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Sample records for axial injection concept

  1. Axial Spondyloarthritis: An Evolving Concept

    Directory of Open Access Journals (Sweden)

    Nelly Ziadé

    2015-07-01

    Full Text Available Axial spondyloarthritis (AxSpA is the prototype of a family of inter-related yet heterogeneous diseases sharing common clinical and genetic manifestations: the spondyloarthritides (SpAs. The condition mainly affects the sacroiliac joints and axial skeleton, and has a clear classification scheme, wider epidemiological data, and distinct therapeutic guidelines when compared with other SpAs. However, the concept of AxSpA has not been immutable over time and has evolved tremendously on many levels over the past decades. This review identifies the evolution of the AxSpA concept at two levels. First, at the level of classification, the old classifications and rationales leading to the current Assessment of SpondyloArthritis international Society (ASAS classification are reviewed, and the advantages and drawbacks are discussed. Second, at the therapeutic level, current and future treatments are described and treatment strategies are discussed.

  2. Measurement of axial injection displacement with trim coil current unbalance

    Science.gov (United States)

    Covo, Michel Kireeff

    2014-08-01

    The Dee probe used for measuring internal radial beam intensity shows large losses inside the radius of 20 cm of the 88 in. cyclotron. The current of the top and bottom innermost trim coil 1 is unbalanced to study effects of the axial injection displacement. A beam profile monitor images the ion beam bunches, turn by turn. The experimental bunch center of mass position is compared with calculations of the magnetic mirror effect displacement and shows good agreement.

  3. Installation and Debugging of the Axial Injection Line for CYCIAE-100

    Institute of Scientific and Technical Information of China (English)

    YAO; Hong-juan; ZHENG; Xia; MA; Ming-wu; PAN; Gao-feng; ZHANG; Su-ping; WU; Long-cheng; CAI; Hong-ru; GE; Tao

    2012-01-01

    <正>An external multi-cusp ion source and an axial injection line are used in CYCIAE-100 cyclotron for extracting and transporting H- beam. The beam is transported by the injection line and bended by a spiralinflector to the median plane of the machine, and begins to be accelerated by Dee voltage. The total length of the injection line and the ion source is 2 781 mm. The injection line is composed of a big vacuum

  4. Experimental investigation of axial plasma injection into a magnetic dipole field

    DEFF Research Database (Denmark)

    Jensen, Vagn Orla

    1968-01-01

    A high-density helium plasma, accelerated from a conical pinch, is injected axially into a magnetic dipole field. Magnetic probe measurements show that, near the axis, a compression of the field is super-imposed on the standard diamagnetic depression. The compression starts downstream and moves...

  5. Unsteady Tip Clearance Flow Pattern in an Isolated Axial Compressor Rotor with Micro Tip Injection

    Institute of Scientific and Technical Information of China (English)

    Shaojuan Geng; Hongwu Zhang; Jingyi Chen; Weiguang Huang

    2007-01-01

    A numerical study of the effect of discrete micro tip injection on unsteady tip clearance flow pattern in an isolated axial compressor rotor is presented, intending to better understand the flow mechanism behind stall control measures that act on tip clearance flow. Under the influence of injection the unsteadiness of self-induced tip clearance flow could be weakened. Also the radial migration of tip clearance vortex is confined to a smaller radial extent near the rotor tip and the trajectory of tip clearance flow is pushed more downstream. So the injection is beneficial to improve compressor stability and increase static pressure rise near rotor tip region. The results of injection with different injected mass flow rates show that for the special type of injector adopted in the paper the effect of injection on tip clearance flow may be different according to the relative strength between these two streams of flow. For a fixed injected mass flow rate, reducing the injector area to increase injection velocity can improve the effect of injection on tip clearance flow and thus the compressor stability. A comparison of calculations between single blade passage and multiple blade passages validates the utility of single passage computations to investigate the tip clearance flow for the case without injection and its interaction with injected flow for the case with tip injection.

  6. Multiobjective Design of Turbo Injection Mode for Axial Flux Motor in Plastic Injection Molding Machine by Particle Swarm Optimization

    Directory of Open Access Journals (Sweden)

    Jian-Long Kuo

    2015-01-01

    Full Text Available This paper proposes a turbo injection mode (TIM for an axial flux motor to apply onto injection molding machine. Since the injection molding machine requires different speed and force parameters setting when finishing a complete injection process. The interleaved winding structure in the motor provides two different injection levels to provide enough injection forces. Two wye-wye windings are designed to switch two control modes conveniently. Wye-wye configuration is used to switch two force levels for the motor. When only one set of wye-winding is energized, field weakening function is achieved. Both of the torque and speed increase under field weakening operation. To achieve two control objectives for torque and speed of the motor, fuzzy based multiple performance characteristics index (MPCI with particle swarm optimization (PSO is used to find out the multiobjective optimal design solution. Both of the torque and speed are expected to be maximal at the same time. Three control factors are selected as studied factors: winding diameter, winding type, and air-gap. Experimental results show that both of the torque and speed increase under the optimal condition. This will provide enough large torque and speed to perform the turbo injection mode in injection process for the injection molding machine.

  7. Fluoroscopic lumbar interlaminar epidural injections in managing chronic lumbar axial or discogenic pain.

    Science.gov (United States)

    Manchikanti, Laxmaiah; Cash, Kimberly A; McManus, Carla D; Pampati, Vidyasagar; Benyamin, Ramsin

    2012-01-01

    Among the multiple causes of chronic low back pain, axial and discogenic pain are common. Various modalities of treatments are utilized in managing discogenic and axial low back pain including epidural injections. However, there is a paucity of evidence regarding the effectiveness, indications, and medical necessity of any treatment modality utilized for managing axial or discogenic pain, including epidural injections. In an interventional pain management practice in the US, a randomized, double-blind, active control trial was conducted. The objective was to assess the effectiveness of lumbar interlaminar epidural injections of local anesthetic with or without steroids for managing chronic low back pain of discogenic origin. However, disc herniation, radiculitis, facet joint pain, or sacroiliac joint pain were excluded. Two groups of patients were studied, with 60 patients in each group receiving either local anesthetic only or local anesthetic mixed with non-particulate betamethasone. Primary outcome measures included the pain relief-assessed by numeric rating scale of pain and functional status assessed by the, Oswestry Disability Index, Secondary outcome measurements included employment status, and opioid intake. Significant improvement or success was defined as at least a 50% decrease in pain and disability. Significant improvement was seen in 77% of the patients in Group I and 67% of the patients in Group II. In the successful groups (those with at least 3 weeks of relief with the first two procedures), the improvement was 84% in Group I and 71% in Group II. For those with chronic function-limiting low back pain refractory to conservative management, it is concluded that lumbar interlaminar epidural injections of local anesthetic with or without steroids may be an effective modality for managing chronic axial or discogenic pain. This treatment appears to be effective for those who have had facet joints as well as sacroiliac joints eliminated as the pain source.

  8. Fluoroscopic lumbar interlaminar epidural injections in managing chronic lumbar axial or discogenic pain

    Directory of Open Access Journals (Sweden)

    Manchikanti L

    2012-08-01

    Full Text Available Laxmaiah Manchikanti,1,2 Kimberly A Cash,1 Carla D McManus,1 Vidyasagar Pampati,1 Ramsin Benyamin3,41Pain Management Center of Paducah, Paducah, KY; 2University of Louisville, Louisville, KY; 3Millennium Pain Center, Bloomington, IL; 4University of Illinois, Urbana-Champaign, IL, USAAbstract: Among the multiple causes of chronic low back pain, axial and discogenic pain are common. Various modalities of treatments are utilized in managing discogenic and axial low back pain including epidural injections. However, there is a paucity of evidence regarding the effectiveness, indications, and medical necessity of any treatment modality utilized for managing axial or discogenic pain, including epidural injections. In an interventional pain management practice in the US, a randomized, double-blind, active control trial was conducted. The objective was to assess the effectiveness of lumbar interlaminar epidural injections of local anesthetic with or without steroids for managing chronic low back pain of discogenic origin. However, disc herniation, radiculitis, facet joint pain, or sacroiliac joint pain were excluded. Two groups of patients were studied, with 60 patients in each group receiving either local anesthetic only or local anesthetic mixed with non-particulate betamethasone. Primary outcome measures included the pain relief-assessed by numeric rating scale of pain and functional status assessed by the, Oswestry Disability Index, Secondary outcome measurements included employment status, and opioid intake. Significant improvement or success was defined as at least a 50% decrease in pain and disability. Significant improvement was seen in 77% of the patients in Group I and 67% of the patients in Group II. In the successful groups (those with at least 3 weeks of relief with the first two procedures, the improvement was 84% in Group I and 71% in Group II. For those with chronic function-limiting low back pain refractory to conservative management

  9. A high resolution TOF-PET concept with axial geometry and digital SiPM readout

    CERN Document Server

    Casella, C; Joram, C; Schneider, T

    2014-01-01

    The axial arrangement of long scintillation crystals is a promising concept in PET instrumentation to address the need for optimized resolution and sensitivity. Individual crystal readout and arrays of wavelength shifter strips placed orthogonally to the crystals lead to a 3D-detection of the annihilations photons. A fully operational demonstrator scanner, developed by the AX-PET collaboration, proved the potential of this concept in terms of energy and spatial resolution as well as sensitivity. This paper describes a feasibility study, performed on axial prototype detector modules with 100 mm long LYSO crystals, read out by the novel digital Silicon Photomultipliers (dSiPM) from Philips. With their highly integrated readout electronics and excellent intrinsic time resolution, dSiPMs allow for compact, axial detector modules which may extend the potential of the axial PET concept by time of fl ight capabilities (TOF-PET). A coincidence time resolution of 211 ps (FWHM) was achieved in the coincidence of two ax...

  10. The Re-injection Loop concept

    DEFF Research Database (Denmark)

    Holst Fischer, Christian; Malmgren-Hansen, Bjørn; Uellendahl, Hinrich

    There is a huge unexploited biogas potential from manure and agricultural residues in Europe and worldwide. However, these substrates consist of a large fraction of fibres (range 5-80% of dry matter content) with a low methane potential and represent a marginal economy due to their low biogas yie...... fraction. The EU project BIOMAN is currently investigating different technologies for separation, mechanical pretreatment and enzymatic hydrolysis to establish an economically viable concept for manure-based biogas plants....

  11. An Innovative Passive Tip-Leakage Control Method for Axial Turbines: Basic Concept and Performance Potential

    Institute of Scientific and Technical Information of China (English)

    Markus Hamik; Reinhard Willinger

    2007-01-01

    The present paper introduces a new concept for passive turbine tip-leakage control. The basic idea of the method is the connection of the blade leading edge and the blade tip by an internal channel. Due to the difference between the stagnation pressure at the leading edge and the low pressure at the blade tip, a small amount of the working fluid is extracted from the blade passage. At the blade tip, a jet is injected roughly perpendicular to the tip gap flow driven by the blade pressure difference. It is proposed that the jet blocks at least a part of the tip gap flow.Since the tip-leakage losses are proportional to the tip gap mass flow rate, the tip injection results in a reduction of the associated losses. After the introduction of the concept, an analytical model is presented which describes the reduction of the tip gap discharge coefficient due to the tip injection. Furthermore, the analytical model is supported by the results of a preliminary CFD analysis. Finally, the potential of the efficiency improvement by the passive blade tip injection method is reported.

  12. Fluoroscopic caudal epidural injections in managing chronic axial low back pain without disc herniation, radiculitis, or facet joint pain

    Directory of Open Access Journals (Sweden)

    Manchikanti L

    2012-10-01

    Full Text Available Laxmaiah Manchikanti,1,2 Kimberly A Cash,1 Carla D McManus,1 Vidyasagar Pampati11Pain Management Center of Paducah, Paducah, 2Department of Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY, USABackground: Chronic low back pain without disc herniation is common. Various modalities of treatments are utilized in managing this condition, including epidural injections. However, there is continued debate on the effectiveness, indications, and medical necessity of any treatment modality utilized for managing axial or discogenic pain, including epidural injections.Methods: A randomized, double-blind, actively controlled trial was conducted. The objective was to evaluate the ability to assess the effectiveness of caudal epidural injections of local anesthetic with or without steroids for managing chronic low back pain not caused by disc herniation, radiculitis, facet joints, or sacroiliac joints. A total of 120 patients were randomized to two groups; one group did not receive steroids (group 1 and the other group did (group 2. There were 60 patients in each group. The primary outcome measure was at least 50% improvement in Numeric Rating Scale and Oswestry Disability Index. Secondary outcome measures were employment status and opioid intake. These measures were assessed at 3, 6, 12, 18, and 24 months after treatment.Results: Significant pain relief and functional status improvement (primary outcome defined as a 50% or more reduction in scores from baseline, were observed in 54% of patients in group 1 and 60% of patients in group 2 at 24 months. In contrast, 84% of patients in group 1 and 73% in group 2 saw significant pain relief and functional status improvement in the successful groups at 24 months.Conclusion: Caudal epidural injections of local anesthetic with or without steroids are effective in patients with chronic axial low back pain of discogenic origin without facet joint pain, disc herniation, and

  13. Fluoroscopic lumbar interlaminar epidural injections in managing chronic lumbar axial or discogenic pain

    OpenAIRE

    Manchikanti L; Cash KA; McManus CD; Pampati V; Benyamin R

    2012-01-01

    Laxmaiah Manchikanti,1,2 Kimberly A Cash,1 Carla D McManus,1 Vidyasagar Pampati,1 Ramsin Benyamin3,41Pain Management Center of Paducah, Paducah, KY; 2University of Louisville, Louisville, KY; 3Millennium Pain Center, Bloomington, IL; 4University of Illinois, Urbana-Champaign, IL, USAAbstract: Among the multiple causes of chronic low back pain, axial and discogenic pain are common. Various modalities of treatments are utilized in managing discogenic and axial low back pain including e...

  14. Pressurized air injection in an axial hydro-turbine model for the mitigation of tip leakage cavitation

    Science.gov (United States)

    Rivetti, A.; Angulo, M.; Lucino, C.; Liscia, S.

    2015-12-01

    Tip leakage vortex cavitation in axial hydro-turbines may cause erosion, noise and vibration. Damage due to cavitation can be found at the tip of the runner blades on the low pressure side and the discharge ring. In some cases, the erosion follows an oscillatory pattern that is related to the number of guide vanes. That might suggest that a relationship exists between the flow through the guide vanes and the tip vortex cavitating core that induces this kind of erosion. On the other hand, it is known that air injection has a beneficial effect on reducing the damage by cavitation. In this paper, a methodology to identify the interaction between guide vanes and tip vortex cavitation is presented and the effect of air injection in reducing this particular kind of erosion was studied over a range of operating conditions on a Kaplan scale model. It was found that air injection, at the expense of slightly reducing the efficiency of the turbine, mitigates the erosive potential of tip leakage cavitation, attenuates the interaction between the flow through the guide vanes and the tip vortex and decreases the level of vibration of the structural components.

  15. Xu Fuguan’s Study of the Axial Period in China and the Concept of Concerned Consciousness

    Directory of Open Access Journals (Sweden)

    Téa Sernelj

    2016-05-01

    Full Text Available Although Xu Fuguan (1903–1982 belongs to the most important representatives of the Modern Confucian intellectual movement he is rather unknown outside China. However, his concept of “concerned consciousness” (youhuan yishi 憂患 意識 is relevant not only for the recognition of the special characteristics which determine the ideological and political structure of ancient Chinese society, but also for the intercultural elaboration of Jaspers’ “axial age” theory. This article introduces the concept to the European academic readership and provides an analysis of its connection to the Modern Confucian hypothesis regarding the absence of an external God (or Deities in classical Chinese culture.

  16. Electrical spin injection and detection in Si nanowires with axial doping gradient

    Science.gov (United States)

    Kountouriotis, Konstantinos; Barreda, Jorge; Keiper, Tim; Zhang, Mei; Xiong, Peng

    Due to the technological importance and potential long spin coherence time in silicon, there have been significant recent efforts to realize spin injection, coherent transport, and electrical spin detection in Si nanowires (NWs). The nature of the electronic transport at the interface and its resistance are crucial factors in realizing efficient spin injection/detection between a ferromagnet (FM) and a semiconductor (SC). In this work, we examine the effects on electrical spin injection and detection by FM/SC interfaces with well-defined Schottky barriers in Si NW devices. The Si NWs are synthesized via a vapor-liquid-solid method using silane and phosphine precursor gases for the growth and doping respectively, which results in a graded phosphorus doping profile along the length of the NW. The Si NWs are dispersed on a p+-Si/SiO2/SiNx substrate, and a series of CoFe electrodes are defined along a Si NW with electron beam lithography and magnetron sputtering after the removal of the native oxide by HF treatment. As a consequence of the doping gradient, the FM electrodes form Ohmic and Schottky barrier contacts of varying heights along the length of a single NW. Two-terminal local and four-terminal non-local spin-valve measurements are performed to probe spin accumulation and transport at different FM contacts, enabling a study of the dependence of the spin signals on the Schottky barrier height and interface resistance on a single device. Work supported by NSF Grant DMR-1308613.

  17. The concept of a plasma centrifuge with a high frequency rotating magnetic field and axial circulation

    Science.gov (United States)

    Borisevich, V. D.; Potanin, E. P.

    2017-07-01

    The possibility of using a rotating magnetic field (RMF) in a plasma centrifuge (PC), with axial circulation to multiply the radial separation effect in an axial direction, is considered. For the first time, a traveling magnetic field (TMF) is proposed to drive an axial circulation flow in a PC. The longitudinal separation effect is calculated for a notional model, using specified operational parameters and the properties of a plasma, comprising an isotopic mixture of 20Ne-22Ne and generated by a high frequency discharge. The optimal intensity of a circulation flow, in which the longitudinal separation effect reaches its maximum value, is studied. The optimal parameters of the RMF and TMF for effective separation, as well as the centrifuge performance, are calculated.

  18. Energy reduction: a technique for seed-injection locking of single-axial-mode Q-switched Nd:YAG laser

    Institute of Scientific and Technical Information of China (English)

    Sui Chen; Wenxiong Lin; Fei Shi; Jianhong Huang; Jinhui Li; Hui Zheng; Jipeng Lin; Canhua Xu

    2007-01-01

    A new technique for seed-injection locking of single-axial-mode (SAM) Q-switched Nd:YAG laser is reported. The technique called energy reduction (ER) is utilized when SAM operation is locked to design its feedback scheme. This method ensures long-term 100% seed-injection locking performance and the pulsed SAM output energy can reach as high as 200 mJ. Both temporal and spatial interferometric experiments have been executed to confirm the SAM oscillation.

  19. PM Axial Flux Machine Design for Hybrid Traction Conception d’une machine à flux axial à aimants permanents pour la traction hybride

    Directory of Open Access Journals (Sweden)

    de la Barrière O.

    2009-11-01

    Full Text Available the best ways in order to reduce fuel consumption for vehicles. It consists of associating an electric motor next to the classical thermal machine. In this embedded system, the efficiency and the torque per unit mass are very important. So it seems to be a good idea to use a permanent magnet synchronous machine, which is recognized for satisfying these two objectives. Since the allocated volume is rather flat, axial flux topologies are interesting. This paper’s goal is to propose an optimal first design method for such structures, given the allocated volume and the machine requirements. La traction hybride semble actuellement un des moyens les plus prometteurs pour réduire la consommation de carburant des véhicules. Ce procédé consiste à associer un moteur électrique au moteur thermique traditionnel. Pour une telle application embarquée, le rendement, ainsi que le couple massique, sont des critères de conception de première importance. Dans ce contexte, le recours à une machine synchrone à aimants permanents, reconnue pour satisfaire ces deux critères, semble être approprié. Vu que le volume alloué à la machine électrique est de forme discoïde, les topologies à flux axial semblent les plus intéressantes. L’objectif de cet article est de proposer une méthodologie de pré-dimensionnement de tels actionneurs, en ayant fixé au préalable le volume maximal permis ainsi que le cahier des charges de la machine.

  20. Stall margin improvement of an axial flow fan with end wall injection and suction; Hekimen fukidashi suidashi ni yoru han'yo jikuryu sofuki no shissoku kaizen

    Energy Technology Data Exchange (ETDEWEB)

    Nishioka, K.; Kuroda, H.; Obata, S.; Chimura, O. [National Defense Academy, Kanagawa (Japan)

    1999-06-25

    The experimental studies are conducted to reveal the mechanism of stall margin improvement of an axial flow fan by injection or suction from the end wall. In case of injection, the largest improvement is obtained by the injection at about 0. 14 {approx} 0 .21 times axial chord length downstream from leading edge. The reason for large improvement is that stall vortex, shed intermittent separation vortex and tip leakage vortex are dissipated by this injection, and also that this blowing suppresses the separation of boundary layer. In case of suction, the largest improvement is found for the suction from the end wall near leading edge. The amplitude of periodic static pressure after stall inception becomes smaller in comparison with injection cases. These effects are increased with the increase of suction flow rate, because the discharge of the vortex occurs more easily. On the other hand, the suction from the upstream of leading edge reduces the axial velocity near rotor tip, and then it induces stall. Also we tried to visualize the tip region flow, The suppression mechanism is discussed based on the visualization. The suppression of stall is successfully photographed. (author)

  1. Electron ripple injection concept for tokamak transport control

    Science.gov (United States)

    Choe, W.; Ono, M.; Chang, C. S.

    1996-02-01

    A non-intrusive method for inducing a radial electric field (Er) based on electron ripple injection (ERI) is under development by the Princeton CDX-U group. Since Er is known to play an important role in the L-H and H-VH mode transition, it is therefore important to develop a non-intrusive tool to control the Er profile in tokamak plasmas. The present technique utilizes externally-applied local magnetic ripple fields to trap electrons at the edge, allowing them to penetrate towards the plasma center via ∇B and curvature drifts, causing the flux surfaces to charge up negatively. Electron cyclotron resonance heating (ECRH) is utilized to increase the trapped population and the electron drift velocity by raising the perpendicular energy of trapped electrons. The temperature anisotropy of resonant electrons in a tokamak plasma is calculated in order to investigate effects of ECRH on electrons. Simulations using a guiding-center orbit model have been performed to understand the behavior of suprathermal electrons in the presence of ripple fields. Examples for CDX-U and ITER are given.

  2. Conception preliminaire de disques de turbine axiale pour moteurs d'aeronefs

    Science.gov (United States)

    Ouellet, Yannick

    The preliminary design phase of a turbine rotor has an important impact on the architecture of a new engine definition, as it sets the technical orientation right from start and provides a good estimate of product performance, weight and cost. In addition, the execution speed at this preliminary phase has become critical into capturing business opportunities. Improving upfront accuracy also alleviates downstream detailed design work and therefore reduces overall product development cycle time. This preliminary phase contains elements slowing down its process, including low interoperability of currently used systems, incompatibility of software and ineffective management of data. In order to overcome these barriers, we have developed the first module of a new Design and Analysis (D&A) platform for the rotor disc. This complete platform ensures integration of different tools processing in batch mode, and is driven from a single graphical user interface. The platform developed has been linked with different optimization methods (algorithms, configuration) in order to automate the disc design and propose best practices for rotor structural optimization. This methodology allowed reduction in design cycle time and improvement of performance. It was applied on two reference P&WC axial discs. The platform's architecture was also used in the development of reference charts to better understand disc performance within given design space. Four high pressure rotor discs of P&WC turbofan and turboprop engines were used to generate the technical charts and understand the effect of various parameters. The new tools supporting disc D&A, combined with the optimization process and reference charts, has proven to be profitable in terms of component performance and engineering effort inputs.

  3. Demonstration of an Axial PET concept for brain and small animal imaging

    CERN Document Server

    Beltrame, P; Clinthorne, N; Meddi, F; Kagan, H; Braem, A; Pauss, F; Djambazov, L; Lustermann, W; Weilhammer, P; Nessi-Tedaldi, F; Dissertori, G; Renker, D; Schneider, T; Schinzel, D; De Leo, R; Bolle, E; Fanti, V; Rafecas, M; Rudge, A; Stapnes, S; Casella, C; Chesi, E; Seguinot, J; Solevi, P; Joram, C; Oliver, J F

    2011-01-01

    Standard Positron Emission Tomography (PET) cameras need to reach a compromise between spatial resolution and sensitivity. To overcome this limitation we developed a novel concept of PET. Our AX-PET demonstrator is made of LYSO crystals aligned along the z coordinate (patient's axis) and WLS strips orthogonally placed with respect to the crystals. This concept offers full 3D localization of the photon interaction inside the camera. Thus the spatial resolution and the sensitivity can be simultaneously improved and the reconstruction of Compton interactions inside the detector is also possible. Moreover, by means of G-APDs for reading out the photons, both from LYSO and WLS, the detector is insensitive to magnetic fields and it is then suitable to be used in a combined PET/MRI apparatus. A complete Monte Carlo simulation and dedicated reconstruction software have been developed. The two final modules, each composed of 48 crystals and 156 WLS strips, have been built and fully characterized in a dedicated test se...

  4. Numerical Investigation of Active Tip-clearance Control through Tip Cooling Injection in an Axial Turbine Cascade

    Institute of Scientific and Technical Information of China (English)

    Maosheng Niu; Shusheng Zang

    2009-01-01

    This paper presents a numerical investigation of an active tip-clearance control method based on cooling injection from the blade tip surface. It aims to study the influences of air injection on controlling tip clearance flow, with emphasis on the effects of the injection location on secondary flow and the potential thermal benefits from the cooling jet. The results show that injection location plays an important role in the redistribution of secondary flow within the cascade passage. Injection located much closer to the pressure-side comer performs better in reducing tip clearance massflow and its associated losses. However, it also intensifies tip passage vortex, due to less re-straint deriving from the reduced tip clearance vortex. Lower plenum total pressure is required to inject equivalent amount of cooling air, but the heat transfer condition on the blade tip surface is a bit worse than that with injection from the reattachment region. Thus the optimum location of air injection should be at the tip separation vortex re-gion.

  5. Nuclear Safety Functions of ITER Gas Injection System Instrumentation and Control and the Concept Design

    Science.gov (United States)

    Yang, Yu; Maruyama, S.; Fossen, A.; Villers, F.; Kiss, G.; Zhang, Bo; Li, Bo; Jiang, Tao; Huang, Xiangmei

    2016-08-01

    The ITER Gas Injection System (GIS) plays an important role on fueling, wall conditioning and distribution for plasma operation. Besides that, to support the safety function of ITER, GIS needs to implement three nuclear safety Instrumentation and Control (I&C) functions. In this paper, these three functions are introduced with the emphasis on their latest safety classifications. The nuclear I&C design concept is briefly discussed at the end.

  6. Fluoroscopic cervical epidural injections in chronic axial or disc-related neck pain without disc herniation, facet joint pain, or radiculitis

    Directory of Open Access Journals (Sweden)

    Manchikanti L

    2012-07-01

    Full Text Available Laxmaiah Manchikanti, Kimberly A Cash, Vidyasagar Pampati, Yogesh MallaPain Management Center of Paducah, Paducah, KY, USABackground: While chronic neck pain is a common problem in the adult population, with a typical 12-month prevalence of 30%–50%, there is a lack of consensus regarding its causes and treatment. Despite limited evidence, cervical epidural injections are one of the commonly performed nonsurgical interventions in the management of chronic neck pain.Methods: A randomized, double-blind, active, controlled trial was conducted to evaluate the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of chronic neck pain with or without upper extremity pain in patients without disc herniation, radiculitis, or facet joint pain.Results: One hundred and twenty patients without disc herniation or radiculitis and negative for facet joint pain by means of controlled diagnostic medial branch blocks were randomly assigned to one of two treatment groups, ie, injection of local anesthetic only (group 1 or local anesthetic mixed with nonparticulate betamethasone (group 2. The primary outcome of significant pain relief and improvement in functional status (≥50% was demonstrated in 72% of group 1 and 68% of group 2. The overall average number of procedures per year was 3.6 in both groups with an average total relief per year of 37–39 weeks in the successful group over a period of 52 weeks.Conclusion: Cervical interlaminar epidural injections of local anesthetic with or without steroids may be effective in patients with chronic function-limiting discogenic or axial pain.Keywords: chronic neck pain, cervical disc herniation, cervical discogenic pain, cervical epidural injections, epidural steroids, local anesthetics

  7. Flash Atomization: A New Concept to Control Combustion Instability in Water-Injected Gas Turbines

    Directory of Open Access Journals (Sweden)

    Vishwas Iyengar

    2012-01-01

    Full Text Available The objective of this work is to explore methods to reduce combustor rumble in a water-injected gas turbine. Attempts to use water injection as a means to reduce NOX emissions in gas turbines have been largely unsuccessful because of increased combustion instability levels. This pulsation causes chronic fretting, wear, and fatigue that damages combustor components. Of greater concern is that liberated fragments could cause extensive damage to the turbine section. Combustion instability can be tied to the insufficient atomization of injected water; large water droplets evaporate non-uniformly that lead to energy absorption in chaotic pulses. Added pulsation is amplified by the combustion process and acoustic resonance. Effervescent atomization, where gas bubbles are injected, is beneficial by producing finely atomized droplets; the gas bubbles burst as they exit the nozzles creating additional energy to disperse the liquid. A new concept for effervescent atomization dubbed “flash atomization” is presented where water is heated to just below its boiling point in the supply line so that some of it will flash to steam as it leaves the nozzle. An advantage of flash atomization is that available heat energy can be used rather than mechanical energy to compress injection gas for conventional effervescent atomization.

  8. Fluoroscopic caudal epidural injections in managing chronic axial low back pain without disc herniation, radiculitis, or facet joint pain

    OpenAIRE

    Manchikanti L; Cash KA; McManus CD; Pampati V

    2012-01-01

    Laxmaiah Manchikanti,1,2 Kimberly A Cash,1 Carla D McManus,1 Vidyasagar Pampati11Pain Management Center of Paducah, Paducah, 2Department of Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY, USABackground: Chronic low back pain without disc herniation is common. Various modalities of treatments are utilized in managing this condition, including epidural injections. However, there is continued debate on the effectiveness, indications, and medical necessity of ...

  9. A non-axial superconducting magnet design for optimized patient access and minimal SAD for use in a Linac-MR hybrid: proof of concept

    Science.gov (United States)

    Yaghoobpour Tari, Shima; Wachowicz, Keith; Fallone, B. Gino

    2017-04-01

    A prototype rotating hybrid magnetic resonance imaging system and linac has been developed to allow for simultaneous imaging and radiation delivery parallel to B 0. However, the design of a compact magnet capable of rotation in a small vault with sufficient patient access and a typical clinical source-to-axis distance (SAD) is challenging. This work presents a novel superconducting magnet design as a proof of concept that allows for a reduced SAD and ample patient access by moving the superconducting coils to the side of the yoke. The yoke and pole-plate structures are shaped to direct the magnetic flux appropriately. The outer surface of the pole plate is optimized subject to the minimization of a cost function, which evaluates the uniformity of the magnetic field over an ellipsoid. The magnetic field calculations required in this work are performed with the 3D finite element method software package Opera-3D. Each tentative design strategy is virtually modeled in this software package, which is externally controlled by MATLAB, with its key geometries defined as variables. The optimization variables are the thickness of the pole plate at control points distributed over the pole plate surface. A novel design concept as a superconducting non-axial magnet is introduced, which could create a large uniform B 0 magnetic field with fewer geometric restriction. This non-axial 0.5 T superconducting magnet has a moderately reduced SAD of 123 cm and a vertical patient opening of 68 cm. This work is presented as a proof of principle to investigate the feasibility of a non-axial magnet with the coils located around the yoke, and the results encourage future design optimizations to maximize the benefits of this non-axial design.

  10. A non-axial superconducting magnet design for optimized patient access and minimal SAD for use in a Linac-MR hybrid: proof of concept.

    Science.gov (United States)

    Yaghoobpour Tari, Shima; Wachowicz, Keith; Gino Fallone, B

    2017-04-21

    A prototype rotating hybrid magnetic resonance imaging system and linac has been developed to allow for simultaneous imaging and radiation delivery parallel to B 0. However, the design of a compact magnet capable of rotation in a small vault with sufficient patient access and a typical clinical source-to-axis distance (SAD) is challenging. This work presents a novel superconducting magnet design as a proof of concept that allows for a reduced SAD and ample patient access by moving the superconducting coils to the side of the yoke. The yoke and pole-plate structures are shaped to direct the magnetic flux appropriately. The outer surface of the pole plate is optimized subject to the minimization of a cost function, which evaluates the uniformity of the magnetic field over an ellipsoid. The magnetic field calculations required in this work are performed with the 3D finite element method software package Opera-3D. Each tentative design strategy is virtually modeled in this software package, which is externally controlled by MATLAB, with its key geometries defined as variables. The optimization variables are the thickness of the pole plate at control points distributed over the pole plate surface. A novel design concept as a superconducting non-axial magnet is introduced, which could create a large uniform B 0 magnetic field with fewer geometric restriction. This non-axial 0.5 T superconducting magnet has a moderately reduced SAD of 123 cm and a vertical patient opening of 68 cm. This work is presented as a proof of principle to investigate the feasibility of a non-axial magnet with the coils located around the yoke, and the results encourage future design optimizations to maximize the benefits of this non-axial design.

  11. A concept for non-invasive temperature measurement during injection moulding processes

    Energy Technology Data Exchange (ETDEWEB)

    Hopmann, Christian; Spekowius, Marcel, E-mail: spekowius@ikv.rwth-aachen.de; Wipperfürth, Jens; Schöngart, Maximilian, E-mail: schoengart@ikv.rwth-aachen.de [Institute of Plastics Processing (IKV), RWTH Aachen University Pontstr. 49, 52062 Aachen (Germany)

    2016-03-09

    Current models of the injection moulding process insufficiently consider the thermal interactions between melt, solidified material and the mould. A detailed description requires a deep understanding of the underlying processes and a precise observation of the temperature. Because todays measurement concepts do not allow a non-invasive analysis it is necessary to find new measurement techniques for temperature measurements during the manufacturing process. In this work we present the idea of a set up for a tomographic ultrasound measurement of the temperature field inside a plastics melt. The goal is to identify a concept that can be installed on a specialized mould for the injection moulding process. The challenges are discussed and the design of a prototype is shown. Special attention is given to the spatial arrangement of the sensors. Besides the design of a measurement set up a reconstruction strategy for the ultrasound signals is required. We present an approach in which an image processing algorithm can be used to calculate a temperature distribution from the ultrasound scans. We discuss a reconstruction strategy in which the ultrasound signals are converted into a spartial temperature distribution by using pvT curves that are obtained by dilatometer measurements.

  12. Linear bunchers on the SFC axial injection line%SFC轴向注入线上的线性聚束器

    Institute of Scientific and Technical Information of China (English)

    唐靖宇; 蒋君章; 石爱民; 阴祖康; 黄廷泽; 聂玉珠

    2000-01-01

    A two-gap drift tube buncher and a one-gap grid buncher with linear bunching waveform are used on the SFC axial injection line. The method of charge-discharge is adopted to get high voltage RF linear waveform. Working at the half-frequency bunching mode, the two bunchers can increase the theoretical longitudinal matching efficiency between the injector and the main cyclotron to 100% at any working mode.%SFC轴向注入线采用了一个双间隙漂移管式聚束器和一个单间隙栅网型聚束器,分别采用三角波和锯齿波的聚束波形。采用充放电式的高频电压发生器可以得到要求的聚束电压。这两台聚束器采用半频聚束模式,可以将两台回旋加速器的理论纵向匹配效率在所有工作模式下都提高到100%。

  13. Thermal and enzymatic treatment of digested manure fibers in the re-injection loop concept to increase biogas yields

    DEFF Research Database (Denmark)

    Escobar, Esperanza Jurado; Uellendahl, Hinrich Wilhelm; Njoku, Stephen Ikechukwu

    2015-01-01

    treatment of the digested manure fibers (DMF) in combination with the re-injection loop concept were tested. Thermal treatment of DMF at 105oC showed an increase of the specific methane yield of DMF by 65% while no siginificant effect was observed for enzymatic treatment of DMF for 1 h prior......The re-injection loop concept proposes the recirculation of lignocellulosic organic matter after a first cycle of anaerobic digestion in order to increase the conversion into biogas. This re-circulation can potentially increase the methane yield up to 20%. In this study thermal and enzymatic...

  14. The assessment of the spondyloarthritis international society concept and criteria for the classification of axial spondyloarthritis and peripheral spondyloarthritis: A critical appraisal for the pediatric rheumatologist

    Directory of Open Access Journals (Sweden)

    Burgos-Vargas Ruben

    2012-05-01

    Full Text Available Abstract This review refers to the origin and current state of the assessment of the SpondyloArthritis International Society (ASAS criteria for the classification of axial and peripheral spondyloarthritis (SpA and the possible implications in the pediatric population. The ASAS criteria evolved from the idea that the earlier the recognition of patients with ankylosing spondylitis, the better the efficacy of tumor necrosis factor blockers. Strategies included the development of new concepts, definitions, and techniques for the study of clinical signs and symptoms. Of relevance, the new definition of inflammatory back pain (IBP and the introduction of sacroiliitis by magnetic resonance imaging represented the most important advance in the early identification of AS in the “pre-radiographic stage” of the disease. AS is considered in this paper as a disease continuum with symptoms depending on age at onset. The application of those specific strategies in children and adolescents with SpA seems limited because the most important manifestation in the early stage of disease is not IBP, but peripheral arthritis and enthesitis. In this instance, the logical approach to juvenile onset SpA according to ASAS criteria should not be through the axial criteria but rather the peripheral set of criteria.

  15. Axial myopathy

    DEFF Research Database (Denmark)

    Witting, Nanna; Andersen, Linda K; Vissing, John

    2016-01-01

    musculature involvement in the majority of myopathies in which paraspinal musculature was examined. Even in diseases named after a certain pattern of non-axial muscle affection, such as facioscapulohumeral and limb girdle muscular dystrophies, affection of the axial musculature was often severe and early...

  16. A new concept of auxiliary fuel injection through tuyeres in blast furnaces developed by numerical simulations

    Directory of Open Access Journals (Sweden)

    Bruno Orlando de Almeida Santos

    2014-04-01

    Full Text Available The Injection of powdered materials in blast furnaces is a great option for reducing costs, increasing productivity and satisfy the environmental norms. Thus, this paper presents a study on the use of a flame stabilization system with rotation, designed to promote greater coal injection in the combustion zone, reducing losses and increasing the efficiency of the equipment. A physical model was used to evaluate scattering of pulverized fuel and is compared with numerical results in the same scale. In the second step, a combustion model was added to the numerical simulation, using dimensions of a real blast furnace. Fields like temperature, velocity and behavior of chemical reactions were analyzed. The results showed that double lances promote better particle injection when compared with simple lance for reduced material injection. The new injection system proposed, with swirl numbers of 0.12 and 0.24, promoted a better injection of both reduced material and temperature in the raceway zone. The swirl 0.24 showed superior performance when compared to other injection systems.

  17. New concept of combustion technology in small DI diesel engines. 4th Report. Effects of fuel injection rates on MK combustion; Kogata chokufun diesel kikan no shinnensho concept. 4. Funsharitsu no MK nensho eno eikyo

    Energy Technology Data Exchange (ETDEWEB)

    Kimura, S.; Matsui, Y.; Kamihara, T. [Nissan Motor Co. Ltd., Tokyo (Japan)

    1997-10-01

    A previous paper showed that EGR cooling and a low compression ratio which prolongs the ignition delay can expand the area of the new combustion concept. Experimental investigations were conducted in this research to examine the effects of the fuel injection rates, the injection pressure and the injection duration, on the exhaust emissions of an engine incorporating the MK concept The results showed that a higher injection pressure was effective in reducing NOx and particulate matter (PM) under MK combustion conditions. 10 refs., 9 figs., 1 tab.

  18. Novel multi-chromophor light absorber concepts for DSSCs for efficient electron injection

    Energy Technology Data Exchange (ETDEWEB)

    Schuetz, Robert; Strothkaemper, Christian; Bartelt, Andreas; Hannappel, Thomas; Eichberger, Rainer [Helmholtz-Zentrum Berlin fuer Materialien und Energie, Hahn-Meitner-Platz 1, 14109 Berlin (Germany); Fasting, Carlo [Institut fuer Organische Chemie, Freie Universitaet Berlin, Takustrasse 3, 14195 Berlin (Germany); Thomas, Inara [Helmholtz-Zentrum Berlin fuer Materialien und Energie, Hahn-Meitner-Platz 1, 14109 Berlin (Germany); Institut fuer Organische Chemie, Freie Universitaet Berlin, Takustrasse 3, 14195 Berlin (Germany)

    2011-07-01

    Dye sensitized solar cells (DSSCs) operate by injecting electrons from the excited state of a light-harvesting dye into the continuum of conduction band states of a wide bandgap semiconductor. The light harvesting efficiency of pure organic dyes is limited by a narrow spectral electronic transition. A beneficial broad ground state absorption in the VIS region can be achieved by applying a single molecular dye system with multiple chromophors involving a Foerster resonance energy transfer (FRET) mechanism for an efficient electron injection. A model donor acceptor dye system capable for FRET chemically linked to colloidal TiO{sub 2} and ZnO nanorod surfaces was investigated in UHV environment. We used VIS/NIR femtosecond transient absorption spectroscopy and optical pump terahertz probe spectroscopy to study the charge injection dynamics of the antenna system. Different chromophors attached to a novel scaffold/anchor system connecting the organic absorber unit to the metal oxide semiconductor were probed.

  19. The concept of "compartment allergy": prilocaine injected into different skin layers

    Directory of Open Access Journals (Sweden)

    Wobser Marion

    2011-04-01

    Full Text Available Abstract We herein present a patient with delayed-type allergic hypersensitivity against prilocaine leading to spreading eczematous dermatitis after subcutaneous injections for local anesthesia with prilocaine. Prilocaine allergy was proven by positive skin testing and subcutaneous provocation, whereas the evaluation of other local anesthetics - among them lidocaine, articaine and mepivacaine - did not exhibit any evidence for cross-reactivity. Interestingly, our patient repeatedly tolerated strictly deep subcutaneous injection of prilocaine in provocation testing while patch and superficial subcutaneous application mounted strong allergic responses. We hypothesize, that lower DC density in deeper cutaneous compartments and/or different DC subsets exhibiting distinct functional immunomodulatory properties in the various layers of the skin may confer to the observed absence of clinical reactivity against prilocaine after deep subcutaneous injection. The term compartment allergy indicates that the route of allergen administration together with the targeted immunologic environment orchestrates on the immunologic outcome: overt T-cell mediated allergy or clinical tolerance.

  20. FIRE, a novel concept of massive gas injection for disruption mitigation in ITER: Validation on Tore Supra

    Energy Technology Data Exchange (ETDEWEB)

    Saint-Laurent, F., E-mail: francois.saint-laurent@cea.fr [CEA, IRFM, F-13108 Saint-Paul-lez-Durance (France); Martin, G.; Alarcon, T.; Le Luyer, A.; Pastor, P. [CEA, IRFM, F-13108 Saint-Paul-lez-Durance (France); Putvinski, S. [ITER Organization, Route de Vinon sur Verdon, 13115 Saint-Paul-lez-Durance (France); Vincent, B.; Bucalossi, J.; Bremond, S.; Moreau, Ph.; Nardon, E.; Reux, C. [CEA, IRFM, F-13108 Saint-Paul-lez-Durance (France)

    2014-12-15

    Highlights: • Bursting Disc Cartridge Injector has been tested on Tore Supra. • Very high particle flux can be injected for disruption mitigation. • Direct (ballistic) penetration of gas jet into hot plasma is observed. • Radial penetration of gas jet stops at q = 2 surface and turns to poloidal propagation. • This prototype demonstrates the proof of principle of such a design. - Abstract: Disruptions in large size tokamak like ITER must be mitigated to reduce detrimental effects on the device. Massive impurity injection prior to disruption is a promising mitigation technique. Many injector designs have already been tested on nowadays tokamaks. A novel concept of injector has been designed and tested on Tore Supra. It is based on the use of high pressure cartridges sealed with a bursting disc. For firing, an electric arc is generated inside the cartridge close to the rupture disc. This initiates a shock wave which breaks the disc. Tests show that the opening is achieved in less than 400 μs. A detailed modeling of the fast injector operation is presented. One result is that the gas is expelled in about 2 ms and an outflow rate as large as 4.2 × 10{sup 25} atoms/s can be achieved at the nozzle exit (1 cm diameter). Massive neon gas injections have be performed on stable plasma to validate the concept. The gas penetration into the plasma prior to disruption is followed by a fast camera. Comparison with a ferromagnetic-valve based injector was also carried out. It is found that the velocity of the cold front penetration into the hot plasma is larger using this new injector.

  1. An Idealized, Single Radial Swirler, Lean-Direct-Injection (LDI) Concept Meshing Script

    Science.gov (United States)

    Iannetti, Anthony C.; Thompson, Daniel

    2008-01-01

    To easily study combustor design parameters using computational fluid dynamics codes (CFD), a Gridgen Glyph-based macro (based on the Tcl scripting language) dubbed BladeMaker has been developed for the meshing of an idealized, single radial swirler, lean-direct-injection (LDI) combustor. BladeMaker is capable of taking in a number of parameters, such as blade width, blade tilt with respect to the perpendicular, swirler cup radius, and grid densities, and producing a three-dimensional meshed radial swirler with a can-annular (canned) combustor. This complex script produces a data format suitable for but not specific to the National Combustion Code (NCC), a state-of-the-art CFD code developed for reacting flow processes.

  2. Novel Concepts for Optimization of the CERN Large Hadron Collider Injection Lines.

    CERN Document Server

    Fuchsberger, Kajetan; Wenninger, J

    2011-01-01

    The Large Hadron Collider (LHC) is presently the particle accelerator with the highest center of mass energy in the world and is for that reason the most promising instrument for particle physics discoveries in the near future. The transfer lines TI2 and TI8 which transfer the beam from the last pre-accelerator, the Super Proton Synchrotron (SPS), to the LHC are with a total length of about 6 km the longest ones in the world, which makes it necessary to do optics matching with high precision. Tests between 2004 and 2008 revealed several, previousely unpredicted, effects in these lines: An assymetry in betatron phase between the two transverse planes, a dispersion mismatch at the injection point from the transfer lines to the LHC and unexpectedly strong transverse coupling at the same location. In this thesis, we introduce the methods and tools that we developed to investigate these discrepancies. We describe the analysis of the available data, measurements of the transfer line optics and the calculation of op...

  3. Analysis of thin-walled cylindrical composite shell structures subject to axial and bending loads: Concept development, analytical modeling and experimental verification

    Science.gov (United States)

    Mahadev, Sthanu

    Continued research and development efforts devoted in recent years have generated novel avenues towards the advancement of efficient and effective, slender laminated fiber-reinforced composite members. Numerous studies have focused on the modeling and response characterization of composite structures with particular relevance to thin-walled cylindrical composite shells. This class of shell configurations is being actively explored to fully determine their mechanical efficacy as primary aerospace structural members. The proposed research is targeted towards formulating a composite shell theory based prognosis methodology that entails an elaborate analysis and investigation of thin-walled cylindrical shell type laminated composite configurations that are highly desirable in increasing number of mechanical and aerospace applications. The prime motivation to adopt this theory arises from its superior ability to generate simple yet viable closed-form analytical solution procedure to numerous geometrically intense, inherent curvature possessing composite structures. This analytical evaluative routine offers to acquire a first-hand insight on the primary mechanical characteristics that essentially govern the behavior of slender composite shells under typical static loading conditions. Current work exposes the robustness of this mathematical framework via demonstrating its potential towards the prediction of structural properties such as axial stiffness and bending stiffness respectively. Longitudinal ply-stress computations are investigated upon deriving the global stiffness matrix model for composite cylindrical tubes with circular cross-sections. Additionally, this work employs a finite element based numerical technique to substantiate the analytical results reported for cylindrically shaped circular composite tubes. Furthermore, this concept development is extended to the study of thin-walled, open cross-sectioned, curved laminated shells that are geometrically

  4. Comparison of aerodynamic characteristics between a novel highly loaded injected blade with curvature induced pressure-recovery concept and one with conventional design

    Directory of Open Access Journals (Sweden)

    Zhiyuan CAO

    2017-06-01

    Full Text Available This paper introduces a novel design method of highly loaded compressor blades with air injection. CFD methods were firstly validated with existing data and then used to develop and investigate the new method based on a compressor cascade. A compressor blade is designed with a curvature induced pressure-recovery concept. A rapid drop of the local curvature on the blade suction surface results in a sudden increase in the local pressure, which is referred to as a curvature induced ‘Shock’. An injection slot downstream from the ‘Shock’ is used to prevent ‘Shock’ induced separation, thus reducing the loss. As a result, the compressor blade achieves high loading with acceptable loss. First, the design concept based on a 2D compressor blade profile is introduced. Then, a 3D cascade model is investigated with uniform air injection along the span. The effects of the incidence are also investigated on emphasis in the current study. The mid-span flow field of the 3D injected cascade shows excellent agreement with the 2D designed flow field. For the highly loaded cascade without injection, the flow separates immediately downstream from the ‘Shock’; the initial location of separation shows little change in a large incidence range. Thus air injection with the same injection configuration effectively removes the flow separation downstream from the curvature induced ‘Shock’ and reduces the size of the separation zone at different incidences. Near the endwall, the flow within the incoming passage vortex mixes with the injected flow. As a result, the size of the passage vortex reduces significantly downstream from the injection slot. After air injection, the loss coefficient along spanwise reduces significantly and the flow turning angle increases.

  5. Mechanism Analysis of Stability Improvement with Tip Injection in a Transonic Axial-Flow Compressor Rotor%跨音轴流压气机转子叶尖喷气扩稳机理分析

    Institute of Scientific and Technical Information of China (English)

    吴艳辉; 田江涛; 李清鹏; 张卓勋; 楚武利

    2011-01-01

    Multichannel,full three-dimensional,steady/unsteady numerical simulation with tip injection was carried out for NASA Rotor 35.The predicted overall performance of solid casing agreed very well with the experimental data.Predicted result showed that the stall margin could be improved by 21.4%when the jet amount was equal to 3.6%of choke mass flow of the rotor. The steady calculations showed that nearly 10%outerspan of flow annulus was influenced by tip injection.The high axial momentum introduced by injection decreased the flow incidence angle and diffusion factor,thus reducing near-tip blade loading,and accordingly the blockage region arising from the interaction between passage shock and tip leakage vortex.Unsteady simulation showed that stall margin improvement attribute to two aspects:one is reducing the loading on a certain blade,and the other is reinjection axial momentum into the low energy region formed by the interaction between shock/leakage vortex.The latter improved the passage flow to larger extent than that of the former.The higher jet frequency can make the tip injection restrain further development of low-speed area in each passage so as to achieve the stability improvement of compressor.%对跨音压气机Rotor35进行了多通道全三维定常/非定常叶顶喷气数值模拟。数值计算所获得实壁机匣总性能与试验结果符合良好。计算表明使用3.6%转子堵塞流量的叶顶喷气量可以获得21.4%的扩稳效果。定常计算结果显示叶顶喷气重点影响0.9叶展以上区域,使得该区域进气攻角和扩散因子减小,从而降低叶顶载荷,减小了由激波和泄漏涡相互作用形成的通道堵塞。非定常计算结果显示,叶尖喷气的扩稳效果来自两方面:一是对某一叶片叶顶的卸载作用;二是对激波/泄漏涡干扰形成的低能区重新注入轴向动量。后者对通道流通的改善作用大于前者。

  6. Implications of the center of rotation concept for the reconstruction of anterior column lordosis and axial preloads in spinal deformity surgery.

    Science.gov (United States)

    Koller, Heiko; Mayer, Michael; Zenner, Juliane; Resch, Herbert; Niederberger, Alfred; Fierlbeck, Johann; Hitzl, Wolfgang; Acosta, Frank L

    2012-07-01

    In thoracolumbar deformity surgery, anterior-only approaches are used for reconstruction of anterior column failures. It is generally advised that vertebral body replacements (VBRs) should be preloaded by compression. However, little is known regarding the impact of different techniques for generation of preloads and which surgical principle is best for restoration of lordosis. Therefore, the authors analyzed the effect of different surgical techniques to restore spinal alignment and lordosis as well as the ability to generate axial preloads on VBRs in anterior column reconstructions. The authors performed a laboratory study using 7 fresh-frozen specimens (from T-3 to S-1) to assess the ability for lordosis reconstruction of 5 techniques and their potential for increasing preloads on a modified distractable VBR in a 1-level thoracolumbar corpectomy. The testing protocol was as follows: 1) Radiographs of specimens were obtained. 2) A 1-level corpectomy was performed. 3) In alternating order, lordosis was applied using 1 of the 5 techniques. Then, preloads during insertion and after relaxation using the modified distractable VBR were assessed using a miniature load-cell incorporated in the modified distractable VBR. The modified distractable VBR was inserted into the corpectomy defect after lordosis was applied using 1) a lamina spreader; 2) the modified distractable VBR only; 3) the ArcoFix System (an angular stable plate system enabling in situ reduction); 4) a lordosizer (a customized instrument enabling reduction while replicating the intervertebral center of rotation [COR] according to the COR method); and 5) a lordosizer and top-loading screws ([LZ+TLS], distraction with the lordosizer applied on a 5.5-mm rod linked to 2 top-loading pedicle screws inserted laterally into the vertebra). Changes in the regional kyphosis angle were assessed radiographically using the Cobb method. The bone mineral density of specimens was 0.72 ± 22.6 g/cm(2). The maximum regional

  7. A concept for energy harvesting from quasi-static structural deformations through axially loaded bilaterally constrained columns with multiple bifurcation points

    Science.gov (United States)

    Lajnef, N.; Burgueño, R.; Borchani, W.; Sun, Y.

    2014-05-01

    A major obstacle limiting the development of deployable sensing and actuation solutions is the scarcity of power. Converted energy from ambient loading using piezoelectric scavengers is a possible solution. Most of the previously developed research focused on vibration-based piezoelectric harvesters which are typically characterized by a response with a narrow natural frequency range. Several techniques were used to improve their effectiveness. These methods focus only on the transducer’s properties and configurations, but do little to improve the stimuli from the source. In contrast, this work proposes to focus on the input deformations generated within the structure, and the induction of an amplified amplitude and up-converted frequency toward the harvesters’ natural spectrum. This paper introduces the concept of using mechanically-equivalent energy converters and frequency modulators that can transform low-amplitude and low-rate service deformations into an amplified vibration input to the piezoelectric transducer. The introduced concept allows energy conversion within the unexplored quasi-static frequency range (≪1 Hz). The post-buckling behavior of bilaterally constrained columns is used as the mechanism for frequency up-conversion. A bimorph cantilever polyvinylidene fluoride (PVDF) piezoelectric beam is used for energy conversion. Experimental prototypes were built and tested to validate the introduced concept and the levels of extractable power were evaluated for different cases under varying input frequencies. Finally, finite element simulations are reported to provide insight into the scalability and performance of the developed concept.

  8. Light axial vector mesons

    CERN Document Server

    Chen, Kan; Liu, Xiang; Matsuki, Takayuki

    2015-01-01

    Inspired by the abundant experimental observation of axial vector states, we study whether the observed axial vector states can be categorized into the conventional axial vector meson family. In this paper we carry out analysis based on the mass spectra and two-body Okubo-Zweig-Iizuka-allowed decays. Besides testing the possible axial vector meson assignments, we also predict abundant information for their decays and the properties of some missing axial vector mesons, which are valuable to further experimental exploration of the observed and predicted axial vector mesons.

  9. Effects of Swirl Bubble Injection on Mass Transfer and Hydrodynamics for Bubbly Flow Reactors: A Concept Paper

    Directory of Open Access Journals (Sweden)

    Farooqi Ahmad Salam

    2017-01-01

    Full Text Available Bubble flow reactors (BFR are commonly used for various industrial processes in the field of oil and gas production, pharmaceutical industries, biochemical and environmental engineering etc. The operation and performance of these reactors rely heavily on a range of hydrodynamic parameters; prominent among them are geometric configurations including gas injection geometry, operating conditions, mass transfer etc. A huge body of literature is available to describe the optimum design and performance of bubbly flow reactors with conventional bubble injection. Attempts were made to modify gas injection for improved efficiency of BFR’s. However, here instead of modifying the geometry of the gas injection, an attempt has been made to generate swirl bubbles for gaining larger mass transfer between gas and liquid. Here an exceptionally well thought strategies have been used in our numerical simulations towards the design of swirl injection mechanism, whose paramount aspect is to inhibit the rotary liquid motion but facilitates the swirl movement for bubbles in nearly stationary liquid. Our comprehension here is that the swirl motion can strongly affect the performance of bubbly reactor by identifying the changes in hydrodynamic parameters as compared to the conventional bubbly flows. In order to achieve this bubbly flow, an experimental setup has been designed as well as computational fluid dynamic (CFD code was used with to highlight a provision of swirl bubble injection by rotating the sparger plate.

  10. A Single-Vector, Single-Injection Trivalent Filovirus Vaccine: Proof of Concept Study in Outbred Guinea Pigs.

    Science.gov (United States)

    Mire, Chad E; Geisbert, Joan B; Versteeg, Krista M; Mamaeva, Natalia; Agans, Krystle N; Geisbert, Thomas W; Connor, John H

    2015-10-01

    The filoviruses, Marburg marburgvirus (MARV), Zaire ebolavirus (ZEBOV), and Sudan ebolavirus (SEBOV), cause severe and often fatal hemorrhagic fever in humans and nonhuman primates (NHPs). Monovalent recombinant vesicular stomatitis virus (rVSV)-based vaccine vectors, which encode a filovirus glycoprotein (GP) in place of the VSV glycoprotein, have shown 100% efficacy against homologous filovirus challenge in rodent and NHP studies. Here, we examined the utility of a single-vector, single-injection trivalent rVSV vector expressing MARV, ZEBOV, and SEBOV GPs to protect against MARV-, ZEBOV-, and SEBOV-induced disease in outbred Hartley guinea pigs where we observed protection from effects of all 3 filoviruses.

  11. Thermionic plasma injection for the Lockheed Martin T4 Compact Fusion Reactor experiment

    Science.gov (United States)

    Heinrich, Jonathon

    2015-11-01

    Lockheed Martin's Compact Fusion Reactor (CFR) concept relies on diamagnetic confinement in a magnetically encapsulated linear ring cusp geometry. Plasma injection into cusp field configurations requires careful deliberation. Previous work has shown that axial injection via a plasma gun is capable of achieving high-beta conditions in cusp configurations. We present a pulsed, high power thermionic plasma source and the associated magnetic field topology for plasma injection into the caulked-cusp magnetic field. The resulting plasma fueling and cross-field diffusion is discussed.

  12. Amphiregulin Antibody and Reduction of Axial Elongation in Experimental Myopia

    Directory of Open Access Journals (Sweden)

    Wen Jun Jiang

    2017-03-01

    Full Text Available To examine the mechanism of ocular axial elongation in myopia, guinea pigs (age: 2–3 weeks which either underwent unilateral or bilateral lens-induced myopization (group 1 or which were primarily myopic at baseline (group 2 received unilateral intraocular injections of amphiregulin antibody (doses: 5, 10, or 15 μg three times in intervals of 9 days. A third group of emmetropic guinea pigs got intraocular unilateral injections of amphiregulin (doses: 0.25, 0.50 or 1.00 ng, respectively. In each group, the contralateral eyes received intraocular injections of Ringer's solution. In intra-animal inter-eye comparison and intra-eye follow-up comparison in groups 1 and 2, the study eyes as compared to the contralateral eyes showed a dose-dependent reduction in axial elongation. In group 3, study eyes and control eyes did not differ significantly in axial elongation. Immunohistochemistry revealed amphiregulin labelling at the retinal pigment epithelium in eyes with lens-induced myopization and Ringer's solution injection, but not in eyes with amphiregulin antibody injection. Intraocular injections of amphiregulin-antibody led to a reduction of lens-induced axial myopic elongation and of the physiological eye enlargement in young guinea pigs. In contrast, intraocularly injected amphiregulin in a dose of ≤1 ng did not show a significant effect. Amphiregulin may be one of several essential molecular factors for axial elongation.

  13. BWR AXIAL PROFILE

    Energy Technology Data Exchange (ETDEWEB)

    J. Huffer

    2004-09-28

    The purpose of this calculation is to develop axial profiles for estimating the axial variation in burnup of a boiling water reactor (BWR) assembly spent nuclear fuel (SNF) given the average burnup of an assembly. A discharged fuel assembly typically exhibits higher burnup in the center and lower burnup at the ends of the assembly. Criticality safety analyses taking credit for SNF burnup must account for axially varying burnup relative to calculations based on uniformly distributed assembly average burnup due to the under-burned tips. Thus, accounting for axially varying burnup in criticality analyses is also referred to as accounting for the ''end effect'' reactivity. The magnitude of the reactivity change due to ''end effect'' is dependent on the initial assembly enrichment, the assembly average burnup, and the particular axial profile characterizing the burnup distribution. The set of bounding axial profiles should incorporate multiple BWR core designs and provide statistical confidence (95 percent confidence that 95 percent of the population is bound by the profile) that end nodes are conservatively represented. The profiles should also conserve the overall burnup of the fuel assembly. More background on BWR axial profiles is provided in Attachment I.

  14. Virtual reality imaging with real-time ultrasound guidance for facet joint injection: a proof of concept.

    Science.gov (United States)

    Clarke, Collin; Moore, John; Wedlake, Christopher; Lee, Donald; Ganapathy, Su; Salbalbal, Maher; Wilson, Timothy; Peters, Terry; Bainbridge, Daniel

    2010-05-01

    Facet interventions continue to be used in pain management. Computed tomographic (CT) images can be registered into a virtual world that includes images generated by an ultrasound (US) probe tracked in real time, permitting guidance of tracked needles. We acquired CT-generated 3-dimensional (3D) images of 2 models and a cadaver. Three-dimensional representations of a US probe and needle were generated. A magnetic system tracked the needle and US probe. Using the US, 3D CT images were registered to the model/cadaver. Images were fused on a single interface. Facet injections were performed in the models and cadaver with radio-opaque markers. A postprocedure CT image determined appropriate placement. The virtual reality system described demonstrates technical innovations that may lead to future advancements in the area of percutaneous interventions in the management of pain.

  15. [Management of axial spondyloarthritis].

    Science.gov (United States)

    Kiltz, U; Baraliakos, X; Braun, J

    2016-11-01

    The term spondyloarthritis (SpA) is now increasingly used to classify and diagnose patients who are characterized by inflammation in the axial skeleton and peripheral manifestations (arthritis and enthesitis). The management of SpA should be tailored according to the current manifestations of the disease, the disease activity and functional impairment. The current article focuses on diagnosis and therapy in patients with axial SpA. Diagnostic procedures are discussed in light of diagnostic utility and feasibility in daily routine care. Cornerstones of treatment in patients with axial SpA are a combination of regular exercise and pharmacological treatment options aiming at anti-inflammatory strategies.

  16. Axial Halbach Magnetic Bearings

    Science.gov (United States)

    Eichenberg, Dennis J.; Gallo, Christopher A.; Thompson, William K.

    2008-01-01

    Axial Halbach magnetic bearings have been investigated as part of an effort to develop increasingly reliable noncontact bearings for future high-speed rotary machines that may be used in such applications as aircraft, industrial, and land-vehicle power systems and in some medical and scientific instrumentation systems. Axial Halbach magnetic bearings are passive in the sense that unlike most other magnetic bearings that have been developed in recent years, they effect stable magnetic levitation without need for complex active control.

  17. Aerodynamics and combustion of axial swirlers

    Science.gov (United States)

    Fu, Yongqiang

    A multipoint lean direct injection (LDI) concept was introduced recently in non-premixed combustion to obtain both low NOx emissions and good combustion stability. In this concept, a key feature is the injection of finely atomized fuel into the high-swirling airflow at the combustor dome that provides a homogenous, lean fuel-air mixture. In order to achieve the fine atomization and mixing of the fuel and air quickly and uniformly, a good swirler design should be studied. The focus of this dissertation is to investigate the aerodynamics and combustion of the swirling flow field in a multipoint Lean Direct Injector combustor. A helical axial-vaned swirler with a short internal convergent-divergent venturi was used. Swirlers with various vane angles and fuel nozzle insertion lengths have been designed. Three non-dimensional parameter effects on non-reacting, swirling flow field were studied: swirler number, confinement ratio and Reynolds number. Spray and combustion characteristics on the single swirler were studied to understand the mechanism of fuel-air mixing in this special configuration. Multi-swirler interactions were studied by measuring the confined flow field of a multipoint swirler array with different configurations. Two different swirler arrangements were investigated experimentally, which include a co-swirling array and a counter-swirling array. In order to increase the range of stability of multipoint LDI combustors, an improved design were also conducted. The results show that the degree of swirl and the level of confinement have a clear impact on the mean and turbulent flow fields. The swirling flow fields may also change significantly with the addition of a variety of simulated fuel nozzle insertion lengths. The swirler with short insertion has the stronger swirling flow as compared with the long insertion swirler. Reynolds numbers, with range of current study, will not alter mean and turbulent properties of generated flows. The reaction of the spray

  18. «FLARES» IN AXIAL SPONDYLOARTHRITIS

    Directory of Open Access Journals (Sweden)

    Sh. F. Erdes

    2016-01-01

    Full Text Available The clear definition of the concept of «flare in axial spondyloarthritis» is of paramount importance for clinical trials and routine practice in particular. It will be able to unify the characteristics of outcomes over a particular period of time on the one hand and to standardize therapeutic approaches on the other. On 4 February 2016, the journal Annals of Rheumatic Diseases published the on-line paper «Preliminary definitions of 'flare' in axial spondyloarthritis, based on pain, BASDAI and ASDAS-CRP: an ASAS initiative» by L. Gossec et al., which was devoted to this topic.

  19. Altered Axial Skeletal Development

    Science.gov (United States)

    The axial skeleton is routinely examined in standard developmental toxicity bioassays and has proven to be sensitive to a wide variety of chemical agents. Dysmorphogenesis in the skull, vertebral column and ribs has been described in both human populations and in laboratory anima...

  20. Surface nanoscale axial photonics

    CERN Document Server

    Sumetsky, M

    2011-01-01

    Dense photonic integration promises to revolutionize optical computing and communications. However, efforts towards this goal face unacceptable attenuation of light caused by surface roughness in microscopic devices. Here we address this problem by introducing Surface Nanoscale Axial Photonics (SNAP). The SNAP platform is based on whispering gallery modes circulating around the optical fiber surface and undergoing slow axial propagation readily described by the one-dimensional Schr\\"odinger equation. These modes can be steered with dramatically small nanoscale variation of the fiber radius, which is quite simple to introduce in practice. The extremely low loss of SNAP devices is achieved due to the fantastically low surface roughness inherent in a drawn fiber surface. In excellent agreement with the developed theory, we experimentally demonstrate localization of light in quantum wells, halting light by a point source, tunneling through potential barriers, dark states, etc. This demonstration, prototyping basi...

  1. Critical Axial Load

    Directory of Open Access Journals (Sweden)

    Walt Wells

    2008-01-01

    Full Text Available Our objective in this paper is to solve a second order differential equation for a long, simply supported column member subjected to a lateral axial load using Heun's numerical method. We will use the solution to find the critical load at which the column member will fail due to buckling. We will calculate this load using Euler's derived analytical approach for an exact solution, as well as Euler's Numerical Method. We will then compare the three calculated values to see how much they deviate from one another. During the critical load calculation, it will be necessary to calculate the moment of inertia for the column member.

  2. Might axial myofascial properties and biomechanical mechanisms be relevant to ankylosing spondylitis and axial spondyloarthritis?

    Science.gov (United States)

    Masi, Alfonse T

    2014-01-01

    Ankylosing spondylitis and axial spondyloarthropathy have characteristic age- and sex-specific onset patterns, typical entheseal lesions, and marked heritability, but the integrative mechanisms causing the pathophysiological and structural alterations remain largely undefined. Myofascial tissues are integrated in the body into webs and networks which permit transmission of passive and active tensional forces that provide stabilizing support and help to control movements. Axial myofascial hypertonicity was hypothesized as a potential excessive polymorphic trait which could contribute to chronic biomechanical overloading and exaggerated stresses at entheseal sites. Such a mechanism may help to integrate many of the characteristic host, pathological, and structural features of ankylosing spondylitis and axial spondyloarthritis. Biomechanical stress and strain were recently documented to correlate with peripheral entheseal inflammation and new bone formation in a murine model of spondyloarthritis. Ankylosing spondylitis has traditionally been classified by the modified New York criteria, which require the presence of definite radiographic sacroiliac joint lesions. New classification criteria for axial spondyloarthritis now include patients who do not fulfill the modified New York criteria. The male-to-female sex ratios clearly differed between the two patient categories - 2:1 or 3:1 in ankylosing spondylitis and 1:1 in non-radiographic axial spondyloarthritis - and this suggests a spectral concept of disease and, among females, milder structural alterations. Magnetic resonance imaging of active and chronic lesions in ankylosing spondylitis and axial spondyloarthritis reveals complex patterns, usually interpreted as inflammatory reactions, but shows similarities to acute degenerative disc disease, which attributed to edema formation following mechanical stresses and micro-damage. A basic question is whether mechanically induced microinjury and immunologically mediated

  3. Build Axial Gradient Field by Using Axial Magnetized Permanent Rings

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Axial magnetic field produced by an axial magnetized permanent ring was studied. For two permanent rings, if they are magnetized in the same directions, a nearly uniform axial field can be produced. If they are magnetized in opposite direction,an axial gradient magnetic field can be generated, with the field range changing from -B0 to B0. A permanent magnet with a high axial gradient field was fabricated, the measured results agree with the PANDIRA calculation very well. For wider usage,it is desirable for the field gradient to be changed. Some methods to produce the variable gradient field are presented. These kinds of axial gradient magnetic field can also be used as a beam focusing for linear accelerator if the periodic field can be produced along the beam trajectory. The axial magnetic field is something like a solenoid, large stray field will leak to the outside environment if no method is taken to control them. In this paper, one method is illustrated to shield off the outside leakage field.

  4. Bessel beam CARS of axially structured samples

    Science.gov (United States)

    Heuke, Sandro; Zheng, Juanjuan; Akimov, Denis; Heintzmann, Rainer; Schmitt, Michael; Popp, Jürgen

    2015-01-01

    We report about a Bessel beam CARS approach for axial profiling of multi-layer structures. This study presents an experimental implementation for the generation of CARS by Bessel beam excitation using only passive optical elements. Furthermore, an analytical expression is provided describing the generated anti-Stokes field by a homogeneous sample. Based on the concept of coherent transfer functions, the underling resolving power of axially structured geometries is investigated. It is found that through the non-linearity of the CARS process in combination with the folded illumination geometry continuous phase-matching is achieved starting from homogeneous samples up to spatial sample frequencies at twice of the pumping electric field wave. The experimental and analytical findings are modeled by the implementation of the Debye Integral and scalar Green function approach. Finally, the goal of reconstructing an axially layered sample is demonstrated on the basis of the numerically simulated modulus and phase of the anti-Stokes far-field radiation pattern. PMID:26046671

  5. Dissipative Axial Inflation

    CERN Document Server

    Notari, Alessio

    2016-01-01

    We analyze in detail the background cosmological evolution of a scalar field coupled to a massless abelian gauge field through an axial term $\\frac{\\phi}{f_\\gamma} F \\tilde{F}$, such as in the case of an axion. Gauge fields in this case are known to experience tachyonic growth and therefore can backreact on the background as an effective dissipation into radiation energy density $\\rho_R$, which which can lead to inflation without the need of a flat potential. We analyze the system, for momenta $k$ smaller than the cutoff $f_\\gamma$, including numerically the backreaction. We consider the evolution from a given static initial condition and explicitly show that, if $f_\\gamma$ is smaller than the field excursion $\\phi_0$ by about a factor of at least ${\\cal O} (20)$, there is a friction effect which turns on before that the field can fall down and which can then lead to a very long stage of inflation with a generic potential. In addition we find superimposed oscillations, which would get imprinted on any kind of...

  6. Medroxyprogesterone Injection

    Science.gov (United States)

    Medroxyprogesterone intramuscular (into a muscle) injection and medroxyprogesterone subcutaneous (under the skin) injection are used to prevent pregnancy. Medroxyprogesterone subcutaneous injection is also used to treat endometriosis (a condition in which ...

  7. Pentamidine Injection

    Science.gov (United States)

    Pentamidine injection is used to treat pneumonia caused by a fungus called Pneumocystis carinii. It is in ... Pentamidine injection comes as powder to be mixed with liquid to be injected intramuscularly (into a muscle) ...

  8. Study of axial magnetic effect

    Energy Technology Data Exchange (ETDEWEB)

    Braguta, Victor [IHEP, Protvino, Moscow region, 142284 Russia ITEP, B. Cheremushkinskaya street 25, Moscow, 117218 (Russian Federation); School of Biomedicine, Far Eastern Federal University, Ajax 10 Building 25, Russian island, Vladivostok, 690922 (Russian Federation); Chernodub, M. N. [CNRS, Laboratoire de Mathématiques et Physique Théorique, Université François-Rabelais Tours, Fédération Denis Poisson, Parc de Grandmont, 37200 Tours, France Department of Physics and Astronomy, University of Gent, Krijgslaan 281, S9, B-9000 Gent (Belgium); School of Biomedicine, Far Eastern Federal University, Ajax 10 Building 25, Russian island, Vladivostok, 690922 (Russian Federation); Goy, V. A. [School of Natural Sciences, Far Eastern Federal University, Sukhanova street 8, Vladivostok, 690950 (Russian Federation); Landsteiner, K. [Instituto de Física Teórica UAM/CSIC, C/ Nicolás Cabrera 13-15, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid (Spain); Molochkov, A. V. [School of Biomedicine, Far Eastern Federal University, Ajax 10 Building 25, Russian island, Vladivostok, 690922 (Russian Federation); Ulybyshev, M. [ITEP, B. Cheremushkinskaya street 25, Moscow, 117218 Russia Institute for Theoretical Problems of Microphysics, Moscow State University, Moscow, 119899 (Russian Federation)

    2016-01-22

    The Axial Magnetic Effect manifests itself as an equilibrium energy flow of massless fermions induced by the axial (chiral) magnetic field. Here we study the Axial Magnetic Effect in the quenched SU(2) lattice gauge theory with massless overlap fermions at finite temperature. We numerically observe that in the low-temperature hadron phase the effect is absent due to the quark confinement. In the high-temperature deconfinement phase the energy flow is an increasing function of the temperature which reaches the predicted asymptotic T{sup 2} behavior at high temperatures. We find, however, that energy flow is about one order of magnitude lower compared to a theoretical prediction.

  9. Radial lean direct injection burner

    Science.gov (United States)

    Khan, Abdul Rafey; Kraemer, Gilbert Otto; Stevenson, Christian Xavier

    2012-09-04

    A burner for use in a gas turbine engine includes a burner tube having an inlet end and an outlet end; a plurality of air passages extending axially in the burner tube configured to convey air flows from the inlet end to the outlet end; a plurality of fuel passages extending axially along the burner tube and spaced around the plurality of air passage configured to convey fuel from the inlet end to the outlet end; and a radial air swirler provided at the outlet end configured to direct the air flows radially toward the outlet end and impart swirl to the air flows. The radial air swirler includes a plurality of vanes to direct and swirl the air flows and an end plate. The end plate includes a plurality of fuel injection holes to inject the fuel radially into the swirling air flows. A method of mixing air and fuel in a burner of a gas turbine is also provided. The burner includes a burner tube including an inlet end, an outlet end, a plurality of axial air passages, and a plurality of axial fuel passages. The method includes introducing an air flow into the air passages at the inlet end; introducing a fuel into fuel passages; swirling the air flow at the outlet end; and radially injecting the fuel into the swirling air flow.

  10. Dissipative axial inflation

    Science.gov (United States)

    Notari, Alessio; Tywoniuk, Konrad

    2016-12-01

    We analyze in detail the background cosmological evolution of a scalar field coupled to a massless abelian gauge field through an axial term phi/fγ F ~F, such as in the case of an axion. Gauge fields in this case are known to experience tachyonic growth and therefore can backreact on the background as an effective dissipation into radiation energy density ρR, which can lead to inflation without the need of a flat potential. We analyze the system, for momenta k smaller than the cutoff fγ, including the backreaction numerically. We consider the evolution from a given static initial condition and explicitly show that, if fγ is smaller than the field excursion phi0 by about a factor of at least Script O (20), there is a friction effect which turns on before the field can fall down and which can then lead to a very long stage of inflation with a generic potential. In addition we find superimposed oscillations, which would get imprinted on any kind of perturbations, scalars and tensors. Such oscillations have a period of 4-5 efolds and an amplitude which is typically less than a few percent and decreases linearly with fγ. We also stress that the curvature perturbation on uniform density slices should be sensitive to slow-roll parameters related to ρR rather than dot phi2/2 and we discuss the existence of friction terms acting on the perturbations, although we postpone a calculation of the power spectrum and of non-gaussianity to future work and we simply define and compute suitable slow roll parameters. Finally we stress that this scenario may be realized in the axion case, if the coupling 1/fγ to U(1) (photons) is much larger than the coupling 1/fG to non-abelian gauge fields (gluons), since the latter sets the range of the potential and therefore the maximal allowed phi0~ fG.

  11. Dynamic axial stabilization of counterpropagating beam-traps with feedback control

    DEFF Research Database (Denmark)

    Tauro, Sandeep; Bañas, Andrew Rafael; Palima, Darwin

    2010-01-01

    Optical trapping in a counter-propagating (CP) beam-geometry provides unique advantages in terms of working distance, aberration requirements and intensity hotspots. However, its axial performance is governed by the wave propagation of the opposing beams, which can limit the practical geometries....... Here we propose a dynamic method for controlling axial forces to overcome this constraint. The technique uses computervision object tracking of the axial position, in conjunction with softwarebased feedback, for dynamically stabilizing the axial forces. We present proof-of-concept experiments showing...

  12. New concepts for exhaust gas turbo charging of a four-cylinder direct injection Otto engine; Neue Konzepte zur Abgasturboaufladung eines direkteinspritzenden Vierzylinder-Ottomotors

    Energy Technology Data Exchange (ETDEWEB)

    Ross, Tilo

    2008-07-01

    This work is supposed to be understood as a contribution to developing a new generation of Otto engines, which meet the increasing ecological and economical demands. The charge concept has a key position in this development. Its design in particular at the four cylinder engine that dominates the market and whose charge changes are very specific, proves to be a special challenge. Based upon known techniques new concepts are developed in this work by means of numeric simulation and experiments and then compared with each other under stationary and transient conditions. On the one hand several exhaust gas turbo chargers in form a register and a two-phase charging are combined with a variable control of the outlet valves, on the other hand the shock-back-up changing is evaluated combined with a biturbo system as well as a twin-current turbine. (orig.)

  13. Doripenem Injection

    Science.gov (United States)

    ... injection is in a class of medications called carbapenem antibiotics. It works by killing bacteria.Antibiotics such ... if you are allergic to doripenem injection; other carbapenem antibiotics such as imipenem/cilastatin (Primaxin) or meropenem ( ...

  14. Methotrexate Injection

    Science.gov (United States)

    Methotrexate injection is used alone or in combination with other medications to treat gestational trophoblastic tumors (a ... in bones) after surgery to remove the tumor. Methotrexate injection is also used to treat severe psoriasis ( ...

  15. Bendamustine Injection

    Science.gov (United States)

    Bendamustine injection is used to treat chronic lymphocytic leukemia (CLL; a type of cancer of the white ... injection. You should use birth control to prevent pregnancy in yourself or your partner during your treatment ...

  16. Caspofungin Injection

    Science.gov (United States)

    Caspofungin injection is used in adults and children 3 months of age and older to treat yeast ... people with a weakened ability to fight infection. Caspofungin injection is in a class of antifungal medications ...

  17. Temozolomide Injection

    Science.gov (United States)

    Temozolomide is used to treat certain types of brain tumors. Temozolomide is in a class of medications called alkylating ... Temozolomide injection comes as a powder to be added to fluid and injected over 90 minutes intravenously ( ...

  18. Pembrolizumab Injection

    Science.gov (United States)

    Pembrolizumab injection is used to treat melanoma (a type of skin cancer) that cannot be treated with ... who have a specific type of melanoma tumor. Pembrolizumab injection is also used to treat a certain ...

  19. Lacosamide Injection

    Science.gov (United States)

    ... injection is in a class of medications called anticonvulsants. It works by decreasing abnormal electrical activity in ... older (about 1 in 500 people) who took anticonvulsants like lacosamide injection to treat various conditions during ...

  20. Midazolam Injection

    Science.gov (United States)

    ... injection is in a class of medications called benzodiazepines. It works by slowing activity in the brain ... breast-feeding.talk to your doctor about the risks and benefits of receiving midazolam injection if you ...

  1. Doxycycline Injection

    Science.gov (United States)

    Doxycycline injection is used to treat or prevent bacterial infections, including pneumonia and other respiratory tract infections. ... certain skin, genital, intestine, and urinary system infections. Doxycycline injection may be used to treat or prevent ...

  2. Paclitaxel Injection

    Science.gov (United States)

    ... with other medications. Paclitaxel injection manufactured with polyoxyethylated castor oil is used to treat ovarian cancer (cancer that ... cancer, and lung cancer. Paclitaxel injection with polyoxyethylated castor oil is also used to treat Kaposi's sarcoma (a ...

  3. Etanercept Injection

    Science.gov (United States)

    ... will be using the prefilled syringe or automatic injection device, tell your doctor if you or the person who will be injecting the medication for you are allergic to rubber or latex.tell your doctor and pharmacist what ...

  4. Cyclosporine Injection

    Science.gov (United States)

    Cyclosporine injection is used with other medications to prevent transplant rejection (attack of the transplanted organ by ... who have received kidney, liver, and heart transplants. Cyclosporine injection should only be used to treat people ...

  5. Estrogen Injection

    Science.gov (United States)

    The estradiol cypionate and estradiol valerate forms of estrogen injection are used to treat hot flushes (hot ... should consider a different treatment. These forms of estrogen injection are also sometimes used to treat the ...

  6. Cefotaxime Injection

    Science.gov (United States)

    Cefotaxime injection is used to treat certain infections caused by bacteria including pneumonia and other lower respiratory ... skin, blood, bone, joint, and urinary tract infections. Cefotaxime injection may also be used before surgery, and ...

  7. Ustekinumab Injection

    Science.gov (United States)

    ... Do not inject into an area where the skin is tender, bruised, red, or hard or where you have scars or stretch marks.Your doctor or pharmacist will ... injection.you should know that ustekinumab injection may decrease your ability ... new or changing skin lesions, minor infections (such as open cuts or ...

  8. Ranitidine Injection

    Science.gov (United States)

    Ranitidine injection comes as a solution (liquid) to be mixed with another fluid and injected intravenously (into a vein) over 5 to 20 minutes. Ranitidine may also be injected into a muscle. It is usually given every 6 to 8 hours, but may also be given ...

  9. Injection and extraction for cyclotrons

    CERN Document Server

    Kleeven, W

    2006-01-01

    The main design goals for beam injection are explained and special problems related to a central region with internal ion source are considered. The principle of a PIG source is addressed. The issue of vertical focusing in the cyclotron centre is briefly discussed. Several examples of numerical simulations are given. Different ways of (axial) injection are briefly outlined. A proposal for a magnetostatic axial inflector is given. Different solutions for beam extraction are treated. These include the internal target, extraction by stripping, resonant extraction using a deflector and self-extraction. The different ways of creating a turn-separation are explained. The purpose of different types of extraction devices such as harmonic coils, deflectors and gradient corrector channels are outlined. Several illustrations are given in the form of photographs and drawings.

  10. Relativistic RPA in axial symmetry

    CERN Document Server

    Arteaga, D Pena; 10.1103/PhysRevC.77.034317

    2009-01-01

    Covariant density functional theory, in the framework of self-consistent Relativistic Mean Field (RMF) and Relativistic Random Phase approximation (RPA), is for the first time applied to axially deformed nuclei. The fully self-consistent RMF+RRPA equations are posed for the case of axial symmetry and non-linear energy functionals, and solved with the help of a new parallel code. Formal properties of RPA theory are studied and special care is taken in order to validate the proper decoupling of spurious modes and their influence on the physical response. Sample applications to the magnetic and electric dipole transitions in $^{20}$Ne are presented and analyzed.

  11. Axial Current and Noether Charge

    CERN Document Server

    Mahato, Prasanta

    2012-01-01

    A decade ago, a Lagrangian density has been proposed by the author where only the local symmetries of the Lorentz subgroup of (A)ds group is retained. This formalism has been found to produce some results encompassing that of standard Einstein-Hilbert formalism. In the present article, the conserved axial vector matter currents, constructed in some earlier paper, have been found to be a result of Noether's theorem. PACS: 04.20.Fy, 04.20.Cv, 11.40.-q Keywords: Torsion, Axial Current, Noether's Theorem

  12. Whole-body microvascular permeability of small molecules in man: clinical aspects, basic concepts and limitations of the single injection technique

    DEFF Research Database (Denmark)

    Henriksen, Jens Henrik Sahl

    1985-01-01

    In order to estimate whole-body permeability-surface area (PS) product, the initial slope of the plasma disappearance curve was determined after simultaneous i.v. injection of 24Na+ (mol.wt 24) and 51Cr-EDTA (mol.wt 342). Twelve subjects were studied. Plasma volume (PV) was measured...... by the indicator dilution method, and the mean transit time of tracer in plasma was calculated as the reciprocal value of the initial fractional disappearance (initial slope). Estimated whole-body PS product (= PV/t) of 24Na+ (median 2.72, range 1.51-3.80 ml/min . 100 g body weight) was significantly higher than...... of the plasma disappearance curve of a tracer, but mixing problems and flow-limited transport, as indicated by a PS ratio below that of the free diffusion coefficients, may be difficult to overcome, especially when using tracers of a low molecular weight....

  13. Concept - or no concept

    DEFF Research Database (Denmark)

    Thorsteinsson, Uffe

    1999-01-01

    Discussion about concept in industrial companies. A method for mapping of managerial concept in specific area is shown......Discussion about concept in industrial companies. A method for mapping of managerial concept in specific area is shown...

  14. Development and Testing of an Axial Halbach Magnetic Bearing

    Science.gov (United States)

    Eichenberg, Dennis J.; Gallo, Christopher A.; Thompson, William K.

    2006-01-01

    The NASA Glenn Research Center has developed and tested a revolutionary Axial Halbach Magnetic Bearing. The objective of this work is to develop a viable non-contact magnetic thrust bearing utilizing Halbach arrays for all-electric flight, and many other applications. This concept will help to reduce harmful emissions, reduce the Nation s dependence on fossil fuels and mitigate many of the concerns and limitations encountered in conventional axial bearings such as bearing wear, leaks, seals and friction loss. The Axial Halbach Magnetic Bearing is inherently stable and requires no active feedback control system or superconductivity as required in many magnetic bearing designs. The Axial Halbach Magnetic Bearing is useful for very high speed applications including turbines, instrumentation, medical systems, computer memory systems, and space power systems such as flywheels. Magnetic fields suspend and support a rotor assembly within a stator. Advanced technologies developed for particle accelerators, and currently under development for maglev trains and rocket launchers, served as the basis for this application. Experimental hardware was successfully designed and developed to validate the basic principles and analyses. The report concludes that the implementation of Axial Halbach Magnetic Bearings can provide significant improvements in rotational system performance and reliability.

  15. Axially Symmetric, Spatially Homothetic Spacetimes

    CERN Document Server

    Wagh, S M; Wagh, Sanjay M.; Govinder, Keshlan S.

    2002-01-01

    We show that the existence of appropriate spatial homothetic Killing vectors is directly related to the separability of the metric functions for axially symmetric spacetimes. The density profile for such spacetimes is (spatially) arbitrary and admits any equation of state for the matter in the spacetime. When used for studying axisymmetric gravitational collapse, such solutions do not result in a locally naked singularity.

  16. Thermophoresis of Axially Symmetric Bodies

    Science.gov (United States)

    2007-11-02

    Sweden Abstract. Thermophoresis of axially symmetric bodies is investigated to first order in the Knudsen-mimber, Kn. The study is made in the limit...derived. Asymptotic solutions are studied. INTRODUCTION Thermophoresis as a phenomenon has been known for a long time, and several authors have approached

  17. Axial structure of the nucleon

    Energy Technology Data Exchange (ETDEWEB)

    Veronique Bernard; Latifa Elouadrhiri; Ulf-G Meissner

    2002-01-01

    We review the current status of experimental and theoretical understanding of the axial nucleon structure at low and moderate energies. Topics considered include (quasi)elastic (anti)neutrino-nucleon scattering, charged pion electroproduction off nucleons and ordinary as well as radiative muon capture on the proton.

  18. An Assessment of Combustion Dynamics in a Low-Nox, Second-Generation Swirl-Venturi Lean Direct Injection Combustion Concept

    Science.gov (United States)

    Tacina, K. M.; Chang, C. T.; Lee, P.; Mongia, H.; Podboy, D. P.; Dam, B.

    2015-01-01

    Dynamic pressure measurements were taken during flame-tube emissions testing of three second-generation swirl-venturi lean direct injection (SV-LDI) combustor configurations. These measurements show that combustion dynamics were typically small. However, a small number of points showed high combustion dynamics, with peak-to-peak dynamic pressure fluctuations above 0.5 psi. High combustion dynamics occurred at low inlet temperatures in all three SV-LDI configurations, so combustion dynamics were explored further at low temperature conditions. A point with greater than 1.5 psi peak-to-peak dynamic pressure fluctuations was identified at an inlet temperature of 450!F, a pressure of 100 psia, an air pressure drop of 3%, and an overall equivalence ratio of 0.35. This is an off design condition: the temperature and pressure are typical of 7% power conditions, but the equivalence ratio is high. At this condition, the combustion dynamics depended strongly on the fuel staging. Combustion dynamics could be reduced significantly without changing the overall equivalence ratio by shifting the fuel distribution between stages. Shifting the fuel distribution also decreased NOx emissions.

  19. Fast High Capacity Annular Gas Puff Valve Design Concept

    Science.gov (United States)

    Ruden, Edward

    2000-10-01

    A fast opening gas valve design concept is presented that can theoretically inject a few grams of D2 gas radially outward into a coaxial annular vacuum region with a radius of about 10 cm in less that 100 μ s. The concept employs a single turn 20-30 T pulsed magnetic field coil that axially accelerates an Mg alloy ring, which seals a gas plenum, to high velocity, releasing the gas. Both coil and ring are profiled to minimize stress in the ring. Such a device could be used to supply the initial gas load for a proposed 5 MJ Dense Plasma Focus driven by AFRL's Shiva Star Capacitor bank. The intent here is keep the vacuum current feed insulator under high vacuum during the discharge to avoid surface breakdown. Alternatively, a high energy rep ratable plasma flow opening switch could be supplied with such a valve. This work is funded by the USAF.

  20. Optimization of axial blowers. Optimierung von Axial-Ventilatoren

    Energy Technology Data Exchange (ETDEWEB)

    Bolte, W.

    1992-08-01

    For the optimum possible design of axial blowers, trials are evaluated in the article, which are based on the grid profile examined by N. Scholz. The computation for the pressure number and the primary degree of efficiency are shown as well as the evaluation of the effect of the Reynolds and mach number on the degree of efficiency and determination of the secondary losses. In a final example, the dimensions of a blower are computed from the data determined during the trials. (orig.).

  1. Subcutaneous Injections

    DEFF Research Database (Denmark)

    Thomsen, Maria

    This thesis is about visualization and characterization of the tissue-device interaction during subcutaneous injection. The tissue pressure build-up during subcutaneous injections was measured in humans. The insulin pen FlexTouchr (Novo Nordisk A/S) was used for the measurements and the pressure...... build-up was evaluated indirectly from the changes in the flow rate between subcutaneous injections and air injections. This method enabled the tissue counter pressure to be evaluated without a formal clinical study approval. The measurements were coupled to a model for the pressure evolution...

  2. View of the Axial Field Spectrometer

    CERN Multimedia

    1980-01-01

    The Axial Field Spectrometer, with the vertical uranium/scintillator calorimeter and the central drift chamber retracted for service. One coil of the Open Axial Field Magnet is just visible to the right.

  3. Nonlinear control of variable-displacement self-supplied axial piston pumps; Nichtlineare Regelung von verstellbaren eigenversorgten Axialkolbenpumpen

    Energy Technology Data Exchange (ETDEWEB)

    Fuchshumer, F.; Kemmetmueller, W.; Kugi, A. [Univ. des Saarlandes, Saarbruecken (Germany). Lehrstuhl fuer Systemtheorie und Regelungstechnik

    2007-02-15

    This contribution is concerned with the model-based nonlinear control of a variable-displacement, self-supplied axial piston pump for the application in plastic injection moulding machines. Due to the self-supply mechanism the mathematical model of the pump turns out to be a switched system depending on the direction of movement of the swash plate. The demands on the closed-loop performance with respect to dynamics and stationary accuracy on the assumption of unknown loads are basically derived from the injection process of plastic injection moulding machines. The control concept being derived consists of an inversion-based feedforward controller, an adaptive backstepping controller for the stabilization of the trajectory error system and an estimator for the unknown load. The controller and the estimator design are performed for each subsystem of the overall switched system separately. The stability of the overall closed-loop system can be proven in a systematic way by utilizing the theory of multiple Lyapunov functions. Experimental results on a test-stand show an excellent performance of the closed-loop system for all test scenarios. (orig.)

  4. [Axial spondyloarthritis and ankylosing spondylitis].

    Science.gov (United States)

    Nordström, Dan; Kauppi, Markku

    2010-01-01

    Current classification criteria for ankylosing spondylitis do not allow diagnosis before radiographic changes are visible in sacroiliacal joints. The the new axial spondyloarthropathy (SpA) criteria include axial SpA without radiographic changes as well as established ankylosing spondylitis, recognizing them as a continuum of the same disease. This is of major importance as the burden of early SpA is comparable to that of later stage disease. Diagnosis relies on inflammatory MRI findings which is the most significant change compared to earlier criteria. Emerging data on the efficacy of tumor necrosis factor (TNF) alpha blocking therapies already in early but also in established disease have given new promising alternatives for treatment of this often very cumbersome disease, that rarely responds to classic DMARDs.

  5. Injection MD

    CERN Document Server

    Bartmann, W; Bracco, C; Drosdal, L; Gianfelice, E; Goddard, B; Kain, V; Papaphilippou, Y; Vanbavinckhove, G

    2012-01-01

    This note summarizes the results obtained at injection during the 2nd MD block and the floating MD block in July. Highlights are presented for injection in the LHC with the Q20 SPS optics, influence of the supercycle and injection with 25 ns bunch spacing. Beams were successfully injected into the LHC using the Q20 optics [1, 3]. Small corrections were needed to steer the beam in the transfer lines. Dispersion measurements were conducted for both beams. The horizontal normalized dispersion in TI2 was a factor 2 smaller for Q20 with respect to Q26, for TI8 on the other hand the opposite was observed. The results for injection loss dependency on super cycle composition show only a small increase in losses for beam 2. The losses observed must therefore mainly come from other sources such as shot-by-shot stability or quality of scraping. For the injection with 25 ns bunch spacing bunches were injected for both beams. For B1 up to the maximum of 288 bunches. For B2 on the other only up to 144 bunches were injected...

  6. Subcutaneous Injections

    DEFF Research Database (Denmark)

    Thomsen, Maria

    This thesis is about visualization and characterization of the tissue-device interaction during subcutaneous injection. The tissue pressure build-up during subcutaneous injections was measured in humans. The insulin pen FlexTouchr (Novo Nordisk A/S) was used for the measurements and the pressure...... build-up was evaluated indirectly from the changes in the flow rate between subcutaneous injections and air injections. This method enabled the tissue counter pressure to be evaluated without a formal clinical study approval. The measurements were coupled to a model for the pressure evolution...... in subcutaneous tissue, based on mass conservation and flow in a porous medium. From the measurements the flow permeability and bulk modulus of the tissue were determined. In the adipose tissue the drug forms a bolus from where it is absorbed by the blood capillaries. The spatial distribution of the injected...

  7. Aerodynamic modelling and optimization of axial fans

    Energy Technology Data Exchange (ETDEWEB)

    Noertoft Soerensen, Dan

    1998-01-01

    A numerically efficient mathematical model for the aerodynamics of low speed axial fans of the arbitrary vortex flow type has been developed. The model is based on a blade-element principle, whereby the rotor is divided into a number of annular stream tubes. For each of these stream tubes relations for velocity, pressure and radial position are derived from the conservation laws for mass, tangential momentum and energy. The equations are solved using the Newton-Raphson methods, and solutions converged to machine accuracy are found at small computing costs. The model has been validated against published measurements on various fan configurations, comprising two rotor-only fan stages, a counter-rotating fan unit and a stator-rotor stator stage. Comparisons of local and integrated properties show that the computed results agree well with the measurements. Optimizations have been performed to maximize the mean value of fan efficiency in a design interval of flow rates, thus designing a fan which operates well over a range of different flow conditions. The optimization scheme was used to investigate the dependence of maximum efficiency on 1: the number of blades, 2: the width of the design interval and 3: the hub radius. The degree of freedom in the choice of design variable and constraints, combined with the design interval concept, provides a valuable design-tool for axial fans. To further investigate the use of design optimization, a model for the vortex shedding noise from the trailing edge of the blades has been incorporated into the optimization scheme. The noise emission from the blades was minimized in a flow rate design point. Optimizations were performed to investigate the dependence of the noise on 1: the number of blades, 2: a constraint imposed on efficiency and 3: the hub radius. The investigations showed, that a significant reduction of noise could be achieved, at the expense of a small reduction in fan efficiency. (EG) 66 refs.

  8. Golimumab for treatment of axial spondyloarthritis.

    Science.gov (United States)

    Rios Rodriguez, Valeria; Poddubnyy, Denis

    2016-02-01

    Axial spondyloarthritis comprises two forms: nonradiographic (nonradiographic axial spondyloarthritis) and radiographic (better known as ankylosing spondylitis), which are often considered as two stages of one disease. Historically, all currently available TNF-α inhibitors were first investigated in ankylosing spondylitis and later on in nonradiographic axial spondyloarthritis. This year, EMA has granted golimumab approval for the treatment of active nonradiographic axial spondyloarthritis based on the recently published data from the GO-AHEAD study. This article summarizes recent data on efficacy and safety of golimumab in the treatment of ankylosing spondylitis and nonradiographic axial spondyloarthritis.

  9. Effect of Partial Span Aspiration on the Performance of a Transonic Axial Compressor Rotor: A Numerical Study

    Directory of Open Access Journals (Sweden)

    Vijaykumar Jain

    2015-01-01

    Full Text Available Aspiration in an axial compressor is normally regarded as sucking out the low momentum boundary layer from blade suction surface, thus lowering the chances of flow separation and consequently that of stall under off-design operation. However, the suction mass flow does not take part in useful work and leads to loss of engine power output. This paper deals with a new concept of natural aspiration to energize blade suction surface boundary layer by injecting some fluid from pressure to suction side through a part span slot on the blade. The energized boundary layer has lesser tendency to separate, thus enhancing stall margin. Numerical simulations were carried out to study the effect of aspiration slot location and geometry on the performance and stall margin of a transonic axial compressor rotor. The computational results without aspiration slot were in fair agreement with the published experimental data. The modified rotor, with part span aspiration, showed ~3.2% improvement in stall margin at design rotational speed. The pressure ratio and efficiency of the aspirated rotor dropped by ~1.42% and ~2.0%, respectively, whereas the structural analysis did not indicate any adverse effect on the blade stress distribution in the presence of aspiration slot.

  10. Application of Gaseous Sphere Injection Method for Modeling Under-expanded H2 Injection

    Energy Technology Data Exchange (ETDEWEB)

    Whitesides, R; Hessel, R P; Flowers, D L; Aceves, S M

    2010-12-03

    A methodology for modeling gaseous injection has been refined and applied to recent experimental data from the literature. This approach uses a discrete phase analogy to handle gaseous injection, allowing for addition of gaseous injection to a CFD grid without needing to resolve the injector nozzle. This paper focuses on model testing to provide the basis for simulation of hydrogen direct injected internal combustion engines. The model has been updated to be more applicable to full engine simulations, and shows good agreement with experiments for jet penetration and time-dependent axial mass fraction, while available radial mass fraction data is less well predicted.

  11. Mepolizumab Injection

    Science.gov (United States)

    ... or do not go away: pain, redness, swelling, warmth, burning, or itching in the place mepolizumab was injected headache dry and itchy skin with or without red, scaly rashes back pain muscle spasms Some side ...

  12. Metoclopramide Injection

    Science.gov (United States)

    ... and feeling of fullness that lasts long after meals. Metoclopramide injection is also used to prevent nausea ... tranylcypromine (Parnate); narcotic medications for pain; sedatives; sleeping pills; tetracycline (Bristacycline, Sumycin); tranquilizers. Your doctor may need ...

  13. Ramucirumab Injection

    Science.gov (United States)

    ... dose of ramucirumab injection. Tell your doctor or nurse if you experience any of the following while you receive ramucirumab: uncontrollable shaking of a part of the body; back pain or spasms; chest pain and tightness; chills; flushing; ...

  14. Alemtuzumab Injection

    Science.gov (United States)

    Alemtuzumab injection is used to treat B-cell chronic lymphocytic leukemia (a slowly developing cancer in which ... of white blood cell accumulate in the body). Alemtuzumab is in a class of medications called monoclonal ...

  15. Ferumoxytol Injection

    Science.gov (United States)

    Ferumoxytol injection is used to treat iron-deficiency anemia (a lower than normal number of red blood ... pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or ...

  16. Fludarabine Injection

    Science.gov (United States)

    Fludarabine injection is used to treat chronic lymphocytic leukemia (CLL; a type of cancer of the white ... a reliable method of birth control to prevent pregnancy during this time. Talk to your doctor for ...

  17. Insulin Injection

    Science.gov (United States)

    ... or buttocks. Do not inject insulin into muscles, scars, or moles. Use a different site for each ... you are using insulin.Alcohol may cause a decrease in blood sugar. Ask your doctor about the ...

  18. Tigecycline Injection

    Science.gov (United States)

    ... in a person who was not in the hospital), skin infections, and infections of the abdomen (area between the ... that developed in people who were in a hospital or foot infections in people who have diabetes. Tigecycline injection is ...

  19. Golimumab Injection

    Science.gov (United States)

    Golimumab injection is used alone or with other medications to relieve the symptoms of certain autoimmune disorders ( ... did not help or could not be tolerated. Golimumab is in a class of medications called tumor ...

  20. Albiglutide Injection

    Science.gov (United States)

    ... will develop tumors of the thyroid gland, including medullary thyroid carcinoma (MTC; a type of thyroid cancer). ... symptoms or those listed in the IMPORTANT WARNING section, stop using albiglutide injection and call your doctor ...

  1. Dexamethasone Injection

    Science.gov (United States)

    ... body tissues,) gastrointestinal disease, and certain types of arthritis. Dexamethasone injection is also used for diagnostic testing. ... effects.tell your doctor if you have a fungal infection (other than on your skin or nails). ...

  2. Hydrocortisone Injection

    Science.gov (United States)

    ... own organs), gastrointestinal disease, and certain types of arthritis. Hydrocortisone injection is also used to treat certain ... effects.tell your doctor if you have a fungal infection (other than on your skin or nails). ...

  3. Methylprednisolone Injection

    Science.gov (United States)

    ... own organs), gastrointestinal disease, and certain types of arthritis. Methylprednisolone injection is also used to treat certain ... effects.tell your doctor if you have a fungal infection (other than on your skin or nails). ...

  4. Glatiramer Injection

    Science.gov (United States)

    ... To inject glatiramer, follow these steps: Remove one blister pack from the carton of glatiramer syringes and place ... paper label and remove the syringe from the blister pack. Check your prefilled syringe to be sure it ...

  5. Dexrazoxane Injection

    Science.gov (United States)

    ... that are used to treat or prevent certain side effects that may be caused by chemotherapy medications. Dexrazoxane injection (Zinecard) is used to prevent or decrease heart damage caused by doxorubicin in women who are ...

  6. Evolocumab Injection

    Science.gov (United States)

    ... autoinjector in hot water, microwave, or place in sunlight.Before you use evolocumab injection, look at the ... chills pain or burning during urination muscle or back pain dizziness stomach pain Some side effects can be ...

  7. Cidofovir Injection

    Science.gov (United States)

    Cidofovir injection is used along with another medication (probenecid) to treat cytomegaloviral retinitis (CMV retinitis) in people with acquired immunodeficiency syndrome (AIDS). Cidofovir is in a class of medications called antivirals. ...

  8. Brivaracetam Injection

    Science.gov (United States)

    ... older. Brivaracetam in a class of medications called anticonvulsants. It works by decreasing abnormal electrical activity in ... older (about 1 in 500 people) who took anticonvulsants like brivaracetam injection to treat various conditions during ...

  9. Diphenhydramine Injection

    Science.gov (United States)

    ... not to use diphenhydramine injection if you are breastfeeding because of the risk of harm to infants.tell your doctor if you have or have ever had asthma or other types of lung disease; glaucoma (a ...

  10. Cefazolin Injection

    Science.gov (United States)

    ... valve, respiratory tract (including pneumonia), biliary tract, and urinary tract infections. Cefazolin injection also may be used before, during, ... to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( ...

  11. Ceftazidime Injection

    Science.gov (United States)

    ... skin, blood, bone, joint, female genital tract, and urinary tract infections. Ceftazidime injection is in a class of medications ... to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( ...

  12. Fluconazole Injection

    Science.gov (United States)

    ... and fungal infections of the eye, prostate (a male reproductive organ), skin and nails. Fluconazole injection is ... Motrin, others) and naproxen (Aleve, Anaprox, Naprelan); oral contraceptives (birth control pills); oral medication for diabetes such ...

  13. Moxifloxacin Injection

    Science.gov (United States)

    ... available.Moxifloxacin injection is in a class of antibiotics called fluoroquinolones. It works by killing the bacteria that cause ... you are allergic to moxifloxacin, other quinolone or fluoroquinolone antibiotics such as ciprofloxacin (Cipro), gatifloxacin (Tequin) (not available ...

  14. Levofloxacin Injection

    Science.gov (United States)

    ... available. Levofloxacin injection is in a class of antibiotics called fluoroquinolones. It works by killing bacteria that cause infections. ... severe reaction to levofloxacin; any other quinolone or fluoroquinolone antibiotic such as ciprofloxacin (Cipro), gatifloxacin (Tequin) (not available ...

  15. Ciprofloxacin Injection

    Science.gov (United States)

    ... available. Ciprofloxacin injection is in a class of antibiotics called fluoroquinolones. It works by killing bacteria that cause infections. ... reaction to ciprofloxacin or any other quinolone or fluoroquinolone antibiotic such as gatifloxacin (Tequin) (not available in the ...

  16. Alirocumab Injection

    Science.gov (United States)

    ... further decrease the amount of low-density lipoprotein (LDL) cholesterol ('bad cholesterol') in the blood. Alirocumab injection is ... antibodies. It works by blocking the production of LDL cholesterol in the body to decrease the amount of ...

  17. Chloramphenicol Injection

    Science.gov (United States)

    ... an arm or leg sudden changes in vision pain with eye movement Chloramphenicol injection may cause a condition called gray syndrome in premature and newborn infants. There have also been reports of gray ...

  18. Imaging results and TOF studies with axial PET detectors

    CERN Document Server

    Joram, Christian

    2013-01-01

    We have developed a fully operational PET demonstrator setup which allows true 3D reconstruction of the 511 keV photons and therefore leads to practically parallax free images. The AX-PET concept is based on thin 100 mm long scintillation crystals (LYSO), axially oriented and arranged in layers around the held of view. Layers of wavelength shifting plastic strips mounted in between the crystal layers give the axial coordinate. Both crystals and WLS strips are individually read out by G-APD (SiPM) photodetectors. The Fully scalable concept overcomes the dilemma of sensitivity versus spatial resolution which is inherent to classical PET designs. A demonstrator set-up based on two axial modules was exhaustively characterized using point-like sources, phantoms filled with radiotracer and finally rats and a mouse. The results entirely meet the performance expectations ( <2 mm FWHM in all three coordinates over the complete held of view) and also demonstrated the ability to include Compton interactions (inter-cr...

  19. Axial Globe Length in Congenital Ptosis.

    Science.gov (United States)

    Takahashi, Yasuhiro; Kang, Hyera; Kakizaki, Hirohiko

    2015-01-01

    To compare axial globe length between affected and unaffected sides in patients with unilateral congenital ptosis. This prospective observational study included 37 patients (age range: 7 months to 58 years). The axial globe length, margin reflex distance-1 (MRD-1), and refractive power were measured. The axial globe length difference was calculated by subtracting the axial globe length on the unaffected side from that of the affected side. The relationships among axial globe length differences, MRD-1 on the affected sides, and patient ages were analyzed using multiple regression analysis. No significant differences were found in the axial globe length between sides (P = .677). The axial globe length difference was 0.17 ± 0.30 mm (mean ± standard deviation), and two patients (5.4%), aged 32 to 57 years, showed axial globe length more than 0.67 mm longer (corresponding to a refractive power of 2 diopters) on the affected side compared to the unaffected side. The multiple regression model between axial globe length difference, patient age, and MRD-1 on the affected sides was less appropriate (YAGL = 0.003XAGE-0.048XMRD-1 +0.112; r = 0.338; adjusted r2 = 0.062; P = .127). The cylindrical power was greater on the affected side (P = .046), although the spherical power was not different between sides (P = .657). No significant difference was identified in the axial globe length between sides, and only 5% of non-pediatric patients showed an axial globe length more than 0.67 mm longer on the affected side. Congenital ptosis may have little effect on axial globe length elongation, and the risk of axial myopia-induced anisometropic amblyopia may be low in patients with unilateral congenital ptosis. Copyright 2015, SLACK Incorporated.

  20. Axial Vector $Z'$ and Anomaly Cancellation

    CERN Document Server

    Ismail, Ahmed; Tsao, Kuo-Hsing; Unwin, James

    2016-01-01

    Whilst the prospect of new $Z'$ gauge bosons with only axial couplings to the Standard Model (SM) fermions is widely discussed, examples of anomaly-free renormalisable models are lacking in the literature. We look to remedy this by constructing several motivated examples. Specifically, we consider axial vectors which couple universally to all SM fermions, as well as those which are generation-specific, leptophilic, and leptophobic. Anomaly cancellation typically requires the presence of new coloured and charged chiral fermions, and we argue that the masses of these new states must generally be comparable to that of the axial vector. Finally, an axial vector mediator could provide a portal between SM and hidden sector states, and we also consider the possibility that the axial vector couples to dark matter. If the dark matter relic density is set due to freeze-out via the axial vector, this strongly constrains the parameter space.

  1. Axial vector Z‧ and anomaly cancellation

    Science.gov (United States)

    Ismail, Ahmed; Keung, Wai-Yee; Tsao, Kuo-Hsing; Unwin, James

    2017-05-01

    Whilst the prospect of new Z‧ gauge bosons with only axial couplings to the Standard Model (SM) fermions is widely discussed, examples of anomaly-free renormalisable models are lacking in the literature. We look to remedy this by constructing several motivated examples. Specifically, we consider axial vectors which couple universally to all SM fermions, as well as those which are generation-specific, leptophilic, and leptophobic. Anomaly cancellation typically requires the presence of new coloured and charged chiral fermions, and we argue that in a large class of models masses of these new states are expected to be comparable to that of the axial vector. Finally, an axial vector mediator could provide a portal between SM and hidden sector states, and we also consider the possibility that the axial vector couples to dark matter. If the dark matter relic density is set due to freeze-out via the axial vector, this strongly constrains the parameter space.

  2. Diabetes mellitus and the eye: axial length

    OpenAIRE

    Huntjens, B.; O’Donnell, C.

    2006-01-01

    Background and aims: The refractive error of the eye is dependent on its axial length. Refractive error is known to fluctuate significantly in poorly controlled diabetic patients. Recently it has been reported that human eyes fluctuate in axial length during the day. However, this change is not detectable in all subjects, suggesting physiological influences such as diet. The purpose of this study was to investigate fluctuations in axial length and blood glucose levels (BGLs) in diabetic patie...

  3. Axial Vibration Confinement in Nonhomogenous Rods

    Directory of Open Access Journals (Sweden)

    S. Choura

    2005-01-01

    Full Text Available A design methodology for the vibration confinement of axial vibrations in nonhomogenous rods is proposed. This is achieved by a proper selection of a set of spatially dependent functions characterizing the rod material and geometric properties. Conditions for selecting such properties are established by constructing positive Lyapunov functions whose derivative with respect to the space variable is negative. It is shown that varying the shape of the rod alone is sufficient to confine the vibratory motion. In such a case, the vibration confinement requires that the eigenfunctions be exponentially decaying functions of space, where the notion of spatial domain stability is introduced as a concept dual to that of the time domain stability. It is also shown that vibration confinement can be produced if the rod density and/or stiffness are varied with respect to the space variable while the cross-section area is kept constant. Several case studies, supporting the developed conditions imposed on the spatially dependent functions for vibration confinement in vibrating rods, are discussed. Because variation in the geometric and material properties might decrease the critical buckling loads, we also discuss the buckling problem.

  4. System Study for Axial Vane Engine Technology

    Science.gov (United States)

    Badley, Patrick R.; Smith, Michael R.; Gould, Cedric O.

    2008-01-01

    The purpose of this engine feasibility study was to determine the benefits that can be achieved by incorporating positive displacement axial vane compression and expansion stages into high bypass turbofan engines. These positive-displacement stages would replace some or all of the conventional compressor and turbine stages in the turbine engine, but not the fan. The study considered combustion occurring internal to an axial vane component (i.e., Diesel engine replacing the standard turbine engine combustor, burner, and turbine); and external continuous flow combustion with an axial vane compressor and an axial vane turbine replacing conventional compressor and turbine systems.

  5. Unsteady Flows in Axial Turbomachines

    Science.gov (United States)

    Marble, F. E.; Rannie, W. D.

    1957-01-01

    Of the various unsteady flows that occur in axial turbomachines certain asymmetric disturbances, of wave length large in comparison with blade spacing, have become understood to a certain extent. These disturbances divide themselves into two categories: self-induced oscillations and force disturbances. A special type of propagating stall appears as a self-induced disturbance; an asymmetric velocity profile introduced at the compressor inlet constitutes a forced disturbance. Both phenomena have been treated from a unified theoretical point of view in which the asymmetric disturbances are linearized and the blade characteristics are assumed quasi-steady. Experimental results are in essential agreement with this theory wherever the limitations of the theory are satisfied. For the self-induced disturbances and the more interesting examples of the forced disturbances, the dominant blade characteristic is the dependence of total pressure loss, rather than the turning angle, upon the local blade inlet angle.

  6. The Emergence of Axial Parts

    Directory of Open Access Journals (Sweden)

    Peter Svenonius

    2007-01-01

    Full Text Available Many languages have specialized locative words or morphemes translating roughly into words like ‘front,’ ‘back,’ ‘top,’ ‘bottom,’ ‘side,’ and so on. Often, these words are used instead of more specialized adpositions to express spatial meanings corresponding to ‘behind,’ ‘above,’ and so on. I argue, on the basis of a cross-linguistic survey of such expressions, that in many cases they motivate a syntactic category which is distinct from both N and P, which I call AxPart for ‘Axial Part’; I show how the category relates to the words which instantiate it, and how the meaning of the construction is derived from the combination of P[lace] elements, AxParts, and the lexical material which expresses them.

  7. Emission Characteristics of A P and W Axially Staged Sector Combustor

    Science.gov (United States)

    He, Zhuohui J.; Wey, Changlie; Chang, Clarence T.; Lee, Chi Ming; Surgenor, Angela D.; Kopp-Vaughan, Kristin; Cheung, Albert

    2016-01-01

    Emission characteristics of a three-cup P and W Axially Controlled Stoichiometry (ACS) sector combustor are reported in this article. Multiple injection points and fuel staging strategies are used in this combustor design. Pilot-stage injectors are located on the front dome plate of the combustor, and main-stage injectors are positioned on the top and bottom of the combustor liners downstream. Low power configuration uses only pilot-stage injectors. Main-stage injectors are added to high power configuration to help distribute fuel more evenly and achieve overall lean burn yielding very low NOx emissions. Combustion efficiencies at four ICAO LTO conditions were all above 99%. Three EINOx emissions correlation equations were developed based on the experimental data to describe the NOx emission trends of this combustor concept. For the 7% and 30% engine power conditions, NOx emissions are obtained with the low power configuration, and the EINOx values are 6.16 and 6.81. The high power configuration was used to assess 85% and 100% engine power NOx emissions, with measured EINOx values of 4.58 and 7.45, respectively. The overall landing-takeoff cycle NOx emissions are about 12% relative to ICAO CAEP/6 level.

  8. Sarilumab Injection

    Science.gov (United States)

    ... the needle. Do not try to warm the medication by heating it in a microwave, placing it in warm water or in direct sunlight, or through any other method.Before injecting, check the prefilled syringe to be sure that the expiration date printed on the package has not passed. Look ...

  9. Enfuvirtide Injection

    Science.gov (United States)

    ... inject enfuvirtide into any skin that has a tattoo, scar, bruise, mole, a burn site, or has ... Enfuvirtide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: itching, swelling, pain, tingling, discomfort, ...

  10. Fluorouracil Injection

    Science.gov (United States)

    ... of a doctor who is experienced in giving chemotherapy medications for cancer. Treatment with fluorouracil injection may cause serious side effects. ... this medication.If you experience a serious side effect, you or your doctor ... (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/ ...

  11. Lanreotide Injection

    Science.gov (United States)

    Lanreotide injection is used to treat people with acromegaly (condition in which the body produces too much growth hormone, causing enlargement of the hands, feet, and facial features; joint pain; and other symptoms) who have not successfully, or cannot be treated ...

  12. Paliperidone Injection

    Science.gov (United States)

    ... the body slow movements or shuffling walk painful erection of the penis that lasts for hours cough, chills and/or other signs of infection Paliperidone injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.If you experience a ...

  13. Ziprasidone Injection

    Science.gov (United States)

    ... stiffness falling confusion sweating loss of consciousness painful erection of the penis that lasts for hours Ziprasidone injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.If you experience a ...

  14. Risperidone Injection

    Science.gov (United States)

    ... control slow movements or shuffling walk falling painful erection of the penis that lasts for hours Risperidone extended-release injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.If you experience a ...

  15. Health and imaging outcomes in axial spondyloarthritis

    NARCIS (Netherlands)

    Machado, P.M.

    2016-01-01

    This thesis focuses on the assessment and monitoring of health and imaging outcomes in axial spondyloarthritis (SpA) and the relationship between these outcomes. Four major contributions to the understanding and management of axial SpA were made: 1) the improvement and facilitation of the assessment

  16. Controllable rectification of the axial expansion in the thermally driven artificial muscle

    Science.gov (United States)

    Yue, Donghua; Zhang, Xingyi; Yong, Huadong; Zhou, Jun; Zhou, You-He

    2015-09-01

    At present, the concept of artificial muscle twisted by polymers or fibers has become a hot issue in the field of intelligent material research according to its distinguishing advantages, e.g., high energy density, large-stroke, non-hysteresis, and inexpensive. The axial thermal expansion coefficient is an important parameter which can affect its demanding applications. In this letter, a device with high accuracy capacitive sensor is constructed to measure the axial thermal expansion coefficient of the twisted carbon fibers and yarns of Kevlar, and a theoretical model based on the thermal elasticity and the geometrical features of the twisted structure are also presented to predict the axial expansion coefficient. It is found that the calculated results take good agreements with the experimental data. According to the present experiment and analyses, a method to control the axial thermal expansion coefficient of artificial muscle is proposed. Moreover, the mechanism of this kind of thermally driven artificial muscle is discussed.

  17. Subcutaneous (SQ) injections

    Science.gov (United States)

    SQ injections; Sub-Q injections; Diabetes subcutaneous injection; Insulin subcutaneous injection ... NIH. Giving a subcutaneous injection . Rockville, MD. National ... of Health and Human Services NIH publications; 2015. Available ...

  18. Universal Axial Fluctuations in Optical Tweezers

    CERN Document Server

    Ribezzi-Crivellari, Marco; Ritort, Felix

    2015-01-01

    Optical tweezers allow the measurement of fluctuations at the nano-scale, in particular fluctuations in the end-to-end distance in single molecules. Fluctuation spectra can yield valuable information, but they can easily be contaminated by instrumental effects. We identify axial fluctuations, i.e. fluctuations of the trapped beads in the direction of light propagation, as one of these instrumental effects. Remarkably, axial fluctuations occur on a characteristic timescale similar to that of conformational (folding) transitions, which may lead to misinterpretation of the experimental results. We show that a precise measurement of the effect of force on both axial and conformational fluctuations is crucial to disentangle them. Our results on axial fluctuations are captured by a simple and general formula valid for all optical tweezers setups and provide experimentalists with a general strategy to distinguish axial fluctuations from conformational transitions.

  19. Novel Integration Radial and Axial Magnetic Bearing

    Science.gov (United States)

    Blumenstock, Kenneth; Brown, Gary

    2000-01-01

    Typically, fully active magnetically suspended systems require one axial and two radial magnetic bearings. Combining radial and axial functions into a single device allows for more compact and elegant packaging. Furthermore, in the case of high-speed devices such as energy storage flywheels, it is beneficial to minimize shaft length to keep rotor mode frequencies as high as possible. Attempts have been made to combine radial and axial functionality, but with certain drawbacks. One approach requires magnetic control flux to flow through a bias magnet reducing control effectiveness, thus resulting in increased resistive losses. This approach also requires axial force producing magnetic flux to flow in a direction into the rotor laminate that is undesirable for minimizing eddy-current losses resulting in rotational losses. Another approach applies a conical rotor shape to what otherwise would be a radial heteropolar magnetic bearing configuration. However, positional non-linear effects are introduced with this scheme and the same windings are used for bias, radial, and axial control adding complexity to the controller and electronics. For this approach, the amount of axial capability must be limited. It would be desirable for an integrated radial and axial magnetic bearing to have the following characteristics; separate inputs for radial and axial control for electronics and control simplicity, all magnetic control fluxes should only flow through their respective air gaps and should not flow through any bias magnets for minimal resistive losses, be of a homopolar design to minimize rotational losses, position related non-linear effects should be minimized, and dependent upon the design parameters, be able to achieve any radial/axial force or power ratio as desired. The integrated radial and axial magnetic bearing described in this paper exhibits all these characteristics. Magnetic circuit design, design equations, and magnetic field modeling results will be presented.

  20. Novel Integrated Radial and Axial Magnetic Bearing

    Science.gov (United States)

    Blumenstock, Kenneth A.; Brown, Gary L.; Powers, Edward I. (Technical Monitor)

    2000-01-01

    Typically, fully active magnetically suspended systems require one axial and two radial magnetic bearings. Combining radial and axial functions into a single device allows for more compact and elegant packaging. Furthermore, in the case of high-speed devices such as energy storage flywheels, it is beneficial to minimize shaft length to keep rotor mode frequencies as high as possible. Attempts have been made to combine radial and axial functionality, but with certain drawbacks. One approach requires magnetic control flux to flow through a bias magnet reducing control effectiveness, thus resulting in increased resistive losses. This approach also requires axial force producing magnetic flux to flow in a direction into the rotor laminate that is undesirable for minimizing eddy-current losses resulting in rotational losses. Another approach applies a conical rotor shape to what otherwise would be a radial heteropolar magnetic bearing configuration. However, positional non-linear effects are introduced with this scheme and the same windings are used for bias, radial, and axial control adding complexity to the controller and electronics. For this approach, the amount of axial capability must be limited. It would be desirable for an integrated radial and axial magnetic bearing to have the following characteristics, separate inputs for radial and axial control for electronics and control simplicity, all magnetic control fluxes should only flow through their respective air gaps and should not flow through any bias magnets for minimal resistive losses, be of a homopolar design to minimize rotational losses, position related non-linear effects should be minimized, and dependent upon the design parameters, be able to achieve any radial/axial force or power ratio as desired. The integrated radial and axial magnetic bearing described in this paper exhibits all these characteristics. Magnetic circuit design, design equations, and analysis results will be presented.

  1. ASAS classification criteria for axial spondyloarthritis: time to modify.

    Science.gov (United States)

    Akkoc, Nurullah; Khan, Muhammad A

    2016-06-01

    The relationship between ankylosing spondylitis and the recently proposed entity called axial spondyloarthritis with its radiographic and non-radiographic forms that have been defined by the Assessment of Spondyloarthritis International Society (ASAS) criteria for axial spondyloarthritis (axSpA), is currently being debated. The Food and Drug Agency (FDA) had criticized the ASAS criteria and the studies which used these criteria to enroll patients in a clinical trial of certolizumab and adalimumab for the treatment of non-radiographic axial spondyloarthritis. The primary aim of classification criteria is to create homogenous patient populations for basic and clinical research. But the multi-arm construct of the ASAS criteria is a potential source of heterogeneity reducing their utility. Criteria sets should be regarded as dynamic concepts open to modifications or updates as our knowledge advances. We provide evidence to conclude that it is time to modify the ASAS Criteria for axSpA, and we propose some of the steps that can be taken to start moving forward in improving the validity of these criteria.

  2. Experimental Investigations of Micro Air Injection to Control Rotating Stall

    Institute of Scientific and Technical Information of China (English)

    Chaoqun Nie; Zhiting Tong; Shaojuan Geng; Junqiang Zhu; Weiguang Huang

    2007-01-01

    Steady discrete micro air injection at the tip region in front of the first compressor rotor has been proved to be an effective method to delay the inception of rotating stall in a low speed axial compressor. Considering the practical application a new type of micro injector was designed and described in this paper, which was imbedded in the casing and could be moved along the chord. In order to verify its feasibility to other cases, such as high subsonic axial compressor or centrifugal compressor, some other cases have been studied. Experimental results of the same low speed axial compressor showed that the new injector could possess many other advantages besides successfully stabilizing the compressor. Experiments performed on a high subsonic axial compressor confirmed the effectiveness of micro air injection when the relative velocity at the blade tip is high subsonic. Meanwhile in order to explore its feasibility in centrifugal compressor, a similar micro injector was designed and tested on a low speed centrifugal compressor with vaned diffuser. The injected mass flow was a bit larger than that used in axial compressors and the results showed micro injection could also delay the onset of rotating stall in the centrifugal compressor.

  3. Towards spin injection into silicon

    Energy Technology Data Exchange (ETDEWEB)

    Dash, S.P.

    2007-08-15

    Si has been studied for the purpose of spin injection extensively in this thesis. Three different concepts for spin injection into Si have been addressed: (1) spin injection through a ferromagnet-Si Schottky contact, (2) spin injection using MgO tunnel barriers in between the ferromagnet and Si, and (3) spin injection from Mn-doped Si (DMS) as spin aligner. (1) FM-Si Schottky contact for spin injection: To be able to improve the interface qualities one needs to understand the atomic processes involved in the formation of silicide phases. In order to obtain more detailed insight into the formation of such phases the initial stages of growth of Co and Fe were studied in situ by HRBS with monolayer depth resolution.(2) MgO tunnel barrier for spin injection into Si: The fabrication and characterization of ultra-thin crystalline MgO tunnel barriers on Si (100) was presented. (3) Mn doped Si for spin injection: Si-based diluted magnetic semiconductor samples were prepared by doping Si with Mn by two different methods i) by Mn ion implantation and ii) by in-diffusion of Mn atoms (solid state growth). (orig.)

  4. Axial force measurement for esophageal function testing

    Institute of Scientific and Technical Information of China (English)

    Flemming H Gravesen; Peter Funch-Jensen; Hans Gregersen; Asbjφrn Mohr Drewes

    2009-01-01

    The esophagus serves to transport food and fluid from the pharynx to the stomach. Manometry has been the "golden standard" for the diagnosis of esophageal motility diseases for many decades. Hence, esophageal function is normally evaluated by means of manometry even though it reflects the squeeze force (force in radial direction) whereas the bolus moves along the length of esophagus in a distal direction. Force measurements in the longitudinal (axial) direction provide a more direct measure of esophageal transport function. The technique used to record axial force has developed from external force transducers over in-vivo strain gauges of various sizes to electrical impedance based measurements. The amplitude and duration of the axial force has been shown to be as reliable as manometry. Normal, as well as abnormal, manometric recordings occur with normal bolus transit, which have been documented using imaging modalities such as radiography and scintigraphy. This inconsistency using manometry has also been documented by axial force recordings. This underlines the lack of information when diagnostics are based on manometry alone. Increasing the volume of a bag mounted on a probe with combined axial force and manometry recordings showed that axial force amplitude increased by 130% in contrast to an increase of 30% using manometry. Using axial force in combination with manometry provides a more complete picture of esophageal motility, and the current paper outlines the advantages of using this method.

  5. Axial force measurement for esophageal function testing.

    Science.gov (United States)

    Gravesen, Flemming H; Funch-Jensen, Peter; Gregersen, Hans; Drewes, Asbjørn Mohr

    2009-01-14

    The esophagus serves to transport food and fluid from the pharynx to the stomach. Manometry has been the "golden standard" for the diagnosis of esophageal motility diseases for many decades. Hence, esophageal function is normally evaluated by means of manometry even though it reflects the squeeze force (force in radial direction) whereas the bolus moves along the length of esophagus in a distal direction. Force measurements in the longitudinal (axial) direction provide a more direct measure of esophageal transport function. The technique used to record axial force has developed from external force transducers over in-vivo strain gauges of various sizes to electrical impedance based measurements. The amplitude and duration of the axial force has been shown to be as reliable as manometry. Normal, as well as abnormal, manometric recordings occur with normal bolus transit, which have been documented using imaging modalities such as radiography and scintigraphy. This inconsistency using manometry has also been documented by axial force recordings. This underlines the lack of information when diagnostics are based on manometry alone. Increasing the volume of a bag mounted on a probe with combined axial force and manometry recordings showed that axial force amplitude increased by 130% in contrast to an increase of 30% using manometry. Using axial force in combination with manometry provides a more complete picture of esophageal motility, and the current paper outlines the advantages of using this method.

  6. New Anomaly of the Axial-Vector Current

    Institute of Scientific and Technical Information of China (English)

    HE Han-Xin

    2001-01-01

    By computing the axial-vector current operator equation, we find the anomalous axial-vector curl equation besides the well-known anomalous axial-vector divergence equation (the Adler-Bell-Jackiw anomaly) and discuss its implication.``

  7. The AX-PET project Demonstration of a high resolution axial 3D PET

    CERN Document Server

    Bolle, E; Casella, C; Chesi, E; Clinthorne, N; Cochran, E; De Leo, R; Dissertori, G; Djambazov, G; Fanti, V; Honscheid, K; Huh, S; Johnson, I; Joram, C; Kagan, H; Lustermann, W; Meddi, F; Nappi, E; Nessi-Tedaldi, F; Oliver, J F; Pauss, P; Rafecas, M; Renker, D; Rudge, A; Schinzel, D; Schneider, T; Seguinot, J; Smith, S; Solevi, P; Stapnes, S; Weilhammer, P

    2010-01-01

    The AX-PET is a new geometrical concept for a high resolution 3D PET scanner, based on matrices of axially oriented LYSO crystals interleaved by stacks of WLS, both individually read out by G-APDs. A PET demonstrator, based on two detector modules used in coincidence, is currently under construction.

  8. Axial force measurement for esophageal function testing

    DEFF Research Database (Denmark)

    Gravesen, Flemming Holbæk; Funch-Jensen, Peter; Gregersen, Hans

    2009-01-01

    force transducers over in-vivo strain gauges of various sizes to electrical impedance based measurements. The amplitude and duration of the axial force has been shown to be as reliable as manometry. Normal, as well as abnormal, manometric recordings occur with normal bolus transit, which have been...... force (force in radial direction) whereas the bolus moves along the length of esophagus in a distal direction. Force measurements in the longitudinal (axial) direction provide a more direct measure of esophageal transport function. The technique used to record axial force has developed from external...... documented using imaging modalities such as radiography and scintigraphy. This inconsistency using manometry has also been documented by axial force recordings. This underlines the lack of information when diagnostics are based on manometry alone. Increasing the volume of a bag mounted on a probe...

  9. Axial Super-resolution Evanescent Wave Tomography

    CERN Document Server

    Pendharker, Sarang; Newman, Ward; Ogg, Stephen; Nazemifard, Neda; Jacob, Zubin

    2016-01-01

    Optical tomographic reconstruction of a 3D nanoscale specimen is hindered by the axial diffraction limit, which is 2-3 times worse than the focal plane resolution. We propose and experimentally demonstrate an axial super-resolution evanescent wave tomography (AxSET) method that enables the use of regular evanescent wave microscopes like Total Internal Reflection Fluorescence Microscope (TIRF) beyond surface imaging, and achieve tomographic reconstruction with axial super-resolution. Our proposed method based on Fourier reconstruction achieves axial super-resolution by extracting information from multiple sets of three-dimensional fluorescence images when the sample is illuminated by an evanescent wave. We propose a procedure to extract super-resolution features from the incremental penetration of an evanescent wave and support our theory by 1D (along the optical axis) and 3D simulations. We validate our claims by experimentally demonstrating tomographic reconstruction of microtubules in HeLa cells with an axi...

  10. How to diagnose axial spondyloarthritis early

    OpenAIRE

    Rudwaleit, M.; van der Heijde, D.; Khan, M.; Braun, J.; Sieper, J.

    2004-01-01

    Background: Chronic low back pain (LBP), the leading symptom of ankylosing spondylitis (AS) and undifferentiated axial spondyloarthritis (SpA), precedes the development of radiographic sacroiliitis, sometimes by many years.

  11. Axial thermal rotation of slender rods.

    Science.gov (United States)

    Li, Dichuan; Fakhri, Nikta; Pasquali, Matteo; Biswal, Sibani Lisa

    2011-05-06

    Axial rotational diffusion of rodlike polymers is important in processes such as microtubule filament sliding and flagella beating. By imaging the motion of small kinks along the backbone of chains of DNA-linked colloids, we produce a direct and systematic measurement of axial rotational diffusivity of rods both in bulk solution and near a wall. The measured diffusivities decrease linearly with the chain length, irrespective of the distance from a wall, in agreement with slender-body hydrodynamics theory. Moreover, the presence of small kinks does not affect the chain's axial diffusivity. Our system and measurements provide insights into fundamental axial diffusion processes of slender objects, which encompass a wide range of entities including biological filaments and linear polymer chains.

  12. Nonperturbative Aspects of Axial Vector Vertex

    Institute of Scientific and Technical Information of China (English)

    ZONG Hong-Shi; CHEN Xiang-Song; WANG Fan; CHANG Chao-Hsi; ZHAO En-Guang

    2002-01-01

    It is shown how the axial vector current of current quarks is related to that of constituent quarks within the framework of the global color symmetry model.Gluon dressing of the axial vector vertex and the quark self-energy functions are described by the inhomogeneous Bethe-Salpeter equation in the ladder approximation and the Schwinger Dyson equation in the rainbow approximation,respectively.

  13. Numerical simulation of axial flow compressors.

    OpenAIRE

    Jesuino Takachi Tomita

    2002-01-01

    This work deals with the numerical simulation of axial flow compressors, from design to performance prediction. The stage performance prediction uses the meanline flow properties. Stage-stacking is used to analyse a multi-stage compressor. A computer program, written in FORTRAN, was developed and is able to design an axial flow compressor given air mass flow, total pressure ratio, overall efficiency and design speed. All geometrical data relevant to the compressor performance prediction is ca...

  14. Automatic Generation of the Axial Lines of Urban Environments to Capture What We Perceive

    CERN Document Server

    Jiang, Bin

    2008-01-01

    Based on the concepts of isovists and medial axes, we developed a set of algorithms that can automatically generate the axial lines for representing individual linearly stretched parts of open space of an urban environment. Open space is the space between buildings, where people can freely move around. The generation of the axial lines has been a key aspect of space syntax research, conventionally relying on hand-drawn axial lines of an urban environment, often called the axial map, for urban morphological analysis. Although various attempts have been made towards an automatic solution, few of them can produce the axial map that is identical to the hand-drawn one, and none of them really works for different urban environments. Our algorithms are proved to provide a better solution than existing ones. Throughout this paper, we have also argued and demonstrated that the axial lines constitute a true skeleton, superior to the medial axes, in capturing what we perceive about the urban environment. Keywords: Visib...

  15. Wave propagation in axially moving periodic strings

    Science.gov (United States)

    Sorokin, Vladislav S.; Thomsen, Jon Juel

    2017-04-01

    The paper deals with analytically studying transverse waves propagation in an axially moving string with periodically modulated cross section. The structure effectively models various relevant technological systems, e.g. belts, thread lines, band saws, etc., and, in particular, roller chain drives for diesel engines by capturing both their spatial periodicity and axial motion. The Method of Varying Amplitudes is employed in the analysis. It is shown that the compound wave traveling in the axially moving periodic string comprises many components with different frequencies and wavenumbers. This is in contrast to non-moving periodic structures, for which all components of the corresponding compound wave feature the same frequency. Due to this "multi-frequency" character of the wave motion, the conventional notion of frequency band-gaps appears to be not applicable for the moving periodic strings. Thus, for such structures, by frequency band-gaps it is proposed to understand frequency ranges in which the primary component of the compound wave attenuates. Such frequency band-gaps can be present for a moving periodic string, but only if its axial velocity is lower than the transverse wave speed, and, the higher the axial velocity, the narrower the frequency band-gaps. The revealed effects could be of potential importance for applications, e.g. they indicate that due to spatial inhomogeneity, oscillations of axially moving periodic chains always involve a multitude of frequencies.

  16. An Unbroken Axial Vector Current Conservation Law

    CERN Document Server

    Sharafiddinov, Rasulkhozha S

    2015-01-01

    The mass, energy and momentum of the neutrino of a true flavor have an axial-vector nature. As a consequence, the left-handed truly neutral neutrino in an axial-vector field of emission can be converted into a right-handed one and vice versa. This predicts the unidenticality of masses, energies and momenta of neutrinos of the different components. Recognizing such a difference in masses, energies, momenta and accepting that the left-handed axial-vector neutrino and the right-handed antineutrino of true neutrality refer to long-lived C-odd leptons, and the right-handed truly neutral neutrino and the left-handed axial-vector antineutrino are of short-lived fermions of C-oddity, we would write a new CP-even Dirac equation taking into account the flavor symmetrical axial-vector mass, energy and momentum matrices. Their presence explains the spontaneous mirror symmetry violation, confirming that an axial-vector current conservation law has never violated. They reflect the availability of a mirror Minkowski space i...

  17. Injection System design for a hadron therapy Synchrotron

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jin-Quan; SONG Ming-Tao; WEI Bao-Wen

    2008-01-01

    A synchrotron is designed for tumour therapy with C6+ ions or proton.Its injector is a cyclotron, which delivers C5+or H+2 ions to the synchrotron.After comparing the methods of the single-turn injection, the multi-turn injection and the stripping injection,this paper chooses the stripping injection method.In addition,the concept design of the injection system is presented,in which the synchrotron lattice is optimized.

  18. Plasma Injection Schemes for Laser-Plasma Accelerators

    OpenAIRE

    J. Faure

    2017-01-01

    Plasma injection schemes are crucial for producing high-quality electron beams in laser-plasma accelerators. This article introduces the general concepts of plasma injection. First, a Hamiltonian model for particle trapping and acceleration in plasma waves is introduced; ionization injection and colliding-pulse injection are described in the framework of this Hamiltonian model. We then proceed to consider injection in plasma density gradients.

  19. Mandibular reconstruction using an axially vascularized tissue-engineered construct

    Directory of Open Access Journals (Sweden)

    Khalil Mohamed R

    2011-03-01

    Full Text Available Abstract Background Current reconstructive techniques for continuity defects of the mandible include the use of free flaps, bone grafts, and alloplastic materials. New methods of regenerative medicine designed to restore tissues depend mainly on the so-called extrinsic neovascularization, where the neovascular bed originates from the periphery of the construct. This method is not applicable for large defects in irradiated fields. Methods We are introducing a new animal model for mandibular reconstruction using intrinsic axial vascularization by the Arterio-Venous (AV loop. In order to test this model, we made cadaveric, mechanical loading, and surgical pilot studies on adult male goats. The cadaveric study aimed at defining the best vascular axis to be used in creating the AV loop in the mandibular region. Mechanical loading studies (3 points bending test were done to ensure that the mechanical properties of the mandible were significantly affected by the designed defect, and to put a base line for further mechanical testing after bone regeneration. A pilot surgical study was done to ensure smooth operative and post operative procedures. Results The best vascular axis to reconstruct defects in the posterior half of the mandible is the facial artery (average length 32.5 ± 1.9 mm, caliber 2.5 mm, and facial vein (average length 33.3 ± 1.8 mm, caliber 2.6 mm. Defects in the anterior half require an additional venous graft. The defect was shown to be significantly affecting the mechanical properties of the mandible (P value 0.0204. The animal was able to feed on soft diet from the 3rd postoperative day and returned to normal diet within a week. The mandible did not break during the period of follow up (2 months. Conclusions Our model introduces the concept of axial vascularization of mandibular constructs. This model can be used to assess bone regeneration for large bony defects in irradiated fields. This is the first study to introduce the

  20. Design and axial optimization of nuclear fuel for BWR reactors; Diseno y optimizacion axial de combustible nuclear para reactores BWR

    Energy Technology Data Exchange (ETDEWEB)

    Garcia V, M.A

    2006-07-01

    In the present thesis, the modifications made to the axial optimization system based on Tabu Search (BT) for the axial design of BWR fuel type are presented, developed previously in the Nuclear Engineering Group of the UNAM Engineering Faculty. With the modifications what is mainly looked is to consider the particular characteristics of the mechanical design of the GE12 fuel type, used at the moment in the Laguna Verde Nucleo electric Central (CNLV) and that it considers the fuel bars of partial longitude. The information obtained in this thesis will allow to plan nuclear fuel reloads with the best conditions to operate in a certain cycle guaranteeing a better yield and use in the fuel burnt, additionally people in charge in the reload planning will be favored with the changes carried out to the system for the design and axial optimization of nuclear fuel, which facilitate their handling and it reduces their execution time. This thesis this developed in five chapters that are understood in the following way in general: Chapter 1: It approaches the basic concepts of the nuclear energy, it describes the physical and chemical composition of the atoms as well as that of the uranium isotopes, the handling of the uranium isotope by means of the nuclear fission until arriving to the operation of the nuclear reactors. Chapter 2: The nuclear fuel cycle is described, the methods for its extraction, its conversion and its enrichment to arrive to the stages of the nuclear fuel management used in the reactors are described. Beginning by the radial design, the axial design and the core design of the nuclear reactor related with the fuel assemblies design. Chapter 3: the optimization methods of nuclear fuel previously used are exposed among those that are: the genetic algorithms method, the search methods based on heuristic rules and the application of the tabu search method, which was used for the development of this thesis. Chapter 4: In this part the used methodology to the

  1. Concept Maps

    OpenAIRE

    Schwendimann, Beat Adrian

    2014-01-01

    A concept map is a node-link diagram showing the semantic relationships among concepts. The technique for constructing concept maps is called "concept mapping". A concept map consists of nodes, arrows as linking lines, and linking phrases that describe the relationship between nodes. Two nodes connected with a labeled arrow are called a proposition. Concept maps are versatile graphic organizers that can represent many different forms of relationships between concepts. The relationship between...

  2. Process and apparatus for recovery from rotating stall in axial flow fans and compressors

    OpenAIRE

    1997-01-01

    Active recovery from a rotating stall operating condition in an axial flow compression system is accomplished by altering the temperature and/or density of the working fluid flowing in the inlet of the compression system once rotating stall is detected. A burner is used to increase the compressor inlet flow temperature and concomitantly reduce the inlet flow density. Alternatively, a low density gas such as helium is injected into the compressor inlet. The ingestion of high temperature gases ...

  3. Mastering Ninject for dependency injection

    CERN Document Server

    Baharestani, Daniel

    2013-01-01

    Mastering Ninject for Dependency Injection teaches you the most powerful concepts of Ninject in a simple and easy-to-understand format using lots of practical examples, diagrams, and illustrations.Mastering Ninject for Dependency Injection is aimed at software developers and architects who wish to create maintainable, extensible, testable, and loosely coupled applications. Since Ninject targets the .NET platform, this book is not suitable for software developers of other platforms. Being familiar with design patterns such as singleton or factory would be beneficial, but no knowledge of depende

  4. Flow Injection will be 25 years

    DEFF Research Database (Denmark)

    Hansen, Elo Harald

    1999-01-01

    The article is a brief review of the first 25 years of Flow Injection Analysis (FIA), that is, from its conception and early development in the mid-70'es at the Department of Chemistry at DTU, yet it is particularly discussing why this analytical concept has had the impact that the ensuing 10...

  5. Optimization of residual heat removal pump axial thrust and axial bearing

    Energy Technology Data Exchange (ETDEWEB)

    Schubert, F.

    1996-12-01

    The residual heat removal (RHR) pumps of German 1300 megawatt pressurized-water reactor (PWR) power plants are of the single stage end suction type with volute casing or with diffuser and forged circular casing. Due to the service conditions the pumps have to cover the full capacity range as well as a big variation in suction static pressure. This results in a big difference in the axial thrust that has to be borne by the axial bearing. Because these pumps are designed to operate without auxiliary systems (things that do not exist can not fail), they are equipped with antifriction bearings and sump oil lubrication. To minimize the heat production within the bearing casing, a number of PWR plants have pumps with combined axial/radial bearings of the ball type. Due to the fact that the maximum axial thrust caused by static pressure and hydrodynamic forces on the impeller is too big to be borne by that type of axial bearing, the impellers were designed to produce a hydrodynamic axial force that counteracts the static axial force. Thus, the resulting axial thrust may change direction when the static pressure varies.

  6. Reducing axial mixing in flotation columns

    Energy Technology Data Exchange (ETDEWEB)

    Al Taweel, A.M.; Ramadan, A.M. [Technical Univ. of Nova Scotia, Halifax (Canada). Chemical Engineering Dept.; Moharam, M.R.; Hassan, T.A. [Al Azhar Univ., Cairo (Egypt); El Mofty, S.M. [Cairo Univ., Giza (Egypt)

    1995-10-01

    The axial mixing characteristics of a pilot-scale flotation column were investigated with the objective of identifying means to mitigate the extent of axial mixing that adversely affects its grade/recovery performance. A wide range of design and operating conditions wa investigated and the experimental results, obtained using the dynamic response method, were analyzed using three axial mixing models. The dynamic response of the column can best be described using the axial dispersion model. The results obtained suggest that the value of the axial dispersion coefficient, E{sub L}, can be significantly reduced by judicial selection of hydrodynamic conditions and/or the use of column inserts that suppress the onset of hydrodynamic instabilities inherent to the operation of conventional flotation columns. Up to 40% reduction in the value of E{sub L} was thus obtained by using spargers that produce more uniform bubble sizes, while up to 30% reductions were obtained by controlling the residual frother concentration. 33 refs., 7 figs.

  7. Axial super-resolution evanescent wave tomography.

    Science.gov (United States)

    Pendharker, Sarang; Shende, Swapnali; Newman, Ward; Ogg, Stephen; Nazemifard, Neda; Jacob, Zubin

    2016-12-01

    Optical tomographic reconstruction of a three-dimensional (3D) nanoscale specimen is hindered by the axial diffraction limit, which is 2-3 times worse than the focal plane resolution. We propose and experimentally demonstrate an axial super-resolution evanescent wave tomography method that enables the use of regular evanescent wave microscopes like the total internal reflection fluorescence microscope beyond surface imaging and achieve a tomographic reconstruction with axial super-resolution. Our proposed method based on Fourier reconstruction achieves axial super-resolution by extracting information from multiple sets of 3D fluorescence images when the sample is illuminated by an evanescent wave. We propose a procedure to extract super-resolution features from the incremental penetration of an evanescent wave and support our theory by one-dimensional (along the optical axis) and 3D simulations. We validate our claims by experimentally demonstrating tomographic reconstruction of microtubules in HeLa cells with an axial resolution of ∼130  nm. Our method does not require any additional optical components or sample preparation. The proposed method can be combined with focal plane super-resolution techniques like stochastic optical reconstruction microscopy and can also be adapted for THz and microwave near-field tomography.

  8. Axial super-resolution evanescent wave tomography

    Science.gov (United States)

    Pendharker, Sarang; Shende, Swapnali; Newman, Ward; Ogg, Stephen; Nazemifard, Neda; Jacob, Zubin

    2016-12-01

    Optical tomographic reconstruction of a 3D nanoscale specimen is hindered by the axial diffraction limit, which is 2-3 times worse than the focal plane resolution. We propose and experimentally demonstrate an axial super-resolution evanescent wave tomography (AxSET) method that enables the use of regular evanescent wave microscopes like Total Internal Reflection Fluorescence Microscope (TIRF) beyond surface imaging, and achieve tomographic reconstruction with axial super-resolution. Our proposed method based on Fourier reconstruction achieves axial super-resolution by extracting information from multiple sets of three-dimensional fluorescence images when the sample is illuminated by an evanescent wave. We propose a procedure to extract super-resolution features from the incremental penetration of an evanescent wave and support our theory by 1D (along the optical axis) and 3D simulations. We validate our claims by experimentally demonstrating tomographic reconstruction of microtubules in HeLa cells with an axial resolution of $\\sim$130 nm. Our method does not require any additional optical components or sample preparation. The proposed method can be combined with focal plane super-resolution techniques like STORM and can also be adapted for THz and microwave near-field tomography.

  9. Atlanto-axial infection after acupuncture.

    Science.gov (United States)

    Robinson, A; Lind, C R P; Smith, R J; Kodali, V

    2015-12-11

    A 67-year-old man presented with neck cellulitis following acupuncture for cervical spondylosis. Blood cultures were positive for methicillin-sensitive Staphylococcus aureus. Increased neck pain and bacteraemia prompted MRI, which showed atlanto-axial septic arthritis without signs of infection of the tissues between the superficial cellulitic area and the atlanto-axial joint, thus making direct extension of infection unlikely. It is more likely that haematogenous spread of infection resulted in seeding in the atlanto-axial joint, with the proximity of the arthritis and acupuncture site being coincidental. Acupuncture is a treatment option for some indolent pain conditions. As such, acupuncture services are likely to be more frequently utilised. A history of acupuncture is rarely requested by the admitting doctor and seldom offered voluntarily by the patient, especially where the site of infection due to haematogenous spread is distant from the needling location. Awareness of infectious complications following acupuncture can reduce morbidity through early intervention.

  10. Axial symmetry and conformal Killing vectors

    CERN Document Server

    Mars, M; Mars, Marc; Senovilla, Jose M.M.

    1993-01-01

    Axisymmetric spacetimes with a conformal symmetry are studied and it is shown that, if there is no further conformal symmetry, the axial Killing vector and the conformal Killing vector must commute. As a direct consequence, in conformally stationary and axisymmetric spacetimes, no restriction is made by assuming that the axial symmetry and the conformal timelike symmetry commute. Furthermore, we prove that in axisymmetric spacetimes with another symmetry (such as stationary and axisymmetric or cylindrically symmetric spacetimes) and a conformal symmetry, the commutator of the axial Killing vector with the two others mush vanish or else the symmetry is larger than that originally considered. The results are completely general and do not depend on Einstein's equations or any particular matter content.

  11. Axial flow positive displacement worm gas generator

    Science.gov (United States)

    Murrow, Kurt David (Inventor); Giffin, Rollin George (Inventor); Fakunle, Oladapo (Inventor)

    2010-01-01

    An axial flow positive displacement engine has an inlet axially spaced apart and upstream from an outlet. Inner and outer bodies have offset inner and outer axes extend from the inlet to the outlet through first, second, and third sections of a core assembly in serial downstream flow relationship. At least one of the bodies is rotatable about its axis. The inner and outer bodies have intermeshed inner and outer helical blades wound about the inner and outer axes respectively. The inner and outer helical blades extend radially outwardly and inwardly respectively. The helical blades have first, second, and third twist slopes in the first, second, and third sections respectively. The first twist slopes are less than the second twist slopes and the third twist slopes are less than the second twist slopes. A combustor section extends axially downstream through at least a portion of the second section.

  12. Improving the lattice axial vector current

    Energy Technology Data Exchange (ETDEWEB)

    Horsley, R. [Edinburgh Univ. (United Kingdom). School of Physics and Astronomy; Nakamura, Y. [RIKEN Advanced Institute for Computational Science, Kobe (Japan); Perlt, H.; Schiller, A. [Leipzig Univ. (Germany). Inst. fuer Theoretische Physik; Rakow, P.E.L. [Liverpool Univ. (United Kingdom). Theoretical Physics Div.; Schierholz, G. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Zanotti, J.M. [Adelaide Univ. (Australia). CSSM, Dept. of Physics

    2015-11-15

    For Wilson and clover fermions traditional formulations of the axial vector current do not respect the continuum Ward identity which relates the divergence of that current to the pseudoscalar density. Here we propose to use a point-split or one-link axial vector current whose divergence exactly satisfies a lattice Ward identity, involving the pseudoscalar density and a number of irrelevant operators. We check in one-loop lattice perturbation theory with SLiNC fermion and gauge plaquette action that this is indeed the case including order O(a) effects. Including these operators the axial Ward identity remains renormalisation invariant. First preliminary results of a nonperturbative check of the Ward identity are also presented.

  13. Organocatalytic atroposelective synthesis of axially chiral styrenes

    Science.gov (United States)

    Zheng, Sheng-Cai; Wu, San; Zhou, Qinghai; Chung, Lung Wa; Ye, Liu; Tan, Bin

    2017-05-01

    Axially chiral compounds are widespread in biologically active compounds and are useful chiral ligands or organocatalysts in asymmetric catalysis. It is well-known that styrenes are one of the most abundant and principal feedstocks and thus represent excellent prospective building blocks for chemical synthesis. Driven by the development of atroposelective synthesis of axially chiral styrene derivatives, we discovered herein the asymmetric organocatalytic approach via direct Michael addition reaction of substituted diones/ketone esters/malononitrile to alkynals. The axially chiral styrene compounds were produced with good chemical yields, enantioselectivities and almost complete E/Z-selectivities through a secondary amine-catalysed iminium activation strategy under mild conditions. Such structural motifs are important precursors for further transformations into biologically active compounds and synthetic useful intermediates and may have potential applications in asymmetric synthesis as olefin ligands or organocatalysts.

  14. Improving the lattice axial vector current

    CERN Document Server

    Horsley, R; Perlt, H; Rakow, P E L; Schierholz, G; Schiller, A; Zanotti, J M

    2015-01-01

    For Wilson and clover fermions traditional formulations of the axial vector current do not respect the continuum Ward identity which relates the divergence of that current to the pseudoscalar density. Here we propose to use a point-split or one-link axial vector current whose divergence exactly satisfies a lattice Ward identity, involving the pseudoscalar density and a number of irrelevant operators. We check in one-loop lattice perturbation theory with SLiNC fermion and gauge plaquette action that this is indeed the case including order $O(a)$ effects. Including these operators the axial Ward identity remains renormalisation invariant. First preliminary results of a nonperturbative check of the Ward identity are also presented.

  15. Application of Nonlocal Elasticity Shell Model for Axial Buckling of Single-Walled Carbon Nanotubes

    Directory of Open Access Journals (Sweden)

    Farzad Khademolhosseini

    2009-10-01

    Full Text Available Recently, nano devices have been developed which use Carbon Nanotubes (CNTs as structural elements. To define the range of applicability of CNTs in such devices, it is important to investigate failure modes such as the axial buckling limit. Classical continuum models are inaccurate as they are unable to account for the size-effects in such devices. In this work, a modified nonlocal continuum shell model for the axial buckling of CNTs is proposed and compared with a nonlocal model for torsional buckling. This is done through modifying classical continuum models by incorporating basic concepts from nonlocal elasticity. Furthermore, molecular dynamics (MD simulations are performed on a range of nanotubes with different diameters. Compared to classical models, the modified nonlocal models provide a much better fit to MD simulation results. Using MD simulation results for axial buckling, values of the nonlocal constant and shell thickness are calculated.

  16. Axial loaded MRI of the lumbar spine

    Energy Technology Data Exchange (ETDEWEB)

    Saifuddin, A. E-mail: asaifuddin@aol.com; Blease, S.; MacSweeney, E

    2003-09-01

    Magnetic resonance imaging is established as the technique of choice for assessment of degenerative disorders of the lumbar spine. However, it is routinely performed with the patient supine and the hips and knees flexed. The absence of axial loading and lumbar extension results in a maximization of spinal canal dimensions, which may in some cases, result in failure to demonstrate nerve root compression. Attempts have been made to image the lumbar spine in a more physiological state, either by imaging with flexion-extension, in the erect position or by using axial loading. This article reviews the literature relating to the above techniques.

  17. Water Ingestion Into Axial Flow Compressors

    Science.gov (United States)

    1976-08-01

    AFAPL-TR-76-77 WATER INGESTION INTO AXIAL FLOW COMPRESSORS PURDUE UNIVERSITY SCHOOL OF AERONAUTICS AND ASTRONA UTICS S WEST LAFAYETTE, INDIANA 47907...CIPIENT’S CATALOG NUMBER TITL _07" 0 EREO Final i-7 0 Water Ingestion Into Axial Flow Compressorse 1 Auq 75 -: 31 Au0 a6 114o’ H-WPAFB-T-76-l:P ."CO TACT...necessary and Idenify by block number) Water ingestion , turbomachinery, and jet engines. 20 ABSTRACT (Contlinue on tov.ras side Hi necessary and Identify

  18. Optimization of Axial Intensity Point Spread Function

    Institute of Scientific and Technical Information of China (English)

    WANG Haifeng; GAN Fuxi; CHEN Zhongyu

    2001-01-01

    It is known that for the converged laser beam, the axial intensity distribution corresponds to a Gaussian curve, that is, the intensity on the focal plane is the peak intensity. When it defocuses, the intensity would decrease rapidly. In optical data storage, for instance, we expect the intensity within a certain distance to be almost equal. In this paper, we propose to use a pure phase superresolution apodizer to optimize the axial intensity distribution of the converged laser beam and at the same time improve the resolution. The intensity point spread function remains almost identical in a wide range within the focal depth.

  19. Axial Nucleon form factors from lattice QCD

    CERN Document Server

    Alexandrou, C; Carbonell, J; Constantinou, M; Harraud, P A; Guichon, P; Jansen, K; Korzec, T; Papinutto, M

    2010-01-01

    We present results on the nucleon axial form factors within lattice QCD using two flavors of degenerate twisted mass fermions. Volume effects are examined using simulations at two volumes of spatial length $L=2.1$ fm and $L=2.8$ fm. Cut-off effects are investigated using three different values of the lattice spacings, namely $a=0.089$ fm, $a=0.070$ fm and $a=0.056$ fm. The nucleon axial charge is obtained in the continuum limit and chirally extrapolated to the physical pion mass enabling comparison with experiment.

  20. Axial Vircator for Electronic Warfare Applications

    Directory of Open Access Journals (Sweden)

    L. Drazan

    2009-12-01

    Full Text Available This paper deals with a high power microwave generator with virtual cathode – vircator in axial release for electronic warfare applications. The classification of directed energy weapons microwave (DEWM is introduced together with basic block diagrams of a particular class of DEWM. In the paper, methods for designing vircator pulsed power supply, axial vircator structure, measurement methods and experimental results are presented. The vircator in electromagnetic ammunition is powered by magneto-cumulative generator and in weapons for defense of objects (WDO, it is powered by Marx generator. The possible applications of a vircator in the DEWM area are discussed.

  1. Scalar Resonances in Axially Symmetric Spacetimes

    CERN Document Server

    Ranea-Sandoval, Ignacio F

    2015-01-01

    We study properties of resonant solutions to the scalar wave equation in several axially symmetric spacetimes. We prove that non-axial resonant modes do not exist neither in the Lanczos dust cylinder, the $(2+1)$ extreme BTZ spacetime nor in a class of simple rotating wormhole solutions. Moreover, we find unstable solutions to the wave equation in the Lanczos dust cylinder and in the $r^2 <0$ region of the extreme $(2+1)$ BTZ spacetime, two solutions that possess closed timelike curves. Similarities with previous results obtained for the Kerr spacetime are explored.

  2. Taylor-Couette flow with radial fluid injection

    Science.gov (United States)

    Wilkinson, Nikolas; Dutcher, Cari S.

    2017-08-01

    Taylor-Couette cells have been shown to improve a number of industrial processes due to the wide variety of hydrodynamic flow states accessible. Traditional designs, however, limit the ability to introduce new fluids into the annulus during device operation due to geometric confinement and complexity. In this paper, a co- and counter-rotating Taylor-Couette cell with radial fluid injection has been constructed. The incorporation of 16 ports in the inner cylinder enables radial fluid injection during rotation of both cylinders. The design is also capable of continuous axial flow, enabling large injection volumes. The new inner cylinder design does not modify the critical Re for flow instabilities and can precisely inject a desired mass at a desired flow rate. A range of injection rates and masses were explored to quantify the effect of radial injection on the stability of the turbulent Taylor vortex structure. Only the highest injection rate and total mass studied (5.9 g/s, 100 g) modified the turbulent Taylor vortex structure after injection for a sustained period. The post-injection vortices remained larger than the pre-injection vortices, whereas at lower injection rates or masses, the vortex structure quickly returned to the pre-injection structure. This new system allows for in situ study of hydrodynamic effects on fluid-fluid (gas and liquid) mixing and multiphase complexation, growth, and structure. We demonstrated this new design's potential for studying the flocculation of bentonite using cationic polyacrylamide for enhancing water treatment operations.

  3. Penicillin G Procaine Injection

    Science.gov (United States)

    Penicillin G procaine injection is used to treat certain infections caused by bacteria. Penicillin G procaine injection should not be used to treat ... in the treatment of certain serious infections. Penicillin G procaine injection is in a class of medications ...

  4. Excitation modes in non-axial nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Leviatan, A.; Ginnochio, J.N.

    1990-01-01

    Excitation modes of non-axial quadrupole shapes are investigated in the framework of interacting boson models. Both {gamma}-unstable and {gamma}-rigid nuclear shapes are considered for systems with one type of boson as well as with proton-neutron bosons. 6 refs.

  5. Cystic lesions accompanying extra-axial tumours

    NARCIS (Netherlands)

    Lohle, PNM; Wurzer, HAL; Seelen, PJ; Kingma, LM; Go, KG

    1999-01-01

    We examined the mechanism of cyst formation in extra-axial tumours in the central nervous system (CNS). Cyst fluid, cerebrospinal fluid (CSF) and blood plasma were analysed in eight patients with nine peritumoral cysts: four with meningiomas, two with intracranial and two spinal intradural schwannom

  6. Knowledge Based Design of Axial Flow Compressor

    Directory of Open Access Journals (Sweden)

    Dinesh kumar.R

    2015-05-01

    Full Text Available In the aerospace industry with highly competitive market the time to design and delivery is shortening every day. Pressure on delivering robust product with cost economy is in demand in each development. Even though technology is older, it is new for each customer requirement and highly non-liner to fit one in another place. Gas turbine is considered one of a complex design in the aircraft system. It involves experts to be grouped with designers of various segments to arrive the best output. The time is crucial to achieve a best design and it needs knowledge automation incorporated with CAD/CAE tools. In the present work an innovative idea in the form of Knowledge Based Engineering for axial compressor is proposed, this includes the fundamental design of axial compressor integrated with artificial intelligence in the form of knowledge capturing and programmed with high level language (Visual Basis.Net and embedded into CATIA v5. This KBE frame work eases out the design and modeling of axial compressor design and produces 3D modeling for further flow simulation with fluid dynamic in Ansys-Fluent. Most of the aerospace components are developed through simulation driven product development and in this case it is established for axial compressor.

  7. Active axial stress in mouse aorta.

    Science.gov (United States)

    Agianniotis, A; Rachev, A; Stergiopulos, N

    2012-07-26

    The study verifies the development of active axial stress in the wall of mouse aorta over a range of physiological loads when the smooth muscle cells are stimulated to contract. The results obtained show that the active axial stress is virtually independent of the magnitude of pressure, but depends predominately on the longitudinal stretch ratio. The dependence is non-monotonic and is similar to the active stress-stretch dependence in the circumferential direction reported in the literature. The expression for the active axial stress fitted to the experimental data shows that the maximum active stress is developed at longitudinal stretch ratio 1.81, and 1.56 is the longitudinal stretch ratio below which the stimulation does not generate active stress. The study shows that the magnitude of active axial stress is smaller than the active circumferential stress. There is need for more experimental investigations on the active response of different types of arteries from different species and pathological conditions. The results of these studies can promote building of refined constrictive models in vascular rheology. Copyright © 2012 Elsevier Ltd. All rights reserved.

  8. Investigations on Experimental Impellers for Axial Blowers

    Science.gov (United States)

    Encke, W.

    1947-01-01

    A selection of measurements obtained on experimental impellers for axial blowers will be reported. In addition to characteristic curves plotted for low and for high peripheral velocities, proportions and blade sections for six different blower models and remarks on the design of blowers will be presented.

  9. Wave propagation in axially moving periodic strings

    DEFF Research Database (Denmark)

    Sorokin, Vladislav S.; Thomsen, Jon Juel

    2017-01-01

    The paper deals with analytically studying transverse waves propagation in an axially moving string with periodically modulated cross section. The structure effectively models various relevant technological systems, e.g. belts, thread lines, band saws, etc., and, in particular, roller chain drive...

  10. Epidural steroid injection for lumbosacral radiculopathy

    Energy Technology Data Exchange (ETDEWEB)

    Sung, Mi Sook [The Catholic University of Korea, Pucheon (Korea, Republic of)

    2006-06-15

    Low back pain combined with radicular pain remains as one of the most challenging musculoskeletal problems for its therapeutic management. This malady results from nerve root impingement and/or inflammation that causes neurologic symptoms in the distribution of the affected nerve root(s) Conservative treatment, percutaneous spine interventions and surgery have all been used as treatment; and the particular treatment that's chosen depends on the severity of the clinical and neurologic presentation. In 1930, Evans reported that sciatica could treated by epidural injection. The use of epidural corticosteroid injections for the treatment of axial and radicular back pain was first reported in 1953. Epidural steroid injections are currently used by many medical professionals for the treatment of lumbosacral radiculopathy. Performing 'blind' epidural steroid injection lacks target specificity that often results in incorrect delivery of medication to the lesion. Imaging-guided steroid injections are now becoming more popular despite the controversy regarding their efficacy. Many reports, including a few randomized controlled trials, have documented the clinical utility of epidural steroid injections.

  11. Iron Dextran Injection

    Science.gov (United States)

    ... allergic to iron dextran injection; any other iron injections such as ferric carboxymaltose (Injectafer), ferumoxytol (Feraheme), iron sucrose (Venofer), or sodium ferric gluconate (Ferrlecit);any other ...

  12. Might axial myofascial properties and biomechanical mechanisms be relevant to ankylosing spondylitis and axial spondyloarthritis?

    OpenAIRE

    Masi, Alfonse T.

    2014-01-01

    Ankylosing spondylitis and axial spondyloarthropathy have characteristic age- and sex-specific onset patterns, typical entheseal lesions, and marked heritability, but the integrative mechanisms causing the pathophysiological and structural alterations remain largely undefined. Myofascial tissues are integrated in the body into webs and networks which permit transmission of passive and active tensional forces that provide stabilizing support and help to control movements. Axial myofascial hype...

  13. Might axial myofascial properties and biomechanical mechanisms be relevant to ankylosing spondylitis and axial spondyloarthritis?

    OpenAIRE

    Masi, Alfonse T.

    2014-01-01

    Ankylosing spondylitis and axial spondyloarthropathy have characteristic age- and sex-specific onset patterns, typical entheseal lesions, and marked heritability, but the integrative mechanisms causing the pathophysiological and structural alterations remain largely undefined. Myofascial tissues are integrated in the body into webs and networks which permit transmission of passive and active tensional forces that provide stabilizing support and help to control movements. Axial myofascial hype...

  14. The Kenya rift axial gravity high: a re-interpretation

    Science.gov (United States)

    Swain, C. J.

    1992-03-01

    Since KRISP 85 did not provide overwhelming evidence for the massive intrusion that was originally suggested to explain the axial gravity high yet did provide a velocity section for the upper crust along the axis of the Kenya Rift, it is appropriate to use this section to control a re-interpretation of the gravity anomalies. A 2 {1}/{2} D inversion procedure has been used to model a number of isostatic anomaly profiles between Lake Baringo and Suswa. There are too many unknowns and gravity station coverage is too sparse for the results to be unique. Nevertheless, certain conclusions can be drawn. One of those is that some relatively dense material exists within the basement all along the Rift axis, since the axial isostatic anomalies are positive even though they occur where there are several thousand metres of Cenozoic volcanics of relatively low density (inferred from their seismic velocity of 3.7-5.1 km/s). The dense material is envisaged as a zone of dyke injection and assigned a density of 2.75-2.76 g/cm 3 (corresponding to its 6.05 km/s velocity) compared to a normal basement density of 2.70 g/cm 3. It is assumed to extend down to 22 km—the top of the 7.1 km/s layer. The KRISP 85 line passed just east of Menengai, where the basement velocity increases to about 6.6 km/s over a distance of about 20 km. On an east-west gravity profile through Menengai there is a gravity high corresponding to this velocity increase which has been modelled as a basic intrusion (density 2.93 g/cm 3) underlying the caldera.

  15. Concepts of formal concept analysis

    Science.gov (United States)

    Žáček, Martin; Homola, Dan; Miarka, Rostislav

    2017-07-01

    The aim of this article is apply of Formal Concept Analysis on concept of world. Formal concept analysis (FCA) as a methodology of data analysis, information management and knowledge representation has potential to be applied to a verity of linguistic problems. FCA is mathematical theory for concepts and concept hierarchies that reflects an understanding of concept. Formal concept analysis explicitly formalizes extension and intension of a concept, their mutual relationships. A distinguishing feature of FCA is an inherent integration of three components of conceptual processing of data and knowledge, namely, the discovery and reasoning with concepts in data, discovery and reasoning with dependencies in data, and visualization of data, concepts, and dependencies with folding/unfolding capabilities.

  16. Sipuleucel-T Injection

    Science.gov (United States)

    Sipuleucel-T injection is used to treat certain types of advanced prostate cancer. Sipuleucel-T injection is in a class of medications called ... Sipuleucel-T injection comes as a suspension (liquid) to be injected over about 60 minutes into a vein ...

  17. Piping inspection carriage having axially displaceable sensor

    Science.gov (United States)

    Zollinger, William T.; Treanor, Richard C.

    1994-01-01

    A pipe inspection instrument carriage for use with a pipe crawler for performing internal inspections of piping surfaces. The carriage has a front leg assembly, a rear leg assembly and a central support connecting the two assemblies and for mounting an instrument arm having inspection instruments. The instrument arm has a y-arm mounted distally thereon for axially aligning the inspection instrumentation and a mounting block, a linear actuator and axial movement arm for extending the inspection instruments radially outward to operably position the inspection instruments on the piping interior. Also, the carriage has a rotation motor and gear assembly for rotating the central support and the front leg assembly with respect to the rear leg assembly so that the inspection instruments azimuthally scan the piping interior. The instrument carriage allows performance of all piping inspection operations with a minimum of moving parts, thus decreasing the likelihood of performance failure.

  18. Direct optical nanoscopy with axially localized detection

    CERN Document Server

    Bourg, N; Dupuis, G; Barroca, T; Bon, P; Lécart, S; Fort, E; Lévêque-Fort, S

    2014-01-01

    Evanescent light excitation is widely used in super-resolution fluorescence microscopy to confine light and reduce background noise. Herein we propose a method of exploiting evanescent light in the context of emission. When a fluorophore is located in close proximity to a medium with a higher refractive index, its near-field component is converted into light that propagates beyond the critical angle. This so-called Supercritical Angle Fluorescence (SAF) can be captured using a hig-NA objective and used to determine the axial position of the fluorophore with nanometer precision. We introduce a new technique for 3D nanoscopy that combines direct STochastic Optical Reconstruction Microscopy (dSTORM) imaging with dedicated detection of SAF emission. We demonstrate that our approach of a Direct Optical Nanoscopy with Axially Localized Detection (DONALD) yields a typical isotropic 3D localization precision of 20 nm.

  19. Axial flow positive displacement worm compressor

    Science.gov (United States)

    Murrow, Kurt David (Inventor); Giffin, Rollin George (Inventor); Fakunle, Oladapo (Inventor)

    2010-01-01

    An axial flow positive displacement compressor has an inlet axially spaced apart and upstream from an outlet. Inner and outer bodies have offset inner and outer axes extend from the inlet to the outlet through first and second sections of a compressor assembly in serial downstream flow relationship. At least one of the bodies is rotatable about its axis. The inner and outer bodies have intermeshed inner and outer helical blades wound about the inner and outer axes respectively. The inner and outer helical blades extend radially outwardly and inwardly respectively. The helical blades have first and second twist slopes in the first and second sections respectively. The first twist slopes are less than the second twist slopes. An engine including the compressor has in downstream serial flow relationship from the compressor a combustor and a high pressure turbine drivingly connected to the compressor by a high pressure shaft.

  20. Matrix calculus for axially symmetric polarized beam.

    Science.gov (United States)

    Matsuo, Shigeki

    2011-06-20

    The Jones calculus is a well known method for analyzing the polarization of a fully polarized beam. It deals with a beam having spatially homogeneous polarization. In recent years, axially symmetric polarized beams, where the polarization is not homogeneous in its cross section, have attracted great interest. In the present article, we show the formula for the rotation of beams and optical elements on the angularly variant term-added Jones calculus, which is required for analyzing axially symmetric beams. In addition, we introduce an extension of the Jones calculus: use of the polar coordinate basis. With this calculus, the representation of some angularly variant beams and optical elements are simplified and become intuitive. We show definitions, examples, and conversion formulas between different notations.

  1. Consistent formulation of the spacelike axial gauge

    Energy Technology Data Exchange (ETDEWEB)

    Burnel, A.; Van der Rest-Jaspers, M.

    1983-12-15

    The usual formulation of the spacelike axial gauge is afflicted with the difficulty that the metric is indefinite while no ghost is involved. We solve this difficulty by introducing a ghost whose elimination is such that the metric becomes positive for physical states. The technique consists in the replacement of the gauge condition nxA = 0 by the weaker one partial/sub 0/nxAroughly-equal0.

  2. Transonic Axial Splittered Rotor Tandem Stator Stage

    Science.gov (United States)

    2016-12-01

    compressor rotor was designed incorporating a splitter vane between the principal blades . Historical experiments conducted by Dr. Arthur J...conventional rotor design . The stage is composed of the rotor and stator. The flow of the air passing through the rotor is turned, and the flow is required...derived results achieved the best blade geometry for design continuation. The best circumferential and axial placement for the splitter blade was

  3. Multimode interaction in axially excited cylindrical shells

    OpenAIRE

    2014-01-01

    Cylindrical shells exhibit a dense frequency spectrum, especially near the lowest frequency range. In addition, due to the circumferential symmetry, frequencies occur in pairs. So, in the vicinity of the lowest natural frequencies, several equal or nearly equal frequencies may occur, leading to a complex dynamic behavior. So, the aim of the present work is to investigate the dynamic behavior and stability of cylindrical shells under axial forcing with multiple equal or nearly equal natural fr...

  4. Axial flux permanent magnet brushless machines

    CERN Document Server

    Gieras, Jacek F; Kamper, Maarten J

    2008-01-01

    Axial Flux Permanent Magnet (AFPM) brushless machines are modern electrical machines with a lot of advantages over their conventional counterparts. They are being increasingly used in consumer electronics, public life, instrumentation and automation system, clinical engineering, industrial electromechanical drives, automobile manufacturing industry, electric and hybrid electric vehicles, marine vessels and toys. They are also used in more electric aircrafts and many other applications on larger scale. New applications have also emerged in distributed generation systems (wind turbine generators

  5. Enhancement of Optical Coherence Tomography Axial Resolution by Spectral Shaping

    Institute of Scientific and Technical Information of China (English)

    孙汕; 郭继华; 高湔松; 薛平

    2002-01-01

    We propose a new method of changing the spectrum shape to improve the axial resolution of optical coherencetomography (OCT). Theoretical analysis shows that certain spectral shaping can shorten the coherence length.Comparisons of the simulation and experimental measurements of spectral shape and axial resolution of OCTare given, showing that the axial resolution of OCT is enhanced by a factor of 1.4.

  6. Direct optical nanoscopy with axially localized detection

    Science.gov (United States)

    Bourg, N.; Mayet, C.; Dupuis, G.; Barroca, T.; Bon, P.; Lécart, S.; Fort, E.; Lévêque-Fort, S.

    2015-09-01

    Evanescent light excitation is widely used in super-resolution fluorescence microscopy to confine light and reduce background noise. Here, we propose a method of exploiting evanescent light in the context of emission. When a fluorophore is located in close proximity to a medium with a higher refractive index, its near-field component is converted into light that propagates beyond the critical angle. This so-called supercritical-angle fluorescence can be captured using a high-numerical-aperture objective and used to determine the axial position of the fluorophore with nanometre precision. We introduce a new technique for three-dimensional nanoscopy that combines direct stochastic optical reconstruction microscopy (dSTORM) with dedicated detection of supercritical-angle fluorescence emission. We demonstrate that our approach of direct optical nanoscopy with axially localized detection (DONALD) typically yields an isotropic three-dimensional localization precision of 20 nm within an axial range of ∼150 nm above the coverslip.

  7. Axial gravity, massless fermions and trace anomalies

    Science.gov (United States)

    Bonora, L.; Cvitan, M.; Prester, P. Dominis; Pereira, A. Duarte; Giaccari, S.; Štemberga, T.

    2017-08-01

    This article deals with two main topics. One is odd parity trace anomalies in Weyl fermion theories in a 4d curved background, the second is the introduction of axial gravity. The motivation for reconsidering the former is to clarify the theoretical background underlying the approach and complete the calculation of the anomaly. The reference is in particular to the difference between Weyl and massless Majorana fermions and to the possible contributions from tadpole and seagull terms in the Feynman diagram approach. A first, basic, result of this paper is that a more thorough treatment, taking account of such additional terms and using dimensional regularization, confirms the earlier result. The introduction of an axial symmetric tensor besides the usual gravitational metric is instrumental to a different derivation of the same result using Dirac fermions, which are coupled not only to the usual metric but also to the additional axial tensor. The action of Majorana and Weyl fermions can be obtained in two different limits of such a general configuration. The results obtained in this way confirm the previously obtained ones.

  8. Golimumab for the treatment of axial spondyloarthritis.

    Science.gov (United States)

    Gelfer, Gita; Perry, Lisa; Deodhar, Atul

    2016-01-01

    Axial spondyloarthritis (axSpA) is a chronic, immune-mediated inflammatory disease of the axial skeleton that includes ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA). Patients with AS experience chronic pain due to sacroiliac joint and spinal inflammation, and may develop spinal ankylosing with syndesmophyte formation. Tumor necrosis factor α inhibitors (TNFi) have shown promise in the management of AS and axSpA by targeting the underlying inflammatory process, and providing symptomatic relief. Whether they alter the progression of the disease is uncertain. Golimumab is a fully human IgG1 monoclonal antibody that targets and downregulates the pro-inflammatory cytokine TNF-α. The use of golimumab has been shown to reduce the signs and symptoms of axSpA as well as improve patient function and quality reported outcomes. This review focuses on the biological rationale and the results of clinical trials with golimumab for the treatment of axSpA.

  9. Dynamic control of knee axial deformities

    Directory of Open Access Journals (Sweden)

    E. E. Malyshev

    2013-01-01

    Full Text Available The authors have evaluated the clinical examination of the patients with axial malalignments in the knee by the original method and device which was named varovalgometer. The measurements were conducted by tension of the cord through the spina iliaca anterior superior and the middle of the lower pole of patella. The deviation of the center of the ankle estimated by metal ruler which was positioned perpendicular to the lower leg axis on the level of the ankle joint line. The results of comparison of our method and computer navigation in 53 patients during the TKA show no statistically significant varieties but they differ by average 5° of valgus in clinical examination in comparison with mechanical axis which was identified by computer navigation. The dynamic control of axial malalignment can be used in clinical practice for estimation of the results of treatment of pathology with axial deformities in the knee; for the control of reduction and secondary displacement of the fractures around the knee; for assessment of instability; in planning of correctional osteotomies and intraoperative control of deformity correction; for estimation of Q angle in subluxation and recurrent dislocation of patella; in planning of TKA; during the growth of child it allows to assess the progression of deformity.

  10. Normative segment-specific axial and coronal angulation corridors of subaxial cervical column in axial rotation.

    Science.gov (United States)

    Yoganandan, Narayan; Stemper, Brian D; Pintar, Frank A; Baisden, Jamie L; Shender, Barry S; Paskoff, Glenn

    2008-03-01

    In contrast to clinical studies wherein loading magnitudes are indeterminate, experiments permit controlled and quantifiable moment applications, record kinematics in multiple planes, and allow derivation of moment-angulation corridors. Axial and coronal moment-angulation corridors were determined at every level of the subaxial cervical spine, expressed as logarithmic functions, and level-specificity of range of motion and neutral zones were evaluated. segmental primary axial and coupled coronal motions do not vary by level. Although it is known that cervical spine responses are coupled, segment-specific corridors of axial and coronal kinematics under axial twisting moments from healthy normal spines are not reported. Ten human cadaver columns (23-44 years, mean: 34 +/- 6.8) were fixed at the ends and targets were inserted to each vertebra to obtain kinematics in axial and coronal planes. The columns were subjected to pure axial twisting moments. Range of motion and neutral zone for primary-axial and coupled-coronal rotation components were determined at each spinal level. Data were analyzed using factorial analysis of variance. Moment-rotation angulations were expressed using logarithmic functions, and mean +/-1 standard deviation corridors were derived at each level for both components. Moment-angulations responses were nonlinear. Each segmental curve for both components was well represented by a logarithmic function (r2 > 0.95). Factorial analysis of variance indicated that the biomechanical metrics are spinal level-specific (P specific responses. The presentation of moment-angulation corridors for both metrics forms a dataset for the normal population. These segment-specific nonlinear corridors may help clinicians assess dysfunction or instability. These data will assist mathematical models of the spine in improved validation and lead to efficacious design of stabilizing systems.

  11. Classification criteria for psoriatic arthritis and ankylosing spondylitis/axial spondyloarthritis.

    Science.gov (United States)

    Rudwaleit, Martin; Taylor, William J

    2010-10-01

    The concept of spondyloarthritides (or spondyloarthropathies, SpAs) that comprises a group of interrelated disorders has been recognised since the early 1970s. While the European Spondyloarthropathy Study Group (ESSG) criteria and the Amor criteria have been developed to embrace the entire group of SpAs, new criteria for psoriatic arthritis have been developed recently. The Classification of Psoriatic Arthritis (CASPAR) study, a large one of more than 1000 patients, led to a new set of validated classification criteria for psoriatic arthritis. Since their publication in 2006 the CASPAR criteria are widely used in clinical studies. In ankylosing spondylitis, the 1984 modified New York criteria have been used widely in clinical studies and daily practice but are not applicable in early disease when the characteristic radiographical signs of sacroiliitis are not visible but active sacroiliitis is readily detectable by magnetic resonance imaging (MRI). This led to the concept of axial SpA that includes patients with and without radiographical damage; candidate criteria for axial SpA were developed based on proposals for a structured diagnostic approach. These criteria were validated in the Assessment of Spondyloarthritis International Society (ASAS) study on new classification criteria for axial SpA, a large international prospective study. In this new criteria, sacroiliitis showing up on MRI has been given as much weight as sacroiliitis on radiographs, thereby also identifying patients with early axial SpA. Both the CASPAR and the ASAS criteria for axial SpA are likely to be of use as diagnostic criteria.

  12. Combined therapeutic approach: Inflammatory bowel diseases and peripheral or axial arthritis

    Institute of Scientific and Technical Information of China (English)

    Fabiola Atzeni; Sandro Ardizzone; Luca Bertani; Marco Antivalle; Alberto Batticciotto; Piercarlo Sarzi-Puttini

    2009-01-01

    Inflammatory bowel diseases (IBDs), particularly Crohn's disease(CD) and ulcerative colitis(UC), are associated with a variety of extra-intestinal manifestations (EIMs). About 36% of IBD patients have at least one EIM, which most frequently affect the joints,skin, eyes and the biliary tract. The EIMs associated with IBD have a negative impact on patients with UC and CD, and the resolution of most of them parallels that of the active IBD in terms of timing and required therapy; however, the clinical course of EIMs such as axial arthritis, pyoderma gangrenosum, uveitis, and primary sclerosing cholangitis is independent of IBD activity. The peripheral and axial arthritis associated with IBD have traditionally been treated with simple analgesics, non-steroidal anti-inflammatory drugs,steroids, sulfasalazine, methotrexate, local steroid injections and physiotherapy, but the introduction of biological response modifiers such as tumor necrosis factor-α blockers, has led to further improvements.

  13. Effects of Axial Non-uniform Tip Clearances on Aerodynamic Performance of a Transonic Axial Compressor

    Institute of Scientific and Technical Information of China (English)

    Hongwei MA; Baihe LI

    2008-01-01

    This paper presents a numerical investigation of effects of axial non-uniform tip clearances on the aerodynamic performance of a transonic axial compressor rotor (NASA Rotor 37). The three-dimensional steady flow field within the rotor passage was simulated with the datum tip clearance of 0.356 mm at the design wheel speed of 17188.7 rpm. The simulation results are well consistent with the measurement results, which verified the numeri-cal method. Then the three-dimensional steady flow field within the rotor passage was simulated respectively with different axial non-uniform tip clearances. The calculation results showed that optimal axial non-uniform tip clearances could improve the compressor performance, while the efficiency and the pressure ratio of the com-pressor were increased. The flow mechanism is that the axial non-uniform tip clearance can weaken the tip leak-age vortex, blow down low-energy fluids in boundary layers and reduce both flow blockage and tip loss.

  14. Intrinsic carpal ligaments on MR and multidetector CT arthrography: comparison of axial and axial oblique planes

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Ryan K.L.; Griffith, James F.; Ng, Alex W.H.; Law, Eric K.C. [The Chinese University of Hong Kong, Department of Imaging and Interventional Radiology, Prince Of Wales Hospital, Hong Kong (China); Tse, W.L.; Wong, Clara W.Y.; Ho, P.C. [The Chinese University of Hong Kong, Department of Orthopedics and Traumatology, Prince Of Wales Hospital, Hong Kong (China)

    2017-03-15

    To compare axial and oblique axial planes on MR arthrography (MRA) and multidetector CT arthrography (CTA) to evaluate dorsal and volar parts of scapholunate (SLIL) and lunotriquetral interosseous (LTIL) ligaments. Nine cadaveric wrists of five male subjects were studied. The visibility of dorsal and volar parts of the SLIL and LTIL was graded semi-quantitatively (good, intermediate, poor) on MRA and CTA. The presence of a ligament tear was determined on arthrosocopy and sensitivity, specificity and accuracy of tear detection were calculated. Oblique axial imaging was particularly useful for delineating dorsal and volar parts of the LTIL on MRA with overall 'good' visibility increased from 11 % to 78 %. The accuracy of MRA and CTA in revealing SLIL and LTIL tear was higher using the oblique axial plane. The overall accuracy for detecting SLIL tear on CTA improved from 94 % to 100 % and from 89 % to 94 % on MRA; the overall accuracy of detecting LTIL tear on CTA improved from 89 % to 100 % and from 72 % to 89 % on MRA Oblique axial imaging during CT and MR arthrography improves detection of tears in the dorsal and volar parts of both SLIL and LTIL. (orig.)

  15. On Maximal Injectivity

    Institute of Scientific and Technical Information of China (English)

    Ming Yi WANG; Guo ZHAO

    2005-01-01

    A right R-module E over a ring R is said to be maximally injective in case for any maximal right ideal m of R, every R-homomorphism f : m → E can be extended to an R-homomorphism f' : R → E. In this paper, we first construct an example to show that maximal injectivity is a proper generalization of injectivity. Then we prove that any right R-module over a left perfect ring R is maximally injective if and only if it is injective. We also give a partial affirmative answer to Faith's conjecture by further investigating the property of maximally injective rings. Finally, we get an approximation to Faith's conjecture, which asserts that every injective right R-module over any left perfect right self-injective ring R is the injective hull of a projective submodule.

  16. Tilted versus axially placed dental implants: a meta-analysis.

    Science.gov (United States)

    Chrcanovic, Bruno Ramos; Albrektsson, Tomas; Wennerberg, Ann

    2015-02-01

    The purpose of the present review was to test the null hypothesis of no difference in the implant failure rate, marginal bone loss, and postoperative infection for patients being rehabilitated by tilted or by axially placed dental implants, against the alternative hypothesis of a difference. An electronic search without time or language restrictions was undertaken in July 2014. Eligibility criteria included clinical human studies, either randomised or not, interventional or observational. The estimates of an intervention were expressed in risk ratio (RR) and mean difference (MD) in millimetres. The search strategy resulted in 44 publications. A total of 5029 dental implants were tilted (82 failures; 1.63%), and 5732 implants were axially placed (104 failures; 1.81%). The difference between the procedures did not significantly affect the implant failure rates (P=0.40), with a RR of 1.14 (95% CI 0.84-1.56). A statistically significant difference was found for implant failures when studies evaluating implants inserted in maxillae only were pooled (RR 1.70, 95% CI 1.05-2.74; P=0.03), the same not happening for the mandible (RR 0.77, 95% CI 0.39-1.52; P=0.45). There were no apparent significant effects of tilted dental implants on the occurrence of marginal bone loss (MD 0.03, 95% CI -0.03 to 0.08; P=0.32). Due to lack of satisfactory information, meta-analysis for the outcome 'postoperative infection' was not performed. It is suggested that the differences in angulation of dental implants might not affect the implant survival or the marginal bone loss. The reliability and validity of the data collected and the potential for biases and confounding factors are some of the shortcomings of the present study. The question whether tilted implants are more at risk for failure than axially placed implants has received increasing attention in the last years. As the philosophies of treatment alter over time, a periodic review of the different concepts is necessary to refine

  17. Co-axial multicusp source for low axial energy spread ion beam production

    CERN Document Server

    Lee, Y; Leung, K N; Vujic, J L; Williams, M D; Zahir, N

    1999-01-01

    A co-axial multicusp ion source has been designed and tested. This source uses a new magnetic filter configuration. This magnetic filter is efficient in modifying the plasma potential distribution which can reduce the axial energy spread of the extracted ion beam. Energy spreads as low as 0.6 eV have been obtained. The electron temperature in this source has also been found to be about 0.1 eV. Furthermore, the new source configuration is capable of adjusting the radial plasma potential distribution which can improve the transverse ion energy, which results in a low beam emittance. The co-axial source can be used for a number of different applications such as ion projection lithography and radioactive ion beam projects.

  18. Co-axial multicusp source for low axial energy spread ion beam production

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Y. E-mail: yylee@lbl.gov; Gough, R.A.; Leung, K.N.; Vujic, J.; Williams, M.D.; Zahir, N

    1999-09-01

    A co-axial multicusp ion source has been designed and tested. This source uses a new magnetic filter configuration. This magnetic filter is efficient in modifying the plasma potential distribution which can reduce the axial energy spread of the extracted ion beam. Energy spreads as low as 0.6 eV have been obtained. The electron temperature in this source has also been found to be about 0.1 eV. Furthermore, the new source configuration is capable of adjusting the radial plasma potential distribution which can improve the transverse ion energy, which results in a low beam emittance. The co-axial source can be used for a number of different applications such as ion projection lithography and radioactive ion beam projects.

  19. Co-axial multicusp source for low axial energy spread ion beam production

    Science.gov (United States)

    Lee, Y.; Gough, R. A.; Leung, K. N.; Vujic, J.; Williams, M. D.; Zahir, N.

    1999-09-01

    A co-axial multicusp ion source has been designed and tested. This source uses a new magnetic filter configuration. This magnetic filter is efficient in modifying the plasma potential distribution which can reduce the axial energy spread of the extracted ion beam. Energy spreads as low as 0.6 eV have been obtained. The electron temperature in this source has also been found to be about 0.1 eV. Furthermore, the new source configuration is capable of adjusting the radial plasma potential distribution which can improve the transverse ion energy, which results in a low beam emittance. The co-axial source can be used for a number of different applications such as ion projection lithography and radioactive ion beam projets.

  20. Axial flow heat exchanger devices and methods for heat transfer using axial flow devices

    Energy Technology Data Exchange (ETDEWEB)

    Koplow, Jeffrey P.

    2016-02-16

    Systems and methods described herein are directed to rotary heat exchangers configured to transfer heat to a heat transfer medium flowing in substantially axial direction within the heat exchangers. Exemplary heat exchangers include a heat conducting structure which is configured to be in thermal contact with a thermal load or a thermal sink, and a heat transfer structure rotatably coupled to the heat conducting structure to form a gap region between the heat conducting structure and the heat transfer structure, the heat transfer structure being configured to rotate during operation of the device. In example devices heat may be transferred across the gap region from a heated axial flow of the heat transfer medium to a cool stationary heat conducting structure, or from a heated stationary conducting structure to a cool axial flow of the heat transfer medium.

  1. Lighten Up: Specific Postural Instructions Affect Axial Rigidity and Step Initiation in Patients With Parkinson's Disease.

    Science.gov (United States)

    Cohen, Rajal G; Gurfinkel, Victor S; Kwak, Elizabeth; Warden, Amelia C; Horak, Fay B

    2015-10-01

    Parkinson's disease (PD) is associated with stooped postural alignment, increased postural sway, and reduced mobility. The Alexander Technique (AT) is a mindfulness-based approach to improving posture and mobility by reducing muscular interference while maintaining upward intentions. Evidence suggests that AT can reduce disability associated with PD, but a mechanism for this effect has not yet been established. We investigated whether AT-based instructions reduce axial rigidity and increase upright postural alignment, and whether these instructions have different effects on postural alignment, axial rigidity, postural sway, and mobility than effort-based instructions regarding posture. Twenty subjects with PD practiced 2 sets of instructions and then attempted to implement both approaches (as well as a relaxed control condition) during quiet standing and step initiation. The "Lighten Up" instructions relied on AT principles of reducing excess tension while encouraging length. The "Pull Up" instructions relied on popular concepts of effortful posture correction. We measured kinematics, resistance to axial rotation, and ground reaction forces. Both sets of experimental instructions led to increases in upright postural alignment relative to the control condition. Only the Lighten Up instructions led to reduced postural sway, reduced axial postural tone, greater modifiability of tone, and a smoother center of pressure trajectory during step initiation, possibly indicating greater movement efficiency. Mindful movement approaches such as AT may benefit balance and mobility in subjects with PD by acutely facilitating increased upright postural alignment while decreasing rigidity. © The Author(s) 2015.

  2. Axial level-dependent molecular and cellular mechanisms underlying the genesis of the embryonic neural plate.

    Science.gov (United States)

    Kondoh, Hisato; Takada, Shinji; Takemoto, Tatsuya

    2016-06-01

    The transcription factor gene Sox2, centrally involved in neural primordial regulation, is activated by many enhancers. During the early stages of embryonic development, Sox2 is regulated by the enhancers N2 and N1 in the anterior neural plate (ANP) and posterior neural plate (PNP), respectively. This differential use of the enhancers reflects distinct regulatory mechanisms underlying the genesis of ANP and PNP. The ANP develops directly from the epiblast, triggered by nodal signal inhibition, and via the combined action of TFs SOX2, OTX2, POU3F1, and ZIC2, which promotes the the ANP development and inhibits other cell lineages. In contrast, the PNP is derived from neuromesodermal bipotential axial stem cells that develop into the neural plate when Sox2 is activated by the N1 enhancer, whereas they develop into the paraxial mesoderm when the N1 enhancer is repressed by the action of TBX6. The axial stem cells are maintained by the activity of WNT3a and T (Brachyury). However, at axial levels more anterior to the 8th somites (cervical levels), the development of both the neural plate and somite proceeds in the absence of WNT3a, T, or TBX6. These observations indicate that distinct molecular and cellular mechanisms determine neural plate genesis based on the axial level, and contradict the classical concept of the term "neural induction," which assumes a pan-neural plate mechanism.

  3. The ASAS Criteria for Axial Spondyloarthritis: Strengths, Weaknesses, and Proposals for a Way Forward.

    Science.gov (United States)

    van der Linden, Sjef; Akkoc, Nurullah; Brown, Matthew A; Robinson, Philip C; Khan, Muhammad A

    2015-09-01

    Classification criteria should facilitate selection of similar patients for clinical and epidemiologic studies, therapeutic trials, and research on etiopathogenesis to enable comparison of results across studies from different centers. We critically appraise the validity and performance of the Assessment of SpondyloArthritis international Society (ASAS) classification criteria for axial spondyloarthritis (axSpA). It is still debatable whether all patients fulfilling these criteria should be considered as having true axSpA. Patients with radiographically evident disease by the ASAS criteria are not necessarily identical with ankylosing spondylitis (AS) as classified by the modified New York criteria. The complex multi-arm selection design of the ASAS criteria induces considerable heterogeneity among patients so classified, and applying them in settings with a low prevalence of axial spondyloarthritis (SpA) greatly increases the proportion of subjects falsely classified as suffering from axial SpA. One of the unmet needs in non-radiographic form of axial SpA is to have reliable markers that can identify individuals at risk for progression to AS and thereby facilitate early intervention trials designed to prevent such progression. We suggest needed improvements of the ASAS criteria for axSpA, as all criteria sets should be regarded as dynamic concepts open to modifications or updates as our knowledge advances.

  4. Epoetin Alfa Injection

    Science.gov (United States)

    ... Combivir), a medication used to treat human immunodeficiency virus (HIV). Epoetin alfa injection is also used before ... inject epoetin alfa, as directed by your doctor. Write down the date, time, dose of epoetin alfa ...

  5. Collagenase Clostridium Histolyticum Injection

    Science.gov (United States)

    Collagenase Clostridium histolyticum injection is used to treat Dupuytren's contracture (a painless thickening and tightening of tissue [cord] beneath ... of tissue can be felt upon examination. Collagenase Clostridium histolyticum injection is also used to treat Peyronie's ...

  6. Iron Sucrose Injection

    Science.gov (United States)

    Iron sucrose injection is used treat iron-deficiency anemia (a lower than normal number of red blood cells due ... and may cause the kidneys to stop working). Iron sucrose injection is in a class of medications called iron ...

  7. Intracytoplasmic sperm injection

    Science.gov (United States)

    Intracytoplasmic sperm injection, or ICSI, is a form of in vitro fertilization in which fertilization occurs outside of the ... laboratory dish. Within a few hours, a single sperm is injected through a fine needle into the ...

  8. Sodium Ferric Gluconate Injection

    Science.gov (United States)

    Sodium ferric gluconate injection is used to treat iron-deficiency anemia (a lower than normal number of ... are also receiving the medication epoetin (Epogen, Procrit). Sodium ferric gluconate injection is in a class of ...

  9. Calcitonin Salmon Injection

    Science.gov (United States)

    Calcitonin salmon injection is used to treat osteoporosis in postmenopausal women. Osteoporosis is a disease that causes bones to weaken and break more easily. Calcitonin salmon injection is also used to treat Paget's disease ...

  10. Other Injectable Medications

    Science.gov (United States)

    ... July 17, 2013 Last Edited: February 22, 2017 Articles from Diabetes Forecast® magazine: cg-infusion-sets,meds-bg-injectables,cg-injection-aids, In this section Treatment and Care Medication Insulin & ...

  11. Injection losses and protection

    CERN Document Server

    Bartmann, W; Baudrenghien, P; Bracco, C; Dehning, B; Di Mauro, A; Drosdal, L; Emery, J; Goddard, B; Holzer, E B; Höfle, W; Kain, V; Meddahi, M; Radaelli, S; Shaposhnilova, E; Uythoven, J; Valuch, D; Wenninger, J; Zamantzas, C; Gianfelice-Wendt, E

    2012-01-01

    Injection losses are compared for 2010 and 2011 operation. Mitigation techniques which were put in place in 2010 to reduce losses at injection are described. Issues in 2011 operation, their potential improvements and the performance reach for 2012 are shown.

  12. Axial Tomography from Digitized Real Time Radiography

    Science.gov (United States)

    Zolnay, A. S.; McDonald, W. M.; Doupont, P. A.; McKinney, R. L.; Lee, M. M.

    1985-01-18

    Axial tomography from digitized real time radiographs provides a useful tool for industrial radiography and tomography. The components of this system are: x-ray source, image intensifier, video camera, video line extractor and digitizer, data storage and reconstruction computers. With this system it is possible to view a two dimensional x-ray image in real time at each angle of rotation and select the tomography plane of interest by choosing which video line to digitize. The digitization of a video line requires less than a second making data acquisition relatively short. Further improvements on this system are planned and initial results are reported.

  13. Ankylosing Spondylitis versus Nonradiographic Axial Spondyloarthritis

    DEFF Research Database (Denmark)

    Glintborg, Bente; Sørensen, Inge J; Østergaard, Mikkel

    2017-01-01

    OBJECTIVE: To compare baseline disease activity and treatment effectiveness in biologic-naive patients with nonradiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) who initiate tumor necrosis factor inhibitor (TNFi) treatment and to study the role of potential confounders....../disease duration/TNFi-type/smoking/baseline disease activity) on TNFi adherence and response [e.g., Bath Ankylosing Spondylitis Activity Index (BASDAI) 50%/20 mm]. RESULTS: The study included 1250 TNFi-naive patients with axSpA (29% nr-axSpA, 50% AS, 21% lacked radiographs of sacroiliac joints). Patients...

  14. Tunable axial potentials for atom chip waveguides

    CERN Document Server

    Stickney, James A; Imhof, Eric; Kroese, Bethany R; Crow, Jonathon A R; Olson, Spencer E; Squires, Matthew B

    2014-01-01

    We present a method for generating algebraically precise magnetic potentials along the axis of a cold atom waveguide near the surface of an atom chip. With a single chip design consisting of several wire pairs, various axial potentials can be created, including double wells, triple wells, and pure harmonic traps with suppression of higher order terms. We characterize the error along a harmonic trap between the expected algebraic form and magnetic field simulations and find excel- lent agreement, particularly at small displacements from the trap center. Finally, we demonstrate experimental control over the bottom fields of an asymmetric double well potential.

  15. Composite Axial Flow Propulsor for Small Aircraft

    OpenAIRE

    2005-01-01

    This work focuses on the design of an axial flow ducted fan driven by a reciprocating engine. The solution minimizes the turbulization of the flow around the aircraft. The fan has a rotor - stator configuration. Due to the need for low weight of the fan, a carbon/epoxy composite material was chosen for the blades and the driving shaft.The fan is designed for optimal isentropic efficiency and free vortex flow. A stress analysis of the rotor blade was performed using the Finite Element  Method....

  16. Cervical Spine Axial Rotation Goniometer Design

    Directory of Open Access Journals (Sweden)

    Emin Ulaş Erdem

    2012-06-01

    Full Text Available To evaluate the cervical spine rotation movement is quiet harder than other joints. Configuration and arrangement of current goniometers and devices is not always practic in clinics and some methods are quiet expensive. The cervical axial rotation goniometer designed by the authors is consists of five pieces (head apparatus, chair, goniometric platform, eye pads and camera. With this goniometer design a detailed evaluation of cervical spine range of motion can be obtained. Besides, measurement of "joint position sense" which is recently has rising interest in researches can be made practically with this goniometer.

  17. Through-Flow Calculations in Axial Turbomachinery

    Science.gov (United States)

    1976-10-01

    downstzega of the effective throat which is displaced upstream away from its kominal plano flow •_stion. Test data .-n nigh deflection blading tested in...AXIAL PIE ANGs-L;- VrELOC.I- T/Y SI~NG,’ c (,o nd) 2 .959 00 SO~ IS~N1RO iCoWLE tNJ\\\\ NJ\\v ON45l~5INi +U~SWC E.AAINZN5W~N3~6 8Lk5~ P-tO RM~ C -5A

  18. Single Band Helical Antenna in Axial Mode

    Directory of Open Access Journals (Sweden)

    Parminder Singh

    2012-11-01

    Full Text Available Helical antennas have been widely used in a various useful applications, due to their low weight and low profile conformability, easy and cheap realization.Radiation properties of this antenna are examined both theoretically and experimentally. In this paper, an attempt has been made to investigate new helical antenna structure for Applications. CST MWS Software is used for the simulation and design calculations of the helical antennas. The axial ratio, return loss, VSWR, Directivity, gain, radiation pattern is evaluated. Using CST MWS simulation software proposed antenna is designed/simulated and optimized. The antenna exhibits a single band from 0 GHz to 3 GHz for GPS and several satellite applications

  19. Compact toroid injection into C-2U

    Science.gov (United States)

    Roche, Thomas; Gota, H.; Garate, E.; Asai, T.; Matsumoto, T.; Sekiguchi, J.; Putvinski, S.; Allfrey, I.; Beall, M.; Cordero, M.; Granstedt, E.; Kinley, J.; Morehouse, M.; Sheftman, D.; Valentine, T.; Waggoner, W.; the TAE Team

    2015-11-01

    Sustainment of an advanced neutral beam-driven FRC for a period in excess of 5 ms is the primary goal of the C-2U machine at Tri Alpha Energy. In addition, a criteria for long-term global sustainment of any magnetically confined fusion reactor is particle refueling. To this end, a magnetized coaxial plasma-gun has been developed. Compact toroids (CT) are to be injected perpendicular to the axial magnetic field of C-2U. To simulate this environment, an experimental test-stand has been constructed. A transverse magnetic field of B ~ 1 kG is established (comparable to the C-2U axial field) and CTs are fired across it. As a minimal requirement, the CT must have energy density greater than that of the magnetic field it is to penetrate, i.e., 1/2 ρv2 >=B2 / 2μ0 . This criteria is easily met and indeed the CTs traverse the test-stand field. A preliminary experiment on C-2U shows the CT also capable of penetrating into FRC plasmas and refueling is observed resulting in a 20 - 30% increase in total particle number per single-pulsed CT injection. Results from test-stand and C-2U experiments will be presented.

  20. Beam injection into RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, W.; Hahn, H.; MacKay, W.W.; Satogata, T.; Tsoupas, N.; Zhang, W.

    1997-07-01

    During the RHIC sextant test in January 1997 beam was injected into a sixth of one of the rings for the first time. The authors describe the injection zone and its bottlenecks. They report on the commissioning of the injection system, on beam based measurements of the kickers and the application program to steer the beam.

  1. Injection moulding antireflective nanostructures

    DEFF Research Database (Denmark)

    Christiansen, Alexander Bruun; Clausen, Jeppe Sandvik; Mortensen, N. Asger

    2014-01-01

    in an injection moulding process, to fabricate the antireflective surfaces. The cycle-time was 35 s. The injection moulded structures had a height of 125 nm, and the visible spectrum reflectance of injection moulded black polypropylene surfaces was reduced from 4.5±0.5% to 2.5±0.5%. The gradient of the refractive...

  2. Injection moulding antireflective nanostructures

    DEFF Research Database (Denmark)

    Christiansen, Alexander Bruun; Clausen, Jeppe Sandvik; Mortensen, N. Asger

    in an injection moulding process, to fabricate the antireflective surfaces. The cycle-time was 35 s. The injection moulded structures had a height of 125 nm, and the visible spectrum reflectance of injection moulded black polypropylene surfaces was reduced from 4.5±0.5% to 2.5±0.5%. The gradient of the refractive...

  3. On Modules Whose Singular Subgenerated Modules Are Weakly Injective

    Institute of Scientific and Technical Information of China (English)

    S. Dhompongsa; J. Sanwong; S.Plubtieng; H.Tansee

    2001-01-01

    Rings over which every singular right module is injective (briefly,right SI-rings) were introduced and investigated by Goodearl. Weakly injective modules, as a generalization of injective modules, were introduced by Jain and modules are weakly injective, which we call SwI-rings. This concept is extended to SwI-modules, i.e., modules whose singular subgenerated modules are weakly injective. Several characterizations and properties of SwI-rings and SwI-modules are obtained which generalize some earlier known results on SI-rings and weakly semisimple rings.

  4. Axial residual stresses in boron fibers

    Science.gov (United States)

    Behrendt, D. R.

    1978-01-01

    A method of measuring axial residual stresses in boron fibers is presented. With this method, the axial residual stress distribution as a function of radius is determined from the fiber surface to the core including the average residual stress in the core. Such measurements on boron on tungsten (B/W) fibers show that the residual stresses for 102, 142, 203, and 366 micron diam fibers are similar, being compressive at the surface and changing monotonically to a region of tensile stress within the boron. At approximately 25% of the original radius, the stress reaches a maximum tensile stress of about 860 MN sq m and then decreases to a compressive stress near the tungsten boride core. Data are presented for 203-micron diam B/W fibers that show annealing above 900 C reduces the residual stresses. A comparison between 102-micron diam B/W and boron on carbon (B/C) show that the residual stresses are similar in the outer regions of the fibers, but that large differences near and in the core are observed. Fracture of boron fibers is discussed.

  5. Single Rod Vibration in Axial Flow

    Science.gov (United States)

    Weichselbaum, Noah; Wang, Shengfu; Bardet, Philippe

    2013-11-01

    Fluid structure interaction of a single rod in axial flow is a coupled dynamical system present in many application including nuclear reactors, steam generators, and towed antenna arrays. Fluid-structure response can be quantified thanks to detailed experimental data where both structure and fluid responses are recorded. Such datum deepen understanding of the physics inherent to the system and provide high-dimensionality quantitative measurements to validate coupled structural and CFD codes with various level of complexity. In this work, single rods fixed on both ends in a concentric pipe, are subjected to an axial flow with Reynolds number based on hydraulic diameter of Re =4000. Rods of varying material stiffness and diameter are utilized in the experiment resulting in a range of dimensionless U between 0.5 and 1, where U = (ρA/EI)1/2uL. Experimental measurements of the velocity field around the rod are taken with PIV from time-resolved Nd:YLF laser and a high speed CMOS camera. Three-dimensional and temporal vibration and deflection of the rod is recorded with shadowgraphy utilizing two sets of pulsed high power LED and dedicated CMOS camera. Through integration of these two diagnostics, it is possible to reconstruct the full FSI domain providing unique validation data.

  6. Multi-frequency axial transmission bone ultrasonometer.

    Science.gov (United States)

    Tatarinov, Alexey; Egorov, Vladimir; Sarvazyan, Noune; Sarvazyan, Armen

    2014-07-01

    The last decade has seen a surge in the development of axial transmission QUS (Quantitative UltraSound) technologies for the assessment of long bones using various modes of acoustic waves. The condition of cortical bones and the development of osteoporosis are determined by numerous mechanical, micro-structural, and geometrical or macro-structural bone properties like hardness, porosity and cortical thickness. Such complex manifestations of osteoporosis require the evaluation of multiple parameters with different sensitivities to the various properties of bone that are affected by the disease. This objective may be achieved by using a multi-frequency ultrasonic examination The ratio of the acoustic wavelength to the cortical thickness can be changed by varying the frequency of the ultrasonic pulse propagating through the long bone that results in the change in composition of the induced wave comprised of a set of numerous modes of guided, longitudinal, and surface acoustic waves. The multi-frequency axial transmission QUS method developed at Artann Laboratories (Trenton, NJ) is implemented in the Bone Ultrasonic Scanner (BUSS). In the current version of the BUSS, a train of ultrasonic pulses with 60, 100, 400, 800, and 1200 kHz frequencies is used. The developed technology was tested on a variety of bone phantoms simulating normal, osteopenic, and osteoporotic bones. The results of this study confirm the feasibility of the multi-frequency approach for the assessment of the processes leading to osteoporosis.

  7. Concept theory

    DEFF Research Database (Denmark)

    Hjørland, Birger

    2009-01-01

      Concept theory is an extremely broad, interdisciplinary and complex field of research related to many deep fields with very long historical traditions without much consensus. However, information science and knowledge organization cannot avoid relating to theories of concepts. Knowledge...... organizing systems (e.g. classification systems, thesauri and ontologies) should be understood as systems basically organizing concepts and their semantic relations. The same is the case with information retrieval systems. Different theories of concepts have different implications for how to construe......, evaluate and use such systems. Based on "a post-Kuhnian view" of paradigms this paper put forward arguments that the best understanding and classification of theories of concepts is to view and classify them in accordance with epistemological theories (empiricism, rationalism, historicism and pragmatism...

  8. The development of an air injection system for the forced response testing of axial compressors

    CSIR Research Space (South Africa)

    Wegman, Erik J

    2013-06-01

    Full Text Available to generate a blade response of different nodal diameters using the exciters. The blade response was also found to vary depending on the number of rotor holes, air supply pressure and sweep rate used for the exciters. Following completion of the sub...

  9. Axially symmetric static sources: A general framework and some analytical solutions

    CERN Document Server

    Herrera, L; Ibañez, J; Ospino, J

    2013-01-01

    We provide all basic equations and concepts required to carry out a general study on axially symmetric static sources. The Einstein equations and the conservation equations are written down for a general anisotropic static fluid endowed with axial symmetry. The structure scalars are calculated and the inhomogeneity factors are identified. Finally some exact analytical solutions were found. One of these solutions describes an incompressible spheroid with isotropic pressure and becomes the well known interior Schwarzschild solution in the spherically symmetric limit, however it cannot be matched smoothly to any Weyl exterior metric. Another family of solutions was found that corresponds to an anisotropic fluid distribution and can in principle be matched to a Weyl exterior.

  10. Novel approach for determining the optimal axial preload of a simulating rotary table spindle system

    Institute of Scientific and Technical Information of China (English)

    SHAN Xiao-biao; XIE Tao; CHEN Wei-shan

    2007-01-01

    This paper presents a new theoretical model to determine the optimal axial preload ora spindle system, for challenging the traditional method which relies heavily on experience of engineers. The axial preloading stiffness was treated as the sum of the spindle modal stiffness and the framework elastic stiffness, based on a novel concept that magnitude of preloads can be controlled by measuring the resonant frequency of a spindle system. By employing an example of a certain type of aircraft simulating rotary table, the modal stiffness was measured on the Agilent 35670A Dynamic Signal Analyzer by experimental modal analysis. The equivalent elastic stiffness was simulated by both finite element analysis in ANSYS(R) and a curve fitting in MATLAB(R). Results showed that the static preloading stiffness of the spindle was 7.2125×107 N/m, and that the optimal preloading force was 120.0848 N. Practical application proved the feasibility of our method.

  11. Multi-Element Lean Direct Injection Combustor Module Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to develop a Multi-Element Lean Direct Injection, ME-LDI, Combustion concept with the following innovative features: 1. Independent, mini burning zones...

  12. Study on the Axial Dispersion of Liquid in Column Flotation

    Institute of Scientific and Technical Information of China (English)

    周鵾; 曾爱武; 高长宝; 余国琮

    2003-01-01

    An experimental study on the axial dispersion of liquid was carried out in a 0.382-m-ID flotation column packed with different structured packings or free of packings. The correlations of axial Peclet numbers with the liquid and gas superficial Reynolds numbers were developed for various packings. Among the packings tested, it is found that in the column packed with 250Y or 350Y packings the axial dispersion is the lowest. The addition of frother can decrease the axial dispersion. By the simulation analysis of the one-dimension dispersion model of packed flotation column, it is found that small axial dispersion, high collection rate constant and low axial liquid velocity can increase the collection zone recovery.

  13. Intra-arterial injection of Tc-99m MDP

    Directory of Open Access Journals (Sweden)

    Ebru Salmanoglu

    2016-03-01

    Full Text Available Bone scintigraphy is applied to evaluate abnormalities of axial skeleton and appendicular skeleton including osteomyelitis, prosthesis infection, prosthesis loosening, avascular necrosis, stress fracture, bone metastasis. Technetium-99m methylene diphosphonate (Tc-99m MDP is most common used radiopharmaceutical. Injection of Tc-99m MDP should be done intravenous but it can be done intra-arterial, accidentally. After intra-arterial injection of Tc-99m MDP, it cause prominent soft tissue uptake distal to the injection site. This situation can create confusion in the scintigraphic images. Usually, it imitate reflex sympathetic dystrophy, so differential diagnosis is important. The aim of this report is to present the appearance of inadvertent intra-arterial injection of Tc-99m MDP. [Cukurova Med J 2016; 41(0.100: 79-82

  14. High-Frequency Axial Fatigue Test Procedures for Spectrum Loading

    Science.gov (United States)

    2016-07-20

    REPORT NO: NAWCADPAX/TIM-2016/49 HIGH - FREQUENCY AXIAL FATIGUE TEST PROCEEDURES FOR SPECTRUM LOADING by David T. Rusk, AIR...OF THE NAVY NAVAL AIR WARFARE CENTER AIRCRAFT DIVISION PATUXENT RIVER, MARYLAND NAWCADPAX/TIM-2016/49 20 July 2016 HIGH - FREQUENCY AXIAL...Technical Information Memorandum 3. DATES COVERED 4. TITLE AND SUBTITLE High - Frequency Axial Fatigue Test Procedures for Spectrum Loading

  15. A technique to determine a desired preparation axial inclination.

    Science.gov (United States)

    Parker, M Harry; Ivanhoe, John R; Blalock, John S; Frazier, Kevin B; Plummer, Kevin D

    2003-10-01

    The guidelines recommended in the literature for the convergence angle of a crown preparation vary from 3 to 24 degrees. There is a lack of guidelines on techniques to achieve a specific axial inclination. The purpose of this article was to present a practical technique, with a diamond rotary cutting instrument of known axial inclination, to determine the diamond rotary cutting instrument angulations required to achieve the desired axial inclination of a preparation.

  16. Design and Test of a Transonic Axial Splittered Rotor

    Science.gov (United States)

    2015-06-15

    AXIAL SPLITTERED ROTOR A new design procedure was developed that uses commercial-off-the-shelf software (MATLAB, SolidWorks , and ANSYS-CFX) for the...TRANSONIC AXIAL SPLITTERED ROTOR Report Title A new design procedure was developed that uses commercial-off-the-shelf software (MATLAB, SolidWorks , and...that uses commercial-off-the-shelf software (MATLAB, SolidWorks , and ANSYS-CFX) for the geometric rendering and analysis of a transonic axial

  17. Rotordynamics of Turbine Labyrinth Seals with Rotor Axial Shifting

    OpenAIRE

    Jinxiang Xi; Rhode, David L.

    2006-01-01

    Rotors in high-performance steam turbines experience a significant axial shifting during starting and stopping processes due to thermal expansion, for example. This axial shifting could significantly alter the flow pattern and the flow-induced rotordynamic forces in labyrinth seals, which in turn, can considerably affect the rotor-seal system performance. This paper investigates the influence of the rotor axial shifting on leakage rate as well as rotordynamic forces in hi...

  18. Modular functional organisation of the axial locomotor system in salamanders.

    Science.gov (United States)

    Cabelguen, Jean-Marie; Charrier, Vanessa; Mathou, Alexia

    2014-02-01

    Most investigations on tetrapod locomotion have been concerned with limb movements. However, there is compelling evidence that the axial musculoskeletal system contributes to important functions during locomotion. Adult salamanders offer a remarkable opportunity to examine these functions because these amphibians use axial undulations to propel themselves in both aquatic and terrestrial environments. In this article, we review the currently available biological data on axial functions during various locomotor modes in salamanders. We also present data showing the modular organisation of the neural networks that generate axial synergies during locomotion. The functional implication of this modular organisation is discussed.

  19. Energy Dissipation in Sandwich Structures During Axial Compression

    DEFF Research Database (Denmark)

    Urban, Jesper

    2002-01-01

    The purpose of this paper is to investigate the energy dissipation in sandwich structures during axial crushing. Axial crushing tests on six sandwich elements are described. The sandwich elements consist of a polyurethane core and E-glass/Polyester skin. The elements compare to full-scale structu......The purpose of this paper is to investigate the energy dissipation in sandwich structures during axial crushing. Axial crushing tests on six sandwich elements are described. The sandwich elements consist of a polyurethane core and E-glass/Polyester skin. The elements compare to full...

  20. Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients' own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept.

    Science.gov (United States)

    Choukroun, J; Ghanaati, S

    2017-03-10

    The aim of this study was to analyze systematically the influence of the relative centrifugation force (RCF) on leukocytes, platelets and growth factor release within fluid platelet-rich fibrin matrices (PRF). Systematically using peripheral blood from six healthy volunteers, the RCF was reduced four times for each of the three experimental protocols (I-III) within the spectrum (710-44 g), while maintaining a constant centrifugation time. Flow cytometry was applied to determine the platelets and leukocyte number. The growth factor concentration was quantified 1 and 24 h after clotting using ELISA. Reducing RCF in accordance with protocol-II (177 g) led to a significantly higher platelets and leukocytes numbers compared to protocol-I (710 g). Protocol-III (44 g) showed a highly significant increase of leukocytes and platelets number in comparison to -I and -II. The growth factors' concentration of VEGF and TGF-β1 was significantly higher in protocol-II compared to -I, whereas protocol-III exhibited significantly higher growth factor concentration compared to protocols-I and -II. These findings were observed among 1 and 24 h after clotting, as well as the accumulated growth factor concentration over 24 h. Based on the results, it has been demonstrated that it is possible to enrich PRF-based fluid matrices with leukocytes, platelets and growth factors by means of a single alteration of the centrifugation settings within the clinical routine. We postulate that the so-called low speed centrifugation concept (LSCC) selectively enriches leukocytes, platelets and growth factors within fluid PRF-based matrices. Further studies are needed to evaluate the effect of cell and growth factor enrichment on wound healing and tissue regeneration while comparing blood concentrates gained by high and low RCF.

  1. Aerodynamic Modelling and Optimization of Axial Fans

    DEFF Research Database (Denmark)

    Sørensen, Dan Nørtoft

    A numerically efficient mathematical model for the aerodynamics oflow speed axial fans of the arbitrary vortex flow type has been developed.The model is based on a blade-element principle, whereby therotor is divided into a number of annular streamtubes.For each of these streamtubes relations...... for velocity, pressure andradial position are derived from the conservationlaws for mass, tangential momentum and energy.The resulting system of equations is non-linear and, dueto mass conservation and pressure equilibrium far downstream of the rotor,strongly coupled.The equations are solved using the Newton...... distributionsof pitch angle and chord length have been chosen as independent variablesin the optimizations.Besides restricting the geometry of the rotor,constraints have been added to ensure a required pressure rise as well asnon-stalled flow conditions.Optimizations have been performed tomaximize the mean value...

  2. The Axial Part Phrase in Japanese

    Directory of Open Access Journals (Sweden)

    Kaori Takamine

    2007-01-01

    Full Text Available In this paper, I investigate the categorial status of spatial terms in locative/directional expressions in Japanese. I will show that a certain class of spatial terms have a distinct categorial status from both regular postpositions and nouns. On one hand, syntactic diagnostics such as doubling, coordination by to, and co-occurrence with demonstratives indicate that these spatial terms belong to a nominal category rather than to a postpositional category. On the other hand, the fact that these spatial terms are modified by range modifiers indicates that they are more similar to regular postpositions than to nouns. On the basis of these diagnostics, I will argue that spatial terms in Japanese need to be assigned a new category Axial Part Phrase which is proposed by Svenonius 2006.

  3. Composite Axial Flow Propulsor for Small Aircraft

    Directory of Open Access Journals (Sweden)

    R. Poul

    2005-01-01

    Full Text Available This work focuses on the design of an axial flow ducted fan driven by a reciprocating engine. The solution minimizes the turbulization of the flow around the aircraft. The fan has a rotor - stator configuration. Due to the need for low weight of the fan, a carbon/epoxy composite material was chosen for the blades and the driving shaft.The fan is designed for optimal isentropic efficiency and free vortex flow. A stress analysis of the rotor blade was performed using the Finite Element  Method. The skin of the blade is calculated as a laminate and the foam core as a solid. A static and dynamic analysis were made. The RTM technology is compared with other technologies and is described in detail. 

  4. Aerodynamics of advanced axial-flow turbomachinery

    Science.gov (United States)

    Serovy, G. K.; Kavanagh, P.; Kiishi, T. H.

    1980-01-01

    A multi-task research program on aerodynamic problems in advanced axial-flow turbomachine configurations was carried out at Iowa State University. The elements of this program were intended to contribute directly to the improvement of compressor, fan, and turbine design methods. Experimental efforts in intra-passage flow pattern measurements, unsteady blade row interaction, and control of secondary flow are included, along with computational work on inviscid-viscous interaction blade passage flow techniques. This final report summarizes the results of this program and indicates directions which might be taken in following up these results in future work. In a separate task a study was made of existing turbomachinery research programs and facilities in universities located in the United States. Some potentially significant research topics are discussed which might be successfully attacked in the university atmosphere.

  5. Casimir Energy in the Axial Gauge

    CERN Document Server

    Esposito, G; Kirsten, K; Esposito, Giampiero; Kamenshchik, Alexander Yu.; Kirsten, Klaus

    2000-01-01

    The zero-point energy of a conducting spherical shell is studied by imposing the axial gauge via path-integral methods, with boundary conditions on the electromagnetic potential and ghost fields. The coupled modes are then found to be the temporal and longitudinal modes for the Maxwell field. The resulting system can be decoupled by studying a fourth-order differential equation with boundary conditions on longitudinal modes and their second derivatives. The exact solution of such equation is found by using a Green-function method, and is obtained from Bessel functions and definite integrals involving Bessel functions. Complete agreement with a previous path-integral analysis in the Lorenz gauge, and with Boyer's value, is proved in detail.

  6. Epidural injections for back pain

    Science.gov (United States)

    ESI; Spinal injection for back pain; Back pain injection; Steroid injection - epidural; Steroid injection - back ... be pregnant What medicines you are taking, including herbs, supplements, and other drugs you bought without a ...

  7. Travelling Concepts

    DEFF Research Database (Denmark)

    Simonsen, Karen-Margrethe

    2013-01-01

    Review of "Travelling Concepts, Metaphors, and Narratives: Literary and Cultural Studies in an Age of Interdisciplinary Research" ed. by Sibylle Baumgarten, Beatrice Michaelis and Ansagar Nünning, Trier; Wissenschaftlicher Verlag Trier, 2012......Review of "Travelling Concepts, Metaphors, and Narratives: Literary and Cultural Studies in an Age of Interdisciplinary Research" ed. by Sibylle Baumgarten, Beatrice Michaelis and Ansagar Nünning, Trier; Wissenschaftlicher Verlag Trier, 2012...

  8. Multi-Element Lean Direct Injection Combustor Single Element Demonstration Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to demonstrate the feasibility in a single element of a Multi-Element Lean Direct Injection, ME-LDI, Combustion concept. The concept will have the...

  9. Underground Injection Control (UIC)

    Science.gov (United States)

    Provide information on: individual injection well classes; regulations specific to each well class; technical guidance; compliance assistance; federal, state, and tribal/territory roles and responsibilities.

  10. Ferric Carboxymaltose Injection

    Science.gov (United States)

    ... pharmacist if you are allergic to ferric carboxymaltose injection, ferumoxytol (Feraheme), iron dextran (Dexferrum, Infed), iron sucrose (Venofer), or sodium ferric gluconate (Ferrlecit); any other ...

  11. Piezoelectric Injection Systems

    Science.gov (United States)

    Mock, R.; Lubitz, K.

    The origin of direct injection can be doubtlessly attributed to Rudolf Diesel who used air assisted injection for fuel atomisation in his first self-ignition engine. Although it became apparent already at that time that direct injection leads to reduced specific fuel consumption compared to other methods of fuel injection, it was not used in passenger cars for the moment because of its disadvantageous noise generation as the requirements with regard to comfort were seen as more important than a reduced specific consumption.

  12. Parameter estimation and actuator characteristics of hybrid magnetic bearings for axial flow blood pump applications.

    Science.gov (United States)

    Lim, Tau Meng; Cheng, Shanbao; Chua, Leok Poh

    2009-07-01

    Axial flow blood pumps are generally smaller as compared to centrifugal pumps. This is very beneficial because they can provide better anatomical fit in the chest cavity, as well as lower the risk of infection. This article discusses the design, levitated responses, and parameter estimation of the dynamic characteristics of a compact hybrid magnetic bearing (HMB) system for axial flow blood pump applications. The rotor/impeller of the pump is driven by a three-phase permanent magnet brushless and sensorless motor. It is levitated by two HMBs at both ends in five degree of freedom with proportional-integral-derivative controllers, among which four radial directions are actively controlled and one axial direction is passively controlled. The frequency domain parameter estimation technique with statistical analysis is adopted to validate the stiffness and damping coefficients of the HMB system. A specially designed test rig facilitated the estimation of the bearing's coefficients in air-in both the radial and axial directions. Experimental estimation showed that the dynamic characteristics of the HMB system are dominated by the frequency-dependent stiffness coefficients. By injecting a multifrequency excitation force signal onto the rotor through the HMBs, it is noticed in the experimental results the maximum displacement linear operating range is 20% of the static eccentricity with respect to the rotor and stator gap clearance. The actuator gain was also successfully calibrated and may potentially extend the parameter estimation technique developed in the study of identification and monitoring of the pump's dynamic properties under normal operating conditions with fluid.

  13. Through flow analysis within axial flow turbomachinery blade rows

    Science.gov (United States)

    Girigoswami, H.

    1986-09-01

    Using Katsanis' Through Flow Code, inviscid flow through an axial flow compressor rotor blade as well as flow through inlet guide vanes are analyzed and the computed parameters such as meridional velocity distribution, axial velocity distribution along radial lines, and velocity distribution over blade surfaces are presented.

  14. Improved axial position detection in optical tweezers measurements

    DEFF Research Database (Denmark)

    Dreyer, Jakob Kisbye; Berg-Sørensen, Kirstine; Oddershede, Lene

    2004-01-01

    We investigate the axial position detection of a trapped microsphere in an optical trap by using a quadrant photodiode. By replacing the photodiode with a CCD camera, we obtain detailed information on the light scattered by the microsphere. The correlation of the interference pattern with the axial...

  15. Testing of Axially Loaded Bucket Foundation with Applied Overburden Pressure

    DEFF Research Database (Denmark)

    Vaitkunaite, Evelina; Ibsen, Lars Bo; Nielsen, Benjaminn Nordahl

    This report analyses laboratory testing data performed with a bucket foundation model subjected to axial loading. The examinations were conducted at the Geotechnical laboratory of Aalborg University. The report aims at showing and discussing the results of the static and cyclic axial loading tests...

  16. Test Setup for Axially Loaded Piles in Sand

    DEFF Research Database (Denmark)

    Thomassen, Kristina

    The test setup for testing axially static and cyclic loaded piles in sand is described in the following. The purpose for the tests is to examine the tensile capacity of axially loaded piles in dense fully saturated sand. The pile dimensions are chosen to resemble full scale dimension of piles used...... in offshore pile foundations today....

  17. An Unbroken Axial-Vector Current Conservation Law

    Science.gov (United States)

    Sharafiddinov, Rasulkhozha S.

    2016-04-01

    The mass, energy and momentum of the neutrino of a true flavor have an axial-vector nature. As a consequence, the left-handed truly neutral neutrino in an axial-vector field of emission can be converted into a right-handed one and vice versa. This predicts the unidenticality of masses, energies and momenta of neutrinos of the different components. Recognizing such a difference in masses, energies, momenta and accepting that the left-handed axial-vector neutrino and the right-handed antineutrino of true neutrality refer to long-lived C-odd leptons, and the right-handed truly neutral neutrino and the left-handed axial-vector antineutrino are of short-lived fermions of C-oddity, we would write a new CP-even Dirac equation taking into account the flavor symmetrical axial-vector mass, energy and momentum matrices. Their presence explains the spontaneous mirror symmetry violation, confirming that an axial-vector current conservation law has never violated. They reflect the availability of a mirror Minkowski space in which a neutrino is characterized by left as well as by right space-time coordinates. Therefore, it is not surprising that whatever the main purposes experiments about a quasielastic axial-vector mass say in favor of an axial-vector mirror Minkowski space-time.

  18. A new approach to radial and axial gauges

    Science.gov (United States)

    Weigert, Heribert; Heinz, Ulrich

    1992-03-01

    We develop a new path integral formulation of QCD in radial and axial gauges. This formalism yields free propagators which are free of gauge poles. We find that radial gauges are ghost free. In axial gauges ghosts cannot generally be excluded from the formalism due to the need to fix the residual gauge freedom.

  19. Lateral Concepts

    Directory of Open Access Journals (Sweden)

    Christopher Gad

    2016-06-01

    Full Text Available This essay discusses the complex relation between the knowledges and practices of the researcher and his/her informants in terms of lateral concepts. The starting point is that it is not the prerogative of the (STS scholar to conceptualize the world; all our “informants” do it too. This creates the possibility of enriching our own conceptual repertoires by letting them be inflected by the concepts of those we study. In a broad sense, the lateral means that there is a many-to-many relation between domains of knowledge and practice. However, each specific case of the lateral is necessarily immanent to a particular empirical setting and form of inquiry. In this sense lateral concepts are radically empirical since it locates concepts within the field. To clarify the meaning and stakes of lateral concepts, we first make a contrast between lateral anthropology and Latour’s notion of infra-reflexivity. We end with a brief illustration and discussion of how lateral conceptualization can re-orient STS modes of inquiry, and why this matters.

  20. Axial vibration analysis of nanocones based on nonlocal elasticity theory

    Institute of Scientific and Technical Information of China (English)

    Shu-Qi Guo; Shao-Pu Yang

    2012-01-01

    Carbon nanocones have quite fascinating electronic and structural properties,whose axial vibration is seldom investigated in previous studies.In this paper,based on a nonlocal elasticity theory,a nonuniform rod model is applied to investigate the small-scale effect and the nonuniform effect on axial vibration of nanocones.Using the modified Wentzel-Brillouin-Kramers (WBK) method,an asymptotic solution is obtained for the axial vibration of general nonuniform nanorods.Then,using similar procedure,the axial vibration of nanocones is analyzed for nonuniform parameters,mode number and nonlocal parameters.Explicit expressions are derived for mode frequencies of clamped-clamped and clamped-free boundary conditions.It is found that axial vibration frequencies are highly overestimated by the classical rod model because of ignorance of the effect of small length scale.

  1. On Stationary Axially Symmetric Solutions in Brans-Dicke Theory

    CERN Document Server

    Kirezli, Pınar

    2015-01-01

    Stationary axially symmetric Brans-Dicke-Maxwell solutions are re-examined in the framework of the Brans-Dicke theory. We see that, employing a particular parametrization of the standard axially symmetric metric simplifies the procedure of obtaining the Ernst equations for axially symmetric electro-vacuum space-times for this theory. This analysis also permit us to construct a two parameter extension in both Jordan and Einstein frames of an old solution generating technique frequently used to construct axially symmetric solutions for Brans-Dicke theory from a seed solution of General Relativity. As applications of this technique, several known and new solutions are constructed including a general axially symmetric BD-Maxwell solution of Plebanski-Demianski with vanishing cosmological constant, i.e. the Kinnersley solution and general magnetized Kerr-Newman type solutions. Some physical properties and circular motion of test particles for a particular subclass of Kinnersley solution, i.e. Kerr-Newman-NUT type ...

  2. [Intra-articular injections].

    Science.gov (United States)

    Chapelle, Ch

    2015-09-01

    It is not unusual for a specialist or general practitioner to be presented with a pathology which necessitates the use of an intra-articular injection of corticosteroids, hyaluronic acid or a local anaesthetic. It would seem to be interesting to update and to precise the techniques and methods of intraarticular injections which have appeared in recent international publications, when we know that 30 % of the injections given into the knee and so called "dry" are incorrect and, therefore, inefficient. The indication of an articular injection depends, firstly, on the diagnosis which should be done with great care; after which should be an objective analysis complete with secondary effects linked to both the injection and the product used. The conditions of asepsis, the choice of needles and quantities of the injection and even the ways of the injections should be reviewed in detail. The last studies clearly question the secondary effects of the cartilage degradations of the cortisone given as an intra-articular injection and shows its efficiency on the pain and inflammatory phenomonen in osteoarthritis. Studies on hyaluronic acid are often contradictory going from a modest result to an important pain relief but it is necessary to be aware that the objective criteria are difficult to interpret. The use of local anaesthetics in intra-articular is limited by the few indications in view of the major risk of aggravating the pre-existing lesions by the disappearing signs of pain.

  3. Injection of Deuterium Pellets

    DEFF Research Database (Denmark)

    Sørensen, H.; Andersen, P.; Andersen, S. A.

    1984-01-01

    A pellet injection system made for the TFR tokamak at Fontenay-aux-Roses, Paris is described. 0.12-mg pellets are injected with velocities of around 600-700 m/s through a 5-m long guide tube. Some details of a new light gas gun are given; with this gun, hydrogen pellets are accelerated...

  4. Corticotropin, Repository Injection

    Science.gov (United States)

    H.P. Acthar Gel® ... Corticotropin repository injection comes as a long acting gel to inject under the skin or into a ... prescription and nonprescription medications, vitamins, nutritional supplements, or herbal products you are taking or plan to take. ...

  5. Separably injective Banach spaces

    CERN Document Server

    Avilés, Antonio; Castillo, Jesús M F; González, Manuel; Moreno, Yolanda

    2016-01-01

    This monograph contains a detailed exposition of the up-to-date theory of separably injective spaces: new and old results are put into perspective with concrete examples (such as l∞/c0 and C(K) spaces, where K is a finite height compact space or an F-space, ultrapowers of L∞ spaces and spaces of universal disposition). It is no exaggeration to say that the theory of separably injective Banach spaces is strikingly different from that of injective spaces. For instance, separably injective Banach spaces are not necessarily isometric to, or complemented subspaces of, spaces of continuous functions on a compact space. Moreover, in contrast to the scarcity of examples and general results concerning injective spaces, we know of many different types of separably injective spaces and there is a rich theory around them. The monograph is completed with a preparatory chapter on injective spaces, a chapter on higher cardinal versions of separable injectivity and a lively discussion of open problems and further lines o...

  6. Dimethyl Ether Injection Studies

    DEFF Research Database (Denmark)

    Sorenson, Spencer C.; Glensvig, Michael; Abata, Duane L.

    1998-01-01

    effects of DME in high pressure injection have also been observed. DME has a higher compressibility than diesel fuel, resulting in larger pressure oscillations in the injection system during the injection process. The oscillations with DME also have a slower delay rate than those of diesel fuel......A series of preliminary investigations has been performed in order to investigate the behavior of DME in a diesel injection environment. These studies have in-cluded visual observations of the spray penetration and angles for high pressure injection into Nitrogen using conventional jerk pump...... in the same system. As a first attempt to simulate combustion of DME in Diesel engines, the results of the spray studies have been incorporated into a simplified spray combustion model. A turbulent jet structure was adjusted to fit the penetration rates of the observed sprays. The observed spray widths agreed...

  7. Tunable Clamped–Guided Arch Resonators Using Electrostatically Induced Axial Loads

    KAUST Repository

    Alcheikh, Nouha

    2017-01-04

    We present a simulation and experimental investigation of bi-directional tunable in-plane clamped-guided arch microbeam resonators. Tensile and compressive axial forces are generated from a bi-directional electrostatic actuator, which modulates the microbeam stiffness, and hence changes its natural frequency to lower or higher values from its as-fabricated value. Several devices of various anchor designs and geometries are fabricated. We found that for the fabricated shallow arches, the effect of the curvature of the arch is less important compared to the induced axial stress from the axial load. We have shown that the first mode resonance frequency can be increased up to twice its initial value. Additionally, the third mode resonance frequency can be increased up to 30% of its initial value. These results can be promising as a proof-of-concept for the realization of wide-range tunable microresonators. The experimental results have been compared to finite-element simulations, showing good agreement among them.

  8. Computerized axial tomography in clinical pediatrics.

    Science.gov (United States)

    McCullough, D C; Kufta, C; Axelbaum, S P; Schellinger, D

    1977-02-01

    Computerized axial tomography (CAT), a noninvasive radiologie method, provides a new dimension in screening and diagnosis of intracranial pathology. Evaluation of 725 scans in infants and children demonstrates that CAT may be performed with negligible risk, although sedation and restraint are essential to the successful performance of studies in children under 6 years of age. CAT is the preferred initial diagnostic method in suspected hydrocephalls and is accurate in the detection and precise localization of brain tumors. The management of hydrocephalus and brain tumors has been significantly altered by the availability of CAT. Few invasive neuroradiologic procedures are required and pneumography is especially curtailed. Serial scanning is the best available method of monitoring ventricular alterations in hydrocephalus, tumor size during radiotherapy or chemotherapy, and postoperative recurrence of benign neoplasms. Complex intracranial anomalies are detectable with computerized tomography, but complete definition of pathology often requires angiography and air studies. Limited clinical experience in detecting neonatal intraventricular hemorrhage suggests that CAT will be a valuable tool for futlre investigations of that problem.

  9. Multimode interaction in axially excited cylindrical shells

    Directory of Open Access Journals (Sweden)

    Silva F. M. A.

    2014-01-01

    Full Text Available Cylindrical shells exhibit a dense frequency spectrum, especially near the lowest frequency range. In addition, due to the circumferential symmetry, frequencies occur in pairs. So, in the vicinity of the lowest natural frequencies, several equal or nearly equal frequencies may occur, leading to a complex dynamic behavior. So, the aim of the present work is to investigate the dynamic behavior and stability of cylindrical shells under axial forcing with multiple equal or nearly equal natural frequencies. The shell is modelled using the Donnell nonlinear shallow shell theory and the discretized equations of motion are obtained by applying the Galerkin method. For this, a modal solution that takes into account the modal interaction among the relevant modes and the influence of their companion modes (modes with rotational symmetry, which satisfies the boundary and continuity conditions of the shell, is derived. Special attention is given to the 1:1:1:1 internal resonance (four interacting modes. Solving numerically the governing equations of motion and using several tools of nonlinear dynamics, a detailed parametric analysis is conducted to clarify the influence of the internal resonances on the bifurcations, stability boundaries, nonlinear vibration modes and basins of attraction of the structure.

  10. Axially Symmetric Post-Newtonian Stellar Systems

    Directory of Open Access Journals (Sweden)

    Camilo Akímushkin

    2010-06-01

    Full Text Available We introduce a method to obtain self-consistent, axially symmetric disklike stellar models in the first post-Newtonian (1PN approximation. By using in the field equations of the 1PN approximation a distribution function (DF corresponding to a Newtonian model, two fundamental equations determining the 1PN corrections are obtained. The rotation curves of the corrected models differs from the classical ones and the corrections are clearly appreciable with values of the mass and radius of a typical galaxy. On the other hand, the relativistic mass correction can be ignored for all models. Resumen. Presentamos un método para obtener modelos estelares discoidales, axialmente simétricos, auto-consistentes en la primera aproximación post-Newtoniana (1PN. Usando en las ecuaciones de campo de la aproximación 1PN una función de distribución conocida (DF que corresponde a un modelo Newtoniano, se obtienen dos ecuaciones fundamentales para determinar las correcciones 1PN. Las curvas de rotación de los modelos corregidos difieren de las clásicas y las correcciones son claramente apreciables con los valores de la masa y el radio de una galaxia típica. Por otro lado, la corrección relativista de la masa se puede ignorar para todos los modelos.

  11. New treatment targets for axial spondyloarthritis.

    Science.gov (United States)

    Sieper, Joachim

    2016-12-01

    Axial spondyloarthritis (axSpA) patients can be divided into those with structural damage in the SI joint visible on X-rays, termed radiographic axSpA or AS, and those in an earlier phase of the disease, without structural damage in the SI joint, termed non-radiographic axSpA. TNF-blockers have been shown to be highly effective in the treatment of active axSpA. Interestingly, conventional DMARDs and also non-TNF-blocker biologics targeting IL-1, IL-6 and T cells (abatacept) are not effective. Recent interest has focused on the cytokines IL-23 and IL-17 as potential treatment targets in axSpA. An open-label trial with ustekinumab showed a good efficacy in AS patients. Two placebo-controlled phase 3 trials with a mAb blocking IL-17, secukinumab, showed a good reduction in disease activity, similar to that shown for TNF blockers. Probably triggered by inflammation, new bone formation is another hallmark in AS and a potentially important treatment target. However, a previously reported inhibitory effect of NSAID treatment could not be confirmed in a recent NSAID trial.

  12. Vertebrate Axial Patterning: From Egg to Asymmetry.

    Science.gov (United States)

    Houston, Douglas W

    2017-01-01

    The emergence of the bilateral embryonic body axis from a symmetrical egg has been a long-standing question in developmental biology. Historical and modern experiments point to an initial symmetry-breaking event leading to localized Wnt and Nodal growth factor signaling and subsequent induction and formation of a self-regulating dorsal "organizer." This organizer forms at the site of notochord cell internalization and expresses primarily Bone Morphogenetic Protein (BMP) growth factor antagonists that establish a spatiotemporal gradient of BMP signaling across the embryo, directing initial cell differentiation and morphogenesis. Although the basics of this model have been known for some time, many of the molecular and cellular details have only recently been elucidated and the extent that these events remain conserved throughout vertebrate evolution remains unclear. This chapter summarizes historical perspectives as well as recent molecular and genetic advances regarding: (1) the mechanisms that regulate symmetry-breaking in the vertebrate egg and early embryo, (2) the pathways that are activated by these events, in particular the Wnt pathway, and the role of these pathways in the formation and function of the organizer, and (3) how these pathways also mediate anteroposterior patterning and axial morphogenesis. Emphasis is placed on comparative aspects of the egg-to-embryo transition across vertebrates and their evolution. The future prospects for work regarding self-organization and gene regulatory networks in the context of early axis formation are also discussed.

  13. Nitinol stent design - understanding axial buckling.

    Science.gov (United States)

    McGrath, D J; O'Brien, B; Bruzzi, M; McHugh, P E

    2014-12-01

    Nitinol׳s superelastic properties permit self-expanding stents to be crimped without plastic deformation, but its nonlinear properties can contribute towards stent buckling. This study investigates the axial buckling of a prototype tracheobronchial nitinol stent design during crimping, with the objective of eliminating buckling from the design. To capture the stent buckling mechanism a computational model of a radial force test is simulated, where small geometric defects are introduced to remove symmetry and allow buckling to occur. With the buckling mechanism ascertained, a sensitivity study is carried out to examine the effect that the transitional plateau region of the nitinol loading curve has on stent stability. Results of this analysis are then used to redesign the stent and remove buckling. It is found that the transitional plateau region can have a significant effect on the stability of a stent during crimping, and by reducing the amount of transitional material within the stent hinges during loading the stability of a nitinol stent can be increased.

  14. Evaluation of Impinging Stream Vortex Chamber Concepts for Liquid Rocket Engine Applications

    Science.gov (United States)

    Trinh, Huu P.; Bullard, Brad; Kopicz, Charles; Michaels, Scott

    2002-01-01

    To pursue technology developments for future launch vehicles, NASA/Marshall Space Flight Center (MSFC) is examining vortex chamber concepts for liquid rocket engine applications. Past studies indicated that the vortex chamber schemes potentially have a number of advantages over conventional chamber methods. Due to the nature of the vortex flow, relatively cooler propellant streams tend to flow along the chamber wall. Hence, the thruster chamber can be operated without the need of any cooling techniques. This vortex flow also creates strong turbulence, which promotes the propellant mixing process. Consequently, the subject chamber concepts not only offer system simplicity, but also enhance the combustion performance. Test results have shown that chamber performance is markedly high even at a low chamber length-to-diameter ratio (LD). This incentive can be translated to a convenience in the thrust chamber packaging. Variations of the vortex chamber concepts have been introduced in the past few decades. These investigations include an ongoing work at Orbital Technologies Corporation (ORBITEC). By injecting the oxidizer tangentially at the chamber convergence and fuel axially at the chamber head end, Knuth et al. were able to keep the wall relatively cold. A recent investigation of the low L/D vortex chamber concept for gel propellants was conducted by Michaels. He used both triplet (two oxidizer orifices and one fuel orifice) and unlike impinging schemes to inject propellants tangentially along the chamber wall. Michaels called the subject injection scheme an Impinging Stream Vortex Chamber (ISVC). His preliminary tests showed that high performance, with an Isp efficiency of 9295, can be obtained. MSFC and the U. S. Army are jointly investigating an application of the ISVC concept for the cryogenic oxygen/hydrocarbon propellant system. This vortex chamber concept is currently tested with gel propellants at AMCOM at Redstone Arsenal, Alabama. A version of this concept

  15. Análisis de la fuerza axial en un transportador de sinfín // Analysis of axial force in a screw conveyor.

    Directory of Open Access Journals (Sweden)

    F. Aguilar Parés

    1999-01-01

    Full Text Available Durante el movimiento de un material en un transportador de sinfín surge una fuerza en dirección axial que influye en laselección de uno de los cojinetes de apoyo del equipo. En el artículo aparecen algunas soluciones constructivas que tienen encuentan la fuerza axial. Por otro lado se establece la relación entre la fuerza axial y el empuje axial y se precisa de quiendepende el sentido del empuje axial. Por último se propone un modelo matemático que relaciona la fuerza axial con la potenciarequerida por el equipo.Palabras claves: Transportador de sinf in, fuerza axial , empuje axial ._________________________________________________________________________AbstractDuring the movement of material in a screw conveyor surge a force in axial direction that influence in the selection of one ofthe equipment support bearings. Some constructive solutions appear in the article for considering the axial force. In the otherhand it is established the relation between axial force and axial thurst and it is precised whose direction thurst axial depend of.Finally it is proposed a mathematic model that relates the axial force with the power required by the equipment.Key words: Screw conveyor, axial force, axial thurst .

  16. 注射用重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白治疗前后中轴型脊柱关节炎患者血清白细胞介素-23水平和骶髂关节磁共振成像的变化%Change of serum interleukin-23 levels and sacroiliac joint magnetic resonance imaging before and after treatment with recombinant human tumor necrosis factor-α receptor Ⅱ IgG Fc fusion protein for injection in axial spondyloarthritis patients

    Institute of Scientific and Technical Information of China (English)

    苏培培; 米存东; 赵铖; 陈战瑞; 覃芳

    2015-01-01

    Objective We investigated interleukin (IL)-23 that might play a role in the pathogenesis of rheumatoid arthritis (RA) and whether it was correlated with disease activity and clinical manifestations in axial spondyloarthritis (SPA).In addition, the Spondyloarthritis Research Consortium of Canada (SPARCC) scores was used to examine whether recombinant human tumor necrosis factor-α receptor Ⅱ IgG Fc fusion protein for injection (rhTNFR:Fc) was effective for the reduction of magnetic resonance imaging (MRI)-proven sacroiliac joint (SIJ) inflammation.Methods The serum IL-23 levels of etanercept and conven-tional treatment groups were measured using enzyme-linked immunosorbent assay kits.At the same time, SIJ MRI SPARCC score levels were assessed by MRI, the change of clinical indicators of patients was observed.ANOVA, repeated measure data of ANOVA and Spearman's correlation analysis were used for statisical analysis.Results ① The basal serum IL-23 levels of the Etanercept group were (34.2±1.8) pg/ml and those of the conventional treatment group were (34.1 ±1.8) pg/ml (F=1 073.790, P=0.991), both were significantly higher than the healthy control group (18.1±0.8) pg/ml (P=0.005).After treatment, serum IL-23 levels of the rhTNFR: Fc treatment and conventional treatment group were (24.5 ±1.7) pg/ml and (25.2±1.7) pg/ml (F=232.488, P=0.242), (19.2±0.8) pg/ml and (21.6±1.3) pg/ml (F=114.135, P=0.025), (19.0±0.8) pg/ml and(19.4± 0.8) pg/ml (F=23.374, P=0.085) respectively.A significant decrease was observed in the two groups and the serum level of IL-23 of the rhTNFR:Fc group was lower than that of the conventional group at week 12.② SIJ MRI SPARCC scores of the rhTNFR:Fc group and the conventional drugs group were (20.1± 1.2) scores and(20.7±1.5) scores (F=2003.660, P=0.191), (12.5± 0.8) scores and (15.4±0.9) scores (F=1 680.430, P=0.004), (8.8±0.9) scores and (12.8± 0.9) scores (F=972.877, P=0.002), the scores of two group were significantly decreased

  17. Active axial spondyloarthritis: potential role of certolizumab pegol

    Directory of Open Access Journals (Sweden)

    Ranatunga S

    2014-02-01

    Full Text Available Sriya Ranatunga, Anne V Miller Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL, USA Abstract: The axial spondyloarthropathies are a group of chronic inflammatory diseases that predominantly affect the axial joints. This group includes ankylosing spondylitis and nonradiographic axial spondyloarthropathy. While the pathogenesis of axial spondyloarthropathies is not clear, immunologically active tissues primarily include the entheses, ie, the areas where ligaments, tendons, and joint capsules attach to bone and to the annulus fibrosis at the vertebrae. One of the major mediators of the immune response in this group of diseases is tumor necrosis factor-alpha (TNFα. Blockade of TNFα results in reduced vascularity and inflammatory cell infiltration in the synovial tissues of affected joints. Certolizumab pegol (CZP is an Fc-free, PEGylated anti-TNFα monoclonal antibody. CZP has unique properties that differ from other available TNFα inhibitors by virtue of its lack of an Fc region, which minimizes potential Fc-mediated effects, and its PEGylation, which improves drug pharmacokinetics and bioavailability. It has been shown in clinical trials that CZP improves patient outcomes and reduces inflammation in the sacroiliac joints and spine in both ankylosing spondylitis and nonradiographic axial spondyloarthropathies. These data support CZP as a treatment option for axial spondyloarthropathies. Keywords: axial spondyloarthropathy, certolizumab pegol, anti-tumor necrosis factor-alpha, therapy

  18. Axial elongation following prolonged near work in myopes and emmetropes.

    Science.gov (United States)

    Woodman, Emily C; Read, Scott A; Collins, Michael J; Hegarty, Katherine J; Priddle, Scott B; Smith, Josephine M; Perro, Judd V

    2011-05-01

    To investigate the influence of a period of sustained near work upon axial length in groups of emmetropes (EMM) and myopes. Forty young adult subjects (20 myopes and 20 emmetropes) were recruited for the study. Myopes were further classified as early onset (EOM), late onset (LOM), stable (SM) or progressing (PM) subgroups. Axial length was measured with the IOLMaster instrument before, immediately after and then again 10 min after a continuous 30 min near task of 5 D accommodation demand. Measures of distance objective refraction were also collected. Significant changes in axial length were observed immediately following the near task. EOM axial length elongated on average by 0.027±0.021 mm, LOM by 0.014±0.020 mm, EMM by 0.010±0.015 mm, PM by 0.031±0.022 mm and SM by 0.014±0.018 mm. At the conclusion of the 10 min regression period, axial length measures were not significantly different from baseline values. Axial elongation was observed following a prolonged near task. Both EOM and PM groups showed increases in axial length that were significantly greater than emmetropes.

  19. Injection moulding antireflective nanostructures

    DEFF Research Database (Denmark)

    Christiansen, Alexander Bruun; Clausen, Jeppe Sandvik; Mortensen, N. Asger

    in an injection moulding process, to fabricate the antireflective surfaces. The cycle-time was 35 s. The injection moulded structures had a height of 125 nm, and the visible spectrum reflectance of injection moulded black polypropylene surfaces was reduced from 4.5±0.5% to 2.5±0.5%. The gradient of the refractive...... index of the nanostructured surfaces was estimated from atomic force micrographs and the theoretical reflectance was calculated using the transfer matrix method and effective medium theory. The measured reflectance shows good agreement with the theory of graded index antireflective nanostructures...

  20. ALICE Injected Beam Accidents

    CERN Document Server

    Appleby, R B

    2009-01-01

    The ALICE (point 2) interaction region is sensitive to beam orbit errors arising from magnet setting errors on injection. In this report, beam accident scenarios under injection for ALICE are described, focusing on ultra- fast error injection scenarios for the interaction straight correctors and dipoles. Beam 1 and beam 2 accident scenarios are considered, where the errors can lead to beam orbits striking the ALICE vacuum chamber or elements of the machine. The required thresholds for magnet current interlocks are calculated to avoid machine and detector risk.

  1. LHCb Injected Beam Accidents

    CERN Document Server

    Appleby, R B

    2009-01-01

    The LHCb (point 8) interaction region is sensitive to beam orbit errors arising from magnet setting errors on injection. In this report, beam accident scenarios under injection for LHCb are described, focusing on ultra- fast error injection scenarios for the interaction straight correctors and dipoles. Beam 1 and beam 2 accident scenarios are considered, where the errors can lead to beam orbits striking the LHCb vacuum chamber or elements of the machine. The required thresholds for magnet current interlocks are calculated to avoid machine and detector risk.

  2. Fault Injection Techniques and Tools

    Science.gov (United States)

    Hsueh, Mei-Chen; Tsai, Timothy K.; Iyer, Ravishankar K.

    1997-01-01

    Dependability evaluation involves the study of failures and errors. The destructive nature of a crash and long error latency make it difficult to identify the causes of failures in the operational environment. It is particularly hard to recreate a failure scenario for a large, complex system. To identify and understand potential failures, we use an experiment-based approach for studying the dependability of a system. Such an approach is applied not only during the conception and design phases, but also during the prototype and operational phases. To take an experiment-based approach, we must first understand a system's architecture, structure, and behavior. Specifically, we need to know its tolerance for faults and failures, including its built-in detection and recovery mechanisms, and we need specific instruments and tools to inject faults, create failures or errors, and monitor their effects.

  3. Common injections in musculoskeletal medicine.

    Science.gov (United States)

    Monseau, Aaron J; Nizran, Parminder Singh

    2013-12-01

    Musculoskeletal injections are a common procedure in primary care and sports medicine but can be intimidating for some clinicians. This article addresses current evidence for corticosteroid injections, and common injection indications and techniques, namely knee, subacromial bursa, glenohumeral joint, lateral epicondyle, de Quervain tenosynovitis, and greater trochanteric bursa injections. Preparation for injections and some evidence for ultrasound guidance are also reviewed.

  4. A Comparison of Combustion Dynamics for Multiple 7-Point Lean Direct Injection Combustor Configurations

    Science.gov (United States)

    Tacina, K. M.; Hicks, Y. R.

    2017-01-01

    The combustion dynamics of multiple 7-point lean direct injection (LDI) combustor configurations are compared. LDI is a fuel-lean combustor concept for aero gas turbine engines in which multiple small fuel-air mixers replace one traditionally-sized fuel-air mixer. This 7-point LDI configuration has a circular cross section, with a center (pilot) fuel-air mixer surrounded by six outer (main) fuel-air mixers. Each fuel-air mixer consists of an axial air swirler followed by a converging-diverging venturi. A simplex fuel injector is inserted through the center of the air swirler, with the fuel injector tip located near the venturi throat. All 7 fuel-air mixers are identical except for the swirler blade angle, which varies with the configuration. Testing was done in a 5-atm flame tube with inlet air temperatures from 600 to 800 F and equivalence ratios from 0.4 to 0.7. Combustion dynamics were measured using a cooled PCB pressure transducer flush-mounted in the wall of the combustor test section.

  5. Tensile Property of Bi-axial Warp Knitted Structure

    Institute of Scientific and Technical Information of China (English)

    沈为

    2003-01-01

    The tensile property of bi-axial warp knitted fabrics is tested and compared with that of the plain weave fabric. The results show that there are obvious differences between the tensile property of a bi-axial warp knitted fabric and that of a plain weave fabric.The former can give fuller play to the property of a high modulus yarn than the latter. The tensile strength of a bi-axial warp knitted fabric is linear with the number of yarns in the direction of force.

  6. The axial charges of the hidden-charm pentaquark states

    CERN Document Server

    Wang, Guang-Juan; Zhu, Shi-Lin

    2016-01-01

    With the chiral quark model, we have calculated the axial charges of the pentaquark states with $(I,I_3)=(\\frac{1}{2},\\frac{1}{2})$ and $J^{P}=\\frac{1}{2}^{\\pm},\\frac{3}{2}^{\\pm},\\frac{5}{2}^{\\pm}$. The $P_c$ states with the same $J^P$ quantum numbers but different color-spin-flavor configurations have very different axial charges, which encode important information on their underlying structures. For some of the $J^{P}=\\frac{3}{2}^{\\pm}$ or $\\frac{5}{2}^{\\pm}$ pentaquark states, their axial charges are much smaller than that of the proton.

  7. Dynamic Analysis of Axial Magnetic Forces for DVD Spindle Motors

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The axial magnetic force, induced by the complicated flux linkage distribution from rotor magnet and stator slotted, is constructed by different relative heights and calculated by 3D finite element method (FEM) to analyze the dynamic characteristics for a DVD spindle motor. The axial magnetic force is designed to provide an axial stiffness and govern the natural frequency of the dynamic performance. According to the simulation results and experimental measurements, the dynamic behaviors are significantly improved with a variation of relative height of rotor magnet and stator slotted on a DVD spindle motor.

  8. Gravitational waves from the axial perturbations of hyperon stars

    Institute of Scientific and Technical Information of China (English)

    Wen De-Hua; Yan Jing; Liu Xue-Mei

    2012-01-01

    The eigen-frequencies of the axial w-mode oscillations of hyperon stars are examined.It is shown that as the appearance of hyperons softens the equation of state of the super-density matter,the frequency of gravitational waves from the axial w-mode of hyperon star becomes smaller than that of a traditional neutron star at the same stellar mass.Moreover,the eigenfrequencies of hyperon stars also have scaling universality.It is shown that the EURO thirdgeneration gravitational-wave detector has the potential to detect the gravitational-wave signal emitted from the axial w-mode oscillations of a hyperon star.

  9. Dispositivos de asistencia ventricular de tipo axial

    Directory of Open Access Journals (Sweden)

    Albert Miralles Cassina

    2009-04-01

    Full Text Available El uso de dispositivos de asistencia ventricular se ha ido extendiendo en las últimas décadas. La mejora de los resultados ha ido acompañada del diseño de nuevos aparatos más pequeños y eficientes como son las bombas de flujo axial. las características técnicas básicas de estos dispositivos se hallan en la generación de un flujo continuo unidireccional conseguido mediante sistemas de turbina que obtienen su alimentación de una fuente eléctrica. Las ventajas principales de estos dispositivos son: su facilidad de implantación por su tamaño reducido, su prolongada durabilidad gracias a su sencillo diseño y su eficiencia energética al utilizar energía eléctrica. Su utilidad se ha podido demostrar en diferentes indicaciones de asistencia circulatoria mecánica, como en el caso de puente al trasplante o dispositivo de recuperación miocárdica, si bien donde radica más interés es en su uso como sistemas de asistencia circulatoria mecánica definitiva. Existe una variedad de modelos de diversos diseños. Son dispositivos que permiten soporte normalmente univentricular izquierdo, que se implantan en el tórax con cánula de entrada a nivel ventricular y cánula de salida a nivel aórtico. En este artículo se efectúa una descripción de los principales sistemas disponibles en la actualidad, comentando las características técnicas, ventajas e inconvenientes y un resumen de la experiencia existente.

  10. Revealing atropisomer axial chirality in drug discovery.

    Science.gov (United States)

    LaPlante, Steven R; Edwards, Paul J; Fader, Lee D; Jakalian, Araz; Hucke, Oliver

    2011-03-07

    An often overlooked source of chirality is atropisomerism, which results from slow rotation along a bond axis due to steric hindrance and/or electronic factors. If undetected or not managed properly, this time-dependent chirality has the potential to lead to serious consequences, because atropisomers can be present as distinct enantiomers or diastereoisomers with their attendant different properties. Herein we introduce a strategy to reveal and classify compounds that have atropisomeric chirality. Energy barriers to axial rotation were calculated using quantum mechanics, from which predicted high barriers could be experimentally validated. A calculated rotational energy barrier of 20 kcal mol(-1) was established as a suitable threshold to distinguish between atropisomers and non-atropisomers with a prediction accuracy of 86%. This methodology was applied to subsets of drug databases in the course of which atropisomeric drugs were identified. In addition, some drugs were exposed that were not yet known to have this chiral attribute. The most valuable utility of this tool will be to predict atropisomerism along the drug discovery pathway. When used in concert with our compound classification scheme, decisions can be made during early discovery stages such as "hit-to-lead" and "lead optimization," to foresee and validate the presence of atropisomers and to exercise options of removing, further stabilizing, or rendering the chiral axis of interest more freely rotatable via SAR design, thereby decreasing this potential liability within a compound series. The strategy can also improve drug development plans, such as determining whether a drug or series should be developed as a racemic mixture or as an isolated single compound. Moreover, the work described herein can be extended to other chemical fields that require the assessment of potential chiral axes.

  11. Demonstration of steady inductive helicity injection

    Science.gov (United States)

    Sieck, P. E.; Jarboe, T. R.; Izzo, V. A.; Hamp, W. T.; Nelson, B. A.; O'Neill, R. G.; Redd, A. J.; Smith, R. J.

    2006-02-01

    Initial results demonstrating the concept of constant inductive helicity injection are presented. Constant helicity injection is achieved using two oscillating inductive helicity injectors, with the goal of producing a bow tie spheromak. Each injector is a 180° segment of a reverse field pinch and they are driven 90° out of phase. Approximately 5 MW of power is injected during the 6 ms pulse, and the input power has been maintained at a fairly constant value by directly fuelling the injectors with neutral gas. Motivation for the experiment is given, including beta-limit calculations for the bow tie spheromak. Fuelling the injectors with neutral gas during the discharge is shown to produce injector parameters that are more constant in time. A series of discharges with increasing power input shows a promising increase in toroidal current. Unique construction techniques of the experiment are also described.

  12. Astrophysical Concepts

    CERN Document Server

    Harwit, Martin

    2006-01-01

    This classic text, aimed at senior undergraduates and beginning graduate students in physics and astronomy, presents a wide range of astrophysical concepts in sufficient depth to give the reader a quantitative understanding of the subject. Emphasizing physical concepts, the book outlines cosmic events but does not portray them in detail: it provides a series of astrophysical sketches. For this fourth edition, nearly every part of the text has been reconsidered and rewritten, new sections have been added to cover recent developments, and others have been extensively revised and brought up to date. The book begins with an outline of the scope of modern astrophysics and enumerates some of the outstanding problems faced in the field today. The basic physics needed to tackle these questions are developed in the next few chapters using specific astronomical processes as examples. The second half of the book enlarges on these topics and shows how we can obtain quantitative insight into the structure and evolution of...

  13. The Design Method of Axial Flow Runners Focusing on Axial Flow Velocity Uniformization and Its Application to an Ultra-Small Axial Flow Hydraulic Turbine

    Directory of Open Access Journals (Sweden)

    Yasuyuki Nishi

    2016-01-01

    Full Text Available We proposed a portable and ultra-small axial flow hydraulic turbine that can generate electric power comparatively easily using the low head of open channels such as existing pipe conduits or small rivers. In addition, we proposed a simple design method for axial flow runners in combination with the conventional one-dimensional design method and the design method of axial flow velocity uniformization, with the support of three-dimensional flow analysis. Applying our design method to the runner of an ultra-small axial flow hydraulic turbine, the performance and internal flow of the designed runner were investigated using CFD analysis and experiment (performance test and PIV measurement. As a result, the runners designed with our design method were significantly improved in turbine efficiency compared to the original runner. Specifically, in the experiment, a new design of the runner achieved a turbine efficiency of 0.768. This reason was that the axial component of absolute velocity of the new design of the runner was relatively uniform at the runner outlet in comparison with that of the original runner, and as a result, the negative rotational flow was improved. Thus, the validity of our design method has been verified.

  14. Mouse bladder wall injection.

    Science.gov (United States)

    Fu, Chi-Ling; Apelo, Charity A; Torres, Baldemar; Thai, Kim H; Hsieh, Michael H

    2011-07-12

    Mouse bladder wall injection is a useful technique to orthotopically study bladder phenomena, including stem cell, smooth muscle, and cancer biology. Before starting injections, the surgical area must be cleaned with soap and water and antiseptic solution. Surgical equipment must be sterilized before use and between each animal. Each mouse is placed under inhaled isoflurane anesthesia (2-5% for induction, 1-3% for maintenance) and its bladder exposed by making a midline abdominal incision with scissors. If the bladder is full, it is partially decompressed by gentle squeezing between two fingers. The cell suspension of interest is intramurally injected into the wall of the bladder dome using a 29 or 30 gauge needle and 1 cc or smaller syringe. The wound is then closed using wound clips and the mouse allowed to recover on a warming pad. Bladder wall injection is a delicate microsurgical technique that can be mastered with practice.

  15. IncobotulinumtoxinA Injection

    Science.gov (United States)

    ... injected into a muscle, it blocks the nerve signals that cause uncontrollable tightening and movements of the ... any of these symptoms, do not drive a car, operate machinery, or do other dangerous activities.if ...

  16. Amphotericin B Liposomal Injection

    Science.gov (United States)

    ... lining of the spinal cord and brain) and visceral leishmaniasis (a parasitic disease that usually affects spleen, ... complex injection: fever, chills, nausea, vomiting, flushing, back pain with or without chest tightness, chest pain, shortness ...

  17. PS injection area

    CERN Multimedia

    1974-01-01

    To the right is the PS ring viewed along the direction of the protons. At the left the injection line coming from the 50 MeV Linac 1 (bottom) and going towards the 800 MeV booster, or deflected to the right to be injected directly into straight section 16. The drumlike element behind the (blue) dipole magnet is a 'debuncher' (a 200 MHz cavity). See photos 7409014X and 7409009.

  18. Injection and Dump Systems

    CERN Document Server

    Bracco, C; Barnes, M J; Carlier, E; Drosdal, L N; Goddard, B; Kain, V; Meddahi, M; Mertens, V; Uythoven, J

    2012-01-01

    Performance and failures of the LHC injection and ex- traction systems are presented. In particular, a comparison with the 2010 run, lessons learnt during operation with high intensity beams and foreseen upgrades are described. UFOs, vacuum and impedance problems related to the injection and extraction equipment are analysed together with possible improvements and solutions. New implemented features, diagnostics, critical issues of XPOC and IQC applications are addressed.

  19. Optimizing Power Density and Efficiency of a Double-Halbach Array Permanent-Magnet Ironless Axial-Flux Motor

    Science.gov (United States)

    Duffy, Kirsten P.

    2016-01-01

    NASA Glenn Research Center is investigating hybrid electric and turboelectric propulsion concepts for future aircraft to reduce fuel burn, emissions, and noise. Systems studies show that the weight and efficiency of the electric system components need to be improved for this concept to be feasible. This effort aims to identify design parameters that affect power density and efficiency for a double-Halbach array permanent-magnet ironless axial flux motor configuration. These parameters include both geometrical and higher-order parameters, including pole count, rotor speed, current density, and geometries of the magnets, windings, and air gap.

  20. The Nonradiographic Axial Spondyloarthritis, the Radiographic Axial Spondyloarthritis, and Ankylosing Spondylitis: The Tangled Skein of Rheumatology

    Science.gov (United States)

    Rawat, Roopa; Agrawal, Neha; Patil, Nilesh S.

    2017-01-01

    Since 1984 the diagnosis of ankylosing spondylitis (AS) has been based upon the modified New York (mNY) criteria with mandatory presence of radiographic sacroiliitis, without which the diagnosis is not tenable. However, it may take years or decades for radiographic sacroiliitis to develop delaying the diagnosis for long periods. It did not matter in the past because no effective treatment was available. However, with the availability of a highly effective treatment, namely, tumour necrosis factor-α inhibitors (TNFi), the issue of early diagnosis of AS acquired an urgency. The Assessment of SpondyloArthritis International Society (ASAS) classification criteria published in 2009 was a significant step towards this goal. These criteria described an early stage of the disease where sacroiliitis was demonstrable only on MRI but not on standard radiograph. Therefore, this stage of the disease was labelled “nonradiographic axial SpA” (nr-axSpA). But questions have been raised if, in search of early diagnosis, specificity was compromised. The Federal Drug Administration (FDA, USA) withheld approval for the use of TNFi in patients with nr-axSpA because of issues related to the specificity of these criteria. This review attempts to clarify some of these aspects of the nr-axSpA-AS relationship and also tries to answer the question whether ASAS classifiable radiographic axial spondyloarthritis (r-axSpA) term can be interchangeably used with the term AS. PMID:28555158

  1. Injectable biphasic calcium phosphate bioceramic: The HYDROS concept.

    Science.gov (United States)

    Baroth, Serge; Bourges, Xavier; Goyenvalle, Eric; Aguado, Eric; Daculsi, Guy

    2009-01-01

    A new biphasic calcium phosphate ceramic material has been developed in our laboratory. It is composed of 60% of hydroxyapatite and 40% of beta-tricalcium phosphate, based on three granulometries (submicron, round microporous 80-200 mum and macro microporous 0.5-1 mm particles) and hydrated with water leading the formation of a putty filler for bone repair. Biocompatibility and osteogenicity were tested by filling femoral epiphyses critical size bone defect and lumbar muscles in rabbit. After 3, 6 and 12 weeks of implantation, explants were treated for histology. Results revealed the biocompatibility of the material and intensive resorption of the submicron particle fraction followed by important bone ingrowth whereas osteoconduction was provided by the larger particles.

  2. Radial breathing mode of carbon nanotubes subjected to axial pressure.

    Science.gov (United States)

    Lei, Xiao-Wen; Ni, Qing-Qing; Shi, Jin-Xing; Natsuki, Toshiaki

    2011-08-11

    In this paper, a theoretical analysis of the radial breathing mode (RBM) of carbon nanotubes (CNTs) subjected to axial pressure is presented based on an elastic continuum model. Single-walled carbon nanotubes (SWCNTs) are described as an individual elastic shell and double-walled carbon nanotubes (DWCNTs) are considered to be two shells coupled through the van der Waals force. The effects of axial pressure, wave numbers and nanotube diameter on the RBM frequency are investigated in detail. The validity of these theoretical results is confirmed through the comparison of the experiment, calculation and simulation. Our results show that the RBM frequency is linearly dependent on the axial pressure and is affected by the wave numbers. We concluded that RBM frequency can be used to characterize the axial pressure acting on both ends of a CNT.

  3. The geometrical theory of diffraction for axially symmetric reflectors

    DEFF Research Database (Denmark)

    Rusch, W.; Sørensen, O.

    1975-01-01

    The geometrical theory of diffraction (GTD) (cf. [1], for example) may be applied advantageously to many axially symmetric reflector antenna geometries. The material in this communication presents analytical, computational, and experimental results for commonly encountered reflector geometries...

  4. Time Domain Terahertz Axial Computed Tomography Non Destructive Evaluation Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to demonstrate key elements of feasibility for a high speed automated time domain terahertz computed axial tomography (TD-THz CT) non destructive...

  5. ANALYSIS OF PULSATILE BLOOD FLOW IN AXIALLY MOVING ARTERIES

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    In order to study motional properties of pulsatile blood flow in axially moving arteries, the authors derived some expressions of the pulsatile blood flow from the basic equations of motion for blood and vascular walls, including an axial blood velocity equation, a flow rate equation and a wall shear stress equation, which described not only the overall axial movement of the arteries but also the elastic properties of the vascular walls, discussed the effects of the arterial wall elasticity on the wall shear stress in coronary arteries in terms of these expressions, and analyzed changes of motional properties of pulsatile blood flow between an elastic arterial tube model and a rigid tube model. The results proved the inference by J.E. Moore Jr. et al. (1994) that the axial movement of arteries be as important in determining coronary artery hemodynamics as the elastic property of the vascular wall.

  6. Open-Axial-Field Magnet at ISR intersection I8

    CERN Multimedia

    1979-01-01

    This axial field spectrometer left the central collision region unobstructed in order to ease analysis of secondary particles emitted at large angle. The ISR circulating beams were passing through a hole in the magnet poles.

  7. Axial mesodermal dysplasia complex: a new case with parental consanguinity.

    Science.gov (United States)

    Mota, C R; Azevedo, M; Rocha, G; Manuela, F; Coelho, R; Lima, M R

    2000-01-01

    A female is described with axial mesodermal dysplasia complex (AMDC) born to a consanguineous couple. This is thought to be the first description of a patient with AMDC born to consanguineous parents.

  8. Axial Stringy System of the Kerr Spinning Particle

    CERN Document Server

    Burinskii, A

    2004-01-01

    The structure of classical spinning particle based on the Kerr-Newman black hole (BH) solution is investigated. For large angular momentum, $|a|>>m$, the BH horizons disappear exposing a naked ringlike source which is a circular relativistic string. It was shown recently that electromagnetic excitations of this string lead to the appearance of an extra axial stringy system which consists of two half-infinite strings of opposite chirality. In this paper we consider the relation of this stringy system to the Dirac equation. We also show that the axial strings are the Witten superconducting strings and describe their structure by the Higgs field model where the Higgs condensate is used to regularize axial singularity. We argue that this axial stringy system may play the role of a classical carrier of the wave function.

  9. Time Domain Terahertz Axial Computed Tomography Non Destructive Evaluation Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In this Phase 2 project, we propose to develop, construct, and deliver to NASA a computed axial tomography time-domain terahertz (CT TD-THz) non destructive...

  10. Uniform Decay for Solutions of an Axially Moving Viscoelastic Beam

    Energy Technology Data Exchange (ETDEWEB)

    Kelleche, Abdelkarim, E-mail: kellecheabdelkarim@gmail.com [Université des Sciences et de la Technologie Houari Boumediene, Faculté des Mathématiques (Algeria); Tatar, Nasser-eddine, E-mail: tatarn@Kfupm.edu.sa [King Fahd University of Petroleum and Minerals, Department of Mathematics and Statistics (Saudi Arabia)

    2017-06-15

    The paper deals with an axially moving viscoelastic structure modeled as an Euler–Bernoulli beam. The aim is to suppress the transversal displacement (transversal vibrations) that occur during the axial motion of the beam. It is assumed that the beam is moving with a constant axial speed and it is subject to a nonlinear force at the right boundary. We prove that when the axial speed of the beam is smaller than a critical value, the dissipation produced by the viscoelastic material is sufficient to suppress the transversal vibrations. It is shown that the rate of decay of the energy depends on the kernel which arise in the viscoelastic term. We consider a general kernel and notice that solutions cannot decay faster than the kernel.

  11. Reduction of Altitude Diffuser Jet Noise Using Water Injection

    Science.gov (United States)

    Allgood, Daniel C.; Saunders, Grady P.; Langford, Lester A.

    2011-01-01

    A feasibility study on the effects of injecting water into the exhaust plume of an altitude rocket diffuser for the purpose of reducing the far-field acoustic noise has been performed. Water injection design parameters such as axial placement, angle of injection, diameter of injectors, and mass flow rate of water have been systematically varied during the operation of a subscale altitude test facility. The changes in acoustic far-field noise were measured with an array of free-field microphones in order to quantify the effects of the water injection on overall sound pressure level spectra and directivity. The results showed significant reductions in noise levels were possible with optimum conditions corresponding to water injection at or just upstream of the exit plane of the diffuser. Increasing the angle and mass flow rate of water injection also showed improvements in noise reduction. However, a limit on the maximum water flow rate existed as too large of flow rate could result in un-starting the supersonic diffuser.

  12. Reduction of Altitude Diffuser Jet Noise Using Water Injection

    Science.gov (United States)

    Allgood, Daniel C.; Saunders, Grady P.; Langford, Lester A.

    2014-01-01

    A feasibility study on the effects of injecting water into the exhaust plume of an altitude rocket diffuser for the purpose of reducing the far-field acoustic noise has been performed. Water injection design parameters such as axial placement, angle of injection, diameter of injectors, and mass flow rate of water have been systematically varied during the operation of a subscale altitude test facility. The changes in acoustic far-field noise were measured with an array of free-field microphones in order to quantify the effects of the water injection on overall sound pressure level spectra and directivity. The results showed significant reductions in noise levels were possible with optimum conditions corresponding to water injection at or just upstream of the exit plane of the diffuser. Increasing the angle and mass flow rate of water injection also showed improvements in noise reduction. However, a limit on the maximum water flow rate existed as too large of flow rate could result in un-starting the supersonic diffuser.

  13. Theoretical prediction of regression rates in swirl-injection hybrid rocket engines

    Science.gov (United States)

    Ozawa, K.; Shimada, T.

    2016-07-01

    The authors theoretically and analytically predict what times regression rates of swirl injection hybrid rocket engines increase higher than the axial injection ones by estimating heat flux from boundary layer combustion to the fuel port. The schematic of engines is assumed as ones whose oxidizer is injected from the opposite side of the nozzle such as ones of Yuasa et al. propose. To simplify the estimation, we assume some hypotheses such as three-dimensional (3D) axisymmetric flows have been assumed. The results of this prediction method are largely consistent with Yuasa's experiments data in the range of high swirl numbers.

  14. Axial Anomaly in Lattice Abelian Gauge Theory in Arbitrary Dimensions

    CERN Document Server

    Fujiwara, T; Wu, K; Fujiwara, Takanori; Suzuki, Hiroshi; Wu, Ke

    1999-01-01

    Axial anomaly of lattice abelian gauge theory in hyper-cubic regular lattice in arbitrary even dimensions is investigated by applying the method of exterior differential calculus. The topological invariance, gauge invariance and locality of the axial anomaly determine the explicit form of the topological part. The anomaly is obtained up to a multiplicative constant for finite lattice spacing and can be interpreted as the Chern character of the abelian lattice gauge theory.

  15. Axially symmetric volume constrained anisotropic mean curvature flow

    CERN Document Server

    Palmer, Bennett

    2011-01-01

    We study the long time existence theory for a non local flow associated to a free boundary problem for a trapped non liquid drop. The drop has free boundary components on two horizontal plates and its free energy is anisotropic and axially symmetric. For axially symmetric initial surfaces with sufficiently large volume, we show that the flow exists for all time. Numerical simulations of the curvature flow are presented.

  16. Axial myopia in computed and magnetic resonance tomography

    Energy Technology Data Exchange (ETDEWEB)

    Beyer-Enke, S.A.; Goerich, J.; Gamroth, A.

    1987-08-01

    The case of a 44-year old woman suffering from amblyopia on the left eye with unilateral proptosis caused by axial (progressive) myopia is presented. The clinical and radiological findings were discussed in reference to the literature. The diagnosis was established by ruling out neoplastic, inflammatory or endocrine causes for the exophtalmos. CT and MR scans revealed an enlarged left globe without evidence of orbital masses. The findings were regarded as typical for the diagnosis at axial myopia.

  17. Watson's theorem and the $N\\Delta(1232)$ axial transition

    CERN Document Server

    Alvarez-Ruso, L; Nieves, J; Vacas, M J Vicente

    2016-01-01

    We present a new determination of the $N\\Delta$ axial form factors from neutrino induced pion production data. For this purpose, the model of Hernandez et al., Phys. Rev. D76, 033005 (2007) is improved by partially restoring unitarity. This is accomplished by imposing Watson's theorem on the dominant vector and axial multipoles. As a consequence, a larger $C_5^A(0)$, in good agreement with the prediction from the off-diagonal Goldberger-Treiman relation, is now obtained.

  18. Method to Measure Tone of Axial and Proximal Muscle

    OpenAIRE

    2011-01-01

    The control of tonic muscular activity remains poorly understood. While abnormal tone is commonly assessed clinically by measuring the passive resistance of relaxed limbs1, no systems are available to study tonic muscle control in a natural, active state of antigravity support. We have developed a device (Twister) to study tonic regulation of axial and proximal muscles during active postural maintenance (i.e. postural tone). Twister rotates axial body regions relative to each other about the ...

  19. Axially astigmatic surfaces: different types and their properties

    Science.gov (United States)

    Malacara-Doblado, Daniel; Malacara-Hernandez, Daniel; Garcia-Marquez, Jorge L.

    1996-12-01

    Axially astigmatic surfaces have different curvatures in orthogonal diameters. Toroidal and spherocylindrical optical surfaces are two mathematically different special cases of axially astigmatic surfaces as noted by Menchaca and Malacara (1986), but they are almost identical in the vicinity of the optical axis. The different between these two surfaces increases when the distance to the optical axis increases. We study the general properties of astigmatic surfaces and some special interesting cases.

  20. Axial blanket for 16NGF Angra 1 fuel type

    Energy Technology Data Exchange (ETDEWEB)

    Sadde, Luciano Martins; Faria, Eduardo Fernandes [Industrias Nucleares do Brasil (INB), Resende, RJ (Brazil)]. E-mails: sadde@inb.gov.br; faria@inb.gov.br; Sang-Keun You [Korea Nuclear Fuel Co. Ltd. (KNFC), Taejon (Korea, Republic of)]. E-mail: skyou@knfc.co.kr

    2007-07-01

    Angra-1, Kori-2 and Krsko are nuclear power plants with the same design. However, the fuel assemblies have some differences in design due to the countries strategies and the differences in the fabrication process. The 16NGF (16x16 Next Generation Fuel) was developed by INB, KNFC and Westinghouse in order to be used in these three nuclear power plants and the 'Axial Blanket' is one of the new features for the 16NGF design. The main purpose of the Axial Blanket Optimization study is to determine which axial blanket enrichment and length would provide the better fuel cycle cost benefit. All of the calculations were performed using Gadolinium as Burnable Absorber and solid pellets type for Axial Blanket. The results indicate 1.8 w/o U235 enrichment and 8 inches length as the best option of Axial Blanket from the fuel cycle cost benefit standpoint. The economy is about 1.8%. The difference in the reload cost in the range between 1.5 and 2.6 w/o U235 enrichment and for the 6 and 8 inches length is not so significant. Due that, from the Fq limit standpoint and also for longer cycle length requirements, a higher axial blanket enrichment (2.6 w/o) and shorter length (6 inches) is recommended. (author)

  1. Reactive control of subsonic axial fan noise in a duct.

    Science.gov (United States)

    Liu, Y; Choy, Y S; Huang, L; Cheng, L

    2014-10-01

    Suppressing the ducted fan noise at low frequencies without varying the flow capacity is still a technical challenge. This study examines a conceived device consisting of two tensioned membranes backed with cavities housing the axial fan for suppression of the sound radiation from the axial fan directly. The noise suppression is achieved by destructive interference between the sound fields from the axial fan of a dipole nature and sound radiation from the membrane via vibroacoustics coupling. A two-dimensional model with the flow effect is presented which allows the performance of the device to be explored analytically. The air flow influences the symmetrical behavior and excites the odd in vacuo mode response of the membrane due to kinematic coupling. Such an asymmetrical effect can be compromised with off-center alignment of the axial fan. Tension plays an important role to sustain the performance to revoke the deformation of the membrane during the axial fan operation. With the design of four appropriately tensioned membranes covered by a cylindrical cavity, the first and second blade passage frequencies of the axial fan can be reduced by at least 20 dB. The satisfactory agreement between experiment and theory demonstrates that its feasibility is practical.

  2. Slow axial drift in three-dimensional granular tumbler flow

    Science.gov (United States)

    Zaman, Zafir; D'Ortona, Umberto; Umbanhowar, Paul B.; Ottino, Julio M.; Lueptow, Richard M.

    2013-07-01

    Models of monodisperse particle flow in partially filled three-dimensional tumblers often assume that flow along the axis of rotation is negligible. We test this assumption, for spherical and double cone tumblers, using experiments and discrete element method simulations. Cross sections through the particle bed of a spherical tumbler show that, after a few rotations, a colored band of particles initially perpendicular to the axis of rotation deforms: particles near the surface drift toward the pole, while particles deeper in the flowing layer drift toward the equator. Tracking of mm-sized surface particles in tumblers with diameters of 8-14 cm shows particle axial displacements of one to two particle diameters, corresponding to axial drift that is 1-3% of the tumbler diameter, per pass through the flowing layer. The surface axial drift in both double cone and spherical tumblers is zero at the equator, increases moving away from the equator, and then decreases near the poles. Comparing results for the two tumbler geometries shows that wall slope causes axial drift, while drift speed increases with equatorial diameter. The dependence of axial drift on axial position for each tumbler geometry is similar when both are normalized by their respective maximum values.

  3. Axial scanning in confocal microscopy employing adaptive lenses (CAL).

    Science.gov (United States)

    Koukourakis, Nektarios; Finkeldey, Markus; Stürmer, Moritz; Leithold, Christoph; Gerhardt, Nils C; Hofmann, Martin R; Wallrabe, Ulrike; Czarske, Jürgen W; Fischer, Andreas

    2014-03-10

    In this paper we analyze the capability of adaptive lenses to replace mechanical axial scanning in confocal microscopy. The adaptive approach promises to achieve high scan rates in a rather simple implementation. This may open up new applications in biomedical imaging or surface analysis in micro- and nanoelectronics, where currently the axial scan rates and the flexibility at the scan process are the limiting factors. The results show that fast and adaptive axial scanning is possible using electrically tunable lenses but the performance degrades during the scan. This is due to defocus and spherical aberrations introduced to the system by tuning of the adaptive lens. These detune the observation plane away from the best focus which strongly deteriorates the axial resolution by a factor of ~2.4. Introducing balancing aberrations allows addressing these influences. The presented approach is based on the employment of a second adaptive lens, located in the detection path. It enables shifting the observation plane back to the best focus position and thus creating axial scans with homogeneous axial resolution. We present simulated and experimental proof-of-principle results.

  4. Relationship Between Retinal Vein Occlusion and Axial Length

    Directory of Open Access Journals (Sweden)

    San-Chang Tsai

    2003-09-01

    Full Text Available This study examined whether axial length is a local risk factor for central retinal vein occlusion (CRVO and branch retinal vein occlusion (BRVO. The study group consisted of 40 patients with unilateral CRVO and 77 patients with unilateral BRVO. The control group included 67 individuals who matched the study group patients in age, systemic hypertension, and diabetes mellitus status. The axial lengths of affected and fellow eyes of patients and controls were measured using A-scan ultrasonography. The axial length of affected eyes was statistically significantly shorter than that of unaffected eyes in the BRVO group (p < 0.05 but not in the CRVO group (p = 0.05. There were also statistically significant differences in axial length between control eyes and affected eyes in both the CRVO group (p < 0.05 and BRVO group (p < 0.05. Thus, shorter axial length could be a risk factor for developing CRVO and BRVO. The axial lengths of affected eyes in retinal vein occlusion patients tend to be shorter than those of unaffected eyes, especially in BRVO patients.

  5. Axial design of nuclear fuel using path relinking; Diseno axial de combustible nuclear utilizando path relinking

    Energy Technology Data Exchange (ETDEWEB)

    Castillo, A.; Torres, M.; Ortiz, J. J.; Perusquia, R.; Hernandez, J. L.; Montes, J. L. [ININ, 52750 La Marquesa, Estado de Mexico (Mexico)]. e-mail: jacm@nuclear.inin.mx

    2008-07-01

    In the present work the preliminary results were obtained with the zoctli system whose purpose is the axial design of assembly of nuclear fuel under certain considerations. For the mentioned design well-know cells were already used and that they have been proven in diverse cycles of operation in the nuclear power plant of Laguna Verde. The design contemplates fuels assemblies of 10x10 and with 2 water channels. The assembly was distributed in 6 axial zones according to its structure. In order to take to end the optimization is was used the well-known technique like Path relinking and to find the group of previous solutions required by this technique uses the technical Taboo search. In order to work with Path relinking, 5 trajectories was taken in to account from a set of 5 previous solutions generated with theTaboo search, the update of the group of solutions is carried out in dynamic form. In the case of the Taboo search it was used a list of variable size, it was implement an aspiration approach, it was used the vector of frequencies and due to the cost of the evaluation of the objective function, only it was review 5% of the vicinity. For the objective function was considered the limit thermal, the axial profile of power, the effective multiplication factor and the margin of having turned off in cold. In order to prove the design system, it was used a balance cycle with a value of reference of 0.9928 for the effective multiplication factor that is equivalent to a produced energy of 10896 MWd/TU at the end of operation to full power. The designed assemblies were placed both in one of lots different from fresh assemblies on which it counts the referred cycle. At the end one a comparison with the results obtained with other techniques and under similar conditions is made. The results obtained until the moment show an appropriate performance of the system. It is possible to indicate that a small inconvenient is the amount of consumed resources of calculation during

  6. Lighten up: Specific postural instructions affect axial rigidity and step initiation in patients with Parkinson’s disease

    Science.gov (United States)

    Cohen, Rajal G.; Gurfinkel, Victor S.; Kwak, Elizabeth; Warden, Amelia C.; Horak, Fay B.

    2015-01-01

    Background Parkinson’s disease (PD) is associated with stooped postural alignment, increased postural sway, and reduced mobility. The Alexander Technique (AT) is a mindfulness-based approach to improving posture and mobility by reducing muscular interference while maintaining upward intentions. Evidence suggests that AT can reduce disability associated with PD, but a mechanism for this effect has not yet been established. Objective We investigated whether AT-based instructions reduce axial rigidity and increase upright postural alignment, and whether these instructions have different effects on postural alignment, axial rigidity, postural sway, and mobility than effort-based instructions regarding posture. Method Twenty subjects with PD practiced two sets of instructions and then attempted to implement both approaches (as well as a relaxed control condition) during quiet standing and step initiation. The ‘Lighten Up’ instructions relied on AT principles of reducing excess tension while encouraging length. The ‘Pull Up’ instructions relied on popular concepts of effortful posture correction. We measured kinematics, resistance to axial rotation, and ground reaction forces. Results Both sets of experimental instructions led to increases in upright postural alignment relative to the control condition. Only the Lighten Up instructions led to reduced postural sway, reduced axial postural tone, greater modifiability of tone, and a smoother center of pressure trajectory during step initiation, possibly indicating greater movement efficiency. Conclusion Mindful movement approaches such as AT may benefit balance and mobility in subjects with PD by acutely facilitating increased upright postural alignment while decreasing rigidity. PMID:25665828

  7. Supported-sorbent injection. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, S. Jr.

    1997-07-01

    A new retrofitable, wastefree acid-rain control concept was pilot-tested at Ohio Edison`s high-sulfur coal-fired R.E. Burger generating station at the 2-MWe level. During the project, moistened {open_quotes}supported{close_quotes} sorbents, made from a combination of lime and vermiculite or perlite, were injected into a humidified 6,500-acfm flue-gas slipstream. After the sorbents reacted with the sulfur dioxide in the flue gas, they were removed from ductwork with a cyclone and baghouse. The $1.0 million project was co-funded by Sorbent Technologies Corporation, the Ohio Edison Company, and the Ohio Coal Development Office. The project included a preliminary bench-scale testing phase, construction of the pilot plant, parametric studies, numerous series of recycle tests, and a long-term run. The project proceeded as anticipated and achieved its expected results. This duct injection technology successfully demonstrated SO{sub 2}-removal rates of 80 to 90% using reasonable stoichiometric injection ratios (2:1 Ca:S) and approach temperatures (20-25F). Under similar conditions, dry injection of hydrated lime alone typically only achieves 40 to 50% SO{sub 2} removal. During the testing, no difficulties were encountered with deposits in the ductwork or with particulate control, which have been problems in tests of other duct-injection schemes.

  8. Syringe-injectable electronics.

    Science.gov (United States)

    Liu, Jia; Fu, Tian-Ming; Cheng, Zengguang; Hong, Guosong; Zhou, Tao; Jin, Lihua; Duvvuri, Madhavi; Jiang, Zhe; Kruskal, Peter; Xie, Chong; Suo, Zhigang; Fang, Ying; Lieber, Charles M

    2015-07-01

    Seamless and minimally invasive three-dimensional interpenetration of electronics within artificial or natural structures could allow for continuous monitoring and manipulation of their properties. Flexible electronics provide a means for conforming electronics to non-planar surfaces, yet targeted delivery of flexible electronics to internal regions remains difficult. Here, we overcome this challenge by demonstrating the syringe injection (and subsequent unfolding) of sub-micrometre-thick, centimetre-scale macroporous mesh electronics through needles with a diameter as small as 100 μm. Our results show that electronic components can be injected into man-made and biological cavities, as well as dense gels and tissue, with >90% device yield. We demonstrate several applications of syringe-injectable electronics as a general approach for interpenetrating flexible electronics with three-dimensional structures, including (1) monitoring internal mechanical strains in polymer cavities, (2) tight integration and low chronic immunoreactivity with several distinct regions of the brain, and (3) in vivo multiplexed neural recording. Moreover, syringe injection enables the delivery of flexible electronics through a rigid shell, the delivery of large-volume flexible electronics that can fill internal cavities, and co-injection of electronics with other materials into host structures, opening up unique applications for flexible electronics.

  9. Syringe injectable electronics

    Science.gov (United States)

    Hong, Guosong; Zhou, Tao; Jin, Lihua; Duvvuri, Madhavi; Jiang, Zhe; Kruskal, Peter; Xie, Chong; Suo, Zhigang; Fang, Ying; Lieber, Charles M.

    2015-01-01

    Seamless and minimally-invasive three-dimensional (3D) interpenetration of electronics within artificial or natural structures could allow for continuous monitoring and manipulation of their properties. Flexible electronics provide a means for conforming electronics to non-planar surfaces, yet targeted delivery of flexible electronics to internal regions remains difficult. Here, we overcome this challenge by demonstrating syringe injection and subsequent unfolding of submicrometer-thick, centimeter-scale macroporous mesh electronics through needles with a diameter as small as 100 micrometers. Our results show that electronic components can be injected into man-made and biological cavities, as well as dense gels and tissue, with > 90% device yield. We demonstrate several applications of syringe injectable electronics as a general approach for interpenetrating flexible electronics with 3D structures, including (i) monitoring of internal mechanical strains in polymer cavities, (ii) tight integration and low chronic immunoreactivity with several distinct regions of the brain, and (iii) in vivo multiplexed neural recording. Moreover, syringe injection enables delivery of flexible electronics through a rigid shell, delivery of large volume flexible electronics that can fill internal cavities and co-injection of electronics with other materials into host structures, opening up unique applications for flexible electronics. PMID:26053995

  10. Tidal Triggering and Statistical Patterns of Microseismicity at Axial Volcano on the Juan de Fuca Ridge

    Science.gov (United States)

    Bohnenstiehl, D. R.; Dziak, R. P.; Caplan-Auerbach, J.; Haxel, J. H.; Mann, M. E.; Pennington, C.; Weis, J.; Womack, N.; Levy, S.

    2015-12-01

    Tidal stress changes are known to modulate the timing of microearthquakes within many mid-ocean ridge volcanic systems. At Axial Volcano, located on the Juan de Fuca Ridge, earthquakes occur preferentially when volumetric extension peaks near times of low ocean tide. Autonomous ocean-bottom hydrophone (OBH, 2007-2011) and cabled ocean bottom seismometer (OBS, Nov. 2014-) data are used to quantify the strength of tidal triggering in time periods before the April 2011 and April 2015 eruptions at Axial Volcano. The mean percent excess at times of low ocean-tide is ~14% (16% std) in the four years prior to the 2011 eruption and ~18% (17% std) in the five months prior to the 2015 eruption. The sensitivity of earthquakes to tidal stress does not evolve systematically prior to either eruption; however, this pattern is disturbed by much larger stress changes associated with the onset of dike intrusion. Following dike injection and eruption, seismicity rates drop sharply. As seismicity rates continue to rise in the months following the 2015 eruption, real-time data available from the cabled OBS network will be used quantify temporal patterns in microearthquake activity as dike induced stresses are relaxed and the magma chamber inflates.

  11. Experimental investigation on circumferential and axial temperature gradient over fuel channel under LOCA

    Science.gov (United States)

    Yadav, Ashwini Kumar; kumar, Ravi; Gupta, Akhilesh; Chatterjee, Barun; Mukhopadhyay, Deb; Lele, H. G.

    2014-06-01

    In a nuclear reactor temperature rises drastically in fuel channels under loss of coolant accident due to failure of primary heat transportation system. Present investigation has been carried out to capture circumferential and axial temperature gradients during fully and partially voiding conditions in a fuel channel using 19 pin fuel element simulator. A series of experiments were carried out by supplying power to outer, middle and center rods of 19 pin fuel simulator in ratio of 1.4:1.1:1. The temperature at upper periphery of pressure tube (PT) was slightly higher than at bottom due to increase in local equivalent thermal conductivity from top to bottom of PT. To simulate fully voided conditions PT was pressurized at 2.0 MPa pressure with 17.5 kW power injection. Ballooning initiated from center and then propagates towards the ends and hence axial temperature difference has been observed along the length of PT. For asymmetric heating, upper eight rods of fuel simulator were activated and temperature difference up-to 250 °C has been observed from top to bottom periphery of PT. Such situation creates steep circumferential temperature gradient over PT and could lead to breaching of PT under high pressure.

  12. Investigation of axial power gradients near a control rod tip

    Energy Technology Data Exchange (ETDEWEB)

    Loberg, John, E-mail: John.Loberg@fysast.uu.se [Uppsala University, Department of Physics and Astronomy, Division of Applied Nuclear Physics, Box 525, SE-75120 Uppsala (Sweden); Osterlund, Michael, E-mail: Michael.Osterlund@fysast.uu.se [Uppsala University, Department of Physics and Astronomy, Division of Applied Nuclear Physics, Box 525, SE-75120 Uppsala (Sweden); Bejmer, Klaes-Hakan, E-mail: Klaes-Hakan.Bejmer@vattenfall.com [Vattenfall Nuclear Fuel AB, Jaemtlandsgatan 99, 162 60 Vaellingby, Stockholm (Sweden); Blomgren, Jan, E-mail: Jan.Blomgren@vattenfall.com [Vattenfall Nuclear Fuel AB, Jaemtlandsgatan 99, 162 60 Vaellingby, Stockholm (Sweden); Kierkegaard, Jesper, E-mail: Jesper.Kierkegaar@vattenfall.com [Vattenfall Nuclear Fuel AB, Jaemtlandsgatan 99, 162 60 Vaellingby, Stockholm (Sweden)

    2011-07-15

    Highlights: > Pin power gradients near BWR control rod tips have been investigated. > A control rod tip is modeled in MCNP and compared to simplified 2D/3D geometry. > Small nodes increases pin power gradients; standard nodes underestimates gradients. > The MCNP results are validated against axial gamma scan of a controlled fuel pin. - Abstract: Control rod withdrawal in BWRs induces large power steps in the adjacent fuel assemblies. This paper investigates how well a 2D/3D method, e.g., CASMO5/SIMULATE5 computes axial pin power gradients adjacent to an asymmetrical control-rod tip in a BWR. The ability to predict pin power gradients accurately is important for safety considerations whereas large powers steps induced by control rod withdrawal can cause Pellet Cladding Interaction. The computation of axial pin power gradients axially around a control rod tip is a challenging task for any nodal code. On top of that, asymmetrical control rod handles are present in some BWR designs. The lattice code CASMO requires diagonal symmetry of all control rod parts. This introduces an error in computed pin power gradients that has been evaluated by Monte Carlo calculations. The results show that CASMO5/SIMULATE5, despite the asymmetrical control rod handle, is able to predict the axial pin power gradient within 1%/cm for axial nodal sizes of 15-3.68 cm. However, a nodal size of 3.68 cm still causes underestimations of pin power gradients compared with 1 cm nodes. Furthermore, if conventional node sizes are used, {approx}15 cm, pin power gradients can be underestimated by over 50% compared with 1 cm nodes. The detailed axial pin power profiles from MCNP are corroborated by measured gamma scan data on fuel rods irradiated adjacent to control rods.

  13. Axial length as a risk factor to branch retinal vein occlusion

    NARCIS (Netherlands)

    Timmerman, EA; deLavalette, VWR; vandenBrom, HJB

    1997-01-01

    Purpose: To determine whether axial length is a factor in branch retinal vein occlusion. Methods: Axial length measurements in a group of 24 patients with a unilateral branch retinal Vein occlusion were compared with the axial length measurements in a control group. axial length measurements were ta

  14. Intracytoplasmic Sperm Injection (ICSI)

    Science.gov (United States)

    ... sperm must attach to the outside of the egg. Once attached, the sperm pushes through the outer layer to the inside ... in vitro fertilization (IVF) to help fertilize the egg. During ICSI, a single sperm is injected directly into the cytoplasm the egg. ...

  15. Water injection dredging

    NARCIS (Netherlands)

    Verhagen, H.J.

    2000-01-01

    Some twenty years ago WIS-dredging has been developed in the Netherlands. By injecting water into the mud layer, the water content of the mud becomes higher, it becomes fluid mud and will start to flow. The advantages of this system are that there is no need of transporting the mud in a hopper, and

  16. Giving an insulin injection

    Science.gov (United States)

    ... an alcohol wipe on your injection site. The insulin needs to go into the fat layer under the skin. Pinch the skin and put the needle in at a 45º angle. If your tissues are thick enough, you may be able to ...

  17. Issues about axial diffusion during segmental hair analysis.

    Science.gov (United States)

    Kintz, Pascal

    2013-06-01

    The detection of a single drug exposure in hair (doping offence, drug-facilitated crime) is based on the presence of the compound of interest in the segment corresponding to the period of the alleged event. However, in some cases, the drug is detected in consecutive segments. As a consequence, interpretation of the results is a challenge that deserves particular attention. Literature evaluation and data obtained from the 20-year experience in drug testing in hair of the author are used as the basis to establish a theory to validate the concept of single exposure in authentic forensic cases where the drug is detected in 2 or 3 segments. The gained experience recommends to wait for 4-5 weeks after the alleged event and then to collect strands of hair. Assuming normal hair growth rate (1 cm/mo), it is advisable to cut the strand into 3 segments of 2 cm to document eventual exposure. Administration of a single dose would be confirmed by the presence of the drug in the proximal 2-cm segment (root), whereas not detected in the 2 other segments. However, in the daily experience of the author, it was noticed that sometimes (about 1 case from 10 examinations), the drug can be detected in 2 or 3 consecutive segments. Such a disposition was even observed in volunteer experiments in the literature. As it was also described for cocaine in early 1996, there is considerable variability in the area over which incorporated drug can be distributed in the hair shaft and in the rate of axial distribution of drug along the hair shaft. This can explain why a small amount of drug, as compared with the concentration in the proximal segment, can be measured in the second segment, as a result of an irregular movement. Another explanation for broadening the band of positive hair from a single dose is that drugs and metabolites are incorporated into hair during formation of the hair shaft via diffusion from sweat and other secretions. The presence of confounding interferences in the hair

  18. Method to measure tone of axial and proximal muscle.

    Science.gov (United States)

    Gurfinkel, Victor S; Cacciatore, Timothy W; Cordo, Paul J; Horak, Fay B

    2011-12-14

    The control of tonic muscular activity remains poorly understood. While abnormal tone is commonly assessed clinically by measuring the passive resistance of relaxed limbs, no systems are available to study tonic muscle control in a natural, active state of antigravity support. We have developed a device (Twister) to study tonic regulation of axial and proximal muscles during active postural maintenance (i.e. postural tone). Twister rotates axial body regions relative to each other about the vertical axis during stance, so as to twist the neck, trunk or hip regions. This twisting imposes length changes on axial muscles without changing the body's relationship to gravity. Because Twister does not provide postural support, tone must be regulated to counteract gravitational torques. We quantify this tonic regulation by the restive torque to twisting, which reflects the state of all muscles undergoing length changes, as well as by electromyography of relevant muscles. Because tone is characterized by long-lasting low-level muscle activity, tonic control is studied with slow movements that produce "tonic" changes in muscle length, without evoking fast "phasic" responses. Twister can be reconfigured to study various aspects of muscle tone, such as co-contraction, tonic modulation to postural changes, tonic interactions across body segments, as well as perceptual thresholds to slow axial rotation. Twister can also be used to provide a quantitative measurement of the effects of disease on axial and proximal postural tone and assess the efficacy of intervention.

  19. Design and Simulation of Axial Flow Maglev Blood Pump

    Directory of Open Access Journals (Sweden)

    Huachun Wu

    2011-03-01

    Full Text Available The axial flow maglev blood pump (AFMBP has become a global research focus and emphasis for artificial ventricular assist device, which has no mechanical contact, mechanical friction, compact structure and light weight, can effectively solve thrombus and hemolysis. Magnetic suspension and impeller is two of the important parts in the axial flow maglev blood pump, and their structure largely determines the blood pump performance. The research adopts electromagnetic and fluid finite element analysis, and puts forward a method to design the magnetic suspension and impeller of axial flow blood pump, which tacks into account the small volume of axial blood pump. The magnetic bearing’s characteristics are evaluated by electromagnetic finite element analysis. The Blades have been designed by calculating aerofoil bone line, and make simulation analysis for different thicken ways of blade by Fluent software, and make a conclusion that the blade thickened with certain rules has better characteristics in the same conditions. The results will provide some guidance for design of axial flow maglev blood pump, and establish theoretical basis for application of the implantable artificial heart pump.

  20. Light weakly coupled axial forces: models, constraints, and projections

    Science.gov (United States)

    Kahn, Yonatan; Krnjaic, Gordan; Mishra-Sharma, Siddharth; Tait, Tim M. P.

    2017-05-01

    We investigate the landscape of constraints on MeV-GeV scale, hidden U(1) forces with nonzero axial-vector couplings to Standard Model fermions. While the purely vector-coupled dark photon, which may arise from kinetic mixing, is a well-motivated scenario, several MeV-scale anomalies motivate a theory with axial couplings which can be UV-completed consistent with Standard Model gauge invariance. Moreover, existing constraints on dark photons depend on products of various combinations of axial and vector couplings, making it difficult to isolate the effects of axial couplings for particular flavors of SM fermions. We present a representative renormalizable, UV-complete model of a dark photon with adjustable axial and vector couplings, discuss its general features, and show how some UV constraints may be relaxed in a model with nonrenormalizable Yukawa couplings at the expense of fine-tuning. We survey the existing parameter space and the projected reach of planned experiments, briefly commenting on the relevance of the allowed parameter space to low-energy anomalies in π0 and 8Be∗ decay.

  1. An Axial Vector Photon in a Mirror World

    CERN Document Server

    Sharafiddinov, Rasulkhozha S

    2015-01-01

    The unity of symmetry laws emphasizes, in the case of a mirror CP-even Dirac Lagrangian, the ideas of the left- and right-handed axial-vector photons referring to long- and short-lived bosons of true neutrality, respectively. Such a difference in lifetimes expresses the unidenticality of masses, energies and momenta of axial-vector photons of the different components. They define the unified field theory equation of C-odd particles with an integral spin. Together with a new equation of a theory of truly neutral particles with the half-integral spin, the latter reflects the availability in their nature of the second type of the local axial-vector gauge transformation responsible for origination in the Lagrangian of C-oddity of an interaction Newton component giving an axial-vector mass to all the interacting particles and fields. The mirror axial-vector mass, energy and momentum operators constitute a CP-invariant equation of quantum mechanics, confirming that each of them can individually influence on matter ...

  2. Light Weakly Coupled Axial Forces: Models, Constraints, and Projections

    CERN Document Server

    Kahn, Yonatan; Mishra-Sharma, Siddharth; Tait, Tim M P

    2016-01-01

    We investigate the landscape of constraints on MeV-GeV scale, hidden U(1) forces with nonzero axial-vector couplings to Standard Model fermions. While the purely vector-coupled dark photon, which may arise from kinetic mixing, is a well-motivated scenario, several MeV-scale anomalies motivate a theory with axial couplings which can be UV-completed consistent with Standard Model gauge invariance. Moreover, existing constraints on dark photons depend on products of various combinations of axial and vector couplings, making it difficult to isolate the effects of axial couplings for particular flavors of SM fermions. We present a representative renormalizable, UV-complete model of a dark photon with adjustable axial and vector couplings, discuss its general features, and show how some UV constraints may be relaxed in a model with nonrenormalizable Yukawa couplings at the expense of fine-tuning. We survey the existing parameter space and the projected reach of planned experiments, briefly commenting on the relevan...

  3. Light Weakly Coupled Axial Forces: Models, Constraints, and Projections

    Energy Technology Data Exchange (ETDEWEB)

    Kahn, Yonatan [Princeton U.; Krnjaic, Gordan [Fermilab; Mishra-Sharma, Siddharth [Princeton U.; Tait, Tim P. [UC, Irvine

    2016-09-28

    We investigate the landscape of constraints on MeV-GeV scale, hidden U(1) forces with nonzero axial-vector couplings to Standard Model fermions. While the purely vector-coupled dark photon, which may arise from kinetic mixing, is a well-motivated scenario, several MeV-scale anomalies motivate a theory with axial couplings which can be UV-completed consistent with Standard Model gauge invariance. Moreover, existing constraints on dark photons depend on products of various combinations of axial and vector couplings, making it difficult to isolate the effects of axial couplings for particular flavors of SM fermions. We present a representative renormalizable, UV-complete model of a dark photon with adjustable axial and vector couplings, discuss its general features, and show how some UV constraints may be relaxed in a model with nonrenormalizable Yukawa couplings at the expense of fine-tuning. We survey the existing parameter space and the projected reach of planned experiments, briefly commenting on the relevance of the allowed parameter space to low-energy anomalies in pi^0 and 8-Be* decay.

  4. Axial clamp for nuclear reactor head penetration conoseal joints

    Energy Technology Data Exchange (ETDEWEB)

    Hackley, T.A.

    1987-03-31

    A method is described for forming a sealed coupling between two bodies, each body presenting an annular abutment surface. The respective bodies are arranged so that their respective annular abutment surfaces are axially adjacent one another, defining a space therebetween, wherein a deformable gasket is disposed within the space. The method comprises: providing one of the bodies with an annular projection; providing the other body with threads for receiving an annular locknut which can be tightened to bear against the annular projection of the one body; applying an external axial forced to the bodies for compressing the abutment surfaces together against the gasket to form a seal between the bodies; immobilizing the bodies relative to one another while the external force is being applied to the bodies by hand-tightening an annular locknut via the threads of the other body until the locknut abuts the annular projection of the one body, substantially preventing relative axial movement between the bodies when the external axial force is withdrawn; and withdrawing the external axial force applied to the bodies, leaving the two bodies coupled together via the seal.

  5. An Axial-Vector Photon in a Mirror World

    Science.gov (United States)

    Sharafiddinov, Rasulkhozha S.

    2016-03-01

    The unity of symmetry laws emphasizes, in the case of a mirror CP-even Dirac Lagrangian, the ideas of the left- and right-handed axial-vector photons referring to long- and short-lived bosons of true neutrality, respectively. Such a difference in lifetimes expresses the unidenticality of masses, energies and momenta of axial-vector photons of the different components. They define the unified field theory equation of C-odd particles with an integral spin. Together with a new equation of a theory of truly neutral particles with the half-integral spin, the latter reflects the availability in their nature of the second type of the local axial-vector gauge transformation responsible for origination in the Lagrangian of C-oddity of an interaction Newton component giving an axial-vector mass to all the interacting particles and fields. The mirror axial-vector mass, energy and momentum operators constitute a CP-invariant equation of quantum mechanics, confirming that each of them can individually influence on matter field. Thereby, findings suggest at the level of the mass-charge structure of gauge invariance a new equation for the C-noninvariant Lagrangian.

  6. Construction and tests of demonstrator modules for a 3-D axial PET system for brain or small animal imaging

    CERN Document Server

    Chesi, E; Clinthorne, N; Pauss, P; Meddi, F; Beltrame, P; Kagan, H; Braem, A; Casella, C; Djambazov, G; Smith, S; Johnson, I; Lustermann, W; Weilhammer, P; Nessi-Tedaldi, F; Dissertori, G; Renker, D; Schneider, T; Schinzel, D; Honscheid, K; De Leo, R; Bolle, E; Fanti, V; Rafecas, M; Cochran, E; Rudge, A; Stapnes, S; Huh, S; Seguinot, J; Solevi, P; Joram, C; Oliver, J F

    2011-01-01

    The design and construction of a PET camera module with high sensitivity, full 3-D spatial reconstruction and very good energy resolution is presented. The basic principle consists of an axial arrangement of long scintillation crystals around the Field Of View (FOV), providing a measurement of the transverse coordinates of the interacting 511 keV gamma ray. On top of each layer of crystals, an array of Wave-Length Shifter (WLS) strips, which collect the light leaving the crystals sideways, is positioned orthogonal to the crystal direction. The signals in the WLS strips allow a precise measurement of the z (axial) co-ordinate of the 511 keV gamma-ray gamma impact. The construction of two modules used for demonstration of the concept is described. First preliminary results on spatial and energy resolution from one full module will be shown. (C) 2010 Elsevier B.V. All rights reserved.

  7. Computation of the lateral and axial point spread functions in confocal imaging systems using binary amplitude mask

    Indian Academy of Sciences (India)

    A M Hamed

    2006-06-01

    In this paper, a novel aperture based on Tolardo concept composed of a central clear disc surrounded by a series of black and white (B/W) concentric annuli of equal transmittance is presented. Different apodized apertures of different number of B/W annuli are suggested in order to improve further the three-dimensional resolving power of confocal imaging systems. Both the axial and lateral point spread functions (PSF) and the corresponding irradiances are computed in both cases of conventional and confocal scanning microscopes for the above-mentioned amplitude filters. These results of axial and lateral irradiances are graphically represented by constructing a computer program using MATLAB. The obtained results are compared with that obtained in case of circular, annular, and Martinez-Corral apodized aperture.

  8. Mathematical concepts

    CERN Document Server

    Jost, Jürgen

    2015-01-01

    The main intention of this book is to describe and develop the conceptual, structural and abstract thinking of mathematics. Specific mathematical structures are used to illustrate the conceptual approach; providing a deeper insight into mutual relationships and abstract common features. These ideas are carefully motivated, explained and illustrated by examples so that many of the more technical proofs can be omitted. The book can therefore be used: ·         simply as an overview of the panorama of mathematical structures and the relations between them, to be supplemented by more detailed texts whenever you want to acquire a working knowledge of some structure ·         by itself as a first introduction to abstract mathematics ·         together with existing textbooks, to put their results into a more general perspective ·         to gain a new and hopefully deeper perspective after having studied such textbooks Mathematical Concepts has a broader scope and is less detaile...

  9. Axial and radial water transport and internal water storage in tropical forest canopy trees.

    Science.gov (United States)

    James, Shelley A; Meinzer, Frederick C; Goldstein, Guillermo; Woodruff, David; Jones, Timothy; Restom, Teresa; Mejia, Monica; Clearwater, Michael; Campanello, Paula

    2003-01-01

    Heat and stable isotope tracers were used to study axial and radial water transport in relation to sapwood anatomical characteristics and internal water storage in four canopy tree species of a seasonally dry tropical forest in Panama. Anatomical characteristics of the wood and radial profiles of sap flow were measured at the base, upper trunk, and crown of a single individual of Anacardium excelsum, Ficus insipida, Schefflera morototoni, and Cordia alliodora during two consecutive dry seasons. Vessel lumen diameter and vessel density did not exhibit a consistent trend axially from the base of the stem to the base of the crown. However, lumen diameter decreased sharply from the base of the crown to the terminal branches. The ratio of vessel lumen area to sapwood cross-sectional area was consistently higher at the base of the crown than at the base of the trunk in A. excelsum, F. insipida and C. alliodora, but no axial trend was apparent in S. morototoni. Radial profiles of the preceding wood anatomical characteristics varied according to species and the height at which the wood samples were obtained. Radial profiles of sap flux density measured with thermal dissipation sensors of variable length near the base of the crown were highly correlated with radial profiles of specific hydraulic conductivity (k(s)) calculated from xylem anatomical characteristics. The relationship between sap flux density and k(s) was species-independent. Deuterium oxide (D(2)O) injected into the base of the trunk of the four study trees was detected in the water transpired from the upper crown after only 1 day in the 26-m-tall C. alliodora tree, 2 days in the 28-m-tall F. insipida tree, 3 days in the 38-m-tall A. excelsum tree, and 5 days in the 22-m-tall S. morototoni tree. Radial transport of injected D(2)O was detected in A. excelsum, F. insipida and S. morototoni, but not C. alliodora. The rate of axial D(2)O transport, a surrogate for maximum sap velocity, was positively correlated

  10. Experimental signatures of the mixed axial-gravitational anomaly in the Weyl semimetal NbP

    Science.gov (United States)

    Gooth, Johannes; Niemann, Anna C.; Meng, Tobias; Grushin, Adolfo G.; Landsteiner, Karl; Gotsmann, Bernd; Menges, Fabian; Schmidt, Marcus; Shekhar, Chandra; Süß, Vicky; Hühne, Ruben; Rellinghaus, Bernd; Felser, Claudia; Yan, Binghai; Nielsch, Kornelius

    2017-07-01

    The conservation laws, such as those of charge, energy and momentum, have a central role in physics. In some special cases, classical conservation laws are broken at the quantum level by quantum fluctuations, in which case the theory is said to have quantum anomalies. One of the most prominent examples is the chiral anomaly, which involves massless chiral fermions. These particles have their spin, or internal angular momentum, aligned either parallel or antiparallel with their linear momentum, labelled as left and right chirality, respectively. In three spatial dimensions, the chiral anomaly is the breakdown (as a result of externally applied parallel electric and magnetic fields) of the classical conservation law that dictates that the number of massless fermions of each chirality are separately conserved. The current that measures the difference between left- and right-handed particles is called the axial current and is not conserved at the quantum level. In addition, an underlying curved space-time provides a distinct contribution to a chiral imbalance, an effect known as the mixed axial-gravitational anomaly, but this anomaly has yet to be confirmed experimentally. However, the presence of a mixed gauge-gravitational anomaly has recently been tied to thermoelectrical transport in a magnetic field, even in flat space-time, suggesting that such types of mixed anomaly could be experimentally probed in condensed matter systems known as Weyl semimetals. Here, using a temperature gradient, we observe experimentally a positive magneto-thermoelectric conductance in the Weyl semimetal niobium phosphide (NbP) for collinear temperature gradients and magnetic fields that vanishes in the ultra-quantum limit, when only a single Landau level is occupied. This observation is consistent with the presence of a mixed axial-gravitational anomaly, providing clear evidence for a theoretical concept that has so far eluded experimental detection.

  11. Initial hydrodynamic study on a new intraaortic axial flow pump: Dynamic aortic valve

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Rotary blood pumps have been researched as implantableventricular assist devices for years. To further reduce the complex of implanted axial pumps, the authors proposed a new concept of intraaortic axial pump, termed previously as "dynamic aortic valve (DAV)". Instead of being driven by an intraaortic micro-electric motor, it was powered by a magnetic field from outside of body. To ensure the perfusion of coronary artery, the axial flow pump is to be implanted in the position of aortic valve. It could serve as either a blood pump or a mechanical valve depending on the power input. This research tested the feasibility of the new concept in model study. A column, made from permanent magnet, is jointed to an impeller in a concentric way to form a "rotor-impeller". Supported by a hanging shaft cantilevered in the center of a rigid cage, the rotor-impeller can be turned by the magnetic field in the surrounding space. In the present prototype, the rotor is 8 mm in diameter and 15 mm in length, the impeller has 3 vanes with an outer diameter of 18 mm. The supporting cage is 22 mm in outer diameter and 20 mm in length. When tested, the DAV prototype is inserted into the tube of a mock circuit. The alternative magnetic field is produced by a rotating magnet placed side by side with the rotor-impeller at a distance of 30 mm. Once the alternative magnetic field is presented in the surrounding space, the DAV starts to turn, leading to a pressure difference and liquid flow in the tube. The flow rate or pressure difference is proportioned to rotary speed. At the maximal output of hydraulic power, the flow rate reached 5 L/min against an afterload of 100 mmHg. The maximal pressure difference generated by DAV at a rotation rate of 12600 r/min was 147 mmHg. The preliminary results demonstrated the feasibility of "DAV", further research on this concept is justifiable.

  12. Dynamic Behavior of Axially Functionally Graded Pipes Conveying Fluid

    Directory of Open Access Journals (Sweden)

    Chen An

    2017-01-01

    Full Text Available Dynamic behavior of axially functionally graded (FG pipes conveying fluid was investigated numerically by using the generalized integral transform technique (GITT. The transverse vibration equation was integral transformed into a coupled system of second-order differential equations in the temporal variable. The Mathematica’s built-in function, NDSolve, was employed to numerically solve the resulting transformed ODE system. Excellent convergence of the proposed eigenfunction expansions was demonstrated for calculating the transverse displacement at various points of axially FG pipes conveying fluid. The proposed approach was verified by comparing the obtained results with the available solutions reported in the literature. Moreover, parametric studies were performed to analyze the effects of Young’s modulus variation, material distribution, and flow velocity on the dynamic behavior of axially FG pipes conveying fluid.

  13. Bistability between equatorial and axial dipoles during magnetic field reversals

    CERN Document Server

    Gissinger, Christophe; Schrinner, Martin; Dormy, Emmanuel

    2012-01-01

    Numerical simulations of the geodynamo in presence of an heterogeneous heating are presented. We study the dynamics and the structure of the magnetic field when the equatorial symmetry of the flow is broken. If the symmetry breaking is sufficiently strong, the m = 0 axial dipolar field is replaced by an hemispherical magnetic field, dominated by an oscillating m = 1 magnetic field. Moreover, for moderate symmetry breaking, a bistability between the axial and the equatorial dipole is observed. In this bistable regime, the axial magnetic field exhibits chaotic switches of its polarity, involving the equatorial dipole during the transition period. This new scenario for magnetic field reversals is discussed within the framework of the Earth's dynamo.

  14. Bistability between equatorial and axial dipoles during magnetic field reversals.

    Science.gov (United States)

    Gissinger, Christophe; Petitdemange, Ludovic; Schrinner, Martin; Dormy, Emmanuel

    2012-06-08

    Numerical simulations of the geodynamo in the presence of heterogeneous heating are presented. We study the dynamics and the structure of the magnetic field when the equatorial symmetry of the flow is broken. If the symmetry breaking is sufficiently strong, the m=0 axial dipolar field is replaced by a hemispherical magnetic field, dominated by an oscillating m=1 magnetic field. Moreover, for moderate symmetry breaking, a bistability between the axial and the equatorial dipole is observed. In this bistable regime, the axial magnetic field exhibits chaotic switches of its polarity, involving the equatorial dipole during the transition period. This new scenario for magnetic field reversals is discussed within the framework of Earth's dynamo.

  15. Numerical analysis of cavitation within slanted axial-flow pump

    Institute of Scientific and Technical Information of China (English)

    张睿; 陈红勋

    2013-01-01

    In this paper, the cavitating flow within a slanted axial-flow pump is numerically researched. The hydraulic and cavitation performance of the slanted axial-flow pump under different operation conditions are estimated. Compared with the experimental hydraulic performance curves, the numerical results show that the filter-based model is better than the standard k-e model to predict the parameters of hydraulic performance. In cavitation simulation, compared with the experimental results, the proposed numerical method has good predicting ability. Under different cavitation conditions, the internal cavitating flow fields within slanted axial-flow pump are investigated. Compared with flow visualization results, the major internal flow features can be effectively grasped. In order to explore the origin of the cavitation performance breakdown, the Boundary Vorticity Flux (BVF) is introduced to diagnose the cavitating flow fields. The analysis results indicate that the cavitation performance drop is relevant to the instability of cavitating flow on the blade suction surface.

  16. Unsteady cooperative flow type in the axial compressor

    Institute of Scientific and Technical Information of China (English)

    ZHENG Xinqian; ZHOU Sheng; HOU Anping; XIONG Jinsong

    2005-01-01

    For increasing the performance of the axial compressor, a method for realizing unsteady cooperative flow type is proposed in this paper as a critical objective in the new generation of the axial compressor design system. Unsteady excitations were utilized to trigger the transformation from the unsteady natural flow pattern into the unsteady cooperative flow pattern, resulting in increment of aerodynamic performances of axial compressor. Numerical simulations show that distinct positive effect can be obtained for the 2D cascade in a wide range of subsonic working conditions. No positive effect can be observed under the 2D supersonic working conditions and unsteady excitations have little influence on the flow field space-time structure. However, positive effect can be obtained under the 3D transsonic working conditions. In addition, engineering applications of unsteady cooperative flow type are discussed.

  17. Investigation of Aluminum-Copper Tube Hydroforming with Axial Feeding

    Science.gov (United States)

    Parto D., M.; Seyedkashi, S. M. H.; Liaghat, Gh.; Naeini, H. Moslemi; Panahizadeh R., V.

    2011-01-01

    Hydroforming of a two-layered Aluminum-Copper tube is investigated numerically and experimentally. Pressure is applied through a nonlinear path along with symmetrical axial feeding. ABAQUS/Explicit commercial code is used for finite element simulation of the process. ASTM C11000 Copper alloy is used as inner layer and ASTM AA1050A Aluminum alloy is used as outer layer. The simulation results show that the part can be successfully formed under internal pressure of 40 MPa with 8 mm axial displacement. Stress distributions on both inner and outer tubes are compared and maximum thinning on their wall is also discussed. Different friction conditions are applied on the process using different coefficients of friction and their effects are investigated on thinning percentage of inner and outer tubes and also on axial feeding. It is observed that finite element results are in good agreement with experimental results.

  18. Ball Screw Actuator Including an Axial Soft Stop

    Science.gov (United States)

    Wingett, Paul T. (Inventor); Forrest, Steven Talbert (Inventor); Abel, Steve (Inventor); Woessner, George (Inventor); Hanlon, Casey (Inventor)

    2016-01-01

    An actuator includes an actuator housing, a ball screw, and an axial soft stop assembly. The ball screw extends through the actuator housing and has a first end and a second end. The ball screw is coupled to receive a drive force and is configured, upon receipt of the drive force, to selectively move in a retract direction and an extend direction. The axial soft stop assembly is disposed within the actuator housing. The axial soft stop assembly is configured to be selectively engaged by the ball screw and, upon being engaged thereby, to translate, with compliance, a predetermined distance in the extend direction, and to prevent further movement of the ball screw upon translating the predetermined distance.

  19. Liquid Axial Mixing in Packed Tower at Elevated Pressure

    Institute of Scientific and Technical Information of China (English)

    唐忠利; 张鹏; 等

    2003-01-01

    Liquid phase axial mixing was measured with the tracer technique in a packed column with inner diameter of 0.15m,in which the structured packing,Mellapak 350Y,was installed.Tap water as the liquid phase flowed down through the column and stagnant gas was at elevated pressure ranging from atmospheric to 2.0MPa.The model parameters of Bo andθwere estimated with the least square method in the time domain.As liquid flow rate was increased,the liquid axial mixing decreased.under our experimental conditions,the effect of pressure on Bo number on single liquid phase was negligible,and eddy diffusion was believed to be the primary cause of axial mixing in liquid phase.

  20. Regional brain axial and radial diffusivity changes during development.

    Science.gov (United States)

    Kumar, Rajesh; Nguyen, Haidang D; Macey, Paul M; Woo, Mary A; Harper, Ronald M

    2012-02-01

    The developing human brain shows rapid myelination and axonal changes during childhood, adolescence, and early adulthood, requiring successive evaluations to determine normative values for potential pathological assessment. Fiber characteristics can be examined by axial and radial diffusivity procedures, which measure water diffusion parallel and perpendicular to axons and show primarily axonal status and myelin changes, respectively. Such measures are lacking from widespread sites for the developing brain. Diffusion tensor imaging data were acquired from 30 healthy subjects (age 17.7 ± 4.6 years, range 8-24 years, body mass index 21.5 ± 4.5 kg/m(2), 18 males) using a 3.0-Tesla MRI scanner. Diffusion tensors were calculated, principal eigenvalues determined, and axial and radial diffusivity maps calculated and normalized to a common space. A set of regions of interest was outlined from widespread brain areas within rostral, thalamic, hypothalamic, cerebellar, and pontine regions, and average diffusivity values were calculated using normalized diffusivity maps and these regions of interest masks. Age-related changes were assessed with Pearson's correlations, and gender differences evaluated with Student's t-tests. Axial and radial diffusivity values declined with age in the majority of brain areas, except for midhippocampus, where axial diffusivity values correlated positively with age. Gender differences emerged within putamen, thalamic, hypothalamic, cerebellar, limbic, temporal, and other cortical sites. Documentation of normal axial and radial diffusivity values will help assess disease-related tissue changes. Axial and radial diffusivities change with age,with fiber structure and organization differing between sexes in several brain areas. The findings may underlie gender-based functional characteristics, and mandate partitioning age- and gender-related changes during developmental brain pathology evaluation.

  1. Fuel injection nozzle and method of manufacturing the same

    Energy Technology Data Exchange (ETDEWEB)

    Monaghan, James Christopher; Johnson, Thomas Edward; Ostebee, Heath Michael

    2017-02-21

    A fuel injection head for use in a fuel injection nozzle comprises a monolithic body portion comprising an upstream face, an opposite downstream face, and a peripheral wall extending therebetween. A plurality of pre-mix tubes are integrally formed with and extend axially through the body portion. Each of the pre-mix tubes comprises an inlet adjacent the upstream face, an outlet adjacent the downstream face, and a channel extending between the inlet and the outlet. Each pre-mix tube also includes at least one fuel injector that at least partially extends outward from an exterior surface of the pre-mix tube, wherein the fuel injector is integrally formed with the pre-mix tube and is configured to facilitate fuel flow between the body portion and the channel.

  2. Instability of Meridional Axial System in f(R) Gravity

    CERN Document Server

    Sharif, M

    2015-01-01

    We analyze dynamical instability of non-static reflection axial stellar structure by taking into account generalized Euler's equation in metric $f(R)$ gravity. Such an equation is obtained by contracting Bianchi identities of usual anisotropic and effective stress-energy tensors, which after using radial perturbation technique gives modified collapse equation. In the realm of $R+\\epsilon R^n$ gravity model, we investigate instability constraints at Newtonian and post-Newtonian approximations. We find that instability of meridional axial self-gravitating system depends upon static profile of structure coefficients while $f(R)$ extra curvature terms induce stability to the evolving celestial body.

  3. Vector and Axial Currents in Wilson Chiral Perturbation Theory

    CERN Document Server

    Aoki, Sinya; Sharpe, Stephen R

    2009-01-01

    We reconsider the construction of the vector and axial-vector currents in Wilson Chiral Perturbation Theory (WChPT), the low-energy effective theory for lattice QCD with Wilson fermions. We discuss in detail the finite renormalization of the currents that has to be taken into account in order to properly match the currents. We explicitly show that imposing the chiral Ward identities on the currents does, in general, affect the axial-vector current at O(a). As an application of our results we compute the pion decay constant to one loop in the two flavor theory. Our result differs from previously published ones.

  4. Buckling localization in a cylindrical panel under axial compression

    DEFF Research Database (Denmark)

    Tvergaard, Viggo; Needleman, A.

    2000-01-01

    Localization of an initially periodic buckling pattern is investigated for an axially compressed elastic-plastic cylindrical panel of the type occurring between axial stiffeners on cylindrical shells. The phenomenon of buckling localization and its analogy with plastic flow localization in tensile...... test specimens is discussed in general. For the cylindrical panel, it is shown that buckling localization develops shortly after a maximum load has been attained, and this occurs for a purely elastic panel as well as for elastic-plastic panels. In a case where localization occurs after a load maximum...

  5. Self-collimated axial jets from thin accretion disks

    CERN Document Server

    Tirabassi, Giulio; Carlevaro, Nakia; Benini, Riccardo

    2012-01-01

    We show how an appropriate stationary crystalline structure of the magnetic field can induce a partial fragmentation of the accretion disk, generating an axial jet composed of hot rising plasma twisted in a funnel-like structure by the rotation of the system. The most important feature of the obtained jet is its high degree of collimation, naturally arising from the condition for its existence. The presence of non-zero dissipative effects allows the plasma ejection throughout the axial jet and the predicted values of the accretion rate are in agreement with observations.

  6. Spectral analysis in thin tubes with axial heterogeneities

    KAUST Repository

    Ferreira, Rita

    2015-01-01

    In this paper, we present the 3D-1D asymptotic analysis of the Dirichlet spectral problem associated with an elliptic operator with axial periodic heterogeneities. We extend to the 3D-1D case previous 3D-2D results (see [10]) and we analyze the special case where the scale of thickness is much smaller than the scale of the heterogeneities and the planar coefficient has a unique global minimum in the periodic cell. These results are of great relevance in the comprehension of the wave propagation in nanowires showing axial heterogeneities (see [17]).

  7. An effective theory for QCD with an axial chemical potential

    CERN Document Server

    Andrianov, Alexander A; Espriu, Domenec; Planells, Xumeu

    2013-01-01

    We consider the low energy realization of QCD in terms of meson fields when an axial chemical potential is present; a situation that may be relevant in heavy ion collisions. We shall demonstrate that the presence of an axial charge constitutes an explicit source of parity breaking. The eigenstates of strong interactions do not have a definite parity and interactions that would otherwise be forbidden compete with the familiar ones. In this work, we first focus on scalars and pseudoscalars that are described by a generalized linear sigma model; and next, we give some hints on how the Vector Meson Dominance model describes the vector sector.

  8. Fermion decoupling and the axial anomaly on the lattice

    CERN Document Server

    Banerjee, H; De, Asit K.

    1999-01-01

    By an explicit calculation of the continuum limit of the triangle graph amplitude in lattice QED we show that in the axial Ward identity the ABJ anomaly exactly cancels the pseudoscalar density term in the limit of infinite fermion mass $m$. The result, a reflection of decoupling of the heavy fermion, provides a convenient framework for computing the flavor-singlet or U(1) axial anomaly in non-Abelian gauge theories on lattice. Our calculations on the lattice are performed using Wilson fermions but the results are general.

  9. The axial topographic high at intermediate and fast spreading ridges

    Science.gov (United States)

    Carbotte, Suzanne M.; MacDonald, Ken C.

    1994-12-01

    An axial topographic high is commonly observed at both fast spreading ridges and some segments of intermediate spreading ridges. At fast rates the axial high is primarily created by the buoyancy of hot rock and magma beneath the rise. As newly formed crust is transported off axis, little vestige of an axial high is observed on the ridge flanks. In contrast, at intermediate rates, a significant component of the positive topography may be a volcanic construction, preserved on the ridge flanks as abyssal hills, which are slit axial volcanoes. We suggest this difference in the nature of the axial high reflects a lithosphere strong enough to support construction of a volcanic crestal ridge at intermediate spreading rates, but only rarely at fast rates. Relict overlap ridges, found within the discordant zones left by overlapping spreading centers, is one class of ridge-flank topography which appears to have a significant volcanic constructional component even at fast spreading ridges. Unlike topography away from these discontinuities, the relief and shape of overlapping spreading centers is preserved as relict ridge tips are rafted onto the ridge flanks. Reduced magma supply at these discontinuities may give rise to an axial lithosphere strong enough to support volcanic construction of overlap ridges. Low axial lithospheric strength may also account for the lack of normal faults within the innermost 1-2 km of fast, and some intermediate, spreading ridges. With a thin/weak brittle layer at the ridge crest, tensile failure will predominate and few normal faults will form. Depths to the axial magma chamber reflector observed in multi-channel seismic data limit the thickness of the brittel layer on axis to less than 1-2 km for much of the East Pacific Rise (EPR). This depth is comparable to depths over which tensile failure within the oceanic crust will predominate, estimated from the Griffith criteria for fracture initiation (approx. 0.5-1.5 km). As the brittle layer

  10. Recent Results on High-Pressure Axial Blowers

    Science.gov (United States)

    Eckert, B.

    1947-01-01

    Considerable progress has, in recent times, been attained in the development of the high-pressure axial blower by well-planned research. The efforts are directed toward improving the efficiencies, which are already high for the axial blower, and in particular the delivery pressure heads. For high pressures multistage arrangements are used. Of fundamental importance is the careful design of all structural parts of the blower that are subject to the effects of the flow. In the present report, several recent results and experiences are reported, which are based on results of German engine research.

  11. The seismic design of axial blower using Ansys

    Energy Technology Data Exchange (ETDEWEB)

    Im, Hyung Bin; Kim, Kang Sung; Heo, Jin Wook; Chung, Jin Tai [Hanyang Univ., Seoul (Korea, Republic of)

    2001-07-01

    The seismic design for an axial blower is the procedure in which the Required Response Spectrum(RRS) is computed by using the Floor Response Spectrum(FRS). The seismic design is very important to reduce severe damages from an earthquake; therefore, the seismic design has been a great concern in engineering society. In this study, after finite element modeling is established by using Ansys, the modal data are obtained such as the natural frequencies, the participation factor, and so on. With these data, the RRS is acquired by a numerical approach. The seismic safety of the axial blower is evaluated.

  12. Injection-controlled laser resonator

    Science.gov (United States)

    Chang, J.J.

    1995-07-18

    A new injection-controlled laser resonator incorporates self-filtering and self-imaging characteristics with an efficient injection scheme. A low-divergence laser signal is injected into the resonator, which enables the injection signal to be converted to the desired resonator modes before the main laser pulse starts. This injection technique and resonator design enable the laser cavity to improve the quality of the injection signal through self-filtering before the main laser pulse starts. The self-imaging property of the present resonator reduces the cavity induced diffraction effects and, in turn, improves the laser beam quality. 5 figs.

  13. Fracture analysis of axially cracked pressure tube of pressurized heavy water reactor

    Energy Technology Data Exchange (ETDEWEB)

    Krishnan, S.; Bhasin, V.; Mahajan, S.C. [Bhabha Atomic Research Centre, Bombay (India)] [and others

    1997-04-01

    Three Dimensional (313) finite element elastic plastic fracture analysis was done for through wall axially cracked thin pressure tubes of 220 MWe Indian Pressurized Heavy Water Reactor. The analysis was done for Zr-2 and Zr-2.5Nb pressure tubes operating at 300{degrees}C and subjected to 9.5 Mpa internal pressure. Critical crack length was determined based on tearing instability concept. The analysis included the effect of crack face pressure due to the leaking fluid from tube. This effect was found to be significant for pressure tubes. The available formulae for calculating J (for axially cracked tubes) do not take into account the effect of crack face pressure. 3D finite element analysis also gives insight into variation of J across the thickness of pressure tube. It was observed that J is highest at the mid-surface of tube. The results have been presented in the form of across the thickness average J value and a peak factor on J. Peak factor on J is ratio of J at mid surface to average J value. Crack opening area for different cracked lengths was calculated from finite element results. The fracture assessment of pressure tubes was also done using Central Electricity Generating Board R-6 method. Ductile tearing was considered.

  14. Nanosized sustained-release drug depots fabricated using modified tri-axial electrospinning.

    Science.gov (United States)

    Yang, Guang-Zhi; Li, Jiao-Jiao; Yu, Deng-Guang; He, Mei-Feng; Yang, Jun-He; Williams, Gareth R

    2017-01-27

    Nanoscale drug depots, comprising a drug reservoir surrounded by a carrier membrane, are much sought after in contemporary pharmaceutical research. Using cellulose acetate (CA) as a filament-forming polymeric matrix and ferulic acid (FA) as a model drug, nanoscale drug depots in the form of core-shell fibers were designed and fabricated using a modified tri-axial electrospinning process. This employed a solvent mixture as the outer working fluid, as a result of which a robust and continuous preparation process could be achieved. The fiber-based depots had a linear morphology, smooth surfaces, and an average diameter of 0.62±0.07μm. Electron microscopy data showed them to have clear core-shell structures, with the FA encapsulated inside a CA shell. X-ray diffraction and IR spectroscopy results verified that FA was present in the crystalline physical form. In vitro dissolution tests revealed that the fibers were able to provide close to zero-order release over 36h, with no initial burst release and minimal tailing-off. The release properties of the depot systems were much improved over monolithic CA/FA fibers, which exhibited a significant burst release and also considerable tailing-off at the end of the release experiment. Here we thus demonstrate the concept of using modified tri-axial electrospinning to design and develop new types of heterogeneous nanoscale biomaterials.

  15. Effects of inlet circumferential fluctuation on the sweep aerodynamic performance of axial fans/compressors

    Science.gov (United States)

    Gui, Xingmin; Zhu, Fang; Wan, Ke; Jin, Donghai

    2013-10-01

    Swept blades have been widely used in the transonic fan/compressor of aircraft engines with the aids of 3D CFD simulation since the design concept of controlling the shock structure was firstly proposed and successfully tested by Dr. Wennerstrom in the 1980s. However, some disadvantage phenomenon has also been induced by excessively 3D blade geometries on the structure stress insufficiency, vibration and reliability. Much confusion in the procedure of design practice leading us to recognize a new view on the flow mechanism of sweep aerodynamical induction: the new radial equilibrium established by the influence of inlet circumferential fluctuation (CF) changes the inlet flows of blading and induces the performance modification of axial fans/compressors blade. The view is verified by simplified models through numerical simulation and circumferentially averaged analysis in the present paper. The results show that the CF source items which originate from design parameters, such as the spanwise distributions of the loading and blading geometries, contribute to the changing of averaged incidence spanwise distribution, and further more affect the performance of axial fans/compressors with swept blades.

  16. SPS injection kicker magnet

    CERN Multimedia

    1975-01-01

    One of the first-generation SPS injection kicker magnets, view of the complete tank. First proton beam from the PS was injected into the SPS in 1976, at a beam momentum of 10 GeV/c. These kickers served until the end of 1979 and were replaced at the beginning of 1980 by stronger ones, in preparation for the SPS as a proton-antiproton collider. For this, transfer momentum from the PS to the SPS was raised to 26 GeV/c, so as to avoid acceleration of the dense p and pbar bunches through SPS transition energy. Bearded Roland Tröhler is at the left, Giacomo Busetta smiles at the right. See also 7502073X, 7502074X and Annual Report 1975, 162.

  17. LDA measurements in a Mach 2 flow over a rearward facing step with staged transverse injection

    Science.gov (United States)

    Wang, J.-A.; Dancey, C. L.

    1992-01-01

    Measurements of the mean velocity field and selected turbulence statistics have been obtained via 2D LDA in a Mach 2 flow over a rearward facing step with downstream transverse injection. Axial mean velocity profiles, profiles of the axial and normal RMS levels, and the correlation coefficient between the axial and normal fluctuating components are presented for locations upstream of the step. These data, through comparison with other reported measurements in zero pressure gradient compressible boundary layers indicate that the boundary layers upstream of the step are consistent with 'quasi-equilibrium' turbulent boundary layers with the adiabatic wall boundary condition. Mean velocity field measurements on the symmetry plane of the tunnel are compared to laser induced iodine fluorescence measurements reported in the literature and obtained in the same facility. This comparison demonstrates the quality of the present LDA data set and shows that particle lag is not significant in the LDA measurements despite the complex nature of the downstream flow.

  18. LDA measurements in a Mach 2 flow over a rearward facing step with staged transverse injection

    Science.gov (United States)

    Wang, J.-A.; Dancey, C. L.

    1992-01-01

    Measurements of the mean velocity field and selected turbulence statistics have been obtained via 2D LDA in a Mach 2 flow over a rearward facing step with downstream transverse injection. Axial mean velocity profiles, profiles of the axial and normal RMS levels, and the correlation coefficient between the axial and normal fluctuating components are presented for locations upstream of the step. These data, through comparison with other reported measurements in zero pressure gradient compressible boundary layers indicate that the boundary layers upstream of the step are consistent with 'quasi-equilibrium' turbulent boundary layers with the adiabatic wall boundary condition. Mean velocity field measurements on the symmetry plane of the tunnel are compared to laser induced iodine fluorescence measurements reported in the literature and obtained in the same facility. This comparison demonstrates the quality of the present LDA data set and shows that particle lag is not significant in the LDA measurements despite the complex nature of the downstream flow.

  19. PS injection area

    CERN Multimedia

    1974-01-01

    Looking against the direction of protons in the main ring (left): the beam coming from the linac 1 either goes to the booster (on the right) or is deflected towards the PS to be directly injected into section 26 (facing the camera). Also shown the start of the TT2 line, ejected from straight section 16 to go towards the ISR passing over the beam line from the linac. (see Photo Archive 7409009)

  20. Injection-induced earthquakes.

    Science.gov (United States)

    Ellsworth, William L

    2013-07-12

    Earthquakes in unusual locations have become an important topic of discussion in both North America and Europe, owing to the concern that industrial activity could cause damaging earthquakes. It has long been understood that earthquakes can be induced by impoundment of reservoirs, surface and underground mining, withdrawal of fluids and gas from the subsurface, and injection of fluids into underground formations. Injection-induced earthquakes have, in particular, become a focus of discussion as the application of hydraulic fracturing to tight shale formations is enabling the production of oil and gas from previously unproductive formations. Earthquakes can be induced as part of the process to stimulate the production from tight shale formations, or by disposal of wastewater associated with stimulation and production. Here, I review recent seismic activity that may be associated with industrial activity, with a focus on the disposal of wastewater by injection in deep wells; assess the scientific understanding of induced earthquakes; and discuss the key scientific challenges to be met for assessing this hazard.

  1. Injection-induced earthquakes

    Science.gov (United States)

    Ellsworth, William L.

    2013-01-01

    Earthquakes in unusual locations have become an important topic of discussion in both North America and Europe, owing to the concern that industrial activity could cause damaging earthquakes. It has long been understood that earthquakes can be induced by impoundment of reservoirs, surface and underground mining, withdrawal of fluids and gas from the subsurface, and injection of fluids into underground formations. Injection-induced earthquakes have, in particular, become a focus of discussion as the application of hydraulic fracturing to tight shale formations is enabling the production of oil and gas from previously unproductive formations. Earthquakes can be induced as part of the process to stimulate the production from tight shale formations, or by disposal of wastewater associated with stimulation and production. Here, I review recent seismic activity that may be associated with industrial activity, with a focus on the disposal of wastewater by injection in deep wells; assess the scientific understanding of induced earthquakes; and discuss the key scientific challenges to be met for assessing this hazard.

  2. Evidence for bacteriophage T7 tail extension during DNA injection

    Directory of Open Access Journals (Sweden)

    Hakala Kevin W

    2008-06-01

    Full Text Available Abstract Background Electron micrographs of bacteriophage T7 reveal a tail shorter than needed to reach host cytoplasm during infection-initiating injection of a T7 DNA molecule through the tail and cell envelope. However, recent data indicate that internal T7 proteins are injected before the DNA molecule is injected. Thus, bacteriophage/host adsorption potentially causes internal proteins to become external and lengthen the tail for DNA injection. But, the proposed adsorption-induced tail lengthening has never been visualized. Findings In the present study, electron microscopy of particles in T7 lysates reveals a needle-like capsid extension that attaches partially emptied bacteriophage T7 capsids to non-capsid vesicles and sometimes enters an attached vesicle. This extension is 40–55 nm long, 1.7–2.4× longer than the T7 tail and likely to be the proposed lengthened tail. The extension is 8–11 nm in diameter, thinner than most of the tail, with an axial hole 3–4 nm in diameter. Though the bound vesicles are not identified by microscopy, these vesicles resemble the major vesicles in T7 lysates, found to be E. coli outer membrane vesicles by non-denaturing agarose gel electrophoresis, followed by mass spectrometry. Conclusion The observed lengthened tail is long enough to reach host cytoplasm during DNA injection. Its channel is wide enough to be a conduit for DNA injection and narrow enough to clamp DNA during a previously observed stalling/re-starting of injection. However, its outer diameter is too large to explain formation by passing of an intact assembly through any known capsid hole unless the hole is widened.

  3. Dynamic response of the occipito-atlanto-axial (C0-C1-C2) complex in right axial rotation.

    Science.gov (United States)

    Chang, H; Gilbertson, L G; Goel, V K; Winterbottom, J M; Clark, C R; Patwardhan, A

    1992-05-01

    The torque-angular deformation in right axial rotation until failure of the ligamentous occipito-atlanto-axial complex subjected to variable loading rate (dynamic) axial torque was characterized using a biaxial MTS system. A special fixture and gear box that permitted right axial rotation of the specimen until failure without imposing any additional constraints were used to obtain the data. The specimens were divided into three groups and tested until failure at three different dynamic loading rates: 50, 100, and 400 degrees/s. A previous study by the authors provided data for quasi-static (4 degrees/s) loading conditions. The torque versus rotation curves can be divided into two straight regions and two transition zones. The plots clearly indicated that at loading rates higher than 4 degrees/s, the specimens became stiffer in the region of steadily increasing resistance prior to failure. The increase in stiffness was maximum at 100 degrees/s. The stiffness decreased somewhat at 400 degrees/s in comparison with 100 degrees/s, but this decrease was not significant. The resulting torque-right axial rotation curves were also examined to estimate the magnitude of maximum resistance (torque) and the corresponding angular rotation value. The average maximum resistance torque increased from 13.6 Nm at 4 degrees/s to 27.8 Nm at 100 degrees/s. The corresponding right angular rotation data (65-78 degrees), however, did not show any significant variation with loading rate. Posttest dissection of the specimens indicated that the type of injury observed was related to the rate of axial loading imposed on a specimen during testing.(ABSTRACT TRUNCATED AT 250 WORDS)

  4. Aerodynamic parametric studies and sensitivity analysis for rotor blades in axial flight

    Science.gov (United States)

    Chiu, Y. D.; Peters, David A.

    1991-01-01

    The analytical capability is offered for aerodynamic parametric studies and sensitivity analyses of rotary wings in axial flight by using a 3D undistorted wake model in curved lifting line theory. The governing equations are solved by both the Multhopp Interpolation technique and the Vortex Lattice method. The singularity from the bound vortices is eliminated through the Hadamard's finite part concept. Good numerical agreement between both analytical methods and finite differences methods are found. Parametric studies were made to assess the effects of several shape variables on aerodynamic loads. It is found, e.g., that a rotor blade with out-of-plane and inplane curvature can theoretically increase lift in the inboard and outboard regions respectively without introducing an additional induced drag.

  5. Aerodynamic parameter studies and sensitivity analysis for rotor blades in axial flight

    Science.gov (United States)

    Chiu, Y. Danny; Peters, David A.

    1991-01-01

    The analytical capability is offered for aerodynamic parametric studies and sensitivity analyses of rotary wings in axial flight by using a 3-D undistorted wake model in curved lifting line theory. The governing equations are solved by both the Multhopp Interpolation technique and the Vortex Lattice method. The singularity from the bound vortices is eliminated through the Hadamard's finite part concept. Good numerical agreement between both analytical methods and finite differences methods are found. Parametric studies were made to assess the effects of several shape variables on aerodynamic loads. It is found, e.g., that a rotor blade with out-of-plane and inplane curvature can theoretically increase lift in the inboard and outboard regions respectively without introducing an additional induced drag.

  6. Design, fabrication and test of lightweight shell structure. [axial compression loads and torsion stress

    Science.gov (United States)

    Lager, J. R.

    1975-01-01

    A cylindrical shell structure 3.66 m (144 in.) high by 4.57 m (180 in.) diameter was designed using a wide variety of materials and structural concepts to withstand design ultimate combined loading 1225.8 N/cm (700 lb/in.) axial compression and 245.2 N/cm (140 lb/in.) torsion. The overall cylinder geometry and design loading are representative of that expected on a high performance space tug vehicle. The relatively low design load level results in designs that use thin gage metals and fibrous-composite laminates. Fabrication and structural tests of small panels and components representative of many of the candidate designs served to demonstrate proposed fabrication techniques and to verify design and analysis methods. Three of the designs evaluated, honeycomb sandwich with aluminum faceskins, honeycomb sandwich with graphite/epoxy faceskins, and aluminum truss with fiber-glass meteoroid protection layers, were selected for further evaluation.

  7. Dissipative collapse of axially symmetric, general relativistic, sources: A general framework and some applications

    CERN Document Server

    Herrera, L; Ibañez, J; Ospino, J

    2014-01-01

    We carry out a general study on the collapse of axially (and reflection) symmetric sources in the context of general relativity. All basic equations and concepts required to perform such a general study are deployed. These equations are written down for a general anisotropic dissipative fluid. The proposed approach allows for analytical studies as well as for numerical applications. A causal transport equation derived from the Israel-Stewart theory is applied, to discuss some thermodynamic aspects of the problem. A set of scalar functions (the structure scalars) derived from the orthogonal splitting of the Riemann tensor are calculated and their role in the dynamics of the source is clearly exhibited. The characterization of the gravitational radiation emitted by the source is discussed.

  8. Axial Vibration Analysis of the Mud Recovery Line on Deepwater Riserless Mud Recovery Drilling System

    Institute of Scientific and Technical Information of China (English)

    王国栋; 陈国明; 许亮斌; 殷志明

    2014-01-01

    The series connection of multistage pumping module is the common concept of deepwater riserless mud recovery drilling system. In this system, the influence of the mass of pumping module on the vibration of mud recovery line cannot be ignored, and the lumped mass method has been utilized to discretize the mud recovery line. Based on the analysis of different boundary conditions, the paper establishes the axial forced vibration model of the mud recovery line considering the seawater damping, and the vibration model analysis provides the universal solution to the vibration model. An example of the two-stage pumping system has been used to analyze the dynamic response of mud recovery line under different excited frequencies. This paper has the important directive significance for the application of riserless mud recovery drilling technology in deepwater surface drilling.

  9. Transversal symmetry breaking and axial spreading modification for Gaussian optical beams

    CERN Document Server

    Araujo, Manoel; Lima, Marina

    2016-01-01

    For a long time it was believed there was no reason to include the geometrical phase in studying the propagation of gaussian optical beams through dielectric blocks. This can be justified by the fact that the first order term in the Taylor expansion of this phase is responsible for the lateral shift of the optical beam which is also predicted by ray optics. From this point of view, the geometrical phase can be seen as a purely auxiliary concept. In this paper, we show how the second order term in the Taylor expansion accounts for the symmetry breaking of the transversal spatial distribution and acts as an axial spreading modifier. These new effects clearly shows the importance of the geometrical phase in describing the correct behavior of light. To test our theoretical predictions, we briefly discuss a possible experimental implementation.

  10. Steroid injections - tendon, bursa, joint

    Science.gov (United States)

    ... medlineplus.gov/ency/article/007678.htm Steroid injections - tendon, bursa, joint To use the sharing features on ... painful. It can be injected into a joint, tendon, or bursa. Description Your health care provider inserts ...

  11. Amphotericin B Lipid Complex Injection

    Science.gov (United States)

    Amphotericin B lipid complex injection is used to treat serious, possibly life-threatening fungal infections in people who did not respond ... to tolerate conventional amphotericin B therapy. Amphotericin B lipid complex injection is in a class of medications ...

  12. Injection treatments for patellar tendinopathy

    NARCIS (Netherlands)

    van Ark, Mathijs; Zwerver, Johannes; van den Akker-Scheek, Inge

    2011-01-01

    Objective Injection treatments are increasingly used as treatment for patellar tendinopathy. The aim of this systematic review is to describe the different injection treatments, their rationales and the effectiveness of treating patellar tendinopathy. Methods A computerised search of the Medline,

  13. Lumbar intervertebral disc degeneration associated with axial and radiating low back pain in ageing SPARC-null mice.

    Science.gov (United States)

    Millecamps, Magali; Tajerian, Maral; Naso, Lina; Sage, E Helene; Stone, Laura S

    2012-06-01

    Chronic low back pain (LBP) is a complex, multifactorial disorder with unclear underlying mechanisms. In humans and rodents, decreased expression of secreted protein acidic rich in cysteine (SPARC) is associated with intervertebral disc (IVD) degeneration and signs of LBP. The current study investigates the hypothesis that IVD degeneration is a risk factor for chronic LBP. SPARC-null and age-matched control mice ranging from 6 to 78 weeks of age were evaluated in this study. X-ray and histologic analysis revealed reduced IVD height, increased wedging, and signs of degeneration (bulging and herniation). Cutaneous sensitivity to cold, heat, and mechanical stimuli were used as measures of referred (low back and tail) and radiating pain (hind paw). Region specificity was assessed by measuring icilin- and capsaicin-evoked behaviour after subcutaneous injection into the hind paw or upper lip. Axial discomfort was measured by the tail suspension and grip force assays. Motor impairment was determined by the accelerating rotarod. Physical function was evaluated by voluntary activity after axial strain or during ambulation with forced lateral flexion. SPARC-null mice developed (1) region-specific, age-dependent hypersensitivity to cold, icilin, and capsaicin (hind paw only), (2) axial discomfort, (3) motor impairment, and (4) reduced physical function. Morphine (6 mg/kg, i.p.) reduced cutaneous sensitivity and alleviated axial discomfort in SPARC-null mice. Ageing SPARC-null mice mirror many aspects of the complex and challenging nature of LBP in humans and incorporate both anatomic and functional components of the disease. The current study supports the hypothesis that IVD degeneration is a risk factor for chronic LBP.

  14. Characterization of the Axial Jet Separator with a CO2/Helium Mixture: Toward GC-AMS Hyphenation.

    Science.gov (United States)

    Salazar, G; Agrios, K; Eichler, R; Szidat, S

    2016-02-02

    Development of interfaces for sample introduction from high pressures is important for real-time online hyphenation of chromatographic and other separation devices with mass spectrometry (MS) or accelerator mass spectrometry (AMS). Momentum separators can reduce unwanted low-density gases and introduce the analyte into the vacuum. In this work, the axial jet separator, a new momentum interface, is characterized by theory and empirical optimization. The mathematical model describes the different axial penetration of the components of a jet-gas mixture and explains the empirical results for injections of CO2 in helium into MS and AMS instruments. We show that the performance of the new interface is sensitive to the nozzle size, showing good qualitative agreement with the mathematical model. Smaller nozzle sizes are more preferable due to their higher inflow capacity. The CO2 transmission efficiency of the interface into a MS instrument is ∼ 14% (CO2/helium separation factor of 2.7). The interface receives and delivers flows of ∼ 17.5 mL/min and ∼ 0.9 mL/min, respectively. For the interfaced AMS instrument, the ionization and overall efficiencies are 0.7-3% and 0.1-0.4%, respectively, for CO2 amounts of 4-0.6 μg C, which is only slightly lower compared to conventional systems using intermediate trapping. The ionization efficiency depends on to the carbon mass flow in the injected pulse and is suppressed at high CO2 flows. Relative to a conventional jet separator, the transmission efficiency of the axial jet separator is lower, but its performance is less sensitive to misalignments.

  15. On aspects of vibration of axially moving continua

    NARCIS (Netherlands)

    Hageraats-Ponomareva, S.

    2009-01-01

    In axially moving structures like conveyor belt systems, magnetic tapes, and so on, vibrations occur due to the presence of different kinds of imperfections in the systems. For these structures internal resonances can lead to severe vibrations. Resonance free conveyor belt systems can be constructed

  16. Numerical Study of Axial Turbulent Flow Over Long Cylinders

    Science.gov (United States)

    1992-04-01

    DATAV [NZ/2, MTH, 3, MR] and as DATAP[NZ/2, MTH, MR], respectively. The first index indicates the axial (streamwise) wave number I = 1, ... , NZ/2...MTH + 12, 12 !5 MTH/2, -[(THGR -1) *MTH + 12- MTH/2], I2> MTH/2. The third index in DATAV indicates the velocity component according to/3 = 3 (1 -4 V

  17. Static Tension Tests on Axially Loaded Pile Segments in Sand

    DEFF Research Database (Denmark)

    Thomassen, Kristina; Andersen, Lars Vabbersgaard; Ibsen, Lars Bo

    This paper provides laboratory test results of static axially loaded piles in sand. With a newly developed test setup, the pile-soil interface friction was investigated by using an open-ended steel pile segment with a diameter of 0.5 m. Use of a pile length of 1 m enabled the pile-soil interface...

  18. Spiral thickenings in the axial Parenchyma of Chrysobalanaceae

    NARCIS (Netherlands)

    Welle, ter B.J.H.

    1976-01-01

    Spiral thickenings in the axial parenchyma, seldom recorded in the secondary xylem of the dicotyledons so far, are described for a number of genera and/or species of Chrysobalanaceae. In 66 out of 99 samples investigated, representing most genera of the Chrysobalanaceae, spiral thickenings proved to

  19. Dynamic Response of Axially Loaded Euler-Bernoulli Beams

    DEFF Research Database (Denmark)

    Bayat, M.; Barari, Amin; Shahidi, M.

    2011-01-01

    The current research deals with application of a new analytical technique called Energy Balance Method (EBM) for a nonlinear problem. Energy Balance Method is used to obtain the analytical solution for nonlinear vibration behavior of Euler-Bernoulli beams subjected to axial loads. Analytical...

  20. On the Applications of Axial Representation of Trigonometric Functions

    Science.gov (United States)

    Siadat, M. Vali

    2006-01-01

    In terms of modern pedagogy, having visual interpretation of trigonometric functions is useful and quite helpful. This paper presents, pictorially, an easy approach to prove all single angle trigonometric identities on the axes. It also discusses the application of axial representation in calculus--finding the derivative of trigonometric functions.

  1. An axially symmetric solution of metric-affine gravity

    CERN Document Server

    Vlachynsky, E J; Obukhov, Yu N; Hehl, F W

    1996-01-01

    We present an exact stationary {\\it axially symmetric} vacuum solution of metric-affine gravity (MAG) which generalises the recently reported spherically symmetric solution. Besides the metric, it carries nonmetricity and torsion as post-Riemannian geometrical structures. The parameters of the solution are interpreted as mass and angular momentum and as dilation, shear and spin charges.

  2. On the Applications of Axial Representation of Trigonometric Functions

    Science.gov (United States)

    Siadat, M. Vali

    2006-01-01

    In terms of modern pedagogy, having visual interpretation of trigonometric functions is useful and quite helpful. This paper presents, pictorially, an easy approach to prove all single angle trigonometric identities on the axes. It also discusses the application of axial representation in calculus--finding the derivative of trigonometric functions.

  3. Treatment with tumor necrosis factor inhibitors in axial spondyloarthritis

    DEFF Research Database (Denmark)

    Ciurea, A.; Weber, U.; Stekhoven, D.

    2015-01-01

    Objective. To evaluate the initiation of and response to tumor necrosis factor (TNF) inhibitors for axial spondyloarthritis (axSpA) in private rheumatology practices versus academic centers. The Journal of Rheumatology, Methods.We compared newly initiated TNF inhibition for axSpA in 363 patients...

  4. On aspects of vibration of axially moving continua

    NARCIS (Netherlands)

    Hageraats-Ponomareva, S.

    2009-01-01

    In axially moving structures like conveyor belt systems, magnetic tapes, and so on, vibrations occur due to the presence of different kinds of imperfections in the systems. For these structures internal resonances can lead to severe vibrations. Resonance free conveyor belt systems can be constructed

  5. On the generation techniques of axially symmetric stationary metrics

    Indian Academy of Sciences (India)

    S Chaudhuri

    2002-03-01

    In the present paper, a relationship between the method of Gutsunaev–Manko and the soliton technique (for two-soliton solutions) of Belinskii–Zakharov, for generating solutions of axially symmetric stationary space-times in general relativity is discussed.

  6. Limb-length discrepancy measured with computerized axial tomographic equipment

    Energy Technology Data Exchange (ETDEWEB)

    Huurman, W.W.; Jacobsen, F.S.; Anderson, J.C.; Chu, W.K.

    1987-06-01

    A simple, rapid, and accurate method for measuring limb-length discrepancies with computerized axial tomographic equipment is described. With this method less irradiation is delivered and some of the errors of computation are eliminated, compared with conventional methods. The costs of the technique are comparable with those of scanograms. The method is particularly applicable in the patient who has contracture of a joint.

  7. Observers in spacetimes with spherical and axial symmetries

    OpenAIRE

    Gusin, Pawel; Kusnierz, Bartosz; Radosz, Andrzej

    2015-01-01

    We introduce in the explicit form the tetrads of arbitrary observers in spacetimes with spherical and axial symmetries. The observers confined to the equatorial plane are parametrized by the pair of functions. We apply this description in the analysis of the null-geodesics in the observers' frames. The observers with the constant acceleration are distinguished.

  8. FINITE ELEMENT ANALYSIS OF AXIAL FEED BAR ROLLING

    Institute of Scientific and Technical Information of China (English)

    C.G. Xu; G.H. Liu; G.S. Ren; Z. Shen; C.P. Ma; W. W. Ren

    2007-01-01

    A flexible technique of hot working of bars by axial feed rolling was introduced. The processdeformation, strain field, stress field, and temperature field of the parts are analyzed by finite elementmethod (FEM)-simulation software DEFORM-3D. The material flow rule and tool load have beeninvestigated.

  9. Axially Symmetric Cosmological Mesonic Stiff Fluid Models in Lyra's Geometry

    CERN Document Server

    Gad, Ragab M

    2009-01-01

    In this paper, we obtained a new class of axially symmetric cosmological mesonic stiff fluid models in the context of Lyra's geometry. Expressions for the energy, pressure and the massless scalar field are derived by considering the time dependent displacement field. We found that the mesonic scalar field depends on only $t$ coordinate. Some physical properties of the obtained models are discussed.

  10. Axially symmetric solutions in f(R)-gravity

    CERN Document Server

    Capozziello, Salvatore; Stabile, Arturo

    2009-01-01

    Axially symmetric solutions for f(R)-gravity can be derived starting from exact spherically symmetric solutions. The method takes advantage of a complex coordinate transformation previously developed by Newman and Janis in General Relativity. An example is worked out to show the general validity of the approach.

  11. Axially symmetric solutions in f(R)-gravity

    Energy Technology Data Exchange (ETDEWEB)

    Capozziello, Salvatore; De Laurentis, Mariafelicia [Dipartimento di Scienze Fisiche, Universita di Napoli ' Federico II' (Italy); Stabile, Arturo, E-mail: capozziello@na.infn.i [Dipartimento di Ingegneria, Universita del Sannio, Benevento, C.so Garibaldi 107, I-80125 Benevento (Italy)

    2010-08-21

    Axially symmetric solutions for f(R)-gravity can be derived starting from exact spherically symmetric solutions achieved by Noether symmetries. The method takes advantage of a complex coordinate transformation previously developed by Newman and Janis in general relativity. An example is worked out to show the general validity of the approach. The physical properties of the solution are also considered.

  12. Hydrostatic self-aligning axial/torsional mechanism

    Science.gov (United States)

    O'Connor, Daniel G.; Gerth, Howard L.

    1990-01-01

    The present invention is directed to a self-aligning axial/torsional loading mechanism for testing the strength of brittle materials which are sensitive to bending moments. Disposed inside said self-aligning loading mechanism is a frictionless hydrostatic ball joint with a flexure ring to accommodate torsional loads through said ball joint.

  13. Multi-axial mechanical stimulation of tissue engineered cartilage: Review

    Directory of Open Access Journals (Sweden)

    S D Waldman

    2007-04-01

    Full Text Available The development of tissue engineered cartilage is a promising new approach for the repair of damaged or diseased tissue. Since it has proven difficult to generate cartilaginous tissue with properties similar to that of native articular cartilage, several studies have used mechanical stimuli as a means to improve the quantity and quality of the developed tissue. In this study, we have investigated the effect of multi-axial loading applied during in vitro tissue formation to better reflect the physiological forces that chondrocytes are subjected to in vivo. Dynamic combined compression-shear stimulation (5% compression and 5% shear strain amplitudes increased both collagen and proteoglycan synthesis (76 ± 8% and 73 ± 5%, respectively over the static (unstimulated controls. When this multi-axial loading condition was applied to the chondrocyte cultures over a four week period, there were significant improvements in both extracellular matrix (ECM accumulation and the mechanical properties of the in vitro-formed tissue (3-fold increase in compressive modulus and 1.75-fold increase in shear modulus. Stimulated tissues were also significantly thinner than the static controls (19% reduction suggesting that there was a degree of ECM consolidation as a result of long-term multi-axial loading. This study demonstrated that stimulation by multi-axial forces can improve the quality of the in vitro-formed tissue, but additional studies are required to further optimize the conditions to favour improved biochemical and mechanical properties of the developed tissue.

  14. Axially and spherically symmetric solitons in warm plasma

    CERN Document Server

    Dvornikov, Maxim

    2010-01-01

    We study the existence of stable axially and spherically symmetric plasma structures on the basis of the new nonlinear Schrodinger equation (NLSE) accounting for nonlocal electron nonlinearities. The numerical solutions of NLSE having the form of spatial solitions are obtained and their stability is analyzed. We discuss the possible application of the obtained results to the theoretical description of natural plasmoids in the atmosphere.

  15. Chondrocyte activity is increased in psoriatic arthritis and axial spondyloarthritis

    DEFF Research Database (Denmark)

    Gudmann, Natasja Stæhr; Munk, Heidi Lausten; Christensen, Anne Friesgaard

    2016-01-01

    BACKGROUND: Psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA) are chronic inflammatory rheumatic diseases with complex origins. Both are characterized by altered extracellular matrix remodeling in joints and entheses that results in destructive and osteochondral proliferative lesions...

  16. Etanercept for the treatment of non-radiographic axial spondyloarthritis.

    Science.gov (United States)

    Rios Rodriguez, Valeria; Poddubnyy, Denis

    2016-01-01

    Presently, tumor necrosis factor α antagonist therapy is the only effective alternative treatment to nonsteroidal anti-inflammatory drugs for the entire spectrum of axial spondyloarthritis, including non-radiographic and radiographic (=ankylosing spondylitis) forms. Recently, etanercept has been approved by the European Medicines Agency for the treatment of non-radiographic axial spondyloarthritis, increasing the number of available treatment options for this indication. The latest data on etanercept concerning clinical efficacy and safety in short-term and long-term treatment of patients with non-radiographic axial spondyloarthritis who do not respond to the first-line therapy with non-steroidal anti-inflammatory drugs suggests good efficacy and safety profiles similar to that observed previously in ankylosing spondylitis. This article reviews recent data on the efficacy and safety of etanercept and is focused on the treatment of non-radiographic axial spondyloarthritis. This article will also discuss the role of etanercept in the context of current and developing treatment options.

  17. A cylindrical drift chamber with azimuthal and axial position readout

    Energy Technology Data Exchange (ETDEWEB)

    Bar-Yam, Z.; Cummings, J.P.; Dowd, J.P.; Eugenio, P.; Hayek, M.; Kern, W.; King, E.; Shenhav, N.; Chung, S.U.; Hackenburg, R.W.; Olchanski, C.; Weygand, D.P.; Willutzki, H.J.; Brabson, B.B.; Crittenden, R.R.; Dzierba, A.R.; Gunter, J.; Lindenbusch, R.; Rust, D.R.; Scott, E.; Smith, P.T.; Sulanke, T.; Teige, S.; Denisov, S.; Dushkin, A.; Kochetkov, V.; Lipaev, V.; Popov, A.; Shein, I.; Soldatov, A.; Anoshina, E.V.; Bodyagin, V.A.; Demianov, A.I.; Gribushin, A.M.; Kodolova, O.L.; Korotkikh, V.L.; Kostin, M.A.; Ostrovidov, A.I.; Sarycheva, L.I.; Sinev, N.B.; Vardanyan, I.N.; Yershov, A.A.; Adams, T.; Bishop, J.M.; Cason, N.M.; Sanjari, A.H.; LoSecco, J.M.; Manak, J.J.; Shephard, W.D.; Stienike, D.L.; Taegar, S.A.; Thompson, D.R.; Brown, D.S.; Pedlar, T.; Seth, K.K.; Wise, J.; Zhao, D.; Adams, G.S.; Napolitano, J.; Nozar, M.; Smith, J.A.; Witkowski, M. [Massachusetts Univ., North Dartmouth, MA (United States)]|[Brookhaven National Laboratory, Upton, L.I., NY 11973 (United States)]|[Indiana University, Bloomington, IN 47405 (United States)]|[Institute for High Energy Physics, Protvino (Russian Federation)]|[Institute of Nuclear Physics, Moscow State University, Moscow (Russian Federation)]|[University of Notre Dame, Notre Dame, IN 46556 (United States)]|[Northwestern University, Evanston, IL 60208 (United States)]|[Rensselaer Polytechnic Institute, Troy, NY 12180 (United States)

    1997-02-21

    A cylindrical multiwire drift chamber with axial charge-division has been constructed and used in experiment E852 at Brookhaven National Laboratory. It serves as a trigger element and as a tracking device for recoil protons in {pi}{sup -}p interactions. We describe the chamber`s design considerations, details of its construction, electronics, and performance characteristics. (orig.).

  18. 3-D Simulation of Vertical-Axial Tidal Current Turbine

    Directory of Open Access Journals (Sweden)

    Zhiyang Zhang

    2016-12-01

    Full Text Available Vertical-axial tidal current turbine is the key for the energy converter, which has the advantages of simple structure, adaptability to flow and uncomplex convection device. It has become the hot point for research and application recently. At present, the study on the hydrodynamic performance of vertical-axial tidal current turbine is almost on 2-D numerical simulation, without the consideration of 3-D effect. CFD (Computational Fluid Dynamics method and blade optimal control technique are used to improve accuracy in the prediction of tidal current turbine hydrodynamic performance. Numerical simulation of vertical-axial tidal current turbine is validated. Fixed and variable deflection angle turbine are comparatively studied to analysis the influence of 3-D effect and the character of fluid field and pressure field. The method, put the plate on the end of blade, of reduce the energy loss caused by 3-D effect is proposed. The 3-D CFD numerical model of vertical-axial tidal current turbine hydrodynamic performance in this study may provide theoretical, methodical and technical reference for the optimal design of turbine.

  19. Optimal design of multi-conditions for axial flow pump

    Science.gov (United States)

    Shi, L. J.; Tang, F. P.; Liu, C.; Xie, R. S.; Zhang, W. P.

    2016-11-01

    Passage components of the pump device will have a negative flow state when axial pump run off the design condition. Combined with model tests of axial flow pump, this paper use numerical simulation and numerical optimization techniques, and change geometric design parameters of the impeller to optimal design of multi conditions for Axial Flow Pump, in order to improve the efficiency of non-design conditions, broad the high efficient district and reduce operating cost. The results show that, efficiency curve of optimized significantly wider than the initial one without optimization. The efficiency of low flow working point increased by about 2.6%, the designed working point increased by about 0.5%, and the high flow working point increased the most, about 7.4%. The change range of head is small, so all working point can meet the operational requirements. That will greatly reduce operating costs and shorten the period of optimal design. This paper adopted the CFD simulation as the subject analysis, combined with experiment study, instead of artificial way of optimization design with experience, which proves the reliability and efficiency of the optimization design of multi-operation conditions of axial-flow pump device.

  20. Further comment on pion electroproduction and the axial form factor

    CERN Document Server

    Bernard, V; Meißner, Ulf G; Mei{\\ss}ner, Ulf-G.

    2001-01-01

    We show that a recent claim (H.Haberzettl, Phys. Rev. Lett. 85 (2000) 3576) that one cannot extract the nucleon weak axial form factor G_A (t) from charged pion threshold electroproduction is incorrect. Thus previous calculations remain valid and threshold charged pion electroproduction experiments can indeed be used to determine G_A (t), and they should certainly be pursued.

  1. The cause of axial rotation of the scoliotic spine

    NARCIS (Netherlands)

    Lemmers, L.G.; Sanders, M.M.; Cool, J.C.; Grootenboer, H.J.

    1991-01-01

    To explain the cause of axial rotation in a scoliotic vertebral column, the influence of the gravitation force on a spine with a C-scoliosis has been investigated by means of a mechanical model. In this model the gravitation force takes hold of the three-dimensionally curved vertebral column eccentr

  2. Dynamic Behaviors of Axially Moving Viscoelastic Plate with Varying Thicknessn

    Institute of Scientific and Technical Information of China (English)

    ZHOU Yinfeng; WANG Zhongmin

    2009-01-01

    Structural components of varying thickness draw increasing attention these days due to economy and light-weight considerations. In view of the absence of research in vibration analysis of viscoelastic plate with varying thickness, this study devotes to investigate the dynamic behaviors of axially moving viscoelastic plate with varying thickness. Based on the thin plate theory and the two-dimensional viscoelastic differential constitutive relation, the differential equation of motion of the axially moving viscoelastic rectangular plate is derived, the plate constituted by Kelvin-Voigt model has linearly varying thickness in the y-direction. The dimensionless complex frequencies of axially moving viscoelastic plate with four edges simply supported are calculated by the differential quadrature method, curves of real parts and imaginary parts of the first three-order dimensionless complex frequencies versus dimensionless moving speed are obtained, the effects of the aspect ratio, thickness ratio, the dimensionless moving speed and delay time on the dynamic behaviors of the axially moving viscoelastic rectangular plate with varying thickness are analyzed. When other parameters keep constant, with the decrease of thickness ratio, the real parts of the first three-order natural frequencies decrease, and the critical divergence speeds of various modes decrease too, moreover, whether the delay time is large or small, the frequencies are all complex numbers.

  3. Finite Difference Solution for Biopotentials of Axially Symmetric Cells

    Science.gov (United States)

    Klee, Maurice; Plonsey, Robert

    1972-01-01

    The finite difference equations necessary for calculating the three-dimensional, time-varying biopotentials within and surrounding axially symmetric cells are presented. The method of sucessive overrelaxation is employed to solve these equations and is shown to be rapidly convergent and accurate for the exemplary problem of a spheroidal cell under uniform field stimulation. PMID:4655665

  4. View of the Axial Field Spectrometer (R807)

    CERN Multimedia

    1980-01-01

    In this view of the Axial Field Spectrometer at I8, the vertical uranium/scintillator hadron calorimeter (just left of centre) is retracted to give access to the cylindrical central drift chamber. The yellow iron structure served as a filter to identify muons, with MWPCs and the array of Cherenkov counters to the right.

  5. Axial dispersion in flowing red blood cell suspensions

    Science.gov (United States)

    Podgorski, Thomas; Losserand, Sylvain; Coupier, Gwennou

    2016-11-01

    A key parameter in blood microcirculation is the transit time of red blood cells (RBCs) through an organ, which can influence the efficiency of gas exchange and oxygen availability. A large dispersion of this transit time is observed in vivo and is partly due to the axial dispersion in the flowing suspension. In the classic Taylor-Aris example of a solute flowing in a tube, the combination of molecular diffusion and parabolic velocity profile leads to enhanced axial dispersion. In suspensions of non-Brownian deformable bodies such as RBCs, axial dispersion is governed by a combination of shear induced migration and shear-induced diffusion arising from hydrodynamic interactions. We revisit this problem in the case of RBC pulses flowing in a microchannel and show that the axial dispersion of the pulse eventually saturates with a final extension that depends directly on RBC mechanical properties. The result is especially interesting in the dilute limit since the final pulse length depends only on the channel width, exponent of the migration law and dimensionless migration velocity. In continuous flow, the dispersion of transit times is the result of complex cell-cell and cell-wall interactions and is strongy influenced by the polydispersity of the blood sample. The authors acknowledge support from LabEx TEC21 and CNES.

  6. Periodicity effects of axial waves in elastic compound rods

    DEFF Research Database (Denmark)

    Nielsen, R. B.; Sorokin, S. V.

    2015-01-01

    Floquet analysis is applied to the Bernoulli-Euler model for axial waves in a periodic rod. Explicit asymptotic formulae for the stop band borders are given and the topology of the stop band pattern is explained. Eigenfrequencies of the symmetric unit cell are determined by the Phase-closure Prin...

  7. Experimental testing of axial induction based control strategies for wake control and wind farm optimization

    Science.gov (United States)

    Bartl, J.; Sætran, L.

    2016-09-01

    In state-of-the-art wind farms each turbine is controlled individually aiming for optimum turbine power not considering wake effects on downstream turbines. Wind farm control concepts aim for optimizing the overall power output of the farm taking wake interactions between the individual turbines into account. This experimental wind tunnel study investigates axial induction based control concepts. It is examined how the total array efficiency of two in-line model turbines is affected when the upstream turbine's tip speed ratio (λcontrol) or blade pitch angle (β-control) is modified. The focus is particularly directed on how the wake flow behind the upstream rotor is affected when its axial induction is reduced in order to leave more kinetic energy in the wake to be recovered by a downstream turbine. It is shown that the radial distribution of kinetic energy in the wake area can be controlled by modifying the upstream turbine's tip speed ratio. By pitching out the upstream turbine's blades, however, the available kinetic energy in the wake is increased at an equal rate over the entire blade span. Furthermore, the total array efficiency of the two turbine setup is mapped depending on the upstream turbines tip speed ratio and pitch angle. For a small turbine separation distance of x/D=3 the downstream turbine is able to recover the major part of the power lost on the upstream turbine. However, no significant increase in the two-turbine array efficiency is achieved by altering the upstream turbine's operation point away from its optimum.

  8. Uni-axial compaction of a granular material

    Science.gov (United States)

    Morland, L. W.; Sawicki, A.; Milne, P. C.

    1993-11-01

    S HEARING OF GRANULAR materials causes rearrangement of the granular structure which induces irreversible volume decrease and shear strain, in addition to reversible strain. The model adopted describes the reversible compression and shear by hypoelastic laws, and the irreversible compaction and shear by evolutionary laws. The latter are differential relations defining the progress of irreversible strain as an appropriate time-independent monotonie loading parameter increases, which incorporate dependence on the current state, and which prescribe a direction for the irreversible shear strain increment. The model is described by four material functions and two material constants, and has been shown to determine valid initial response to applied shear stress. We apply the model to the compaction of a granular material in uni-axial strain, which is described by two simultaneous differential equations for the axial stress and compaction with the axial strain as independent variable, together with algebraic relations for the pressure and lateral stress. The equation forms for loading-increasing axial stress—and unloading—decreasing axial stress-are distinct. Reformulation as differential equations for the pressure and the principal stress difference shows that the pressure derivative depends only on two of the material functions and one constant. The axial strain and lateral stress measured during a complete load-unload cycle on a sand determine the pressure and stress difference derivatives which are correlated directly with the model differential relations. Two material functions and one constant are determined by an optimization procedure from the complete loadunload ressure data, then the remaining two functions and constant from the stress difference data. Solution of the resulting model differential equations reproduces accurately the axial strain and lateral stress variations during the experimental loading cycle. In addition, model predictions for load

  9. Acupuncture Injection Combined with Electrokinetic Injection for Polydimethylsiloxane Microfluidic Devices

    Directory of Open Access Journals (Sweden)

    Ji Won Ha

    2017-01-01

    Full Text Available We recently reported acupuncture sample injection that leads to reproducible injection of nL-scale sample segments into a polydimethylsiloxane (PDMS microchannel for microchip capillary electrophoresis. The advantages of the acupuncture injection in microchip capillary electrophoresis include capability of minimizing sample loss and voltage control hardware and capability of introducing sample plugs into any desired position of a microchannel. However, the challenge in the previous study was to achieve reproducible, pL-scale sample injections into PDMS microchannels. In the present study, we introduce an acupuncture injection technique combined with electrokinetic injection (AICEI technique to inject pL-scale sample segments for microchip capillary electrophoresis. We carried out the capillary zone electrophoresis (CZE separation of FITC and fluorescein, and the mixture of 10 μM FITC and 10 μM fluorescein was separated completely by using the AICEI method.

  10. Acupuncture Injection Combined with Electrokinetic Injection for Polydimethylsiloxane Microfluidic Devices

    Science.gov (United States)

    2017-01-01

    We recently reported acupuncture sample injection that leads to reproducible injection of nL-scale sample segments into a polydimethylsiloxane (PDMS) microchannel for microchip capillary electrophoresis. The advantages of the acupuncture injection in microchip capillary electrophoresis include capability of minimizing sample loss and voltage control hardware and capability of introducing sample plugs into any desired position of a microchannel. However, the challenge in the previous study was to achieve reproducible, pL-scale sample injections into PDMS microchannels. In the present study, we introduce an acupuncture injection technique combined with electrokinetic injection (AICEI) technique to inject pL-scale sample segments for microchip capillary electrophoresis. We carried out the capillary zone electrophoresis (CZE) separation of FITC and fluorescein, and the mixture of 10 μM FITC and 10 μM fluorescein was separated completely by using the AICEI method. PMID:28326222

  11. Association between axial length and horizontal and vertical globe diameters.

    Science.gov (United States)

    Jonas, Jost B; Ohno-Matsui, Kyoko; Holbach, Leonard; Panda-Jonas, Songhomitra

    2017-02-01

    To assess relationships between axial length and the horizontal and vertical globe diameters. The study consisted of enucleated human eyes. The horizontal, vertical, and sagittal diameters were measured. The study included 135 globes removed because of malignant uveal melanoma (111 globes) or end-stage painful glaucoma (n = 24 eyes). Mean axial, horizontal, and vertical diameters were 24.6 ± 2.6 mm (range: 20-35 mm), 23.7 ± 1.4 mm (range: 21-29 mm) and 23.7 ± 1.4 mm (range: 20-29 mm) respectively. The horizontal diameter and vertical diameter did not differ significantly (P = 0.92), while both were significantly (P globe diameter (P globe diameter = 0.84 × horizontal globe diameter + 3.69). The axial diameter was significantly (P 24 mm, the horizontal and vertical globe diameter increased by a lower amount of 0.19 and 0.21 mm, respectively, for each mm increase in axial diameter. Myopic enlargement of the globe beyond an axial length of 24 mm takes place predominantly in the sagittal axis, leading to a change in the globe form from a sphere to an elongated form. It fits with the notion that myopic elongation may occur by an elongation of the eye walls in regions close to the globe's equator.

  12. High-resolution axial MR imaging of tibial stress injuries

    Directory of Open Access Journals (Sweden)

    Mammoto Takeo

    2012-05-01

    Full Text Available Abstract Purpose To evaluate the relative involvement of tibial stress injuries using high-resolution axial MR imaging and the correlation with MR and radiographic images. Methods A total of 33 patients with exercise-induced tibial pain were evaluated. All patients underwent radiograph and high-resolution axial MR imaging. Radiographs were taken at initial presentation and 4 weeks later. High-resolution MR axial images were obtained using a microscopy surface coil with 60 × 60 mm field of view on a 1.5T MR unit. All images were evaluated for abnormal signals of the periosteum, cortex and bone marrow. Results Nineteen patients showed no periosteal reaction at initial and follow-up radiographs. MR imaging showed abnormal signals in the periosteal tissue and partially abnormal signals in the bone marrow. In 7 patients, periosteal reaction was not seen at initial radiograph, but was detected at follow-up radiograph. MR imaging showed abnormal signals in the periosteal tissue and entire bone marrow. Abnormal signals in the cortex were found in 6 patients. The remaining 7 showed periosteal reactions at initial radiograph. MR imaging showed abnormal signals in the periosteal tissue in 6 patients. Abnormal signals were seen in the partial and entire bone marrow in 4 and 3 patients, respectively. Conclusions Bone marrow abnormalities in high-resolution axial MR imaging were related to periosteal reactions at follow-up radiograph. Bone marrow abnormalities might predict later periosteal reactions, suggesting shin splints or stress fractures. High-resolution axial MR imaging is useful in early discrimination of tibial stress injuries.

  13. SQL Injection Defenses

    CERN Document Server

    Nystrom, Martin

    2007-01-01

    This Short Cut introduces you to how SQL injection vulnerabilities work, what makes applications vulnerable, and how to protect them. It helps you find your vulnerabilities with analysis and testing tools and describes simple approaches for fixing them in the most popular web-programming languages. This Short Cut also helps you protect your live applications by describing how to monitor for and block attacks before your data is stolen. Hacking is an increasingly criminal enterprise, and web applications are an attractive path to identity theft. If the applications you build, manage, or guar

  14. MKI UFOs at Injection

    CERN Document Server

    Baer, T; Bartmann, W; Bracco, C; Carlier, E; Chanavat, C; Drosdal, L; Garrel, N; Goddard, B; Kain, V; Mertens, V; Uythoven, J; Wenninger, J; Zerlauth, M

    2011-01-01

    During the MD, the production mechanism of UFOs at the injection kicker magnets (MKIs) was studied. This was done by pulsing the MKIs on a gap in the circulating beam, which led to an increased number of UFOs. In total 43 UFO type beam loss patterns at the MKIs were observed during the MD. The MD showed that pulsing the MKIs directly induces UFO type beam loss patterns. From the temporal characteristics of the loss profile, estimations about the dynamics of the UFOs are made.

  15. Flow Injection Analysis: A Revolution in Modern Analytical Chemistry

    DEFF Research Database (Denmark)

    Hansen, Elo Harald

    1996-01-01

    A review is made of the fundamentals of Flow Injection Analysis (FIA), and the versatility and applicability of this analytical concept is demonstrated by a series of examples, comprizing the use of different types of FIA-manifolds and various detection devices (optical and electrochemical). Emph...

  16. Evaluation of the impact of viscosity, injection volume, and injection flow rate on subcutaneous injection tolerance

    Directory of Open Access Journals (Sweden)

    Berteau C

    2015-11-01

    Full Text Available Cecile Berteau,1 Orchidée Filipe-Santos,1 Tao Wang,2 Humberto E Rojas,2 Corinne Granger,1 Florence Schwarzenbach1 1Becton-Dickinson Medical Pharmaceutical Systems, Le Pont de Claix, France; 2Eli Lilly and Company, Indianapolis, IN, USA Aim: The primary objective of this study was to evaluate the impact of fluid injection viscosity in combination with different injection volumes and flow rates on subcutaneous (SC injection pain tolerance. Methods: The study was a single-center, comparative, randomized, crossover, Phase I study in 24 healthy adults. Each participant received six injections in the abdomen area of either a 2 or 3 mL placebo solution, with three different fluid viscosities (1, 8–10, and 15–20 cP combined with two different injection flow rates (0.02 and 0.3 mL/s. All injections were performed with 50 mL syringes and 27G, 6 mm needles. Perceived injection pain was assessed using a 100 mm visual analog scale (VAS (0 mm/no pain, 100 mm/extreme pain. The location and depth of the injected fluid was assessed through 2D ultrasound echography images. Results: Viscosity levels had significant impact on perceived injection pain (P=0.0003. Specifically, less pain was associated with high viscosity (VAS =12.6 mm than medium (VAS =16.6 mm or low (VAS =22.1 mm viscosities, with a significant difference between high and low viscosities (P=0.0002. Target injection volume of 2 or 3 mL was demonstrated to have no significant impact on perceived injection pain (P=0.89. Slow (0.02 mL/s or fast (0.30 mL/s injection rates also showed no significant impact on perceived pain during SC injection (P=0.79. In 92% of injections, the injected fluid was located exclusively in SC tissue whereas the remaining injected fluids were found located in SC and/or intradermal layers. Conclusion: The results of this study suggest that solutions of up to 3 mL and up to 15–20 cP injected into the abdomen within 10 seconds are well tolerated without pain. High

  17. Advanced target concepts for production of radioactive ions and neutrino beams

    CERN Document Server

    Ravn, H L

    2003-01-01

    The 1-20 MW of proton beam power which modern accelerator technology put at our disposal for production of intense secondary beams presents a major technically challenge to the production targets. A conceptual design is presented for a high-power pion production target and collection system, which was originally suggested to be used as the source for the proposed CERN muon-neutrino factory. It will be shown that the major parts of this target could also serve as an efficient spallation neutron source for production of 6He and fission products in the two-step converter-target concept. The heart of the system consists of a free surface Mercury jet with a high axial velocity, which allows the heat to be carried away efficiently from the production region. For the neutrino factory the secondary pions are collected and injected into the pion decay-channel by means of a magnetic horn. For the radioactive ion-beam facility the Hg-jet is surrounded by the high-temperature ISOL production-target. The suggested mechani...

  18. On L-injective Covers

    Institute of Scientific and Technical Information of China (English)

    周德旭

    2004-01-01

    We use the class of L-injective modules to define L-injective covers, and provide the characterizations of L-injective covers by the properties of kernels of homomorphisms. We prove that the right L-noetherian right L-hereditary ring is just such that every right R-module has an L-injective cover which is monic. We also use kernels of homomorphisms to investigate L-simple L-injective covers and give some constructions ofL-simple L-iniective covers.

  19. [Use the hyaluronic acid according to the concept Face Recurve: vacuum technical and interpores technical].

    Science.gov (United States)

    Le Louarn, C

    2008-06-01

    Two new applications of the Face Recurve concept to hyaluronic acid injections are: --the vacuum technique, for deep and for retro muscular injections, which is performed to avoid diffusion and increase precision; --the interpore technique for superficial injections, which is performed in the epidermis to macroscopically erase the interpore wrinkle and to decrease the pore diameter.

  20. Flow Injection Analysis

    DEFF Research Database (Denmark)

    Hansen, Elo Harald

    2004-01-01

    This chapter provides an introduction to automated chemical analysis, which essentially can be divided into two groups: batch assays, where the solution is stationary while the container is moved through a number of stations where various unit operations performed; and continuous-flow procedures,......, but it permits thr execution of novel and unique analytical procedures which are difficult or even impossible by conventional means. The performance and applicability of FIA, SI and LOV are illustrated by a series of practical examples.......This chapter provides an introduction to automated chemical analysis, which essentially can be divided into two groups: batch assays, where the solution is stationary while the container is moved through a number of stations where various unit operations performed; and continuous-flow procedures......, where the system is stationary while the solution moves through a set of conduits in which all required manipulations are performed. Emphasis is placed on flow injection analysis (FIA) and its further developments, that is, sequential injection analysis (SIA) and the Lab-on-Valve (LOV) approach. Since...

  1. Epidemiology of Injection Drug Use

    Science.gov (United States)

    Arruda, Nelson; Bruneau, Julie; Jutras-Aswad, Didier

    2016-01-01

    After more than 30 years of research, numerous studies have shown that injection drug use is associated with a wide range of adverse health outcomes such as drug overdoses, drug-related suicidal behaviours, comorbid psychiatric disorders, bloodborne pathogens and other infectious diseases, and traumas. This review explores new trends and prominent issues associated with injection drug use. The dynamic nature of injection drug use is underlined by examining its recent trends and changing patterns in Canada and other “high-income countries.” Three research topics that could further contribute to the development of comprehensive prevention and intervention strategies aimed at people who inject drugs are also discussed: risk behaviours associated with the injection of prescription opioids, binge injection drug use, and mental health problems as determinants of injection risk behaviours. PMID:27254088

  2. Direct injection into the IsoDAR Cyclotron using a RFQ

    Science.gov (United States)

    Axani, Spencer; IsoDAR Collaboration

    2015-04-01

    Beginning in the 1970s, the use of Radio Frequency Quadrupoles (RFQs) has been pervasive in linear accelerators in order to accelerate, bunch, and separate ion species. Current research suggests this may be an ideal way to inject a low energy H2+ beam axially into a cyclotron. The IsoDAR (Isotope Decay At Rest) experiment aims to implement this injection system in order to achieve higher Low Energy Beam Transport (LEBT) efficiencies and ultimately construct a novel compact neutrino factory to test the hypothesis of sterile neutrinos. This talk will focus on the research and development needed to implement a RFQ into the IsoDAR experiment.

  3. The Pulse Line Ion Accelerator Concept

    Energy Technology Data Exchange (ETDEWEB)

    Briggs, Richard J.

    2006-02-15

    The Pulse Line Ion Accelerator concept was motivated by the desire for an inexpensive way to accelerate intense short pulse heavy ion beams to regimes of interest for studies of High Energy Density Physics and Warm Dense Matter. A pulse power driver applied at one end of a helical pulse line creates a traveling wave pulse that accelerates and axially confines the heavy ion beam pulse. Acceleration scenarios with constant parameter helical lines are described which result in output energies of a single stage much larger than the several hundred kilovolt peak voltages on the line, with a goal of 3-5 MeV/meter acceleration gradients. The concept might be described crudely as an ''air core'' induction linac where the PFN is integrated into the beam line so the accelerating voltage pulse can move along with the ions to get voltage multiplication.

  4. EFFICACY OF TRANSFORAMINAL EPIDURAL STEROID INJECTION IN LUMBOSACRAL RADICULOPATHY

    Directory of Open Access Journals (Sweden)

    Saheel

    2016-02-01

    Full Text Available BACKGROUND Lumbosacral radiculopathy is a common medical and socioeconomic problem with a lifetime prevalence estimated to be around 40%-60%. In 1930, Evans reported that sciatica could be treated by epidural injection. The use of epidural corticosteroid injection for the treatment of axial and radicular back pain was first reported in 1953. Lumbar Transforminal Epidural Steroid Injections (TFESIs are performed to provide symptomatic relief in patients with radicular pain. A transforaminal epidural steroid injection (TFESI using a small volume of local anaesthetic will anaesthetize the spinal nerve and also partially anaesthetize the dura, the posterior longitudinal ligament, the intervertebral disc and facet joint. For these reasons, fluoroscopy-guided TFESI has become the preferred approach to epidural space. AIMS AND OBJECTIVES To study the role of transforaminal epidural steroid injection in management of radiculopathy. SETTINGS AND DESIGN This prospective study was conducted in the Department of Orthopaedics, SKIMS Medical College and Hospital, Bemina, Srinagar, J and K, India, for a 2-year period from November 2012 to October 2014; 110 cases, both male and female in the age group of 20-60 years having back pain with radiculopathy of varied types and duration without neurodeficit were enrolled in the study. MATERIALS AND METHODS After selecting a patient for giving transforaminal block, we used a local anaesthetic (2% Xylocaine. Contrast media, e.g. Iohexol was used to demarcate the correct positioning of the needle. A spinal needle (20-25 gauge and 5mL syringe were used to deliver the drug. CONCLUSION Transforaminal epidural steroid injections with long acting anaesthetic is an excellent form of conservative treatment in management of low back ache with radicular pain. It is relatively safe, simple, economical and shortens the time of recovery from severe pain, avoids risks and complications of surgery and also avoids long periods of bed

  5. Development of High Efficiency and Low Emission Low Temperature Combustion Diesel Engine with Direct EGR Injection

    Science.gov (United States)

    Ho, R. J.; Kumaran, P.; Yusoff, M. Z.

    2016-03-01

    Focus on energy and environmental sustainability policy has put automotive research & development directed to developing high efficiency and low pollutant power train. Diffused flame controlled diesel combustion has reach its limitation and has driven R&D to explore other modes of combustions. Known effective mode of combustion to reduce emission are Low temperature combustion (LTC) and homogeneous charge combustion ignition by suppressing Nitrogen Oxide(NOx) and Particulate Matter (PM) formation. The key control to meet this requirement are chemical composition and distribution of fuel and gas during a combustion process. Most research to accomplish this goal is done by manipulating injected mass flow rate and varying indirect EGR through intake manifold. This research paper shows viable alternative direct combustion control via co-axial direct EGR injection with fuel injection process. A simulation study with OpenFOAM is conducted by varying EGR injection velocity and direct EGR injector diameter performed with under two conditions with non-combustion and combustion. n-heptane (C7H16) is used as surrogate fuel together with 57 species 290 semi-detailed chemical kinetic model developed by Chalmers University is used for combustion simulation. Simulation result indicates viability of co-axial EGR injection as a method for low temperature combustion control.

  6. Modelling larval transport in a axial convergence front

    Science.gov (United States)

    Robins, P.

    2010-12-01

    Marine larvae exhibit different vertical swimming behaviours, synchronised by factors such as tidal currents and daylight, in order to aid retention near the parent populations and hence promote production, avoid predation, or to stimulate digestion. This paper explores two types of larval migration in an estuarine axial convergent front which is an important circulatory mechanism in many coastal regions where larvae are concentrated. A parallelised, three-dimensional, ocean model was applied to an idealised estuarine channel which was parameterised from observations of an axial convergent front which occurs in the Conwy Estuary, U.K. (Nunes and Simpson, 1985). The model successfully simulates the bilateral cross-sectional recirculation of an axial convergent front, which has been attributed to lateral density gradients established by the interaction of the lateral shear of the longitudinal currents with the axial salinity gradients. On the flood tide, there is surface axial convergence whereas on the ebb tide, there is (weaker) surface divergence. Further simulations with increased/decreased tidal velocities and with stronger/weaker axial salinity gradients are planned so that the effects of a changing climate on the secondary flow can be understood. Three-dimensional Lagrangian Particle Tracking Models (PTMs) have been developed which use the simulated velocity fields to track larvae in the estuarine channel. The PTMs take into account the vertical migrations of two shellfish species that are commonly found in the Conwy Estuary: (i) tidal migration of the common shore crab (Carcinus maenas) and (ii), diel (daily) migration of the Great scallop (Pecten maximus). These migration behaviours are perhaps the most widespread amongst shellfish larvae and have been compared with passive (drifting) particles in order to assess their relative importance in terms of larval transport. Preliminary results suggest that the net along-estuary dispersal over a typical larval

  7. Identification of animal movement patterns using tri-axial magnetometry.

    Science.gov (United States)

    Williams, Hannah J; Holton, Mark D; Shepard, Emily L C; Largey, Nicola; Norman, Brad; Ryan, Peter G; Duriez, Olivier; Scantlebury, Michael; Quintana, Flavio; Magowan, Elizabeth A; Marks, Nikki J; Alagaili, Abdulaziz N; Bennett, Nigel C; Wilson, Rory P

    2017-01-01

    Accelerometers are powerful sensors in many bio-logging devices, and are increasingly allowing researchers to investigate the performance, behaviour, energy expenditure and even state, of free-living animals. Another sensor commonly used in animal-attached loggers is the magnetometer, which has been primarily used in dead-reckoning or inertial measurement tags, but little outside that. We examine the potential of magnetometers for helping elucidate the behaviour of animals in a manner analogous to, but very different from, accelerometers. The particular responses of magnetometers to movement means that there are instances when they can resolve behaviours that are not easily perceived using accelerometers. We calibrated the tri-axial magnetometer to rotations in each axis of movement and constructed 3-dimensional plots to inspect these stylised movements. Using the tri-axial data of Daily Diary tags, attached to individuals of number of animal species as they perform different behaviours, we used these 3-d plots to develop a framework with which tri-axial magnetometry data can be examined and introduce metrics that should help quantify movement and behaviour.. Tri-axial magnetometry data reveal patterns in movement at various scales of rotation that are not always evident in acceleration data. Some of these patterns may be obscure until visualised in 3D space as tri-axial spherical plots (m-spheres). A tag-fitted animal that rotates in heading while adopting a constant body attitude produces a ring of data around the pole of the m-sphere that we define as its Normal Operational Plane (NOP). Data that do not lie on this ring are created by postural rotations of the animal as it pitches and/or rolls. Consequently, stereotyped behaviours appear as specific trajectories on the sphere (m-prints), reflecting conserved sequences of postural changes (and/or angular velocities), which result from the precise relationship between body attitude and heading. This novel

  8. The anomalous transport of axial charge: topological vs non-topological fluctuations

    CERN Document Server

    Iatrakis, Ioannis; Yin, Yi

    2015-01-01

    Axial charge imbalance is an essential ingredient in novel effects associated with chiral anomaly such as chiral magnetic effects (CME). In a non-Abelian plasma with chiral fermions, local axial charge can be generated a) by topological fluctuations which would create domains with non-zero winding number b) by conventional non-topological thermal fluctuations. We provide a holographic evaluations of medium's response to dynamically generated axial charge density in hydrodynamic limit and examine if medium's response depends on the microscopic origins of axial charge imbalance. We show a local domain with non-zero winding number would induce a non-dissipative axial current due to chiral anomaly. We illustrate holographically that a local axial charge imbalance would be damped out with the damping rate related to Chern-Simon diffusive constant. By computing chiral magnetic current in the presence of dynamically generated axial charge density, we found that the ratio of CME current over the axial charge density ...

  9. Investigation on a procedure for optimal axial depth of cut accuracy in micromilling

    DEFF Research Database (Denmark)

    Bissacco, Giuliano; Hansen, Hans Nørgaard; De Chiffre, Leonardo

    2005-01-01

    On the basis of a previously developed procedure for control of axial depth of cut in high accuracy micromilling operations, this paper presents an investigation on the estimation of the uncertainty of the set axial depth of cut....

  10. Modular injection systems for miniature engines

    Science.gov (United States)

    Cochran, Mike

    1992-07-01

    Mission requirements for Kinetic Energy Weapons will require miniaturization of current vehicle propulsion systems for future Space Defence Iniative Programs. A modular injection system (MIS) valve is presented which will decrease cost, size and weight of miniaturized storable bipropellant rocket engines and features two poppet-type propellant valve modules pneumatically linked to a pilot solenoid module. A prototype modular injection valve sized for 100lbf thrust was designed and is being tested to show lower costs, fewer moving parts and a reduction in weight and size. Results show that this valve meets objectives of one-half weight, one-half cost and one-fifth the envelopment of current production valves. Studies indicate that a cruciform configuration of four nominal 100lbf thrust engines can be controlled by four modular injection valve systems in a single housing of less than 1.0 m3. Following further development and correlation of results this concept may be scaled to control four higher thrust engines.

  11. Using Mindfulness to Develop Health Education Strategies for Blood Borne Virus Prevention in Injecting Drug Use

    Science.gov (United States)

    Treloar, Carla; Laybutt, Becky; Carruthers, Susan

    2010-01-01

    Aims: Prevention education has had limited success in reducing transmission of blood borne virus among people who inject drugs. Innovative approaches to prevention education are required. Method: This study used video recordings of injecting episodes and interviews with participants reviewing their video recordings to explore the concept of…

  12. Evaluation of the impact of viscosity, injection volume, and injection flow rate on subcutaneous injection tolerance.

    Science.gov (United States)

    Berteau, Cecile; Filipe-Santos, Orchidée; Wang, Tao; Rojas, Humberto E; Granger, Corinne; Schwarzenbach, Florence

    2015-01-01

    The primary objective of this study was to evaluate the impact of fluid injection viscosity in combination with different injection volumes and flow rates on subcutaneous (SC) injection pain tolerance. The study was a single-center, comparative, randomized, crossover, Phase I study in 24 healthy adults. Each participant received six injections in the abdomen area of either a 2 or 3 mL placebo solution, with three different fluid viscosities (1, 8-10, and 15-20 cP) combined with two different injection flow rates (0.02 and 0.3 mL/s). All injections were performed with 50 mL syringes and 27G, 6 mm needles. Perceived injection pain was assessed using a 100 mm visual analog scale (VAS) (0 mm/no pain, 100 mm/extreme pain). The location and depth of the injected fluid was assessed through 2D ultrasound echography images. Viscosity levels had significant impact on perceived injection pain (P=0.0003). Specifically, less pain was associated with high viscosity (VAS =12.6 mm) than medium (VAS =16.6 mm) or low (VAS =22.1 mm) viscosities, with a significant difference between high and low viscosities (P=0.0002). Target injection volume of 2 or 3 mL was demonstrated to have no significant impact on perceived injection pain (P=0.89). Slow (0.02 mL/s) or fast (0.30 mL/s) injection rates also showed no significant impact on perceived pain during SC injection (P=0.79). In 92% of injections, the injected fluid was located exclusively in SC tissue whereas the remaining injected fluids were found located in SC and/or intradermal layers. The results of this study suggest that solutions of up to 3 mL and up to 15-20 cP injected into the abdomen within 10 seconds are well tolerated without pain. High viscosity injections were shown to be the most tolerated, whereas injection volume and flow rates did not impact perceived pain.

  13. Ritual relieved axial dystonia triggered by gaze-evoked amaurosis.

    Science.gov (United States)

    Jacome, D E

    1997-11-01

    A woman with chronic posttraumatic axial lateropulsion cervical dystonia ("belly dancer's head") found relief of her spontaneous dystonic spasms by the sequential performance of an elaborate motor ritual. During an episode of left optic papillitis caused by central retinal vein occlusion, gaze-evoked amaurosis of the left eye developed, preceded by achromatopsia, during left lateral gaze. Gaze-evoked amaurosis triggered axial dystonia, which was followed by her unique, stereotyped, dystonia-relieving ritual that simulated a slow dance. Visual symptoms improved progressively in 1 year. Eventually, she was unable to trigger her dystonia by eye movements. Spontaneous dystonia remained otherwise unchanged from before the episode of papillitis and was still relieved by her unique ritual.

  14. Instability of meridional axial system in f(R) gravity

    Energy Technology Data Exchange (ETDEWEB)

    Sharif, M.; Yousaf, Z. [University of the Punjab, Department of Mathematics, Lahore (Pakistan)

    2015-05-15

    We analyze the dynamical instability of a non-static reflection axial stellar structure by taking into account the generalized Euler equation in metric f(R) gravity. Such an equation is obtained by contracting the Bianchi identities of the usual anisotropic and effective stress-energy tensors, which after using a radial perturbation technique gives a modified collapse equation. In the realm of the R + εR{sup n} gravity model, we investigate instability constraints at Newtonian and post-Newtonian approximations. We find that the instability of a meridional axial self-gravitating system depends upon the static profile of the structure coefficients, while f(R) extra curvature terms induce the stability of the evolving celestial body. (orig.)

  15. Reduced aniseikonia in axial anisometropia with contact lens correction.

    Science.gov (United States)

    Winn, B; Ackerley, R G; Brown, C A; Murray, F K; Prais, J; St John, M F

    1988-01-01

    Aniseikonia, although present in isometropia, is associated principally with anisometropia and is widely thought to be the result of differences in the retinal image size presented to each eye. This assumes that equating retinal image size results in congruous cortical images. To test this assumption 1 refractive and 17 axial anisometropic subjects were examined to determine the aniseikonia present when corrected with spectacles and contact lenses. Contrary to many previous predictions, based upon Knapp's Law, the presence of equal retinal images resulted in larger aniseikonias than observed when the eyes were presented with unequal retinal images. This suggests that non-optical components have a significant role in the production of the cortical image, and this therefore requires a shift in the way the management of anisometropia is considered clinically. Contact lens correction maintains the aniseikonia at a minimum level in axial as well as refractive anisometropia and offers the clinician an acceptable practical alternative when prescribing for these patients.

  16. Laboratory Test Setup for Cyclic Axially Loaded Piles in Sand

    DEFF Research Database (Denmark)

    Thomassen, Kristina; Ibsen, Lars Bo; Andersen, Lars Vabbersgaard

    2017-01-01

    conditions for all tests. For verifications purposes six static tension tests conducted at three different vertical effective stress levels of 0, 35 and 70 kPa. The load-displacement curves showed that the test setup provides repeatable test results. A preliminary comparison between the unit shaft friction......This paper presents a comprehensive description and the considerations regarding the design of a new laboratory test setup for testing cyclic axially loaded piles in sand. The test setup aims at analysing the effect of axial one-way cyclic loading on pile capacity and accumulated displacements....... Another aim was to test a large diameter pile segment with dimensions resembling full-scale piles to model the interface properties between pile and sand correctly. The pile segment was an open-ended steel pipe pile with a diameter of 0.5 m and a length of 1 m. The sand conditions resembled the dense sand...

  17. Investigation of Valve Plate in Water Hydraulic Axial Piston Motor

    Institute of Scientific and Technical Information of China (English)

    聂松林; 李壮云; 等

    2002-01-01

    This paper has introduced the developments of water hydraulic axial piston equipments.According to the effects of physicochemical properties of water on water hydraulic components,a novel valve plate for water hydraulic axial motor has been put forward,whose moment exerted by the fluid field between valve plate and bearing plate is balanced entirely.The material screening experiment of valve plate is done on the test rig.Through numerical simulation the effects of some geometry parameters on the performance of water hydraulic motor have been studied.The silencing grooves on the valve plate in water hydraulic motor can reduce the pressure shock and the occurrence of cavitation effectively.It is evident that the appropriate structure should change the wear status between matching paris and reduces the wear and specific pressure of the matching pairs.The specimen with the new type valve plate is used in a tool system.

  18. Improving axial depth of cut accuracy in micromilling

    DEFF Research Database (Denmark)

    Bissacco, Giuliano; Hansen, Hans Nørgaard; De Chiffre, Leonardo

    2004-01-01

    and their rapid warming and cooling, which prevent the achievement of a steady state. Several other factors, independent on the tool-workpiece interaction, influence the machining accuracy. The cutting parameter most heavily affected is the axial depth of cut which is the most critical when using micro end mills......In order to maintain an optimum cutting speed, the reduction of mill diameters requires machine tools with high rotational speed capabilities. A solution to update existing machine tools is the use of high speed attached spindles. Major drawbacks of these attachments are the high thermal expansion......, due to the easy breakage particularly when milling on hard materials. Typical values for the errors on the control of the axial depth of cut are in the order of 50 microns [1], [2], while the aimed depth of cut can be as low as 5 microns. As a result, micromilling cannot enter yet normal workshops...

  19. Effect of axial mixing on RDC and PSE columns performance

    CERN Document Server

    Bastani, D

    2001-01-01

    Using the experimental data obtained from two RDC columns at two different sizes (7.62 and 21.9 cm) and one PSE column with 21.5 cm size, the effect of axial mixing on the performance of these columns was studied. Comparison between the experimental and theoretical (neglecting the axial mixing) number of transfer units indicates that, this effect in PSE columns is more than RDC columns (400% and 200% respectively). These results show that this effect can increase the height of the PSE column up to 4 times for a specific efficiency. Also the results show that this effect is more in law interfacial tension systems, which shows no need of application of agitation facilities when these systems are used.

  20. [Inflammatory spinal diseases: axial spondyloarthritis : Central importance of imaging].

    Science.gov (United States)

    Baraliakos, X; Fruth, M; Kiltz, U; Braun, J

    2017-03-01

    The diagnosis of axial spondyloarthritis (axSpA) includes classical ankylosing spondylitis (AS) as well as earlier stages and abortive courses of the disease, in which structural alterations have not yet occurred. These are classified as non-radiographic axSpA (nr-axSpa). Inflammatory changes in the entire axial skeleton are characteristic for axSpA and can be visualized by magnetic resonance imaging (MRI), while in most patients structural alterations, such as new bone formation with syndesmophytes and ankylosis develop in the later course of the disease. These bony alterations can best be visualized by conventional radiography and by computed tomography. Certain MRI sequences are nowadays considered as the standard method for depiction of inflammatory changes in axSpA. The introduction of MRI has led to a paradigm shift for this disease because the inflammatory lesions characteristic for the disease can be visualized at an early stage using appropriate MRI sequences.