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Sample records for bacteriophage lambda

  1. Bacteriophage Lambda as a Cloning Vector

    OpenAIRE

    Chauthaiwale, V M; Therwath, A; Deshpande, V V

    1993-01-01

    Extensive research has been directed toward the development of multipurpose lambda vectors for cloning ever since the potential of using coliphage lambda as a cloning vector was recognized in the late 1970s. An understanding of the intrinsic molecular organization and of the genetic events which determine lysis or lysogeny in lambda has allowed investigators to modify it to suit the specific requirements of gene manipulations. Unwanted restriction sites have been altered and arranged together...

  2. Bacteriophage lambda as a cloning vector.

    Science.gov (United States)

    Chauthaiwale, V M; Therwath, A; Deshpande, V V

    1992-12-01

    Extensive research has been directed toward the development of multipurpose lambda vectors for cloning ever since the potential of using coliphage lambda as a cloning vector was recognized in the late 1970s. An understanding of the intrinsic molecular organization and of the genetic events which determine lysis or lysogeny in lambda has allowed investigators to modify it to suit the specific requirements of gene manipulations. Unwanted restriction sites have been altered and arranged together into suitable polylinkers. The development of a highly efficient in vitro packaging system has permitted the introduction of chimeric molecules into hosts. Biological containment of recombinants has been achieved by introducing amber mutations into the lambda genome and by using specific amber suppressor hosts. Taking advantage of the limited range of genome size (78 to 105% of the wild-type size) for its efficient packaging, an array of vectors has been devised to accommodate inserts of a wide size range, the limit being 24 kbp in Charon 40. The central dispensable fragment of the lambda genome can be replaced by a fragment of heterologous DNA, leading to the construction of replacement vectors such as Charon and EMBL. Alternatively, small DNA fragments can be inserted without removing the dispensable region of the lambda genome, as in lambda gt10 and lambda gt11 vectors. In addition, the introduction of many other desirable properties, such as NotI and SfiI sites in polylinkers (e.g., lambda gt22), T7 and T3 promoters for the in vitro transcription (e.g., lambda DASH), and the mechanism for in vivo excision of the intact insert (e.g., lambda ZAP), has facilitated both cloning and subsequent analysis. In most cases, the recombinants can be differentiated from the parental phages by their altered phenotype. Libraries constructed in lambda vectors are screened easily with antibody or nucleic acid probes since several thousand clones can be plated on a single petri dish. Besides

  3. Minimal gene regulatory circuits that can count like bacteriophage lambda.

    Science.gov (United States)

    Avlund, M; Dodd, Ian B; Sneppen, K; Krishna, S

    2009-12-11

    The behavior of living systems is dependent on large dynamical gene regulatory networks (GRNs). However, the functioning of even the smallest GRNs is difficult to predict. The bistable GRN of bacteriophage lambda is able to count to make a decision between lysis and lysogeny on the basis of the number of phages infecting the cell, even though replication of the phage genome eliminates this initial difference. By simulating the behavior of a large number of random transcriptional GRNs, we show that a surprising variety of GRNs can carry out this complex task, including simple CI-Cro-like mutual repression networks. Thus, our study extends the repertoire of simple GRNs. Counterintuitively, the major effect of the addition of CII-like regulation, generally thought to be needed for counting by lambda, was to improve the ability of the networks to complete a simulated prophage induction. Our study suggests that additional regulatory mechanisms to decouple Cro and CII levels may exist in lambda and that infection counting could be widespread among temperate bacteriophages, many of which contain CI-Cro-like circuits. PMID:19796646

  4. Induction of genetic recombination in the lambda bacteriophage by ultraviolet radiation of the Escherichia Coli cells

    International Nuclear Information System (INIS)

    In this work there are reported the results that show that although the stimulation of the recombination of the Lambda bacteriophage, by UV irradiation of the cells of Escherichia Coli, it looks to be the result of the high expression of the functions of the SOS system, doesn't keep some relationship with the high concentration of protein reached RecA. (Author)

  5. A cII-dependent promoter is located within the Q gene of bacteriophage lambda.

    OpenAIRE

    Hoopes, B C; McClure, W R

    1985-01-01

    We have found a cII-dependent promoter, PaQ, within the Q gene of bacteriophage lambda. Transcription experiments and abortive initiation assays performed in vitro showed that the promoter strength and the cII affinity of PaQ were comparable to the other cII-dependent lambda promoters, PE and PI. The location and leftward direction of PaQ suggests a possible role in the delay of lambda late-gene expression by cII protein, a phenomenon that has been called cII-dependent inhibition. We have con...

  6. A cII-dependent promoter is located within the Q gene of bacteriophage lambda.

    Science.gov (United States)

    Hoopes, B C; McClure, W R

    1985-05-01

    We have found a cII-dependent promoter, PaQ, within the Q gene of bacteriophage lambda. Transcription experiments and abortive initiation assays performed in vitro showed that the promoter strength and the cII affinity of PaQ were comparable to the other cII-dependent lambda promoters, PE and PI. The location and leftward direction of PaQ suggests a possible role in the delay of lambda late-gene expression by cII protein, a phenomenon that has been called cII-dependent inhibition. We have constructed a promoter down mutation, paq-1, by changing a single base pair in the putative cII binding site of the promoter by oligonucleotide site-directed mutagenesis. The paq-1 mutant promoter required about 4-fold higher cII concentrations for maximal activation compared to the wild-type PaQ. We tested the hypothesis that PaQ is responsible in part for the delay of lambda late-gene expression by recombining the paq-1 mutation into a phage showing severe cII-dependent inhibition. We found that the paq-1 mutation relieved the cII-dependent growth defect of this phage. The paq-1 mutation (in combination with lambda cI857) resulted in a clear-plaque phenotype at the permissive temperature of 32 degrees C. The role of the PaQ-initiated antisense transcript in the control of lambda development is discussed.

  7. Cooperativity Leads to Temporally-Correlated Fluctuations in the Bacteriophage Lambda Genetic Switch

    Directory of Open Access Journals (Sweden)

    Jacob Quinn Shenker

    2015-04-01

    Full Text Available Cooperative interactions are widespread in biochemical networks, providing the nonlinear response that underlies behavior such as ultrasensitivity and robust switching. We introduce a temporal correlation function—the conditional activity—to study the behavior of these phenomena. Applying it to the bistable genetic switch in bacteriophage lambda, we find that cooperative binding between binding sites on the prophage DNA lead to non-Markovian behavior, as quantified by the conditional activity. Previously, the conditional activity has been used to predict allosteric pathways in proteins; here, we show that it identifies the rare unbinding events which underlie induction from lysogeny to lysis.

  8. The lambda red proteins promote efficient recombination between diverged sequences: implications for bacteriophage genome mosaicism.

    Directory of Open Access Journals (Sweden)

    Jann T Martinsohn

    2008-05-01

    Full Text Available Genome mosaicism in temperate bacterial viruses (bacteriophages is so great that it obscures their phylogeny at the genome level. However, the precise molecular processes underlying this mosaicism are unknown. Illegitimate recombination has been proposed, but homeologous recombination could also be at play. To test this, we have measured the efficiency of homeologous recombination between diverged oxa gene pairs inserted into lambda. High yields of recombinants between 22% diverged genes have been obtained when the virus Red Gam pathway was active, and 100 fold less when the host Escherichia coli RecABCD pathway was active. The recombination editing proteins, MutS and UvrD, showed only marginal effects on lambda recombination. Thus, escape from host editing contributes to the high proficiency of virus recombination. Moreover, our bioinformatics study suggests that homeologous recombination between similar lambdoid viruses has created part of their mosaicism. We therefore propose that the remarkable propensity of the lambda-encoded Red and Gam proteins to recombine diverged DNA is effectively contributing to mosaicism, and more generally, that a correlation may exist between virus genome mosaicism and the presence of Red/Gam-like systems.

  9. Direct positive selection for improved nitroreductase variants using SOS triggering of bacteriophage lambda lytic cycle.

    Science.gov (United States)

    Guise, C P; Grove, J I; Hyde, E I; Searle, P F

    2007-04-01

    Expression of prodrug-activating enzymes that convert non-toxic substrates to cytotoxic derivatives is a promising strategy for cancer gene therapy. However, their catalytic activity with unnatural, prodrug substrates is often suboptimal. Efforts to improve these enzymes have been limited by the inability to select directly for increased prodrug activation. We have focussed on developing variants of Escherichia coli (E. coli) nitroreductase (NTR) with improved ability to activate the prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954), and describe here a novel, direct, positive selection for improved enzymes that exploits the alternative life cycles of bacteriophage lambda. In lambda lysogens of E. coli, the activation of the prodrug CB1954 by NTR triggers the SOS response to DNA damage, switching integrated lambda prophages into lytic cycle. This provides a direct, positive selection for phages encoding improved NTR variants, as, upon limiting exposure of lysogenized E. coli to CB1954, only those encoding the most active enzyme variants are triggered into lytic cycle, allowing their selective recovery. We exemplify the selection by isolating highly improved 'turbo-NTR' variants from a library of 6.8 x 10(5) clones, conferring up to 50-fold greater sensitivity to CB1954 than the wild type. Carcinoma cells infected with adenovirus expressing T41Q/N71S/F124T-NTR were sensitized to CB1954 concentrations 40- to 80-fold lower than required with WT-NTR. PMID:17301844

  10. Analysis of lambda insertions in the fucose utilization region of Escherichia coli K-12: use of lambda fuc and lambda argA transducing bacteriophages to partially order the fucose utilization genes.

    OpenAIRE

    Skjold, A C; Ezekiel, D H

    1982-01-01

    Escherichia coli K-12 strains have deletions for the normal lambda integration site were lysogenized with bacteriophage lambda at a site within the L-fucose utilization system (fuc). The frequency of lambda integration at this site is approximately 2 X 10(-8) to 5 X 10(-7). Studies of the lytic properties of these strains indicated very infrequent cell lysis with a relatively low phage burst size. Transductional ability of the phage lysates was found to be normal, comparable to that found in ...

  11. Display of aggregation-prone ligand binding domain of human PPAR gamma on surface of bacteriophage lambda

    Institute of Scientific and Technical Information of China (English)

    Bo KONG; Wei-jun MA

    2006-01-01

    Aim: To display the aggregation-prone ligand binding domain (LBD) of the human peroxisome proliferator-activated receptor gamma (PPARγ) on the surface of bacteriophages to establish an easy screening assay for the identification of PPARγ ligands. Methods: Plasmids were constructed for the expression of the PPARγ LBD as a fusion to the N-terminus of the g3p protein of filamentous phage or the C-terminus of the capsid protein D (pD) of phage lambda. The fusion proteins were expressed in E coli and solubility characteristics were compared. Polyclonal antibodies against the LBD as well as the pD protein were prepared for Western blot analysis and phage capture assay. Results: The pD-LBD fusion protein was partially soluble, whereas the LBD-g3p fusion protein was detected only in the insoluble fraction. The pD-LBD fusion protein was efficiently incorporated in phage particles. Furthermore, the LBD was shown to be displayed on the surface of bacteriophage lambda. On average, the pD-LBD fusion protein accounted for 28% of the total pD protein in the lambda head capsid. Conclusion: The hydrophobic PPARγLBD was expressed as a soluble form of fusionprotein in E coli and displayed on the surface of bacteriophage lambda when it was fused to the lambda pD protein. The lambda pD fusion system could be used for improving the solubility of proteins that tend to form inclusion bodies when expressed in E coli. The lambda phage particles displaying the LBD of PPARγ may be of great value for the identification of novel PPARγ ligands.

  12. Posttranscriptional control of bacteriophage lambda gene expression from a site distal to the gene.

    Science.gov (United States)

    Guarneros, G; Montañez, C; Hernandez, T; Court, D

    1982-01-01

    The bacteriophage lambda int gene product, integrase, recombines the phage DNA with the host DNA at specific sites on each to accomplish lysogeny. The int gene is transcribed from two promoters, PL and PI, each regulated positively by lambda proteins. The expression of integrase is also controlled from a site, sib, in the b region of the phage genome. This is a unique regulatory site because it is located distal to the structural gene in relation to the promoters. The expression of int from the PL promoter is inhibited when sib is present. This effect appears to be specific for PL because sib does not cause inhibition of PI-dependent int synthesis. lambda mutants that contain alterations in the site have been isolated. Sequence analyses of the mutations reveal single base changes, spanning 37 base pairs (bp) in the b region, some 240 bp beyond the int gene. Another mutant, hef13, which has a phenotype similar to that of sib, introduces a nucleotide change within the same 37-bp region. The sib and hef mutations cluster within a region of dyad symmetry. Regulation of int synthesis by sib occurs after transcription of the int gene. There is no difference in the rate of PL-promoted int mRNA synthesis in either sib+ or sib- phage infections, yet int mRNA is less stable in the sib+ infection. Because RNase III host mutants are defective in sib regulation, processing of the PL mRNA at sib by this endoribonuclease may cause int mRNA decay and decrease int synthesis. PMID:6281759

  13. Revisiting bistability in the lysis/lysogeny circuit of bacteriophage lambda.

    Directory of Open Access Journals (Sweden)

    Michael Bednarz

    Full Text Available The lysis/lysogeny switch of bacteriophage lambda serves as a paradigm for binary cell fate decision, long-term maintenance of cellular state and stimulus-triggered switching between states. In the literature, the system is often referred to as "bistable." However, it remains unclear whether this term provides an accurate description or is instead a misnomer. Here we address this question directly. We first quantify transcriptional regulation governing lysogenic maintenance using a single-cell fluorescence reporter. We then use the single-cell data to derive a stochastic theoretical model for the underlying regulatory network. We use the model to predict the steady states of the system and then validate these predictions experimentally. Specifically, a regime of bistability, and the resulting hysteretic behavior, are observed. Beyond the steady states, the theoretical model successfully predicts the kinetics of switching from lysogeny to lysis. Our results show how the physics-inspired concept of bistability can be reliably used to describe cellular phenotype, and how an experimentally-calibrated theoretical model can have accurate predictive power for cell-state switching.

  14. The levanase operon of Bacillus subtilis expressed in Escherichia coli can substitute for the mannose permease in mannose uptake and bacteriophage lambda infection.

    OpenAIRE

    Martin-Verstraete, I; Michel, V. (Dr.); Charbit, A.

    1996-01-01

    Bacteriophage lambda adsorbs to its Escherichia coli K-12 host by interacting with LamB, a maltose- and maltodextrin-specific porin of the outer membrane. LamB also serves as a receptor for several other bacteriophages. Lambda DNA requires, in addition to LamB, the presence of two bacterial cytoplasmic integral membrane proteins for penetration, namely, the IIC(Man) and IID(Man) proteins of the E. coli mannose transporter, a member of the sugar-specific phosphoenolpyruvate:sugar phosphotransf...

  15. Radiation biophysicl study of biological molecules. Progress report, February 1, 1975--June 30, 1976. [Fast electrons, gamma and uv radiation, Escherichia coli, T1 and lambda bacteriophages

    Energy Technology Data Exchange (ETDEWEB)

    Fluke, D.J.

    1976-01-01

    Progress is reported on the following research projects: direct action target investigation of molecular weights of enzymes exposed to fast electrons; direct action gamma radiation dosimetry with T/sub 1/ bacteriophage; uv radiation sensitivity of T/sub 1/ bacteriophage on various host strains of E. coli; temperature dependence of uv radiation direct action on dry T/sub 1/ bacteriophage; investigation of light and temperature effects during incubation of T/sub 1/ bacteriophage exposed to fast electrons; test of superoxide anion as a radiation intermediate in cellular radiobiology; uv action spectra related to error-prone repair; uv-reactivation experiments with T/sub 1/ and lambda bacteriophages; and split-dose uv mutagenesis in E. coli. (HLW)

  16. W-reactivation and W-mutagenesis in bacteriophages lambda and T7: comparison of action of ultraviolet irradiation (254nm) and furocouma photosensitization

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    Zavil' gel' skij, G.B.; Belogurov, A.A.; Kryuger, D.N. (AN SSSR, Moscow. Inst. Molekulyarnoj Biologii; Humboldt-Universitaet, Berlin (German Democratic Republic))

    1982-01-01

    When treating bacteriophage lambda with 8-methoxypsoralen (8-MOP) and light (lambda>320 nm), two types of photoproducts are formed in DNA: monoadducts and diadducts or interstrand linkings. If a wild-type strain of Escherichia coli is used as host, W-reactivation and W-mutagenesis (clear-mutation), approximately equal in magnitude to those of UV-irradiated phage lambda, are observed in the bacteriophage lambda treated with 8-MOP plus light. If mutant strains E coli uvrA/sup -/, recA/sup -/ and lexA/sup -/ are used as host W-reactivation and W-mutagenesis practically do not occur in phage lambda. Using the method of ''reirradiation'', it is shown that clear-mutations in 8-MOP plus light treated phage lambda are induced in the process of W-mutagenesis mainly due to the formation of diadducts (interstrand linking) in DNA. In the phage monoadducts of derived furocoumarins also have a mutageneous character but their mutagenesis effectiveness (mutation probability calculating on one photo product) is significantly inferior to that of diadducts (approximately 15-20 times). It has been demonstrated in the experiments on the determination of W-mutagenesis of phage lambda photosensitized with angelisine - an angular derivative of furocoumarins - that mainly form monoadducts in DNA. It is also shown that W-reactivation and W-mutagenesis effects are observed when sowing UV-irradiated (254 nm) phage lambda on E coli uvrA/sup -/ and wild-type strains treated with 8-MOP plus light. As to bacteriophage T7 treated with 8-MOP plus light, W-reactivation is not observed even on a wild strain E coli. Preliminary infection of cells with phage T7 that has been strongly inactivated using photosensitizer 8-MOP decreases repair's effectiveness of interstrand linkings in DNA of phage lambda.

  17. Effect of the mutation of recB21 of Escherichia coli on indirect recombinogenesis of bacteriophage lambda

    International Nuclear Information System (INIS)

    In this work two undamaged amber lambda mutants were crossed in UV-irradiated Escherichia coli host cells and the total and recombinant λ + progenies scored after one lytic cycle. In a wild - type strain, such treatment produces an stimulation of 5-7 times in the production of recombinant λ + particles, accompanied by a variable but consistent increase in the total phage pro genie too. The effect has been designed as indirect recombinogenesis of bacteriophage lambda because it is elicited among undamaged λ genomes by the UV irradiation of host cells. Through the use of recB21 mutants we tested the role of the RecBCD enzyme as a whole in the effect just described and observed that in those hosts the effect is absent. The RecBCD enzyme of Escherichia coli has different activities, important for both the genetic recombination and recovery from DNA damage. Among those activities is that of ATP-dependent double-stranded DNA exonuclease, by means of which the enzyme digests the lineal molecules of viral DNA, produced during the late phase of lambda lytic cycle. To face such a destructive activity, λ encodes the Gam protein which inhibits all the activities of RecBCD; so the ability of RecBCD to act in the phage response, may be due either to a residual activity of the enzyme in lambda infected host cells or to an unknown Gam non-inhibited activity of the RecBCD enzyme. because the synthesis of the RecBCD is constitutive, the apparent inducibility of the λ response should be due to another reason such as an increase in the molecular substrates on which the enzyme acts. (Author)

  18. Translesion synthesis is the main component of SOS repair in bacteriophage lambda DNA.

    OpenAIRE

    Defais, M; Lesca, C; Monsarrat, B.; Hanawalt, P

    1989-01-01

    Agents that interfere with DNA replication in Escherichia coli induce physiological adaptations that increase the probability of survival after DNA damage and the frequency of mutants among the survivors (the SOS response). Such agents also increase the survival rate and mutation frequency of irradiated bacteriophage after infection of treated bacteria, a phenomenon known as Weigle reactivation. In UV-irradiated single-stranded DNA phage, Weigle reactivation is thought to occur via induced, e...

  19. Isolation and analysis of Escherichia coli mutants that allow increased replication of bacteriophage lambda.

    OpenAIRE

    Keller, J A; Simon, L D

    1987-01-01

    Escherichia coli mutants were isolated that supported the growth of a lambda Ots and, in at least one case, a lambda Bts phage at the normally nonpermissive temperature of 39 degrees C. In one such strain, Ots and Bts suppression ability appeared to be a function of the guaB gene. Ots suppression by the mutant guaB strain was prevented if high levels of guanine or xanthine were present in the medium. No other base had any effect on Ots suppression in this strain. Other strains carrying sponta...

  20. Induction of genetic recombination in the lambda bacteriophage by ultraviolet radiation of the Escherichia Coli cells; Induccion de recombinacion genetica en el bacteriofago lambda por irradiacion ultravioleta de las cellulas de Escherichia Coli

    Energy Technology Data Exchange (ETDEWEB)

    Alcantara D, D. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    1986-12-15

    In this work there are reported the results that show that although the stimulation of the recombination of the Lambda bacteriophage, by UV irradiation of the cells of Escherichia Coli, it looks to be the result of the high expression of the functions of the SOS system, doesn't keep some relationship with the high concentration of protein reached RecA. (Author)

  1. Entropy Production Rate Changes in Lysogeny/Lysis Switch Regulation of Bacteriophage Lambda*

    Institute of Scientific and Technical Information of China (English)

    DING Hui; LUO Liao-Fu; LIN Hao

    2011-01-01

    According to the chemical kinetic model of lysogeny/lysis switch in Escherichia coli (E. coli) intected by bacteriophage λ, the entropy production rates of steady states are calculated. The results show that the lysogenic state has lower entropy production rate than lytic state, which provides an explanation on why the lysogenic state of λ phage is so stable. We also notice that the entropy production rates of both lysogenic state and lytic state are lower than that of saddle-point and bifurcation state, which is consistent with the principle of minimum entropy production for living organism in nonequilibrium stationary state. Subsequently, the relations between CI and Cro degradation rates at two bifurcations and the changes of entropy production rate with CI and Cro degradation are deduced. The theory and method can be used to calculate entropy change in other molecular network.

  2. Analysis of the viral progeny during the indirect recombinogenesis of the lambda bacteriophage

    International Nuclear Information System (INIS)

    In this work the effect of the UV irradiation on the number of cells that follow the lytic via of the phage is determined, as well as the production of total particles and recombinants in irradiated individual cells and not irradiated with light UV. The results show that the indirect recombinogenesis of lambda is caused by a so much increment in the number of recombinant phages for cells like in the number of cells in those that happen events of viral recombination, without any significant effect on the number of bacteria that follow the lytic via of viral development. (Author)

  3. Cloning and characterization of the c1 repressor of Pseudomonas aeruginosa bacteriophage D3: a functional analog of phage lambda cI protein

    International Nuclear Information System (INIS)

    We cloned the gene (c1) which encodes the repressor of vegetative function of Pseudomonas aeruginosa bacteriophage D3. The cloned gene was shown to inhibit plating of D3 and the induction of D3 lysogens by UV irradiation. The efficiency of plating and prophage induction of the heteroimmune P. aeruginosa phage F116L were not affected by the presence of the cloned c1 gene of D3. When the D3 DNA fragment containing c1 was subcloned into pBR322 and introduced into Escherichia coli, it was shown to specifically inhibit the plating of phage lambda and the induction of the lambda prophage by mitomycin C. The plating of lambda imm434 phage was not affected. Analysis in minicells indicated that these effects correspond to the presence of a plasmid-encoded protein of 36,000 molecular weight. These data suggest the possibility that coliphage lambda and the P. aeruginosa phage D3 evolved from a common ancestor. The conservation of the functional similarities of their repressors may have occurred because of the advantage to these temperate phages of capitalizing on the potential of the evolutionarily conserved RecA protein to monitor the level of damage to the host genome

  4. Effect of the psi B gene on the indirect recombinogenesis of the lambda bacteriophage; Efecto del gen psi B sobre la recombinogenesis indirecta del bacteriofago lambda

    Energy Technology Data Exchange (ETDEWEB)

    Alcantara D, D. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    1993-10-15

    Presently work, we prove if the protein psi B suppresses the indirect recombinogenesis of lambda when inhibiting the induction of the system bacterial SOS. This experimental model's advantage is that it allows to exclude the activity of co protease of RecA selectively without affecting the activity of recombinases of the same one, making possible the analysis of the paper that play both functions in the phenomenon. The results show that the inhibition of the activity of co protease of RecA doesn't suppress the indirect recombinogenesis of lambda. (Author)

  5. A human Fab fragment specific for thyroid peroxidase generated by cloning thyroid lymphocyte-derived immunoglobulin genes in a bacteriophage lambda library.

    Science.gov (United States)

    Portolano, S; Seto, P; Chazenbalk, G D; Nagayama, Y; McLachlan, S M; Rapoport, B

    1991-08-30

    A human Fab fragment (SP2) which binds specifically to human thyroid peroxidase has been generated by expressing random combinations of heavy and light chain immunoglobulin genes (derived from Graves' thyroid cDNA) in a bacteriophage lambda library. In common with many serum TPO autoantibodies, the cloned Fab fragment is IgG1 kappa and has a high affinity for TPO (approximately 10(-9) M). On the basis of their nucleotide sequences, the heavy and light chain genes coding for SP2 belong to families VHI, (D), JH3 and VKI, JK2, respectively. These data provide the first characterization at a molecular level of a human thyroid peroxidase antibody associated with autoimmune thyroid disease.

  6. Salt-Dependent DNA-DNA Spacings in Intact Bacteriophage lambda Reflect Relative Importance of DNA Self-Repulsion and Bending Energies

    Energy Technology Data Exchange (ETDEWEB)

    X Qiu; D Rau; V Parsegian; L Fang; C Knobler; W Gelbart

    2011-12-31

    Using solution synchrotron x-ray scattering, we measure the variation of DNA-DNA d spacings in bacteriophage {lambda} with mono-, di-, and polyvalent salt concentrations, for wild-type [48.5 x 10{sup 3} base pairs (bp)] and short-genome-mutant (37.8 kbp) strains. From the decrease in d spacings with increasing salt, we deduce the relative contributions of DNA self-repulsion and bending to the energetics of packaged phage genomes. We quantify the DNA-DNA interaction energies within the intact phage by combining the measured d spacings in the capsid with measurements of osmotic pressure in DNA assemblies under the same salt conditions in bulk solution. In the commonly used Tris-Mg buffer, the DNA-DNA interaction energies inside the phage capsids are shown to be about 1 kT/bp, an order of magnitude larger than the bending energies.

  7. Analysis of the viral progeny during the indirect recombinogenesis of the lambda bacteriophage; Analisis de la progenie viral durante la recombinogenesis indirecta del bacteriofago lambda

    Energy Technology Data Exchange (ETDEWEB)

    Alcantara D, D. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    1993-12-15

    In this work the effect of the UV irradiation on the number of cells that follow the lytic via of the phage is determined, as well as the production of total particles and recombinants in irradiated individual cells and not irradiated with light UV. The results show that the indirect recombinogenesis of lambda is caused by a so much increment in the number of recombinant phages for cells like in the number of cells in those that happen events of viral recombination, without any significant effect on the number of bacteria that follow the lytic via of viral development. (Author)

  8. Current advance in the topological structure and function of holin encoded by bacteriophage Lambda-A review%λ噬茵体穿孔素(holin)蛋白触发裂菌的分子机制

    Institute of Scientific and Technical Information of China (English)

    史一博; 孙建和

    2012-01-01

    穿孔素-裂解酶二元裂解系统是双链DNA噬菌体普遍采用的裂菌模式,以λ噬菌体为例,系统地揭示了噬菌体穿孔素的结构与功能.λ噬菌体的S基因的特征是呈双起始基序( dual-start motif),编码穿孔素(holin) S105和抗穿孔素(antiholin) S107,通过二者不同水平的表达及相互作用,触发裂菌过程.作者综述了λ噬菌体穿孔素的膜拓扑结构和成孔机制的最新研究进展,并展望了穿孔素的研究热点和应用前景.%The holin-lysin two-step lysis system widely exists in double stranded DNA bacteriophages for the release of progeny bacteriophage from an infected bacterial cell at the final stage of phage infection. Lambda bacteriophage is a prototype for studying holin. The S gene in Lambda bacteriophage has a dual-start motif and encodes holin S105 and antiholin S107. Here, we reviewed the progress in topological structure of holin from Lambda bacteriophage and its formation of membrane lethal holes. We also discussed the potential of the holin in the control of bacterial infection.

  9. Optical tweezers studies of viral DNA packaging: Motor function and DNA confinement in Bacteriophages phi29, lambda, and T4

    Science.gov (United States)

    Smith, Douglas

    2007-03-01

    In the assembly of many viruses a powerful molecular motor translocates the genome into a pre-assembled capsid. We use optical tweezers to directly measure translocation of a single DNA molecule into the viral capsid. Improved techniques allow us to measure initiation and early stages of packaging. With phi29 the DNA terminal protein was found to cause large variations in the starting point of packaging. Removal of this protein results in terminal initiation, permitting more accurate assessment of motor function and DNA confinement forces. We investigated the role of electrostatic repulsion by varying ionic screening of the DNA. The observed trends are in accord with those theoretically expected considering counter-ion competition; however the forces are larger than expected in comparison with recent theories and DNA ejection measurements. We have recently succeeded in extending our methods to study two other phages: lambda and T4. These systems have unique structural and functional features, presenting an opportunity for comparative studies in this family of molecular motors. Initial measurements show that lambda and T4 translocate DNA several times faster than the phi29 motor, but are more sensitive to applied load.

  10. Effect of the mutations recB21, recD1013 and recJ284 of Escherichia Coli on the indirect recombinogenesis of the lambda bacteriophage; Efecto de las mutaciones recB21, recD1013 y recJ284 de Escherichia Coli sobre la recombinogenesis indirecta del bacteriofago lambda

    Energy Technology Data Exchange (ETDEWEB)

    Alcantara D, D. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    1994-01-15

    In this report its are related the indirect recombinogenesis of the lambda bacteriophage which depends on it happens in the guest cell after the UV irradiation with those cellular responses to the DNA damages and with the bacterial genes that intervene in them (one of those is the SOS response, controlled by the genes lexA and recA). However it has not been possible to establish a precise relationship among those two phenomena because contradictory results exist. (Author)

  11. Cloning of xylanase gene of Streptomyces flavogriseus in Escherichia coli and bacteriophage lambda-induced lysis for the release of cloned enzyme.

    Science.gov (United States)

    Srivastava, R; Ali, S S; Srivastava, B S

    1991-03-01

    The xylanase gene of Streptomyces flavogriseus was cloned in pUC8 plasmid and expressed in Escherichia coli lysogenic for lambda cI857. lambda-Induced lysis of E. coli at 42 degrees C allowed efficient release of cloned enzyme activity in extracellular environment. The xylanase gene was located in the 0.8-kb HindIII fragment and coded for 18,000 Mr xylanase.

  12. Deletion analysis of the expression of rRNA genes and associated tRNA genes carried by a lambda transducing bacteriophage. [uv radiation, Escherichia coli

    Energy Technology Data Exchange (ETDEWEB)

    Morgan, E.A.; Nomura, M.

    1979-01-01

    Transducing phage lambda ilv5 carries genes for rRNA's, spacer tRNA's (tRNA/sub 1//sup Ile/ and tRNA/sub 1B//sup Ala/), and two other tRNA's (tRNA/sub 1//sup Asp/ and tRNA/sup Trp/). We have isolated a mutant of lambda ilv5, lambda ilv5su7, which carries an amber suppressor mutation in the tRNA/sup Trp/ gene. A series of deletion mutants were isolated from the lambda ilv5su7 phage. Genetic and biochemical analyses of these deletion mutants have confirmed our previous conclusion that the genes for tRNA/sub 1//sup Asp/ and tRNA/sup Trp/ located at the distal end of the rRNA operon (rrnC) are cotranscribed with other rRNA genes in that operon. In addition, these deletions were used to define roughly the physical location of the promoter(s) of the rRNA operon carried by the lambda ilv5su7 transducing phage.

  13. Induction of genetic recombination in the lambda bacteriophage by ultraviolet irradiation of the Escherichia Coli cells. III. Role of the ruvA and recN genes

    International Nuclear Information System (INIS)

    The objective of this work is to determine the paper of the genes ruvA and recN in the stimulation of the recombination of Lambda for UV irradiation of Escherichia Coli, taking into account that both genes are inducible, they belong to the group of genes that participate in the SOS response and that a deficiency in its expression reduces the capacity to repair and recombiner the DNA. (Author)

  14. Effects of recB21, recF143, and uvrD152 on recombination in lambda bacteriophage-prophage and Hfr by F- crosses.

    OpenAIRE

    Howard-Flanders, P; Bardwell, E

    1981-01-01

    The effects of the mutation pairs recB21 recF143 and recB21 uvrD152 on the frequency of genetic recombination were investigated in lambda phage-prophage crosses under homoimmune conditions. To prevent recombinants from being formed by the phage red system, these experiments were performed with phages and prophages carrying red and gam mutations. Both spontaneous and damage-induced recombination was measured, the phages being either undamaged or treated with trimethylpsoralen and 360-nm light ...

  15. Solitons and Collapse in the lambda-repressor protein

    OpenAIRE

    Krokhotin, Andrey; Lundgren, Martin; Niemi, Antti J.

    2012-01-01

    The enterobacteria lambda phage is a paradigm temperate bacteriophage. Its lysogenic and lytic life cycles echo competition between the DNA binding $\\lambda$-repressor (CI) and CRO proteins. Here we scrutinize the structure, stability and folding pathways of the $\\lambda$-repressor protein, that controls the transition from the lysogenic to the lytic state. We first investigate the super-secondary helix-loop-helix composition of its backbone. We use a discrete Frenet framing to resolve the ba...

  16. Campylobacter bacteriophages and bacteriophage therapy.

    Science.gov (United States)

    Connerton, P L; Timms, A R; Connerton, I F

    2011-08-01

    Members of the genus Campylobacter are frequently responsible for human enteric disease with occasionally very serious outcomes. Much of this disease burden is thought to arise from consumption of contaminated poultry products. More than 80% of poultry in the UK harbour Campylobacter as a part of their intestinal flora. To address this unacceptably high prevalence, various interventions have been suggested and evaluated. Among these is the novel approach of using Campylobacter-specific bacteriophages, which are natural predators of the pathogen. To optimize their use as therapeutic agents, it is important to have a comprehensive understanding of the bacteriophages that infect Campylobacter, and how they can affect their host bacteria. This review will focus on many aspects of Campylobacter-specific bacteriophages including: their first isolation in the 1960s, their use in bacteriophage typing schemes, their isolation from the different biological sources and genomic characterization. As well as their use as therapeutic agents to reduce Campylobacter in poultry their future potential, including their use in bio-sanitization of food, will be explored. The evolutionary consequences of naturally occurring bacteriophage infection that have come to light through investigations of bacteriophages in the poultry ecosystem will also be discussed.

  17. Lambda Vision

    Science.gov (United States)

    Czajkowski, Michael

    2014-06-01

    There is an explosion in the quantity and quality of IMINT data being captured in Intelligence Surveillance and Reconnaissance (ISR) today. While automated exploitation techniques involving computer vision are arriving, only a few architectures can manage both the storage and bandwidth of large volumes of IMINT data and also present results to analysts quickly. Lockheed Martin Advanced Technology Laboratories (ATL) has been actively researching in the area of applying Big Data cloud computing techniques to computer vision applications. This paper presents the results of this work in adopting a Lambda Architecture to process and disseminate IMINT data using computer vision algorithms. The approach embodies an end-to-end solution by processing IMINT data from sensors to serving information products quickly to analysts, independent of the size of the data. The solution lies in dividing up the architecture into a speed layer for low-latent processing and a batch layer for higher quality answers at the expense of time, but in a robust and fault-tolerant way. This approach was evaluated using a large corpus of IMINT data collected by a C-130 Shadow Harvest sensor over Afghanistan from 2010 through 2012. The evaluation data corpus included full motion video from both narrow and wide area field-of-views. The evaluation was done on a scaled-out cloud infrastructure that is similar in composition to those found in the Intelligence Community. The paper shows experimental results to prove the scalability of the architecture and precision of its results using a computer vision algorithm designed to identify man-made objects in sparse data terrain.

  18. Induction of genetic recombination in the lambda bacteriophage by ultraviolet irradiation of the Escherichia Coli cells. III. Role of the ruvA and recN genes; Induccion de recombinacion genetica en el bacteriofago lambda por irradiacion ultravioleta de las celulas de Escherichia Coli. III. Papel de los genes ruvA and recN

    Energy Technology Data Exchange (ETDEWEB)

    Alcantara D, D. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    1987-05-15

    The objective of this work is to determine the paper of the genes ruvA and recN in the stimulation of the recombination of Lambda for UV irradiation of Escherichia Coli, taking into account that both genes are inducible, they belong to the group of genes that participate in the SOS response and that a deficiency in its expression reduces the capacity to repair and recombiner the DNA. (Author)

  19. Lambda polarization at HERMES

    Energy Technology Data Exchange (ETDEWEB)

    Belostotski, S. [Petersburg Nuclear Physics Institute RAS Gatchina, Leningrad district 188300 (Russian Federation); Naryshkin, Yu., E-mail: naryshk@mail.desy.d [Petersburg Nuclear Physics Institute RAS Gatchina, Leningrad district 188300 (Russian Federation); Veretennikov, D. [Petersburg Nuclear Physics Institute RAS Gatchina, Leningrad district 188300 (Russian Federation)

    2011-01-15

    Transverse polarization of {Lambda} and {Lambda}-bar hyperons produced inclusively in quasi-real photon-nucleon scattering has been studied for several nuclear targets in a wide range of atomic-mass numbers A. A strong A-dependence of the {Lambda} polarization is observed.

  20. Chlamydia bacteriophages.

    Science.gov (United States)

    Śliwa-Dominiak, Joanna; Suszyńska, Ewa; Pawlikowska, Małgorzata; Deptuła, Wiesław

    2013-11-01

    Phages are called "good viruses" due to their ability to infect and kill pathogenic bacteria. Chlamydia are small, Gram-negative (G-) microbes that can be dangerous to human and animals. In humans, these bacteria are etiological agents of diseases such as psittacosis or respiratory tract diseases, while in animals, the infection may result in enteritis in cattle and chronic bowel diseases, as well as miscarriages in sheep. The first-known representative of chlamydiaphages was Chp1. It was discovered in Chlamydia psittaci isolates. Since then, four more species of chlamydiaphages have been identified [Chp2, Chp3, φCPG1 φCPAR39 (φCpn1) and Chp4]. All of them were shown to infect Chlamydia species. This paper described all known chlamydiaphages. They were characterised in terms of origin, host range, and their molecular structure. The review concerns the characterisation of bacteriophages that infects pathogenic and dangerous bacteria with unusual, intracellular life cycles that are pathogenic. In the era of antibiotic resistance, it is difficult to cure chlamydophilosis. Those bacteriophages can be an alternative to antibiotics, but before this happens, we need to get to know chlamydiaphages better. PMID:23903989

  1. Solitons and Collapse in the lambda-repressor protein

    CERN Document Server

    Krokhotin, Andrey; Niemi, Antti J

    2012-01-01

    The enterobacteria lambda phage is a paradigm temperate bacteriophage. Its lysogenic and lytic life cycles echo competition between the DNA binding $\\lambda$-repressor (CI) and CRO proteins. Here we scrutinize the structure, stability and folding pathways of the $\\lambda$-repressor protein, that controls the transition from the lysogenic to the lytic state. We first investigate the super-secondary helix-loop-helix composition of its backbone. We use a discrete Frenet framing to resolve the backbone spectrum in terms of bond and torsion angles. Instead of four, there appears to be seven individual loops. We model the putative loops using an explicit soliton Ansatz. It is based on the standard soliton profile of the continuum nonlinear Schr\\"odinger equation. The accuracy of the Ansatz far exceeds the B-factor fluctuation distance accuracy of the experimentally determined protein configuration. We then investigate the folding pathways and dynamics of the $\\lambda$-repressor protein. We introduce a coarse-graine...

  2. Insulating behavior of lambda-DNA on the micron scale

    CERN Document Server

    Zhang, Y; Kräft, J; Cox, E C; Ong, N P

    2002-01-01

    We have investigated the electrical conductivity of lambda-DNA using DNA covalently bonded to Au electrodes. Thiol-modified dTTP was incorporated into the `sticky' ends of bacteriophage lambda-DNA using DNA polymerase. Two-probe measurements on such molecules provide a hard lower bound for the resistivity \\rho>10^6 (Ohm cm) at bias potentials up to 20 volts, in conflict with recent claims of moderate to high conductivity. By direct imaging, we show that the molecules are present after the measurements. We stress the importance of eliminating salt residues in these measurements.

  3. Lambda-dropping

    DEFF Research Database (Denmark)

    Danvy, Olivier; Schultz, Ulrik Pagh

    1997-01-01

    ;rbæk's case study presented at PEPM '95, most polyvariant specializers for procedural programs operate on recursive equations. To this end, in a pre-processing phase, they lambda-lift source programs into recursive equations, As a result, residual programs are also expressed as recursive equations, often......Lambda-lifting a functional program transforms it into a set of recursive equations. We present the symmetric transformation: lambda-dropping. Lambda-dropping a set of recursive equations restores block structure and lexical scope.For lack of scope, recursive equations must carry around all...... with dozens of parameters, which most compilers do not handle efficiently. Lambda-dropping in a post-processing phase restores their block structure and lexical scope thereby significantly reducing both the compile time and the run time of residual programs....

  4. The Safe Lambda Calculus

    CERN Document Server

    Blum, William

    2009-01-01

    Safety is a syntactic condition of higher-order grammars that constrains occurrences of variables in the production rules according to their type-theoretic order. In this paper, we introduce the safe lambda calculus, which is obtained by transposing (and generalizing) the safety condition to the setting of the simply-typed lambda calculus. In contrast to the original definition of safety, our calculus does not constrain types (to be homogeneous). We show that in the safe lambda calculus, there is no need to rename bound variables when performing substitution, as variable capture is guaranteed not to happen. We also propose an adequate notion of beta-reduction that preserves safety. In the same vein as Schwichtenberg's 1976 characterization of the simply-typed lambda calculus, we show that the numeric functions representable in the safe lambda calculus are exactly the multivariate polynomials; thus conditional is not definable. We also give a characterization of representable word functions. We then study the ...

  5. Probe $\\Lambda - \\bar{\\Lambda}$ oscillation in $J/\\psi \\rightarrow \\Lambda\\,\\bar\\Lambda$ decay at BES-III

    OpenAIRE

    Kang, X. W.; H.B. Li; Lu, G. R.

    2010-01-01

    We discuss the possible searching for the oscillation by coherent $\\Lambda\\bar{\\Lambda}$ production in $J/\\psi \\rightarrow \\Lambda \\bar{\\Lambda}$ decay process. The sensitivity of measurement of $\\Lambda - \\bar{\\Lambda}$ oscillation in the external field at BES-III experiment is considered. These considerations indicate an alternative way to probe the $\\Delta B =2$ amplitude in addition to neutron oscillation experiments. Both coherent and time-dependent information can be used to extract $\\L...

  6. Comparative genomics of Shiga toxin encoding bacteriophages

    Directory of Open Access Journals (Sweden)

    Smith Darren L

    2012-07-01

    Full Text Available Abstract Background Stx bacteriophages are responsible for driving the dissemination of Stx toxin genes (stx across their bacterial host range. Lysogens carrying Stx phages can cause severe, life-threatening disease and Stx toxin is an integral virulence factor. The Stx-bacteriophage vB_EcoP-24B, commonly referred to as Ф24B, is capable of multiply infecting a single bacterial host cell at a high frequency, with secondary infection increasing the rate at which subsequent bacteriophage infections can occur. This is biologically unusual, therefore determining the genomic content and context of Ф24B compared to other lambdoid Stx phages is important to understanding the factors controlling this phenomenon and determining whether they occur in other Stx phages. Results The genome of the Stx2 encoding phage, Ф24B was sequenced and annotated. The genomic organisation and general features are similar to other sequenced Stx bacteriophages induced from Enterohaemorrhagic Escherichia coli (EHEC, however Ф24B possesses significant regions of heterogeneity, with implications for phage biology and behaviour. The Ф24B genome was compared to other sequenced Stx phages and the archetypal lambdoid phage, lambda, using the Circos genome comparison tool and a PCR-based multi-loci comparison system. Conclusions The data support the hypothesis that Stx phages are mosaic, and recombination events between the host, phages and their remnants within the same infected bacterial cell will continue to drive the evolution of Stx phage variants and the subsequent dissemination of shigatoxigenic potential.

  7. Lambda-Display: A Powerful Tool for Antigen Discovery

    Directory of Open Access Journals (Sweden)

    Nicola Gargano

    2011-04-01

    Full Text Available Since its introduction in 1985, phage display technology has been successfully used in projects aimed at deciphering biological processes and isolating molecules of practical value in several applications. Bacteriophage lambda, representing a classical molecular cloning and expression system has also been exploited for generating large combinatorial libraries of small peptides and protein domains exposed on its capsid. More recently, lambda display has been consistently and successfully employed for domain mapping, antigen discovery and protein interaction studies or, more generally, in functional genomics. We show here the results obtained by the use of large libraries of cDNA and genomic DNA for the molecular dissection of the human B-cell response against complex pathogens, including protozoan parasites, bacteria and viruses. Moreover, by reviewing the experimental work performed in recent investigations we illustrate the potential of lambda display in the diagnostics field and for identifying antigens useful as targets for vaccine development.

  8. Phenomenological Lambda-Nuclear Interactions

    CERN Document Server

    Sinha, R; Taib, B M; Sinha, Rita

    2002-01-01

    Variational Monte Carlo calculations for ${_{\\Lambda}^4}H$ (ground and excited states) and ${_{\\Lambda}^5}He$ are performed to decipher information on ${\\Lambda}$-nuclear interactions. Appropriate operatorial nuclear and ${\\Lambda}$-nuclear correlations have been incorporated to minimize the expectation values of the energies. We use the Argonne $\\upsilon_{18}$ two-body NN along with the Urbana IX three-body NNN interactions. The study demonstrates that a large part of the splitting energy in ${_{\\Lambda}^4}H$ ($0^+-1^+$) is due to the three-body ${\\Lambda}$ NN forces. $_{\\Lambda}^{17}O$ hypernucleus is analyzed using the {\\it s}-shell results. $\\Lambda$ binding to nuclear matter is calculated within the variational framework using the Fermi-Hypernetted-Chain technique. There is a need to correctly incorporate the three-body ${\\Lambda}$ NN correlations for $\\Lambda$ binding to nuclear matter.

  9. $\\Lambda$ Scattering Equations

    CERN Document Server

    Gomez, Humberto

    2016-01-01

    The CHY representation of scattering amplitudes is based on integrals over the moduli space of a punctured sphere. We replace the punctured sphere by a double-cover version. The resulting scattering equations depend on a parameter $\\Lambda$ controlling the opening of a branch cut. The new representation of scattering amplitudes possesses an enhanced redundancy which can be used to fix, modulo branches, the location of four punctures while promoting $\\Lambda$ to a variable. Via residue theorems we show how CHY formulas break up into sums of products of smaller (off-shell) ones times a propagator. This leads to a powerful way of evaluating CHY integrals of generic rational functions, which we call the $\\Lambda$ algorithm.

  10. Bacteriophages Infecting Propionibacterium acnes

    Directory of Open Access Journals (Sweden)

    Holger Brüggemann

    2013-01-01

    Full Text Available Viruses specifically infecting bacteria, or bacteriophages, are the most common biological entity in the biosphere. As such, they greatly influence bacteria, both in terms of enhancing their virulence and in terms of killing them. Since the first identification of bacteriophages in the beginning of the 20th century, researchers have been fascinated by these microorganisms and their ability to eradicate bacteria. In this review, we will cover the history of the Propionibacterium acnes bacteriophage research and point out how bacteriophage research has been an important part of the research on P. acnes itself. We will further discuss recent findings from phage genome sequencing and the identification of phage sequence signatures in clustered regularly interspaced short palindromic repeats (CRISPRs. Finally, the potential to use P. acnes bacteriophages as a therapeutic strategy to combat P. acnes-associated diseases will be discussed.

  11. Bacteriophages infecting Propionibacterium acnes.

    Science.gov (United States)

    Brüggemann, Holger; Lood, Rolf

    2013-01-01

    Viruses specifically infecting bacteria, or bacteriophages, are the most common biological entity in the biosphere. As such, they greatly influence bacteria, both in terms of enhancing their virulence and in terms of killing them. Since the first identification of bacteriophages in the beginning of the 20th century, researchers have been fascinated by these microorganisms and their ability to eradicate bacteria. In this review, we will cover the history of the Propionibacterium acnes bacteriophage research and point out how bacteriophage research has been an important part of the research on P. acnes itself. We will further discuss recent findings from phage genome sequencing and the identification of phage sequence signatures in clustered regularly interspaced short palindromic repeats (CRISPRs). Finally, the potential to use P. acnes bacteriophages as a therapeutic strategy to combat P. acnes-associated diseases will be discussed.

  12. Lambda-Lambda interaction from relativistic heavy-ion collisions

    CERN Document Server

    Morita, Kenji; Ohnishi, Akira

    2014-01-01

    We investigate the two-particle intensity correlation function of $\\Lambda$ in relativistic heavy-ion collisions. We find that the behavior of the $\\Lambda\\Lambda$ correlation function at small relative momenta is fairly sensitive to the interaction potential and collective flows. By comparing the results of different source functions and potentials, we explore the effect of intrinsic collective motions on the correlation function. We find that the recent STAR data gives a strong constraint on the scattering length and effective range of $\\Lambda\\Lambda$ interaction as, $-1.8~\\mathrm{fm}^{-1} < 1/a_0 < -0.8~\\mathrm{fm}^{-1}$ and $3.5~\\mathrm{fm} < r_\\mathrm{eff} < 7~\\mathrm{fm}$, respectively. Implication for the signal of existence of $H$-dibaryon is discussed. Comparison with the scattering parameters obtained from the double $\\Lambda$ hypernucleus may reveal in-medium effects in the $\\Lambda\\Lambda$ interaction.

  13. Probe $\\Lambda - \\overline{\\Lambda}$ oscillation in $J/\\psi \\rightarrow \\Lambda\\,\\overline\\Lambda$ decay at BES-III

    CERN Document Server

    Kang, X W; Lu, G R

    2010-01-01

    We discuss the possible searching for the oscillation by coherent $\\Lambda\\overline{\\Lambda}$ production in $J/\\psi \\rightarrow \\Lambda \\overline{\\Lambda}$ decay process. The sensitivity of measurement of $\\Lambda - \\overline{\\Lambda}$ oscillation in the external field at BES-III experiment is considered. These considerations indicate an alternative way to probe the $\\Delta B =2$ amplitude in addition to neutron oscillation experiments. Both coherent and time-dependent information can be used to extract $\\Lambda -\\overline{\\Lambda}$ oscillation parameter. With one year's luminosity at BES-III, we can set an upper limit of $\\delta m < 10^{-15}$ MeV at 90\\% confidence level, corresponding to about $10^{-6}$ s of $\\Lam-\\Lamb$ oscillation time.

  14. On the role of Cro in lambda prophage induction.

    Science.gov (United States)

    Svenningsen, Sine L; Costantino, Nina; Court, Donald L; Adhya, Sankar

    2005-03-22

    The lysogenic state of bacteriophage lambda is exceptionally stable yet the prophage is readily induced in response to DNA damage. This delicate epigenetic switch is believed to be regulated by two proteins; the lysogenic maintenance promoting protein CI and the early lytic protein Cro. First, we confirm, in the native configuration, the previous observation that the DNA loop mediated by oligomerization of CI bound to two distinct operator regions (O(L) and O(R)), increases repression of the early lytic promoters and is important for stable maintenance of lysogeny. Second, we show that the presence of the cro gene might be unimportant for the lysogenic to lytic switch during induction of the lambda prophage. We revisit the idea that Cro's primary role in induction is instead to mediate weak repression of the early lytic promoters. PMID:15728734

  15. Lambda Calculi: A Guide

    Science.gov (United States)

    Hankin, Chris

    One of the universal notions of programming languages is functional abstraction. The methods of Java and the functions defined and used in functional programming languages, such as Haskell, are instances of this general notion. The inspiration for this form of abstraction mechanism comes from Mathematical Logic; notably Church's λ(lambda)-calculi and Schönfinkel's and Curry's Combinatory Logic. A proper study of these foundations leads to a better understanding of some of the fundamental issues in Computer Science.

  16. Use of bacteriophage particles displaying influenza virus hemagglutinin for the detection of hemagglutination-inhibition antibodies.

    Science.gov (United States)

    Domm, William; Brewer, Matthew; Baker, Steven F; Feng, Changyong; Martínez-Sobrido, Luis; Treanor, John; Dewhurst, Stephen

    2014-03-01

    Bacteriophage lambda capsids provide a flexible molecular scaffold that can be engineered to display a wide range of exogenous proteins, including full-length viral glycoproteins produced in eukaryotic cells. One application for such particles lies in the detection of virus-specific antibodies, since they may obviate the need to work with infectious stocks of highly pathogenic or emerging viruses that can pose significant biosafety and biocontainment challenges. Bacteriophage lambda capsids were produced that displayed an insect-cell derived, recombinant H5 influenza virus hemagglutinin (HA) on their surface. The particles agglutinated red blood cells efficiently, in a manner that could be blocked using H5 HA-specific monoclonal antibodies. The particles were then used to develop a modified hemagglutinination-inhibition (HAI) assay, which successfully identified human sera with H5 HA-specific HAI activity. These results demonstrate the utility of HA-displaying bacteriophage capsids for the detection of influenza virus-specific HAI antibodies.

  17. Observation of B+ --> Lambda c+ Lambda c- K+ and B0 --> Lambda c+ Lambda c- K0 decays.

    Science.gov (United States)

    Gabyshev, N; Abe, K; Abe, K; Adachi, I; Aihara, H; Asano, Y; Aulchenko, V; Aushev, T; Bahinipati, S; Bakich, A M; Balagura, V; Barberio, E; Bartel, W; Bay, A; Bedny, I; Bitenc, U; Bizjak, I; Bondar, A; Bozek, A; Bracko, M; Browder, T E; Chen, A; Chen, W T; Cheon, B G; Chistov, R; Choi, Y; Chuvikov, A; Cole, S; Dalseno, J; Danilov, M; Dash, M; Drutskoy, A; Eidelman, S; Garmash, A; Gershon, T; Gokhroo, G; Golob, B; Haba, J; Hayasaka, K; Hayashii, H; Hazumi, M; Hokuue, T; Hoshi, Y; Hou, S; Hou, W-S; Hsiung, Y B; Ikado, K; Imoto, A; Inami, K; Itoh, R; Iwasaki, M; Iwasaki, Y; Kang, J H; Kawasaki, T; Khan, H R; Kichimi, H; Kim, S M; Korpar, S; Krokovny, P; Kulasiri, R; Kuo, C C; Kuzmin, A; Kwon, Y-J; Leder, G; Lesiak, T; Lin, S-W; Liventsev, D; Majumder, G; Matsumoto, T; Mitaroff, W; Miyabayashi, K; Miyata, H; Miyazaki, Y; Mizuk, R; Nakano, E; Nakao, M; Natkaniec, Z; Nishida, S; Ogawa, S; Ohshima, T; Okabe, T; Okuno, S; Olsen, S L; Ozaki, H; Palka, H; Park, C W; Park, K S; Pestotnik, R; Piilonen, L E; Sakai, Y; Sato, N; Satoyama, N; Schietinger, T; Schneider, O; Schwanda, C; Seidl, R; Senyo, K; Sevior, M E; Shapkin, M; Shibuya, H; Somov, A; Soni, N; Stamen, R; Stanic, S; Staric, M; Sumiyoshi, T; Tamai, K; Tamura, N; Tanaka, M; Taylor, G N; Teramoto, Y; Tian, X C; Tsukamoto, T; Uehara, S; Uglov, T; Ueno, K; Uno, S; Urquijo, P; Varner, G; Varvell, K E; Villa, S; Wang, C C; Wang, C H; Watanabe, Y; Won, E; Xie, Q L; Yamaguchi, A; Yamauchi, M; Ying, J; Zhang, Z P

    2006-11-17

    We report the first measurements of the doubly charmed baryonic B decays B --> Lambda c+ Lambda c- K. The B+ --> Lambda c+ Lambda c- K+ decay is observed with a branching fraction of (6.5(-0.9)(+1.0)+/-1.1+/-3.4)x10(-4) and a statistical significance of 15.4sigma. The B0 --> Lambda c+ Lambda c- K0 decay is observed with a branching fraction of (7.9(-2.3)(+2.9)+/-1.2+/-4.1)x10(-4) and a statistical significance of 6.6sigma. The branching fraction errors are statistical, systematic, and the error resulting from the uncertainty of the Lambda c+ --> pK- pi+ decay branching fraction. The analysis is based on 357 fb(-1) of data accumulated at the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+ e- collider. PMID:17155677

  18. Bacteriophages and Biofilms

    Directory of Open Access Journals (Sweden)

    David R. Harper

    2014-06-01

    Full Text Available Biofilms are an extremely common adaptation, allowing bacteria to colonize hostile environments. They present unique problems for antibiotics and biocides, both due to the nature of the extracellular matrix and to the presence within the biofilm of metabolically inactive persister cells. Such chemicals can be highly effective against planktonic bacterial cells, while being essentially ineffective against biofilms. By contrast, bacteriophages seem to have a greater ability to target this common form of bacterial growth. The high numbers of bacteria present within biofilms actually facilitate the action of bacteriophages by allowing rapid and efficient infection of the host and consequent amplification of the bacteriophage. Bacteriophages also have a number of properties that make biofilms susceptible to their action. They are known to produce (or to be able to induce enzymes that degrade the extracellular matrix. They are also able to infect persister cells, remaining dormant within them, but re-activating when they become metabolically active. Some cultured biofilms also seem better able to support the replication of bacteriophages than comparable planktonic systems. It is perhaps unsurprising that bacteriophages, as the natural predators of bacteria, have the ability to target this common form of bacterial life.

  19. Bacteriophages and cancer.

    Science.gov (United States)

    Budynek, Paulina; Dabrowska, Krystyna; Skaradziński, Grzegorz; Górski, Andrzej

    2010-05-01

    Bacteriophages can be used effectively to cure bacterial infections. They are known to be active against bacteria but inactive against eukaryotic cells. Nevertheless, novel observations suggest that phages are not neutral for higher organisms. They can affect physiological and immunological processes which may be crucial to their expected positive effects in therapies. Bacteriophages are a very differentiated group of viruses and at least some of them can influence cancer processes. Phages may also affect the immunological system. In general, they activate the immunological response, for example cytokine secretion. They can also switch the tumor microenvironment to one advantageous for anticancer treatment. On the other hand, bacteriophages are used as a platform for foreign peptides that may induce anticancer effects. As bacterial debris can interfere with bacteriophage activity, phage purification is significant for the final effect of a phage preparation. In this review, results of the influence of bacteriophages on cancer processes are presented which have implications for the perspective application of phage therapy in patients with cancer and the general understanding of the role of bacteriophages in the human organism.

  20. Challenging packaging limits and infectivity of phage {\\lambda}

    CERN Document Server

    Nurmemmedov, Elmar; Medina, Elizabeth; Catalano, Carlos Enrique; Evilevitch, Alex

    2011-01-01

    The terminase motors of bacteriophages have been shown to be among the strongest active machines in the biomolecular world, being able to package several tens of kilobase pairs of viral genome into a capsid within minutes. Yet these motors are hindered at the end of the packaging process by the progressive build-up of a force resisting packaging associated with already packaged DNA. In this experimental work, we raise the issue of what sets the upper limit on the length of the genome that can be packaged by the terminase motor of phage {\\lambda} and still yield infectious virions, and the conditions under which this can be efficiently performed. Using a packaging strategy developed in our laboratory of building phage {\\lambda} from scratch, together with plaque assay monitoring, we have been able to show that the terminase motor of phage {\\lambda} is able to produce infectious particles with up to 110% of the wild-type (WT) {\\lambda}-DNA length. However, the phage production rate, and thus the infectivity, de...

  1. Circularity and Lambda Abstraction

    DEFF Research Database (Denmark)

    Danvy, Olivier; Thiemann, Peter; Zerny, Ian

    2013-01-01

    In this tribute to Doaitse Swierstra, we present the rst transformation between lazy circular programs a la Bird and strict cir- cular programs a la Pettorossi. Circular programs a la Bird rely on lazy recursive binding: they involve circular unknowns and make sense equa- tionally. Circular...... unknowns from what is done to them, which we lambda-abstract with functions. The circular unknowns then become dead variables, which we eliminate. The result is a strict circu- lar program a la Pettorossi. This transformation is reversible: given a strict circular program a la Pettorossi, we introduce...

  2. Effect of Escherichia coli nusG function on lambda N-mediated transcription antitermination.

    OpenAIRE

    Sullivan, S. L.; Ward, D F; Gottesman, M E

    1992-01-01

    The Escherichia coli Nus factors act in conjunction with the bacteriophage lambda N protein to suppress transcription termination on the lambda chromosome. NusA binds both N and RNA polymerase and may also interact with other Nus factors. To search for additional components of the N antitermination system, we isolated host revertants that restored N activity in nusA1 mutants. One revertant, nusG4, was mapped to the rif region of the E. coli chromosome and shown to represent a point mutation n...

  3. Solitons and Physics of the Lysogenic to Lytic Transition in Enterobacteria Lambda Phage

    OpenAIRE

    Krokhotine, Andrei; Niemi, Antti J.

    2011-01-01

    The lambda phage is a paradigm temperate bacteriophage. Its lysogenic and lytic life cycles echo competition between the DNA binding CI and CRO proteins. Here we address the Physics of this transition in terms of an energy function that portrays the backbone as a multi-soliton configuration. The precision of the individual solitons far exceeds the B-factor accuracy of the experimentally determined protein conformations giving us confidence to conclude that three of the four loops are each com...

  4. Longitudinal {lambda} and anti {lambda} polarization at the COMPASS experiment

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Donghee

    2007-09-15

    At the COMPASS experiment at CERN {lambda} and anti {lambda} particles are produced in deep inelastic scattering (DIS) processes with high statistics. The main focus of the research is the understanding of the spin transfer mechanism from quarks to hadrons through the fragmentation process by utilizing the longitudinal {lambda} and anti {lambda} polarization. The result of the spin transfer provides useful information to test different model predictions which describe spin effects in hyperon production and the quark-antiquark asymmetry of the nucleon and hyperon. The {lambda} and anti {lambda} polarization are determined by measuring the acceptance corrected angular distribution of its decay products. A Monte Carlo simulation is used to correct the acceptance of the COMPASS spectrometer. In this work, preliminary results from data collected in the current fragmentation region during 2002-2004 are presented. A significantly positive average spin transfer of anti {lambda} is found to be equal to C{sub LL}=+0.232{+-}0.039(stat.){+-}0.022(sys.), while the spin transfer of lambda is compatible with zero within the statistical accuracy. The dependences of the spin transfer on various kinematic variables are also presented. (orig.)

  5. Bacteriophage therapy against Enterobacteriaceae

    Institute of Scientific and Technical Information of China (English)

    Youqiang; Xu; Yong; Liu; Yang; Liu; Jiangsen; Pei; Su; Yao; Chi; Cheng

    2015-01-01

    The Enterobacteriaceae are a class of gram-negative facultative anaerobic rods, which can cause a variety of diseases, such as bacteremia, septic arthritis, endocarditis, osteomyelitis, lower respiratory tract infections, skin and soft-tissue infections, urinary tract infections, intra-abdominal infections and ophthalmic infections, in humans, poultry, animals and fish. Disease caused by Enterobacteriaceae cause the deaths of millions of people every year, resulting in enormous economic loss. Drug treatment is a useful and efficient way to control Enterobacteriaceae infections. However, with the abuse of antibiotics, drug resistance has been found in growing number of Enterobacteriaceae infections and, as such, there is an urgent need to find new methods of control. Bacteriophage therapy is an efficient alternative to antibiotics as it employs a different antibacterial mechanism. This paper summarizes the history of bacteriophage therapy, its bacteriallytic mechanisms, and the studies that have focused on Enterobacteriaceae and bacteriophage therapy.

  6. Hyperexpansion of RNA Bacteriophage Diversity

    Science.gov (United States)

    Krishnamurthy, Siddharth R.; Janowski, Andrew B.; Zhao, Guoyan; Barouch, Dan; Wang, David

    2016-01-01

    Bacteriophage modulation of microbial populations impacts critical processes in ocean, soil, and animal ecosystems. However, the role of bacteriophages with RNA genomes (RNA bacteriophages) in these processes is poorly understood, in part because of the limited number of known RNA bacteriophage species. Here, we identify partial genome sequences of 122 RNA bacteriophage phylotypes that are highly divergent from each other and from previously described RNA bacteriophages. These novel RNA bacteriophage sequences were present in samples collected from a range of ecological niches worldwide, including invertebrates and extreme microbial sediment, demonstrating that they are more widely distributed than previously recognized. Genomic analyses of these novel bacteriophages yielded multiple novel genome organizations. Furthermore, one RNA bacteriophage was detected in the transcriptome of a pure culture of Streptomyces avermitilis, suggesting for the first time that the known tropism of RNA bacteriophages may include gram-positive bacteria. Finally, reverse transcription PCR (RT-PCR)-based screening for two specific RNA bacteriophages in stool samples from a longitudinal cohort of macaques suggested that they are generally acutely present rather than persistent. PMID:27010970

  7. Hyperexpansion of RNA Bacteriophage Diversity.

    Directory of Open Access Journals (Sweden)

    Siddharth R Krishnamurthy

    2016-03-01

    Full Text Available Bacteriophage modulation of microbial populations impacts critical processes in ocean, soil, and animal ecosystems. However, the role of bacteriophages with RNA genomes (RNA bacteriophages in these processes is poorly understood, in part because of the limited number of known RNA bacteriophage species. Here, we identify partial genome sequences of 122 RNA bacteriophage phylotypes that are highly divergent from each other and from previously described RNA bacteriophages. These novel RNA bacteriophage sequences were present in samples collected from a range of ecological niches worldwide, including invertebrates and extreme microbial sediment, demonstrating that they are more widely distributed than previously recognized. Genomic analyses of these novel bacteriophages yielded multiple novel genome organizations. Furthermore, one RNA bacteriophage was detected in the transcriptome of a pure culture of Streptomyces avermitilis, suggesting for the first time that the known tropism of RNA bacteriophages may include gram-positive bacteria. Finally, reverse transcription PCR (RT-PCR-based screening for two specific RNA bacteriophages in stool samples from a longitudinal cohort of macaques suggested that they are generally acutely present rather than persistent.

  8. Hyperexpansion of RNA Bacteriophage Diversity.

    Science.gov (United States)

    Krishnamurthy, Siddharth R; Janowski, Andrew B; Zhao, Guoyan; Barouch, Dan; Wang, David

    2016-03-01

    Bacteriophage modulation of microbial populations impacts critical processes in ocean, soil, and animal ecosystems. However, the role of bacteriophages with RNA genomes (RNA bacteriophages) in these processes is poorly understood, in part because of the limited number of known RNA bacteriophage species. Here, we identify partial genome sequences of 122 RNA bacteriophage phylotypes that are highly divergent from each other and from previously described RNA bacteriophages. These novel RNA bacteriophage sequences were present in samples collected from a range of ecological niches worldwide, including invertebrates and extreme microbial sediment, demonstrating that they are more widely distributed than previously recognized. Genomic analyses of these novel bacteriophages yielded multiple novel genome organizations. Furthermore, one RNA bacteriophage was detected in the transcriptome of a pure culture of Streptomyces avermitilis, suggesting for the first time that the known tropism of RNA bacteriophages may include gram-positive bacteria. Finally, reverse transcription PCR (RT-PCR)-based screening for two specific RNA bacteriophages in stool samples from a longitudinal cohort of macaques suggested that they are generally acutely present rather than persistent.

  9. The nucleotide sequence of the bacteriophage T5 ltf gene.

    Science.gov (United States)

    Kaliman, A V; Kulshin, V E; Shlyapnikov, M G; Ksenzenko, V N; Kryukov, V M

    1995-06-01

    The nucleotide sequence of the bacteriophage T5 Bg/II-BamHI fragment (4,835 bp in length) known to carry a gene encoding the LTF protein which forms the phage L-shaped tail fibers was determined. It was shown to contain an open reading frame for 1,396 amino acid residues that corresponds to a protein of 147.8 kDa. The coding region of ltf gene is preceded by a typical Shine-Dalgarno sequence. Downstream from the ltf gene there is a strong transcription terminator. Data bank analysis of the LTF protein sequence reveals 55.1% identity to the hypothetical protein ORF 401 of bacteriophage lambda in a segment of 118 amino acids overlap. PMID:7789514

  10. Search for the $\\Lambda_b^0 \\rightarrow \\Lambda \\eta^\\prime$ and $\\Lambda_b^0\\rightarrow \\Lambda \\eta$ decays with the LHCb detector

    CERN Document Server

    Aaij, Roel; Adinolfi, Marco; Affolder, Anthony; Ajaltouni, Ziad; Akar, Simon; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio Augusto; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; An, Liupan; Anderlini, Lucio; Anderson, Jonathan; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Aquines Gutierrez, Osvaldo; Archilli, Flavio; d'Argent, Philippe; Artamonov, Alexander; Artuso, Marina; Aslanides, Elie; Auriemma, Giulio; Baalouch, Marouen; Bachmann, Sebastian; Back, John; Badalov, Alexey; Baesso, Clarissa; Baldini, Wander; Barlow, Roger; Barschel, Colin; Barsuk, Sergey; Barter, William; Batozskaya, Varvara; Battista, Vincenzo; Bay, Aurelio; Beaucourt, Leo; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Bel, Lennaert; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Benton, Jack; Berezhnoy, Alexander; Bernet, Roland; Bertolin, Alessandro; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bien, Alexander; Bifani, Simone; Bird, Thomas; Birnkraut, Alex; Bizzeti, Andrea; Blake, Thomas; Blanc, Frédéric; Blouw, Johan; Blusk, Steven; Bocci, Valerio; Bondar, Alexander; Bondar, Nikolay; Bonivento, Walter; Borghi, Silvia; Borsato, Martino; Bowcock, Themistocles; Bowen, Espen Eie; Bozzi, Concezio; Braun, Svende; Brett, David; Britsch, Markward; Britton, Thomas; Brodzicka, Jolanta; Brook, Nicholas; Bursche, Albert; Buytaert, Jan; Cadeddu, Sandro; Calabrese, Roberto; Calvi, Marta; Calvo Gomez, Miriam; Campana, Pierluigi; Campora Perez, Daniel; Capriotti, Lorenzo; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carniti, Paolo; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casanova Mohr, Raimon; Casse, Gianluigi; Cassina, Lorenzo; Castillo Garcia, Lucia; Cattaneo, Marco; Cauet, Christophe; Cavallero, Giovanni; Cenci, Riccardo; Charles, Matthew; Charpentier, Philippe; Chefdeville, Maximilien; Chen, Shanzhen; Cheung, Shu-Faye; Chiapolini, Nicola; Chrzaszcz, Marcin; Cid Vidal, Xabier; Ciezarek, Gregory; Clarke, Peter; Clemencic, Marco; Cliff, Harry; Closier, Joel; Coco, Victor; Cogan, Julien; Cogneras, Eric; Cogoni, Violetta; Cojocariu, Lucian; Collazuol, Gianmaria; Collins, Paula; Comerma-Montells, Albert; Contu, Andrea; Cook, Andrew; Coombes, Matthew; Coquereau, Samuel; Corti, Gloria; Corvo, Marco; Couturier, Benjamin; Cowan, Greig; Craik, Daniel Charles; Crocombe, Andrew; Cruz Torres, Melissa Maria; Cunliffe, Samuel; Currie, Robert; D'Ambrosio, Carmelo; Dalseno, Jeremy; David, Pieter; Davis, Adam; De Bruyn, Kristof; De Capua, Stefano; De Cian, Michel; De Miranda, Jussara; De Paula, Leandro; De Silva, Weeraddana; De Simone, Patrizia; Dean, Cameron Thomas; Decamp, Daniel; Deckenhoff, Mirko; Del Buono, Luigi; Déléage, Nicolas; Derkach, Denis; Deschamps, Olivier; Dettori, Francesco; Dey, Biplab; Di Canto, Angelo; Di Ruscio, Francesco; Dijkstra, Hans; Donleavy, Stephanie; Dordei, Francesca; Dorigo, Mirco; Dosil Suárez, Alvaro; Dossett, David; Dovbnya, Anatoliy; Dreimanis, Karlis; Dufour, Laurent; Dujany, Giulio; Dupertuis, Frederic; Durante, Paolo; Dzhelyadin, Rustem; Dziurda, Agnieszka; Dzyuba, Alexey; Easo, Sajan; Egede, Ulrik; Egorychev, Victor; Eidelman, Semen; Eisenhardt, Stephan; Eitschberger, Ulrich; Ekelhof, Robert; Eklund, Lars; El Rifai, Ibrahim; Elsasser, Christian; Ely, Scott; Esen, Sevda; Evans, Hannah Mary; Evans, Timothy; Falabella, Antonio; Färber, Christian; Farinelli, Chiara; Farley, Nathanael; Farry, Stephen; Fay, Robert; Ferguson, Dianne; Fernandez Albor, Victor; Ferrari, Fabio; Ferreira Rodrigues, Fernando; Ferro-Luzzi, Massimiliano; Filippov, Sergey; Fiore, Marco; Fiorini, Massimiliano; Firlej, Miroslaw; Fitzpatrick, Conor; Fiutowski, Tomasz; Fohl, Klaus; Fol, Philip; Fontana, Marianna; Fontanelli, Flavio; Forty, Roger; Francisco, Oscar; Frank, Markus; Frei, Christoph; Frosini, Maddalena; Fu, Jinlin; Furfaro, Emiliano; Gallas Torreira, Abraham; Galli, Domenico; Gallorini, Stefano; Gambetta, Silvia; Gandelman, Miriam; Gandini, Paolo; Gao, Yuanning; García Pardiñas, Julián; Garofoli, Justin; Garra Tico, Jordi; Garrido, Lluis; Gascon, David; Gaspar, Clara; Gastaldi, Ugo; Gauld, Rhorry; Gavardi, Laura; Gazzoni, Giulio; Geraci, Angelo; Gerick, David; Gersabeck, Evelina; Gersabeck, Marco; Gershon, Timothy; Ghez, Philippe; Gianelle, Alessio; Gianì, Sebastiana; Gibson, Valerie; Girard, Olivier Göran; Giubega, Lavinia-Helena; Gligorov, Vladimir; Göbel, Carla; Golubkov, Dmitry; Golutvin, Andrey; Gomes, Alvaro; Gotti, Claudio; Grabalosa Gándara, Marc; Graciani Diaz, Ricardo; Granado Cardoso, Luis Alberto; Graugés, Eugeni; Graverini, Elena; Graziani, Giacomo; Grecu, Alexandru; Greening, Edward; Gregson, Sam; Griffith, Peter; Grillo, Lucia; Grünberg, Oliver; Gui, Bin; Gushchin, Evgeny; Guz, Yury; Gys, Thierry; Hadjivasiliou, Christos; Haefeli, Guido; Haen, Christophe; Haines, Susan; Hall, Samuel; Hamilton, Brian; Hampson, Thomas; Han, Xiaoxue; Hansmann-Menzemer, Stephanie; Harnew, Neville; Harnew, Samuel; Harrison, Jonathan; He, Jibo; Head, Timothy; Heijne, Veerle; Hennessy, Karol; Henrard, Pierre; Henry, Louis; Hernando Morata, Jose Angel; van Herwijnen, Eric; Heß, Miriam; Hicheur, Adlène; Hill, Donal; Hoballah, Mostafa; Hombach, Christoph; Hulsbergen, Wouter; Humair, Thibaud; Hussain, Nazim; Hutchcroft, David; Hynds, Daniel; Idzik, Marek; Ilten, Philip; Jacobsson, Richard; Jaeger, Andreas; Jalocha, Pawel; Jans, Eddy; Jawahery, Abolhassan; Jing, Fanfan; John, Malcolm; Johnson, Daniel; Jones, Christopher; Joram, Christian; Jost, Beat; Jurik, Nathan; Kandybei, Sergii; Kanso, Walaa; Karacson, Matthias; Karbach, Moritz; Karodia, Sarah; Kelsey, Matthew; Kenyon, Ian; Kenzie, Matthew; Ketel, Tjeerd; Khanji, Basem; Khurewathanakul, Chitsanu; Klaver, Suzanne; Klimaszewski, Konrad; Kochebina, Olga; Kolpin, Michael; Komarov, Ilya; Koopman, Rose; Koppenburg, Patrick; Korolev, Mikhail; Kravchuk, Leonid; Kreplin, Katharina; Kreps, Michal; Krocker, Georg; Krokovny, Pavel; Kruse, Florian; Kucewicz, Wojciech; Kucharczyk, Marcin; Kudryavtsev, Vasily; Kuonen, Axel Kevin; Kurek, Krzysztof; Kvaratskheliya, Tengiz; La Thi, Viet Nga; Lacarrere, Daniel; Lafferty, George; Lai, Adriano; Lambert, Dean; Lambert, Robert W; Lanfranchi, Gaia; Langenbruch, Christoph; Langhans, Benedikt; Latham, Thomas; Lazzeroni, Cristina; Le Gac, Renaud; van Leerdam, Jeroen; Lees, Jean-Pierre; Lefèvre, Regis; Leflat, Alexander; Lefrançois, Jacques; Leroy, Olivier; Lesiak, Tadeusz; Leverington, Blake; Li, Yiming; Likhomanenko, Tatiana; Liles, Myfanwy; Lindner, Rolf; Linn, Christian; Lionetto, Federica; Liu, Bo; Liu, Xuesong; Lohn, Stefan; Longstaff, Iain; Lopes, Jose; Lucchesi, Donatella; Lucio Martinez, Miriam; Luo, Haofei; Lupato, Anna; Luppi, Eleonora; Lupton, Oliver; Machefert, Frederic; Maciuc, Florin; Maev, Oleg; Maguire, Kevin; Malde, Sneha; Malinin, Alexander; Manca, Giulia; Mancinelli, Giampiero; Manning, Peter Michael; Mapelli, Alessandro; Maratas, Jan; Marchand, Jean François; Marconi, Umberto; Marin Benito, Carla; Marino, Pietro; Märki, Raphael; Marks, Jörg; Martellotti, Giuseppe; Martinelli, Maurizio; Martinez Santos, Diego; Martinez Vidal, Fernando; Martins Tostes, Danielle; Massafferri, André; Matev, Rosen; Mathad, Abhijit; Mathe, Zoltan; Matteuzzi, Clara; Matthieu, Kecke; Mauri, Andrea; Maurin, Brice; Mazurov, Alexander; McCann, Michael; McCarthy, James; McNab, Andrew; McNulty, Ronan; Meadows, Brian; Meier, Frank; Meissner, Marco; Merk, Marcel; Milanes, Diego Alejandro; Minard, Marie-Noelle; Mitzel, Dominik Stefan; Molina Rodriguez, Josue; Monteil, Stephane; Morandin, Mauro; Morawski, Piotr; Mordà, Alessandro; Morello, Michael Joseph; Moron, Jakub; Morris, Adam Benjamin; Mountain, Raymond; Muheim, Franz; Müller, Janine; Müller, Katharina; Müller, Vanessa; Mussini, Manuel; Muster, Bastien; Naik, Paras; Nakada, Tatsuya; Nandakumar, Raja; Nasteva, Irina; Needham, Matthew; Neri, Nicola; Neubert, Sebastian; Neufeld, Niko; Neuner, Max; Nguyen, Anh Duc; Nguyen, Thi-Dung; Nguyen-Mau, Chung; Niess, Valentin; Niet, Ramon; Nikitin, Nikolay; Nikodem, Thomas; Ninci, Daniele; Novoselov, Alexey; O'Hanlon, Daniel Patrick; Oblakowska-Mucha, Agnieszka; Obraztsov, Vladimir; Ogilvy, Stephen; Okhrimenko, Oleksandr; Oldeman, Rudolf; Onderwater, Gerco; Osorio Rodrigues, Bruno; Otalora Goicochea, Juan Martin; Otto, Adam; Owen, Patrick; Oyanguren, Maria Aranzazu; Palano, Antimo; Palombo, Fernando; Palutan, Matteo; Panman, Jacob; Papanestis, Antonios; Pappagallo, Marco; Pappalardo, Luciano; Parkes, Christopher; Passaleva, Giovanni; Patel, Girish; Patel, Mitesh; Patrignani, Claudia; Pearce, Alex; Pellegrino, Antonio; Penso, Gianni; Pepe Altarelli, Monica; Perazzini, Stefano; Perret, Pascal; Pescatore, Luca; Petridis, Konstantinos; Petrolini, Alessandro; Petruzzo, Marco; Picatoste Olloqui, Eduardo; Pietrzyk, Boleslaw; Pilař, Tomas; Pinci, Davide; Pistone, Alessandro; Piucci, Alessio; Playfer, Stephen; Plo Casasus, Maximo; Poikela, Tuomas; Polci, Francesco; Poluektov, Anton; Polyakov, Ivan; Polycarpo, Erica; Popov, Alexander; Popov, Dmitry; Popovici, Bogdan; Potterat, Cédric; Price, Eugenia; Price, Joseph David; Prisciandaro, Jessica; Pritchard, Adrian; Prouve, Claire; Pugatch, Valery; Puig Navarro, Albert; Punzi, Giovanni; Qian, Wenbin; Quagliani, Renato; Rachwal, Bartolomiej; Rademacker, Jonas; Rakotomiaramanana, Barinjaka; Rama, Matteo; Rangel, Murilo; Raniuk, Iurii; Rauschmayr, Nathalie; Raven, Gerhard; Redi, Federico; Reichert, Stefanie; Reid, Matthew; dos Reis, Alberto; Ricciardi, Stefania; Richards, Sophie; Rihl, Mariana; Rinnert, Kurt; Rives Molina, Vincente; Robbe, Patrick; Rodrigues, Ana Barbara; Rodrigues, Eduardo; Rodriguez Lopez, Jairo Alexis; Rodriguez Perez, Pablo; Roiser, Stefan; Romanovsky, Vladimir; Romero Vidal, Antonio; Rotondo, Marcello; Rouvinet, Julien; Ruf, Thomas; Ruiz, Hugo; Ruiz Valls, Pablo; Saborido Silva, Juan Jose; Sagidova, Naylya; Sail, Paul; Saitta, Biagio; Salustino Guimaraes, Valdir; Sanchez Mayordomo, Carlos; Sanmartin Sedes, Brais; Santacesaria, Roberta; Santamarina Rios, Cibran; Santimaria, Marco; Santovetti, Emanuele; Sarti, Alessio; Satriano, Celestina; Satta, Alessia; Saunders, Daniel Martin; Savrina, Darya; Schiller, Manuel; Schindler, Heinrich; Schlupp, Maximilian; Schmelling, Michael; Schmelzer, Timon; Schmidt, Burkhard; Schneider, Olivier; Schopper, Andreas; Schubiger, Maxime; Schune, Marie Helene; Schwemmer, Rainer; Sciascia, Barbara; Sciubba, Adalberto; Semennikov, Alexander; Sepp, Indrek; Serra, Nicola; Serrano, Justine; Sestini, Lorenzo; Seyfert, Paul; Shapkin, Mikhail; Shapoval, Illya; Shcheglov, Yury; Shears, Tara; Shekhtman, Lev; Shevchenko, Vladimir; Shires, Alexander; Silva Coutinho, Rafael; Simi, Gabriele; Sirendi, Marek; Skidmore, Nicola; Skillicorn, Ian; Skwarnicki, Tomasz; Smith, Edmund; Smith, Eluned; Smith, Iwan Thomas; Smith, Jackson; Smith, Mark; Snoek, Hella; Sokoloff, Michael; Soler, Paul; Soomro, Fatima; Souza, Daniel; Souza De Paula, Bruno; Spaan, Bernhard; Spradlin, Patrick; Sridharan, Srikanth; Stagni, Federico; Stahl, Marian; Stahl, Sascha; Steinkamp, Olaf; Stenyakin, Oleg; Sterpka, Christopher Francis; Stevenson, Scott; Stoica, Sabin; Stone, Sheldon; Storaci, Barbara; Stracka, Simone; Straticiuc, Mihai; Straumann, Ulrich; Sun, Liang; Sutcliffe, William; Swientek, Krzysztof; Swientek, Stefan; Syropoulos, Vasileios; Szczekowski, Marek; Szczypka, Paul; Szumlak, Tomasz; T'Jampens, Stephane; Tekampe, Tobias; Teklishyn, Maksym; Tellarini, Giulia; Teubert, Frederic; Thomas, Christopher; Thomas, Eric; van Tilburg, Jeroen; Tisserand, Vincent; Tobin, Mark; Todd, Jacob; Tolk, Siim; Tomassetti, Luca; Tonelli, Diego; Topp-Joergensen, Stig; Torr, Nicholas; Tournefier, Edwige; Tourneur, Stephane; Trabelsi, Karim; Tran, Minh Tâm; Tresch, Marco; Trisovic, Ana; Tsaregorodtsev, Andrei; Tsopelas, Panagiotis; Tuning, Niels; Ukleja, Artur; Ustyuzhanin, Andrey; Uwer, Ulrich; Vacca, Claudia; Vagnoni, Vincenzo; Valenti, Giovanni; Vallier, Alexis; Vazquez Gomez, Ricardo; Vazquez Regueiro, Pablo; Vázquez Sierra, Carlos; Vecchi, Stefania; Velthuis, Jaap; Veltri, Michele; Veneziano, Giovanni; Vesterinen, Mika; Viaud, Benoit; Vieira, Daniel; Vieites Diaz, Maria; Vilasis-Cardona, Xavier; Vollhardt, Achim; Volyanskyy, Dmytro; Voong, David; Vorobyev, Alexey; Vorobyev, Vitaly; Voß, Christian; de Vries, Jacco; Waldi, Roland; Wallace, Charlotte; Wallace, Ronan; Walsh, John; Wandernoth, Sebastian; Wang, Jianchun; Ward, David; Watson, Nigel; Websdale, David; Weiden, Andreas; Whitehead, Mark; Wiedner, Dirk; Wilkinson, Guy; Wilkinson, Michael; Williams, Mark Richard James; Williams, Matthew; Williams, Mike; Williams, Timothy; Wilson, Fergus; Wimberley, Jack; Wishahi, Julian; Wislicki, Wojciech; Witek, Mariusz; Wormser, Guy; Wotton, Stephen; Wright, Simon; Wyllie, Kenneth; Xie, Yuehong; Xu, Zhirui; Yang, Zhenwei; Yu, Jiesheng; Yuan, Xuhao; Yushchenko, Oleg; Zangoli, Maria; Zavertyaev, Mikhail; Zhang, Liming; Zhang, Yanxi; Zhelezov, Alexey; Zhokhov, Anatoly; Zhong, Liang

    2015-01-01

    A search is performed for the as yet unobserved baryonic $\\Lambda_b^0 \\rightarrow \\Lambda \\eta^\\prime$ and $\\Lambda_b^0 \\rightarrow \\Lambda \\eta$ decays with 3$fb^{-1}$ of proton-proton collision data recorded by the LHCb experiment. The $B^0 \\rightarrow K_S^0 \\eta^\\prime$ decay is used as a normalisation channel. No significant signal is observed for the $\\Lambda_b^0 \\rightarrow \\Lambda \\eta^\\prime$ decay. An upper limit is found on the branching fraction of $\\mathcal{B}(\\Lambda_b^0 \\rightarrow \\Lambda \\eta^\\prime)<3.1\\times10^{-6}$ at 90% confidence level. Evidence is seen for the presence of the $\\Lambda_b^0 \\rightarrow \\Lambda \\eta$ decay at the level of $3\\sigma$ significance, with a branching fraction $\\mathcal{B}(\\Lambda_b^0 \\rightarrow \\Lambda \\eta)=(9.3^{+7.3}_{-5.3})\\times10^{-6}$.

  11. Chlamydial plasmids and bacteriophages.

    Science.gov (United States)

    Pawlikowska-Warych, Małgorzata; Śliwa-Dominiak, Joanna; Deptuła, Wiesław

    2015-01-01

    Chlamydia are absolute pathogens of humans and animals; despite being rather well recognised, they are still open for discovery. One such discovery is the occurrence of extrachromosomal carriers of genetic information. In prokaryotes, such carriers include plasmids and bacteriophages, which are present only among some Chlamydia species. Plasmids were found exclusively in Chlamydia (C.) trachomatis, C. psittaci, C. pneumoniae, C. suis, C. felis, C. muridarum and C. caviae. In prokaryotic organisms, plasmids usually code for genes that facilitate survival of the bacteria in the environment (although they are not essential). In chlamydia, their role has not been definitely recognised, apart from the fact that they participate in the synthesis of glycogen and encode proteins responsible for their virulence. Furthermore, in C. suis it was evidenced that the plasmid is integrated in a genomic island and contains the tetracycline-resistance gene. Bacteriophages specific for chlamydia (chlamydiaphages) were detected only in six species: C. psittaci, C. abortus, C. felis, C. caviae C. pecorum and C. pneumoniae. These chlamydiaphages cause inhibition of the developmental cycle, and delay transformation of reticulate bodies (RBs) into elementary bodies (EBs), thus reducing the possibility of infecting other cells in time. Plasmids and bacteriophages can be used in the diagnostics of chlamydioses; although especially in the case of plasmids, they are already used for detection of chlamydial infections. In addition, bacteriophages could be used as therapeutic agents to replace antibiotics, potentially addressing the problem of increasing antibiotic-resistance among chlamydia.

  12. Involvement of colicin in the limited protection of the colicin producing cells against bacteriophage.

    Science.gov (United States)

    Lin, Yu-Hui; Liao, Chen-Chung; Liang, Po-Huang; Yuan, Hanna S; Chak, Kin-Fu

    2004-05-21

    The restriction/modification system is considered to be the most common machinery of microorganisms for protection against bacteriophage infection. However, we found that mitomycin C induced Escherichia coli containing ColE7-K317 can confer limited protection against bacteriophage M13K07 and lambda infection. Our study showed that degree of protection is correlated with the expression level of the ColE7 operon, indicating that colicin E7 alone or the colicin E7-immunity protein complex is directly involved in this protection mechanism. It was also noted that the degree of protection is greater against the single-strand DNA bacteriophage M13K07 than the double-strand bacteriophage(lambda). Coincidently, the K(A) value of ColE7-Im either interacting with single-strand DNA (2.94x10(5)M(-1)) or double-strand DNA (1.75x10(5)M(-1)) reveals that the binding affinity of ColE7-Im with ssDNA is 1.68-fold stronger than that of the protein complex interacting with dsDNA. Interaction between colicin and the DNA may play a central role in this limited protection of the colicin-producing cell against bacteriophages. Based on these observations, we suggest that the colicin exporting pathway may interact to some extent with the bacteriophage infection pathway leading to a limited selective advantage for and limited protection of colicin-producing cells against different bacteriophages. PMID:15110756

  13. What if $\\lambda_{hhh}\

    CERN Document Server

    Efrati, Aielet

    2014-01-01

    A measurement of the Higgs trilinear self coupling $\\lambda_{hhh}$ will test the Standard Model Higgs potential. But can it reveal information that cannot be learned otherwise? By analyzing several simple extensions of the Standard Model scalar sector we show that this measurement might give a first hint for New Physics modifying the electroweak symmetry breaking. Combining the measurements of $\\lambda_{hhh}$ and $\\lambda_{hVV}$ ($V=W,Z$) is particularly powerful in distinguishing between various models of New Physics and in providing unique information on these models.

  14. Scalar Lambda N and Lambda Lambda interaction in a chiral unitary approach

    CERN Document Server

    Sasaki, K; Vacas, M J V

    2006-01-01

    We study the central part of Lambda N and Lambda Lambda potential by considering the correlated and uncorrelated two-meson exchange besides the omega exchange contribution. The correlated two-meson is evaluated in a chiral unitary approach. We find that a short range repulsion is generated by the correlated two-meson potential which also produces an attraction in the intermediate distance region. The uncorrelated two-meson exchange produces a sizeable attraction in all cases which is counterbalanced by omega exchange contribution.

  15. Isolation of Escherichia coli rpoB mutants resistant to killing by lambda cII protein and altered in pyrE gene attenuation

    DEFF Research Database (Denmark)

    Hammer, Karin; Jensen, Kaj Frank; Poulsen, Peter;

    1987-01-01

    Escherichia coli mutants simultaneously resistant to rifampin and to the lethal effects of bacteriophage lambda cII protein were isolated. The sck mutant strains carry alterations in rpoB that allow them to survive cII killing (thus the name sck), but that do not impair either the expression of c...

  16. Lambda polarization in association K+ -Lambda electro-production

    CERN Document Server

    Teodorescu, L; Angelescu, T; Baker, O K; Ent, R; Guidal, M; Laget, J M; Mitchell, J; Niculescu, G; Vanderhaeghen, V; William, R

    1999-01-01

    The result of a feasibility study to measure the Lambda polarization in associated K+ -Lambda electro production is presented. This measurement was performed in the experimental Hall C at Jefferson Lab. The scattered electron was detected in the HMS spectrometer, and the electro-produced kaon and the proton from the Lambda -> ppi- decay were both detected in the SOS spectrometer. This quantity is very sensitive to the elementary p(e,e'K) [capital Lambda, Greek] process and gives information on resonance production, and Regge exchange, among others. The result presented was measured at Q2=1.50 (GeV/c)2 and cos [straight theta, small theta, Greek] K [small gamma, Greek] CM=14 sup o. The limits of the [capital Lambda, Greek] polarization, with respect to the p [small gamma, Greek] x pK axis, were found to be -0.21 and +0.89 with a confidence level of 68%. The result is compared to theoretical predictions based on an effective hadronic field Lagrangian model and a Regge framework model.

  17. DNA ejection from bacteriophage: towards a general behavior for osmotic suppression experiments

    CERN Document Server

    Castelnovo, Martin

    2007-01-01

    We present in this work in vitro measurements of the force ejecting DNA from two distinct bacteriophages (T5 and lambda) using the smotic-suppression technique. Our data are analyzed by revisiting the current theories of DNA packaging in spherical capsids. In particular we show that a simplified analytical model based on bending considerations only is able to account quantitatively for the experimental findings. Physical and biological consequences are discussed.

  18. Expression of the bacteriophage T4 denV structural gene in Escherichia coli

    International Nuclear Information System (INIS)

    The expression of the T4 denV gene, which previously had been cloned in plasmid constructs downstream of the bacteriophage lambda hybrid promoter-operator oLpR, was analyzed under a variety of growth parameters. Expression of the denV gene product, endonuclease V, was confirmed in DNA repair-deficient Escherichia coli (uvrA recA) by Western blot analyses and by enhancements of resistance to UV irradiation

  19. A one-step miniprep for the isolation of plasmid DNA and lambda phage particles.

    Directory of Open Access Journals (Sweden)

    George Lezin

    Full Text Available Plasmid DNA minipreps are fundamental techniques in molecular biology. Current plasmid DNA minipreps use alkali and the anionic detergent SDS in a three-solution format. In addition, alkali minipreps usually require additional column-based purification steps and cannot isolate other extra-chromosomal elements, such as bacteriophages. Non-ionic detergents (NIDs have been used occasionally as components of multiple-solution plasmid DNA minipreps, but a one-step approach has not been developed. Here, we have established a one-tube, one-solution NID plasmid DNA miniprep, and we show that this approach also isolates bacteriophage lambda particles. NID minipreps are more time-efficient than alkali minipreps, and NID plasmid DNA performs better than alkali DNA in many downstream applications. In fact, NID crude lysate DNA is sufficiently pure to be used in digestion and sequencing reactions. Microscopic analysis showed that the NID procedure fragments E. coli cells into small protoplast-like components, which may, at least in part, explain the effectiveness of this approach. This work demonstrates that one-step NID minipreps are a robust method to generate high quality plasmid DNA, and NID approaches can also isolate bacteriophage lambda particles, outperforming current standard alkali-based minipreps.

  20. The Guarded Lambda-Calculus

    DEFF Research Database (Denmark)

    Clouston, Ranald; Bizjak, Aleš; Grathwohl, Hans Bugge;

    2016-01-01

    -former inspired by modal logic and Atkey-McBride clock quantification, allowing the typing of acausal functions. We give a call-by-name operational semantics for the calculus, and define adequate denotational semantics in the topos of trees. The adequacy proof entails that the evaluation of a program always......We present the guarded lambda-calculus, an extension of the simply typed lambda-calculus with guarded recursive and coinductive types. The use of guarded recursive types ensures the productivity of well-typed programs. Guarded recursive types may be transformed into coinductive types by a type...

  1. The algebraic lambda-calculus

    OpenAIRE

    Vaux, Lionel

    2009-01-01

    We introduce an extension of the pure lambda-calculus by endowing the set of terms with a structure of vector space, or more generally of module, over a fixed set of scalars. Terms are moreover subject to identities similar to usual point-wise definition of linear combinations of functions with values in a vector space. We then study a natural extension of beta-reduction in this setting: we prove it is confluent, then discuss consistency and conservativity over the ordinary lambda-calculus. W...

  2. Search for $e^+e^- --> Lambda_b^0 barLambda_b^0 Near Threshold

    CERN Document Server

    Besson, D; Adam, N E; Adams, G S; Alexander, J P; Arms, K; Artuso, M; Athar, S B; Avery, P; Berkelman, K; Blusk, S; Boisvert, V; Bonvicini, G; Bornheim, A; Boulahouache, C; Breva-Newell, L; Briere, R A; Butt, J; Cassel, D G; Chasse, M; Chen, G P; Cinabro, D; Coan, T E; Cronin-Hennessy, D; Cummings, J P; Csorna, S E; Dambasuren, E; Danko, I; Dorjkhaidav, O; Duboscq, J E; Dubrovin, M; Dytman, S A; Eckhart, E; Ecklund, K M; Edwards, K W; Ehrlich, R; Eisenstein, B I; Ernst, J; Ferguson, T; Galik, R S; Gan, K K; Gao, K Y; Gao, Y S; Gibbons, L; Gittelman, B; Gollin, G D; Gong, D T; Gray, S W; Gwon, C; Hartill, D L; Haynes, J; Hsu, L; Huang, G S; Jones, C D; Kandaswamy, J; Karliner, I; Kreinick, D L; Kubota, Y; Kuznetsov, V E; Li, S Z; Lipeles, E; Liu, F; Lowrey, N; Magerkurth, A; Mahlke-Krüger, H; Mahmood, A H; Mehrabyan, S S; Menaa, N; Metreveli, Z V; Meyer, T O; Miller, D H; Mountain, R; Müller, J A; Muramatsu, H; Naik, P; Nam, S; Nandakumar, R; Napolitano, J; Pappas, S P; Park, C S; Park, W; Patterson, J R; Pavlunin, V; Pedlar, T K; Peterson, D; Pivarski, J; Poling, R A; Potlia, V; Redjimi, R; Riley, D; Sadoff, A J; Sanghi, B; Savinov, V; Schwarthoff, H; Scott, A W; Sedlack, C; Selen, M; Seth, K K; Severini, P; Shapiro, A; Shepherd, M R; Shibata, E I; Shipsey, I P J; Sia, R; Skubic, H; Skwarnicki, T; Smith, A; Stepaniak, C J; Stöck, H; Stone, S; Stroynowski, R; Sun, W M; Tatishvili, G T; Thaler, J J; Thayer, J B; Thayer, J G; Thorndike, E H; Tomaradze, A G; Urheim, J; Urner, D; Vogel, H; Wang, J C; Watkins, M E; Wefindh M,; Weinberger, M; Weinstein, A J; Wilksen, T; Williams, J; Yelton, J; Zweber, P

    2004-01-01

    Using the CLEO III detector at CESR we study e+e- collisions in the center-of-mass energy close to, or above, Lambda_b anti-Lambda_b production threshold. We search for evidence of Lambda_b anti-Lambda_b resonance production and set upper limits based on inclusive hadron production as a barometer of Lambda_b anti-Lambda_b production.

  3. Study of Lambda/c+ Cabibbo Favored Decays Containing a Lambda Baryon in the Final State

    CERN Document Server

    Link, J M; Anjos, J C; Bediaga, I; Castromonte, C; Machado, A A; Magnin, J; Massafferri, A; De Miranda, J M; Pepe, I M; Polycarpo, E; Dos Reis, A C; Carrillo, S; Casimiro, E; Cuautle, E; Sánchez-Hernández, A; Uribe, C; Vázquez, F; Agostino, L; Cinquini, L; Cumalat, J P; O'Reilly, B; Segoni, I; Stenson, K; Butler, J N; Cheung, H W K; Chiodini, G; Gaines, I; Garbincius, P H; Garren, L A; Gottschalk, E; Kasper, P H; Kreymer, A E; Kutschke, R; Wang, M; Benussi, L; Bertani, M; Bianco, S; Fabbri, F L; Pacetti, S; Zallo, A; Reyes, M; Cawlfield, C; Kim, D Y; Rahimi, A; Wiss, J; Gardner, R; Kryemadhi, A; Chung, Y S; Kang, J S; Ko, B R; Kwak, J W; Lee, K B; Cho, K; Park, H; Alimonti, G; Barberis, S; Boschini, M; Cerutti, A; D'Angelo, P; Di Corato, M; Dini, P; Edera, L; Erba, S; Inzani, P; Leveraro, F; Malvezzi, S; Menasce, D; Mezzadri, M; Moroni, L; Pedrini, D; Pontoglio, C; Prelz, F; Rovere, M; Sala, S; Davenport, T F; Arena, V; Boca, G; Bonomi, G; Gianini, G; Liguori, G; Lopes-Pegna, D; Merlo, M M; Pantea, D; Ratti, S P; Riccardi, C; Vitulo, P; Göbel, C; Hernández, H; López, A M; Méndez, H; Paris, A; Quinones, J; Ramírez, J E; Zhang, Y; Wilson, J R; Handler, T; Mitchell, R; Engh, D; Hosack, M; Johns, W E; Luiggi, E; Moore, J E; Nehring, M; Sheldon, P D; Vaandering, E W; Webster, M; Sheaff, M

    2005-01-01

    Using data from the FOCUS experiment (FNAL-E831), we study the decay of $\\Lambda^+_c$ baryons into final states containing a $\\Lambda$ hyperon. The branching fractions of $\\Lambda^+_c$ into $\\Lambda \\pi^+$, $\\Lambda \\pi^+ \\pi^+ \\pi^-$ and $\\Lambda \\bar{K} ^0 K^+$ relative to that into $pK^-\\pi^+$ are measured to be $0.217 \\pm 0.013 \\pm 0.020$, $0.508 \\pm 0.024 \\pm 0.024$ and $0.142 \\pm 0.018 \\pm 0.022$, respectively. We also report new measurements of $\\frac{\\Gamma(\\Lambda^+_c \\to \\Sigma^0 \\pi^+)}{\\Gamma(\\Lambda^+_c \\to \\Lambda \\pi^+)} = 1.09 \\pm 0.11 \\pm 0.19$, $\\frac{\\Gamma(\\Lambda^+_c \\to \\Sigma^0 \\pi^+\\pi^+ \\pi^-)}{\\Gamma(\\Lambda^+_c \\to \\Lambda \\pi^+ \\pi^+ \\pi^-)} = 0.26 \\pm 0.06 \\pm 0.09$ and $\\frac{\\Gamma(\\Lambda^+_c \\to \\Xi(1690)^0(\\Lambda \\bar{K} ^0) K^+)}{\\Gamma(\\Lambda^+_c \\to \\Lambda \\bar{K} ^0 K^+)} = 0.33 \\pm 0.10 \\pm 0.04$. Further, an analysis of the subresonant structure for the $\\Lambda^+_c \\to \\Lambda \\pi^+\\pi^+\\pi^-$ decay mode is presented.

  4. Lambda-Lambda interaction from two-particle intensity correlation in relativistic heavy-ion collisions

    CERN Document Server

    Ohnishi, Akira; Furumoto, Takenori

    2015-01-01

    We investigate $\\Lambda\\Lambda$ interaction dependence of the $\\Lambda\\Lambda$ intensity correlation in high-energy heavy-ion collisions. By analyzing the correlation data recently obtained by the STAR collaboration based on theoretically proposed $\\Lambda\\Lambda$ interactions, we give a constraint on the $\\Lambda\\Lambda$ scattering length, $-1.25~\\text{fm} < a_0 < 0$, suggesting that $\\Lambda\\Lambda$ interaction is weakly attractive and there is no loosely bound state. In addition to the fermionic quantum statistics and the $\\Lambda\\Lambda$ interaction, effects of collective flow, feed-down from $\\Sigma^0$, and the residual source are also found to be important to understand the data. We demonstrate that the correlation data favor negative $\\Lambda\\Lambda$ scattering length with the pair purity parameter $\\lambda=(0.67)^2$ evaluated by using experimental data on the $\\Sigma^0/\\Lambda$ ratio, while the positive scattering length could be favored when we regard $\\lambda$ as a free fitting parameter.

  5. Puzzle of the $\\Lambda_c$ spectrum

    CERN Document Server

    Lü, Qi-Fang; Liu, Xiang; Matsuki, Takayuki

    2016-01-01

    There is a puzzle in the $\\Lambda_c^+$ family, i.e., one member with $J^P=3/2^+$ is missing in a $L=2$ multiplet which the heavy quark effective theory predicts, and $J^P$'s of $\\Lambda_c(2765)^+$ and $\\Lambda_c(2940)^+$ are unknown. Using a light diquark picture to calculate baryon masses, we study possible assignments of two $\\Lambda_c$'s with unknown $J^P$ and the missing $\\Lambda_c^+$ with $3/2^+$ for $L=2$, and we find the most probable possibility that the peak corresponding to $\\Lambda_c(2880)^+$ actually includes a missing member with spin $3/2^+$ for $L=2$ and that quantum numbers of $\\Lambda_c(2765)^+$ and $\\Lambda_c(2940)^+$ are $2S(1/2^+)$ and $2P(1/2^-)$, respectively.

  6. Lambda-mu-calculus and Bohm's theorem

    OpenAIRE

    David, René; Py, Walter

    2001-01-01

    The lambda mu-calculus is an extension of the lambda-calculus that has been introduced by M. Parigot to give an algorithmic content to classical proofs. We show that Bohm's theorem fails in this calculus.

  7. Charge symmetry breaking in $\\Lambda$ hypernuclei revisited

    CERN Document Server

    Gal, Avraham

    2015-01-01

    The large charge symmetry breaking (CSB) implied by the $\\Lambda$ binding energy difference $\\Delta B^{4}_{\\Lambda}(0^+_{\\rm g.s.})\\equiv B_{\\Lambda}(_{\\Lambda}^4$He)$-$$B_{\\Lambda}(_{\\Lambda}^4$H) = 0.35$\\pm$0.06 MeV of the $A=4$ mirror hypernuclei ground states, determined from emulsion studies, has defied theoretical attempts to reproduce it in terms of CSB in hyperon masses and in hyperon-nucleon interactions, including one pion exchange arising from $\\Lambda-\\Sigma^0$ mixing. Using a schematic strong-interaction $\\Lambda N\\leftrightarrow\\Sigma N$ coupling model developed by Akaishi and collaborators for $s$-shell $\\Lambda$ hypernuclei, we revisit the evaluation of CSB in the $A=4$ $\\Lambda$ hypernuclei and extend it to $p$-shell mirror $\\Lambda$ hypernuclei. The model yields values of $\\Delta B^{4}_{\\Lambda} (0^+_{\\rm g.s.})\\sim 0.25$ MeV. Smaller size and mostly negative $p$-shell binding energy differences are calculated for the $A=7-10$ mirror hypernuclei, in rough agreement with the few available dat...

  8. Graphic lambda calculus and knot diagrams

    OpenAIRE

    Buliga, Marius

    2012-01-01

    In arXiv:1207.0332 [cs.LO] was proposed a graphic lambda calculus formalism, which has sectors corresponding to untyped lambda calculus and emergent algebras. Here we explore the sector covering knot diagrams, which are constructed as macros over the graphic lambda calculus.

  9. The differential lambda-mu-calculus

    OpenAIRE

    Vaux, Lionel

    2007-01-01

    We define a differential lambda-mu-calculus which is an extension of both Parigot's lambda-mu-calculus and Ehrhard- Regnier's differential lambda-calculus. We prove some basic properties of the system: reduction enjoys Church-Rosser and simply typed terms are strongly normalizing.

  10. Effective mass of a. lambda. -particle in nuclear matter and OBE. lambda. -n interactions

    Energy Technology Data Exchange (ETDEWEB)

    Bando, H. (Fukui Univ. (Japan). Faculty of Engineering); Nagata, S.

    1982-02-01

    The effective mass of a lambda particle (M sub( lambda )*) in nuclear matter is investigated within the framework of the lowest-order Brueckner theory by employing the Nijmegen OBE lambda -N interaction model D and F. The non-locality mass (M tilde sub( lamda )) and the energy mass (anti M sub( lambda )) are evaluated and discussed in the light of the characteristics of the two models. In comparison with the model D, the model F yields smaller anti M sub( lambda ) and larger anti M sub( lamb da ) reflecting the stronger Majorana exchange force and the stronger lambda N- sigma N coupling tensor force. Final results of M sub( lambda )*/M sub( lambda ) are 0.85 for D and 0.79 for F. In view of the effective lambda mass inferred from observed properties of the single particle potential for lambda , the model D interaction seems to be more adequate.

  11. Bacteriophages of methanotrophic bacteria

    Energy Technology Data Exchange (ETDEWEB)

    Tyutikow, F.M. (All-Union Research Inst. for Genetics and Selection of Industrial Microorganisms, Moscow, USSR); Bespalova, I.A.; Rebentish, B.A.; Aleksandrushkina, N.N.; Krivisky, A.S.

    1980-10-01

    Bacteriophages of methanotrophic bacteria have been found in 16 out of 88 studied samples (underground waters, pond water, soil, gas and oil installation waters, fermentor cultural fluids, bacterial paste, and rumen of cattle) taken in different geographic zones of the Soviet Union. Altogether, 23 phage strains were isolated. By fine structure, the phages were divided into two types (with very short or long noncontractile tails); by host range and serological properties, they fell into three types. All phages had guanine- and cytosine-rich double-stranded deoxyribonucleic acid consisting of common nitrogen bases. By all of the above-mentioned properties, all phages within each of the groups were completely identical to one another, but differed from phages of other groups.

  12. Genetically modified bacteriophages.

    Science.gov (United States)

    Sagona, Antonia P; Grigonyte, Aurelija M; MacDonald, Paul R; Jaramillo, Alfonso

    2016-04-18

    Phages or bacteriophages, viruses that infect and replicate inside bacteria, are the most abundant microorganisms on earth. The realization that antibiotic resistance poses a substantial risk to the world's health and global economy is revitalizing phage therapy as a potential solution. The increasing ease by which phage genomes can be modified, owing to the influx of new technologies, has led to an expansion of their natural capabilities, and a reduced dependence on phage isolation from environmental sources. This review will discuss the way synthetic biology has accelerated the construction of genetically modified phages and will describe the wide range of their applications. It will further provide insight into the societal and economic benefits that derive from the use of recombinant phages in various sectors, from health to biodetection, biocontrol and the food industry.

  13. Genetically modified bacteriophages.

    Science.gov (United States)

    Sagona, Antonia P; Grigonyte, Aurelija M; MacDonald, Paul R; Jaramillo, Alfonso

    2016-04-18

    Phages or bacteriophages, viruses that infect and replicate inside bacteria, are the most abundant microorganisms on earth. The realization that antibiotic resistance poses a substantial risk to the world's health and global economy is revitalizing phage therapy as a potential solution. The increasing ease by which phage genomes can be modified, owing to the influx of new technologies, has led to an expansion of their natural capabilities, and a reduced dependence on phage isolation from environmental sources. This review will discuss the way synthetic biology has accelerated the construction of genetically modified phages and will describe the wide range of their applications. It will further provide insight into the societal and economic benefits that derive from the use of recombinant phages in various sectors, from health to biodetection, biocontrol and the food industry. PMID:26906932

  14. First Measurement of the Ratio of Branching Fractions B(Lambda_b to Lambda_c mu nu)/B(Lambda_b to Lambda_c pi)

    CERN Document Server

    Adelman, J; Akimoto, T; Albrow, M G; Alvarez Gonzlez, B; Ameriow, S; Amidei, D; Anastassov, a A; Annovi, A; Antos, J; Apollinari, G; Apresyan, A; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Aurisano, A; Azfar, F; Azzurriz, P; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Bartsch, V; Bauer, G; Beauchemin, P H; Bedeschi, F; Beecher, D; Behari, S; Bellettini, Giorgio; Bellinger, J; Benjamin, D; Beretvas, A; Beringer, J; Bhatti, A; Binkley, M; Bisellow, D; Bizjakcc, I; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bölla, G; Bortoletto, D; Boudreau, J; Boveia, A; Braua, B; Bridgeman, A; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, Yu; Budd, H S; Budd, S; Burke, S; Burkett, K; Busettow, G; Busseyk, P; Buzatu, A; Byrum, K L; Cabrerau, S; Calancha, C; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carls, B; Carlsmith, D; Carosi, R; Carrillom, S; Carron, S; Casal, B; Casarsa, M; Castrov, A; Catastiniy, P; Cauzbb, D; Cavalierey, V; Cavalli-Sforza, M; Cerri, A; Cerriton, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, K; Chokheli, D; Chou, J P; Choudalakis, G; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Chwalek, T; Ciobanu, C I; Ciocciy, M A; Clark, A; Clark, D; Compostella, G; Convery, M E; Conway, J; Cordelli, M; Cortianaw, G; Cox, C A; Cox, D J; Cresciolix, F; Cuenca Almenaru, C; Cuevasr, J; Culbertson, R; Cully, J C; Dagenhart, D; Datta, M; Davies, T; De Barbaro, P; De Cecco, S; Deisher, A; De Lorenzo, G; Dell'Orsox, M; Deluca, C; Demortier, L; Deng, J; Deninno, M; Derwent, P F; di Giovanni, G P; Dionisiaa, C; Di Ruzzabb, B; Dittmann, J R; D'Onofrio, M; Donatix, S; Dong, P; Donini, J; Dorigo, T; Dube, S; Efron, J; Elagin, A; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, W T; Feild, R G; Feindt, M; Fernández, J P; Ferrazzaz, C; Field, R; Flanagan, G; Forrest, R; Frank, M J; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garberson, F; García, J E; Garfinkel, A F; Genser, K; Gerberich, H; Gerdes, D; Gessler, A; Giaguaa, S; Giakoumopoulou, V; Giannetti, P; Gibson, K; Gimmell, J L; Ginsburg, C M; Giokaris, N; Giordanibb, M; Giromini, P; Giuntax, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Golossanov, A; Gómez, G; Gómez-Ceballos, G; Goncharov, M; Gonzlez, O; Gorelov, I; Goshaw, A T; Goulianos, K; Greselew, A; Grinstein, S; Grosso-Pilcher, a C; Group, R C; Grundler, U; Guimarães da Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Han, B Y; Han, J Y; Happacher, F; Hara, K; Hare, D; Hare, M; Harper, S; Harr, R F; Harris, R M; Hartz, M; Hatakeyama, K; Hays, C; Heck, M; Heijboer, A; Heinrich, J; Henderson, C; Herndon, M; Heuser, J; Hewamanage, S; Hidas, D; Hillc, C S; Hirschbuehl, D; Höcker, A; Hou, S; Houlden, M; Hsu, S C; Huffman, B T; Hughes, R E; Husemann, U; Hussein, M; Husemann, U; Huston, J; Incandela, J; Introzzi, G; Ioriaa, M; Ivanov, A; James, E; Jayatilaka, B; Jeon, E J; Jha, M K; Jindariani, S; Johnson, W; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Kar, D; Karchin, P E; Kato, Y; Kephart, R; Keung, J; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, H W; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Knuteson, B; Ko, B R; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kreps, M; Kroll, J; Krop, D; Krumnack, N; Kruse, M; Krutelyov, V; Kubo, T; Kuhr, T; Kulkarni, N P; Kurata, M; Kusakabe, Y; Kwang, S; Laasanen, A T; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannonq, K; Lath, A; Latinoy, G; Lazzizzeraw, I; LeCompte, T; Lee, E; Lee, H S; Leet, S W; Leone, S; Lewis, J D; Lin, C S; Linacre, J; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, C; Liu, T; Lockyer, N S; Loginov, A; Loretiw, M; Lovas, L; Lucchesiw, D; Luciaa, C; Lueck, J; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; MacQueen, D; Madrak, R; Maeshima, K; Makhoul, K; Mäki, T; Maksimovic, P; Malde, S; Malik, S; Mancae, G; Manousakis-Katsikakis, A; Margaroli, F; Marino, C; Marino, C P; Martin, A; Martinl, V; Martínez, M; Martinez-Ballarin, R; Maruyama, T; Mastrandrea, iii P; Masubuchi, T; Mathis, M; Mattson, M E; Mazzanti, P; McFarland, K S; McIntyre, P; McNultyj, R; Mehta, A; Mehtälä, P; Menzione, A; Merkel, P; Mesropian, C; Miao, T; Miladinovic, N; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyake, H; Moggi, N; Moon, C S; Moore, R; Morellox, M J; Morlok, J; Movilla-Fernández, P A; Mülmenstädt, J; Mukherjee, A; Müller, T; Mumford, R; Murat, P; Mussiniv, M; Nachtman, J; Nagai, Y; Nagano, A; Naganoma, J; Nakamura, K; Nakano, I; Napier, A; Necula, V; Nett, J; Neuv, C; Neubauer, M S; Neubauer, S; Nielseng, J; Nodulman, L; Norman, M; Norniella, O; Nurse, E; Oakes, L; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Orava, R

    2008-01-01

    The analysis uses data from an integrated luminosity of approximately 172 pb-1 of ppbar collisions at sqrt(s)=1.96 TeV, collected with the CDF II detector at the Fermilab Tevatron. The Lambda_b and B0 relative branching fractions are measured to be: B(Lambda_b to Lambda_c+ mu nu)/B(Lambda_b to Lambda_c+ pi) = 16.6 +- 3.0 (stat) +- 1.0 (syst) +2.6 -3.4 (PDG) +- 0.3 (EBR), B(B0 to D+ mu nu)/B(B0 to D+ pi) = 9.9 +- 1.0 (stat) +- 0.6 (syst) +- 0.4 (PDG) +- 0.5 (EBR), B(B0 to D*+ mu nu)/B(B0 to D*+ pi) = 16.5 +- 2.3 (stat) +- 0.6 (syst) +- 0.5 (PDG) +- 0.8 (EBR) This article also presents measurements of the branching fractions of four new Lambda_b semileptonic decays: Lambda_b to Lambda_c(2595)+ mu nu, Lambda_b to Lambda_c(2625)+ mu nu, Lambda_b to Sigma_c(2455)0 pi mu nu, Lambda_b to Sigma_c(2455)++ pi mu nu, relative to the branching fraction of the Lambda_b to Lambda_c mu nu decay. Finally, the transverse-momentum distribution of Lambda_b baryons produced in p-pbar collisions is measured and found to be signif...

  15. Telluric lines in the region lambda lambda 6327.5-6330.0 angstrom angstrom

    Science.gov (United States)

    Alikayeva, K. V.

    1973-01-01

    The solar spectrum region lambda lambda 6327.5 to 6330.0 AA was investigated. Six new telluric lines were found. The behavior of two of them (lambda 6328.51 and lambda 6328.71 A) is the same as identified molecular oxygen lines in the region. The lines lambda 6328.27, 6329.12, and 6329.29 A are more intensive when there are days with high humidity.

  16. A Study of $\\left(\\lambda ,\\mu \\right)$ -Fuzzy Subgroups

    OpenAIRE

    Li, Yuying; Wang, Xuzhu; Yang, Liqiong

    2013-01-01

    We deal with topics regarding $\\left(\\lambda ,\\mu \\right)$ -fuzzy subgroups, mainly $\\left(\\lambda ,\\mu \\right)$ -fuzzy cosets and $\\left(\\lambda ,\\mu \\right)$ -fuzzy normal subgroups. We give basic properties of $\\left(\\lambda ,\\mu \\right)$ -fuzzy subgroups and present some results related to $\\left(\\lambda ,\\mu \\right)$ -fuzzy cosets and $\\left(\\lambda ,\\mu \\right)$ -fuzzy normal subgroups.

  17. The $a_0(980)$ and $\\Lambda(1670)$ in the $\\Lambda^+_c \\to \\pi^+ \\eta \\Lambda$ decay

    CERN Document Server

    Xie, Ju-Jun

    2016-01-01

    We propose to study the $a_0(980)$ and the $\\Lambda(1670)$ resonances in the $\\Lambda^+_c \\to \\pi^+ \\eta \\Lambda$ decay via the final state interactions of the $\\pi^+ \\eta$ and $\\eta \\Lambda$ pairs. The weak interaction part proceeds through the $c$ quark decay process: $c(ud) \\to (s + u + \\bar d)(ud)$, while the hadronization part takes place in two different mechanisms. In the first mechanism, the $sud$ cluster picks up a $q\\bar{q}$ pair from the vacuum to form the $\\eta\\Lambda$ meson-baryon pair while the $u\\bar{d}$ pair from the weak decay hadronizes into a $\\pi^+$. In the second, the $sud$ cluster turns into a $\\Lambda$, while the $u\\bar{d}$ pair from the $c$ decay picks up a $q\\bar{q}$ pair and hadronizes into a meson-meson pair ($\\pi\\eta$ or $K\\bar{K}$). Because the final $\\pi^+ \\eta$ and $\\eta \\Lambda$ states are in pure isospin $I = 1$ and $I=0$ combinations, the $\\Lambda^+_c \\to \\pi^+ \\eta \\Lambda$ decay can be an ideal process to study the $a_0(980)$ and $\\Lambda(1670)$ resonances. Describing the f...

  18. A Measurement of the Product Branching Ratio $f(b \\to \\Lambda_{b}).BR (\\Lambda_{b} \\to \\Lambda X)$ in $Z^{0}$ Decays

    CERN Document Server

    Abbiendi, G; Alexander, Gideon; Allison, J; Altekamp, N; Anderson, K J; Anderson, S; Arcelli, S; Asai, S; Ashby, S F; Axen, D A; Azuelos, Georges; Ball, A H; Barberio, E; Barlow, R J; Bartoldus, R; Batley, J Richard; Baumann, S; Bechtluft, J; Behnke, T; Bell, K W; Bella, G; Bellerive, A; Bentvelsen, Stanislaus Cornelius Maria; Bethke, Siegfried; Betts, S; Biebel, O; Biguzzi, A; Bird, S D; Blobel, Volker; Bloodworth, Ian J; Bock, P; Böhme, J; Bonacorsi, D; Boutemeur, M; Braibant, S; Bright-Thomas, P G; Brigliadori, L; Brown, R M; Burckhart, Helfried J; Capiluppi, P; Carnegie, R K; Carter, A A; Carter, J R; Chang, C Y; Charlton, D G; Chrisman, D; Ciocca, C; Clarke, P E L; Clay, E; Cohen, I; Conboy, J E; Cooke, O C; Couyoumtzelis, C; Coxe, R L; Cuffiani, M; Dado, S; Dallavalle, G M; Darling, C L; Davis, R; De Jong, S; de Roeck, A; Dervan, P J; Desch, Klaus; Dienes, B; Dixit, M S; Dubbert, J; Duchovni, E; Duckeck, G; Duerdoth, I P; Eatough, D; Estabrooks, P G; Etzion, E; Fabbri, Franco Luigi; Fanti, M; Faust, A A; Fiedler, F; Fierro, M; Fleck, I; Folman, R; Fürtjes, A; Futyan, D I; Gagnon, P; Gary, J W; Gascon, J; Gascon-Shotkin, S M; Gaycken, G; Geich-Gimbel, C; Giacomelli, G; Giacomelli, P; Gibson, V; Gibson, W R; Gingrich, D M; Glenzinski, D A; Goldberg, J; Gorn, W; Grandi, C; Graham, K; Gross, E; Grunhaus, Jacob; Gruwé, M; Hanson, G G; Hansroul, M; Hapke, M; Harder, K; Harel, A; Hargrove, C K; Hartmann, C; Hauschild, M; Hawkes, C M; Hawkings, R; Hemingway, Richard J; Herndon, M; Herten, G; Heuer, R D; Hildreth, M D; Hill, J C; Hobson, P R; Hoch, M; Höcker, Andreas; Hoffman, K; Homer, R James; Honma, A K; Horváth, D; Hossain, K R; Howard, R; Hüntemeyer, P; Igo-Kemenes, P; Imrie, D C; Ishii, K; Jacob, F R; Jawahery, A; Jeremie, H; Jimack, Martin Paul; Jones, C R; Jovanovic, P; Junk, T R; Karlen, D A; Kartvelishvili, V G; Kawagoe, K; Kawamoto, T; Kayal, P I; Keeler, Richard K; Kellogg, R G; Kennedy, B W; Kim, D H; Klier, A; Kluth, S; Kobayashi, T; Kobel, M; Koetke, D S; Kokott, T P; Kolrep, M; Komamiya, S; Kowalewski, R V; Kress, T; Krieger, P; Von Krogh, J; Kühl, T; Kyberd, P; Lafferty, G D; Landsman, Hagar Yaël; Lanske, D; Lauber, J; Lautenschlager, S R; Lawson, I; Layter, J G; Lazic, D; Lee, A M; Lellouch, Daniel; Letts, J; Levinson, L; Liebisch, R; List, B; Littlewood, C; Lloyd, A W; Lloyd, S L; Loebinger, F K; Long, G D; Losty, Michael J; Ludwig, J; Liu, D; Macchiolo, A; MacPherson, A L; Mader, W F; Mannelli, M; Marcellini, S; Markopoulos, C; Martin, A J; Martin, J P; Martínez, G; Mashimo, T; Mättig, P; McDonald, W J; McKenna, J A; McKigney, E A; McMahon, T J; McPherson, R A; Meijers, F; Menke, S; Merritt, F S; Mes, H; Meyer, J; Michelini, Aldo; Mihara, S; Mikenberg, G; Miller, D J; Mir, R; Mohr, W; Montanari, A; Mori, T; Nagai, K; Nakamura, I; Neal, H A; Nellen, B; Nisius, R; O'Neale, S W; Oakham, F G; Odorici, F; Ögren, H O; Oreglia, M J; Orito, S; Pálinkás, J; Pásztor, G; Pater, J R; Patrick, G N; Patt, J; Pérez-Ochoa, R; Petzold, S; Pfeifenschneider, P; Pilcher, J E; Pinfold, James L; Plane, D E; Poffenberger, P R; Polok, J; Przybycien, M B; Rembser, C; Rick, Hartmut; Robertson, S; Robins, S A; Rodning, N L; Roney, J M; Roscoe, K; Rossi, A M; Rozen, Y; Runge, K; Runólfsson, O; Rust, D R; Sachs, K; Saeki, T; Sahr, O; Sang, W M; Sarkisyan-Grinbaum, E; Sbarra, C; Schaile, A D; Schaile, O; Scharf, F; Scharff-Hansen, P; Schieck, J; Schmitt, B; Schmitt, S; Schöning, A; Schröder, M; Schumacher, M; Schwick, C; Scott, W G; Seuster, R; Shears, T G; Shen, B C; Shepherd-Themistocleous, C H; Sherwood, P; Siroli, G P; Sittler, A; Skuja, A; Smith, A M; Snow, G A; Sobie, Randall J; Söldner-Rembold, S; Spagnolo, S; Sproston, M; Stahl, A; Stephens, K; Steuerer, J; Stoll, K; Strom, D; Ströhmer, R; Surrow, B; Talbot, S D; Tanaka, S; Taras, P; Tarem, S; Teuscher, R; Thiergen, M; Thomas, J; Thomson, M A; Von Törne, E; Torrence, E; Towers, S; Trigger, I; Trócsányi, Z L; Tsur, E; Turcot, A S; Turner-Watson, M F; Ueda, I; Van Kooten, R; Vannerem, P; Verzocchi, M; Voss, H; Wäckerle, F; Wagner, A; Ward, C P; Ward, D R; Watkins, P M; Watson, A T; Watson, N K; Wells, P S; Wermes, N; White, J S; Wilson, G W; Wilson, J A; Wyatt, T R; Yamashita, S; Yekutieli, G; Zacek, V; Zer-Zion, D

    1999-01-01

    The product branching ratio, f(b->Lambda_b).BR(Lambda_b->Lambda X), where Lambda_b denotes any weakly-decaying b-baryon, has been measured using the OPAL detector at LEP. Lambda_b are selected by the presence of energetic Lambda particles in bottom events tagged by the presence of displaced secondary vertices. A fit to the momenta of the Lambda particles separates signal from B meson and fragmentation backgrounds. The measured product branching ratio is f(b->Lambda_b).BR(Lambda_b->Lambda X) = (2.67+-0.38(stat)+0.67-0.60(sy s))% Combined with a previous OPAL measurement, one obtains f(b->Lambda_b).BR(Lambda_b->Lambda X) = (3.50+-0.32(stat)+-0.35(sys ))%.

  19. Study of J/psi-->pp[over],LambdaLambda[over] and observation of eta(c)-->LambdaLambda[over] at Belle.

    Science.gov (United States)

    Wu, C-H; Wang, M-Z; Abe, K; Adachi, I; Aihara, H; Aulchenko, V; Aushev, T; Bahinipati, S; Bakich, A M; Balagura, V; Bay, A; Belous, K; Bitenc, U; Bizjak, I; Blyth, S; Bondar, A; Bozek, A; Browder, T E; Chao, Y; Chen, A; Chen, W T; Cheon, B G; Choi, Y; Choi, Y K; Chuvikov, A; Cole, S; Dalseno, J; Danilov, M; Dash, M; Eidelman, S; Gabyshev, N; Gershon, T; Go, A; Gokhroo, G; Gorisek, A; Ha, H; Haba, J; Hayasaka, K; Hayashii, H; Hazumi, M; Heffernan, D; Hokuue, T; Hou, S; Hou, W-S; Hsiung, Y B; Iijima, T; Inami, K; Ishikawa, A; Itoh, R; Iwasaki, M; Iwasaki, Y; Kang, J H; Kataoka, S U; Katayama, N; Kawai, H; Kawasaki, T; Khan, H R; Kichimi, H; Kim, H J; Kim, H O; Kim, Y J; Krizan, P; Krokovny, P; Kulasiri, R; Kumar, R; Kuo, C C; Kuzmin, A; Kwon, Y-J; Leder, G; Lee, J; Lee, Y-J; Lesiak, T; Lin, S-W; Liventsev, D; Majumder, G; Mandl, F; Matsumoto, T; Matyja, A; McOnie, S; Mitaroff, W; Miyabayashi, K; Miyake, H; Miyata, H; Miyazaki, Y; Mizuk, R; Mori, T; Nakano, E; Nakao, M; Natkaniec, Z; Nishida, S; Nitoh, O; Ogawa, S; Ohshima, T; Okabe, T; Okuno, S; Olsen, S L; Onuki, Y; Ozaki, H; Pakhlov, P; Palka, H; Park, H; Park, K S; Pestotnik, R; Piilonen, L E; Sakai, Y; Schietinger, T; Schneider, O; Schwartz, A J; Seidl, R; Sevior, M E; Shapkin, M; Shibuya, H; Sidorov, V; Sokolov, A; Somov, A; Soni, N; Stanic, S; Staric, M; Stoeck, H; Sumiyoshi, T; Takasaki, F; Tanaka, M; Taylor, G N; Teramoto, Y; Tian, X C; Tsuboyama, T; Tsukamoto, T; Uehara, S; Uglov, T; Ueno, K; Uno, S; Urquijo, P; Usov, Y; Varner, G; Wang, C C; Wang, C H; Watanabe, Y; Won, E; Yabsley, B D; Yamaguchi, A; Yamashita, Y; Zhang, L M; Zhang, Z P

    2006-10-20

    We study the baryonic charmonium decays of B mesons B+-->etacK+ and B+-->J/psiK+, where the etac and J/psi subsequently decay into a pp[over] or LambdaLambda[over] pair. We measure the J/psi-->pp[over] and LambdaLambda[over] anisotropy parameters alphaB=-0.60+/-0.13+/-0.14 (pp[over]), -0.44+/-0.51+/-0.31 (LambdaLambda[over ]) and compare to results from e;{+}e;{-}-->J/psi formation experiments. We also report the first observation of etac-->LambdaLambda[over]. The measured branching fraction is B(etac-->LambdaLambda[over ])=(0.87(+0.24)/(-0.21)(stat)(+0.09/-0.14) (syst)+/-0.27(PDG))x10-3. This study is based on a 357 fb-1 data sample recorded on the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+ e- collider. PMID:17155387

  20. Measurement of the Lambda(b) lifetime in the exclusive decay Lambda(b) ---> J / psi Lambda

    Energy Technology Data Exchange (ETDEWEB)

    Abazov, V.M.; Abbott, B.; Abolins, M.; Acharya, B.S.; Adams, M.; Adams, T.; Aguilo, E.; Ahn, S.H.; Ahsan, M.; Alexeev, G.D.; Alkhazov, G.; /Buenos Aires U. /Rio de Janeiro, CBPF /Rio de Janeiro State U. /Sao Paulo, IFT /Alberta U. /Simon Fraser U. /York U., Canada /McGill U. /Hefei, CUST /Andes U., Bogota /Charles U.

    2007-04-01

    We have measured the {lambda}{sub b} lifetime using the exclusive decay {lambda}{sub b}{yields}J/{psi}{lambda}, based on 1.2 fb{sup -1} of data collected with the D0 detector during 2002-2006. From 171 reconstructed {lambda}{sub b} decays, where the J/{psi} and {lambda} are identified via the decays J/{psi}{yields}{mu}{sup +}{mu}{sup -} and {lambda}{yields}p{pi}, we measured the {lambda}{sub b} lifetime to be {tau}({lambda}{sub b})=1.218{sub -0.115}{sup +0.130}(stat){+-}0.042(syst) ps. We also measured the B{sup 0} lifetime in the decay B{sup 0}{yields}J/{psi}({mu}{sup +}{mu}{sup -})K{sub S}{sup 0}({pi}{sup +}{pi}{sup -}) to be {tau}(B{sup 0})=1.501{sub -0.074}{sup +0.078}(stat){+-}0.050(syst) ps, yielding a lifetime ratio of {tau}({lambda}{sub b})/{tau}(B{sup 0})=0.811{sub -0.087}{sup +0.096}(stat){+-}0.034(syst = )

  1. Capstan friction model for DNA ejection from bacteriophages

    CERN Document Server

    Ghosal, Sandip

    2013-01-01

    Bacteriophages infect cells by attaching to the outer membrane and injecting their DNA into the cell.The phage DNA is then transcribed by the cell's transcription machinery.A number of physical mechanisms by which DNA can be translocated from the phage capsid into the cell have been identified. A fast ejection driven by the elastic and electrostatic potential energy of the compacted DNA within the viral capsid appears to be used by most phages, at least to initiate infection.In recent in vitro experiments, the speed of DNA translocation from a lambda phage capsid has been measured as a function of ejected length over the entire duration of the event.Here a mechanical model is proposed that is able to explain the observed dependence of exit velocity on ejected length, and that is also consistent with the accepted picture of the geometric arrangement of DNA within the viral capsid.

  2. Observation of excited $\\Lambda^0_b$ baryons

    CERN Document Server

    Aaij, R; Adametz, A; Adeva, B; Adinolfi, M; Adrover, C; Affolder, A; Ajaltouni, Z; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves Jr, A A; Amato, S; Amhis, Y; Anderson, J; Appleby, R B; Aquines Gutierrez, O; Archilli, F; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Bachmann, S; Back, J J; Balagura, V; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Bates, A; Bauer, C; Bauer, Th; Bay, A; Beddow, J; Bediaga, I; Belogurov, S; Belous, K; Belyaev, I; Ben-Haim, E; Benayoun, M; Bencivenni, G; Benson, S; Benton, J; Bernet, R; Bettler, M -O; van Beuzekom, M; Bien, A; Bifani, S; Bird, T; Bizzeti, A; Bjørnstad, P M; Blake, T; Blanc, F; Blanks, C; Blouw, J; Blusk, S; Bobrov, A; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borghi, S; Borgia, A; Bowcock, T J V; Bozzi, C; Brambach, T; van den Brand, J; Bressieux, J; Brett, D; Britsch, M; Britton, T; Brook, N H; Brown, H; Büchler-Germann, A; Burducea, I; Bursche, A; Buytaert, J; Cadeddu, S; Callot, O; Calvi, M; Calvo Gomez, M; Camboni, A; Campana, P; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carson, L; Carvalho Akiba, K; Casse, G; Cattaneo, M; Cauet, Ch; Charles, M; Charpentier, Ph; Chen, P; Chiapolini, N; Chrzaszcz, M; Ciba, K; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coca, C; Coco, V; Cogan, J; Cogneras, E; Collins, P; Comerma-Montells, A; Contu, A; Cook, A; Coombes, M; Corti, G; Couturier, B; Cowan, G A; Craik, D; Currie, R; D'Ambrosio, C; David, P; David, P N Y; De Bonis, I; De Bruyn, K; De Capua, S; De Cian, M; De Miranda, J M; De Paula, L; De Simone, P; Decamp, D; Deckenhoff, M; Degaudenzi, H; Del Buono, L; Deplano, C; Derkach, D; Deschamps, O; Dettori, F; Dickens, J; Dijkstra, H; Diniz Batista, P; Domingo Bonal, F; Donleavy, S; Dordei, F; Dosil Suárez, A; Dossett, D; Dovbnya, A; Dupertuis, F; Dzhelyadin, R; Dziurda, A; Dzyuba, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; van Eijk, D; Eisele, F; Eisenhardt, S; Ekelhof, R; Eklund, L; El Rifai, I; Elsasser, Ch; Elsby, D; Esperante Pereira, D; Falabella, A; Färber, C; Fardell, G; Farinelli, C; Farry, S; Fave, V; Fernandez Albor, V; Ferro-Luzzi, M; Filippov, S; Fitzpatrick, C; Fontana, M; Fontanelli, F; Forty, R; Francisco, O; Frank, M; Frei, C; Frosini, M; Furcas, S; Gallas Torreira, A; Galli, D; Gandelman, M; Gandini, P; Gao, Y; Garnier, J-C; Garofoli, J; Garra Tico, J; Garrido, L; Gascon, D; Gaspar, C; Gauld, R; Gauvin, N; Gersabeck, M; Gershon, T; Ghez, Ph; Gibson, V; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gordon, H; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graziani, G; Grecu, A; Greening, E; Gregson, S; Grünberg, O; Gui, B; Gushchin, E; Guz, Yu; Gys, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hampson, T; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; Harrison, P F; Hartmann, T; He, J; Heijne, V; Hennessy, K; Henrard, P; Hernando Morata, J A; van Herwijnen, E; Hicks, E; Hoballah, M; Hopchev, P; Hulsbergen, W; Hunt, P; Huse, T; Huston, R S; Hutchcroft, D; Hynds, D; Iakovenko, V; Ilten, P; Imong, J; Jacobsson, R; Jaeger, A; Jahjah Hussein, M; Jans, E; Jansen, F; Jaton, P; Jean-Marie, B; Jing, F; John, M; Johnson, D; Jones, C R; Jost, B; Kaballo, M; Kandybei, S; Karacson, M; Karbach, T M; Keaveney, J; Kenyon, I R; Kerzel, U; Ketel, T; Keune, A; Khanji, B; Kim, Y M; Knecht, M; Kochebina, O; Komarov, I; Koopman, R F; Koppenburg, P; Korolev, M; Kozlinskiy, A; Kravchuk, L; Kreplin, K; Kreps, M; Krocker, G; Krokovny, P; Kruse, F; Kruzelecki, K; Kucharczyk, M; Kudryavtsev, V; Kvaratskheliya, T; La Thi, V N; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lambert, R W; Lanciotti, E; Lanfranchi, G; Langenbruch, C; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J -P; Lefèvre, R; Leflat, A; Lefrançois, J; Leroy, O; Lesiak, T; Li, L; Li, Y; Li Gioi, L; Lieng, M; Liles, M; Lindner, R; Linn, C; Liu, B; Liu, G; von Loeben, J; Lopes, J H; Lopez Asamar, E; Lopez-March, N; Lu, H; Luisier, J; Mac Raighne, A; Machefert, F; Machikhiliyan, I V; Maciuc, F; Maev, O; Magnin, J; Malde, S; Mamunur, R M D; Manca, G; Mancinelli, G; Mangiafave, N; Marconi, U; Märki, R; Marks, J; Martellotti, G; Martens, A; Martin, L; Martín Sánchez, A; Martinelli, M; Martinez Santos, D; Massafferri, A; Mathe, Z; Matteuzzi, C; Matveev, M; Maurice, E; Maynard, B; Mazurov, A; McCarthy, J; McGregor, G; McNulty, R; Meissner, M; Merk, M; Merkel, J; Milanes, D A; Minard, M -N; Molina Rodriguez, J; Monteil, S; Moran, D; Morawski, P; Mountain, R; Mous, I; Muheim, F; Müller, K; Muresan, R; Muryn, B; Muster, B; Mylroie-Smith, J; Naik, P; Nakada, T; Nandakumar, R; Nasteva, I; Needham, M; Neufeld, N; Nguyen, A D; Nguyen-Mau, C; Nicol, M; Niess, V; Nikitin, N; Nikodem, T; Nomerotski, A; Novoselov, A; Oblakowska-Mucha, A; Obraztsov, V

    2012-01-01

    Using $pp$ collision data corresponding to 1.0~fb^{-1} integrated luminosity collected by the LHCb detector, two narrow states are observed in the $\\Lambda_b^0\\pi^+\\pi^-$ spectrum with masses $5911.95\\pm 0.12(\\mbox{stat})\\pm 0.03(\\mbox{syst})\\pm 0.66(\\Lambda_b^0\\mbox{ mass})$ MeV/$c^2$ and $5919.76\\pm 0.07(\\mbox{stat})\\pm 0.02(\\mbox{syst})\\pm 0.66(\\Lambda_b^0\\mbox{ mass})$ MeV/$c^2$. The significances of the observations are 4.9 and 10.1 standard deviations, respectively. These states are interpreted as the orbitally-excited $\\Lambda_b^0$ baryons, $\\Lambda_b^{*0}(5912)$ and $\\Lambda_b^{*0}(5920)$.

  3. Virulence reduction in Bacteriophage resistant bacteria

    Directory of Open Access Journals (Sweden)

    Marcela eLeón

    2015-04-01

    Full Text Available Bacteriophages can influence the abundance, diversity and evolution of bacterial communities. Several bacteriophages have been reported to add virulence factors to their host and to increase bacterial virulence. However, lytic bacteriophages can also exert a selective pressure allowing the proliferation of strains with reduced virulence. This reduction can be explained because bacteriophages use structures present on the bacterial surface as receptors, which can be virulence factors in different bacterial species. Therefore, strains with modifications in these receptors will be resistant to bacteriophage infection and may also exhibit reduced virulence. This mini-review summarizes the reports on bacteriophage-resistant strains with reductions in virulence, and it discusses the potential consequences in phage therapy and in the use of bacteriophages to select attenuated strains for vaccines.

  4. Probing the viral metallome: searching for metalloproteins in bacteriophage λ-- the hunt begins.

    Science.gov (United States)

    Zhang, Yaofang; Thompson, Richard; Caruso, Joseph

    2011-05-01

    Although the proteome and genome of bacteriophages are well developed, there is little knowledge about metals and their interactions with the phages, even though metals have been observed in stabilizing phage particles. With expanding studies of phage display and its promising applications, metalloprotein investigations in the bacteriophage areas are necessary to understand whether or not metalloproteins are included in the viral coat proteome. Since these virus studies are still in their infancy, lambda phage was chosen due to its high metal-binding potential as suggested by the cysteine/methionine rich proteins in the viral coat. After large-scale preparation and further purification of lambda phage according to standard protocols, state-of-the-art metallomics techniques via combinations of chromatographies and mass spectrometries were utilized for screening metal-associated species in lambda phage. The lambda phage sample was first separated using non-denaturing size exclusion chromatography with selective metal detection by ICPMS for screening associated metals and generating size distribution fractions for the various metal species, some of which include metalloproteins. Various molecular size distribution patterns were exhibited for the metals detected, Mn, Fe, Co, Ni, Cu and Zn, at different molecular weight ranges. On the other hand numerous other metals were not associated with the coat proteins, as they were not detected in the different molecular weight fractions. Further identification for putative metallopeptides and metalloproteins was accomplished by collecting various metal species' fractions offline and subsequently analyzing tryptically-digested fractions via nanoLC-Chip-ESI-MS. By searching appropriate MS databases with both Spectrum Mill and MASCOT search engines, the main capsid protein, gpE, a capsid decoration protein, gpD, and main tail component protein, gpV, were found and are known for associations with the detected transition metals

  5. Probing Lambda-DGP Braneworld Model

    CERN Document Server

    Ravanpak, A; Fadakar, G F

    2016-01-01

    In this article we study cosmic dynamics in the context of normal branch of DGP braneworld model. Using the current Planck data, we best fit the model and cosmological parameters in non-flat $\\Lambda$DGP. With the transition redshift as a basic variable and statefinder parameters, our result shows that the Universe starts its accelerated expansion phase, slightly earlier than expected in $\\Lambda$CDM cosmology. The result also alleviates the coincidence problem of the $\\Lambda$CDM model.

  6. Ordered Models of the Lambda Calculus

    OpenAIRE

    Salibra, Antonino; Carraro, Alberto

    2013-01-01

    Answering a question by Honsell and Plotkin, we show that there are two equations between lambda terms, the so-called subtractive equations, consistent with lambda calculus but not simultaneously satisfied in any partially ordered model with bottom element. We also relate the subtractive equations to the open problem of the order-incompleteness of lambda calculus, by studying the connection between the notion of absolute unorderability in a specific point and a weaker notion of subtractivity ...

  7. Lambda_b -> Lambda l+ l- form factors and differential branching fraction from lattice QCD

    CERN Document Server

    Detmold, William; Meinel, Stefan; Wingate, Matthew

    2012-01-01

    We present the first lattice QCD determination of the $\\Lambda_b \\to \\Lambda$ transition form factors that govern the rare baryonic decays $\\Lambda_b \\to \\Lambda l^+ l^-$ at leading order in heavy-quark effective theory. Our calculations are performed with 2+1 flavors of domain-wall fermions, at two lattice spacings and with pion masses down to 227 MeV. Three-point functions with a wide range of source-sink separations are used to extract the ground-state contributions. The form factors are extrapolated to the physical values of the light-quark masses and to the continuum limit. We use our results to calculate the differential branching fractions for $\\Lambda_b \\to \\Lambda l^+ l^-$ with $l=e,\\mu,\\tau$ within the standard model. We find agreement with a recent CDF measurement of the $\\Lambda_b \\to \\Lambda \\mu^+ \\mu^-$ differential branching fraction.

  8. Transverse polarization of {Lambda} and {bar {Lambda}} hyperons in quasireal photoproduction.

    Energy Technology Data Exchange (ETDEWEB)

    Airapetian, A.; Akopov, N.; Amarian, M.; Ammosov, V. V.; Andrus, A.; Elalaoui-Moulay, A.; Hafidi, K.; Jackson, H. E.; Potterveld, D. H.; Reimer, P. E.; Sanjiev, I.; Physics; Yerevan Physics Inst.; Inst. Nazionaled di Fisica Nucleare; Inst. High Energy Physics

    2007-11-01

    The HERMES experiment has measured the transverse polarization of Lambda and {ovr Lambda} hyperons produced inclusively in quasireal photoproduction at a positron beam energy of 27.6 GeV. The transverse polarization P{sub n}{sup Lambda} of the Lambda hyperon is found to be positive while the observed {ovr Lambda} polarization is compatible with zero. The values averaged over the kinematic acceptance of HERMES are P{sub n}{sup Lambda} =0.078 {+-} 0.006(stat) {+-} 0.012(syst) and P{sub n}{sup {ovr Lambda}} = -0.025 {+-} 0.015(stat) {+-} 0.018(syst) for Lambda and {ovr Lambda}, respectively. The dependences of P{sub n}{sup Lambda} and P{sub n}{sup {ovr Lambda}} on the fraction zeta of the beam's light-cone momentum carried by the hyperon and on the hyperon's transverse momentum p{sub T} were investigated. The measured Lambda polarization rises linearly with p{sub T} and exhibits a different behavior for low and high values of zeta, which approximately correspond to the backward and forward regions in the center-of-mass frame of the gamma*N reaction.

  9. Lattice QCD calculation of form factors for $\\Lambda_b \\to \\Lambda(1520) \\ell^+ \\ell^-$ decays

    CERN Document Server

    Meinel, Stefan

    2016-01-01

    Experimental results for mesonic $b \\to s \\mu^+ \\mu^-$ decays show a pattern of deviations from Standard-Model predictions, which could be due to new fundamental physics or due to an insufficient understanding of hadronic effects. Additional information on the $b \\to s \\mu^+ \\mu^-$ transition can be obtained from $\\Lambda_b$ decays. This was recently done using the process $\\Lambda_b \\to \\Lambda \\mu^+ \\mu^-$, where the $\\Lambda$ is the lightest strange baryon. A further interesting channel is $\\Lambda_b \\to p^+ K^- \\mu^+ \\mu^-$, where the $p^+ K^-$ final state receives contributions from multiple higher-mass $\\Lambda$ resonances. The narrowest and most prominent of these is the $\\Lambda(1520)$, which has $J^P=\\frac32^-$. Here we present an ongoing lattice QCD calculation of the relevant $\\Lambda_b \\to \\Lambda(1520)$ form factors. We discuss the choice of interpolating field for the $\\Lambda(1520)$, and explain our method for extracting the fourteen $\\Lambda_b \\to \\Lambda(1520)$ helicity form factors from corr...

  10. Bacteriophages: back to the future

    Science.gov (United States)

    A Listeria monocytogenes-specific bacteriophage cocktail (ListShield™) was evaluated for its activity against a nalidixic acid-resistant L. monocytogenes (Lm-NalR) isolate on fresh-cut spinach stored under modified atmosphere packaging (MAP) at various temperatures. Pieces (~2x2 cm2) of fresh spinac...

  11. Bacteriophage endolysins as novel antimicrobials

    Science.gov (United States)

    Endolysins are enzymes used by bacteriophages at the end of their replication cycle to degrade the peptidoglycan of the bacterial host from within, resulting in cell lysis and release of progeny virions. Due to the absence of an outer membrane in the Gram-positive bacterial cell wall, endolysins can...

  12. Nanoscale bacteriophage biosensors beyond phage display

    Directory of Open Access Journals (Sweden)

    Lee JW

    2013-10-01

    Full Text Available Jong-Wook Lee,1 Jangwon Song,1,2 Mintai P Hwang,1 Kwan Hyi Lee1,2 1Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, Korea; 2Department of Biomedical Engineering, University of Science and Technology, Seoul, Korea Abstract: Bacteriophages are traditionally used for the development of phage display technology. Recently, their nanosized dimensions and ease with which genetic modifications can be made to their structure and function have put them in the spotlight towards their use in a variety of biosensors. In particular, the expression of any protein or peptide on the extraluminal surface of bacteriophages is possible by genetically engineering the genome. In addition, the relatively short replication time of bacteriophages offers researchers the ability to generate mass quantities of any given bacteriophage-based biosensor. Coupled with the emergence of various biomarkers in the clinic as a means to determine pathophysiological states, the development of current and novel technologies for their detection and quantification is imperative. In this review, we categorize bacteriophages by their morphology into M13-based filamentous bacteriophages and T4- or T7-based icosahedral bacteriophages, and examine how such advantages are utilized across a variety of biosensors. In essence, we take a comprehensive approach towards recent trends in bacteriophage-based biosensor applications and discuss their outlook with regards to the field of biotechnology. Keywords: biosensing, M13 bacteriophage, T4 bacteriophage, bacterial detection, Escherichia coli, SPR sensor

  13. Complete Genome Sequences of Five Bacteriophages That Infect Rhodobacter capsulatus.

    Science.gov (United States)

    Bollivar, David W; Bernardoni, Brooke; Bockman, Matthew R; Miller, Brenda M; Russell, Daniel A; Delesalle, Veronique A; Krukonis, Gregory P; Hatfull, Graham F; Cross, Madeline R; Szewczyk, Marlena M; Eppurath, Atul

    2016-05-26

    Five bacteriophages that infect the Rhodobacter capsulatus strain YW1 were isolated from stream water near Bloomington, Illinois, USA. Two distinct genome types are represented in the newly isolated bacteriophages. These genomes are different from other bacteriophage genomes previously described.

  14. Programming Language Concepts - The Lambda Calculus Approach

    NARCIS (Netherlands)

    Fokkinga, Maarten M.; Asveld, P.R.J.; Nijholt, A.

    1987-01-01

    The Lambda Calculus is a formal system, originally intended as a tool in the foundation of mathematics, but mainly used to study the concepts of algorithm and effective computability. Recently, the Lambda Calculus and related systems acquire attention from Computer Science for another reason too: s

  15. Primary structure and functional analysis of the lysis genes of Lactobacillus gasseri bacteriophage phi adh.

    OpenAIRE

    Henrich, B; Binishofer, B; Bläsi, U

    1995-01-01

    The lysis genes of the Lactobacillus gasseri bacteriophage phi adh were isolated by complementation of a lambda Sam mutation in Escherichia coli. Nucleotide sequencing of a 1,735-bp DNA fragment revealed two adjacent coding regions of 342 bp (hol) and 951 bp (lys) in the same reading frame which appear to belong to a common transcriptional unit. Proteins corresponding to the predicted gene products, holin (12.9 kDa) and lysin (34.7 kDa), were identified by in vitro and in vivo expression of t...

  16. Measurement of the {Lambda}{sub b} cross section and the {Lambda}{sup Macron }{sub b} to {Lambda}{sub b} ratio with J/{psi}{Lambda} decays in pp collisions at {radical}(s)=7 TeV

    Energy Technology Data Exchange (ETDEWEB)

    Chatrchyan, S.; Khachatryan, V.; Sirunyan, A.M.; Tumasyan, A. [Yerevan Physics Institute, Yerevan (Armenia); Adam, W.; Bergauer, T.; Dragicevic, M.; Eroe, J.; Fabjan, C.; Friedl, M.; Fruehwirth, R.; Ghete, V.M.; Hammer, J.; Hoermann, N.; Hrubec, J.; Jeitler, M.; Kiesenhofer, W.; Knuenz, V.; Krammer, M.; Liko, D. [Institut fuer Hochenergiephysik der OeAW, Wien (Austria); and others

    2012-08-14

    The {Lambda}{sub b} differential production cross section and the cross section ratio {sigma}({Lambda}{sup Macron }{sub b})/{sigma}({Lambda}{sub b}) are measured as functions of transverse momentum p{sub T}{sup {Lambda}{sub b}} and rapidity |y{sup {Lambda}{sub b}}| in pp collisions at {radical}(s)=7 TeV using data collected by the CMS experiment at the LHC. The measurements are based on {Lambda}{sub b} decays reconstructed in the exclusive final state J/{psi}{Lambda}, with the subsequent decays J/{psi}{yields}{mu}{sup +}{mu}{sup -} and {Lambda}{yields}p{pi}, using a data sample corresponding to an integrated luminosity of 1.9 fb{sup -1}. The product {sigma}({Lambda}{sub b}) Multiplication-Sign B({Lambda}{sub b}{yields}J/{psi}{Lambda}) versus p{sub T}{sup {Lambda}{sub b}} falls faster than that of b mesons. The measured value of {sigma}({Lambda}{sub b}) Multiplication-Sign B({Lambda}{sub b}{yields}J/{psi}{Lambda}) for p{sub T}{sup {Lambda}{sub b}}>10 GeV and |y{sup {Lambda}{sub b}}|<2.0 is 1.16{+-}0.06{+-}0.12 nb, and the integrated {sigma}({Lambda}{sup Macron }{sub b})/{sigma}({Lambda}{sub b}) ratio is 1.02{+-}0.07{+-}0.09, where the uncertainties are statistical and systematic, respectively.

  17. Single molecule studies of DNA packaging by bacteriophages

    Science.gov (United States)

    Fuller, Derek Nathan

    The DNA packaging dynamics of bacteriophages φ29, gamma, and T4 were studied at the single molecule level using a dual trap optical tweezers. Also, a method for producing long DNA molecules by PCR for optical tweezers studies of protein DNA interactions is presented and thoroughly characterized. This DNA preparation technique provided DNA samples for the φ29 and T4 studies. In the studies of φ29, the role of charge was investigated by varying the ionic conditions of the packaging buffer. Ionic conditions in which the DNA charge was highly screened due to divalent and trivalent cations showed the lowest resistance to packaging of the DNA to high density. This confirmed the importance of counterions in shielding the DNA interstrand repulsion when packaged to high density. While the ionic nature of the packaging buffer had a strong effect on packaging velocities, there was no clear trend between the counterion-screened charge of the DNA and the maximum packaging velocity. The packaging studies of lambda and T4 served as systems for comparative studies with φ29. Each system showed similarities to the φ29 system and unique differences. Both the lambda and T4 packaging motors were capable of generating forces in excess of 50 pN and showed remarkably high processivity, similar to φ29. However, dynamic structural transitions were observed with lambda that are not observed with φ29. The packaging of the lambda genome showed capsid expansion at approximately 30 percent of the genome packaged and capsid rupture at 90 percent of the genome packaged in the absence of capsid stabilizing protein gpD. Unique to the T4 packaging motor, packaging dynamics showed a remarkable amount of variability in velocities. This variability was seen both within individual packaging phages and from one phage to the next. This is possibly due to different conformational states of the packaging machinery. Additionally, lambda and T4 had average packaging velocities under minimal load of 600

  18. $\\Lambda_b \\to \\pi^- (D_s^-) \\Lambda_c(2595),~\\pi^- (D_s^-) \\Lambda_c(2625)$ decays and $DN,~D^*N$ molecular components

    CERN Document Server

    Liang, Wei-Hong; Oset, E

    2016-01-01

    From the perspective that the $\\Lambda_c(2595)$ and $\\Lambda_c(2625)$ are dynamically generated resonances from the $DN,~D^*N$ interaction and coupled channels, we have evaluated the rates for $\\Lambda_b \\to \\pi^- \\Lambda_c(2595)$ and $\\Lambda_b \\to \\pi^- \\Lambda_c(2625)$ up to a global unknown factor that allows us to calculate the ratio of rates and compare with experiment, where good agreement is found. Similarly, we can also make predictions for the ratio of rates of the, yet unknown, decays of $\\Lambda_b \\to D_s^- \\Lambda_c(2595)$ and $\\Lambda_b \\to D_s^- \\Lambda_c(2625)$ and make estimates for their individual branching fractions.

  19. Predictions for nonleptonic Lambda_b and Theta_b

    CERN Document Server

    Leibovich, A K; Stewart, I W; Wise, M B; Leibovich, Adam K.; Ligeti, Zoltan; Stewart, Iain W.; Wise, Mark B.

    2003-01-01

    We study nonleptonic Lambda_b -> Lambda_c pi, Sigma_c pi and Sigma_c^* pi decays in limit m_b, m_c, E_pi >> Lambda_{QCD} using the soft-collinear effective theory. Here Sigma_c = Sigma_c(2455) and Sigma_c^* = Sigma_c(2520). At leading order the Lambda_b -> Sigma_c^{(*)} pi rates vanish, while the Lambda_b -> Lambda_c pi rate is related to Lambda_b -> Lambda_c\\ell\\bar\

  20. Lambda-Lifting in Quadratic Time

    DEFF Research Database (Denmark)

    Danvy, Olivier; Schultz, Ulrik Pagh

    2003-01-01

    Lambda-lifting is a program transformation that is used in compilers, partial evaluators, and program transformers. In this article, we show how to reduce its complexity from cubic time to quadratic time, and we present a flow-sensitive lambda-lifter that also works in quadratic time. Lambda...... on the simple observation that all functions in each component need the same extra parameters and thus a transitive closure is not needed. We therefore simplify the search for extra parameters by treating each strongly connected component instead of each function as a unit, thereby reducing the time complexity...

  1. Lambda-lifting in Quadratic Time

    DEFF Research Database (Denmark)

    Danvy, O.; Schultz, U.P.

    2004-01-01

    Lambda-lifting is a program transformation that is used in compilers, partial evaluators, and program transformers. In this article, we show how to reduce its complexity from cubic time to quadratic time, and we present a flow-sensitive lambda-lifter that also works in quadratic time. Lambda...... on the simple observation that all functions in each component need the same extra parameters and thus a transitive closure is not needed. We therefore simplify the search for extra parameters by treating each strongly connected component instead of each function as a unit, thereby reducing the time complexity...

  2. Running vacuum versus the $\\Lambda$CDM

    CERN Document Server

    Gómez-Valent, Adrià; Pérez, Javier de Cruz

    2016-01-01

    It is well-known that a constant $\\Lambda$-term is a traditional building block of the concordance $\\Lambda$CDM model. We show that this assumption is not necessarily the optimal one from the phenomenological point of view. The class of running vacuum models, with a possible running of the gravitational coupling G, are capable to fit the overall cosmological data SNIa+BAO+H(z)+LSS+BBN+CMB better than the $\\Lambda$CDM, namely at a level of $\\sim 3\\sigma$ and with Akaike and Bayesian information criteria supporting a strong level of statistical evidence on this fact. Here we report on the results of such analysis.

  3. Bacteriophage Procurement for Therapeutic Purposes.

    Science.gov (United States)

    Weber-Dąbrowska, Beata; Jończyk-Matysiak, Ewa; Żaczek, Maciej; Łobocka, Małgorzata; Łusiak-Szelachowska, Marzanna; Górski, Andrzej

    2016-01-01

    Bacteriophages (phages), discovered 100 years ago, are able to infect and destroy only bacterial cells. In the current crisis of antibiotic efficacy, phage therapy is considered as a supplementary or even alternative therapeutic approach. Evolution of multidrug-resistant and pandrug-resistant bacterial strains poses a real threat, so it is extremely important to have the possibility to isolate new phages for therapeutic purposes. Our phage laboratory and therapy center has extensive experience with phage isolation, characterization, and therapeutic application. In this article we present current progress in bacteriophages isolation and use for therapeutic purposes, our experience in this field and its practical implications for phage therapy. We attempt to summarize the state of the art: properties of phages, the methods for their isolation, criteria of phage selection for therapeutic purposes and limitations of their use. Perspectives for the use of genetically engineered phages to specifically target bacterial virulence-associated genes are also briefly presented. PMID:27570518

  4. Bacteriophage biocontrol of foodborne pathogens.

    Science.gov (United States)

    Kazi, Mustafa; Annapure, Uday S

    2016-03-01

    Bacteriophages are viruses that only infect bacterial cells. Phages are categorized based on the type of their life cycle, the lytic cycle cause lysis of the bacterium with the release of multiple phage particles where as in lysogenic phase the phage DNA is incorporated into the bacterial genome. Lysogeny does not result in lysis of the host. Lytic phages have several potential applications in the food industry as biocontrol agents, biopreservatives and as tools for detecting pathogens. They have also been proposed as alternatives to antibiotics in animal health. Two unique features of phage relevant for food safety are that they are harmless to mammalian cells and high host specificity, keeping the natural microbiota undisturbed. However, the recent approval of bacteriophages as food additives has opened the discussion about 'edible viruses'. This article reviews in detail the application of phages for the control of foodborne pathogens in a process known as "biocontrol". PMID:27570260

  5. uv induced enhancement of recombination among lambda bacteriophages: relation with replication of irradiated DNA

    Energy Technology Data Exchange (ETDEWEB)

    Cordone, L.; Sperandeo-Mineo, R.M.; Mannino, S.

    1975-07-01

    Experimental results are reported showing the dependence of the uv induced enhancement of recombinants on the presence of the functional O gene product. This fact is tentatively interpreted as a replication dependence of the uv induced recombination.

  6. A forward-genetic screen and dynamic analysis of lambda phage host-dependencies reveals an extensive interaction network and a new anti-viral strategy.

    Directory of Open Access Journals (Sweden)

    Nathaniel D Maynard

    2010-07-01

    Full Text Available Latently infecting viruses are an important class of virus that plays a key role in viral evolution and human health. Here we report a genome-scale forward-genetics screen for host-dependencies of the latently-infecting bacteriophage lambda. This screen identified 57 Escherichia coli (E. coli genes--over half of which have not been previously associated with infection--that when knocked out inhibited lambda phage's ability to replicate. Our results demonstrate a highly integrated network between lambda and its host, in striking contrast to the results from a similar screen using the lytic-only infecting T7 virus. We then measured the growth of E. coli under normal and infected conditions, using wild-type and knockout strains deficient in one of the identified host genes, and found that genes from the same pathway often exhibited similar growth dynamics. This observation, combined with further computational and experimental analysis, led us to identify a previously unannotated gene, yneJ, as a novel regulator of lamB gene expression. A surprising result of this work was the identification of two highly conserved pathways involved in tRNA thiolation-one pathway is required for efficient lambda replication, while the other has anti-viral properties inhibiting lambda replication. Based on our data, it appears that 2-thiouridine modification of tRNAGlu, tRNAGln, and tRNALys is particularly important for the efficient production of infectious lambda phage particles.

  7. Variable cosmological term $\\Lambda(t)$

    CERN Document Server

    Socorro, J; Pimentel, Luis O

    2015-01-01

    We present the case of time-varying cosmological term $\\Lambda(t)$. The main idea arises by proposing that as in the cosmological constant case, the scalar potential is identified as $ V(\\phi)=2\\Lambda$, with $\\Lambda$ a constant, this identification should be kept even when the cosmological term has a temporal dependence, i.e., $ V(\\phi(t))=2\\Lambda(t)$. We Use the Lagrangian formalism for a scalar field $\\phi$ with standard kinetic energy and arbitrary potential $V(\\phi)$ and apply this model to the Friedmann-Robertson-Walker (FRW)cosmology. Exact solutions of the field equations are obtained by a special ansatz to solve the Einstein-Klein-Gordon equation and a particular potential for the scalar field and barotropic perfect fluid. We present the evolution on this cosmological term with different scenarios.

  8. Variable cosmological term \\varLambda(t)

    Science.gov (United States)

    Socorro, J.; D'oleire, M.; Pimentel, Luis O.

    2015-11-01

    We present the case of time-varying cosmological term \\varLambda(t). The main idea arises by proposing that as in the cosmological constant case, the scalar potential is identified as V(φ)=2\\varLambda, with \\varLambda a constant, this identification should be kept even when the cosmological term has a temporal dependence, i.e., V(φ(t))=2\\varLambda(t). We use the Lagrangian formalism for a scalar field φ with standard kinetic energy and arbitrary potential V(φ) and apply this model to the Friedmann-Robertson-Walker (FRW) cosmology. Exact solutions of the field equations are obtained by a special ansatz to solve the Einstein-Klein-Gordon equation and a particular potential for the scalar field and barotropic perfect fluid. We present the evolution on this cosmological term with different scenarios.

  9. Time Dependent Analysis of Decays $\\Lambda_{b} \\to \\Lambda + D^{0}$ and $\\Lambda_{b} \\to \\Lambda +\\overline{D}^{0}$

    CERN Document Server

    Fayyazuddin, A

    2000-01-01

    The time-dependent analysis of the decays $\\Lambda_b\\to \\Lambda +D^0(t)$ and $\\Lambda_b\\to \\Lambda +\\bar{D}^0(t)$ is discussed. The effect of particle mixing due to time evolution of $D^0$ and $\\bar{D}^0$ on the observables for these decays viz the branching ratio of decay widths and the asymmetry parameters $\\alpha ,\\beta$ and $\\gamma$ are analysed. It is shown that it is possible to extract information about $(\\Delta m/\\Gamma)\\sin \\hat{\\gamma}$ from the experimental data for these observables. Here $\\Delta m=m_{D_1^0}-m_{D_2^0},\\Gamma$ is the decay widths for $D^{\\prime}s$ and $\\hat{\\gamma}$ is the weak phase.

  10. LambdaSa1 and LambdaSa2 Prophage Lysins of Streptococcus agalactiae▿

    OpenAIRE

    Pritchard, David G.; Dong, Shengli; Kirk, Marion C.; Cartee, Robert T.; Baker, John R.

    2007-01-01

    Putative N-acetylmuramyl-l-alanine amidase genes from LambdaSa1 and LambdaSa2 prophages of Streptococcus agalactiae were cloned and expressed in Escherichia coli. The purified enzymes lysed the cell walls of Streptococcus agalactiae, Streptococcus pneumoniae, and Staphylococcus aureus. The peptidoglycan digestion products in the cell wall lysates were not consistent with amidase activity. Instead, the structure of the muropeptide digestion fragments indicated that both the LambdaSa1 and Lambd...

  11. Lambda Exonuclease Digestion of CGG Trinucleotide Repeats

    OpenAIRE

    Conroy, R. S.; Koretsky, A P; Moreland, J.

    2009-01-01

    Fragile X syndrome and other triplet repeat diseases are characterized by an elongation of a repeating DNA triplet. The ensemble-averaged lambda exonuclease digestion rate of different substrates, including one with an elongated FMR1 gene containing 120 CGG repeats, was measured using absorption and fluorescence spectroscopy. Using magnetic tweezers sequence-dependent digestion rates and pausing was measured for individual lambda exonucleases. Within the triplet repeats a lower average and na...

  12. Use of Bacteriophages to control bacterial pathogens

    Science.gov (United States)

    Lytic bacteriophages can provide a natural method and an effective alternative to antibiotics to reduce bacterial pathogens in animals, foods, and other environments. Bacteriophages (phages) are viruses which infect bacterial cells and eventually kill them through lysis, and represent the most abun...

  13. Programming Bacteriophages by Swapping Their Specificity Determinants.

    Science.gov (United States)

    Goren, Moran G; Yosef, Ido; Qimron, Udi

    2015-12-01

    Bacteriophages, bacteria's natural enemies, may serve as potent antibacterial agents. Their specificity for certain bacterial sub-species limits their effectiveness, but allows selective targeting of bacteria. Lu and colleagues present a platform for such targeting through alteration of bacteriophages' host specificity by swapping specificity domains in their host-recognition ligand.

  14. Nanoscale bacteriophage biosensors beyond phage display.

    Science.gov (United States)

    Lee, Jong-Wook; Song, Jangwon; Hwang, Mintai P; Lee, Kwan Hyi

    2013-01-01

    Bacteriophages are traditionally used for the development of phage display technology. Recently, their nanosized dimensions and ease with which genetic modifications can be made to their structure and function have put them in the spotlight towards their use in a variety of biosensors. In particular, the expression of any protein or peptide on the extraluminal surface of bacteriophages is possible by genetically engineering the genome. In addition, the relatively short replication time of bacteriophages offers researchers the ability to generate mass quantities of any given bacteriophage-based biosensor. Coupled with the emergence of various biomarkers in the clinic as a means to determine pathophysiological states, the development of current and novel technologies for their detection and quantification is imperative. In this review, we categorize bacteriophages by their morphology into M13-based filamentous bacteriophages and T4- or T7-based icosahedral bacteriophages, and examine how such advantages are utilized across a variety of biosensors. In essence, we take a comprehensive approach towards recent trends in bacteriophage-based biosensor applications and discuss their outlook with regards to the field of biotechnology.

  15. Lambda_b -> Lambda l+ l- form factors and differential branching fraction from lattice QCD

    OpenAIRE

    Detmold, William; Lin, C. -J. David; Meinel, Stefan; Wingate, Matthew

    2012-01-01

    We present the first lattice QCD determination of the $\\Lambda_b \\to \\Lambda$ transition form factors that govern the rare baryonic decays $\\Lambda_b \\to \\Lambda l^+ l^-$ at leading order in heavy-quark effective theory. Our calculations are performed with 2+1 flavors of domain-wall fermions, at two lattice spacings and with pion masses down to 227 MeV. Three-point functions with a wide range of source-sink separations are used to extract the ground-state contributions. The form factors are e...

  16. Study ofe+e- to Lambda anti-Lambda, Lambda anti-Sigma^0,Sigma^0 anti-Sigma^0 using Initial State Radiation with BaBar

    Energy Technology Data Exchange (ETDEWEB)

    Aubert, B.

    2007-09-14

    We study the e+e- --> Lambda anti-Lambda gamma, Lambda anti-Sigma0 gamma, Sigma0 anti-Sigma0 gamma processes using 230 fb-1 of integrated luminosity collected by the BaBar detector at e+e- center-of-mass energy of 10.58 GeV. From the analysis of the baryon-antibaryon mass spectra the cross sections for e+e- --> Lambda anti-Lambda, Lambda anti-Sigma0, Sigma0 anti-Sigma0 are measured in the dibaryon mass range from threshold up to 3 GeV/c{sup 2}. The ratio of electric and magnetic form factors, |G{sub E}/G{sub M}|, is measured for e+e- --> Lambda anti-Lambda, and limits on the relative phase between Lambda form factors are obtained. We also measure the J/psi --> Lambda anti-Lambda, Sigma0 anti-Sigma0 and psi(2S) --> Lambda anti-Lambda branching fractions.

  17. Measurement of Lambda and Lambda-bar polarization in muon neutrino charged current interactions in NOMAD

    CERN Document Server

    Naumov, D V

    2002-01-01

    The Lambda and Lambda-bar polarizations in muon neutrino charged current interactions have been measured in the NOMAD experiment. The event sample (8087 reconstructed Lambda's and 649 Lambda-bar's) is more than an order of magnitude larger than that of previous bubble chamber experiments, while the quality of event reconstruction is comparable. For the Lambda hyperons we observe negative polarization along the W-boson direction which is enhanced in the target fragmentation region: Px(xF 0) = -0.09 +- 0.06 (stat) +- 0.03(sys). A significant transverse polarization (in the direction orthogonal to the Lambda production plane) has been observed for the first time in a neutrino experiment: Py = -0.22 +- 0.03 (stat) +- 0.01 (sys). The dependence of the absolute value of Py on the Lambda transverse momentum with respect to the hadronic jet direction is in qualitative agreement with the results from unpolarized hadron-hadron experiments. The polarization vector of Lambda-bar hyperons measured for the first time in n...

  18. Observation of chi(cJ) decays to Lambda(Lambda)over-bar pi(+)pi(-)

    NARCIS (Netherlands)

    Ablikim, M.; Achasov, M. N.; Ambrose, D. J.; An, F. F.; An, Q.; An, Z. H.; Bai, J. Z.; Ban, Y.; Becker, J.; Bennett, J. V.; Bertani, M.; Bian, J. M.; Boger, E.; Bondarenko, O.; Boyko, I.; Briere, R. A.; Bytev, V.; Cai, X.; Cakir, O.; Calcaterra, A.; Cao, G. F.; Cetin, S. A.; Chang, J. F.; Chelkov, G.; Chen, G.; Chen, H. S.; Chen, J. C.; Chen, M. L.; Chen, S. J.; Chen, Y. B.; Cheng, H. P.; Chu, Y. P.; Cronin-Hennessy, D.; Dai, H. L.; Dai, J. P.; Dedovich, D.; Deng, Z. Y.; Denig, A.; Denysenko, I.; Destefanis, M.; Ding, W. M.; Ding, Y.; Dong, L. Y.; Dong, M. Y.; Du, S. X.; Fang, J.; Fang, S. S.; Fava, L.; Feldbauer, F.; Feng, C. Q.; Ferroli, R. B.; Fu, C. D.; Fu, J. L.; Gao, Y.; Geng, C.; Goetzen, K.; Gong, W. X.; Gradl, W.; Greco, M.; Gu, M. H.; Gu, Y. T.; Guan, Y. H.; Guo, A. Q.; Guo, L. B.; Guo, Y. P.; Han, Y. L.; Harris, F. A.; He, K. L.; He, M.; He, Z. Y.; Held, T.; Heng, Y. K.; Hou, Z. L.; Hu, H. M.; Hu, J. F.; Hu, T.; Huang, G. M.; Huang, J. S.; Huang, X. T.; Huang, Y. P.; Hussain, T.; Ji, C. S.; Ji, Q.; Ji, X. B.; Ji, X. L.; Jiang, L. L.; Jiang, X. S.; Jiao, J. B.; Jiao, Z.; Jin, D. P.; Jin, S.; Jing, F. F.; Kalantar-Nayestanaki, N.; Kavatsyuk, M.; Kuehn, W.; Lai, W.; Lange, J. S.; Li, C. H.; Li, Cheng; Li, Cui; Li, D. M.; Li, F.; Li, G.; Li, H. B.; Li, J. C.; Li, K.; Li, Lei; Li, Q. J.; Li, S. L.; Li, W. D.; Li, W. G.; Li, X. L.; Li, X. N.; Li, X. Q.; Li, X. R.; Li, Z. B.; Liang, H.; Liang, Y. F.; Liang, Y. T.; Liao, G. R.; Liao, X. T.; Liu, B. J.; Liu, C. L.; Liu, C. X.; Liu, C. Y.; Liu, F. H.; Liu, Fang; Liu, Feng; Liu, H.; Liu, H. B.; Liu, H. H.; Liu, H. M.; Liu, H. W.; Liu, J. P.; Liu, K. Y.; Liu, Kai; Liu, P. L.; Liu, Q.; Liu, S. B.; Liu, X.; Liu, X. H.; Liu, Y. B.; Liu, Z. A.; Liu, Zhiqiang; Liu, Zhiqing; Loehner, H.; Lu, G. R.; Lu, H. J.; Lu, J. G.; Lu, Q. W.; Lu, X. R.; Lu, Y. P.; Luo, C. L.; Luo, M. X.; Luo, T.; Luo, X. L.; Lv, M.; Ma, C. L.; Ma, F. C.; Ma, H. L.; Ma, Q. M.; Ma, S.; Ma, T.; Ma, X. Y.; Ma, Y.; Maas, F. E.; Maggiora, M.; Malik, Q. A.; Mao, Y. J.; Mao, Z. P.; Messchendorp, J. G.; Min, J.; Min, T. J.; Mitchell, R. E.; Mo, X. H.; Morales, C. Morales; Motzko, C.; Muchnoi, N. Yu.; Muramatsu, H.; Nefedov, Y.; Nicholson, C.; Nikolaev, I. B.; Ning, Z.; Olsen, S. L.; Ouyang, Q.; Pacetti, S.; Park, J. W.; Pelizaeus, M.; Peng, H. P.; Peters, K.; Ping, J. L.; Ping, R. G.; Poling, R.; Prencipe, E.; Qi, M.; Qian, S.; Qiao, C. F.; Qin, X. S.; Qin, Y.; Qin, Z. H.; Qiu, J. F.; Rashid, K. H.; Rong, G.; Ruan, X. D.; Sarantsev, A.; Schaefer, B. D.; Schulze, J.; Shao, M.; Shen, C. P.; Shen, X. Y.; Sheng, H. Y.; Shepherd, M. R.; Song, X. Y.; Spataro, S.; Spruck, B.; Sun, D. H.; Sun, G. X.; Sun, J. F.; Sun, S. S.; Sun, Y. J.; Sun, Y. Z.; Sun, Z. J.; Sun, Z. T.; Tang, C. J.; Tang, X.; Tapan, I.; Thorndike, E. H.; Toth, D.; Ullrich, M.; Varner, G. S.; Wang, B.; Wang, B. Q.; Wang, K.; Wang, L. L.; Wang, L. S.; Wang, M.; Wang, P.; Wang, P. L.; Wang, Q.; Wang, Q. J.; Wang, S. G.; Wang, X. L.; Wang, Y. D.; Wang, Y. F.; Wang, Y. Q.; Wang, Z.; Wang, Z. G.; Wang, Z. Y.; Wei, D. H.; Weidenkaff, P.; Wen, Q. G.; Wen, S. P.; Wiedner, U.; Wu, L. H.; Wu, N.; Wu, S. X.; Wu, W.; Wu, Z.; Xia, L. G.; Xiao, Z. J.; Xie, Y. G.; Xiu, Q. L.; Xu, G. F.; Xu, G. M.; Xu, H.; Xu, Q. J.; Xu, X. P.; Xu, Z. R.; Xue, F.; Xue, Z.; Yan, L.; Yan, W. B.; Yan, Y. H.; Yang, H. X.; Yang, Y.; Yang, Y. X.; Ye, H.; Ye, M.; Ye, M. H.; Yu, B. X.; Yu, C. X.; Yu, J. S.; Yu, S. P.; Yuan, C. Z.; Yuan, Y.; Zafar, A. A.; Zallo, A.; Zeng, Y.; Zhang, B. X.; Zhang, B. Y.; Zhang, C. C.; Zhang, D. H.; Zhang, H. H.; Zhang, H. Y.; Zhang, J. Q.; Zhang, J. W.; Zhang, J. Y.; Zhang, J. Z.; Zhang, S. H.; Zhang, X. J.; Zhang, X. Y.; Zhang, Y.; Zhang, Y. H.; Zhang, Y. S.; Zhang, Z. P.; Zhang, Z. Y.; Zhao, G.; Zhao, H. S.; Zhao, J. W.; Zhao, K. X.; Zhao, Lei; Zhao, Ling; Zhao, M. G.; Zhao, Q.; Zhao, S. J.; Zhao, T. C.; Zhao, X. H.; Zhao, Y. B.; Zhao, Z. G.; Zhemchugov, A.; Zheng, B.; Zheng, Y. H.; Zhong, B.; Zhong, J.; Zhou, L.; Zhou, X. K.; Zhou, X. R.; Zhu, C.; Zhu, K.; Zhu, K. J.; Zhu, S. H.; Zhu, X. L.; Zhu, X. W.; Zhu, Y. C.; Zhu, Y. M.; Zhu, Y. S.; Zhu, Z. A.; Zhuang, J.; Zou, B. S.; Zou, J. H.; Werner, M.J.; Zheng, J.P.

    2012-01-01

    Decays of the chi(cJ) states (J = 0, 1, 2) to Lambda(Lambda) over bar pi(+)pi(-), including processes with intermediate Sigma(1385), are studied through the E1 transition psi(1) -> gamma chi(cJ) using 106 x 10(6) psi(1) events collected with the BESIII detector at BEPCII. This is the first observati

  19. Asymmetries and observables for $\\Lambda_b\\rightarrow \\Lambda \\ell^+\\ell^-$

    CERN Document Server

    Kumar, Girish

    2015-01-01

    The semi-leptonic baryonic $b\\to s$ decay, $\\Lambda_b\\rightarrow \\Lambda \\ell^+\\ell^-$, has been studied and new angular observables and asymmetries have been proposed which can test the presence of new physics beyond the standard model.

  20. Spectrum of class-M supergiants in the region lambda lambda 7000-6000 angstrom

    Science.gov (United States)

    Orlov, M. Y.; Rodriguez, M. H.; Shavrina, A. V.

    1973-01-01

    A general description is given of the spectrum of four M-supergiants in the region lambda lambda 7000-6000 A from high-dispersion spectrograms (6 A/mm). The equivalent widths of several hundred lines and depths of some molecular band heads were measured.

  1. Two bacteriophages of Clostridium difficile.

    OpenAIRE

    Mahony, D E; Bell, P D; Easterbrook, K. B.

    1985-01-01

    Two temperate bacteriophages of differing morphology and host range were isolated by screening 94 isolates of Clostridium difficile. Phage 41 had a 300-nm flexible tail, whereas phage 56 had a shorter tail with a contractile sheath. Electron microscopy of phage 56 lysates exposed to elevated magnesium concentrations showed small virus-like particles which were 21 nm in diameter. The addition of MgCl2 to semisolid agar overlays enhanced both the titer and plaque size of phage 56. Phage 56 was ...

  2. Measurement of the $\\Lambda_b$ cross section and the $\\overline{\\Lambda}_b$ to $\\Lambda_b$ ratio with J/$\\psi\\Lambda$ decays in pp collisions at $\\sqrt{s}$ = 7 TeV

    CERN Document Server

    Chatrchyan, Serguei; Sirunyan, Albert M; Tumasyan, Armen; Adam, Wolfgang; Bergauer, Thomas; Dragicevic, Marko; Erö, Janos; Fabjan, Christian; Friedl, Markus; Fruehwirth, Rudolf; Ghete, Vasile Mihai; Hammer, Josef; Hörmann, Natascha; Hrubec, Josef; Jeitler, Manfred; Kiesenhofer, Wolfgang; Knünz, Valentin; Krammer, Manfred; Liko, Dietrich; Mikulec, Ivan; Pernicka, Manfred; Rahbaran, Babak; Rohringer, Christine; Rohringer, Herbert; Schöfbeck, Robert; Strauss, Josef; Taurok, Anton; Wagner, Philipp; Waltenberger, Wolfgang; Walzel, Gerhard; Widl, Edmund; Wulz, Claudia-Elisabeth; Mossolov, Vladimir; Shumeiko, Nikolai; Suarez Gonzalez, Juan; Bansal, Sunil; Cornelis, Tom; De Wolf, Eddi A; Janssen, Xavier; Luyckx, Sten; Maes, Thomas; Mucibello, Luca; Ochesanu, Silvia; Roland, Benoit; Rougny, Romain; Selvaggi, Michele; Staykova, Zlatka; Van Haevermaet, Hans; Van Mechelen, Pierre; Van Remortel, Nick; Van Spilbeeck, Alex; Blekman, Freya; Blyweert, Stijn; D'Hondt, Jorgen; Gonzalez Suarez, Rebeca; Kalogeropoulos, Alexis; Maes, Michael; Olbrechts, Annik; Van Doninck, Walter; Van Mulders, Petra; Van Onsem, Gerrit Patrick; Villella, Ilaria; Charaf, Otman; Clerbaux, Barbara; De Lentdecker, Gilles; Dero, Vincent; Gay, Arnaud; Hreus, Tomas; Léonard, Alexandre; Marage, Pierre Edouard; Reis, Thomas; Thomas, Laurent; Vander Velde, Catherine; Vanlaer, Pascal; Wang, Jian; Adler, Volker; Beernaert, Kelly; Cimmino, Anna; Costantini, Silvia; Garcia, Guillaume; Grunewald, Martin; Klein, Benjamin; Lellouch, Jérémie; Marinov, Andrey; Mccartin, Joseph; Ocampo Rios, Alberto Andres; Ryckbosch, Dirk; Strobbe, Nadja; Thyssen, Filip; Tytgat, Michael; Vanelderen, Lukas; Verwilligen, Piet; Walsh, Sinead; Yazgan, Efe; Zaganidis, Nicolas; Basegmez, Suzan; Bruno, Giacomo; Castello, Roberto; Ceard, Ludivine; Delaere, Christophe; Du Pree, Tristan; Favart, Denis; Forthomme, Laurent; Giammanco, Andrea; Hollar, Jonathan; Lemaitre, Vincent; Liao, Junhui; Militaru, Otilia; Nuttens, Claude; Pagano, Davide; Pin, Arnaud; Piotrzkowski, Krzysztof; Schul, Nicolas; Vizan Garcia, Jesus Manuel; Beliy, Nikita; Caebergs, Thierry; Daubie, Evelyne; Hammad, Gregory Habib; Alves, Gilvan; Correa Martins Junior, Marcos; De Jesus Damiao, Dilson; Martins, Thiago; Pol, Maria Elena; Henrique Gomes E Souza, Moacyr; Aldá Júnior, Walter Luiz; Carvalho, Wagner; Custódio, Analu; Da Costa, Eliza Melo; De Oliveira Martins, Carley; Fonseca De Souza, Sandro; Matos Figueiredo, Diego; Mundim, Luiz; Nogima, Helio; Oguri, Vitor; Prado Da Silva, Wanda Lucia; Santoro, Alberto; Soares Jorge, Luana; Sznajder, Andre; Bernardes, Cesar Augusto; De Almeida Dias, Flavia; Tomei, Thiago; De Moraes Gregores, Eduardo; Lagana, Caio; Da Cunha Marinho, Franciole; Mercadante, Pedro G; Novaes, Sergio F; Padula, Sandra; Genchev, Vladimir; Iaydjiev, Plamen; Piperov, Stefan; Rodozov, Mircho; Stoykova, Stefka; Sultanov, Georgi; Tcholakov, Vanio; Trayanov, Rumen; Vutova, Mariana; Dimitrov, Anton; Hadjiiska, Roumyana; Kozhuharov, Venelin; Litov, Leander; Pavlov, Borislav; Petkov, Peicho; Bian, Jian-Guo; Chen, Guo-Ming; Chen, He-Sheng; Jiang, Chun-Hua; Liang, Dong; Liang, Song; Meng, Xiangwei; Tao, Junquan; Wang, Jian; Wang, Xianyou; Wang, Zheng; Xiao, Hong; Xu, Ming; Zang, Jingjing; Zhang, Zhen; Asawatangtrakuldee, Chayanit; Ban, Yong; Guo, Shuang; Guo, Yifei; Li, Wenbo; Liu, Shuai; Mao, Yajun; Qian, Si-Jin; Teng, Haiyun; Wang, Siguang; Zhu, Bo; Zou, Wei; Avila, Carlos; Gomez, Juan Pablo; Gomez Moreno, Bernardo; Osorio Oliveros, Andres Felipe; Sanabria, Juan Carlos; Godinovic, Nikola; Lelas, Damir; Plestina, Roko; Polic, Dunja; Puljak, Ivica; Antunovic, Zeljko; Kovac, Marko; Brigljevic, Vuko; Duric, Senka; Kadija, Kreso; Luetic, Jelena; Morovic, Srecko; Attikis, Alexandros; Galanti, Mario; Mavromanolakis, Georgios; Mousa, Jehad; Nicolaou, Charalambos; Ptochos, Fotios; Razis, Panos A; Finger, Miroslav; Finger Jr, Michael; Assran, Yasser; Elgammal, Sherif; Ellithi Kamel, Ali; Khalil, Shaaban; Mahmoud, Mohammed; Radi, Amr; Kadastik, Mario; Müntel, Mait; Raidal, Martti; Rebane, Liis; Tiko, Andres; Azzolini, Virginia; Eerola, Paula; Fedi, Giacomo; Voutilainen, Mikko; Härkönen, Jaakko; Heikkinen, Mika Aatos; Karimäki, Veikko; Kinnunen, Ritva; Kortelainen, Matti J; Lampén, Tapio; Lassila-Perini, Kati; Lehti, Sami; Lindén, Tomas; Luukka, Panja-Riina; Mäenpää, Teppo; Peltola, Timo; Tuominen, Eija; Tuominiemi, Jorma; Tuovinen, Esa; Ungaro, Donatella; Wendland, Lauri; Banzuzi, Kukka; Korpela, Arja; Tuuva, Tuure; Besancon, Marc; Choudhury, Somnath; Dejardin, Marc; Denegri, Daniel; Fabbro, Bernard; Faure, Jean-Louis

    2012-01-01

    The Lambda(b) differential production cross section and the cross-section ratio for anti-Lambda(b)/Lambda(b) production are measured as functions of transverse momentum pt(Lambda(b)) and rapidity y(Lambda(b)) in pp collisions at sqrt(s) = 7 TeV using data collected by the CMS experiment at the LHC. The measurements are based on Lambda(b) decays reconstructed in the exclusive final state J/Psi Lambda, with the subsequent decays J/Psi to an opposite sign muon pair and Lambda to proton pion, using a data sample corresponding to an integrated luminosity of 1.9 inverse femtobarns. The product of the cross section times the branching ratio for Lambda(b) to J/Psi Lambda versus pt(Lambda(b)) falls faster than that of b mesons. The measured value of the cross section times the branching ratio for pt(Lambda(b)) > 10 GeV and abs(y(Lambda(b))) < 2.0 is 1.02 +/- 0.06 +/- 0.12 nb, and the integrated cross section ratio for anti-Lambda(b)/Lambda(b) is 1.02 +/- 0.07 +/- 0.09, where the uncertainties are statistical and sy...

  3. Measurement of the branching ratio $\\Gamma(\\Lambda_b^0 \\rightarrow \\psi(2S)\\Lambda^0)/\\Gamma(\\Lambda_b^0 \\rightarrow J/\\psi\\Lambda^0)$ with the ATLAS detector

    CERN Document Server

    Aad, Georges; Abdallah, Jalal; Abdinov, Ovsat; Aben, Rosemarie; Abolins, Maris; AbouZeid, Ossama; Abramowicz, Halina; Abreu, Henso; Abreu, Ricardo; Abulaiti, Yiming; Acharya, Bobby Samir; Adamczyk, Leszek; Adams, David; Adelman, Jahred; Adomeit, Stefanie; Adye, Tim; Affolder, Tony; Agatonovic-Jovin, Tatjana; Agricola, Johannes; Aguilar-Saavedra, Juan Antonio; Ahlen, Steven; Ahmadov, Faig; Aielli, Giulio; Akerstedt, Henrik; Åkesson, Torsten Paul Ake; Akimov, Andrei; Alberghi, Gian Luigi; Albert, Justin; Albrand, Solveig; Alconada Verzini, Maria Josefina; Aleksa, Martin; Aleksandrov, Igor; Alexa, Calin; Alexander, Gideon; Alexopoulos, Theodoros; Alhroob, Muhammad; Alimonti, Gianluca; Alio, Lion; Alison, John; Alkire, Steven Patrick; Allbrooke, Benedict; Allport, Phillip; Aloisio, Alberto; Alonso, Alejandro; Alonso, Francisco; Alpigiani, Cristiano; Altheimer, Andrew David; Alvarez Gonzalez, Barbara; Άlvarez Piqueras, Damián; Alviggi, Mariagrazia; Amadio, Brian Thomas; Amako, Katsuya; Amaral Coutinho, Yara; Amelung, Christoph; Amidei, Dante; Amor Dos Santos, Susana Patricia; Amorim, Antonio; Amoroso, Simone; Amram, Nir; Amundsen, Glenn; Anastopoulos, Christos; Ancu, Lucian Stefan; Andari, Nansi; Andeen, Timothy; Anders, Christoph Falk; Anders, Gabriel; Anders, John Kenneth; Anderson, Kelby; Andreazza, Attilio; Andrei, George Victor; Angelidakis, Stylianos; Angelozzi, Ivan; Anger, Philipp; Angerami, Aaron; Anghinolfi, Francis; Anisenkov, Alexey; Anjos, Nuno; Annovi, Alberto; Antonelli, Mario; Antonov, Alexey; Antos, Jaroslav; Anulli, Fabio; Aoki, Masato; Aperio Bella, Ludovica; Arabidze, Giorgi; Arai, Yasuo; Araque, Juan Pedro; Arce, Ayana; Arduh, Francisco Anuar; Arguin, Jean-Francois; Argyropoulos, Spyridon; Arik, Metin; Armbruster, Aaron James; Arnaez, Olivier; Arnal, Vanessa; Arnold, Hannah; Arratia, Miguel; Arslan, Ozan; Artamonov, Andrei; Artoni, Giacomo; Asai, Shoji; Asbah, Nedaa; Ashkenazi, Adi; Åsman, Barbro; Asquith, Lily; Assamagan, Ketevi; Astalos, Robert; Atkinson, Markus; Atlay, Naim Bora; Augsten, Kamil; Aurousseau, Mathieu; Avolio, Giuseppe; Axen, Bradley; Ayoub, Mohamad Kassem; Azuelos, Georges; Baak, Max; Baas, Alessandra; Baca, Matthew John; Bacci, Cesare; Bachacou, Henri; Bachas, Konstantinos; Backes, Moritz; Backhaus, Malte; Bagiacchi, Paolo; Bagnaia, Paolo; Bai, Yu; Bain, Travis; Baines, John; Baker, Oliver Keith; Baldin, Evgenii; Balek, Petr; Balestri, Thomas; Balli, Fabrice; Banas, Elzbieta; Banerjee, Swagato; Bannoura, Arwa A E; Bansil, Hardeep Singh; Barak, Liron; Barberio, Elisabetta Luigia; Barberis, Dario; Barbero, Marlon; Barillari, Teresa; Barisonzi, Marcello; Barklow, Timothy; Barlow, Nick; Barnes, Sarah Louise; Barnett, Bruce; Barnett, Michael; Barnovska, Zuzana; Baroncelli, Antonio; Barone, Gaetano; Barr, Alan; Barreiro, Fernando; Barreiro Guimarães da Costa, João; Bartoldus, Rainer; Barton, Adam Edward; Bartos, Pavol; Basalaev, Artem; Bassalat, Ahmed; Basye, Austin; Bates, Richard; Batista, Santiago Juan; Batley, Richard; Battaglia, Marco; Bauce, Matteo; Bauer, Florian; Bawa, Harinder Singh; Beacham, James Baker; Beattie, Michael David; Beau, Tristan; Beauchemin, Pierre-Hugues; Beccherle, Roberto; Bechtle, Philip; Beck, Hans Peter; Becker, Kathrin; Becker, Maurice; Becker, Sebastian; Beckingham, Matthew; Becot, Cyril; Beddall, Andrew; Beddall, Ayda; Bednyakov, Vadim; Bee, Christopher; Beemster, Lars; Beermann, Thomas; Begel, Michael; Behr, Janna Katharina; Belanger-Champagne, Camille; Bell, William; Bella, Gideon; Bellagamba, Lorenzo; Bellerive, Alain; Bellomo, Massimiliano; Belotskiy, Konstantin; Beltramello, Olga; Benary, Odette; Benchekroun, Driss; Bender, Michael; Bendtz, Katarina; Benekos, Nektarios; Benhammou, Yan; Benhar Noccioli, Eleonora; Benitez Garcia, Jorge-Armando; Benjamin, Douglas; Bensinger, James; Bentvelsen, Stan; Beresford, Lydia; Beretta, Matteo; Berge, David; Bergeaas Kuutmann, Elin; Berger, Nicolas; Berghaus, Frank; Beringer, Jürg; Bernard, Clare; Bernard, Nathan Rogers; Bernius, Catrin; Bernlochner, Florian Urs; Berry, Tracey; Berta, Peter; Bertella, Claudia; Bertoli, Gabriele; Bertolucci, Federico; Bertsche, Carolyn; Bertsche, David; Besana, Maria Ilaria; Besjes, Geert-Jan; Bessidskaia Bylund, Olga; Bessner, Martin Florian; Besson, Nathalie; Betancourt, Christopher; Bethke, Siegfried; Bevan, Adrian John; Bhimji, Wahid; Bianchi, Riccardo-Maria; Bianchini, Louis; Bianco, Michele; Biebel, Otmar; Biedermann, Dustin; Bieniek, Stephen Paul; Biglietti, Michela; Bilbao De Mendizabal, Javier; Bilokon, Halina; Bindi, Marcello; Binet, Sebastien

    2015-01-01

    An observation of the $\\Lambda_b^0 \\rightarrow \\psi(2S) \\Lambda^0$ decay and a comparison of its branching fraction with that of the $\\Lambda_b^0 \\rightarrow J/\\psi \\Lambda^0$ decay has been made with the ATLAS detector in proton--proton collisions at $\\sqrt{s}=8\\,$TeV at the LHC using an integrated luminosity of $20.6\\,$fb$^{-1}$. The $J/\\psi$ and $\\psi(2S)$ mesons are reconstructed in their decays to a muon pair, while the $\\Lambda^0\\rightarrow p\\pi^-$ decay is exploited for the $\\Lambda^0$ baryon reconstruction. The $\\Lambda_b^0$ baryons are reconstructed with transverse momentum $p_{\\rm T}>10\\,$GeV and pseudorapidity $|\\eta|<2.1$. The measured branching ratio of the $\\Lambda_b^0 \\rightarrow \\psi(2S) \\Lambda^0$ and $\\Lambda_b^0 \\rightarrow J/\\psi \\Lambda^0$ decays is $\\Gamma(\\Lambda_b^0 \\rightarrow \\psi(2S)\\Lambda^0)/\\Gamma(\\Lambda_b^0 \\rightarrow J/\\psi\\Lambda^0) = 0.501\\pm 0.033 ({\\rm stat})\\pm 0.019({\\rm syst})$, lower than the expectation from the covariant quark model.

  4. Possibility of \\Lambda\\Lambda pairing and its dependence on background density in relativistic Hartree-Bogoliubov model

    CERN Document Server

    Tanigawa, T; Chiba, S; Tanigawa, Tomonori; Matsuzaki, Masayuki; Chiba, Satoshi

    2003-01-01

    We calculate a \\Lambda\\Lambda pairing gap in binary mixed matter of nucleons and \\Lambda hyperons within the relativistic Hartree-Bogoliubov model since a recent experiment suggests a weaker \\Lambda\\Lambda attraction than before, which has a significant impact on properties of neutron stars in various aspects. Lambda hyperons to be paired up are immersed in background nucleons in normal state. A phenomenological \\Lambda\\Lambda interaction, which is derived relativistically from the Lagrangian of the system, is adopted to the gap equation. It is found that at background density \\rho_{N}=2.5\\rho_{0} the \\Lambda\\Lambda pairing gap is very small, and that denser background makes it rapidly suppressed. This result suggests a mechanism, specific to mixed matter dealt with relativistic models, of its dependence on the nucleon density.

  5. Search for $\\bar{B}^0\\to\\Lambda_c^+\\Lambda_c^-$ decay at Belle

    CERN Document Server

    Abe, K; Aihara, H; Arinstein, K; Aso, T; Aulchenko, V; Aushev, T; Aziz, T; Bahinipati, S; Bakich, A M; Balagura, V; Ban, Y; Banerjee, S; Barberio, E; Bay, A; Bedny, I; Belous, K S; Bhardwaj, V; Bitenc, U; Blyth, S; Bondar, A; Bozek, A; Bracko, M; Brodzicka, J; Browder, T E; Chang, M C; Chang, P; Chao, Y; Chen, A; Chen, K F; Chen, W T; Cheon, B G; Chiang, C C; Chistov, R; Cho, I S; Choi, S K; Choi, Y; Choi, Y K; Cole, S; Dalseno, J; Danilov, M; Das, A; Dash, M; Dragic, J; Drutskoy, A; Eidelman, S; Epifanov, D; Fratina, S; Fujii, H; Fujikawa, M; Gabyshev, N; Garmash, A; Go, A; Gokhroo, G; Goldenzweig, P; Golob, B; Grosse-Perdekamp, M; Guler, H; Ha, H; Haba, J; Hara, K; Hara, T; Hasegawa, Y; Hastings, N C; Hayasaka, K; Hayashii, H; Hazumi, M; Heffernan, D; Higuchi, T; Hinz, L; Hoedlmoser, H; Hokuue, T; Horii, Y; Hoshi, Y; Hoshina, K; Hou, S; Hou, W S; Hsiung, Y B; Hyun, H J; Igarashi, Y; Iijima, T; Ikado, K; Inami, K; Ishikawa, A; Ishino, H; Itoh, R; Iwabuchi, M; Iwasaki, M; Iwasaki, Y; Jacoby, C; Joshi, N J; Kaga, M; Kah, D H; Kaji, H; Kajiwara, S; Kakuno, H; Kang, J H; Kapusta, P; Kataoka, S U; Katayama, N; Kawai, H; Kawasaki, T; Kibayashi, A; Kichimi, H; Kim, H J; Kim, H O; Kim, J H; Kim, S K; Kim, Y J; Kinoshita, K; Korpar, S; Kozakai, Y; Krizan, P; Krokovny, P; Kumar, R; Kurihara, E; Kusaka, A; Kuzmin, A; Kwon, Y J; Lange, J S; Leder, G; Lee, J; Lee, J S; Lee, M J; Lee, S E; Lesiak, T; Li, J; Limosani, A; Lin, S W; Liu, Y; Liventsev, D; MacNaughton, J; Majumder, G; Mandl, F; Marlow, D; Matsumura, T; Matyja, A; McOnie, S; Medvedeva, T; Mikami, Y; Mitaroff, W A; Miyabayashi, K; Miyake, H; Miyata, H; Miyazaki, Y; Mizuk, R; Moloney, G R; Mori, T; Müller, J; Murakami, A; Nagamine, T; Nagasaka, Y; Nakahama, Y; Nakamura, I; Nakano, E; Nakao, M; Nakayama, H; Nakazawa, H; Natkaniec, Z; Neichi, K; Nishida, S; Nishimura, K; Nishio, Y; Nishizawa, I; Nitoh, O; Noguchi, S; Nozaki, T; Ogawa, A; Ogawa, S; Ohshima, T; Okuno, S; Olsen, S L; Ono, S; Ostrowicz, W; Ozaki, H; Pakhlov, P; Pakhlova, G; Palka, H; Park, C W; Park, H; Park, K S; Parslow, N; Peak, L S; Pernicka, M; Pestotnik, R; Peters, M; Piilonen, L E; Poluektov, A; Rorie, J; Rózanska, M; Sahoo, H; Sakai, Y; Sakamoto, H; Sakaue, H; Sarangi, T R; Satoyama, N; Sayeed, K; Schietinger, T; Schneider, O; Schonmeier, P; Schümann, J; Schwanda, C; Schwartz, A J; Seidl, R; Sekiya, A; Senyo, K; Sevior, M E; Shang, L; Shapkin, M; Shen, C P; Shibuya, H; Shinomiya, S; Shiu, J G; Shwartz, B; Singh, J B; Sokolov, A; Solovieva, E; Somov, A; Stanic, S; Staric, M; Stypula, J; Sugiyama, A; Sumisawa, K; Sumiyoshi, T; Suzuki, S; Suzuki, S Y; Tajima, O; Takasaki, F; Tamai, K; Tamura, N; Tanaka, M; Taniguchi, N; Taylor, G N; Teramoto, Y; Tikhomirov, I; Trabelsi, K; Tse, Y F; Tsuboyama, T; Uchida, K; Uchida, Y; Uehara, S; Ueno, K; Uglov, T; Unno, Y; Uno, S; Urquijo, P; Ushiroda, Y; Usov, Yu; Varner, G; Varvell, K E; Vervink, K; Villa, S; Vinokurova, A; Wang, C C; Wang, C H; Wang, J; Wang, M Z; Wang, P; Wang, X L; Watanabe, M; Watanabe, Y; Wedd, R; Wicht, J; Widhalm, L; Wiechczynski, J; Won, E; Yabsley, B D; Yamaguchi, A; Yamamoto, H; Yamaoka, M; Yamashita, Y; Yamauchi, M; Yuan, C Z; Yusa, Y; Zhang, C C; Zhang, L M; Zhang, Z P; Zhilich, V; Zhulanov, V; Zupanc, A; Zwahlen, N

    2007-01-01

    We search for the doubly charmed baryonic decay $\\bar{B}^0\\to\\Lambda_c^+\\Lambda_c^-$, in a data sample of 479 fb^{-1} accumulated at the $\\Upsilon(4S)$ resonance with the Belle detector at the KEKB asymmetric e^+e^- collider. We find no significant signal and set an upper limit of ${\\cal B}(\\bar{B}^0\\to\\Lambda_c^+\\Lambda_c^-)<6.2\\times10^{-5}$ at 90% confidence level. The result is significantly below a naive extrapolation from ${\\cal B}(B^-\\to\\Xi_c^0\\Lambda_c^)$ assuming a simple Cabibbo-suppression factor of $|V_{cd}/V_{cs}|^2$. The small branching fraction could be attributed to a suppression of the branching fraction due to the large Q value; a general trend observed in various charmed baryonic two-body B decays.

  6. Measurements of $\\Lambda^+_c$ Branching Fractions of Cabibbo-Suppressed Decay Modes involving $\\Lambda$ and $\\Sigma^{0}$

    CERN Document Server

    Aubert, B; Abrams, G S; Adye, T; Ahmed, M; Ahmed, S; Alam, M S; Albert, J; Aleksan, Roy; Allen, M T; Allison, J; Allmendinger, T; Altenburg, D; Andreassen, R; Andreotti, M; Angelini, C; Anulli, F; Arnaud, N; Aston, D; Azzolini, V; Baak, M; Back, J J; Baldini-Ferroli, R; Band, H R; Banerjee, S; Barate, R; Bard, D J; Barlow, N R; Barlow, R J; Barrett, M; Bartoldus, R; Batignani, G; Battaglia, M; Bauer, J M; Beck, T W; Behera, P K; Bellini, F; Benayoun, M; Benelli, G; Berger, N; Bernard, D; Berryhill, J W; Best, D; Bettarini, S; Bettoni, D; Bevan, A J; Bhimji, W; Bhuyan, B; Bianchi, F; Biasini, M; Biesiada, J; Blanc, F; Blaylock, G; Blinov, A E; Blinov, V E; Bloom, P C; Blount, N L; Bomben, M; Bondioli, M; Bonneaud, G R; Bosisio, L; Boutigny, D; Bowerman, D A; Boyarski, A M; Boyd, J T; Bozzi, C; Brandenburg, G; Brandt, T; Brau, J E; Breon, A B; Brose, J; Brown, C L; Brown, C M; Brown, D N; Bruinsma, M; Brunet, S; Bucci, F; Buchanan, C; Buchmüller, O L; Bugg, W; Bukin, A D; Bula, R; Bulten, H; Burchat, P R; Burke, J P; Button-Shafer, J; Buzzo, A; Bóna, M; Cahn, R N; Calabrese, R; Calcaterra, A; Calderini, G; Campagnari, C; Capra, R; Carpinelli, M; Cartaro, C; Cavallo, N; Cavoto, G; Cenci, R; Chai, X; Chaisanguanthum, K S; Chao, M; Charles, E; Charles, M J; Chauveau, J; Chavez, C A; Chen, A; Chen, C; Chen, E; Chen, J C; Chen, S; Chen, X; Cheng, B; Cheng, C H; Chia, Y M; Cibinetto, G; Clark, P J; Claus, R; Cochran, J; Coleman, J P; Contri, R; Convery, M R; Cossutti, F; Cottingham, W N; Couderc, F; Covarelli, R; Cowan, G; Cowan, R; Crawley, H B; Cremaldi, L; Cristinziani, M; Cunha, A; Curry, S; Côté, D; D'Orazio, A; Dahmes, B; Dallapiccola, C; Danielson, N; Dasu, S; Datta, M; Dauncey, P D; David, P; Davier, M; Davis, C L; Day, C T; De Groot, N; De Nardo, Gallieno; De Sangro, R; Del Buono, L; Del Re, D; Della Ricca, G; Di Lodovico, F; Di Marco, E; Dickopp, M; Dingfelder, J C; Dittongo, S; Dong, D; Dong, L; Dorfan, J; Druzhinin, V P; Dubitzky, R S; Dubois-Felsmann, G P; Dujmic, D; Dunwoodie, W M; Dvoretskii, A; Eckhart, E A; Eckmann, R; Edgar, C L; Edwards, A J; Egede, U; Eichenbaum, A M; Eigen, G; Eisner, A M; Elmer, P; Emery, S; Ernst, J A; Eschenburg, V; Eschrich, I; Eyges, V; Fabozzi, F; Faccini, R; Fan, S; Feltresi, E; Ferrarotto, F; Ferroni, F; Field, R C; Finocchiaro, G; Flacco, C J; Flack, R L; Flächer, H U; Flood, K T; Ford, K E; Ford, W T; Forster, I J; Forti, F; Fortin, D; Foulkes, S D; Franek, B; Frey, R; Fritsch, M; Fry, J R; Fulsom, B G; Gabathuler, E; Gaidot, A; Gaillard, J R; Galeazzi, F; Gallo, F; Gamba, D; Gamet, R; Gan, K K; Ganzhur, S F; Gary, J W; Gaspero, M; Gatto, C; George, K A; Gill, M S; Giorgi, M A; Giroux, X; Gladney, L; Glanzman, T; Godang, R; Goetzen, K; Golubev, V B; Gopal, G P; Gowdy, S J; Gradl, W; Graham, M T; Grancagnolo, S; Graugès-Pous, E; Graziani, G; Green, M G; Grenier, P; Gritsan, A V; Grosdidier, G; Groysman, Y; Guo, Q H; Hadavand, H K; Hadig, T; Haire, M; Halyo, V; Hamano, K; Hamel de Monchenault, G; Hamon, O; Harrison, P F; Harrison, T J; Hart, A J; Hartfiel, B L; Hast, C; Hauke, A; Hawkes, C M; Hearty, C; Held, T; Hertzbach, S S; Heusch, C A; Hill, E J; Hirschauer, J F; Hitlin, D G; Hodgkinson, M C; Hollar, J J; Hong, T M; Honscheid, K; Hopkins, D A; Hrynóva, T; Hufnagel, D; Hulsbergen, W D; Hutchcroft, D E; Höcker, A; Igonkina, O; Innes, W R; Izen, J M; Jackson, P D; Jackson, P S; Jacobsen, R G; Jawahery, A; Jessop, C P; John, M J J; Johnson, J R; Judd, D; Kadel, R W; Kadyk, J; Kagan, H; Karyotakis, Yu; Kass, R; Kelly, M P; Kelsey, M H; Kerth, L T; Khan, A; Kim, H; Kim, P; Kirkby, D; Kitayama, I; Klose, V; Knecht, N S; Koch, H; Kocian, M L; Koeneke, K; Kofler, R; Kolomensky, Yu G; Kovalskyi, D; Kowalewski, R V; Kozanecki, Witold; Kravchenko, E A; Kreisel, A; Krishnamurthy, M; Kroeger, R; Kroseberg, J; Kukartsev, G; Kutter, P E; Kyberd, P; La Vaissière, C de; Lacker, H M; Lae, C K; Lafferty, G D; Lanceri, L; Lange, D J; Langenegger, U; Lankford, A J; Latham, T E; Latour, E; Lau, Y P; Lazzaro, A; Le Diberder, F R; Lees, J P; Legendre, M; Leith, D W G S; Lepeltier, V; Leruste, P; Lewandowski, B; Li Gioi, L; Li, H; Li, X; Libby, J; Lista, L; Liu, R; Lo Vetere, M; LoSecco, J M; Lockman, W S; Lombardo, V; London, G W; Long, O; Lou, X C; Lu, M; Luitz, S; Lund, P; Luppi, E; Lusiani, A; Lutz, A M; Lynch, G; Lynch, H L; Lü, C; Lüth, V; MacFarlane, D B; Macri, M M; Mader, W F; Majewski, S A; Malcles, J; Mallik, U; Mancinelli, G; Mandelkern, M A; Marchiori, G; Margoni, M; Marks, J; Marsiske, H; Martínez-Vidal, F; Mattison, T S; Mayer, B; Mazur, M A; Mazzoni, M A; McKenna, J A; McMahon, T R; Meadows, B T; Mellado, B; Menges, W; Messner, R; Meyer, W T; Mihályi, A; Minamora, J S; Mir, L M; Mohanty, G B; Mohapatra, A K; Mommsen, R K; Monge, M R; Monorchio, D; Moore, T B; Morandin, M; Morgan, S E; Morganti, M; Morganti, S; Morii, M; Muheim, F; Müller, D R; Naisbit, M T; Narsky, I; Nash, J A; Nauenberg, U; Neal, H; Negrini, M; Neri, N; Nesom, G; Nicholson, H; Nikolich, M B; Nogowski, R; Nugent, I M; O'Grady, C P; Ocariz, J; Oddone, P J; Ofte, I; Olaiya, E O; Olivas, A; Olsen, J; Onuchin, A P; Orimoto, T J; Otto, S; Oyanguren, A; Ozcan, V E; Paar, H P; Pacetti, S; Palano, A; Palombo, F; Pan, Y; Panduro-Vazquez, W; Panetta, J; Panvini, R S; Paoloni, E; Paolucci, P; Pappagallo, M; Parry, R J; Passaggio, S; Patel, P M; Patrignani, C; Patteri, P; Payne, D J; Pelizaeus, M; Perazzo, A; Perl, M; Peruzzi, I M; Peters, K; Petersen, B A; Petersen, T C; Petzold, A; Piatenko, T; Piccolo, D; Piccolo, M; Piemontese, L; Pierini, M; Pioppi, M; Piredda, G; Plaszczynski, S; Playfer, S; Poireau, V; Polci, F; Pompili, A; Porter, F C; Posocco, M; Potter, C T; Prell, S; Prepost, R; Pripstein, M; Pulliam, T; Purohit, M V; Qi, N D; Rahatlou, S; Rahimi, A M; Rahmat, R; Rama, M; Ratcliff, B N; Raven, G; Reidy, J; Ricciardi, S; Richman, J D; Ritchie, J L; Rizzo, G; Roat, C; Roberts, D A; Robertson, S H; Robutti, E; Rodier, S; Roe, N A; Ronan, M T; Roney, J M; Rong, G; Roodman, A; Roos, L; Rosenberg, E I; Rotondo, M; Roudeau, P; Rubin, A E; Ruddick, W O; Ryd, A; Röthel, W; Sacco, R; Saeed, M A; Safai-Tehrani, F; Saleem, M; Salnikov, A A; Salvatore, F; Samuel, A; Sanders, D A; Santroni, A; Saremi, S; Satpathy, A; Schalk, T; Schenk, S; Schindler, R H; Schofield, K C; Schott, G; Schrenk, S; Schröder, T; Schröder, H; Schubert, J; Schubert, K R; Schumm, B A; Schune, M H; Schwiening, J; Schwierz, R; Schwitters, R F; Sciacca, C; Sciolla, G; Seiden, A; Sekula, S J; Serednyakov, S I; Sharma, V; Shen, B C; Simi, G; Simonetto, F; Sinev, N B; Skovpen, Yu I; Smith, A J S; Smith, J G; Snoek, H L; Snyder, A; Sobie, R J; Soffer, A; Sokoloff, M D; Solodov, E P; Spaan, B; Spanier, S M; Spitznagel, M; Spradlin, P; Steinke, M; Stelzer, J; Stocchi, A; Stoker, D P; Stroili, R; Strom, D; Strube, J; Stugu, B; Stängle, H; Su, D; Sullivan, M K; Summers, D J; Sundermann, J E; Suzuki, K; Swain, S K; Tan, P; Taras, P; Taylor, F; Telnov, A V; Teodorescu, L; Ter-Antonian, R; Therin, G; Thiebaux, C; Thompson, J M; Tisserand, V; Toki, W H; Torrence, E; Tosi, S; Touramanis, C; Ulmer, K A; Uwer, U; Van Bakel, N; Vasileiadis, G; Vasseur, G; Vavra, J; Verderi, M; Verkerke, W; Viaud, F B; Vitale, L; Voci, C; Voena, C; Wagner, S R; Wagoner, D E; Waldi, R; Walsh, J; Wang, K; Wang, P; Wang, W F; Wappler, F R; Watson, A T; Weaver, M; Weidemann, A W; Weinstein, A J R; Wenzel, W A; Wilden, L; Williams, D C; Williams, J C; Willocq, S Y; Wilson, F F; Wilson, J R; Wilson, M G; Wilson, R J; Winklmeier, F; Wisniewski, W J; Wittgen, M; Wong, Q K; Wormser, G; Wright, D H; Wright, D M; Wu, J; Wu, S L; Xie, Y; Yamamoto, R K; Yarritu, A K; Ye, S; Yi, J I; Yi, K; Young, C C; Yu, Z; Yushkov, A N; Yéche, C; Zain, S B; Zallo, A; Zeng, Q; Zghiche, A; Zhang, J; Zhang, L; Zhao, H W; Zhu, Y S; Ziegler, V; Zito, M; Çuhadar-Dönszelmann, T

    2007-01-01

    We measure the branching ratios of the Cabibbo-suppressed decays $\\Lambda^+_c$ $\\to$ $\\Lambda$ $K^+$ and $\\Lambda^+_c$ $\\to$ $\\Sigma^{0}$ $K^+$ %(measured with improved accuracy). relative to the Cabibbo-favored decay modes $\\Lambda^+_c$ $\\to$ $\\Lambda$ $\\pi^+$ and $\\Lambda^+_c$ $\\to$ $\\Sigma^{0}$ $\\pi^+$ to be $ 0.044 \\pm 0.004 ~(\\textnormal{stat.})~ \\pm ~0.003 \\~(\\textnormal{syst.})$ and $ 0.039~ \\pm ~0.005 ~(\\textnormal{stat.})~ \\pm \\~0.003 ~(\\textnormal{syst.})$, respectively. We set an upper limit on the branching ratio at 90 % confidence level for $\\Lambda^+_c$ $\\to$ $\\Lambda$ $K^+ \\pi^+ \\pi^-$ to be $ 4.1 \\times ~10^{-2}$ relative to $\\Lambda^+_c$ $\\to$ $\\Lambda$ $\\pi^+$ and for $\\Lambda^+_c$ $\\to$ $\\Sigma^{0}$ $K^+ \\pi^+ \\pi^-$ to be $ 2.0 \\times ~10^{-2}$ relative to $\\Lambda^+_c$ $\\to$ $\\Sigma^{0}$ $\\pi^+$. We also measure the branching fraction for the Cabibbo-favored mode $\\Lambda^+_c$ $\\to$ $\\Sigma^{0}$ $\\pi^+$ relative to $\\Lambda^+_c$ $\\to$ $\\Lambda$ $\\pi^+$ to be $0.977~ \\pm ~0.015 ~(\\textnorm...

  7. Inhomogeneity of the $\\Lambda$LTB models

    CERN Document Server

    Sundell, Peter

    2016-01-01

    The Lema\\'itre-Toman-Bondi (LTB) models have reported to suffer from incompatibility with cosmological observations and fine-tuning of the observer's location. Further analysis of these issues indicates that they could be resolved by models that are compatible with the supernova Ia data, but less inhomogeneous than those that have been presented in the literature so far. We study if such models exist by employing the degrees of freedom of the LTB models in a novel manner. We discovered two scenarios which may meet the expectations, but extensive numerical and analytical investigation showed them inviable. We extended our studies to the $\\Lambda$LTB models, which generalizes the LTB models by including a non-zero cosmological constant $\\Lambda$ in Einsteins equations. This adds an additional degree of freedom for the earlier scenarios and introduces a new scenario capable of meeting the expectations. However, extensive numerical and analytical investigation reveals that inclusion of $\\Lambda$ does not enhance ...

  8. Propagating the missing bacteriophages: a large bacteriophage in a new class

    Directory of Open Access Journals (Sweden)

    Hardies Stephen C

    2007-02-01

    Full Text Available Abstract The number of successful propagations/isolations of soil-borne bacteriophages is small in comparison to the number of bacteriophages observed by microscopy (great plaque count anomaly. As one resolution of the great plaque count anomaly, we use propagation in ultra-dilute agarose gels to isolate a Bacillus thuringiensis bacteriophage with a large head (95 nm in diameter, tail (486 × 26 nm, corkscrew-like tail fibers (187 × 10 nm and genome (221 Kb that cannot be detected by the usual procedures of microbiology. This new bacteriophage, called 0305φ8-36 (first number is month/year of isolation; remaining two numbers identify the host and bacteriophage, has a high dependence of plaque size on the concentration of a supporting agarose gel. Bacteriophage 0305φ8-36 does not propagate in the traditional gels used for bacteriophage plaque formation and also does not produce visible lysis of liquid cultures. Bacteriophage 0305φ8-36 aggregates and, during de novo isolation from the environment, is likely to be invisible to procedures of physical detection that use either filtration or centrifugal pelleting to remove bacteria. Bacteriophage 0305φ8-36 is in a new genomic class, based on genes for both structural components and DNA packaging ATPase. Thus, knowledge of environmental virus diversity is expanded with prospect of greater future expansion.

  9. Immunocompatibility of Bacteriophages as Nanomedicines

    Directory of Open Access Journals (Sweden)

    Tranum Kaur

    2012-01-01

    Full Text Available Bacteriophage-based medical research provides the opportunity to develop targeted nanomedicines with heightened efficiency and safety profiles. Filamentous phages also can and have been formulated as targeted drug-delivery nanomedicines, and phage may also serve as promising alternatives/complements to antibiotics. Over the past decade the use of phage for both the prophylaxis and the treatment of bacterial infection, has gained special significance in view of a dramatic rise in the prevalence of antibiotic resistance bacterial strains. Two potential medical applications of phages are the treatment of bacterial infections and their use as immunizing agents in diagnosis and monitoring patients with immunodeficiencies. Recently, phages have been employed as gene-delivery vectors (phage nanomedicine, for nearly half a century as tools in genetic research, for about two decades as tools for the discovery of specific target-binding proteins and peptides, and for almost a decade as tools for vaccine development. As phage applications to human therapeutic development grow at an exponential rate, it will become essential to evaluate host immune responses to initial and repetitive challenges by therapeutic phage in order to develop phage therapies that offer suitable utility. This paper examines and discusses phage nanomedicine applications and the immunomodulatory effects of bacteriophage exposure and treatment modalities.

  10. Novel DNA packaging recognition in the unusual bacteriophage N15

    International Nuclear Information System (INIS)

    Phage lambda's cosB packaging recognition site is tripartite, consisting of 3 TerS binding sites, called R sequences. TerS binding to the critical R3 site positions the TerL endonuclease for nicking cosN to generate cohesive ends. The N15 cos (cosN15) is closely related to cosλ, but whereas the cosBN15 subsite has R3, it lacks the R2 and R1 sites and the IHF binding site of cosBλ. A bioinformatic study of N15-like phages indicates that cosBN15 also has an accessory, remote rR2 site, which is proposed to increase packaging efficiency, like R2 and R1 of lambda. N15 plus five prophages all have the rR2 sequence, which is located in the TerS-encoding 1 gene, approximately 200 bp distal to R3. An additional set of four highly related prophages, exemplified by Monarch, has R3 sequence, but also has R2 and R1 sequences characteristic of cosB–λ. The DNA binding domain of TerS-N15 is a dimer. - Highlights: • There are two classes of DNA packaging signals in N15-related phages. • Phage N15's TerS binding site: a critical site and a possible remote accessory site. • Viral DNA recognition signals by the λ-like bacteriophages: the odd case of N15

  11. Novel DNA packaging recognition in the unusual bacteriophage N15

    Energy Technology Data Exchange (ETDEWEB)

    Feiss, Michael [Department of Microbiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242 (United States); Geyer, Henriette, E-mail: henriettegeyer@gmail.com [Division of Viral Infections, Robert Koch Institute, Berlin (Germany); Division of Viral Infections, Robert Koch Institute, Berlin (Germany); Klingberg, Franco, E-mail: franco.klingberg@thermofisher.com [Flow Cytometry, Imaging & Microscopy, Thermo Fisher Scientific, Frankfurter Strasse 129B 64293 Darmstadt (Germany); Flow Cytometry, Imaging & Microscopy, Thermo Fisher Scientific, Frankfurter Strasse 129B 64293 Darmstadt (Germany); Moreno, Norma, E-mail: nmoreno@islander.tamucc.edu [Texas A& M University – Corpus Christi, 6300 Ocean Drive, Corpus Christi, TX 78412, United States. (United States); Texas A& M University – Corpus Christi, 6300 Ocean Drive, Corpus Christi, TX 78412, United States. (United States); Forystek, Amanda, E-mail: eamanda-forystek@uiowa.edu [Flow Cytometry, Imaging & Microscopy, Thermo Fisher Scientific, Frankfurter Strasse 129B 64293 Darmstadt (Germany); Room # 2911 JPP, Dept. of Psychiatry, The University of Iowa, 200 Hawkins Drive, Iowa City, Iowa, 52242 (United States); Maluf, Nasib Karl, E-mail: fKarl.Maluf@ap-lab.com [Flow Cytometry, Imaging & Microscopy, Thermo Fisher Scientific, Frankfurter Strasse 129B 64293 Darmstadt (Germany); Alliance Protein Laboratories, Inc. 6042 Cornerstone Court West, Suite ASan Diego, CA 92121, USA. (United States); Sippy, Jean [Department of Microbiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242 (United States)

    2015-08-15

    Phage lambda's cosB packaging recognition site is tripartite, consisting of 3 TerS binding sites, called R sequences. TerS binding to the critical R3 site positions the TerL endonuclease for nicking cosN to generate cohesive ends. The N15 cos (cos{sup N15}) is closely related to cos{sup λ}, but whereas the cosB{sup N15} subsite has R3, it lacks the R2 and R1 sites and the IHF binding site of cosB{sup λ}. A bioinformatic study of N15-like phages indicates that cosB{sup N15} also has an accessory, remote rR2 site, which is proposed to increase packaging efficiency, like R2 and R1 of lambda. N15 plus five prophages all have the rR2 sequence, which is located in the TerS-encoding 1 gene, approximately 200 bp distal to R3. An additional set of four highly related prophages, exemplified by Monarch, has R3 sequence, but also has R2 and R1 sequences characteristic of cosB–λ. The DNA binding domain of TerS-N15 is a dimer. - Highlights: • There are two classes of DNA packaging signals in N15-related phages. • Phage N15's TerS binding site: a critical site and a possible remote accessory site. • Viral DNA recognition signals by the λ-like bacteriophages: the odd case of N15.

  12. Observation of excess $\\lambda\\overline{\\lambda}$ production in two-photon processes at TRISTAN

    CERN Document Server

    Enomoto, R; Abe, T; Adachi, I; Adachi, K; Aoki, M; Awa, S; Emi, K; Fujii, H; Fujii, K; Fujii, T; Fujimoto, J; Fujita, K; Fujiwara, N; Hayashii, H; Howell, B; Iida, N; Itoh, R; Inoue, Y; Iwasaki, H; Iwasaki, M; Kaneyuki, K; Kajikawa, R; Kato, S; Kawabata, S; Kichimi, H; Kobayashi, M; Koltick, D S; Levine, I; Minami, S; Miyabayashi, K; Miyamoto, A; Muramatsu, K; Nagai, K; Nakabayashi, K; Nakano, E; Nitoh, O; Noguchi, S; Ochi, A; Ochiai, F; Ohishi, N; Ohnishi, Y; Ohshima, Y; Okuno, H; Okusawa, T; Shinohara, T; Sugiyama, A; Suzuki, S; Takahashi, K; Takahashi, T; Tanimori, T; Tauchi, T; Teramoto, Y; Toomi, N; Tsukamoto, T; Tsumura, O; Uno, S; Watanabe, T; Watanabe, Y; Yamaguchi, A; Yamamoto, A; Yamauchi, M; Enomoto, R

    1995-01-01

    We have carried out inclusive measurements of \\Lambda(\\overline{\\Lamb da}) production in two-photon processes at TRISTAN. The mean \\sqrt{s} was 58 GeV and the integrated luminosity was 265 pb^{-1}. Inclusive \\Lambda (\\overline{\\Lambda}) samples were obtained under such conditions as no-electron, anti-electron, and remnant-jet tags. The data were compared with theoretical calculations. The measured cross sections are two-times larger than the leading-order theoretical predictions, suggesting the necessity of next-to-leading-order Monte-Carlo generator.

  13. Bacteriophages of Leuconostoc, Oenococcus, and Weissella

    DEFF Research Database (Denmark)

    Kot, Witold; Neve, Horst; Heller, Knut J;

    2014-01-01

    can be classified as either Ln. mesenteroides or Ln. pseudomesenteroides. They are important flavor producers in dairy fermentations and they initiate nearly all vegetable fermentations. Therefore, bacteriophages attacking Leuconostoc strains may negatively influence the production process....... Bacteriophages attacking Leuconostoc strains were first reported in 1946. Since then, the majority of described Leuconostoc phages was isolated from either dairy products or fermented vegetable products. Both lytic and temperate phages of Leuconostoc were reported. Most of Leuconostoc phages examined using...

  14. Lambda-Lifting in Quadratic Time

    DEFF Research Database (Denmark)

    Danvy, Olivier; Schultz, Ulrik Pagh

    2002-01-01

    local function in the source program. Each equation carries extra parameters to account for the free variables of the corresponding local function and of all its callees. It is the search for these extra parameters that yields the cubic factor in the traditional formulation of lambda-lifting, which...

  15. Characterization and purification of bacteriophages using chromatofocusing.

    Science.gov (United States)

    Brorson, Kurt; Shen, Hong; Lute, Scott; Pérez, Jessica Soto; Frey, Douglas D

    2008-10-17

    The technique of chromatofocusing was applied to the characterization and purification of three bacteriophages that are routinely used for testing virus filters: phiX174, PR772, and PP7. Chemically well-defined eluent buffers were used, instead of the more commonly used chromatofocusing polyampholyte buffers. Chromatographic column packings were selected to minimize band broadening by confining bacteriophage adsorption solely to the exterior particle surface. Under the conditions used it was determined that bacteriophages could be made to focus into narrow bands in a retained pH gradient with recoveries of live phage that ranged from 15 to nearly 100% as determined by a plaque-forming assay. Retention times and apparent isoelectric point data were obtained for samples consisting either of purified bacteriophage, or samples consisting of crude preparations of bacteriophages containing host cell impurities. Isoelectric point estimates were obtained using modified, previously described models. The results obtained suggest that chromatofocusing is a simple and rapid method for obtaining approximate isoelectric points for bacteriophages and probably other types of viruses. It is also likely a useful method for purifying these materials.

  16. Faddeev calculation of 6 He Lambda Lambda using SU_6 quark-model baryon-baryon interactions

    CERN Document Server

    Fujiwara, Y; Miyagawa, K; Suzuki, Y; Sparenberg, J M

    2004-01-01

    Quark-model hyperon-nucleon and hyperon-hyperon interactions by the Kyoto-Niigata group are applied to the two-Lambda plus alpha system in a new three-cluster Faddeev formalism using two-cluster resonating-group method kernels. The model fss2 gives a reasonable two-Lambda separation energy Delta B_{Lambda Lambda}=1.41 MeV, which is consistent with the recent empirical value, Delta B^{exp}_{Lambda Lambda}=1.01 +/- 0.20 MeV, deduced from the Nagara event. Some important effects that are not taken into account in the present calculation are discussed.

  17. Observations of $\\Lambda_b^0 \\to \\Lambda K^+\\pi^-$ and $\\Lambda_b^0 \\to \\Lambda K^+K^-$ decays and searches for other $\\Lambda_b^0$ and $\\Xi_b^0$ decays to $\\Lambda h^+h^{\\prime -}$ final states

    CERN Document Server

    AUTHOR|(CDS)2075808; Adeva, Bernardo; Adinolfi, Marco; Ajaltouni, Ziad; Akar, Simon; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio Augusto; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; An, Liupan; Anderlini, Lucio; Andreassi, Guido; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Aquines Gutierrez, Osvaldo; Archilli, Flavio; d'Argent, Philippe; Artamonov, Alexander; Artuso, Marina; Aslanides, Elie; Auriemma, Giulio; Baalouch, Marouen; Bachmann, Sebastian; Back, John; Badalov, Alexey; Baesso, Clarissa; Baker, Sophie; Baldini, Wander; Barlow, Roger; Barschel, Colin; Barsuk, Sergey; Barter, William; Batozskaya, Varvara; Battista, Vincenzo; Bay, Aurelio; Beaucourt, Leo; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Bel, Lennaert; Bellee, Violaine; Belloli, Nicoletta; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Benton, Jack; Berezhnoy, Alexander; Bernet, Roland; Bertolin, Alessandro; Betti, Federico; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bifani, Simone; Billoir, Pierre; Bird, Thomas; Birnkraut, Alex; Bizzeti, Andrea; Blake, Thomas; Blanc, Frédéric; Blouw, Johan; Blusk, Steven; Bocci, Valerio; Bondar, Alexander; Bondar, Nikolay; Bonivento, Walter; Borgheresi, Alessio; Borghi, Silvia; Borisyak, Maxim; Borsato, Martino; Boubdir, Meriem; Bowcock, Themistocles; Bowen, Espen Eie; Bozzi, Concezio; Braun, Svende; Britsch, Markward; Britton, Thomas; Brodzicka, Jolanta; Buchanan, Emma; Burr, Christopher; Bursche, Albert; Buytaert, Jan; Cadeddu, Sandro; Calabrese, Roberto; Calvi, Marta; Calvo Gomez, Miriam; Campana, Pierluigi; Campora Perez, Daniel; Capriotti, Lorenzo; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carniti, Paolo; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casse, Gianluigi; Cassina, Lorenzo; Castillo Garcia, Lucia; Cattaneo, Marco; Cauet, Christophe; Cavallero, Giovanni; Cenci, Riccardo; Charles, Matthew; Charpentier, Philippe; Chatzikonstantinidis, Georgios; Chefdeville, Maximilien; Chen, Shanzhen; Cheung, Shu-Faye; Chrzaszcz, Marcin; Cid Vidal, Xabier; Ciezarek, Gregory; Clarke, Peter; Clemencic, Marco; Cliff, Harry; Closier, Joel; Coco, Victor; Cogan, Julien; Cogneras, Eric; Cogoni, Violetta; Cojocariu, Lucian; Collazuol, Gianmaria; Collins, Paula; Comerma-Montells, Albert; Contu, Andrea; Cook, Andrew; Coombes, Matthew; Coquereau, Samuel; Corti, Gloria; Corvo, Marco; Couturier, Benjamin; Cowan, Greig; Craik, Daniel Charles; Crocombe, Andrew; Cruz Torres, Melissa Maria; Cunliffe, Samuel; Currie, Robert; D'Ambrosio, Carmelo; Dall'Occo, Elena; Dalseno, Jeremy; David, Pieter; Davis, Adam; De Aguiar Francisco, Oscar; De Bruyn, Kristof; De Capua, Stefano; De Cian, Michel; De Miranda, Jussara; De Paula, Leandro; De Simone, Patrizia; Dean, Cameron Thomas; Decamp, Daniel; Deckenhoff, Mirko; Del Buono, Luigi; Déléage, Nicolas; Demmer, Moritz; Derkach, Denis; Deschamps, Olivier; Dettori, Francesco; Dey, Biplab; Di Canto, Angelo; Di Ruscio, Francesco; Dijkstra, Hans; Dordei, Francesca; Dorigo, Mirco; Dosil Suárez, Alvaro; Dovbnya, Anatoliy; Dreimanis, Karlis; Dufour, Laurent; Dujany, Giulio; Dungs, Kevin; Durante, Paolo; Dzhelyadin, Rustem; Dziurda, Agnieszka; Dzyuba, Alexey; Easo, Sajan; Egede, Ulrik; Egorychev, Victor; Eidelman, Semen; Eisenhardt, Stephan; Eitschberger, Ulrich; Ekelhof, Robert; Eklund, Lars; El Rifai, Ibrahim; Elsasser, Christian; Ely, Scott; Esen, Sevda; Evans, Hannah Mary; Evans, Timothy; Falabella, Antonio; Färber, Christian; Farley, Nathanael; Farry, Stephen; Fay, Robert; Fazzini, Davide; Ferguson, Dianne; Fernandez Albor, Victor; Ferrari, Fabio; Ferreira Rodrigues, Fernando; Ferro-Luzzi, Massimiliano; Filippov, Sergey; Fiore, Marco; Fiorini, Massimiliano; Firlej, Miroslaw; Fitzpatrick, Conor; Fiutowski, Tomasz; Fleuret, Frederic; Fohl, Klaus; Fontana, Marianna; Fontanelli, Flavio; Forshaw, Dean Charles; Forty, Roger; Frank, Markus; Frei, Christoph; Frosini, Maddalena; Fu, Jinlin; Furfaro, Emiliano; Gallas Torreira, Abraham; Galli, Domenico; Gallorini, Stefano; Gambetta, Silvia; Gandelman, Miriam; Gandini, Paolo; Gao, Yuanning; García Pardiñas, Julián; Garra Tico, Jordi; Garrido, Lluis; Garsed, Philip John; Gascon, David; Gaspar, Clara; Gavardi, Laura; Gazzoni, Giulio; Gerick, David; Gersabeck, Evelina; Gersabeck, Marco; Gershon, Timothy; Ghez, Philippe; Gianì, Sebastiana; Gibson, Valerie; Girard, Olivier Göran; Giubega, Lavinia-Helena; Gligorov, Vladimir; Göbel, Carla; Golubkov, Dmitry; Golutvin, Andrey; Gomes, Alvaro; Gotti, Claudio; Grabalosa Gándara, Marc; Graciani Diaz, Ricardo; Granado Cardoso, Luis Alberto; Graugés, Eugeni; Graverini, Elena; Graziani, Giacomo; Grecu, Alexandru; Griffith, Peter; Grillo, Lucia; Grünberg, Oliver; Gui, Bin; Gushchin, Evgeny; Guz, Yury; Gys, Thierry; Hadavizadeh, Thomas; Hadjivasiliou, Christos; Haefeli, Guido; Haen, Christophe; Haines, Susan; Hall, Samuel; Hamilton, Brian; Han, Xiaoxue; Hansmann-Menzemer, Stephanie; Harnew, Neville; Harnew, Samuel; Harrison, Jonathan; He, Jibo; Head, Timothy; Heister, Arno; Hennessy, Karol; Henrard, Pierre; Henry, Louis; Hernando Morata, Jose Angel; van Herwijnen, Eric; Heß, Miriam; Hicheur, Adlène; Hill, Donal; Hoballah, Mostafa; Hombach, Christoph; Hongming, Li; Hulsbergen, Wouter; Humair, Thibaud; Hushchyn, Mikhail; Hussain, Nazim; Hutchcroft, David; Idzik, Marek; Ilten, Philip; Jacobsson, Richard; Jaeger, Andreas; Jalocha, Pawel; Jans, Eddy; Jawahery, Abolhassan; John, Malcolm; Johnson, Daniel; Jones, Christopher; Joram, Christian; Jost, Beat; Jurik, Nathan; Kandybei, Sergii; Kanso, Walaa; Karacson, Matthias; Karbach, Moritz; Karodia, Sarah; Kecke, Matthieu; Kelsey, Matthew; Kenyon, Ian; Kenzie, Matthew; Ketel, Tjeerd; Khairullin, Egor; Khanji, Basem; Khurewathanakul, Chitsanu; Kirn, Thomas; Klaver, Suzanne; Klimaszewski, Konrad; Kolpin, Michael; Komarov, Ilya; Koopman, Rose; Koppenburg, Patrick; Kozeiha, Mohamad; Kravchuk, Leonid; Kreplin, Katharina; Kreps, Michal; Krokovny, Pavel; Kruse, Florian; Krzemien, Wojciech; Kucewicz, Wojciech; Kucharczyk, Marcin; Kudryavtsev, Vasily; Kuonen, Axel Kevin; Kurek, Krzysztof; Kvaratskheliya, Tengiz; Lacarrere, Daniel; Lafferty, George; Lai, Adriano; Lambert, Dean; Lanfranchi, Gaia; Langenbruch, Christoph; Langhans, Benedikt; Latham, Thomas; Lazzeroni, Cristina; Le Gac, Renaud; van Leerdam, Jeroen; Lees, Jean-Pierre; Lefèvre, Regis; Leflat, Alexander; Lefrançois, Jacques; Lemos Cid, Edgar; Leroy, Olivier; Lesiak, Tadeusz; Leverington, Blake; Li, Yiming; Likhomanenko, Tatiana; Lindner, Rolf; Linn, Christian; Lionetto, Federica; Liu, Bo; Liu, Xuesong; Loh, David; Longstaff, Iain; Lopes, Jose; Lucchesi, Donatella; Lucio Martinez, Miriam; Luo, Haofei; Lupato, Anna; Luppi, Eleonora; Lupton, Oliver; Lusardi, Nicola; Lusiani, Alberto; Lyu, Xiao-Rui; Machefert, Frederic; Maciuc, Florin; Maev, Oleg; Maguire, Kevin; Malde, Sneha; Malinin, Alexander; Manca, Giulia; Mancinelli, Giampiero; Manning, Peter Michael; Mapelli, Alessandro; Maratas, Jan; Marchand, Jean François; Marconi, Umberto; Marin Benito, Carla; Marino, Pietro; Marks, Jörg; Martellotti, Giuseppe; Martin, Morgan; Martinelli, Maurizio; Martinez Santos, Diego; Martinez Vidal, Fernando; Martins Tostes, Danielle; Massacrier, Laure Marie; Massafferri, André; Matev, Rosen; Mathad, Abhijit; Mathe, Zoltan; Matteuzzi, Clara; Mauri, Andrea; Maurin, Brice; Mazurov, Alexander; McCann, Michael; McCarthy, James; McNab, Andrew; McNulty, Ronan; Meadows, Brian; Meier, Frank; Meissner, Marco; Melnychuk, Dmytro; Merk, Marcel; Merli, Andrea; Michielin, Emanuele; Milanes, Diego Alejandro; Minard, Marie-Noelle; Mitzel, Dominik Stefan; Molina Rodriguez, Josue; Monroy, Igancio Alberto; Monteil, Stephane; Morandin, Mauro; Morawski, Piotr; Mordà, Alessandro; Morello, Michael Joseph; Moron, Jakub; Morris, Adam Benjamin; Mountain, Raymond; Muheim, Franz; Müller, Dominik; Müller, Janine; Müller, Katharina; Müller, Vanessa; Mussini, Manuel; Muster, Bastien; Naik, Paras; Nakada, Tatsuya; Nandakumar, Raja; Nandi, Anita; Nasteva, Irina; Needham, Matthew; Neri, Nicola; Neubert, Sebastian; Neufeld, Niko; Neuner, Max; Nguyen, Anh Duc; Nguyen-Mau, Chung; Niess, Valentin; Nieswand, Simon; Niet, Ramon; Nikitin, Nikolay; Nikodem, Thomas; Novoselov, Alexey; O'Hanlon, Daniel Patrick; Oblakowska-Mucha, Agnieszka; Obraztsov, Vladimir; Ogilvy, Stephen; Okhrimenko, Oleksandr; Oldeman, Rudolf; Onderwater, Gerco; Osorio Rodrigues, Bruno; Otalora Goicochea, Juan Martin; Otto, Adam; Owen, Patrick; Oyanguren, Maria Aranzazu; Palano, Antimo; Palombo, Fernando; Palutan, Matteo; Panman, Jacob; Papanestis, Antonios; Pappagallo, Marco; Pappalardo, Luciano; Pappenheimer, Cheryl; Parker, William; Parkes, Christopher; Passaleva, Giovanni; Patel, Girish; Patel, Mitesh; Patrignani, Claudia; Pearce, Alex; Pellegrino, Antonio; Penso, Gianni; Pepe Altarelli, Monica; Perazzini, Stefano; Perret, Pascal; Pescatore, Luca; Petridis, Konstantinos; Petrolini, Alessandro; Petruzzo, Marco; Picatoste Olloqui, Eduardo; Pietrzyk, Boleslaw; Pikies, Malgorzata; Pinci, Davide; Pistone, Alessandro; Piucci, Alessio; Playfer, Stephen; Plo Casasus, Maximo; Poikela, Tuomas; Polci, Francesco; Poluektov, Anton; Polyakov, Ivan; Polycarpo, Erica; Popov, Alexander; Popov, Dmitry; Popovici, Bogdan; Potterat, Cédric; Price, Eugenia; Price, Joseph David; Prisciandaro, Jessica; Pritchard, Adrian; Prouve, Claire; Pugatch, Valery; Puig Navarro, Albert; Punzi, Giovanni; Qian, Wenbin; Quagliani, Renato; Rachwal, Bartolomiej; Rademacker, Jonas; Rama, Matteo; Ramos Pernas, Miguel; Rangel, Murilo; Raniuk, Iurii; Raven, Gerhard; Redi, Federico; Reichert, Stefanie; dos Reis, Alberto; Renaudin, Victor; Ricciardi, Stefania; Richards, Sophie; Rihl, Mariana; Rinnert, Kurt; Rives Molina, Vincente; Robbe, Patrick; Rodrigues, Ana Barbara; Rodrigues, Eduardo; Rodriguez Lopez, Jairo Alexis; Rodriguez Perez, Pablo; Rogozhnikov, Alexey; Roiser, Stefan; Romanovsky, Vladimir; Romero Vidal, Antonio; Ronayne, John William; Rotondo, Marcello; Ruf, Thomas; Ruiz Valls, Pablo; Saborido Silva, Juan Jose; Sagidova, Naylya; Saitta, Biagio; Salustino Guimaraes, Valdir; Sanchez Mayordomo, Carlos; Sanmartin Sedes, Brais; Santacesaria, Roberta; Santamarina Rios, Cibran; Santimaria, Marco; Santovetti, Emanuele; Sarti, Alessio; Satriano, Celestina; Satta, Alessia; Saunders, Daniel Martin; Savrina, Darya; Schael, Stefan; Schiller, Manuel; Schindler, Heinrich; Schlupp, Maximilian; Schmelling, Michael; Schmelzer, Timon; Schmidt, Burkhard; Schneider, Olivier; Schopper, Andreas; Schubiger, Maxime; Schune, Marie Helene; Schwemmer, Rainer; Sciascia, Barbara; Sciubba, Adalberto; Semennikov, Alexander; Sergi, Antonino; Serra, Nicola; Serrano, Justine; Sestini, Lorenzo; Seyfert, Paul; Shapkin, Mikhail; Shapoval, Illya; Shcheglov, Yury; Shears, Tara; Shekhtman, Lev; Shevchenko, Vladimir; Shires, Alexander; Siddi, Benedetto Gianluca; Silva Coutinho, Rafael; Silva de Oliveira, Luiz Gustavo; Simi, Gabriele; Sirendi, Marek; Skidmore, Nicola; Skwarnicki, Tomasz; Smith, Eluned; Smith, Iwan Thomas; Smith, Jackson; Smith, Mark; Snoek, Hella; Sokoloff, Michael; Soler, Paul; Soomro, Fatima; Souza, Daniel; Souza De Paula, Bruno; Spaan, Bernhard; Spradlin, Patrick; Sridharan, Srikanth; Stagni, Federico; Stahl, Marian; Stahl, Sascha; Stefkova, Slavomira; Steinkamp, Olaf; Stenyakin, Oleg; Stevenson, Scott; Stoica, Sabin; Stone, Sheldon; Storaci, Barbara; Stracka, Simone; Straticiuc, Mihai; Straumann, Ulrich; Sun, Liang; Sutcliffe, William; Swientek, Krzysztof; Swientek, Stefan; Syropoulos, Vasileios; Szczekowski, Marek; Szumlak, Tomasz; T'Jampens, Stephane; Tayduganov, Andrey; Tekampe, Tobias; Tellarini, Giulia; Teubert, Frederic; Thomas, Christopher; Thomas, Eric; van Tilburg, Jeroen; Tisserand, Vincent; Tobin, Mark; Tolk, Siim; Tomassetti, Luca; Tonelli, Diego; Topp-Joergensen, Stig; Tournefier, Edwige; Tourneur, Stephane; Trabelsi, Karim; Traill, Murdo; Tran, Minh Tâm; Tresch, Marco; Trisovic, Ana; Tsaregorodtsev, Andrei; Tsopelas, Panagiotis; Tuning, Niels; Ukleja, Artur; Ustyuzhanin, Andrey; Uwer, Ulrich; Vacca, Claudia; Vagnoni, Vincenzo; Valat, Sebastien; Valenti, Giovanni; Vallier, Alexis; Vazquez Gomez, Ricardo; Vazquez Regueiro, Pablo; Vázquez Sierra, Carlos; Vecchi, Stefania; van Veghel, Maarten; Velthuis, Jaap; Veltri, Michele; Veneziano, Giovanni; Vesterinen, Mika; Viaud, Benoit; Vieira, Daniel; Vieites Diaz, Maria; Vilasis-Cardona, Xavier; Volkov, Vladimir; Vollhardt, Achim; Voong, David; Vorobyev, Alexey; Vorobyev, Vitaly; Voß, Christian; de Vries, Jacco; Waldi, Roland; Wallace, Charlotte; Wallace, Ronan; Walsh, John; Wang, Jianchun; Ward, David; Watson, Nigel; Websdale, David; Weiden, Andreas; Whitehead, Mark; Wicht, Jean; Wilkinson, Guy; Wilkinson, Michael; Williams, Mark Richard James; Williams, Matthew; Williams, Mike; Williams, Timothy; Wilson, Fergus; Wimberley, Jack; Wishahi, Julian; Wislicki, Wojciech; Witek, Mariusz; Wormser, Guy; Wotton, Stephen; Wraight, Kenneth; Wright, Simon; Wyllie, Kenneth; Xie, Yuehong; Xu, Zhirui; Yang, Zhenwei; Yin, Hang; Yu, Jiesheng; Yuan, Xuhao; Yushchenko, Oleg; Zangoli, Maria; Zavertyaev, Mikhail; Zhang, Liming; Zhang, Yanxi; Zhelezov, Alexey; Zheng, Yangheng; Zhokhov, Anatoly; Zhong, Liang; Zhukov, Valery; Zucchelli, Stefano

    2016-01-01

    A search is performed for the charmless three-body decays of the $\\Lambda_b^0$ and $\\Xi_b^0$ baryons to the final states $\\Lambda h^+h^{\\prime -}$, where $h^{(\\prime)} = \\pi$ or $K$. The analysis is based on a data sample, corresponding to an integrated luminosity of $3 \\rm fb^{-1}$ of $pp$ collisions, collected by the LHCb experiment. The $\\Lambda_b^0 \\to \\Lambda K^+\\pi^-$ and $\\Lambda_b^0 \\to \\Lambda K^+K^-$ decays are observed for the first time and their branching fractions and $CP$ asymmetry parameters are measured. Evidence is seen for the $\\Lambda_b^0 \\to \\Lambda \\pi^+\\pi^-$ decay and limits are set on the branching fractions of $\\Xi_b^0$ baryon decays to the $\\Lambda h^+h^{\\prime -}$ final states.

  18. Pathogen detection using engineered bacteriophages.

    Science.gov (United States)

    Smartt, Abby E; Xu, Tingting; Jegier, Patricia; Carswell, Jessica J; Blount, Samuel A; Sayler, Gary S; Ripp, Steven

    2012-04-01

    Bacteriophages, or phages, are bacterial viruses that can infect a broad or narrow range of host organisms. Knowing the host range of a phage allows it to be exploited in targeting various pathogens. Applying phages for the identification of microorganisms related to food and waterborne pathogens and pathogens of clinical significance to humans and animals has a long history, and there has to some extent been a recent revival in these applications as phages have become more extensively integrated into novel detection, identification, and monitoring technologies. Biotechnological and genetic engineering strategies applied to phages are responsible for some of these new methods, but even natural unmodified phages are widely applicable when paired with appropriate innovative detector platforms. This review highlights the use of phages as pathogen detector interfaces to provide the reader with an up-to-date inventory of phage-based biodetection strategies.

  19. Host receptors for bacteriophage adsorption.

    Science.gov (United States)

    Bertozzi Silva, Juliano; Storms, Zachary; Sauvageau, Dominic

    2016-02-01

    The adsorption of bacteriophages (phages) onto host cells is, in all but a few rare cases, a sine qua non condition for the onset of the infection process. Understanding the mechanisms involved and the factors affecting it is, thus, crucial for the investigation of host-phage interactions. This review provides a survey of the phage host receptors involved in recognition and adsorption and their interactions during attachment. Comprehension of the whole infection process, starting with the adsorption step, can enable and accelerate our understanding of phage ecology and the development of phage-based technologies. To assist in this effort, we have established an open-access resource--the Phage Receptor Database (PhReD)--to serve as a repository for information on known and newly identified phage receptors. PMID:26755501

  20. Nucleon strange $s\\bar s$ asymmetry to the $\\Lambda/\\bar\\Lambda$ fragmentation

    CERN Document Server

    Chi, Yujie; Ma, Bo-Qiang

    2014-01-01

    The difference between the $\\Lambda$ and $\\bar \\Lambda$ longitudinal spin transfers in the semi-inclusive deep inelastic scattering process is intensively studied. The study is performed in the current fragmentation region, by considering the intermediate hyperon decay processes and sea quark fragmentation processes, while the strange sea $s\\bar s$ asymmetry in the nucleon is taken into account. The calculation in the light-cone quark-diquark model shows that the strange sea asymmetry gives a proper trend to the difference between the $\\Lambda$ and $\\bar \\Lambda$ longitudinal spin transfers. When considering the nonzero final hadron transverse momentum, our results can explain the COMPASS data reasonably. The nonzero final hadron transverse momentum is interpreted as a natural constraint to the final hadron $z$ range where the longitudinal spin transfer is more sensitive to the strange sea $s\\bar s$ asymmetry.

  1. $K^0 \\Lambda$ and $D^- \\Lambda_c^+$ production induced by pion beams off the nucleon

    CERN Document Server

    Kim, Sang-Ho; Hosaka, Atsushi

    2016-01-01

    We present a comparative study of the pion induced production of $K^0 \\Lambda$ and $D^- \\Lambda_c^+$ off the nucleon. A hybrid framework is utilized by combining an effective Lagrangian method with a Regge approach. We consider the $t$-channel process in a plannar diagram by vector-meson Reggeon exchanges and the $u$-channel one in a non-planar diagram by baryon Reggeon exchanges. The present model reproduces the $K^0 \\Lambda$ production data well with a few parameters. Having fixed them, we predict the $D^- \\Lambda_c^+$ production, which turns out to be about $10^4-10^6$ times smaller than the strangeness one, depending on the kinematical regions.

  2. Analysis of the (1, lambda)-ES on the parabolic ridge.

    Science.gov (United States)

    Oyman, A I; Beyer, H G; Schwefel, H P

    2000-01-01

    The progress rate of the (1,+ lambda)-ES (Evolution Strategy) is analyzed on the parabolic ridge test function. A different progress behavior is observed for the (1, lambda)-ES than for the sphere model test function. The characteristics of the progress rate picture for the plus strategy differs little from the one obtained for the sphere model, but this strategy has drastically worse progress rate values than those obtained for the comma strategy. The dynamics of the distance to the progress axis is also investigated. A theoretical formula is derived to estimate the change in this distance over generations. This formula is used to derive the expected value of the problem-specific distance to the ridge axis. The correctness of the formulae is supported by simulation results.

  3. A Study of Parton Fragmentation in Hadronic $Z^{0}$ Decays Using $\\Lambda \\overline\\Lambda$ Correlations

    CERN Document Server

    Abbiendi, G; Alexander, Gideon; Allison, J; Altekamp, N; Anderson, K J; Anderson, S; Arcelli, S; Asai, S; Ashby, S F; Axen, D A; Azuelos, Georges; Ball, A H; Barberio, E; Barlow, R J; Bartoldus, R; Batley, J Richard; Baumann, S; Bechtluft, J; Behnke, T; Bell, K W; Bella, G; Bellerive, A; Bentvelsen, Stanislaus Cornelius Maria; Bethke, Siegfried; Betts, S; Biebel, O; Biguzzi, A; Bird, S D; Blobel, Volker; Bloodworth, Ian J; Bobinski, M; Bock, P; Böhme, J; Bonacorsi, D; Boutemeur, M; Braibant, S; Bright-Thomas, P G; Brigliadori, L; Brown, R M; Burckhart, Helfried J; Burgard, C; Bürgin, R; Capiluppi, P; Carnegie, R K; Carter, A A; Carter, J R; Chang, C Y; Charlton, D G; Chrisman, D; Ciocca, C; Clarke, P E L; Clay, E; Cohen, I; Conboy, J E; Cooke, O C; Couyoumtzelis, C; Coxe, R L; Cuffiani, M; Dado, S; Dallavalle, G M; Davis, R; De Jong, S; del Pozo, L A; de Roeck, A; Desch, Klaus; Dienes, B; Dixit, M S; Dubbert, J; Duchovni, E; Duckeck, G; Duerdoth, I P; Eatough, D; Estabrooks, P G; Etzion, E; Evans, H G; Fabbri, Franco Luigi; Fanti, M; Faust, A A; Fiedler, F; Fierro, M; Fleck, I; Folman, R; Fürtjes, A; Futyan, D I; Gagnon, P; Gary, J W; Gascon, J; Gascon-Shotkin, S M; Gaycken, G; Geich-Gimbel, C; Giacomelli, G; Giacomelli, P; Gibson, V; Gibson, W R; Gingrich, D M; Glenzinski, D A; Goldberg, J; Gorn, W; Grandi, C; Gross, E; Grunhaus, Jacob; Gruwé, M; Hanson, G G; Hansroul, M; Hapke, M; Harder, K; Hargrove, C K; Hartmann, C; Hauschild, M; Hawkes, C M; Hawkings, R; Hemingway, Richard J; Herndon, M; Herten, G; Heuer, R D; Hildreth, M D; Hill, J C; Hillier, S J; Hobson, P R; Höcker, Andreas; Homer, R James; Honma, A K; Horváth, D; Hossain, K R; Howard, R; Hüntemeyer, P; Igo-Kemenes, P; Imrie, D C; Ishii, K; Jacob, F R; Jawahery, A; Jeremie, H; Jimack, Martin Paul; Jones, C R; Jovanovic, P; Junk, T R; Karlen, D A; Kartvelishvili, V G; Kawagoe, K; Kawamoto, T; Kayal, P I; Keeler, Richard K; Kellogg, R G; Kennedy, B W; Klier, A; Kluth, S; Kobayashi, T; Kobel, M; Koetke, D S; Kokott, T P; Kolrep, M; Komamiya, S; Kowalewski, R V; Kress, T; Krieger, P; Von Krogh, J; Kühl, T; Kyberd, P; Lafferty, G D; Lanske, D; Lauber, J; Lautenschlager, S R; Lawson, I; Layter, J G; Lazic, D; Lee, A M; Lellouch, Daniel; Letts, J; Levinson, L; Liebisch, R; List, B; Littlewood, C; Lloyd, A W; Lloyd, S L; Loebinger, F K; Long, G D; Losty, Michael J; Ludwig, J; Liu, D; Macchiolo, A; MacPherson, A L; Mader, W F; Mannelli, M; Marcellini, S; Markopoulos, C; Martin, A J; Martin, J P; Martínez, G; Mashimo, T; Mättig, P; McDonald, W J; McKenna, J A; McKigney, E A; McMahon, T J; McPherson, R A; Meijers, F; Menke, S; Merritt, F S; Mes, H; Meyer, J; Michelini, Aldo; Mihara, S; Mikenberg, G; Miller, D J; Mir, R; Mohr, W; Montanari, A; Mori, T; Nagai, K; Nakamura, I; Neal, H A; Nellen, B; Nisius, R; O'Neale, S W; Oakham, F G; Odorici, F; Ögren, H O; Oreglia, M J; Orito, S; Pálinkás, J; Pásztor, G; Pater, J R; Patrick, G N; Patt, J; Pérez-Ochoa, R; Petzold, S; Pfeifenschneider, P; Pilcher, J E; Pinfold, James L; Plane, D E; Poffenberger, P R; Polok, J; Przybycien, M B; Rembser, C; Rick, Hartmut; Robertson, S; Robins, S A; Rodning, N L; Roney, J M; Roscoe, K; Rossi, A M; Rozen, Y; Runge, K; Runólfsson, O; Rust, D R; Sachs, K; Saeki, T; Sahr, O; Sang, W M; Sarkisyan-Grinbaum, E; Sbarra, C; Schaile, A D; Schaile, O; Scharf, F; Scharff-Hansen, P; Schieck, J; Schmitt, B; Schmitt, S; Schmitz, R E; Schöning, A; Schröder, M; Schumacher, M; Schwick, C; Scott, W G; Seuster, R; Shears, T G; Shen, B C; Shepherd-Themistocleous, C H; Sherwood, P; Siroli, G P; Sittler, A; Skuja, A; Smith, A M; Snow, G A; Sobie, Randall J; Söldner-Rembold, S; Sproston, M; Stahl, A; Stephens, K; Steuerer, J; Stoll, K; Strom, D; Ströhmer, R; Surrow, B; Talbot, S D; Tanaka, S; Taras, P; Tarem, S; Teuscher, R; Thiergen, M; Thomson, M A; Von Törne, E; Torrence, E; Towers, S; Trigger, I; Trócsányi, Z L; Tsur, E; Turcot, A S; Turner-Watson, M F; Van Kooten, R; Vannerem, P; Verzocchi, M; Voss, H; Wäckerle, F; Wagner, A; Ward, C P; Ward, D R; Watkins, P M; Watson, A T; Watson, N K; Wells, P S; Wermes, N; White, J S; Wilson, G W; Wilson, J A; Wyatt, T R; Yamashita, S; Yekutieli, G; Zacek, V; Zer-Zion, D

    2000-01-01

    The correlated production of Lambda and Lambdabar baryons has been studied using 4.3 million multihadronic Zo decays recorded with the OPAL detector at LEP. Di-lambda pairs were investigated in the full data sample and for the first time also in 2-jet and 3-jet events selected with the k_t algorithm. The distributions of rapidity differences from correlated Lambda-Lambdabar pairs exhibit short-range, local correlations and prove to be a sensitive tool to test models, particularly for 2-jet events. The JETSET model describes the data best but some extra parameter tuning is needed to improve agreement with the experimental results in the rates and the rapidity spectra simultaneously. The recently developed modification of JETSET, the MOdified Popcorn Scenarium (MOPS), and also HERWIG do not give satisfactory results. This study of di-lambda production in 2- and 3-jet events supports the short-range compensation of quantum numbers.

  4. Lambda_b -> Lambda l+ l- decay within family non-universal Z' model

    OpenAIRE

    Aliev, T. M.; Savci, M.

    2012-01-01

    We perform a comprehensive analysis of the rare "Lambda_b -> Lambda l+ l-" decay in the framework of family non-universal Z' model. It is shown that Z' gives considerable contribution to the decay width. Zero positions of the forward-backward asymmetry and alpha_theta parameter are shifted to the left compared to the Standard Model result. The obtained results could be tested in near future at LHC-b.

  5. Improved Measurement of the Form Factors in the Decay Lambda_c^+ --> Lambda e^+ nu_e

    CERN Document Server

    Hinson, J W; Lee, J; Miller, D H; Pavlunin, V; Rangarajan, R; Sanghi, B; Shibata, E I; Shipsey, I P J; Cronin-Hennessy, D; Park, C S; Park, W; Thayer, J B; Thorndike, E H; Coan, T E; Gao, Y S; Liu, F; Stroynowski, R; Artuso, M; Boulahouache, C; Blusk, S; Dambasuren, E; Dorjkhaidav, O; Mountain, R; Muramatsu, H; Nandakumar, R; Skwarnicki, T; Stone, S; Wang, J C; Csorna, S E; Danko, I; Bonvicini, G; Cinabro, D; Dubrovin, M; McGee, S; Bornheim, A; Lipeles, E; Pappas, S P; Shapiro, A; Sun, W M; Weinstein, A J; Briere, R A; Chen, G P; Ferguson, T; Tatishvili, G T; Vogel, H; Watkins, M E; Adam, N E; Alexander, J P; Berkelman, K; Boisvert, V; Cassel, D G; Duboscq, J E; Ecklund, K M; Ehrlich, R; Galik, R S; Gibbons, L; Gittelman, B; Gray, S W; Hartill, D L; Heltsley, B K; Hsu, L; Jones, C D; Kandaswamy, J; Kreinick, D L; Magerkurth, A; Mahlke-Krüger, H; Meyer, T O; Mistry, N B; Patterson, J R; Peterson, D; Pivarski, J; Richichi, S J; Riley, D; Sadoff, A J; Schwarthoff, H; Shepherd, M R; Thayer, J G; Urner, D; Wilksen, T; Warburton, A; Weinberger, M; Athar, S B; Avery, P; Breva-Newell, L; Potlia, V; Stöck, H; Yelton, J; Benslama, K; Cawlfield, C; Eisenstein, B I; Gollin, G D; Karliner, I; Lowrey, N; Plager, C; Sedlack, C; Selen, M; Thaler, J J; Williams, J; Edwards, K W; Besson, D; Anderson, S; Frolov, V V; Gong, D T; Kubota, Y; Li, S Z; Poling, R A; Smith, A; Stepaniak, C J; Urheim, J; Metreveli, Z V; Seth, K K; Tomaradze, A G; Zweber, P; Ahmed, S; Alam, M S; Ernst, J; Jian, L; Saleem, M; Wappler, F; Arms, K; Eckhart, E; Gan, K K; Gwon, C; Honscheid, K; Kagan, H; Kass, R; Pedlar, T K; Von Törne, E; Severini, H; Skubic, P L; Dytman, S A; Müller, J A; Nam, S; Savinov, V

    2005-01-01

    Using the CLEO detector at the Cornell Electron Storage Ring, we have studied the distribution of kinematic variables in the decay Lambda_c^+ -> Lambda e^+ nu_e. By performing a four-dimensional maximum likelihood fit, we determine the form factor ratio, R = f_2/f_1 = -0.31 +/- 0.05(stat) +/- 0.04(syst), the pole mass, M_{pole} = (2.21 +/- 0.08(stat) +/- 0.14(syst)) GeV/c^2, and the decay asymmetry parameter of the Lambda_c, alpha_{Lambda_c} = -0.86 +/- 0.03(stat) +/- 0.02(syst), for = 0.67 (GeV/c^2)^2. We compare the angular distributions of the Lambda_c^+ and Lambda_c^- and find no evidence for CP-violation: A_{Lambda_c} = (alpha_{Lambda_c^+} + alpha_{Lambda_c^-})/ (alpha_{Lambda_c^+} - alpha_{Lambda_c^-}) = 0.00 +/- 0.03(stat) +/- 0.01(syst) +/- 0.02, where the third error is from the uncertainty in the world average of the CP-violating parameter, A_{Lambda}, for Lambda -> p pi^-.

  6. MULTI-LAMBDA MATTER IN A CHIRAL HADRONIC MODEL

    Institute of Scientific and Technical Information of China (English)

    郭华; 杨树; 胡翔; 刘玉鑫

    2001-01-01

    Multi-lambda matter is investigated in the framework of a chiral hadronic model It is shown that multi-lambda matter consisting of {N, A} is a metastable state as the strangeness per baryon and the density of hadronic matter are varied. The effective lambda mass decreases as the baryon density increases, and remains larger than that of the nucleon.

  7. Study of the decay asymmetry parameter and CP violation parameter in the Lambda(c)+ ---> Lambda pi+ decay

    Energy Technology Data Exchange (ETDEWEB)

    Link, J.M.; Yager, P.M.; /UC, Davis; Anjos, J.C.; Bediaga, I.; Castromonte, C.; Machado, A.A.; Magnin, J.; Massafferri, A.; de Miranda, J.M.; Pepe, I.M.; Polycarpo, E.; dos Reis, A.C.; /Rio de Janeiro, CBPF; Carrillo, S.; Casimiro, E.; Cuautle, E.; Sanchez-Hernandez, A.; Uribe, C.; Vazquez, F.; /CINVESTAV, IPN; Agostino, L.; Cinquini, L.; Cumalat,; /Colorado U. /Fermilab /Frascati /Guanajuato U. /Illinois U., Urbana /Indiana U. /Korea U. /Kyungpook Natl. U. /INFN, Milan /Milan U. /North Carolina U. /Pavia U. /INFN,

    2005-09-01

    Using data from the FOCUS (E831) experiment at Fermilab, we present a new measurement of the weak decay-asymmetry parameter a{sub {Lambda}{sub c}} in {Lambda}{sub c}{sup +} {yields} {Lambda}{pi}{sup +} decay. Comparing particle with antiparticle decays, we obtain the first measurement of the CP violation parameter {Alpha} {triple_bond} a{sub {Lambda}{sub c}} + a{sub {ovr {Lambda}{sub c}}}/a{sub {Lambda}{sub c}} - a{sub {ovr {Lambda}{sub c}}}. We obtain a{sub {Lambda}{sub c}} = -0.78 {+-} 0.16 {+-} 0.13 and {Alpha} = -0.07 {+-} 0.19 {+-} 0.12 where errors are statistical and systematic.

  8. Measurement of the Branching Fraction and Lambda-bar Polarization in B0 -> Lambda-par p pi-

    Energy Technology Data Exchange (ETDEWEB)

    Aubert, B.; Karyotakis, Y.; Lees, J.P.; Poireau, V.; Prencipe, E.; Prudent, X.; Tisserand, V.; /Annecy, LAPP; Garra Tico, J.; Grauges, E.; /Barcelona U., ECM; Martinelli, M.; Palano, A.; Pappagallo, M.; /INFN, Bari /Bari U.; Eigen, G.; Stugu, B.; Sun, L.; /Bergen U.; Battaglia, M.; Brown, D.N.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G.; Osipenkov, I.L.; /LBL, Berkeley /UC, Berkeley /Birmingham U. /Ruhr U., Bochum /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UC, Riverside /UC, San Diego /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /Frascati /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /Harvard U. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa U. /Iowa State U. /Johns Hopkins U. /Orsay, LAL /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT, LNS /McGill U. /INFN, Milan /Milan U. /INFN, Milan /INFN, Milan /Milan U. /Mississippi U. /Montreal U. /Mt. Holyoke Coll. /INFN, Naples /Naples U. /INFN, Naples /INFN, Naples /Naples U. /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /Padua U. /Paris U., VI-VII /Pennsylvania U. /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa, Scuola Normale Superiore /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /Rostock U. /Rutherford /DAPNIA, Saclay /SLAC /South Carolina U. /Stanford U., Phys. Dept. /SUNY, Albany /Tel Aviv U. /Tennessee U. /Texas U. /Texas U., Dallas /INFN, Turin /Turin U. /INFN, Trieste /Trieste U. /Valencia U., IFIC /Victoria U. /Warwick U. /Wisconsin U., Madison

    2009-08-03

    We present a measurement of the B{sup 0} {yields} {bar {Lambda}}p{pi}{sup -} branching fraction performed using the BABAR detector at the PEP-II asymmetric e{sup +}e{sup -} collider. Based on a sample of 467 x 10{sup 6} B{bar B} pairs we measure {Beta}(B{sup 0} {yields} {bar {Lambda}}p{pi}{sup -}) [3.07 {+-} 0.31(stat.) {+-} 0.23(syst.)] x 10{sup -6}. The measured differential spectrum as a function of the dibaryon invariant mass m({bar {Lambda}}p) shows a near-threshold enhancement similar to that observed in other baryonic B decays. We study the {bar {Lambda}} polarization as a function of {bar {Lambda}} energy in the B{sup 0} rest frame (E*{sub {bar {Lambda}}}) and compare it with theoretical expectations of fully longitudinally right-polarized {bar {Lambda}} at large E*{sub {bar {Lambda}}}.

  9. Complete Genome Sequence of Bacillus thuringiensis Bacteriophage BMBtp2

    OpenAIRE

    Dong, Zhaoxia; Peng, Donghai; Wang, Yueying; Zhu, Lei; Ruan, Lifang; Sun, Ming

    2013-01-01

    Bacillus thuringiensis is an insect pathogen which has been widely used for biocontrol. During B. thuringiensis fermentation, lysogenic bacteriophages cause severe losses of yield. Here, we announce the complete genome sequence of a bacteriophage, BMBtp2, which is induced from B. thuringiensis strain YBT-1765, which may be helpful to clarify the mechanism involved in bacteriophage contamination.

  10. 21 CFR 866.2050 - Staphylococcal typing bacteriophage.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Staphylococcal typing bacteriophage. 866.2050 Section 866.2050 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Staphylococcal typing bacteriophage. (a) Identification. A staphylococcal typing bacteriophage is a...

  11. Lambda Hypernuclei in a Chiral Hadronic Model

    Institute of Scientific and Technical Information of China (English)

    LIANG Yin-Hua; GUO Hua

    2005-01-01

    @@ Nuclear matter calculations in a chiral hadronic model have been performed. It has been found that the scalar and the vector potentials and binding energies per nucleon in the chiral hadronic model are very close to those of the microscopic relativistic Brueckner-Hartree-Fock calculations. The good results for finite nuclei can be obtained in the mean field approximation only if scalar mass ms and coupling constant gs have been improved with the fixed values of cs2 ≡ g2s(M/ms)2 as those given by the original parameter sets of the chiral hadronic model. Then the chiral hadronic model is extended to lambda hypernuclei. Our results predicted by the chiral hadronic model are compared with those by the nonlinear Walecka model. It has been shown that the hadronic model can also be used to describe lambda hypernuclei successfully.

  12. Measurement of $\\Lambda_{b}$ polarization in Z decays

    CERN Document Server

    Buskulic, Damir; De Bonis, I; Décamp, D; Ghez, P; Goy, C; Lees, J P; Lucotte, A; Minard, M N; Odier, P; Pietrzyk, B; Chmeissani, M; Crespo, J M; Efthymiopoulos, I; Fernández, E; Fernández-Bosman, M; Garrido, L; Juste, A; Martínez, M; Orteu, S; Pacheco, A; Padilla, C; Palla, Fabrizio; Pascual, A; Perlas, J A; Riu, I; Sánchez, F; Teubert, F; Colaleo, A; Creanza, D; De Palma, M; Farilla, A; Gelao, G; Girone, M; Iaselli, Giuseppe; Maggi, G; Maggi, M; Marinelli, N; Natali, S; Nuzzo, S; Ranieri, A; Raso, G; Romano, F; Ruggieri, F; Selvaggi, G; Silvestris, L; Tempesta, P; Zito, G; Huang, X; Lin, J; Ouyang, Q; Wang, T; Xie, Y; Xu, R; Xue, S; Zhang, J; Zhang, L; Zhao, W; Alemany, R; Bazarko, A O; Bonvicini, G; Cattaneo, M; Comas, P; Coyle, P; Drevermann, H; Forty, Roger W; Frank, M; Hagelberg, R; Harvey, J; Jacobsen, R; Janot, P; Jost, B; Kneringer, E; Knobloch, J; Lehraus, Ivan; Martin, E B; Mato, P; Minten, Adolf G; Miquel, R; Mir, L M; Moneta, L; Oest, T; Palazzi, P; Pater, J R; Pusztaszeri, J F; Ranjard, F; Rensing, P E; Rolandi, Luigi; Schlatter, W D; Schmelling, M; Schneider, O; Tejessy, W; Tomalin, I R; Venturi, A; Wachsmuth, H W; Wildish, T; Witzeling, W; Wotschack, J; Ajaltouni, Ziad J; Bardadin-Otwinowska, Maria; Barrès, A; Boyer, C; Falvard, A; Gay, P; Guicheney, C; Henrard, P; Jousset, J; Michel, B; Monteil, S; Montret, J C; Pallin, D; Perret, P; Podlyski, F; Proriol, J; Rossignol, J M; Saadi, F; Fearnley, Tom; Hansen, J B; Hansen, J D; Hansen, J R; Hansen, P H; Nilsson, B S; Kyriakis, A; Markou, C; Simopoulou, Errietta; Siotis, I; Vayaki, Anna; Zachariadou, K; Blondel, A; Bonneaud, G R; Brient, J C; Bourdon, P; Rougé, A; Rumpf, M; Tanaka, R; Valassi, Andrea; Verderi, M; Videau, H L; Candlin, D J; Parsons, M I; Focardi, E; Parrini, G; Corden, M; Delfino, M C; Georgiopoulos, C H; Jaffe, D E; Antonelli, A; Bencivenni, G; Bologna, G; Bossi, F; Campana, P; Capon, G; Chiarella, V; Felici, G; Laurelli, P; Mannocchi, G; Murtas, F; Murtas, G P; Passalacqua, L; Pepé-Altarelli, M; Curtis, L; Dorris, S J; Halley, A W; Knowles, I G; Lynch, J G; O'Shea, V; Raine, C; Reeves, P; Scarr, J M; Smith, K; Thompson, A S; Thomson, F; Thorn, S; Turnbull, R M; Becker, U; Braun, O; Geweniger, C; Graefe, G; Hanke, P; Hepp, V; Kluge, E E; Putzer, A; Rensch, B; Schmidt, M; Sommer, J; Stenzel, H; Tittel, K; Werner, S; Wunsch, M; Abbaneo, D; Beuselinck, R; Binnie, David M; Cameron, W; Colling, D J; Dornan, Peter J; Konstantinidis, N P; Moutoussi, A; Nash, J; San Martin, G; Sedgbeer, J K; Stacey, A M; Dissertori, G; Girtler, P; Kuhn, D; Rudolph, G; Bowdery, C K; Brodbeck, T J; Colrain, P; Crawford, G; Finch, A J; Foster, F; Hughes, G; Sloan, Terence; Whelan, E P; Williams, M I; Galla, A; Greene, A M; Kleinknecht, K; Quast, G; Raab, J; Renk, B; Sander, H G; Wanke, R; Van Gemmeren, P; Zeitnitz, C; Aubert, Jean-Jacques; Bencheikh, A M; Benchouk, C; Bonissent, A; Bujosa, G; Calvet, D; Carr, J; Diaconu, C A; Etienne, F; Thulasidas, M; Nicod, D; Payre, P; Rousseau, D; Talby, M; Abt, I; Assmann, R W; Bauer, C; Blum, Walter; Brown, D; Dietl, H; Dydak, Friedrich; Ganis, G; Gotzhein, C; Jakobs, K; Kroha, H; Lütjens, G; Lutz, Gerhard; Männer, W; Moser, H G; Richter, R H; Rosado-Schlosser, A; Schael, S; Settles, Ronald; Seywerd, H C J; Saint-Denis, R; Wiedenmann, W; Wolf, G; Boucrot, J; Callot, O; Cordier, A; Courault, F; Davier, M; Duflot, L; Grivaz, J F; Heusse, P; Jacquet, M; Kim, D W; Le Diberder, F R; Lefrançois, J; Lutz, A M; Nikolic, I A; Park, H J; Park, I C; Schune, M H; Simion, S; Veillet, J J; Videau, I; Azzurri, P; Bagliesi, G; Batignani, G; Bettarini, S; Bozzi, C; Calderini, G; Carpinelli, M; Ciocci, M A; Ciulli, V; Dell'Orso, R; Fantechi, R; Ferrante, I; Foà, L; Forti, F; Giassi, A; Giorgi, M A; Gregorio, A; Ligabue, F; Lusiani, A; Marrocchesi, P S; Messineo, A; Rizzo, G; Sanguinetti, G; Sciabà, A; Spagnolo, P; Steinberger, Jack; Tenchini, Roberto; Tonelli, G; Vannini, C; Verdini, P G; Walsh, J; Betteridge, A P; Blair, G A; Bryant, L M; Cerutti, F; Chambers, J T; Gao, Y; Green, M G; Johnson, D L; Medcalf, T; Perrodo, P; Strong, J A; Von Wimmersperg-Töller, J H; Botterill, David R; Clifft, R W; Edgecock, T R; Haywood, S; Edwards, M; Maley, P; Norton, P R; Thompson, J C; Bloch-Devaux, B; Colas, P; Emery, S; Kozanecki, Witold; Lançon, E; Lemaire, M C; Locci, E; Marx, B; Pérez, P; Rander, J; Renardy, J F; Roussarie, A; Schuller, J P; Schwindling, J; Trabelsi, A; Vallage, B; Johnson, R P; Kim, H Y; Litke, A M; McNeil, M A; Taylor, G; Beddall, A; Booth, C N; Boswell, R; Brew, C A J; Cartwright, S L; Combley, F; Köksal, A; Letho, M; Newton, W M; Rankin, C; Reeve, J; Thompson, L F; Böhrer, A; Brandt, S; Cowan, G D; Feigl, E; Grupen, Claus; Lutters, G; Minguet-Rodríguez, J A; Rivera, F; Saraiva, P; Smolik, L; Stephan, F; Apollonio, M; Bosisio, L; Della Marina, R; Giannini, G; Gobbo, B; Musolino, G; Ragusa, F; Rothberg, J E; Wasserbaech, S R; Armstrong, S R; Bellantoni, L; Elmer, P; Feng, Z; Ferguson, D P S; Gao, Y S; González, S; Grahl, J; Greening, T C; Harton, J L; Hayes, O J; Hu, H; McNamara, P A; Nachtman, J M; Orejudos, W; Pan, Y B; Saadi, Y; Schmitt, M; Scott, I J; Sharma, V; Turk, J; Walsh, A M; Wu Sau Lan; Wu, X; Yamartino, J M; Zheng, M; Zobernig, G

    1996-01-01

    The \\Lambda_{\\mathrm{b}} polarization in hadronic \\mathrm{Z} decays is measured in semileptonic decays from the average energies of the charged lepton and the neutrino. In a data sample of approximately 3 million hadronic \\mathrm{Z} decays collected by the ALEPH detector at LEP between 1991 and 1994, 462\\pm 31 \\Lambda_{\\mathrm{b}} candidates are selected using (\\Lambda \\pi^+)--lepton correlations. From this event sample, the \\Lambda_{\\m athrm{b}} polarization is measured to be \\cal P_{\\Lambda_{\\mathrm{b}}}=-0.23^{+0.24}_{-0.20}(\\m athrm{stat}.)^{+0.08}_{-0.07} (\\mathrm{syst.})\\,.

  13. Asymptotic behaviour of electro-$\\Lambda$ spacetimes

    CERN Document Server

    Saw, Vee-Liem

    2016-01-01

    We derive the asymptotic solutions for vacuum spacetimes with non-zero cosmological constant $\\Lambda$ coupled to Maxwell fields, using the Newman-Penrose formalism. This extends a recent work that dealt with the vacuum Einstein (Newman-Penrose) equations with $\\Lambda=0$. Using these asymptotic solutions, we discuss the mass-loss of an isolated electro-gravitating system with cosmological constant. In a universe with $\\Lambda>0$, the physics of electromagnetic (EM) radiation is relatively straightforward compared to those of gravitational radiation: 1) It is clear that outgoing EM radiation results in a decrease to the Bondi mass of the isolated system. 2) It is also perspicuous that if any incoming EM radiation from elsewhere is present, those beyond the isolated system's cosmological horizon would eventually arrive at the spacelike $\\mathcal{I}$ and increase the Bondi mass of the isolated system. Hence, the (outgoing and incoming) EM radiation fields do not couple with the Bondi mass-loss formula in any un...

  14. Spectroscopy of Lambda-9Li by electroproduction

    CERN Document Server

    Urciuoli, G M; Marrone, S; Acha, A; Ambrozewicz, P; Aniol, K A; Baturin, P; Bertin, P Y; Benaoum, H; Blomqvist, K I; Boeglin, W U; Breuer, H; Brindza, P; Bydzovsky, P; Camsonne, A; Chang, C C; Chen, J -P; Choi, Seonho; Chudakov, E A; Cisbani, E; Colilli, S; Coman, L; Craver, B J; De Cataldo, G; de Jager, C W; De Leo, R; Deur, A P; Ferdi, C; Feuerbach, R J; Folts, E; Fratoni, R; Frullani, S; Garibaldi, F; Gayou, O; Giuliani, F; Gomez, J; Gricia, M; Hansen, J O; Hayes, D; Higinbotham, D W; Holmstrom, T K; Hyde, C E; Ibrahim, H F; Iodice, M; Jiang, X; Kaufman, L J; Kino, K; Kross, B; Lagamba, L; LeRose, J J; Lindgren, R A; Lucentini, M; Margaziotis, D J; Markowitz, P; Meziani, Z E; McCormick, K; Michaels, R W; Millener, D J; Miyoshi, T; Moffit, B; Monaghan, P A; Moteabbed, M; Camacho, C Munoz; Nanda, S; Nappi, E; Nelyubin, V V; Norum, B E; Okasyasu, Y; Paschke, K D; Perdrisat, C F; Piasetzky, E; Punjabi, V A; Qiang, Y; Reimer, P E; Reinhold, J; Reitz, B; Roche, R E; Rodriguez, V M; Saha, A; Santavenere, F; Sarty, A J; Segal, J; Shahinyan, A; Singh, J; Sirca, S; Snyder, R; Solvignon, P H; Sotona, M; Subedi, R; Sulkosky, V A; Suzuki, T; Ueno, H; Ulmer, P E; Veneroni, P; Voutier, E; Wojtsekhowski, B B; Zheng, X; Zorn, C

    2014-01-01

    In the absence of accurate data on the free two-body hyperon-nucleon interaction, the spectra of hypernuclei can provide information on the details of the effective hyperon-nucleon interaction. Electroproduction of the hypernucleus Lambda-9Li has been studied for the first time with sub-MeV energy resolution in Hall A at Jefferson Lab on a 9Be target. In order to increase the counting rate and to provide unambiguous kaon identification, two superconducting septum magnets and a Ring Imaging CHerenkov detector (RICH) were added to the Hall A standard equipment. The cross section to low-lying states of Lambda-9Li is concentrated within 3 MeV of the ground state and can be fitted with four peaks. The positions of the doublets agree with theory while a disagreement could exist with respect to the relative strengths of the peaks in the doublets. A Lambda separation energy of 8.36 +- 0.08 (stat.) +- 0.08 (syst.) MeV was measured, in agreement with an earlier experiment.

  15. $\\Lambda_c-N$ interaction from lattice QCD

    CERN Document Server

    Miyamoto, Takaya

    2016-01-01

    We investigate the s-wave $\\Lambda_c-N$ interaction for spin singlet systems($^1S_0$) using the HAL QCD method. In our lattice QCD simulations, we employ gauge configurations generated by the PACS-CS Collaboration at $a = 0.0907(13)$ fm on a $32^3 \\times 64$ lattice ($La = 2.902(42)$ fm). We employ two ensembles, one at $m_\\pi = 700(1)$ MeV and the other at $m_\\pi = 570(1)$ MeV to study the quark mass dependence of the $\\Lambda_c-N$ interactions. We calculate a $^1S_0$ central potential not only for the $\\Lambda_c-N$ system but also for $\\Lambda-N$ system to understand the role of heavy charm quarks in $\\Lambda_c-N$ system. We find repulsion at short distance and attraction at mid-range for both the $\\Lambda_c-N$ and the $\\Lambda-N$ potentials. The short range repulsion of the $\\Lambda_c-N$ potential is smaller than that of the $\\Lambda-N$ potential, and the attraction of the $\\Lambda_c-N$ potential is small compared with the $\\Lambda-N$ potential. The phase shift and scattering length calculated with these p...

  16. Measurement of the Lambda_b lifetime using semileptonic decays

    CERN Document Server

    Abazov, V M; Abolins, M; Acharya, B S; Adams, M; Adams, T; Aguiló, E; Ahn, S H; Ahsan, M; Alexeev, G D; Alkhazov, G; Alton, A; Alverson, G; Alves, G A; Anastasoaie, M; Ancu, L S; Andeen, T; Anderson, S; Andrieu, B; Anzelc, M S; Arnoud, Y; Arov, M; Arthaud, M; Askew, A; Åsman, B; Assis-Jesus, A C S; Atramentov, O; Autermann, C; Avila, C; Ay, C; Badaud, F; Baden, A; Bagby, L; Baldin, B; Bandurin, D V; Banerjee, S; Banerjee, P; Barberis, E; Barfuss, A F; Bargassa, P; Baringer, P; Barreto, J; Bartlett, J F; Bassler, U; Bauer, D; Beale, S; Bean, A; Begalli, M; Begel, M; Belanger-Champagne, C; Bellantoni, L; Bellavance, A; Benítez, J A; Beri, S B; Bernardi, G; Bernhard, R; Berntzon, L; Bertram, I; Besançon, M; Beuselinck, R; Bezzubov, V A; Bhat, P C; Bhatnagar, V; Biscarat, C; Blazey, G; Blekman, F; Blessing, S; Bloch, D; Bloom, K; Böhnlein, A; Boline, D; Bolton, T A; Borissov, G; Bos, K; Bose, T; Brandt, A; Brock, R; Brooijmans, G; Bross, A; Brown, D; Buchanan, N J; Buchholz, D; Bühler, M; Büscher, V; Burdin, S; Burke, S; Burnett, T H; Buszello, C P; Butler, J M; Calfayan, P; Calvet, S; Cammin, J; Caron, S; Carvalho, W; Casey, B C K; Cason, N M; Castilla-Valdez, H; Chakrabarti, S; Chakraborty, D; Chan, K M; Chan, K; Chandra, A; Charles, F; Cheu, E; Chevallier, F; Cho, D K; Choi, S; Choudhary, B; Christofek, L; Christoudias, T; Cihangir, S; Claes, D; Clément, C; Clement, B; Coadou, Y; Cooke, M; Cooper, W E; Corcoran, M; Couderc, F; Cousinou, M C; Crepe-Renaudin, S; Cutts, D; Cwiok, M; Da Motta, H; Das, A; Davies, G; De, K; De Jong, S J; de Jong, P; De La Cruz-Burelo, E; De Oliveira Martins, C; Degenhardt, J D; Déliot, F; Demarteau, M; Demina, R; Denisov, D; Denisov, S P; Desai, S; Diehl, H T; Diesburg, M; Dominguez, A; Dong, H; Dudko, L V; Duflot, L; Dugad, S R; Duggan, D; Duperrin, A; Dyer, J; Dyshkant, A; Eads, M; Edmunds, D; Ellison, J; Elvira, V D; Enari, Y; Eno, S; Ermolov, P; Evans, H; Evdokimov, A; Evdokimov, V N; Ferapontov, A V; Ferbel, T; Fiedler, F; Filthaut, F; Fisher, W; Fisk, H E; Ford, M; Fortner, M; Fox, H; Fu, S; Fuess, S; Gadfort, T; Galea, C F; Gallas, E; Galyaev, E; García, C; García-Bellido, A; Gavrilov, V; Gay, P; Geist, W; Gelé, D; Gerber, C E; Gershtein, Yu; Gillberg, D; Ginther, G; Gollub, N; Gómez, B; Goussiou, A; Grannis, P D; Greenlee, H; Greenwood, Z D; Gregores, E M; Grenier, G; Gris, P; Grivaz, J F; Grohsjean, A; Grünendahl, S; Grünewald, M W; Guo, J; Guo, F; Gutíerrez, P; Gutíerrez, G; Haas, A; Hadley, N J; Haefner, P; Hagopian, S; Haley, J; Hall, I; Hall, R E; Han, L; Hanagaki, K; Hansson, P; Harder, K; Harel, A; Harrington, R; Hauptman, J M; Hauser, R; Hays, J; Hebbeker, T; Hedin, D; Hegeman, J G; Heinmiller, J M; Heinson, A P; Heintz, U; Hensel, C; Herner, K; Hesketh, G; Hildreth, M D; Hirosky, R; Hobbs, J D; Hoeneisen, B; Hoeth, H; Hohlfeld, M; Hong, S J; Hooper, R; Hossain, S; Houben, P; Hu, Y; Hubacek, Z; Hynek, V; Iashvili, I; Illingworth, R; Ito, A S; Jabeen, S; Jaffré, M; Jain, S; Jakobs, K; Jarvis, C; Jesik, R; Johns, K; Johnson, C; Johnson, M; Jonckheere, A; Jonsson, P; Juste, A; Käfer, D; Kahn, S; Kajfasz, E; Kalinin, A M; Kalk, J R; Kalk, J M; Kappler, S; Karmanov, D; Kasper, J; Kasper, P; Katsanos, I; Kau, D; Kaur, R; Kaushik, V; Kehoe, R; Kermiche, S; Khalatyan, N; Khanov, A; Kharchilava, A; Kharzheev, Yu M; Khatidze, D; Kim, H; Kim, T J; Kirby, M H; Kirsch, M; Klima, B; Kohli, J M; Konrath, J P; Kopal, M; Korablev, V M; Kothari, B; Kozelov, A V; Krop, D; Kryemadhi, A; Kühl, T; Kumar, A; Kunori, S; Kupco, A; Kurca, T; Kvita, J; Lacroix, F; Lam, D; Lammers, S; Landsberg, G L; Lazoflores, J; Lebrun, P; Lee, W M; Leflat, A; Lehner, F; Lellouch, J; Lesne, V; Lévêque, J; Lewin, M; Lewis, P; Li, J; Li, Q Z; Li, L; Lietti, S M; Lima, J G R; Lincoln, D; Linnemann, J; Lipaev, V V; Lipton, R; Liu, Y; Liu, Z; Lobo, L; Lobodenko, A; Lokajícek, M; Lounis, A; Love, P; Lubatti, H J; Lyon, A L; Maciel, A K A; Mackin, D; Madaras, R J; Mättig, P; Magass, C; Magerkurth, A; Makovec, N; Mal, P K; Malbouisson, H B; Malik, S; Malyshev, V L; Mao, H S; Maravin, Y; Martin, B; McCarthy, R; Melnitchouk, A; Mendes, A; Mendoza, L; Mercadante, P G; Merkin, M; Merritt, K W; Meyer, J; Meyer, A; Michaut, M; Millet, T; Mitrevski, J; Molina, J; Mommsen, R K; Mondal, N K; Moore, R W; Moulik, T; Muanza, G S; Mulders, M; Mulhearn, M; Mundal, O; Mundim, L; Nagy, E; Naimuddin, M; Narain, M; Naumann, N A; Neal, H A; Negret, J P; Neustroev, P; Nilsen, H; Nomerotski, A; Novaes, S F; Nunnemann, T; O'Dell, V; O'Neil, D C; Obrant, G; Ochando, C; Onoprienko, D; Oshima, N; Osta, J; Otec, R; Oteroy-Garzon, G J; Owen, M; Padley, P; Pangilinan, M; Parashar, N; Park, S J; Park, S K; Parsons, J; Partridge, R; Parua, N; Patwa, A; Pawloski, G; Penning, B; Perea, P M; Peters, K; Peters, Y; Petroff, P; Petteni, M; Piegaia, R; Piper, J; Pleier, M A; Podesta-Lerma, P L M; Podstavkov, V M; Pogorelov, Y; Pol, M E; Polozov, P; Pompo, A; Pope, B G; Popov, A V; Potter, C; Prado da Silva, W L; Prosper, H B; Protopopescu, S D; Qian, J; Quadt, A; Quinn, B; Rakitine, A; Rangel, M S; Rani, K J; Ranjan, K; Ratoff, P N; Renkel, P; Reucroft, S; Rich, P; Rijssenbeek, M; Ripp-Baudot, I; Rizatdinova, F K; Robinson, S; Rodrigues, R F; Royon, C; Rubinov, P; Ruchti, R; Safronov, G; Sajot, G; Sánchez-Hernández, A; Sanders, M P; Santoro, A F S; Savage, G; Sawyer, L; Scanlon, T; Schaile, A D; Schamberger, R D; Scheglov, Y; Schellman, H; Schieferdecker, P; Schliephake, T; Schmitt, C; Schwanenberger, C; Schwartzman, A; Schwienhorst, R; Sekaric, J; Sen-Gupta, S; Severini, H; Shabalina, E; Shamim, M; Shary, V; Shchukin, A A; Shivpuri, R K; Shpakov, D; Siccardi, V; Simák, V; Sirotenko, V I; Skubic, P L; Slattery, P F; Smirnov, D; Smith, R P; Snow, J; Snow, G R; Snyder, S; Söldner-Rembold, S; Sonnenschein, L; Sopczak, A; Sosebee, M; Soustruznik, K; Souza, M; Spurlock, B; Stark, J; Steele, J; Stolin, V; Stone, A; Stoyanova, D A; Strandberg, J; Strandberg, S; Strang, M A; Strauss, M; Strauss, E; Ströhmer, R; Strom, D; Strovink, M; Stutte, L; Sumowidagdo, S; Svoisky, P; Sznajder, A; Talby, M; Tamburello, P; Tanasijczuk, A; Taylor, W; Telford, P; Temple, J; Tiller, B; Tissandier, F; Titov, M; Tokmenin, V V; Tomoto, M; Toole, T; Torchiani, I; Trefzger, T; Tsybychev, D; Tuchming, B; Tully, C; Tuts, P M; Unalan, R; Uvarov, S; Uvarov, L; Uzunyan, S; Vachon, B; Van den Berg, P J; van Eijk, B; Van Kooten, R; Van Leeuwen, W M; Varelas, N; Varnes, E W; Vartapetian, A; Vasilyev, I A; Vaupel, M; Verdier, P; Vertogradov, L S; Verzocchi, M; Villeneuve-Séguier, F; Vint, P; Vokac, P; Von Törne, E; Voutilainen, M; Vreeswijk, M; Wagner, R; Wahl, H D; Wang, L; Wang, M H L; Warchol, J; Watts, G; Wayne, M; Weber, M; Weber, G; Weerts, H; Wenger, A; Wermes, N; Wetstein, M; White, A; Wicke, D; Wilson, G W; Wimpenny, S J; Wobisch, M; Wood, D R; Wyatt, T R; Xie, Y; Yacoob, S; Yamada, R; Yan, M; Yasuda, T; Yatsunenko, Y A; Yip, K; Yoo, H D; Youn, S W; Yu, J; Yu, C; Yurkewicz, A; Zatserklyaniy, A; Zeitnitz, C; Zhang, D; Zhao, T; Zhou, B; Zhu, J; Zielinski, M; Zieminska, D; Zieminski, A; Zivkovic, L; Zutshi, V; Zverev, E G

    2007-01-01

    We report a measurement of the Lambda_b lifetime using a sample corresponding to 1.3 fb$^{-1}$ of data collected by the D0 experiment in 2002--2006 during Run II of the Fermilab Tevatron collider. The Lambda_b baryon is reconstructed via the decay Lambda_b -> mu nu Lambda_c X. Using $4437 \\pm 329$ signal candidates, we measure the Lambda_b lifetime to be $\\tau(Lambda_b)$ = 1.290^{+0.119}_{-0.110}(stat) ^{+0.087}_{-0.091} (syst) ps, which is among the most precise measurements in semileptonic Lambda_b decays. This result is in good agreement with the world average value.

  17. Dynamical system approach to running $\\Lambda$ cosmological models

    CERN Document Server

    Stachowski, Aleksander

    2016-01-01

    We discussed the dynamics of cosmological models in which the cosmological constant term is a time dependent function through the scale factor $a(t)$, Hubble function $H(t)$, Ricci scalar $R(t)$ and scalar field $\\phi(t)$. We considered five classes of models; two non-covariant parametrization of $\\Lambda$: 1) $\\Lambda(H)$CDM cosmologies where $H(t)$ is the Hubble parameter, 2) $\\Lambda(a)$CDM cosmologies where $a(t)$ is the scale factor, and three covariant parametrization of $\\Lambda$: 3) $\\Lambda(R)$CDM cosmologies, where $R(t)$ is the Ricci scalar, 4) $\\Lambda(\\phi)$-cosmologies with diffusion, 5) $\\Lambda(X)$-cosmologies, where $X=\\frac{1}{2}g^{\\alpha\\beta}\

  18. Trivalent iron induced gelation in lambda-carrageenan

    Energy Technology Data Exchange (ETDEWEB)

    Running, Cordelia A.; Falshaw, Ruth; Janaswamy, Srinivas (Purdue)

    2012-05-24

    This communication reports gelation of lambda-carrageenan, for the first time, in the presence of trivalent iron ions. Kappa-, iota- and lambda-carrageenans are sulfated polysaccharides used extensively in food, pharmaceutical and medical applications. Kappa- and iota-carrageenans show gelation in the presence of mono- and di-valent ions, but lambda-carrageenan yields only viscous solutions. Our results show that gelation in lambda-carrageenan indeed is possible, but with trivalent ions. X-ray fiber diffraction patterns of iron (III)-lambda-carrageenan are characteristic of highly oriented and polycrystalline fibers containing well resolved Bragg reflections. The elastic modulus (G*) of the product is far greater than the loss modulus (G*) indicating the thermal stability of lambda-carrageenan in the presence of iron (III) ions. This novel finding has potential to expand lambda-carrageenan's current utility beyond a viscosifying agent.

  19. Rare baryon decays Lambda_b -> Lambda l+ l- (l=e, mu, tau) and Lambda_b -> Lambda gamma : differential and total rates, lepton- and hadron-side forward-backward asymmetries

    CERN Document Server

    Gutsche, Thomas; Korner, Jurgen G; Lyubovitskij, Valery E; Santorelli, Pietro

    2013-01-01

    Using the covariant constituent quark model previously developed by us we calculate the differential rate and the forward-backward asymmetries on the lepton and hadron side for the rare baryon decays Lambda_b -> Lambda l+ l- (l=e, mu, tau) and Lambda_b -> Lambda gamma. We use helicity methods to write down a three-fold joint angular decay distribution for the cascade decay Lambda_b -> Lambda (-> p pi-) + J_eff (-> l+ l-). Through appropriate angular integrations we obtain expressions for the rates, the lepton-side forward-backward (FB) asymmetry and the polarization of the daughter baryon Lambda leading to a hadron-side forward-backward asymmetry. We present numerical results on these observables using the covariant quark model and compare our results to the results of other calculations that have appeared in the literature.

  20. Lambda0 polarization in p p ---> p Lambda0 K+ (pi+ pi-) at 27.5-GeV

    Energy Technology Data Exchange (ETDEWEB)

    Felix, J.; Christian, D.C.; Church, M.D.; Forbush, M.; Gottschalk, E.E.; Gutierrez, G.; Hartouni, E.P.; Holmes, Stephen D.; Huson, F.R.; Jensen, D.A.; Knapp, B.C.; Kreisler, M.N.; Uribe, J.; Stern, B.J.; Wang, M.H.L.S.; Wehmann, A.; Wiencke, L.R.; White, J.T.; /Guanajuato U. /Fermilab /Nevis Labs, Columbia U. /Texas A-M /Massachusetts U.,

    2004-10-01

    The polarization of 1973 {Lambda}{sup 0}'s from the specific reaction pp {yields} p{Lambda}{sup 0}K{sup +}({pi}{sup +}{pi}{sup -}){sup 5} created by 27.5 Gev incident protons on a liquid hydrogen target, as a function of {chi}{sub F}, P{sub T}, and M{sub {Lambda}{sup 0}K{sup +}}, is, within statistics, consistent with the polarization of {Lambda}{sup 0}'s from pp {yields} P{sub fast} {Lambda}{sup 0}K{sup +} at 800 GeV.

  1. Understanding the enormous diversity of bacteriophages: the tailed phages that infect the bacterial family Enterobacteriaceae

    Science.gov (United States)

    Grose, Julianne H.; Casjens, Sherwood R.

    2014-01-01

    Bacteriophages are the predominant biological entity on the planet. The recent explosion of sequence information has made estimates of their diversity possible. We describe the genomic comparison of 337 fully sequenced tailed phages isolated on 18 genera and 31 species of bacteria in the Enterobacteriaceae. These phages were largely unambiguously grouped into 56 diverse clusters (32 lytic and 24 temperate) that have syntenic similarity over >50% of the genomes within each cluster, but substantially less sequence similarity between clusters. Most clusters naturally break into sets of more closely related subclusters, 78% of which are correlated with their host genera. The largest groups of related phages are superclusters united by genome synteny to lambda (81 phages) and T7 (51 phages). This study forms a robust framework for understanding diversity and evolutionary relationships of existing tailed phages, for relating newly discovered phages and for determining host/phage relationships. PMID:25240328

  2. Understanding the enormous diversity of bacteriophages: the tailed phages that infect the bacterial family Enterobacteriaceae.

    Science.gov (United States)

    Grose, Julianne H; Casjens, Sherwood R

    2014-11-01

    Bacteriophages are the predominant biological entity on the planet. The recent explosion of sequence information has made estimates of their diversity possible. We describe the genomic comparison of 337 fully sequenced tailed phages isolated on 18 genera and 31 species of bacteria in the Enterobacteriaceae. These phages were largely unambiguously grouped into 56 diverse clusters (32 lytic and 24 temperate) that have syntenic similarity over >50% of the genomes within each cluster, but substantially less sequence similarity between clusters. Most clusters naturally break into sets of more closely related subclusters, 78% of which are correlated with their host genera. The largest groups of related phages are superclusters united by genome synteny to lambda (81 phages) and T7 (51 phages). This study forms a robust framework for understanding diversity and evolutionary relationships of existing tailed phages, for relating newly discovered phages and for determining host/phage relationships.

  3. Bacteriophage-Based Pathogen Detection

    Science.gov (United States)

    Ripp, Steven

    Considered the most abundant organism on Earth, at a population approaching 1031, bacteriophage, or phage for short, mediate interactions with myriad bacterial hosts that has for decades been exploited in phage typing schemes for signature identification of clinical, food-borne, and water-borne pathogens. With over 5,000 phage being morphologically characterized and grouped as to susceptible host, there exists an enormous cache of bacterial-specific sensors that has more recently been incorporated into novel bio-recognition assays with heightened sensitivity, specificity, and speed. These assays take many forms, ranging from straightforward visualization of labeled phage as they attach to their specific bacterial hosts to reporter phage that genetically deposit trackable signals within their bacterial hosts to the detection of progeny phage or other uniquely identifiable elements released from infected host cells. A comprehensive review of these and other phage-based detection assays, as directed towards the detection and monitoring of bacterial pathogens, will be provided in this chapter.

  4. Photodynamic Inactivation of Mammalian Viruses and Bacteriophages

    Directory of Open Access Journals (Sweden)

    Liliana Costa

    2012-06-01

    Full Text Available Photodynamic inactivation (PDI has been used to inactivate microorganisms through the use of photosensitizers. The inactivation of mammalian viruses and bacteriophages by photosensitization has been applied with success since the first decades of the last century. Due to the fact that mammalian viruses are known to pose a threat to public health and that bacteriophages are frequently used as models of mammalian viruses, it is important to know and understand the mechanisms and photodynamic procedures involved in their photoinactivation. The aim of this review is to (i summarize the main approaches developed until now for the photodynamic inactivation of bacteriophages and mammalian viruses and, (ii discuss and compare the present state of the art of mammalian viruses PDI with phage photoinactivation, with special focus on the most relevant mechanisms, molecular targets and factors affecting the viral inactivation process.

  5. Photodynamic inactivation of mammalian viruses and bacteriophages.

    Science.gov (United States)

    Costa, Liliana; Faustino, Maria Amparo F; Neves, Maria Graça P M S; Cunha, Angela; Almeida, Adelaide

    2012-07-01

    Photodynamic inactivation (PDI) has been used to inactivate microorganisms through the use of photosensitizers. The inactivation of mammalian viruses and bacteriophages by photosensitization has been applied with success since the first decades of the last century. Due to the fact that mammalian viruses are known to pose a threat to public health and that bacteriophages are frequently used as models of mammalian viruses, it is important to know and understand the mechanisms and photodynamic procedures involved in their photoinactivation. The aim of this review is to (i) summarize the main approaches developed until now for the photodynamic inactivation of bacteriophages and mammalian viruses and, (ii) discuss and compare the present state of the art of mammalian viruses PDI with phage photoinactivation, with special focus on the most relevant mechanisms, molecular targets and factors affecting the viral inactivation process.

  6. Biophysics and bioinformatics of transcription regulation in bacteria and bacteriophages

    Science.gov (United States)

    Djordjevic, Marko

    2005-11-01

    Due to rapid accumulation of biological data, bioinformatics has become a very important branch of biological research. In this thesis, we develop novel bioinformatic approaches and aid design of biological experiments by using ideas and methods from statistical physics. Identification of transcription factor binding sites within the regulatory segments of genomic DNA is an important step towards understanding of the regulatory circuits that control expression of genes. We propose a novel, biophysics based algorithm, for the supervised detection of transcription factor (TF) binding sites. The method classifies potential binding sites by explicitly estimating the sequence-specific binding energy and the chemical potential of a given TF. In contrast with the widely used information theory based weight matrix method, our approach correctly incorporates saturation in the transcription factor/DNA binding probability. This results in a significant reduction in the number of expected false positives, and in the explicit appearance---and determination---of a binding threshold. The new method was used to identify likely genomic binding sites for the Escherichia coli TFs, and to examine the relationship between TF binding specificity and degree of pleiotropy (number of regulatory targets). We next address how parameters of protein-DNA interactions can be obtained from data on protein binding to random oligos under controlled conditions (SELEX experiment data). We show that 'robust' generation of an appropriate data set is achieved by a suitable modification of the standard SELEX procedure, and propose a novel bioinformatic algorithm for analysis of such data. Finally, we use quantitative data analysis, bioinformatic methods and kinetic modeling to analyze gene expression strategies of bacterial viruses. We study bacteriophage Xp10 that infects rice pathogen Xanthomonas oryzae. Xp10 is an unusual bacteriophage, which has morphology and genome organization that most closely

  7. Differential Photoproduction Cross Sections of the Sigma0(1385), Lambda(1405), and Lambda(1520)

    Energy Technology Data Exchange (ETDEWEB)

    Moriya, Kei [Indiana U.; Schumacher, Reinhard A. [Carnegie Mellon U.

    2013-10-01

    We report the exclusive photoproduction cross sections for the Sigma(1385), Lambda(1405), and Lambda(1520) in the reactions gamma + p -> K+ + Y* using the CLAS detector for energies from near the respective production thresholds up to a center-of-mass energy W of 2.85 GeV. The differential cross sections are integrated to give the total exclusive cross sections for each hyperon. Comparisons are made to current theoretical models based on the effective Lagrangian approach and fitted to previous data. The accuracy of these models is seen to vary widely. The cross sections for the Lambda(1405) region are strikingly different for the Sigma+pi-, Sigma0 pi0, and Sigma- pi+ decay channels, indicating the effect of isospin interference, especially at W values close to the threshold.

  8. Antiviral effect of cationic compounds on bacteriophages

    Directory of Open Access Journals (Sweden)

    Mai Huong eChatain-Ly

    2013-03-01

    Full Text Available The antiviral activity of several cationic compounds - cetytrimethylammonium (CTAB, chitosan, nisin and lysozyme - was investigated on the bacteriophage c2 (DNA head and non-contractile tail infecting Lactococcus strains and the bacteriophage MS2 (F-specific RNA infecting E.coli. Firstly, these activities were evaluated in a phosphate buffer pH 7- 10 mM. The CTAB had a virucidal effect on the Lactococcus bacteriophages, but not on the MS2. After 1 min of contact with 0.125 mM CTAB, the c2 population was reduced from 6 log(pfu/mL to 1,5 log(pfu/mL and completely deactivated at 1 mM. On the contrary, chitosan inhibited the MS2 more than it did the bacteriophages c2. No antiviral effect was observed for the nisin or the lysozyme on bacteriophages after 1 min of treatment. A 1 and 2.5 log reduction was respectively observed for nisin and lysozyme when the treatment time increased (5 or 10 min. These results showed that the antiviral effect depended both on the virus and structure of the antimicrobial compounds. The antiviral activity of these compounds was also evaluated in different physico-chemical conditions and in complex matrices. The antiviral activity of CTAB was impaired in acid pH and with an increase of the ionic strength. These results might be explained by the electrostatic interactions between cationic compounds and negatively charged particles such as bacteriophages or other compounds in a matrix. Milk proved to be protective suggesting the components of food could interfere with antimicrobial compounds.

  9. Pentaquarks from intrinsic charms in $\\Lambda_b$ decays

    CERN Document Server

    Hsiao, Y K

    2015-01-01

    We study the three-body $\\Lambda_b$ decays of $\\Lambda_b\\to J/\\psi pM$ with $M=K^-$ and $\\pi^-$. The two new states ${\\cal P}_{c1}\\equiv {\\cal P}_c(4380)^+$ and ${\\cal P}_{c2}\\equiv {\\cal P}_c(4450)^+$ observed recently as the resonances in the $J/\\psi p$ invariant mass spectrum of $\\Lambda_b\\to J/\\psi p K^-$ can be identified to consist of five quarks, $uudc\\bar c$, being consistent with the existence of the pentaquark states. We argue that, in the doubly charmful $\\Lambda_b$ decays of $\\Lambda_b\\to J/\\psi pK^-$ through $b\\to c\\bar c s$, apart from those through the non-resonant $\\Lambda_b\\to pK^-$ and resonant $\\Lambda_b\\to \\Lambda^*\\to pK^-$ transitions, the third contribution with the non-factorizable effects is not the dominant part for the resonant $\\Lambda_b\\to K^-{\\cal P}_{c1,c2}, {\\cal P}_{c1,c2}\\to J/\\psi p$ processes, such that we propose that the ${\\cal P}_{c1,c2}$ productions are mainly from the charmless $\\Lambda_b$ decays through $b\\to \\bar u u s$, in which the $c\\bar c$ content in ${\\cal P}_{c...

  10. Production of charmed baryon $\\Lambda_c(2940)^+$ at PANDA

    CERN Document Server

    He, Jun; Liu, Xiang; Li, Xue-Qian

    2011-01-01

    In this work we evaluate the production rate of the charmed baryon $\\Lambda_c(2940)^+$ at PANDA. For possible assignments of $\\Lambda_c(2940)^+$: $J^P=1/2^\\pm$, $3/2^\\pm$ and $5/2^\\pm$, the total cross section of $p\\bar{p}\\to \\bar{\\Lambda}_c \\Lambda_c(2940)^+$ is estimated, which may exceed 1 nb. With the designed luminosity ($2\\times10^{-32}$cm$^{-2}$/s) of PANDA, our estimate indicates that ten thousand events per day if $\\Lambda_c(2940)^+$ is of $J^P=1/2^+$ or $10^8$ per day if it is of $J^P=5/2^+$ can be expected. Those values actually set the lower and upper limits of the $\\Lambda_c(2940)^+$ production. In addition, we present the Dalitz plot and carry out a rough background analysis of the $\\Lambda_c(2940)^+$ production in the $p\\bar{p}\\to D^0 p\\bar{\\Lambda}_c$ and $p\\bar{p}\\to \\Sigma_c^{0,++}\\pi^{+,-}\\bar{\\Lambda}_c$ processes, which would provide valuable information for accurate determination of the $\\Lambda_c(2940)^+$ identity.

  11. Lambda-matrices and vibrating systems

    CERN Document Server

    Lancaster, Peter; Stark, M; Kahane, J P

    1966-01-01

    Lambda-Matrices and Vibrating Systems presents aspects and solutions to problems concerned with linear vibrating systems with a finite degrees of freedom and the theory of matrices. The book discusses some parts of the theory of matrices that will account for the solutions of the problems. The text starts with an outline of matrix theory, and some theorems are proved. The Jordan canonical form is also applied to understand the structure of square matrices. Classical theorems are discussed further by applying the Jordan canonical form, the Rayleigh quotient, and simple matrix pencils with late

  12. A Study of Bbar to Xi_c Lambda_c^- and Bbar to Lambda_c^+ Lambda_c^- Kbar Decays at \\babar

    Energy Technology Data Exchange (ETDEWEB)

    Aubert, B.

    2007-11-07

    We report measurements of B-meson decays into two- and three-body final states containing two charmed baryons using a sample of 230 million {Upsilon}(4S) {yields} B{bar B} decays. We find significant signals in two modes, measuring branching fractions {beta}(B{sup -} {yields} {Lambda}{sub c}{sup +}{Lambda}{sub c}{sup -}K{sup -}) = (1.14 {+-} 0.15 {+-} 0.17 {+-} 0.60) x 10{sup -3} and {beta}(B{sup -}{yields} {Xi}{sup 0}{sub c}{bar {Lambda}}{sub c}{sup -}) x {beta}({Xi}{sup 0}{sub c} {yields} {Xi}{sup -}{pi}{sup +}) = (2.08 {+-} 0.65 {+-} 0.29 {+-} 0.54) x 10{sup -5}, where the uncertainties are statistical, systematic, and from the branching fraction {beta}({Lambda}{sup +}{sub c} {yields} pK{sup -}{pi}{sup +}), respectively. We also set upper limits at the 90% confidence level on two other modes: {beta}({bar {beta}}{sup 0} {yields} {Xi}{sup +}{sub c}{bar {Lambda}}{sup -}{sub c}) x {beta}({Xi}{sup +}{sub c} {yields} {Xi}{sup -}{pi}{sup +}{pi}{sup +}) < 5.6 x 10{sup -5} and {beta}({bar B}{sup 0} {yields} {Lambda}{sup +}{sub c}{bar {Lambda}}{sup -}{sub c}{bar K}{sup 0}) < 1.5 x 10{sup -3}. We observe structure centered at an invariant mass of 2.93 GeV/c{sup 2} in the {Lambda}{sup +}{sub c}K{sup -} mass distribution of the decay B{sup -} {yields} {Lambda}{sup +}{sub c}{bar {Lambda}}{sup -}{sub c}K{sup -}.

  13. Predictions for the $\\Lambda_b \\to J/\\psi ~ \\Lambda(1405)$ decay

    CERN Document Server

    Roca, Luis; Oset, Eulogio; Meißner, Ulf-G

    2015-01-01

    We calculate the shape of the $\\pi\\Sigma$ and $\\bar K N$ invariant mass distributions in the $\\Lambda_b \\to J/\\psi\\, \\pi\\Sigma$ and $\\Lambda_b \\to J/\\psi \\,\\bar K N$ decays that are dominated by the $\\Lambda(1405)$ resonance. The weak interaction part is the same for both processes and the hadronization into the different meson-baryon channels in the final state is related by SU(3) symmetry. The most important feature is the implementation of the meson-baryon final-state interaction using two chiral unitary models from different theoretical groups. Both approaches give a good description of antikaon-nucleon scattering data, the complex energy shift in kaonic hydrogen and the line shapes of $\\pi \\Sigma K$ in photoproduction, based on the two-pole scenario for the $\\Lambda (1405)$. We find that this reaction reflects more the higher mass pole and we make predictions of the line shapes and relative strength of the meson-baryon distributions in the final state.

  14. Quark mass dependence of H-dibaryon in $\\Lambda\\Lambda$ scattering

    CERN Document Server

    Yamaguchi, Yasuhiro

    2016-01-01

    We study the quark mass dependence of the H-dibaryon in the strangeness $S=-2$ baryon-baryon scattering. A low-energy effective field theory is used to describe the coupled-channel scattering, in which the quark mass dependence is incorporated so as to reproduce the lattice QCD data in the SU(3) limit. We point out the existence of the Castillejo-Dalitz-Dyson (CDD) pole in the $\\Lambda\\Lambda$ scattering amplitude below the threshold in the SU(3) limit, which may cause the Ramsauer-Townsend effect near the $N\\Xi$ threshold at the physical point. The H-dibaryon is unbound at the physical point, and a resonance appears just below the $N\\Xi$ threshold. As a consequence of the coupled-channel dynamics, the pole associated with the resonance is not continuously connected to the bound state in the SU(3) limit. Through the extrapolation in quark masses, we show that the unitary limit of the $\\Lambda\\Lambda$ scattering is achieved between the physical point and the SU(3) limit. We discuss the possible realization of ...

  15. The radiative capture reaction rate from $\\Lambda \\Lambda$ to H dibaryon in the imaginary time method

    CERN Document Server

    Hikota, E; Hiyama, E; Oka, M

    2015-01-01

    Radiative capture rates of thermal $\\Lambda\\Lambda + \\Xi$N states into H dibaryon are calculated in the novel imaginary time method. The H dibaryon is assumed to be a bound state of $\\Xi $N with spin $J^{\\pi}= 0^+$, isospin $I=0$ and strangeness $-2$. We consider $E1$ transition to H from $\\Xi$N $(L=1)$ scattering states which mix with $\\Lambda\\Lambda (L=1)$. In order to calculate the transition rates, we formulate a coupled-channel imaginary time method by extending the one-channel formula originally proposed by Yabana and Funaki. The imaginary time method allows us to avoid the sum over all the excited thermal initial states, and thus to save computational time significantly. The transition rates are given as a function of temperature and the unknown binding energy of the H dibaryon, which we take as a parameter. It is found that the transition rate is not sensitive to the choices of the H binding energy or the strengths of the channel coupling for temperatures 3 MeV or higher.

  16. Spin and parity measurement of the Lambda(1405) baryon

    CERN Document Server

    Moriya, Kei

    2014-01-01

    A determination of the spin and parity of the $\\Lambda(1405)$ is presented using photoproduction data from the CLAS detector at Jefferson Lab. The reaction $\\gamma + p \\to K^+ + \\Lambda(1405)$ is analyzed in the decay channel $\\Lambda(1405) \\to \\Sigma^+ + \\pi^-$, where the decay distribution to $\\Sigma^+ \\pi^-$ and the variation of the $\\Sigma^+$ polarization with respect to the $\\Lambda(1405)$ polarization direction determines the parity. The $\\Lambda(1405)$ is produced, in the energy range $2.55 < W < 2.85$ GeV and for $0.6 < \\cos \\theta_{K^+} < 0.9$, with polarization $P = 0.45 \\pm 0.02 (\\text{stat}) \\pm 0.07 (\\text{syst})$. The analysis shows that the decays are in $S$ wave, with the $\\Sigma^+$ polarized such that the $\\Lambda(1405)$ has spin-parity $J^P = 1/2^-$, as expected by most theories.

  17. Dependence on the cross section of {Lambda} and anti-{Lambda} strange baryons production with the mass number; Dependencia da secao de choque de producao dos barions estranhos {Lambda} e anti-{Lambda} com o numero de massa

    Energy Technology Data Exchange (ETDEWEB)

    Gandelman, Miriam Mendes

    1992-07-01

    In this work the A dependence of the {lambda} and {lambda}{sup -} production cross sections is studied using the E769 data for the 250 GeV/c{pi}{sup -} beam interacting on Be, Cu, Al and W targets. The measured mean value of {alpha} in the region - 0.2 < x{sub f} < 0.3 and p{sub t} < 2 GeV/c is 1.03 {+-} 0.02 for the {lambda} baryon and 1.01 {+-} 0.02 for the {lambda}{sup -}. No difference is measured between the values of {alpha} for {lambda} and {lambda}{sup -}: {alpha} is a global decreasing function of x{sub f} and has no significant variation with p{sub t}. (author). 31 refs, 48 figs, 16 tabs.

  18. A stochastic model for bacteriophage therapies

    CERN Document Server

    Bardina, Xavier; Rovira, Carles; Tindel, Samy

    2011-01-01

    In this article, we analyze a system modeling bacteriophage treatments for infections in a noisy context. In the small noise regime, we show that after a reasonable amount of time the system is close to a sane equilibrium (which is a relevant biologic information) with high probability. Mathematically speaking, our study hinges on concentration techniques for delayed stochastic differential equations.

  19. Bacteriophages as surface and ground water tracers

    Directory of Open Access Journals (Sweden)

    P. Rossi

    1998-01-01

    Full Text Available Bacteriophages are increasingly used as tracers for quantitative analysis in both hydrology and hydrogeology. The biological particles are neither toxic nor pathogenic for other living organisms as they penetrate only a specific bacterial host. They have many advantages over classical fluorescent tracers and offer the additional possibility of multi-point injection for tracer tests. Several years of research make them suitable for quantitative transport analysis and flow boundary delineation in both surface and ground waters, including karst, fractured and porous media aquifers. This article presents the effective application of bacteriophages based on their use in differing Swiss hydrological environments and compares their behaviour to conventional coloured dye or salt-type tracers. In surface water and karst aquifers, bacteriophages travel at about the same speed as the typically referenced fluorescent tracers (uranine, sulphurhodamine G extra. In aquifers of interstitial porosity, however, they appear to migrate more rapidly than fluorescent tracers, albeit with a significant reduction in their numbers within the porous media. This faster travel time implies that a modified rationale is needed for defining some ground water protection area boundaries. Further developments of other bacteriophages and their documentation as tracer methods should result in an accurate and efficient tracer tool that will be a proven alternative to conventional fluorescent dyes.

  20. ADSORPTION OF BACTERIOPHAGES ON CLAY MINERALS

    Science.gov (United States)

    Theability to predict the fate of microorganisms in soil is dependent on an understanding of the process of their sorption on soil and subsurface materials. Presently, we have focused on studying the thermodynamics of sorption of bacteriophages (T-2, MS-2, and

  1. Bacteriophages as surface and ground water tracers

    Science.gov (United States)

    Rossi, P.; Dörfliger, N.; Kennedy, K.; Müller, I.; Aragno, M.

    Bacteriophages are increasingly used as tracers for quantitative analysis in both hydrology and hydrogeology. The biological particles are neither toxic nor pathogenic for other living organisms as they penetrate only a specific bacterial host. They have many advantages over classical fluorescent tracers and offer the additional possibility of multi-point injection for tracer tests. Several years of research make them suitable for quantitative transport analysis and flow boundary delineation in both surface and ground waters, including karst, fractured and porous media aquifers. This article presents the effective application of bacteriophages based on their use in differing Swiss hydrological environments and compares their behaviour to conventional coloured dye or salt-type tracers. In surface water and karst aquifers, bacteriophages travel at about the same speed as the typically referenced fluorescent tracers (uranine, sulphurhodamine G extra). In aquifers of interstitial porosity, however, they appear to migrate more rapidly than fluorescent tracers, albeit with a significant reduction in their numbers within the porous media. This faster travel time implies that a modified rationale is needed for defining some ground water protection area boundaries. Further developments of other bacteriophages and their documentation as tracer methods should result in an accurate and efficient tracer tool that will be a proven alternative to conventional fluorescent dyes.

  2. An Undergraduate Laboratory Activity Demonstrating Bacteriophage Specificity

    Directory of Open Access Journals (Sweden)

    Mary E. Allen

    2013-02-01

    Full Text Available Bacteriophage are among the most diverse and numerous microbes inhabiting our planet. Yet many laboratory activities fail to engage students in meaningful exploration of their diversity, unique characteristics, and abundance. In this curriculum activity students use a standard plaque assay to enumerate bacteriophage particles from a natural sample and use the scientific method to address questions about host specificity and diversity. A raw primary sewage sample is enriched for bacteriophage using hosts in the family Enterobacteriaceae. Students hypothesize about host specificity and use quantitative data (serial dilution and plaque assay to test their hypotheses. Combined class data also help them answer questions about phage diversity. The exercise was field tested with a class of 47 students using pre- and posttests. For all learning outcomes posttest scores were higher than pretest scores at or below p = 0.01. Average individualized learning gain (G was also calculated for each learning outcome. Students’ use of scientific language in reference to bacteriophage and host interaction significantly improved (p = 0.002; G = 0.50. Improved means of expression helped students construct better hypotheses on phage host specificity (G = 0.31, p = 0.01 and to explain the plaque assay method (G = 0.33, p = 0.002. At the end of the exercise students also demonstrated improved knowledge and understanding of phage specificity as related to phage therapy in humans (p < 0.001; G = 51.

  3. Switching the polarity of a bacteriophage integration system.

    Science.gov (United States)

    Smith, Matthew C A; Till, Rob; Smith, Margaret C M

    2004-03-01

    During lysogenic growth many temperate bacteriophage genomes are integrated into the host's chromosome and efficient integration and excision are therefore an essential part of the phage life cycle. The Streptomyces phage phiC31 encodes an integrase related to the resolvase/invertases and is evolutionarily and mechanistically distinct from the integrase of phage lambda. We show that during phiC31 integration the polarity of the recombination sites, attB and attP, is dependent on the sequences of the two base pairs (bp) where crossover occurs. A loss or switch in polarity of the recombination sites can occur by mutation of this dinucleotide, leading to incorrectly joined products. The properties of the mutant sites implies that phiC31 integrase interacts symmetrically with the substrates, which during synapsis can align apparently freely in either of two alternative forms that lead to correct or incorrect joining of products. Analysis of the topologies of the reaction products provided evidence that integrase can synapse and activate strand exchange even when recombinant products cannot form due to mismatches at the crossover site. The topologies of the recombination products are complex and indicative of multiple pathways to product formation. The efficiency of integration of a phiC31 derivative, KC859, into an attB site with switched polarity was assayed in vivo and shown to be no different from integration into a wild-type attB. Thus neither the host nor KC859 express a factor that influences the alignment of the recombination sites at synapsis.

  4. A new recipe for $\\Lambda$CDM

    CERN Document Server

    Sahni, Varun

    2015-01-01

    It is well known that a canonical scalar field is able to describe either dark matter or dark energy but not both. We demonstrate that a non-canonical scalar field can describe both dark matter and dark energy within a unified setting. We consider the simplest extension of the canonical Lagrangian ${\\cal L} \\propto X^\\alpha - \\Lambda$ with $\\alpha \\geq 1$. In this case the kinetic term in the Lagrangian behaves just like a perfect fluid, whereas the potential term is the cosmological constant. For very large values, $\\alpha \\gg 1$, the equation of state of the kinetic term drops to zero and the expansion rate of the universe mimicks $\\Lambda$CDM. The velocity of sound in this model, and the associated gravitational clustering, is sensitive to the value of $\\alpha$. For very large values of $\\alpha$ the clustering properties of our model resemble those of cold dark matter (CDM). But for smaller values of $\\alpha$, gravitational clustering on small scales is suppressed, and our model has properties resembling t...

  5. Roles of scalar mesons in charmless $\\Lambda_b$ decays

    CERN Document Server

    Hsiao, Y K; Yu, Yao; Geng, C Q

    2016-01-01

    We first study the charmless two-body $\\Lambda_b$ decays with the scalar mesons as the final states and predict that ${\\cal B}(\\Lambda_b\\to \\Lambda f_0(980,1500))=(2.9\\pm 0.7,12.4\\pm 3.8)\\times 10^{-6}$ and ${\\cal B}(\\Lambda_b\\to p K^{*-}_0(800,1430))=(1.9\\pm 0.5,14.1\\pm 4.5)\\times 10^{-6}$. With the resonant $f_0(980,1500)\\to (\\pi^+\\pi^-,K^+K^-)$ and $K^{*-}_0\\to \\bar K^0 \\pi^-$ decays, we then obtain ${\\cal B}(\\Lambda_b\\to \\Lambda (\\pi^+\\pi^-,K^+K^-))=(4.2\\pm 1.0,3.5\\pm0.7)\\times 10^{-6}$ and ${\\cal B}(\\Lambda_b\\to p\\bar K^0 \\pi^-)=(10.4\\pm2.9)\\times 10^{-6}$, in comparison with the data of $(4.6\\pm 1.9,15.9\\pm2.6)\\times 10^{-6}$ and $(12.6\\pm 4.0)\\times 10^{-6}$ from LHCb, respectively. Our results for $\\Lambda_b\\to \\Lambda\\pi^+\\pi^-$ and $\\Lambda_b\\to p\\bar K^0 \\pi^-$ would be regarded as the first evidences of the scalar meson productions in the anti-triplet $b$-baryon decays. The smaller predicted value of ${\\cal B}(\\Lambda_b\\to \\Lambda K^+K^-)$ indicates the existences of other resonant contributions t...

  6. Extending the Lambda Calculus to Express Randomized and Quantumized Algorithms

    OpenAIRE

    Maymin, Philip

    1996-01-01

    This paper introduces a formal metalanguage called the lambda-q calculus for the specification of quantum programming languages. This metalanguage is an extension of the lambda calculus, which provides a formal setting for the specification of classical programming languages. As an intermediary step, we introduce a formal metalanguage called the lambda-p calculus for the specification of programming languages that allow true random number generation. We demonstrate how selected randomized alg...

  7. Lambda-proton correlations in relativistic heavy ion collisions

    OpenAIRE

    Wang, Fuqiang; Pratt, Scott

    1999-01-01

    The prospect of using lambda-proton correlations to extract source sizes in relativistic heavy ion collisions is investigated. It is found that the strong interaction induces a large peak in the correlation function that provides more sensitive source size measurements than two-proton correlations under some circumstances. The prospect of using lambda-proton correlations to measure the time lag between lambda and proton emissions is also studied.

  8. Characterization of some pneumococcal bacteriophages

    Energy Technology Data Exchange (ETDEWEB)

    Porter, R.D.; Guild, W.R.

    1976-08-01

    The growth of pneumococcal phages at high cell and phage densities is enhanced strongly by the substitution of potassium for sodium in the medium. Initial titers of 2 x 10/sup 10/ to 4 x 10/sup 10/ PFU/ml are readily obtained, and concentrated stocks are stable in a storage buffer described here. The mechanism of the cation effect is obscure. Phages ..omega..3 and ..omega..8 each have linear double-stranded DNA of 33 x 10/sup 6/ daltons per particle, with an apparent guanine plus cytosine content of 47 to 49 mol%, as determined by buoyancy and melting temperature, but with an unusual absorbance spectrum. Efficiency of plating is high if sufficient time is allowed for a relatively slow adsorption, which differs severalfold in rate between the two phages. Morphologically, these and other pneumococcal phages are similar to coliphage lambda but with a longer tail and tail fiber. Upon UV inactivation, ..omega..3 and ..omega..8 have D/sub 37/ values of 33 and 55 J/m/sup 2/, respectively, and each shows multiplicity reactivation. A total of 13 ts mutants have been isolated from the two phages, representing only two complementation groups; complementation and recombination occur between ..omega..3 and ..omega..8 mutants. Both phages provoke high-titer antisera with extensive cross-reactivity against a number of newly isolated pneumococcal phages.

  9. STUDIES ON THE PURIFICATION OF BACTERIOPHAGE.

    Science.gov (United States)

    Kalmanson, G; Bronfenbrenner, J

    1939-11-20

    A simple method of concentrating and purifying bacteriophage has been described. The procedure consisted essentially in collecting the active agent on a reinforced collodion membrane of a porosity that would just retain all the active agent and permit extraneous material to pass through. Advantage was taken of the fact that B. coli will proliferate and regenerate bacteriophage in a completely diffusible synthetic medium with ammonia as the only source of nitrogen, which permitted the purification of the bacteriophage by copious washing. The material thus obtained was concentrated by suction and after thorough washing possessed all the activity of the original filtrate. It was labile, losing its activity in a few days on standing, and was quickly and completely inactivated upon drying. This material contained approximately 15 per cent of nitrogen and with 2 or 3 mg. samples of inactive dry residue it was possible to obtain positive protein color tests. The concentrated and purified bacteriophage has about 10(-14) mg. of nitrogen, or 6 x 10(-17) gm. of protein per unit of lytic activity. Assuming that each unit of activity represents a molecule, the calculated maximum average molecular weight would be approximately 36,000,000, and on the assumption of a spherical shape of particles and a density of 1.3, the calculated radius would be about 22 millimicra. By measurement of the diffusion rate, the average radius of particle of the fraction of the purified bacteriophage which diffuses most readily through a porous plate was found to be of the order of magnitude of 9 millimicra, or of a calculated molecular weight of 2,250,000. Furthermore, when this purified bacteriophage was fractionated by forcing it through a thin collodion membrane, which permits the passage of only the smaller particles, it was possible to demonstrate in the ultrafiltrate active particles of about 2 millimicra in radius, and of a calculated molecular weight of 25,000. It was of interest to apply

  10. Phage lambda CIII: a protease inhibitor regulating the lysis-lysogeny decision.

    Directory of Open Access Journals (Sweden)

    Oren Kobiler

    Full Text Available The ATP-dependent protease FtsH (HflB complexed with HflKC participates in post-translational control of the lysis-lysogeny decision of bacteriophage lambda by rapid degradation of lambda CII. Both phage-encoded proteins, the CII transcription activator and the CIII polypeptide, are required for efficient lysogenic response. The conserved CIII is both an inhibitor and substrate of FtsH. Here we show that the protease inhibitor CIII is present as oligomeric amphipathic alpha helical structures and functions as a competitive inhibitor of FtsH by preventing binding of the CII substrate. We identified single alanine substitutions in CIII that abolish its activity. We characterize a dominant negative effect of a CIII mutant. Thus, we suggest that CIII oligomrization is required for its function. Real-time analysis of CII activity demonstrates that the effect of CIII is not seen in the absence of either FtsH or HflKC. When CIII is provided ectopically, CII activity increases linearly as a function of the multiplicity of infection, suggesting that CIII enhances CII stability and the lysogenic response. FtsH function is essential for cellular viability as it regulates the balance in the synthesis of phospholipids and lipopolysaccharides. Genetic experiments confirmed that the CIII bacteriostatic effects are due to inhibition of FtsH. Thus, the early presence of CIII following infection stimulates the lysogenic response, while its degradation at later times ensures the reactivation of FtsH allowing the growth of the established lysogenic cell.

  11. Anisotropic Cosmological Model with Variable G and Lambda

    CERN Document Server

    Tripathy, S K; Routray, T R

    2015-01-01

    Anisotropic Bianchi-III cosmological model is investigated with variable gravitational and cosmological constants in the framework of Einstein's general relativity. The shear scalar is considered to be proportional to the expansion scalar. The dynamics of the anisotropic universe with variable G and Lambda are discussed. Without assuming any specific forms for Lambda and the metric potentials, we have tried to extract the time variation of G and Lambda from the anisotropic model. The extracted G and Lambda are in conformity with the present day observation. Basing upon the observational limits, the behaviour and range of the effective equation of state parameter are discussed.

  12. Labelled Lambda-calculi with Explicit Copy and Erase

    Directory of Open Access Journals (Sweden)

    Maribel Fernández

    2010-03-01

    Full Text Available We present two rewriting systems that define labelled explicit substitution lambda-calculi. Our work is motivated by the close correspondence between Levy's labelled lambda-calculus and paths in proof-nets, which played an important role in the understanding of the Geometry of Interaction. The structure of the labels in Levy's labelled lambda-calculus relates to the multiplicative information of paths; the novelty of our work is that we design labelled explicit substitution calculi that also keep track of exponential information present in call-by-value and call-by-name translations of the lambda-calculus into linear logic proof-nets.

  13. Global analysis of host response to induction of a latent bacteriophage

    Directory of Open Access Journals (Sweden)

    Keasling Jay D

    2007-08-01

    Full Text Available Abstract Background The transition from viral latency to lytic growth involves complex interactions among host and viral factors, and the extent to which host physiology is buffered from the virus during induction of lysis is not known. A reasonable hypothesis is that the virus should be evolutionarily selected to ensure host health throughout induction to minimize its chance of reproductive failure. To address this question, we collected transcriptional profiles of Escherichia coli and bacteriophage lambda throughout lysogenic induction by UV light. Results We observed a temporally coordinated program of phage gene expression, with distinct early, middle and late transcriptional classes. Our study confirmed known host-phage interactions of induction of the heat shock regulon, escape replication, and suppression of genes involved in cell division and initiation of replication. We identified 728 E. coli genes responsive to prophage induction, which included pleiotropic stress response pathways, the Arc and Cpx regulons, and global regulators crp and lrp. Several hundred genes involved in central metabolism, energy metabolism, translation and transport were down-regulated late in induction. Though statistically significant, most of the changes in these genes were mild, with only 140 genes showing greater than two-fold change. Conclusion Overall, we observe that prophage induction has a surprisingly low impact on host physiology. This study provides the first global dynamic picture of how host processes respond to lambda phage induction.

  14. Production of $^{6}_{\\Lambda}$H and $^{7}_{\\Lambda}$H with the (K$^{-}_{stop}$,$\\pi^+$) reaction

    CERN Document Server

    Agnello, M; Benussi, L; Bertani, M; Bhang, H C; Bianco, S; Bonomi, G; Botta, E; Bregant, M; Bressani, Tullio; Bufalino, S; Busso, L; Calvo, D; Camerini, P; Cerello, P; D'Erasmo, G; Dalena, B; Elia, D; Fabbri, F L; Faso, D; Feliciello, A; Filippi, A; Filippini, V; Fini, R A; Fiore, E M; Fujioka, H; Gianotti, P; Grion, N; Lenti, V; Lucherini, V; Manzari, V; Marcello, S; Maruta, T; Mirfakharai, N; Mori, F D; Morra, O; Nagae, T; Outa, H; Pace, E; Pallotta, M; Palomba, M; Pantaleo, A; Panzarasa, A; Paticchio, V; Piano, S; Pompili, F; Rui, R; Santo, D D; Simonetti, G; Tereshchenko, V V; Tomassini, S; Toyoda, A; Wheadon, R; Zenoni, A; perov, A K

    2006-01-01

    The production of neutron rich $\\Lambda$-hypernuclei via the ($K^-_stop$,$\\pi^+$) reaction has been studied using data collected with the FINUDA spectrometer at the DA$\\Phi$NE $\\phi$-factory (LNF). The analysis of the inclusive $\\pi^+$ momentum spectra is presented and an upper limit for the production of $^6_\\Lambda$H and $^7_\\Lambda$H from $^6$Li and $^7$Li, is assessed for the first time.

  15. Studies of $\\gamma\\gamma\\to\\Lambda\\bar{\\Lambda},\\Sigma^0\\bar{\\Sigma^0}$ production at Belle

    CERN Document Server

    Kuo, C C; Adachi, I; Aihara, H; Anipko, D; Aoki, K; Arakawa, T; Arinstein, K; Asano, Y; Aso, T; Aulchenko, V M; Aushev, T; Aziz, T; Bahinipati, S; Bakich, A M; Balagura, V; Ban, Y; Banerjee, S; Barberio, E; Barbero, M; Bay, A; Bedny, I; Belous, K S; Bitenc, U; Bizjak, I; Blyth, S; Bondar, A; Bozek, A; Bracko, M; Brodzicka, J; Browder, T E; Chang, M C; Chang, P; Chao, Y; Chen, A; Chen, K F; Chen, W T; Cheon, B G; Chistov, R; Choi, J H; Choi, S K; Choi, Y; Choi, Y K; Chuvikov, A; Cole, S; Dalseno, J; Danilov, M; Dash, M; Dowd, R; Dragic, J; Drutskoy, A; Eidelman, S; Enari, Y; Epifanov, D A; Fratina, S; Fujii, H; Fujikawa, M; Gabyshev, N; Garmash, A; Gershon, T; Go, A; Gokhroo, G; Goldenzweig, P; Golob, B; Gorisek, A; Grosse-Perdekamp, M; Guler, H; Ha, H; Haba, J; Hara, K; Hara, T; Hasegawa, Y; Hastings, N C; Hayasaka, K; Hayashii, H; Hazumi, M; Heffernan, D; Higuchi, T; Hinz, L; Hokuue, T; Hoshi, Y; Hoshina, K; Hou, S; Hou, W S; Hsiung, Y B; Igarashi, Y; Iijima, T; Ikado, K; Imoto, A; Inami, K; Ishikawa, A; Ishino, H; Itoh, K; Itoh, R; Iwabuchi, M; Iwasaki, M; Iwasaki, Y; Jacoby, C; Jones, M; Kakuno, H; Kang, J H; Kang, J S; Kapusta, P; Kataoka, S U; Katayama, N; Kawai, H; Kawasaki, T; Khan, H R; Kibayashi, A; Kichimi, H; Kikuchi, N; Kim, H J; Kim, H O; Kim, J H; Kim, S K; Kim, T H; Kim, Y J; Kinoshita, K; Kishimoto, N; Korpar, S; Kozakai, Y; Krizan, P; Krokovnyi, P P; Kubota, T; Kulasiri, R; Kumar, R; Kuo, C C; Kurihara, E; Kusaka, A; Kuzmin, A; Kwon, Y J; Lange, J S; Leder, G; Lee, J; Lee, S E; Lee, Y J; Lesiak, T; Li, J; Limosani, A; Lin, C Y; Lin, S W; Liu, Y; Liventsev, D; MacNaughton, J; Majumder, G; Mandl, F; Marlow, D; Matsumoto, T; Matyja, A; McOnie, S; Medvedeva, T; Mikami, Y; Mitaroff, W A; Miyabayashi, K; Miyake, H; Miyata, H; Miyazaki, Y; Mizuk, R; Mohapatra, D; Moloney, G R; Mori, T; Müller, J; Murakami, A; Nagamine, T; Nagasaka, Y; Nakagawa, T; Nakahama, Y; Nakamura, I; Nakano, E; Nakao, M; Nakazawa, H; Natkaniec, Z; Neichi, K; Nishida, S; Nishimura, K; Nitoh, O; Noguchi, S; Nozaki, T; Ogawa, A; Ogawa, S; Ohshima, T; Okabe, T; Okuno, S; Olsen, S L; Ono, S; Ostrowicz, W; Ozaki, H; Pakhlov, P; Pakhlova, G; Palka, H; Park, C W; Park, H; Park, K S; Parslow, N; Peak, L S; Pernicka, M; Pestotnik, R; Peters, M; Piilonen, L E; Poluektov, A; Ronga, F J; Root, N; Rorie, J; Rózanska, M; Sahoo, H; Saitoh, S; Sakai, Y; Sakamoto, H; Sakaue, H; Sarangi, T R; Sato, N; Satoyama, N; Sayeed, K; Schietinger, T; Schneider, O; Schonmeier, P; Schümann, J; Schwanda, C; Schwartz, A J; Seidl, R; Seki, T; Senyo, K; Sevior, M E; Shapkin, M; Shen, Y T; Shibuya, H; Shwartz, B; Sidorov, V; Singh, J B; Sokolov, A; Somov, A; Soni, N; Stamen, R; Stanic, S; Staric, M; Stöck, H; Sugiyama, A; Sumisawa, K; Sumiyoshi, T; Suzuki, S; Suzuki, S Y; Tajima, O; Takada, N; Takasaki, F; Tamai, K; Tamura, N; Tanabe, K; Tanaka, M; Taylor, G N; Teramoto, Y; Tian, X C; Tikhomirov, I; Trabelsi, K; Tsai, Y T; Tse, Y F; Tsuboyama, T; Tsukamoto, T; Uchida, K; Uchida, Y; Uehara, S; Uglov, T; Ueno, K; Unno, Y; Uno, S; Urquijo, P; Ushiroda, Y; Usov, Yu; Varner, G; Varvell, K E; Villa, S; Wang, C C; Wang, C H; Wang, M Z; Watanabe, M; Watanabe, Y; Wicht, J; Widhalm, L; Wiechczynski, J; Won, E; Wu, C H; Xie, Q L; Yabsley, B D; Yamaguchi, A; Yamamoto, H; Yamamoto, S; Yamashita, Y; Yamauchi, M; Heyoung Yang; Yoshino, S; Yuan, Y; Yusa, Y; Zang, S L; Zhang, C C; Zhang, J; Zhang, L M; Zhang, Z P; Zhilich, V; Ziegler, T; Zupanc, A; Zürcher, D; al., et

    2006-01-01

    Cross sections for hyperon pair production from two-photon collisions, $\\gamma\\gamma\\to\\Lambda\\bar{\\Lambda},\\Sigma^0\\bar{\\Sigma^0}$, are measured in the 2-4 GeV energy region at Belle, using 464 fb$^{-1}$ of data. A contribution from the intermediate resonance $\\eta_c(1S)$ is observed, and the products of the two-photon width of the $\\eta_c(1S)$ and its branching ratios to $\\Lambda\\bar{\\Lambda}$ and $\\Sigma^0\\bar{\\Sigma^0}$ are measured. The results will help test QCD models.

  16. The $\\Lambda\\Lambda$ Correlation Function in Au+Au collisions at $\\sqrt{s_{NN}}=$ 200 GeV

    OpenAIRE

    STAR Collaboration

    2014-01-01

    We present $\\Lambda\\Lambda$ correlation measurements in heavy-ion collisions for Au+Au collisions at $\\sqrt{s_{NN}}= 200$ GeV using the STAR experiment at the Relativistic Heavy-Ion Collider (RHIC). The Lednick\\'{y}-Lyuboshitz analytical model has been used to fit the data to obtain a source size, a scattering length and an effective range. Implications of the measurement of the $\\Lambda\\Lambda$ correlation function and interaction parameters for di-hyperon searches are discussed.

  17. Lambda Lambda Correlation Function in Au+Au Collisions at sqrt{s_NN}= 200 GeV

    OpenAIRE

    STAR Collaboration; Adamczyi, L.; Schmitz, N.; Seyboth, P.; et al

    2015-01-01

    We present \\\\Lambda\\\\Lambda$ correlation measurements in heavy-ion collisions for Au+Au collisions at sqrt{s_NN}= 200 GeV using the STAR experiment at the Relativistic Heavy-Ion Collider (RHIC). The Lednicky-Lyuboshitz analytical model has been used to fit the data to obtain a source size, a scattering length and an effective range. Implications of the measurement of the \\\\Lambda\\\\Lambda correlation function and interaction parameters for di-hyperon searches are discussed.

  18. The weak decay of lambda hypernuclei

    International Nuclear Information System (INIS)

    Experimental technique and results from a study of the weak decay modes of /sub Λ/5He are presented. The weak decay modes of lambda hypernuclei include the mesonic decays (Λ/→ p + π- and Λ → n + π0) and the nonmesonic decay modes (Λ + p → n + p and Λ + n → n + n) the /sub Λ/5He hypernuclei were produced with the K- + 6Li → π- +/sub Λ 6Li π- + Λ/6Li reaction followed by the strong decay /sub Λ/6Li → /sub Λ/5He + p. The incoming K- momentum was 800 MeV/c and the K-π angle was 100. The experiment was performed on the Low Energy Separated Beam (LESBI) at the Brookhaven National Laboratory AGS. The protons from the nonmesonic decay branch and the negative pion from the mesonic decay branch were detected in a 14 element scintillator range spectrometer. The neutrons from the nonmesonic decay branch were detected in an 18 element time-of-flight neutron detector array. The partial rates for all four of the decay modes are measured in this experiment. The total decay rate is also measured. The result for the total decay rate is 1.03 +- 0.08 in units of the free lambda decay rate. The results are compared to several calculations of /sub Λ/5He nonmesonic weak decay rates. The results are also compared to /sub Λ/12C weak decay rates previously measured by the CMU-BNL-Houston-New Mexico-Vassar collaboration. 57 refs., 98 figs., 26 tabs

  19. Protein-protein interactions in a higher-order structure direct lambda site-specific recombination.

    Science.gov (United States)

    Thompson, J F; de Vargas, L M; Skinner, S E; Landy, A

    1987-06-01

    The highly directional site-specific recombination of bacteriophage lambda is tightly regulated by the binding of three different proteins to a complex array of sites. The manner in which these reactions are both stimulated and inhibited by co-operative binding of proteins to specific sites on the P arm of attP and AttR has been elucidated by correlation of nuclease protection with recombination studies of both wild-type and mutant DNAs. In addition to co-operative forces, there is a specific competitive interaction that allows the protein-DNA complex to serve as a "biological switch". This switch does not depend upon the simple occlusion of DNA binding sites by neighboring proteins; but, rather, the outcome of this competition is dependent on long-range interactions that vary between the higher-order structures of attP and attR. These higher-order structures are dependent on cooperative interactions involving three proteins binding to five or more sites. PMID:2958633

  20. Evolution and the complexity of bacteriophages

    Directory of Open Access Journals (Sweden)

    Serwer Philip

    2007-03-01

    Full Text Available Abstract Background The genomes of both long-genome (> 200 Kb bacteriophages and long-genome eukaryotic viruses have cellular gene homologs whose selective advantage is not explained. These homologs add genomic and possibly biochemical complexity. Understanding their significance requires a definition of complexity that is more biochemically oriented than past empirically based definitions. Hypothesis Initially, I propose two biochemistry-oriented definitions of complexity: either decreased randomness or increased encoded information that does not serve immediate needs. Then, I make the assumption that these two definitions are equivalent. This assumption and recent data lead to the following four-part hypothesis that explains the presence of cellular gene homologs in long bacteriophage genomes and also provides a pathway for complexity increases in prokaryotic cells: (1 Prokaryotes underwent evolutionary increases in biochemical complexity after the eukaryote/prokaryote splits. (2 Some of the complexity increases occurred via multi-step, weak selection that was both protected from strong selection and accelerated by embedding evolving cellular genes in the genomes of bacteriophages and, presumably, also archaeal viruses (first tier selection. (3 The mechanisms for retaining cellular genes in viral genomes evolved under additional, longer-term selection that was stronger (second tier selection. (4 The second tier selection was based on increased access by prokaryotic cells to improved biochemical systems. This access was achieved when DNA transfer moved to prokaryotic cells both the more evolved genes and their more competitive and complex biochemical systems. Testing the hypothesis I propose testing this hypothesis by controlled evolution in microbial communities to (1 determine the effects of deleting individual cellular gene homologs on the growth and evolution of long genome bacteriophages and hosts, (2 find the environmental conditions that

  1. Observation of the $\\Lambda_b^0\\to\\Lambda\\phi$ decay

    CERN Document Server

    Aaij, Roel; Adeva, Bernardo; Adinolfi, Marco; Ajaltouni, Ziad; Akar, Simon; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio Augusto; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; An, Liupan; Anderlini, Lucio; Andreassi, Guido; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Aquines Gutierrez, Osvaldo; Archilli, Flavio; d'Argent, Philippe; Artamonov, Alexander; Artuso, Marina; Aslanides, Elie; Auriemma, Giulio; Baalouch, Marouen; Bachmann, Sebastian; Back, John; Badalov, Alexey; Baesso, Clarissa; Baker, Sophie; Baldini, Wander; Barlow, Roger; Barschel, Colin; Barsuk, Sergey; Barter, William; Batozskaya, Varvara; Battista, Vincenzo; Bay, Aurelio; Beaucourt, Leo; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Bel, Lennaert; Bellee, Violaine; Belloli, Nicoletta; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Benton, Jack; Berezhnoy, Alexander; Bernet, Roland; Bertolin, Alessandro; Betti, Federico; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bifani, Simone; Billoir, Pierre; Bird, Thomas; Birnkraut, Alex; Bizzeti, Andrea; Blake, Thomas; Blanc, Frédéric; Blouw, Johan; Blusk, Steven; Bocci, Valerio; Bondar, Alexander; Bondar, Nikolay; Bonivento, Walter; Borgheresi, Alessio; Borghi, Silvia; Borisyak, Maxim; Borsato, Martino; Boubdir, Meriem; Bowcock, Themistocles; Bowen, Espen Eie; Bozzi, Concezio; Braun, Svende; Britsch, Markward; Britton, Thomas; Brodzicka, Jolanta; Buchanan, Emma; Burr, Christopher; Bursche, Albert; Buytaert, Jan; Cadeddu, Sandro; Calabrese, Roberto; Calvi, Marta; Calvo Gomez, Miriam; Campana, Pierluigi; Campora Perez, Daniel; Capriotti, Lorenzo; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carniti, Paolo; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casse, Gianluigi; Cassina, Lorenzo; Castillo Garcia, Lucia; Cattaneo, Marco; Cauet, Christophe; Cavallero, Giovanni; Cenci, Riccardo; Charles, Matthew; Charpentier, Philippe; Chatzikonstantinidis, Georgios; Chefdeville, Maximilien; Chen, Shanzhen; Cheung, Shu-Faye; Chrzaszcz, Marcin; Cid Vidal, Xabier; Ciezarek, Gregory; Clarke, Peter; Clemencic, Marco; Cliff, Harry; Closier, Joel; Coco, Victor; Cogan, Julien; Cogneras, Eric; Cogoni, Violetta; Cojocariu, Lucian; Collazuol, Gianmaria; Collins, Paula; Comerma-Montells, Albert; Contu, Andrea; Cook, Andrew; Coombes, Matthew; Coquereau, Samuel; Corti, Gloria; Corvo, Marco; Couturier, Benjamin; Cowan, Greig; Craik, Daniel Charles; Crocombe, Andrew; Cruz Torres, Melissa Maria; Cunliffe, Samuel; Currie, Robert; D'Ambrosio, Carmelo; Dall'Occo, Elena; Dalseno, Jeremy; David, Pieter; Davis, Adam; De Aguiar Francisco, Oscar; De Bruyn, Kristof; De Capua, Stefano; De Cian, Michel; De Miranda, Jussara; De Paula, Leandro; De Simone, Patrizia; Dean, Cameron Thomas; Decamp, Daniel; Deckenhoff, Mirko; Del Buono, Luigi; Déléage, Nicolas; Demmer, Moritz; Derkach, Denis; Deschamps, Olivier; Dettori, Francesco; Dey, Biplab; Di Canto, Angelo; Di Ruscio, Francesco; Dijkstra, Hans; Dordei, Francesca; Dorigo, Mirco; Dosil Suárez, Alvaro; Dovbnya, Anatoliy; Dreimanis, Karlis; Dufour, Laurent; Dujany, Giulio; Dungs, Kevin; Durante, Paolo; Dzhelyadin, Rustem; Dziurda, Agnieszka; Dzyuba, Alexey; Easo, Sajan; Egede, Ulrik; Egorychev, Victor; Eidelman, Semen; Eisenhardt, Stephan; Eitschberger, Ulrich; Ekelhof, Robert; Eklund, Lars; El Rifai, Ibrahim; Elsasser, Christian; Ely, Scott; Esen, Sevda; Evans, Hannah Mary; Evans, Timothy; Falabella, Antonio; Färber, Christian; Farley, Nathanael; Farry, Stephen; Fay, Robert; Fazzini, Davide; Ferguson, Dianne; Fernandez Albor, Victor; Ferrari, Fabio; Ferreira Rodrigues, Fernando; Ferro-Luzzi, Massimiliano; Filippov, Sergey; Fiore, Marco; Fiorini, Massimiliano; Firlej, Miroslaw; Fitzpatrick, Conor; Fiutowski, Tomasz; Fleuret, Frederic; Fohl, Klaus; Fontana, Marianna; Fontanelli, Flavio; Forshaw, Dean Charles; Forty, Roger; Frank, Markus; Frei, Christoph; Frosini, Maddalena; Fu, Jinlin; Furfaro, Emiliano; Gallas Torreira, Abraham; Galli, Domenico; Gallorini, Stefano; Gambetta, Silvia; Gandelman, Miriam; Gandini, Paolo; Gao, Yuanning; García Pardiñas, Julián; Garra Tico, Jordi; Garrido, Lluis; Garsed, Philip John; Gascon, David; Gaspar, Clara; Gavardi, Laura; Gazzoni, Giulio; Gerick, David; Gersabeck, Evelina; Gersabeck, Marco; Gershon, Timothy; Ghez, Philippe; Gianì, Sebastiana; Gibson, Valerie; Girard, Olivier Göran; Giubega, Lavinia-Helena; Gligorov, Vladimir; Göbel, Carla; Golubkov, Dmitry; Golutvin, Andrey; Gomes, Alvaro; Gotti, Claudio; Grabalosa Gándara, Marc; Graciani Diaz, Ricardo; Granado Cardoso, Luis Alberto; Graugés, Eugeni; Graverini, Elena; Graziani, Giacomo; Grecu, Alexandru; Griffith, Peter; Grillo, Lucia; Grünberg, Oliver; Gui, Bin; Gushchin, Evgeny; Guz, Yury; Gys, Thierry; Hadavizadeh, Thomas; Hadjivasiliou, Christos; Haefeli, Guido; Haen, Christophe; Haines, Susan; Hall, Samuel; Hamilton, Brian; Han, Xiaoxue; Hansmann-Menzemer, Stephanie; Harnew, Neville; Harnew, Samuel; Harrison, Jonathan; He, Jibo; Head, Timothy; Heister, Arno; Hennessy, Karol; Henrard, Pierre; Henry, Louis; Hernando Morata, Jose Angel; van Herwijnen, Eric; Heß, Miriam; Hicheur, Adlène; Hill, Donal; Hoballah, Mostafa; Hombach, Christoph; Hongming, Li; Hulsbergen, Wouter; Humair, Thibaud; Hushchyn, Mikhail; Hussain, Nazim; Hutchcroft, David; Idzik, Marek; Ilten, Philip; Jacobsson, Richard; Jaeger, Andreas; Jalocha, Pawel; Jans, Eddy; Jawahery, Abolhassan; John, Malcolm; Johnson, Daniel; Jones, Christopher; Joram, Christian; Jost, Beat; Jurik, Nathan; Kandybei, Sergii; Kanso, Walaa; Karacson, Matthias; Karbach, Moritz; Karodia, Sarah; Kecke, Matthieu; Kelsey, Matthew; Kenyon, Ian; Kenzie, Matthew; Ketel, Tjeerd; Khairullin, Egor; Khanji, Basem; Khurewathanakul, Chitsanu; Kirn, Thomas; Klaver, Suzanne; Klimaszewski, Konrad; Kolpin, Michael; Komarov, Ilya; Koopman, Rose; Koppenburg, Patrick; Kozeiha, Mohamad; Kravchuk, Leonid; Kreplin, Katharina; Kreps, Michal; Krokovny, Pavel; Kruse, Florian; Krzemien, Wojciech; Kucewicz, Wojciech; Kucharczyk, Marcin; Kudryavtsev, Vasily; Kuonen, Axel Kevin; Kurek, Krzysztof; Kvaratskheliya, Tengiz; Lacarrere, Daniel; Lafferty, George; Lai, Adriano; Lambert, Dean; Lanfranchi, Gaia; Langenbruch, Christoph; Langhans, Benedikt; Latham, Thomas; Lazzeroni, Cristina; Le Gac, Renaud; van Leerdam, Jeroen; Lees, Jean-Pierre; Lefèvre, Regis; Leflat, Alexander; Lefrançois, Jacques; Lemos Cid, Edgar; Leroy, Olivier; Lesiak, Tadeusz; Leverington, Blake; Li, Yiming; Likhomanenko, Tatiana; Lindner, Rolf; Linn, Christian; Lionetto, Federica; Liu, Bo; Liu, Xuesong; Loh, David; Longstaff, Iain; Lopes, Jose; Lucchesi, Donatella; Lucio Martinez, Miriam; Luo, Haofei; Lupato, Anna; Luppi, Eleonora; Lupton, Oliver; Lusardi, Nicola; Lusiani, Alberto; Lyu, Xiao-Rui; Machefert, Frederic; Maciuc, Florin; Maev, Oleg; Maguire, Kevin; Malde, Sneha; Malinin, Alexander; Manca, Giulia; Mancinelli, Giampiero; Manning, Peter Michael; Mapelli, Alessandro; Maratas, Jan; Marchand, Jean François; Marconi, Umberto; Marin Benito, Carla; Marino, Pietro; Marks, Jörg; Martellotti, Giuseppe; Martin, Morgan; Martinelli, Maurizio; Martinez Santos, Diego; Martinez Vidal, Fernando; Martins Tostes, Danielle; Massacrier, Laure Marie; Massafferri, André; Matev, Rosen; Mathad, Abhijit; Mathe, Zoltan; Matteuzzi, Clara; Mauri, Andrea; Maurin, Brice; Mazurov, Alexander; McCann, Michael; McCarthy, James; McNab, Andrew; McNulty, Ronan; Meadows, Brian; Meier, Frank; Meissner, Marco; Melnychuk, Dmytro; Merk, Marcel; Merli, Andrea; Michielin, Emanuele; Milanes, Diego Alejandro; Minard, Marie-Noelle; Mitzel, Dominik Stefan; Molina Rodriguez, Josue; Monroy, Igancio Alberto; Monteil, Stephane; Morandin, Mauro; Morawski, Piotr; Mordà, Alessandro; Morello, Michael Joseph; Moron, Jakub; Morris, Adam Benjamin; Mountain, Raymond; Muheim, Franz; Müller, Dominik; Müller, Janine; Müller, Katharina; Müller, Vanessa; Mussini, Manuel; Muster, Bastien; Naik, Paras; Nakada, Tatsuya; Nandakumar, Raja; Nandi, Anita; Nasteva, Irina; Needham, Matthew; Neri, Nicola; Neubert, Sebastian; Neufeld, Niko; Neuner, Max; Nguyen, Anh Duc; Nguyen-Mau, Chung; Niess, Valentin; Nieswand, Simon; Niet, Ramon; Nikitin, Nikolay; Nikodem, Thomas; Novoselov, Alexey; O'Hanlon, Daniel Patrick; Oblakowska-Mucha, Agnieszka; Obraztsov, Vladimir; Ogilvy, Stephen; Okhrimenko, Oleksandr; Oldeman, Rudolf; Onderwater, Gerco; Osorio Rodrigues, Bruno; Otalora Goicochea, Juan Martin; Otto, Adam; Owen, Patrick; Oyanguren, Maria Aranzazu; Palano, Antimo; Palombo, Fernando; Palutan, Matteo; Panman, Jacob; Papanestis, Antonios; Pappagallo, Marco; Pappalardo, Luciano; Pappenheimer, Cheryl; Parker, William; Parkes, Christopher; Passaleva, Giovanni; Patel, Girish; Patel, Mitesh; Patrignani, Claudia; Pearce, Alex; Pellegrino, Antonio; Penso, Gianni; Pepe Altarelli, Monica; Perazzini, Stefano; Perret, Pascal; Pescatore, Luca; Petridis, Konstantinos; Petrolini, Alessandro; Petruzzo, Marco; Picatoste Olloqui, Eduardo; Pietrzyk, Boleslaw; Pikies, Malgorzata; Pinci, Davide; Pistone, Alessandro; Piucci, Alessio; Playfer, Stephen; Plo Casasus, Maximo; Poikela, Tuomas; Polci, Francesco; Poluektov, Anton; Polyakov, Ivan; Polycarpo, Erica; Popov, Alexander; Popov, Dmitry; Popovici, Bogdan; Potterat, Cédric; Price, Eugenia; Price, Joseph David; Prisciandaro, Jessica; Pritchard, Adrian; Prouve, Claire; Pugatch, Valery; Puig Navarro, Albert; Punzi, Giovanni; Qian, Wenbin; Quagliani, Renato; Rachwal, Bartolomiej; Rademacker, Jonas; Rama, Matteo; Ramos Pernas, Miguel; Rangel, Murilo; Raniuk, Iurii; Raven, Gerhard; Redi, Federico; Reichert, Stefanie; dos Reis, Alberto; Renaudin, Victor; Ricciardi, Stefania; Richards, Sophie; Rihl, Mariana; Rinnert, Kurt; Rives Molina, Vincente; Robbe, Patrick; Rodrigues, Ana Barbara; Rodrigues, Eduardo; Rodriguez Lopez, Jairo Alexis; Rodriguez Perez, Pablo; Rogozhnikov, Alexey; Roiser, Stefan; Romanovsky, Vladimir; Romero Vidal, Antonio; Ronayne, John William; Rotondo, Marcello; Ruf, Thomas; Ruiz Valls, Pablo; Saborido Silva, Juan Jose; Sagidova, Naylya; Saitta, Biagio; Salustino Guimaraes, Valdir; Sanchez Mayordomo, Carlos; Sanmartin Sedes, Brais; Santacesaria, Roberta; Santamarina Rios, Cibran; Santimaria, Marco; Santovetti, Emanuele; Sarti, Alessio; Satriano, Celestina; Satta, Alessia; Saunders, Daniel Martin; Savrina, Darya; Schael, Stefan; Schiller, Manuel; Schindler, Heinrich; Schlupp, Maximilian; Schmelling, Michael; Schmelzer, Timon; Schmidt, Burkhard; Schneider, Olivier; Schopper, Andreas; Schubiger, Maxime; Schune, Marie Helene; Schwemmer, Rainer; Sciascia, Barbara; Sciubba, Adalberto; Semennikov, Alexander; Sergi, Antonino; Serra, Nicola; Serrano, Justine; Sestini, Lorenzo; Seyfert, Paul; Shapkin, Mikhail; Shapoval, Illya; Shcheglov, Yury; Shears, Tara; Shekhtman, Lev; Shevchenko, Vladimir; Shires, Alexander; Siddi, Benedetto Gianluca; Silva Coutinho, Rafael; Silva de Oliveira, Luiz Gustavo; Simi, Gabriele; Sirendi, Marek; Skidmore, Nicola; Skwarnicki, Tomasz; Smith, Eluned; Smith, Iwan Thomas; Smith, Jackson; Smith, Mark; Snoek, Hella; Sokoloff, Michael; Soler, Paul; Soomro, Fatima; Souza, Daniel; Souza De Paula, Bruno; Spaan, Bernhard; Spradlin, Patrick; Sridharan, Srikanth; Stagni, Federico; Stahl, Marian; Stahl, Sascha; Stefkova, Slavomira; Steinkamp, Olaf; Stenyakin, Oleg; Stevenson, Scott; Stoica, Sabin; Stone, Sheldon; Storaci, Barbara; Stracka, Simone; Straticiuc, Mihai; Straumann, Ulrich; Sun, Liang; Sutcliffe, William; Swientek, Krzysztof; Swientek, Stefan; Syropoulos, Vasileios; Szczekowski, Marek; Szumlak, Tomasz; T'Jampens, Stephane; Tayduganov, Andrey; Tekampe, Tobias; Tellarini, Giulia; Teubert, Frederic; Thomas, Christopher; Thomas, Eric; van Tilburg, Jeroen; Tisserand, Vincent; Tobin, Mark; Tolk, Siim; Tomassetti, Luca; Tonelli, Diego; Topp-Joergensen, Stig; Tournefier, Edwige; Tourneur, Stephane; Trabelsi, Karim; Traill, Murdo; Tran, Minh Tâm; Tresch, Marco; Trisovic, Ana; Tsaregorodtsev, Andrei; Tsopelas, Panagiotis; Tuning, Niels; Ukleja, Artur; Ustyuzhanin, Andrey; Uwer, Ulrich; Vacca, Claudia; Vagnoni, Vincenzo; Valat, Sebastien; Valenti, Giovanni; Vallier, Alexis; Vazquez Gomez, Ricardo; Vazquez Regueiro, Pablo; Vázquez Sierra, Carlos; Vecchi, Stefania; van Veghel, Maarten; Velthuis, Jaap; Veltri, Michele; Veneziano, Giovanni; Vesterinen, Mika; Viaud, Benoit; Vieira, Daniel; Vieites Diaz, Maria; Vilasis-Cardona, Xavier; Volkov, Vladimir; Vollhardt, Achim; Voong, David; Vorobyev, Alexey; Vorobyev, Vitaly; Voß, Christian; de Vries, Jacco; Waldi, Roland; Wallace, Charlotte; Wallace, Ronan; Walsh, John; Wang, Jianchun; Ward, David; Watson, Nigel; Websdale, David; Weiden, Andreas; Whitehead, Mark; Wicht, Jean; Wilkinson, Guy; Wilkinson, Michael; Williams, Mark Richard James; Williams, Matthew; Williams, Mike; Williams, Timothy; Wilson, Fergus; Wimberley, Jack; Wishahi, Julian; Wislicki, Wojciech; Witek, Mariusz; Wormser, Guy; Wotton, Stephen; Wraight, Kenneth; Wright, Simon; Wyllie, Kenneth; Xie, Yuehong; Xu, Zhirui; Yang, Zhenwei; Yin, Hang; Yu, Jiesheng; Yuan, Xuhao; Yushchenko, Oleg; Zangoli, Maria; Zavertyaev, Mikhail; Zhang, Liming; Zhang, Yanxi; Zhelezov, Alexey; Zheng, Yangheng; Zhokhov, Anatoly; Zhong, Liang; Zhukov, Valery; Zucchelli, Stefano

    2016-01-01

    The $\\Lambda_b^0\\to\\Lambda\\phi$ decay is observed using data corresponding to an integrated luminosity of 3.0fb$^{-1}$ recorded by the LHCb experiment. The decay proceeds at leading order via a $b\\to s\\bar{s}s$ loop transition and is therefore sensitive to the possible presence of particles beyond the Standard Model. A first observation is reported with a significance of $5.9$ standard deviations. The value of the branching fraction is measured to be $(5.18\\pm1.04\\pm0.35\\,^{+0.67}_{-0.62})\\times10^{-6}$, where the first uncertainty is statistical, the second is systematic, and the third is related to external inputs. Triple-product asymmetries are measured to be consistent with zero.

  2. The identified. Lambda. Lambda. -hypernuclei and the predicted H-particle

    Energy Technology Data Exchange (ETDEWEB)

    Dalitz, R.H. (Oxford Univ. (UK). Dept. of Theoretical Physics); Davis, D.H. (University Coll., London (UK). Dept. of Physics and Astronomy); Fowler, P.H. (Bristol Univ. (UK). H.H. Wills Physics Lab.); Montwill, A. (University Coll., Dublin (Ireland). Dept. of Physics); Pniewski, J.; Zakrzewski, J.A. (Warsaw Univ. (Poland). Inst. of Experimental Physics)

    1989-11-08

    The existence of the H particle, the dihyperon predicted by Jaffe, would bring into question the existence of double hypernuclei. We review the two double hypernucleus events published in the literature. We include an independent report, hitherto unpublished, which was made on the {sub {Lambda}{Lambda}}{sup 10}Be event in 1963 and clarifies the salient features of the event; this report reaffirms its published interpretation. We have made a simple calculation of the energy spectrum for {Xi}-hyperons produced with K{sup -} beams in past emulsion experiments, with a result which accounts adequately for the paucity of reported double hypernucleus events. We outline a hybrid emulsion experiment that would locate {Xi}-hyperon interactions efficiently and could thereby greatly improve our knowledge of double hypernuclei. (author).

  3. lambda-fuzzy approximate fixed point in fuzzy metric spaces

    OpenAIRE

    H. Mazaheri; S. A. M. Mohsenalhosseini

    2014-01-01

    In this paper $\\lambda$-fuzzy approximate fixed point for a map and $\\lambda$-fuzzy pair approximate fixed points for two maps in fuzzy metric spaces are defined. Instead of fuzzy numbers or real numbers are used to define fuzzy points. We also prove the existence theorems.

  4. Lambda production in the DIS target fragmentation region

    CERN Document Server

    Ceccopieri, Federico Alberto

    2015-01-01

    By using a recently obtained set of Lambda fracture functions, we present predictions for Lambda production in the target fragmentation region of Semi-Inclusive Deep Inelastic Scattering in CLAS@12 GeV kinematics. We discuss a number of observables sensitive to some of the assumptions adopted in the model and which could further constrain it.

  5. Extracting $p\\Lambda$ scattering lengths from heavy ion collisions

    CERN Document Server

    Shapoval, V M; Lednicky, R; Sinyukov, Yu M

    2015-01-01

    The $p-\\Lambda \\oplus \\bar{p}-\\bar{\\Lambda}$ and $\\bar{p}-\\Lambda \\oplus p-\\bar{\\Lambda}$ correlation functions for 10% most central Au+Au collisions at top RHIC energy $\\sqrt{s_{NN}}=200$ GeV are modeled with Lednicky and Lyuboshitz analytical formula using the source radii extracted from the hydrokinetic model (HKM) simulations. For the baryon-antibaryon case the corresponding spin-averaged strong interaction scattering length is obtained by fitting the STAR correlation function. In contrast to the experimental results, where extracted $p\\bar{\\Lambda}$ source radius value was found $\\sim 2$ times smaller than the corresponding $p\\Lambda$ one, the calculations in HKM show both $p\\Lambda$ and $p\\bar{\\Lambda}$ effective source radii to be quite close, as expected from theoretical considerations. To obtain the satisfactory fit to the measured baryon-antibaryon correlation function at this large source radius value, the modified analytical approximation to the correlation function, effectively accounting for the...

  6. Transverse Lambda polarization in semi-inclusive deep inelastic scattering

    NARCIS (Netherlands)

    Anselmino, M; Boer, D; D'Alesio, U; Murgia, F

    2002-01-01

    Following a previous description of Lambda and (&ULambda;) over bar polarization in unpolarized p-p interactions, within a perturbative QCD factorization scheme with new polarizing fragmentation functions, here we investigate the transverse polarization of Lambda's and (&ULambda;) over bar 's produc

  7. A Precision Measurement of the Lambda_c Baryon Mass

    Energy Technology Data Exchange (ETDEWEB)

    Aubert, B.; Barate, R.; Boutigny, D.; Couderc, F.; Karyotakis, Y.; Lees, J.P.; Poireau, V.; Tisserand, V.; Zghiche, A.; /Annecy, LAPP; Grauges, E.; /Barcelona, IFAE; Palano, A.; Pappagallo, M.; Pompili, A.; /Bari U. /INFN, Bari; Chen, J.C.; Qi, N.D.; Rong, G.; Wang, P.; Zhu, Y.S.; /Beijing, Inst. High Energy Phys.; Eigen, G.; Ofte, I.; Stugu, B.

    2005-07-06

    The {Lambda}{sub c}{sup +} baryon mass is measured using {Lambda}{sub c}{sup +} {yields} {Lambda}K{sub S}{sup 0}K{sup +} and {Lambda}{sub c}{sup +} {yields} {Sigma}{sup 0}K{sub S}{sup 0}K{sup +} decays reconstructed in 232 fb{sup -1} of data collected with the BABAR detector at the PEP-II asymmetric-energy e{sup +}e{sup -} storage ring. The {Lambda}{sub c}{sup +} mass is measured to be 2286.46 {+-} 0.14 MeV/c{sup 2}. The dominant systematic uncertainties arise from the amount of material in the tracking volume and from the magnetic field strength.

  8. High Resolution Spectroscopy of 16N_Lambda by Electroproduction

    Energy Technology Data Exchange (ETDEWEB)

    Cusanno, Francesco; Urciuoli, Guido; Acha Quimper, Armando; Ambrozewicz, Pawel; Aniol, Konrad; Baturin, Pavlo; Bertin, Pierre; Benaoum, Hachemi; Blomqvist, Ingvar; Boeglin, Werner; Breuer, Herbert; Brindza, Paul; Bydzovsky, Petr; Camsonne, Alexandre; Chang, C.; Chang, C.C.; Chang, C.; Chang, C.C.; Chang, C.; Chang, C.C.; Chang, C.; Chang, C.C.; Chen, Jian-Ping; Choi, Seonho; Chudakov, Eugene; Cisbani, Evaristo; Colilli, Stefano; Coman, Luminita; Craver, Brandon; de Cataldo, Giacinto; De Jager, Cornelis; De Leo, Raffaele; Deur, Alexandre; Ferdi, Catherine; Feuerbach, Robert; Folts, Edward; Frullani, Salvatore; Garibaldi, Franco; Gayou, Olivier; Giuliani, Fausto; Gomez, Javier; Gricia, Massimo; Hansen, Jens-Ole; Hayes, David; Higinbotham, Douglas; Holmstrom, Timothy; Hyde, Charles; Ibrahim, Hassan; Iodice, Mauro; Jiang, Xiaodong; Kaufman, Lisa; Kino, Kouichi; Kross, Brian; Lagamba, Luigi; LeRose, John; Lindgren, Richard; Lucentini, Maurizio; Margaziotis, Demetrius; Markowitz, Pete; Marrone, Stefano; Meziani, Zein-Eddine; McCormick, Kathy; Michaels, Robert; Millener, D.; Miyoshi, Toshinobu; Moffit, Bryan; Monaghan, Peter; Moteabbed, Maryam; Munoz Camacho, Carlos; Nanda, Sirish; Nappi, E.; Nelyubin, Vladimir; Norum, Blaine; Okasyasu, Y.; Paschke, Kent; Perdrisat, Charles; Piasetzky, Eliazer; Punjabi, Vina; Qiang, Yi; Raue, Brian; Reimer, Paul; Reinhold, Joerg; Reitz, Bodo; Roche, Rikki; Rodriguez, Victor; Saha, Arunava; Santavenere, Fabio; Sarty, Adam; Segal, John; Shahinyan, Albert; Singh, Jaideep; Sirca, Simon; Snyder, Ryan; Solvignon, Patricia; Sotona, M.; Sotona, Miloslav; Sotona, M.; Sotona, Miloslav; Sotona, M.; Sotona, Miloslav; Sotona, M.; Sotona, Miloslav; Subedi, Ramesh; Sulkosky, Vince; Sulkosky, Vincent; Sulkosky, Vince; Sulkosky, Vincent; Suzuki, Tomokazu; Ueno, Hiroaki; Ulmer, Paul; Veneroni, P.P.; Voutier, Eric; Wojtsekhowski, Bogdan; Zeng, X.; Zorn, Carl

    2009-01-01

    An experimental study of the 16O(e, e'K+)16N_Lambda reaction has been performed at Jefferson Lab. A thin film of falling water was used as a target. This permitted a simultaneous measurement of the p(e, e'K+)Lambda,Sigma_0 exclusive reactions and a precise calibration of the energy scale. A ground-state binding energy of 13.76 ± 0.16 MeV was obtained for 16N_Lambda with better precision than previous measurements on the mirror hypernucleus 16O_Lambda. Precise energies have been determined for peaks arising from a Lambda in s and p orbits coupled to the p1/2 and p3/2 hole states of the 15N core nucleus.

  9. High Resolution Spectroscopy of 16N_Lambda by Electroproduction

    CERN Document Server

    Cusanno, F; Acha, A; Ambrozewicz, P; Aniol, K A; Baturin, P; Bertin, P Y; Benaoum, H; Blomqvist, K I; Böglin, W; Breuer, H; Brindza, P; Bydzovsky, P; Camsonne, A; Chang, C C; Chen, J -P; Choi, Seonho; Chudakov, E A; Cisbani, E; Colilli, S; Coman, L; Craver, B J; De Cataldo, G; De Jager, C W; De Leo, R; Deur, A P; Ferdi, C; Feuerbach, R J; Folts, E; Fratoni, R; Frullani, S; Garibaldi, F; Gayou, O; Giuliani, F; Gómez, J; Gricia, M; Hansen, J O; Hayes, D; Higinbotham, D W; Holmstrom, T K; Hyde, C E; Ibrahim, H F; Iodice, M; Jiang, X; Kaufman, L J; Kino, K; Kross, B; Lagamba, L; LeRose, J J; Lindgren, R A; Lucentini, M; Margaziotis, D J; Markowitz, P; Marrone, S; Meziani, Z E; McCormick, K; Michaels, R W; Millener, D J; Miyoshi, T; Moffit, B; Monaghan, P A; Moteabbed, M; Camacho, C Munoz; Nanda, S; Nappi, E; Nelyubin, V V; Norum, B E; Okasyasu, Y; Paschke, K D; Perdrisat, C F; Piasetzky, E; Punjabi, V A; Qiang, Y; Raue, B; Reimer, P E; Reinhold, J; Reitz, B; Roche, R E; Rodriguez, V M; Saha, A; Santavenere, F; Sarty, A J; Segal, J; Shahinyan, A; Singh, J; Sirca, S; Snyder, R; Solvignon, P H; Sotona, M; Subedi, R; Sulkosky, V A; Suzuki, T; Ueno, H; Ulmer, P E; Veneroni, P; Voutier, E; Wojtsekhowski, B B; Zeng, X; Zorn, C

    2008-01-01

    An experimental study of the 16O(e,e'K^+)16N_Lambda reaction has been performed at Jefferson Lab. A thin film of falling water was used as a target. This permitted a simultaneous measurement of the p(e,e'K^+)Lambda,Sigma_0 exclusive reactions and a precise calibration of the energy scale. A ground-state binding energy of 13.76 +/- 0.16 MeV was obtained for 16N_Lambda with better precision than previous measurements on the mirror hypernucleus 16O_Lambda. Precise energies have been determined for peaks arising from a Lambda in s and p orbits coupled to the p_{1/2} and p_{3/2} hole states of the 15N core nucleus.

  10. Hadronic Effective Field Theory Applied to $\\Lambda$-Hypernuclei

    CERN Document Server

    McIntire, J

    2003-01-01

    Furnstahl, Serot, and Tang (FST) have developed a methodology for constructing an effective lagrangian for the nuclear many-body system which contains the underlying symmetries of QCD. Density Functional Theory (DFT) is used as a theoretical justification for the relativistic Hartree (Kohn-Sham) equations derived from this effective lagrangian. In the present work, this approach is extended to the region of nonzero strangeness in application to single-particle states in $\\Lambda$-hypernuclei. To include $\\Lambda$'s, an additional contribution to their effective lagrangian is systematically constructed within the framework of FST. The relativistic Hartree (Kohn-Sham) equations are solved numerically, and least-square fits to a series of experimental levels are preformed at various levels of truncation in the extended lagrangian. The ground-state properties of any $\\Lambda$-hypernuclei are then predicted. In addition, ground-state $Lambda$-particle-nucleon-hole splittings are calculated where appropriate, and t...

  11. Algebraic model for single-particle energies of $\\Lambda$ hypernuclei

    CERN Document Server

    Fortunato, L

    2016-01-01

    A model is proposed for the spectrum of $\\Lambda$ hypernuclei based on the $u(3)\\times u(2)$ Lie algebra, in which the internal degrees of freedom of the spin-1/2 $\\Lambda$ particle are treated in the Fermionic $u(2)$ scheme, while the motion of the hyperon inside a nucleus is described in the Bosonic $u(3)$ harmonic oscillator scheme. Within this model, a simple formula for single-particle energies of the $\\Lambda$ particle is obtained from the natural dynamical symmetry. The formula is applied to the experimental data on the reaction spectroscopy for the $^{89}_\\Lambda$Y and $^{51}_\\Lambda$V hypernuclei, providing a clear theoretical interpretation of the observed structures.

  12. Measurement of the production fraction times branching fraction $\\boldsymbol{ f(b\\to\\Lambda_{b})\\cdot \\mathcal{B}(\\Lambda_{b}\\to J/\\psi \\Lambda)}$

    Energy Technology Data Exchange (ETDEWEB)

    Abazov, Victor Mukhamedovich; /Dubna, JINR; Abbott, Braden Keim; /Oklahoma U.; Acharya, Bannanje Sripath; /Tata Inst.; Adams, Mark Raymond; /Illinois U., Chicago; Adams, Todd; /Florida State U.; Alexeev, Guennadi D.; /Dubna, JINR; Alkhazov, Georgiy D.; /St. Petersburg, INP; Alton, Andrew K.; /Michigan U. /Augustana Coll., Sioux Falls; Alverson, George O.; /Northeastern U.; Alves, Gilvan Augusto; /Rio de Janeiro, CBPF; Ancu, Lucian Stefan; /Nijmegen U. /Fermilab

    2011-05-01

    The {Lambda}{sub b}(udb) baryon is observed in the decay {Lambda}{sub b} {yields} J/{psi}{Lambda} using 6.1 fb{sup -1} of p{bar p} collisions collected with the D0 detector at {radical}s = 1.96 TeV. The production fraction multiplied by the branching fraction for this decay relative to that for the decay B{sup 0} {yields} J/{psi}K{sub s}{sup 0} is measured to be 0.345 {+-} 0.034 (stat.) {+-} 0.033 (syst.) {+-} 0.003 (PDG). Using the world average value of f(b {yields} B{sup 0}) {center_dot} {Beta}(B{sup 0} {yields} J/{psi}K{sub s}{sup 0}) = (1.74 {+-} 0.08) x 10{sup -5}, they obtain f(b {yields} {Lambda}{sub b}) {center_dot} {Beta}({Lambda}{sub b} {yields} J/{psi}{Lambda}) = (6.01 {+-} 0.60 (stat.) {+-} 0.58 (syst.) {+-} 0.28 (PDG)) x 10{sup -5}. This measurement represents an improvement in precision by about a factor of three with respect to the current world average.

  13. Bacteriophages and bacteriophage-derived endolysins as potential therapeutics to combat Gram-positive spore forming bacteria.

    Science.gov (United States)

    Nakonieczna, A; Cooper, C J; Gryko, R

    2015-09-01

    Since their discovery in 1915, bacteriophages have been routinely used within Eastern Europe to treat a variety of bacterial infections. Although initially ignored by the West due to the success of antibiotics, increasing levels and diversity of antibiotic resistance is driving a renaissance for bacteriophage-derived therapy, which is in part due to the highly specific nature of bacteriophages as well as their relative abundance. This review focuses on the bacteriophages and derived lysins of relevant Gram-positive spore formers within the Bacillus cereus group and Clostridium genus that could have applications within the medical, food and environmental sectors.

  14. Application of bacteriophages in sensor development.

    Science.gov (United States)

    Peltomaa, Riikka; López-Perolio, Irene; Benito-Peña, Elena; Barderas, Rodrigo; Moreno-Bondi, María Cruz

    2016-03-01

    Bacteriophage-based bioassays are a promising alternative to traditional antibody-based immunoassays. Bacteriophages, shortened to phages, can be easily conjugated or genetically engineered. Phages are robust, ubiquitous in nature, and harmless to humans. Notably, phages do not usually require inoculation and killing of animals; and thus, the production of phages is simple and economical. In recent years, phage-based biosensors have been developed featuring excellent robustness, sensitivity, and selectivity in combination with the ease of integration into transduction devices. This review provides a critical overview of phage-based bioassays and biosensors developed in the last few years using different interrogation methods such as colorimetric, enzymatic, fluorescence, surface plasmon resonance, quartz crystal microbalance, magnetoelastic, Raman, or electrochemical techniques.

  15. Detection of bacteria with bioluminescent reporter bacteriophage.

    Science.gov (United States)

    Klumpp, Jochen; Loessner, Martin J

    2014-01-01

    Bacteriophages are viruses that exclusively infect bacteria. They are ideally suited for the development of highly specific diagnostic assay systems. Bioluminescent reporter bacteriophages are designed and constructed by integration of a luciferase gene in the virus genome. Relying on the host specificity of the phage, the system enables rapid, sensitive, and specific detection of bacterial pathogens. A bioluminescent reporter phage assay is superior to any other molecular detection method, because gene expression and light emission are dependent on an active metabolism of the bacterial cell, and only viable cells will yield a signal. In this chapter we introduce the concept of creating reporter phages, discuss their advantages and disadvantages, and illustrate the advances made in developing such systems for different Gram-negative and Gram-positive pathogens. The application of bioluminescent reporter phages for the detection of foodborne pathogens is emphasized.

  16. Measurement of the differential branching fraction of the decay $\\Lambda_b^0 \\rightarrow \\Lambda\\mu^+\\mu^-$

    CERN Document Server

    Aaij, R; Adinolfi, M; Adrover, C; Affolder, A; Ajaltouni, Z; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves Jr, A A; Amato, S; Amerio, S; Amhis, Y; Anderlini, L; Anderson, J; Andreassen, R; Andrews, J E; Appleby, R B; Aquines Gutierrez, O; Archilli, F; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Baalouch, M; Bachmann, S; Back, J J; Baesso, C; Balagura, V; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Bauer, Th; Bay, A; Beddow, J; Bedeschi, F; Bediaga, I; Belogurov, S; Belous, K; Belyaev, I; Ben-Haim, E; Bencivenni, G; Benson, S; Benton, J; Berezhnoy, A; Bernet, R; Bettler, M -O; van Beuzekom, M; Bien, A; Bifani, S; Bird, T; Bizzeti, A; Bjørnstad, P M; Blake, T; Blanc, F; Blouw, J; Blusk, S; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borghi, S; Borgia, A; Bowcock, T J V; Bowen, E; Bozzi, C; Brambach, T; van den Brand, J; Bressieux, J; Brett, D; Britsch, M; Britton, T; Brook, N H; Brown, H; Burducea, I; Bursche, A; Busetto, G; Buytaert, J; Cadeddu, S; Callot, O; Calvi, M; Calvo Gomez, M; Camboni, A; Campana, P; Campora Perez, D; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carranza-Mejia, H; Carson, L; Carvalho Akiba, K; Casse, G; Castillo Garcia, L; Cattaneo, M; Cauet, Ch; Cenci, R; Charles, M; Charpentier, Ph; Chen, P; Chiapolini, N; Chrzaszcz, M; Ciba, K; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coca, C; Coco, V; Cogan, J; Cogneras, E; Collins, P; Comerma-Montells, A; Contu, A; Cook, A; Coombes, M; Coquereau, S; Corti, G; Couturier, B; Cowan, G A; Craik, D C; Cunliffe, S; Currie, R; D'Ambrosio, C; David, P; David, P N Y; Davis, A; De Bonis, I; De Bruyn, K; De Capua, S; De Cian, M; De Miranda, J M; De Paula, L; De Silva, W; De Simone, P; Decamp, D; Deckenhoff, M; Del Buono, L; Déléage, N; Derkach, D; Deschamps, O; Dettori, F; Di Canto, A; Di Ruscio, F; Dijkstra, H; Dogaru, M; Donleavy, S; Dordei, F; Dosil Suárez, A; Dossett, D; Dovbnya, A; Dupertuis, F; Durante, P; Dzhelyadin, R; Dziurda, A; Dzyuba, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; van Eijk, D; Eisenhardt, S; Eitschberger, U; Ekelhof, R; Eklund, L; El Rifai, I; Elsasser, Ch; Falabella, A; Färber, C; Fardell, G; Farinelli, C; Farry, S; Fave, V; Ferguson, D; Fernandez Albor, V; Ferreira Rodrigues, F; Ferro-Luzzi, M; Filippov, S; Fiore, M; Fitzpatrick, C; Fontana, M; Fontanelli, F; Forty, R; Francisco, O; Frank, M; Frei, C; Frosini, M; Furcas, S; Furfaro, E; Gallas Torreira, A; Galli, D; Gandelman, M; Gandini, P; Gao, Y; Garofoli, J; Garosi, P; Garra Tico, J; Garrido, L; Gaspar, C; Gauld, R; Gersabeck, E; Gersabeck, M; Gershon, T; Ghez, Ph; Gibson, V; Giubega, L; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gordon, H; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graziani, G; Grecu, A; Greening, E; Gregson, S; Griffith, P; Grünberg, O; Gui, B; Gushchin, E; Guz, Yu; Gys, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hall, S; Hamilton, B; Hampson, T; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; Hartmann, T; He, J; Head, T; Heijne, V; Hennessy, K; Henrard, P; Hernando Morata, J A; van Herwijnen, E; Hicheur, A; Hicks, E; Hill, D; Hoballah, M; Holtrop, M; Hombach, C; Hopchev, P; Hulsbergen, W; Hunt, P; Huse, T; Hussain, N; Hutchcroft, D; Hynds, D; Iakovenko, V; Idzik, M; Ilten, P; Jacobsson, R; Jaeger, A; Jans, E; Jaton, P; Jawahery, A; Jing, F; John, M; Johnson, D; Jones, C R; Joram, C; Jost, B; Kaballo, M; Kandybei, S; Kanso, W; Karacson, M; Karbach, T M; Kenyon, I R; Ketel, T; Keune, A; Khanji, B; Kochebina, O; Komarov, I; Koopman, R F; Koppenburg, P; Korolev, M; Kozlinskiy, A; Kravchuk, L; Kreplin, K; Kreps, M; Krocker, G; Krokovny, P; Kruse, F; Kucharczyk, M; Kudryavtsev, V; Kvaratskheliya, T; La Thi, V N; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lambert, R W; Lanciotti, E; Lanfranchi, G; Langenbruch, C; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J -P; Lefèvre, R; Leflat, A; Lefrançois, J; Leo, S; Leroy, O; Lesiak, T; Leverington, B; Li, Y; Li Gioi, L; Liles, M; Lindner, R; Linn, C; Liu, B; Liu, G; Lohn, S; Longstaff, I; Lopes, J H; Lopez-March, N; Lu, H; Lucchesi, D; Luisier, J; Luo, H; Machefert, F; Machikhiliyan, I V; Maciuc, F; Maev, O; Malde, S; Manca, G; Mancinelli, G; Maratas, J; Marconi, U; Marino, P; Märki, R; Marks, J; Martellotti, G; Martens, A; Martín Sánchez, A; Martinelli, M; Martinez Santos, D; Martins Tostes, D; Massafferri, A; Matev, R; Mathe, Z; Matteuzzi, C; Maurice, E; Mazurov, A; Mc Skelly, B; McCarthy, J; McNab, A; McNulty, R; Meadows, B; Meier, F; Meissner, M; Merk, M; Milanes, D A; Minard, M -N; Molina Rodriguez, J; Monteil, S; Moran, D; Morawski, P; Mordà, A; Morello, M J; Mountain, R; Mous, I; Muheim, F; Müller, K; Muresan, R; Muryn, B; Muster, B; Naik, P; Nakada, T; Nandakumar, R; Nasteva, I; Needham, M; Neubert, S; Neufeld, N; Nguyen, A D; Nguyen, T D; Nguyen-Mau, C; Nicol, M; Niess, V; Niet, R; Nikitin, N; Nikodem, T; Nomerotski, A; Novoselov, A; Oblakowska-Mucha, A; Obraztsov, V; Oggero, S; Ogilvy, S; Okhrimenko, O; Oldeman, R; Orlandea, M; Otalora Goicochea, J M; Owen, P; Oyanguren, A; Pal, B K; Palano, A; Palutan, M; Panman, J; Papanestis, A; Pappagallo, M; Parkes, C; Parkinson, C J; Passaleva, G; Patel, G D; Patel, M; Patrick, G N; Patrignani, C; Pavel-Nicorescu, C; Pazos Alvarez, A; Pellegrino, A; Penso, G; Pepe Altarelli, M; Perazzini, S; Perez Trigo, E; Pérez-Calero Yzquierdo, A; Perret, P; Perrin-Terrin, M; Pescatore, L; Pessina, G; Petridis, K; Petrolini, A; Phan, A; Picatoste Olloqui, E; Pietrzyk, B; Pilař, T; Pinci, D; Playfer, S; Plo Casasus, M; Polci, F; Polok, G; Poluektov, A; Polycarpo, E; Popov, A; Popov, D; Popovici, B; Potterat, C; Powell, A; Prisciandaro, J; Pritchard, A; Prouve, C; Pugatch, V; Puig Navarro, A; Punzi, G; Qian, W; Rademacker, J H; Rakotomiaramanana, B; Rangel, M S; Raniuk, I; Rauschmayr, N; Raven, G; Redford, S; Reid, M M; dos Reis, A C; Ricciardi, S; Richards, A; Rinnert, K; Rives Molina, V; Roa Romero, D A; Robbe, P; Roberts, D A; Rodrigues, E; Rodriguez Perez, P; Roiser, S; Romanovsky, V; Romero Vidal, A; Rouvinet, J; Ruf, T; Ruffini, F; Ruiz, H; Ruiz Valls, P; Sabatino, G; Saborido Silva, J J; Sagidova, N; Sail, P; Saitta, B; Salustino Guimaraes, V; Salzmann, C; Sanmartin Sedes, B; Sannino, M; Santacesaria, R; Santamarina Rios, C; Santovetti, E; Sapunov, M; Sarti, A; Satriano, C; Satta, A; Savrie, M; Savrina, D; Schaack, P; Schiller, M; Schindler, H; Schlupp, M; Schmelling, M; Schmidt, B; Schneider, O; Schopper, A; Schune, M -H; Schwemmer, R; Sciascia, B; Sciubba, A; Seco, M; Semennikov, A; Sepp, I; Serra, N; Serrano, J; Seyfert, P; Shapkin, M; Shapoval, I; Shatalov, P; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, O; Shevchenko, V; Shires, A; Silva Coutinho, R; Sirendi, M; Skwarnicki, T; Smith, N A; Smith, E; Smith, J; Smith, M; Sokoloff, M D; Soler, F J P; Soomro, F; Souza, D; Souza De Paula, B; Spaan, B; Sparkes, A; Spradlin, P; Stagni, F; Stahl, S; Steinkamp, O; Stoica, S; Stone, S; Storaci, B; Straticiuc, M; Straumann, U; Subbiah, V K; Sun, L; Swientek, S; Syropoulos, V; Szczekowski, M; Szczypka, P; Szumlak, T; T'Jampens, S; Teklishyn, M; Teodorescu, E; Teubert, F; Thomas, C; Thomas, E; van Tilburg, J; Tisserand, V; Tobin, M; Tolk, S; Tonelli, D; Topp-Joergensen, S; Torr, N; Tournefier, E; Tourneur, S; Tran, M T; Tresch, M; Tsaregorodtsev, A; Tsopelas, P; Tuning, N; Ubeda Garcia, M; Ukleja, A; Urner, D; Ustyuzhanin, A; Uwer, U; Vagnoni, V; Valenti, G; Vallier, A; Van Dijk, M; Vazquez Gomez, R; Vazquez Regueiro, P; Vázquez Sierra, C; Vecchi, S; Velthuis, J J; Veltri, M; Veneziano, G; Vesterinen, M; Viaud, B; Vieira, D; Vilasis-Cardona, X; Vollhardt, A; Volyanskyy, D; Voong, D; Vorobyev, A; Vorobyev, V; Voß, C; Voss, H; Waldi, R; Wallace, C; Wallace, R; Wandernoth, S; Wang, J; Ward, D R; Watson, N K; Webber, A D; Websdale, D; Whitehead, M; Wicht, J; Wiechczynski, J; Wiedner, D; Wiggers, L; Wilkinson, G; Williams, M P; Williams, M; Wilson, F F; Wimberley, J; Wishahi, J; Witek, M; Wotton, S A; Wright, S; Wu, S; Wyllie, K; Xie, Y; Xing, Z; Yang, Z; Young, R; Yuan, X; Yushchenko, O; Zangoli, M; Zavertyaev, M; Zhang, F; Zhang, L; Zhang, W C; Zhang, Y; Zhelezov, A; Zhokhov, A; Zhong, L; Zvyagin, A

    2013-01-01

    The differential branching fraction of the decay $\\Lambda_b^0\\rightarrow\\Lambda\\mu^+\\mu^-$ is measured as a function of the square of the dimuon invariant mass, $q^2$. A yield of $78\\pm12$ $\\Lambda_b^0\\rightarrow\\Lambda\\mu^+\\mu^-$ decays is observed using data, corresponding to an integrated luminosity of 1.0,fb$^{-1}$, collected by the LHCb experiment at a centre-of-mass energy of 7\\,TeV. A significant signal is found in the $q^2$ region above the square of the $J/\\psi$ mass, while at lower-$q^2$ values upper limits are set on the differential branching fraction. Integrating the differential branching fraction over $q^2$, while excluding the $J/\\psi$ and $\\psi(2S)$ regions, gives a branching fraction of $B(\\Lambda_b^0\\rightarrow\\Lambda\\mu^+\\mu^-)=(0.96\\pm 0.16(stat)\\pm 0.13(syst)\\pm 0.21 (\\mathrm{norm}))\\times 10^{-6}$, where the uncertainties are statistical, systematic and due to the normalisation mode, $\\Lambda_b^0\\rightarrow J/\\psi\\Lambda$, respectively.

  17. Bacteriophages as recognition and identification agents

    Energy Technology Data Exchange (ETDEWEB)

    Teodorescu, M.C.; Gaspar, A.

    1987-04-23

    Bacteriophages are employed as agents for recognition and identification of molecules and cellular materials, using their ability to recognize their bacterial host, by coating them with antibodies or by selecting them to perform in a manner analogous to antibodies. Visibility for identification is effected by incorporating a fluorescent agent, a radioisotope, a metal, an enzyme, or other staining material. The method of this invention may be utilized in selected clinical procedures, and is adaptable to use in an assay kit.

  18. Going viral: designing bioactive surfaces with bacteriophage.

    Science.gov (United States)

    Hosseinidoust, Zeinab; Olsson, Adam L J; Tufenkji, Nathalie

    2014-12-01

    Bacteriophage-functionalized bioactive surfaces are functional materials that can be used as antimicrobial surfaces in medical applications (e.g., indwelling medical devices or wound dressings) or as biosensors for bacterial capture and detection. Despite offering immense potential, designing efficient phage-functionalized bioactive surfaces is hampered by a number of challenges. This review offers an overview of the current state of knowledge in this field and presents a critical perspective of the technological promises and challenges.

  19. A new look at bacteriophage phylogenomics

    OpenAIRE

    Nóbrega, Franklin; Pinto, Graça; Azeredo, Joana; Kluskens, Leon

    2012-01-01

    Bacteriophages or phages are viruses that only infect bacteria. The International Committee on Taxonomy of Viruses classified these viruses in accordance with the morphology of their free virion particles and type and size of their genome. This system fails on the classification of several phages, which have their genome already sequenced. It also requires a morphological analysis by transmission electron microscopy, which is very expensive and time consuming [1]. In 2002 Rohwe...

  20. Genomic impact of CRISPR immunization against bacteriophages.

    Science.gov (United States)

    Barrangou, Rodolphe; Coûté-Monvoisin, Anne-Claire; Stahl, Buffy; Chavichvily, Isabelle; Damange, Florian; Romero, Dennis A; Boyaval, Patrick; Fremaux, Christophe; Horvath, Philippe

    2013-12-01

    CRISPR (clustered regularly interspaced short palindromic repeats) together with CAS (RISPR-associated) genes form the CRISPR-Cas immune system, which provides sequence-specific adaptive immunity against foreign genetic elements in bacteria and archaea. Immunity is acquired by the integration of short stretches of invasive DNA as novel 'spacers' into CRISPR loci. Subsequently, these immune markers are transcribed and generate small non-coding interfering RNAs that specifically guide nucleases for sequence-specific cleavage of complementary sequences. Among the four CRISPR-Cas systems present in Streptococcus thermophilus, CRISPR1 and CRISPR3 have the ability to readily acquire new spacers following bacteriophage or plasmid exposure. In order to investigate the impact of building CRISPR-encoded immunity on the host chromosome, we determined the genome sequence of a BIM (bacteriophage-insensitive mutant) derived from the DGCC7710 model organism, after four consecutive rounds of bacteriophage challenge. As expected, active CRISPR loci evolved via polarized addition of several novel spacers following exposure to bacteriophages. Although analysis of the draft genome sequence revealed a variety of SNPs (single nucleotide polymorphisms) and INDELs (insertions/deletions), most of the in silico differences were not validated by Sanger re-sequencing. In addition, two SNPs and two small INDELs were identified and tracked in the intermediate variants. Overall, building CRISPR-encoded immunity does not significantly affect the genome, which allows the maintenance of important functional properties in isogenic CRISPR mutants. This is critical for the development and formulation of sustainable and robust next-generation starter cultures with increased industrial lifespans.

  1. Isolation of Arthrobacter Bacteriophage from Soil †

    OpenAIRE

    Germida, James J.; Casida, L. E.

    1981-01-01

    Soil was percolated with water and various nutrient solutions, and then the percolates were analyzed for bacteriophages which produced plaques on various Arthrobacter strains. The water percolates did not contain detectable phage. In contrast, phages for A. globiformis strains ATCC 8010 and 4336, and for several recent Arthrobacter species soil isolates, were easily detected in nutrient broth, soil extract, and cation-complete medium percolates. These percolates did not contain phage that pro...

  2. Use of bacteriophages to control biofilms

    OpenAIRE

    Sillankorva, Sanna

    2009-01-01

    Tese de doutoramento em Engenharia Química e Biológica After several years of abandonment, the use of bacteriophages (phages) for killing bacteria has withdrawn recent attention and reappraisal. This has led to a vast phage research, in varied fields, with impressive outcomes and currently several studies are ongoing with animals, horticulture and agriculture products, and even with humans. Despite this enthusiasm, there is a lack of research conserning phage utilization to red...

  3. Genetically modified bacteriophages in applied microbiology.

    Science.gov (United States)

    Bárdy, P; Pantůček, R; Benešík, M; Doškař, J

    2016-09-01

    Bacteriophages represent a simple viral model of basic research with many possibilities for practical application. Due to their ability to infect and kill bacteria, their potential in the treatment of bacterial infection has been examined since their discovery. With advances in molecular biology and gene engineering, the phage application spectrum has been expanded to various medical and biotechnological fields. The construction of bacteriophages with an extended host range or longer viability in the mammalian bloodstream enhances their potential as an alternative to conventional antibiotic treatment. Insertion of active depolymerase genes to their genomes can enforce the biofilm disposal. They can also be engineered to transfer various compounds to the eukaryotic organisms and the bacterial culture, applicable for the vaccine, drug or gene delivery. Phage recombinant lytic enzymes can be applied as enzybiotics in medicine as well as in biotechnology for pathogen detection or programmed cell death in bacterial expression strains. Besides, modified bacteriophages with high specificity can be applied as bioprobes in detection tools to estimate the presence of pathogens in food industry, or utilized in the control of food-borne pathogens as part of the constructed phage-based biosorbents.

  4. Genetically modified bacteriophages in applied microbiology.

    Science.gov (United States)

    Bárdy, P; Pantůček, R; Benešík, M; Doškař, J

    2016-09-01

    Bacteriophages represent a simple viral model of basic research with many possibilities for practical application. Due to their ability to infect and kill bacteria, their potential in the treatment of bacterial infection has been examined since their discovery. With advances in molecular biology and gene engineering, the phage application spectrum has been expanded to various medical and biotechnological fields. The construction of bacteriophages with an extended host range or longer viability in the mammalian bloodstream enhances their potential as an alternative to conventional antibiotic treatment. Insertion of active depolymerase genes to their genomes can enforce the biofilm disposal. They can also be engineered to transfer various compounds to the eukaryotic organisms and the bacterial culture, applicable for the vaccine, drug or gene delivery. Phage recombinant lytic enzymes can be applied as enzybiotics in medicine as well as in biotechnology for pathogen detection or programmed cell death in bacterial expression strains. Besides, modified bacteriophages with high specificity can be applied as bioprobes in detection tools to estimate the presence of pathogens in food industry, or utilized in the control of food-borne pathogens as part of the constructed phage-based biosorbents. PMID:27321680

  5. Call for a dedicated European legal framework for bacteriophage therapy.

    Science.gov (United States)

    Verbeken, Gilbert; Pirnay, Jean-Paul; Lavigne, Rob; Jennes, Serge; De Vos, Daniel; Casteels, Minne; Huys, Isabelle

    2014-04-01

    The worldwide emergence of antibiotic resistances and the drying up of the antibiotic pipeline have spurred a search for alternative or complementary antibacterial therapies. Bacteriophages are bacterial viruses that have been used for almost a century to combat bacterial infections, particularly in Poland and the former Soviet Union. The antibiotic crisis has triggered a renewed clinical and agricultural interest in bacteriophages. This, combined with new scientific insights, has pushed bacteriophages to the forefront of the search for new approaches to fighting bacterial infections. But before bacteriophage therapy can be introduced into clinical practice in the European Union, several challenges must be overcome. One of these is the conceptualization and classification of bacteriophage therapy itself and the extent to which it constitutes a human medicinal product regulated under the European Human Code for Medicines (Directive 2001/83/EC). Can therapeutic products containing natural bacteriophages be categorized under the current European regulatory framework, or should this framework be adapted? Various actors in the field have discussed the need for an adapted (or entirely new) regulatory framework for the reintroduction of bacteriophage therapy in Europe. This led to the identification of several characteristics specific to natural bacteriophages that should be taken into consideration by regulators when evaluating bacteriophage therapy. One important consideration is whether bacteriophage therapy development occurs on an industrial scale or a hospital-based, patient-specific scale. More suitable regulatory standards may create opportunities to improve insights into this promising therapeutic approach. In light of this, we argue for the creation of a new, dedicated European regulatory framework for bacteriophage therapy. PMID:24500660

  6. Isolation and characterization of bacteriophages of Salmonella enterica serovar Pullorum.

    Science.gov (United States)

    Bao, H; Zhang, H; Wang, R

    2011-10-01

    In this study, 2 bacteriophages of Salmonella Pullorum were isolated using an enrichment protocol and the double agar layer method. They were named PSPu-95 and PSPu-4-116, respectively, against clinical isolates of Salmonella Pullorum SPu-95 and SPu-116. The host ranges of the 2 bacteriophages were determined by performing spot tests with 20 bacteria strains. Both bacteriophages had wide host ranges. Bacteriophage PSPu-95 had a lytic effect on 17 of the 20 isolates (85%), and PSPu-4-116 produced a lytic effect on 14 isolates (70%) and was the only bacteriophage that produced a clear plaque on enterotoxigenic Escherichia coli K88. Transmission electron microscopy revealed the bacteriophages belonged to the order Caudovirales. Bacteriophage PSPu-95 was a member of the family Siphoviridae, but bacteriophage PSPu-4-116 belonged to the family Myoviridae. Both had a double-stranded DNA, which was digested with HindIII or EcoRI, that was estimated to be 58.3 kbp (PSPu-95) and 45.2 kbp (PSPu-4-116) by 1% agar electrophoresis. One-step growth kinetics showed that the latent periods were all less than 20 min, and the burst size was 77.5 pfu/cell for PSPu-95 and 86 pfu/cell for PSPu-4-116. The bacteriophages were able to survive in a pH range between 4 and 10, and they were able to survive in a treatment of 70°C for 60 min. The characterizations of these 2 bacteriophages were helpful in establishing a basis for adopting the most effective bacteriophage to control bacteria in the poultry industry.

  7. $\\Lambda_c\\Sigma_c\\pi$ coupling and $\\Sigma_c \\rightarrow\\Lambda_c \\pi$ decay in lattice QCD

    CERN Document Server

    Can, K U; Oka, M; Takahashi, T T

    2016-01-01

    We evaluate the $\\Lambda_c\\Sigma_c\\pi$ coupling constant ($G_{\\Lambda_c \\Sigma_c \\pi}$) and the width of the strong decay $\\Sigma_c \\rightarrow\\Lambda_c \\pi$ in 2+1 flavor lattice QCD on four different ensembles with pion masses ranging from 700 MeV to 300 MeV. We find $G_{\\Lambda_c \\Sigma_c \\pi}=18.332(1.476)_{\\rm{stat.}}(2.171)_{\\rm{syst.}}$ and the decay width $\\Gamma(\\Sigma_c \\rightarrow\\Lambda_c \\pi)=1.65(28)_{\\rm{stat.}}(30)_{\\rm{syst.}}$~MeV on the physical quark-mass point, which is in agreement with the recent experimental determination.

  8. Tensor coupling effects on spin symmetry in anti-Lambda spectrum of hypernuclei

    CERN Document Server

    Song, Chunyan; Meng, Jie

    2010-01-01

    The effects of $\\bar\\Lambda\\bar\\Lambda\\omega$-tensor coupling on the spin symmetry of $\\bar{\\Lambda}$ spectra in $\\bar{\\Lambda}$-nucleus systems have been studied with the relativistic mean-field theory. Taking $^{12}$C+$\\bar{\\Lambda}$ as an example, it is found that the tensor coupling enlarges the spin-orbit splittings of $\\bar\\Lambda$ by an order of magnitude although its effects on the wave functions of $\\bar{\\Lambda}$ are negligible. Similar conclusions has been observed in $\\bar{\\Lambda}$-nucleus of different mass regions, including $^{16}$O+$\\bar{\\Lambda}$, $^{40}$Ca+$\\bar{\\Lambda}$ and $^{208}$Pb+$\\bar{\\Lambda}$. It indicates that the spin symmetry in anti-lambda-nucleus systems is still good irrespective of the tensor coupling.

  9. Bacteriophage P70: unique morphology and unrelatedness to other Listeria bacteriophages.

    Science.gov (United States)

    Schmuki, Martina M; Erne, Doris; Loessner, Martin J; Klumpp, Jochen

    2012-12-01

    Listeria monocytogenes is an important food-borne pathogen, and its bacteriophages find many uses in detection and biocontrol of its host. The novel broad-host-range virulent phage P70 has a unique morphology with an elongated capsid. Its genome sequence was determined by a hybrid sequencing strategy employing Sanger and PacBio techniques. The P70 genome contains 67,170 bp and 119 open reading frames (ORFs). Our analyses suggest that P70 represents an archetype of virus unrelated to other known Listeria bacteriophages.

  10. Measurement of the $\\Lambda_{b}^{0}$ Decay Form Factor

    CERN Document Server

    Abdallah, J; Adam, W; Adzic, P; Albrecht, T; Alderweireld, T; Alemany-Fernandez, R; Allmendinger, T; Allport, P P; Amaldi, Ugo; Amapane, N; Amato, S; Anashkin, E; Andreazza, A; Andringa, S; Anjos, N; Antilogus, P; Apel, W D; Arnoud, Y; Ask, S; Åsman, B; Augustin, J E; Augustinus, A; Baillon, Paul; Ballestrero, A; Bambade, P; Barbier, R; Bardin, Dimitri Yuri; Barker, G; Baroncelli, A; Battaglia, Marco; Baubillier, M; Becks, K H; Begalli, M; Behrmann, A; Ben-Haim, E; Benekos, N C; Benvenuti, Alberto C; Bérat, C; Berggren, M; Berntzon, L; Bertrand, D; Besançon, M; Besson, N; Bloch, D; Blom, M; Bluj, M; Bonesini, M; Boonekamp, M; Booth, P S L; Borisov, G; Botner, O; Bouquet, B; Bowcock, T J V; Boyko, I; Bracko, M; Brenner, R; Brodet, E; Brückman, P; Brunet, J M; Bugge, L; Buschmann, P; Calvi, M; Camporesi, T; Canale, V; Carena, F; Castro, N; Cavallo, F R; Chapkin, M M; Charpentier, P; Checchia, P; Chierici, R; Shlyapnikov, P; Chudoba, J; Chung, S U; Cieslik, K; Collins, P; Contri, R; Cosme, G; Cossutti, F; Costa, M J; Crawley, B; Crennell, D J; Cuevas-Maestro, J; D'Hondt, J; Dalmau, J; Da Silva, T; Da Silva, W; Della Ricca, G; De Angelis, A; de Boer, Wim; De Clercq, C; De Lotto, B; De Maria, N; De Min, A; De Paula, L S; Di Ciaccio, Lucia; Di Simone, A; Doroba, K; Drees, J; Dris, M; Eigen, G; Ekelöf, T J C; Ellert, M; Elsing, M; Espirito-Santo, M C; Fanourakis, G K; Fassouliotis, D; Feindt, M; Fernández, J; Ferrer, A; Ferro, F; Flagmeyer, U; Föth, H; Fokitis, E; Fulda-Quenzer, F; Fuster, J A; Gandelman, M; García, C; Gavillet, P; Gazis, E N; Gokieli, R; Golob, B; Gómez-Ceballos, G; Gonçalves, P; Graziani, E; Grosdidier, G; Grzelak, K; Guy, J; Haag, C; Hallgren, A; Hamacher, K; Hamilton, K; Haug, S; Hauler, F; Hedberg, V; Hennecke, M; Herr, H; Hoffman, J; Holmgren, S O; Holt, P J; Houlden, M A; Hultqvist, K; Jackson, J N; Jarlskog, G; Jarry, P; Jeans, D; Johansson, E K; Johansson, P D; Jonsson, P; Joram, C; Jungermann, L; Kapusta, F; Katsanevas, S; Katsoufis, E C; Kernel, G; Kersevan, Borut P; Kerzel, U; Kiiskinen, A P; King, B T; Kjaer, N J; Kluit, P; Kokkinias, P; Kourkoumelis, C; Kuznetsov, O; Krumshtein, Z; Kucharczyk, M; Lamsa, J; Leder, G; Ledroit, F; Leinonen, L; Leitner, R; Lemonne, J; Lepeltier, V; Lesiak, T; Liebig, W; Liko, D; Lipniacka, A; Lopes, J H; López, J M; Loukas, D; Lutz, P; Lyons, L; MacNaughton, J; Malek, A; Maltezos, S; Mandl, F; Marco, J; Marco, R; Maréchal, B; Margoni, M; Marin, J C; Mariotti, C; Markou, A; Martínez-Rivero, C; Masik, J; Mastroyiannopoulos, N; Matorras, F; Matteuzzi, C; Mazzucato, F; Mazzucato, M; McNulty, R; Meroni, C; Meyer, W T; Myagkov, A; Migliore, E; Mitaroff, W A; Mjörnmark, U; Moa, T; Moch, M; Mönig, K; Monge, R; Montenegro, J; Moraes, D; Moreno, S; Morettini, P; Müller, U; Münich, K; Mulders, M; Mundim, L M; Murray, W; Muryn, B; Myatt, Gerald; Myklebust, T; Nassiakou, M; Navarria, Francesco Luigi; Nawrocki, K; Nicolaidou, R; Nikolenko, M; Oblakowska-Mucha, A; Obraztsov, V F; Olshevskii, A G; Onofre, A; Orava, Risto; Österberg, K; Ouraou, A; Oyanguren, A; Paganoni, M; Paiano, S; Palacios, J P; Palka, H; Papadopoulou, T D; Pape, L; Parkes, C; Parodi, F; Parzefall, U; Passeri, A; Passon, O; Peralta, L; Perepelitsa, V F; Perrotta, A; Petrolini, A; Piedra, J; Pieri, L; Pierre, F; Pimenta, M; Piotto, E; Podobnik, T; Poireau, V; Pol, M E; Polok, G; Poropat, P; Pozdnyakov, V; Pukhaeva, N; Pullia, Antonio; Rames, J; Ramler, L; Read, A; Rebecchi, P; Rehn, J; Reid, D; Reinhardt, R; Renton, P B; Richard, F; Rídky, J; Rivero, M; Rodríguez, D; Romero, A; Ronchese, P; Rosenberg, E I; Roudeau, Patrick; Rovelli, T; Ruhlmann-Kleider, V; Ryabtchikov, D; Sadovskii, A; Salmi, L; Salt, J; Savoy-Navarro, A; Schwickerath, U; Segar, A; Sekulin, R L; Siebel, M; Sissakian, A N; Smadja, G; Smirnova, O G; Sokolov, A; Sopczak, A; Sosnowski, R; Spassoff, Tz; Stanitzki, M; Stocchi, A; Strauss, J; Stugu, B; Szczekowski, M; Szeptycka, M; Szumlak, T; Tabarelli de Fatis, T; Taffard, A C; Tegenfeldt, F; Timmermans, J; Tkatchev, L G; Tobin, M; Todorovova, S; Tomé, B; Tonazzo, A; Tortosa, P; Travnicek, P; Treille, D; Tristram, G; Trochimczuk, M; Troncon, C; Turluer, M L; Tyapkin, I A; Tyapkin, P; Tzamarias, S; Uvarov, V; Valenti, G; van Dam, P; Van Eldik, J; Van Lysebetten, A; Van Remortel, N; Van Vulpen, I B; Vegni, G; Veloso, F; Venus, W A; Verdier, P; Verzi, V; Vilanova, D; Vitale, L; Vrba, V; Wahlen, H; Washbrook, A J; Weiser, C; Wicke, D; Wickens, J H; Wilkinson, G; Winter, M; Witek, M; Yushchenko, O P; Zalewska-Bak, A; Zalewski, Piotr; Zavrtanik, D; Zhuravlov, V; Zimin, N I; Zinchenko, A I; Zupan, M

    2004-01-01

    The form factor of Lambda_b^0 baryons is estimated using 3.46 10^6 hadronic Z decays collected by the DELPHI experiment between 1992 and 1995. Charmed Lambda_c^+ baryons fully reconstructed in the pK-pi+, pK0_S, and Lambda pi+pi+pi- modes, are associated to a lepton with opposite charge in order to select Lambda_b^0 -> Lambda_c^+ l^- anti-nu_l decays. From a combined likelihood and event rate fit to the distribution of the Isgur-Wise variable w, and using the Heavy Quark Effective Theory (HQET), the slope of the b-baryon form factor is measured to be: rho-hat^2 = 2.03 +/- 0.46 (stat) ^{+0.72}_{-1.00} (syst). The exclusive semileptonic branching fraction Br(Lambda_b^0 -> Lambda_c^+ l^- anti-nu_l) can be derived from rho-hat^2 and is found to be (5.0^{+1.1}_{-0.8} (stat) ^{+1.6}_{-1.2} (syst))%. Limits on other branching fractions are also obtained.

  11. Mass and $K\\Lambda$ coupling of $N^*(1535)$

    CERN Document Server

    Liu, B C

    2006-01-01

    Using resonance isobar model and effective Lagrangian approach, from recent BES results on $J/\\psi\\to\\bar pp\\eta$ and $\\psi\\to\\bar pK^+\\Lambda$, we deduce the ratio between effective coupling constants of $N^*(1535)$ to $K\\Lambda$ and $p\\eta$ to be $R\\equiv g_{N^*(1535)K\\Lambda}/g_{N^*(1535)p\\eta} =1.3\\pm 0.3$. With previous known value of $g_{N^*(1535)p\\eta}$, the obtained new value of $g_{N^*(1535)K\\Lambda}$ is shown to reproduce recent $pp\\to pK^+\\Lambda$ near-threshold cross section data as well. Taking into account this large $N^*K\\Lambda$ coupling in the coupled channel Breit-Wigner formula for the $N^*(1535)$, its Berit-Wigner mass is found to be around 1400 MeV, much smaller than previous value of about 1535 MeV obtained without including its coupling to $K\\Lambda$. The implication on the nature of $N^*(1535)$ is discussed.

  12. Semileptonic Decays of Heavy Lambda Baryons in a Quark Model

    Energy Technology Data Exchange (ETDEWEB)

    Winston Roberts; Muslema Pervin; Simon Capstick

    2005-03-01

    The semileptonic decays of {Lambda}{sub c} and {Lambda}{sub b} are treated in the framework of a constituent quark model. Both nonrelativistic and semirelativistic Hamiltonians are used to obtain the baryon wave functions from a fit to the spectra, and the wave functions are expanded in both the harmonic oscillator and Sturmian bases. The latter basis leads to form factors in which the kinematic dependence on q{sup 2} is in the form of multipoles, and the resulting form factors fall faster as a function of q{sup 2} in the available kinematic ranges. As a result, decay rates obtained in the two models using the Sturmian basis are significantly smaller than those obtained using the harmonic oscillator basis. In the case of the {Lambda}{sub c}, decay rates calculated using the Sturmian basis are closer to the experimentally reported rates. However, we find a semileptonic branching fraction for the {Lambda}{sub c} to decay to excited {Lambda}* states of 11% to 19%, in contradiction with what is assumed in available experimental analyses. Our prediction for the {Lambda}{sub b} semileptonic decays is that decays to the ground state {Lambda}{sub c} provide a little less than 70% of the total semileptonic decay rate. For the decays {Lambda}{sub b} {yields} {Lambda}{sub c}, the analytic form factors we obtain satisfy the relations expected from heavy-quark effective theory at the non-recoil point, at leading and next-to-leading orders in the heavy-quark expansion. In addition, some features of the heavy-quark limit are shown to naturally persist as the mass of the heavy quark in the daughter baryon is decreased.

  13. Experience of the Eliava Institute in bacteriophage therapy

    Institute of Scientific and Technical Information of China (English)

    Mzia; Kutateladze

    2015-01-01

    <正>The rapid propagation of multidrug resistant bacterial strains is leading to renewed interest in bacteriophage therapy.With challenges in the treatment of bacterial infections,it is essential for people worldwide to understand how alternative approaches,such as bacteriophages,could be used to combat antibiotic resistant bacteria.The Eliava Institute

  14. Sequence and comparative analysis of Leuconostoc dairy bacteriophages

    DEFF Research Database (Denmark)

    Kot, Witold; Hansen, Lars Henrik; Neve, Horst;

    2014-01-01

    Bacteriophages attacking Leuconostoc species may significantly influence the quality of the final product. There is however limited knowledge of this group of phages in the literature. We have determined the complete genome sequences of nine Leuconostoc bacteriophages virulent to either Leuconostoc...

  15. Bacteriophages: The viruses for all seasons of molecular biology

    Directory of Open Access Journals (Sweden)

    Karam Jim D

    2005-03-01

    Full Text Available Abstract Bacteriophage research continues to break new ground in our understanding of the basic molecular mechanisms of gene action and biological structure. The abundance of bacteriophages in nature and the diversity of their genomes are two reasons why phage research brims with excitement. The pages of Virology Journal will reflect the excitement of the "New Phage Biology."

  16. Weak decay of P shell lambda hypernuclei

    International Nuclear Information System (INIS)

    Methods and results of an experiment to study the weak decay of Lambda hypernuclei are presented. The hypernuclei under study were 12C, 11B, plus a hypernuclear of unknown charge and mass designed /sup a/Z. The hypernuclear production data were obtained using the Hypernuclear Spectrometer and the Low Energy Separated Beam (LESB I), at the AGS of Brookhaven National Laboratory. The Kaon beam momentum was 805 MeV/c. Three hypernuclear states were observed, the 12C ground state, the P substitutional state, and the S substitutional state. The P substitutional state has been previously observed to decay to 11B plus a low energy proton. Hence, decay products observed in coincidence with this state are from the weak decay of 11B. The S substitutional state is shown to decay to a stable but unidentified hypernucleus. The protons from the nonmesonic decay branch, and the negative pion from the mesonic decay branch were detected in a 14 elements scintillator range spectrometer. The neutrons from the nonmesonic decay branches were detected in a 24 element neutron detector. The experimental results are compared with several calculations for hypernuclear nonmesonic decay in infinite nuclear matter and in finite nuclei. Several of these calculations agree favorably with the total nonmesonic rate, but none of the calculations are able to determine both the nonmesonic rate and the neutron stimulated fraction. 40 refs., 103 figs., 25 tabs

  17. Spin Symmetry for Anti-Lambda Spectrum in atomic nucleus

    CERN Document Server

    Song, Chunyan; Meng, Jie

    2009-01-01

    The spin symmetry of anti-Lambda spectrum in nucleus ^{16}O has been studied in the relativistic mean field theory. The spin-orbit splittings of spin doublets are found to be around 0.03-0.07 MeV and the dominant components of the Dirac spinor for the anti-Lambda spin doublets are found to be near identical. It indicates that there is an even better spin symmetry in the anti-Lambda spectrum than that in the anti-nucleon spectrum.

  18. Spin Symmetry for Anti-Lambda Spectrum in Atomic Nucleus

    Institute of Scientific and Technical Information of China (English)

    SONG Chun-Yan; YAO Jiang-Ming; MENG Jie

    2009-01-01

    The spin symmetry of the anti-Lambda spectrum in nucleus ~(16)O is studied in the relativistic mean field theory.The spin-orbit splittings of spin doublets are found to be around 0.03-0.07 MeV and the dominant components of the Dirac spinor for the anti-Lambda spin doublets are found to be near identical.It is indicated that there is an even better spin symmetry in the anti-Lambda spectrum than that in the anti-nucleon spectrum.

  19. Lambda Boo Abundance Patterns: Accretion from Orbiting Sources

    CERN Document Server

    Jura, M

    2015-01-01

    The abundance anomalies in lambda Boo stars are popularly explained by element-specific mass inflows at rates that are much greater than empirically-inferred bounds for interstellar accretion. Therefore, a lambda Boo star's thin outer envelope must derive from a companion star, planet, analogs to Kuiper Belt Objects or a circumstellar disk. Because radiation pressure on gas-phase ions might selectively allow the accretion of carbon, nitrogen, and oxygen and inhibit the inflow of elements such as iron, the source of the acquired matter need not contain dust. We propose that at least some lambda Boo stars accrete from the winds of hot Jupiters.

  20. El editor Lambda para matemáticas

    OpenAIRE

    Muñoz Carenas, J.; Fernández del Campo Sánchez, J. E.

    2011-01-01

    Se presentan las características y principales prestaciones del editor matemático Lambda (LAMBDA: Linear Access to Mathematics for Braille Devices and Audio-synthesis; en español, Acceso lineal a las matemáticas para dispositivos braille o de síntesis de audio), con el cual estudiantes y profesionales con discapacidad visual pueden escribir, leer y manipular expresiones simbólico-matemáticas hasta un nivel universitario superior. Lambda permite la edición accesible y la comunicación gráfica i...

  1. Effects of scalar leptoquark on semileptonic $\\Lambda_b$ decays

    CERN Document Server

    Sahoo, Suchismita

    2016-01-01

    We study the scalar leptoquark effects on the rare semileptonic decays of $\\Lambda_b$ baryon, governed by the quark level transition $b \\to s l^+ l^-$. We estimate the branching ratios, forward-backward asymmetries, lepton polarization parameters and the lepton flavour non-universality effects in these decay channels. We find significant deviations from the corresponding standard model predictions in some of the observables due to leptoquark effects. We also investigate the lepton flavour violating decays $\\Lambda_b \\to \\Lambda l_i^- l_j^+$, the branching ratios of which are found to be ${\\cal O}(10^{-10} - 10^{-9})$.

  2. Semantics of a Typed Algebraic Lambda-Calculus

    Directory of Open Access Journals (Sweden)

    Benoît Valiron

    2010-06-01

    Full Text Available Algebraic lambda-calculi have been studied in various ways, but their semantics remain mostly untouched. In this paper we propose a semantic analysis of a general simply-typed lambda-calculus endowed with a structure of vector space. We sketch the relation with two established vectorial lambda-calculi. Then we study the problems arising from the addition of a fixed point combinator and how to modify the equational theory to solve them. We sketch an algebraic vectorial PCF and its possible denotational interpretations.

  3. Semantics of a Typed Algebraic Lambda-Calculus

    OpenAIRE

    Benoît Valiron

    2010-01-01

    Algebraic lambda-calculi have been studied in various ways, but their semantics remain mostly untouched. In this paper we propose a semantic analysis of a general simply-typed lambda-calculus endowed with a structure of vector space. We sketch the relation with two established vectorial lambda-calculi. Then we study the problems arising from the addition of a fixed point combinator and how to modify the equational theory to solve them. We sketch an algebraic vectorial PCF and its possible den...

  4. POSSIBILITES OF BACTERIOPHAGES APPLICATION IN SURGERY AND TRANSPLANTATION

    Directory of Open Access Journals (Sweden)

    N.I. Gabrielyan

    2012-01-01

    Full Text Available The review of the modern data about bacteriophages and to their application to surgery is presented. Interest to bacteriophages is closely connected with an urgency of a problem of postoperative infectious complications and to resistance increase nosocomial species microbes to antibiotics. Successful demonstrative application of bacteriophages on experimental models for a reduction of is conditional-pathogenic microbes in biofilms, for treatment septicemia at the animals, caused resistance species P. aeruginosa, Klebsiella spp., Staphylococcus and other microbes is described. Positive results on application of bacteriophages in surgery are received at treatment of the infected wounds, peritonitis, infectious complications after liver and kidney transplantation. New mechanisms of action of bacteriophages, including their influence on transplantology immunity are resulted. Use of phages as alternatives of treatment and preventive maintenance of a superinfection at imunocomprometive patients is perspective. 

  5. The effects of bacteriophage and nanoparticles on microbial processes

    Science.gov (United States)

    Moody, Austin L.

    There are approximately 1031 tailed phages in the biosphere, making them the most abundant organism. Bacteriophages are viruses that infect bacteria. Due to the large diversity and abundance, no two bacteriophages that have been isolated are genetically the same. Phage products have potential in disease therapy to solve bacteria-related problems, such as infections resulting from resistant strains of Staphylococcus aureus. A bacteriophage capable of infecting methicillin-resistant S. aureus (MRSA) was isolated from bovine hair. The bacteriophage, named JB phage, was characterized using purification, amplification, cesium chloride banding, scanning electron microscopy, and transmission electron microscopy. JB phage and nanoparticles were used in various in vitro and in vivo models to test their effects on microbial processes. Scanning and transmission electron microscopy studies revealed strong interactions between JB phage and nanoparticles, which resulted in increased bacteriophage infectivity. JB phage and nanoparticle cocktails were used as a therapeutic to treat skin and systemic infections in mice caused by MRSA.

  6. [THE IDENTIFICATION AND DIFFERENTIATION OF BACTERIOPHAGES OF HUMAN PATHOGENIC VIBRIO].

    Science.gov (United States)

    Gaevskaia, N E; Kudriakova, T A; Makedonova, L D; Kachkina, G V

    2015-04-01

    The issue of identification and differentiation of large group of bacteriophages of human pathogenic vibrio is still unresolved. In research and practical applied purposes it is important to consider characteristics of bacteriophages for establishing similarity and differences between them. The actual study was carried out to analyze specimens of DNA-containing bacteriophages of pathogenic vibrio. The overwhelming majority of them characterized by complicated type of symmetry--phages with double-helical DNA and also phages with mono-helical DNA structure discovered recently in vibrio. For the first time, the general framework of identification and differentiation of bacteriophages of pathogenic vibrio was developed. This achievement increases possibility to establish species assignment of phages and to compare with phages registered in the database. "The collection of bacteriophages and test-strains of human pathogenic vibrio" (No2010620549 of 24.09.210).

  7. Perturbative Corrections to $\\Lambda_b \\to \\Lambda$ Form Factors from QCD Light-Cone Sum Rules

    CERN Document Server

    Wang, Yu-Ming

    2015-01-01

    We compute radiative corrections to $\\Lambda_b \\to \\Lambda$ from factors, at next-to-leading logarithmic accuracy, from QCD light-cone sum rules with $\\Lambda_b$-baryon distribution amplitudes. Employing the diagrammatic approach factorization of the vacuum-to-$\\Lambda_b$-baryon correlation function is justified at leading power in $\\Lambda/m_b$, with the aid of the method of regions. Hard functions entering the factorization formulae are identical to the corresponding matching coefficients of heavy-to-light currents from QCD onto soft-collinear effective theory. The universal jet function from integrating out the hard-collinear fluctuations exhibits richer structures compared with the one involved in the factorization expressions of the vacuum-to-$B$-meson correlation function. Based upon the QCD resummation improved sum rules we observe that the perturbative corrections at ${\\cal O}(\\alpha_s)$ shift the $\\Lambda_b \\to \\Lambda$ from factors at large recoil significantly and the dominant contribution originat...

  8. Observation of the Baryonic B decay B0bar to Lambda_c^+ anti-Lambda K-

    Energy Technology Data Exchange (ETDEWEB)

    Lees, J.P.; Poireau, V.; Tisserand, V.; /Annecy, LAPP; Garra Tico, J.; Grauges, E.; /Barcelona U., ECM; Martinelli, M.; /INFN, Bari /Bari U.; Milanes, D.A.; /INFN, Bari; Palano, A.; /INFN, Bari /Bari U.; Pappagallo, M.; /INFN, Bari /Bari U.; Eigen, G.; Stugu, B.; Sun, L.; /Bergen U.; Brown, D.N.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G.; /LBL, Berkeley /UC, Berkeley; Koch, H.; Schroeder, T.; /Ruhr U., Bochum; Asgeirsson, D.J.; Hearty, C.; Mattison, T.S.; /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UC, Riverside /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /Frascati /INFN, Genoa /Genoa U. /INFN, Genoa /Genoa U. /INFN, Genoa /Genoa U. /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /Indian Inst. Tech., Guwahati /Harvard U. /Harvey Mudd Coll. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa State U. /Iowa State U. /Johns Hopkins U. /Orsay, LAL /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U., Comp. Sci. Dept. /Maryland U. /Massachusetts U., Amherst /MIT /McGill U. /INFN, Milan /Milan U. /INFN, Milan /Milan U. /INFN, Milan /INFN, Milan /Milan U. /INFN, Milan /Milan U. /INFN, Milan /Milan U. /Mississippi U. /Montreal U. /INFN, Naples /Naples U. /INFN, Naples /Naples U. /INFN, Naples /Naples U. /INFN, Naples /Naples U. /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /Padua U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /INFN, Padua /INFN, Padua /Padua U. /INFN, Padua /Padua U. /Paris U., VI-VII /INFN, Perugia /Perugia U. /INFN, Perugia /Perugia U. /INFN, Perugia /Perugia U. /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa U. /Sassari U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa, Scuola Normale Superiore /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa U. /INFN, Pisa /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /INFN, Rome /Rostock U. /Rutherford /DAPNIA, Saclay /SLAC /South Carolina U. /Southern Methodist U. /Stanford U., Phys. Dept. /SUNY, Albany /Tel Aviv U. /Tennessee U. /Texas U. /Texas U., Dallas /INFN, Turin /Turin U. /INFN, Turin /Turin U. /INFN, Trieste /Trieste U. /INFN, Trieste /Trieste U. /Valencia U., IFIC /Victoria U. /Warwick U. /Wisconsin U., Madison

    2011-11-08

    The authors report the observation of the baryonic B decay {bar B}{sup 0} {yields} {Lambda}{sub c}{sup +} {bar {Lambda}}K{sup -} with a significance larger than 7 standard deviations based on 471 x 10{sup 6} B{bar B} pairs collected with the BABAR detector at the PEP-II storage ring at SLAC. They measure the branching fraction for the decay {bar B}{sup 0} {yields} {Lambda}{sub c}{sup +} {bar {Lambda}}K{sup -} to be (3.8 {+-} 0.8{sub stat} {+-} 0.2{sub sys} {+-} 1.0 {sub {Lambda}{sub c}{sup +}}) x 10{sup -5}. The uncertainties are statistical, systematic, and due to the uncertainty in the {Lambda}{sub c}{sup +} branching fraction. They find that the {Lambda}{sub c}{sup +} K{sup -} invariant mass distribution shows an enhancement above 3.5 GeV/c{sup 2}.

  9. The electromagnetic form factors of the $\\Lambda$ in the timelike region

    CERN Document Server

    Haidenbauer, J

    2016-01-01

    The reaction $e^+e^- \\to \\bar \\Lambda \\Lambda$ is investigated for energies close to the threshold. Specific emphasis is put on the role played by the interaction in the final $\\bar \\Lambda \\Lambda$ system which is taken into account rigorously. For that interaction a variety of $\\bar \\Lambda \\Lambda$ potential models is employed that have been constructed for the analysis of the reaction $\\bar p p \\to \\bar \\Lambda \\Lambda$ in the past. The enhancement of the effective form factor for energies close to the $\\bar \\Lambda \\Lambda$ threshold, seen in pertinent experiments, is reproduced. Predictions for the $\\Lambda$ electromagnetic form factors $G_M$ and $G_E$ in the timelike region and for spin-dependent observables such as spin-correlation parameters are presented.

  10. Characterisation of Strongly Normalising lambda-mu-Terms

    Directory of Open Access Journals (Sweden)

    Steffen van Bakel

    2013-07-01

    Full Text Available We provide a characterisation of strongly normalising terms of the lambda-mu-calculus by means of a type system that uses intersection and product types. The presence of the latter and a restricted use of the type omega enable us to represent the particular notion of continuation used in the literature for the definition of semantics for the lambda-mu-calculus. This makes it possible to lift the well-known characterisation property for strongly-normalising lambda-terms - that uses intersection types - to the lambda-mu-calculus. From this result an alternative proof of strong normalisation for terms typeable in Parigot's propositional logical system follows, by means of an interpretation of that system into ours.

  11. Mesonic Decay of Charm Hypernuclei $\\Lambda^+_c$

    CERN Document Server

    Ghosh, Sabyasachi; Krein, Gastão

    2016-01-01

    $\\Lambda^+_c$ hypernuclei are expected to have binding energies and other properties similar to those of strange hypernuclei in view of the similarity between the quark structures of the strange and charmed hyperons, namely $\\Lambda(uds)$ and $\\Lambda^+_c (udc)$. One striking difference however occurs in their mesonic decays, as there is almost no Pauli blocking in the nucleonic decay of a charm hypernucleus because the final-state nucleons leave the nucleus at high energies. The nuclear medium nevertheless affects the mesonic decays of charm hypernucleus because the nuclear mean fields modify the masses of the charm hyperon. In the present communication we present results of a first investigation of the effects of finite baryon density on different weak mesonic decay channels of the $\\Lambda^+_c$ baryon. We found a non-negligible reduction of the decay widths as compared to their vacuum values.

  12. First Observation of the $\\Lambda(1405)$ Line Shape in Electroproduction

    CERN Document Server

    Lu, H Y

    2013-01-01

    We report the first observation of the line shape of the $\\Lambda(1405)$ from electroproduction, and show that it is not a simple Breit-Wigner resonance. Electroproduction of $K^+ \\Lambda(1405)$ off the proton was studied by using data from CLAS at Jefferson Lab in the range $1.0Lambda(1405)$ and $p \\pi^0$ of the $\\Sigma^+$. Neither the standard (PDG) resonance parameters, nor free parameters fitting to a single Breit-Wigner resonance represent the line shape. In our fits, the line shape corresponds approximately to predictions of a two-pole meson-baryon picture of the $\\Lambda(1405)$, with a lower mass pole near 1368 MeV/c$^2$ and a higher mass pole near 1423 MeV/c$^2$. Furthermore, with increasing photon virtuality the mass distribution shifts toward the higher mass pole.

  13. Phase-dependent double-{\\Lambda} electromagnetically induced transparency

    CERN Document Server

    Chen, Yi-Hsin; Yu, Ite A; Chen, Ying-Cheng; Chen, Yong-Fan

    2014-01-01

    We theoretically investigate a double-{\\Lambda} electromagnetically induced transparency (EIT) system. The property of the double-{\\Lambda} medium with a closed-loop configuration depends on the relative phase of the applied laser fields. This phase-dependent mechanism differentiates the double-{\\Lambda} medium from the conventional Kerr-based nonlinear medium, e.g., EIT-based nonlinear medium discussed by Harris and Hau [Phys. Rev. Lett. 82, 4611 (1999)], which depends only on the intensities of the applied laser fields. Steady-state analytical solutions for the phase-dependent system are obtained by solving the Maxwell-Bloch equations. In addition, we discuss efficient all-optical phase modulation and coherent light amplification based on the proposed double-{\\Lambda} EIT scheme.

  14. Proof Systems for Retracts in Simply Typed Lambda Calculus

    OpenAIRE

    Stirling, Colin,

    2013-01-01

    This paper concerns retracts in simply typed lambda calculus assuming βη-equality. We provide a simple tableau proof system which characterises when a type is a retract of another type and which leads to an exponential decision procedure.

  15. Complete Cosmic History with a dynamical Lambda(H) term

    CERN Document Server

    Perico, E L D; Basilakos, Spyros; Sola, Joan

    2013-01-01

    In the present main-stream cosmology, matter and spacetime emerged from a singularity and evolved through four distinct periods: early inflation, radiation, dark matter and late time inflation (driven by dark energy). During the radiation and dark matter dominated stages the universe is decelerating while the early and late time inflations are accelerating stages. A possible connection between the accelerating periods remains unknown, and, even more intriguing, the best dark energy candidate powering the present accelerating stage (Lambda-vacuum) is plagued with the cosmological constant and coincidence puzzles. Here we propose an alternative solution for such problems based on a large class of time-dependent vacuum energy density models in the form of power series of the Hubble rate, Lambda=Lambda (H). The proposed class of Lambda(H)-decaying vacuum model provides: i) an alternative mechanism for inflation (beyond the usual inflaton models, some of them in serious trouble after the recent PLANCK release of a...

  16. High Resolution Spectroscopy of 16N#Lambda# by Electroproduction

    International Nuclear Information System (INIS)

    An experimental study of the 16O(e, e'K+)16N#Lambda# reaction has been performed at Jefferson Lab. A thin film of falling water was used as a target. This permitted a simultaneous measurement of the p(e, e'K+)Λ,Σ0 exclusive reactions and a precise calibration of the energy scale. A ground-state binding energy of 13.76 ± 0.16 MeV was obtained for 16N#Lambda# with better precision than previous measurements on the mirror hypernucleus 16O#Lambda#. Precise energies have been determined for peaks arising from a Lambda in s and p orbits coupled to the p1/2 and p3/2 hole states of the 15N core nucleus.

  17. LAMBDA - Legacy Archive for Microwave Background Data Analysis

    Data.gov (United States)

    National Aeronautics and Space Administration — The High Energy Astrophysics Science Archive Research Center (HEASARC) and the Legacy Archive for Microwave Background Data Analysis (LAMBDA) have merged into a...

  18. Coherent Theta^+ and Lambda(1520) photoproduction off the deuteron

    CERN Document Server

    Titov, A I; Daté, S; Ohashi, Y

    2005-01-01

    We analyze an effect of the coherent $\\Theta^+\\Lambda(1520)$ photoproduction in $\\gamma D$ interaction near the threshold. We demonstrate that the coherence effect becomes manifest in a comparison of the $nK^+$ invariant mass distribution when the $pK^-$ invariant equals the $\\Lambda(1520)$ mass. Our model calculations indicate a sizeable contribution of resonant and non-resonant background processes in the $\\gamma D\\to np K^+K^-$ reaction which generally exceed the contribution of the coherent resonant channel. However, we find that the coherent $\\Theta^+\\Lambda(1520)$ photoproduction is enhanced relative to the background processes in the forward hemisphere of the $pK^-$ pair photoproduction. Moreover, the coherence effect does not depend on the $\\Theta^+$ photoproduction amplitude and is defined by the probabilities of the $\\Lambda(1520)$ photoproduction and the $\\Theta^+\\to NK$ transition. Therefore, this coherence effect may be used as an independent method for studying the mechanism of $\\Theta^+$ produc...

  19. Automatic Binding Time Analysis for a Typed Lambda-Calculus

    DEFF Research Database (Denmark)

    Nielson, Hanne Riis; Nielson, Flemming

    1988-01-01

    A binding time analysis imposes a distinction between the computations to be performed early (e.g. at compile-time) and those to be performed late (e.g. at run-time). For the lambda-calculus this distinction is formalized by a two-level lambda-calculus. The authors present an algorithm for static...... analysis of the binding times of a typed lambda-calculus with products, sums, lists and general recursive types. Given partial information about the binding times of some of the subexpressions it will complete that information such that (i) early bindings may be turned into late bindings but not vice versa......, (ii) the resulting two-level lambda-expression reflects our intuition about binding times, e.g. that early bindings are performed before late bindings, and (iii) as few changes as possible have been made compared with the initial binding information. The results can be applied in the implementation...

  20. The call-by-need lambda calculus (unabridged).

    OpenAIRE

    Maraist, John; Odersky, Martin; Wadler, Phil

    2007-01-01

    We present a calculus that captures the operational semantics of call-by-need.We demonstrate that the calculus is confluent and standardizable and entails the same observational equivalences as call-by-name lambda calculus.

  1. Scaled momentum distributions for K0s and Lambda/bar Lambda in DIS at HERA

    CERN Document Server

    Abramowicz, H

    2012-01-01

    Scaled momentum distributions for the strange hadrons K0s and Lambda/bar Lambda were measured in deep inelastic ep scattering with the ZEUS detector at HERA using an integrated luminosity of 330 pb-1. The evolution of these distributions with the photon virtuality, Q2, was studied in the kinematic region 10 < Q2 < 40000 GeV2 and 0.001 < x < 0.75, where x is the Bjorken scaling variable. Clear scaling violations are observed. Predictions based on different approaches to fragmentation were compared to the measurements. Tuned leading-logarithm parton-shower Monte Carlo calculations interfaced to the Lund string fragmentation model describe the data reasonably well in the whole range measured. Next-to-leading-order QCD calculations based on fragmentation functions, FFs, extracted from e+e- data alone, fail to describe the measurements. The calculations based on FFs extracted from a global analysis including e+e-, ep and pp data give an improved description. The measurements presented in this paper hav...

  2. Analysis of $\\Lambda_{b} \\rightarrow$ $\\Lambda \\mu^{+} \\mu^{-}$ decay in scalar leptoquark model

    CERN Document Server

    Wang, Shuai-wei

    2016-01-01

    We analyze the baryonic semilepton decay $\\Lambda_{b} \\rightarrow$ $\\Lambda \\mu^{+} \\mu^{-}$ in the scalar leptoquark models with $X(3,2,7/6)$ and $X(3,2,1/6)$ states, respectively. We also discuss the effects of this two NP models on some physical observables. For some measured observables, like the differential decay width, the longitudinal polarization of the dilepton system, the lepton-side forward-backward asymmetry and the baryon-side forward-backward asymmetry, we find, the prediction values of SM are consistent with the current data in the most $q^{2}$ ranges, where the prediction values of this two NP models can also keep consistent with the current data with $1\\sigma$. However, in some $q^{2}$ ranges, the prediction values of SM are difficult to meet the current data, but the contributions of this two NP models can meet them or keep closer to them. For the double lepton polarization asymmetries, $P_{LT}$, $P_{TL}$, $P_{NN}$ and $P_{TT}$ are sensitive to the scalar leptoquark model $X(3,2,7/6)$ but n...

  3. Lambda production in the DIS target fragmentation region

    Energy Technology Data Exchange (ETDEWEB)

    Ceccopieri, Federico A. [Universite de Liege, IFPA, Liege (Belgium)

    2016-02-15

    By using a recently obtained set of Lambda fracture functions, we present predictions for Lambda production in the target fragmentation region of semi-inclusive deep inelastic scattering in CLAS rate at 12 GeV kinematics, supplemented with a conservative error estimate. We discuss a number of observables sensitive to the assumptions of the underlying theory and many of the assumptions of the proposed phenomenological model. (orig.)

  4. Shear-induced assembly of lambda-phage DNA.

    OpenAIRE

    Haber, C.; Wirtz, D

    2000-01-01

    Recombinant DNA technology, which is based on the assembly of DNA fragments, forms the backbone of biological and biomedical research. Here we demonstrate that a uniform shear flow can induce and control the assembly of lambda-phage DNA molecules: increasing shear rates form integral DNA multimers of increasing molecular weight. Spontaneous assembly and grouping of end-blunted lambda-phage DNA molecules are negligible. It is suggested that shear-induced DNA assembly is caused by increasing th...

  5. A high statistics measurement of the Lambda(+)(c) lifetime.

    Science.gov (United States)

    Link, J M; Reyes, M; Yager, P M; Anjos, J C; Bediaga, I; Göbel, C; Magnin, J; Massafferi, A; de Miranda, J M; Pepe, I M; dos Reis, A C; Carrillo, S; Casimiro, E; Cuautle, E; Sánchez-Hernández, A; Uribe, C; Vazquez, F; Agostino, L; Cinquini, L; Cumalat, J P; O'Reilly, B; Ramirez, J E; Segoni, I; Butler, J N; Cheung, H W K; Gaines, I; Garbincius, P H; Garren, L A; Gottschalk, E; Kasper, P H; Kreymer, A E; Kutschke, R; Bianco, S; Fabbri, F L; Zallo, A; Cawlfield, C; Kim, D Y; Rahimi, A; Wiss, J; Gardner, R; Kryemadhi, A; Chung, Y S; Kang, J S; Ko, B R; Kwak, J W; Lee, K B; Park, H; Alimonti, G; Boschini, M; D'Angelo, P; DiCorato, M; Dini, P; Giammarchi, M; Inzani, P; Leveraro, F; Malvezzi, S; Menasce, D; Mezzadri, M; Milazzo, L; Moroni, L; Pedrini, D; Pontoglio, C; Prelz, F; Rovere, M; Sala, S; Davenport, T F; Arena, V; Boca, G; Bonomi, G; Gianini, G; Liguori, G; Merlo, M M; Pantea, D; Ratti, S P; Riccardi, C; Vitulo, P; Hernandez, H; Lopez, A M; Luiggi, E; Mendez, H; Mendez, L; Mirles, A; Montiel, E; Olaya, D; Paris, A; Quinones, J; Rivera, C; Xiong, W; Zhang, Y; Wilson, J R; Cho, K; Handler, T; Mitchell, R; Engh, D; Hosack, M; Johns, W E; Nehring, M; Sheldon, P D; Stenson, K; Vaandering, E W; Webster, M; Sheaff, M

    2002-04-22

    A high statistics measurement of the Lambda(+)(c) lifetime from the Fermilab fixed-target FOCUS photoproduction experiment is presented. We describe the analysis technique with particular attention to the determination of the systematic uncertainty. The measured value of 204.6 +/- 3.4 (stat) +/- 2.5 (syst) fs from 8034 +/- 122 Lambda(+)(c)-->pK(-)pi(+) decays represents a significant improvement over the present world average. PMID:11955226

  6. M13 Bacteriophage Based Protein Sensors

    Science.gov (United States)

    Lee, Ju Hun

    Despite significant progress in biotechnology and biosensing, early detection and disease diagnosis remains a critical issue for improving patient survival rates and well-being. Many of the typical detection schemes currently used possess issues such as low sensitivity and accuracy and are also time consuming to run and expensive. In addition, multiplexed detection remains difficult to achieve. Therefore, developing advanced approaches for reliable, simple, quantitative analysis of multiple markers in solution that also are highly sensitive are still in demand. In recent years, much of the research has primarily focused on improving two key components of biosensors: the bio-recognition agent (bio-receptor) and the transducer. Particular bio-receptors that have been used include antibodies, aptamers, molecular imprinted polymers, and small affinity peptides. In terms of transducing agents, nanomaterials have been considered as attractive candidates due to their inherent nanoscale size, durability and unique chemical and physical properties. The key focus of this thesis is the design of a protein detection and identification system that is based on chemically engineered M13 bacteriophage coupled with nanomaterials. The first chapter provides an introduction of biosensors and M13 bacteriophage in general, where the advantages of each are provided. In chapter 2, an efficient and enzyme-free sensor is demonstrated from modified M13 bacteriophage to generate highly sensitive colorimetric signals from gold nanocrystals. In chapter 3, DNA conjugated M13 were used to enable facile and rapid detection of antigens in solution that also provides modalities for identification. Lastly, high DNA loadings per phage was achieved via hydrozone chemistry and these were applied in conjunction with Raman active DNA-gold/silver core/shell nanoparticles toward highly sensitive SERS sensing.

  7. Ecological study of bacteriophages of Vibrio natriegens

    Energy Technology Data Exchange (ETDEWEB)

    Zachary, A.

    1978-03-01

    Effects of temperature and anaerobic conditions on the replication of two bacteriophages, nt-1 and nt-6, of the estuarine bacterium Vibrio natriegens were studied. Reduction in temperature resulted in longer latent periods and reduced burst sizes for both phages. Replication under anaerobic conditions resulted in longer latent periods; however, phage nt-6 had a reduced burst size, whereas phage nt-1 had an increased burst size, resulting in a rate of phage production nearly equal to that observed under aerobic conditions. Therefore the distribution of the phages in marsh areas could be influenced by temperature and anaerobiosis.

  8. Bacteriophage biosensors for antibiotic-resistant bacteria.

    Science.gov (United States)

    Sorokulova, Irina; Olsen, Eric; Vodyanoy, Vitaly

    2014-03-01

    An increasing number of disease-causing bacteria are resistant to one or more anti-bacterial drugs utilized for therapy. Early and speedy detection of these pathogens is therefore very important. Traditional pathogen detection techniques, that include microbiological and biochemical assays are long and labor-intensive, while antibody or DNA-based methods require substantial sample preparation and purification. Biosensors based on bacteriophages have demonstrated remarkable potential to surmount these restrictions and to offer rapid, efficient and sensitive detection technique for antibiotic-resistant bacteria.

  9. Role of $Y(4630)$ in the $p\\bar{p}\\rightarrow\\Lambda_c\\bar{\\Lambda}_c$ reaction near threshold

    CERN Document Server

    Wang, Yan-Yan; Wang, En; li, De-Min

    2016-01-01

    We investigate the charmed baryon production reaction $p\\bar{p}\\rightarrow\\Lambda_c\\bar{\\Lambda}_c$ in an effective Lagrangian approach. Besides the $t$-channel $D^0$ and $D^{*0}$ mesons exchanges, the $s$-channel $Y(4630)$ meson exchange is taken into account. For the total cross sections, the $D^0$ and $D^{*0}$ mesons provide minor background contributions, while the $Y(4630)$ state gives a clear peak structure with the magnitude of 10 $\\mu$b at center of mass energy 4.63 GeV. Basing on the results, we suggest that the reaction of $p\\bar{p}\\rightarrow\\Lambda_c\\bar{\\Lambda}_c$ can be used to search for the $1^{--}$ charmonium-like $Y(4630)$ state, and our predictions can be tested in future by the $\\rm{\\bar PANDA}$ facility.

  10. Differential branching fraction and angular analysis of $\\Lambda^{0}_{b} \\rightarrow \\Lambda^0 \\mu^+\\mu^-$ decays

    CERN Document Server

    Aaij, Roel; Adinolfi, Marco; Affolder, Anthony; Ajaltouni, Ziad; Akar, Simon; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio Augusto; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; An, Liupan; Anderlini, Lucio; Anderson, Jonathan; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Aquines Gutierrez, Osvaldo; Archilli, Flavio; Artamonov, Alexander; Artuso, Marina; Aslanides, Elie; Auriemma, Giulio; Baalouch, Marouen; Bachmann, Sebastian; Back, John; Badalov, Alexey; Baesso, Clarissa; Baldini, Wander; Barlow, Roger; Barschel, Colin; Barsuk, Sergey; Barter, William; Batozskaya, Varvara; Battista, Vincenzo; Bay, Aurelio; Beaucourt, Leo; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Bel, Lennaert; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Benton, Jack; Berezhnoy, Alexander; Bernet, Roland; Bertolin, Alessandro; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bien, Alexander; Bifani, Simone; Bird, Thomas; Bizzeti, Andrea; Blake, Thomas; Blanc, Frédéric; Blouw, Johan; Blusk, Steven; Bocci, Valerio; Bondar, Alexander; Bondar, Nikolay; Bonivento, Walter; Borghi, Silvia; Borsato, Martino; Bowcock, Themistocles; Bowen, Espen Eie; Bozzi, Concezio; Braun, Svende; Brett, David; Britsch, Markward; Britton, Thomas; Brodzicka, Jolanta; Brook, Nicholas; Bursche, Albert; Buytaert, Jan; Cadeddu, Sandro; Calabrese, Roberto; Calvi, Marta; Calvo Gomez, Miriam; Campana, Pierluigi; Campora Perez, Daniel; Capriotti, Lorenzo; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carniti, Paolo; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casanova Mohr, Raimon; Casse, Gianluigi; Cassina, Lorenzo; Castillo Garcia, Lucia; Cattaneo, Marco; Cauet, Christophe; Cavallero, Giovanni; Cenci, Riccardo; Charles, Matthew; Charpentier, Philippe; Chefdeville, Maximilien; Chen, Shanzhen; Cheung, Shu-Faye; Chiapolini, Nicola; Chrzaszcz, Marcin; Cid Vidal, Xabier; Ciezarek, Gregory; Clarke, Peter; Clemencic, Marco; Cliff, Harry; Closier, Joel; Coco, Victor; Cogan, Julien; Cogneras, Eric; Cogoni, Violetta; Cojocariu, Lucian; Collazuol, Gianmaria; Collins, Paula; Comerma-Montells, Albert; Contu, Andrea; Cook, Andrew; Coombes, Matthew; Coquereau, Samuel; Corti, Gloria; Corvo, Marco; Counts, Ian; Couturier, Benjamin; Cowan, Greig; Craik, Daniel Charles; Crocombe, Andrew; Cruz Torres, Melissa Maria; Cunliffe, Samuel; Currie, Robert; D'Ambrosio, Carmelo; Dalseno, Jeremy; David, Pieter; Davis, Adam; De Bruyn, Kristof; De Capua, Stefano; De Cian, Michel; De Miranda, Jussara; De Paula, Leandro; De Silva, Weeraddana; De Simone, Patrizia; Dean, Cameron Thomas; Decamp, Daniel; Deckenhoff, Mirko; Del Buono, Luigi; Déléage, Nicolas; Derkach, Denis; Deschamps, Olivier; Dettori, Francesco; Dey, Biplab; Di Canto, Angelo; Di Ruscio, Francesco; Dijkstra, Hans; Donleavy, Stephanie; Dordei, Francesca; Dorigo, Mirco; Dosil Suárez, Alvaro; Dossett, David; Dovbnya, Anatoliy; Dreimanis, Karlis; Dujany, Giulio; Dupertuis, Frederic; Durante, Paolo; Dzhelyadin, Rustem; Dziurda, Agnieszka; Dzyuba, Alexey; Easo, Sajan; Egede, Ulrik; Egorychev, Victor; Eidelman, Semen; Eisenhardt, Stephan; Eitschberger, Ulrich; Ekelhof, Robert; Eklund, Lars; El Rifai, Ibrahim; Elsasser, Christian; Ely, Scott; Esen, Sevda; Evans, Hannah Mary; Evans, Timothy; Falabella, Antonio; Färber, Christian; Farinelli, Chiara; Farley, Nathanael; Farry, Stephen; Fay, Robert; Ferguson, Dianne; Fernandez Albor, Victor; Ferrari, Fabio; Ferreira Rodrigues, Fernando; Ferro-Luzzi, Massimiliano; Filippov, Sergey; Fiore, Marco; Fiorini, Massimiliano; Firlej, Miroslaw; Fitzpatrick, Conor; Fiutowski, Tomasz; Fol, Philip; Fontana, Marianna; Fontanelli, Flavio; Forty, Roger; Francisco, Oscar; Frank, Markus; Frei, Christoph; Frosini, Maddalena; Fu, Jinlin; Furfaro, Emiliano; Gallas Torreira, Abraham; Galli, Domenico; Gallorini, Stefano; Gambetta, Silvia; Gandelman, Miriam; Gandini, Paolo; Gao, Yuanning; García Pardiñas, Julián; Garofoli, Justin; Garra Tico, Jordi; Garrido, Lluis; Gascon, David; Gaspar, Clara; Gastaldi, Ugo; Gauld, Rhorry; Gavardi, Laura; Gazzoni, Giulio; Geraci, Angelo; Gerick, David; Gersabeck, Evelina; Gersabeck, Marco; Gershon, Timothy; Ghez, Philippe; Gianelle, Alessio; Gianì, Sebastiana; Gibson, Valerie; Giubega, Lavinia-Helena; Gligorov, Vladimir; Göbel, Carla; Golubkov, Dmitry; Golutvin, Andrey; Gomes, Alvaro; Gotti, Claudio; Grabalosa Gándara, Marc; Graciani Diaz, Ricardo; Granado Cardoso, Luis Alberto; Graugés, Eugeni; Graverini, Elena; Graziani, Giacomo; Grecu, Alexandru; Greening, Edward; Gregson, Sam; Griffith, Peter; Grillo, Lucia; Grünberg, Oliver; Gui, Bin; Gushchin, Evgeny; Guz, Yury; Gys, Thierry; Hadjivasiliou, Christos; Haefeli, Guido; Haen, Christophe; Haines, Susan; Hall, Samuel; Hamilton, Brian; Hampson, Thomas; Han, Xiaoxue; Hansmann-Menzemer, Stephanie; Harnew, Neville; Harnew, Samuel; Harrison, Jonathan; He, Jibo; Head, Timothy; Heijne, Veerle; Hennessy, Karol; Henrard, Pierre; Henry, Louis; Hernando Morata, Jose Angel; van Herwijnen, Eric; Heß, Miriam; Hicheur, Adlène; Hill, Donal; Hoballah, Mostafa; Hombach, Christoph; Hulsbergen, Wouter; Humair, Thibaud; Hussain, Nazim; Hutchcroft, David; Hynds, Daniel; Idzik, Marek; Ilten, Philip; Jacobsson, Richard; Jaeger, Andreas; Jalocha, Pawel; Jans, Eddy; Jawahery, Abolhassan; Jing, Fanfan; John, Malcolm; Johnson, Daniel; Jones, Christopher; Joram, Christian; Jost, Beat; Jurik, Nathan; Kandybei, Sergii; Kanso, Walaa; Karacson, Matthias; Karbach, Moritz; Karodia, Sarah; Kelsey, Matthew; Kenyon, Ian; Kenzie, Matthew; Ketel, Tjeerd; Khanji, Basem; Khurewathanakul, Chitsanu; Klaver, Suzanne; Klimaszewski, Konrad; Kochebina, Olga; Kolpin, Michael; Komarov, Ilya; Koopman, Rose; Koppenburg, Patrick; Korolev, Mikhail; Kravchuk, Leonid; Kreplin, Katharina; Kreps, Michal; Krocker, Georg; Krokovny, Pavel; Kruse, Florian; Kucewicz, Wojciech; Kucharczyk, Marcin; Kudryavtsev, Vasily; Kurek, Krzysztof; Kvaratskheliya, Tengiz; La Thi, Viet Nga; Lacarrere, Daniel; Lafferty, George; Lai, Adriano; Lambert, Dean; Lambert, Robert W; Lanfranchi, Gaia; Langenbruch, Christoph; Langhans, Benedikt; Latham, Thomas; Lazzeroni, Cristina; Le Gac, Renaud; van Leerdam, Jeroen; Lees, Jean-Pierre; Lefèvre, Regis; Leflat, Alexander; Lefrançois, Jacques; Leroy, Olivier; Lesiak, Tadeusz; Leverington, Blake; Li, Yiming; Likhomanenko, Tatiana; Liles, Myfanwy; Lindner, Rolf; Linn, Christian; Lionetto, Federica; Liu, Bo; Lohn, Stefan; Longstaff, Iain; Lopes, Jose; Lowdon, Peter; Lucchesi, Donatella; Luo, Haofei; Lupato, Anna; Luppi, Eleonora; Lupton, Oliver; Machefert, Frederic; Maciuc, Florin; Maev, Oleg; Malde, Sneha; Malinin, Alexander; Manca, Giulia; Mancinelli, Giampiero; Manning, Peter Michael; Mapelli, Alessandro; Maratas, Jan; Marchand, Jean François; Marconi, Umberto; Marin Benito, Carla; Marino, Pietro; Märki, Raphael; Marks, Jörg; Martellotti, Giuseppe; Martinelli, Maurizio; Martinez Santos, Diego; Martinez Vidal, Fernando; Martins Tostes, Danielle; Massafferri, André; Matev, Rosen; Mathad, Abhijit; Mathe, Zoltan; Matteuzzi, Clara; Mauri, Andrea; Maurin, Brice; Mazurov, Alexander; McCann, Michael; McCarthy, James; McNab, Andrew; McNulty, Ronan; Meadows, Brian; Meier, Frank; Meissner, Marco; Merk, Marcel; Milanes, Diego Alejandro; Minard, Marie-Noelle; Mitzel, Dominik Stefan; Molina Rodriguez, Josue; Monteil, Stephane; Morandin, Mauro; Morawski, Piotr; Mordà, Alessandro; Morello, Michael Joseph; Moron, Jakub; Morris, Adam Benjamin; Mountain, Raymond; Muheim, Franz; Müller, Katharina; Mussini, Manuel; Muster, Bastien; Naik, Paras; Nakada, Tatsuya; Nandakumar, Raja; Nasteva, Irina; Needham, Matthew; Neri, Nicola; Neubert, Sebastian; Neufeld, Niko; Neuner, Max; Nguyen, Anh Duc; Nguyen, Thi-Dung; Nguyen-Mau, Chung; Niess, Valentin; Niet, Ramon; Nikitin, Nikolay; Nikodem, Thomas; Novoselov, Alexey; O'Hanlon, Daniel Patrick; Oblakowska-Mucha, Agnieszka; Obraztsov, Vladimir; Ogilvy, Stephen; Okhrimenko, Oleksandr; Oldeman, Rudolf; Onderwater, Gerco; Osorio Rodrigues, Bruno; Otalora Goicochea, Juan Martin; Otto, Adam; Owen, Patrick; Oyanguren, Maria Aranzazu; Palano, Antimo; Palombo, Fernando; Palutan, Matteo; Panman, Jacob; Papanestis, Antonios; Pappagallo, Marco; Pappalardo, Luciano; Parkes, Christopher; Passaleva, Giovanni; Patel, Girish; Patel, Mitesh; Patrignani, Claudia; Pearce, Alex; Pellegrino, Antonio; Penso, Gianni; Pepe Altarelli, Monica; Perazzini, Stefano; Perret, Pascal; Pescatore, Luca; Petridis, Konstantin; Petrolini, Alessandro; Picatoste Olloqui, Eduardo; Pietrzyk, Boleslaw; Pilař, Tomas; Pinci, Davide; Pistone, Alessandro; Playfer, Stephen; Plo Casasus, Maximo; Poikela, Tuomas; Polci, Francesco; Poluektov, Anton; Polyakov, Ivan; Polycarpo, Erica; Popov, Alexander; Popov, Dmitry; Popovici, Bogdan; Potterat, Cédric; Price, Eugenia; Price, Joseph David; Prisciandaro, Jessica; Pritchard, Adrian; Prouve, Claire; Pugatch, Valery; Puig Navarro, Albert; Punzi, Giovanni; Qian, Wenbin; Quagliani, Renato; Rachwal, Bartolomiej; Rademacker, Jonas; Rakotomiaramanana, Barinjaka; Rama, Matteo; Rangel, Murilo; Raniuk, Iurii; Rauschmayr, Nathalie; Raven, Gerhard; Redi, Federico; Reichert, Stefanie; Reid, Matthew; dos Reis, Alberto; Ricciardi, Stefania; Richards, Sophie; Rihl, Mariana; Rinnert, Kurt; Rives Molina, Vincente; Robbe, Patrick; Rodrigues, Ana Barbara; Rodrigues, Eduardo; Rodriguez Lopez, Jairo Alexis; Rodriguez Perez, Pablo; Roiser, Stefan; Romanovsky, Vladimir; Romero Vidal, Antonio; Rotondo, Marcello; Rouvinet, Julien; Ruf, Thomas; Ruiz, Hugo; Ruiz Valls, Pablo; Saborido Silva, Juan Jose; Sagidova, Naylya; Sail, Paul; Saitta, Biagio; Salustino Guimaraes, Valdir; Sanchez Mayordomo, Carlos; Sanmartin Sedes, Brais; Santacesaria, Roberta; Santamarina Rios, Cibran; Santovetti, Emanuele; Sarti, Alessio; Satriano, Celestina; Satta, Alessia; Saunders, Daniel Martin; Savrina, Darya; Schiller, Manuel; Schindler, Heinrich; Schlupp, Maximilian; Schmelling, Michael; Schmidt, Burkhard; Schneider, Olivier; Schopper, Andreas; Schune, Marie Helene; Schwemmer, Rainer; Sciascia, Barbara; Sciubba, Adalberto; Semennikov, Alexander; Sepp, Indrek; Serra, Nicola; Serrano, Justine; Sestini, Lorenzo; Seyfert, Paul; Shapkin, Mikhail; Shapoval, Illya; Shcheglov, Yury; Shears, Tara; Shekhtman, Lev; Shevchenko, Vladimir; Shires, Alexander; Silva Coutinho, Rafael; Simi, Gabriele; Sirendi, Marek; Skidmore, Nicola; Skillicorn, Ian; Skwarnicki, Tomasz; Smith, Anthony; Smith, Edmund; Smith, Eluned; Smith, Jackson; Smith, Mark; Snoek, Hella; Sokoloff, Michael; Soler, Paul; Soomro, Fatima; Souza, Daniel; Souza De Paula, Bruno; Spaan, Bernhard; Spradlin, Patrick; Sridharan, Srikanth; Stagni, Federico; Stahl, Marian; Stahl, Sascha; Steinkamp, Olaf; Stenyakin, Oleg; Sterpka, Christopher Francis; Stevenson, Scott; Stoica, Sabin; Stone, Sheldon; Storaci, Barbara; Stracka, Simone; Straticiuc, Mihai; Straumann, Ulrich; Stroili, Roberto; Sun, Liang; Sutcliffe, William; Swientek, Krzysztof; Swientek, Stefan; Syropoulos, Vasileios; Szczekowski, Marek; Szczypka, Paul; Szumlak, Tomasz; T'Jampens, Stephane; Teklishyn, Maksym; Tellarini, Giulia; Teubert, Frederic; Thomas, Christopher; Thomas, Eric; van Tilburg, Jeroen; Tisserand, Vincent; Tobin, Mark; Todd, Jacob; Tolk, Siim; Tomassetti, Luca; Tonelli, Diego; Topp-Joergensen, Stig; Torr, Nicholas; Tournefier, Edwige; Tourneur, Stephane; Trabelsi, Karim; Tran, Minh Tâm; Tresch, Marco; Trisovic, Ana; Tsaregorodtsev, Andrei; Tsopelas, Panagiotis; Tuning, Niels; Ukleja, Artur; Ustyuzhanin, Andrey; Uwer, Ulrich; Vacca, Claudia; Vagnoni, Vincenzo; Valenti, Giovanni; Vallier, Alexis; Vazquez Gomez, Ricardo; Vazquez Regueiro, Pablo; Vázquez Sierra, Carlos; Vecchi, Stefania; Velthuis, Jaap; Veltri, Michele; Veneziano, Giovanni; Vesterinen, Mika; Viana Barbosa, Joao Vitor; Viaud, Benoit; Vieira, Daniel; Vieites Diaz, Maria; Vilasis-Cardona, Xavier; Vollhardt, Achim; Volyanskyy, Dmytro; Voong, David; Vorobyev, Alexey; Vorobyev, Vitaly; Voß, Christian; de Vries, Jacco; Waldi, Roland; Wallace, Charlotte; Wallace, Ronan; Walsh, John; Wandernoth, Sebastian; Wang, Jianchun; Ward, David; Watson, Nigel; Websdale, David; Weiden, Andreas; Whitehead, Mark; Wiedner, Dirk; Wilkinson, Guy; Wilkinson, Michael; Williams, Mark Richard James; Williams, Matthew; Williams, Mike; Wilson, Fergus; Wimberley, Jack; Wishahi, Julian; Wislicki, Wojciech; Witek, Mariusz; Wormser, Guy; Wotton, Stephen; Wright, Simon; Wyllie, Kenneth; Xie, Yuehong; Xu, Zhirui; Yang, Zhenwei; Yuan, Xuhao; Yushchenko, Oleg; Zangoli, Maria; Zavertyaev, Mikhail; Zhang, Liming; Zhang, Yanxi; Zhelezov, Alexey; Zhokhov, Anatoly; Zhong, Liang

    2015-01-01

    The differential branching fraction of the rare decay $\\Lambda^{0}_{b} \\rightarrow \\Lambda^0 \\mu^+\\mu^-$ is measured as a function of $q^{2}$, the square of the dimuon invariant mass. The analysis is performed using proton-proton collision data, corresponding to an integrated luminosity of $3.0 \\mbox{ fb}^{-1}$, collected by the LHCb experiment. Evidence of signal is observed in the $q^2$ region below the square of the $J/\\psi$ mass. Integrating over $15 < q^{2} < 20 \\mbox{ GeV}^2/c^4$ the branching fraction is measured as $d\\mathcal{B}(\\Lambda^{0}_{b} \\rightarrow \\Lambda^0 \\mu^+\\mu^-)/dq^2 = (1.18 ^{+ 0.09} _{-0.08} \\pm 0.03 \\pm 0.27) \\times 10^{-7} ( \\mbox{GeV}^{2}/c^{4})^{-1}$, where the uncertainties are statistical, systematic and due to the normalisation mode, $\\Lambda^{0}_{b} \\rightarrow J/\\psi \\Lambda^0$, respectively. In the $q^2$ intervals where the signal is observed, angular distributions are studied and the forward-backward asymmetries in the dimuon ($A^{l}_{\\rm FB}$) and hadron ($A^{h}_{\\r...

  11. The semileptonic decay Lambda_b -> Lambda_c + tau(-) + antinu_tau in the covariant confined quark model

    CERN Document Server

    Gutsche, Thomas; Korner, Jurgen G; Lyubovitskij, Valery E; Santorelli, Pietro; Habyl, Nurgul

    2015-01-01

    Recently there has been much interest in the tauonic semileptonic meson decays B -> D+ tau + nu_tau and B -> D* + tau + nu_tau where one has found larger rates than what is predicted by the Standard Model. We analyze the corresponding semileptonic baryon decays Lambda_b(0) -> Lambda_c(+) + tau(-) + antinu_tau with particular emphasis on the lepton helicity flip and scalar contributions which vanish for zero lepton masses. We calculate the total rate, differential decay distributions, the longitudinal and transverse polarization of the daughter baryon Lambda_c(+) and the tau-lepton, and the lepton-side forward-backward asymmetries. The nonvanishing polarization of the daughter baryon Lambda_c(+) leads to hadron-side asymmetries in e.g. the decay Lambda_c(+) -> Lambda(0) + pi(+) and azimuthal correlations between the two final state decay planes which we specify. We provide numerical results on these observables using results of the covariant confined quark model. We find large lepton mass effects in the q2-spe...

  12. P-wave Lambda N - Sigma N coupling and the spin-orbit splitting of 9 Lambda Be

    CERN Document Server

    Fujiwara, Y; Suzuki, Y

    2008-01-01

    We reexamine the spin-orbit splitting of 9 Lambda Be excited states in terms of the SU_6 quark-model baryon-baryon interaction. The previous folding procedure to generate the Lambda alpha spin-orbit potential from the quark-model Lambda N LS interaction kernel predicted three to five times larger values for Delta E_{ell s}=E_x(3/2^+)-E_x(5/2^+) in the model FSS and fss2. This time, we calculate Lambda alpha LS Born kernel, starting from the LS components of the nuclear-matter G-matrix for the Lambda hyperon. This framework makes it possible to take full account of an important P-wave Lambda N - Sigma N coupling through the antisymmetric LS^{(-)} force involved in the Fermi-Breit interaction. We find that the experimental value, Delta E^{exp}_{ell s}=43 pm 5 keV, is reproduced by the quark-model G-matrix LS interaction with a Fermi-momentum around k_F=1.0 fm^{-1}, when the model FSS is used in the energy-independent renormalized RGM formalism.

  13. Bacteriophages and Their Role in Food Safety

    Directory of Open Access Journals (Sweden)

    Sanna M. Sillankorva

    2012-01-01

    Full Text Available The interest for natural antimicrobial compounds has increased due to alterations in consumer positions towards the use of chemical preservatives in foodstuff and food processing surfaces. Bacteriophages fit in the class of natural antimicrobial and their effectiveness in controlling bacterial pathogens in agro-food industry has led to the development of different phage products already approved by USFDA and USDA. The majority of these products are to be used in farm animals or animal products such as carcasses, meats and also in agricultural and horticultural products. Treatment with specific phages in the food industry can prevent the decay of products and the spread of bacterial diseases and ultimately promote safe environments in animal and plant food production, processing, and handling. This is an overview of recent work carried out with phages as tools to promote food safety, starting with a general introduction describing the prevalence of foodborne pathogens and bacteriophages and a more detailed discussion on the use of phage therapy to prevent and treat experimentally induced infections of animals against the most common foodborne pathogens, the use of phages as biocontrol agents in foods, and also their use as biosanitizers of food contact surfaces.

  14. Bacteriophage recombination systems and biotechnical applications.

    Science.gov (United States)

    Nafissi, Nafiseh; Slavcev, Roderick

    2014-04-01

    Bacteriophage recombination systems have been widely used in biotechnology for modifying prokaryotic species, for creating transgenic animals and plants, and more recently, for human cell gene manipulation. In contrast to homologous recombination, which benefits from the endogenous recombination machinery of the cell, site-specific recombination requires an exogenous source of recombinase in mammalian cells. The mechanism of bacteriophage evolution and their coexistence with bacterial cells has become a point of interest ever since bacterial viruses' life cycles were first explored. Phage recombinases have already been exploited as valuable genetic tools and new phage enzymes, and their potential application to genetic engineering and genome manipulation, vectorology, and generation of new transgene delivery vectors, and cell therapy are attractive areas of research that continue to be investigated. The significance and role of phage recombination systems in biotechnology is reviewed in this paper, with specific focus on homologous and site-specific recombination conferred by the coli phages, λ, and N15, the integrase from the Streptomyces phage, ΦC31, the recombination system of phage P1, and the recently characterized recombination functions of Yersinia phage, PY54. Key steps of the molecular mechanisms involving phage recombination functions and their application to molecular engineering, our novel exploitations of the PY54-derived recombination system, and its application to the development of new DNA vectors are discussed.

  15. Understanding Bacteriophage Specificity in Natural Microbial Communities

    Directory of Open Access Journals (Sweden)

    Britt Koskella

    2013-03-01

    Full Text Available Studying the coevolutionary dynamics between bacteria and the bacteriophage viruses that infect them is critical to understanding both microbial diversity and ecosystem functioning. Phages can play a key role in shaping bacterial population dynamics and can significantly alter both intra- and inter-specific competition among bacterial hosts. Predicting how phages might influence community stability and apparent competition, however, requires an understanding of how bacteria-phage interaction networks evolve as a function of host diversity and community dynamics. Here, we first review the progress that has been made in understanding phage specificity, including the use of experimental evolution, we then introduce a new dataset on natural bacteriophages collected from the phyllosphere of horse chestnut trees, and finally we highlight that bacterial sensitivity to phage is rarely a binary trait and that this variation should be taken into account and reported. We emphasize that there is currently insufficient evidence to make broad generalizations about phage host range in natural populations, the limits of phage adaptation to novel hosts, or the implications of phage specificity in shaping microbial communities. However, the combination of experimental and genomic approaches with the study of natural communities will allow new insight to the evolution and impact of phage specificity within complex bacterial communities.

  16. Bacteriophage recombination systems and biotechnical applications.

    Science.gov (United States)

    Nafissi, Nafiseh; Slavcev, Roderick

    2014-04-01

    Bacteriophage recombination systems have been widely used in biotechnology for modifying prokaryotic species, for creating transgenic animals and plants, and more recently, for human cell gene manipulation. In contrast to homologous recombination, which benefits from the endogenous recombination machinery of the cell, site-specific recombination requires an exogenous source of recombinase in mammalian cells. The mechanism of bacteriophage evolution and their coexistence with bacterial cells has become a point of interest ever since bacterial viruses' life cycles were first explored. Phage recombinases have already been exploited as valuable genetic tools and new phage enzymes, and their potential application to genetic engineering and genome manipulation, vectorology, and generation of new transgene delivery vectors, and cell therapy are attractive areas of research that continue to be investigated. The significance and role of phage recombination systems in biotechnology is reviewed in this paper, with specific focus on homologous and site-specific recombination conferred by the coli phages, λ, and N15, the integrase from the Streptomyces phage, ΦC31, the recombination system of phage P1, and the recently characterized recombination functions of Yersinia phage, PY54. Key steps of the molecular mechanisms involving phage recombination functions and their application to molecular engineering, our novel exploitations of the PY54-derived recombination system, and its application to the development of new DNA vectors are discussed. PMID:24442504

  17. Primary structure and functional analysis of the lysis genes of Lactobacillus gasseri bacteriophage phi adh.

    Science.gov (United States)

    Henrich, B; Binishofer, B; Bläsi, U

    1995-01-01

    The lysis genes of the Lactobacillus gasseri bacteriophage phi adh were isolated by complementation of a lambda Sam mutation in Escherichia coli. Nucleotide sequencing of a 1,735-bp DNA fragment revealed two adjacent coding regions of 342 bp (hol) and 951 bp (lys) in the same reading frame which appear to belong to a common transcriptional unit. Proteins corresponding to the predicted gene products, holin (12.9 kDa) and lysin (34.7 kDa), were identified by in vitro and in vivo expression of the cloned genes. The phi adh holin is a membrane-bound protein with structural similarity to lysis proteins of other phage, known to be required for the transit of murein hydrolases through the cytoplasmic membrane. The phi adh lysin shows homology with mureinolytic enzymes encoded by the Lactobacillus bulgaricus phage mv4, the Streptococcus pneumoniae phage Cp-1, Cp-7, and Cp-9, and the Lactococcus lactis phage phi LC3. Significant homology with the N termini of known muramidases suggests that phi adh lysin acts by a similar catalytic mechanism. In E. coli, the phi adh lysin seems to be associated with the total membrane fraction, from which it can be extracted with lauryl sarcosinate. Either one of the phi adh lysis proteins provoked lysis of E. coli when expressed along with holins or lysins of phage lambda or Bacillus subtilis phage phi 29. Concomitant expression of the combined holin and lysin functions of phi adh in E. coli, however, did not result in efficient cell lysis. PMID:7836307

  18. Primary structure and functional analysis of the lysis genes of Lactobacillus gasseri bacteriophage phi adh.

    Science.gov (United States)

    Henrich, B; Binishofer, B; Bläsi, U

    1995-02-01

    The lysis genes of the Lactobacillus gasseri bacteriophage phi adh were isolated by complementation of a lambda Sam mutation in Escherichia coli. Nucleotide sequencing of a 1,735-bp DNA fragment revealed two adjacent coding regions of 342 bp (hol) and 951 bp (lys) in the same reading frame which appear to belong to a common transcriptional unit. Proteins corresponding to the predicted gene products, holin (12.9 kDa) and lysin (34.7 kDa), were identified by in vitro and in vivo expression of the cloned genes. The phi adh holin is a membrane-bound protein with structural similarity to lysis proteins of other phage, known to be required for the transit of murein hydrolases through the cytoplasmic membrane. The phi adh lysin shows homology with mureinolytic enzymes encoded by the Lactobacillus bulgaricus phage mv4, the Streptococcus pneumoniae phage Cp-1, Cp-7, and Cp-9, and the Lactococcus lactis phage phi LC3. Significant homology with the N termini of known muramidases suggests that phi adh lysin acts by a similar catalytic mechanism. In E. coli, the phi adh lysin seems to be associated with the total membrane fraction, from which it can be extracted with lauryl sarcosinate. Either one of the phi adh lysis proteins provoked lysis of E. coli when expressed along with holins or lysins of phage lambda or Bacillus subtilis phage phi 29. Concomitant expression of the combined holin and lysin functions of phi adh in E. coli, however, did not result in efficient cell lysis. PMID:7836307

  19. Measurements of the $\\Lambda_b^0 \\to J/\\psi \\Lambda$ decay amplitudes and the $\\Lambda_b^0$ polarisation in $pp$ collisions at $\\sqrt{s} = 7$ TeV

    CERN Document Server

    Aaij, R; Adeva, B; Adinolfi, M; Adrover, C; Affolder, A; Ajaltouni, Z; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves Jr, A A; Amato, S; Amerio, S; Amhis, Y; Anderlini, L; Anderson, J; Andreassen, R; Appleby, R B; Aquines Gutierrez, O; Archilli, F; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Bachmann, S; Back, J J; Baesso, C; Balagura, V; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Bauer, Th; Bay, A; Beddow, J; Bedeschi, F; Bediaga, I; Belogurov, S; Belous, K; Belyaev, I; Ben-Haim, E; Benayoun, M; Bencivenni, G; Benson, S; Benton, J; Berezhnoy, A; Bernet, R; Bettler, M -O; van Beuzekom, M; Bien, A; Bifani, S; Bird, T; Bizzeti, A; Bjørnstad, P M; Blake, T; Blanc, F; Blouw, J; Blusk, S; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borghi, S; Borgia, A; Bowcock, T J V; Bowen, E; Bozzi, C; Brambach, T; van den Brand, J; Bressieux, J; Brett, D; Britsch, M; Britton, T; Brook, N H; Brown, H; Burducea, I; Bursche, A; Busetto, G; Buytaert, J; Cadeddu, S; Callot, O; Calvi, M; Calvo Gomez, M; Camboni, A; Campana, P; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carranza-Mejia, H; Carson, L; Carvalho Akiba, K; Casse, G; Cattaneo, M; Cauet, Ch; Charles, M; Charpentier, Ph; Chen, P; Chiapolini, N; Chrzaszcz, M; Ciba, K; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coca, C; Coco, V; Cogan, J; Cogneras, E; Collins, P; Comerma-Montells, A; Contu, A; Cook, A; Coombes, M; Coquereau, S; Corti, G; Couturier, B; Cowan, G A; Craik, D; Cunliffe, S; Currie, R; D'Ambrosio, C; David, P; David, P N Y; De Bonis, I; De Bruyn, K; De Capua, S; De Cian, M; De Miranda, J M; De Oyanguren Campos, M; De Paula, L; De Silva, W; De Simone, P; Decamp, D; Deckenhoff, M; Del Buono, L; Derkach, D; Deschamps, O; Dettori, F; Di Canto, A; Dijkstra, H; Dogaru, M; Donleavy, S; Dordei, F; Dosil Suárez, A; Dossett, D; Dovbnya, A; Dupertuis, F; Dzhelyadin, R; Dziurda, A; Dzyuba, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; van Eijk, D; Eisenhardt, S; Eitschberger, U; Ekelhof, R; Eklund, L; El Rifai, I; Elsasser, Ch; Elsby, D; Falabella, A; Färber, C; Fardell, G; Farinelli, C; Farry, S; Fave, V; Ferguson, D; Fernandez Albor, V; Ferreira Rodrigues, F; Ferro-Luzzi, M; Filippov, S; Fitzpatrick, C; Fontana, M; Fontanelli, F; Forty, R; Francisco, O; Frank, M; Frei, C; Frosini, M; Furcas, S; Furfaro, E; Gallas Torreira, A; Galli, D; Gandelman, M; Gandini, P; Gao, Y; Garofoli, J; Garosi, P; Garra Tico, J; Garrido, L; Gaspar, C; Gauld, R; Gersabeck, E; Gersabeck, M; Gershon, T; Ghez, Ph; Gibson, V; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gordon, H; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graziani, G; Grecu, A; Greening, E; Gregson, S; Grünberg, O; Gui, B; Gushchin, E; Guz, Yu; Gys, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hall, S; Hampson, T; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; Hartmann, T; He, J; Heijne, V; Hennessy, K; Henrard, P; Hernando Morata, J A; van Herwijnen, E; Hicks, E; Hill, D; Hoballah, M; Hombach, C; Hopchev, P; Hulsbergen, W; Hunt, P; Huse, T; Hussain, N; Hutchcroft, D; Hynds, D; Iakovenko, V; Idzik, M; Ilten, P; Jacobsson, R; Jaeger, A; Jans, E; Jaton, P; Jing, F; John, M; Johnson, D; Jones, C R; Jost, B; Kaballo, M; Kandybei, S; Karacson, M; Karbach, T M; Kenyon, I R; Kerzel, U; Ketel, T; Keune, A; Khanji, B; Kochebina, O; Komarov, I; Koopman, R F; Koppenburg, P; Korolev, M; Kozlinskiy, A; Kravchuk, L; Kreplin, K; Kreps, M; Krocker, G; Krokovny, P; Kruse, F; Kucharczyk, M; Kudryavtsev, V; Kvaratskheliya, T; La Thi, V N; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lambert, R W; Lanciotti, E; Lanfranchi, G; Langenbruch, C; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J -P; Lefèvre, R; Leflat, A; Lefrançois, J; Leo, S; Leroy, O; Leverington, B; Li, Y; Li Gioi, L; Liles, M; Lindner, R; Linn, C; Liu, B; Liu, G; von Loeben, J; Lohn, S; Lopes, J H; Lopez Asamar, E; Lopez-March, N; Lu, H; Lucchesi, D; Luisier, J; Luo, H; Machefert, F; Machikhiliyan, I V; Maciuc, F; Maev, O; Malde, S; Manca, G; Mancinelli, G; Marconi, U; Märki, R; Marks, J; Martellotti, G; Martens, A; Martin, L; Martín Sánchez, A; Martinelli, M; Martinez Santos, D; Martins Tostes, D; Massafferri, A; Matev, R; Mathe, Z; Matteuzzi, C; Maurice, E; Mazurov, A; McCarthy, J; McNulty, R; Mcnab, A; Meadows, B; Meier, F; Meissner, M; Merk, M; Milanes, D A; Minard, M -N; Molina Rodriguez, J; Monteil, S; Moran, D; Morawski, P; Morello, M J; Mountain, R; Mous, I; Muheim, F; Müller, K; Muresan, R; Muryn, B; Muster, B; Naik, P; Nakada, T; Nandakumar, R; Nasteva, I; Needham, M; Neufeld, N; Nguyen, A D; Nguyen, T D; Nguyen-Mau, C; Nicol, M; Niess, V; Niet, R; Nikitin, N; Nikodem, T; Nomerotski, A; Novoselov, A; Oblakowska-Mucha, A; Obraztsov, V; Oggero, S; Ogilvy, S; Okhrimenko, O; Oldeman, R; Orlandea, M; Otalora Goicochea, J M; Owen, P; Pal, B K; Palano, A; Palutan, M; Panman, J; Papanestis, A; Pappagallo, M; Parkes, C; Parkinson, C J; Passaleva, G; Patel, G D; Patel, M; Patrick, G N; Patrignani, C; Pavel-Nicorescu, C; Pazos Alvarez, A; Pellegrino, A; Penso, G; Pepe Altarelli, M; Perazzini, S; Perego, D L; Perez Trigo, E; Pérez-Calero Yzquierdo, A; Perret, P; Perrin-Terrin, M; Pessina, G; Petridis, K; Petrolini, A; Phan, A; Picatoste Olloqui, E; Pietrzyk, B; Pilař, T; Pinci, D; Playfer, S; Plo Casasus, M; Polci, F; Polok, G; Poluektov, A; Polycarpo, E; Popov, D; Popovici, B; Potterat, C; Powell, A; Prisciandaro, J; Pugatch, V; Puig Navarro, A; Punzi, G; Qian, W; Rademacker, J H; Rakotomiaramanana, B; Rangel, M S; Raniuk, I; Rauschmayr, N; Raven, G; Redford, S; Reid, M M; dos Reis, A C; Ricciardi, S; Richards, A; Rinnert, K; Rives Molina, V; Roa Romero, D A; Robbe, P; Rodrigues, E; Rodriguez Perez, P; Roiser, S; Romanovsky, V; Romero Vidal, A; Rouvinet, J; Ruf, T; Ruffini, F; Ruiz, H; Ruiz Valls, P; Sabatino, G; Saborido Silva, J J; Sagidova, N; Sail, P; Saitta, B; Salzmann, C; Sanmartin Sedes, B; Sannino, M; Santacesaria, R; Santamarina Rios, C; Santovetti, E; Sapunov, M; Sarti, A; Satriano, C; Satta, A; Savrie, M; Savrina, D; Schaack, P; Schiller, M; Schindler, H; Schlupp, M; Schmelling, M; Schmidt, B; Schneider, O; Schopper, A; Schune, M -H; Schwemmer, R; Sciascia, B; Sciubba, A; Seco, M; Semennikov, A; Senderowska, K; Sepp, I; Serra, N; Serrano, J; Seyfert, P; Shapkin, M; Shapoval, I; Shatalov, P; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, O; Shevchenko, V; Shires, A; Silva Coutinho, R; Skwarnicki, T; Smith, N A; Smith, E; Smith, M; Sokoloff, M D; Soler, F J P; Soomro, F; Souza, D; Souza De Paula, B; Spaan, B; Sparkes, A; Spradlin, P; Stagni, F; Stahl, S; Steinkamp, O; Stoica, S; Stone, S; Storaci, B; Straticiuc, M; Straumann, U; Subbiah, V K; Swientek, S; Syropoulos, V; Szczekowski, M; Szczypka, P; Szumlak, T; T'Jampens, S; Teklishyn, M; Teodorescu, E; Teubert, F; Thomas, C; Thomas, E; van Tilburg, J; Tisserand, V; Tobin, M; Tolk, S; Tonelli, D; Topp-Joergensen, S; Torr, N; Tournefier, E; Tourneur, S; Tran, M T; Tresch, M; Tsaregorodtsev, A; Tsopelas, P; Tuning, N; Ubeda Garcia, M; Ukleja, A; Urner, D; Uwer, U; Vagnoni, V; Valenti, G; Vazquez Gomez, R; Vazquez Regueiro, P; Vecchi, S; Velthuis, J J; Veltri, M; Veneziano, G; Vesterinen, M; Viaud, B; Vieira, D; Vilasis-Cardona, X; Vollhardt, A; Volyanskyy, D; Voong, D; Vorobyev, A; Vorobyev, V; Voß, C; Voss, H; Waldi, R; Wallace, R; Wandernoth, S; Wang, J; Ward, D R; Watson, N K; Webber, A D; Websdale, D; Whitehead, M; Wicht, J; Wiechczynski, J; Wiedner, D; Wiggers, L; Wilkinson, G; Williams, M P; Williams, M; Wilson, F F; Wishahi, J; Witek, M; Wotton, S A; Wright, S; Wu, S; Wyllie, K; Xie, Y; Xing, F; Xing, Z; Yang, Z; Young, R; Yuan, X; Yushchenko, O; Zangoli, M; Zavertyaev, M; Zhang, F; Zhang, L; Zhang, W C; Zhang, Y; Zhelezov, A; Zhokhov, A; Zhong, L; Zvyagin, A

    2013-01-01

    An angular analysis of $\\Lambda_b^0 \\to J/\\psi \\Lambda$ decays is performed using a data sample corresponding to $1.0$ ${\\rm fb}^{-1}$ collected in $pp$ collisions at $\\sqrt{s} = 7$ TeV with the LHCb detector at the LHC. A parity violating asymmetry parameter characterising the $\\Lambda_b^0 \\to J/\\psi \\Lambda$ decay of $0.05 \\pm 0.17 \\pm 0.07$ and a $\\Lambda_b^0$ transverse production polarisation of $0.06 \\pm 0.07 \\pm 0.02$ are measured, where the first uncertainty is statistical and the second systematic.

  20. The interactome of Streptococcus pneumoniae and its bacteriophages show highly specific patterns of interactions among bacteria and their phages.

    Science.gov (United States)

    Mariano, Rachelle; Wuchty, Stefan; Vizoso-Pinto, Maria G; Häuser, Roman; Uetz, Peter

    2016-04-22

    Although an abundance of bacteriophages exists, little is known about interactions between their proteins and those of their bacterial hosts. Here, we experimentally determined the phage-host interactomes of the phages Dp-1 and Cp-1 and their underlying protein interaction network in the host Streptococcus pneumoniae. We compared our results to the interaction patterns of E. coli phages lambda and T7. Dp-1 and Cp-1 target highly connected host proteins, occupy central network positions, and reach many protein clusters through the interactions of their targets. In turn, lambda and T7 targets cluster to conserved and essential proteins in E. coli, while such patterns were largely absent in S. pneumoniae. Furthermore, targets in E. coli were mutually strongly intertwined, while targets of Dp-1 and Cp-1 were strongly connected through essential and orthologous proteins in their immediate network vicinity. In both phage-host systems, the impact of phages on their protein targets appears to extend from their network neighbors, since proteins that interact with phage targets were located in central network positions, have a strong topologically disruptive effect and touch complexes with high functional heterogeneity. Such observations suggest that the phages, biological impact is accomplished through a surprisingly limited topological reach of their targets.

  1. Combined use of Bacteriophage K and a novel Bacteriophage to reduce Staphylococcus aureus biofilm formation

    DEFF Research Database (Denmark)

    Alves, D.R.; Gaudion, A.; Bean, J.E.;

    2014-01-01

    Biofilms are major causes of impairment of wound healing and patient morbidity. One of the most common and aggressive wound pathogens is Staphylococcus aureus, displaying a large repertoire of virulence factors and commonly reduced susceptibility to antibiotics, such as the spread of methicillin-......-resistant S. aureus (MRSA). Bacteriophages are obligate parasites of bacteria. They multiply intracellularly and lyse their bacterial host, releasing their progeny. We isolated a novel phage, DRA88, which has a ...

  2. Correlated inclusive $\\Lambda \\overline{Lambda}$ production in $e^{+}e^{-}$ annihilations at $\\sqrt{s~}$10.5 GeV

    CERN Document Server

    Metreveli, Z V; Tomaradze, A G; Zweber, P; Ahmed, S; Alam, M S; Jian, L; Saleem, M; Wappler, F; Eckhart, E; Gan, K K; Gwon, C; Hart, T; Honscheid, K; Hufnagel, D; Kagan, H; Kass, R; Pedlar, T K; Thayer, J B; Wilksen, T; Zoeller, M M; Muramatsu, H; Richichi, S J; Severini, H; Skubic, P L; Dytman, S A; Müller, J A; Nam, S; Savinov, V; Chen, S; Hinson, J W; Lee, J; Miller, D H; Pavlunin, V; Shibata, E I; Shipsey, I P J; Cronin-Hennessy, D; Lyon, A L; Park, C S; Park, W; Thorndike, E H; Coan, T E; Gao, Y S; Liu, F; Maravin, Y; Narsky, I; Stroynowski, R; Artuso, M; Boulahouache, C; Bukin, K; Dambasuren, E; Khroustalev, K; Moneti, G C; Mountain, R; Nandakumar, R; Skwarnicki, T; Stone, S; Wang, J C; Mahmood, A H; Csorna, S E; Danko, I; Xu, Z; Bonvicini, G; Cinabro, D; Dubrovin, M; McGee, S; Bornheim, A; Lipeles, E; Pappas, S P; Shapiro, A; Sun, W M; Weinstein, A J; Masek, G; Paar, H P; Mahapatra, R; Briere, R A; Chen, G P; Ferguson, T; Tatishvili, G T; Vogel, H; Adam, N E; Alexander, J P; Berkelman, K; Blanc, F; Boisvert, V; Cassel, David G; Drell, P S; Duboscq, J E; Ecklund, K M; Ehrlich, R; Galik, R S; Gibbons, L; Gittelman, B; Gray, S W; Hartill, D L; Heltsley, B K; Hsu, L; Jones, C D; Kandaswamy, J; Kreinick, D L; Magerkurth, A; Mahlke-Krüger, H; Meyer, T O; Mistry, N B; Nordberg, E; Patterson, J R; Peterson, D; Pivarski, J; Riley, D; Sadoff, A J; Schwarthoff, H; Shepherd, M R; Thayer, J G; Urner, D; Valant-Spaight, B L; Viehhauser, G; Warburton, A; Weinberger, M; Athar, S B; Avery, P; Breva-Newell, L; Potlia, V; Stöck, H; Yelton, J; Brandenburg, G; Ershov, A; Kim, D Y J; Wilson, R; Benslama, K; Eisenstein, B I; Ernst, J; Gollin, G D; Hans, R M; Karliner, I; Lowrey, N; Marsh, M A; Plager, C; Sedlack, C; Selen, M; Thaler, J J; Williams, J; Edwards, K W; Ammar, R; Besson, D; Cervantes, M; Zhao, X; Anderson, S; Frolov, V V; Kubota, Y; Lee, S J; Li, S Z; Poling, R A; Smith, A; Stepaniak, C J; Urheim, J; 10.1103/PhysRevD.66.052002

    2002-01-01

    Using a 13.7 fb/sup -1/ sample of continuum two-jet e/sup +/e/sup -/ to qq events collected with the CLEO detector, we have searched for correlations between Lambda and Lambda particles, specifically in cases where the opening angle between the two particles is large and each has momentum >1 GeV/c. Such correlations may indicate the presence of baryon number conservation at the primary quark level. A previous CLEO study of Lambda /sub c/ Lambda /sub c/ correlations indicated direct, associated production of primary charmed baryons Lambda /sub c/: e/sup +/e/sup -/ to cc to Lambda /sub c/ Lambda /sub c/. That effect was not observed in Monte Carlo simulations. Our current search for similar direct, associated production of Lambda baryons at the primary quark level (e/sup +/e/sup -/ to ss to Lambda Lambda , e.g.) qualitatively indicates a similar effect, although it relies on a Monte Carlo dependent subtraction of background Lambda Lambda production (based on the default JETSET 7.4 event generator). (12 refs).

  3. First observation and measurement of the resonant structure of the lambda_b->lambda_c pi-pi+pi- decay mode

    Energy Technology Data Exchange (ETDEWEB)

    Azzurri, P.; Barria, P.; Ciocci, M.A.; Donati, S.; Vataga, E.

    2009-12-01

    The authors present the first observation of the {Lambda}{sub b}{sup 0} {yields} {Lambda}{sub c}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -} decay using data from an integrated luminosity of approximately 2.4 fb{sup -1} of p{bar p} collisions at {radical}s = 1.96 TeV, collected with the CDF II detector at the Fermilab Tevatron. They also present the first observation of the resonant decays {Lambda}{sub b}{sup 0} {yields} {Sigma}{sub c}(2455){sup 0} {pi}{sup +}{pi}{sup -} {yields} {Lambda}{sub c}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -}, {Lambda}{sub b}{sup 0} {yields} {Sigma}{sub c}(2455){sup ++}{pi}{sup -}{pi}{sup -} {yields} {Lambda}{sub c}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -}, {Lambda}{sub b}{sup 0} {yields} {Lambda}{sub c}(2595){sup +}{pi}{sup -} {yields} {Lambda}{sub c}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -} and {Lambda}{sub b}{sup 0} {yields} {Lambda}{sub c}(2625){sup +}{pi}{sup -} {yields} {Lambda}{sub c}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -}, and measure their relative branching ratios.

  4. Measurement of Singly Cabibbo-Suppressed Decays $\\Lambda_c^{+}\\to p\\pi^{+}\\pi^{-}$ and $\\Lambda_c^{+}\\to pK^{+}K^{-}$

    CERN Document Server

    Ablikim, M; Ahmed, S; Ai, X C; Albayrak, O; Albrecht, M; Ambrose, D J; Amoroso, A; An, F F; An, Q; Bai, J Z; Bakina, O; Ferroli, R Baldini; Ban, Y; Bennett, D W; Bennett, J V; Berger, N; Bertani, M; Bettoni, D; Bian, J M; Bianchi, F; Boger, E; Boyko, I; Briere, R A; Cai, H; Cai, X; Cakir, O; Calcaterra, A; Cao, G F; Cetin, S A; Chai, J; Chang, J F; Chelkov, G; Chen, G; Chen, H S; Chen, J C; Chen, M L; Chen, S; Chen, S J; Chen, X; Chen, X R; Chen, Y B; Cheng, H P; Chu, X K; Cibinetto, G; Dai, H L; Dai, J P; Dbeyssi, A; Dedovich, D; Deng, Z Y; Denig, A; Denysenko, I; Destefanis, M; De Mori, F; Ding, Y; Dong, C; Dong, J; Dong, L Y; Dong, M Y; Dou, Z L; Du, S X; Duan, P F; Fan, J Z; Fang, J; Fang, S S; Fang, X; Fang, Y; Farinelli, R; Fava, L; Fegan, S; Feldbauer, F; Felici, G; Feng, C Q; Fioravanti, E; Fritsch, M; Fu, C D; Gao, Q; Gao, X L; Gao, Y; Gao, Z; Garzia, I; Goetzen, K; Gong, L; Gong, W X; Gradl, W; Greco, M; Gu, M H; Gu, Y T; Guan, Y H; Guo, A Q; Guo, L B; Guo, R P; Guo, Y; Guo, Y P; Haddadi, Z; Hafner, A; Han, S; Hao, X Q; Harris, F A; He, K L; Heinsius, F H; Held, T; Heng, Y K; Holtmann, T; Hou, Z L; Hu, C; Hu, H M; Hu, J F; Hu, T; Hu, Y; Huang, G S; Huang, J S; Huang, X T; Huang, X Z; Huang, Y; Huang, Z L; Hussain, T; Andersson, W Ikegami; Ji, Q; Ji, Q P; Ji, X B; Ji, X L; Jiang, L W; Jiang, X S; Jiang, X Y; Jiao, J B; Jiao, Z; Jin, D P; Jin, S; Johansson, T; Julin, A; Kalantar-Nayestanaki, N; Kang, X L; Kang, X S; Kavatsyuk, M; Ke, B C; Kiese, P; Kliemt, R; Kloss, B; Kolcu, O B; Kopf, B; Kornicer, M; Kupsc, A; Kühn, W; Lange, J S; Lara, M; Larin, P; Leithoff, H; Leng, C; Li, C; Li, Cheng; Li, D M; Li, F; Li, F Y; Li, G; Li, H B; Li, H J; Li, J C; Li, Jin; Li, K; Li, K; Li, Lei; Li, P L; Li, P R; Li, Q Y; Li, T; Li, W D; Li, W G; Li, X L; Li, X N; Li, X Q; Li, Y B; Li, Z B; Liang, H; Liang, Y F; Liang, Y T; Liao, G R; Lin, D X; Liu, B; Liu, B J; Liu, C X; Liu, D; Liu, F H; Liu, Fang; Liu, Feng; Liu, H B; Liu, H H; Liu, H H; Liu, H M; Liu, J; Liu, J B; Liu, J P; Liu, J Y; Liu, K; Liu, K Y; Liu, L D; Liu, P L; Liu, Q; Liu, S B; Liu, X; Liu, Y B; Liu, Y Y; Liu, Z A; Liu, Zhiqing; Loehner, H; Long, Y F; Lou, X C; Lu, H J; Lu, J G; Lu, Y; Lu, Y P; Luo, C L; Luo, M X; Luo, T; Luo, X L; Lyu, X R; Ma, F C; Ma, H L; Ma, L L; Ma, M M; Ma, Q M; Ma, T; Ma, X N; Ma, X Y; Ma, Y M; Maas, F E; Maggiora, M; Malik, Q A; Mao, Y J; Mao, Z P; Marcello, S; Messchendorp, J G; Mezzadri, G; Min, J; Min, T J; Mitchell, R E; Mo, X H; Mo, Y J; Morales, C Morales; Muchnoi, N Yu; Muramatsu, H; Musiol, P; Nefedov, Y; Nerling, F; Nikolaev, I B; Ning, Z; Nisar, S; Niu, S L; Niu, X Y; Olsen, S L; Ouyang, Q; Pacetti, S; Pan, Y; Patteri, P; Pelizaeus, M; Peng, H P; Peters, K; Pettersson, J; Ping, J L; Ping, R G; Poling, R; Prasad, V; Qi, H R; Qi, M; Qian, S; Qiao, C F; Qin, L Q; Qin, N; Qin, X S; Qin, Z H; Qiu, J F; Rashid, K H; Redmer, C F; Ripka, M; Rong, G; Rosner, Ch; Ruan, X D; Sarantsev, A; Savrié, M; Schnier, C; Schumann, K Schoenning S; Shan, W; Shao, M; Shen, C P; Shen, P X; Shen, X Y; Sheng, H Y; Shi, M; Song, W M; Song, X Y; Sosio, S; Spataro, S; Sun, G X; Sun, J F; Sun, S S; Sun, X H; Sun, Y J; Sun, Y Z; Sun, Z J; Sun, Z T; Tang, C J; Tang, X; Tapan, I; Thorndike, E H; Tiemens, M; Uman, I; Varner, G S; Wang, B; Wang, B L; Wang, D; Wang, D Y; Wang, K; Wang, L L; Wang, L S; Wang, M; Wang, P; Wang, P L; Wang, W; Wang, W P; Wang, X F; Wang, Y; Wang, Y D; Wang, Y F; Wang, Y Q; Wang, Z; Wang, Z G; Wang, Z H; Wang, Z Y; Wang, Z Y; Weber, T; Wei, D H; Weidenkaff, P; Wen, S P; Wiedner, U; Wolke, M; Wu, L H; Wu, L J; Wu, Z; Xia, L; Xia, L G; Xia, Y; Xiao, D; Xiao, H; Xiao, Z J; Xie, Y G; Xiu, Q L; Xu, G F; Xu, J J; Xu, L; Xu, Q J; Xu, Q N; Xu, X P; Yan, L; Yan, W B; Yan, W C; Yan, Y H; Yang, H J; Yang, H X; Yang, L; Yang, Y X; Ye, M; Ye, M H; Yin, J H; You, Z Y; Yu, B X; Yu, C X; Yu, J S; Yuan, C Z; Yuan, W L; Yuan, Y; Yuncu, A; Zafar, A A; Zallo, A; Zeng, Y; Zeng, Z; Zhang, B X; Zhang, B Y; Zhang, C; Zhang, C C; Zhang, D H; Zhang, H H; Zhang, H Y; Zhang, J; Zhang, J J; Zhang, J L; Zhang, J Q; Zhang, J W; Zhang, J Y; Zhang, J Z; Zhang, K; Zhang, L; Zhang, S Q; Zhang, X Y; Zhang, Y; Zhang, Y; Zhang, Y H; Zhang, Y N; Zhang, Y T; Zhang, Yu; Zhang, Z H; Zhang, Z P; Zhang, Z Y; Zhao, G; Zhao, J W; Zhao, J Y; Zhao, J Z; Zhao, Lei; Zhao, Ling; Zhao, M G; Zhao, Q; Zhao, Q W; Zhao, S J; Zhao, T C; Zhao, Y B; Zhao, Z G; Zhemchugov, A; Zheng, B; Zheng, J P; Zheng, W J; Zheng, Y H; Zhong, B; Zhou, L; Zhou, X; Zhou, X K; Zhou, X R; Zhou, X Y; Zhu, K; Zhu, K J; Zhu, S; Zhu, S H; Zhu, X L; Zhu, Y C; Zhu, Y S; Zhu, Z A; Zhuang, J; Zotti, L; Zou, B S; Zou, J H

    2016-01-01

    Using 567 $pb^{-1}$ of data collected with the BESIII detector at a center-of-mass energy of $\\sqrt{s}=$ 4.599 $GeV$, near the $\\Lambda_{c}^{+}\\Lambda_{c}^{-}$ threshold, we study the singly Cabibbo-suppressed decays $\\Lambda_c^{+}\\to p\\pi^{+}\\pi^{-}$ and $\\Lambda_c^{+}\\to pK^{+}K^{-}$. By normalizing with respect to the Cabibbo-favored decay $\\Lambda_c^{+}\\to pK^{-}\\pi^{+}$, we obtain ratios of branching fractions: $\\frac{\\mathcal{B}(\\Lambda_c^{+}\\to p\\pi^{+}\\pi^{-})}{\\mathcal{B}(\\Lambda_c^{+}\\to pK^{-}\\pi^{+})}$ = $(6.70 \\pm 0.48 \\pm 0.25)\\%$, $\\frac{\\mathcal{B}(\\Lambda_c^{+}\\to p\\phi)}{\\mathcal{B}(\\Lambda_c^{+}\\to pK^{-}\\pi^{+})}$ = $(1.81 \\pm 0.33 \\pm 0.13)\\%$, and $\\frac{\\mathcal{B}(\\Lambda_c^{+}\\to pK^{+}K^{-}_{\\text{non-}\\phi})}{\\mathcal{B}(\\Lambda_c^{+}\\to pK^{-}\\pi^{+})}$ = $(9.36 \\pm 2.22 \\pm 0.71)\\times10^{-3}$, where the uncertainties are statistical and systematic, respectively. The absolute branching fractions are also presented. Among these measurements, the decay $\\Lambda_c^{+}\\to p\\pi^{+}\\pi^...

  5. A Measurement of the Recoil Polarization of Electroproduced {Lambda}(1116)

    Energy Technology Data Exchange (ETDEWEB)

    Simeon McAleer

    2002-01-01

    The CEBAF Large Acceptance Spectrometer at the Thomas Jefferson National Laboratory was used to study the reaction e + p {yields} e{prime} + K{sup +} + {Lambda}(1116) for events where {Lambda}(1116) subsequently decayed via the channel {Lambda}(1116) {yields} p + {pi}{sup -}. Data were taken at incident electron beam energies of 2.5, 4.0, and 4.2 GeV during the 1999 E1C run period. They hyperon production spectra span the Q{sup 2} range from 0.5 to 2.8 GeV{sup 2} and nearly the entire range in the center of mass angles. The proton angular distribution in the {Lambda}(1116) rest frame is used to deduce the recoil polarization of the hyperon, and the W and cos {theta}{sub cm}{sup K+} dependence of the recoil polarization will be presented. The data show sizeable negative polarizations for the {Lambda}(1116) as a function of both cos {theta}{sub cm}{sup K+} and W.

  6. Production asymmetries of $D^{\\pm}$, $\\Lambda_c^{+}/\\Lambda_c^{-}$ and $\\Lambda_b^0/\\overline{\\Lambda}_b^0$ at the LHC from heavy quark recombination mechanism

    CERN Document Server

    Lai, Wai Kin

    2015-01-01

    The asymmetry in the forward region production cross section of $D^{\\pm}$ is calculated using the heavy quark recombination mechanism for $pp$ collisions at $7$~TeV. By suitable choices of four nonperturbative parameters, our calculated results can reproduce those obtained at LHCb. We find $A_p\\sim-1\\%$ when integrated over $2.0\\textrm{ GeV}Lambda_c^{+}/\\Lambda_c^{-}$ and $\\Lambda_b^0/\\overline{\\Lambda}_b^0$ for $pp$ collisions at $7$~TeV and $14$~TeV in the forward region. We find that the integrated asymmetries for these $\\Lambda$ baryons in the LHCb region are of the order of $\\sim1-3\\%$ and should be measurable.

  7. Bacteria vs. Bacteriophages: Parallel Evolution of Immune Arsenals.

    Science.gov (United States)

    Shabbir, Muhammad A B; Hao, Haihong; Shabbir, Muhammad Z; Wu, Qin; Sattar, Adeel; Yuan, Zonghui

    2016-01-01

    Bacteriophages are the most common entities on earth and represent a constant challenge to bacterial populations. To fend off bacteriophage infection, bacteria evolved immune systems to avert phage adsorption and block invader DNA entry. They developed restriction-modification systems and mechanisms to abort infection and interfere with virion assembly, as well as newly recognized clustered regularly interspaced short palindromic repeats (CRISPR). In response to bacterial immune systems, bacteriophages synchronously evolved resistance mechanisms, such as the anti-CRISPR systems to counterattack bacterial CRISPR-cas systems, in a continuing evolutionary arms race between virus and host. In turn, it is fundamental to the survival of the bacterial cell to evolve a system to combat bacteriophage immune strategies.

  8. Bacteria vs. bacteriophages: parallel evolution of immune arsenals

    Directory of Open Access Journals (Sweden)

    Muhammad Abu Bakr Shabbir

    2016-08-01

    Full Text Available Bacteriophages are the most common entities on earth and represent a constant challenge to bacterial populations. To fend off bacteriophage infection, bacteria evolved immune systems to avert phage adsorption and block invader DNA entry. They developed restriction-modification systems and mechanisms to abort infection and interfere with virion assembly, as well as newly recognized clustered regularly interspaced short palindromic repeats (CRISPR. In response to bacterial immune systems, bacteriophages synchronously evolved resistance mechanisms, such as the anti-CRISPR systems to counterattack bacterial CRISPR-cas systems, in a continuing evolutionary arms race between virus and host. In turn, it is fundamental to the survival of the bacterial cell to evolve a system to combat bacteriophage immune strategies.

  9. Antimicrobial bacteriophage-derived proteins and therapeutic applications

    Science.gov (United States)

    Antibiotics have the remarkable power to control bacterial infections. Unfortunately, widespread use, whether regarded as prudent or not, has favored the emergence and persistence of antibiotic resistant strains of human pathogenic bacteria, resulting in a global health threat. Bacteriophages (pha...

  10. Bacteriophages, revitalized after 100 years in the shadow of antibiotics

    Institute of Scientific and Technical Information of China (English)

    Hongping; Wei

    2015-01-01

    <正>The year 2015 marks 100 years since Dr.Frederick Twort discovered the"filterable lytic factor",which was later independently discovered and named "bacteriophage" by Dr.Felix d’Herelle.On this memorable centennial,it is exciting to see a special issue published by Virologica Sinica on Phages and Therapy.In this issue,readers will not only fi nd that bacteriophage research is a

  11. Bacteriophage-based nanoprobes for rapid bacteria separation

    Science.gov (United States)

    Chen, Juhong; Duncan, Bradley; Wang, Ziyuan; Wang, Li-Sheng; Rotello, Vincent M.; Nugen, Sam R.

    2015-10-01

    The lack of practical methods for bacterial separation remains a hindrance for the low-cost and successful development of rapid detection methods from complex samples. Antibody-tagged magnetic particles are commonly used to pull analytes from a liquid sample. While this method is well-established, improvements in capture efficiencies would result in an increase of the overall detection assay performance. Bacteriophages represent a low-cost and more consistent biorecognition element as compared to antibodies. We have developed nanoscale bacteriophage-tagged magnetic probes, where T7 bacteriophages were bound to magnetic nanoparticles. The nanoprobe allowed the specific recognition and attachment to E. coli cells. The phage magnetic nanprobes were directly compared to antibody-conjugated magnetic nanoprobes. The capture efficiencies of bacteriophages and antibodies on nanoparticles for the separation of E. coli K12 at varying concentrations were determined. The results indicated a similar bacteria capture efficiency between the two nanoprobes.The lack of practical methods for bacterial separation remains a hindrance for the low-cost and successful development of rapid detection methods from complex samples. Antibody-tagged magnetic particles are commonly used to pull analytes from a liquid sample. While this method is well-established, improvements in capture efficiencies would result in an increase of the overall detection assay performance. Bacteriophages represent a low-cost and more consistent biorecognition element as compared to antibodies. We have developed nanoscale bacteriophage-tagged magnetic probes, where T7 bacteriophages were bound to magnetic nanoparticles. The nanoprobe allowed the specific recognition and attachment to E. coli cells. The phage magnetic nanprobes were directly compared to antibody-conjugated magnetic nanoprobes. The capture efficiencies of bacteriophages and antibodies on nanoparticles for the separation of E. coli K12 at varying

  12. Targeting Antibacterial Agents by Using Drug-Carrying Filamentous Bacteriophages

    OpenAIRE

    Yacoby, Iftach; Shamis, Marina; Bar, Hagit; Shabat, Doron; Benhar, Itai

    2006-01-01

    Bacteriophages have been used for more than a century for (unconventional) therapy of bacterial infections, for half a century as tools in genetic research, for 2 decades as tools for discovery of specific target-binding proteins, and for nearly a decade as tools for vaccination or as gene delivery vehicles. Here we present a novel application of filamentous bacteriophages (phages) as targeted drug carriers for the eradication of (pathogenic) bacteria. The phages are genetically modified to d...

  13. Alternative bacteriophage life cycles: the carrier state of Campylobacter jejuni

    OpenAIRE

    Siringan, Patcharin; Connerton, Phillippa L.; Cummmings, Nicola J.; Connerton, Ian F.

    2014-01-01

    Members of the genus Campylobacter are frequently responsible for human enteric disease, often through consumption of contaminated poultry products. Bacteriophages are viruses that have the potential to control pathogenic bacteria, but understanding their complex life cycles is key to their successful exploitation. Treatment of Campylobacter jejuni biofilms with bacteriophages led to the discovery that phages had established a relationship with their hosts typical of the carrier state life cy...

  14. Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy

    OpenAIRE

    Lu, Timothy K.; Collins, James J.

    2009-01-01

    Antimicrobial drug development is increasingly lagging behind the evolution of antibiotic resistance, and as a result, there is a pressing need for new antibacterial therapies that can be readily designed and implemented. In this work, we engineered bacteriophage to overexpress proteins and attack gene networks that are not directly targeted by antibiotics. We show that suppressing the SOS network in Escherichia coli with engineered bacteriophage enhances killing by quinolones by several orde...

  15. Search for very light lambda hypernuclei in proton induced reactions

    Energy Technology Data Exchange (ETDEWEB)

    Kingler, J.; Ernst, J.; Hinterberger, F.; Jahn, R.; Lippert, C. [Bonn Univ. (Germany). ISKP; Boivin, M. [Laboratoire National de Saturne, F-91191 Gif-sur-Yvette (France); Didelez, J.P.; Frascaria, R.; Rappenecker, G.; Warde, E. [IPN, IN2P3-CNRS, F-91406 Orsay CEDEX (France)

    1998-05-11

    Proton-induced associated strangeness production of bound hypernuclei is accompanied by large momentum transfers. Therefore, the hyperon sticking probability is low and strongly depends on short range correlations. The most favourite reactions D(p,K{sup +}){sup 3}{sub {Lambda}}H, {sup 3}He(p,K{sup +}){sup 4}{sub {Lambda}}He and {sup 4}He(p,K{sup +}){sup 5}{sub {Lambda}}He were studied at LNS Saclay using the high resolution spectrometer SPES4 at {theta}{sub lab}{approx}7 {sup circle}. Background pions and protons were eliminated by aerogel veto-counters and several TOF cuts, respectively. The tracking of remaining kaon-like events through four horizontally and two vertically resolving drift chambers showed no evidence for respective g.s. transitions above background. Upper limits of the order of nb/sr (CMS) are deduced. (orig.) 16 refs.

  16. First Results on 12Lambda-C production at DAPHNE

    CERN Document Server

    Agnello, M; Benussi, L; Bertani, M; Bhang, H C; Bianco, S; Botta, E; Bregant, M; Bressani, Tullio; Busso, L; Calvo, D; Camerini, P; Caponero, M; Cerello, P; Dalena, B; De Mori, F; D'Erasmo, G; Di Santo, D; Donà, R; Elia, D; Fabbri, F L; Faso, D; Feliciello, A; Filippi, A; Filippini, V; Fini, R; Fiore, M E; Fujioka, H; Gianotti, P; Grion, N; Krasnoperov, A V; Lucherini, V; Lenti, V; Manzari, V; Marcello, S; Maruta, T; Mirfakhraee, N; Morra, O; Nagae, T; Olin, A; Outa, H; Pace, E; Pallotta, M; Palomba, M; Pantaleo, A; Panzarasa, A; Paticchio, V; Piano, S; Pompili, F; Rui, R; Simonetti, G; So, H; Tereshchenko, V V; Tomassini, S; Toyoda, A; Wheadon, R; Zenoni, A

    2005-01-01

    Lambda-hypernuclei are produced and studied, with the FINUDA spectrometer, for the first time at an e+e- collider: DAPHNE, the Frascati phi-factory. The slow negative kaons from phi(1020) decay are stopped in thin (0.2 g/cm^2) nuclear targets, and Lambda-hypernuclei formation is detected by measuring the momentum of the outgoing pi^-. A preliminary analysis on 12Lambda-C shows an energy resolution of 1.29 MeV FWHM on the hypernuclear levels, the best obtained so far with magnetic spectrometers at hadron facilities. Capture rates for the ground state and the excited ones are reported, and compared with previous experiments.

  17. Scale dependence of. Lambda. sub MS from deep inelastic scattering

    Energy Technology Data Exchange (ETDEWEB)

    Martin, A.D.; Stirling, W.J. (Dept. of Physics, Univ. of Durham (United Kingdom)); Roberts, R.G. (Rutherford Appleton Lab., Chilton (United Kingdom))

    1991-08-22

    Precision measurements of {Lambda}sub(anti Manti S) from deep inelastic Scattering traditionally use a fixed renormalization scale {mu} = Q. This is in contrast to measurements in e{sup +}e{sup -} annihilation, where 'scale dependence' is an important source of uncertainty on the value of {Lambda}sub(anti Manti S). We extend our previous determination of {Lambda}sub(anti Manti S) to allow for different scale choices. We find that our previous value of {alpha}{sub s} (M{sub z})=0.109{sub -=.005}{sup +0.004} becomes {alpha}{sub s} (M{sub z})=0.109{sub 00.008}{sup +0.007} when a reasonable variation of scale is included. We discuss the implications of this result for recent attempts to obtain information on the scale of supersymmetry from coupling constant unification. (orig.).

  18. Characterization of a lymphoblastoid line deleted for lambda immunoglobulin genes

    Energy Technology Data Exchange (ETDEWEB)

    Hough, C.A., White, B.N., Holden, J.A. [Queen`s Univ., Ontario (Canada)

    1995-04-01

    While characterizing the cat eye syndrome (CES) supernumerary chromosome for the presence of {lambda} immunoglobulin gene region sequences, a lymphoblastoid cell line from one CES patient was identified in which there was selection of cells deleted from some IGLC and IGLV genes. Two distinct deletions, one on each chromosome 22, were identified, presumably arising from independent somatic recombination events occurring during B-lymphocyte differentiation. The extent of the deleted regions was determined using probes from the various IGLV subgroups and they each covered at least 82 kilobases. The precise definition of the deletions was not possible because of conservation of some restriction sites in the IGLV region. The cell line was used to map putative IGLV genes within the recombinant phage {lambda}V{lambda}135 to the distal part of the IGLV gene region. 35 refs., 4 figs.

  19. LOCAL MEASUREMENT OF {Lambda} USING PULSAR TIMING ARRAYS

    Energy Technology Data Exchange (ETDEWEB)

    Espriu, Domenec; Puigdomenech, Daniel [Departament d' Estructura i Constituents de la Materia and Institut de Ciencies del Cosmos (ICCUB), Universitat de Barcelona, Marti i Franques 1, E-08028 Barcelona (Spain)

    2013-02-20

    We consider the propagation of gravitational waves (GWs) in de Sitter spacetime and how a non-zero value of the cosmological constant might affect their detection in pulsar timing arrays (PTAs). If {Lambda} {ne} 0, the waves are anharmonic in Friedmann-Robertson-Walker coordinates, and although this effect is very small it gives rise to noticeable consequences for GWs originating in extragalactic sources such as spiraling black hole binaries. The results indicate that the timing residuals induced by GWs from such sources in PTAs will show a peculiar angular dependence with a marked enhancement around a particular value of the angle subtended by the source and the pulsars, depending mainly on the actual value of the cosmological constant and the distance to the source. The position of the peak could represent a gauge of the value of {Lambda}. The enhancement that the new effect brings about could facilitate the first direct detection of GWs while representing a local measurement of {Lambda}.

  20. On the role of Cro in lambda prophage induction

    OpenAIRE

    Svenningsen, Sine Lo; Constantino, Nina; Court, Donald L.; Adhya, Sankar

    2005-01-01

    Udgivelsesdato: March 22 The lysogenic state of bacteriophage ¿ is exceptionally stable yet the prophage is readily induced in response to DNA damage. This delicate epigenetic switch is believed to be regulated by two proteins; the lysogenic maintenance promoting protein CI and the early lytic protein Cro. First, we confirm, in the native configuration, the previous observation that the DNA loop mediated by oligomerization of CI bound to two distinct operator regions (O L and O R), increas...

  1. Polarization of Lambda and Anti-Lambda in 920 GeV Fixed-Target Proton-Nucleus Collisions

    CERN Document Server

    Abt, I; Agari, M; Albrecht, H; Aleksandrov, A; Amaral, V S; Amorim, A; Aplin, S J; Aushev, V; Bagaturia, Yu S; Balagura, V; Bargiotti, M; Barsukova, O; Bastos, J; Batista, J; Bauer, C; Bauer, T S; Belkov, A; Belkov, Ar; Belotelov, I; Bertin, A; Bobchenko, B M; Böcker, M; Bogatyrev, A; Böhm, G; Brauer, M; Bruinsma, M; Bruschi, M; Buchholz, P; Buran, T; Carvalho, J; Conde, P; Cruse, C; Dam, M; Danielsen, K M; Danilov, M; De Castro, S; Deppe, H; Dong, X; Dreis, H B; Egorytchev, V; Ehret, K; Eisele, F; Emeliyanov, D; Erhan, S; Essenov, S; Fabbri, L; Faccioli, P; Feuerstack-Raible, M; Flammer, J; Fominykh, B A; Funcke, M; Garrido, L; Gellrich, A; Giacobbe, B; Glass, J; Goloubkov, D; Golubkov, Y; Golutvin, A; Golutvin, I A; Gorbounov, I; Gorisek, A; Gouchtchine, O; Goulart, D C; Gradl, S; Gradl, W; Grimaldi, F; Guilitsky, Yu; Hansen, J D; Hernández, J M; Hofmann, W; Hohlmann, M; Hott, T; Hulsbergen, W; Husemann, U; Igonkina, O; Ispiryan, M; Jagla, T; Jiang, C; Kapitza, H; Karabekyan, S; Karpenko, N; Keller, S; Kessler, J; Khasanov, F; Kiryushin, Yu T; Kisel, I; Klinkby, E; Knöpfle, K T; Kolanoski, H; Korpar, S; Krauss, C; Kreuzer, P; Krizan, P; Krücker, D; Kupper, S; Kvaratskheliia, T; Lanyov, A; Lau, K; Lewendel, B; Lohse, T; Lomonosov, B N; Männer, R; Mankel, R; Masciocchi, S; Massa, I; Matchikhilian, I; Medin, G; Medinnis, M; Mevius, M; Michetti, A; Mikhailov, Yu; Mizuk, R; Muresan, R; Zur Nedden, M; Negodaev, M; Nörenberg, M; Nowak, S; Núñez-Pardo de Vera, M T; Ouchrif, M; Ould-Saada, F; Padilla, C; Peralta, D; Pernack, R; Pestotnik, R; Petersen, B AA; Piccinini, M; Pleier, M A; Poli, M; Popov, V; Pose, D; Prystupa, S; Pugatch, V; Pylypchenko, Y; Pyrlik, J; Reeves, K; Ressing, D; Rick, H; Riu, I; Robmann, P; Rostovtseva, I; Rybnikov, V; Sánchez, F; Sbrizzi, A; Schmelling, M; Schmidt, B; Schreiner, A; Schröder, H; Schwanke, U; Schwartz, A J; Schwarz, A S; Schwenninger, B; Schwingenheuer, B; Sciacca, F; Semprini-Cesari, N; Shuvalov, S; Silva, L; Sozuer, L; Solunin, S; Somov, A; Somov, S; Spengler, J; Spighi, R; Spiridonov, A A; Stanovnik, A; Staric, M; Stegmann, C; Subramanian, H S; Symalla, M; Tikhomirov, I; Titov, M; Tsakov, I; Uwer, U; Van Eldik, C; Vasilev, Yu; Villa, M; Vitale, A; Vukotic, I; Wahlberg, H; Walenta, Albert H; Walter, M; Wang, J J; Wegener, D; Werthenbach, U; Wolters, H; Wurth, R; Wurz, A; Zaitsev, Yu; Zavertyaev, M V; Zeuner, T; Zhelezov, A; Zheng, Z; Zimmermann, R; Zivko, T; Zoccoli, A

    2006-01-01

    A measurement of the polarization of Lambda and Anti-Lambda baryons produced in pC and pW collisions at sqrt(s)=41.6 GeV has been performed with the HERA-B spectrometer. The measurements cover the kinematic range of 0.6 GeV/c < p_T<1.2 GeV/c in transverse momentum and -0.15Lambda agree with a parametrization of previous measurements which were performed at positive x_F values, where the Lambda polarization is negative. Results of Anti-Lambda polarization measurements are consistent with zero.

  2. Expression of a cloned denV gene of bacteriophage T4 in Escherichia coli

    International Nuclear Information System (INIS)

    A 713-base-pair Hae III fragment from bacteriophage T4 encompassing the denV gene with its preceding promoter has been cloned in a pBR322-derived positive-selection vector and introduced into a variety of DNA repair-deficient uvr and rec and uvr,rec Escherichia coli strains. The denV gene was found to be expressed, probably from its own promoter, causing pyrimidine dimer incision-deficient uvrA, uvrB, uvrC strains to be rescued by the denV gene. A uvrD (DNA helicase II) strain was also complemented, but to a lesser extent. A wild-type strain did not seem to be affected at the UV doses tested. Surprisingly, all recA, recB, and recC strains tested also showed an increased UV resistance, perhaps by reinforcement of the intact uvr system in these strains. Complementation of denV- T4 strains and host-cell reactivation of lambda phage was also observed in denV+ E. coli strains. Equilibrium sedimentation showed that DNA repair synthesis occurred in a UV-irradiated uvrA E. coli strain carrying the cloned denV gene. Southern blotting confirmed earlier results that the denV gene is located at 64 kilobases on the T4 map. Phage T2 (denV-) did not hybridize to a denV-specific probe

  3. Expression of a cloned denV gene of bacteriophage T4 in Escherichia coli

    Energy Technology Data Exchange (ETDEWEB)

    Valerie, K.; Henderson, E.E.; de Riel, J.K.

    1985-07-01

    A 713-base-pair Hae III fragment from bacteriophage T4 encompassing the denV gene with its preceding promoter has been cloned in a pBR322-derived positive-selection vector and introduced into a variety of DNA repair-deficient uvr and rec and uvr,rec Escherichia coli strains. The denV gene was found to be expressed, probably from its own promoter, causing pyrimidine dimer incision-deficient uvrA, uvrB, uvrC strains to be rescued by the denV gene. A uvrD (DNA helicase II) strain was also complemented, but to a lesser extent. A wild-type strain did not seem to be affected at the UV doses tested. Surprisingly, all recA, recB, and recC strains tested also showed an increased UV resistance, perhaps by reinforcement of the intact uvr system in these strains. Complementation of denV- T4 strains and host-cell reactivation of lambda phage was also observed in denV+ E. coli strains. Equilibrium sedimentation showed that DNA repair synthesis occurred in a UV-irradiated uvrA E. coli strain carrying the cloned denV gene. Southern blotting confirmed earlier results that the denV gene is located at 64 kilobases on the T4 map. Phage T2 (denV-) did not hybridize to a denV-specific probe.

  4. Competitive effects of nuclear deformation and density dependence of $\\Lambda\\!N$ interaction

    CERN Document Server

    Isaka, M; Rijken, T h A

    2016-01-01

    Competitive effects of nuclear deformation and density dependence of $\\Lambda\\!N$-interaction in $\\Lambda$ binding energies $B_\\Lambda$ of hypernuclei are studied systematically on the basis of the baryon-baryon interaction model ESC including many-body effects. By using the $\\Lambda\\!N$ G-matrix interaction derived from ESC, we perform microscopic calculations of $B_\\Lambda$ in $\\Lambda$ hypernuclei within the framework of the antisymmetrized molecular dynamics under the averaged-density approximation. The calculated values of $B_\\Lambda$ reproduce experimental data within a few hundred keV in the wide mass regions from 9 to 51. It is found that competitive effects of nuclear deformation and density dependence of $\\Lambda\\!N$-interaction work decisively for fine tuning of $B_\\Lambda$ values.

  5. Measurement of Lambda and Lambda(macro) particles in Au+Au collisions at the square root of S(NN) = 130 GeV.

    Science.gov (United States)

    Adcox, K; Adler, S S; Ajitanand, N N; Akiba, Y; Alexander, J; Aphecetche, L; Arai, Y; Aronson, S H; Averbeck, R; Awes, T C; Barish, K N; Barnes, P D; Barrette, J; Bassalleck, B; Bathe, S; Baublis, V; Bazilevsky, A; Belikov, S; Bellaiche, F G; Belyaev, S T; Bennett, M J; Berdnikov, Y; Botelho, S; Brooks, M L; Brown, D S; Bruner, N; Bucher, D; Buesching, H; Bumazhnov, V; Bunce, G; Burward-Hoy, J; Butsyk, S; Carey, T A; Chand, P; Chang, J; Chang, W C; Chavez, L L; Chernichenko, S; Chi, C Y; Chiba, J; Chiu, M; Choudhury, R K; Christ, T; Chujo, T; Chung, M S; Chung, P; Cianciolo, V; Cole, B A; D'Enterria, D G; David, G; Delagrange, H; Denisov, A; Deshpande, A; Desmond, E J; Dietzsch, O; Dinesh, B V; Drees, A; Durum, A; Dutta, D; Ebisu, K; Efremenko, Y V; el-Chenawi, K; En'yo, H; Esumi, S; Ewell, L; Ferdousi, T; Fields, D E; Fokin, S L; Fraenkel, Z; Franz, A; Frawley, A D; Fung, S-Y; Garpman, S; Ghosh, T K; Glenn, A; Godoi, A L; Goto, Y; Greene, S V; Grosse Perdekamp, M; Gupta, S K; Guryn, W; Gustafsson, H-A; Haggerty, J S; Hamagaki, H; Hansen, A G; Hara, H; Hartouni, E P; Hayano, R; Hayashi, N; He, X; Hemmick, T K; Heuser, J M; Hibino, M; Hill, J C; Ho, D S; Homma, K; Hong, B; Hoover, A; Ichihara, T; Imai, K; Ippolitov, M S; Ishihara, M; Jacak, B V; Jang, W Y; Jia, J; Johnson, B M; Johnson, S C; Joo, K S; Kametani, S; Kang, J H; Kann, M; Kapoor, S S; Kelly, S; Khachaturov, B; Khanzadeev, A; Kikuchi, J; Kim, D J; Kim, H J; Kim, S Y; Kim, Y G; Kinnison, W W; Kistenev, E; Kiyomichi, A; Klein-Boesing, C; Klinksiek, S; Kochenda, L; Kochetkov, V; Koehler, D; Kohama, T; Kotchetkov, D; Kozlov, A; Kroon, P J; Kurita, K; Kweon, M J; Kwon, Y; Kyle, G S; Lacey, R; Lajoie, J G; Lauret, J; Lebedev, A; Lee, D M; Leitch, M J; Li, X H; Li, Z; Lim, D J; Liu, M X; Liu, X; Liu, Z; Maguire, C F; Mahon, J; Makdisi, Y I; Manko, V I; Mao, Y; Mark, S K; Markacs, S; Martinez, G; Marx, M D; Masaike, A; Matathias, F; Matsumoto, T; McGaughey, P L; Melnikov, E; Merschmeyer, M; Messer, F; Messer, M; Miake, Y; Miller, T E; Milov, A; Mioduszewski, S; Mischke, R E; Mishra, G C; Mitchell, J T; Mohanty, A K; Morrison, D P; Moss, J M; Mühlbacher, F; Mukhopadhyay, D; Muniruzzaman, M; Murata, J; Nagamiya, S; Nagasaka, Y; Nagle, J L; Nakada, Y; Nandi, B K; Newby, J; Nikkinen, L; Nilsson, P; Nishimura, S; Nyanin, A S; Nystrand, J; O'Brien, E; Ogilvie, C A; Ohnishi, H; Ojha, I D; Ono, M; Onuchin, V; Oskarsson, A; Osterman, L; Otterlund, I; Oyama, K; Paffrath, L; Pal, D; Palounek, A P T; Pantuev, V S; Papavassiliou, V; Pate, S F; Peitzmann, T; Petridis, A N; Pinkenburg, C; Pisani, R P; Pitukhin, P; Plasil, F; Pollack, M; Pope, K; Purschke, M L; Ravinovich, I; Read, K F; Reygers, K; Riabov, V; Riabov, Y; Rosati, M; Rose, A A; Ryu, S S; Saito, N; Sakaguchi, A; Sakaguchi, T; Sako, H; Sakuma, T; Samsonov, V; Sangster, T C; Santo, R; Sato, H D; Sato, S; Sawada, S; Schlei, B R; Schutz, Y; Semenov, V; Seto, R; Shea, T K; Shein, I; Shibata, T-A; Shigaki, K; Shiina, T; Shin, Y H; Sibiriak, I G; Silvermyr, D; Sim, K S; Simon-Gillo, J; Singh, C P; Singh, V; Sivertz, M; Soldatov, A; Soltz, R A; Sorensen, S; Stankus, P W; Starinsky, N; Steinberg, P; Stenlund, E; Ster, A; Stoll, S P; Sugioka, M; Sugitate, T; Sullivan, J P; Sumi, Y; Sun, Z; Suzuki, M; Takagui, E M; Taketani, A; Tamai, M; Tanaka, K H; Tanaka, Y; Taniguchi, E; Tannenbaum, M J; Thomas, J; Thomas, J H; Thomas, T L; Tian, W; Tojo, J; Torii, H; Towell, R S; Tserruya, I; Tsuruoka, H; Tsvetkov, A A; Tuli, S K; Tydesjö, H; Tyurin, N; Ushiroda, T; Van Hecke, H W; Velissaris, C; Velkovska, J; Velkovsky, M; Vinogradov, A A; Volkov, M A; Vorobyov, A; Vznuzdaev, E; Wang, H; Watanabe, Y; White, S N; Witzig, C; Wohn, F K; Woody, C L; Xie, W; Yagi, K; Yokkaichi, S; Young, G R; Yushmanov, I E; Zajc, W A; Zhang, Z; Zhou, S; Zhou, S

    2002-08-26

    We present results on the measurement of Lambda and Lambda(macro) production in Au+Au collisions at square root of (S (NN) = 130 GeV with the PHENIX detector at the Relativistic Heavy Ion Collider. The transverse momentum spectra were measured for minimum bias and for the 5% most central events. The Lambda;/Lambda ratios are constant as a function of p(T) and the number of participants. The measured net Lambda density is significantly larger than predicted by models based on hadronic strings (e.g., HIJING) but in approximate agreement with models which include the gluon-junction mechanism. PMID:12190391

  6. $\\Lambda$ polarization in peripheral collisions at moderate relativistic energies

    CERN Document Server

    Xie, Y L; Stöcker, H; Wang, D J; Csernai, L P

    2016-01-01

    The polarization of $\\Lambda$ hyperons from relativistic flow vorticity is studied in peripheral heavy ion reactions at FAIR and NICA energies, just above the threshold of the transition to the Quark-Gluon Plasma. Previous calculations at higher energies with larger initial angular momentum, predicted significant $\\Lambda$ polarization based on the classical vorticity term in the polarization, while relativistic modifications decreased the polarization and changed its structure in the momentum space. At the lower energies studied here, we see the same effect namely that the relativistic modifications decrease the polarization arising from the initial shear flow vorticity.

  7. A Strong Constraint on Ever-Present Lambda

    CERN Document Server

    Barrow, J D

    2006-01-01

    We show that the causal set approach to creating an ever-present cosmological 'constant' in the expanding universe is strongly constrained by the isotropy of the microwave background. Fluctuations generated by stochastic lambda generation which are consistent with COBE and WMAP observations are far too small to dominate the expansion dynamics at z<1000 and so cannot explain the observed late-time acceleration of the universe. We also discuss other observational constraints from the power spectrum of galaxy clustering and show that the theoretical possibility of ever-present lambda arises only in 3+1 dimensional space-times.

  8. High Resolution Spectroscopy of 12B_Lambda by Electroproduction

    CERN Document Server

    Iodice, M; Acha, A; Ambrozewicz, P; Aniol, K A; Baturin, P; Bertin, P Y; Benaoum, H; Blomqvist, K I; Böglin, W; Breuer, H; Brindza, P; Bydzovsky, P; Camsonne, A; Chang, C C; Chen, J -P; Choi, Seonho; Chudakov, E A; Cisbani, E; Colilli, S; Coman, L; Craver, B J; DeCataldo, G; deJager, C W; DeLeo, R; Deur, A P; Ferdi, C; Feuerbach, R J; Folts, E; Fratoni, R; Frullani, S; Garibaldi, F; Gayou, O; Giulani, F; Gómez, J; Gricia, M; Hansen, J O; Hayes, D; Higinbotham, D W; Holmstrom, T; Hyde, C E; Ibrahim, H F; Jiang, X; Kaufman, L J; Kino, K; Kross, B; Lagamba, L; LeRose, J J; Lindgren, R A; Lucentini, M; Margaziotis, D J; Markowitz, P; Marrone, S; Meziani, Z E; McCormick, K; Michaels, R W; Millener, D J; Miyoshi, T; Moffit, B; Monaghan, P A; Moteabbed, M; MunozCamacho, C; Nanda, S; Nappi, E; Nelyubin, V V; Norum, B E; Okasyasu, Y; Paschke, K D; Perdrisat, C F; Piasetzky, E; Punjabi, V A; Qiang, Y; Raue, B; Reimer, P E; Reinhold, J; Reitz, B; Roche, R E; Rodriguez, V M; Saha, A; Santavenere, F; Sarty, A J; Segal, J; Shahinyan, A; Singh, J; Sirca, S; Snyder, R; Solvignon, P H; Sotona, M; Subedi, R; Sulkosky, V A; Suzuki, T; Ueno, H; Ulmer, P E; Urciuoli, G M; Veneroni, P; Voutier, E; Wojtsekhowski, B B; Zheng, X; Zorn, C

    2007-01-01

    An experiment measuring electroproduction of hypernuclei has been performed in Hall A at Jefferson Lab on a $^{12}$C target. In order to increase counting rates and provide unambiguous kaon identification two superconducting septum magnets and a Ring Imaging CHerenkov detector (RICH) were added to the Hall A standard equipment. An unprecedented energy resolution of less than 700 keV FWHM has been achieved. Thus, the observed \\lam{12}{B} spectrum shows for the first time identifiable strength in the core-excited region between the ground-state {\\it s}-wave $\\Lambda$ peak and the 11 MeV {\\it p}-wave $\\Lambda$ peak.

  9. High Resolution Spectroscopy of 12B_Lambda by Electroproduction

    Energy Technology Data Exchange (ETDEWEB)

    M. Iodice; F. Cusanno; A. Acha; P. Ambrozewicz; K.A. Aniol; P. Baturin; P.Y. Bertin; H. Benaoum; K.I. Blomqvist; W.U. Boeglin; H. Breuer; P. Brindza; P. Bydˇzovsk´y; A. Camsonne; C.C. Chang; J.-P. Chen; Seonho Choi; E.A. Chudakov; E. Cisbani; S. Colilli; L. Coman; B.J. Craver; G. De Cataldo; C.W. de Jager; R. De Leo; A.P. Deur; C. Ferdi; R.J. Feuerbach; E. Folts; R. Fratoni; S. Frullani; F. Garibaldi; O. Gayou; F. Giulani; J. Gomez; M. Gricia; J.O. Hansen; D. Hayes; D.W. Higinbotham; T.K. Holmstrom; C.E. Hyde; ; H.F. Ibrahim; X. Jiang; L.J. Kaufman; K. Kino; B. Kross; L. Lagamba; J.J. LeRose; R.A. Lindgren; M. Lucentini; D.J. Margaziotis; P. Markowitz; S. Marrone; Z.E. Meziani; K. McCormick; R.W. Michaels; D.J. Millener; T. Miyoshi; B. Moffit; P.A. Monaghan; M. Moteabbed; C. Munoz Camacho; S. Nanda; E. Nappi; V.V. Nelyubin; B.E. Norum; Y. Okasyasu; K.D. Paschke; C.F. Perdrisat; E. Piasetzky; V.A. Punjabi; Y. Qiang; B. Raue; P.E. Reimer; J. Reinhold; B. Reitz; R.E. Roche; V.M. Rodriguez; A. Saha; F. Santavenere; A.J. Sarty; J. Segal; A. Shahinyan; J. Singh; S. ˇ Sirca; R. Snyder; P.H. Solvignon; M. Sotona; R. Subedi; V.A. Sulkosky; T. Suzuki; H. Ueno; P.E. Ulmer; G.M. Urciuoli; P. Veneroni; E. Voutier; B.B. Wojtsekhowski; X. Zheng; and C. Zorn

    2007-07-01

    An experiment measuring electroproduction of hypernuclei has been performed in Hall A at Jefferson Lab on a $^{12}$C target. In order to increase counting rates and provide unambiguous kaon identification two superconducting septum magnets and a Ring Imaging CHerenkov detector (RICH) were added to the Hall A standard equipment. An unprecedented energy resolution of less than 700 keV FWHM has been achieved. Thus, the observed \\lam{12}{B} spectrum shows for the first time identifiable strength in the core-excited region between the ground-state {\\it s}-wave $\\Lambda$ peak and the 11 MeV {\\it p}-wave $\\Lambda$ peak.

  10. Exploring The Lambda Model Of The Hybrid Superstring

    CERN Document Server

    Schmidtt, David M

    2016-01-01

    The purpose of this contribution is to initiate the study of integrable deformations for different superstring theory formalisms that manifest the property of (classical) integrability. In this paper we choose the hybrid formalism of the superstring in the background AdS_{2}xS^{2} and explore in detail the most immediate consequences of its lambda-deformation. The resulting action functional corresponds to the lambda-model of the matter part of the fairly more sophisticated pure spinor formalism, which is also known to be classical integrable. In particular, the deformation preserves the integrability and the one-loop conformal invariance of its parent theory, hence being a marginal deformation.

  11. A lattice determination of Sigma-Lambda mixing

    Energy Technology Data Exchange (ETDEWEB)

    Horsley, R. [Edinburgh Univ. (United Kingdom). School of Physics and Astronomy; Najjar, J. [Regensburg Univ. (Germany). Institut fuer Theoretische Physik; Nakamura, Y. [RIKEN Advanced Institute for Computational Science, Kobe (Japan); Perlt, H.; Schiller, A. [Leipzig Univ. (Germany). Inst. fuer Theoretische Physik; Pleiter, D. [Forschungszentrum Juelich (Germany). Juelich Supercomputer Centre; Rakow, P.E.L. [Liverpool Univ. (United Kingdom). Theoretical Physics Division; Schierholz, G. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Stueben, H. [Hamburg Univ. (Germany). Regionales Rechenzentrum; Zanotti, J.M. [Adelaide Univ. (Australia). CSSM, Dept. of Physics; Collaboration: QCDSF-UKQCD Collaboration

    2014-11-15

    Isospin breaking effects in baryon octet (and decuplet) masses are due to a combination of up and down quark mass differences and electromagnetic effects and lead to small mass splittings. Between the Sigma and Lambda this mass splitting is much larger, this being mostly due to their different wavefunctions. However when isospin is broken, there is a mixing between between these states. We describe the formalism necessary to determine the QCD mixing matrix and hence find the mixing angle and mass splitting between the Sigma and Lambda particles due to QCD effects.

  12. Bacteriophages as Bactericides in Plant Protection

    Directory of Open Access Journals (Sweden)

    Aleksa Obradović

    2009-01-01

    Full Text Available Control of plant pathogenic bacteria is a serious problem in production of many agricultural crops. High multiplication rate, adaptability and life inside plant tissue make bacteria unsuitable and inaccessible for most of control measures. Consequently, the list of bactericides available for plant protection is very short. Lately, biological control measures have been intensively studied as a potential solution of the problem. Investigation of bacteriophages,viruses that attack bacteria, is a fast-expanding area of research in plant protection. Several experiments have shown that they can be used as a very efficient tool for control of plant pathogenic bacteria. The fact that they are widespread natural bacterial enemies, simple for cultivation and management, host-specific, suitable for integration with other control practices, human and environment friendly, provide a great advantage for the application of phages over other bactericides.

  13. Bacteriophage T7 DNA polymerase — Sequenase

    Directory of Open Access Journals (Sweden)

    Bin eZhu

    2014-04-01

    Full Text Available An ideal DNA polymerase for chain-terminating DNA sequencing should possess the following features: 1 incorporate dideoxy- and other modified nucleotides at an efficiency similar to that of the cognate deoxynucleotides; 2 high processivity; 3 high fidelity in the absence of proofreading/exonuclease activity; and 4 production of clear and uniform signals for detection. The DNA polymerase encoded by bacteriophage T7 is naturally endowed with or can be engineered to have all these characteristics. The chemically or genetically modified enzyme (Sequenase expedited significantly the development of DNA sequencing technology. This article reviews the history of studies on T7 DNA polymerase with emphasis on the serial key steps leading to its use in DNA sequencing. Lessons from the study and development of T7 DNA polymerase have and will continue to enlighten the characterization of novel DNA polymerases from newly discovered microbes and their modification for use in biotechnology.

  14. Bacteriophage endolysins: applications for food safety.

    Science.gov (United States)

    Schmelcher, Mathias; Loessner, Martin J

    2016-02-01

    Bacteriophage endolysins (peptidoglycan hydrolases) have emerged as a new class of antimicrobial agents useful for controlling bacterial infection or other unwanted contaminations in various fields, particularly in the light of the worldwide increasing frequency of drug-resistant pathogens. This review summarizes and discusses recent developments regarding the use of endolysins for food safety. Besides the use of native and engineered endolysins for controlling bacterial contamination at different points within the food production chain, this also includes the application of high-affinity endolysin-derived cell wall binding domains for rapid detection of pathogenic bacteria. Novel approaches to extend the lytic action of endolysins towards Gram-negative cells will also be highlighted.

  15. Why Be Temperate: Lessons from Bacteriophage λ.

    Science.gov (United States)

    Gandon, Sylvain

    2016-05-01

    Many pathogens have evolved the ability to induce latent infections of their hosts. The bacteriophage λ is a classical model for exploring the regulation and the evolution of latency. Here, I review recent experimental studies on phage λ that identify specific conditions promoting the evolution of lysogenic life cycles. In addition, I present specific adaptations of phage λ that allow this virus to react plastically to variations in the environment and to reactivate its lytic life cycle. All of these different examples are discussed in the light of evolutionary epidemiology theory to disentangle the different evolutionary forces acting on temperate phages. Understanding phage λ adaptations yield important insights into the evolution of latency in other microbes, including several life-threatening human pathogens. PMID:26946976

  16. Bacteriophages of Leuconostoc, Oenococcus and Weissella

    Directory of Open Access Journals (Sweden)

    Witold P. Kot

    2014-04-01

    Full Text Available Leuconostoc (Ln., Weissella and Oenococcus form a group of related genera of lactic acid bacteria, which once all shared the name Leuconostoc. They are associated with plants, fermented vegetable products, raw milk, dairy products, meat and fish. Most of industrially relevant Leuconostoc strains can be classified as either Ln. mesenteroides or Ln. pseudomesenteroides. They are important flavor producers in dairy fermentations and they initiate nearly all vegetable fermentations. Therefore bacteriophages attacking Leuconostoc strains may negatively influence the production process. Bacteriophages attacking Leuconostoc strains were first reported in 1946. Since then, the majority of described Leuconostoc phages was isolated from either dairy products or fermented vegetable products. Both lytic and temperate phages of Leuconostoc were reported. Most of Leuconostoc phages examined using electron microscopy belong to the Siphoviridae family and differ in morphological details. Hybridization and comparative genomic studies of Leuconostoc phages suggest that they can be divided into several groups, however overall diversity of Leuconostoc phages is much lower as compared to e.g. lactococcal phages. Several fully sequenced genomes of Leuconostoc phages have been deposited in public databases. Lytic phages of Leuconostoc can be divided into two host species-specific groups with similarly organized genomes that shared very low nucleotide similarity. Phages of dairy Leuconostoc have rather limited host-ranges. The receptor binding proteins of two lytic Ln. pseudomesenteroides phages have been identified. Molecular tools for detection of dairy Leuconostoc phages have been developed. The rather limited data on phages of Oenococcus and Weissella show that i lysogeny seems to be abundant in Oenococcus strains, and ii several phages infecting Weissella cibaria are also able to productively infect strains of other Weissella species and even strains of the genus

  17. Montmorillonite-induced Bacteriophage φ6 Disassembly

    Science.gov (United States)

    Trusiak, A.; Gottlieb, P.; Katz, A.; Alimova, A.; Steiner, J. C.; Block, K. A.

    2012-12-01

    It is estimated that there are 1031 virus particles on Earth making viruses an order of magnitude more prevalent in number than prokaryotes with the vast majority of viruses being bacteriophages. Clays are a major component of soils and aquatic sediments and can react with RNA, proteins and bacterial biofilms. The clays in soils serve as an important moderator between phage and their host bacteria, helping to preserve the evolutionary balance. Studies on the effects of clays on viral infectivity have given somewhat contradictory results; possibly a consequence of clay-virus interactions being dependent on the unique structure of particular viruses. In this work, the interaction between montmorillonite and the bacteriophage φ6 is investigated. φ6 is a member of the cystovirus family that infects Pseudomonas syringe, a common plant pathogen. As a member of the cystovirus family with an enveloped structure, φ6 serves as a model for reoviruses, a human pathogen. Experiments were conducted with φ6 suspended in dilute, purified homoionic commercial-grade montmorillonite over a range of virus:clay ratios. At a 1:100000 virus:clay ratio, the clay reduced viral infectivity by 99%. The minimum clay to virus ratio which results in a measurable reduction of P. syringae infection is 1:1. Electron microscopy demonstrates that mixed suspensions of smectite and virus co-aggregate to form flocs encompassing virions within the smectite. Both free viral particles as well as those imbedded in the flocs are seen in the micrographs to be missing the envelope- leaving only the nucleocapsid (NC) intact; indicating that smectite inactivates the virus by envelope disassembly. These results have strong implications in the evolution of both the φ6 virus and its P. syringae host cells. TEM of aggregate showing several disassembled NCs.

  18. A Hypothesis for Bacteriophage DNA Packaging Motors

    Directory of Open Access Journals (Sweden)

    Philip Serwer

    2010-08-01

    Full Text Available The hypothesis is presented that bacteriophage DNA packaging motors have a cycle comprised of bind/release thermal ratcheting with release-associated DNA pushing via ATP-dependent protein folding. The proposed protein folding occurs in crystallographically observed peptide segments that project into an axial channel of a protein 12-mer (connector that serves, together with a coaxial ATPase multimer, as the entry portal. The proposed cycle begins when reverse thermal motion causes the connector’s peptide segments to signal the ATPase multimer to bind both ATP and the DNA molecule, thereby producing a dwell phase recently demonstrated by single-molecule procedures. The connector-associated peptide segments activate by transfer of energy from ATP during the dwell. The proposed function of connector/ATPase symmetry mismatches is to reduce thermal noise-induced signaling errors. After a dwell, ATP is cleaved and the DNA molecule released. The activated peptide segments push the released DNA molecule, thereby producing a burst phase recently shown to consist of four mini-bursts. The constraint of four mini-bursts is met by proposing that each mini-burst occurs via pushing by three of the 12 subunits of the connector. If all four mini-bursts occur, the cycle repeats. If the mini-bursts are not completed, a second cycle is superimposed on the first cycle. The existence of the second cycle is based on data recently obtained with bacteriophage T3. When both cycles stall, energy is diverted to expose the DNA molecule to maturation cleavage.

  19. Observation of. lambda. -hypernuclei in the reaction /sup 12/C(. pi. /sup +/,K/sup +/)/sub. lambda. //sup 12/C

    Energy Technology Data Exchange (ETDEWEB)

    Milner, E.C.

    1985-12-01

    The observation of ..lambda..-hypernuclear levels in /sub ..lambda..//sup 12/C by associated production through the (..pi../sup +/,K/sup +/) reaction is reported. Spectrometers used in the measurements are discussed. The /sub ..lambda..//sup 12/C excitation energy spectra were recorded at laboratory scattering angles of 5.6/sup 0/, 10.3/sup 0/, and 15.2/sup 0/. The spectra show two major peaks - one attributed to the ground state, and one about 11 MeV higher in excitation. The peak near 11 MeV excitation energy is believed to be almost entirely composed of a multiplet of three J/sup ..pi../ = 2/sup +/ states. Relativistic DWBA calculations imply support for the expectation that higher spin states are preferentially populated in the (..pi../sup +/,K/sup +/) reaction, compared to the (K/sup -/,..pi../sup -/) reaction in which lower spin states are excited. 29 refs., 40 figs.

  20. Calculation of 1/m^{2}_{b} corrections to {\\Lambda}_b\\rightarrow{\\Lambda}_c decay widths in the Bethe-Salpeter equation approach

    CERN Document Server

    Zhang, L; Weng, M -H

    2016-01-01

    The matrix element of the weak transition {\\Lambda}_b\\rightarrow{\\Lambda}_c can be expressed in terms of six form factors. {\\Lambda}_Q(Q = b;c) can be regarded as composed of a heavy quark Q(Q = b;c) and a diquark which is made up of the remaining two light quarks. In this picture, we express these six form factors in terms of Bethe-Salpeter wave functions to second order in the 1/m_Q expansion. With the kernel containing both the scalar confinement and the one-gluon-exchange terms we calculate the form factors and the decay widths of the semileptonic decay {\\Lambda}_b\\rightarrow{\\Lambda}_clv as well as nonleptonic decays {\\Lambda}_b\\rightarrow{\\Lambda}_cP(V) numerically. We also add QCD corrections since they are comparable with 1/m_Q corrections.

  1. Identification of a panel of tumor-associated antigens from breast carcinoma cell lines, solid tumors and testis cDNA libraries displayed on lambda phage

    Directory of Open Access Journals (Sweden)

    Cianfriglia Maurizio

    2004-11-01

    Full Text Available Abstract Background Tumor-associated antigens recognized by humoral effectors of the immune system are a very attractive target for human cancer diagnostics and therapy. Recent advances in molecular techniques have led to molecular definition of immunogenic tumor proteins based on their reactivity with autologous patient sera (SEREX. Methods Several high complexity phage-displayed cDNA libraries from breast carcinomas, human testis and breast carcinoma cell lines MCF-7, MDA-MB-468 were constructed. The cDNAs were expressed in the libraries as fusion to bacteriophage lambda protein D. Lambda-displayed libraries were efficiently screened with sera from patients with breast cancer. Results A panel of 21 clones representing 18 different antigens, including eight proteins of unknown function, was identified. Three of these antigens (T7-1, T11-3 and T11-9 were found to be overexpressed in tumors as compared to normal breast. A serological analysis of the 21 different antigens revealed a strong cancer-related profile for at least five clones (T6-2, T6-7, T7-1, T9-21 and T9-27. Conclusions Preliminary results indicate that patient serum reactivity against five of the antigens is associated with tumor disease. The novel T7-1 antigen, which is overexpressed in breast tumors and recognized specifically by breast cancer patient sera, is potentially useful in cancer diagnosis.

  2. Lambda flow in heavy-ion collisions: the role of final-state interactions

    OpenAIRE

    Li, G. Q.; Ko, C. M.

    1996-01-01

    Lambda flow in Ni+Ni collisions at SIS energies is studied in the relativistic transport model (RVUU 1.0). It is found that for primordial lambdas the flow is considerably weaker than proton flow. The inclusion of final-state interactions, especially the propagation of lambdas in mean-field potential, brings the lambda flow close to that of protons. An accurate determination of lambda flow in heavy-ion experiments is shown to be very useful for studying lambda properties in dense matter.

  3. Lepton polarization effects in "Lambda_b -> Lambda l+l-" decay in family non-universal Z' model

    OpenAIRE

    T. M. Aliev; Savci, M.

    2012-01-01

    Possible manifestation of the family non-universal Z' boson effects in lepton polarization in rare, exclusive baryonic "Lambda_b -> Lambda l+l-" decay is examined. It is observed that the double lepton polarizations P_TT and P_NN are sensitive to the Z' contribution. Moreover, it is found that the zero position of the polarized forward-backward asymmetry A_FB^LL is shifted to the left compared to the standard model prediction. Therefore, determination of the zero value of A_FB^LL is quite an ...

  4. Octamerization of lambda CI repressor is needed for effective repression of P(RM) and efficient switching from lysogeny.

    Science.gov (United States)

    Dodd, I B; Perkins, A J; Tsemitsidis, D; Egan, J B

    2001-11-15

    The CI repressor of bacteriophage lambda is a model for the role of cooperativity in the efficient functioning of genetic switches. Pairs of CI dimers interact to cooperatively occupy adjacent operator sites at O(R) and at O(L). These CI tetramers repress the lytic promoters and activate transcription of the cI gene from P(RM). CI is also able to octamerize, forming a large DNA loop between O(R) and O(L), but the physiological role of this is unclear. Another puzzle is that, although a dimer of CI is able to repress P(RM) by binding to the third operator at O(R), O(R)3, this binding seems too weak to affect CI production in the lysogenic state. Here we show that repression of P(RM) at lysogenic CI concentrations is absolutely dependent on O(L), in this case 3.8 kb away. A mutant defective in this CI negative autoregulation forms a lysogen with elevated CI levels that cannot efficiently switch from lysogeny to lytic development. Our results invalidate previous evidence that Cro binding to O(R)3 is important in prophage induction. We propose the octameric CI:O(R)-O(L) complex increases the affinity of CI for O(R)3 by allowing a CI tetramer to link O(R)3 and the third operator at O(L), O(L)3. PMID:11711436

  5. Determination of Lambda in quenched and full QCD - an update

    International Nuclear Information System (INIS)

    We present an update on our previous determination of the Lambda parameter in QCD. The main emphasis is on results for two flavours of light dynamical quarks, where we can now almost double the amount of data used, including values at smaller lattice spacings. The calculations are performed using O(a) improved Wilson fermions. Little change is found to previous numerical values

  6. Resonances in Lambda_c+ to p K- pi+

    CERN Document Server

    Medellin, Z J; Morelos, A; Engelfried, Jurgen; Morelos, Antonio

    2002-01-01

    We report very preliminary results of a Dalitz-plot analysis of Lambda_c+ in the decay to p K- pi+ with the helicity formalism. We used the data from the fixed target experiment SELEX (E781) in Fermilab. We report about branching-ratios of the resonant states involved, and a possible initial state polarization.

  7. The Local Void: for or against $\\Lambda$CDM?

    CERN Document Server

    Xie, Lizhi; Guo, Qi

    2014-01-01

    The emptiness of the Local Void has been put forward as a serious challenge to the current standard paradigm of structure formation in $\\Lambda$CDM. We use a high resolution cosmological N-body simulation, the Millennium-II run, combined with a sophisticated semi-analytical galaxy formation model, to explore statistically whether the local void is allowed within our current knowledge of galaxy formation in $\\Lambda$CDM. We find that about $15$ percent of the Local Group analogue systems ($11$ of $77$) in our simulation are associated with nearby low density regions having size and 'emptiness' similar to those of the observed Local Void. This suggests that, rather than a crisis of the $\\Lambda$CDM, the emptiness of the Local Void is indeed a success of the standard $\\Lambda$CDM theory. The paucity of faint galaxies in such voids results from a combination of two factors: a lower amplitude of the halo mass function in the voids than in the field, and a lower galaxy formation efficiency in void haloes due to hal...

  8. Precision measurement of the $\\Lambda_b^0$ baryon lifetime

    CERN Document Server

    Aaij, R; Adinolfi, M; Adrover, C; Affolder, A; Ajaltouni, Z; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves Jr, A A; Amato, S; Amerio, S; Amhis, Y; Anderlini, L; Anderson, J; Andreassen, R; Andrews, J E; Appleby, R B; Aquines Gutierrez, O; Archilli, F; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Baalouch, M; Bachmann, S; Back, J J; Baesso, C; Balagura, V; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Bauer, Th; Bay, A; Beddow, J; Bedeschi, F; Bediaga, I; Belogurov, S; Belous, K; Belyaev, I; Ben-Haim, E; Bencivenni, G; Benson, S; Benton, J; Berezhnoy, A; Bernet, R; Bettler, M -O; van Beuzekom, M; Bien, A; Bifani, S; Bird, T; Bizzeti, A; Bjørnstad, P M; Blake, T; Blanc, F; Blouw, J; Blusk, S; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borghi, S; Borgia, A; Bowcock, T J V; Bowen, E; Bozzi, C; Brambach, T; van den Brand, J; Bressieux, J; Brett, D; Britsch, M; Britton, T; Brook, N H; Brown, H; Burducea, I; Bursche, A; Busetto, G; Buytaert, J; Cadeddu, S; Callot, O; Calvi, M; Calvo Gomez, M; Camboni, A; Campana, P; Campora Perez, D; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carranza-Mejia, H; Carson, L; Carvalho Akiba, K; Casse, G; Castillo Garcia, L; Cattaneo, M; Cauet, Ch; Cenci, R; Charles, M; Charpentier, Ph; Chen, P; Chiapolini, N; Chrzaszcz, M; Ciba, K; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coca, C; Coco, V; Cogan, J; Cogneras, E; Collins, P; Comerma-Montells, A; Contu, A; Cook, A; Coombes, M; Coquereau, S; Corti, G; Couturier, B; Cowan, G A; Craik, D C; Cunliffe, S; Currie, R; D'Ambrosio, C; David, P; David, P N Y; Davis, A; De Bonis, I; De Bruyn, K; De Capua, S; De Cian, M; De Miranda, J M; De Paula, L; De Silva, W; De Simone, P; Decamp, D; Deckenhoff, M; Del Buono, L; Déléage, N; Derkach, D; Deschamps, O; Dettori, F; Di Canto, A; Dijkstra, H; Dogaru, M; Donleavy, S; Dordei, F; Dosil Suárez, A; Dossett, D; Dovbnya, A; Dupertuis, F; Durante, P; Dzhelyadin, R; Dziurda, A; Dzyuba, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; van Eijk, D; Eisenhardt, S; Eitschberger, U; Ekelhof, R; Eklund, L; El Rifai, I; Elsasser, Ch; Falabella, A; Färber, C; Fardell, G; Farinelli, C; Farry, S; Ferguson, D; Fernandez Albor, V; Ferreira Rodrigues, F; Ferro-Luzzi, M; Filippov, S; Fiore, M; Fitzpatrick, C; Fontana, M; Fontanelli, F; Forty, R; Francisco, O; Frank, M; Frei, C; Frosini, M; Furcas, S; Furfaro, E; Gallas Torreira, A; Galli, D; Gandelman, M; Gandini, P; Gao, Y; Garofoli, J; Garosi, P; Garra Tico, J; Garrido, L; Gaspar, C; Gauld, R; Gersabeck, E; Gersabeck, M; Gershon, T; Ghez, Ph; Gibson, V; Giubega, L; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gorbounov, P; Gordon, H; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graziani, G; Grecu, A; Greening, E; Gregson, S; Griffith, P; Grünberg, O; Gui, B; Gushchin, E; Guz, Yu; Gys, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hall, S; Hamilton, B; Hampson, T; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; Hartmann, T; He, J; Head, T; Heijne, V; Hennessy, K; Henrard, P; Hernando Morata, J A; van Herwijnen, E; Hicheur, A; Hicks, E; Hill, D; Hoballah, M; Hombach, C; Hopchev, P; Hulsbergen, W; Hunt, P; Huse, T; Hussain, N; Hutchcroft, D; Hynds, D; Iakovenko, V; Idzik, M; Ilten, P; Jacobsson, R; Jaeger, A; Jans, E; Jaton, P; Jawahery, A; Jing, F; John, M; Johnson, D; Jones, C R; Joram, C; Jost, B; Kaballo, M; Kandybei, S; Kanso, W; Karacson, M; Karbach, T M; Kenyon, I R; Ketel, T; Keune, A; Khanji, B; Kochebina, O; Komarov, I; Koopman, R F; Koppenburg, P; Korolev, M; Kozlinskiy, A; Kravchuk, L; Kreplin, K; Kreps, M; Krocker, G; Krokovny, P; Kruse, F; Kucharczyk, M; Kudryavtsev, V; Kvaratskheliya, T; La Thi, V N; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lambert, R W; Lanciotti, E; Lanfranchi, G; Langenbruch, C; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J -P; Lefèvre, R; Leflat, A; Lefrançois, J; Leo, S; Leroy, O; Lesiak, T; Leverington, B; Li, Y; Li Gioi, L; Liles, M; Lindner, R; Linn, C; Liu, B; Liu, G; Lohn, S; Longstaff, I; Lopes, J H; Lopez-March, N; Lu, H; Lucchesi, D; Luisier, J; Luo, H; Machefert, F; Machikhiliyan, I V; Maciuc, F; Maev, O; Malde, S; Manca, G; Mancinelli, G; Maratas, J; Marconi, U; Marino, P; Märki, R; Marks, J; Martellotti, G; Martens, A; Martín Sánchez, A; Martinelli, M; Martinez Santos, D; Martins Tostes, D; Massafferri, A; Matev, R; Mathe, Z; Matteuzzi, C; Maurice, E; Mazurov, A; Mc Skelly, B; McCarthy, J; McNab, A; McNulty, R; Meadows, B; Meier, F; Meissner, M; Merk, M; Milanes, D A; Minard, M -N; Molina Rodriguez, J; Monteil, S; Moran, D; Morawski, P; Mordà, A; Morello, M J; Mountain, R; Mous, I; Muheim, F; Müller, K; Muresan, R; Muryn, B; Muster, B; Naik, P; Nakada, T; Nandakumar, R; Nasteva, I; Needham, M; Neubert, S; Neufeld, N; Nguyen, A D; Nguyen, T D; Nguyen-Mau, C; Nicol, M; Niess, V; Niet, R; Nikitin, N; Nikodem, T; Nomerotski, A; Novoselov, A; Oblakowska-Mucha, A; Obraztsov, V; Oggero, S; Ogilvy, S; Okhrimenko, O; Oldeman, R; Orlandea, M; Otalora Goicochea, J M; Owen, P; Oyanguren, A; Pal, B K; Palano, A; Palczewski, T; Palutan, M; Panman, J; Papanestis, A; Pappagallo, M; Parkes, C; Parkinson, C J; Passaleva, G; Patel, G D; Patel, M; Patrick, G N; Patrignani, C; Pavel-Nicorescu, C; Pazos Alvarez, A; Pellegrino, A; Penso, G; Pepe Altarelli, M; Perazzini, S; Perez Trigo, E; Pérez-Calero Yzquierdo, A; Perret, P; Perrin-Terrin, M; Pescatore, L; Pesen, E; Pessina, G; Petridis, K; Petrolini, A; Phan, A; Picatoste Olloqui, E; Pietrzyk, B; Pilař, T; Pinci, D; Playfer, S; Plo Casasus, M; Polci, F; Polok, G; Poluektov, A; Polycarpo, E; Popov, A; Popov, D; Popovici, B; Potterat, C; Powell, A; Prisciandaro, J; Pritchard, A; Prouve, C; Pugatch, V; Puig Navarro, A; Punzi, G; Qian, W; Rademacker, J H; Rakotomiaramanana, B; Rangel, M S; Raniuk, I; Rauschmayr, N; Raven, G; Redford, S; Reid, M M; dos Reis, A C; Ricciardi, S; Richards, A; Rinnert, K; Rives Molina, V; Roa Romero, D A; Robbe, P; Roberts, D A; Rodrigues, E; Rodriguez Perez, P; Roiser, S; Romanovsky, V; Romero Vidal, A; Rouvinet, J; Ruf, T; Ruffini, F; Ruiz, H; Ruiz Valls, P; Sabatino, G; Saborido Silva, J J; Sagidova, N; Sail, P; Saitta, B; Salustino Guimaraes, V; Sanmartin Sedes, B; Sannino, M; Santacesaria, R; Santamarina Rios, C; Santovetti, E; Sapunov, M; Sarti, A; Satriano, C; Satta, A; Savrie, M; Savrina, D; Schaack, P; Schiller, M; Schindler, H; Schlupp, M; Schmelling, M; Schmidt, B; Schneider, O; Schopper, A; Schune, M -H; Schwemmer, R; Sciascia, B; Sciubba, A; Seco, M; Semennikov, A; Senderowska, K; Sepp, I; Serra, N; Serrano, J; Seyfert, P; Shapkin, M; Shapoval, I; Shatalov, P; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, O; Shevchenko, V; Shires, A; Silva Coutinho, R; Sirendi, M; Skwarnicki, T; Smith, N A; Smith, E; Smith, J; Smith, M; Sokoloff, M D; Soler, F J P; Soomro, F; Souza, D; Souza De Paula, B; Spaan, B; Sparkes, A; Spradlin, P; Stagni, F; Stahl, S; Steinkamp, O; Stevenson, S; Stoica, S; Stone, S; Storaci, B; Straticiuc, M; Straumann, U; Subbiah, V K; Sun, L; Swientek, S; Syropoulos, V; Szczekowski, M; Szczypka, P; Szumlak, T; T'Jampens, S; Teklishyn, M; Teodorescu, E; Teubert, F; Thomas, C; Thomas, E; van Tilburg, J; Tisserand, V; Tobin, M; Tolk, S; Tonelli, D; Topp-Joergensen, S; Torr, N; Tournefier, E; Tourneur, S; Tran, M T; Tresch, M; Tsaregorodtsev, A; Tsopelas, P; Tuning, N; Ubeda Garcia, M; Ukleja, A; Urner, D; Ustyuzhanin, A; Uwer, U; Vagnoni, V; Valenti, G; Vallier, A; Van Dijk, M; Vazquez Gomez, R; Vazquez Regueiro, P; Vázquez Sierra, C; Vecchi, S; Velthuis, J J; Veltri, M; Veneziano, G; Vesterinen, M; Viaud, B; Vieira, D; Vilasis-Cardona, X; Vollhardt, A; Volyanskyy, D; Voong, D; Vorobyev, A; Vorobyev, V; Voß, C; Voss, H; Waldi, R; Wallace, C; Wallace, R; Wandernoth, S; Wang, J; Ward, D R; Watson, N K; Webber, A D; Websdale, D; Whitehead, M; Wicht, J; Wiechczynski, J; Wiedner, D; Wiggers, L; Wilkinson, G; Williams, M P; Williams, M; Wilson, F F; Wimberley, J; Wishahi, J; Wislicki, W; Witek, M; Wotton, S A; Wright, S; Wu, S; Wyllie, K; Xie, Y; Xing, Z; Yang, Z; Young, R; Yuan, X; Yushchenko, O; Zangoli, M; Zavertyaev, M; Zhang, F; Zhang, L; Zhang, W C; Zhang, Y; Zhelezov, A; Zhokhov, A; Zhong, L; Zvyagin, A

    2013-01-01

    The ratio of the $\\Lambda_b^0$ baryon lifetime to that of the $\\overline{B}^0$ meson is measured using 1.0 fb$^{-1}$ of integrated luminosity in 7 TeV center-of-mass energy $pp$ collisions at the LHC. The $\\Lambda_b^0$ baryon is observed for the first time in the decay mode $\\Lambda_b^0 \\to J/\\psi p K^-$, while the $\\overline{B}^0$ meson decay used is the well known $\\overline{B}^0 \\to J/\\psi \\pi^+ K^-$ mode, where the $\\pi^+K^-$ mass is consistent with that of the $\\bar{K}^{*0}(892)$ meson. The ratio of lifetimes is measured to be $0.976\\pm0.012\\pm0.006$, in agreement with theoretical expectations based on the heavy quark expansion. Using previous determinations of the $\\overline{B}^0$ meson lifetime, the $\\Lambda_b^0$ lifetime is found to be $1.482 \\pm 0.018 \\pm 0.012$ ps. In both cases the first uncertainty is statistical and the second systematic.

  9. Observation of $B^{0} \\rightarrow p\\bar{\\Lambda} D^{(*)-}$

    CERN Document Server

    Chang, Y -Y; Abdesselam, A; Adachi, I; Adamczyk, K; Aihara, H; Said, S Al; Asner, D M; Atmacan, H; Aushev, T; Babu, V; Badhrees, I; Bakich, A M; Barberio, E; Bhuyan, B; Biswal, J; Bobrov, A; Bozek, A; Bračko, M; Browder, T E; Červenkov, D; Chekelian, V; Chen, A; Cheon, B G; Chilikin, K; Chistov, R; Chobanova, V; Choi, S -K; Choi, Y; Cinabro, D; Dalseno, J; Danilov, M; Dingfelder, J; Doležal, Z; Drásal, Z; Dutta, D; Eidelman, S; Farhat, H; Fast, J E; Ferber, T; Fulsom, B G; Gaur, V; Gabyshev, N; Ganguly, S; Garmash, A; Gillard, R; Glattauer, R; Goh, Y M; Goldenzweig, P; Greenwald, D; Grzymkowska, O; Haba, J; Hayasaka, K; Hayashii, H; He, X H; Hou, W -S; Hsu, C -L; Iijima, T; Inami, K; Ishikawa, A; Itoh, R; Iwasaki, Y; Jacobs, W W; Jaegle, I; Joffe, D; Joo, K K; Kawasaki, T; Kim, D Y; Kim, H J; Kim, J B; Kim, J H; Kim, K T; Kim, M J; Kim, S H; Kim, Y J; Kinoshita, K; Korpar, S; Križan, P; Krokovny, P; Kuhr, T; Kumita, T; Kuzmin, A; Kwon, Y -J; Lai, Y -T; Lee, I S; Li, L; Li, Y; Libby, J; Liventsev, D; Luki, P; Masuda, M; Miyabayashi, K; Miyake, H; Miyata, H; Mizuk, R; Mohanty, G B; Mohanty, S; Moll, A; Moon, H K; Mori, T; Nakano, E; Nakao, M; Nanut, T; Nayak, M; Nishida, S; Ogawa, S; Ozaki, H; Pakhlov, P; Pakhlova, G; Pal, B; Park, C W; Pedlar, T K; Pestotnik, R; Petrič, M; Piilonen, L E; Rauch, J; Ribežl, E; Ritter, M; Rostomyan, A; Ryu, S; Sahoo, H; Sakai, Y; Sandilya, S; Santelj, L; Sanuki, T; Savinov, V; Schneider, O; Schnell, G; Schwanda, C; Seino, Y; Senyo, K; Seong, I S; Sevior, M E; Shebalin, V; Shen, C P; Shibata, T -A; Shiu, J -G; Simon, F; Sohn, Y -S; Starič, M; Stypula, J; Sumihama, M; Sumisawa, K; Sumiyoshi, T; Tamponi, U; Tanida, K; Teramoto, Y; Uglov, T; Unno, Y; Uno, S; Usov, Y; Van Hulse, C; Vanhoefer, P; Varner, G; Vorobyev, V; Vossen, A; Wagner, M N; Wang, C H; Wang, P; Watanabe, M; Watanabe, Y; Williams, K M; Won, E; Yamaoka, J; Yashchenko, S; Yelton, J; Yusa, Y; Zhang, Z P; Zhulanov, V; Zupanc, A

    2015-01-01

    We report the first observation of the decays $B^0 \\rightarrow p\\bar{\\Lambda} D^{(*)-}$. The data sample of $711$ fb$^{-1}$ used in this analysis corresponds to $772$ million $B\\bar{B}$ pairs, collected at the $\\Upsilon(4S)$ resonance by the Belle detector at the KEKB asymmetric-energy $e^{+}e^{-}$ collider. We observe $19.8\\sigma$ and $10.8\\sigma$ excesses of events for the two decay modes and measure the branching fractions of $B^0 \\rightarrow p\\bar{\\Lambda} D^{-}$ and $B^0 \\rightarrow p\\bar{\\Lambda} D^{*-}$ to be $(25.1\\pm2.6\\pm3.5)\\times10^{-6}$ and $(33.6\\pm6.3\\pm4.4)\\times10^{-6}$, respectively, where the first uncertainties are statistical and the second are systematic. These results are not compatible with the predictions based on the generalized factorization approach. In addition, a threshold enhancement in the di-baryon ($p\\bar{\\Lambda}$) system is observed, consistent with that observed in similar $B$ decays.

  10. A Metric Model of Lambda Calculus with Guarded Recursion

    DEFF Research Database (Denmark)

    Birkedal, Lars; Schwinghammer, Jan; Støvring, Kristian

    We give a model for Nakano’s typed lambda calculus with guarded recursive definitions in a category of metric spaces. By proving a computational adequacy result that relates the interpretation with the operational semantics, we show that the model can be used to reason about contextual equivalence....

  11. Reply to "Comment on `Lattice determination of Sigma - Lambda mixing' "

    CERN Document Server

    Horsley, R; Nakamura, Y; Perlt, H; Pleiter, D; Rakow, P E L; Schierholz, G; Schiller, A; Stüben, H; Zanotti, J M

    2015-01-01

    In this Reply, we respond to the above Comment. Our computation [Phys. Rev. D 91 (2015) 074512] only took into account pure QCD effects, arising from quark mass differences, so it is not surprising that there are discrepancies in isospin splittings and in the Sigma - Lambda mixing angle. We expect that these discrepancies will be smaller in a full calculation incorporating QED effects.

  12. Feasibility study of performing high precision gamma spectroscopy of {lambda}{lambda} hypernuclei in the anti PANDA experiment

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez-Lorente, Alicia

    2010-09-30

    Hypernuclear research will be one of the main topics addressed by the anti PANDA experiment at the planned Facility for Antiproton and Ion Research anti FAIR. Thanks to the use of stored anti p beams, copious production of double {lambda} hypernuclei is expected at the anti PANDA experiment, which will enable high precision {gamma} spectroscopy of such nuclei for the first time. At anti PANDA excited states of {xi}{sup -} hypernuclei will be used as a basis for the formation of double {lambda} hypernuclei. For their detection, a devoted hypernuclear detector setup is planned. This setup consists of a primary nuclear target for the production of {xi}{sup -}+ anti {xi} pairs, a secondary active target for the hypernuclei formation and the identification of associated decay products and a germanium array detector to perform {gamma} spectroscopy. In the present work, the feasibility of performing high precision {gamma} spectroscopy of double {lambda} hypernuclei at the anti PANDA experiment has been studied by means of a Monte Carlo simulation. For this issue, the designing and simulation of the devoted detector setup as well as of the mechanism to produce double {lambda} hypernuclei have been optimized together with the performance of the whole system. In addition, the production yields of double hypernuclei in excitedparticle stable states have been evaluated within a statistical decay model. A strategy for the unique assignment of various newly observed {gamma}-transitions to specific double hypernuclei has been successfully implemented by combining the predicted energy spectra of each target with the measurement of two pion momenta from the subsequent weak decays of a double hypernucleus. Indeed, based on these Monte Carlo simulation, the analysis of the statistical decay of {sup 13}{sub {lambda}}{sub {lambda}}B has been performed. As result, three {gamma}-transitions associated to the double hypernuclei {sup 11}{sub {lambda}}{sub {lambda}}Be and to the single

  13. The isolation and characterization of Campylobacter jejuni bacteriophages from free range and indoor poultry.

    Science.gov (United States)

    Owens, Jane; Barton, Mary D; Heuzenroeder, Michael W

    2013-02-22

    Six hundred and sixty one samples - primarily fresh chicken faeces - were processed to isolate wild type Campylobacter jejuni bacteriophages, via overlay agar methods using C. jejuni NCTC 12662. The aims of this study were to isolate and purify bacteriophages and then test for their ability to lyse field strains of C. jejuni in vitro. Of all samples processed, 130 were positive for bacteriophages. A distinct difference was observed between samples from different poultry enterprises. No bacteriophages could be isolated from indoor broilers. The majority of bacteriophages were isolated from free range poultry - both broilers and egg layers. Bacteriophages were purified and then selected for characterization based on their ability to produce clear lysis on plaque assay, as opposed to turbid plaques. Two hundred and forty one C. jejuni field isolates were tested for sensitivity to the bacteriophages. Lysis was graded subjectively and any minimal lysis was excluded. Using this system, 59.0% of the C. jejuni isolates showed significant sensitivity to at least one bacteriophage. The sensitivity to individual bacteriophages ranged from 10.0% to 32.5% of the C. jejuni isolates. Five bacteriophages were examined by electron microscopy and determined to belong to the Myoviridae family. The physical size, predicted genetic composition and genome size of the bacteriophages correlated well with other reported Campylobacter bacteriophages. The reasons for the observed difference between indoor broilers and free range poultry is unknown, but are postulated to be due to differences in the Campylobacter population in birds under different rearing conditions.

  14. Interrupted thymidylate synthase gene of bacteriophages T2 and T6 and other potential self-splicing introns in the T-even bacteriophages

    Energy Technology Data Exchange (ETDEWEB)

    Chu, F.K.; Maley, F.; Martinez, J.; Maley, G.F.

    1987-09-01

    Southern hybridization analyses of procaryotic DNA from Escherchia coli, lambda bacteriophage, and T1 to T7 phages were carried out. The hybridization probes used consisted of DNA restriction fragments derived from the T4 phage intron-containing thymidylate synthase gene (td) and short synthetic oligodeoxynucleotides defining specific exon and intron regions of the gene. It was shown that intact as well as restricted DNA from the T-even phages hybridized not only to both T4 phage td intron- and exon-specific probes but also to probes defining the td 5' (exon I-intron) and 3' (intron-exon II) presplice junctions. These data strongly suggest that, analogous to the T4 phage, only the T2 and T6 phages among the procaryotes tested contain interrupted td genes. The td intervening sequence in each phage is roughly 1 kilobase pair (kb) in size and interrupts the td gene at a site analogous to that in the T4 phage. This was confirmed by data from Northern (RNA) hybridization analysis of td-specific in vitro transcripts of these phage DNAs. (..cap alpha..-/sup 32/P)GTP in vitro labeling of total RNA from T4 phage-infected cells produced five species of labeled RNAs that were 1, 0.9, 0.83, 0.75, and 0.6 kb in size. Only the 1-, 0.9-, and 0.75-kb species were labeled in RNA from T2- or T6-infected cells. The commonly present 1-kb RNA is the excised td intron, which exists in both linear and circular forms in the respective T-even-phage-infected cells, while the 0.6-kb RNA unique to T4 may be the excised intron derived from the ribonucleotide reductase small subunit gene (nrdB) of the phage. The remaining labeled RNA species are likely candidates for other self-splicing introns.

  15. Scaled momentum distributions for K{sup 0}{sub S} and {lambda}/ anti {lambda} in DIS at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Abramowicz, H. [Tel Aviv Univ. (Israel). School of Physics; Max Planck Institute for Physics, Munich (Germany); Abt, I. [Max Planck Institute for Physics, Munich (Germany); Adamczyk, L. [AGH-Univ. of Science and Technology, Krakow (PL). Faculty of Physics and Applied Computer Science] (and others)

    2011-11-15

    Scaled momentum distributions for the strange hadrons K{sub S}{sup 0} and {lambda}/ anti {lambda} were measured in deep inelastic ep scattering with the ZEUS detector at HERA using an integrated luminosity of 330 pb{sup -1}. The evolution of these distributions with the photon virtuality, Q{sup 2}, was studied in the kinematic region 10lambda}/ anti {lambda} strange hadrons. (orig.)

  16. On the employment of lambda carrageenan in a matrix system. III. Optimization of a lambda carrageenan-HPMC hydrophilic matrix

    NARCIS (Netherlands)

    Bonferoni, MC; Rossi, S; Ferrari, F; Bertoni, M; Bolhuis, GK; Caramella, C

    1998-01-01

    The lambda carrageenan/HPMC ratio in matrix tablets has been optimized in order to obtain pH-independent release profiles of chlorpheniramine maleate, a freely soluble drug. Release profiles in acidic (pH 1.2) and neutral (pH 6.8) media were fitted according to the Weibull and the power law models.

  17. From $\\Xi_b \\to \\Lambda_b \\pi$ to $\\Xi_c \\to \\Lambda_c \\pi$

    CERN Document Server

    Gronau, Michael

    2016-01-01

    Using a successful framework for describing S-wave hadronic decays of light hyperons induced by a subprocess $s \\to u (\\bar u d)$, we presented recently a model-independent calculation of the amplitude and branching ratio for $\\Xi^-_b \\to \\Lambda_b \\pi^-$ in agreement with a LHCb measurement. The same quark process contributes to $\\Xi^0_c \\to \\Lambda_c \\pi^-$, while a second term from the subprocess $cs \\to cd$ has been related by Voloshin to differences among total decay rates of charmed baryons. We calculate this term and find it to have a magnitude approximately equal to the $s \\to u (\\bar u d)$ term. We argue for a negligible relative phase between these two contributions, potentially due to final state interactions. However, we do not know whether they interfere destructively or constructively. For constructive interference one predicts ${\\cal B}(\\Xi_c^0 \\to \\Lambda_c \\pi^-) = (1.94 \\pm 0.70)\\times 10^{-3}$ and ${\\cal B}(\\Xi_c^+ \\to \\Lambda_c \\pi^0) = (3.83 \\pm 1.38)\\times 10^{-3}$. For destructive inter...

  18. Propagation of heavy baryons in heavy-ion collisions. Part I: $\\Lambda_c$ and $\\Lambda_b$ transport coefficients

    CERN Document Server

    Tolos, Laura; Das, Santosh K

    2016-01-01

    We compute the transport coefficients (drag and momentum diffusion) of the low-lying heavy baryons $\\Lambda_c$ and $\\Lambda_b$ in a medium of light mesons formed at the later stages of high-energy heavy-ion collisions. We employ the Fokker-Planck approach to obtain the transport coefficients from unitarized baryon-meson interactions based on effective field theories that respect chiral and heavy-quark symmetries. We provide the transport coefficients as a function of temperature and heavy-baryon momentum, and analyze the applicability of certain non-relativistic estimates. Moreover we compare our outcome for the spatial diffusion coefficient to the one coming from the solution of the Boltzmann-Uehling-Uhlenbeck transport equation and we find a very good agreement between both calculations. The transport coefficients for $\\Lambda_c$ and $\\Lambda_b$ in a thermal bath will be used in a subsequent publication as input in a Langevin evolution code for the generation and propagation of heavy particles in heavy-ion ...

  19. Studies of beauty baryon decays to $D^0 ph^-$ and $\\Lambda_c^+ h^-$ final states

    CERN Document Server

    Aaij, Roel; Adinolfi, Marco; Adrover, Cosme; Affolder, Anthony; Ajaltouni, Ziad; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; Anderlini, Lucio; Anderson, Jonathan; Andreassen, Rolf; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Aquines Gutierrez, Osvaldo; Archilli, Flavio; Artamonov, Alexander; Artuso, Marina; Aslanides, Elie; Auriemma, Giulio; Baalouch, Marouen; Bachmann, Sebastian; Back, John; Badalov, Alexey; Balagura, Vladislav; Baldini, Wander; Barlow, Roger; Barschel, Colin; Barsuk, Sergey; Barter, William; Batozskaya, Varvara; Bauer, Thomas; Bay, Aurelio; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Belogurov, Sergey; Belous, Konstantin; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Benton, Jack; Berezhnoy, Alexander; Bernet, Roland; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bien, Alexander; Bifani, Simone; Bird, Thomas; Bizzeti, Andrea; Bjørnstad, Pål Marius; Blake, Thomas; Blanc, Frédéric; Blouw, Johan; Blusk, Steven; Bocci, Valerio; Bondar, Alexander; Bondar, Nikolay; Bonivento, Walter; Borghi, Silvia; Borgia, Alessandra; Bowcock, Themistocles; Bowen, Espen Eie; Bozzi, Concezio; Brambach, Tobias; van den Brand, Johannes; Bressieux, Joël; Brett, David; Britsch, Markward; Britton, Thomas; Brook, Nicholas; Brown, Henry; Bursche, Albert; Busetto, Giovanni; Buytaert, Jan; Cadeddu, Sandro; Calabrese, Roberto; Callot, Olivier; Calvi, Marta; Calvo Gomez, Miriam; Camboni, Alessandro; Campana, Pierluigi; Campora Perez, Daniel; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carranza-Mejia, Hector; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casse, Gianluigi; Castillo Garcia, Lucia; Cattaneo, Marco; Cauet, Christophe; Cenci, Riccardo; Charles, Matthew; Charpentier, Philippe; Cheung, Shu-Faye; Chiapolini, Nicola; Chrzaszcz, Marcin; Ciba, Krzystof; Cid Vidal, Xabier; Ciezarek, Gregory; Clarke, Peter; Clemencic, Marco; Cliff, Harry; Closier, Joel; Coca, Cornelia; Coco, Victor; Cogan, Julien; Cogneras, Eric; Collins, Paula; Comerma-Montells, Albert; Contu, Andrea; Cook, Andrew; Coombes, Matthew; Coquereau, Samuel; Corti, Gloria; Couturier, Benjamin; Cowan, Greig; Craik, Daniel Charles; Cruz Torres, Melissa Maria; Cunliffe, Samuel; Currie, Robert; D'Ambrosio, Carmelo; Dalseno, Jeremy; David, Pascal; David, Pieter; Davis, Adam; De Bonis, Isabelle; De Bruyn, Kristof; De Capua, Stefano; De Cian, Michel; De Miranda, Jussara; De Paula, Leandro; De Silva, Weeraddana; De Simone, Patrizia; Decamp, Daniel; Deckenhoff, Mirko; Del Buono, Luigi; Déléage, Nicolas; Derkach, Denis; Deschamps, Olivier; Dettori, Francesco; Di Canto, Angelo; Dijkstra, Hans; Dogaru, Marius; Donleavy, Stephanie; Dordei, Francesca; Dorosz, Piotr; Dosil Suárez, Alvaro; Dossett, David; Dovbnya, Anatoliy; Dupertuis, Frederic; Durante, Paolo; Dzhelyadin, Rustem; Dziurda, Agnieszka; Dzyuba, Alexey; Easo, Sajan; Egede, Ulrik; Egorychev, Victor; Eidelman, Semen; van Eijk, Daan; Eisenhardt, Stephan; Eitschberger, Ulrich; Ekelhof, Robert; Eklund, Lars; El Rifai, Ibrahim; Elsasser, Christian; Falabella, Antonio; Färber, Christian; Farinelli, Chiara; Farry, Stephen; Ferguson, Dianne; Fernandez Albor, Victor; Ferreira Rodrigues, Fernando; Ferro-Luzzi, Massimiliano; Filippov, Sergey; Fiore, Marco; Fiorini, Massimiliano; Fitzpatrick, Conor; Fontana, Marianna; Fontanelli, Flavio; Forty, Roger; Francisco, Oscar; Frank, Markus; Frei, Christoph; Frosini, Maddalena; Furfaro, Emiliano; Gallas Torreira, Abraham; Galli, Domenico; Gandelman, Miriam; Gandini, Paolo; Gao, Yuanning; Garofoli, Justin; Garosi, Paola; Garra Tico, Jordi; Garrido, Lluis; Gaspar, Clara; Gauld, Rhorry; Gersabeck, Evelina; Gersabeck, Marco; Gershon, Timothy; Ghez, Philippe; Gibson, Valerie; Giubega, Lavinia-Helena; Gligorov, Vladimir; Göbel, Carla; Golubkov, Dmitry; Golutvin, Andrey; Gomes, Alvaro; Gordon, Hamish; Grabalosa Gándara, Marc; Graciani Diaz, Ricardo; Granado Cardoso, Luis Alberto; Graugés, Eugeni; Graziani, Giacomo; Grecu, Alexandru; Greening, Edward; Gregson, Sam; Griffith, Peter; Grillo, Lucia; Grünberg, Oliver; Gui, Bin; Gushchin, Evgeny; Guz, Yury; Gys, Thierry; Hadjivasiliou, Christos; Haefeli, Guido; Haen, Christophe; Hafkenscheid, Tom; Haines, Susan; Hall, Samuel; Hamilton, Brian; Hampson, Thomas; Hansmann-Menzemer, Stephanie; Harnew, Neville; Harnew, Samuel; Harrison, Jonathan; Hartmann, Thomas; He, Jibo; Head, Timothy; Heijne, Veerle; Hennessy, Karol; Henrard, Pierre; Hernando Morata, Jose Angel; van Herwijnen, Eric; Heß, Miriam; Hicheur, Adlène; Hicks, Emma; Hill, Donal; Hoballah, Mostafa; Hombach, Christoph; Hulsbergen, Wouter; Hunt, Philip; Huse, Torkjell; Hussain, Nazim; Hutchcroft, David; Hynds, Daniel; Iakovenko, Viktor; Idzik, Marek; Ilten, Philip; Jacobsson, Richard; Jaeger, Andreas; Jans, Eddy; Jaton, Pierre; Jawahery, Abolhassan; Jing, Fanfan; John, Malcolm; Johnson, Daniel; Jones, Christopher; Joram, Christian; Jost, Beat; Jurik, Nathan; Kaballo, Michael; Kandybei, Sergii; Kanso, Wallaa; Karacson, Matthias; Karbach, Moritz; Kenyon, Ian; Ketel, Tjeerd; Khanji, Basem; Klaver, Suzanne; Kochebina, Olga; Komarov, Ilya; Koopman, Rose; Koppenburg, Patrick; Korolev, Mikhail; Kozlinskiy, Alexandr; Kravchuk, Leonid; Kreplin, Katharina; Kreps, Michal; Krocker, Georg; Krokovny, Pavel; Kruse, Florian; Kucharczyk, Marcin; Kudryavtsev, Vasily; Kurek, Krzysztof; Kvaratskheliya, Tengiz; La Thi, Viet Nga; Lacarrere, Daniel; Lafferty, George; Lai, Adriano; Lambert, Dean; Lambert, Robert W; Lanciotti, Elisa; Lanfranchi, Gaia; Langenbruch, Christoph; Latham, Thomas; Lazzeroni, Cristina; Le Gac, Renaud; van Leerdam, Jeroen; Lees, Jean-Pierre; Lefèvre, Regis; Leflat, Alexander; Lefrançois, Jacques; Leo, Sabato; Leroy, Olivier; Lesiak, Tadeusz; Leverington, Blake; Li, Yiming; Li Gioi, Luigi; Liles, Myfanwy; Lindner, Rolf; Linn, Christian; Lionetto, Federica; Liu, Bo; Liu, Guoming; Lohn, Stefan; Longstaff, Ian; Lopes, Jose; Lopez-March, Neus; Lu, Haiting; Lucchesi, Donatella; Luisier, Johan; Luo, Haofei; Luppi, Eleonora; Lupton, Oliver; Machefert, Frederic; Machikhiliyan, Irina V; Maciuc, Florin; Maev, Oleg; Malde, Sneha; Manca, Giulia; Mancinelli, Giampiero; Maratas, Jan; Marconi, Umberto; Marino, Pietro; Märki, Raphael; Marks, Jörg; Martellotti, Giuseppe; Martens, Aurelien; Martín Sánchez, Alexandra; Martinelli, Maurizio; Martinez Santos, Diego; Martins Tostes, Danielle; Martynov, Aleksandr; Massafferri, André; Matev, Rosen; Mathe, Zoltan; Matteuzzi, Clara; Maurice, Emilie; Mazurov, Alexander; McCann, Michael; McCarthy, James; McNab, Andrew; McNulty, Ronan; McSkelly, Ben; Meadows, Brian; Meier, Frank; Meissner, Marco; Merk, Marcel; Milanes, Diego Alejandro; Minard, Marie-Noelle; Molina Rodriguez, Josue; Monteil, Stephane; Moran, Dermot; Morawski, Piotr; Mordà, Alessandro; Morello, Michael Joseph; Mountain, Raymond; Mous, Ivan; Muheim, Franz; Müller, Katharina; Muresan, Raluca; Muryn, Bogdan; Muster, Bastien; Naik, Paras; Nakada, Tatsuya; Nandakumar, Raja; Nasteva, Irina; Needham, Matthew; Neubert, Sebastian; Neufeld, Niko; Nguyen, Anh Duc; Nguyen, Thi-Dung; Nguyen-Mau, Chung; Nicol, Michelle; Niess, Valentin; Niet, Ramon; Nikitin, Nikolay; Nikodem, Thomas; Nomerotski, Andrey; Novoselov, Alexey; Oblakowska-Mucha, Agnieszka; Obraztsov, Vladimir; Oggero, Serena; Ogilvy, Stephen; Okhrimenko, Oleksandr; Oldeman, Rudolf; Onderwater, Gerco; Orlandea, Marius; Otalora Goicochea, Juan Martin; Owen, Patrick; Oyanguren, Maria Arantza; Pal, Bilas Kanti; Palano, Antimo; Palutan, Matteo; Panman, Jacob; Papanestis, Antonios; Pappagallo, Marco; Pappalardo, Luciano; Parkes, Christopher; Parkinson, Christopher John; Passaleva, Giovanni; Patel, Girish; Patel, Mitesh; Patrignani, Claudia; Pavel-Nicorescu, Carmen; Pazos Alvarez, Antonio; Pearce, Alex; Pellegrino, Antonio; Penso, Gianni; Pepe Altarelli, Monica; Perazzini, Stefano; Perez Trigo, Eliseo; Pérez-Calero Yzquierdo, Antonio; Perret, Pascal; Perrin-Terrin, Mathieu; Pescatore, Luca; Pesen, Erhan; Pessina, Gianluigi; Petridis, Konstantin; Petrolini, Alessandro; Picatoste Olloqui, Eduardo; Pietrzyk, Boleslaw; Pilař, Tomas; Pinci, Davide; Playfer, Stephen; Plo Casasus, Maximo; Polci, Francesco; Polok, Grzegorz; Poluektov, Anton; Polycarpo, Erica; Popov, Alexander; Popov, Dmitry; Popovici, Bogdan; Potterat, Cédric; Powell, Andrew; Prisciandaro, Jessica; Pritchard, Adrian; Prouve, Claire; Pugatch, Valery; Puig Navarro, Albert; Punzi, Giovanni; Qian, Wenbin; Rachwal, Bartolomiej; Rademacker, Jonas; Rakotomiaramanana, Barinjaka; Rangel, Murilo; Raniuk, Iurii; Rauschmayr, Nathalie; Raven, Gerhard; Redford, Sophie; Reichert, Stefanie; Reid, Matthew; dos Reis, Alberto; Ricciardi, Stefania; Richards, Alexander; Rinnert, Kurt; Rives Molina, Vincente; Roa Romero, Diego; Robbe, Patrick; Roberts, Douglas; Rodrigues, Ana Barbara; Rodrigues, Eduardo; Rodriguez Perez, Pablo; Roiser, Stefan; Romanovsky, Vladimir; Romero Vidal, Antonio; Rotondo, Marcello; Rouvinet, Julien; Ruf, Thomas; Ruffini, Fabrizio; Ruiz, Hugo; Ruiz Valls, Pablo; Sabatino, Giovanni; Saborido Silva, Juan Jose; Sagidova, Naylya; Sail, Paul; Saitta, Biagio; Salustino Guimaraes, Valdir; Sanmartin Sedes, Brais; Santacesaria, Roberta; Santamarina Rios, Cibran; Santovetti, Emanuele; Sapunov, Matvey; Sarti, Alessio; Satriano, Celestina; Satta, Alessia; Savrie, Mauro; Savrina, Darya; Schiller, Manuel; Schindler, Heinrich; Schlupp, Maximilian; Schmelling, Michael; Schmidt, Burkhard; Schneider, Olivier; Schopper, Andreas; Schune, Marie Helene; Schwemmer, Rainer; Sciascia, Barbara; Sciubba, Adalberto; Seco, Marcos; Semennikov, Alexander; Senderowska, Katarzyna; Sepp, Indrek; Serra, Nicola; Serrano, Justine; Seyfert, Paul; Shapkin, Mikhail; Shapoval, Illya; Shcheglov, Yury; Shears, Tara; Shekhtman, Lev; Shevchenko, Oksana; Shevchenko, Vladimir; Shires, Alexander; Silva Coutinho, Rafael; Sirendi, Marek; Skidmore, Nicola; Skwarnicki, Tomasz; Smith, Anthony; Smith, Edmund; Smith, Eluned; Smith, Jackson; Smith, Mark; Sokoloff, Michael; Soler, Paul; Soomro, Fatima; Souza, Daniel; Souza De Paula, Bruno; Spaan, Bernhard; Sparkes, Ailsa; Spradlin, Patrick; Stagni, Federico; Stahl, Sascha; Steinkamp, Olaf; Stevenson, Scott; Stoica, Sabin; Stone, Sheldon; Storaci, Barbara; Stracka, Simone; Straticiuc, Mihai; Straumann, Ulrich; Subbiah, Vijay Kartik; Sun, Liang; Sutcliffe, William; Swientek, Stefan; Syropoulos, Vasileios; Szczekowski, Marek; Szczypka, Paul; Szilard, Daniela; Szumlak, Tomasz; T'Jampens, Stephane; Teklishyn, Maksym; Tellarini, Giulia; Teodorescu, Eliza; Teubert, Frederic; Thomas, Christopher; Thomas, Eric; van Tilburg, Jeroen; Tisserand, Vincent; Tobin, Mark; Tolk, Siim; Tomassetti, Luca; Tonelli, Diego; Topp-Joergensen, Stig; Torr, Nicholas; Tournefier, Edwige; Tourneur, Stephane; Tran, Minh Tâm; Tresch, Marco; Tsaregorodtsev, Andrei; Tsopelas, Panagiotis; Tuning, Niels; Ubeda Garcia, Mario; Ukleja, Artur; Ustyuzhanin, Andrey; Uwer, Ulrich; Vagnoni, Vincenzo; Valenti, Giovanni; Vallier, Alexis; Vazquez Gomez, Ricardo; Vazquez Regueiro, Pablo; Vázquez Sierra, Carlos; Vecchi, Stefania; Velthuis, Jaap; Veltri, Michele; Veneziano, Giovanni; Vesterinen, Mika; Viaud, Benoit; Vieira, Daniel; Vilasis-Cardona, Xavier; Vollhardt, Achim; Volyanskyy, Dmytro; Voong, David; Vorobyev, Alexey; Vorobyev, Vitaly; Voß, Christian; Voss, Helge; de Vries, Jacco; Waldi, Roland; Wallace, Charlotte; Wallace, Ronan; Wandernoth, Sebastian; Wang, Jianchun; Ward, David; Watson, Nigel; Webber, Adam Dane; Websdale, David; Whitehead, Mark; Wicht, Jean; Wiechczynski, Jaroslaw; Wiedner, Dirk; Wiggers, Leo; Wilkinson, Guy; Williams, Matthew; Williams, Mike; Wilson, Fergus; Wimberley, Jack; Wishahi, Julian; Wislicki, Wojciech; Witek, Mariusz; Wormser, Guy; Wotton, Stephen; Wright, Simon; Wu, Suzhi; Wyllie, Kenneth; Xie, Yuehong; Xing, Zhou; Yang, Zhenwei; Yuan, Xuhao; Yushchenko, Oleg; Zangoli, Maria; Zavertyaev, Mikhail; Zhang, Feng; Zhang, Liming; Zhang, Wen Chao; Zhang, Yanxi; Zhelezov, Alexey; Zhokhov, Anatoly; Zhong, Liang; Zvyagin, Alexander

    2014-01-01

    Decays of beauty baryons to the $D^0 p h^-$ and $\\Lambda_c^+ h^-$ final states (where $h$ indicates a pion or a kaon) are studied using a data sample of $pp$ collisions, corresponding to an integrated luminosity of 1.0 fb$^{-1}$, collected by the LHCb detector. The Cabibbo-suppressed decays $\\Lambda_b^0\\to D^0 p K^-$ and $\\Lambda_b^0\\to \\Lambda_c^+ K^-$ are observed and their branching fractions are measured with respect to the decays $\\Lambda_b^0\\to D^0 p \\pi^-$ and $\\Lambda_b^0\\to \\Lambda_c^+ \\pi^-$. In addition, the first observation is reported of the decay of the neutral beauty-strange baryon $\\Xi_b^0$ to the $D^0 p K^-$ final state, and a measurement of the $\\Xi_b^0$ mass is performed. Evidence of the $\\Xi_b^0\\to \\Lambda_c^+ K^-$ decay is also reported.

  20. Search for the Baryon and Lepton Number Violating Decays tau -> Lambda h

    CERN Document Server

    Aubert, B; Bóna, M; Boutigny, D; Couderc, F; Karyotakis, Yu; Lees, J P; Poireau, V; Tisserand, V; Zghiche, A; Graugès-Pous, E; Palano, A; Chen, J C; Qi, N D; Rong, G; Wang, P; Zhu, Y S; Eigen, G; Ofte, I; Stugu, B; Abrams, G S; Battaglia, M; Brown, D N; Button-Shafer, J; Cahn, R N; Charles, E; Gill, M S; Groysman, Y; Jacobsen, R G; Kadyk, J A; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; Lynch, G; Mir, L M; Orimoto, T J; Pripstein, M; Roe, N A; Ronan, M T; Wenzel, W A; Del Amo-Sánchez, P; Barrett, M; Ford, K E; Hart, A J; Harrison, T J; Hawkes, C M; Morgan, S E; Watson, A T; Held, T; Koch, H; Lewandowski, B; Pelizaeus, M; Peters, K; Schröder, T; Steinke, M; Boyd, J T; Burke, J P; Cottingham, W N; Walker, D; Asgeirsson, D J; Çuhadar-Dönszelmann, T; Fulsom, B G; Hearty, C; Knecht, N S; Mattison, T S; McKenna, J A; Khan, A; Kyberd, P; Saleem, M; Sherwood, D J; Teodorescu, L; Blinov, V E; Bukin, A D; Druzhinin, V P; Golubev, V B; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Todyshev, K Y; Best, D S; Bondioli, M; Bruinsma, M; Chao, M; Curry, S; Eschrich, I; Kirkby, D; Lankford, A J; Lund, P; Mandelkern, M A; Mommsen, R K; Röthel, W; Stoker, D P; Abachi, S; Buchanan, C; Foulkes, S D; Gary, J W; Long, O; Shen, B C; Wang, K; Zhang, L; Hadavand, H K; Hill, E J; Paar, H P; Rahatlou, S; Sharma, V; Berryhill, J W; Campagnari, C; Cunha, A; Dahmes, B; Hong, T M; Kovalskyi, D; Richman, J D; Beck, T W; Eisner, A M; Flacco, C J; Heusch, C A; Kroseberg, J; Lockman, W S; Nesom, G; Schalk, T; Schumm, B A; Seiden, A; Spradlin, P; Williams, D C; Wilson, M G; Albert, J; Chen, E; Dvoretskii, A; Fang, F; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Ryd, A; Samuel, A; Mancinelli, G; Meadows, B T; Mishra, K; Sokoloff, M D; Blanc, F; Bloom, P C; Chen, S; Ford, W T; Hirschauer, J F; Kreisel, A; Nagel, M; Nauenberg, U; Olivas, A; Ruddick, W O; Smith, J G; Ulmer, K A; Wagner, S R; Zhang, J; Chen, A; Eckhart, E A; Soffer, A; Toki, W H; Wilson, R J; Winklmeier, F; Zeng, Q; Altenburg, D D; Feltresi, E; Hauke, A; Jasper, H; Merkel, J; Petzold, A; Spaan, B; Brandt, T; Klose, V; Lacker, H M; Mader, W F; Nogowski, R; Schubert, J; Schubert, K R; Schwierz, R; Sundermann, J E; Volk, A; Bernard, D; Bonneaud, G R; Latour, E; Thiebaux, C; Verderi, M; Clark, P J; Gradl, W; Muheim, F; Playfer, S; Robertson, A I; Xie, Y; Andreotti, M; Bettoni, D; Bozzi, C; Calabrese, R; Cibinetto, G; Luppi, E; Negrini, M; Petrella, A; Piemontese, L; Prencipe, E; Anulli, F; Baldini-Ferroli, R; Calcaterra, A; De Sangro, R; Finocchiaro, G; Pacetti, S; Patteri, P; Peruzzi, I M; Piccolo, M; Rama, M; Zallo, A; Buzzo, A; Capra, R; Contri, R; Lo Vetere, M; Macri, M M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Brandenburg, G; Chaisanguanthum, K S; Morii, M; Wu, J; Dubitzky, R S; Marks, J; Schenk, S; Uwer, U; Bard, D J; Bhimji, W; Bowerman, D A; Dauncey, P D; Egede, U; Flack, R L; Nash, J A; Nikolich, M B; Panduro-Vazquez, W; Behera, P K; Chai, X; Charles, M J; Mallik, U; Meyer, N T; Ziegler, V; Cochran, J; Crawley, H B; Dong, L; Eyges, V; Meyer, W T; Prell, S; Rosenberg, E I; Rubin, A E; Gritsan, A V; Denig, A G; Fritsch, M; Schott, G; Arnaud, N; Davier, M; Grosdidier, G; Höcker, A; Le Diberder, F R; Lepeltier, V; Lutz, A M; Oyanguren, A; Pruvot, S; Rodier, S; Roudeau, P; Schune, M H; Stocchi, A; Wang, W F; Wormser, G; Cheng, C H; Lange, D J; Wright, D M; Chavez, C A; Forster, I J; Fry, J R; Gabathuler, E; Gamet, R; George, K A; Hutchcroft, D E; Payne, D J; Schofield, K C; Touramanis, C; Bevan, A J; Di Lodovico, F; Menges, W; Sacco, R; Cowan, G; Flächer, H U; Hopkins, D A; Jackson, P S; McMahon, T R; Ricciardi, S; Salvatore, F; Wren, A C; Davis, C L; Allison, J; Barlow, N R; Barlow, R J; Chia, Y M; Edgar, C L; Lafferty, G D; Naisbit, M T; Williams, J C; Yi, J I; Chen, C; Hulsbergen, W D; Jawahery, A; Lae, C K; Roberts, D A; Simi, G; Blaylock, G; Dallapiccola, C; Hertzbach, S S; Li, X; Moore, T B; Saremi, S; Stängle, H; Cowan, R; Sciolla, G; Sekula, S J; Spitznagel, M; Taylor, F; Yamamoto, R K; Kim, H; Mclachlin, S E; Patel, P M; Robertson, S H; Lazzaro, A; Lombardo, V; Palombo, F; Bauer, J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Côté, D; Simard, M; Taras, P; Viaud, F B; Nicholson, H; Cavallo, N; De Nardo, Gallieno; Fabozzi, F; Gatto, C; Lista, L; Monorchio, D; Paolucci, P; Piccolo, D; Sciacca, C; Baak, M A; Raven, G; Snoek, H L; Jessop, C P; LoSecco, J M; Allmendinger, T; Benelli, G; Corwin, L A; Gan, K K; Honscheid, K; Hufnagel, D; Jackson, P D; Kagan, H; Kass, R; Rahimi, A M; Regensburger, J J; Ter-Antonian, R; Wong, Q K; Blount, N L; Brau, J E; Frey, R; Igonkina, O; Kolb, J A; Lu, M; Rahmat, R; Sinev, N B; Strom, D; Strube, J; Torrence, E; Gaz, A; Margoni, M; Morandin, M; Pompili, A; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Voci, C; Benayoun, M; Briand, H; Chauveau, J; David, P; Del Buono, L; La Vaissière, C de; Hamon, O; Hartfiel, B L; John, M J J; Leruste, P; Malcles, J; Ocariz, J; Roos, L; Therin, G; Gladney, L; Panetta, J; Biasini, M; Covarelli, R; Angelini, C; Batignani, G; Bettarini, S; Bucci, F; Calderini, G; Carpinelli, M; Cenci, R; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Mazur, M A; Morganti, M; Neri, N; Paoloni, E; Rizzo, G; Walsh, J J; Haire, M; Judd, D; Wagoner, D E; Biesiada, J; Danielson, N; Elmer, P; Lau, Y P; Lü, C; Olsen, J; Smith, A J S; Telnov, A V; Bellini, F; Cavoto, G; D'Orazio, A; Del Re, D; Di Marco, E; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Li Gioi, L; Mazzoni, M A; Morganti, S; Piredda, G; Polci, F; Safai-Tehrani, F; Voena, C; Ebert, M; Schröder, H; Waldi, R; Adye, T; De Groot, N; Franek, B; Olaiya, E O; Wilson, F F; Aleksan, R; Emery, S; Gaidot, A; Ganzhur, S F; Hamel de Monchenault, G; Kozanecki, Witold; Legendre, M; Vasseur, G; Yéche, C; Zito, M; Chen, X R; Liu, H; Park, W; Purohit, M V; Wilson, J R; Allen, M T; Aston, D; Bartoldus, R; Bechtle, P; Berger, N; Claus, R; Coleman, J P; Convery, M R; Cristinziani, M; Dingfelder, J C; Dorfan, J; Dubois-Felsmann, G P; Dujmic, D; Dunwoodie, W M; Field, R C; Glanzman, T; Gowdy, S J; Graham, M T; Grenier, P; Halyo, V; Hast, C; Hrynóva, T; Innes, W R; Kelsey, M H; Kim, P; Leith, D W G S; Li, S; Luitz, S; Lüth, V; Lynch, H L; MacFarlane, D B; Marsiske, H; Messner, R; Müller, D R; O'Grady, C P; Ozcan, V E; Perazzo, A; Perl, M; Pulliam, T; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Snyder, A; Stelzer, J; Su, D; Sullivan, M K; Suzuki, K; Swain, S K; Thompson, J M; Vavra, J; Van Bakel, N; Weaver, M; Weinstein, A J R; Wisniewski, W J; Wittgen, M; Wright, D H; Yarritu, A K; Yi, K; Young, C C; Burchat, P R; Edwards, A J; Majewski, S A; Petersen, B A; Roat, C; Wilden, L; Ahmed, S; Alam, M S; Bula, R; Ernst, J A; Jain, V; Pan, B; Saeed, M A; Wappler, F R; Zain, S B; Bugg, W; Krishnamurthy, M; Spanier, S M; Eckmann, R; Ritchie, J L; Satpathy, A; Schilling, C J; Schwitters, R F; Izen, J M; Lou, X C; Ye, S; Bianchi, F; Gallo, F; Gamba, D; Bomben, M; Bosisio, L; Cartaro, C; Cossutti, F; Della Ricca, G; Dittongo, S; Lanceri, L; Vitale, L; Azzolini, V; Lopez-March, N; Martínez-Vidal, F; Banerjee, S; Bhuyan, B; Brown, C M; Fortin, D; Hamano, K; Kowalewski, R V; Nugent, I M; Roney, J M; Sobie, R J; Back, J J; Harrison, P F; Latham, T E; Mohanty, G B; Pappagallo, M; Band, H R; Chen, X; Cheng, B; Dasu, S; Datta, M; Flood, K T; Hollar, J J; Kutter, P E; Mellado, B; Mihályi, A; Pan, Y; Pierini, M; Prepost, R; Wu, S L; Yu, Z; Neal, H

    2006-01-01

    We have searched for the violation of baryon number B and lepton number L in the (B-L)-conserving modes tau- -> anti-Lambda0 pi- and tau- -> anti-Lambda0 K- as well as the (B-L)-violating modes tau- -> Lambda0 pi- and tau- -> Lambda0 K- using 237 inv. fb of data collected with the BABAR detector at the PEP-II asymmetric-energy e+e- storage ring. We do not observe any signal and determine preliminary upper limits on the branching fractions B(tau- -> anti-Lambda0 pi-) Lambda0 pi-) anti-Lambda0 K-) Lambda0 K-) < 15 x 10^-8 at 90% confidence level.

  1. Measurement of the $\\Lambda_b^0$ lifetime and mass in the ATLAS experiment

    CERN Document Server

    Aad, Georges; Abdallah, Jalal; Abdel Khalek, Samah; Abdelalim, Ahmed Ali; Abdinov, Ovsat; Aben, Rosemarie; Abi, Babak; Abolins, Maris; AbouZeid, Ossama; Abramowicz, Halina; Abreu, Henso; Acerbi, Emilio; Acharya, Bobby Samir; Adamczyk, Leszek; Adams, David; Addy, Tetteh; Adelman, Jahred; Adomeit, Stefanie; Adragna, Paolo; Adye, Tim; Aefsky, Scott; Aguilar-Saavedra, Juan Antonio; Agustoni, Marco; Aharrouche, Mohamed; Ahlen, Steven; Ahles, Florian; Ahmad, Ashfaq; Ahsan, Mahsana; Aielli, Giulio; Akdogan, Taylan; Åkesson, Torsten Paul Ake; Akimoto, Ginga; Akimov, Andrei; Alam, Mohammad; Alam, Muhammad Aftab; Albert, Justin; Albrand, Solveig; Aleksa, Martin; Aleksandrov, Igor; Alessandria, Franco; Alexa, Calin; Alexander, Gideon; Alexandre, Gauthier; Alexopoulos, Theodoros; Alhroob, Muhammad; Aliev, Malik; Alimonti, Gianluca; Alison, John; Allbrooke, Benedict; Allport, Phillip; Allwood-Spiers, Sarah; Almond, John; Aloisio, Alberto; Alon, Raz; Alonso, Alejandro; Alonso, Francisco; Alvarez Gonzalez, Barbara; Alviggi, Mariagrazia; Amako, Katsuya; Amelung, Christoph; Ammosov, Vladimir; Amorim, Antonio; Amram, Nir; Anastopoulos, Christos; Ancu, Lucian Stefan; Andari, Nansi; Andeen, Timothy; Anders, Christoph Falk; Anders, Gabriel; Anderson, Kelby; Andreazza, Attilio; Andrei, George Victor; Anduaga, Xabier; Anger, Philipp; Angerami, Aaron; Anghinolfi, Francis; Anisenkov, Alexey; Anjos, Nuno; Annovi, Alberto; Antonaki, Ariadni; Antonelli, Mario; Antonov, Alexey; Antos, Jaroslav; Anulli, Fabio; Aoki, Masato; Aoun, Sahar; Aperio Bella, Ludovica; Apolle, Rudi; Arabidze, Giorgi; Aracena, Ignacio; Arai, Yasuo; Arce, Ayana; Arfaoui, Samir; Arguin, Jean-Francois; Arik, Engin; Arik, Metin; Armbruster, Aaron James; Arnaez, Olivier; Arnal, Vanessa; Arnault, Christian; Artamonov, Andrei; Artoni, Giacomo; Arutinov, David; Asai, Shoji; Asfandiyarov, Ruslan; Ask, Stefan; Å sman, Barbro; Asquith, Lily; Assamagan, Ketevi; Astbury, Alan; Aubert, Bernard; Auge, Etienne; Augsten, Kamil; Aurousseau, Mathieu; Avolio, Giuseppe; Avramidou, Rachel Maria; Axen, David; Azuelos, Georges; Azuma, Yuya; Baak, Max; Baccaglioni, Giuseppe; Bacci, Cesare; Bach, Andre; Bachacou, Henri; Bachas, Konstantinos; Backes, Moritz; Backhaus, Malte; Badescu, Elisabeta; Bagnaia, Paolo; Bahinipati, Seema; Bai, Yu; Bailey, David; Bain, Travis; Baines, John; Baker, Oliver Keith; Baker, Mark; Baker, Sarah; Banas, Elzbieta; Banerjee, Piyali; Banerjee, Swagato; Banfi, Danilo; Bangert, Andrea Michelle; Bansal, Vikas; Bansil, Hardeep Singh; Barak, Liron; Baranov, Sergei; Barbaro Galtieri, Angela; Barber, Tom; Barberio, Elisabetta Luigia; Barberis, Dario; Barbero, Marlon; Bardin, Dmitri; Barillari, Teresa; Barisonzi, Marcello; Barklow, Timothy; Barlow, Nick; Barnett, Bruce; Barnett, Michael; Baroncelli, Antonio; Barone, Gaetano; Barr, Alan; Barreiro, Fernando; Barreiro Guimarães da Costa, João; Barrillon, Pierre; Bartoldus, Rainer; Barton, Adam Edward; Bartsch, Valeria; Bates, Richard; Batkova, Lucia; Batley, Richard; Battaglia, Andreas; Battistin, Michele; Bauer, Florian; Bawa, Harinder Singh; Beale, Steven; Beau, Tristan; Beauchemin, Pierre-Hugues; Beccherle, Roberto; Bechtle, Philip; Beck, Hans Peter; Becker, Anne Kathrin; Becker, Sebastian; Beckingham, Matthew; Becks, Karl-Heinz; Beddall, Andrew; Beddall, Ayda; Bedikian, Sourpouhi; Bednyakov, Vadim; Bee, Christopher; Beemster, Lars; Begel, Michael; Behar Harpaz, Silvia; Beimforde, Michael; Belanger-Champagne, Camille; Bell, Paul; Bell, William; Bella, Gideon; Bellagamba, Lorenzo; Bellina, Francesco; Bellomo, Massimiliano; Belloni, Alberto; Beloborodova, Olga; Belotskiy, Konstantin; Beltramello, Olga; Benary, Odette; Benchekroun, Driss; Bendtz, Katarina; Benekos, Nektarios; Benhammou, Yan; Benhar Noccioli, Eleonora; Benitez Garcia, Jorge-Armando; Benjamin, Douglas; Benoit, Mathieu; Bensinger, James; Benslama, Kamal; Bentvelsen, Stan; Berge, David; Bergeaas Kuutmann, Elin; Berger, Nicolas; Berghaus, Frank; Berglund, Elina; Beringer, Jürg; Bernat, Pauline; Bernhard, Ralf; Bernius, Catrin; Berry, Tracey; Bertella, Claudia; Bertin, Antonio; Bertolucci, Federico; Besana, Maria Ilaria; Besjes, Geert-Jan; Besson, Nathalie; Bethke, Siegfried; Bhimji, Wahid; Bianchi, Riccardo-Maria; Bianco, Michele; Biebel, Otmar; Bieniek, Stephen Paul; Bierwagen, Katharina; Biesiada, Jed; Biglietti, Michela; Bilokon, Halina; Bindi, Marcello; Binet, Sebastien; Bingul, Ahmet; Bini, Cesare; Biscarat, Catherine; Bitenc, Urban; Black, Kevin; Blair, Robert; Blanchard, Jean-Baptiste; Blanchot, Georges; Blazek, Tomas; Blocker, Craig; Blocki, Jacek

    2013-01-01

    A measurement of the $\\Lambda_b^0$ lifetime and mass in the decay channel $\\Lambda_b^0 \\to J/\\psi(\\mu^+ \\mu^-) \\Lambda^0(p\\pi^-)$ is presented. The analysis uses a signal sample of about 2200 $\\Lambda_b^0$ and anti-Lambda_b decays that are reconstructed in 4.9 fb$^{-1}$ of ATLAS pp collision data collected in 2011 at the LHC center-of-mass energy of 7 TeV. A simultaneous mass and decay time maximum likelihood fit is used to extract the $\\Lambda_b^0$ lifetime and mass. They are measured to be $\\tau_{\\Lambda_b}$ = 1.449 +/- 0.036(stat) +/- 0.017(syst) ps and $m_{\\Lambda_b}$ = 5619.7 +/- 0.7(stat) +/- 1.1(syst) MeV.

  2. Bacteriophage therapy for safeguarding animal and human health: a review.

    Science.gov (United States)

    Tiwari, Ruchi; Dhama, Kuldeep; Kumar, Amit; Rahal, Anu; Kapoor, Sanjay

    2014-02-01

    Since the discovery of bacteriophages at the beginning of the 19th century their contribution to bacterial evolution and ecology and use in a variety of applications in biotechnology and medicine has been recognized and understood. Bacteriophages are natural bacterial killers, proven as best biocontrol agents due to their ability to lyse host bacterial cells specifically thereby helping in disease prevention and control. The requirement of such therapeutic approach is straight away required in view of the global emergence of Multidrug Resistant (MDR) strains of bacteria and rapidly developing resistance to antibiotics in both animals and humans along with increasing food safety concerns including of residual antibiotic toxicities. Phage typing is a popular tool to differentiate bacterial isolates and to identify and characterize outbreak-associated strains of Salmonella, Campylobacter, Escherichia and Listeria. Numerous methods viz. plaque morphology, ultracentrifugation in the density gradient of CsCl2, and random amplified polymorphic DNA (RAPD) have been found to be effective in detection of various phages. Bacteriophages have been isolated and recovered from samples of animal waste products of different livestock farms. High titer cocktails of broad spectrum lytic bacteriophages are usually used for clinical trial for assessing their therapeutic efficacy against antibiotic unresponsive infections in different animals. Bacteriophage therapy also helps to fight various bacterial infections of poultry viz. colibacillosis, salmonellosis and listeriosis. Moreover, the utility of phages concerning biosafety has raised the importance to explore and popularize the therapeutic dimension of this promising novel therapy which forms the topic of discussion of the present review.

  3. Bacteriophages as an alternative strategy for fighting biofilm development.

    Science.gov (United States)

    Parasion, Sylwia; Kwiatek, Magdalena; Gryko, Romuald; Mizak, Lidia; Malm, Anna

    2014-01-01

    The ability of microbes to form biofilms is an important element of their pathogenicity, and biofilm formation is a serious challenge for today's medicine. Fighting the clinical complications associated with biofilm formation is very difficult and linked to a high risk of failure, especially in a time of increasing bacterial resistance to antibiotics. Bacterial species most commonly isolated from biofilms include coagulase-negative staphylococci, Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter spp. The frequent failure of antibiotic therapy led researchers to look for alternative methods and experiment with the use of antibacterial factors with a mechanism of action different from that of antibiotics. Experimental studies with bacteriophages and mixtures thereof, expressing lytic properties against numerous biofilm-forming bacterial species showed that bacteriophages may both prevent biofilm formation and contribute to eradication of biofilm bacteria. A specific role is played here by phage depolymerases, which facilitate the degradation of extracellular polymeric substances (EPS) and thus the permeation of bacteriophages into deeper biofilm layers and lysis of the susceptible bacterial cells. Much hope is placed in genetic modifications of bacteriophages that would allow the equipping bacteriophages with the function of depolymerase synthesis. The use of phage cocktails prevents the development of phage-resistant bacteria.

  4. Alternative bacteriophage life cycles: the carrier state of Campylobacter jejuni.

    Science.gov (United States)

    Siringan, Patcharin; Connerton, Phillippa L; Cummings, Nicola J; Connerton, Ian F

    2014-01-01

    Members of the genus Campylobacter are frequently responsible for human enteric disease, often through consumption of contaminated poultry products. Bacteriophages are viruses that have the potential to control pathogenic bacteria, but understanding their complex life cycles is key to their successful exploitation. Treatment of Campylobacter jejuni biofilms with bacteriophages led to the discovery that phages had established a relationship with their hosts typical of the carrier state life cycle (CSLC), where bacteria and bacteriophages remain associated in equilibrium. Significant phenotypic changes include improved aerotolerance under nutrient-limited conditions that would confer an advantage to survive in extra-intestinal environments, but a lack in motility eliminated their ability to colonize chickens. Under these circumstances, phages can remain associated with a compatible host and continue to produce free virions to prospect for new hosts. Moreover, we demonstrate that CSLC host bacteria can act as expendable vehicles for the delivery of bacteriophages to new host bacteria within pre-colonized chickens. The CSLC represents an important phase in the ecology of Campylobacter bacteriophage. PMID:24671947

  5. Sequence variability of Campylobacter temperate bacteriophages

    Directory of Open Access Journals (Sweden)

    Ng Lai-King

    2008-03-01

    Full Text Available Abstract Background Prophages integrated within the chromosomes of Campylobacter jejuni isolates have been demonstrated very recently. Prior work with Campylobacter temperate bacteriophages, as well as evidence from prophages in other enteric bacteria, suggests these prophages might have a role in the biology and virulence of the organism. However, very little is known about the genetic variability of Campylobacter prophages which, if present, could lead to differential phenotypes in isolates carrying the phages versus those that do not. As a first step in the characterization of C. jejuni prophages, we investigated the distribution of prophage DNA within a C. jejuni population assessed the DNA and protein sequence variability within a subset of the putative prophages found. Results Southern blotting of C. jejuni DNA using probes from genes within the three putative prophages of the C. jejuni sequenced strain RM 1221 demonstrated the presence of at least one prophage gene in a large proportion (27/35 of isolates tested. Of these, 15 were positive for 5 or more of the 7 Campylobacter Mu-like phage 1 (CMLP 1, also designated Campylobacter jejuni integrated element 1, or CJIE 1 genes tested. Twelve of these putative prophages were chosen for further analysis. DNA sequencing of a 9,000 to 11,000 nucleotide region of each prophage demonstrated a close homology with CMLP 1 in both gene order and nucleotide sequence. Structural and sequence variability, including short insertions, deletions, and allele replacements, were found within the prophage genomes, some of which would alter the protein products of the ORFs involved. No insertions of novel genes were detected within the sequenced regions. The 12 prophages and RM 1221 had a % G+C very similar to C. jejuni sequenced strains, as well as promoter regions characteristic of C. jejuni. None of the putative prophages were successfully induced and propagated, so it is not known if they were functional or

  6. Quark to $\\Lambda$-hyperon spin transfers in the current-fragmentation region

    OpenAIRE

    Chi, Yujie; Ma, Bo-Qiang

    2013-01-01

    We perform a study on the struck quark to the $\\Lambda$-hyperon fragmentation processes by taking into account the anti-quark fragmentations and intermediate decays from other hyperons. We concentrate on how the longitudinally polarized quark fragments to the longitudinally polarized $\\Lambda$, how unpolarized quark and anti-quark fragment to the unpolarized $\\Lambda$, and how quark and anti-quark fragment to the $\\Lambda$ through the intermediate decay processes. We calculate the effective f...

  7. On the role of Cro in lambda prophage induction

    DEFF Research Database (Denmark)

    Svenningsen, Sine Lo; Constantino, Nina; Court, Donald L;

    2005-01-01

    The lysogenic state of bacteriophage ¿ is exceptionally stable yet the prophage is readily induced in response to DNA damage. This delicate epigenetic switch is believed to be regulated by two proteins; the lysogenic maintenance promoting protein CI and the early lytic protein Cro. First, we conf...... of the cro gene might be unimportant for the lysogenic to lytic switch during induction of the ¿ prophage. We revisit the idea that Cro's primary role in induction is instead to mediate weak repression of the early lytic promoters....

  8. Measurements of $\\Lambda^+_c$ Branching Fractions of Cabibbo-Suppressed Decay Modes

    CERN Document Server

    Aubert, B; Abrams, G S; Adye, T; Ahmed, S; Alam, M S; Albert, J; Aleksan, Roy; Allison, J; Allmendinger, T; Altenburg, D; Andreotti, M; Angelini, C; Anulli, F; Aston, D; Azzolini, V; Baak, M; Back, J J; Bailey, S; Baldini-Ferroli, R; Band, H R; Banerjee, Sw; Barate, R; Bard, D J; Barlow, N R; Barlow, R J; Barrett, M; Bartoldus, R; Batignani, G; Bauer, J M; Beck, T W; Bellini, F; Benayoun, M; Berger, N; Bernard, D; Berryhill, J W; Best, D; Bettarini, S; Bettoni, D; Bevan, A J; Bhimji, W; Bianchi, F; Biasini, M; Blanc, F; Blaylock, G; Blinov, A E; Blinov, V E; Bloom, P; Bóna, M; Bondioli, M; Bonneaud, G R; Borgland, A W; Bosisio, L; Boutigny, D; Bowerman, D A; Boyarski, A M; Boyd, J T; Bozzi, C; Brandenburg, G; Brandt, T; Brau, J E; Breon, A B; Briand, H; Brochard, F; Brose, J; Brown, C L; Brown, C M; Brown, D; Brown, D N; Bruinsma, M; Brunet, S; Bucci, F; Buchanan, C; Buchmüller, O L; Bulten, H; Burchat, Patricia R; Button-Shafer, J; Buzzo, A; Côté, D; Cahn, R N; Calabrese, R; Calcaterra, A; Calderini, G; Campagnari, C; Capra, R; Carpinelli, M; Cartaro, C; Cavallo, N; Cavoto, G; Chaisanguanthum, K S; Chao, M; Charles, E; Charles, M J; Chauveau, J; Chavez, C A; Chen, A; Chen, E; Chen, J C; Chen, S; Cheng, B; Cheng, C H; Chevalier, N; Christ, S; Cibinetto, G; Clark, P J; Claus, R; Cochran, J; Colecchia, F; Coleman, J P; Contri, R; Convery, M R; Cormack, C M; Cossutti, F; Cottingham, W N; Couderc, F; Covarelli, R; Cowan, G; Crawley, H B; Cremaldi, L M; Cristinziani, M; Crosetti, G; Çuhadar-Dönszelmann, T; Dahmes, B; Dallapiccola, C; Danielson, N; Dasu, S; Datta, M; Dauncey, P D; David, P; Davier, M; Davis, C L; Day, C T; De Groot, N; De Nardo, Gallieno; Del Buono, L; Della Ricca, G; Di Lodovico, F; Dickopp, M; Dittongo, S; Dong, D; Dorfan, J; Dorigo, A; Druzhinin, V P; Dubois-Felsmann, G P; Dujmic, D; Dunwoodie, W M; Dvoretskii, A; Eckmann, R; Edwards, A J; Egede, U; Eichenbaum, A M; Eigen, G; Eisner, A M; Elmer, P; Elsen, E E; Emery, S; Ernst, J A; Eschenburg, V; Eschrich, I; Fabozzi, F; Faccini, R; Fan, S; Farbin, A; Feltresi, E; Ferrarotto, F; Ferroni, F; Field, R C; Finocchiaro, G; Flack, R L; Flächer, H U; Flood, K T; Ford, K E; Ford, W T; Forster, I J; Forti, F; Fortin, D; Foulkes, S D; Franek, B J; Frey, R; Fritsch, M; Fry, J R; Gabathuler, Erwin; Gaidot, A; Gaillard, J M; Gaillard, J R; Galeazzi, F; Gallo, F; Gamba, D; Gamet, R; Gan, K K; Ganzhur, S F; Gary, J W; Gaspero, M; Gatto, C; Geddes, N I; Gill, M S; Giorgi, M A; Giraud, P F; Giroux, X; Gladney, L; Glanzman, T; Godang, R; Goetzen, K; Golubev, V B; Gopal, G P; Gowdy, S J; Graham, M; Grancagnolo, S; Green, M G; Greene, M G; Grenier, G J; Grenier, P; Gritsan, A V; Grosdidier, G; Groysman, Y; Guo, Q H; Hadavand, H K; Hadig, T; Haire, M; Halyo, V; Hamel de Monchenault, G; Hamon, O; Harrison, P F; Harrison, T J; Hart, A J; Hart, P A; Hartfiel, B L; Harton, J L; Hast, C; Hauke, A; Hawkes, C M; Hearty, C; Held, T; Hertzbach, S S; Heusch, C A; Hicheur, A; Hill, E J; Hitlin, D G; Höcker, A; Hodgkinson, M C; Hollar, J J; Honscheid, K; Hrynóva, T; Hufnagel, D; Hulsbergen, W D; Hutchcroft, D E; Igonkina, O; Innes, W R; Ivanchenko, V N; Izen, J M; Jackson, P D; Jackson, P S; Jacobsen, R G; Jawahery, A; Jayatilleke, S M; Jessop, C P; John, M J J; Johnson, J R; Judd, D; Kadel, R W; Kadyk, J; Kagan, H; Karyotakis, Yu; Kass, R; Kelly, M P; Kelsey, M H; Kerth, L T; Khan, A; Kim, H; Kim, P; Kirkby, D; Kitayama, I; Knecht, N S; Koch, H; Kocian, M L; Kofler, R; Kolomensky, Yu G; Koptchev, V B; Kovalskyi, D; Kowalewski, R V; Kozanecki, Witold; Kravchenko, E A; Krishnamurthy, M; Kroeger, R; Kroseberg, J; Kukartsev, G; Kutter, P E; Kyberd, P; Lacker, H M; Lae, C K; Lafferty, G D; Lamsa, J; Lanceri, L; Lange, D J; Langenegger, U; Lankford, A J; Laplace, S; Latham, T E; Lau, Y P; Lavin, D; Lazzaro, A; Le Diberder, F R; Lees, J P; Legendre, M; Leith, D W G S; Lepeltier, V; Leruste, P; Lewandowski, B; Li Gioi, L; Li, H; Libby, J; Lillard, V; Lista, L; Liu, R; LoSecco, J M; Lo Vetere, M; Lockman, W S; Lombardo, V; London, G W; Long, O; Lou, X C; Lu, A; Lü, C; Luitz, S; Luppi, E; Lusiani, A; Lüth, V; Lutz, A M; Lynch, G; Lynch, H L; Lyon, A J; MacFarlane, D B; Macri, M; Malcles, J; Mallik, U; Mancinelli, G; Mandelkern, M A; Manfredi, P F; Mangeol, D J J; Marchiori, G; Margoni, M; Marsiske, H; Martínez-Vidal, F; Mattison, T S; Mayer, B; Mazur, M A; Mazzoni, M A; McKenna, J A; McMahon, T R; Meadows, B T; Messner, R; Meyer, T I; Meyer, W T; Miftakov, V; Mihályi, A; Mir, L M; Mohanty, G B; Mohapatra, A K; Mommsen, R K; Monge, M R; Monorchio, D; Moore, T B; Morandin, M; Morgan, S E; Morganti, M; Morganti, S; Morii, M; Morton, G W; Muheim, F; Müller, D R; Müller-Pfefferkorn, R; Narsky, I; Nash, J A; Nauenberg, U; Neal, H; Negrini, M; Neri, N; Nesom, G; Nicholson, H; Nikolich, M B; Nogowski, R; O'Grady, C P; Ocariz, J; Oddone, P J; Ofte, I; Olaiya, E O; Olivas, A; Olsen, J; Onuchin, A P; Orimoto, T J; Otto, S; Ozcan, V E; Paar, H P; Paick, K; Palano, A; Palombo, F; Pan, Y; Panetta, J; Panvini, R S; Paoloni, E; Paolucci, P; Parry, R J; Passaggio, S; Patel, P M; Patrignani, C; Patteri, P; Payne, D J; Pelizaeus, M; Perazzo, A; Perl, M; Peruzzi, I M; Petersen, B A; Petersen, T C; Petrak, S; Petzold, A; Piatenko, T; Piccolo, D; Piccolo, M; Piemontese, L; Pierini, M; Pioppi, M; Piredda, G; Pivk, M; Plaszczynski, S; Playfer, S; Pompili, A; Poropat, P; Porter, F C; Posocco, M; Potter, C T; Prell, S; Prepost, R; Pripstein, M; Pulliam, T; Purohit, M V; Qi, N D; Rahatlou, S; Rahimi, A M; Rama, M; Rankin, P; Ratcliff, B N; Raven, G; Re, V; Reidy, J; Ricciardi, S; Richman, J D; Ritchie, J L; Rizzo, G; Roat, C; Roberts, D A; Robertson, S H; Robutti, E; Roe, N A; Röthel, W; Ronan, Michael T; Roney, J M; Rong, G; Roodman, A; Roos, L; Rosenberg, E I; Rotondo, M; Rubin, A E; Ryd, A; Saeed, M A; Safai-Tehrani, F; Saleem, M; Salnikov, A A; Salvatore, F; Samuel, A; Sanders, D A; Sandrelli, F; Santroni, A; Saremi, S; Sarti, A; Satpathy, A; Schalk, T; Schindler, R H; Schott, G; Schrenk, S; Schubert, J; Schubert, Klaus R; Schumm, B A; Schune, M H; Schwiening, J; Schwierz, R; Schwitters, R F; Sciacca, C; Sciolla, G; Seiden, A; Sekula, S J; Serednyakov, S I; Sharma, V; Shelkov, V G; Shen, B C; Simani, M C; Simi, G; Simonetto, F; Sinev, N B; Skovpen, Yu I; Sloane, R J; Smith, A J S; Smith, J G; Snoek, H L; Snyder, A; Sobie, R J; Soffer, A; Soha, A; Sokoloff, M D; Solodov, E P; Spaan, B; Spanier, S M; Spradlin, P; Stängle, H; Steinke, M; Stelzer, J; Stoker, D P; Stroili, R; Strom, D; Stugu, B; Su, D; Sullivan, M K; Summers, D J; Sundermann, J E; T'Jampens, S; Tan, P; Tantot, L; Taras, P; Taylor, F; Taylor, G P; Telnov, A V; Teodorescu, L; Ter-Antonian, R; Therin, G; Thiebaux, C; Thiessen, D; Tiozzo, G; Tisserand, V; Toki, W H; Torrence, E; Tosi, S; Touramanis, C; Treadwell, E; Vasileiadis, G; Vasseur, G; Vavra, J; Verderi, M; Verkerke, W; Vitale, L; Voci, C; Voena, C; Vuagnin, G; Wagner, G; Wagner, S R; Wagoner, D E; Waldi, R; Walsh, J; Wang, K; Wang, P; Wappler, F R; Watson, A T; Weaver, M; Weidemann, A W; Weinstein, A J R; Wenzel, W A; Wilden, L; Williams, D C; Williams, J C; Willocq, S; Wilson, F F; Wilson, J R; Wilson, M G; Wilson, R J; Winter, M A; Wisniewski, W J; Wittgen, M; Won, E; Wong, Q K; Wormser, G; Wright, D H; Wright, D M; Wu, J; Wu, S L; Xie, Y; Yamamoto, R K; Yang, S; Yarritu, A K; Ye, S; Yéche, C; Yi, J; Young, C C; Yu, Z; Yumiceva, F X; Yushkov, A N; Zallo, A; Zeng, Q; Zghiche, A; Zhang, J; Zhang, L; Zhao, H W; Zhu, Y S; Zito, M; De Sangro, R; La Vaissière, C de

    2004-01-01

    We have measured the branching fractions of the Cabibbo-suppressed decays $\\Lambda^+_c$ $\\to$ $\\Lambda^{0}$ $K^+$ and $\\Lambda^+_c$ $\\to$ $\\Sigma^0$ $K^+$ %(measured with improved accuracy). relative to the Cabibbo-allowed decay modes $\\Lambda^+_c$ $\\to$ $\\Lambda^{0}$ $\\pi^+$ and $\\Lambda^+_c$ $\\to$ $\\Sigma^0$ $\\pi^+$ to be $ 0.044 \\pm 0.004 (\\textnormal{stat.}) \\pm 0.002 (\\textnormal{syst.})$ and $ 0.040 \\pm 0.005 (\\textnormal{stat.}) \\pm 0.004 (\\textnormal{syst.})$, respectively. We also present the first observation of $\\Lambda^+_c$ $\\to$ $\\Lambda^{0}$ $K^+ \\pi^+ \\pi^-$ and have measured the branching fraction relative to $\\Lambda^+_c$ $\\to$ $\\Lambda^{0}$ $\\pi^+$ to be $0.266 \\pm 0.027 (\\textnormal{stat.}) \\pm 0.032 (\\textnormal{syst.})$. The upper limit of the branching fraction into the decay $\\Lambda^+_c$ $\\to$ $\\Sigma^0$ $K^+ \\pi^+ \\pi^-$ relative to $\\Lambda^+_c$ $\\to$ $\\Sigma^0$ $\\pi^+$ has been measured to be %7.6 \\times 10^{-4}$ $ < 3.9 \\times 10^{-2}$ at the 90% confidence level. This analysis ...

  9. Charge symmetry breaking in $\\Lambda$ hypernuclei: updated HYP 2015 progress report

    CERN Document Server

    Gal, Avraham

    2016-01-01

    Ongoing progress in understanding and evaluating charge symmetry breaking in $\\Lambda$ hypernuclei is discussed in connection to recent measurements of the $_{\\Lambda}^{4}{\\rm H}(0^+_{\\rm g.s.})$ binding energy at MAMI [A1 Collaboration: PRL 114 (2015) 232501] and of the $_{\\Lambda}^{4}{\\rm He}(1^+_{\\rm exc})$ excitation energy at J-PARC [E13 Collaboration: PRL 115 (2015) 222501].

  10. Semileptonic decays of $\\Lambda_c$ baryons in the relativistic quark model

    CERN Document Server

    Faustov, R N

    2016-01-01

    Motivated by recent experimental progress in studying weak decays of the $\\Lambda_c$ baryon we investigate its semileptonic decays in the framework of the relativistic quark model based on the quasipotential approach and QCD. The form factors of the $\\Lambda_c\\to \\Lambda l\

  11. Polarization of Lambda0 and antiLambda0 inclusively produced by 610GeV/c Sigma- and 525GeV/c proton beams

    CERN Document Server

    Sanchez-Lopez, J L; Engelfried, J; Akgun, U; Alkhazov, G; Amaro-Reyes, J; Atamanchuk, A G; Ayan, A S; Balatz, M Y; Blanco-Covarrubias, A; Bondar, N F; Cooper, P S; Dauwe, L J; Davidenko, G V; Dersch, U; Dolgolenko, A G; Dzyubenko, G B; Edelstein, R; Emediato, L; Endler, A M F; Eschrich, I; Escobar, C O; Estrada, N; Evdokimov, A V; Filimonov, I S; Flores-Castillo, A; García, F G; Gaspero, M; Giller, I; Golovtsov, V L; Gouffon, P; Gülmez, E; He Kangling; Iori, M; Jun, S Y; Kaya, M; Kilmer, J; Kim, V T; Kochenda, L M; Konorov, I; Kozhevnikov, A P; Krivshich, A G; Krüger, H; Kubantsev, M A; Kubarovskii, V P; Kulyavtsev, A I; Kuropatkin, N P; Kurshetsov, V F; Kushnirenko, A; Kwan, S; Lach, J; Lamberto, A; Landsberg, L G; Larin, I; Leikin, E M; Li Yunshan; Luksys, M; Lungov, T; Maleev, V P; Mao, D; Mao, Chensheng; Mao, Zhenlin; Mathew, P; Mattson, M; Matveev, V; McCliment, E; Moinester, M A; Molchanov, V V; Morelos, A; Nemitkin, A V; Neoustroev, P V; Newsom, C; Nilov, A P; Nurushev, S B; Ocherashvili, A; Onel, Y; Ozel, E; Ozkorucuklu, S; Penzo, Aldo L; Petrenko, S V; Pogodin, P I; Procario, M; Prutskoi, V A; Ramberg, E; Rappazzo, G F; Razmyslovich, B V; Rud, V I; Russ, J; Schiavon, Paolo; Simón, J; Sitnikov, A I; Skow, D; Smith, V J; Srivastava, M; Steiner, V; Stepanov, V; Stutte, L; Svoiski, M; Terentyev, N K; Thomas, G P; Torres, I; Uvarov, L N; Vasilev, A N; Vavilov, D V; Vazquez-Jauregui, E; Verebryusov, V S; Victorov, V A; Vishnyakov, V E; Vorobyov, A A; Vorwalter, K; You, J; Zhao, Wenheng; Zheng, Shuchen; Zukanovich-Funchal, R

    2007-01-01

    We have measured the polarization of Lambda0 and antiLambda0 inclusively produced by 610GeV/c Sigma- and 525GeV/c proton beams in the experiment SELEX during the 1996/7 fixed target run at Fermilab. The polarization was measured as a function of the Lambda longitudinal momentum fraction xF and transverse momentum pt. For the Lambda0 produced by Sigma- the polarization is increasing with xF, from slightly negative at x_F~0 to about 15% at large xF; it shows a non-monotonic behavior as a function of pt. For the proton beam, the Lambda0 polarization is negative and decreasing as a function of xF and pt. The antiLambda0 polarization is compatible with 0 for both beam particles over the full kinematic range. The target dependence was examined but no statistically significant difference was found.

  12. Bacteriophage based probes for pathogen detection.

    Science.gov (United States)

    Singh, Amit; Arutyunov, Denis; Szymanski, Christine M; Evoy, Stephane

    2012-08-01

    Rapid and specific detection of pathogenic bacteria is important for the proper treatment, containment and prevention of human, animal and plant diseases. Identifying unique biological probes to achieve a high degree of specificity and minimize false positives has therefore garnered much interest in recent years. Bacteriophages are obligate intracellular parasites that subvert bacterial cell resources for their own multiplication and production of disseminative new virions, which repeat the cycle by binding specifically to the host surface receptors and injecting genetic material into the bacterial cells. The precision of host recognition in phages is imparted by the receptor binding proteins (RBPs) that are often located in the tail-spike or tail fiber protein assemblies of the virions. Phage host recognition specificity has been traditionally exploited for bacterial typing using laborious and time consuming bacterial growth assays. At the same time this feature makes phage virions or RBPs an excellent choice for the development of probes capable of selectively capturing bacteria on solid surfaces with subsequent quick and automatic detection of the binding event. This review focuses on the description of pathogen detection approaches based on immobilized phage virions as well as pure recombinant RBPs. Specific advantages of RBP-based molecular probes are also discussed.

  13. Interplay Between Bacteriophages and Restriction-Modification Systems in Enterococci

    Directory of Open Access Journals (Sweden)

    Pristas Peter

    2014-06-01

    Full Text Available The complete genomes of Enterococcus faecalis bacteriophages were analyzed for tetranucleotide words avoidance. Very similar tetranucleotide composition was found in all tested genomes with strong underrepresentation of palindromic GATC and GGCC words. This avoidance could be explained as a protection mechanism against host restriction-modification systems as a clear correlation was found between avoidance of palindromic words and the specificity of E. faecalis restriction and modification systems. No similar avoidance of tetranucleotide words was observed for non-palindromic words. A weak correlation was observed between avoidance of tetranucleotide palindromes in bacteriophage genomes and the possession of phage encoded DNA methyltransferases confirming the interrelation between bacteriophage genomes composition and restriction and modification systems in enterococci

  14. A quorum-sensing-induced bacteriophage defense mechanism

    DEFF Research Database (Denmark)

    Høyland-Kroghsbo, Nina Molin; Mærkedahl, Rasmus Baadsgaard; Svenningsen, Sine

    2013-01-01

    One of the key determinants of the size, composition, structure, and development of a microbial community is the predation pressure by bacteriophages. Accordingly, bacteria have evolved a battery of antiphage defense strategies. Since maintaining constantly elevated defenses is costly, we...... understanding of the factors that naturally shape microbial communities is required. One of the key factors in this context is the interactions between bacteria and the most abundant biological entities on Earth, namely, the bacteriophages that prey on bacteria. This proof-of-principle study shows that quorum...... sensing plays an important role in determining the susceptibility of E. coli to infection by bacteriophages ¿ and ¿. On the basis of our findings in the classical Escherichia coli-¿ model system, we suggest that quorum sensing may serve as a general strategy to protect bacteria specifically under...

  15. Bacteriophages as potential treatment option for antibiotic resistant bacteria.

    Science.gov (United States)

    Bragg, Robert; van der Westhuizen, Wouter; Lee, Ji-Yun; Coetsee, Elke; Boucher, Charlotte

    2014-01-01

    The world is facing an ever-increasing problem with antibiotic resistant bacteria and we are rapidly heading for a post-antibiotic era. There is an urgent need to investigate alterative treatment options while there are still a few antibiotics left. Bacteriophages are viruses that specifically target bacteria. Before the development of antibiotics, some efforts were made to use bacteriophages as a treatment option, but most of this research stopped soon after the discovery of antibiotics. There are two different replication options which bacteriophages employ. These are the lytic and lysogenic life cycles. Both these life cycles have potential as treatment options. There are various advantages and disadvantages to the use of bacteriophages as treatment options. The main advantage is the specificity of bacteriophages and treatments can be designed to specifically target pathogenic bacteria while not negatively affecting the normal microbiota. There are various advantages to this. However, the high level of specificity also creates potential problems, the main being the requirement of highly specific diagnostic procedures. Another potential problem with phage therapy includes the development of immunity and limitations with the registration of phage therapy options. The latter is driving research toward the expression of phage genes which break the bacterial cell wall, which could then be used as a treatment option. Various aspects of phage therapy have been investigated in studies undertaken by our research group. We have investigated specificity of phages to various avian pathogenic E. coli isolates. Furthermore, the exciting NanoSAM technology has been employed to investigate bacteriophage replication and aspects of this will be discussed.

  16. Bacteriophages as potential treatment option for antibiotic resistant bacteria.

    Science.gov (United States)

    Bragg, Robert; van der Westhuizen, Wouter; Lee, Ji-Yun; Coetsee, Elke; Boucher, Charlotte

    2014-01-01

    The world is facing an ever-increasing problem with antibiotic resistant bacteria and we are rapidly heading for a post-antibiotic era. There is an urgent need to investigate alterative treatment options while there are still a few antibiotics left. Bacteriophages are viruses that specifically target bacteria. Before the development of antibiotics, some efforts were made to use bacteriophages as a treatment option, but most of this research stopped soon after the discovery of antibiotics. There are two different replication options which bacteriophages employ. These are the lytic and lysogenic life cycles. Both these life cycles have potential as treatment options. There are various advantages and disadvantages to the use of bacteriophages as treatment options. The main advantage is the specificity of bacteriophages and treatments can be designed to specifically target pathogenic bacteria while not negatively affecting the normal microbiota. There are various advantages to this. However, the high level of specificity also creates potential problems, the main being the requirement of highly specific diagnostic procedures. Another potential problem with phage therapy includes the development of immunity and limitations with the registration of phage therapy options. The latter is driving research toward the expression of phage genes which break the bacterial cell wall, which could then be used as a treatment option. Various aspects of phage therapy have been investigated in studies undertaken by our research group. We have investigated specificity of phages to various avian pathogenic E. coli isolates. Furthermore, the exciting NanoSAM technology has been employed to investigate bacteriophage replication and aspects of this will be discussed. PMID:24619620

  17. Quark confinement potential examined by excitation energy of the Lambda_c and Lambda_b baryons in a quark-diquark model

    CERN Document Server

    Jido, Daisuke

    2016-01-01

    The possibility to have diquark configuration in heavy baryons, such as Lambda_c and Lambda_b, is examined by a nonrelativistic potential model with a heavy quark and a light scalar diquark. Assuming that the Lambda_c and Lambda_b baryons are composed of the heavy quark and the scalar-isoscalar ud diquark, we solve the two-body Schrodinger equation with the Coulomb plus linear potential and obtain the energy spectra for the heavy baryons. Contrary to our expectation, it is found that the potential determined by the quarkonium spectra fails to reproduce the excitation spectra of the Lambda_c and Lambda_b in the quark-diquark picture, while the Lambda_c and Lambda_b spectra is reproduced with a half strength of the confinement string tension than for the quarkonium. The Xi_c excitation energy is also calculated and is found to be smaller than Lambda_c in the quark-diquark model. This is not consistent with the experimental observation. These puzzles should be solved when one takes the quark-diquark picture for ...

  18. Stable carbon isotope fractionation during the biodegradation of lambda-cyhalothrin

    Energy Technology Data Exchange (ETDEWEB)

    Shen, Xiaoli [MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058 (China); Department of Environmental Engineering, Quzhou University, Quzhou 324000 (China); Xu, Zemin [MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058 (China); Zhang, Xichang [Laboratory for Teaching in Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058 (China); Yang, Fangxing, E-mail: fxyang@zju.edu.cn [MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058 (China); Department of Effect-Directed Analysis, Helmholtz Centre for Environmental Research — UFZ, Leipzig 04318 (Germany)

    2015-11-01

    In this study, the microbial degradation of lambda-cyhalothrin in soil was investigated using compound-specific stable isotope analysis. The results revealed that lambda-cyhalothrin was biodegraded in soil under laboratory conditions. The half-lives of lambda-cyhalothrin were determined to be 49 and 161 days in non-sterile and sterile soils spiked with 2 mg/kg lambda-cyhalothrin and 84 and 154 days in non-sterile and sterile soils spiked with 10 mg/kg lambda-cyhalothrin, respectively. The biodegradation of lambda-cyhalothrin resulted in carbon isotope fractionation, which shifted from − 29.0‰ to − 26.5‰ in soil spiked with 2 mg/kg lambda-cyhalothrin, and to − 27.5‰ with 10 mg/kg lambda-cyhalothrin. A relationship was established between the stable carbon isotope fraction and the residual concentrations of lambda-cyhalothrin by the Rayleigh equation in which the carbon isotope enrichment factor ε of the microbial degradation of lambda-cyhalothrin in the soil was calculated as − 2.53‰. This study provides an approach to quantitatively evaluate the biodegradation of lambda-cyhalothrin in soil in field studies. - Highlights: • Abiotic and biotic degradation of lambda-cyhalothrin were observed in soil. • Biodegradation of lambda-cyhalothrin was evaluated by CSIA. • Biodegradation of lambda-cyhalothrin leads to carbon isotope fractionation. • An enrichment factor ε of lambda-cyhalothrin was determined as − 2.53‰.

  19. Ultracompact radio sources-data and a variable $\\Lambda$

    CERN Document Server

    Vishwakarma, R G

    1999-01-01

    In order to test the consistency of the cosmological models with observations as well as to measure the different cosmological parameters, data on angular sizes and reshifts of ultracompact radio sources, compiled by Jackson and Dodgson, has been used recently by several authors in the models with constant to solve the cosmological constant problem, we examine this data for a variable fluid flow which demands $\\Lambda$ to be variable. We find that the acceptable fits are also obtained for open models with small $\\Lambda$ of either sign. The models are found to be decelerating and require intermediate density, higher than that in the models of Jackson and Dodgson but not as high as in the cannonical cold dark matter model of Kellermann.

  20. Looking Beyond Lambda with the Union Supernova Compilation

    CERN Document Server

    Rubin, D; Kowalski, M; Aldering, G; Amanullah, R; Barbary, K; Connolly, N V; Dawson, K S; Faccioli, L; Fadeev, V; Goldhaber, G; Goobar, A; Hook, I; Lidman, C; Meyers, J; Nobili, S; Nugent, P E; Pain, R; Perlmutter, S; Ruiz-Lapuente, P; Spadafora, A L; Strovink, M; Suzuki, N; Swift, H

    2008-01-01

    The recent robust and homogeneous analysis of the world's supernova distance-redshift data, together with cosmic microwave background and baryon acoustic oscillation data, provides a powerful tool for constraining cosmological models. Here we examine particular classes of scalar field, modified gravity, and phenomenological models to assess whether they are consistent with observations even when their behavior deviates from the cosmological constant Lambda. Some models have tension with the data, while others survive only by approaching the cosmological constant, and a couple are statistically favored over LCDM. Dark energy described by two equation of state parameters has considerable phase space to avoid Lambda and next generation data will be required to constrain such physics.

  1. Modeling and Simulation of Photoelectronic Lambda Bipolar Transistor

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Based on the region model of lambda bipolar transistor (LBT), a dividing region theory model of PLBT is set up,simulated and verified. Firstly, the principal operations of different kinds of photoelectronic lambda bipolar transistor (PLBT) are characterized by a simple circuit model.Through mathematical analysis of the equivalent circuit, the typical characteristics curve is divided into positive resistance, peak, negative resistance and cutoff regions. Secondly, by analyzing and simulating this model, the ratio of MOSFET width to channel length, threshold voltage and common emitter gain are discovered as the main structure parameters that determine the characteristic curves of PLBT. And peak region width, peak current value, negative resistance value and valley voltage value of PLBT can be changed conveniently according to the actual demands by modifying these parameters. Finally comparisons of the characteristics of the fabricated devices and the simulation results are made, which show that the analytical results are in agreement with the observed devices characteristics.

  2. Beyond $\\Lambda$CDM: Problems, solutions, and the road ahead

    CERN Document Server

    Bull, Philip; Adamek, Julian; Baker, Tessa; Bellini, Emilio; Jiménez, Jose Beltrán; Bentivegna, Eloisa; Camera, Stefano; Clesse, Sébastien; Davis, Jonathan H; Di Dio, Enea; Enander, Jonas; Finelli, Fabio; Heavens, Alan; Heisenberg, Lavinia; Hu, Bin; Llinares, Claudio; Maartens, Roy; Mörtsell, Edvard; Nadathur, Seshadri; Noller, Johannes; Pasechnik, Roman; Pawlowski, Marcel S; Pereira, Thiago S; Quartin, Miguel; Ricciardone, Angelo; Riemer-Sørensen, Signe; Rinaldi, Massimiliano; Sakstein, Jeremy; Saltas, Ippocratis D; Salzano, Vincenzo; Sawicki, Ignacy; Solomon, Adam R; Spolyar, Douglas; Starkman, Glenn D; Steer, Danièle; Tereno, Ismael; Verde, Licia; Villaescusa-Navarro, Francisco; von Strauss, Mikael; Winther, Hans A

    2015-01-01

    Despite its continued observational successes, there is a persistent (and growing) interest in extending cosmology beyond the standard model, $\\Lambda$CDM. This is motivated by a range of apparently serious theoretical issues, involving such questions as the cosmological constant problem, the particle nature of dark matter, the validity of general relativity on large scales, the existence of anomalies in the CMB and on small scales, and the predictivity and testability of the inflationary paradigm. In this paper, we summarize the current status of $\\Lambda$CDM as a physical theory, and review investigations into possible alternatives along a number of different lines, with a particular focus on highlighting the most promising directions. While the fundamental problems are proving reluctant to yield, the study of alternative cosmologies has led to considerable progress, with much more to come if hopes about forthcoming high-precision observations and new theoretical ideas are fulfilled.

  3. Which spectral distortions does $\\Lambda$CDM actually predict?

    CERN Document Server

    Chluba, Jens

    2016-01-01

    Ever refined cosmological measurements have established the $\\Lambda$CDM concordance model, with the key cosmological parameters being determined to percent-level precision today. This allows us to make explicit predictions for the spectral distortions of the cosmic microwave background (CMB) created by various processes occurring in the early Universe. Here, we summarize all guaranteed CMB distortions and assess their total uncertainty within $\\Lambda$CDM. We also compare simple methods for approximating them, highlighting some of the subtle aspects when it comes to interpreting future distortion measurements. Under simplified assumptions, we briefly study how well a PIXIE-like experiment may measure the main distortion parameters (i.e., $\\mu$ and $y$). Next generation CMB spectrometers are expected to detect the distortion caused by reionization and structure formation at extremely high significance. They will also be able to constrain the small-scale power spectrum through the associated $\\mu$-distortion, ...

  4. Lambda-antilambda decay asymmetries and CP violation

    International Nuclear Information System (INIS)

    The exclusive reaction /bar p/p → /bar Lambda/Λ is an interesting laboratory in which to study both spin physics and fundamental symmetries. The PS185 collaboration at LEAR has been exploiting this fact for the last few years in an ongoing program of hyperon-antihyperon production. The motivation for this study will be outlined and the experimental technique will be described. Spin physics aspects such as the measurements of the outgoing hyperon polarization and preliminary determinations of spin correlation coefficients will be presented. Fundamental symmetry checks such as lifetime differences between Λ and /bar Lambda/ (CPT) and decay properties (CP) will be discussed. A future experiment which is quite sensitive to CP violation in a hyperon-antihyperon system will be mentioned. 15 refs., 4 figs

  5. The gradient flow in $\\lambda\\phi^{4}$ theory

    CERN Document Server

    Fujikawa, Kazuo

    2016-01-01

    A gradient flow equation for $\\lambda\\phi^{4}$ theory in $D=4$ is formulated. In this scheme the gradient flow equation is written in terms of the renormalized probe variable $\\Phi(t,x)$ and renormalized parameters $m^{2}$ and $\\lambda$ in a manner analogous to the higher derivative regularization. No extra divergence is induced in the interaction of the probe variable $\\Phi(t,x)$ and the 4-dimensional dynamical variable $\\phi(x)$ which is defined in renormalized perturbation theory. The finiteness to all orders in perturbation theory is established by power counting argument in the context of $D+1$ dimensional field theory. This simple model will be useful to understand the basic smearing mechanism.

  6. Target space supergeometry of $\\eta$ and $\\lambda$-deformed strings

    CERN Document Server

    Borsato, Riccardo

    2016-01-01

    We study the integrable $\\eta$ and $\\lambda$-deformations of supercoset string sigma models, the basic example being the deformation of the $AdS_5 \\times S^5$ superstring. We prove that the kappa symmetry variations for these models are of the standard Green-Schwarz form, and we determine the target space supergeometry by computing the superspace torsion. We check that the $\\lambda$-deformation gives rise to a standard supergravity background; for the $\\eta$-model the requirement that the target space is a supergravity solution translates into a simple condition on the R-matrix which enters the definition of the deformation. We further construct all such non-abelian R-matrices of rank four which solve the homogeneous classical Yang-Baxter equation for the algebra so(2,4). We argue that the corresponding backgrounds are equivalent to sequences of non-commuting TsT-transformations, and verify this explicitly for some of the examples.

  7. Programacion funcional y lambda cálculo

    Directory of Open Access Journals (Sweden)

    Jonatan Gómez Perdomo

    2011-05-01

    Full Text Available En la primera parte de este artículo se explican algunos conceptos de los lenguajes de programación, haciendo énfasis en las caracteristicas y propiedades de los lenguajes de programación funcional. En la segunda, se realiza una introducción al lambda cálculo puro, su notación, axiomas y reglas elementales.

  8. Coalgebraic reasoning in Coq: bisimulation and lambda-coiteration scheme

    OpenAIRE

    Niqui, Milad

    2008-01-01

    In this work we present a modular theory of the coalgebras and bisimulation in the intensional type theory implemented in Coq. On top of that we build the theory of weakly final coalgebras and develop the lambda-coiteration scheme, thereby extending the class of specifications definable in Coq. We provide an instantiation of the theory for the coalgebra of streams and show how some of the productive specifications violating the guardedness condition of Coq can be formalised using our library.

  9. Standardization of a Call-By-Value Lambda-Calculus

    OpenAIRE

    Guerrieri, Giulio; Paolini, Luca; Ronchi Della Rocca, Simona

    2015-01-01

    We study an extension of Plotkin's call-by-value lambda-calculus by means of two commutation rules (sigma-reductions). Recently, it has been proved that this extended calculus provides elegant characterizations of many semantic properties, as for example solvability. We prove a standardization theorem for this calculus by generalizing Takahashi's approach of parallel reductions. The standardization property allows us to prove that our calculus is conservative with respect to the Plotkin's one...

  10. On lambda and omega measurements and acceleration of universe expansion

    CERN Document Server

    Semyonov, O G

    2004-01-01

    The data for luminisity distances to the high-redshift Ia supernovas measured by the Supernova Cosmology Project team with the relativistic correction factors for redshift and time dilation led to the sensational conclusion about acceleration of universe expansion. The effect of relativistic aberration of high-redshift sources requires an additional correcting factor for the magnitudes of SN Ia supernovas which can reduce the data to fit the universe with lambda = 0, i.e. without acceleration.

  11. Bacteriophages of Soft Rot Enterobacteriaceae-a minireview.

    Science.gov (United States)

    Czajkowski, Robert

    2016-01-01

    Soft rot Enterobacteriaceae (Pectobacterium spp. and Dickeya spp., formerly pectinolytic Erwinia spp.) are ubiquitous necrotrophic bacterial pathogens that infect a large number of different plant species worldwide, including economically important crops. Despite the fact that these bacteria have been studied for more than 50 years, little is known of their corresponding predators: bacteriophages, both lytic and lysogenic. The aim of this minireview is to critically summarize recent ecological, biological and molecular research on bacteriophages infecting Pectobacterium spp. and Dickeya spp. with the main focus on current and future perspectives in that field.

  12. Engineered enzymatically active bacteriophages and methods of uses thereof

    Energy Technology Data Exchange (ETDEWEB)

    Collins, James J (Newton, MA); Kobayashi, Hideki (Yokohama, JP); Kearn, Mads (Ottawa, CA); Araki, Michihiro (Minatoku, JP); Friedland, Ari (Boston, MA); Lu, Timothy Kuan-Ta (Palo Alto, CA)

    2012-05-22

    The present invention provides engineered bacteriophages that express at least one biofilm degrading enzyme on their surface and uses thereof for degrading bacterial biofilms. The invention also provides genetically engineered bacteriophages expressing the biofilm degrading enzymes and proteins necessary for the phage to replicate in different naturally occurring biofilm producing bacteria. The phages of the invention allow a method of biofilm degradation by the use of one or only a few administration of the phage because the system using these phages is self perpetuating, and capable of degrading biofilm even when the concentration of bacteria within the biofilm is low.

  13. Molecular and chemical engineering of bacteriophages for potential medical applications.

    Science.gov (United States)

    Hodyra, Katarzyna; Dąbrowska, Krystyna

    2015-04-01

    Recent progress in molecular engineering has contributed to the great progress of medicine. However, there are still difficult problems constituting a challenge for molecular biology and biotechnology, e.g. new generation of anticancer agents, alternative biosensors or vaccines. As a biotechnological tool, bacteriophages (phages) offer a promising alternative to traditional approaches. They can be applied as anticancer agents, novel platforms in vaccine design, or as target carriers in drug discovery. Phages also offer solutions for modern cell imaging, biosensor construction or food pathogen detection. Here we present a review of bacteriophage research as a dynamically developing field with promising prospects for further development of medicine and biotechnology.

  14. Salmonella and Campylobacter: Antimicrobial resistance and bacteriophage control in poultry.

    Science.gov (United States)

    Grant, Ar'Quette; Hashem, Fawzy; Parveen, Salina

    2016-02-01

    Salmonella and Campylobacter are major causes of foodborne related illness and are traditionally associated with consuming undercooked poultry and/or consuming products that have been cross contaminated with raw poultry. Many of the isolated Salmonella and Campylobacter that can cause disease have displayed antimicrobial resistance phenotypes. Although poultry producers have reduced on-the-farm overuse of antimicrobials, antimicrobial resistant Salmonella and Campylobacter strains still persist. One method of bio-control, that is producing promising results, is the use of lytic bacteriophages. This review will highlight the current emergence and persistence of antimicrobial resistant Salmonella and Campylobacter recovered from poultry as well as bacteriophage research interventions and limitations.

  15. Mechanism of bacteriophage conversion of lipase activity in Staphylococcus aureus.

    OpenAIRE

    Lee, C Y; Iandolo, J J

    1985-01-01

    Staphylococcus aureus PS54 harbors two temperate bacteriophages and manifests no lipase activity on egg yolk agar. Curing of one of the resident prophages (L54a) restores lipase activity. To study the mechanism of bacteriophage conversion, the prophage was cured, and the gene encoding lipase activity was cloned into pBR322 in Escherichia coli on a 2.9-kilobase DNA fragment of the chromosome. The fragment was subcloned into a shuttle vector and subsequently transformed into S. aureus and Bacil...

  16. Environmental augmentation with bacteriophage prevents colibacillosis in broiler chickens.

    Science.gov (United States)

    El-Gohary, F A; Huff, W E; Huff, G R; Rath, N C; Zhou, Z Y; Donoghue, A M

    2014-11-01

    Bacteriophages are viruses that kill bacteria. They are plentiful in nature; are safe, having no known activity to human or animal cells; and are an attractive alternative to antibiotics. The objectives of this research were to establish an experimental model of colibacillosis induced by indirect exposure to Escherichia coli and to determine if bacteriophage could protect the birds from developing colibacillosis. In study 1 there were 6 treatments with 2 replicate pens of 25 birds. The treatments were control warm brooded; control cold stressed; litter inoculated with E. coli, warm brooded; litter inoculated with E. coli, cold stressed; seeder birds (5 per pen) challenged with E. coli, warm brooded; and seeder birds (5 per pen), cold stressed. The study concluded when the birds were 3 wk of age. Body weights at 1, 2, and 3 wk of age were significantly decreased (P ≤ 0.05) by cold stress, decreased at 1 and 2 wk of age by both the litter and seeder bird treatments compared with the control treatment and by the seeder bird treatment at 3 wk of age. Study 2 consisted of 8 treatments with 2 replicate pens of 20 birds per treatment. The treatments were control, warm brooded; control, cold stressed; litter inoculated with E. coli, cold stressed; and seeder birds (5/pen) challenged with E. coli, cold stressed with and without bacteriophage treatment. In the bacteriophage treatments the bacteriophages were sprayed on the litter. The study was concluded at 3 wk of age. Body weights at 1 wk of age were significantly (P ≤ 0.05) decreased from the control treatment by the seeder bird treatment and were significantly (P ≤ 0.05) higher in all the bacteriophage treatments compared with their matched untreated treatments, except in the control cold stressed treatment. Mortality was significantly (P ≤ 0.05) decreased by bacteriophage in the litter challenged treatment. These data suggest that augmentation of the environment with bacteriophage is a practical and efficacious

  17. Topological semigroups of matrix units and countably compact Brandt $\\lambda^0$-extensions of topological semigroups

    CERN Document Server

    Gutik, Oleg; Reiter, Andriy

    2009-01-01

    We show that a topological semigroup of finite partial bijections $\\mathscr{I}_\\lambda^n$ of an infinite set with a compact subsemigroup of idempotents is absolutely $H$-closed and any countably compact topological semigroup does not contain $\\mathscr{I}_\\lambda^n$ as a subsemigroup. We give sufficient conditions onto a topological semigroup $\\mathscr{I}_\\lambda^1$ to be non-$H$-closed. Also we describe the structure of countably compact Brandt $\\lambda^0$-extensions of topological monoids and study the category of countably compact Brandt $\\lambda^0$-extensions of topological monoids with zero.

  18. Phenomenologically varying \\Lambda and a toy model for the Universe

    CERN Document Server

    Khurshudyan, M; Chubaryan, E; Farahani, H

    2014-01-01

    We consider a model of the Universe with variable G and {\\Lambda}. Subject of our interest is a phenomenological model for {\\Lambda} proposed and considered in this article first time (up to our knowledge). Modification based on an assumption that ghost dark energy exists and Universe will feel it through {\\Lambda}. In that case we would like to consider possibility that there exist some unusual connections between different components of the fluids existing in Universe. We would like to stress, that this is just an assumption and could be very far from the reality. We are interested by this model as a phenomenological and mathematical and unfortunately, we will not discuss about physical conditions and possibilities of having such modifications. To test our assumption and to observe behavior of the Universe, we will consider toy models filled by a barotropic fluid and modified Chaplyagin gas. To complete the logic of the research we will consider interaction between barotropic fluid or Chaplygin gas with gho...

  19. The decays $\\Lambda_{b,c}\\to N^*\\, l\\,\

    CERN Document Server

    Emmerich, Maximilian; Schäfer, Andreas

    2016-01-01

    We present an exploratory study of the $\\Lambda_{c,b}\\to N^*$-form factors and the semileptonic decay width within the framework of light-cone sum rules. We use two different methods and two different interpolating currents for the $\\Lambda_{c,b}$. As interpolating currents we choose an axial-vector like and a pseudoscalar like current. Our results show that the procedure of eliminating negative parity partners is not well suited for the case at hand and that the second approach using structures with highest powers of $p_+$ with an axial-vector like interpolating current gives the most reliable results. Our predictions are based on the models obtained in \\cite{Anikin:2015ita,Braun:2014wpa}. The largest uncertainty comes from the uncertainty of the twist 4 parameters $\\eta_{10},\\,\\eta_{11}$ and we take the spread between the two models in \\cite{Anikin:2015ita} as a measure for this. We get \\begin{eqnarray} \\Gamma(\\Lambda_b\\to N^*(1535) l \

  20. Measurement of the Lambda(0)(b) lifetime in the exclusive decay Lambda(0)(b) -> J/psi Lambda(0) in p(p)over-bar collisions at root s=1.96 TeV

    Energy Technology Data Exchange (ETDEWEB)

    Abazov V. M.; Abbott, B.; Acharya, B. S.; Adams, M.; Adams, T.; Alexeev, G. D.; Alkhazov, G.; Alton, A.; Alverson, G.; Aoki, M.; Askew, A.; Atkins, S.; Augsten, K.; Avila, C.; Badaud, F.; Bagby, L.; Baldin, B.; Bandurin, D. V.; Banerjee, S.; Barberis, E.; Baringer, P.; Barreto, J.; Bartlett, J. F.; Bassler, U.; Bazterra, V.; Bean, A.; Begalli, M.; Bellantoni, L.; Beri, S. B.; Bernardi, G.; Bernhard, R.; Bertram, I.; et al.

    2012-06-07

    We measure the {Lambda}{sub b}{sup 0} lifetime in the fully reconstructed decay {Lambda}{sub b}{sup 0} {yields} J/{psi}{Lambda}{sup 0} using 10.4 fb{sup -1} of p{bar p} collisions collected with the D0 detector at {radical}s = 1.96 TeV. The lifetime of the topologically similar decay channel B{sup 0} {yields} J/{psi}K{sub S}{sup 0} is also measured. We obtain {tau}({Lambda}{sub b}{sup 0}) = 1.303 {+-} 0.075(stat) {+-} 0.035(syst) ps and {tau}(B{sup 0}) = 1.508 {+-} 0.025(stat) {+-} 0.043(syst) ps. Using these measurements, we determine the lifetime ratio of {tau}({Lambda}{sub b}{sup 0})/{tau}(B{sup 0}) = 0.864 {+-} 0.052(stat) {+-} 0.033(syst).

  1. Measurement of the Lambda0(b) Lifetime in Lambda0(b) ---> J/psi Lambda0 in p anti-p Collisions at s**(1/2) = 1.96-TeV

    Energy Technology Data Exchange (ETDEWEB)

    Abulencia, A.; Adelman, J.; Affolder, T.; Akimoto, T.; Albrow, M.G.; Ambrose, D.; Amerio, S.; Amidei, D.; Anastassov, A.; Anikeev, K.; Annovi, A.; /Taiwan, Inst. Phys.

    2006-09-01

    The authors report a measurement of the {Lambda}{sub b}{sup 0} lifetime in the exclusive decay {Lambda}{sub b}{sup 0} {yields} J/{psi}{Lambda}{sup 0} in p{bar p} collisions at {radical}s = 1.96 TeV using an integrated luminosity of 1.0 fb{sup -1} of data collected by the CDF II detector at the Fermilab Tevatron. Using fully reconstructed decays, they measure {tau}({Lambda}{sub b}{sup 0}) = 1.593{sub -0.078}{sup +0.083}(stat.) {+-} 0.033(syst.) ps. This is the single most precise measurement of {tau}({Lambda}{sub b}{sup 0}) and is 3.2 {sigma} higher than the current world average.

  2. Norovirus and FRNA bacteriophage determined by RT-qPCR and infectious FRNA bacteriophage in wastewater and oysters.

    Science.gov (United States)

    Flannery, John; Keaveney, Sinéad; Rajko-Nenow, Paulina; O'Flaherty, Vincent; Doré, William

    2013-09-15

    Norovirus (NoV), the leading cause of adult non-bacterial gastroenteritis can be commonly detected in wastewater but the extent of NoV removal provided by wastewater treatment plants (WWTPs) is unclear. We monitored a newly commissioned WWTP with UV disinfection on a weekly basis over a six month period for NoV using RT-qPCR and for FRNA bacteriophage GA using both RT-qPCR (total concentration) and a plaque assay (infectious concentration). Mean concentrations of NoV GI and GII in influent wastewater were reduced by 0.25 and 0.41 log10 genome copies 100 ml(-1), respectively by the WWTP. The mean concentration of total FRNA bacteriophage GA was reduced by 0.35 log genome copies 100 ml(-1) compared to a reduction of infectious FRNA bacteriophage GA of 2.13 log PFU 100 ml(-1). A significant difference between concentrations of infectious and total FRNA bacteriophage GA was observed in treated, but not in untreated wastewaters. We conclude that RT-qPCR in isolation underestimates the reduction of infectious virus during wastewater treatment. We further compared the concentrations of infectious virus in combined sewer overflow (CSO) and UV treated effluents using FRNA bacteriophage GA. A greater percentage (98%) of infectious virus is released in CSO discharges than UV treated effluent (44%). Following a CSO discharge, concentrations of NoV GII and infectious FRNA bacteriophage GA in oysters from less than the limit of detection to 3150 genome copies 100 g(-1) and 1050 PFU 100 g(-1) respectively.

  3. On the Binding Energy and the Charge Symmetry Breaking in A<=16 Lambda-hypernuclei

    CERN Document Server

    Botta, E; Feliciello, A

    2016-01-01

    Recent achievements in hypernuclear spectroscopy, in particular the determination of the $\\Lambda$-binding energy B$_{\\Lambda}$ by high precision magnetic spectrometry, contributed to stimulate considerably the search for Charge Symmetry Breaking effects in $\\Lambda$-hypernuclei isomultiplets. We have reorganized the results from the FINUDA experiment and we have produced a list of B$_{\\Lambda}$ values for hypernuclei with A$\\leq$16 considering only the data from magnetic spectrometers with an absolute calibration of the energy scale (FINUDA at DA$\\Phi$NE and electroproduction experiments). By comparing them with the corresponding B$_{\\Lambda}$ from the emulsion experiments, we observe that there is a systematic small difference that is taken into account. A synopsis of all the results on B$_{\\Lambda}$ so far published is finally suggested. Several interesting conclusions are drawn, among which the equality within the errors of B$_{\\Lambda}$ for the A=7, 12, 16 isomultiplets, based only on recent spectrometri...

  4. Inactivation of lambda phage infectivity and lambda deoxyribonucleic acid transfection by N-methyl-isatin beta-thiosemicarbazone-copper complexes.

    Science.gov (United States)

    Levinson, W; Helling, R

    1976-01-01

    The infectivity of intact lambda phage and transfection by lambda deoxyribonucleic acid were inactivated by exposure to the copper complexes of N-methyl-isatin beta-thiosemicarbazone, thiosemicarbazide, and semicarbazide, but not methyl-isatin. No inactivation was observed when these compounds were used in the absence of copper sulfate. This confirms our previous observation that the activity of N-methyl-isatin beta-thiosemicarbazone is mediated by its thiosemicarbazone moiety and that the presence of copper is required for action. This represents the first time, to our knowledge, that semicarbazide has been found to possess antiviral activity. It is clear that these compounds act directly on deoxyribonucleic acid; whether the compounds also act on proteins has not been determined. PMID:769669

  5. Performance of microstrip gas chambers in BNL-E885: a search for LAMBDA LAMBDA-hypernuclei

    CERN Document Server

    Landry, M; Davis, C A; Faszer, W; Gan, L; Lee, L; Page, S A; Ramsay, W D; Salomon, M; Oers, W T H

    1999-01-01

    The performance of MicroStrip Gas Chambers (MSGC) in BNL Experiment 885, a search for LAMBDA LAMBDA-hypernuclei, is detailed. Chambers with an active area of 80x50 mm sup 2 were instrumented and operated as a vertex detector in the experiment. Furthermore, two distinct types of microstrip prints were utilized in these chambers. Prints manufactured with Integrated Circuit (IC) photolithographic technology have fine tolerances and thin minimum trace widths, but can suffer from a high rate of defects per print and are more costly. Prints constructed with Printed Circuit (PC) photolithographic technology have coarser tolerances but relatively few defects per print, and are extremely cost-effective. Results of bench and beam tests of both IC and PC based MSGCs are presented and their performance in BNL-E885 is discussed. E885 marks the first use of PC based MSGCs in an experiment.

  6. Novel bacteriophages containing a genome of another bacteriophage within their genomes.

    Directory of Open Access Journals (Sweden)

    Maud M Swanson

    Full Text Available A novel bacteriophage infecting Staphylococus pasteuri was isolated during a screen for phages in Antarctic soils. The phage named SpaA1 is morphologically similar to phages of the family Siphoviridae. The 42,784 bp genome of SpaA1 is a linear, double-stranded DNA molecule with 3' protruding cohesive ends. The SpaA1 genome encompasses 63 predicted protein-coding genes which cluster within three regions of the genome, each of apparently different origin, in a mosaic pattern. In two of these regions, the gene sets resemble those in prophages of Bacillus thuringiensis kurstaki str. T03a001 (genes involved in DNA replication/transcription, cell entry and exit and B. cereus AH676 (additional regulatory and recombination genes, respectively. The third region represents an almost complete genome (except for the short terminal segments of a distinct bacteriophage, MZTP02. Nearly the same gene module was identified in prophages of B. thuringiensis serovar monterrey BGSC 4AJ1 and B. cereus Rock4-2. These findings suggest that MZTP02 can be shuttled between genomes of other bacteriophages and prophages, leading to the formation of chimeric genomes. The presence of a complete phage genome in the genome of other phages apparently has not been described previously and might represent a 'fast track' route of virus evolution and horizontal gene transfer. Another phage (BceA1 nearly identical in sequence to SpaA1, and also including the almost complete MZTP02 genome within its own genome, was isolated from a bacterium of the B. cereus/B. thuringiensis group. Remarkably, both SpaA1 and BceA1 phages can infect B. cereus and B. thuringiensis, but only one of them, SpaA1, can infect S. pasteuri. This finding is best compatible with a scenario in which MZTP02 was originally contained in BceA1 infecting Bacillus spp, the common hosts for these two phages, followed by emergence of SpaA1 infecting S. pasteuri.

  7. Immobilization of Active Bacteriophages on Polyhydroxyalkanoate Surfaces.

    Science.gov (United States)

    Wang, Chanchan; Sauvageau, Dominic; Elias, Anastasia

    2016-01-20

    A rapid, efficient technique for the attachment of bacteriophages (phages) onto polyhydroxyalkanoate (PHA) surfaces has been developed and compared to three reported methods for phage immobilization. Polymer surfaces were modified to facilitate phage attachment using (1) plasma treatment alone, (2) plasma treatment followed by activation by 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride (EDC) and N-hydroxysulfosuccinimide (sulfo-NHS), (3) plasma-initiated acrylic acid grafting, or (4) plasma-initiated acrylic acid grafting with activation by EDC and sulfo-NHS. The impact of each method on the surface chemistry of PHA was investigated using contact angle analysis and X-ray photoelectron spectroscopy. Each of the four treatments was shown to result in both increased hydrophilicity and in the modification of the surface functional groups. Modified surfaces were immersed in suspensions of phage T4 for immobilization. The highest level of phage binding was observed for the surfaces modified by plasma treatment alone. The change in chemical bond states observed for surfaces that underwent plasma treatment is suspected to be the cause of the increased binding of active phages. Plasma-treated surfaces were further analyzed through phage-staining and fluorescence microscopy to assess the surface density of immobilized phages and their capacity to capture hosts. The infective capability of attached phages was confirmed by exposing the phage-immobilized surfaces to the host bacteria Escherichia coli in both plaque and infection dynamic assays. Plasma-treated surfaces with immobilized phages displayed higher infectivity than surfaces treated with other methods; in fact, the equivalent initial multiplicity of infection was 2 orders of magnitude greater than with other methods. Control samples - prepared by immersing polymer surfaces in phage suspensions (without prior plasma treatment) - did not show any bacterial growth inhibition, suggesting they did not bind

  8. Effects of bacteriophage traits on plaque formation

    Directory of Open Access Journals (Sweden)

    Kannoly Sherin

    2011-08-01

    Full Text Available Abstract Background The appearance of plaques on a bacterial lawn is one of the enduring imageries in modern day biology. The seeming simplicity of a plaque has invited many hypotheses and models in trying to describe and explain the details of its formation. However, until now, there has been no systematic experimental exploration on how different bacteriophage (phage traits may influence the formation of a plaque. In this study, we constructed a series of isogenic λ phages that differ in their adsorption rate, lysis timing, or morphology so that we can determine the effects if these changes on three plaque properties: size, progeny productivity, and phage concentration within plaques. Results We found that the adsorption rate has a diminishing, but negative impact on all three plaque measurements. Interestingly, there exists a concave relationship between the lysis time and plaque size, resulting in an apparent optimal lysis time that maximizes the plaque size. Although suggestive in appearance, we did not detect a significant effect of lysis time on plaque productivity. Nonetheless, the combined effects of plaque size and productivity resulted in an apparent convex relationship between the lysis time and phage concentration within plaques. Lastly, we found that virion morphology also affected plaque size. We compared our results to the available models on plaque size and productivity. For the models in their current forms, a few of them can capture the qualitative aspects of our results, but not consistently in both plaque properties. Conclusions By using a collection of isogenic phage strains, we were able to investigate the effects of individual phage traits on plaque size, plaque productivity, and average phage concentration in a plaque while holding all other traits constant. The controlled nature of our study allowed us to test several model predictions on plaque size and plaque productivity. It seems that a more realistic theoretical

  9. Utilizing Synthetic Spectra to Refine Lambda Boo Stars' UV Classification Criteria

    Science.gov (United States)

    Cheng, Kwang-Ping; Neff, James E.; Johnson, Dustin; Tarbell, Erik; Romo, Christopher; Steele, Patricia; Gray, Richard O.; Corbally, Christopher J.

    2016-01-01

    Lambda Boo-type stars are a group of late B to early F-type Population I dwarfs that show deficiencies of iron-peak elements (up to 2 dex), but their C, N, O, and S abundances are near solar. This stellar class has recently regained the spotlight because of the directly-imaged planets around a confirmed Lambda Boo star, HR 8799, and a suggested Lambda Boo star Beta Pictoris. The discovery of a giant asteroid belt around Vega, another possible Lambda Boo star, also suggests hidden planets. This possible link between Lambda Boo stars and planet-bearing stars motivates us to study Lambda Boo stars systematically. Since the peculiar nature of the prototype Lambda Bootis was first noticed in 1943, Lambda Boo candidates published in the literature have been selected using widely different criteria. The Lambda Boo label has been applied to almost any peculiar A-type stars that do not fit elsewhere. In order to determine the origin of Lambda Boo stars' unique abundance pattern and to better discriminate between theories explaining the Lambda Boo phenomenon, a consistent working definition of Lambda Boo stars is needed. We have re-evaluated all published Lambda Boo candidates and their available ultraviolet and visible spectra. Using observed and synthetic spectra, we explored the classification of Lambda Boo stars and developed quantitative criteria that discriminate metal-poor stars from bona fide Lambda Boo stars. With model spectra, we demonstrated that the (C I 1657 Angstrom)/ (Al II 1671 Angstrom) line ratio is the best single criterion to distinguish between Lambda Boo stars and metal weak stars, and that one cannot use a single C I/Al II cut-off value as a Lambda Boo classification criterion. The C I/Al II cut-off value is a function of a star's effective temperature and metallicity. Using these stricter Lambda Boo classification criteria, we concluded that neither Beta Pictoris nor Vega should be classified as Lambda Boo stars.

  10. STUDIES ON THE BACTERIOPHAGE OF D'HERELLE : VII. ON THE PARTICULATE NATURE OF BACTERIOPHAGE.

    Science.gov (United States)

    Bronfenbrenner, J

    1927-04-30

    When filtrates of lysed cultures (bacteriophage) are subjected to prolonged dialysis under osmotic pressure against water, the presence of the lytic agent can be detected outside the membrane only during the first few days. The residue remaining inside the membrane contains the bulk of the original lytic agent, and yet it is no longer capable of diffusing into the outer solution. The interruption of diffusion is shown not to be due to any alteration in the permeability of the membrane. Moreover, the residue fails to diffuse through a fresh membrane of similar permeability, while the dialyzed portion of the phage passes quantitatively through a new membrane. When ultrafiltration under pressure was substituted for dialysis, the residue on the filter could be washed repeatedly with water without giving off into the filtrate any more active agent. However, if broth was substituted for water, a renewed diffusion of the active agent resulted. These results are interpreted as indicating that the colloidal particles present in the lytic filtrates (and apparently endowed with properties of bacteriophage) do not represent autonomous units of the active agent, but merely serve as a vehicle on which the agent is adsorbed. The vary in size within limits wide enough to permit fractionation by means of ultrafiltration. When the coarser particles retained by the ultrafilter are washed with broth, some of the active agent is detached from its coarse vehicle particles. The agent, now more highly dispersed, is capable of passing the filter which held it back previously. Preparation of a simple ultrafilter used in these experiments is given in detail.

  11. Polarization effects in the cascade decay Lambda_b -> Lambda(-> p pi-) + J/psi(-> l+ l-) in the covariant confined quark model

    CERN Document Server

    Gutsche, Thomas; Korner, Jurgen G; Lyubovitskij, Valery E; Santorelli, Pietro

    2013-01-01

    We calculate the invariant and helicity amplitudes for the nonleptonic decay Lambda_b -> Lambda + J/psi, psi(2S) in the covariant confined quark model. We discuss joint angular decay distributions in the cascade decay Lambda_b -> Lambda(-> p pi-) + J/psi, psi(2S) (-> l+ l-) and calculate some of the asymmetry parameters that characterize the joint angular decay distribution. We confirm expectations from the naive quark model that the transitions into the lambda_Lambda=1/2 helicity states of the daughter baryon Lambda are strongly suppressed leading to a near maximal negative polarization of the Lambda. For the same reason the azimuthal correlation between the two decay planes spanned by (p pi-) and (l+ l-) is negligibly small. We provide form factor results for the whole accessible q2-range. Our results are close to lattice results at minimum recoil and light-cone sum rule results at maximum recoil. A new feature of our analysis is that we include lepton mass effects in the calculation which allows us to also...

  12. More Is Better: Selecting for Broad Host Range Bacteriophages.

    Science.gov (United States)

    Ross, Alexa; Ward, Samantha; Hyman, Paul

    2016-01-01

    Bacteriophages are viruses that infect bacteria. In this perspective, we discuss several aspects of a characteristic feature of bacteriophages, their host range. Each phage has its own particular host range, the range of bacteria that it can infect. While some phages can only infect one or a few bacterial strains, other phages can infect many species or even bacteria from different genera. Different methods for determining host range may give different results, reflecting the multiple mechanisms bacteria have to resist phage infection and reflecting the different steps of infection each method depends on. This makes defining host range difficult. Another difficulty in describing host range arises from the inconsistent use of the words "narrow" and especially "broad" when describing the breadth of the host range. Nearly all bacteriophages have been isolated using a single host strain of bacteria. While this procedure is fairly standard, it may more likely produce narrow rather than broad host range phage. Our results and those of others suggest that using multiple host strains during isolation can more reliably produce broader host range phages. This challenges the common belief that most bacteriophages have a narrow host range. We highlight the implications of this for several areas that are affected by host range including horizontal gene transfer and phage therapy. PMID:27660623

  13. Bacteriophage for prophylaxis and therapy in cattle, poultry, and pigs.

    Science.gov (United States)

    The successful use of virulent (lytic) bacteriophages (phages) in preventing and treating neonatal enterotoxigenic Escherichia coli infections in calves, lambs and pigs has prompted investigation of other applications phage therapy in food animals. While results have been very variable, some indica...

  14. Genome Sequences of Gordonia terrae Bacteriophages Phinally and Vivi2.

    Science.gov (United States)

    Pope, Welkin H; Anderson, Kaitlyn C; Arora, Charu; Bortz, Michael E; Burnet, George; Conover, David H; D'Incau, Gina M; Ghobrial, Jonathan A; Jonas, Audrey L; Migdal, Emily J; Rote, Nicole L; German, Brian A; McDonnell, Jill E; Mezghani, Nadia; Schafer, Claire E; Thompson, Paige K; Ulbrich, Megan C; Yu, Victor J; Furbee, Emily C; Grubb, Sarah R; Warner, Marcie H; Montgomery, Matthew T; Garlena, Rebecca A; Russell, Daniel A; Jacobs-Sera, Deborah; Hatfull, Graham F

    2016-08-18

    Bacteriophages Phinally and Vivi2 were isolated from soil from Pittsburgh, Pennsylvania, USA, using host Gordonia terrae 3612. The Phinally and Vivi2 genomes are 59,265 bp and 59,337 bp, respectively, and share sequence similarity with each other and with GTE6. Fewer than 25% of the 87 to 89 putative genes have predictable functions.

  15. Bacteriophages Limit the Existence Conditions for Conjugative Plasmids

    Science.gov (United States)

    Wood, A. Jamie; Dytham, Calvin; Pitchford, Jonathan W.; Truman, Julie; Spiers, Andrew; Paterson, Steve; Brockhurst, Michael A.

    2015-01-01

    ABSTRACT Bacteriophages are a major cause of bacterial mortality and impose strong selection on natural bacterial populations, yet their effects on the dynamics of conjugative plasmids have rarely been tested. We combined experimental evolution, mathematical modeling, and individual-based simulations to explain how the ecological and population genetics effects of bacteriophages upon bacteria interact to determine the dynamics of conjugative plasmids and their persistence. The ecological effects of bacteriophages on bacteria are predicted to limit the existence conditions for conjugative plasmids, preventing persistence under weak selection for plasmid accessory traits. Experiments showed that phages drove faster extinction of plasmids in environments where the plasmid conferred no benefit, but they also revealed more complex effects of phages on plasmid dynamics under these conditions, specifically, the temporary maintenance of plasmids at fixation followed by rapid loss. We hypothesized that the population genetic effects of bacteriophages, specifically, selection for phage resistance mutations, may have caused this. Further mathematical modeling and individual-based simulations supported our hypothesis, showing that conjugative plasmids may hitchhike with phage resistance mutations in the bacterial chromosome. PMID:26037122

  16. More Is Better: Selecting for Broad Host Range Bacteriophages.

    Science.gov (United States)

    Ross, Alexa; Ward, Samantha; Hyman, Paul

    2016-01-01

    Bacteriophages are viruses that infect bacteria. In this perspective, we discuss several aspects of a characteristic feature of bacteriophages, their host range. Each phage has its own particular host range, the range of bacteria that it can infect. While some phages can only infect one or a few bacterial strains, other phages can infect many species or even bacteria from different genera. Different methods for determining host range may give different results, reflecting the multiple mechanisms bacteria have to resist phage infection and reflecting the different steps of infection each method depends on. This makes defining host range difficult. Another difficulty in describing host range arises from the inconsistent use of the words "narrow" and especially "broad" when describing the breadth of the host range. Nearly all bacteriophages have been isolated using a single host strain of bacteria. While this procedure is fairly standard, it may more likely produce narrow rather than broad host range phage. Our results and those of others suggest that using multiple host strains during isolation can more reliably produce broader host range phages. This challenges the common belief that most bacteriophages have a narrow host range. We highlight the implications of this for several areas that are affected by host range including horizontal gene transfer and phage therapy.

  17. Complete Genome Sequence of Bacillus thuringiensis Bacteriophage Smudge.

    Science.gov (United States)

    Cornell, Jessica L; Breslin, Eileen; Schuhmacher, Zachary; Himelright, Madison; Berluti, Cassandra; Boyd, Charles; Carson, Rachel; Del Gallo, Elle; Giessler, Caris; Gilliam, Benjamin; Heatherly, Catherine; Nevin, Julius; Nguyen, Bryan; Nguyen, Justin; Parada, Jocelyn; Sutterfield, Blake; Tukruni, Muruj; Temple, Louise

    2016-01-01

    Smudge, a bacteriophage enriched from soil using Bacillus thuringiensis DSM-350 as the host, had its complete genome sequenced. Smudge is a myovirus with a genome consisting of 292 genes and was identified as belonging to the C1 cluster of Bacillus phages. PMID:27540049

  18. Complete Genome Sequence of Bacillus thuringiensis Bacteriophage Smudge

    Science.gov (United States)

    Cornell, Jessica L.; Breslin, Eileen; Schuhmacher, Zachary; Himelright, Madison; Berluti, Cassandra; Boyd, Charles; Carson, Rachel; Del Gallo, Elle; Giessler, Caris; Gilliam, Benjamin; Heatherly, Catherine; Nevin, Julius; Nguyen, Bryan; Nguyen, Justin; Parada, Jocelyn; Sutterfield, Blake; Tukruni, Muruj

    2016-01-01

    Smudge, a bacteriophage enriched from soil using Bacillus thuringiensis DSM-350 as the host, had its complete genome sequenced. Smudge is a myovirus with a genome consisting of 292 genes and was identified as belonging to the C1 cluster of Bacillus phages. PMID:27540049

  19. Complete Genome Sequence of Bacillus thuringiensis Bacteriophage Smudge.

    Science.gov (United States)

    Cornell, Jessica L; Breslin, Eileen; Schuhmacher, Zachary; Himelright, Madison; Berluti, Cassandra; Boyd, Charles; Carson, Rachel; Del Gallo, Elle; Giessler, Caris; Gilliam, Benjamin; Heatherly, Catherine; Nevin, Julius; Nguyen, Bryan; Nguyen, Justin; Parada, Jocelyn; Sutterfield, Blake; Tukruni, Muruj; Temple, Louise

    2016-08-18

    Smudge, a bacteriophage enriched from soil using Bacillus thuringiensis DSM-350 as the host, had its complete genome sequenced. Smudge is a myovirus with a genome consisting of 292 genes and was identified as belonging to the C1 cluster of Bacillus phages.

  20. Role of osmotic and hydrostatic pressures in bacteriophage genome ejection

    NARCIS (Netherlands)

    Lemay, S.G.; Panja, D.; Molineux, I.J.

    2013-01-01

    A critical step in the bacteriophage life cycle is genome ejection into host bacteria. The ejection process for double-stranded DNA phages has been studied thoroughly in vitro, where after triggering with the cellular receptor the genome ejects into a buffer. The experimental data have been interpre

  1. More Is Better: Selecting for Broad Host Range Bacteriophages

    Science.gov (United States)

    Ross, Alexa; Ward, Samantha; Hyman, Paul

    2016-01-01

    Bacteriophages are viruses that infect bacteria. In this perspective, we discuss several aspects of a characteristic feature of bacteriophages, their host range. Each phage has its own particular host range, the range of bacteria that it can infect. While some phages can only infect one or a few bacterial strains, other phages can infect many species or even bacteria from different genera. Different methods for determining host range may give different results, reflecting the multiple mechanisms bacteria have to resist phage infection and reflecting the different steps of infection each method depends on. This makes defining host range difficult. Another difficulty in describing host range arises from the inconsistent use of the words “narrow” and especially “broad” when describing the breadth of the host range. Nearly all bacteriophages have been isolated using a single host strain of bacteria. While this procedure is fairly standard, it may more likely produce narrow rather than broad host range phage. Our results and those of others suggest that using multiple host strains during isolation can more reliably produce broader host range phages. This challenges the common belief that most bacteriophages have a narrow host range. We highlight the implications of this for several areas that are affected by host range including horizontal gene transfer and phage therapy. PMID:27660623

  2. Multiple roles of genome-attached bacteriophage terminal proteins

    Energy Technology Data Exchange (ETDEWEB)

    Redrejo-Rodríguez, Modesto; Salas, Margarita, E-mail: msalas@cbm.csic.es

    2014-11-15

    Protein-primed replication constitutes a generalized mechanism to initiate DNA or RNA synthesis in linear genomes, including viruses, gram-positive bacteria, linear plasmids and mobile elements. By this mechanism a specific amino acid primes replication and becomes covalently linked to the genome ends. Despite the fact that TPs lack sequence homology, they share a similar structural arrangement, with the priming residue in the C-terminal half of the protein and an accumulation of positively charged residues at the N-terminal end. In addition, various bacteriophage TPs have been shown to have DNA-binding capacity that targets TPs and their attached genomes to the host nucleoid. Furthermore, a number of bacteriophage TPs from different viral families and with diverse hosts also contain putative nuclear localization signals and localize in the eukaryotic nucleus, which could lead to the transport of the attached DNA. This suggests a possible role of bacteriophage TPs in prokaryote-to-eukaryote horizontal gene transfer. - Highlights: • Protein-primed genome replication constitutes a strategy to initiate DNA or RNA synthesis in linear genomes. • Bacteriophage terminal proteins (TPs) are covalently attached to viral genomes by their primary function priming DNA replication. • TPs are also DNA-binding proteins and target phage genomes to the host nucleoid. • TPs can also localize in the eukaryotic nucleus and may have a role in phage-mediated interkingdom gene transfer.

  3. Effect of gamma irradiation on bacteriophages used as viral indicators.

    Science.gov (United States)

    Jebri, Sihem; Hmaied, Fatma; Jofre, Juan; MariemYahya; Mendez, Javier; Barkallah, Insaf; Hamdi, Moktar

    2013-07-01

    This study aimed to examine the susceptibility of indicator bacteriophages towards γ-radiation to evaluate their appropriateness as viral indicators for water quality control. The effects of γ-radiation on naturally occurring somatic coliphages, F-specific coliphages and Escherichia coli were examined in raw sewage and sewage sludge. As well, the effects of radiation on bacteriophages ΦX174 and MS2, and E. coli all grown in the laboratory and seeded in distilled water, autoclaved raw sewage and a 1% peptone solution were evaluated. The inactivation of E. coli was fairly similar in all matrices. In contrast, inactivation of bacteriophages was significantly greater in distilled water than in the other matrices. These results showed the great influence of the matrix characteristics on virus inactivation. Somatic coliphages in raw sewage and sewage sludge and ΦX174 in autoclaved sewage were inactivated similarly and were far more resistant than F-specific coliphages, MS2 and E. coli. As well, F-specific RNA bacteriophages in raw sewage and sewage sludge and MS2 in autoclaved sewage were inactivated similarly and were more resistant than E. coli. In contrast, MS2 was more susceptible to γ-radiation than E. coli in distilled water. Our results showed that ΦX174 is a suitable indicator for estimating virus inactivation by γ-irradiation and corroborate the use of somatic coliphages to survey the viral quality of treated water and sludges.

  4. Multiple roles of genome-attached bacteriophage terminal proteins

    International Nuclear Information System (INIS)

    Protein-primed replication constitutes a generalized mechanism to initiate DNA or RNA synthesis in linear genomes, including viruses, gram-positive bacteria, linear plasmids and mobile elements. By this mechanism a specific amino acid primes replication and becomes covalently linked to the genome ends. Despite the fact that TPs lack sequence homology, they share a similar structural arrangement, with the priming residue in the C-terminal half of the protein and an accumulation of positively charged residues at the N-terminal end. In addition, various bacteriophage TPs have been shown to have DNA-binding capacity that targets TPs and their attached genomes to the host nucleoid. Furthermore, a number of bacteriophage TPs from different viral families and with diverse hosts also contain putative nuclear localization signals and localize in the eukaryotic nucleus, which could lead to the transport of the attached DNA. This suggests a possible role of bacteriophage TPs in prokaryote-to-eukaryote horizontal gene transfer. - Highlights: • Protein-primed genome replication constitutes a strategy to initiate DNA or RNA synthesis in linear genomes. • Bacteriophage terminal proteins (TPs) are covalently attached to viral genomes by their primary function priming DNA replication. • TPs are also DNA-binding proteins and target phage genomes to the host nucleoid. • TPs can also localize in the eukaryotic nucleus and may have a role in phage-mediated interkingdom gene transfer

  5. Repair of 8-methoxypsoralen monoadducts and diadducts in bacteriophages and bacteria

    Energy Technology Data Exchange (ETDEWEB)

    Belogurov, A.A.; Zuev, A.V.; Zavil' gel' skii, G.B.

    1976-01-01

    The combined action of 8-methoxypsoralen (8-MOP) and light with lambda greater than 310 nm on bacteriophages and bacteria results in the formation of the following two types of photo-products in the DNA: monoadducts, in which 8-MOP is covalently bound to a pyrimidine base, and diadducts or cross links, in which 8-MOP is covalently bound to two pyrimidines from complementary strands. The method of repeated irradiation has been proposed for analyzing the degree of lethality of the photoproducts in DNA. According to this method, the preparation is freed of free 8-MOP molecules after the first irradiation and then irradiated for a second time. In this case the monoadducts are converted into cross linkages between the strands. Approximately 3-10(-9) cross links/Dalton-min form in Escherichia coli DNA during the first irradiation. The rate of the formation of cross links drops by a factor of about 2 during the repeated irradiation. It has been shown that the 8-MOP monoadducts are repaired by the uvr system just as efficiently as are lethal photoproducts of the cyclobutane pyrimidine dimer type. Lethal cross linkages in bacteria and phages are repaired by the joint action of the uvr, recA, and lex systems. A scheme has been proposed for the repair of cross linkages in one genome by these systems. The photoreactivating enzyme is inactive on DNA subjected to the combined action of 8-MOP and light. The kinetics of the repair of monadducts in bacteria and phages with various defects in the repair systems have been studied. It has been shown that the products of genes recA and lex take part in the repair process according to an excision-resynthesis method. The use of the method of repeated irradiation with 8-MOP as an express method for detecting repair systems of the uvr type in cells has been proposed.

  6. Characterization of some pneumococcal bacteriophages. [Ultraviolet radiation

    Energy Technology Data Exchange (ETDEWEB)

    Porter, R.D.; Guild, W.R.

    1976-08-01

    The growth of pneumococcal phages at high cell and phage densities is enhanced strongly by the substitution of potassium for sodium in the medium. Initial titers of 2 x 10/sup 10/ to 4 x 10/sup 10/ PFU/ml are readily obtained, and concentrated stocks are stable in a storage buffer described here. The mechanism of the cation effect is obscure. Phages ..omega..3 and ..omega..8 each have linear double-stranded DNA of 33 x 10/sup 6/ daltons per particle, with an apparent guanine plus cytosine content of 47 to 49 mol percent, as determined by buoyancy and melting temperature, but with an unusual absorbance spectrum. Efficiency of plating is high if sufficient time is allowed for a relatively slow adsorption, which differs several-fold in rate between the two phages. Morphologically, these and other pneumococcal phages are similar to coliphage lambda but with a longer tail and tail fiber. Upon UV inactivation, ..omega..3 and ..omega..8 have D/sub 37/ values of 33 and 55 J/m/sup 2/, respectively, and each shows multiplicity reactivation. A total of 13 ts mutants have been isolated from the two phages, representing only two complementation groups; complementation and recombination occur between ..omega..3 and ..omega..8 mutants. Both phages provoke high-titer antisera with extensive cross-reactivity against a number of newly isolated pneumococcal phages.

  7. Utilizing Synthetic UV Spectra to Explore the Physical Basis for the Classification of Lambda Boötis Stars

    Science.gov (United States)

    Cheng, Kwang-Ping; Neff, James E.; Johnson, Dustin M.; Tarbell, Erik S.; Romo, Christopher A.; Prabhaker, Arvind; Steele, Patricia A.; Gray, Richard O.; Corbally, Christopher J.

    2016-04-01

    Lambda Boo-type stars are a group of late B to early F-type Population I dwarfs that show mild to extreme deficiencies of iron-peak elements (up to 2 dex), but their C, N, O, and S abundances are near solar. This intriguing stellar class has recently regained the spotlight because of the directly imaged planets around a confirmed Lambda Boo star, HR 8799, and a suggested Lambda Boo star, Beta Pictoris. The discovery of a giant asteroid belt around Vega, another possible Lambda Boo star, also suggests hidden planets. The possible link between Lambda Boo stars and planet-bearing stars motivates us to study Lambda Boo stars systematically. Since the peculiar nature of the prototype Lambda Boötis was first noticed in 1943, Lambda Boo candidates published in the literature have been selected using widely different criteria. In order to determine the origin of Lambda Boo stars’ unique abundance pattern and to better discriminate between theories explaining the Lambda Boo phenomenon, a consistent working definition of Lambda Boo stars is needed. We have re-evaluated all published Lambda Boo candidates and their available ultraviolet and visible spectra. In this paper, using observed and synthetic spectra, we explore the physical basis for the classification of Lambda Boo stars, and develop quantitative criteria that discriminate metal-poor stars from bona fide Lambda Boo stars. Based on these stricter Lambda Boo classification criteria, we conclude that neither Beta Pictoris nor Vega should be classified as Lambda Boo stars.

  8. UTILIZING SYNTHETIC UV SPECTRA TO EXPLORE THE PHYSICAL BASIS FOR THE CLASSIFICATION OF LAMBDA BOÖTIS STARS

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, Kwang-Ping; Johnson, Dustin M.; Tarbell, Erik S.; Romo, Christopher A.; Prabhaker, Arvind [Cal. State Univ., Fullerton, Fullerton, CA (United States); Neff, James E.; Steele, Patricia A. [College of Charleston, Charleston, SC (United States); Gray, Richard O. [Appalachian State Univ., Boone, NC (United States); Corbally, Christopher J. [Vatican Observatory, Tucson, AZ (United States)

    2016-04-15

    Lambda Boo-type stars are a group of late B to early F-type Population I dwarfs that show mild to extreme deficiencies of iron-peak elements (up to 2 dex), but their C, N, O, and S abundances are near solar. This intriguing stellar class has recently regained the spotlight because of the directly imaged planets around a confirmed Lambda Boo star, HR 8799, and a suggested Lambda Boo star, Beta Pictoris. The discovery of a giant asteroid belt around Vega, another possible Lambda Boo star, also suggests hidden planets. The possible link between Lambda Boo stars and planet-bearing stars motivates us to study Lambda Boo stars systematically. Since the peculiar nature of the prototype Lambda Boötis was first noticed in 1943, Lambda Boo candidates published in the literature have been selected using widely different criteria. In order to determine the origin of Lambda Boo stars’ unique abundance pattern and to better discriminate between theories explaining the Lambda Boo phenomenon, a consistent working definition of Lambda Boo stars is needed. We have re-evaluated all published Lambda Boo candidates and their available ultraviolet and visible spectra. In this paper, using observed and synthetic spectra, we explore the physical basis for the classification of Lambda Boo stars, and develop quantitative criteria that discriminate metal-poor stars from bona fide Lambda Boo stars. Based on these stricter Lambda Boo classification criteria, we conclude that neither Beta Pictoris nor Vega should be classified as Lambda Boo stars.

  9. Further evidence for pomeron-quark interactions: Observation of large. Lambda. sup 0 polarization in pp yields (. Lambda. sup 0 K sup + )p

    Energy Technology Data Exchange (ETDEWEB)

    Henkes, T. (Max-Planck Inst. fuer Kernphysik, Heidelberg (Germany)); Alitti, J.; Cheze, J.B.; Povh, B.; Zsembery, J. (Centre d' Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette (France)); Bonino, R.; Erhan, S.; Medinnis, M.; Schlein, P.E.; Sherwood, P.; Zweizig, J.G. (Univ. California, Los Angeles, CA (United States)); Smith, A.M. (CERN, Geneva (Switzerland)); R608 Collaboration

    1992-06-04

    We report an analysis of the diffractive reaction pp{yields}({Lambda}{sup 0}K{sup +})p, measured at r{radical}s=63 GeV in an open geometry forward spectrometer experiment at the CERN Intersecting Storage Rings. In the rest frame of the ({Lambda}{sup 0}K{sup +}) system, which has nearly the beam momentum of 31.4 GeV, the {Lambda}{sup 0} is observed to be sharply peaked forward, similar to earlier observations in the reaction pp{yields}({Lambda}{sup 0}{phi}{sup 0}K{sup +})p, which were interpreted as the first direct evidence for pomeron-quark interactions. A smaller backward peak is also observed which may be evidence for pomeron-diquark interactions. The polarization of the {Lambda}{sup 0} increases to more than 60% when the diffractive mass reaches {approx equal}2.8 GeV. (orig.).

  10. Production of $\\Lambda\\Lambda$ and $\\bar{\\Lambda \\text{n}}$ in central Pb+Pb collisions at $\\sqrt{s_{NN}}$=2.76 TeV within the covariant coalescence model

    CERN Document Server

    Sun, Kai-Jia

    2016-01-01

    We study the production of $\\Lambda\\Lambda$ and $\\bar{\\Lambda \\text{n}}$ exotic states in central Pb+Pb collisions at $\\sqrt{s_{NN}}=2.76$ TeV via both hadron and quark coalescence within the covariant coalescence model with a blast-wave-like parametrization for the phase-space configurations of constituent particles at freezeout. In the hadron coalescence, the two states are considered as molecular states while they are considered as six-quark states in the quark coalescence. For $\\bar{\\Lambda \\text{n}}$, we find that the yields of both molecular and six-quark states are much larger than the experimental upper-limits. For $\\Lambda\\Lambda$, while the molecule-state yield is much larger than the experimental upper-limits, the six-quark-state yield could be lower than the upper-limits. The higher molecule-state yields are mainly due to the large contribution of strong resonance decays into nucleons and $\\Lambda$ which can significantly enhance the molecule-state yields via hadron coalescence. Our results sugges...

  11. Study of the kinematic dependences of $\\Lambda_b^0$ production in $pp$ collisions and a measurement of the $\\Lambda_b^0 \\rightarrow \\Lambda_c^+ \\pi^-$ branching fraction

    CERN Document Server

    Aaij, Roel; Adinolfi, Marco; Affolder, Anthony; Ajaltouni, Ziad; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; An, Liupan; Anderlini, Lucio; Anderson, Jonathan; Andreassen, Rolf; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Aquines Gutierrez, Osvaldo; Archilli, Flavio; Artamonov, Alexander; Artuso, Marina; Aslanides, Elie; Auriemma, Giulio; Baalouch, Marouen; Bachmann, Sebastian; Back, John; Badalov, Alexey; Balagura, Vladislav; Baldini, Wander; Barlow, Roger; Barschel, Colin; Barsuk, Sergey; Barter, William; Batozskaya, Varvara; Bauer, Thomas; Bay, Aurelio; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Belogurov, Sergey; Belous, Konstantin; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Benton, Jack; Berezhnoy, Alexander; Bernet, Roland; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bien, Alexander; Bifani, Simone; Bird, Thomas; Bizzeti, Andrea; Bjørnstad, Pål Marius; Blake, Thomas; Blanc, Frédéric; Blouw, Johan; Blusk, Steven; Bocci, Valerio; Bondar, Alexander; Bondar, Nikolay; Bonivento, Walter; Borghi, Silvia; Borgia, Alessandra; Borsato, Martino; Bowcock, Themistocles; Bowen, Espen Eie; Bozzi, Concezio; Brambach, Tobias; van den Brand, Johannes; Bressieux, Joël; Brett, David; Britsch, Markward; Britton, Thomas; Brook, Nicholas; Brown, Henry; Bursche, Albert; Busetto, Giovanni; Buytaert, Jan; Cadeddu, Sandro; Calabrese, Roberto; Callot, Olivier; Calvi, Marta; Calvo Gomez, Miriam; Camboni, Alessandro; Campana, Pierluigi; Campora Perez, Daniel; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carranza-Mejia, Hector; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casse, Gianluigi; Cassina, Lorenzo; Castillo Garcia, Lucia; Cattaneo, Marco; Cauet, Christophe; Cenci, Riccardo; Charles, Matthew; Charpentier, Philippe; Cheung, Shu-Faye; Chiapolini, Nicola; Chrzaszcz, Marcin; Ciba, Krzystof; Cid Vidal, Xabier; Ciezarek, Gregory; Clarke, Peter; Clemencic, Marco; Cliff, Harry; Closier, Joel; Coca, Cornelia; Coco, Victor; Cogan, Julien; Cogneras, Eric; Collins, Paula; Comerma-Montells, Albert; Contu, Andrea; Cook, Andrew; Coombes, Matthew; Coquereau, Samuel; Corti, Gloria; Corvo, Marco; Counts, Ian; Couturier, Benjamin; Cowan, Greig; Craik, Daniel Charles; Cruz Torres, Melissa Maria; Cunliffe, Samuel; Currie, Robert; D'Ambrosio, Carmelo; Dalseno, Jeremy; David, Pascal; David, Pieter; Davis, Adam; De Bruyn, Kristof; De Capua, Stefano; De Cian, Michel; De Miranda, Jussara; De Paula, Leandro; De Silva, Weeraddana; De Simone, Patrizia; Decamp, Daniel; Deckenhoff, Mirko; Del Buono, Luigi; Déléage, Nicolas; Derkach, Denis; Deschamps, Olivier; Dettori, Francesco; Di Canto, Angelo; Dijkstra, Hans; Donleavy, Stephanie; Dordei, Francesca; Dorigo, Mirco; Dosil Suárez, Alvaro; Dossett, David; Dovbnya, Anatoliy; Dupertuis, Frederic; Durante, Paolo; Dzhelyadin, Rustem; Dziurda, Agnieszka; Dzyuba, Alexey; Easo, Sajan; Egede, Ulrik; Egorychev, Victor; Eidelman, Semen; Eisenhardt, Stephan; Eitschberger, Ulrich; Ekelhof, Robert; Eklund, Lars; El Rifai, Ibrahim; Elsasser, Christian; Esen, Sevda; Evans, Timothy; Falabella, Antonio; Färber, Christian; Farinelli, Chiara; Farry, Stephen; Ferguson, Dianne; Fernandez Albor, Victor; Ferreira Rodrigues, Fernando; Ferro-Luzzi, Massimiliano; Filippov, Sergey; Fiore, Marco; Fiorini, Massimiliano; Firlej, Miroslaw; Fitzpatrick, Conor; Fiutowski, Tomasz; Fontana, Marianna; Fontanelli, Flavio; Forty, Roger; Francisco, Oscar; Frank, Markus; Frei, Christoph; Frosini, Maddalena; Fu, Jinlin; Furfaro, Emiliano; Gallas Torreira, Abraham; Galli, Domenico; Gambetta, Silvia; Gandelman, Miriam; Gandini, Paolo; Gao, Yuanning; Garofoli, Justin; Garra Tico, Jordi; Garrido, Lluis; Gaspar, Clara; Gauld, Rhorry; Gavardi, Laura; Gersabeck, Evelina; Gersabeck, Marco; Gershon, Timothy; Ghez, Philippe; Gianelle, Alessio; Giani', Sebastiana; Gibson, Valerie; Giubega, Lavinia-Helena; Gligorov, Vladimir; Göbel, Carla; Golubkov, Dmitry; Golutvin, Andrey; Gomes, Alvaro; Gordon, Hamish; Gotti, Claudio; Grabalosa Gándara, Marc; Graciani Diaz, Ricardo; Granado Cardoso, Luis Alberto; Graugés, Eugeni; Graziani, Giacomo; Grecu, Alexandru; Greening, Edward; Gregson, Sam; Griffith, Peter; Grillo, Lucia; Grünberg, Oliver; Gui, Bin; Gushchin, Evgeny; Guz, Yury; Gys, Thierry; Hadjivasiliou, Christos; Haefeli, Guido; Haen, Christophe; Haines, Susan; Hall, Samuel; Hamilton, Brian; Hampson, Thomas; Han, Xiaoxue; Hansmann-Menzemer, Stephanie; Harnew, Neville; Harnew, Samuel; Harrison, Jonathan; Hartmann, Thomas; He, Jibo; Head, Timothy; Heijne, Veerle; Hennessy, Karol; Henrard, Pierre; Henry, Louis; Hernando Morata, Jose Angel; van Herwijnen, Eric; Heß, Miriam; Hicheur, Adlène; Hill, Donal; Hoballah, Mostafa; Hombach, Christoph; Hulsbergen, Wouter; Hunt, Philip; Hussain, Nazim; Hutchcroft, David; Hynds, Daniel; Idzik, Marek; Ilten, Philip; Jacobsson, Richard; Jaeger, Andreas; Jalocha, Pawel; Jans, Eddy; Jaton, Pierre; Jawahery, Abolhassan; Jezabek, Marek; Jing, Fanfan; John, Malcolm; Johnson, Daniel; Jones, Christopher; Joram, Christian; Jost, Beat; Jurik, Nathan; Kaballo, Michael; Kandybei, Sergii; Kanso, Walaa; Karacson, Matthias; Karbach, Moritz; Kelsey, Matthew; Kenyon, Ian; Ketel, Tjeerd; Khanji, Basem; Khurewathanakul, Chitsanu; Klaver, Suzanne; Kochebina, Olga; Kolpin, Michael; Komarov, Ilya; Koopman, Rose; Koppenburg, Patrick; Korolev, Mikhail; Kozlinskiy, Alexandr; Kravchuk, Leonid; Kreplin, Katharina; Kreps, Michal; Krocker, Georg; Krokovny, Pavel; Kruse, Florian; Kucharczyk, Marcin; Kudryavtsev, Vasily; Kurek, Krzysztof; Kvaratskheliya, Tengiz; La Thi, Viet Nga; Lacarrere, Daniel; Lafferty, George; Lai, Adriano; Lambert, Dean; Lambert, Robert W; Lanciotti, Elisa; Lanfranchi, Gaia; Langenbruch, Christoph; Langhans, Benedikt; Latham, Thomas; Lazzeroni, Cristina; Le Gac, Renaud; van Leerdam, Jeroen; Lees, Jean-Pierre; Lefèvre, Regis; Leflat, Alexander; Lefrançois, Jacques; Leo, Sabato; Leroy, Olivier; Lesiak, Tadeusz; Leverington, Blake; Li, Yiming; Liles, Myfanwy; Lindner, Rolf; Linn, Christian; Lionetto, Federica; Liu, Bo; Liu, Guoming; Lohn, Stefan; Longstaff, Iain; Lopes, Jose; Lopez-March, Neus; Lowdon, Peter; Lu, Haiting; Lucchesi, Donatella; Luo, Haofei; Lupato, Anna; Luppi, Eleonora; Lupton, Oliver; Machefert, Frederic; Machikhiliyan, Irina V; Maciuc, Florin; Maev, Oleg; Malde, Sneha; Manca, Giulia; Mancinelli, Giampiero; Manzali, Matteo; Maratas, Jan; Marchand, Jean François; Marconi, Umberto; Marin Benito, Carla; Marino, Pietro; Märki, Raphael; Marks, Jörg; Martellotti, Giuseppe; Martens, Aurelien; Martín Sánchez, Alexandra; Martinelli, Maurizio; Martinez Santos, Diego; Martinez Vidal, Fernando; Martins Tostes, Danielle; Massafferri, André; Matev, Rosen; Mathe, Zoltan; Matteuzzi, Clara; Mazurov, Alexander; McCann, Michael; McCarthy, James; McNab, Andrew; McNulty, Ronan; McSkelly, Ben; Meadows, Brian; Meier, Frank; Meissner, Marco; Merk, Marcel; Milanes, Diego Alejandro; Minard, Marie-Noelle; Molina Rodriguez, Josue; Monteil, Stephane; Moran, Dermot; Morandin, Mauro; Morawski, Piotr; Mordà, Alessandro; Morello, Michael Joseph; Moron, Jakub; Mountain, Raymond; Muheim, Franz; Müller, Katharina; Muresan, Raluca; Muster, Bastien; Naik, Paras; Nakada, Tatsuya; Nandakumar, Raja; Nasteva, Irina; Needham, Matthew; Neri, Nicola; Neubert, Sebastian; Neufeld, Niko; Neuner, Max; Nguyen, Anh Duc; Nguyen, Thi-Dung; Nguyen-Mau, Chung; Nicol, Michelle; Niess, Valentin; Niet, Ramon; Nikitin, Nikolay; Nikodem, Thomas; Novoselov, Alexey; Oblakowska-Mucha, Agnieszka; Obraztsov, Vladimir; Oggero, Serena; Ogilvy, Stephen; Okhrimenko, Oleksandr; Oldeman, Rudolf; Onderwater, Gerco; Orlandea, Marius; Otalora Goicochea, Juan Martin; Owen, Patrick; Oyanguren, Maria Arantza; Pal, Bilas Kanti; Palano, Antimo; Palombo, Fernando; Palutan, Matteo; Panman, Jacob; Papanestis, Antonios; Pappagallo, Marco; Parkes, Christopher; Parkinson, Christopher John; Passaleva, Giovanni; Patel, Girish; Patel, Mitesh; Patrignani, Claudia; Pazos Alvarez, Antonio; Pearce, Alex; Pellegrino, Antonio; Pepe Altarelli, Monica; Perazzini, Stefano; Perez Trigo, Eliseo; Perret, Pascal; Perrin-Terrin, Mathieu; Pescatore, Luca; Pesen, Erhan; Petridis, Konstantin; Petrolini, Alessandro; Picatoste Olloqui, Eduardo; Pietrzyk, Boleslaw; Pilař, Tomas; Pinci, Davide; Pistone, Alessandro; Playfer, Stephen; Plo Casasus, Maximo; Polci, Francesco; Poluektov, Anton; Polycarpo, Erica; Popov, Alexander; Popov, Dmitry; Popovici, Bogdan; Potterat, Cédric; Powell, Andrew; Prisciandaro, Jessica; Pritchard, Adrian; Prouve, Claire; Pugatch, Valery; Puig Navarro, Albert; Punzi, Giovanni; Qian, Wenbin; Rachwal, Bartolomiej; Rademacker, Jonas; Rakotomiaramanana, Barinjaka; Rama, Matteo; Rangel, Murilo; Raniuk, Iurii; Rauschmayr, Nathalie; Raven, Gerhard; Reichert, Stefanie; Reid, Matthew; dos Reis, Alberto; Ricciardi, Stefania; Richards, Alexander; Rinnert, Kurt; Rives Molina, Vincente; Roa Romero, Diego; Robbe, Patrick; Rodrigues, Ana Barbara; Rodrigues, Eduardo; Rodriguez Perez, Pablo; Roiser, Stefan; Romanovsky, Vladimir; Romero Vidal, Antonio; Rotondo, Marcello; Rouvinet, Julien; Ruf, Thomas; Ruffini, Fabrizio; Ruiz, Hugo; Ruiz Valls, Pablo; Sabatino, Giovanni; Saborido Silva, Juan Jose; Sagidova, Naylya; Sail, Paul; Saitta, Biagio; Salustino Guimaraes, Valdir; Sanchez Mayordomo, Carlos; Sanmartin Sedes, Brais; Santacesaria, Roberta; Santamarina Rios, Cibran; Santovetti, Emanuele; Sapunov, Matvey; Sarti, Alessio; Satriano, Celestina; Satta, Alessia; Savrie, Mauro; Savrina, Darya; Schiller, Manuel; Schindler, Heinrich; Schlupp, Maximilian; Schmelling, Michael; Schmidt, Burkhard; Schneider, Olivier; Schopper, Andreas; Schune, Marie Helene; Schwemmer, Rainer; Sciascia, Barbara; Sciubba, Adalberto; Seco, Marcos; Semennikov, Alexander; Senderowska, Katarzyna; Sepp, Indrek; Serra, Nicola; Serrano, Justine; Sestini, Lorenzo; Seyfert, Paul; Shapkin, Mikhail; Shapoval, Illya; Shcheglov, Yury; Shears, Tara; Shekhtman, Lev; Shevchenko, Vladimir; Shires, Alexander; Silva Coutinho, Rafael; Simi, Gabriele; Sirendi, Marek; Skidmore, Nicola; Skwarnicki, Tomasz; Smith, Anthony; Smith, Edmund; Smith, Eluned; Smith, Jackson; Smith, Mark; Snoek, Hella; Sokoloff, Michael; Soler, Paul; Soomro, Fatima; Souza, Daniel; Souza De Paula, Bruno; Spaan, Bernhard; Sparkes, Ailsa; Spinella, Franco; Spradlin, Patrick; Stagni, Federico; Stahl, Sascha; Steinkamp, Olaf; Stenyakin, Oleg; Stevenson, Scott; Stoica, Sabin; Stone, Sheldon; Storaci, Barbara; Stracka, Simone; Straticiuc, Mihai; Straumann, Ulrich; Stroili, Roberto; Subbiah, Vijay Kartik; Sun, Liang; Sutcliffe, William; Swientek, Krzysztof; Swientek, Stefan; Syropoulos, Vasileios; Szczekowski, Marek; Szczypka, Paul; Szilard, Daniela; Szumlak, Tomasz; T'Jampens, Stephane; Teklishyn, Maksym; Tellarini, Giulia; Teodorescu, Eliza; Teubert, Frederic; Thomas, Christopher; Thomas, Eric; van Tilburg, Jeroen; Tisserand, Vincent; Tobin, Mark; Tolk, Siim; Tomassetti, Luca; Tonelli, Diego; Topp-Joergensen, Stig; Torr, Nicholas; Tournefier, Edwige; Tourneur, Stephane; Tran, Minh Tâm; Tresch, Marco; Tsaregorodtsev, Andrei; Tsopelas, Panagiotis; Tuning, Niels; Ubeda Garcia, Mario; Ukleja, Artur; Ustyuzhanin, Andrey; Uwer, Ulrich; Vagnoni, Vincenzo; Valenti, Giovanni; Vallier, Alexis; Vazquez Gomez, Ricardo; Vazquez Regueiro, Pablo; Vázquez Sierra, Carlos; Vecchi, Stefania; Velthuis, Jaap; Veltri, Michele; Veneziano, Giovanni; Vesterinen, Mika; Viaud, Benoit; Vieira, Daniel; Vieites Diaz, Maria; Vilasis-Cardona, Xavier; Vollhardt, Achim; Volyanskyy, Dmytro; Voong, David; Vorobyev, Alexey; Vorobyev, Vitaly; Voß, Christian; Voss, Helge; de Vries, Jacco; Waldi, Roland; Wallace, Charlotte; Wallace, Ronan; Walsh, John; Wandernoth, Sebastian; Wang, Jianchun; Ward, David; Watson, Nigel; Webber, Adam Dane; Websdale, David; Whitehead, Mark; Wicht, Jean; Wiedner, Dirk; Wilkinson, Guy; Williams, Matthew; Williams, Mike; Wilson, Fergus; Wimberley, Jack; Wishahi, Julian; Wislicki, Wojciech; Witek, Mariusz; Wormser, Guy; Wotton, Stephen; Wright, Simon; Wu, Suzhi; Wyllie, Kenneth; Xie, Yuehong; Xing, Zhou; Xu, Zhirui; Yang, Zhenwei; Yuan, Xuhao; Yushchenko, Oleg; Zangoli, Maria; Zavertyaev, Mikhail; Zhang, Feng; Zhang, Liming; Zhang, Wen Chao; Zhang, Yanxi; Zhelezov, Alexey; Zhokhov, Anatoly; Zhong, Liang; Zvyagin, Alexander

    2014-01-01

    The kinematic dependences of the relative production rates, $f_{\\Lambda_b^0}/f_d$, of $\\Lambda_b^0$ baryons and $\\bar{B}^0$ mesons are measured using $\\Lambda_b^0 \\rightarrow \\Lambda_c^+ \\pi^-$ and $\\bar{B}^0 \\rightarrow D^+ \\pi^-$ decays. The measurements use proton-proton collision data, corresponding to an integrated luminosity of 1 fb$^{-1}$ at a centre-of-mass energy of 7 TeV, recorded in the forward region with the LHCb experiment. The relative production rates are observed to depend on the transverse momentum, $p_T$, and pseudorapidity, $\\eta$, of the beauty hadron, in the studied kinematic region $1.5 < p_T < 40$ GeV/$c$ and $2 < \\eta < 5$. Using a previous LHCb measurement of $f_{\\Lambda_b^0}/f_d$ in semileptonic decays, the branching fraction $\\mathcal{B}(\\Lambda_b^0 \\rightarrow \\Lambda_c^+ \\pi^-) = \\Big( 4.30 \\pm 0.03 \\,\\, ^{+0.12}_{-0.11} \\pm 0.26 \\pm 0.21 \\Big) \\times 10^{-3}$ is obtained, where the first uncertainty is statistical, the second is systematic, the third is from the prev...

  12. Compositeness of the strange, charm and beauty odd parity $\\Lambda$ states

    CERN Document Server

    Garcia-Recio, C; Nieves, J; Salcedo, L L; Tolos, L

    2015-01-01

    We study the dependence on the quark mass of the compositeness of the lowest-lying odd parity hyperon states. Thus, we pay attention to $\\Lambda-$like states in the strange, charm and beauty, sectors which are dynamically generated using a unitarized meson-baryon model. In the strange sector we use an SU(6) extension of the Weinberg-Tomozawa meson-baryon interaction, and we further implement the heavy-quark spin symmetry to construct the meson-baryon interaction when charmed or beauty hadrons are involved. In the three examined flavor sectors, we obtain two $J^P=1/2^-$ and one $J^P=3/2^-$ $\\Lambda$ states. We find that the $\\Lambda$ states which are bound states (the three $\\Lambda_b$) or narrow resonances (one $\\Lambda(1405)$ and one $\\Lambda_c(2595)$) are well described as molecular states composed of $s$-wave meson-baryon pairs. The $\\frac{1}{2}^-$ wide $\\Lambda(1405)$ and $\\Lambda_c(2595)$ as well as the $\\frac{3}{2}^-$ $\\Lambda(1520)$ and $\\Lambda_c(2625)$ states display smaller compositeness and so they...

  13. $\\Lambda_{QCD}$ from gluon and ghost propagators

    CERN Document Server

    De soto, F; Pène, O; Rodríguez-Quintero, J

    2009-01-01

    Fundamental quantities of QCD, such as the strong coupling and $\\Lambda_{QCD}$, are studied in the framework of lattice QCD with $N_f=2$ twisted mass fermions. In particular, the contact between lattice and continuous calculations is made by comparing the renormalized ghost-gluon vertex in MOM scheme with 4-loop perturbative results. A power correction is needed in order to have agreement between the two descriptions. This suggests the presence of a dimension-two $\\VEV{A^2}$ gluon condensate whose value is found to be higher than in the quanched case.

  14. Wave-Style Token Machines and Quantum Lambda Calculi

    OpenAIRE

    Lago, Ugo Dal; Zorzi, Margherita

    2015-01-01

    Particle-style token machines are a way to interpret proofs and programs, when the latter are written following the principles of linear logic. In this paper, we show that token machines also make sense when the programs at hand are those of a simple quantum lambda-calculus with implicit qubits. This, however, requires generalising the concept of a token machine to one in which more than one particle travel around the term at the same time. The presence of multiple tokens is intimately relate...

  15. Online Anomaly Energy Consumption Detection Using Lambda Architecture

    DEFF Research Database (Denmark)

    Liu, Xiufeng; Iftikhar, Nadeem; Nielsen, Per Sieverts;

    2016-01-01

    With the widely use of smart meters in the energy sector, anomaly detection becomes a crucial mean to study the unusual consumption behaviors of customers, and to discover unexpected events of using energy promptly. Detecting consumption anomalies is, essentially, a real-time big data analytics...... problem, which does data mining on a large amount of parallel data streams from smart meters. In this paper, we propose a supervised learning and statistical-based anomaly detection method, and implement a Lambda system using the in-memory distributed computing framework, Spark and its extension Spark...

  16. $\\Lambda$CDM-type cosmological model and observational constraints

    CERN Document Server

    Goswami, G K; Mishra, Mandwi

    2014-01-01

    In the present work, we have searched the existence of $\\Lambda$CDM-type cosmological model in anisotropic Heckmann-Schucking space-time. The matter source that is responsible for the present acceleration of the universe consist of cosmic fluid with $p = \\omega\\rho$, where $\\omega$ is the equation of state parameter. The Einstein's field equations have been solved explicitly under some specific choice of parameters that isotropizes the model under consideration. It has been found that the derived model is in good agreement with recent SN Ia observations. Some physical aspects of the model has been discussed in detail.

  17. Epoch-dependent absorption line profile variability in lambda Cep

    CERN Document Server

    Uuh-Sonda, J M; Eenens, P; Mahy, L; Palate, M; Gosset, E; Flores, C A

    2014-01-01

    We present the analysis of a multi-epoch spectroscopic monitoring campaign of the O6Ief star lambda Cep. Previous observations reported the existence of two modes of non-radial pulsations in this star. Our data reveal a much more complex situation. The frequency content of the power spectrum considerably changes from one epoch to the other. We find no stable frequency that can unambiguously be attributed to pulsations. The epoch-dependence of the frequencies and variability patterns are similar to what is seen in the wind emission lines of this and other Oef stars, suggesting that both phenomena likely have the same, currently still unknown, origin.

  18. Horava-Lifshitz gravity with $\\lambda\\to\\infty$

    CERN Document Server

    Gumrukcuoglu, A Emir

    2011-01-01

    In the framework of the power-counting renormalizable theory of gravitation, recently proposed by Ho\\v{r}ava, we study the limit $\\lambda\\to\\infty$, which is arguably the most natural candidate for the ultraviolet fixed point of the renormalization group flow. In the projectable version with dynamical critical exponent $z=3$, we analyze the Friedmann-Robertson-Walker background driven by the so-called "dark matter as integration constant" and perturbations around it. We show that amplitudes of quantum fluctuations for both scalar and tensor gravitons remain finite in the limit and that the theory is weakly coupled under a certain condition.

  19. Teleportation of Atomic States for Atoms in a Lambda Configuration

    CERN Document Server

    Guerra, E S

    2004-01-01

    In this article we discuss a scheme of teleportation of atomic states making use of three-level lambda atoms. The experimental realization proposed makes use of cavity QED involving the interaction of Rydberg atoms with a micromaser cavity prepared in a coherent state. We start presenting a scheme to prepare atomic EPR states involving two-level atoms via the interaction of these atoms with a cavity. In our scheme the cavity and some atoms play the role of auxiliary systems used to achieve the teleportation.

  20. Categorical Models for a Semantically Linear Lambda-calculus

    OpenAIRE

    Marco Gaboardi; Mauro Piccolo

    2010-01-01

    This paper is about a categorical approach to model a very simple Semantically Linear lambda calculus, named Sll-calculus. This is a core calculus underlying the programming language SlPCF. In particular, in this work, we introduce the notion of Sll-Category, which is able to describe a very large class of sound models of Sll-calculus. Sll-Category extends in the natural way Benton, Bierman, Hyland and de Paiva's Linear Category, in order to soundly interpret all the constructs of Sll-calculu...

  1. Lineal: A linear-algebraic lambda-calculus

    OpenAIRE

    Arrighi, Pablo; Dowek, Gilles

    2013-01-01

    We provide a computational definition of the notions of vector space and bilinear functions. We use this result to introduce a minimal language combining higher-order computation and linear algebra. This language extends the Lambda-calculus with the possibility to make arbitrary linear combinations of terms alpha.t + beta.u. We describe how to "execute" this language in terms of a few rewrite rules, and justify them through the two fundamental requirements that the language be a language of l...

  2. Extended CIII] $\\lambda$1909 emission in Q0957+561

    CERN Document Server

    Mediavilla, E; Arribas, S; Falco, E E; Oscoz, A; Serra-Ricart, M; Alcalde, D; Goicoechea, L J; Ramella, M; Barrena, R

    1999-01-01

    2D spectroscopy of Q0957+561 in the CIII]lambda1909 emission line reveals a rich variety of spatially extended features. We point out: (i) a blueshifted region apparently connecting the A and B compact images; (ii) an almost complete arc in the West side which fits well with the infrared arc detected by the Hubble Space Telescope and (iii) traces of extended emission in the East side which could be the fragments of a larger arc-shaped structure. These features should be explained by the current lens models.

  3. Definable functions in the simply typed lambda-calculus

    OpenAIRE

    Zakrzewski, Mateusz

    2007-01-01

    It is a common knowledge that the integer functions definable in simply typed lambda-calculus are exactly the extended polynomials. This is indeed the case when one interprets integers over the type (p->p)->p->p where p is a base type and/or equality is taken as beta-conversion. It is commonly believed that the same holds for beta-eta equality and for integers represented over any fixed type of the form (t->t)->t->t. In this paper we show that this opinion is not quite true. We prove that the...

  4. Innate and adaptive immunity in bacteria: mechanisms of programmed genetic variation to fight bacteriophages.

    Science.gov (United States)

    Bikard, David; Marraffini, Luciano A

    2012-02-01

    Bacteria are constantly challenged by bacteriophages (viruses that infect bacteria), the most abundant microorganism on earth. Bacteria have evolved a variety of immunity mechanisms to resist bacteriophage infection. In response, bacteriophages can evolve counter-resistance mechanisms and launch a 'virus versus host' evolutionary arms race. In this context, rapid evolution is fundamental for the survival of the bacterial cell. Programmed genetic variation mechanisms at loci involved in immunity against bacteriophages generate diversity at a much faster rate than random point mutation and enable bacteria to quickly adapt and repel infection. Diversity-generating retroelements (DGRs) and phase variation mechanisms enhance the generic (innate) immune response against bacteriophages. On the other hand, the integration of small bacteriophage sequences in CRISPR loci provide bacteria with a virus-specific and sequence-specific adaptive immune response. Therefore, although using different molecular mechanisms, both prokaryotes and higher organisms rely on programmed genetic variation to increase genetic diversity and fight rapidly evolving infectious agents.

  5. Novel Bacteroides host strains for detection of human- and animal-specific bacteriophages in water.

    Science.gov (United States)

    Wicki, Melanie; Auckenthaler, Adrian; Felleisen, Richard; Tanner, Marcel; Baumgartner, Andreas

    2011-03-01

    Bacteriophages active against specific Bacteroides host strains were shown to be suitable for detection of human faecal pollution. However, the practical application of this finding is limited because some specific host strains were restricted to certain geographic regions. In this study, novel Bacteroides host strains were isolated that discriminate human and animal faecal pollution in Switzerland. Two strains specific for bacteriophages present in human faecal contamination and three strains specific for bacteriophages indicating animal faecal contamination were evaluated. Bacteriophages infecting human strains were exclusively found in human wastewater, whereas animal strains detected bacteriophages only in animal waste. The newly isolated host strains could be used to determine the source of surface and spring water faecal contamination in field situations. Applying the newly isolated host Bacteroides thetaiotaomicron ARABA 84 for detection of bacteriophages allowed the detection of human faecal contamination in spring water.

  6. Spectroscopy of neutron-rich hypernucleus, $^{7}_{\\Lambda}$He by electron beam

    CERN Document Server

    Gogami, T; Kawama, D; Achenbach, P; Ahmidouch, A; Albayrak, I; Androic, D; Asaturyan, A; Asaturyan, R; Ates, O; Baturin, P; Badui, R; Boeglin, W; Bono, J; Brash, E; Carter, P; Chiba, A; Christy, E; Danagoulian, S; De Leo, R; Doi, D; Elaasar, M; Ent, R; Fujii, Y; Fujita, M; Furic, M; Gabrielyan, M; Gan, L; Garibaldi, F; Gaskell, D; Gasparian, A; Han, Y; Hashimoto, O; Horn, T; Hu, B; Hungerford, Ed V; Jones, M; Kanda, H; Kaneta, M; Kato, S; Kawai, M; Khanal, H; Kohl, M; Liyanage, A; Luo, W; Maeda, K; Margaryan, A; Markowitz, P; Maruta, T; Matsumura, A; Maxwell, V; Mkrtchyan, A; Mkrtchyan, H; Nagao, S; Nakamura, S N; Narayan, A; Neville, C; Niculescu, G; Niculescu, M I; Nunez, A; Nuruzzaman,; Okayasu, Y; Petkovic, T; Pochodzalla, J; Qiu, X; Reinhold, J; Rodriguez, V M; Samanta, C; Sawatzky, B; Seva, T; Shichijo, A; Tadevosyan, V; Tang, L; Taniya, N; Tsukada, K; Veilleux, M; Vulcan, W; Wesselmann, F R; Wood, S A; Yamamoto, T; Ya, L; Ye, Z; Yokota, K; Yuan, L; Zhamkochyan, S; Zhu, L

    2016-01-01

    The missing mass spectroscopy of the $^{7}_{\\Lambda}$He hypernucleus was performed, using the $^{7}$Li$(e,e^{\\prime}K^{+})^{7}_{\\Lambda}$He reaction at JLab Hall-C. The $\\Lambda$ binding energy of the ground state (1/2$^{+}$) was determined with a smaller error than that of the previous measurement, being $B_{\\Lambda}$ = 5.55 $\\pm$ 0.10(stat.) $\\pm$ 0.11(sys.) MeV. The experiment also provided new insight into charge symmetry breaking in p-shell hypernuclear systems. Finally, a peak at $B_{\\Lambda}$ = 3.65 $\\pm$ 0.20(stat.) $\\pm$ 0.11(sys.) MeV was observed and assigned as a mixture of 3/2$^{+}$ and 5/2$^{+}$ states, confirming the "glue-like" behavior of $\\Lambda$, which makes an unstable state in $^{6}$He stable against neutron emission.

  7. Radiative decays of the Sigma0(1385) and Lambda(1520) hyperons

    CERN Document Server

    Taylor, S; Schumacher, R A; Todor, L; Adams, G; Anciant, E; Anghinolfi, M; Asavapibhop, B; Audit, G; Auger, T; Avakian, H; Bagdasaryan, H; Ball, J P; Barrow, S; Battaglieri, M; Beard, K; Bektasoglu, M; Bellis, M; Berman, Barry L; Bianchi, N; Biselli, A S; Boiarinov, S; Bonner, B E; Bouchigny, S; Bradford, R; Branford, D; Briscoe, W J; Brooks, W K; Burkert, V D; Butuceanu, C; Calarco, J R; Carman, D S; Carnahan, B; Cetina, C; Ciciani, L; Cole, P L; Coleman, A; Cords, D; Corvisiero, P; Crabb, D; Crannell, H; Cummings, J P; De Sanctis, E; De Vita, R; Degtyarenko, P V; Denizli, H; Dennis, L; Dharmawardane, K V; Dhuga, K S; Djalali, C; Dodge, G E; Doughty, D C; Dragovitsch, P; Dugger, M; Dytman, S; Eckhause, M; Egiyan, H; Egiyan, K S; Elouadrhiri, L; Empl, A; Eugenio, P; Fatemi, R; Feuerbach, R J; Ficenec, J; Forest, T A; Funsten, H; Gaff, S J; Gai, M; Gavalian, G; Gilad, S; Gilfoyle, G P; Giovanetti, K L; Girard, P; Gordon, C I O; Griffioen, K; Guidal, M; Guillo, M R; Guo, L; Gyurjyan, V; Hadjidakis, C; Hakobyan, R S; Hardie, J; Heddle, D; Heimberg, P; Hersman, F W; Hicks, K; Hicks, R S; Holtrop, M; Hu, J; Hyde-Wright, C E; Ilieva, Y; Ito, M M; Jenkins, D; Joo, K; Kelley, J H; Khandaker, M; Kim, K Y; Kim, K; Kim, W; Klein, A; Klein, F J; Klimenko, A V; Klusman, M; Kossov, M; Kramer, L H; Kuang, Y; Kuhn, S E; Lachniet, J; Laget, J M; Lawrence, D; Ji Li; Lukashin, K; Manak, J J; Marchand, C; McAleer, S; McCarthy, J; Mecking, B A; Mehrabyan, S S; Melone, J J; Mestayer, M D; Meyer, C A; Mikhailov, K; Minehart, R C; Mirazita, M; Miskimen, R; Morand, L; Morrow, S A; Muccifora, V; Müller, J; Napolitano, J; Nasseripour, R; Nelson, S O; Niccolai, S; Niculescu, G; Niculescu, I; Niczyporuk, B B; Niyazov, R A; Nozar, M; O'Brien, J T; O'Rielly, G V; Osipenko, M; Park, K; Pasyuk, E A; Peterson, G; Philips, S A; Pivnyuk, N; Pocanic, D; Pogorelko, O I; Polli, E; Pozdniakov, S; Preedom, B M; Price, J W; Prok, Y; Protopopescu, D; Qin, L M; Quinn, B; Raue, B A; Riccardi, G; Ricco, G; Ripani, M; Ritchie, B G; Ronchetti, F; Rossi, P; Rowntree, D; Rubin, P D; Sabatie, F; Sabourov, K; Salgado, C; Santoro, J P; Sapunenko, V; Serov, V S; Shafi, A; Sharabyan, Yu G; Shaw, J; Simionatto, S; Skabelin, A V; Smith, E S; Smith, L C; Sober, D I; Spraker, M; Stavinsky, A V; Stepanyan, S; Stoler, P; Strakovsky, I I; Strauch, S; Taiuti, M; Tedeschi, D J; Thoma, U; Thompson, R; Tur, C; Ungaro, M; Vineyard, M F; Vlassov, A V; Wang, K; Weinstein, L B; Weisberg, A; Weller, H; Weygand, D P; Whisnant, C S; Wolin, E; Wood, M H; Yegneswaran, A; Yun, J; Zhang, B; Zhao, J; Zhou, Z

    2005-01-01

    The electromagnetic decays of the Sig0(1385) and Lambda(1520) hyperons were studied in photon-induced reactions gamma p -> K+ Lambda(1116)gamma in the CLAS detector at the Thomas Jefferson National Accelerator Facility. We report the first observation of the radiative decay of the Sig0(1385) and a measurement of the Lambda(1520) radiative decay width. For the Sig0(1385) -> Lambda(1116)gamma transition, we measured a partial width of 479+/-120(stat)+81-100(sys) keV, larger than all of the existing model predictions. For the Lambda(1520) -> Lambda(1116)gamma transition, we obtained a partial width of 167+/-43(stat)+26-12(sys) keV.

  8. Search for direct CP violation in {lambda} and {xi} hyperon decays

    Energy Technology Data Exchange (ETDEWEB)

    White, C. G.; Burnstein, R. A.; Carmack, M.; Chakravorty, A.; Chan, A.; Chen, Y. C.; Choong, W. S.; Clark, K.; Crisler, M.; Drapala, J.; Dukes, E. C.; Durandet, C.; Felix, J.; Gidal, G.; Gustafson, H. R.; Ho, C.; Holmstrom, T.; Huang, M.; James, C.; Jenkins, M.; Kaplan, D. M.; Kou, Z.; Lederman, L. M.; Leros, N.; Longo, M. J.; Lopez, F.; Lopez, G.; Luebke, W.; Luk, K. B.; Nelson, K.; Papavassiliou, V.; Perroud, J. P.; Rajaram, D.; Rubin, H. A.; Saleh, N.; Sheng, J.; Sosa, M.; Teng, P. K.; Turko, B.; Volk, J.; White, S. L.; Yu, C.; Yu, Z.; Zyla, P

    1999-03-01

    A sensitive search for direct CP violation in {upsilon}{sup -} ({xi}-bar{sup +}) and {lambda} ({lambda}-bar) decays is underway at FNAL. Experiment E871 (HyperCP) intends to perform a precision measurement of the angular distribution of protons (anti-protons) with respect to the helicity axis in the rest frame of the {lambda} ({lambda}-bar). The slopes of these distributions give the decay parameters {alpha}{sub {upsilon}}{alpha}{sub {lambda}} and {alpha}{sub {xi}}{sub -bar}{alpha}{sub {lambda}}{sub -bar}. An asymmetry parameter A in terms of these decay parameters has been defined for which a non-zero value would be unambiguous evidence for direct CP violation. Theoretical predictions for A range from no asymmetry up to {approx} 10{sup -3}. HyperCP expects to measure A with an uncertainty of {approx} 2 x 10{sup -4}.

  9. Simultaneous loss of bacteriophage receptor and coaggregation mediator activities in Actinomyces viscosus MG-1.

    OpenAIRE

    Tylenda, C A; Enriquez, E.; Kolenbrander, P. E.; Delisle, A L

    1985-01-01

    Actinomyces bacteriophages were used as tools to study coaggregation between actinomyces and streptococci. Four bacteriophage isolates, phages AV-1, AV-2, AV-3, and 1281, bound to coaggregation group A Actinomyces viscosus and to group E A. naeslundii. No binding to groups B, C, D, or F was observed. Only A. viscosus MG-1 was capable of supporting a productive infection by these phages. Spontaneously occurring bacteriophage-resistant mutants of A. viscosus MG-1 were isolated and were shown to...

  10. Template reporter bacteriophage platform and multiple bacterial detection assays based thereon

    Science.gov (United States)

    Goodridge, Lawrence (Inventor)

    2007-01-01

    The invention is a method for the development of assays for the simultaneous detection of multiple bacteria. A bacteria of interest is selected. A host bacteria containing plasmid DNA from a T even bacteriophage that infects the bacteria of interest is infected with T4 reporter bacteriophage. After infection, the progeny bacteriophage are plating onto the bacteria of interest. The invention also includes single-tube, fast and sensitive assays which utilize the novel method.

  11. Asymmetries in the Production of $\\Lambda_{c}^{+}$ and $\\Lambda_{c}^{-}$ Baryons in 500 GeV/c $\\pi^{-}$ Nucleon Interactions

    CERN Document Server

    Aitala, E M; Anjos, J C; Appel, J A; Ashery, D; Banerjee, S; Bediaga, I; Blaylock, G; Bracker, S B; Burchat, Patricia R; Burnstein, R A; Carter, T; Carvalho, H S; Copty, N K; Cremaldi, L M; Darling, C L; Denisenko, K; Devmal, S C; Fernández, A; Fox, G F; Gagnon, P; Göbel, C; Gounder, K; Halling, A M; Herrera-Corral, G; Hurvits, G; James, C; Kasper, P A; Kwan, S; Langs, D C; Leslie, J; Lundberg, B; Magnin, J; May Tal-Beck, S; Meadows, B; De Mello-Neto, J R T; Mihalcea, D; Milburn, R H; De Miranda, J M; Napier, A; Nguyen, A; de Oliveira, A; O'Shaughnessy, K F; Peng, K C; Perera, L P; Purohit, M V; Quinn, B; Radeztsky, S; Rafatian, A; Reay, N W; Reidy, J J; Dos Reis, A C; Rubin, H A; Sanders, D A; Santha, A K S; Santoro, A F S; Schwartz, A J; Sheaff, M; Sidwell, R A; Simão, F R A; Slaughter, A J; Sokoloff, M D; Solano, J M; Stanton, N R; Stefanski, R J; Stenson, K; Summers, D J; Takach, S F; Thorne, K; Tripathi, A K; Watanabe, S; Weiss-Babai, R; Wiener, J; Witchey, N; Wolin, E; Yang, S M; Yi, D; Yoshida, S; Zaliznyak, R; Zhang, C

    2000-01-01

    We present a measurement of asymmetries in the production of $\\Lambda_c^+$ and $\\Lambda_c^-$ baryons in 500 GeV/c $\\pi^-$--nucleon interactions from the E791 experiment at Fermilab. The asymmetries were measured as functions of Feynman x ($x_F$) and transverse momentum squared ($p_T^2$) using a sample of $1819 \\pm 62$ $\\Lambda_c$'s observed in the decay channel $\\Lambda_c \\to pK^-\\pi^+$. We observe more $\\Lambda_c^+$ than $\\Lambda_c^-$ baryons, with an asymmetry of $(12.7\\pm3.4\\pm1.3) %$ independent of $x_F$ and $p_T^2$ in our kinematical range $(-0.1 < x_F < 0.6$ and $0.0 < p_T^2 < 8.0 (GeV/c)^2$). This $\\Lambda_c$ asymmetry measurement is the first with data in both the positive and negative $x_F$ regions.

  12. A Partial Evaluator for A Parallel Lambda Language

    Institute of Scientific and Technical Information of China (English)

    旷海蓉; 孙永强; 等

    1997-01-01

    This paper describes theoretical and practical aspects of a partial evaluator that treats a parallel lambda language.The parallel language presented is a combination of lambda calculus and message passing communication mechanism.This parallel language can be used to write a programming language's denotational semantics which extracts the paallelism in the program.From this denotational definition of the programming language,the partial evaluator can generate parallel compiler of the language by self-application. The key technique of partial evaluation is binding time analysis that determines in advance which parts of the source program can be evaluated during partial evaluation,and which parts cannot,A binding time analysis is described based upon type inference.A new type chcode in introduced into the type system,which denotes the type of those expressions containing residual channel operations.A well-formedness criterion is given which ensures that partial evaluation not only doesn't commit type errors but also doesn't change the sequence of channel operations.Before binding time analysis,channel analysis is used to analyze the communication relationship between send and receive processes.

  13. Constraints on deviations from {\\Lambda}CDM within Horndeski gravity

    CERN Document Server

    Bellini, Emilio; Jimenez, Raul; Verde, Licia

    2015-01-01

    Recent anomalies found in cosmological datasets such as the low multipoles of the Cosmic Microwave Background or the low redshift amplitude and growth of clustering measured by e.g., abundance of galaxy clusters and redshift space distortions in galaxy surveys, have motivated explorations of models beyond standard {\\Lambda}CDM. Of particular interest are models where general relativity (GR) is modified on large cosmological scales. Here we consider deviations from {\\Lambda}CDM+GR within the context of Horndeski gravity, which is the most general theory of gravity with second derivatives in the equations of motion. We adopt a parametrization in which the four additional Horndeski functions of time {\\alpha}_i(t) are proportional to the cosmological density of dark energy {\\Omega}_DE(t). Constraints on this extended parameter space using a suite of state-of-the art cosmological observations are presented for the first time. Although the theory is able to accommodate the low multipoles of the Cosmic Microwave Bac...

  14. Elements of programming linguistics. Part I, The lambda calculus and its implementation

    OpenAIRE

    MacLennan, Bruce J.

    1982-01-01

    The lambda calculus is used as an introduction to programming language concepts, particularly the concepts of functional programming. Both interpreted and compiled implementations of an extended lambda calculus are discussed. They can be adopted to implementations of Pascal and Lisp. It is shown that traditional stack-based run-time structures can be directly derived from the reduction rules of the lambda calculus. (Author)

  15. Polarization of inclusively produced $\\Lambda_{c}$ in a QCD based hybrid model

    CERN Document Server

    Goldstein, G R

    1999-01-01

    A hybrid model is presented for hadron polarization that is based on perturbative QCD subprocesses and the recombination of polarized quarks to form polarized hadrons. The model, originally applied to polarized $\\Lambda$'s that were inclusively produced by proton beams, is extended to include pion beams and polarized $\\Lambda_c$'s. The resulting polarizations are calculated as functions of $x_F$ and $p_T$ for high energies and are found to be in fair agreement with recent experiments.

  16. Determination of $\\Lambda_{\\bar{MS}}$ from quenched and $N_f = 2$ dynamical QCD

    CERN Document Server

    Booth, S; Horsley, R; Irving, A C; Joó, B; Pickles, S; Pleiter, D; Rakow, P E L; Schierholz, G; Sroczynski, Z; Stüben, H

    2001-01-01

    The scale parameter $\\Lambda_{\\bar{MS}}$ is computed on the lattice in the quenched approximation and for $N_f = 2$ flavors of light dynamical quarks. The dynamical calculation is done with non-perturbatively $O(a)$ improved Wilson fermions. In the continuum limit we obtain $\\Lambda_{\\bar{MS}}^{N_f=0} = 243(1)(10)$ MeV and $\\Lambda_{\\bar{MS}}^{N_f=2} = 203(6)(20)$ MeV, respectively.

  17. The effect of bacteriophages T4 and HAP1 on in vitro melanoma migration

    Directory of Open Access Journals (Sweden)

    Boratyński Janusz

    2009-01-01

    Full Text Available Abstract Background The antibacterial activity of bacteriophages has been described rather well. However, knowledge about the direct interactions of bacteriophages with mammalian organisms and their other, i.e. non-antibacterial, activities in mammalian systems is quite scarce. It must be emphasised that bacteriophages are natural parasites of bacteria, which in turn are parasites or symbionts of mammals (including humans. Bacteriophages are constantly present in mammalian bodies and the environment in great amounts. On the other hand, the perspective of the possible use of bacteriophage preparations for antibacterial therapies in cancer patients generates a substantial need to investigate the effects of phages on cancer processes. Results In these studies the migration of human and mouse melanoma on fibronectin was inhibited by purified T4 and HAP1 bacteriophage preparations. The migration of human melanoma was also inhibited by the HAP1 phage preparation on matrigel. No response of either melanoma cell line to lipopolysaccharide was observed. Therefore the effect of the phage preparations cannot be attributed to lipopolysaccharide. No differences in the effects of T4 and HAP1 on melanoma migration were observed. Conclusion We believe that these observations are of importance for any further attempts to use bacteriophage preparations in antibacterial treatment. The risk of antibiotic-resistant hospital infections strongly affects cancer patients and these results suggest the possibility of beneficial phage treatment. We also believe that they will contribute to the general understanding of bacteriophage biology, as bacteriophages, extremely ubiquitous entities, are in permanent contact with human organisms.

  18. Methods for generation of reporter phages and immobilization of active bacteriophages on a polymer surface

    Science.gov (United States)

    Applegate, Bruce Michael (Inventor); Perry, Lynda Louise (Inventor); Morgan, Mark Thomas (Inventor); Kothapalli, Aparna (Inventor)

    2012-01-01

    Novel reporter bacteriophages are provided. Provided are compositions and methods that allow bacteriophages that are used for specific detection or killing of E. coli 0157:H7 to be propagated in nonpathogenic E. coli, thereby eliminating the safety and security risks of propagation in E. coli 0157:H7. Provided are compositions and methods for attaching active bacteriophages to the surface of a polymer in order to kill target bacteria with which the phage comes into contact. Provided are modified bacteriophages immobilized to a surface, which capture E. coli 0157:H7 and cause the captured cells to emit light or fluorescence, allowing detection of the bacteria in a sample.

  19. Radiative decay of $K^-p$ system and photoproduction of $\\Lambda(1405)$

    OpenAIRE

    Choi, Tae Keun; Kim, Kyung Sik; Yu, Byung Geel

    2009-01-01

    The properties of the $\\Lambda(1405)$ resonance have been investigated from radiative decay of $K^- p\\to Y\\gamma$ and photoproduction $\\gamma p\\to K^+\\Lambda(1405)$ within the framework of the isobar model. For a consistent result with recently measured branching ratios, the axial vector meson $K_1(1270)$ is taken into account. Strong and electromagnetic coupling constants of $\\Lambda(1405)$ are extracted from these branching ratios and are applied to the analysis of $K^+\\Lambda(1405)$ photop...

  20. Relation between shrinkage effect and compression of rotational spectrum in $^7_\\Lambda$Li hypernucleus

    CERN Document Server

    Hagino, K

    2011-01-01

    It has been shown experimentally that the $^6$Li nucleus shrinks by adding a $\\Lambda$ particle while its spectrum is also compressed. We discuss the compatibility of these two effects, contrasting also with a relation between the shrinkage effect and the stability of the spectrum in the $^9_\\Lambda$Be hypernucleus. To this end, we employ two-body $d$-$^5_\\Lambda$He and $\\alpha$-$^5_\\Lambda$He cluster models for the $^7_\\Lambda$Li and $^9_\\Lambda$Be hypernuclei, respectively. We first argue that a Gaussian-like interaction between two clusters leads to a stabilization of the spectrum against an addition of a $\\Lambda$ particle, even though the intercluster distance is reduced. In the case of $^7_\\Lambda$Li, the spin-orbit interaction between the intercluster motion and the deuteron spin has to be considered also. We show that the shrinkage effect makes the expectation value of the spin-orbit potential larger, lowering the excitation energy for the $^6$Li($3^+)\\otimes \\Lambda(1/2^+)$ level.

  1. Phenomenology of the Lambda/Sigma0 production ratio in p p collisions

    OpenAIRE

    Sibirtsev, A.; Haidenbauer, J.; Hammer, H. W.; Meissner, U. G.

    2006-01-01

    We show that the recently measured asymmetry in helicity-angle spectra of the Lambda-hyperons, produced in the reaction pp -->K+ Lambda p reaction, and the energy dependence of the total pp --> K+ Lambda p cross-section can be explained consistently by the same Lambda p final-state interaction. Assuming that there is no final-state interaction in the Sigma(0)p channel, as suggested by the available data for the reaction pp --> K+Sigma(0) p, we can also reproduce the energy dependence of the L...

  2. 3D Multi-Channel Networked Visualization System for National LambdaRail Project

    Data.gov (United States)

    National Aeronautics and Space Administration — National LambdaRail (NLR) offers unprecedented communication capabilities on the National and possibly International levels. Physical Optics Corporation (POC)...

  3. Sensitivity of {\\Lambda} single-particle energies to the {\\Lambda}N spin-orbit coupling and to nuclear core structure in p-shell and sd-shell hypernuclei

    CERN Document Server

    Veselý, P; Hrtánková, J; Mareš, J

    2016-01-01

    We introduce a mean field model based on realistic 2-body baryon interactions and calculate spectra of a set of p-shell and sd-shell {\\Lambda} hypernuclei - 13{\\Lambda}C, 17{\\Lambda}O, 21{\\Lambda}Ne, 29{\\Lambda}Si and 41{\\Lambda}Ca. The hypernuclear spectra are compared with the results of a relativistic mean field (RMF) model and available experimental data. The sensitivity of {\\Lambda} single-particle energies to the nuclear core structure is explored. Special attention is paid to the effect of spin-orbit {\\Lambda}N interaction on the energy splitting of the {\\Lambda} single particle levels 0p3/2 and 0p1/2. In particular, we analyze the contribution of the symmetric (SLS) and the anti-symmetric (ALS) spin-orbit terms to the energy splitting. We give qualitative predictions for the calculated hypernuclei.

  4. Quark model description of the \\Lambda_c(2940)^+ as a molecular D^*N state and the possible existence of the \\Lambda_b(6248)

    CERN Document Server

    Ortega, P G; Fernández, F

    2012-01-01

    The \\Lambda_c(2940)^+ baryon is studied in a constituent quark model as a molecular state composed by nucleons and D^* mesons. A bound state with the right binding energy is found for the J^\\pi=3/2^- channel. The partial widths \\Lambda_c(2940)^+\\to ND and \\Lambda_c(2940)^+\\to \\Sigma_c \\pi are calculated and the results are consistent with the experimental data. Additionally a bottom partner \\bar B^*N is predicted with a mass of 6248 MeV/c^2.

  5. Observation of new states decaying into Lambda(c)(+)Kappa(-)pi(+) and Lambda(c)(+)Kappa(0)/(s)pi(-).

    Science.gov (United States)

    Chistov, R; Abe, K; Abe, K; Adachi, I; Aihara, H; Anipko, D; Aulchenko, V; Aushev, T; Bakich, A M; Balagura, V; Barberio, E; Bay, A; Bedny, I; Belous, K; Bitenc, U; Bizjak, I; Blyth, S; Bondar, A; Bozek, A; Bracko, M; Brodzicka, J; Browder, T E; Chang, M-C; Chao, Y; Chen, A; Chen, K-F; Chen, W T; Cheon, B G; Choi, Y; Choi, Y K; Chuvikov, A; Cole, S; Dalseno, J; Danilov, M; Dash, M; Dragic, J; Drutskoy, A; Eidelman, S; Epifanov, D; Gabyshev, N; Garmash, A; Gershon, T; Go, A; Gokhroo, G; Golob, B; Gorisek, A; Ha, H; Haba, J; Hara, T; Hayasaka, K; Hayashii, H; Hazumi, M; Heffernan, D; Hokuue, T; Hoshi, Y; Hou, S; Hou, W-S; Hsiung, Y B; Iijima, T; Imoto, A; Inami, K; Ishikawa, A; Itoh, R; Iwasaki, M; Iwasaki, Y; Kang, J H; Katayama, N; Kawai, H; Kawasaki, T; Khan, H R; Kichimi, H; Kim, H J; Kim, H O; Kinoshita, K; Korpar, S; Krizan, P; Krokovny, P; Kumar, R; Kuo, C C; Kuzmin, A; Kwon, Y-J; Leder, G; Lee, J; Lesiak, T; Lin, S-W; Liventsev, D; Mandl, F; Marlow, D; Matsumoto, T; Matyja, A; McOnie, S; Mitaroff, W; Miyabayashi, K; Miyake, H; Miyata, H; Miyazaki, Y; Mizuk, R; Moloney, G R; Nagamine, T; Nakano, E; Nakao, M; Nishida, S; Nitoh, O; Nozaki, T; Ogawa, S; Ohshima, T; Okabe, T; Okuno, S; Olsen, S L; Onuki, Y; Ozaki, H; Pakhlov, P; Pakhlova, G; Palka, H; Park, H; Park, K S; Pestotnik, R; Piilonen, L E; Sakai, Y; Schietinger, T; Schneider, O; Schwartz, A J; Seidl, R; Sevior, M E; Shapkin, M; Shibuya, H; Shwartz, B; Sidorov, V; Singh, J B; Sokolov, A; Somov, A; Soni, N; Stanic, S; Staric, M; Stoeck, H; Sumiyoshi, T; Suzuki, S; Takasaki, F; Tamura, N; Tanaka, M; Taylor, G N; Teramoto, Y; Tian, X C; Tikhomirov, I; Tsuboyama, T; Tsukamoto, T; Uehara, S; Uglov, T; Ueno, K; Uno, S; Usov, Y; Varner, G; Villa, S; Wang, C C; Wang, C H; Wang, M-Z; Watanabe, Y; Won, E; Wu, C-H; Xie, Q L; Yabsley, B D; Yamaguchi, A; Yamashita, Y; Yamauchi, M; Zhang, L M; Zhang, Z P

    2006-10-20

    We report the first observation of two charmed strange baryons that decay into Lambda(c)(+)Kappa(-)pi(+). The broader of the two states is measured to have a mass of 2978.5+/-2.1+/-2.0 MeV/c2 and a width of 43.5+/-7.5+/-7.0 MeV/c2. The mass and width of the narrow state are measured to be 3076.7+/-0.9+/-0.5 MeV/c;{2} and 6.2+/-1.2+/-0.8 MeV/c2, respectively. We also perform a search for the isospin partner states that decay into Lambda(c)(+)Kappa(0)/(s)pi(-) and observe a significant signal at the mass of 3082.8+/-1.8+/-1.5 MeV/c2. The data used for this analysis were accumulated at or near the Upsilon(4S) resonance, using the Belle detector at the e+ e- asymmetric-energy collider KEKB. The integrated luminosity of the data sample used is 461.5 fb(-1). PMID:17155385

  6. The nature of [S III]{\\lambda}{\\lambda}9096, 9532 emitters at z = 1.34 and 1.23

    CERN Document Server

    An, F X; Meng, Y Z; Chen, Y; Wen, Z Z; Lü, G L

    2014-01-01

    A study of [S III]$\\lambda\\lambda9096,9532$ emitters at $z$ = 1.34 and 1.23 is presented using our deep narrow-band $H_2S1$ (centered at 2.13 $\\mu$m) imaging survey of the Extended Chandra Deep Field South (ECDFS). We combine our data with multi-wavelength data of ECDFS to build up spectral energy distributions (SEDs) from the $U$ to the $K_{s}$-band for emitter candidates selected with strong excess in $H_2S1 - K_{s}$ and derive photometric redshifts, line luminosities, stellar masses and extinction. A sample of 14 [S III] emitters are identified with $H_2S1<22.8$ and $K_{\\rm s}<24.8$ (AB) over 381 arcmin$^{2}$ area, having [S III] line luminosity $L_{[SIII]}= \\sim 10^{41.5-42.6}$erg s$^{-1}$. None of the [S III] emitters is found to have X-ray counterpart in the deepest Chandra 4 Ms observation, suggesting that they are unlikely powered by AGN. HST/ACS F606W and HST/WFC3 F160W images show their rest-frame UV and optical morphologies. About half of the [S III] emitters are mergers and at least one thir...

  7. Proton-lambda correlations in central Au+Au collisions at sqrt (s_NN)=200 GeV

    CERN Document Server

    Adams, J; Ahammed, Z; Amonett, J; Anderson, B D; Arkhipkin, D; Averichev, G S; Badyal, S K; Bai, Y; Balewski, J; Barannikova, O; Barnby, L S; Baudot, J; Bekele, S; Belaga, V V; Bellingeri-Laurikainen, A; Bellwied, R; Berger, J; Bezverkhny, B I; Bharadwaj, S; Bhasin, A; Bhati, A K; Bhatia, V S; Bichsel, H; Bielcik, J; Bielcikova, J; Billmeier, A; Bland, L C; Blyth, C O; Blyth, S L; Bonner, B E; Botje, M; Boucham, A; Bouchet, J; Brandin, A V; Bravar, A; Bystersky, M; Cadman, R V; Cai, X Z; Caines, H; Calderón de la Barca-Sanchez, M; Castillo, J; Catu, O; Cebra, D; Chajecki, Z; Chaloupka, P; Chattopadhyay, S; Chen, H F; Chen, J H; Chen, Y; Cheng, J; Cherney, M; Chikanian, A; Choi, H A; Christie, W; Coffin, J P; Cormier, T M; Cosentino, M R; Cramer, J G; Crawford, H J; Das, D; Das, S; Daugherity, M; De Moura, M M; De Phillips, M; Dedovich, T G; Derevshchikov, A A; Didenko, L; Dietel, T; Dogra, S M; Dong, W J; Dong, X; Draper, J E; Du, F; Dubey, A K; Dunin, V B; Dunlop, J C; Dutta-Majumdar, M R; Eckardt, V; Edwards, W R; Efimov, L G; Emelianov, V; Engelage, J; Eppley, G; Erazmus, B; Estienne, M; Fachini, P; Faivre, J; Fatemi, R; Fedorisin, J; Filimonov, K; Filip, P; Finch, E; Fine, V; Fisyak, Yu; Fornazier, K S F; Fu, J; Gagliardi, C A; Gaillard, L; Gans, J; Ganti, M S; Geurts, F; Ghazikhanian, V; Ghosh, P; González, J E; Gos, H; Grachov, O; Grebenyuk, O; Grosnick, D P; Guertin, S M; Guo, Y; Gupta, N; Gutíerrez, T D; Hallman, T J; Hamed, A; Hardtke, D; Harris, J W; Heinz, M; Henry, T W; Hepplemann, S; Hippolyte, B; Hirsch, A; Hjort, E; Hoffmann, G W; Horner, M J; Huang, H Z; Huang, S L; Hughes, E W; Humanic, T J; Igo, G; Ishihara, A; Jacobs, P; Jacobs, W W; Jedynak, M; Jiang, H; Jones, P G; Judd, E G; Kabana, S; Kang, K; Kaplan, M; Keane, D; Kechechyan, A; Khodyrev, V Yu; Kim, B C; Kiryluk, J; Kisiel, A; Kislov, E M; Klay, J; Klein, S R; Koetke, D D; Kollegger, T; Kopytine, M; Kotchenda, L; Kowalik, K L; Kravtsov, P; Kravtsov, V I; Krämer, M; Krüger, K; Kuhn, C; Kulikov, A I; Kumar, A; Kutuev, R K; Kuznetsov, A A; Lamont, M A C; Landgraf, J M; Lange, S; Laue, F; Lauret, J; Le Vine, M J; Lebedev, A; Lednicky, R; Lee, C H; Lehocka, S; Li, C; Li, Q; Li, Y; Lin, G; Lindenbaum, S J; Lisa, M A; Liu, F; Liu, H; Liu, J; Liu, L; Liu, Q J; Liu, Z; Ljubicic, T; Llope, W J; Long, H; Longacre, R S; Love, W A; Lu, Y; Ludlam, T; Lynn, D; López-Noriega, M; Ma, G L; Ma, J G; Ma, Y G; Magestro, D; Mahajan, S; Mahapatra, D P; Majka, R; Mangotra, L K; Manweiler, R; Margetis, S; Markert, C; Martin, L; Marx, J N; Matis, H S; Matulenko, Yu A; McClain, C J; McShane, T S; Meissner, F; Melnik, Yu M; Meschanin, A; Miller, M L; Minaev, N G; Mironov, C; Mischke, A; Mishra, D K; Mitchell, J; Mohanty, B; Molnár, L; Moore, C F; Morozov, D A; Munhoz, M G; Nandi, B K; Nayak, S K; Nayak, T K; Nelson, J M; Netrakanti, P K; Nikitin, V A; Nogach, L V; Nurushev, S B; Odyniec, Grazyna Janina; Ogawa, A; Okorokov, V; Oldenburg, M; Olson, D; Pal, S K; Panebratsev, Yu A; Panitkin, S Y; Pavlinov, A I; Pawlak, T; Peitzmann, T; Perevozchikov, V; Perkins, C; Peryt, W; Petrov, V A; Phatak, S C; Picha, R; Planinic, M; Pluta, J; Porile, N; Porter, J; Poskanzer, A M; Potekhin, M V; Potrebenikova, E V; Potukuchi, B V K S; Prindle, D; Pruneau, C A; Putschke, J; Rakness, G; Raniwala, R; Raniwala, S; Ravel, O; Ray, R L; Razin, S V; Reichhold, D M; Reid, J G; Reinnarth, J; Renault, G; Retière, F; Ridiger, A; Ritter, H G; Roberts, J B; Rogachevski, O V; Romero, J L; Rose, A; Roy, C; Ruan, L; Russcher, M J; Sahoo, R; Sakrejda, I; Salur, S; Sandweiss, J; Sarsour, M; Savin, I; Sazhin, P S; Schambach, J; Scharenberg, R P; Schmitz, N; Schweda, K; Seger, J; Selyuzhenkov, I; Sen-Gupta, A; Seyboth, P; Shahaliev, E; Shao, M; Shao, W; Sharma, M; Shen, W Q; Shestermanov, K E; Shimansky, S S; Sichtermann, E P; Simon, F; Singaraju, R N; Smirnov, N; Snellings, R; Sood, G; Sowinski, J; Speltz, J; Spinka, H M; Srivastava, B; Stadnik, A; Stanislaus, T D S; Stock, R; Stolpovsky, A; Strikhanov, M N; Stringfellow, B C; Suaide, A A P; Sugarbaker, E R; Sumbera, M; Surrow, B; Swanger, M; Symons, T J M; Szanto de Toledo, A; Sørensen, P; Tai, A; Takahashi, J; Tang, A H; Tarnowsky, T J; Thein, D; Thomas, J H; Timmins, A R; Timoshenko, S; Tokarev, M; Trainor, T A; Trentalange, S; Tribble, R E; Tsai, O D; Ulery, J; Ullrich, T; Underwood, D G; Van Buren, G; Van Leeuwen, M; Van der Kolk, N; Van der Molen, A M; Varma, R; Vasilev, A N; Vasilevski, I M; Vernet, R; Vigdor, S E; Viyogi, Y P; Vokal, S; Voloshin, S A; Waggoner, W T; Wang, F; Wang, G; Wang, X L; Wang, Y; Wang, Z M; Ward, H; Watson, J W; Webb, J C; Westfall, G D; Wetzler, A; Whitten, C; Wieman, H; Wissink, S W; Witt, R; Wood, J; Wu, J; Xu, N; Xu, Z; Xu, Z Z; Yamamoto, E; Yepes, P; Yoo, I K; Yurevich, V I; Zborovský, I; Zhang, H; Zhang, W M; Zhang, Y; Zhang, Z P; Zhong, C; Zoulkarneev, R; Zoulkarneeva, Y; Zubarev, A N; Zuo, J X

    2006-01-01

    We report on p-Lambda, p-Lambda bar, p bar-Lambda and p bar-Lambda bar correlation functions constructed in central Au-Au collisions at sqrt(s_NN)=200GeV by the STAR experiment at RHIC. The proton and lambda source size is inferred from the p-Lambda and p bar-Lambda bar correlation functions. They are found to be smaller than the pion source size also measured by the STAR detector. This could be a consequence of the collision fireball's collective expansion. The p-Lambda bar and p bar-Lambda correlations, which are measured for the first time, exhibit a large anti-correlation. Annihilation channels and/or a negative real part of the spin-averaged scattering length must be included in the final-state interactions calculation to reproduce the measured correlation function.

  8. STUDIES ON THE BACTERIOPHAGE OF D'HERELLE : IV. CONCERNING THE ONENESS OF THE BACTERIOPHAGE.

    Science.gov (United States)

    Bronfenbrenner, J J; Korb, C

    1925-11-30

    Lytic filtrates, active against Bacillus dysenterioe Shiga, Bacillus coli, Bacillus pestis cavioe, and staphylococcus respectively, proved to be differently affected by changes in hydrogen ion concentration. Anti-staphylococcus lysin was the least resistant of the four, showing deterioration in 3 hours at 7 degrees C. beyond the zone of hydrogen ion concentration limited by C(H) = 6.3 x 10(-5) and C(H) = 1.6 x 10(-9). Under the same conditions, the zone of resistance of anti-coli filtrate lay between C(H) = 2.7 x 10(-3) and C(H) = 2.5 x 10(-11), and that of anti-Shiga between C(H) = 1-7 x 10(-4) and C(H) = 1-3 x 10(-11). Anti-pestis cavioe filtrate was most resistant of the four, retaining its full activity in the zone from C(H) = 1 x 10(-3) to C(H) = 3.5 x 10(-12). The fact that these differences in individual resistance persisted, notwithstanding the repeated passage of lytic filtrates through cultures of bacteria other than those against which they were primarily active, seems to offer evidence in favor of a multiplicity of bacteriophages.

  9. Insights into Bacteriophage Application in Controlling Vibrio Species.

    Science.gov (United States)

    Letchumanan, Vengadesh; Chan, Kok-Gan; Pusparajah, Priyia; Saokaew, Surasak; Duangjai, Acharaporn; Goh, Bey-Hing; Ab Mutalib, Nurul-Syakima; Lee, Learn-Han

    2016-01-01

    Bacterial infections from various organisms including Vibrio sp. pose a serious hazard to humans in many forms from clinical infection to affecting the yield of agriculture and aquaculture via infection of livestock. Vibrio sp. is one of the main foodborne pathogens causing human infection and is also a common cause of losses in the aquaculture industry. Prophylactic and therapeutic usage of antibiotics has become the mainstay of managing this problem, however, this in turn led to the emergence of multidrug resistant strains of bacteria in the environment; which has raised awareness of the critical need for alternative non-antibiotic based methods of preventing and treating bacterial infections. Bacteriophages - viruses that infect and result in the death of bacteria - are currently of great interest as a highly viable alternative to antibiotics. This article provides an insight into bacteriophage application in controlling Vibrio species as well underlining the advantages and drawbacks of phage therapy. PMID:27486446

  10. Bacteriophages as Weapons Against Bacterial Biofilms in the Food Industry.

    Science.gov (United States)

    Gutiérrez, Diana; Rodríguez-Rubio, Lorena; Martínez, Beatriz; Rodríguez, Ana; García, Pilar

    2016-01-01

    Microbiological contamination in the food industry is often attributed to the presence of biofilms in processing plants. Bacterial biofilms are complex communities of bacteria attached to a surface and surrounded by an extracellular polymeric material. Their extreme resistance to cleaning and disinfecting processes is related to a unique organization, which implies a differential bacterial growth and gene expression inside the biofilm. The impact of biofilms on health, and the economic consequences, has promoted the development of different approaches to control or remove biofilm formation. Recently, successful results in phage therapy have boosted new research in bacteriophages and phage lytic proteins for biofilm eradication. In this regard, this review examines the environmental factors that determine biofilm development in food-processing equipment. In addition, future perspectives for the use of bacteriophage-derived tools as disinfectants are discussed. PMID:27375566

  11. Bacteriophages as Weapons Against Bacterial Biofilms in the Food Industry.

    Science.gov (United States)

    Gutiérrez, Diana; Rodríguez-Rubio, Lorena; Martínez, Beatriz; Rodríguez, Ana; García, Pilar

    2016-01-01

    Microbiological contamination in the food industry is often attributed to the presence of biofilms in processing plants. Bacterial biofilms are complex communities of bacteria attached to a surface and surrounded by an extracellular polymeric material. Their extreme resistance to cleaning and disinfecting processes is related to a unique organization, which implies a differential bacterial growth and gene expression inside the biofilm. The impact of biofilms on health, and the economic consequences, has promoted the development of different approaches to control or remove biofilm formation. Recently, successful results in phage therapy have boosted new research in bacteriophages and phage lytic proteins for biofilm eradication. In this regard, this review examines the environmental factors that determine biofilm development in food-processing equipment. In addition, future perspectives for the use of bacteriophage-derived tools as disinfectants are discussed.

  12. Characterization of newly isolated lytic bacteriophages active against Acinetobacter baumannii.

    Directory of Open Access Journals (Sweden)

    Maia Merabishvili

    Full Text Available Based on genotyping and host range, two newly isolated lytic bacteriophages, myovirus vB_AbaM_Acibel004 and podovirus vB_AbaP_Acibel007, active against Acinetobacter baumannii clinical strains, were selected from a new phage library for further characterization. The complete genomes of the two phages were analyzed. Both phages are characterized by broad host range and essential features of potential therapeutic phages, such as short latent period (27 and 21 min, respectively, high burst size (125 and 145, respectively, stability of activity in liquid culture and low frequency of occurrence of phage-resistant mutant bacterial cells. Genomic analysis showed that while Acibel004 represents a novel bacteriophage with resemblance to some unclassified Pseudomonas aeruginosa phages, Acibel007 belongs to the well-characterized genus of the Phikmvlikevirus. The newly isolated phages can serve as potential candidates for phage cocktails to control A. baumannii infections.

  13. Bacteriophages and their implications on future biotechnology: a review

    Directory of Open Access Journals (Sweden)

    Haq Irshad

    2012-01-01

    Full Text Available Abstract Recently it has been recognized that bacteriophages, the natural predators of bacteria can be used efficiently in modern biotechnology. They have been proposed as alternatives to antibiotics for many antibiotic resistant bacterial strains. Phages can be used as biocontrol agents in agriculture and petroleum industry. Moreover phages are used as vehicles for vaccines both DNA and protein, for the detection of pathogenic bacterial strain, as display system for many proteins and antibodies. Bacteriophages are diverse group of viruses which are easily manipulated and therefore they have potential uses in biotechnology, research, and therapeutics. The aim of this review article is to enable the wide range of researchers, scientists, and biotechnologist who are putting phages into practice, to accelerate the progress and development in the field of biotechnology.

  14. Effect of HZE particles and space hadrons on bacteriophages

    Energy Technology Data Exchange (ETDEWEB)

    Iurov, S.S.; Akoev, I.G.; Leonteva, G.A.

    1983-01-01

    The effects of particle radiation of the type encountered in space flight on bacteriophages are investigated. Survival and mutagenesis were followed in dry film cultures or liquid suspensions of T4Br(+) bacteriophage exposed to high-energy (HZE) particles during orbital flight, to alpha particles and accelerator-generated hardrons in the laboratory, and to high-energy cosmic rays at mountain altitudes. The HZE particles and high-energy hadrons are found to have a greater relative biological efficiency than standard gamma radiation, while exhibiting a highly inhomogeneous spatial structure in the observed biological and genetic effects. In addition, the genetic lesions observed are specific to the type of radiation exposure, consisting primarily of deletions and multiple lesions of low revertability, with mode of action depending on the linear energy transfer. 18 references.

  15. Effect of HZE particles and space hadrons on bacteriophages

    Science.gov (United States)

    Yurov, S. S.; Akoev, I. G.; Leont'eva, G. A.

    The effect of high energy (HZE) particles and high energy hadrons on T4Br+ bacteriophage was analyzed. The experiments were done in orbital flight, on high mountains, on an accelerator, and with an alpha particle source. We studied the survival rate of the bacteriophage, the mutation frequency, the mutation spectrum and the revertability under the action of chemical mutagens with a known mechanism of action on DNA. It was found that the biological efficiency of HZE particles and high energy hadrons is greater than that of γ radiation. The spectra of mutations produced by these mutations and the mechanisms of their action are also different. These effects were local, because of the mode of interaction of the radiant energy with biological objects, and depended on the linear energy transfer (LET). The modes have now been experimentally defined.

  16. BACTERIOPHAGE ENDOLYSINS AND THEIR USE IN BIOTECHNOLOGICAL PROCESSES

    Directory of Open Access Journals (Sweden)

    Lenka Tišáková

    2014-02-01

    Full Text Available Bacteriophage endolysins are peptidoglycan hydrolases, produced in the lytic system of bacteriophage in order to lyse host peptidoglycan from within and release virions into the environment. Phages infecting Gram-positive bacteria express endolysin genes with the characteristic modular structure, consisting of at least two functional domains: N-terminal enzymatically active domain (EAD and C-terminal cell wall binding domain (CBD. CBDs specifically recognize ligands and bind to the bacterial cell wall, whereas EAD catalyze lysis of the peptidoglycan bonds. The reveal of endolysin modular structure leads to new opportunities for domain swapping, construction of chimeras and production of specifically engineered recombinant endolysins and their functional domains with the diverse biotechnological applications from without, such as in detection, elimination and biocontrol of pathogens, or as anti-bacterials in experimental therapy.

  17. Bacteriophage exclusion, a new defense system

    Science.gov (United States)

    Barrangou, Rodolphe; van der Oost, John

    2015-01-01

    The ability to withstand viral predation is critical for survival of most microbes. Accordingly, a plethora of phage resistance systems has been identified in bacterial genomes (Labrie et al, 2010), including restriction-modification systems (R-M) (Tock & Dryden, 2005), abortive infection (Abi) (Chopin et al, 2005), Argonaute-based interference (Swarts et al, 2014), as well as clustered regularly interspaced short palindromic repeats (CRISPR) and associated protein (Cas) adaptive immune system (CRISPR-Cas) (Barrangou & Marraffini, 2014; Van der Oost et al, 2014). Predictably, the dark matter of bacterial genomes contains a wealth of genetic gold. A study published in this issue of The EMBO Journal by Goldfarb et al (2015) unveils bacteriophage exclusion (BREX) as a novel, widespread bacteriophage resistance system that provides innate immunity against virulent and temperate phage in bacteria. PMID:25502457

  18. A method for the detection of bacteriophages from ocean water

    Science.gov (United States)

    Moebus, K.

    1980-03-01

    A method for the isolation of bacteriophages from ocean water is described. It precludes sample storage before starting phage-enrichment cultures and provides for the use of 3 sub-samples enriched with organic nutrients after 1, 2 and 3 days of incubation. The method was used with samples collected from 6 m below the surface at 48 stations between the European continental shelf and the Sargasso Sea. With 213 among 931 bacterial isolates about 250 strains of bacteriophages were detected by two methods of different sensitivity. From 14 samples taken east of the Azores 115 host bacteria have been found versus only 98 from 34 samples collected at westerly stations. The employment of more than one sub-sample per station as well as the use of more sensitive phage-detection procedures was found to be more advantageous the lower the concentration of cultivatable bacteria in a sample.

  19. Insights into bacteriophage application in controlling Vibrio species

    Directory of Open Access Journals (Sweden)

    Vengadesh Letchumanan

    2016-07-01

    Full Text Available Bacterial infections from various organisms including Vibrio sp. pose a serious hazard to humans in many forms from clinical infection to affecting the yield of agriculture and aquaculture via infection of livestock. Vibrio sp. is one of the main foodborne pathogens causing human infection and is also a common cause of losses in the aquaculture industry. Prophylactic and therapeutic usage of antibiotics has become the mainstay of managing this problem, however this in turn led to the emergence of multidrug resistant strains of bacteria in the environment; which has raised awareness of the critical need for alternative non antibiotic based methods of preventing and treating bacterial infections. Bacteriophages - viruses that infect and result in the death of bacteria – are currently of great interest as a highly viable alternative to antibiotics. This article provides an insight into bacteriophage application in controlling Vibrio species as well underlining the advantages and drawbacks of phage therapy.

  20. Characterization of newly isolated lytic bacteriophages active against Acinetobacter baumannii.

    Science.gov (United States)

    Merabishvili, Maia; Vandenheuvel, Dieter; Kropinski, Andrew M; Mast, Jan; De Vos, Daniel; Verbeken, Gilbert; Noben, Jean-Paul; Lavigne, Rob; Vaneechoutte, Mario; Pirnay, Jean-Paul

    2014-01-01

    Based on genotyping and host range, two newly isolated lytic bacteriophages, myovirus vB_AbaM_Acibel004 and podovirus vB_AbaP_Acibel007, active against Acinetobacter baumannii clinical strains, were selected from a new phage library for further characterization. The complete genomes of the two phages were analyzed. Both phages are characterized by broad host range and essential features of potential therapeutic phages, such as short latent period (27 and 21 min, respectively), high burst size (125 and 145, respectively), stability of activity in liquid culture and low frequency of occurrence of phage-resistant mutant bacterial cells. Genomic analysis showed that while Acibel004 represents a novel bacteriophage with resemblance to some unclassified Pseudomonas aeruginosa phages, Acibel007 belongs to the well-characterized genus of the Phikmvlikevirus. The newly isolated phages can serve as potential candidates for phage cocktails to control A. baumannii infections.

  1. Sequence and comparative analysis of Leuconostoc dairy bacteriophages.

    Science.gov (United States)

    Kot, Witold; Hansen, Lars H; Neve, Horst; Hammer, Karin; Jacobsen, Susanne; Pedersen, Per D; Sørensen, Søren J; Heller, Knut J; Vogensen, Finn K

    2014-04-17

    Bacteriophages attacking Leuconostoc species may significantly influence the quality of the final product. There is however limited knowledge of this group of phages in the literature. We have determined the complete genome sequences of nine Leuconostoc bacteriophages virulent to either Leuconostoc mesenteroides or Leuconostoc pseudomesenteroides strains. The phages have dsDNA genomes with sizes ranging from 25.7 to 28.4 kb. Comparative genomics analysis helped classify the 9 phages into two classes, which correlates with the host species. High percentage of similarity within the classes on both nucleotide and protein levels was observed. Genome comparison also revealed very high conservation of the overall genomic organization between the classes. The genes were organized in functional modules responsible for replication, packaging, head and tail morphogenesis, cell lysis and regulation and modification, respectively. No lysogeny modules were detected. To our knowledge this report provides the first comparative genomic work done on Leuconostoc dairy phages.

  2. Insights into Bacteriophage Application in Controlling Vibrio Species

    Science.gov (United States)

    Letchumanan, Vengadesh; Chan, Kok-Gan; Pusparajah, Priyia; Saokaew, Surasak; Duangjai, Acharaporn; Goh, Bey-Hing; Ab Mutalib, Nurul-Syakima; Lee, Learn-Han

    2016-01-01

    Bacterial infections from various organisms including Vibrio sp. pose a serious hazard to humans in many forms from clinical infection to affecting the yield of agriculture and aquaculture via infection of livestock. Vibrio sp. is one of the main foodborne pathogens causing human infection and is also a common cause of losses in the aquaculture industry. Prophylactic and therapeutic usage of antibiotics has become the mainstay of managing this problem, however, this in turn led to the emergence of multidrug resistant strains of bacteria in the environment; which has raised awareness of the critical need for alternative non-antibiotic based methods of preventing and treating bacterial infections. Bacteriophages – viruses that infect and result in the death of bacteria – are currently of great interest as a highly viable alternative to antibiotics. This article provides an insight into bacteriophage application in controlling Vibrio species as well underlining the advantages and drawbacks of phage therapy. PMID:27486446

  3. First observation of the isospin violating decay $J/\\psi\\rightarrow \\Lambda\\bar{\\Sigma}^{0}+c.c.$

    CERN Document Server

    Ablikim, M; Ambrose, D J; An, F F; An, Q; An, Z H; Bai, J Z; Ban, Y; Becker, J; Berger, N; Bertani, M; Bian, J M; Boger, E; Bondarenko, O; Boyko, I; Briere, R A; Bytev, V; Cai, X; Cakir, O; Calcaterra, A; Cao, G F; Cetin, S A; Chang, J F; Chelkov, G; Chen, G; Chen, H S; Chen, J C; Chen, M L; Chen, S J; Chen, Y; Chen, Y B; Cheng, H P; Chu, Y P; Cronin-Hennessy, D; Dai, H L; Dai, J P; Dedovich, D; Deng, Z Y; Denig, A; Denysenko, I; Destefanis, M; Ding, W M; Ding, Y; Dong, L Y; Dong, M Y; Du, S X; Fang, J; Fang, S S; Fava, L; Feldbauer, F; Feng, C Q; Ferroli, R B; Fu, C D; Fu, J L; Gao, Y; Geng, C; Goetzen, K; Gong, W X; Gradl, W; Greco, M; Gu, M H; Gu, Y T; Guan, Y H; Guo, A Q; Guo, L B; Guo, Y P; Han, Y L; Hao, X Q; Harris, F A; He, K L; He, M; He, Z Y; Held, T; Heng, Y K; Hou, Z L; Hu, H M; Hu, J F; Hu, T; Huang, B; Huang, G M; Huang, J S; Huang, X T; Huang, Y P; Hussain, T; Ji, C S; Ji, Q; Ji, X B; Ji, X L; Jia, L K; Jiang, L L; Jiang, X S; Jiao, J B; Jiao, Z; Jin, D P; Jin, S; Jing, F F; Kalantar-Nayestanaki, N; Kavatsyuk, M; Kuehn, W; Lai, W; Lange, J S; Li, C H; Li, Cheng; Li, Cui; Li, D M; Li, F; Li, G; Li, H B; Li, J C; Li, K; Li, Lei; Li, N B; Li, Q J; Li, S L; Li, W D; Li, W G; Li, X L; Li, X N; Li, X Q; Li, X R; Li, Z B; Liang, H; Liang, Y F; Liang, Y T; Liao, G R; Liao, X T; Liu, B J; Liu, C L; Liu, C X; Liu, C Y; Liu, F H; Liu, Fang; Liu, Feng; Liu, H; Liu, H B; Liu, H H; Liu, H M; Liu, H W; Liu, J P; Liu, K Y; Liu, Kai; Liu, Kun; Liu, P L; Liu, S B; Liu, X; Liu, X H; Liu, Y; Liu, Y B; Liu, Z A; Liu, Zhiqiang; Liu, Zhiqing; Loehner, H; Lu, G R; Lu, H J; Lu, J G; Lu, Q W; Lu, X R; Lu, Y P; Luo, C L; Luo, M X; Luo, T; Luo, X L; Lv, M; Ma, C L; Ma, F C; Ma, H L; Ma, Q M; Ma, S; Ma, T; Ma, X Y; Ma, Y; Maas, F E; Maggiora, M; Malik, Q A; Mao, H; Mao, Y J; Mao, Z P; Messchendorp, J G; Min, J; Min, T J; Mitchell, R E; Mo, X H; Morales, C Morales; Motzko, C; Muchnoi, N Yu; Muramatsu, H; Nefedov, Y; Nicholson, C; Nikolaev, I B; Ning, Z; Olsen, S L; Ouyang, Q; Pacetti, S; Park, J W; Pelizaeus, M