International tests…

  14. Anthrax lethal toxin disrupts intestinal barrier function and causes systemic infections with enteric bacteria.

    Directory of Open Access Journals (Sweden)

    Chen Sun

    Full Text Available A variety of intestinal pathogens have virulence factors that target mitogen activated protein kinase (MAPK signaling pathways, including Bacillus anthracis. Anthrax lethal toxin (LT has specific proteolytic activity against the upstream regulators of MAPKs, the MAPK kinases (MKKs. Using a murine model of intoxication, we show that LT causes the dose-dependent disruption of intestinal epithelial integrity, characterized by mucosal erosion, ulceration, and bleeding. This pathology correlates with an LT-dependent blockade of intestinal crypt cell proliferation, accompanied by marked apoptosis in the villus tips. C57BL/6J mice treated with intravenous LT nearly uniformly develop systemic infections with commensal enteric organisms within 72 hours of administration. LT-dependent intestinal pathology depends upon its proteolytic activity and is partially attenuated by co-administration of broad spectrum antibiotics, indicating that it is both a cause and an effect of infection. These findings indicate that targeting of MAPK signaling pathways by anthrax LT compromises the structural integrity of the mucosal layer, serving to undermine the effectiveness of the intestinal barrier. Combined with the well-described immunosuppressive effects of LT, this disruption of the intestinal barrier provides a potential mechanism for host invasion via the enteric route, a common portal of entry during the natural infection cycle of Bacillus anthracis.

  15. Progress report for project modeling Arctic barrier island-lagoon system response to projected Arctic warming

    Science.gov (United States)

    Erikson, Li H.; Gibbs, Ann E.; Richmond, Bruce M.; Storlazzi, Curt; B.M. Jones,

    2012-01-01

    Changes in Arctic coastal ecosystems in response to global warming may be some of the most severe on the planet. A better understanding and analysis of the rates at which these changes are expected to occur over the coming decades is crucial in order to delineate high-priority areas that are likely to be affected by climate changes. In this study we investigate the likelihood of changes to habitat-supporting barrier island – lagoon systems in response to projected changes in atmospheric and oceanographic forcing associated with Arctic warming. To better understand the relative importance of processes responsible for the current and future coastal landscape, key parameters related to increasing arctic temperatures are investigated and used to establish boundary conditions for models that simulate barrier island migration and inundation of deltaic deposits and low-lying tundra. The modeling effort investigates the dominance and relative importance of physical processes shaping the modern Arctic coastline as well as decadal responses due to projected conditions out to the year 2100.

  16. Interaction between blood-brain barrier and glymphatic system in solute clearance.

    Science.gov (United States)

    Verheggen, I C M; Van Boxtel, M P J; Verhey, F R J; Jansen, J F A; Backes, W H

    2018-03-30

    Neurovascular pathology concurs with protein accumulation, as the brain vasculature is important for waste clearance. Interstitial solutes, such as amyloid-β, were previously thought to be primarily cleared from the brain by blood-brain barrier transport. Recently, the glymphatic system was discovered, in which cerebrospinal fluid is exchanged with interstitial fluid, facilitated by the aquaporin-4 water channels on the astroglial endfeet. Glymphatic flow can clear solutes from the interstitial space. Blood-brain barrier transport and glymphatic clearance likely serve complementary roles with partially overlapping mechanisms providing a well-conditioned neuronal environment. Disruption of these mechanisms can lead to protein accumulation and may initiate neurodegenerative disorders, for instance amyloid-β accumulation and Alzheimer's disease. Although both mechanisms seem to have a similar purpose, their interaction has not been clearly discussed previously. This review focusses on this interaction in healthy and pathological conditions. Future health initiatives improving waste clearance might delay or even prevent onset of neurodegenerative disorders. Defining glymphatic flow kinetics using imaging may become an alternative way to identify those at risk of Alzheimer's disease. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

  17. Polycyclic selection system for the tropical rainforests of northern Australia

    Science.gov (United States)

    Glen T. Dale; Grahame B. Applegate

    1992-01-01

    The polycyclic selection logging system developed and practiced for many years in the tropical rainforests of north Queensland has been successful in integrating timber production with the protection of conservation values. The system has been used by the Queensland Forest Service to manage north Queensland rainforests. The Queensland system has considerable potential...

  18. Sequence Selection and Performance in DS/CDMA Systems

    Directory of Open Access Journals (Sweden)

    Jefferson Santos Ambrosio

    2016-03-01

    Full Text Available In this work key concepts on coding division multiple access (CDMA communication systems have been discussed. The sequence selection impact on the performance and capacity of direct sequence CDMA (DS/CDMA systems under AWGN and increasing system loading, as well as under multiple antennas channels was investigated.

  19. Space Station Freedom regenerative water recovery system configuration selection

    Science.gov (United States)

    Reysa, R.; Edwards, J.

    1991-01-01

    The Space Station Freedom (SSF) must recover water from various waste water sources to reduce 90 day water resupply demands for a four/eight person crew. The water recovery system options considered are summarized together with system configuration merits and demerits, resource advantages and disadvantages, and water quality considerations used to select the SSF water recovery system.

  20. Matching People and Jobs: Value Systems and Employee Selection.

    Science.gov (United States)

    Heflich, Debra L.

    1981-01-01

    Offers strategies, based on six value systems, to reduce employee turnover. Maintains that understanding the value systems of people as they relate to jobs is the key to improving the selection process, and that employees should be chosen in accordance with how well their value systems match their work and work environments.

  1. Effective selection of transgenic papaya plants with the PMI/Man selection system.

    Science.gov (United States)

    Zhu, Yun J; Agbayani, Ricelle; McCafferty, Heather; Albert, Henrik H; Moore, Paul H

    2005-09-01

    The selectable marker gene phospho-mannose isomerase (pmi), which encodes the enzyme phospho-mannose isomerase (PMI) to enable selection of transformed cell lines on media containing mannose (Man), was evaluated for genetic transformation of papaya (Carica papaya L.). We found that papaya embryogenic calli have little or no PMI activity and cannot utilize Man as a carbon source; however, when calli were transformed with a pmi gene, the PMI activity was greatly increased and they could utilize Man as efficiently as sucrose. Plants regenerated from selected callus lines also exhibited PMI activity but at a lower specific activity level. Our transformation efficiency with Man selection was higher than that reported using antibiotic selection or with a visual marker. For papaya, the PMI/Man selection system for producing transgenic plants is a highly efficient addition to previously published methods for selection and may facilitate the stacking of multiple transgenes of interest. Additionally, since the PMI/Man selection system does not involve antibiotic or herbicide resistance genes, its use might reduce environmental concerns about the potential flow of those genes into related plant populations.

  2. Enershield : energy saving air barriers

    Energy Technology Data Exchange (ETDEWEB)

    Hallihan, D. [Enershield Industries Ltd., Edmonton, AB (Canada)

    2008-07-01

    Enershield Industries is a leader in air barrier technology and provides solution for the Canadian climate. This presentation described the advantages of air barriers and the impact of rising energy costs. An air barrier is used to separate areas of differing environments and makes existing building systems more efficient. This presentation discussed how an air barrier works. It also identified how Enershield Industries calculates energy savings. It described air barrier applications and those who use barrier technology. These include the commercial and industrial sector as well as the personnel and retail sector. Barrier technology can be used for cold storage; vehicle and equipment washes; food processing; and environmental separation. Features and benefits such as the ability to create seal, acoustic insulation, and long term durability were also discussed. Last, the presentation addressed model selection and design criteria issues. Design criteria that were presented included a discussion of acoustic installation, articulating nozzles, scroll cased fans, and structural frame. Other design criteria presented were galvanized frames, telescopic sliders, and off the shelf parts. It was concluded that the ability to reduce energy consumption and enhance employee/client comfort is beneficial to the employer as well as to the employee. figs.

  3. Zebrafish as a visual and dynamic model to study the transport of nanosized drug delivery systems across the biological barriers.

    Science.gov (United States)

    Li, Ye; Miao, Xiaoqing; Chen, Tongkai; Yi, Xiang; Wang, Ruibing; Zhao, Haitao; Lee, Simon Ming-Yuen; Wang, Xueqing; Zheng, Ying

    2017-08-01

    With the wide application of nanotechnology to drug delivery systems, a simple, dynamic and visual in vivo model for high-throughput screening of novel formulations with fluorescence markers across biological barriers is desperately needed. In vitro cell culture models have been widely used, although they are far from a complimentary in vivo system. Mammalian animal models are common predictive models to study transport, but they are costly and time consuming. Zebrafish (Danio rerio), a small vertebrate model, have the potential to be developed as an "intermediate" model for quick evaluations. Based on our previously established coumarin 6 nanocrystals (C6-NCs), which have two different sizes, the present study investigates the transportation of C6-NCs across four biological barriers, including the chorion, blood brain barrier (BBB), blood retinal barrier (BRB) and gastrointestinal (GI) barrier, using zebrafish embryos and larvae as in vivo models. The biodistribution and elimination of C6 from different organs were quantified in adult zebrafish. The results showed that compared to 200nm C6-NCs, 70nm C6-NCs showed better permeability across these biological barriers. A FRET study suggested that intact C6-NCs together with the free dissolved form of C6 were absorbed into the larval zebrafish. More C6 was accumulated in different organs after incubation with small sized NCs via lipid raft-mediated endocytosis in adult zebrafish, which is consistent with the findings from in vitro cell monolayers and the zebrafish larvae model. C6-NCs could be gradually eliminated in each organ over time. This study demonstrated the successful application of zebrafish as a simple and dynamic model to simultaneously assess the transport of nanosized drug delivery systems across several biological barriers and biodistribution in different organs, especially in the brain, which could be used for central nervous system (CNS) drug and delivery system screening. Copyright © 2017 Elsevier B

  4. Isotopic effects in sub-barrier fusion of Si + Si systems

    Science.gov (United States)

    Colucci, G.; Montagnoli, G.; Stefanini, A. M.; Esbensen, H.; Bourgin, D.; Čolović, P.; Corradi, L.; Faggian, M.; Fioretto, E.; Galtarossa, F.; Goasduff, A.; Grebosz, J.; Haas, F.; Mazzocco, M.; Scarlassara, F.; Stefanini, C.; Strano, E.; Szilner, S.; Urbani, M.; Zhang, G. L.

    2018-04-01

    Background: Recent measurements of fusion cross sections for the 28Si+28Si system revealed a rather unsystematic behavior; i.e., they drop faster near the barrier than at lower energies. This was tentatively attributed to the large oblate deformation of 28Si because coupled-channels (CC) calculations largely underestimate the 28Si+28Si cross sections at low energies, unless a weak imaginary potential is applied, probably simulating the deformation. 30Si has no permanent deformation and its low-energy excitations are of a vibrational nature. Previous measurements of this system reached only 4 mb, which is not sufficient to obtain information on effects that should show up at lower energies. Purpose: The aim of the present experiment was twofold: (i) to clarify the underlying fusion dynamics by measuring the symmetric case 30Si+30Si in an energy range from around the Coulomb barrier to deep sub-barrier energies, and (ii) to compare the results with the behavior of 28Si+28Si involving two deformed nuclei. Methods: 30Si beams from the XTU tandem accelerator of the Laboratori Nazionali di Legnaro of the Istituto Nazionale di Fisica Nucleare were used, bombarding thin metallic 30Si targets (50 μ g /cm2) enriched to 99.64 % in mass 30. An electrostatic beam deflector allowed the detection of fusion evaporation residues (ERs) at very forward angles, and angular distributions of ERs were measured. Results: The excitation function of 30Si+30Si was measured down to the level of a few microbarns. It has a regular shape, at variance with the unusual trend of 28Si+28Si . The extracted logarithmic derivative does not reach the LCS limit at low energies, so that no maximum of the S factor shows up. CC calculations were performed including the low-lying 2+ and 3- excitations. Conclusions: Using a Woods-Saxon potential the experimental cross sections at low energies are overpredicted, and this is a clear sign of hindrance, while the calculations performed with a M3Y + repulsion

  5. Near barrier fusion, breakup and scattering for the 9Be + 144Sm system

    International Nuclear Information System (INIS)

    Paes, B.; Lubian, J.; Gomes, P.R.S.; Padron, I.; Canto, L.F.

    2009-01-01

    Full text: The investigation of the break-up process of weakly bound nuclei and its influence on the fusion cross section and elastic scattering has been investigated in the last years by different approaches. One of these approaches is the comparison of data of complete fusion (CF) cross sections with predictions from CC calculations which do not include the break-up channel. Different phenomena leading to opposite effects on the fusion cross section may be identified: static effects arising from the longer tail of the nuclear potential and the large size of the weakly bound nuclei, leading to a smaller Coulomb barrier, and dynamical effects, either like the strong coupling between the elastic and continuum states, that takes flux that otherwise would go to fusion or like the coupling of soft resonance states. Very recently a method has been developed by us to disentangle these effects. Another approach to perform this study is the investigation of the presence or absence of the threshold anomaly or the break-up threshold anomaly in the elastic scattering at near barrier energies. The attractive or repulsive characters of the polarization potentials associated with the different reaction processes, may lead to enhancement or suppression of the fusion cross section. In this contribution we analyze, by different approaches, a large set of data for the 9 Be + 144 Sm system, including CF and incomplete fusion, elastic and inelastic scattering. We use a reliable double folding potential in CC calculations which either do not take into account the break-up channel or consider resonances of the 9 Be projectile; we also perform simultaneous fits of elastic and CF cross sections; we derive the break-up cross sections and investigate the energy dependence of the real and imaginary optical potentials corresponding to the fusion and direct processes, separately; and we derive the break-up polarization potential for this system. Then, we show the agreement between these

  6. Selective Attention in Multi-Chip Address-Event Systems

    Directory of Open Access Journals (Sweden)

    Giacomo Indiveri

    2009-06-01

    Full Text Available Selective attention is the strategy used by biological systems to cope with the inherent limits in their available computational resources, in order to efficiently process sensory information. The same strategy can be used in artificial systems that have to process vast amounts of sensory data with limited resources. In this paper we present a neuromorphic VLSI device, the “Selective Attention Chip” (SAC, which can be used to implement these models in multi-chip address-event systems. We also describe a real-time sensory-motor system, which integrates the SAC with a dynamic vision sensor and a robotic actuator. We present experimental results from each component in the system, and demonstrate how the complete system implements a real-time stimulus-driven selective attention model.

  7. Selective attention in multi-chip address-event systems.

    Science.gov (United States)

    Bartolozzi, Chiara; Indiveri, Giacomo

    2009-01-01

    Selective attention is the strategy used by biological systems to cope with the inherent limits in their available computational resources, in order to efficiently process sensory information. The same strategy can be used in artificial systems that have to process vast amounts of sensory data with limited resources. In this paper we present a neuromorphic VLSI device, the "Selective Attention Chip" (SAC), which can be used to implement these models in multi-chip address-event systems. We also describe a real-time sensory-motor system, which integrates the SAC with a dynamic vision sensor and a robotic actuator. We present experimental results from each component in the system, and demonstrate how the complete system implements a real-time stimulus-driven selective attention model.

  8. Managing Selection for Electronic Resources: Kent State University Develops a New System to Automate Selection

    Science.gov (United States)

    Downey, Kay

    2012-01-01

    Kent State University has developed a centralized system that manages the communication and work related to the review and selection of commercially available electronic resources. It is an automated system that tracks the review process, provides selectors with price and trial information, and compiles reviewers' feedback about the resource. It…

  9. Smart parking barrier

    KAUST Repository

    Alharbi, Abdulrazaq M.

    2016-05-06

    Various methods and systems are provided for smart parking barriers. In one example, among others, a smart parking barrier system includes a movable parking barrier located at one end of a parking space, a barrier drive configured to control positioning of the movable parking barrier, and a parking controller configured to initiate movement of the parking barrier, via the barrier drive. The movable parking barrier can be positioned between a first position that restricts access to the parking space and a second position that allows access to the parking space. The parking controller can initiate movement of the movable parking barrier in response to a positive identification of an individual allowed to use the parking space. The parking controller can identify the individual through, e.g., a RFID tag, a mobile device (e.g., a remote control, smartphone, tablet, etc.), an access card, biometric information, or other appropriate identifier.

  10. Protection of blood retinal barrier and systemic vasculature by insulin-like growth factor binding protein-3.

    Directory of Open Access Journals (Sweden)

    Yagna P R Jarajapu

    Full Text Available Previously, we showed that insulin growth factor (IGF-1 binding protein-3 (IGFBP-3, independent of IGF-1, reduces pathological angiogenesis in a mouse model of the oxygen-induced retinopathy (OIR. The current study evaluates novel endothelium-dependent functions of IGFBP-3 including blood retinal barrier (BRB integrity and vasorelaxation. To evaluate vascular barrier function, either plasmid expressing IGFBP-3 under the regulation of an endothelial-specific promoter or a control plasmid was injected into the vitreous humor of mouse pups (P1 and compared to the non-injected eyes of the same pups undergoing standard OIR protocol. Prior to sacrifice, the mice were given an injection of horseradish peroxidase (HRP. IGFBP-3 plasmid-injected eyes displayed near-normal vessel morphology and enhanced vascular barrier function. Further, in vitro IGFBP-3 protects retinal endothelial cells from VEGF-induced loss of junctional integrity by antagonizing the dissociation of the junctional complexes. To assess the vasodilatory effects of IGFBP-3, rat posterior cerebral arteries were examined in vitro. Intraluminal IGFBP-3 decreased both pressure- and serotonin-induced constrictions by stimulating nitric oxide (NO release that were blocked by L-NAME or scavenger receptor-B1 neutralizing antibody (SRB1-Ab. Both wild-type and IGF-1-nonbinding mutant IGFBP-3 (IGFBP-3NB stimulated eNOS activity/NO release to a similar extent in human microvascular endothelial cells (HMVECs. NO release was neither associated with an increase in intracellular calcium nor decreased by Ca(2+/calmodulin-dependent protein kinase II (CamKII blockade; however, dephosphorylation of eNOS-Thr(495 was observed. Phosphatidylinositol 3-kinase (PI3K activity and Akt-Ser(473 phosphorylation were both increased by IGFBP-3 and selectively blocked by the SRB1-Ab or PI3K blocker LY294002. In conclusion, IGFBP-3 mediates protective effects on BRB integrity and mediates robust NO release to stimulate

  11. Conservation on international boundaries: the impact of security barriers on selected terrestrial mammals in four protected areas in Arizona, USA.

    Directory of Open Access Journals (Sweden)

    Jamie W McCallum

    Full Text Available Several thousand terrestrial protected areas (PAs lie on international boundaries. Because international boundaries can be focal points for trade, illegal activity and development, such PAs can be vulnerable to a range of anthropogenic threats. There is an increasing trend towards the erection of international boundary infrastructure (including fences, barriers and ditches in many parts of the world, which may reduce the risk of these anthropogenic threats to some PAs. However this may restrict home range and access to resources for some native species. We sought to understand the impacts of these two different types of threat by using camera traps to measure the activity level of humans, native and invasive mammals in four US PAs on the Mexican international boundary. Comparisons were made between treatment areas with barriers and those without. Results showed that puma and coati were more likely to appear in treatment areas without barriers, whereas humans were not observed more frequently in one treatment area over another. The suggestion is that the intermittent fencing present in this part of the world does affect some native species, but does not necessarily restrict the movement of humans (including illegal migrants, who may negatively impact native species.

  12. Optimal Parameter Selection of Power System Stabilizer using Genetic Algorithm

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Hyeng Hwan; Chung, Dong Il; Chung, Mun Kyu [Dong-AUniversity (Korea); Wang, Yong Peel [Canterbury Univeristy (New Zealand)

    1999-06-01

    In this paper, it is suggested that the selection method of optimal parameter of power system stabilizer (PSS) with robustness in low frequency oscillation for power system using real variable elitism genetic algorithm (RVEGA). The optimal parameters were selected in the case of power system stabilizer with one lead compensator, and two lead compensator. Also, the frequency responses characteristics of PSS, the system eigenvalues criterion and the dynamic characteristics were considered in the normal load and the heavy load, which proved usefulness of RVEGA compare with Yu's compensator design theory. (author). 20 refs., 15 figs., 8 tabs.

  13. Goal Selection for Embedded Systems with Oversubscribed Resources

    Science.gov (United States)

    Rabideau, Gregg; Chien, Steve; McLaren, David

    2010-01-01

    We describe an efficient, online goal selection algorithm and its use for selecting goals at runtime. Our focus is on the re-planning that must be performed in a timely manner on the embedded system where computational resources are limited. In particular, our algorithm generates near optimal solutions to problems with fully specified goal requests that oversubscribe available resources but have no temporal flexibility. By using a fast, incremental algorithm, goal selection can be postponed in a "just-in-time" fashion allowing requests to be changed or added at the last minute. This enables shorter response cycles and greater autonomy for the system under control.

  14. Work flow management systems. Selection of Platforms and tools

    International Nuclear Information System (INIS)

    Munoz Garcia, M.

    1997-01-01

    This paper addresses a formal procedure for selecting the Platform and tools necessary to implement a Work Flow system in a company's organisation. The proposed method is based on a preliminary study to ascertain the company's requirements; in other words, the tool is selected on the basis of the environment in which it is to be used, thus making it essential to know the frequency of use, the types of tasks to be executed, the complexity of work flow, etc. Once the preliminary study has been performed, the formal selection method does no differ greatly from that for selecting any other tool. The objective is to establish a series of weighted parameters so that each candidate configuration can be assessed and one finally selected. Lastly, the paper discusses some practical considerations which became evident during the selection of a work flow management tool for our own company. (Author)

  15. Study of an edge transport barrier by Langmuir probes in the compact helical system

    Energy Technology Data Exchange (ETDEWEB)

    Takeuchi, M [Department of Energy Engineering and Science, Nagoya University, Nagoya 464-8603 (Japan); Toi, K [National Institute of Fusion Science, Toki 509-5292 (Japan); Nagaoka, K [National Institute of Fusion Science, Toki 509-5292 (Japan); Suzuki, C [National Institute of Fusion Science, Toki 509-5292 (Japan); Minami, T [National Institute of Fusion Science, Toki 509-5292 (Japan); Akiyama, T [National Institute of Fusion Science, Toki 509-5292 (Japan); Isobe, M [National Institute of Fusion Science, Toki 509-5292 (Japan); Yoshimura, Y [National Institute of Fusion Science, Toki 509-5292 (Japan); Nishimura, S [National Institute of Fusion Science, Toki 509-5292 (Japan); Shimizu, A [National Institute of Fusion Science, Toki 509-5292 (Japan); Takahashi, C [National Institute of Fusion Science, Toki 509-5292 (Japan); Matsuoka, K [National Institute of Fusion Science, Toki 509-5292 (Japan); Okamura, S [National Institute of Fusion Science, Toki 509-5292 (Japan)

    2006-05-15

    The edge transport barrier (ETB) produced by the L-H transition was measured by a triple Langmuir probe (LP) at two toroidal sections of the compact helical system (CHS), of which diagnostic method has good time and spatial resolutions. The radial profiles of electron density (n{sub e}), electron temperature (T{sub e}) and space potential (V{sub s}) in the ETB region have different shapes at two different toroidal sections. These profiles are deformed inside the ETB region at one location and are formed with rather smooth variations at the other. These deformations gradually disappear in the deep H-phase (after {approx}15 ms from the transition) and the profiles inside the ETB become similar at both sections. The deformation seems linked to the presence of a non-rotating magnetic island at the rational surface of the rotational transform {iota}/2{pi} = 1.

  16. Regulatory review and barriers for the electricity supply system for distributed generation in EU-15

    DEFF Research Database (Denmark)

    Ropenus, Stephanie; Skytte, Klaus

    2005-01-01

    When distributed electricity supply surpasses a particular level, it can no longer be ignored in planning and operation of the electricity networks. Therefore, improvements of the regulatory framework of the electricity networks are required along with the growth of the electricity supply from di...... distributed generation. This paper reviews the current regulation of the grids with respect to distributed generation in EU-15 Member States and compares the different systems. Several barriers are identified.......When distributed electricity supply surpasses a particular level, it can no longer be ignored in planning and operation of the electricity networks. Therefore, improvements of the regulatory framework of the electricity networks are required along with the growth of the electricity supply from...

  17. Microstructure Evolution and Durability of Advanced Environmental Barrier Coating Systems for SiC/SiC Ceramic Matrix Composites

    Science.gov (United States)

    Zhu, Dongming; Evans, Laura J.; McCue, Terry R.; Harder, Bryan

    2016-01-01

    Environmental barrier coated SiC-SiC ceramic matrix composites (CMCs) systems will play a crucial role in next generation turbine engines for hot-section component applications because of their ability to significantly increase engine operating temperatures with improved efficiency, reduce engine weight and cooling requirements. Advanced HfO2 and rare earth silicate environmental barrier coatings (EBCs), along with multicomponent hafnium and rare earth silicide EBC bond coats have been developed. The coating degradation mechanisms in the laboratory simulated engine thermal cycling, and fatigue-creep operating environments are also being investigated. This paper will focus on the microstructural and compositional evolutions of an advanced environmental barrier coating system on a SiC-SiC CMC substrate during the high temperature simulated durability tests, by using a Field Emission Gun Scanning Electron Microscopy, Energy Dispersive Spectroscopy (EDS) and Wavelength Dispersive Spectroscopy (WDS). The effects of Calcium-Magnesium-Alumino-Silicate (CMAS) from road sand or volcano-ash deposits on the degradation mechanisms of the environmental barrier coating systems will also be discussed. The detailed analysis results help understand the EBC-CMC system performance, aiming at the durability improvements to achieve more robust, prime-reliant environmental barrier coatings.

  18. Achieving and sustaining automated health data linkages for learning systems: barriers and solutions.

    Science.gov (United States)

    Van Eaton, Erik G; Devlin, Allison B; Devine, Emily Beth; Flum, David R; Tarczy-Hornoch, Peter

    2014-01-01

    Delivering more appropriate, safer, and highly effective health care is the goal of a learning health care system. The Agency for Healthcare Research and Quality (AHRQ) funded enhanced registry projects: (1) to create and analyze valid data for comparative effectiveness research (CER); and (2) to enhance the ability to monitor and advance clinical quality improvement (QI). This case report describes barriers and solutions from one state-wide enhanced registry project. The Comparative Effectiveness Research and Translation Network (CERTAIN) deployed the commercially available Amalga Unified Intelligence System™ (Amalga) as a central data repository to enhance an existing QI registry (the Automation Project). An eight-step implementation process included hospital recruitment, technical electronic health record (EHR) review, hospital-specific interface planning, data ingestion, and validation. Data ownership and security protocols were established, along with formal methods to separate data management for QI purposes and research purposes. Sustainability would come from lowered chart review costs and the hospital's desire to invest in the infrastructure after trying it. CERTAIN approached 19 hospitals in Washington State operating within 12 unaffiliated health care systems for the Automation Project. Five of the 19 completed all implementation steps. Four hospitals did not participate due to lack of perceived institutional value. Ten hospitals did not participate because their information technology (IT) departments were oversubscribed (e.g., too busy with Meaningful Use upgrades). One organization representing 22 additional hospitals expressed interest, but was unable to overcome data governance barriers in time. Questions about data use for QI versus research were resolved in a widely adopted project framework. Hospitals restricted data delivery to a subset of patients, introducing substantial technical challenges. Overcoming challenges of idiosyncratic EHR

  19. AskFuse Origins: System Barriers to Providing the Research That Public Health Practice and Policy Partners Say They Need

    Science.gov (United States)

    Rushmer, Rosemary; Shucksmith, Janet

    2018-01-01

    In this paper the development of askFuse is used as a case study to illustrate contextual and system barriers to universities providing useful, usable and timely research evidence in response to local practice and policy partners' stated public health research needs. Entrenched systems (research excellence framework, academic career pathways,…

  20. Electro-Catalysis System for Biodiesel Synthesis from Palm Oil over Dielectric-Barrier Discharge Plasma Reactor

    Directory of Open Access Journals (Sweden)

    Istadi Istadi

    2014-07-01

    Full Text Available Biodiesel synthesis reaction routes from palm oil using plasma electro-catalysis process over Dielectric-Barrier Discharge (DBD plasma reactor were studied. The study was focused on finding possible reaction mechanism route during plasma electro-catalysis process. The prediction was performed based on the changes of Gas Chromatography Mass Spectrometer (GC-MS and Fourier Transform Infra Red (FT-IR analyses to the biodiesel products with respect to time length of plasma treatment. It was found that main reaction mechanism occurred in the plasma electro-catalysis system was non-thermal pyrolysis rather than transesterification. The main reactions within the plasma treatment were due to collision between high energetic electrons (supplied from high voltage power supply through high voltage electrode and the reaction mixtures. The high energetic electrons affected the electrons pair of covalent bonding to be excited or dissociated even ionized at higher energy. Therefore, this plasma electro-catalysis system was promising for biodiesel synthesis from vegetable oils due to only very short time reaction was needed, even no need a catalyst, no soap formation, and no glycerol by-product. This system could produce fatty acid methyl ester yield of 75.65% at 120 seconds and other possible chemicals, such as alkynes, alkanes, esters, carboxylic acid, and aldehydes. However, during the plasma process, the reaction mechanisms were still difficult to be controlled due the action of available high energetic electrons. The advanced studies on how to control the reaction mechanism selectively in the plasma electro-catalysis will be published elsewhere. © 2014 BCREC UNDIP. All rights reservedReceived: 23rd January 2014; Revised: 20th March 2014; Accepted: 23rd March 2014[How to Cite: Istadi, I., Yudhistira, A.D., Anggoro, D.D., Buchori, L. (2014. Electro-Catalysis System for Biodiesel Synthesis from Palm Oil over Dielectric-Barrier Discharge Plasma Reactor

  1. Creep Behavior of Hafnia and Ytterbium Silicate Environmental Barrier Coating Systems on SiC/SiC Ceramic Matrix Composites

    Science.gov (United States)

    Zhu, Dongming; Fox, Dennis S.; Ghosn, Louis J.; Harder, Bryan

    2011-01-01

    Environmental barrier coatings will play a crucial role in future advanced gas turbine engines because of their ability to significantly extend the temperature capability and stability of SiC/SiC ceramic matrix composite (CMC) engine components, thus improving the engine performance. In order to develop high performance, robust coating systems for engine components, appropriate test approaches simulating operating temperature gradient and stress environments for evaluating the critical coating properties must be established. In this paper, thermal gradient mechanical testing approaches for evaluating creep and fatigue behavior of environmental barrier coated SiC/SiC CMC systems will be described. The creep and fatigue behavior of Hafnia and ytterbium silicate environmental barrier coatings on SiC/SiC CMC systems will be reported in simulated environmental exposure conditions. The coating failure mechanisms will also be discussed under the heat flux and stress conditions.

  2. Selecting personnel to work on the interactive graphics system

    International Nuclear Information System (INIS)

    Norton, F.J.

    1979-01-01

    The paper established criteria for the selection of personnel to work on the interactive graphics system and mentions some of human behavioral patterns that are created by the implementation of graphic systems. Some of the social and educational problems associated with the interactive graphics system will be discussed. The project also provided for collecting objective data which would be useful in assessing the benefits of interactive graphics systems

  3. Selecting personnel to work on the interactive graphics system

    Energy Technology Data Exchange (ETDEWEB)

    Norton, F.J.

    1979-11-30

    The paper established criteria for the selection of personnel to work on the interactive graphics system and mentions some of human behavioral patterns that are created by the implementation of graphic systems. Some of the social and educational problems associated with the interactive graphics system will be discussed. The project also provided for collecting objective data which would be useful in assessing the benefits of interactive graphics systems.

  4. Engineered barrier development for a nuclear waste repository in basalt

    International Nuclear Information System (INIS)

    Smith, M.J.

    1980-05-01

    The BWIP Engineered Barrier Program has been developed to provide an integrated approach to the development of site-specific Engineered Barrier assemblages for a repository located in basalt. The goal of this program is to specify engineered and natural barriers which will ensure that nuclear and non-radioactive hazardous materials emplaced in a repository in basalt do not exceed acceptable rates of release to the biosphere. A wide range of analytical and experimental activities related to the basalt repository environment, waste package environment, waste/barrier/rock interactions, and barrier performance assessment provide the basis for selection of systems capable of meeting licensing requirements. Work has concentrated on specifying and testing natural and man-made materials which can be used to plug boreholes in basalt and which can be used as multiple barriers to surround nuclear waste forms and containers. The Engineered Barriers Program is divided into two major activities: multiple barrier studies and borehole plugging. 8 figures, 4 tables

  5. Stochastic resonance and vibrational resonance in an excitable system: The golden mean barrier

    International Nuclear Information System (INIS)

    Stan, Cristina; Cristescu, C.P.; Alexandroaei, D.; Agop, M.

    2009-01-01

    We report on stochastic resonance and vibrational resonance in an electric charge double layer configuration as usually found in electrical discharges, biological cell membranes, chemical systems and nanostructures. The experiment and numerical computation show the existence of a barrier expressible in terms of the golden mean above which the two phenomena do not take place. We consider this as new evidence for the importance of the golden mean criticality in the oscillatory dynamics, in agreement with El Naschie's E-infinity theory. In our experiment, the dynamics of a charge double layer generated in the inter-anode space of a twin electrical discharge is investigated under noise-harmonic and harmonic-harmonic perturbations. In the first case, a Gaussian noise can enhance the response of the system to a weak injected periodic signal, a clear mark of stochastic resonance. In the second case, similar enhancement can appear if the noise is replaced by a harmonic perturbation with a frequency much higher than the frequency of the weak oscillation. The amplitude of the low frequency oscillation shows a maximum versus the amplitude of the high frequency perturbation demonstrating vibrational resonance. In order to model these dynamics, we derived an excitable system by modifying a biased van der Pol oscillator. The computational study considers the behaviour of this system under the same types of perturbation as in the experimental investigations and is found to give consistent results in both situations.

  6. The intestinal complement system in inflammatory bowel disease: Shaping intestinal barrier function.

    Science.gov (United States)

    Sina, Christian; Kemper, Claudia; Derer, Stefanie

    2018-06-01

    The complement system is part of innate sensor and effector systems such as the Toll-like receptors (TLRs). It recognizes and quickly systemically and/or locally respond to microbial-associated molecular patterns (MAMPs) with a tailored defense reaction. MAMP recognition by intestinal epithelial cells (IECs) and appropriate immune responses are of major importance for the maintenance of intestinal barrier function. Enterocytes highly express various complement components that are suggested to be pivotal for proper IEC function. Appropriate activation of the intestinal complement system seems to play an important role in the resolution of chronic intestinal inflammation, while over-activation and/or dysregulation may worsen intestinal inflammation. Mice deficient for single complement components suffer from enhanced intestinal inflammation mimicking the phenotype of patients with chronic inflammatory bowel disease (IBD) such as Crohn's disease (CD) or ulcerative colitis (UC). However, the mechanisms leading to complement expression in IECs seem to differ markedly between UC and CD patients. Hence, how IECs, intestinal bacteria and epithelial cell expressed complement components interact in the course of IBD still remains to be mostly elucidated to define potential unique patterns contributing to the distinct subtypes of intestinal inflammation observed in CD and UC. Copyright © 2018 Elsevier Ltd. All rights reserved.

  7. Probabilistic common cause failure modeling for auxiliary feedwater system after the introduction of flood barriers

    International Nuclear Information System (INIS)

    Zheng, Xiaoyu; Yamaguchi, Akira; Takata, Takashi

    2013-01-01

    Causal inference is capable of assessing common cause failure (CCF) events from the viewpoint of causes' risk significance. Authors proposed the alpha decomposition method for probabilistic CCF analysis, in which the classical alpha factor model and causal inference are integrated to conduct a quantitative assessment of causes' CCF risk significance. The alpha decomposition method includes a hybrid Bayesian network for revealing the relationship between component failures and potential causes, and a regression model in which CCF parameters (global alpha factors) are expressed by explanatory variables (causes' occurrence frequencies) and parameters (decomposed alpha factors). This article applies this method and associated databases needed to predict CCF parameters of auxiliary feedwater (AFW) system when defense barriers against internal flood are introduced. There is scarce operation data for functionally modified safety systems and the utilization of generic CCF databases is of unknown uncertainty. The alpha decomposition method has the potential of analyzing the CCF risk of modified AFW system reasonably based on generic CCF databases. Moreover, the sources of uncertainty in parameter estimation can be studied. An example is presented to demonstrate the process of applying Bayesian inference in the alpha decomposition process. The results show that the system-specific posterior distributions for CCF parameters can be predicted. (author)

  8. Differential Rollover Risk in Vehicle-to-Traffic Barrier Collisions

    Science.gov (United States)

    Gabauer, Douglas J.; Gabler, Hampton C.

    2009-01-01

    In the roadside safety community, there has been debate over the influence of vehicle and barrier type on rollover rates in traffic barrier crashes. This study investigated rollover rates between sport utility vehicles (SUVs), pickup trucks, and cars in vehicle-traffic barrier crashes and has examined the effect of barrier type on rollover risk for concrete barrier and metal barrier impacts. The analysis included 955 barrier impact cases that were selected from 11-years of in-depth crash data available through the National Automotive Sampling System (NASS) / Crashworthiness Data System (CDS). In real world tow-away level longitudinal barrier collisions, the most important predictors of vehicle rollover were found to be vehicle type and whether the vehicle was tracking prior to barrier impact. Based on binary logistic regression, SUVs were found to have 8 times the risk of rollover as cars in barrier impacts. Although pickups were found to have an increased risk of rollover compared to cars, the risk was not as pronounced as that found for SUVs. This finding has direct implications for the full scale crash testing of longitudinal barriers as the testing procedures have been predicated on the assumption that the pickup truck provides a critical or worst case impact scenario. In towaway crashes, our study does not support the notion that concrete barriers have a higher risk of vehicle rollover than metal beam barriers. PMID:20184839

  9. Development of a alpha spectrometer system with the surface barrier detector

    International Nuclear Information System (INIS)

    Alencar, Marcus Alexandre Vallini de

    1994-04-01

    The aim of this work is the development of an α spectrometer of low cost and home made technology. The spectrometer is mounted in a double NIM module and includes a surface barrier detector and dedicate electronic system. Six barrier surface detectors were made, three of which with η type silicon wafer 3350 Ω.cm, 270mm 2 and three other with ρ type silicon wafer 5850 Ω.cm and 220mm 2 . The rectifier and the ohmic contacts were prepared at high vacuum (10 -2 to 10 -3 Pa) evaporation with 40μg/cm 2 of Au and Al respectively for the η type detectors, and with Al and Au respectively for the ρ type detectors. The electronic system is composed by a low noise charge sensitive preamplifier with the operational amplifier LF-356 mounted with 1OOMΩ feedback resistor and a 0.5 pF capacitor. The linear amplifier is also based in the LF-356 and the LM-310 operational amplifier. The bipolar output is formatted through a (CR) 2- (RC) 4 shaping network and the unipolar output is obtained through a CR-(RC) 4 shaping system which is sufficient to realize a almost true Gaussian shaping pulse with a time constant of 3.0μs. This format was chosen because we can expect a low counting rate and the gaussian pulse can improve the signal/noise ratio. The first CR differentiation has also a active pole-zero cancellation network.The resolution of detectors for 241 Am α particles at room temperature (24 degree) vary 21 to 44 keV FWHM. The electronic noise of the noise of the system is 7.5 keV FWHM at OpF input capacitance. The overall resolution of the spectrometer was found to be 62 keV FWHM at room temperature. The simplicity of the electronic system, the low cost of the construction and the overall resolution show that this alpha spectrometer can be readily used in measurements where high resolution is not a premium. (author)

  10. Measure Guideline: Selecting Ventilation Systems for Existing Homes

    Energy Technology Data Exchange (ETDEWEB)

    Aldrich, Robb [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2014-02-01

    This document addresses adding -or improving - mechanical ventilation systems to existing homes. The purpose of ventilation is to remove contaminants from homes, and this report discusses where, when, and how much ventilation is appropriate in a home, including some discussion of relevant codes and standards. Advantages, disadvantages, and approximate costs of various system types are presented along with general guidelines for implementing the systems in homes. CARB intends for this document to be useful to decision makers and contractors implementing ventilation systems in homes. Choosing the "best" system is not always straightforward; selecting a system involves balancing performance, efficiency, cost, required maintenance, and several other factors. It is the intent of this document to assist contractors in making more informed decisions when selecting systems. Ventilation is an integral part of a high-performance home. With more air-sealed envelopes, a mechanical means of removing contaminants is critical for indoor environmental quality and building durability.

  11. A DESIGN STUDY OF AN INNOVATIVE BARRIER SYSTEM FOR PERSONAL PARKING LOTS

    OpenAIRE

    BÖRKLÜ, Hüseyin; KALYON, Sadık

    2018-01-01

    The increase in the number of cars made it necessary to protectthe parking areas. This research includes a literature review aboutcommercially available barriers, which are arm barriers, rising bollards, chainbarriers, automatic and manual private barriers from the point of common andside-by-side parking lots. Their advantages and disadvantages are evaluated.After the literature review work, a design requirements list for a car parkprotector, which includes important and strong properties of ...

  12. Changes in skin barrier during treatment with systemic alitretinoin: focus on skin susceptibility and stratum corneum ceramides

    DEFF Research Database (Denmark)

    Jungersted, J.M.; Høgh, Julie Kaae; Hellgren, Lars

    2010-01-01

    ) was performed on the volar forearm and evaluated by trans-epidermal water loss (TEWL), erythema, and a cyanoacrylate skin sample was obtained for lipid analysis. We found no significant changes in response to SLS irritation as evaluated by TEWL and erythema, after treatment with alitretinoin for 2 months......Alitretinoin is a new drug for systemic treatment of chronic hand eczema. Previous functional tests of skin topically treated with retinoids have indicated impaired skin barrier function, but no data are available on barrier parameters after systemic alitretinoin treatment. To investigate...

  13. Information barriers

    International Nuclear Information System (INIS)

    Fuller, J.L.; Wolford, J.

    2001-01-01

    Full text: An information barrier (IB) consists of procedures and technology that prevent the release of sensitive information during a joint inspection of a sensitive nuclear item, and provides confidence that the measurement system into which it has been integrated functions exactly as designed and constructed. Work in the U.S. on radiation detection system information barriers dates back at least to 1990, even though the terminology is more recent. In January 1999 the Joint DoD-DOE Information Barrier Working Group was formed in the United States to help coordinate technical efforts related to information barrier R and D. This paper presents an overview of the efforts of this group, by its Chairs, as well as recommendations for further information barrier R and D. Progress on the demonstration of monitoring systems containing IBs is also provided. From the U.S. perspective, the basic, top-level functional requirements for the information barrier portion of an integrated radiation signature-information barrier inspection system are twofold: The host must be assured that his classified information is protected from disclosure to the inspecting party; and The inspecting party must be confident that the integrated inspection system measures, processes, and presents the radiation-signature-based measurement conclusion in an accurate and reproducible manner. It is the position of the United States that in the absence of any agreement to share classified nuclear weapons design information in the conduct of an inspection regime, the requirement to protect host country classified warhead design information is paramount and admits no tradeoff versus the confidence provided to the inspecting party in the accuracy and reproducibility of the measurements. The U.S. has reached an internal consensus on several critical design elements that define a general standard for radiation signature information barrier design. These criteria have stood the test of time under intense

  14. AVNG System Software-Attribute Verification System with Information Barriers for Mass Isotopic Measurements

    International Nuclear Information System (INIS)

    Elmont, T.H.; Langner, Diana C.; MacArthur, D.W.; Mayo, D.R.; Smith, M.K.; Modenov, A.

    2005-01-01

    This report describes the software development for the plutonium attribute verification system - AVNG. A brief synopsis of the technical solution for the measurement system is presented. The main tasks for the software development that is underway are formulated. The development tasks are shown in software structural flowcharts, measurement system state diagram and a description of the software. The current status of the AVNG software development is elucidated.

  15. Combined photovoltaic and solar-thermal systems: overcoming barriers to market acceptance. Paper no. IGEC-1-136

    International Nuclear Information System (INIS)

    Collins, M.R.

    2005-01-01

    In 1997, the International Energy Association's (IEA) Photovoltaic Power Systems Program (PVSP) initiated IEA Task 7 to evaluate the technical status of combined Photovoltaic and Solar-Thermal systems (PV/T), and to formulate a roadmap for future development. Because the Task was initiated by the PVSP, however, individuals from the Solar Heating and Cooling Program (SHCP) were not invited to participate, and the Task Group lacked any significant expertise with solar-thermal systems. When the Task submitted its final report in 2002, it consisted of an accounting of existing systems and a list of the perceived market barriers. Without input from the SHCP, however, no move could be made to actually address those barriers. IEA Task 7, however, did recognize that the participation of the SHCP was needed, and in 1999 made an effort to initiate some discussion between the PVSP and the SHCP. The result was IEA Task 35 - PV/T Systems, which met for the first time in January of 2005. The new group intends to reevaluate the findings of Task 7, and to develop the means by which these market barriers can be overcome. The current discussion will provide an overview of existing and potential PV/T systems and their technical status. Further, it will report on the methodology established by the Task 35 work group to overcome the aforementioned market barriers. (author)

  16. Examining Barriers to Internationalisation Created by Diverse Systems and Structures in Vocational Education and Training

    Directory of Open Access Journals (Sweden)

    Angela Joy Shaw

    2016-08-01

    Full Text Available In a global society, all educational sectors need to recognise internationalism as a core, foundational principle. Whilst most educational sectors are taking up that challenge, vocational education and training (VET is still being pulled towards the national agenda in terms of its structures and systems, and the policies driving it, disadvantaging those who graduate from VET, those who teach in it, and the businesses and countries that connect with it. This paper poses questions about the future of internationalisation in the sector. It examines whether there is a way to create a VET system that meets its primary point of value, to produce skilled workers for the local labour market, while still benefitting those graduates by providing international skills and knowledge, gained from VET institutions that are international in their outlook. The paper examines some of the key barriers created by systems and structures in VET to internationalisation and suggests that the efforts which have been made to address the problem have had limited success. It suggests that only a model which gives freedom to those with a direct vested interest, students, teachers, trainers and employers, to pursue international co-operation and liaison will have the opportunity to succeed.

  17. A method for risk analysis across governance systems: a Great Barrier Reef case study

    International Nuclear Information System (INIS)

    Dale, Allan; Vella, Karen; Potts, Ruth; Pressey, Robert L; Brodie, Jon; Yorkston, Hugh

    2013-01-01

    Healthy governance systems are key to delivering sound environmental management outcomes from global to local scales. There are, however, surprisingly few risk assessment methods that can pinpoint those domains and sub-domains within governance systems that are most likely to influence good environmental outcomes at any particular scale, or those if absent or dysfunctional, most likely to prevent effective environmental management. This paper proposes a new risk assessment method for analysing governance systems. This method is then tested through its preliminary application to a significant real-world context: governance as it relates to the health of Australia’s Great Barrier Reef (GBR). The GBR exists at a supra-regional scale along most of the north eastern coast of Australia. Brodie et al (2012 Mar. Pollut. Bull. 65 81–100) have recently reviewed the state and trend of the health of the GBR, finding that overall trends remain of significant concern. At the same time, official international concern over the governance of the reef has recently been signalled globally by the International Union for the Conservation of Nature (IUCN). These environmental and political contexts make the GBR an ideal candidate for use in testing and reviewing the application of improved tools for governance risk assessment. (letter)

  18. Feasibility study of a single-element transcranial focused ultrasound system for blood-brain barrier opening

    Science.gov (United States)

    Marquet, Fabrice; Tung, Yao-Sheng; Teichert, Tobias; Ferrera, Vincent P.; Konofagou, Elisa E.

    2012-10-01

    The blood-brain barrier (BBB) is a specialized vascular system that impedes entry of all large and the vast majority of small molecules including the most potent CNS disease therapeutic agents from entering from the lumen into the brain parenchyma. Microbubble-enhanced, focused ultrasound (ME-FUS) has been previously shown to disrupt noninvasively, selectively, and transiently the BBB in small animals in vivo. The study addresses the focusing properties of single-element transducers at intermediate frequencies (500 kHz) through primate and human skulls, targeting clinically relevant targets extracted from 3D brain atlases such as the hippocampus and the basal ganglia, which are typically affected by early Alzheimer's and Parkinson's disease, respectively. A preliminary in vivo study was performed to study the frequency dependence of BBB opening parameters in mice. Then, feasibility of transcranial ME-FUS BBB opening in non-human primates was demonstrated with subsequent BBB recovery. Sonications were combined with two different types of microbubbles (custom made 4-5 μm and Definity®). 3T MRI was used to confirm the BBB disruption and to assess brain damage.

  19. Systemic barriers accessing HIV treatment among people who inject drugs in Russia: a qualitative study.

    Science.gov (United States)

    Sarang, Anya; Rhodes, Tim; Sheon, Nicolas

    2013-10-01

    Achieving 'universal access' to antiretroviral HIV treatment (ART) in lower income and transitional settings is a global target. Yet, access to ART is shaped by local social condition and is by no means universal. Qualitative studies are ideally suited to describing how access to ART is socially situated. We explored systemic barriers to accessing ART among people who inject drugs (PWID) in a Russian city (Ekaterinburg) with a large burden of HIV treatment demand. We undertook 42 in-depth qualitative interviews with people living with HIV with current or recent experience of injecting drug use. Accounts were analysed thematically, and supplemented here with an illustrative case study. Three core themes were identified: 'labyrinthine bureaucracy' governing access to ART; a 'system Catch 22' created by an expectation that access to ART was conditional upon treated drug use in a setting of limited drug treatment opportunity; and 'system verticalization', where a lack of integration across HIV, tuberculosis (TB) and drug treatment compromised access to ART. Taken together, we find that systemic factors play a key role in shaping access to ART with the potential adverse effects of reproducing treatment initiation delay and disengagement from treatment. We argue that meso-level systemic factors affecting access to ART for PWID interact with wider macro-level structural forces, including those related to drug treatment policy and the social marginalization of PWID. We note the urgent need for systemic and structural changes to improve access to ART for PWID in this setting, including to simplify bureaucratic procedures, foster integrated HIV, TB and drug treatment services, and advocate for drug treatment policy reform.

  20. Operator psychological selection system for nuclear power plant

    International Nuclear Information System (INIS)

    He Xuhong; Huang Xiangrui

    2004-01-01

    Based on a detailed job analysis of nuclear power plant operator including operation procedures analysis, interview with personnel familiar with operator job, and 9 events happened in the past in the plant involved operator error analysis, several operator work characteristics and performance influence factors are obtained. According to these specific characteristics and factors, referring to the psychological selection research results in the other related critical occupational fields, a full psychological selection system of nuclear power plant operator is forwarded in this paper, including 21 dimensions in 3 facets as general psychological ability, personality and psychological healthy. Practical measurement methods for the proposed selection dimensions are discussed in the end

  1. A multi-attribute decision model for portfolio selection aiming to replace technologies in industrial motor systems

    International Nuclear Information System (INIS)

    Vanderley Herrero Sola, Antonio; Mota, Caroline Maria de Miranda

    2012-01-01

    Highlights: ► We propose a multicriteria decision model for technology replacement. ► We prioritize induction motors in order to improve the energy efficiency. ► The best portfolio of options is selected based on decision maker’s utilities. ► The model contribute to surpass some organizational barriers. - Abstract: The energy efficient technologies offered by the market are in constant evolution, but their insertion in the productive sector comes up against organizational barriers, which obstruct decision making in firms. This paper proposes a multicriteria decision model in order to replace technologies in industrial energy systems, regarding organizational barriers for energy efficiency. The proposed model is applied in industrial motor systems, using Multi-Attribute Utility Theory (MAUT), in order to select the best portfolio of options based on the decision maker’s utilities. Portfolios of options from the prioritized set of motors compiled by the operational area of the studied industry are analyzed, including diverse suppliers and different classes of motors. The results show that it is essential to structure the proposed model in two steps, beginning with the operational level, to ensure that important technologies for the production system are prioritized, thus preserving the interests of the organization and improving the efficiency of industrial energy systems.

  2. UK innovation systems for new and renewable energy technologies: drivers, barriers and systems failures

    International Nuclear Information System (INIS)

    Foxon, T.J.; Gross, R.; Chase, A.; Howes, J.; Arnall, A.; Anderson, D.

    2005-01-01

    A better understanding of the systemic processes by which innovation occurs is useful, both conceptually and to inform policy-making in support of innovation in more sustainable technologies. This paper analyses current innovation systems in the UK for a range of new and renewable energy technologies, and generates policy recommendations for improving the effectiveness of these innovation systems. Although incentives are in place in the UK to encourage innovation in these technologies, system failures - or 'gaps' - are identified in moving technologies along the innovation chain, preventing their successful commercialisation. Sustained investment will be needed for these technologies to achieve their potential. It is argued that a stable and consistent policy framework is required to help create the conditions for this. In particular, such a framework should be aimed at improving risk/reward ratios for demonstration and pre-commercial stage technologies. This would enhance positive expectations, stimulate learning effects leading to cost reductions, and increase the likelihood of successful commercialisation

  3. Morphological response of a barrier island system on a catastrophic event

    DEFF Research Database (Denmark)

    Fruergaard, Mikkel; Kroon, Aart

    2016-01-01

    storms are capable of moving large amounts of sediments over relatively short time-periods and can create barrier shoals, whereas moderate storms mostly rework the shoal or barrier and create more local erosion and/or landward migration. Catastrophic storms substantially influence long-term and large...

  4. On the relationship between perceived importance of ERP systems selection characteristics and satisfaction with selected ERP systems in these characteristics

    DEFF Research Database (Denmark)

    Sudzina, Frantisek; Pucihar, Andreja; Lenart, Gregor

    2011-01-01

    of the relationship between the two. The paper focuses on the correlation between importance of ERP system selection criteria and the level of satisfaction with the chosen ERP systems in these characteristics. The research hypothesis is that there exists a correlation between the two. The analysis presented...

  5. Determining Barriers and Facilitators Associated With Willingness to Use a Personal Health Information Management System to Support Worksite Wellness Programs.

    Science.gov (United States)

    Neyens, David M; Childers, Ashley Kay

    2017-07-01

    To determine the barriers and facilitators associated with willingness to use personal health information management (PHIM) systems to support an existing worksite wellness program (WWP). The study design involved a Web-based survey. The study setting was a regional hospital. Hospital employees comprised the study subjects. Willingness, barriers, and facilitators associated with PHIM were measured. Bivariate logit models were used to model two binary dependent variables. One model predicted the likelihood of believing PHIM systems would positively affect overall health and willingness to use. Another predicted the likelihood of worrying about online security and not believing PHIM systems would benefit health goals. Based on 333 responses, believing PHIM systems would positively affect health was highly associated with willingness to use PHIM systems (p < .01). Those comfortable online were 7.22 times more willing to use PHIM systems. Participants in exercise-based components of WWPs were 3.03 times more likely to be willing to use PHIM systems. Those who worried about online security were 5.03 times more likely to believe PHIM systems would not help obtain health goals. Comfort with personal health information online and exercise-based WWP experience was associated with willingness to use PHIM systems. However, nutrition-based WWPs did not have similar effects. Implementation barriers relate to technology anxiety and trust in security, as well as experience with specific WWP activities. Identifying differences between WWP components and addressing technology concerns before implementation of PHIM systems into WWPs may facilitate improved adoption and usage.

  6. Barriers to the success of an electronic pharmacovigilance reporting system in Kenya: an evaluation three years post implementation.

    Science.gov (United States)

    Agoro, Oscar O; Kibira, Sarah W; Freeman, Jenny V; Fraser, Hamish S F

    2018-06-01

    Electronic pharmacovigilance reporting systems are being implemented in many developing countries in an effort to improve reporting rates. This study sought to establish the factors that acted as barriers to the success of an electronic pharmacovigilance reporting system in Kenya 3 years after its implementation. Factors that could act as barriers to using electronic reporting systems were identified in a review of literature and then used to develop a survey questionnaire that was administered to pharmacists working in government hospitals in 6 counties in Kenya. The survey was completed by 103 out of the 115 targeted pharmacists (89.5%) and included free-text comments. The key factors identified as barriers were: unavailable, unreliable, or expensive Internet access; challenges associated with a hybrid system of paper and electronic reporting tools; and system usability issues. Coordination challenges at the national pharmacovigilance center and changes in the structure of health management in the country also had an impact on the success of the electronic reporting system. Different personal, organizational, infrastructural, and reporting system factors affect the success of electronic reporting systems in different ways, depending on the context. Context-specific formative evaluations are useful in establishing the performance of electronic reporting systems to identify problems and ensure that they achieve the desired objectives. While several factors hindered the optimal use of the electronic pharmacovigilance reporting system in Kenya, all were considered modifiable. Effort should be directed toward tackling the identified issues in order to facilitate use and improve pharmacovigilance reporting rates.

  7. On the interfacial degradation mechanisms of thermal barrier coating systems: Effects of bond coat composition

    Energy Technology Data Exchange (ETDEWEB)

    Wu, R.T., E-mail: WU.Rudder@nims.go.jp [International Center for Young Scientists, National Institute for Materials Science, 1-2-1 Sengen, Tsukuba City, Ibaraki (Japan); Wang, X.; Atkinson, A. [Department of Materials, Imperial College London, Prince Consort Road, London SW7 2BP (United Kingdom)

    2010-10-15

    Thermal barrier coating (TBC) systems based on an electron beam physical vapour deposited, yttria-stabilized zirconia (YSZ) top coat and a substrate material of CMSX-4 superalloy were identically prepared to systematically study the behaviour of different bond coats. The three bond coat systems investigated included two {beta}-structured Pt-Al types and a {gamma}-{gamma}' type produced by Pt diffusion without aluminizing. Progressive evolution of stress in the thermally grown aluminium oxide (TGO) upon thermal cycling, and its relief by plastic deformation and fracture, were studied using luminescence spectroscopy. The TBCs with the LT Pt-Al bond coat failed by a rumpling mechanism that generated isolated cracks at the interface between the TGO and the YSZ. This reduced adhesion at this interface and the TBC delaminated when it could no longer resist the release of the stored elastic energy of the YSZ, which stiffened with time due to sintering. In contrast, the TBCs with Pt diffusion bond coats did not rumple, and the adhesion of interfaces in the coating did not obviously degrade. It is shown that the different failure mechanisms are strongly associated with differences in the high-temperature mechanical properties of the bond coats.

  8. On the compatibility of single crystal superalloys with a thermal barrier coating system

    Energy Technology Data Exchange (ETDEWEB)

    Wu, R.T. [Department of Materials, Imperial College London, Prince Consort Road, London SW7 2BP (United Kingdom); Reed, R.C. [Department of Materials, Imperial College London, Prince Consort Road, London SW7 2BP (United Kingdom)], E-mail: r.reed@birmingham.ac.uk

    2008-02-15

    The compatibility of three Co-containing prototype single crystal nickel-based superalloys with a thermal barrier coating (TBC) system is examined. These contain 2.1, 8.4 and 12.6 at.% Co; the concentrations of Al, Cr, Ta, W, Re, Hf are identical and chosen to be representative of advanced grades of these alloys. The TBC consists of an yttria-stabilized zirconia (YSZ) layer formed by electron beam physical vapour deposition (EB-PVD) and a bond coat made by electrodeposited platinum with a subsequent interdiffusion heat treatment - a so-called 'platinum-diffused' bond coat. The resistance to spallation of the TBC system is degraded as the Co content of the substrate increases. Wavelength-dispersive X-ray analysis and secondary ion mass spectrometry indicate that quantities of Co are present in the thermally grown oxide (TGO) by the time that failure occurs, this effect being most pronounced when the Co content of the substrate is high; the TGO is then more wavy and convoluted. The bond coat consists exclusively of the {gamma} and {gamma}' phases, with the balance shifting towards {gamma} with increasing thermal exposure; the loss of Al from the bond coat due to TGO formation means that the TGO is eventually in contact with the {gamma} phase solely, which is enriched in Co.

  9. Solving problems in social-ecological systems: definition, practice and barriers of transdisciplinary research.

    Science.gov (United States)

    Angelstam, Per; Andersson, Kjell; Annerstedt, Matilda; Axelsson, Robert; Elbakidze, Marine; Garrido, Pablo; Grahn, Patrik; Jönsson, K Ingemar; Pedersen, Simen; Schlyter, Peter; Skärbäck, Erik; Smith, Mike; Stjernquist, Ingrid

    2013-03-01

    Translating policies about sustainable development as a social process and sustainability outcomes into the real world of social-ecological systems involves several challenges. Hence, research policies advocate improved innovative problem-solving capacity. One approach is transdisciplinary research that integrates research disciplines, as well as researchers and practitioners. Drawing upon 14 experiences of problem-solving, we used group modeling to map perceived barriers and bridges for researchers' and practitioners' joint knowledge production and learning towards transdisciplinary research. The analysis indicated that the transdisciplinary research process is influenced by (1) the amount of traditional disciplinary formal and informal control, (2) adaptation of project applications to fill the transdisciplinary research agenda, (3) stakeholder participation, and (4) functional team building/development based on self-reflection and experienced leadership. Focusing on implementation of green infrastructure policy as a common denominator for the delivery of ecosystem services and human well-being, we discuss how to diagnose social-ecological systems, and use knowledge production and collaborative learning as treatments.

  10. Systemic delivery of blood-brain barrier-targeted polymeric nanoparticles enhances delivery to brain tissue.

    Science.gov (United States)

    Saucier-Sawyer, Jennifer K; Deng, Yang; Seo, Young-Eun; Cheng, Christopher J; Zhang, Junwei; Quijano, Elias; Saltzman, W Mark

    2015-01-01

    Delivery of therapeutic agents to the central nervous system is a significant challenge, hindering progress in the treatment of diseases such as glioblastoma. Due to the presence of the blood-brain barrier (BBB), therapeutic agents do not readily transverse the brain endothelium to enter the parenchyma. Previous reports suggest that surface modification of polymer nanoparticles (NPs) can improve their ability to cross the BBB, but it is unclear whether the observed enhancements in transport are large enough to enhance therapy. In this study, we synthesized two degradable polymer NP systems surface-modified with ligands previously suggested to improve BBB transport, and tested their ability to cross the BBB after intravenous injection in mice. All the NP preparations were able to cross the BBB, although generally in low amounts (brain uptake (∼0.8% of the injected dose): a block copolymer of polylactic acid and hyperbranched polyglycerol, surface modified with adenosine (PLA-HPG-Ad). PLA-HPG-Ad NPs provided controlled release of camptothecin, killing U87 glioma cells in culture. When administered intravenously in mice with intracranial U87 tumors, they failed to increase survival. These results suggest that enhancing NP transport across the BBB does not necessarily yield proportional pharmacological effects.

  11. A Fuzzy-MOORA approach for ERP system selection

    Directory of Open Access Journals (Sweden)

    Prasad Karande

    2012-07-01

    Full Text Available In today’s global and dynamic business environment, manufacturing organizations face the tremendous challenge of expanding markets and meeting the customer expectations. It compels them to lower total cost in the entire supply chain, shorten throughput time, reduce inventory, expand product choice, provide more reliable delivery dates and better customer service, improve quality, and efficiently coordinate demand, supply and production. In order to accomplish these objectives, the manufacturing organizations are turning to enterprise resource planning (ERP system, which is an enterprise-wide information system to interlace all the necessary business functions, such as product planning, purchasing, inventory control, sales, financial and human resources into a single system having a shared database. Thus to survive in the global competitive environment, implementation of a suitable ERP system is mandatory. However, selecting a wrong ERP system may adversely affect the manufacturing organization’s overall performance. Due to limitations in available resources, complexity of ERP systems and diversity of alternatives, it is often difficult for a manufacturing organization to select and install the most suitable ERP system. In this paper, two ERP system selection problems are solved using fuzzy multi-objective optimization on the basis of ratio analysis (MOORA method and it is observed that in both the cases, SAP is the best solution.

  12. Selective adsorption of ions in charged slit-systems

    Directory of Open Access Journals (Sweden)

    M.Valiskó

    2013-01-01

    Full Text Available We study the selective adsorption of various cations into a layered slit system using grand canonical Monte Carlo simulations. The slit system is formed by a series of negatively charged membranes. The electrolyte contains two kinds of cations with different sizes and valences modeled by charged hard spheres immersed in a continuum dielectric solvent. We present results for various cases depending on the combinations of the properties of the competing cations. We concentrate to the case when the divalent cations are larger than the monovalent cations. In this case, size and charge have counterbalancing effects, which results in interesting selectivity phenomena.

  13. Database system selection for marketing strategies support in information systems

    Directory of Open Access Journals (Sweden)

    František Dařena

    2007-01-01

    Full Text Available In today’s dynamically changing environment marketing has a significant role. Creating successful marketing strategies requires large amount of high quality information of various kinds and data types. A powerful database management system is a necessary condition for marketing strategies creation support. The paper briefly describes the field of marketing strategies and specifies the features that should be provided by database systems in connection with these strategies support. Major commercial (Oracle, DB2, MS SQL, Sybase and open-source (PostgreSQL, MySQL, Firebird databases are than examined from the point of view of accordance with these characteristics and their comparison in made. The results are useful for making the decision before acquisition of a database system during information system’s hardware architecture specification.

  14. Review of underground logistic systems in the Netherlands : An ex-post evaluation of barriers, enablers and spin-offs

    NARCIS (Netherlands)

    Wiegmans, B.W.; Visser, J.; Konings, R.; Pielage, B.J.A.

    2010-01-01

    Now, 10 years after the first plans, we analyse in this paper what has happened with Underground Logistic Systems (ULS). The major question in this paper is: Which barriers and enablers led to the failure of ULS and what ULS spin-offs can be found nowadays? Several factors can be classified as

  15. Monitoring active species in an atmospheric pressure dielectric-barrier discharge: Observation of the Herman-infrared system

    Czech Academy of Sciences Publication Activity Database

    Annušová, A.; Čermák, P.; Rakovský, Jozef; Martišovitš, V.; Veis, P.

    2017-01-01

    Roč. 57, č. 2 (2017), s. 67-75 ISSN 0863-1042 Institutional support: RVO:61388955 Keywords : dielectric-barrier discharge * Herman-infrared system * nitrogen Subject RIV: CF - Physical ; Theoretical Chemistry OBOR OECD: Physical chemistry Impact factor: 1.440, year: 2016

  16. Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system philadelphia chromosome positive leukemia

    NARCIS (Netherlands)

    K. Porkka (Kimmo); P. Koskenvesa (Perttu); T. Lundan (Tuija); J. Rimpiläinen (Johanna); S. Mustjoki (Satu); R. Smykla (Richard); R. Wild (Robert); R. Luo (Roger); M. Arnan (Montserrat); B. Brethon (Benoit); L. Eccersley (Lydia); H. Hjorth-Hansen (Henrik); M. Höglund (Martin); H. Klamova (Hana); H. Knutsen (Håvar); S. Parikh (Suhag); E. Raffoux (Emmanuel); F. Gruber (Franz); F. Brito-Babapulle (Finella); H. Dombret (Hervé); R.F. Duarte (Rafael); E. Elonen (Erkki); R. Paquette (Ron); C.M. Zwaan (Christian Michel); F.Y.F. Lee (Francis)

    2008-01-01

    textabstractAlthough imatinib, a BCR-ABL tyrosine kinase inhibitor, is used to treat acute Philadelphia chromosome-positive (Ph+) leukemia, it does not prevent central nervous system (CNS) relapses resulting from poor drug penetration through the blood-brain barrier. Imatinib and dasatinib (a

  17. Combined Thermomechanical and Environmental Durability of Environmental Barrier Coating Systems on SiC/SiC Ceramic Matrix Composites

    Science.gov (United States)

    Zhu, Dongming; Harder, Bryan; Bhatt, Ramakrishna

    2016-01-01

    Environmental barrier coatings (EBCs) and SiC/SiC ceramic matrix composites (CMCs) will play a crucial role in next generation turbine engines for hot-section component applications. The development of prime-reliant environmental barrier coatings is essential to the EBC-CMC system durability, ensuring the successful implementations of the high temperature and lightweight engine component technologies for engine applications.This paper will emphasize recent NASA environmental barrier coating and CMC developments for SiC/SiC turbine airfoil components, utilizing advanced coating compositions and processing methods. The emphasis has been particularly placed on thermomechanical and environment durability evaluations of EBC-CMC systems. We have also addressed the integration of the EBCs with advanced SiC/SiC CMCs, and studied the effects of combustion environments and Calcium-Magnesium-Alumino-Silicate (CMAS) deposits on the durability of the EBC-CMC systems under thermal gradient and mechanical loading conditions. Advanced environmental barrier coating systems, including multicomponent rare earth silicate EBCs and HfO2-Si based bond coats, will be discussed for the performance improvements to achieve better temperature capability and CMAS resistance for future engine operating conditions.

  18. A multi-purpose unit concept to integrate storage, transportation, and the engineered barrier system

    International Nuclear Information System (INIS)

    Hollaway, W.R.; Rozier, R.; Nitti, D.A.; Williams, J.R.

    1993-01-01

    The Multi-Purpose Unit (MPU) is a new concept for standardizing and integrating the waste management functions of spent fuel storage, transportation, and geologic disposal. The MPU concept would use one unit, composed of a relatively thick-walled inner canister with a multi-purpose overpack, to meet the requirements for storage in 10 CFR 72, transportation in 10 CFR 71, and the engineered barrier system in 10 CFR 60. The MPU concept differs from the recently proposed Multi-Purpose Canister (MPC) concept in that the MPU concept uses a single multi-purpose overpack for storage, transportation, and geologic disposal, while the MPC concept uses separate and unique overpacks for each of these system functions. A design concept for the MPU is presented along with an estimate of unit costs. An initial evaluation of overall system cost showed that the MPU concept could be economically competitive with the current reference system. The MPU concept provides the potential for significant reduction, simplification, and standardization of Civilian Radioactive Waste Management (CRWMS) facilities and operations, including those at the utilities, during waste acceptance and transportation, and at the Monitored Retrievable Storage (MRS) facility and the repository. The primary issues for the MPU concept relate to uncertainties with respect to licensing, and the programmatic risks associated with implementing the MPU concept before the repository design is finalized. The strong potential exhibited by the MPU concept demonstrates that this option merits additional development and should be considered in the next phase of work on multi-purpose concepts for the CRWMS

  19. Selecting a Relational Database Management System for Library Automation Systems.

    Science.gov (United States)

    Shekhel, Alex; O'Brien, Mike

    1989-01-01

    Describes the evaluation of four relational database management systems (RDBMSs) (Informix Turbo, Oracle 6.0 TPS, Unify 2000 and Relational Technology's Ingres 5.0) to determine which is best suited for library automation. The evaluation criteria used to develop a benchmark specifically designed to test RDBMSs for libraries are discussed. (CLB)

  20. Selective maintenance of multi-state systems with structural dependence

    International Nuclear Information System (INIS)

    Dao, Cuong D.; Zuo, Ming J.

    2017-01-01

    This paper studies the selective maintenance problem for multi-state systems with structural dependence. Each component can be in one of multiple working levels and several maintenance actions are possible to a component in a maintenance break. The components structurally form multiple hierarchical levels and dependence groups. A directed graph is used to represent the precedence relations of components in the system. A selective maintenance optimization model is developed to maximize the system reliability in the next mission under time and cost constraints. A backward search algorithm is used to determine the assembly sequence for a selective maintenance scenario. The maintenance model helps maintenance managers in determining the best combination of maintenance activities to maximize the probability of successfully completing the next mission. Examples showing the use of the proposed method are presented. - Highlights: • A selective maintenance model for multi-state systems is proposed considering both economic and structural dependence. • Structural dependence is modeled as precedence relationship when disassembling components for maintenance. • Resources for disassembly and maintenance are evaluated using a backward search algorithm. • Maintenance strategies with and without structural dependence are analyzed. • Ignoring structural dependence may lead to over-estimation of system reliability.

  1. Silver deposition in the central nervous system and the hematoencephalic barrier studied with the electron microscope.

    Science.gov (United States)

    VAN BREEMEN, V L; CLEMENTE, C D

    1955-03-01

    For the purpose of studying the hematoencephalic barrier as it is concerned with silver circulating in the blood stream, silver nitrate was vitally administered to rats in their drinking water over periods of 6 to 8 months. The cerebrum, cerebellum, medulla, area postrema, and choroid plexus were prepared for light and electron microscopy. Silver deposition was found in the perivascular spaces in the choroid plexus, area postrema, in the medulla surrounding the area postrema, and in minute quantities in the cerebrum, cerebellum, and most of the medulla. Two levels of the hematoencephalic barrier were apparently demonstrated in our investigations. The endothelial linings of the vessels in the cerebrum, cerebellum, and medulla constitute the first threshold of the hematoencephalic barrier (specifically here, blood-brain barrier). The cell membranes adjacent to the perivascular spaces form the second threshold, as follows:-the neuroglial cell membranes in the cerebrum, cerebellum, and medulla (blood-brain barrier); the membranes of the neuroglial cells in the area postrema (blood-brain barrier); and the membranes of the epithelial cells of the choroid plexus (blood-cerebrospinal fluid barrier). This study deals with silver deposition and does not infer that the penetration of ionic silver, if present in the blood stream, would necessarily be limited to the regions described. Bleb-like structures were observed to cover the epithelial cell surfaces in the choroid plexus. They may be cellular projections increasing the cell surface area or they may be secretory droplets.

  2. The socio-technical barriers to Solar Home Systems (SHS) in Papua New Guinea: 'Choosing pigs, prostitutes, and poker chips over panels'

    International Nuclear Information System (INIS)

    Sovacool, Benjamin K.; D'Agostino, Anthony L.; Jain Bambawale, Malavika

    2011-01-01

    This study explores the socio-technical barriers to Solar Home Systems (SHS) in Papua New Guinea. The authors collected primary data through semi-structured research interviews conducted over the course of February 2010-April 2010. Respondents included government officials, financiers, planners, commercial distributors and companies, teachers and rural villagers in addition to members of civil society, academics, consultants, and trainers. These interviews were supplemented with site visits to Port Moresby, Goroka, and Madang, and field research in the villages of Akameku, Asaroka, Lufa, Kundiawa, Okifa, Simbu, and Talidig. The study draws from these interviews and visits to discuss four types of barriers. Technical barriers relate to substandard equipment and logistical problems. Economic barriers include high rates of poverty, misconceptions about the role of currency, and lack of financing. Political barriers include poor institutional capacity and a government commitment to fossil-fueled grid electrification. Social barriers encompass unrealistic expectations about what SHS can provide along with jealousy, theft, vandalism, and unfamiliarity with solar technology. - Research highlights: → Solar Home Systems (SHS) are impeded by a collection of different barriers in Papua New Guinea. → Technical barriers relate to substandard equipment and logistical problems. → Economic barriers include high rates of poverty, misconceptions about the role of currency, and lack of financing.→ Political barriers include poor institutional capacity and a government commitment to fossil-fueled grid electrification. → Social barriers encompass unrealistic expectations about what SHS can provide along with jealousy, theft, vandalism, and unfamiliarity with solar technology.

  3. The socio-technical barriers to Solar Home Systems (SHS) in Papua New Guinea: 'Choosing pigs, prostitutes, and poker chips over panels'

    Energy Technology Data Exchange (ETDEWEB)

    Sovacool, Benjamin K., E-mail: bsovacool@nus.edu.s [Lee Kuan Yew School of Public Policy, National University of Singapore, 469C Bukit Timah Road, Singapore 259772 (Singapore); D' Agostino, Anthony L.; Jain Bambawale, Malavika [Lee Kuan Yew School of Public Policy, National University of Singapore, 469C Bukit Timah Road, Singapore 259772 (Singapore)

    2011-03-15

    This study explores the socio-technical barriers to Solar Home Systems (SHS) in Papua New Guinea. The authors collected primary data through semi-structured research interviews conducted over the course of February 2010-April 2010. Respondents included government officials, financiers, planners, commercial distributors and companies, teachers and rural villagers in addition to members of civil society, academics, consultants, and trainers. These interviews were supplemented with site visits to Port Moresby, Goroka, and Madang, and field research in the villages of Akameku, Asaroka, Lufa, Kundiawa, Okifa, Simbu, and Talidig. The study draws from these interviews and visits to discuss four types of barriers. Technical barriers relate to substandard equipment and logistical problems. Economic barriers include high rates of poverty, misconceptions about the role of currency, and lack of financing. Political barriers include poor institutional capacity and a government commitment to fossil-fueled grid electrification. Social barriers encompass unrealistic expectations about what SHS can provide along with jealousy, theft, vandalism, and unfamiliarity with solar technology. - Research highlights: {yields} Solar Home Systems (SHS) are impeded by a collection of different barriers in Papua New Guinea. {yields} Technical barriers relate to substandard equipment and logistical problems. {yields} Economic barriers include high rates of poverty, misconceptions about the role of currency, and lack of financing.{yields} Political barriers include poor institutional capacity and a government commitment to fossil-fueled grid electrification. {yields} Social barriers encompass unrealistic expectations about what SHS can provide along with jealousy, theft, vandalism, and unfamiliarity with solar technology.

  4. Neural mechanisms of selective attention in the somatosensory system.

    Science.gov (United States)

    Gomez-Ramirez, Manuel; Hysaj, Kristjana; Niebur, Ernst

    2016-09-01

    Selective attention allows organisms to extract behaviorally relevant information while ignoring distracting stimuli that compete for the limited resources of their central nervous systems. Attention is highly flexible, and it can be harnessed to select information based on sensory modality, within-modality feature(s), spatial location, object identity, and/or temporal properties. In this review, we discuss the body of work devoted to understanding mechanisms of selective attention in the somatosensory system. In particular, we describe the effects of attention on tactile behavior and corresponding neural activity in somatosensory cortex. Our focus is on neural mechanisms that select tactile stimuli based on their location on the body (somatotopic-based attention) or their sensory feature (feature-based attention). We highlight parallels between selection mechanisms in touch and other sensory systems and discuss several putative neural coding schemes employed by cortical populations to signal the behavioral relevance of sensory inputs. Specifically, we contrast the advantages and disadvantages of using a gain vs. spike-spike correlation code for representing attended sensory stimuli. We favor a neural network model of tactile attention that is composed of frontal, parietal, and subcortical areas that controls somatosensory cells encoding the relevant stimulus features to enable preferential processing throughout the somatosensory hierarchy. Our review is based on data from noninvasive electrophysiological and imaging data in humans as well as single-unit recordings in nonhuman primates. Copyright © 2016 the American Physiological Society.

  5. STRATEGY FOR EVALUATION AND SELECTION OF SYSTEMS FOR ELECTRONIC LEARNING

    Directory of Open Access Journals (Sweden)

    Dubravka Mandušić

    2012-12-01

    Full Text Available Today`s technology supported and accelerated learning time requires constant and continuous acquisition of new knowledge. On the other hand, it does not leave enough time for additional education. Increasing number of E-learning systems, withdraws a need for precise evaluation of functionality that those systems provide; so they could be reciprocally compared. While implementing new systems for electronic learning, it is very important to pre-evaluate existing systems in order to select the one that meets all defined parameters, with low costs/investment. Proper evaluation can save time and money.

  6. Configuration Selection for Reconfigurable Control of Piecewise Affine Systems

    DEFF Research Database (Denmark)

    Tabatabaeipour, Mojtaba; Gholami, M.; Bak, T.

    2015-01-01

    the recongurability of the system and the optimal conguration in the architecture design phase. A recongurable control must ensure stability of the recongured system and, if possible, a graceful degradation in the performance. Therefore, in the proposed recongurability analysis, we consider both stabilizability......In this paper, the problem of conguration selection i.e. sensor/actuator placement for piecewise ane (PWA) systems subject to both sensor and actuator faults is considered. A method is proposed that provides a tool for the design phase to decide about the optimal placement of sensor/actuators where...... and performance of the system. The efficiency of the proposed method is demonstrated on several numerical examples...

  7. Designing a fuzzy expert system for selecting knowledge management strategy

    Directory of Open Access Journals (Sweden)

    Ameneh Khadivar

    2014-12-01

    Full Text Available knowledge management strategy is mentioned as one of the most important success factors for implementing knowledge management. The KM strategy selection is a complex decision that requires consideration of several factors. For evaluation and selection of an appropriate knowledge management strategy in organizations, many factors must be considered. The identified factors and their impact on knowledge management strategy are inherently ambiguous. In this study, an overview of theoretical foundations of research regarding the different knowledge management strategies has been done And factors influencing the knowledge management strategy selection have been extracted from conceptual frameworks and models. How these factors influence the knowledge management strategy selection is extracted through the fuzzy Delphi. Next a fuzzy expert system for the selection of appropriate knowledge management strategy is designed with respect to factors that have an impact on knowledge management strategy. The factors which influence the selection of knowledge management strategy include: general business strategy, organizational structure, cultural factors, IT strategy, strategic human resource management, social level, the types of knowledge creation processes and release it. The factors which influence the knowledge management strategy selection include: business strategy general, organizational structure, cultural factors, IT strategy, human resource management strategies, socialization level, knowledge types and its creation and diffusion processes. According to identified factors which affect the knowledge management strategy, the final strategy is recommended based on the range of human-oriented and system-oriented by keep the balance of explicit and implicit knowledge. The Designed system performance is tested and evaluated by the information related to three Iranian organization.

  8. Measure Guideline: Selecting Ventilation Systems for Existing Homes

    Energy Technology Data Exchange (ETDEWEB)

    Aldrich, R. [Consortium for Advanced Residential Buildings (CARB), Norwalk, CT (United States)

    2014-02-01

    This report, developed by Building America research team CARB, addresses adding or improving mechanical ventilation systems to existing homes. The goal of this report is to assist decision makers and contractors in making informed decisions when selecting ventilation systems for homes. With more air-sealed envelopes, a mechanical means of removing contaminants is critical for indoor environmental quality and building durability. The purpose of ventilation is to remove contaminants from homes, and this report discusses where, when, and how much ventilation is appropriate in a home, including examination of relevant codes and standards. Choosing the "best" system is not always straightforward; selecting a system involves balancing performance, efficiency, cost, required maintenance, and several other factors.

  9. A systematic and practical method for selecting systems engineering tools

    DEFF Research Database (Denmark)

    Munck, Allan; Madsen, Jan

    2017-01-01

    analyses of the actual needs and the available tools. Grouping needs into categories, allow us to obtain a comprehensive set of requirements for the tools. The entire model-based systems engineering discipline was categorized for a modeling tool case to enable development of a tool specification...... in successful operation since 2013 at GN Hearing. We further utilized the method to select a set of tools that we used on pilot cases at GN Hearing for modeling, simulating and formally verifying embedded systems.......The complexity of many types of systems has grown considerably over the last decades. Using appropriate systems engineering tools therefore becomes increasingly important. Starting the tool selection process can be intimidating because organizations often only have a vague idea about what they need...

  10. Synergetic aspects of gas-discharge: lateral patterns in dc systems with a high ohmic barrier

    Science.gov (United States)

    Purwins, H.-G.; Stollenwerk, L.

    2014-12-01

    The understanding of self-organized patterns in spatially extended nonlinear dissipative systems is one of the most challenging subjects in modern natural sciences. Such patterns are also referred to as dissipative structures. We review this phenomenon in planar low temperature dc gas-discharge devices with a high ohmic barrier. It is demonstrated that for these systems a deep qualitative understanding of dissipative structures can be obtained from the point of view of synergetics. At the same time, a major contribution can be made to the general understanding of dissipative structures. The discharge spaces of the experimentally investigated systems, to good approximation, have translational and rotational symmetry by contraction. Nevertheless, a given system may exhibit stable current density distributions and related patterns that break these symmetries. Among the experimentally observed fundamental patterns one finds homogeneous isotropic states, fronts, periodic patterns, labyrinth structures, rotating spirals, target patterns and localized filaments. In addition, structures are observed that have the former as elementary building blocks. Finally, defect structures as well as irregular patterns are common phenomena. Such structures have been detected in numerous other driven nonlinear dissipative systems, as there are ac gas-discharge devices, semiconductors, chemical solutions, electrical networks and biological systems. Therefore, from the experimental observations it is concluded that the patterns in planar low temperature dc gas-discharge devices exhibit universal behavior. From the theoretical point of view, dissipative structures of the aforementioned kind are also referred to as attractors. The possible sets of attractors are an important characteristic of the system. The number and/or qualitative nature of attractors may change when changing parameters. The related bifurcation behavior is a central issue of the synergetic approach chosen in the present

  11. Synergetic aspects of gas-discharge: lateral patterns in dc systems with a high ohmic barrier

    International Nuclear Information System (INIS)

    Purwins, H-G; Stollenwerk, L

    2014-01-01

    The understanding of self-organized patterns in spatially extended nonlinear dissipative systems is one of the most challenging subjects in modern natural sciences. Such patterns are also referred to as dissipative structures. We review this phenomenon in planar low temperature dc gas-discharge devices with a high ohmic barrier. It is demonstrated that for these systems a deep qualitative understanding of dissipative structures can be obtained from the point of view of synergetics. At the same time, a major contribution can be made to the general understanding of dissipative structures. The discharge spaces of the experimentally investigated systems, to good approximation, have translational and rotational symmetry by contraction. Nevertheless, a given system may exhibit stable current density distributions and related patterns that break these symmetries. Among the experimentally observed fundamental patterns one finds homogeneous isotropic states, fronts, periodic patterns, labyrinth structures, rotating spirals, target patterns and localized filaments. In addition, structures are observed that have the former as elementary building blocks. Finally, defect structures as well as irregular patterns are common phenomena. Such structures have been detected in numerous other driven nonlinear dissipative systems, as there are ac gas-discharge devices, semiconductors, chemical solutions, electrical networks and biological systems. Therefore, from the experimental observations it is concluded that the patterns in planar low temperature dc gas-discharge devices exhibit universal behavior. From the theoretical point of view, dissipative structures of the aforementioned kind are also referred to as attractors. The possible sets of attractors are an important characteristic of the system. The number and/or qualitative nature of attractors may change when changing parameters. The related bifurcation behavior is a central issue of the synergetic approach chosen in the present

  12. Knowledge based expert system approach to instrumentation selection (INSEL

    Directory of Open Access Journals (Sweden)

    S. Barai

    2004-08-01

    Full Text Available The selection of appropriate instrumentation for any structural measurement of civil engineering structure is a complex task. Recent developments in Artificial Intelligence (AI can help in an organized use of experiential knowledge available on instrumentation for laboratory and in-situ measurement. Usually, the instrumentation decision is based on the experience and judgment of experimentalists. The heuristic knowledge available for different types of measurement is domain dependent and the information is scattered in varied knowledge sources. The knowledge engineering techniques can help in capturing the experiential knowledge. This paper demonstrates a prototype knowledge based system for INstrument SELection (INSEL assistant where the experiential knowledge for various structural domains can be captured and utilized for making instrumentation decision. In particular, this Knowledge Based Expert System (KBES encodes the heuristics on measurement and demonstrates the instrument selection process with reference to steel bridges. INSEL runs on a microcomputer and uses an INSIGHT 2+ environment.

  13. Durability and CMAS Resistance of Advanced Environmental Barrier Coatings Systems for SiC/SiC Ceramic Matrix Composites

    Science.gov (United States)

    Zhu, Dongming

    2015-01-01

    Environmental barrier coatings (EBCs) and SiCSiC ceramic matrix composites (CMCs) systems will play a crucial role in next generation turbine engines for hot-section component applications because of their ability to significantly increase engine operating temperatures with improved efficiency, reduce engine weight and cooling requirements. This paper will emphasize advanced environmental barrier coating developments for SiCSiC turbine airfoil components, by using advanced coating compositions and processing, in conjunction with mechanical and environment testing and durability validations. The coating-CMC degradations and durability in the laboratory simulated engine fatigue-creep and complex operating environments are being addressed. The effects of Calcium-Magnesium-Alumino-Silicate (CMAS) from road sand or volcano-ash deposits on the degradation mechanisms of the environmental barrier coating systems will be discussed. The results help understand the advanced EBC-CMC system performance, aiming at the durability improvements of more robust, prime-reliant environmental barrier coatings for successful applications of the component technologies and lifing methodologies.

  14. System of selective disemination of information at ININ

    International Nuclear Information System (INIS)

    Martinez G, M.A.

    1981-01-01

    A study of the systems of selective dissemination of information (SDI) is presented, the concepts for such systems outlined, and their developments traced in advanced countries, its forms of operation and implications for the special libraries. Also the operation of INIS at CIDN (Centro de Informacion y Documentacion Nuclear) is presented, together with recommendations and conclusions to improve the development of this service in Mexico. (author)

  15. Expert hierarchical selection of oil and gas distribution systems

    International Nuclear Information System (INIS)

    Frankel, E.G.

    1991-01-01

    Selection and design of oil and gas distribution systems involves a large number of decision makers and interest groups, as well as many alternative technical, financial, network, operating, management and regulatory options. Their objectives and measures of performance are different. Decision models can be effectively represented by hierarchical structures. A simple deterministic analytic hierarchy process is presented with application to oil and gas distribution systems

  16. A Comparison between Human Selected, Derived and System ...

    African Journals Online (AJOL)

    admpather

    Using a prototype implementation of our scheme, we compare the results of human-selected, derived passwords and system generated to reveal the practical viability of our approach in terms of results achieved, ease of implementation and use. Keywords: Security, Biometric, Behavioral, Keystroke dynamics, Password.

  17. A Comparison between Human Selected, Derived and System ...

    African Journals Online (AJOL)

    Using a prototype implementation of our scheme, we compare the results of human-selected, derived passwords and system generated to reveal the practical viability of our approach in terms of results achieved, ease of implementation and use. Keywords: Security, Biometric, Behavioral, Keystroke dynamics, Password ...

  18. Corneal manifestations of selected systemic diseases: A review

    Directory of Open Access Journals (Sweden)

    Wayne D.H. Gillan

    2015-08-01

    Full Text Available The corneal manifestations of several selected systemic diseases are reviewed. Metabolic, immunologic and inflammatory and infectious diseases are included. A brief overview of each disease and how it manifests in the cornea is discussed. The importance of conducting a slit-lamp examination on every patient is emphasised.

  19. Online-Expert: An Expert System for Online Database Selection.

    Science.gov (United States)

    Zahir, Sajjad; Chang, Chew Lik

    1992-01-01

    Describes the design and development of a prototype expert system called ONLINE-EXPERT that helps users select online databases and vendors that meet users' needs. Search strategies are discussed; knowledge acquisition and knowledge bases are described; and the Analytic Hierarchy Process (AHP), a decision analysis technique that ranks databases,…

  20. System for illuminating a region for isotopically selective photoexcitation

    International Nuclear Information System (INIS)

    Debaryshe, P.G.; Janes, G.S.; Levy, R.H.; Lindenmeier, C.W.

    1979-01-01

    A method is described to improve laser beam utilization in isotope separation techniques (using laser induced isotopically selective photoexcitation) by increasing the probability of photon absorption without extreme beam propagation lengths. For this purpose an optical reflection system has been designed for illuminating substantially all of three-dimensional space of a transversely flowing vapor with multiple traversals of a beam of radiation. (UK)

  1. New Bond Coat Materials for Thermal Barrier Coating Systems Processed Via Different Routes

    Science.gov (United States)

    Soare, A.; Csaki, I.; Sohaciu, M.; Oprea, C.; Soare, S.; Costina, I.; Petrescu, M. I.

    2017-06-01

    This paper aims at describing the development of new Ru-based Bond Coats (BC) as part of Thermal Barrier Coatings. The challenge of this research was to obtain an adherent and uniform layer of alumina protective layer after high temperature exposure. We have prepared a RuAl 50/50 at% alloy in an induction furnace which was subsequently subjected to oxidation in an electric furnace, in air, at 1100C, for 10h and 100h. Mechanical alloying of Ru and Al powders was another processing route used in an attempt to obtain a stoichiometric RuAl. The alloy was sintered by Spark Plasma Sintering (SPS) and then oxidized at 1100C for 1 and10h. The alloys obtained as such were analysed before and after oxidation using advanced microscopy techniques (SEM and TEM). The encouraging results in case of RuAl alloys prepared by induction melting reveal that we obtained an adherent and uniform layer of alumina, free of delta-Ru. The results for the samples processed by powder metallurgy were positive but need to be further investigated. We should note here the novelty of this method for this particular type of application - as a BC part of a TBC system.

  2. Nanowired Drug Delivery Across the Blood-Brain Barrier in Central Nervous System Injury and Repair.

    Science.gov (United States)

    Sharma, Aruna; Menon, Preeti; Muresanu, Dafin F; Ozkizilcik, Asya; Tian, Z Ryan; Lafuente, José V; Sharma, Hari S

    2016-01-01

    The blood-brain barrier (BBB) is a physiological regulator of transport of essential items from blood to brain for the maintenance of homeostasis of the central nervous system (CNS) within narrow limits. The BBB is also responsible for export of harmful or metabolic products from brain to blood to keep the CNS fluid microenvironment healthy. However, noxious insults to the brain caused by trauma, ischemia or environmental/chemical toxins alter the BBB function to small as well as large molecules e.g., proteins. When proteins enter the CNS fluid microenvironment, development of brain edema occurs due to altered osmotic balance between blood and brain. On the other hand, almost all neurodegenerative diseases and traumatic insults to the CNS and subsequent BBB dysfunction lead to edema formation and cell injury. To treat these brain disorders suitable drug therapy reaching their brain targets is needed. However, due to edema formation or only a focal disruption of the BBB e.g., around brain tumors, many drugs are unable to reach their CNS targets in sufficient quantity. This results in poor therapeutic outcome. Thus, new technology such as nanodelivery is needed for drugs to reach their CNS targets and be effective. In this review, use of nanowires as a possible novel tool to enhance drug delivery into the CNS in various disease models is discussed based on our investigations. These data show that nanowired delivery of drugs may have superior neuroprotective ability to treat several CNS diseases effectively indicating their role in future therapeutic strategies.

  3. Gpr124 is essential for blood-brain barrier integrity in central nervous system disease.

    Science.gov (United States)

    Chang, Junlei; Mancuso, Michael R; Maier, Carolina; Liang, Xibin; Yuki, Kanako; Yang, Lu; Kwong, Jeffrey W; Wang, Jing; Rao, Varsha; Vallon, Mario; Kosinski, Cynthia; Zhang, J J Haijing; Mah, Amanda T; Xu, Lijun; Li, Le; Gholamin, Sharareh; Reyes, Teresa F; Li, Rui; Kuhnert, Frank; Han, Xiaoyuan; Yuan, Jenny; Chiou, Shin-Heng; Brettman, Ari D; Daly, Lauren; Corney, David C; Cheshier, Samuel H; Shortliffe, Linda D; Wu, Xiwei; Snyder, Michael; Chan, Pak; Giffard, Rona G; Chang, Howard Y; Andreasson, Katrin; Kuo, Calvin J

    2017-04-01

    Although blood-brain barrier (BBB) compromise is central to the etiology of diverse central nervous system (CNS) disorders, endothelial receptor proteins that control BBB function are poorly defined. The endothelial G-protein-coupled receptor (GPCR) Gpr124 has been reported to be required for normal forebrain angiogenesis and BBB function in mouse embryos, but the role of this receptor in adult animals is unknown. Here Gpr124 conditional knockout (CKO) in the endothelia of adult mice did not affect homeostatic BBB integrity, but resulted in BBB disruption and microvascular hemorrhage in mouse models of both ischemic stroke and glioblastoma, accompanied by reduced cerebrovascular canonical Wnt-β-catenin signaling. Constitutive activation of Wnt-β-catenin signaling fully corrected the BBB disruption and hemorrhage defects of Gpr124-CKO mice, with rescue of the endothelial gene tight junction, pericyte coverage and extracellular-matrix deficits. We thus identify Gpr124 as an endothelial GPCR specifically required for endothelial Wnt signaling and BBB integrity under pathological conditions in adult mice. This finding implicates Gpr124 as a potential therapeutic target for human CNS disorders characterized by BBB disruption.

  4. Technical basis and programmatic requirements for Engineered Barrier System Field Tests

    International Nuclear Information System (INIS)

    Lin, Wunan.

    1992-11-01

    The purpose of this study plant is to describe tests known as Engineered Barrier System Field Tests (EBSFT), which are to be conducted in the Exploratory Study Facility (ESF) at Yucca Mountain, Nevada. The EBSFT is designed to provide information on the interaction between waste packages (simulated by heated containers), the surrounding rock mass, and its vadose water. The Yucca Mountain site is being characterized to determine its suitability as a potential deep geological repository for high-level nuclear waste. Water is the main medium by which radioactive nuclides travel to the accessible environment. Therefore, the movement of water over the approximate 10,000--year lifetime required for radioactive nuclide decay must be understood. Development of a repository and emplacement of nuclear wastes impose stress loadings on the repository rock mass. The stress loadings include (1) thermal energy and irradiation from the waste packages, and (2) mechanical stress due to the mining of openings, and the transporting of waste canisters. The influence f the thermal stress may extend to all lithological units, including the saturated zone under the ground water table, in Yucca Mountain. In general, the purpose of this study is to investigate the movement of water in the rock mass under the influence of the thermal loading of the waste packages. Specifically, the study will investigate heat flow mechanism, relationship between boiling and dry-out, and the rewetting of the dry-out region when the repository is cooled down

  5. Mini-med school for Aboriginal youth: experiential science outreach to tackle systemic barriers

    Directory of Open Access Journals (Sweden)

    Rita I. Henderson

    2015-12-01

    Full Text Available Introduction: Addressing systemic barriers experienced by low-income and minority students to accessing medical school, the University of Calgary's Cumming School of Medicine has spearheaded a year-round, mini-med school outreach initiative for Aboriginal students. Method: Junior and senior high school youth generally attend the half-day program in classes or camps of 15–25, breaking into small groups for multisession activities. Undergraduate medical education students mentor the youth in stations offering experiential lessons in physical examination, reading x-rays, and anatomy. All resources from the medical school are offered in-kind, including a pizza lunch at midday, whereas community partners organize transportation for the attendees. Results: Opening the medical school and its resources to the community offers great benefits to resource-constrained schools often limited in terms of science education resources. The model is also an effort to address challenges among the medical professions around attracting and retaining students from underserved populations. Conclusion: The prospect of increasing admission rates and successful completion of medical education among students from marginalized communities poses a real, though difficult-to-measure, possibility of increasing the workforce most likely to return to and work in such challenging contexts. A mini-medical school for Aboriginal youth highlights mutual, long-term benefit for diverse partners, encouraging medical educators and community-based science educators to explore the possibilities for deepening partnerships in their own regions.

  6. The skin microbiome: impact of modern environments on skin ecology, barrier integrity, and systemic immune programming.

    Science.gov (United States)

    Prescott, Susan L; Larcombe, Danica-Lea; Logan, Alan C; West, Christina; Burks, Wesley; Caraballo, Luis; Levin, Michael; Etten, Eddie Van; Horwitz, Pierre; Kozyrskyj, Anita; Campbell, Dianne E

    2017-01-01

    Skin barrier structure and function is essential to human health. Hitherto unrecognized functions of epidermal keratinocytes show that the skin plays an important role in adapting whole-body physiology to changing environments, including the capacity to produce a wide variety of hormones, neurotransmitters and cytokine that can potentially influence whole-body states, and quite possibly, even emotions. Skin microbiota play an integral role in the maturation and homeostatic regulation of keratinocytes and host immune networks with systemic implications. As our primary interface with the external environment, the biodiversity of skin habitats is heavily influenced by the biodiversity of the ecosystems in which we reside. Thus, factors which alter the establishment and health of the skin microbiome have the potential to predispose to not only cutaneous disease, but also other inflammatory non-communicable diseases (NCDs). Indeed, disturbances of the stratum corneum have been noted in allergic diseases (eczema and food allergy), psoriasis, rosacea, acne vulgaris and with the skin aging process. The built environment, global biodiversity losses and declining nature relatedness are contributing to erosion of diversity at a micro-ecological level, including our own microbial habitats. This emphasises the importance of ecological perspectives in overcoming the factors that drive dysbiosis and the risk of inflammatory diseases across the life course.

  7. Drivers and barriers among householders to managing domestic wastewater treatment systems in the Republic of Ireland; implications for risk prevention behaviour

    Science.gov (United States)

    Devitt, Catherine; O'Neill, Eoin; Waldron, Richard

    2016-04-01

    Septic systems that are malfunctioning, improperly sited or designed, present a contamination risk to drinking water sources, and subsequently, to human health. However, the international literature identifies gaps in householder knowledge regarding the function and maintenance requirements of septic systems, and also the potential health and environmental risk implications. Allied with householder fears related to the financial cost of risk management, these factors tend to reduce concern to recognise a malfunctioning system. In the Republic of Ireland, three-quarters of households in rural areas utilise an individual domestic wastewater treatment system (or septic system). Consequently, a significant portion of rural households that rely on groundwater sources via private-well use are at risk. Ireland reports one of the highest crude incidence rates of Verotoxigenic Escherichia coli (VTEC) infection in the European Union, and waterborne transmission related to contact with untreated or poorly treated water from private water sources is a factor in its transmission. Following recent Irish legislative change that places a duty of care on individual householders to ensure a proper system functioning, this exploratory study examines perceptions towards the risk management of septic systems among Irish householders. Using qualitative research methods, four focus groups selected on the basis of geographical variation, and two semi-structured interviews were conducted. While most householders agreed that poorly maintained septic systems represented a threat to the environment and to public health, none reported to having a regular maintenance routine in place. Thematic analysis revealed the drivers and barriers to septic system maintenance, and preferences of householders pertaining to communication on septic systems. The Health Belief Model is employed to help understand results. Results suggest that householder capacity to engage in regular risk management is reduced

  8. Contribution of Sudanese medical diaspora to the healthcare delivery system in Sudan: exploring options and barriers.

    Science.gov (United States)

    Abdalla, Fayrouz Mohammed; Omar, Maye Abu; Badr, Elsheikh Elsiddig

    2016-06-30

    Medical diaspora options, including the engagement of expatriate physicians in development efforts within their home country, are being called for to reverse the effects of brain drain from developing countries. This paper presents the results of a study exploring the potential contributions for the Sudanese Medial Diaspora Options to the healthcare delivery system (HCDS) in Sudan, focusing on the options of temporal and permanent returns and the likely obstacles faced in their implementation. This was a cross-sectional study using a mixed methods design including quantitative and qualitative approaches. For the quantitative approach, the study, which focused on the possible contribution of the diaspora to healthcare delivery in Sudan, was based on an online survey using random purposive and snowballing sampling techniques involving 153 Sudanese physicians working in Saudi Arabia and other Gulf States, the United Kingdom, the Republic of Ireland, and the United States of America. The qualitative approach involved in-depth interviews with returnee physicians and key informants in Sudan, focusing on the return experiences, the barriers for return, and the options to improve future contributions. Despite contributions of the Sudanese medical diaspora being of a small scale considering the size of the phenomenon, as well as infrequent and not appropriately organized, their inputs to academia and the links built with overseas institutions and specialist clinical services were nevertheless remarkable. The main barrier to temporal return was inappropriate organization by the local counterparts, while those for permanent return of physicians were poor work environment, insufficient financial payment, unsecured accommodation, and offspring education. The study identified short-term return as a feasible option considering the country's current conditions. Proper coordination mechanisms for short-term returns and facilitation of permanent return through stakeholders

  9. An acceptability and safety study of the Duet cervical barrier and gel delivery system in Zimbabwe.

    Science.gov (United States)

    Montgomery, Elizabeth T; Woodsong, Cynthia; Musara, Petina; Cheng, Helen; Chipato, Tsungai; Moench, Thomas R; Spielberg, Freya; van der Straten, Ariane

    2010-08-05

    Adherence problems with coitally dependent, female-initiated HIV prevention methods have contributed to several trials' failure to establish efficacy. Continuous use of a cervical barrier with once-daily cleaning and immediate reinsertion may simplify use for women and improve adherence. We assessed the acceptability and safety of precoital and continuous use of the Duet, a cervical barrier and gel delivery system, in Zimbabwean women. Using a two-arm crossover design with a parallel observation group, we randomized 103 women in a 2:2:1 ratio: (1) to use the Duet continuously for 14 days, followed by a minimum of seven days of washout and then 14 days of precoital use; (2) to use the same Duet regimens in reverse order; or (3) for observation only. Women were aged 18 to 40 years; half were recruited from a pool of previous diaphragm study participants and the other half from the general community. Acceptability and adherence were assessed through an interviewer-administered questionnaire at each of two follow-up visits. Safety was monitored through pelvic speculum exams and report of adverse events. The proportion of women who reported consistent Duet use during sex was virtually identical during continuous and precoital regimens (88.6% vs. 88.9%). Partner refusal was the most common reason cited for non-use during sex in both use regimens. Not having the device handy was the most common reason cited for non-daily use (in the continuous regimen). Most women were "very comfortable" using it continuously (86.3%) and inserting it precoitally (92.8%). The most favoured Duet attribute was that it did not interfere with "natural" sex (55%). The least favoured Duet attribute was the concern that it might come out during sex (71.3%). No serious adverse events were reported during the study; 57 participants reported 90 adverse events classified as mild or moderate. There were no statistically significant differences in: (1) the proportion of women reporting adverse events

  10. Selection and implementation of a laboratory computer system.

    Science.gov (United States)

    Moritz, V A; McMaster, R; Dillon, T; Mayall, B

    1995-07-01

    The process of selection of a pathology computer system has become increasingly complex as there are an increasing number of facilities that must be provided and stringent performance requirements under heavy computing loads from both human users and machine inputs. Furthermore, the continuing advances in software and hardware technology provide more options and innovative new ways of tackling problems. These factors taken together pose a difficult and complex set of decisions and choices for the system analyst and designer. The selection process followed by the Microbiology Department at Heidelberg Repatriation Hospital included examination of existing systems, development of a functional specification followed by a formal tender process. The successful tenderer was then selected using predefined evaluation criteria. The successful tenderer was a software development company that developed and supplied a system based on a distributed network using a SUN computer as the main processor. The software was written using Informix running on the UNIX operating system. This represents one of the first microbiology systems developed using a commercial relational database and fourth generation language. The advantages of this approach are discussed.

  11. Blood-brain barrier-on-a-chip: Microphysiological systems that capture the complexity of the blood-central nervous system interface.

    Science.gov (United States)

    Phan, Duc Tt; Bender, R Hugh F; Andrejecsk, Jillian W; Sobrino, Agua; Hachey, Stephanie J; George, Steven C; Hughes, Christopher Cw

    2017-11-01

    The blood-brain barrier is a dynamic and highly organized structure that strictly regulates the molecules allowed to cross the brain vasculature into the central nervous system. The blood-brain barrier pathology has been associated with a number of central nervous system diseases, including vascular malformations, stroke/vascular dementia, Alzheimer's disease, multiple sclerosis, and various neurological tumors including glioblastoma multiforme. There is a compelling need for representative models of this critical interface. Current research relies heavily on animal models (mostly mice) or on two-dimensional (2D) in vitro models, neither of which fully capture the complexities of the human blood-brain barrier. Physiological differences between humans and mice make translation to the clinic problematic, while monolayer cultures cannot capture the inherently three-dimensional (3D) nature of the blood-brain barrier, which includes close association of the abluminal side of the endothelium with astrocyte foot-processes and pericytes. Here we discuss the central nervous system diseases associated with blood-brain barrier pathology, recent advances in the development of novel 3D blood-brain barrier -on-a-chip systems that better mimic the physiological complexity and structure of human blood-brain barrier, and provide an outlook on how these blood-brain barrier-on-a-chip systems can be used for central nervous system disease modeling. Impact statement The field of microphysiological systems is rapidly evolving as new technologies are introduced and our understanding of organ physiology develops. In this review, we focus on Blood-Brain Barrier (BBB) models, with a particular emphasis on how they relate to neurological disorders such as Alzheimer's disease, multiple sclerosis, stroke, cancer, and vascular malformations. We emphasize the importance of capturing the three-dimensional nature of the brain and the unique architecture of the BBB - something that until recently

  12. Improving energy efficiency in industrial energy systems an interdisciplinary perspective on barriers, energy audits, energy management, policies, and programs

    CERN Document Server

    Thollander, Patrik

    2012-01-01

    Industrial energy efficiency is one of the most important means of reducing the threat of increased global warming. Research however states that despite the existence of numerous technical energy efficiency measures, its deployment is hindered by the existence of various barriers to energy efficiency. The complexity of increasing energy efficiency in manufacturing industry calls for an interdisciplinary approach to the issue. Improving energy efficiency in industrial energy systems applies an interdisciplinary perspective in examining energy efficiency in industrial energy systems, and discuss

  13. Design and construction of a system for determination of Radon-222 by a surface-barrier detector

    International Nuclear Information System (INIS)

    Bonifacio M, J.; Iturbe, J.L.

    1993-01-01

    In the present work the design and construction of a system for the determination of 222 Rn is described, which utilizes silicon surface-barrier detectors. The 222 Rn gas was obtained a source of 226 Ra electrodeposited on stainless-steel discs. The well separated energies with this system makes possible the measurement and identification of alpha particles of 222 Rn, and its daughters 210 Po, 218 Po and 214 Po. (Author) 3 figs, 19 refs

  14. Effectiveness of Physical Barriers Installation for Prevention of Incidents in Mexico City’s Subway System

    OpenAIRE

    Portillo-Villasana, Gerardo de Jesús; Huerta-Barrientos, Aida; Dillarza Andrade, Yazmin

    2017-01-01

    Nowadays, suicides inside the installations of subway platforms are considered a public health problem in Mexico City. One solution to prevent them is the installation of physical barriers, but their high cost is unattractive for governmental authorities. Traditional approaches of research on the effectiveness of physical barriers for preventing suicides have been limited to analyzing statistically the effects of installing platform screen doors and blue lights on subway platforms. Although c...

  15. Reactor technology assessment and selection utilizing systems engineering approach

    Science.gov (United States)

    Zolkaffly, Muhammed Zulfakar; Han, Ki-In

    2014-02-01

    The first Nuclear power plant (NPP) deployment in a country is a complex process that needs to consider technical, economic and financial aspects along with other aspects like public acceptance. Increased interest in the deployment of new NPPs, both among newcomer countries and those with expanding programs, necessitates the selection of reactor technology among commercially available technologies. This paper reviews the Systems Decision Process (SDP) of Systems Engineering and applies it in selecting the most appropriate reactor technology for the deployment in Malaysia. The integrated qualitative and quantitative analyses employed in the SDP are explored to perform reactor technology assessment and to select the most feasible technology whose design has also to comply with the IAEA standard requirements and other relevant requirements that have been established in this study. A quick Malaysian case study result suggests that the country reside with PWR (pressurized water reactor) technologies with more detailed study to be performed in the future for the selection of the most appropriate reactor technology for Malaysia. The demonstrated technology assessment also proposes an alternative method to systematically and quantitatively select the most appropriate reactor technology.

  16. Hybrid feature selection for supporting lightweight intrusion detection systems

    Science.gov (United States)

    Song, Jianglong; Zhao, Wentao; Liu, Qiang; Wang, Xin

    2017-08-01

    Redundant and irrelevant features not only cause high resource consumption but also degrade the performance of Intrusion Detection Systems (IDS), especially when coping with big data. These features slow down the process of training and testing in network traffic classification. Therefore, a hybrid feature selection approach in combination with wrapper and filter selection is designed in this paper to build a lightweight intrusion detection system. Two main phases are involved in this method. The first phase conducts a preliminary search for an optimal subset of features, in which the chi-square feature selection is utilized. The selected set of features from the previous phase is further refined in the second phase in a wrapper manner, in which the Random Forest(RF) is used to guide the selection process and retain an optimized set of features. After that, we build an RF-based detection model and make a fair comparison with other approaches. The experimental results on NSL-KDD datasets show that our approach results are in higher detection accuracy as well as faster training and testing processes.

  17. Our Selections and Decisions: Inherent Features of the Nervous System?

    Science.gov (United States)

    Rösler, Frank

    The chapter summarizes findings on the neuronal bases of decisionmaking. Taking the phenomenon of selection it will be explained that systems built only from excitatory and inhibitory neuron (populations) have the emergent property of selecting between different alternatives. These considerations suggest that there exists a hierarchical architecture with central selection switches. However, in such a system, functions of selection and decision-making are not localized, but rather emerge from an interaction of several participating networks. These are, on the one hand, networks that process specific input and output representations and, on the other hand, networks that regulate the relative activation/inhibition of the specific input and output networks. These ideas are supported by recent empirical evidence. Moreover, other studies show that rather complex psychological variables, like subjective probability estimates, expected gains and losses, prediction errors, etc., do have biological correlates, i.e., they can be localized in time and space as activation states of neural networks and single cells. These findings suggest that selections and decisions are consequences of an architecture which, seen from a biological perspective, is fully deterministic. However, a transposition of such nomothetic functional principles into the idiographic domain, i.e., using them as elements for comprehensive 'mechanistic' explanations of individual decisions, seems not to be possible because of principle limitations. Therefore, individual decisions will remain predictable by means of probabilistic models alone.

  18. Political, policy and social barriers to health system interoperability: emerging opportunities of Web 2.0 and 3.0.

    Science.gov (United States)

    Juzwishin, Donald W M

    2009-01-01

    Achieving effective health informatics interoperability in a fragmented and uncoordinated health system is by definition not possible. Interoperability requires the simultaneous integration of health care processes and information across different types and levels of care (systems thinking). The fundamental argument of this paper is that information system interoperability will remain an unfulfilled hope until health reforms effectively address the governance (accountability), structural and process barriers to interoperability of health care delivery. The ascendency of Web 2.0 and 3.0, although still unproven, signals the opportunity to accelerate patients' access to health information and their health record. Policy suggestions for simultaneously advancing health system delivery and information system interoperability are posited.

  19. The Immune System Bridges the Gut Microbiota with Systemic Energy Homeostasis: Focus on TLRs, Mucosal Barrier, and SCFAs.

    Science.gov (United States)

    Spiljar, Martina; Merkler, Doron; Trajkovski, Mirko

    2017-01-01

    The gut microbiota is essential for the development and regulation of the immune system and the metabolism of the host. Germ-free animals have altered immunity with increased susceptibility to immunologic diseases and show metabolic alterations. Here, we focus on two of the major immune-mediated microbiota-influenced components that signal far beyond their local environment. First, the activation or suppression of the toll-like receptors (TLRs) by microbial signals can dictate the tone of the immune response, and they are implicated in regulation of the energy homeostasis. Second, we discuss the intestinal mucosal surface is an immunologic component that protects the host from pathogenic invasion, is tightly regulated with regard to its permeability and can influence the systemic energy balance. The short chain fatty acids are a group of molecules that can both modulate the intestinal barrier and escape the gut to influence systemic health. As modulators of the immune response, the microbiota-derived signals influence functions of distant organs and can change susceptibility to metabolic diseases.

  20. Technical Work Plan for: Near Field Environment: Engineered Barrier System: Radionuclide Transport Abstraction Model Report

    International Nuclear Information System (INIS)

    J.D. Schreiber

    2006-01-01

    This technical work plan (TWP) describes work activities to be performed by the Near-Field Environment Team. The objective of the work scope covered by this TWP is to generate Revision 03 of EBS Radionuclide Transport Abstraction, referred to herein as the radionuclide transport abstraction (RTA) report. The RTA report is being revised primarily to address condition reports (CRs), to address issues identified by the Independent Validation Review Team (IVRT), to address the potential impact of transport, aging, and disposal (TAD) canister design on transport models, and to ensure integration with other models that are closely associated with the RTA report and being developed or revised in other analysis/model reports in response to IVRT comments. The RTA report will be developed in accordance with the most current version of LP-SIII.10Q-BSC and will reflect current administrative procedures (LP-3.15Q-BSC, ''Managing Technical Product Inputs''; LP-SIII.2Q-BSC, ''Qualification of Unqualified Data''; etc.), and will develop related Document Input Reference System (DIRS) reports and data qualifications as applicable in accordance with prevailing procedures. The RTA report consists of three models: the engineered barrier system (EBS) flow model, the EBS transport model, and the EBS-unsaturated zone (UZ) interface model. The flux-splitting submodel in the EBS flow model will change, so the EBS flow model will be validated again. The EBS transport model and validation of the model will be substantially revised in Revision 03 of the RTA report, which is the main subject of this TWP. The EBS-UZ interface model may be changed in Revision 03 of the RTA report due to changes in the conceptualization of the UZ transport abstraction model (a particle tracker transport model based on the discrete fracture transfer function will be used instead of the dual-continuum transport model previously used). Validation of the EBS-UZ interface model will be revised to be consistent with

  1. Diffusive Transport of Sulphide through an Engineering Barrier System in a Deep Geological Repository

    Science.gov (United States)

    Briggs, S. A.; Sleep, B. E.; McKelvie, J. R. M.; Krol, M.

    2015-12-01

    Bentonite is a naturally occurring clay-rich sediment containing montmorillonite, a smectitic clay mineral that has a high cation exchange capacity and swells upon contact with water. Owing to these characteristics, highly compacted bentonite (HCB) is an often included component of engineered barrier systems (EBS) designed to protect used fuel containers (UFCs) in deep geological repositories (DGR) for high-level nuclear waste. The low water activity and high swelling pressure of HCB suppresses microbial activity and the related production of sulphide that could cause microbiologically influenced corrosion (MIC) of UFCs The Canadian Nuclear Waste Management Organization (NWMO) has chosen a UFC that consists of an inner steel core and outer copper coating which is resistant to corrosion. However, under anaerobic conditions, MIC can still contribute to UFC corrosion if sulphides are present in the groundwater. Therefore the EBS consisting of bentonite blocks and pellets has been designed to impede the movement of sulphides to the UFC. In order to examine the effectiveness of the EBS, a 3D numerical model was developed capable of simulating the diffusive transport of sulphide within the NWMO EBS. The model was developed using COMSOL Multiphysics, a finite element software package and is parametric which allows the impact of different repository layouts to be assessed. The developed model was of the entire NWMO placement room, as well as, a stand-alone UFC and included conservative assumptions such as a fully saturated system and a constant concentration boundary condition. The results showed that the highest sulphide flux occurred at the semi-spherical end caps of the UFC. Further studies examined the effect of sulphide hotspots and fractures, representing possible EBS failure mechanisms. The model results highlight that even with conservative assumptions the chosen EBS will effectively protect the UFC from microbiologically influenced corrosion.

  2. Development of a continuous motorcycle protection barrier system using computer simulation and full-scale crash testing.

    Science.gov (United States)

    Atahan, Ali O; Hiekmann, J Marten; Himpe, Jeffrey; Marra, Joseph

    2018-07-01

    Road restraint systems are designed to minimize the undesirable effects of roadside accidents and improve safety of road users. These systems are utilized at either side or median section of roads to contain and redirect errant vehicles. Although restraint systems are mainly designed against car, truck and bus impacts there is an increasing pressure by the motorcycle industry to incorporate motorcycle protection systems into these systems. In this paper development details of a new and versatile motorcycle barrier, CMPS, coupled with an existing vehicle barrier is presented. CMPS is intended to safely contain and redirect motorcyclists during a collision event. First, crash performance of CMPS design is evaluated by means of a three dimensional computer simulation program LS-DYNA. Then full-scale crash tests are used to verify the acceptability of CMPS design. Crash tests were performed at CSI proving ground facility using a motorcycle dummy in accordance with prEN 1317-8 specification. Full-scale crash test results show that CMPS is able to successfully contain and redirect dummy with minimal injury risk on the dummy. Damage on the barrier is also minimal proving the robustness of the CMPS design. Based on the test findings and further review by the authorities the implementation of CMPS was recommended at highway system. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. Optimal Subinterval Selection Approach for Power System Transient Stability Simulation

    Directory of Open Access Journals (Sweden)

    Soobae Kim

    2015-10-01

    Full Text Available Power system transient stability analysis requires an appropriate integration time step to avoid numerical instability as well as to reduce computational demands. For fast system dynamics, which vary more rapidly than what the time step covers, a fraction of the time step, called a subinterval, is used. However, the optimal value of this subinterval is not easily determined because the analysis of the system dynamics might be required. This selection is usually made from engineering experiences, and perhaps trial and error. This paper proposes an optimal subinterval selection approach for power system transient stability analysis, which is based on modal analysis using a single machine infinite bus (SMIB system. Fast system dynamics are identified with the modal analysis and the SMIB system is used focusing on fast local modes. An appropriate subinterval time step from the proposed approach can reduce computational burden and achieve accurate simulation responses as well. The performance of the proposed method is demonstrated with the GSO 37-bus system.

  4. Measurement of transepidermal water loss (TEWL) in cats with experimental skin barrier dysfunction using a closed chamber system.

    Science.gov (United States)

    Momota, Yutaka; Shimada, Kenichiro; Gin, Azusa; Matsubara, Takako; Azakami, Daigo; Ishioka, Katsumi; Nakamura, Yuka; Sako, Toshinori

    2016-10-01

    A closed chamber evaporimeter is suitable for measuring transepidermal water loss (TEWL) in cats because of the compact device size, tolerance to sudden movement and short measuring time. TEWL is a representative parameter for skin barrier dysfunction, which is one of the clinical signs of atopic dermatitis in humans and dogs. Measurement of feline TEWL has been reported, but applicability of this parameter has not been validated. The aims of this study were to determine if tape stripping is a valid experimental model in cats for studying TEWL and to determine if a closed chambered system is a suitable measurement tool for cats. Ten clinically normal cats. In order to evaluate variation of the measured values, TEWL was measured at the right and left side of the three clipped regions (axillae, lateral thigh and groin). Subsequently, TEWL was measured using sequential tape stripping of the stratum corneum as a model of acute barrier disruption. The variations between both sides of the three regions showed no significant difference. Sequential tape stripping was associated with increasing values for TEWL. Feline TEWL was shown to reflect changes in the skin barrier in an experimental model using a closed chamber system and has the potential for evaluating skin barrier function in cats with skin diseases. © 2016 ESVD and ACVD.

  5. Ocean floor sediment as a repository barrier: comparative diffusion data for selected radionuclides in sediments from the Atlantic and Pacific Oceans

    International Nuclear Information System (INIS)

    Schreiner, F.; Sabau, C.; Friedman, A.; Fried, S.

    1986-01-01

    Effective diffusion coefficients for selected radionuclides have been measured in ocean floor sediments to provide data for the assessment of barrier effectiveness in subseabed repositories for nuclear waste. The sediments tested include illite-rich and smectite-rich red clays from the mid plate gyre region of the Pacific Ocean, reducing sediment from the continental shelf of the northwest coast of North America, and Atlantic Ocean sediments from the Southern Nares Abyssal Plain and the Great Meteor East region. Results show extremely small effective diffusion coefficients with values less than 10 -14 m 2 s -1 for plutonium, americium, curium, thorium, and tin. Radionuclides with high diffusion coefficients of approximately 10 -10 m 2 s - include the anionic species pertechnetate, TcO 4 - , iodide, I - , and selenite, SO 3 -2 . Uranyl(VI) and neptunyl(V) ions, which are stable in solution, have diffusion coefficients around 10 -12 m 2 s -1 . The diffusion behavior of most radionuclides is similar in the oxygenated Pacific sediments and in the anoxic sediments from the Atlantic. An exception is neptunium, which is immobilized by Great Meteor East sediment, but has high mobility in Southern Nares Abyssal Plain sediment. Under stagnant conditions a 30 m thick sediment layer forms an effective geologic barrier isolating radionuclides in a subseabed repository from the biosphere

  6. Ocean floor sediment as a repository barrier: comparative diffusion data for selected radionuclides in sediments from the Atlantic and Pacific Oceans

    Energy Technology Data Exchange (ETDEWEB)

    Schreiner, F.; Sabau, C.; Friedman, A.; Fried, S.

    1985-01-01

    Effective diffusion coefficients for selected radionuclides have been measured in ocean floor sediments to provide data for the assessment of barrier effectiveness in subseabed repositories for nuclear waste. The sediments tested include illite-rich and smectite-rich red clays from the mid-plate gyre region of the Pacific Ocean, reducing sediment from the continental shelf of the northwest coast of North America, and Atlantic Ocean sediments from the Southern Nares Abyssal Plain and the Great Meteor East region. Results show extremely small effective diffusion coefficients with values less than 10/sup -14/ m/sup 2/s/sup -1/ for plutonium, americium, curium, thorium, and tin. Radionuclides with high diffusion coefficients of approximately 10/sup -10/ m/sup 2/s/sup -1/ include the anionic species pertechnetate, TcO/sub 4//sup -/, iodide, I/sup -/, and selenite, SeO/sub 3//sup -2/. Uranyl(VI) and neptunyl(V) ions, which are stable in solution, have diffusion coefficients around 10/sup -12/ m/sup 2/s/sup -1/. The diffusion behavior of most radionuclides is similar in the oxygenated Pacific sediments and in the anoxic sediments from the Atlantic. An exception is neptunium, which is immobilized by Great Meteor East sediment, but has high mobility in Southern Nares Abyssal Plain sediment. Under stagnant conditions a 30 m thick sediment layer forms an effective geologic barrier isolating radionuclides in a subseabed repository from the biosphere. 13 refs., 5 figs., 1 tab.

  7. Ocean floor sediment as a repository barrier: comparative diffusion data for selected radionuclides in sediments from the Atlantic and Pacific Oceans

    International Nuclear Information System (INIS)

    Schreiner, F.; Sabau, C.; Friedman, A.; Fried, S.

    1985-01-01

    Effective diffusion coefficients for selected radionuclides have been measured in ocean floor sediments to provide data for the assessment of barrier effectiveness in subseabed repositories for nuclear waste. The sediments tested include illite-rich and smectite-rich red clays from the mid-plate gyre region of the Pacific Ocean, reducing sediment from the continental shelf of the northwest coast of North America, and Atlantic Ocean sediments from the Southern Nares Abyssal Plain and the Great Meteor East region. Results show extremely small effective diffusion coefficients with values less than 10 -14 m 2 s -1 for plutonium, americium, curium, thorium, and tin. Radionuclides with high diffusion coefficients of approximately 10 -10 m 2 s -1 include the anionic species pertechnetate, TcO 4 - , iodide, I - , and selenite, SeO 3 -2 . Uranyl(VI) and neptunyl(V) ions, which are stable in solution, have diffusion coefficients around 10 -12 m 2 s -1 . The diffusion behavior of most radionuclides is similar in the oxygenated Pacific sediments and in the anoxic sediments from the Atlantic. An exception is neptunium, which is immobilized by Great Meteor East sediment, but has high mobility in Southern Nares Abyssal Plain sediment. Under stagnant conditions a 30 m thick sediment layer forms an effective geologic barrier isolating radionuclides in a subseabed repository from the biosphere. 13 refs., 5 figs., 1 tab

  8. Converse Barrier Certificate Theorems

    DEFF Research Database (Denmark)

    Wisniewski, Rafael; Sloth, Christoffer

    2016-01-01

    This paper shows that a barrier certificate exists for any safe dynamical system. Specifically, we prove converse barrier certificate theorems for a class of structurally stable dynamical systems. Other authors have developed a related result by assuming that the dynamical system has neither...

  9. Identifying Facilitators and Barriers for Patient Safety in a Medicine Label Design System Using Patient Simulation and Interviews

    DEFF Research Database (Denmark)

    Dieckmann, Peter; Clemmensen, Marianne Hald; Sørensen, Trine Kart

    2016-01-01

    Objectives Medicine label design plays an important role in improving patient safety. This study aimed at identifying facilitators and barriers in a medicine label system to prevent medication errors in clinical use by health care professionals. Methods The study design is qualitative and explora......Objectives Medicine label design plays an important role in improving patient safety. This study aimed at identifying facilitators and barriers in a medicine label system to prevent medication errors in clinical use by health care professionals. Methods The study design is qualitative...... of the system and some inconsistencies (different meaning of colors) posed challenges, when considered with the actual application context, in which there is little time to get familiar with the design features. Conclusions For optimizing medicine labels and obtaining the full benefit of label design features...

  10. Sensor Selection method for IoT systems – focusing on embedded system requirements

    Directory of Open Access Journals (Sweden)

    Hirayama Masayuki

    2016-01-01

    Full Text Available Recently, various types of sensors have been developed. Using these sensors, IoT systems have become hot topics in embedded system domain. However, sensor selections for embedded systems are not well discussed up to now. This paper focuses on embedded system’s features and architecture, and proposes a sensor selection method which is composed seven steps. In addition, we applied the proposed method to a simple example – a sensor selection for computer scored answer sheet reader unit. From this case study, an idea to use FTA in sensor selection is also discussed.

  11. A novel method to achieve selective emitter for silicon solar cell using low cost pattern-able a-Si thin films as the semi-transparent phosphorus diffusion barrier

    International Nuclear Information System (INIS)

    Chen, Da Ming; Liang, Zong Cun; Zhuang, Lin; Lin, Yang Huan; Shen, Hui

    2012-01-01

    Highlights: ► a-Si thin films as semitransparent phosphorus diffusion barriers for solar cell. ► a-Si thin films on silicon wafers were patterned by the alkaline solution. ► Selective emitter was formed with patterned a-Si as diffusion barrier for solar cell. -- Abstract: Selective emitter for silicon solar cell was realized by employing a-Si thin films as the semi-transparent diffusion barrier. The a-Si thin films with various thicknesses (∼10–40 nm) were deposited by the electron-beam evaporation technique. Emitters with sheet resistances from 37 to 145 Ω/□ were obtained via POCl 3 diffusion process. The thickness of the a-Si diffusion barrier was optimized to be 15 nm for selective emitter in our work. Homemade mask which can dissolve in ethanol was screen-printed on a-Si film to make pattern. The a-Si film was then patterned in KOH solution to form finger-like design. Selective emitter was obtainable with one-step diffusion with patterned a-Si film on. Combinations of sheet resistances for the high-/low-level doped regions of 39.8/112.1, 36.2/88.8, 35.4/73.9 were obtained. These combinations are suitable for screen-printed solar cells. This preparation method of selective emitter based on a-Si diffusion barrier is a promising approach for low cost industrial manufacturing.

  12. Decontamination systems information and research program -- Literature review in support of development of standard test protocols and barrier design models for in situ formed barriers project

    International Nuclear Information System (INIS)

    1994-12-01

    The US Department of Energy is responsible for approximately 3,000 sites in which contaminants such as carbon tetrachloride, trichlorethylene, perchlorethylene, non-volatile and soluble organic and insoluble organics (PCBs and pesticides) are encountered. In specific areas of these sites radioactive contaminants are stored in underground storage tanks which were originally designed and constructed with a 30-year projected life. Many of these tanks are now 10 years beyond the design life and failures have occurred allowing the basic liquids (ph of 8 to 9) to leak into the unconsolidated soils below. Nearly one half of the storage tanks located at the Hanford Washington Reservation are suspected of leaking and contaminating the soils beneath them. The Hanford site is located in a semi-arid climate region with rainfall of less than 6 inches annually, and studies have indicated that very little of this water finds its way to the groundwater to move the water down gradient toward the Columbia River. This provides the government with time to develop a barrier system to prevent further contamination of the groundwater, and to develop and test remediation systems to stabilize or remove the contaminant materials. In parallel to remediation efforts, confinement and containment technologies are needed to retard or prevent the advancement of contamination plumes through the environment until the implementation of remediation technology efforts are completed. This project examines the various confinement and containment technologies and protocols for testing the materials in relation to their function in-situ

  13. Machine-Vision Systems Selection for Agricultural Vehicles: A Guide

    Directory of Open Access Journals (Sweden)

    Gonzalo Pajares

    2016-11-01

    Full Text Available Machine vision systems are becoming increasingly common onboard agricultural vehicles (autonomous and non-autonomous for different tasks. This paper provides guidelines for selecting machine-vision systems for optimum performance, considering the adverse conditions on these outdoor environments with high variability on the illumination, irregular terrain conditions or different plant growth states, among others. In this regard, three main topics have been conveniently addressed for the best selection: (a spectral bands (visible and infrared; (b imaging sensors and optical systems (including intrinsic parameters and (c geometric visual system arrangement (considering extrinsic parameters and stereovision systems. A general overview, with detailed description and technical support, is provided for each topic with illustrative examples focused on specific applications in agriculture, although they could be applied in different contexts other than agricultural. A case study is provided as a result of research in the RHEA (Robot Fleets for Highly Effective Agriculture and Forestry Management project for effective weed control in maize fields (wide-rows crops, funded by the European Union, where the machine vision system onboard the autonomous vehicles was the most important part of the full perception system, where machine vision was the most relevant. Details and results about crop row detection, weed patches identification, autonomous vehicle guidance and obstacle detection are provided together with a review of methods and approaches on these topics.

  14. Corrosion behaviour of materials selected for FMIT lithium system

    Energy Technology Data Exchange (ETDEWEB)

    Bazinet, G.D.; Brehm, W.F.

    1983-09-01

    The corrosion behavior of selected materials in a liquid lithium environment was studied in support of system and component designs for the Fusion Materials Irradiation Test (FMIT) Facility. Testing conditions ranged from about 3700 to about6500 hours of exposure to flowing lithium at temperatures from 230/sup 0/ to 270/sup 0/C and static lithium at temperatures from 200/sup 0/ to 500/sup 0/C. Principal areas of investigation included lithium corrosion/erosion effects on FMIT lithium system baseline and candidate materials. Material coupons and full-size prototypic components were evaluated to determine corrosion rates, fatigue crack growth rates, structural compatibility, and component acceptability for the lithium system. Based on the results of these studies, concerns regarding system materials and component designs were satisfactorily resolved to support a 20-year design life requirement for the FMIT lithium system.

  15. Corrosion behaviour of materials selected for FMIT lithium system

    International Nuclear Information System (INIS)

    Bazinet, G.D.; Brehm, W.F.

    1983-01-01

    The corrosion behavior of selected materials in a liquid lithium environment was studied in support of system and component designs for the Fusion Materials Irradiation Test (FMIT) Facility. Testing conditions ranged from about 3700 to about6500 hours of exposure to flowing lithium at temperatures from 230 0 to 270 0 C and static lithium at temperatures from 200 0 to 500 0 C. Principal areas of investigation included lithium corrosion/erosion effects on FMIT lithium system baseline and candidate materials. Material coupons and full-size prototypic components were evaluated to determine corrosion rates, fatigue crack growth rates, structural compatibility, and component acceptability for the lithium system. Based on the results of these studies, concerns regarding system materials and component designs were satisfactorily resolved to support a 20-year design life requirement for the FMIT lithium system

  16. Engineered Barrier System - Long-term Stability of Buffer and Backfill. Synthesis and extended abstracts

    Energy Technology Data Exchange (ETDEWEB)

    Apted, Mick; Arthur, Randy [Monitor Scientific LLC, Denver, CO (United States); Savage, Dave [Quintessa Ltd., Nottingham (GB)] (eds.)

    2005-09-15

    SKI is preparing to review the license applications being developed by the Swedish Nuclear Fuel and Waste Management Company (SKB) for an encapsulation plant and a deep repository for the geological disposal of spent nuclear fuel. As part of its preparation, SKI is conducting a series of technical workshops on key aspects of the Engineered Barrier System (EBS) of the repository. This workshop concerns the longterm stability of the buffer and the backfill. Previous workshops have addressed the overall concept for long-term integrity of the EBS, the manufacturing, testing and QA of the EBS and the performance confirmation for the EBS. The goal of this work is to achieve a comprehensive overview of all aspects of SKB's EBS work prior to the handling of forthcoming license applications. The reports from the EBS workshops will be used as one important basis in future review work. The workshops involve the gathering of a sufficient number of independent experts in different subjects of relevance to the particular aspect of EBS. A workshop starts with presentations and discussions among these experts. Following this, SKB presents recent results and responds to questions as part of an informal hearing. Finally, the independent experts and the SKI staff examine the SKB responses from different viewpoints. This report aims to summarise the issues discussed at the buffer and backfill workshop and to extract the essential viewpoints that have been expressed. The report is not a comprehensive record of the discussions and individual statements made by workshop participants should be regarded as opinions rather than proven facts. This reports includes apart from the workshop synthesis, questions to SKB identified prior or during the workshop, and extended abstracts for introductory presentations.

  17. Engineered Barrier System - Long-term Stability of Buffer and Backfill. Synthesis and extended abstracts

    International Nuclear Information System (INIS)

    Apted, Mick; Arthur, Randy; Savage, Dave

    2005-09-01

    SKI is preparing to review the license applications being developed by the Swedish Nuclear Fuel and Waste Management Company (SKB) for an encapsulation plant and a deep repository for the geological disposal of spent nuclear fuel. As part of its preparation, SKI is conducting a series of technical workshops on key aspects of the Engineered Barrier System (EBS) of the repository. This workshop concerns the longterm stability of the buffer and the backfill. Previous workshops have addressed the overall concept for long-term integrity of the EBS, the manufacturing, testing and QA of the EBS and the performance confirmation for the EBS. The goal of this work is to achieve a comprehensive overview of all aspects of SKB's EBS work prior to the handling of forthcoming license applications. The reports from the EBS workshops will be used as one important basis in future review work. The workshops involve the gathering of a sufficient number of independent experts in different subjects of relevance to the particular aspect of EBS. A workshop starts with presentations and discussions among these experts. Following this, SKB presents recent results and responds to questions as part of an informal hearing. Finally, the independent experts and the SKI staff examine the SKB responses from different viewpoints. This report aims to summarise the issues discussed at the buffer and backfill workshop and to extract the essential viewpoints that have been expressed. The report is not a comprehensive record of the discussions and individual statements made by workshop participants should be regarded as opinions rather than proven facts. This reports includes apart from the workshop synthesis, questions to SKB identified prior or during the workshop, and extended abstracts for introductory presentations

  18. Experimental Studies of Engineered Barrier Systems Conducted at Los Alamos National Laboratory (FY16)

    Energy Technology Data Exchange (ETDEWEB)

    Caporuscio, Florie Andre [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Norskog, Katherine Elizabeth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Maner, James [Univ. of Oklahoma, Norman, OK (United States). School of Geology and Geophysics; Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Palaich, Sarah [Univ. of California, Los Angeles, CA (United States). Dept. of Earth, Planetary, and Space Sciences; Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Cheshire, Michael C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-08-04

    Over the past five years the Used Fuel Campaign has investigated Engineered Barrier Systems (EBS) at higher heat loads (up to 300°C) and pressure (150 bar). This past year experimental work was hindered due to a revamping of the hydrothermal lab. Regardless, two experiments were run this past year, EBS-18 and EBS-19. EBS-18 was run using Low Carbon Steel (LCS) and opalinus clay in addition to the bentonite and opalinus brine. Many of the past results were confirmed in EBS-18, such as the restriction of illite formation due to the bulk chemistry, pyrite degradation, and zeolite formation dependent on the bentonite and opalinus clay. The LCS show vast amounts of pit corrosion (over 100μm of corrosion in six weeks), leading a corrosion rate of 1083 μm/year. In addition, a mineral goethite, an iron-bearing hydroxide, formed in the pits of the LCS. Preliminary results from EBS-19 water chemistry are included but SEM imaging, micro probe and XRD are still needed for further results. Copper corrosion was investigated further and over 850 measurements were taken. It was concluded that pitting and pyrite degradation drastically increase the corrosion rate from 0.12 to 0.39 μm/day. However, the growth of a layer of the mineral chalcocite is thought to subdue the corrosion rate to 0.024 μm/day as observed in the EBS-13, a sixth month experiment. This document presents the findings of this past year.

  19. Quality assurance considerations for nuclear power system selection

    International Nuclear Information System (INIS)

    Bender, M.

    1977-01-01

    The key quality assurance principle to be applied in nuclear system selection is to establish that the technological basis is understood and used properly. Knowledgeable and capable personnel with experience in the application are needed, and they must have access to appropriate engineering, laboratory, and manufacturing facilities. A suitable balance must be maintained between the responsibilities of the seller-supplier and the purchaser-owner to assure an even-handed treatment of the implementation program. Safety and reliability must be inherent to the regulatory framework. There must be flexibility in the purchaser-owner resources to overcome unanticipated adversity. Given these quality assurance elements, the nuclear system selection process should result in a high probability that the performance objectives will be satisfied

  20. Design of an operations manager selection system in service encounter

    Directory of Open Access Journals (Sweden)

    Tanawin Nunthaphanich

    2015-10-01

    Full Text Available The purpose of this study is to provide criteria for selecting operations managers at the ‘service encounter’ for mobile telecommunication companies, and develop a system for this multi-criteria decision-making scheme based on the Analytical Hierarchy Process (AHP. There are three main criteria for evaluating the capability of service-encounter operation managers: (1 the ability to design service process; (2 the ability to operate service process; (3 the ability to conduct improvement. The AHP operation manager selection tool was developed based on the complex problems at the service encounter. It was created as a decision support system which was used to recruit and evaluate operations managers’ capability for the purpose of career advancement.

  1. Fission Meter Information Barrier Attribute Measurement System - NA-243 FNI/UKC FY2017 Task 1-2 Report

    Energy Technology Data Exchange (ETDEWEB)

    Kerr, P. L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Decman, D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Prasad, M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Castro, P. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2018-01-03

    An SNM attribute Information Barrier (IB) system was developed for a 2011 US/UK Exercise. The system was modified and extensively tested in a 2013-2014 US-UK Measurement Campaign. This work demonstrated rapid deployment of an IB system for potential treaty use. The system utilizes an Ortec Fission Meter neutron multiplicity counter and custom computer code. The system demonstrates a proof-of-principle automated Pu-240 mass determination with an information barrier. After a software start command is issued, the system automatically acquires and downloads data, performs an analysis, and displays the results. This system conveys the results of a Pu mass threshold measurements in a way the does not reveal sensitive information. In full IB mode, only the pass/fail result is displayed as a “Mass <= Threshold Amount” or “Mass >= Threshold Amount” as shown in Figure 4. This can easily be adapted to a red/green “lights” display similar to the Detective IB system for Pu isotopics as shown in Figure 6. In test mode, more detailed information is displayed. The code can also read in, analyze, and display results from previously acquired or simulated data. Because the equipment is commercial-off-the-shelf (COTS), the system demonstrates a low-cost short-lead-time technology for treaty SNM attribute measurements. A deployed system will likely require integration of additional authentication and tamper-indicating technologies. This will be discussed for the project in this and future progress reports.

  2. Functionally gradient materials for thermal barrier coatings in advanced gas turbine systems

    Energy Technology Data Exchange (ETDEWEB)

    Banovic, S.W.; Barmak, K.; Chan, H.M. [Lehigh Univ., Bethlehem, PA (United States)] [and others

    1995-10-01

    New designs for advanced gas turbine engines for power production are required to have higher operating temperatures in order to increase efficiency. However, elevated temperatures will increase the magnitude and severity of environmental degradation of critical turbine components (e.g. combustor parts, turbine blades, etc{hor_ellipsis}). To offset this problem, the usage of thermal barrier coatings (TBCs) has become popular by allowing an increase in maximum inlet temperatures for an operating engine. Although thermal barrier technology is over thirty years old, the principle failure mechanism is the spallation of the ceramic coating at or near the ceramic/bond coat interface. Therefore, it is desirable to develop a coating that combines the thermal barrier qualities of the ceramic layer and the corrosion protection by the metallic bond coat without the detrimental effects associated with the localization of the ceramic/metal interface to a single plane.

  3. Facilitators and barriers to doing workplace mental health research: Case study of acute psychological trauma in a public transit system.

    Science.gov (United States)

    Links, Paul S; Bender, Ash; Eynan, Rahel; O'Grady, John; Shah, Ravi

    2016-03-10

    The Acute Psychological Trauma (APT) Study was a collaboration between an acute care hospital, a specialized multidisciplinary program designed to meet the mental health needs of injured workers, and a large urban public transit system. The overall purpose was to evaluate a Best Practices Intervention (BPI) for employees affected by acute psychological trauma compared to a Treatment as Usual (TAU) group. The specific purpose is to discuss facilitators and barriers that were recognized in implementing and carrying out mental health research in a workplace setting. Over the course of the APT study, a joint implementation committee was responsible for day-to-day study operations and made regular observations on the facilitators and barriers that arose throughout the study. The facilitators to this study included the longstanding relationships among the partners, increased recognition for the need of mental health research in the workplace, and the existence of a community advisory committee. The significant barriers to doing this study of mental health research in the workplace included differences in organizational culture, inconsistent union support, co-interventions, and stigma. Researchers and funding agencies need to be flexible and provide additional resources in order to overcome the barriers that can exist doing workplace mental health research.

  4. Coupled channel effects in quasi-elastic barrier distributions of 16,18O + 206Pb systems

    International Nuclear Information System (INIS)

    Jha, V.; Roy, B.J.; Parkar, V.V.; Kumawat, H.; Pal, U.K.; Pandit, S.K.; Mahata, K.; Shrivastava, A.; Mohanty, A.K.

    2013-01-01

    The fusion barrier distribution and QEBD for the 16 O + 208 Pb have been studied in great detail. The couplings due to the collective excitations of the colliding nuclei are found to have the dominant effect as deduced by the conventional coupled-channels calculations used to explain the experimental QEBD and fusion barrier distributions. In contrast, for the 18 O + 206 Pb system, the role of single neutron stripping (Q-value= -1.308 MeV) and neutron pair transfer (Q-value = + 1.917 MeV) are expected to be significant. In the present work, the QEBD measurements for the 18 O + 206 Pb system are performed for the investigation of these aspects

  5. Decision Analysis System for Selection of Appropriate Decontamination Technologies

    International Nuclear Information System (INIS)

    Ebadian, M.A.; Boudreaux, J.F.; Chinta, S.; Zanakis, S.H.

    1998-01-01

    The principal objective for designing Decision Analysis System for Decontamination (DASD) is to support DOE-EM's endeavor to employ the most efficient and effective technologies for treating radiologically contaminated surfaces while minimizing personnel and environmental risks. DASD will provide a tool for environmental decision makers to improve the quality, consistency, and efficacy of their technology selection decisions. The system will facilitate methodical comparisons between innovative and baseline decontamination technologies and aid in identifying the most suitable technologies for performing surface decontamination at DOE environmental restoration sites

  6. Environmental and economical aspects of selected energy system

    International Nuclear Information System (INIS)

    1991-11-01

    An analysis of environmental and economical aspects of selected renewable energy systems is presented. The aim was to provide a basis for estimating the competitive status in each case, to review the consequences of technological development, to identify attractive markets and to evaluate the effects of various economic conditions. Calculation methods are described and individual solar heating systems are compared to oil-fired boilers, boilers fired with solid fuels are compared to oil-fired boilers and straw-fired cogeneration plants are compared with coal, fuel-oil and straw-fired district heating plants. Results are presented in the form of tables and graphs. (AB)

  7. The Development of Environmental Barrier Coating Systems for SiC-SiC Ceramic Matrix Composites: Environment Effects on the Creep and Fatigue Resistance

    Science.gov (United States)

    Zhu, Dongming; Ghosn, Louis J.

    2014-01-01

    Topics covered include: Environmental barrier coating system development: needs, challenges and limitations; Advanced environmental barrier coating systems (EBCs) for CMC airfoils and combustors; NASA EBC systems and material system evolutions, Current turbine and combustor EBC coating emphases, Advanced development, processing, testing and modeling, EBC and EBC bond coats: recent advances; Design tool and life prediction of coated CMC components; Advanced CMC-EBC rig demonstrations; Summary and future directions.

  8. Modelling Coupled Processes in the Evolution of Repository Engineered Barrier Systems using QPAC-EBS

    Energy Technology Data Exchange (ETDEWEB)

    Maul, Philip; Benbow, Steven; Bond, Alex; Robinson, Peter (Quintessa Limited, Henley-on-Thames (United Kingdom))

    2010-08-15

    A satisfactory understanding of the evolution of repository engineered barrier systems (EBS) is an essential part of the safety case for the repository. This involves consideration of coupled Thermal (T), Hydro (H), Mechanical (M) and Chemical (C) processes. Quintessa's general-purpose modelling code QPAC is capable of representing strongly coupled non-linear processes and has been used in a wide range of applications. This code is the basis for software used by Quintessa in studies of the evolution of the EBS in a deep repository for spent nuclear fuel undertaken for SKI and then SSM since 2007. The collection of software components employed has been referred to collectively as QPAC-EBS, consisting of the core QPAC code together with relevant modules for T, H, M and C processes. QPAC-EBS employs a fundamentally different approach from dedicated codes that model such processes (although few codes can represent each type of process), enabling the specification of new processes and the associated governing equations in code input. Studies undertaken to date have demonstrated that QPAC-EBS can be used effectively to investigate both the early evolution of the EBS and important scenarios for the later evolution of the system when buffer erosion and canister corrosion may occur. A key issue for modelling EBS evolution is the satisfactory modelling of the behaviour of the bentonite buffer. Bentonite is a difficult material to model, partly because of the complex coupled mechanical, hydro and chemical processes involved in swelling during resaturation. Models employed to date have generally taken an empirical approach, but a new model developed during the EU THERESA project could be further developed to provide a better representation of these processes. QPAC-EBS could play an important role in supporting SSM.s review of the forthcoming SR-Site assessment by SKB if used by Quintessa in independent supporting calculations. To date radionuclide transport calculations

  9. Seismic evidence for the preservation of several stacked Pleistocene coastal barrier/lagoon systems on the Gulf of Valencia continental shelf (western Mediterranean)

    Science.gov (United States)

    Albarracín, Silvia; Alcántara-Carrió, Javier; Barranco, Andrés; Sánchez García, María José; Fontán Bouzas, Ángela; Rey Salgado, Jorge

    2013-04-01

    The focus of this study is the analysis of coastal sand barriers and associated coastal lagoons on the inner continental shelf of the Gulf of Valencia (western Mediterranean), based on two W-E seismic profiles recorded seaward of the Albufera de Valencia coastal lagoon. Seismic facies identified include a number of coastal sand barriers with landward lagoons draped by contemporary continental shelf deposits. The barrier systems have been grouped into two sedimentary systems tracts, the older one corresponding to a prograding/aggrading highstand systems tract involving at least four paleo-coastal sand barrier/lagoon systems, followed landward by a transgressive systems tract comprising three such systems. All the systems have been allocated a Tyrrhenian age, the formation of individual barrier systems having been associated with successive sea-level stillstands, and their present-day position being explained by the very high regional subsidence rate. In summary, this study demonstrates that the Quaternary stratigraphic record of the Gulf of Valencia inner continental shelf is composed of littoral sand facies, in particular coastal sand barrier and lagoon deposits. These findings are in agreement with corresponding observations on other continental shelves of the western Mediterranean, showing that the formation of coastal sand barriers was a characteristic feature of this region during the Quaternary.

  10. Cultural selection drives the evolution of human communication systems.

    Science.gov (United States)

    Tamariz, Monica; Ellison, T Mark; Barr, Dale J; Fay, Nicolas

    2014-08-07

    Human communication systems evolve culturally, but the evolutionary mechanisms that drive this evolution are not well understood. Against a baseline that communication variants spread in a population following neutral evolutionary dynamics (also known as drift models), we tested the role of two cultural selection models: coordination- and content-biased. We constructed a parametrized mixed probabilistic model of the spread of communicative variants in four 8-person laboratory micro-societies engaged in a simple communication game. We found that selectionist models, working in combination, explain the majority of the empirical data. The best-fitting parameter setting includes an egocentric bias and a content bias, suggesting that participants retained their own previously used communicative variants unless they encountered a superior (content-biased) variant, in which case it was adopted. This novel pattern of results suggests that (i) a theory of the cultural evolution of human communication systems must integrate selectionist models and (ii) human communication systems are functionally adaptive complex systems.

  11. Functional Analysis Of A Selected Airport’s System

    Directory of Open Access Journals (Sweden)

    Dudek Ewa

    2015-11-01

    Full Text Available In this paper two selected airport’s systems (Flight Information System and Public Address Voice Annunciation are defined and described. Then they are used to create an integrated unit, with the presentation of its way of functioning and a schematic picture. The author names main purposes of the integration process, serving to counteract negative consequences arising from implementation of the increasing number of systems on transport objects. In the following part of the article functional analysis of the integrated unit is carried out, defining system’s possible states of work and relations between them. Utilization of mathematical apparatus allows to calculate probabilities of system staying in the respective states, as well as system’s time indexes. Presented results are a fundament for the further analysis of this matter.

  12. Waste package/engineered barrier system design concepts for the direct disposal of spent fuel in the potential United States' repository at Yucca Mountain, Nevada

    International Nuclear Information System (INIS)

    Stahl, D.; Harrison, D.J.

    1993-01-01

    The goal of the US Department of Energy's (DOE) Yucca Mountain Site Characterization Project (YMP) waste package development program is to design a waste package and associated engineered barrier system (EBS) that meets the applicable regulatory requirements for safe disposal of spent nuclear fuel and solidified high-level waste (HLW) in a geologic repository. Attainment of this goal relies on a multi-barrier approach, the unsaturated nature of the Yucca Mountain site, consideration of technical alternatives, and sufficient resolution of technical and regulatory uncertainties. To accomplish this, an iterative system engineering approach will be used. The NWPA of 1982 limits the content of the first US repository to 70,000 metric tons of heavy metal (MTHM). The DOE Mission Plan describes the implementation of the provisions of the NWPA for the waste management system. The Draft 1988 approach will involve selecting candidate designs, evaluating them against performance requirements, and then selecting one or two preferred designs for further detailed evaluation and final design. The reference design of the waste package described in the YMP Site Characterization Plan is a thin-walled, vertical borehole-emplaced waste package with an air gap between the package and the rock wall. The reference design appeared to meet the design requirement. However, the degree of uncertainty was large. This uncertainty led to considering several more-robust design concepts during the Advanced Conceptual Design phase of the program that include small, drift-emplaced packages and higher capacity, drift-emplaced packages, both partially and totally self-shielded. Metallic as well as ceramic materials are being considered

  13. Financing Solar Energy Systems with Energy Savings Performance Contracts in the Federal Sector: Results of a Survey on Barriers

    Energy Technology Data Exchange (ETDEWEB)

    Gee, R. C.; LaPorta, C.

    1999-08-17

    This report summarizes the findings of an investigation into financing solar energy systems for the Federal sector. The objectives of the investigation were (1) to identify the barriers that impede companies from using Energy Savings Performance Contracts (ESPCs) to develop solar energy projects for Federal facilities, and (2) to clarify the impacts of Federal contracting requirements on energy service companies' use of ESPCs. Twenty-four representatives of energy service companies agreed to be interviewed. Their responses indicate that these are the primary barriers to greater use of ESPCs: the relatively long payback periods for investments in solar technologies; the length of the ESPC process; the cost of certain contractual requirements regarding wages and financing; and a lack of knowledge about the actual cost and reliability of solar systems. The report proposes a number of actions the government could take to remove these barriers, including (1) streamlining and shortening the ESPC process and (2) doing more to inform both government agencies and energy service companies about the costs and benefits of solar systems.

  14. Why are IPTp coverage targets so elusive in sub-Saharan Africa? A systematic review of health system barriers.

    Science.gov (United States)

    Thiam, Sylla; Kimotho, Victoria; Gatonga, Patrick

    2013-10-03

    Use of intermittent preventive treatment (IPTp) is a proven cost-effective intervention for preventing malaria in pregnancy. However, despite the roll-out of IPTp policies across Africa more than ten years ago, utilization levels remain low. This review sought to consolidate scattered evidence as to the health system barriers for IPTp coverage in the continent. Relevant literature from Africa was systematically searched, reviewed and synthesized. Only studies containing primary data were considered. Studies reveal that: (i) poor leadership and governance contribute to slow decentralization of programme management, lack of harmonized guidelines, poor accountability mechanisms, such as robust monitoring and evaluation systems; (ii) low budgetary allocation towards policy implementation slows scale-up, while out-of-pocket expenditure deters women from seeking antenatal services that include IPTp; (iii) there are rampant human resource challenges including low staff motivation levels attributed to such factors as incorrect knowledge of IPTp recommendations and inadequate staffing; (iv) implementation of IPTp policies is hampered by prevailing service delivery barriers, such as long waiting time, long distances to health facilities and poor service provider/client relations; and (v) drug stock-outs and poor management of information and supply chains impair sustained availability of drugs for IPTp. For successful IPTp policy implementation, it is imperative that malaria control programmes target health system barriers that result in low coverage and hence programme ineffectiveness.

  15. Attitude towards the incorporation of the selective collection of biowaste in a municipal solid waste management system. A case study

    International Nuclear Information System (INIS)

    Bernad-Beltrán, D.; Simó, A.; Bovea, M.D.

    2014-01-01

    Highlights: • Attitude towards incorporating biowaste selective collection is analysed. • Willingness to participate and to pay in biowaste selective collection is obtained. • Socioeconomic aspects affecting WtParticipate and WtPay are identified. - Abstract: European waste legislation has been encouraging for years the incorporation of selective collection systems for the biowaste fraction. European countries are therefore incorporating it into their current municipal solid waste management (MSWM) systems. However, this incorporation involves changes in the current waste management habits of households. In this paper, the attitude of the public towards the incorporation of selective collection of biowaste into an existing MSWM system in a Spanish municipality is analysed. A semi-structured telephone interview was used to obtain information regarding aspects such as: level of participation in current waste collection systems, willingness to participate in selective collection of biowaste, reasons and barriers that affect participation, willingness to pay for the incorporation of the selective collection of biowaste and the socioeconomic characteristics of citizens who are willing to participate and pay for selective collection of biowaste. The results showed that approximately 81% of the respondents were willing to participate in selective collection of biowaste. This percentage would increase until 89% if the Town Council provided specific waste bins and bags, since the main barrier to participate in the new selective collection system is the need to use specific waste bin and bags for the separation of biowaste. A logit response model was applied to estimate the average willingness to pay, obtaining an estimated mean of 7.5% on top of the current waste management annual tax. The relationship of willingness to participate and willingness to pay for the implementation of this new selective collection with the socioeconomic variables (age, gender, size of the

  16. Attitude towards the incorporation of the selective collection of biowaste in a municipal solid waste management system. A case study

    Energy Technology Data Exchange (ETDEWEB)

    Bernad-Beltrán, D. [Department of Mechanical Engineering and Construction, Universitat Jaume I, Av Sos Baynat s/n, E12071 Castellón (Spain); Simó, A. [Department of Mathematics, Universitat Jaume I, Av Sos Baynat s/n, E12071 Castellón (Spain); Bovea, M.D., E-mail: bovea@uji.es [Department of Mechanical Engineering and Construction, Universitat Jaume I, Av Sos Baynat s/n, E12071 Castellón (Spain)

    2014-12-15

    Highlights: • Attitude towards incorporating biowaste selective collection is analysed. • Willingness to participate and to pay in biowaste selective collection is obtained. • Socioeconomic aspects affecting WtParticipate and WtPay are identified. - Abstract: European waste legislation has been encouraging for years the incorporation of selective collection systems for the biowaste fraction. European countries are therefore incorporating it into their current municipal solid waste management (MSWM) systems. However, this incorporation involves changes in the current waste management habits of households. In this paper, the attitude of the public towards the incorporation of selective collection of biowaste into an existing MSWM system in a Spanish municipality is analysed. A semi-structured telephone interview was used to obtain information regarding aspects such as: level of participation in current waste collection systems, willingness to participate in selective collection of biowaste, reasons and barriers that affect participation, willingness to pay for the incorporation of the selective collection of biowaste and the socioeconomic characteristics of citizens who are willing to participate and pay for selective collection of biowaste. The results showed that approximately 81% of the respondents were willing to participate in selective collection of biowaste. This percentage would increase until 89% if the Town Council provided specific waste bins and bags, since the main barrier to participate in the new selective collection system is the need to use specific waste bin and bags for the separation of biowaste. A logit response model was applied to estimate the average willingness to pay, obtaining an estimated mean of 7.5% on top of the current waste management annual tax. The relationship of willingness to participate and willingness to pay for the implementation of this new selective collection with the socioeconomic variables (age, gender, size of the

  17. BiOSS: A system for biomedical ontology selection.

    Science.gov (United States)

    Martínez-Romero, Marcos; Vázquez-Naya, José M; Pereira, Javier; Pazos, Alejandro

    2014-04-01

    In biomedical informatics, ontologies are considered a key technology for annotating, retrieving and sharing the huge volume of publicly available data. Due to the increasing amount, complexity and variety of existing biomedical ontologies, choosing the ones to be used in a semantic annotation problem or to design a specific application is a difficult task. As a consequence, the design of approaches and tools addressed to facilitate the selection of biomedical ontologies is becoming a priority. In this paper we present BiOSS, a novel system for the selection of biomedical ontologies. BiOSS evaluates the adequacy of an ontology to a given domain according to three different criteria: (1) the extent to which the ontology covers the domain; (2) the semantic richness of the ontology in the domain; (3) the popularity of the ontology in the biomedical community. BiOSS has been applied to 5 representative problems of ontology selection. It also has been compared to existing methods and tools. Results are promising and show the usefulness of BiOSS to solve real-world ontology selection problems. BiOSS is openly available both as a web tool and a web service. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  18. Resource evaluation and site selection for microalgae production systems

    Energy Technology Data Exchange (ETDEWEB)

    Maxwell, E.L.; Folger, A.G.; Hogg, S.E.

    1985-05-01

    Climate, land, and water resource requirements of microalgae production systems (MPS) were examined relative to construction costs, operating costs, and biomass productivity. The objective was the stratification of the southwestern United States into zones of relative suitability for MPS. Maps of climate (insolation, freeze-free period, precipitation, evaporation, thunderstorm days), land (use/cover, ownership, slope), and water (saline groundwater) resource parameters were obtained. These maps were transformed into digital overlays permitting the cell-by-cell compositing of selected resource parameters to form maps representing relative productivity, make-up water, climate suitability, land suitability, water suitability, and overall suitability. The Southwest was selected for this study because of its high levels of insolation, saline water resources, and large areas of relatively low valued land. The stratification maps cannot be used for the selection of specific sites because of their low resolution (12,455-acre cells). They can be used to guide future resource studies and site selection efforts, however, by limiting these efforts to the most suitable regions. Future efforts should concentrate on saline water resources, for which only limited data are currently available. 13 refs., 44 figs., 5 tabs.

  19. No runoff, no soil loss : soil and water conservation in hedgerow barrier systems

    NARCIS (Netherlands)

    Kiepe, P.

    1995-01-01

    Land degradation by water erosion represents a serious, and fast increasing, environmental threat. Hedgerow barriers control water erosion through the presence of the tree stem and through an increase in infiltration beneath the hedgerow. The infiltration rate beneath hedgerows is 3-8 times

  20. Quantifying system safety: A comparison of the SBOAT & Safety Barrier Manager tools

    DEFF Research Database (Denmark)

    Hansen, Zaza Nadja Lee; Duijm, Nijs Jan; Markert, Frank

    2015-01-01

    This paper presents two software tools for analyzing safety risks, SBOAT (Stochastic BPMN Optimisation and Analysis Tool) and SBM (SafetyBarrierManagerr). SBOAT employs principles from stochastic model checking to allow for the quantitative verification of workflows. SBM supports the creation...

  1. Systems pharmacology and blood-brain barrier functionality in Parkinson's disease

    NARCIS (Netherlands)

    Ravenstijn, Paulien Gerarda Maria

    2009-01-01

    Parkinson’s disease is a progressive neurodegenerative disease, which is composed of many components, each caused by interplay of a number of genetic and nongenetic causes. As the blood-brain barrier (BBB) is a key player in the relationship between plasma and brain pharmacokinetics, the influences

  2. Institutional and structural barriers for implementing on-farm water saving irrigation systems

    DEFF Research Database (Denmark)

    Pedersen, Søren Marcus; Boesen, Mads Vejlby; Ørum, Jens Erik

    2013-01-01

    institutional and structural barriers for shifting to more water efficient technologies on farms. To deal with the lack of incentives, a holistic and multidisciplinary assessment approach has been taken to cover the various parameters that may influence farmers' choice of technology. A case study analysis has...

  3. Elastic scattering study of three 4n nuclei systems above the Coulomb barrier

    International Nuclear Information System (INIS)

    Ashok Kumar; Sarita Kumar; Sunita Kumar

    2000-01-01

    A comprehensive study of elastic scattering of 4n nuclei, namely 16 O + 40 Ca, 24 Mg + 24 Mg and 32 S + 28 Si is carried out at various incident energies near and above the Coulomb barrier using a semi microscopic approach. In the present work real part of the nucleus-nucleus interaction is microscopically calculated using equivalence relation between RGM and GCM

  4. Direct Visualization of Barrier Crossing Dynamics in a Driven Optical Matter System.

    Science.gov (United States)

    Figliozzi, Patrick; Peterson, Curtis W; Rice, Stuart A; Scherer, Norbert F

    2018-04-25

    A major impediment to a more complete understanding of barrier crossing and other single-molecule processes is the inability to directly visualize the trajectories and dynamics of atoms and molecules in reactions. Rather, the kinetics are inferred from ensemble measurements or the position of a transducer ( e. g., an AFM cantilever) as a surrogate variable. Direct visualization is highly desirable. Here, we achieve the direct measurement of barrier crossing trajectories by using optical microscopy to observe position and orientation changes of pairs of Ag nanoparticles, i. e. passing events, in an optical ring trap. A two-step mechanism similar to a bimolecular exchange reaction or the Michaelis-Menten scheme is revealed by analysis that combines detailed knowledge of each trajectory, a statistically significant number of repetitions of the passing events, and the driving force dependence of the process. We find that while the total event rate increases with driving force, this increase is due to an increase in the rate of encounters. There is no drive force dependence on the rate of barrier crossing because the key motion for the process involves a random (thermal) radial fluctuation of one particle allowing the other to pass. This simple experiment can readily be extended to study more complex barrier crossing processes by replacing the spherical metal nanoparticles with anisotropic ones or by creating more intricate optical trapping potentials.

  5. Selected topics in special nuclear materials safeguard system design

    International Nuclear Information System (INIS)

    King, L.L.; Thatcher, C.D.; Clarke, J.D.; Rodriguez, M.P.

    1991-01-01

    During the past two decades the improvements in circuit integration have given rise to many new applications in digital processing technology by continuously reducing the unit cost of processing power. Along with this increase in processing power a corresponding decrease in circuit volume has been achieved. Progress has been so swift that new classes of applications become feasible every 2 or 3 years. This is especially true in the application of proven new technology to special nuclear materials (SNM) safeguard systems. Several areas of application were investigated in establishing the performance requirements for the SNM safeguard system. These included the improvements in material control and accountability and surveillance by using multiple sensors to continuously monitor SNM inventory within the selected value(s); establishing a system architecture to provide capabilities needed for present and future performance requirements; and limiting operating manpower exposure to radiation. This paper describes two selected topics in the application of state-of-the-art, well-proven technology to SNM safeguard system design

  6. An interactive roof bolting selection and performance system

    Energy Technology Data Exchange (ETDEWEB)

    Agioutantis, Z.; Stiakakis, C.; Stiakakis, N. [Technical Univ. of Crete, Chania (Greece); Karmis, M. [Virginia Polytechnic Inst. and State Univ. (United States)

    2001-07-01

    In the last decades, bolting has become one of the most dominant support methods in underground construction, including both mining as well as civil engineering applications. A variety of bolt types has been developed in order to meet the support needs of different geological and geotechnical settings. The selection of the appropriate bolt type, as well as the troubleshooting procedures in case of failure or suspected failure, are often complex and require extensive experience. To facilitate bolt type selection as well as troubleshooting, various tools have been presented in the form of nomograms, computer programs or trouble shooting guides. The approach described in this paper incorporates information and data developed by laboratory and field investigations and has led to the development of a dynamic knowledge base system that can aid in the selection of appropriate bolting systems and, also, help troubleshoot existing installations. Additionally, the user can enhance the functionality of the existing database with site-specific information and geological behavior as experienced by field personnel. The package is developed as a Windows trademark based application, where data is stored in Microsoft Access trademark database. (orig.)

  7. On Secure NOMA Systems with Transmit Antenna Selection Schemes

    KAUST Repository

    Lei, Hongjiang; Zhang, Jianming; Park, Kihong; Xu, Peng; Ansari, Imran Shafique; Pan, Gaofeng; Alomair, Basel; Alouini, Mohamed-Slim

    2017-01-01

    This paper investigates the secrecy performance of a two-user downlink non-orthogonal multiple access systems. Both single-input and single-output and multiple-input and singleoutput systems with different transmit antenna selection (TAS) strategies are considered. Depending on whether the base station has the global channel state information of both the main and wiretap channels, the exact closed-form expressions for the secrecy outage probability (SOP) with suboptimal antenna selection and optimal antenna selection schemes are obtained and compared with the traditional space-time transmission scheme. To obtain further insights, the asymptotic analysis of the SOP in high average channel power gains regime is presented and it is found that the secrecy diversity order for all the TAS schemes with fixed power allocation is zero. Furthermore, an effective power allocation scheme is proposed to obtain the nonzero diversity order with all the TAS schemes. Monte-Carlo simulations are performed to verify the proposed analytical results.

  8. On Secure NOMA Systems with Transmit Antenna Selection Schemes

    KAUST Repository

    Lei, Hongjiang

    2017-08-09

    This paper investigates the secrecy performance of a two-user downlink non-orthogonal multiple access systems. Both single-input and single-output and multiple-input and singleoutput systems with different transmit antenna selection (TAS) strategies are considered. Depending on whether the base station has the global channel state information of both the main and wiretap channels, the exact closed-form expressions for the secrecy outage probability (SOP) with suboptimal antenna selection and optimal antenna selection schemes are obtained and compared with the traditional space-time transmission scheme. To obtain further insights, the asymptotic analysis of the SOP in high average channel power gains regime is presented and it is found that the secrecy diversity order for all the TAS schemes with fixed power allocation is zero. Furthermore, an effective power allocation scheme is proposed to obtain the nonzero diversity order with all the TAS schemes. Monte-Carlo simulations are performed to verify the proposed analytical results.

  9. 77 FR 27263 - Computer Matching Between the Selective Service System and the Department of Education

    Science.gov (United States)

    2012-05-09

    ... SELECTIVE SERVICE SYSTEM Computer Matching Between the Selective Service System and the Department of Education AGENCY: Selective Service System. Action: Notice. In accordance with the Privacy Act of... of Participating Agencies The Selective Service System (SSS) and the Department of Education (ED). 2...

  10. The Development of HfO2-Rare Earth Based Oxide Materials and Barrier Coatings for Thermal Protection Systems

    Science.gov (United States)

    Zhu, Dongming; Harder, Bryan James

    2014-01-01

    Advanced hafnia-rare earth oxides, rare earth aluminates and silicates have been developed for thermal environmental barrier systems for aerospace propulsion engine and thermal protection applications. The high temperature stability, low thermal conductivity, excellent oxidation resistance and mechanical properties of these oxide material systems make them attractive and potentially viable for thermal protection systems. This paper will focus on the development of the high performance and high temperature capable ZrO2HfO2-rare earth based alloy and compound oxide materials, processed as protective coating systems using state-or-the-art processing techniques. The emphasis has been in particular placed on assessing their temperature capability, stability and suitability for advanced space vehicle entry thermal protection systems. Fundamental thermophysical and thermomechanical properties of the material systems have been investigated at high temperatures. Laser high-heat-flux testing has also been developed to validate the material systems, and demonstrating durability under space entry high heat flux conditions.

  11. Community and health systems barriers and enablers to family planning and contraceptive services provision and use in Kabwe District, Zambia.

    Science.gov (United States)

    Silumbwe, Adam; Nkole, Theresa; Munakampe, Margarate Nzala; Milford, Cecilia; Cordero, Joanna Paula; Kriel, Yolandie; Zulu, Joseph Mumba; Steyn, Petrus S

    2018-05-31

    Unmet need for contraception results in several health challenges such as unintended pregnancies, unwanted births and unsafe abortions. Most interventions have been unable to successfully address this unmet need due to various community and health system level factors. Identifying these inhibiting and enabling factors prior to implementation of interventions forms the basis for planning efforts to increase met needs. This qualitative study was part of the formative phase of a larger research project that aimed to develop an intervention to increase met needs for contraception through community and health system participation. The specific study component reported here explores barriers and enablers to family planning and contraceptive services provision and utilisation at community and health systems levels. Twelve focus group discussions were conducted with community members (n = 114) and two with healthcare providers (n = 19). Ten in-depth interviews were held with key stakeholders. The study was conducted in Kabwe district, Zambia. Interviews/discussions were translated and transcribed verbatim. Data were coded and organised using NVivo 10 (QSR international), and were analysed using thematic analysis. Health systems barriers include long distances to healthcare facilities, stock-outs of preferred methods, lack of policies facilitating contraceptive provision in schools, and undesirable provider attitudes. Community level barriers comprise women's experience with contraceptive side effects, myths, rumours and misconceptions, societal stigma, and negative traditional and religious beliefs. On the other hand, health systems enablers consist of political will from government to expand contraceptive services access, integration of contraceptive services, provision of couples counselling, and availability of personnel to offer basic methods mix. Functional community health system structures, community desire to delay pregnancy, and knowledge of contraceptive

  12. Radiation profile measurements for edge transport barrier discharges in Compact Helical System using AXUV photodiode arrays

    International Nuclear Information System (INIS)

    Suzuki, C.; Okamura, S.; Minami, T.; Akiyama, T.; Fujisawa, A.; Ida, K.; Isobe, M.; Matsuoka, K.; Nagaoka, K.; Nishimura, S.; Peterson, B. J.; Shimizu, A.; Takahashi, C.; Toi, K.; Yoshimura, Y.

    2005-01-01

    The formation of edge transport barrier (ETB) has recently been found in Compact Helical System (CHS) plasmas heated by co-injected neutral beam injection (NBI) with strong gas puffing. This regime is characterized by the appearance of the steep gradient of the electron density near the edge following the abrupt drop of hydrogen Balmer alpha (H α ) line intensity. In addition to single channel pyroelectric detector as a conventional bolometer, we have employed unfiltered absolute extreme ultraviolet (AXUV) photodiode arrays as a simple and low-cost diagnostic to investigate spatial and temporal variations of radiation emissivity in the ETB discharges. A compact mounting module for a 20 channel AXUV photodiode array including an in-vacuum preamplifier for immediate current-voltage conversion has successfully been designed and fabricated. Two identical modules installed in the upper and lower viewports provide 40 lines of sight covering the inboard and outboard sides within the horizontally elongated cross section of the CHS plasma with wide viewing angle. Although spectral uniformity of the detector sensitivity of the AXUV photodiode is unsatisfied for photon energies lower than 200 eV, it has been confirmed that the signals of AXUV photodiode and pyroelectric detector in the ETB discharges show roughly the same behavior except for the very beginning and end of the discharges. The results of the measurements in typical ETB discharges show that the signals of all the channels of the AXUV photodiode arrays begin to increase more rapidly at the moment of the transition than before. The rate of the increase is larger for the edge viewing chords than for the center viewing ones, which indicates the flattening of the radiation profile following the change in the electron density profile after the formation of the ETB. However, the signals for the edge chords tend to saturate after several tens of milliseconds, while they still continue to increase for the central chords

  13. An Antibiotic Selection System For Protein Overproducing Bacteria

    DEFF Research Database (Denmark)

    Rennig, Maja; Nørholm, Morten

    2015-01-01

    Introduction: Protein overproduction is a major bottleneck for analyses of membrane proteins and for the construction of cell factories. Screening for optimized protein production can be very time consuming. In this study we show that the coupling of antibiotic resistance to poorly produced...... membrane proteins of Escherichia coli can be used as a fast and simple selection system for protein overproduction.Methods: We designed an expression plasmid encoding the gene of interest and an additional, inducible antibiotic resistance marker. Both genes were linked by a hairpin structure...... that translationally couples the genes. Consequently, high expressing gene variants also allow for higher production of the coupled antibiotic resistance marker. Therefore, high expressing gene variants in a library can be determined either by plating the expression library on selection plates or by growing...

  14. Optical Selection Rule of Excitons in Gapped Chiral Fermion Systems

    Science.gov (United States)

    Zhang, Xiaoou; Shan, Wen-Yu; Xiao, Di

    2018-02-01

    We show that the exciton optical selection rule in gapped chiral fermion systems is governed by their winding number w , a topological quantity of the Bloch bands. Specifically, in a CN-invariant chiral fermion system, the angular momentum of bright exciton states is given by w ±1 +n N with n being an integer. We demonstrate our theory by proposing two chiral fermion systems capable of hosting dark s -like excitons: gapped surface states of a topological crystalline insulator with C4 rotational symmetry and biased 3 R -stacked MoS2 bilayers. In the latter case, we show that gating can be used to tune the s -like excitons from bright to dark by changing the winding number. Our theory thus provides a pathway to electrical control of optical transitions in two-dimensional material.

  15. The selection criteria elements of X-ray optics system

    Science.gov (United States)

    Plotnikova, I. V.; Chicherina, N. V.; Bays, S. S.; Bildanov, R. G.; Stary, O.

    2018-01-01

    At the design of new modifications of x-ray tomography there are difficulties in the right choice of elements of X-ray optical system. Now this problem is solved by practical consideration, selection of values of the corresponding parameters - tension on an x-ray tube taking into account the thickness and type of the studied material. For reduction of time and labor input of design it is necessary to create the criteria of the choice, to determine key parameters and characteristics of elements. In the article two main elements of X-ray optical system - an x-ray tube and the detector of x-ray radiation - are considered. Criteria of the choice of elements, their key characteristics, the main dependences of parameters, quality indicators and also recommendations according to the choice of elements of x-ray systems are received.

  16. System for selecting relevant information for decision support.

    Science.gov (United States)

    Kalina, Jan; Seidl, Libor; Zvára, Karel; Grünfeldová, Hana; Slovák, Dalibor; Zvárová, Jana

    2013-01-01

    We implemented a prototype of a decision support system called SIR which has a form of a web-based classification service for diagnostic decision support. The system has the ability to select the most relevant variables and to learn a classification rule, which is guaranteed to be suitable also for high-dimensional measurements. The classification system can be useful for clinicians in primary care to support their decision-making tasks with relevant information extracted from any available clinical study. The implemented prototype was tested on a sample of patients in a cardiological study and performs an information extraction from a high-dimensional set containing both clinical and gene expression data.

  17. Barrier penetration database

    International Nuclear Information System (INIS)

    Fainberg, A.; Bieber, A.M. Jr.

    1978-11-01

    This document is intended to supply the NRC and nuclear power plant licensees with basic data on the times required to penetrate forcibly the types of barriers commonly found in nuclear plants. These times are necessary for design and evaluation of the physical protection system required under 10CFR73.55. Each barrier listed is described in detail. Minor variations in basic barrier construction that result in the same penetration time, are also described

  18. Selecting a pharmacy layout design using a weighted scoring system.

    Science.gov (United States)

    McDowell, Alissa L; Huang, Yu-Li

    2012-05-01

    A weighted scoring system was used to select a pharmacy layout redesign. Facilities layout design techniques were applied at a local hospital pharmacy using a step-by-step design process. The process involved observing and analyzing the current situation, observing the current available space, completing activity flow charts of the pharmacy processes, completing communication and material relationship charts to detail which areas in the pharmacy were related to one another and how they were related, researching applications in other pharmacies or in scholarly works that could be beneficial, numerically defining space requirements for areas within the pharmacy, measuring the available space within the pharmacy, developing a set of preliminary designs, and modifying preliminary designs so they were all acceptable to the pharmacy staff. To select a final layout that could be implemented in the pharmacy, those layouts were compared via a weighted scoring system. The weighted aspect further allowed additional emphasis on categories based on their effect on pharmacy performance. The results produced a beneficial layout design as determined through simulated models of the pharmacy operation that more effectively allocated and strategically located space to improve transportation distances and materials handling, employee utilization, and ergonomics. Facilities layout designs for a hospital pharmacy were evaluated using a weighted scoring system to identify a design that was superior to both the current layout and alternative layouts in terms of feasibility, cost, patient safety, employee safety, flexibility, robustness, transportation distance, employee utilization, objective adherence, maintainability, usability, and environmental impact.

  19. Risk-informed decision-making analysis for the electrical raceway fire barrier systems on a BWR-4 plant

    International Nuclear Information System (INIS)

    Wu, Ching-Hui; Lin, Tsu-Jen; Kao, Tsu-Mu; Chen, Chyn-Rong

    2003-01-01

    This paper describes a risk-informed decision-making approach used to resolve the fire barrier issue in a BWR-4 nuclear plant where Appendix R separation requirements cannot be met without installing additional fire protection features such as electrical raceway fire barrier system. The related risk measures in CDF (core damage frequency) and LERF (large early release frequency) of the fire barrier issue can be determined by calculating the difference in plant risks between various alternative cases and that met the requirement of the Appendix R. In some alternative cases, additional early-detection and fast-response fire suppression systems are suggested. In some other cases, cable re-routing of some improper layout of non-safety related cables are required. Sets of fire scenarios are re-evaluated more detailed by reviewing the cable damage impact for the BWR-4 plant. The fire hazard model, COMPBRM III-e, is used in this study and the dominant results in risk measures are benchmarked with the CFD code, FDS 2.0, to ensure that the risk impact of fire barrier is estimated accurately in the risk-informed decision making. The traditional deterministic qualitative methods, such as defense-in-depth, safety margin and post-fire safety shutdown capability are also proceeded. The value-impact analysis for proposed alternatives of fire wrapping required by Appendix R has been completed for technical basis of the exemption on Appendix R application. The outcome of the above analysis should be in compliance with the regulatory guidelines (RG) 1.174 and 1.189 for the applications in the risk-informed decision-making of the fire wrapping issues. (author)

  20. Chemical buffering in natural and engineered barrier systems: Thermodynamic constraints and performance assessment consequences

    International Nuclear Information System (INIS)

    Arthur, R.C.; Wei Zhou

    2000-12-01

    Thermodynamic and kinetic constraints on the chemical buffering properties of natural and engineered-barrier systems are derived in this study from theoretical descriptions, incorporated in the reaction-path model, of reversible and irreversible mass transfer in multicomponent, multiphase systems. The buffering properties of such systems are conditional properties because they refer to a specific aqueous species in a system that is open with respect to a specific reactant. The solution to a mathematical statement of this concept requires evaluation of the dependence of the activity of the buffered species on incremental changes in the overall reaction-progress variable. This dependence can be represented by a truncated Taylor's series expansion, where the values of associated derivatives are calculated using finite-difference techniques and mass-balance, charge-balance and mass-action constraints. Kinetic constraints on buffering behavior can also be described if the relation between reactant flux and reaction rate is well defined. This relation is explicit for the important case of advective groundwater flow and water-rock interaction. We apply the theoretical basis of the chemical buffering concept to processes that could affect the performance of a deep geologic repository for nuclear waste. Specifically, we focus on the likelihood that an inverse relation must exist between the buffer intensity and the migration velocity of reaction fronts in systems involving advective or diffusive mass transport. A quantitative understanding of this relation would provide the basis for evaluating the potential role of chemical buffering in achieving the isolation and retardation functions, of the EBS and geosphere in a KBS-3 repository. Our preliminary evaluation of this role considers the effects of chemical buffering on the propagation velocity of a pH front in both the near- and far field. We use a geochemical modeling technique compatible with the reaction-path model to