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  1. Renforcer la gestion financière publique au niveau du ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Renforcer la gestion financière publique au niveau du gouvernement de comté au Kenya. Ce projet aidera les comtés du Kenya à surmonter des défis importants découlant du transfert de certains pouvoirs détenus auparavant par le gouvernement central. L'objectif de l'équipe de recherche est de solidifier les capacités ...

  2. Une souplesse au niveau des droits de propriété intellectuelle ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    27 avr. 2016 ... Des constatations de recherche mènent au déploiement à l'échelle nationale de programmes de prévention du VIH au Botswana. Un nouveau projet de recherche remarquable sur la prévention du VIH chez les personnes qui sont dans « l'incapacité de choisir » (ce à quoi renvoie. Voir davantageDes ...

  3. Conception et réalisation de l'unité de décision du système de déclenchement de premier niveau du détecteur LHCb au LHC

    CERN Document Server

    Laubser, Julien

    2007-01-01

    Le detecteur LHCb est l'une des quatre experiences de physique des particules installees sur la nouvelle chaine d'acceleration LHC (Large Hadron Collider) du CERN a Geneve. Afin de reduire la quantite de donnees destinees au stockage pour les analyses hors ligne, un dispositif de selection en ligne des collisions interessantes selon la physique a etudier est mis en place en parallele de la chaine d'acquisition des donnees. Ce dispositif est compose d'un premier niveau(niveau 0) realise par un systeme electronique complexe et d'un second niveau de selection realise par informatique HLT (High Level Trigger). L'unite de decision de niveau 0 (L0DU) est le systeme central du niveau 0 de declenchement. L0DU prend la decision d'accepter ou de rejeter la collision pour ce premier niveau a partir d'une fraction d'informations issues des sous-detecteurs les plus rapides (432 bits a 80 MHz). L'unite de decision est un circuit imprime 16 couches integrant des composants de haute technologie de type FPGA (Field Programmab...

  4. Les changements sémantiques et les ambiguïtés au niveau du discours : l'exemple du fr. on

    Directory of Open Access Journals (Sweden)

    Winter-Froemel Esme

    2012-07-01

    Full Text Available Dans cette contribution sera analysé le changement sémantique du pronom impersonnel on qui acquiert une valeur de 1Pl dans le français parlé. Pour expliquer ce changement, nous nous intéresserons à des emplois précoces du pronom dans son sens novateur qui peuvent s'observer dès le XVIe siècle. Grâce à des analyses sémantiques et pragmatiques d'extraits de corpus (Frantext, on peut distinguer deux scénarios d'innovations potentiels (réanalyses sémantiques et actes de langage indirects. En même temps, on constate, dans les deux cas, une ambiguïté entre le sens ancien (qui est le sens impersonnel, soit générique ou gnomique, soit épisodique ou existentiel et le sens nouveau (de la 1Pl. Sur la base de cette observation, nous approfondirons ensuite nos réflexions sur le concept des bridging contexts (Evans & Wilkins 2000 et sur le concept de l'ambiguïté en proposant une distinction entre les ambiguïtés au niveau de la langue et les ambiguïtés au niveau du discours, ces dernières se révélant fondamentales pour expliquer le changement sémantique décrit. De même, nous montrerons de quelle manière les deux types d'ambiguïté se manifestent et interagissent à différents stades des changements linguistiques. Les réflexions et analyses suggèrent ainsi différentes voies par lesquelles les recherches sur les phénomènes d'ambiguïté peuvent présenter des apports prometteurs pour la modélisation des changements linguistiques en général.

  5. La tuberculose cutanée: observation de six cas confirmés au CHU ...

    African Journals Online (AJOL)

    La localisation cutanée de la maladie tuberculeuse demeure une forme rare et représente seulement 2,1 % des localisations. L'objet de cette étude est de rapporter le profil épidémiologique, anatomoclinique et évolutif des cas de tuberculose ganglio-cutanée diagnostiqués dans un CHU au Burkina Faso. La fréquence de ...

  6. Carcinome cutané de Merkel: apport de la TEP-TDM au18FDG ...

    African Journals Online (AJOL)

    Carcinome cutané de Merkel: apport de la TEP-TDM au18FDG. Guensi Amal, Taleb Sara, Cherkaoui Salhi Ghofrane, Ait Idir Malika, Houjami Majdouline, Sahraoui Souha, Benider Abdelatif, Touil Najoua, Benmoussa Ghita, Baroudi Zineb, Chikhaoui Nabil ...

  7. Pathologies cutanées vues au laboratoire d'anatomie pathologique ...

    African Journals Online (AJOL)

    Pathologies cutanées vues au laboratoire d'anatomie pathologique à Lomé, Togo. Tchin Darre, Abas Mouhari-Toure, Bayaki Saka, Efoé-ga Yawod Olivier Amouzou, Sassil Dare, Dadja Essoya Landoh, Koffi Amegbor, Palokinam Pitché, Gado Napo-Koura ...

  8. Radiotherapy for cutaneous cancers with xeroderma pigmentosum; Radiotherapie des cancers cutanes au cours du xeroderma pigmentosum

    Energy Technology Data Exchange (ETDEWEB)

    Ben Salah, H.; Bahri, M.; Turki, H.; Abdelmoula, M.; Frikha, M.; Daoud, J. [Service de radiotherapie, CHU Habib-Bourguiba, route Majida-Bouleila, 3029 Sfax (Tunisia)

    2011-08-15

    Purpose. - To analyze the therapeutic results of cutaneous cancers on xeroderma pigmentosum through a series of 15 patients treated by radiotherapy. Patients and methods. - Between 1993 and 2006, 15 patients with xeroderma pigmentosum and having cutaneous cancers were treated in the Radiotherapy Department of university hospital Habib-Bourguiba of Sfax in Tunisia. Seventy-three percent of the cases occurred in male patients and the mean age of appearance of the first tumour was 18.2 years. Tumour histology was squamous cell carcinoma in 74% of the cases. The total number of cutaneous tumours was 84. Ten patients had a surgical resection. Four patients did not respond to chemotherapy. The modality of irradiation was decided according to the size, thickness and localization of the tumour. The dose of radiotherapy was 60 Gy or equivalent with classic irradiation. Results. - The total number of lesions treated with radiotherapy was 64. Forty-three lesions were treated with contact-therapy, ten with brachytherapy and 11 with cobalt-therapy. The following acute complications were observed: cutaneous infection (53.3% of patients), radio-epithelitis (80% of patients) and necroses (33.3% of patients). Evaluation after treatment showed a clinical complete remission in 73% of the cases. Late effects were noted in seven cases: telangiectasia and cutaneous atrophy. A recurrence in the irradiated zone was observed in one case. A nodal metastasis was observed in two cases. Another patient presented lung metastases. After a median follow up of 37.2 months, four patients died, seven are alive with cutaneous cancer and four are alive with complete remission. Conclusion. - Radiotherapy is a possible and effective therapeutic alternative. Dose and methods are not defined for xeroderma pigmentosum. (authors)

  9. Différencier dans les jeux de balle: élaboration et application d'un outil d'évaluation du niveau de coordination des élèves au cycle de transition (CYT)

    OpenAIRE

    Schmitz, Jaqueline; Gianpaolo, Patelli

    2011-01-01

    L’éducation physique et sportive (EPS) dans le canton de Vaud est la seule discipline qui n’est pas sujette à l’évaluation par les notes. Elle ne participe donc pas au classement par niveau (VSO/VSG/VSB) du système scolaire vaudois. Cela signifie pour l’enseignant que ses classes ne sont pas organisées selon le niveau d’habileté des élèves. S’adapter aux besoins variés des élèves est donc le défi permanent du maître d’éducation physique et sportive. Comment peut-il donc différencier son...

  10. Diabète en milieu urbain de Ouagadougou au Burkina Faso: profil épidémiologique et niveau de perception de la population adulte

    Science.gov (United States)

    Millogo, Georges Rosario Christian; Yaméogo, Clément; Samandoulougou, André; Yaméogo, Nobila Valentin; Kologo, Koudougou Jonas; Toguyeni, Jean Yves; Zabsonré, Patrice

    2015-01-01

    Introduction L'accroissement rapide de la prévalence du diabète sucré en Afrique subsaharienne constitue un problème de santé public. L'Organisation Mondiale de la Santé (OMS) estime qu’à l'horizon 2025, l'augmentation la plus significative de la prévalence du diabète sera enregistrée dans les pays en développement. Ceux-ci devraient abriter 75% des patients diabétiques du monde. Outre ses complications métaboliques, le diabète est un facteur de risque cardiovasculaire majeur. Le but de notre étude était de decrire le profil épidémiologique du diabète et d’évaluer le niveau de perception de la maladie par une population africaine en milieu urb qwqain de Ouagadougou. Méthodes Le diabète a été défini chez tout sujet ayant une glycémie casuelle supérieure à 2 g/L ou une glycémie à jeun supérieur ou égale à 1,26 g/L (≥ 7 mmol/L) à deux controles d'une semaine d'intervalle. Etaient considérés diabétique, les sujets déjà suivis et ceux nouvellement dépistés par l'etude. Résultats L’étude a inclus 1532 personnes, d’âge compris entre 25 et 64 ans dont 55,6% d'hommes et 44,4% de femmes. L’âge moyen était 36,10 ± 11,19 ans. La tranche d’âge de 25 à 34 ans était la plus représentée avec une proportion de 57,1%. La glycémie moyenne était de 1,04 g/L, la proportion des femmes ayant une hyperglycémie était statistiquement plus importante que celle des hommes (p< 0,05). Près de 81,3% de la population ignoraient que le diabète était un facteur de risque cardiovasculaire. Conclusion Il est urgent de mettre en place un programme national de lutte contre le diabète sucré et les autres maladies non transmissibles au Burkina Faso. PMID:26524982

  11. Étude du comportement de smolts de saumon atlantique (Salmo salar L. au niveau de la prise d'eau de l'usine hydroélectrique de Pointis sur la Garonne et estimation de la dévalaison au niveau du barrage de Rodère

    Directory of Open Access Journals (Sweden)

    CROZE O.

    1999-04-01

    Full Text Available Une expérimentation a été menée en 1998 au niveau de la prise d'eau de l'usine hydroélectrique de Pointis, sur la Garonne, de manière à déterminer, grâce à la technique de radio-pistage, le meilleur emplacement d'un futur dispositif de dévalaison. Le suivi des déplacements de 28 smolts radiomarqués a mis en évidence que, dans des conditions hydrauliques peu marquées (vitesses de courant 1 jour et dépendent du débit du cours d'eau. Les vitesses de dévalaison dans les canaux d'amenée de Pointis (1,9 à 4,2 km/h et de Camon (2,5 à 7 km/h sont positivement corrélées aux vitesses de l'écoulement.

  12. Etude de la résistance aux antibiotiques des bactéries à Gram négatif non fermentantes au niveau du C.H.U de Tlemcen

    OpenAIRE

    LIAZID, Asma

    2011-01-01

    Les bacilles à Gram négatif non fermentants sont des bactéries pathogènes opportunistes responsables d’infections nosocomiales. La sensibilité à cinq β-lactamines, à trois aminosides et à une fluoroquinolone a été étudiée sur 63 souches isolées de 153 prélèvements au niveau de CHU de Tlemcen. Acinetobacter baumannii est une des espèces les plus impliquées dans les infections nosocomiales du fait de l’association de plusieurs mécanismes de résistance. Sur un total de 35 souches d’A. baumannii,...

  13. La micro-entreprise moyen de lutte contre la pauvreté: mise en évidence par application au niveau des régions tunisiennes = Micro-enterprises are the medium against poverty: Its application in Tunisian regions

    Directory of Open Access Journals (Sweden)

    Makram Gaaliche

    2013-12-01

    Full Text Available La contribution du secteur des micro-entreprises en Tunisie, dans la lutte contre la pauvreté, s’est manifestée de telle sorte que, tout accroissement du nombre d’unité de micro-entreprise entraîne une réduction du taux de pauvreté. En outre, il s’est avérée que la participation de ces petites unités dans la lutte contre la pauvreté, varie d’une région à une autre, selon le secteur d’activité y exerçantes. La détection d’une telle spécialisation sectorielle au niveau de la lutte contre la pauvreté, permet l’adoption de politiques régionales ciblées, destinées à encourager la création de micro-entreprises, au niveau des secteurs d’activité les plus pertinents.In Tunisia, the contribution of the microentreprises sector, in the fight against poverty, has appeared so that, every increasing in the number of the microentreprises involves a reduction of the poverty rate. In addition, it proved that the participation of these small unities in the fight against poverty varies from one area to another, according to the activity sectors. The detection of such sectoral specialization on the level of the fight against poverty, allows the adoption of targeted regional policies, intended to encourage the creation of microentreprises, in the most relevant activity sectors.

  14. Psykologi, Niveau F

    DEFF Research Database (Denmark)

    Jensen, Tommy Tranholm

    Psykologi. Niveau F retter sig primært mod grundforløbet til den pædagogiske assistent uddannelse.I bogens gennemgås de store psykologiske discipliner neuropsykologi, udviklingspsykologi og socialpsykologi. Desuden gennemgås kommunikation i et psykologisk perspektiv. Bogen indeholder en række...

  15. Tentative d'évaluation du systéme d'information marketing au niveau des banques publiques Algériennes

    OpenAIRE

    Hassaine-kazi-tani, Amel

    2014-01-01

    Le premier chapitre présente les fondements théoriques relatifs au marketing, marketing des services et notamment le marketing bancaire.dans le deuxiéme chapitre seront développées les notions de base du concept d'information et celui de systéme d'information et puis le systéme d'information marketing.le troisiéme chapitre pratique présente une étude de cas auprés des banques publiques Algériennes.

  16. ETUTDE RErROSPECTWE DE LA GESTION ET DE LA CONSOMMATION DES PRODUITS RADIOPHAR{ACEUTIQUES AU NIVEAU DU CHU— TLEMCEN

    OpenAIRE

    Sari Ali, Khadidja; ZENASNI, Rafika; Si yahiaoui, Bekhta; Sib, Vesser

    2014-01-01

    Le service de Médecine Nucléaire du CHU-Tlemcen recouvre une très grande superficie (tous l'ouest de l'Algérie) et assure au moyen de produits radiopharmaceutiques deux grands volets : une activité diagnostique et une activité thérapeutique qui peuvent être complémentaire. Le diagnostique à la scintigraphie (95% d'activité du service) est très diversifié réalisant des explorations osseuses, thyroïdiennes, parathyroïdiennes, néphro-urologiques, pulmonaires,... Le deuxième vol...

  17. On the Pathophysiology of Cutaneous Cafe-au-lait Lesions in Neurofibromatosis and the Role of Keratinocyte and/or Fibroblast-Synthesized Cytokines

    Science.gov (United States)

    2007-01-01

    au- lait Lesions in Neurofibromatosis and the Role of Keratinocyte and/or Fibroblast- Synthesized Cytokines PRINCIPAL INVESTIGATOR: Raymond E...CONTRACT NUMBER On the Pathophysiology of Cutaneous Café-au- lait Lesions in Neurofibromatosis and the Role of Keratinocyte and/or Fibroblast...putatively resulting in CALM. 15. SUBJECT TERMS Skin, café-au- lait , pigmentation, melanocytes 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF

  18. Aspects épidemiocliniques et évolutifs chez 157 cas de leishmaniose cutanée au Maroc

    Science.gov (United States)

    Hjira, Naoufal; Frikh, Rachid; Marcil, Tarik; Lamsyah, Hanane; Oumakhir, Siham; Baba, Noureddine; Boui, Mohammed

    2014-01-01

    Connue au Maroc depuis la fin du XIX siècle, la leishmaniose cutanée (LC) constitue un problème de santé publique dans notre pays. Le but de notre travail est de décrire le profil épidémioclinique et l’évolution post thérapeutique chez les patients ayant une leishmaniose cutanée dans notre contexte. Nous avons effectué une étude rétrospective, basée sur l'exploitation des dossiers de malades ayant présenté une leishmaniose cutanée confirmée entre janvier 2003 et décembre 2012. Nous avons colligés 157 cas de leishmaniose cutanée. L’âge moyen des patients était de 34.5 ans avec des extrêmes de 6 ans à 63 ans. Le sex-ratio était de 2.34 H/F. La durée d’évolution moyenne des lésions était de 3,6 mois avec des extrêmes de 2 semaines à 10 mois. Les lésions étaient uniques dans 29.5% des cas. Les lésions siégeaient sur membres dans 63%. La forme ulcèro- croûteuse touchait plus de 48%. Le Glucantime était utilisé dans 29.3% des cas, l'azote liquide était utilisé chez 111 autres. L’évolution post-thérapeutique était favorable avec disparition quasi-complète des lésions dans un délai variant de 6 à 10 semaines, au prix de cicatrices inesthétiques chez 14 patients. La leishmaniose cutanée continue à poser un vrai problème de santé publique dans notre pays. L’émergence de formes sévères et résistantes à travers le monde doit inciter à multiplier et renforcer les mesures prophylactiques. PMID:25309671

  19. A girl with cutaneous hyperpigmentation, café au lait spots and ring chromosome 15 without significant deletion.

    Science.gov (United States)

    Morava, E; Bartsch, O; Czako, M; Frensel, A; Kárteszi, J; Kosztolányi, G Y

    2003-01-01

    Ring chromosome 15 [r(15)] syndrome is characterised by specific facial features, café au lait spots, failure to thrive, mental retardation and typically with a terminal deletion of the long arm of chromosome 15. We report a 2.5 year old girl showing normal growth and development, large hyperpigmented skin changes showing hypopigmentated areas inside, multiple café au lait spots and premature graying-like hypopigmentation of scalp hair. She had a karyotype of r(15) in peripheral lymphocytes and fibroblasts. By FISH analysis the breakpoint was located distal to locus D15S936 (15q26.3) and within 300 kb of the end of the chromosome, indicating no deletion of functional genes on 15q. Hyperpigmentation and café au lait spots are rare signs in ring chromosome syndromes, but with r(15) syndrome, café au lait spots have been described in about 30% of patients and have been considered to result from the deletion of gene(s) on distal 15q. Based on the frequent observation of patchy hyperpigmentation with the r(15) syndrome, absent hyperpigmentation in cases of distal 15q deletion without a ring chromosome, and the telomeric breakpoint location in our patient indicating no significant deletion, we propose that the cutaneous hyperpigmentation and café au lait spots in our proband represent effects of the r(15) chromosome but are not caused by the deletion of specific gene(s) on distal 15q. Patchy skin hypopigmentation is a well known nonspecific sign in cytogenetic mosaicism which is commonly seen in ring syndrome.

  20. Métastases cutanées vues au laboratoire d'anatomie pathologique à Lomé, Togo entre 2005 et 2014

    Science.gov (United States)

    Darre, Tchin; Saka, Bayaki; Landoh, Dadja Essoya; Mouhari-Toure, Abas; Amegbor, Koffi; Pitché, Palokinam; Napo-Koura, Gado

    2015-01-01

    Introduction L'objectif de cette étude était de documenter le profil épidémiologique et histologique des métastases cutanées vues au laboratoire d'anatomie pathologique (LAP) de Lomé. Méthodes Il s'agissait d'une étude descriptive et transversale portant sur des cas de métastases cutanées observées au LAP du CHU Sylvanus Olympio entre 2005 et 2014. Résultats Au cours de cette période d’étude, nous avons recensé 32 cas de métastases cutanées représentant 3,2% (1005 cas) de l'ensemble des cas de métastases enregistrées au LAP. L’âge moyen des patients atteints de ces métastases cutanées était de 42,6 ans et le sex-ratio (F/H) de 2,2. Sur le plan macroscopique, ces métastases étaient nodulaires dans 15 cas, bourgeonnantes dans 12 cas, ulcéré dans 3 cas et ulcéro-bourgeonnant dans 2 cas. Les types histologiques étaient représentés par les adénocarcinomes (19 cas, 59,4%), les carcinomes épidermoïdes (8 cas, 25%), la maladie de Paget (3 cas, 9,4%), le carcinome à petites cellules du type neuroendocrine (un cas, 3,1%) et le mélanome (un cas, 3,1%). Selon le degré de différenciation, les métastases cutanées étaient bien différenciées dans 14 cas (56%). Les principales localisations de ces métastases cutanées étaient le thorax (11 cas, 34,4%) suivi de l'abdomen (10 cas, 31,3%). Les cancers primitifs étaient surtout d'origine mammaire (14 cas, 43,7%). Conclusion Cette étude montre que les métastases cutanées sont relativement rares et les tumeurs malignes d'origine mammaire sont les tumeurs primitives prédominantes. Avec un pourcentage élevé des formes peu différenciées et celles indifférenciées, l'amélioration du plateau technique du LAP (immunohistochimie) permettra d'accroitre ses capacités diagnostiques. PMID:27047627

  1. La tuberculose cutanée: observation de six cas confirmés au CHU Souro SANOU (CHUSS) de Bobo-Dioulasso (Burkina Faso)

    Science.gov (United States)

    Andonaba, Jean Baptiste; Barro-Traoré, Fatou; Yaméogo, Téné; Diallo, Boukary; Korsaga-Somé, Nina; Traoré, Adama

    2013-01-01

    La localisation cutanée de la maladie tuberculeuse demeure une forme rare et représente seulement 2,1% des localisations. L'objet de cette étude est de rapporter le profil épidémiologique, anatomoclinique et évolutif des cas de tuberculose ganglio-cutanée diagnostiqués dans un CHU au Burkina Faso. La fréquence de la tuberculose cutanée est très faible au CHUSS. Six cas ont été diagnostiqués entre 2004 et 2010, soit une fréquence de un cas par an. La durée d’évolution des cas allait de deux jusqu’à dix ans avant leur diagnostic. Les lésions observées étaient: trois scrofulodermes, trois gommes, une tuberculose testiculaire associée à un mal de Pott, un cas de polyadénopathies et des cicatrices atropho-rétractiles dans la plupart des cas. Sur le plan anatomopathologique, des granulomes tuberculoïdes ont été mis en évidence dans tous les cas avec une forte réaction tuberculinique à l'IDR. Sous antituberculeux pendant six mois, l’évolution a été bonne dans tous les cas mais au prix de séquelles cutanées cicatricielles inesthétiques. Son ampleur reste peut-être encore méconnue. Le renforcement du plateau technique du CHU et une bonne collaboration interdisciplinaire contribuerait à un meilleur diagnostic et prise en charge de cette affection. PMID:24648863

  2. Les freins à la diversification des productions d’oléo-protéagineux et de céréales au niveau des entreprises de collecte, stockage et mise en marché

    Directory of Open Access Journals (Sweden)

    Fleurat-Lessard Francis

    2013-07-01

    Full Text Available Les entreprises de collecte-stockage (ECS des grains et graines sont au carrefour entre les producteurs agricoles et l’approvisionnement des entreprises de transformation ou des exportateurs. L’ECS reçoit des matières premières de qualité fluctuante avec lesquelles elle doit satisfaire des clients exigeant des lots de qualité spécifique et stable durant toute l’année. Pour optimiser la qualité des lots mis sur le marché, les responsables d’ECS réalisent des assemblages en fonction des cahiers des charges des différents utilisateurs partenaires. Ce travail d’assemblage et la traçabilité associée à cette différentiation qualitative sont directement dépendants de la stratégie commerciale de l’ECS. En France, ces stratégies peuvent être classées en quatre groupes : (a la production en masse traitant de gros volumes de qualité minimale « standard » pour des marchés de l’alimentation animale et de l’export; (b La fourniture de lots de produits de gamme destinés au marché national à spécifications précises et segmentées; (c Le modèle marchand alimentant en circuit direct les silos portuaires pour le commerce international et les marchés à terme; (d les productions sous contrat à valeur ajoutée par des spécifications nutritionnelles ou technologiques particulières avec un circuit court du producteur à l’utilisateur final. La diversification des productions et/ou des qualités des produits et la traçabilité qui leur est intimement associée n’est envisageable que pour les modèles économiques des produits de gamme et des productions sous contrat. Toutefois, la valorisation qui peut découler d’une discrimination plus poussée des productions ou des classes de qualité n’est pas évidente car elle ne peut se réaliser qu’avec une augmentation des coûts liés à un besoin croissant de traçabilité ou à l’aménagement de circuits de manutention et de stockage spécifiques permettant d

  3. Psychodiagnostic de Rorschach et niveau d'instruction

    Directory of Open Access Journals (Sweden)

    M. Schachter

    Full Text Available Nous avons étudié comparativement, les protocoles rorschachiens de 50 intellectuels universitaires et de 50 sujets possédant au maximum l'instruction primaire obligatoire (nombreux sont ceux qui ne possédaient pas ce niveau scolaire dans le but de mettre en évidence le rôle joué par le facteur "culture scolaire" dans la configuration de ce test. Les résultats obtenus montrent que ce rôle est jndiscutable et qu'il porte, pratiquement parlant, sur la plupart, pour ne pas dire sur la totalité, des facteurs du test. Nous croyons avoir ainsi apporté une confirmation statistique, à ce sujet dont l'importance pratique ne peut pas échapper aux chercheurs qui pratiquem le psychodiagnostic de Rorschach. En effet, dans la discussion de tout protocole rorschachien, on ne doit jamais oublier de tenir compte du rôle joué par le niveau scolaire. Il est de la plus haute utilité de procéder, à l'avenir, à l'étude psychodiagnostique des frères et soeurs d'un sujet qui, seul, fait des études universitaires, afin d'apporter - s'il le faut - la preuve définitive, du rôle joué par l'instruction scolaire, dans la structure du psychogramme.

  4. Obésité abdominale et autres biomarqueurs de risque cardiométabolique: influence du niveau socioéconomique et du mode de vie dans deux populations noires apparentées, Cotonou (Bénin) et Port-au-Prince (Haïti)

    Science.gov (United States)

    Mabchour, Asma EL; Delisle, Hélène; Vilgrain, Colette; Larco, Phillipe; Sodjinou, Roger

    2016-01-01

    Introduction L’augmentation du risque cardio-métabolique (RCM) dans les pays à faible et à moyen revenu résulte pour large part d’une transition nutritionnelle rapide. Cette étude est réalisée dans deux groupes de population apparentés mais vivant dans des environnements différents. Elle vise à cerner la relation entre le mode de vie et les biomarqueurs de RCM, ainsi qu’entre l’obésité abdominale (OA) et les autres biomarqueurs. Méthodes L’étude porte sur 200 Béninois de Cotonou et 252 Haïtiens de Port-au-Prince (PAP) âgés de 25 à 60 ans et apparemment en bonne santé. L’OA est définie spécifiquement par un tour de taille (TT) ≥ 88cm (hommes) et ≥ 95cm (femmes). Les autres biomarqueurs les plus fréquents sont considérés: un ratio cholestérol total/HDL-cholestérol élevé, une tension artérielle élevée et la résistance à l’insuline d’après HOMA (Homeostasis Model Assessement). Le niveau socio-économique (NSE), l’alimentation, la consommation d’alcool et de tabac sont documentés par questionnaire. Deux schémas alimentaires ressortent de l’analyse typologique, l’un traditionnel et l’autre « transitionnel », avec une fréquence accrue d’aliments occidentaux. Résultats Le NSE, la consommation d’alcool et le tabagisme sont associés au RCM, mais non le schéma alimentaire. L’OA est associée aux autres biomarqueurs de RCM, sans effet marqué du NSE et des variables du mode de vie. Conclusion Les valeurs-seuilsspécifiques de TT se confirment. Aussi, le NSE et le mode de vie influencent le RCM mais non la relation entre l’OA et les autres biomarqueurs de RCM. PMID:28154661

  5. Les indicateurs de developpement humain au niveau infranational ...

    African Journals Online (AJOL)

    Ainsi on peut constituer un indicateur de richesse à partir des conditions de logements et de l'équipement des ménages. Pour assurer une certaine objectivité à notre travail nous avons fait le choix d'une technique automatique en l'occurrence la classification ascendante hiérarchique sans introduire de critère de contiguïté.

  6. 5 les indicateurs de developpement humain au niveau infranational

    African Journals Online (AJOL)

    pement qui satisfasse les deux approches. Mots Clés : Développement humain, Régions, Algérie, Indicateurs,. Classification automatique. Code JEL: C19, C43, C82, I30, O15, O18, R58. Le calcul des indicateurs de développement humain tels que préconisés par le programme des nations unis pour le développement.

  7. Des podcasts pour l’apprentissage au niveau universitaire

    OpenAIRE

    De Lièvre, Bruno; Temperman, Gaëtan; Dujardin, Elisabeth

    2010-01-01

    International audience; Today, podcasting is an easy means of diffusing information via the Internet to mobile devices (iPod, walkman, mobile phone,...). Our research analyzes the effect of integrating podcasting in a distance training mechanism. Numerous initiatives to develop pedagogical material for higher education are currently under way (Dale et al., 2009). To successfully design and integrate these tools in a training perspective, it is necessary to carefully think out the pedagogical ...

  8. Médecine & sport de haut niveau

    OpenAIRE

    Kaux, Jean-François

    2014-01-01

    L’engouement pour les activités sportives demeure croissant auprès du grand public grâce à toute une série d’activités sportives novatrices (Zumba, Kaerobic, etc…) et de programmes de remise en forme (« Je cours pour ma forme », etc…), bénéfiques pour la santé. Cependant, les sportifs de haut niveau, professionnels ou non, valides ou handicapés, représentant l’excellence sportive, reconnus par le code et la charte du sport de haut niveau, ne représentent qu’une infime partie de la totalité...

  9. Contribution to the study of the {sup 31}P, {sup 1}H spin spin coupling constant N. M. R. in three co-ordinated phosphorus compounds. Influence of the bond orientation and of the nature of the substituent around the phosphorus atom; Contribution a l'etude des constantes de couplage {sup 31}P, {sup 1}H en R.M.N. dans les composes organo-phosphores tricoordines. Influence des facteurs geometriques et de la nature des substituants au niveau du phosphore

    Energy Technology Data Exchange (ETDEWEB)

    Robert, J.B. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1969-07-01

    In order to investigate the influence of the configuration at the phosphorus atom and the influence of the substituents attached to the phosphorus atom on the J{sub PH} spin spin coupling constant, we have performed the NMR spectrum analysis of some three coordinated organo-phosphorus compounds. The studied coupling constants are {sup 3}J{sub PH} through P-O-C-H and P-C-C-H fragments and {sup 2}J{sub PH} through P-C-H fragment. The results clearly show that on the NMR time scale, in all the studied compounds (1,3,2-dioxaphospholanes, 1,3,2-dioxaphosphorinanes, 3-phospha-cyclopentene and 4-phosphorinanone) there is no inversion of the bonds around phosphorous. This conclusion held also for secondary phosphines. For a given geometry of the bonds joining the P and H atoms, and a given disposition of the bonds around the phosphorus atom, there is only a little influence of the nature of the substituents on the J{sub PH} spin coupling constants. The geometrical dependence of the {sup 3}J{sub PH} cannot be explained by a 'Karplus law'. There is an influence of the bond disposition around phosphorus. In the case of the {sup 2}J{sub P-C-H}, one can plot a curve {sup 2}J{sub P-C-H} = f({alpha}) (0{<=} {alpha} {<=} 180), {alpha} denote the dihedral angle of the two plane defined the first one by the P, C and H atoms, and the second one by the P-C bond together with the three-fold axis of the bond around phosphorus assuming a regular pyramidal arrangement. The function {sup 2}J{sub P-C-H} = f({alpha}) has two maxima, one for {alpha} = 0 degrees and the other for {alpha} = 180 degrees, and also a minimum for {alpha} = 110 degrees. (author) [French] Ce travail consiste en l'analyse par resonance magnetique nucleaire des constantes de couplage phosphore-proton dans des derives organo-phosphores tricoordines dans un double but: examen de la stabilite des liaisons au niveau du phosphore et etude de l'influence de la disposition des liaisons et de la nature de

  10. Mise au point

    African Journals Online (AJOL)

    7 mai 2012 ... Le carcinome folliculaire est la deuxième tumeur maligne la plus fréquente de la thyroïde et l'invasion hématologique est le moyen de propagation le plus courant de ses métastases. Les localisations secondaires à ces cancers siègent principalement au niveau des poumons, suivi par les localisations.

  11. Mise au point

    African Journals Online (AJOL)

    7 mai 2012 ... EPIdEMIOlOgIE ET ETIOPAThOgENIE. Les angiodysplasies osseuses des maxillaires sont rares. Les premiers cas rapportés sont ceux de Berard qui a décrit en 1842 une localisation au niveau du maxillaire supérieur et de Stanley qui a rapporté en 1849 une loca- lisation mandibulaire. une prédisposition ...

  12. Evaluation du niveau d'activité physique dans un service Marocain d ...

    African Journals Online (AJOL)

    Le but de notre travail est d'analyser le niveau d'activité physique chez nos patients hémodialysé chronique. Méthodes: Nous avons réalisé une étude transversale au centre d'hémodialyse de l'hôpital Al Farabi d'Oujda. Nous avons évalué l'activité physique de nos patients à l'aide du Questionnaire de Baecke traduit en ...

  13. L'influence du niveau socio-economique sur la mortalite perinatale ...

    African Journals Online (AJOL)

    Au plan de l'emploi, 55,5% des mères (212 cas) exerçaient une profession à faible revenu, 43,2% (165 cas) n'avaient pas de profession rémunératrice. La proportion des analphabètes était la plus élevée (144 cas soit 37,7%). Plus de la moitié des conjoints avaient un revenu faible (216 cas soit 56,5 %). Le niveau ...

  14. Hausse du niveau des océans et perte de terres dans le delta du Nil ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    9 juin 2016 ... Au moyen de systèmes d'information géographique (SIG), des chercheurs subventionnés par le CRDI ont déterminé les zones littorales du delta du Nil qui pourraient être touchées par la hausse du niveau des océans. Il pourrait en résulter d'importantes pertes de terres d'ici 2100. Selon les plus récentes ...

  15. Two cases of subdural hematoma with niveau formation on CT. A study of the cause of niveau formation

    Energy Technology Data Exchange (ETDEWEB)

    Shimizu, Satoshi; Fukuda, Atsuhiro; Sato, Masaharu; Kohama, Akitsugu (Kawasaki Medical School, Kurashiki, Okayama (Japan))

    1984-04-01

    The authors report a case of a bilateral chronic subdural hematoma with niveau formation and another rare case of an acute subdural hematoma with niveau formation on plain CT. The different mechanisms of the niveau formation in these cases are speculated about. The first case was a 75-year-old male who showed a drowsy state, urinary incontinence, and muscle weakness of the bilateral lower limbs. No definite history of head trauma could be found. A plain CT scan showed a bilateral-crescent type fluid collection with niveau formation, consisting of a low-density area in the upper part and a high-density area in the lower part. An operation showed bilateral, moderately encapsulated subdural hematomas; they were evacuated. The second case was a 61-year-old male with head trauma due to a fall from a ladder. On admission, neurological examination revealed a decerebrate posture, a deep coma, and anisocoria. A plain CT scan twenty hours after the onset showed a crescent-type fluid collection with niveau formation in the left fronto-parietal region. The operation showed an acute subdural hematoma containing xanthochromic fluid and coagulated blood. No capsule of hematoma could be seen. The incidence of niveau formation in chronic subdural hematomas is not low (5 - 20%); such niveau formation is thought to be caused by rebleeding into the hematoma and the spending of considerable time in the supine position. On the other hand, no case of an acute subdural hematoma with niveau formation has previously been reported. With regard to this mechanism of niveau formation, we speculate that the hematoma is mixed with cerebrospinal fluid from the arachnoidal tear caused by the head trauma; also, a considerable time in the supine position is necessary.

  16. Part of the oxidative stress in the development of radio-induced cell effects at cutaneous level: application to accidental localised irradiations; Role du stress oxydatif dans le developpement des effets cellulaires radio-induits au niveau cutane: application aux irradiations localisees accidentelles

    Energy Technology Data Exchange (ETDEWEB)

    Carine, Laurent

    2005-10-15

    The objective of our study was to answer to the following questions: does the initial radio-induced oxidative stress lead to the accumulation of DNA damages in the low renewal cells (fibroblasts, endothelial cells) that could be responsible of delayed effects; does it exist delayed oxidative phenomena and era they implied in the delayed effects arising; does it exist a phenomenon of premature senescence; does it exist a premature senescence phenomenon that could lead to an accumulation of damages before the cell death; what are the action mechanisms of the association pentoxifylline/{alpha}-tocopherol. (N.C.)

  17. Cutaneous leishmaniasis

    OpenAIRE

    Ramesh V; Kumar Joginder

    2006-01-01

    ABSTRACTLeishmaniasis is considered to be zoonotic disease, caused by a protozoan parasite of the genus Leishmania, and transmitted by a bite of infected female sandfly. Primary cutaneous leishmaniasis is not common disease in Nepal, however, there were cases reported from Terai region of Nepal. The patients with cutaneous leishmaniasis present with a papule or nodule at the site of inoculation, followed by formation of crusts. Differential diagnoses of cutaneous leishmaniasis include variety...

  18. Mise au point

    African Journals Online (AJOL)

    7 mai 2012 ... acquis et des anomalies génétiques associées ont été aussi incriminés (mutation du gène Fas ou de la p53, délétion au niveau du chromosome 6q, méthylation excessive de la p73) (15,16). Le mode de révélation de ces lymphomes est peu spéci- fique et parfois banal. L'obstruction nasale représente le.

  19. Cutaneous leishmaniasis

    Directory of Open Access Journals (Sweden)

    Ram Chandra Adhikari

    2017-09-01

    Full Text Available ABSTRACTLeishmaniasis is considered to be zoonotic disease, caused by a protozoan parasite of the genus Leishmania, and transmitted by a bite of infected female sandfly. Primary cutaneous leishmaniasis is not common disease in Nepal, however, there were cases reported from Terai region of Nepal. The patients with cutaneous leishmaniasis present with a papule or nodule at the site of inoculation, followed by formation of crusts. Differential diagnoses of cutaneous leishmaniasis include variety of skin diseases, inflammatory like impetigo, eczema, or granulomatous like sarcoidosis, lupus vulgaris, to skin tumor like basal cell carcinoma & squamous cell carcinoma. There are various procedures and laboratory techniques used to diagnose leishmaniasis. Punch skin biopsy is widely used & popular technique to diagnose cutaneous leishmaniasis. Different drugs like sodium stibogluconate, sodium antimony gluconate, Amphotericin B and Miltefosine: are used for its treatment. No vaccines are available for prevention. 

  20. Utilisation de traceurs radioactifs pour l'évaluation du recrutement des leucocytes et des échanges vasculaires au niveau d'organes in~vivo. Description d'une méthode et discussion des problèmes d'interprétation sur quelques exemples

    Science.gov (United States)

    Bureau, M. F.

    1997-03-01

    An experimental method using simultaneously different γ emiter tracers was developed to evaluate inflammation in vivo. Experiments were performed on the anaesthetized guinea-pig to test pulmonary effects of inflammatory agents. Red blood cells, albumin and inflammatory cells (platelets or leucocytes) radiolabelled with 99m technetium, 131 iodine and 111 indium respectively were injected i.v. Their radioactivities were measured on a pulmonary region by external detection and on blood samples in a well type counter. From these measurements variations of the lung contents in red blood cells, extravascular albumin and non circulating leucocytes during inflammatory stimulation were evaluated. These parameters axe indexes of blood perfusion, vascular exchanges and leucocyte sequestration respectively. Fiability of the method and meaning of the parameters evaluated are discussed. Une méthode expérimentale utilisant simultanément différents traceurs γ a été développée pour évaluer l'inflammation in vivo. Des expériences ont été réalisées chez le cobaye anesthésié pour tester l'effet pulmonaire d'agents inflammatoires. Des globules rouges, de l'albumine et des cellules inflammatoires (plaquettes ou leucocytes) radiomarqués respectivement au technetium 99m, à l'iode 131 et à l'indium 111 sont injectés i.v. Leurs radioactivités sont mesurées sur une région pulmonaire par détection externe et sur des échantillons sanguins au compteur puit. À partir de ces mesures sont évaluées les variations des contenus pulmonaires en globules rouges, en albumine extravasculaire et en leucocytes non circulants lors d'une stimulation inflammatoire. Ces paramètres sont corrélés aux modifications de la perfusion, des échanges vasculaires et de la séquestration leucocytaire. La fiabilité de la méthode et la signification des paramètres évalués sont discutées.

  1. Behaviour and passage of European silver eels (Anguilla anguilla at a small hydropower plant during their downstream migration Comportement et passage de l’anguille argentée (Anguilla anguilla au niveau d’une petite centrale hydroélectrique lors de sa migration de dévalaison

    Directory of Open Access Journals (Sweden)

    De-Oliveira E.

    2010-09-01

    Full Text Available Between 2004 and 2007, 116 downstream migrant silver eels (Anguilla anguilla were monitored at a hydropower plant on the Gave de Pau river in South-West France using radio and PIT telemetry. The objectives of the study were: (i to determine the environmental conditions when eels arrived and passed the facility; (ii to determine the rate of eel escapement (passage other than via the turbines; (iii to describe the behaviour of eels faced with the intake structure and the permeability of the intake trashracks for the different sizes of eel; and (iv to determine whether surface bypasses originally designed for salmon could be effective for eels. Five types of behaviour of silver eels in the forebay and at the plant intakes were identified. The study showed the key factor influencing both eel behaviour and the route taken through the plant was variation in river discharge. Escapement rate was related to eel length and the spill flow to river flow ratio, which could be described by a logistic regression model. The surface bypasses originally designed for salmon were found to aid downstream eel migration significantly. At velocities < 0.40 m·s−1, no eels, even the largest, for which the racks are a physical barrier, were found impinged on the trashracks. De 2004 à 2007, une étude sur la migration de dévalaison de l’anguille argentée européenne (Anguilla anguilla a été menée sur la centrale hydroélectrique de Baigts sur le Gave de Pau dans le Sud-Ouest de la France. Cette étude, au cours de laquelle 116 individus ont été suivis par télémétrie PIT et radio, avait pour objectifs : (i de déterminer les conditions de milieu propices à l’arrivée sur site et au franchissement de l’aménagement; (ii de déterminer les taux d’échappement (passages par des voies autres que les turbines; (iii d’analyser le comportement des anguilles devant les ouvrages et la perméabilité des grilles de la prise d’eau en fonction de la taille

  2. Cutaneous Leishmaniasis

    Directory of Open Access Journals (Sweden)

    Mehmet Harman

    2015-12-01

    Full Text Available Leishmaniasis is used to describe a spectrum of diseases caused by the parasitic protozoa leishmania spp. and transmitted by infected female sandflies. There are three main forms of the disease; cutaneous, mucocutaneous, and visceral. According to the World Health Organization, almost 12 million people from 98 countries worldwide are currently infected with leishmaniasis, while 350 million people are at risk. It was reported that 2 million new cases are diagnosed every year, with three-fourth are cutaneous leishmaniasis (CL cases. The scientific and medical communities have learnt a lot about CL during the 20th and early 21st centuries. However, the management and control of the disease remains a difficult task. This article was focused on the most common form of the disease, cutaneous leishmaniasis, and especially its epidemiological aspects and treatment.

  3. Cutaneous Porphyrias

    DEFF Research Database (Denmark)

    Lindegaard Christiansen, Anne; Aagaard, Lise; Krag, Aleksander

    2016-01-01

    Porphyrias are rare diseases caused by altered haem synthesis leading to the accumulation of different haem intermediates. Neurovisceral attacks may occur in acute porphyrias, while photosensitivity is the presenting symptom in cutaneous porphyrias. We present here an overview of symptoms...... and a flowchart for the diagnosis of cutaneous porphyrias, with recommendations for monitoring and an update of treatment options. From the Danish Porphyria Register, we present the incidences and approximate prevalences of cutaneous porphyrias within the last 25 years. A total of 650 patients with porphyria...... cutanea tarda were identified, 73 with erythropoietic protoporphyria, 9 with variegate porphyria, 4 with hereditary coproporphyria and one with congenital erythropoietic porphyria. The total incidence of all porphyrias was ~0.52/100,000 per year....

  4. Vocabulaire illustré 350 exercices : niveau moyen

    CERN Document Server

    Watcyn-Jones, Peter

    1995-01-01

    Cet ouvrage de vocabulaire illustré est conçu dans le même esprit que le niveau débutant auquel il fait suite. Il propose un travail stimulant et amusant pour approfondir son lexique, soit 1350 mots utiles et courants, rassemblés par thèmes (la maison, les magasins, les métiers, les animaux, le bricolage...) ou par catégories grammaticales. Il comprend des exercices d'apprentissage et d'élargissement, aussi bien pour les jeunes que pour les adultes. Un livret de corrigés est également disponible.

  5. la lutte contre le SIDA au Cameroun

    African Journals Online (AJOL)

    Chantel

    plurielles'). Tsala Tsala, J.-Ph. (2001). Medicina tradicional y sistema de salud publica en Camerun. Siso/Saude. 35: 48 -57. UNICEF, ONUSIDA, OMS (2001). Suivi et évaluation (au niveau local) de la prévention intégrée de la transmission mère-enfant du VIH dans les pays à revenus faibles.(doc ined. Projet 03/2001). 156.

  6. Restauration fonctionnelle du rachis : effet du niveau initial de douleur sur les performances des sujets lombalgiques chroniques

    Science.gov (United States)

    Caby, Isabelle; Olivier, N; Mendelek, F; Kheir, R Bou; Vanvelcenaher, J; Pelayo, P

    2014-01-01

    HISTORIQUE : La lombalgie chronique est une douleur lombaire persistante d’origine multifactorielle. Le niveau de douleur initial reste faiblement utilisé pour analyser et comparer les réponses des patients lombalgiques au programme de reconditionnement. OBJECTIFS : Apprécier et évaluer les réponses des sujets lombalgiques chroniques très douloureux à une prise en charge dynamique et intensive. MÉTHODOLOGIE : 144 sujets atteints de lombalgie chronique ont été inclus dans un programme de restauration fonctionnelle du rachis de 5 semaines. Les sujets ont été classés en deux groupes de niveau de douleur: un groupe atteint de douleur sévère (n = 28) et un groupe atteint de douleur légère à modérée (n = 106). L’ensemble des sujets ont bénéficié d’une prise en charge identique comprenant principalement de la kinésithérapie, de l’ergothérapie, du reconditionnement musculaire et cardio-vasculaire ainsi qu’un suivi psychologique. Les paramètres physiques (flexibilité, force musculaire) et psychologiques (qualité de vie) ont été mesurés avant (T0) et après le programme (T5sem). RÉSULTATS : L’ensemble des performances physiques et fonctionnelles des sujets très douloureux sont moins bonnes et le retentissement de la lombalgie sur la qualité de vie, pour ces mêmes sujets, est majoré à T0. Toutes les différences significatives constatées à T0 entre les deux groupes s’effacent à T5sem. CONCLUSIONS : Les sujets lombalgiques chroniques très douloureux répondent favorablement au programme dynamique et intensif. L’intensité douloureuse de la lombalgie n’aurait pas d’effet sur les réponses au programme. La restauration fonctionnelle du rachis apporterait aux sujets la possibilité de mieux gérer leur douleur quel que soit son niveau. PMID:25299476

  7. Communication progressive du français avec 320 exercices : niveau débutant : corrigés

    CERN Document Server

    Miquel, Claire

    2013-01-01

    Ce qui fait le succès de cet ouvrage de communication: Une organisation claire: la leçon sur la page de gauche; les exercices et les activités communicatives sur la page de droite 40 fiches présentant les points généralement abordés au niveau A1 du Cadre européen commun de référence pour les langues Un apprentissage progressif: il suit la progression naturelle des méthodes de français Un usage souple: pour la classe ou en auto-apprentissage Une préparation adaptée aux certifications: un entrainement efficace pour mieux réussir aux examens A découvrir dans cette deuxième édition revue et augmentée: Un CD audio avec 69 documents sonores Un test d'évaluation avec ses corrigés Des illustrations pédagogiques acutelles et colorées 50 nouveaux exercices. Communication Progressive du français niveau débutant, 2ème édition (ISBN 978-209-038132-0).

  8. Communication progressive du français avec 320 exercices : niveau débutant

    CERN Document Server

    Miquel, Claire

    2013-01-01

    Ce qui fait le succès de cete ouvrage de communication: Une organisation claire: la leçon sur la page de gauche; les exercices et les activités communicatives sur la page de droite 40 fiches présentant les points généralement abordés au niveau A1 du Cadre européen commun de référence pour les langues Un apprentissage progressif: il suit la progression naturelle des méthodes de français Un usage souple: pour la classe ou en auto-apprentissage Une préparation adaptée aux certifications: un entrainement efficace pour mieux réussir aux examens A découvrir dans cette deuxième édition revue et augmentée: Un CD audio avec 69 documents sonores Un test d'évaluation avec ses corrigés Des illustrations pédagogiques acutelles et colorées 50 nouveaux exercices. Un livret de corrigés est proposé à part (ISBN 978-209-038133-7).

  9. Vocabulaire progressif du français avec 250 exercices : niveau débutant : corrigés

    CERN Document Server

    Miquel, Claire

    2002-01-01

    Pour travailler en autonomie, un complément indispensable au Vocabulaire progressif du français niveau débutant : les corrigés de toutes les activités.Les corrigés sont organisés sur le modèle du livre par chapitres thématiques correspondant à divers domaines de la réalité quotidienne et contemporaine. Le lexique est présenté de façon thématique. Chaque chapitre est constitué de plusieurs séquences assurant un enrichissement progressif. Ce manuel aborde un vocabulaire vivant qui correspond à la réalité des français d'aujourd'hui. Il constitue une véritable initiation aux codes culturels.

  10. Unusual Cutaneous Manifestation of Tuberous Sclerosis

    Directory of Open Access Journals (Sweden)

    K C Shah

    1980-01-01

    Full Text Available Cutaneous manifestations are found in 60 to 70% cases of tuberous sclerosis and consist of adenoma sebaceum, periungual fibromatas, cafe au lait spots, shagreen patches and white macules. Our patient showed unusual skin manifestations like spotty pigmentation on the chest, back and abdomen and hyperkeratosis palmaris et plantaris.

  11. Les mesures de confiance au niveau des mots et leurs applications pour la traduction automatique statistique

    OpenAIRE

    Luong, Ngoc Quang

    2014-01-01

    Machine Translation (MT) systems, which generate automatically the translation of a target language for each source sentence, have achieved impressive gains during the recent decades and are now becoming the effective language assistances for the entire community in a globalized world. Nonetheless, due to various factors, MT quality is still not perfect in general, and the end users therefore expect to know how much should they trust a specific translation. Building a method that is capable o...

  12. Retour au niveau II Vers l'autonomie de l'apprentissage (Towards Autonomy in Learning).

    Science.gov (United States)

    Bourdet, Jean-Francois

    1992-01-01

    Treats the suitability of Level 2, a program designed to teach French as a Foreign Language. The goal of the program is learner autonomy. The use of authentic materials and an emphasis on culture are recommended. (AG)

  13. 410 Contamination métallique de Gambusia holbrooki au niveau du ...

    African Journals Online (AJOL)

    youness

    du lac Fouarat et de l'estuaire Sebou dans la région du. Gharb (Maroc). Bachir EL BOUHALI1, Laila BENNASSER1*, Issad NASRI2,. Vincent GLOAGUEN3 et Aziza ... L'irrigation courante des parcelles agricoles avec les eaux contaminées du lac comporte aussi des risques qu'il convient d'éviter et surtout d'évaluer.

  14. Mise au point d'un test in vitro de comportement au sel de quatre ...

    African Journals Online (AJOL)

    agrumes, en termes de résistance à la salinité in vitro au niveau des cals et des cellules cultivées parallèlement sur milieu liquide et solide. Méthodologie et résultat : À cet égard, des cals de quatre génotypes d'agrumes : mandarinier Cléopâtre ...

  15. Niveau de vie, croissance et énergie Standard of Living - Growth and Energy

    Directory of Open Access Journals (Sweden)

    Offant P.

    2006-11-01

    Full Text Available Cet article rassemble les principaux résultats d'une Action Thématique Programmée consacrée aux « problèmes socio-économiques de l'énergie » et confiée par le Centre National de la Recherche Scientifique (CNRS au Département Économie de l'Institut Français du Pétrole (IFP. Les problèmes posés par la mesure du niveau de vie et par ses liaisons avec la consommation d'énergie sont l'objet d'une première analyse. Elle permet de dégager les grandes orientations des possibilités de réduction de la consommation d'énergie sans régression du niveau de vie, au sens des économies des pays d'Europe occidentale. Sur ces bases, deux scénarios contrastés de demande d'énergie finale à long terme sont quantifiés dans le cas de la France Le scénario de moindre consommation d'énergie intègre une restructuration industrielle déterminée par optimisation d'un modèle linéaire issu du tableau entrée-sorties de la Comptabilité nationale. Les deux projections de demande d'énergie sont appliquées à un modèle linéaire dynamique de production. Ce modèle fournit les résultats nécessaires à une analyse détaillée de l'évolution structurelle du secteur énergétique et au calcul de bilans d'énergie primaire prévisionnels cohérents. This article gathers the main results of an « Action Thématique programmée » (research project on a Socio-Economic Energy Problems » which Centre National de la Recherche Scientifique (CNRS assigned to the Institut Français du Pétrole (IFP Economics Department. The problems raised by measuring the standard of living and by its links with energy consumption are the subject of a preliminary analysis which brings out the major guidelines concerning possibilities of reducing energy consumption without cousing any regression in the standard of living in the economies of Western European countries. On th~ese bases, two contrasting scénarios for the final ta long-term energy demand were worked out

  16. Exercices de vocabulaire en contexte niveau débutant

    CERN Document Server

    Eluerd, Roland

    2005-01-01

    Un entraînement à l'acquisition du lexique en contexte. Avec de nombreuses illustrations. Cet ouvrage s'adresse à des adolescents ou adultes débutants pour un travail en classe ou en autonomie. Un livre très simple à utiliser: 1 leçon = 1 thème = 1 double page - Un sommaire thématique en 50 leçons réparties selon 10 grands thèmes. Les 50 leçons suivent une progression méthodique de découverte et de pratique du vocabulaire conçue pour des lecteurs débutants (niveau A1 du cadre européen commun de référence). - Pour chaque leçon: > une présentation illustrée du vocabulaire, en contexte, en page de gauche; > des activités très simples (autonomie) en parge de droite. - Un index est proposé en fin d'ouvrage.

  17. Evaluation du niveau d'activité physique dans un service Marocain d'hémodialyse chronique

    Science.gov (United States)

    Karimi, Ilham; Benabdellah, Nawal; Bentata, Yassamine; Yacoubi, Hicham; Haddiya, Intissar

    2013-01-01

    Introduction L'activité physique est souvent réduite chez le patient hémodialysé chronique. Plusieurs études ont montré l'intérêt du maintien ou de la reprise d'une activité physique sur l’état de santé des patients. Le but de notre travail est d'analyser le niveau d'activité physique chez nos patients hémodialysé chronique. Méthodes Nous avons réalisé une étude transversale au centre d'hémodialyse de l'hôpital Al Farabi d'Oujda. Nous avons évalué l'activité physique de nos patients à l'aide du Questionnaire de Baecke traduit en dialectal Marocain et adapté au contexte socioculturel Marocain. Nous avons relevé les paramètres démographiques et clinico-biologiques ainsi que le niveau d'activité physique. L'analyse statistique est réalisée par le logiciel SPSS 11.5. Résultats Notre étude a inclus 83 patients. L’âge moyen était de 47,3±13,2 ans, avec une prédominance masculine. 15,6% déclarent n'avoir aucune activité physique. 68% des patients rapportent des difficultés à effectuer des efforts physiques importants (courir, soulever un objet lourd). 16,4% des patients déclarent avoir une activité physique et sportive régulière (marche, foot-ball etc..). La diminution de l'activité physique est corrélée de façon significative à l’âge avancée, l'indice de masse corporelle bas, l'ancienneté en hémodialyse et les affections cardio-vasculaires. Conclusion Un programme d'activité physique adapté à notre population d'hémodialysés et élaboré en concertation pluridisciplinaire (cardiologues, orthopédistes, rhumatologues, kinésithérapeutes) paraît intéressant dans le cadre d'une prise en charge globale du patient hémodialysé chronique. PMID:24198881

  18. Etude des etats electroniques en champ magnetique dans le niveau de Landau N=0 de la tricouche ABC de graphene

    Science.gov (United States)

    Rondeau, Maxime

    Dans cet ouvrage nous etudions les phases du gaz d'electrons bidimensionnel dans la tricouche de graphene en empilement ABC. En partant du modele des liaisons fortes et en faisant l'approximation du continuum autour des vallees K +, K-, nous obtenons un modele effectif a deux bandes qui permet de decrire la physique de basse energie des electrons en champ magnetique dans cette structure. Ce modele contient trois orbitales degenerees dans le niveau de Landau N = O. Ce dernier est donc 12N φ, fois degeneres en incluant les degres de liberte de spin et de vallee. En ajoutant l'interaction de Coulomb au systeme et en considerant seulement les remplissages v = -5, -4, -4, 5 afin d'avoir un systeme a trois niveaux, nous etudions le diagramme de phase du gaz d'electrons en fonction d'un biais electrique entre les couches externes. Nous trouvons une phase d'onde de densite de charge bidimensionnelle (ODC2D) comme etat fondamental du systeme. Cette ODC2D se nomme cristal dans ce memoire et nous derivons ses proprietes de transports et ses modes collectifs. Nous discutons egalement du caractere topologique de ce cristal. Notre etude englobe aussi les phases liquides avec ou sans coherence orbitale. Nous concluons notre memoire par l'etude de quelques signatures experimentales des phases du gaz d'electrons dans la tricouche.

  19. Niveau et coût du protectionnisme européen

    OpenAIRE

    Messerlin, Patrick

    2010-01-01

    L'article commence par estimer le niveau et les coûts de la protection en Europe. Le niveau moyen de protection (droits de douane et principales barrières non-tarifaires) est de 12 % environ (contre 14 % jusqu'en 1997) avec des pics élevés pour les produits agricoles et certains biens industriels. Le coût de cette protection pour les consommateurs européens est estime à 7 % du PNB européen, soit l'équivalent du PNB espagnol. L'article présente ensuite les principaux aspects de la politique co...

  20. Chemotherapy of Cutaneous Leishmaniasis

    Science.gov (United States)

    2012-10-01

    1 Award Number: W81XWH-10-2-0196 TITLE: CHEMOTHERAPY OF CUTANEOUS LEISHMANIASIS PRINCIPAL INVESTIGATOR: DR. ARBA AGER CONTRACTING...DATE October 2012 2. REPORT TYPE Final 3. DATES COVERED 01Sep2010–31 Dec 2012 4. TITLE AND SUBTITLE CHEMOTHERAPY OF CUTANEOUS LEISHMANIASIS 5a...was used for tabulation of data and statistically analyzing the results. 15. SUBJECT TERMS- Leishmania major, Cutaneous Leishmaniasis , antileishmanial

  1. Travelers' Health: Leishmaniasis, Cutaneous

    Science.gov (United States)

    ... Legionnaires’ Disease & Pontiac Fever) Chapter 3 - Leishmaniasis, Visceral Leishmaniasis, Cutaneous Barbara L. Herwaldt, Alan J. Magill Leishmaniasis is a parasitic disease found in parts of ...

  2. Grammaire pour adolescents 250 exercices : niveau débutant

    CERN Document Server

    Bié, Nathalie

    2005-01-01

    Ce nouveau livre d'exercices de grammaire, de la collection Le Nouvel Entraînez-vous, s'adresse à un public d'adolescents débutants et faux débutants en français langue étrangère. L'ouvrage propose 250 exercices de compréhension et de mémorisation à travers des activités de déduction et de réemploi des notions grammaticales étudiées. Le contenu des exercices est organisé autour de contextes langagiers proches de la réalité des adolescents afin de placer la communication au cœur de l'apprentissage. L'introduction des contenus grammaticaux suit la même progression que les méthodes usuelles. Chaque chapitre débute par une séquence Rappel permettant à l'apprenant de revoir rapidement les règles grammaticales développées dans les exercices. Chaque exercice est introduit par une consigne brève et concise accompagnée d'un exemple. L'ouvrage a été conçu en tenant compte des centres d'intérêts des adolescents et propose de nombreuses illustrations intégrées aux exercices. A la fin d...

  3. Canine cutaneous leishmaniasis

    OpenAIRE

    Sasani, F.; Javanbakht, J.; Samani, R.; Shirani, D.

    2014-01-01

    Canine cutaneous leishmaniasis (CCL) is a significant veterinary problem. Infected dogs also serve as parasite reservoirs and contribute to human transmission of cutaneous leishmaniasis. Histologically, the lesions were nodular to diffuse interstitial granulomatous dermatitis with histiocytic pseudorosettes together with numerous amastigotes within macrophages and occasionally within the interstitium. Organisms were often contained within clear and intracellular vacuoles. The other inflammato...

  4. Le débat au sujet des effets du salaire minimum sur l'emploi se ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    13 déc. 2012 ... Lucas Ronconi, chercheur au Centro de Investigacion y Accion Social, en Argentine, a expliqué que pendant les années 1990, le gouvernement a maintenu le salaire minimum au même niveau et assoupli l'application, ce qui a favorisé la croissance non pas de l'emploi en général, mais de l'emploi dans ...

  5. Ecthyma mimicking cutaneous leishmaniasis

    Directory of Open Access Journals (Sweden)

    Moteb K. Alotaibi

    2015-03-01

    Full Text Available Chronic non-healing ulcerated skin lesion can be a diagnostic dilemma for the dermatologist in an area endemic with cutaneous leishmaniasis. The differential diagnosis may include a large list of cutaneous diseases ranging from infection to advanced skin cancers. Ecthyma is cutaneous infection caused by group A beta-hemolytic streptococci or Staphylococcus aureus bacteria with dermal and subcutaneous invasion. Ecthyma is a differential diagnosis for cutaneous Leishmaniasis presenting as an ulcerated lesion in endemic areas. Being in endemic area for cutaneous leishmaniasis, general physicians and some dermatologist may miss other important and common differential diagnosis, resulting in delay of proper management and increase risk of complications. Our aim in this work is to draw the attentions toward better management while dealing with ulcerated cutaneous lesions. Method: Case reporting. Result: This is a case of a 60 year-old Sudanese male patient who presented with a chronic nonhealing ulcerated lesions at his right forearm for 4 months. The patient was misdiagnosed as a case of cutaneous leishmaniasis and he was treated with anti-leishmanial therapy with no improvement. He was finally diagnosed to have staphylococcal ecthyma that successfully responded to oral antibiotic. Conclusion: Dealing with chronic ulcerated skin lesion requires a carful and detailed history taking and a good knowledge of the common and endemic diseases in the patient’s area supported by proper laboratory studies

  6. 184 Évaluation du niveau de pollution par les métaux lourds des ...

    African Journals Online (AJOL)

    Afrique Sciences

    La présente étude a pour objectif principal d'évaluer le niveau de pollution métallique des lacs Bini et Dang ... Ainsi, ces dernières années, la pollution par les métaux lourds est devenue un problème ...... [16] - FANG T. H., HWANG J. S., HSIAO S. H. and CHEN H. Y. Trace metals in seawater and copepods in the ocean.

  7. Évaluation du niveau de pollution par les métaux lourds des lacs ...

    African Journals Online (AJOL)

    La présente étude a pour objectif principal d'évaluer le niveau de pollution métallique des lacs Bini et Dang (Ngaoundéré, Cameroun) à travers l'analyse des eaux et des sédiments de surface. La concentration des métaux lourds (Ni, Cr, Fe, Pb, Cd, Zn) a été mesurée par spectrophotométrie d'absorption atomique.

  8. Perception paysanne et impact agro-pédologique du niveau de ...

    African Journals Online (AJOL)

    Les résultats ont montré un faible niveau de mécanisation générale et trois groupes d'exploitants : les grands exploitants (type E1) qui disposent de grands moyens de productions, les exploitants moyens (type E2) et les petits exploitants (type E3) ayant de faibles revenus. Aussi, une proportionnalité existe entre les facteurs ...

  9. Niveau de connaissance et composition minérale de Hydrocotyle ...

    African Journals Online (AJOL)

    Hydrocotyle bonariensis est une espèce végétale entrant dans les habitudes alimentaires et médicinales des populations en Côte d'Ivoire. Ce travail a été mené afin de déterminer le niveau de connaissance et d'utilisation de cette plante dans les ménages du district d'Abidjan ainsi que sa composition en micronutriments.

  10. Effets du tabagisme et du niveau de dépendance nicotinique sur les ...

    African Journals Online (AJOL)

    Evaluer les effets du tabagisme et de la dépendance nicotinique sur le niveau de développement des métabolismes anaérobies alactique et lactique chez des footballeurs fumeurs. Soixante trois footballeurs non-fumeurs et 63 fumeurs de première division ligue, âgés de 18 à 33 ans, ont été soumis à deux tests ...

  11. PRIMARY CUTANEOUS LEIOMYSARCOMA

    OpenAIRE

    Shubhangi Vinayak Agale; Sumit Grover; Rahul Zode; Shilpa Hande

    2011-01-01

    Primary cutaneous leiomyosarcoma of the skin is a rare soft tissue neoplasm, accounting for about 2-3% of all superficial soft tissue sarcomas. It arises between the ages of 50 and 70 years, and shows a greater predilection for the lower extremities. Clinically, it presents with solitary, well-circumscribed nodule and, microscopically, consists of fascicles of spindle-shaped cells with "cigar-shaped" nuclei. Local recurrence is known in this tumor. We document a case of primary cutaneous leio...

  12. Recurrent cutaneous leishmaniasis

    OpenAIRE

    Gomes,Ciro Martins; Damasco,Fabiana dos Santos; Morais,Orlando Oliveira de; Paula,Carmen Dea Ribeiro de; Sampaio,Raimunda Nonata Ribeiro

    2013-01-01

    We present a case of an 18-year-old male patient who, after two years of inappropriate treatment for cutaneous leishmaniasis, began to show nodules arising at the edges of the former healing scar. He was immune competent and denied any trauma. The diagnosis of recurrent cutaneous leishmaniasis was made following positive culture of aspirate samples. The patient was treated with N-methylglucamine associated with pentoxifylline for 30 days. Similar cases require special attention mainly because...

  13. Results of cycling with battery charging management; Resultats de cyclage avec gestion de charge au niveau batterie

    Energy Technology Data Exchange (ETDEWEB)

    Verniolle, J.; Fernandez, C. [European Space Research and Technology Centre, Noordwijk (Netherlands)

    1996-12-31

    In order to investigate the charging mode of an in-series assembly of lithium-carbon battery cells, a test has been performed on 5 commercial cells (18650) of 0.95 Ah nominal capacity. Results show that it is possible to cycle the cells at 80% of their output capacities during more than 2000 cycles. The management of the battery consists in maintaining a constant battery voltage as soon as a cell reaches its limit voltage during constant current charging. The initial dispersion of cells has been maintained practically constant during the cycling and the charge state of all cells has decreased progressively. (J.S.)

  14. profil epidemiologique de la bronchiolite aigue chez le nouveau ne et le nourisson au niveau de l EHS de tlemcen

    OpenAIRE

    mahiaoui, amal; mecifi, nassima

    2011-01-01

    • la bronchiolite algue est une infection respiratoire algue très fréquente chez le nourrisson et est devenu un problème de santé publique. • D'après ces études on conclut que la bronchiolite est une affection à fréquence élevé, prédominante chez le sexe masculin, les antécédents personnels et familiaux influencent sur la genèse de la bronchiolite, la plus part est d'origine virale et l'antibiothérapie ne doit pas être utilisé qu'après la non amélioration des cas ou une suri...

  15. Transmission et plasticité activité-dépendante au niveau des synapses cortico-striatales

    OpenAIRE

    Fino, Elodie

    2007-01-01

    Le striatum a pour rôle de sélectionner et d'intégrer les informations provenant du cortex et ainsi construire et transmettre une réponse adaptée aux stimuli environnementaux. Nous avons caractérisé les propriétés électrophysiologiques des différents neurones du striatum (neurones de sortie, NETM, et interneurones) dans des conditions normales, et lors d'une déplétion de dopamine striatale. Grâce à un modèle de tranche de cerveau de rat dans laquelle les afférences cortico-striatales sont con...

  16. Measurements of sub photon cavity fields by atom interferometry; Mesures de champs au niveau du photon par interferometrie atomique

    Energy Technology Data Exchange (ETDEWEB)

    Nussenzveig, P

    1994-07-15

    Two neighbouring levels of a Rydberg atom coupled to a high quality-factor microwave cavity are an excellent tool for the study of matter-wave interactions at the most basic level. The system is so simple (a two-level atom coupled to a single mode of the field) that most phenomena can be described analytically. In this work we study dispersive effects of the non-resonant atom-cavity interaction. We have measured the linear dependence of the atomic energy level-shifts on the average photon number in the cavity. Light shifts induced by an average microwave field intensity weaker than a single photon have been observed. It has also been possible to measure the residual shift of one of the two levels of the atomic transition in the absence of an injected field: a Lamb shift due to a single mode of the field. A sensitive measurement of these energy shifts is performed by an interferometric method: the Ramsey separated oscillatory fields technique. Future experiments, in a situation of very weak field relaxation, are proposed. The quantum behavior of the field will then be dominant and it shall be possible to perform a Quantum Non-Demolition measurement of the photon number: since the interaction is non-resonant, the atoms can neither absorb nor emit photons in the cavity. The performed experiments demonstrate the sensitivity of the apparatus and set the stage for future non-demolition measurements and for the study of 'mesoscopic' Schroedinger cat states of the field, on the boundary between classical and quantum worlds. (author)

  17. L'enseignement au niveau avance: Problemes et essais (Instruction on the Advanced Level: Problems and Experiments).

    Science.gov (United States)

    Racle, G.

    The determination of Objectives conditions the choice of materials, methods, and evaluation of results in all stages of foreign language learning. The first level is a necessary foundation, but by itself is insufficient for the study of literature or for communication purposes in a new linguistic milieu. The fundamental notion of language styles…

  18. Schwa au niveau avance du francais langue seconde (Schwa at the Advanced Level of French as a Second Language).

    Science.gov (United States)

    Thomas, Alain

    2001-01-01

    Discusses part of a large-scale survey on the oral performance of advanced French-as-a-second-language students, as represented by recorded speech. Although schwa rarely leads to semantic confusions, its analysis in word-median or monosyllabic contexts shows interesting phonostylistic variations. (Author/VWL)

  19. Les facteurs d'efficacite des ecoles secondaires au Cameroun ...

    African Journals Online (AJOL)

    Les résultats démontrent que le niveau moyen d'efficacité des écoles secondaires est estimé à 0,60 et les écoles secondaires du milieu rural sont les plus efficientes. En ce qui ... Ils confirment l'importance de la discipline au sein des écoles et témoignent la valeur de la coopération entre les écoles et les parents d'élèves.

  20. Ville et santé publique au Japon

    Directory of Open Access Journals (Sweden)

    Takano Takehito

    1996-04-01

    Full Text Available Mon intervention porte sur le niveau de santé en secteur urbain et les questions à l'ordre du jour dans le domaine de la santé publique au Japon. La première partie concerne la cartographie des indices de santé en secteur urbain. Une telle cartographie requiert l'utilisation de techniques de traitement de l'image. On peut l'effectuer soit à l'aide du “ système d'information géographique ” (Geographic Information System, GIS, soit par une “image-diagnostic” (Image Diagnosis des différentes ...

  1. Canine cutaneous leishmaniasis.

    Science.gov (United States)

    Sasani, F; Javanbakht, J; Samani, R; Shirani, D

    2016-03-01

    Canine cutaneous leishmaniasis (CCL) is a significant veterinary problem. Infected dogs also serve as parasite reservoirs and contribute to human transmission of cutaneous leishmaniasis. Histologically, the lesions were nodular to diffuse interstitial granulomatous dermatitis with histiocytic pseudorosettes together with numerous amastigotes within macrophages and occasionally within the interstitium. Organisms were often contained within clear and intracellular vacuoles. The other inflammatory cells, which were present in the biopsies of the Leishmania-infected dog, were lymphocytes and plasma cells. The histopathology results emphasized the role of dog, particularly asymptomatic dog, as reservoirs for CCL because of the high cutaneous parasite loads. These results may help to explain the maintenance of high transmission rates and numbers of CCL cases in endemic urban regions.

  2. Primary cutaneous leiomysarcoma.

    Science.gov (United States)

    Agale, Shubhangi Vinayak; Grover, Sumit; Zode, Rahul; Hande, Shilpa

    2011-11-01

    Primary cutaneous leiomyosarcoma of the skin is a rare soft tissue neoplasm, accounting for about 2-3% of all superficial soft tissue sarcomas. It arises between the ages of 50 and 70 years, and shows a greater predilection for the lower extremities. Clinically, it presents with solitary, well-circumscribed nodule and, microscopically, consists of fascicles of spindle-shaped cells with "cigar-shaped" nuclei. Local recurrence is known in this tumor. We document a case of primary cutaneous leiomyosarcoma in a 77-year-old man and discuss the histological features and immunohistochemical profile of this uncommon neoplasm.

  3. Primary cutaneous leiomysarcoma

    Directory of Open Access Journals (Sweden)

    Shubhangi Vinayak Agale

    2011-01-01

    Full Text Available Primary cutaneous leiomyosarcoma of the skin is a rare soft tissue neoplasm, accounting for about 2-3% of all superficial soft tissue sarcomas. It arises between the ages of 50 and 70 years, and shows a greater predilection for the lower extremities. Clinically, it presents with solitary, well-circumscribed nodule and, microscopically, consists of fascicles of spindle-shaped cells with "cigar-shaped" nuclei. Local recurrence is known in this tumor. We document a case of primary cutaneous leiomyosarcoma in a 77-year-old man and discuss the histological features and immunohistochemical profile of this uncommon neoplasm.

  4. [Cutaneous hemangioma: clinical aspects].

    Science.gov (United States)

    Casanova, D; Norat, F; Bardot, J; Magalon, G

    2006-01-01

    Infantile cutaneous hemangioma is a benign vascular tumour present at 10% of the infants. It forms part of the group of the vascular tumours in the classification of International Society for Vascular Anomalies (ISSVA). Clinical diagnosis is easy in its triphasic typical form with a phase of sometimes brutal postnatal growth, a phase of stabilization and a phase of slow secondary regression. Classically, it is presented in the form of a mass or stains cutaneous red, of a subcutaneous mass or, generally, of a mixed form associating the two aspects.

  5. Cutaneous odontogenic sinus.

    Science.gov (United States)

    Scott, M J; Scott, M J

    1980-06-01

    A case report and discussion of cutaneous odontogenic sinus tracts, frequently encountered but often misdiagnosed and mistreated, are presented. Awareness that periapical dental abscesses are the most common etiologic factor of cutaneous sinus tracts involving the face and neck will facilitate their early diagnosis and prevent needless treatment or anxiety for the patient. These lesions are often misinterpreted as chronic, resistant to therapy, pyogenic nodules, or granulomas. A high degree of suspicion is required for making the correct diagnosis, and dental roentgenographic studies should routinely be obtained in all such lesions. Permanent healing cannot be achieved unless the original site of infection is located and eradicated.

  6. Cutaneous lupus erythematosus

    DEFF Research Database (Denmark)

    Biazar, Cyrus; Sigges, Johanna; Patsinakidis, Nikolaos

    2013-01-01

    In this prospective, cross-sectional, multicenter study, we assessed clinical and laboratory characteristics from patients with cutaneous lupus erythematosus (CLE) using the Core Set Questionnaire of the European Society of Cutaneous Lupus Erythematosus (EUSCLE). 1002 (768 females, 234 males...... included gender, age at onset of disease, LE-specific and LE-nonspecific skin lesions, photosensitivity, laboratory features, and the criteria of the American College of Rheumatology (ACR) for the classification of systemic lupus erythematosus. The mean age at onset of disease was 43.0±15.7 years...

  7. The cutaneous porphyrias.

    Science.gov (United States)

    Schulenburg-Brand, Danja; Katugampola, Ruwani; Anstey, Alexander V; Badminton, Michael N

    2014-07-01

    The porphyrias are a group of mainly inherited disorders of heme biosynthesis where accumulation of porphyrins and/or porphyrin precursors gives rise to 2 types of clinical presentation: cutaneous photosensitivity and/or acute neurovisceral attacks. The cutaneous porphyrias present with either bullous skin fragility or nonbullous acute photosensitivity. This review discusses the epidemiology, pathogenesis, clinical presentation, laboratory diagnosis, complications, and current approach to porphyria management. Although focusing mainly on their dermatological aspects, the article also covers the management of acute porphyria, which by virtue of its association with variegate porphyria and hereditary coproporphyria, may become the responsibility of the clinical dermatologist. Copyright © 2014 Elsevier Inc. All rights reserved.

  8. Vocabulaire illustré 350 exercices : niveau débutant

    CERN Document Server

    Filpa-Ekvall, Dominique; Watcyn-Jones, Peter

    1988-01-01

    Un travail stimulant et amusant pour se construire un vocabulaire de base, soit 1350 mots courants, rassemblés par thèmes (la maison, les magasins, les métiers, les animaux, le bricolage...) ou par catégories grammaticales. Des exercices d'apprentissage, de révision et d'élargissement. aussi bien pour les jeunes que pour les adultes. L'ouvrage se compose de deux parties : - l'apprentissage du vocabulaire élémentaire - l'apprentissage du vocabulaire de niveau intermédiaire suivi d'activités de contrôle des acquisitions.

  9. Effet des conditions climatiques sur le niveau du lac Sidi Ali (Moyen Atlas, Maroc

    Directory of Open Access Journals (Sweden)

    Claude Martin

    2011-11-01

    Full Text Available Le lac Sidi Ali est un lac naturel d'altitude (2070-2080 m, sans exutoire superficiel, déterminé par le barrage d'une coulée basaltique. Doté d'un bassin versant apparent de 15,6 km2, il est alimenté par des eaux de ruissellement et par des sources karstiques. Son niveau subit des variations très fortes, annuelles et interannuelles, sous le contrôle des conditions climatiques, et en particulier des pluies et de l'évapotranspiration. Les périodes de sécheresse qui ont marqué les trois dernières décennies, se sont traduites par un abaissement du niveau de près de 7 m. Mais les précipitations abondantes des années 2008-09 et 2009-10 ont provoqué une nette remontée. Une régression multiple d'assez bonne qualité (r = 0,87 lie la variation annuelle du niveau (d'août à août à différents paramètres (conditions climatiques et niveau initial du lac.Lake Sidi Ali is a natural lake at high altitude (2070-2080 m, without surface outlet, determined by the dam of a basalt flow. With an apparent catchment of 15.6 km2, it is fed by runoff and karst springs. Its level shows strong annual and interannual variations, depending on weather conditions, particularly rainfall and evapotranspiration. Droughts that have marked the last three decades have resulted in a lowering of about 7 m of the water level. But heavy rainfall that occurred in 2008-09 and 2009-10 caused a marked rise. A multiple regression of sufficient quality (r = 0.87 binds the annual change (from august to august at differents parameters (weather conditions and initial level of the lake.

  10. Vocabulaire progressif du français avec 200 exercices : niveau débutant complet

    CERN Document Server

    Lombardini, Amélie; Mous, Nelly

    2015-01-01

    Une organisation claire: la leçon sur la page de gauche; les exercices d'entrainement sur la page de droite 29 fiches présentant le vocabulaire de base dans un pays francophone (Niveau A1.1 du Cadre européen commun de référence pour les langues) Un apprentissage progressif: il suit la progression naturelle des méthodes de français Un usage souple : pour la classe ou en auto-apprentissage Une préparation adaptée aux certifications: un entrainement efficace pour mieux réussir aux examens Une large place faite à l'évaluation: de nombreux exercices de révision et des bilans Les "PLUS" du niveau "débutant complet" du Vocabulaire progressif du français: Une mise en page claire et aérée De nombreuses photos, pour un apprentissage-plaisir Un Cd mp3avec près de 200 documents sonores représentants près de 2 heures d'écoute 200 exercices et activités communicatives Un test final pour faire le point

  11. Grammaire progressive du français avec 400 exercices : niveau avancé

    CERN Document Server

    Boularès, Michèle

    1997-01-01

    La Grammaire progressive du français, de niveau avancé, s'adresse à de grands adolescents et adultes ayant suivi environ 250 heures de cours.Par une méthode progressive, des exemples nombreux et pertinents pour renforcer les règles de grammaire, une langue authentique, cet ouvrage a pour objectif de rendre vivant et stimulant l'apprentissage de la grammaire.Elle présente et explique des points complexes (subjonctif, gérondif, adjectif verbal, participe présent...) et relie résolument la forme et le sens afin de ne pas dissocier grammaire et communication. La Grammaire progressive du français est une grammaire pédagogique: les explications grammaticales sont simples, le plus souvent de l'ordre de la phrase, elles utilisent un minimum de métalangage; des exemples clairs et nombreux illustrent chque explication grammaticale; la langue utilisée dans les exemples et les exercices est authentique. Quand l'exemple illustrant un point grammatical exige un niveau de langage soutenue, celui-ci est signalé...

  12. Champs morphogenetiques mis en evidence par l'etude au microscope electronique a balayage des soies au niveau des pattes d'abeilles (apoidea, megachilidae).

    Science.gov (United States)

    Pasteels, J M; Pasteels, J J

    1973-01-01

    The hairs covering the legs of several species of female megachilid bees are arranged in imbricated fields. At the boundaries of these fields, either the hairs show a morphology intermediate between those of the contiguous fields, or there is a narrow strip with an irregular mosaïc of several hair types. It is suggested that: 1. The structure of the hairs may be determined by the territory in which the trichogenous cell is located. 2. Some morphogenetic fields are bidimensional and cross the segmentary boundaries. The name 'regional fields' is proposed for them. 3. The regional fields may be modulated within each segment into which they extend.

  13. KESALAHAN DEIKSIS DALAM KARANGAN MAHASISWA PADA NIVEAU A2 DI JURUSAN SASTRA JERMAN UM

    Directory of Open Access Journals (Sweden)

    Lilis Afifah

    2015-05-01

    Full Text Available Penelitian ini bertujuan untuk mengetahui kesalahan-kesalahan yang terdapat dalam penggunaan deiksis persona, deiksis tempat, dan deiksis waktu dalam karangan mahasiswa pada Niveau A2 di Jurusan Sastra Jerman UM serta mengetahui faktor-faktor penyebabnya. Subjek penelitian adalah karangan mahasiswa yang dihasilkan dalam matakuliah Aufsatz II. Objek penelitiannya adalah kesalahan deiksis persona, kesalahan deiksis tempat, dan kesalahan deiksis waktu. Proses pengumpulan data menggunakan metode simak yang terdiri dari teknik dasar yang berwujud teknik sadap dan dilanjutkan dengan teknik simak bebas libat cakap. Instrumen penelitian adalah peneliti (human instrument. Keabsahan data dicapai melalui intrarater dan interrater. Selanjutnya data dianalisis dengan metode agih. Hasil penelitian ini adalah sebagai berikut. Dalam karangan mahasiswa ditemukan kesalahan-kesalahan yang terkandung dalam deiksis persona, deiksis tempat, dan deiksis waktu. Faktor yang menyebabkan kesalahan tersebut adalah interferensi, over generalisasi, strategi komunikasi, elemen pembelajaran bahasa asing, kurangnya kontras, kondisi sosial psikologis pembelajar, efek domino, dan redundansi. ________________________________________________________________________________________________________________ DEIXIS ERRORS IN STUDENTS’ ESSAYS IN THE DEPARTMENT OF GERMAN LITERATURE OF UM Abstract This study aimed at determining the erros in using personal deixis, spatial deixis, and temporal deixis in students’ essays on Niveau A2 in the Department of German Literature of UM and also aimed at determining the factors that motivate the occurrence of deixis errors. The subjects were essays written by students which were made in the course of Aufsatz II. The research objects were personal deixis errors, spatial deixis errors, and temporal deixis errors. The data were collected using the observation method which consisted of basic techniques in the form of recording techniques and

  14. Primary cutaneous myoepithelial carcinoma

    DEFF Research Database (Denmark)

    Frost, Markus Winther; Steiniche, Torben; Damsgaard, Tine Engberg

    2013-01-01

    This study describes a case of primary myoepithelial carcinoma of the skin and reviews the available literature on this topic. Myoepitheliomas and carcinomas arise most frequently from myoepithelial cells within the salivary glands but are found in many anatomical locations. We documented a case...... of an 80-year-old man with a 2 × 2 × 1 cm tumour located on the scalp. This tumour emerged over a period of 2 months. The tumour was radically excised, and histological examination revealed a cutaneous myoepithelial carcinoma. At an 18-month follow-up, no recurrence of the tumour was found. A systematic...... literature search identified 23 papers that reported 58 cases of cutaneous myoepitheliomas and myoepithelial carcinomas. All cases are reviewed in the presented paper. This case report and literature review serves to increase awareness regarding myoepithelial carcinomas. These tumours exhibit high metastatic...

  15. Chronic zosteriform cutaneous leishmaniasis

    OpenAIRE

    Omidian M; Mapar M

    2006-01-01

    Cutaneous leishmanasis (CL) may present with unusual clinical variants such as acute paronychial, annular, palmoplantar, zosteriform, erysipeloid, and sporotrichoid. The zosteriform variant has rarely been reported. Unusual lesions may be morphologically attributed to an altered host response or owing to an atypical strain of parasites in these lesions. We report a patient with CL in a multidermatomal pattern on the back and buttock of a man in Khozestan province in the south of Iran. To our ...

  16. Naevus Lipomatosus Cutaneous Superficialis

    Directory of Open Access Journals (Sweden)

    K Siddappa

    1982-01-01

    Full Text Available A case of naevus lipomatosus cutaneous superficilis on the left sacro gluteo-coxal area in a 25 year old male is reported because of its rarity. The clinical features and hisoopathological changes of this condition are described. The possible factors regarding its predilection to the pelvic girdle region, the various theories regarding, its pathogensis and its differentiation from focal dermal. hypoplasia syndrome and grouped lesions of macular atrophy are discussed.

  17. Chitosan against cutaneous pathogens

    OpenAIRE

    Champer, Jackson; Patel, Julie; Fernando, Nathalie; Salehi, Elaheh; Wong, Victoria; Kim, Jenny

    2013-01-01

    Propionibacterium acnes and Staphylococcus aureus are cutaneous pathogens that have become increasingly resistant to antibiotics. We sought to determine if chitosan, a polymer of deacetylated chitin, could be used as a potential treatment against these bacteria. We found that higher molecular weight chitosan had superior antimicrobial properties compared to lower molecular weights, and that this activity occurred in a pH dependent manner. Electron and fluorescence microscopy revealed that chi...

  18. [Cutaneous manifestations of leukemia].

    Science.gov (United States)

    Pulido-Díaz, Nancy; Medina, Gabriela; Palomino, Nymrod; Peralta, Fidelio

    2015-01-01

    To describe the type and frequency of cutaneous manifestations of leukemia. Observational, descriptive study. We included patients over 16 years of age, with confirmed diagnosis of leukemia from the Hematology and Dermatology Departments of the outpatient clinic and from in-patients. Patients with bone marrow transplantation were excluded. A complete history and physical examination of the skin and appendages was performed, with biopsy and cultures if required. The cutaneous manifestations were classified as infection or drug-related, leukemic infiltration, associated dermatosis to leukemia and non-specific lesions. Descriptive statistics was employed. We included 142 patients (62 females, 80 males) with the following diagnoses: acute myeloid leukemia (n=36), acute lymphoblastic leukemia (n=52), chronic myeloid leukemia (n=21), chronic lymphocitic leukemia (n=30) and hairy cells leukemia (n=3). 42% of patients (n=60) presented some dermatoses. There were 36 non-specific dermatoses, 21 drug-related, 20 infectious, 3 infiltrative and none associated. Cutaneous manifestations directly related to leukemia are frequent, being the non-specific ones, the most commonly observed. However, a thorough dermatologic examination is important in these patients as part of an overall evaluation.

  19. Connecter les collectivités isolées au Vietnam afin d'améliorer les ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    29 janv. 2018 ... Mise à l'essai dans huit communes du district montagneux de Dinh Hoa de la province Thaï Nguyen, au nord-est du Vietnam, la plateforme mMOM a offert aux femmes des conseils sur la grossesse et les soins aux nouveau-nés, et ainsi accru leur niveau de sensibilisation et de connaissances et la mise en ...

  20. 10 Contribution à la régulation de la température au sein d'un ...

    African Journals Online (AJOL)

    ALI

    de carbone en un substrat S2 par des bactéries X1 selon la réaction chimique suivante [5]: →. Avec. : la vitesse ... comme produit le méthane (CH4) et en dioxyde de carbone ( ). Cette transformation .... Bilan thermique. A partir de ces hypothèses, un bilan énergétique a été établi au niveau de chaque élément pris à part [2]: ...

  1. L'APPRENTISSAGE AU CERN - French version only

    CERN Document Server

    2003-01-01

    APPRENTISSAGES TECHNIQUES FORMATION ET DEVELOPPEMENT HR/TD/AP L'APPRENTISSAGE AU CERN pour les professions d'électronicien(ne) et de laborantin(e) en physique L'apprentissage au CERN est régi par les lois, règlements et contrats en vigueur dans le Canton de Genève. En cas de réussite à l'examen de fin d'apprentissage, les apprentis obtiennent le Certificat Fédéral de Capacité Suisse (CFC). 7 places au total sont ouvertes au recrutement pour les deux professions. L'apprentissage dure 4 ans. Minima requis pour faire acte de candidature : - avoir terminé la scolarité obligatoire - être ressortissant d'un pays membre du CERN (Allemagne, Autriche, Belgique, Bulgarie, Danemark, Espagne, Finlande, France, Grèce, Hongrie, Italie, Norvège, Pays-Bas, Pologne, Portugal, République slovaque, République tchèque, Royaume-Uni, Suède, Suisse) - avoir au moins 15 ans et moins de 21 ans à la date de début de l'apprentissage - avoir un niveau scolaire correspondant à la 9ème générale ou moderne...

  2. ENSEIGNEMENT TECHNIQUE : Programmation automate Schneider TSX Premium 2ème niveau - French version only

    CERN Multimedia

    2003-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. ENSEIGNEMENT TECHNIQUE Monique Duval Tel./Tél. 74924 technical.training@cern.ch CERN Technical Training 2003: Learning for the LHC ! Annonce de nouvelle formation - cours avancé Dans le cadre du programme de l'Enseignement Technique 2003, et en collaboration avec le GUAPI (Groupe des Utilisateurs d'Automates Programmables Industriels du CERN), une nouvelle formation a été organisée afin de perfectionner les connaissances sur l'outil PL7 de programmation des Automates PREMIUM de Schneider. Ce nouveau cours (niveau 2) s'...

  3. TECHNICAL TRAINING: Programmation automate Schneider TSX Premium 2ème niveau - French version only

    CERN Multimedia

    2003-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. TECHNICAL TRAINING Monique Duval tel. 74924 technical.training@cern.ch CERN Technical Training 2003: Learning for the LHC ! Annonce de nouvelle formation - cours avancé Dans le cadre du programme de l'Enseignement Technique 2003, et en collaboration avec le GUAPI (Groupe des Utilisateurs d'Automates Programmables Industriels du CERN), une nouvelle formation a été organisée afin de perfectionner les connaissances sur l'outil PL7 de programmation des Automates PREMIUM de Schneider. Ce nouveau cours (niveau 2) s'adresse aux person...

  4. Cutavirus in Cutaneous Malignant Melanoma

    DEFF Research Database (Denmark)

    Mollerup, Sarah; Fridholm, Helena; Vinner, Lasse

    2017-01-01

    A novel human protoparvovirus related to human bufavirus and preliminarily named cutavirus has been discovered. We detected cutavirus in a sample of cutaneous malignant melanoma by using viral enrichment and high-throughput sequencing. The role of cutaviruses in cutaneous cancers remains to be in......A novel human protoparvovirus related to human bufavirus and preliminarily named cutavirus has been discovered. We detected cutavirus in a sample of cutaneous malignant melanoma by using viral enrichment and high-throughput sequencing. The role of cutaviruses in cutaneous cancers remains...

  5. [Hepatic porphyrias with cutaneous symptoms].

    Science.gov (United States)

    Timonen, Kaisa; Nuutinen, Pauliina; Raili, Kauppinen

    2012-01-01

    Hepatic porphyrias with cutaneous symptoms Cutaneous symptoms of porphyrias are initiated from a phototoxic reaction caused by sunlight and circulating porphyrins in the vascular walls of the skin. This leads in fragility, blistering and scarring of the skin on light-exposed areas. There are approximately 200 patients having hepatic porphyrias with cutaneous symptoms in Finland. Cutaneous symptoms of variegate porphyria and porphyria cutanea tarda are indistinguishable, but an effective treatment is available only for the latter. Differential diagnosis is important due to acute episodes occurring in variegate porphyria.

  6. Cutaneous Nocardiosis Simulating Cutaneous Lymphatic Sporotrichosis.

    Science.gov (United States)

    Secchin, Pedro; Trope, Beatriz Moritz; Fernandes, Larissa Araujo; Barreiros, Glória; Ramos-E-Silva, Marcia

    2017-01-01

    Sporotrichosis is the subcutaneous mycosis caused by several species of the Sporothrix genus. With worldwide occurrence, the State of Rio de Janeiro is presently undergoing a zoonotic sporotrichosis epidemic. The form of lymphocutaneous nocardiosis is rare, being caused especially by Nocardia brasiliensis. It appears as a nodular or ulcerated lesion, with multiple painful erythematous nodules or satellite pustules distributed along the lymphatic tract, similar to the lymphocutaneous variant of sporotrichosis. We present a 61-year-old man who, after an insect bite in the left leg, developed an ulcerated lesion associated with ascending lymphangitis, nonresponsive to previous antibiotic therapies. The patient was admitted for investigation, based on the main diagnostic hypothesis of lymphatic cutaneous sporotrichosis entailed by the highly suggestive morphology, associated with the epidemiologic information that he is a resident of the city of Rio de Janeiro. While culture results were being awaited, the patient was medicated with sulfamethoxazole-trimethoprim to cover CA-MRSA and evolved with total healing of the lesions. After hospital discharge, using an ulcer fragment, an Actinomyces sp. was cultivated and N. brasiliensis was identified by molecular biology. The objective of this report is to demonstrate a case of lymphocutaneous nocardiosis caused by N. brasiliensis after a probable insect bite. Despite the patient being a resident of the State of Rio de Janeiro (endemic region for sporotrichosis), it is highlighted that it is necessary to be aware of the differential diagnoses of an ulcerated lesion with lymphangitis, favoring an early diagnosis and appropriate treatment of the illness.

  7. Cutaneous Nocardiosis Simulating Cutaneous Lymphatic Sporotrichosis

    Directory of Open Access Journals (Sweden)

    Pedro Secchin

    2017-08-01

    Full Text Available Sporotrichosis is the subcutaneous mycosis caused by several species of the Sporothrix genus. With worldwide occurrence, the State of Rio de Janeiro is presently undergoing a zoonotic sporotrichosis epidemic. The form of lymphocutaneous nocardiosis is rare, being caused especially by Nocardia brasiliensis. It appears as a nodular or ulcerated lesion, with multiple painful erythematous nodules or satellite pustules distributed along the lymphatic tract, similar to the lymphocutaneous variant of sporotrichosis. We present a 61-year-old man who, after an insect bite in the left leg, developed an ulcerated lesion associated with ascending lymphangitis, nonresponsive to previous antibiotic therapies. The patient was admitted for investigation, based on the main diagnostic hypothesis of lymphatic cutaneous sporotrichosis entailed by the highly suggestive morphology, associated with the epidemiologic information that he is a resident of the city of Rio de Janeiro. While culture results were being awaited, the patient was medicated with sulfamethoxazole-trimethoprim to cover CA-MRSA and evolved with total healing of the lesions. After hospital discharge, using an ulcer fragment, an Actinomyces sp. was cultivated and N. brasiliensis was identified by molecular biology. The objective of this report is to demonstrate a case of lymphocutaneous nocardiosis caused by N. brasiliensis after a probable insect bite. Despite the patient being a resident of the State of Rio de Janeiro (endemic region for sporotrichosis, it is highlighted that it is necessary to be aware of the differential diagnoses of an ulcerated lesion with lymphangitis, favoring an early diagnosis and appropriate treatment of the illness.

  8. Chronic zosteriform cutaneous leishmaniasis

    Directory of Open Access Journals (Sweden)

    Omidian M

    2006-01-01

    Full Text Available Cutaneous leishmanasis (CL may present with unusual clinical variants such as acute paronychial, annular, palmoplantar, zosteriform, erysipeloid, and sporotrichoid. The zosteriform variant has rarely been reported. Unusual lesions may be morphologically attributed to an altered host response or owing to an atypical strain of parasites in these lesions. We report a patient with CL in a multidermatomal pattern on the back and buttock of a man in Khozestan province in the south of Iran. To our knowledge, this is the first reported case of multidermatomal zosteriform CL. It was resistant to conventional treatment but responded well to a combination of meglumine antimoniate, allopurinol, and cryotherapy.

  9. Cutaneous and mucocutaneous leishmaniasis.

    Science.gov (United States)

    Goto, Hiro; Lauletta Lindoso, José Angelo

    2012-06-01

    Tegumentary leishmaniases are caused by approximately 15 species of protozoa of the genus Leishmania. They prevail in tropical and subtropical areas of the Old and New World but human mobility also makes them a medical problem in nonendemic areas. Clinical manifestations may comprise cutaneous and mucocutaneous forms that may be localized, disseminated, or diffuse in distribution and may differ in Old and New World leishmaniases. Diagnosis and treatment vary according to the clinical manifestations, geographic area, and Leishmania species involved. This article highlights the diversity and complexity of tegumentary leishmaniases, which are worsened by human immunodeficiency virus/Leishmania coinfection. Copyright © 2012 Elsevier Inc. All rights reserved.

  10. Cutaneous malignancies of the perineum.

    Science.gov (United States)

    Carr, David; Pootrakul, Llana; Harmon, Jenna; Trotter, Shannon

    2015-03-01

    This review discusses multiple cutaneous malignancies that can present on the perineum. Although all of these neoplasms are uncommon, a focus will be on the more common neoplasms including extramammary Paget disease, basal cell carcinoma, squamous cell carcinoma, and melanoma. Other more rare entities discussed are superficial leiomyosarcoma, giant solitary trichoepithelioma, and cutaneous endometriosis.

  11. Evaluation du niveau de connaissance des patients sur la gestion du traitement par les antis vitamines K dans le service de cardiologie de Ouagadougou

    Science.gov (United States)

    Samadoulougou, André; Temoua Naibe, Dangwé; Mandi, Germain; Yameogo, Relwendé Aristide; Kabore, Elisé; Millogo, Georges; Yameogo, Nobila Valentin; Kologo, Jonas Koudougou; Thiam/Tall, Anna; Toguyeni, Boubacar Jean Yves; Zabsonre, Patrice

    2014-01-01

    Introduction Les antivitamines K (AVK), traitement anticoagulant oral le plus largement prescrit, posent un réel problème de santé publique du fait de leur risque iatrogène. L'objectif de cette étude était de préciser le niveau de connaissance des patients sur la gestion de leur traitement par les AVK. Méthodes Il s'est agi d'une enquête transversale descriptive réalisée au CHU-Yalgado Ouédraogo, sur une période de 03 mois : du 1er mars au 31 mai 2012. Un questionnaire a été administré aux patients bénéficiant d'un traitement AVK depuis au moins un mois. Résultats Soixante-dix patients ont été inclus dans l'étude dont 30 hommes. L'âge moyen était de 49 ans ± 16 ans. Les cardiopathies et la maladie thromboembolique veineuse justifiant l'institution du traitement AVK étaient retrouvées respectivement dans 58,6% et 41,4% des cas. Le nom de l'AVK et la raison exacte du traitement étaient connus respectivement dans 91,4% et 67,1% des cas. Plus de la moitié des patients (68,6%) savaient que les AVK rendaient le sang plus fluide. Quarante-six patients (65,7%) citaient l'INR comme examen biologique de surveillance du traitement et seulement 28 patients (40%) connaissaient les valeurs cibles. La majorité des patients ne connaissait pas les risques encourus en cas de surdosage (72,8%) et de sous-dosage (71,4%). Une automédication par anti-inflammatoire non stéroïdien était signalée par 18 patients (25,7%). Les choux (74,3%) et la laitue (62,9%), aliments à consommer avec modération, étaient les plus cités. Conclusion Les connaissances des patients sur la gestion des AVK étaient fragmentaires et insuffisantes pour assurer la sécurité et l'efficacité du traitement. La création d'un programme d'éducation thérapeutique sur les AVK s'avère alors nécessaire. PMID:25870741

  12. Corynebacterium ulcerans cutaneous diphtheria.

    Science.gov (United States)

    Moore, Luke S P; Leslie, Asuka; Meltzer, Margie; Sandison, Ann; Efstratiou, Androulla; Sriskandan, Shiranee

    2015-09-01

    We describe the case of a patient with cutaneous diphtheria caused by toxigenic Corynebacterium ulcerans who developed a right hand flexor sheath infection and symptoms of sepsis such as fever, tachycardia, and elevated C-reactive protein, after contact with domestic cats and dogs, and a fox. We summarise the epidemiology, clinical presentation, microbiology, diagnosis, therapy, and public health aspects of this disease, with emphasis on improving recognition. In many European countries, C ulcerans has become the organism commonly associated with cutaneous diphtheria, usually seen as an imported tropical disease or resulting from contact with domestic and agricultural animals. Diagnosis relies on bacterial culture and confirmation of toxin production, with management requiring appropriate antimicrobial therapy and prompt administration of antitoxin, if necessary. Early diagnosis is essential for implementation of control measures and clear guidelines are needed to assist clinicians in managing clinical diphtheria. This case was a catalyst to the redrafting of the 2014 national UK interim guidelines for the public health management of diphtheria, released as final guidelines in March, 2015. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Cutaneous tuberculosis in Tunisia.

    Science.gov (United States)

    Abdelmalek, R; Mebazaa, A; Berriche, A; Kilani, B; Ben Osman, A; Mokni, M; Tiouiri Benaissa, H

    2013-09-01

    Tuberculosis is endemic in Tunisia. Pulmonary tuberculosis is the most common presentation in our country. Cutaneous presentations are rare (1-2% of cases). The diagnosis of cutaneous tuberculosis (CT) is difficult. Histological and clinical presentations are polymorphous, many differential diagnoses are available, and it is difficult to isolate Mycobacterium. We had for aim to study the epidemiological and clinical features of CT in Tunisia, and to compare presentations before and after 1990. We conducted a retrospective study between January 1991 and December 2011, in which we included all cases of CT observed at the Infectious Diseases and Dermatology Units of the Tunis la Rabta Hospital. Hundred and thirty-seven patients were included, with a mean age of 43.8years; 72.3% were female patients. Hundred and fifty locations were observed, most of which on the head and neck. Scrofuloderma was the most frequent presentation, observed in 65% of cases. The diagnosis was confirmed by histology and/or microbiology in 75.8% of cases. The treatment was prescribed for a mean 11.3months, leading to full recovery in most cases. CT is still reported in Tunisia. The diagnosis relies mainly on histology. Controlling this mutilating tuberculosis requires a global control of this disease, and especially lymph node location, given the high rate of scrofuloderma. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  14. Adverse cutaneous drug reaction

    Directory of Open Access Journals (Sweden)

    Nayak Surajit

    2008-01-01

    Full Text Available In everyday clinical practice, almost all physicians come across many instances of suspected adverse cutaneous drug reactions (ACDR in different forms. Although such cutaneous reactions are common, comprehensive information regarding their incidence, severity and ultimate health effects are often not available as many cases go unreported. It is also a fact that in the present world, almost everyday a new drug enters market; therefore, a chance of a new drug reaction manifesting somewhere in some form in any corner of world is unknown or unreported. Although many a times, presentation is too trivial and benign, the early identification of the condition and identifying the culprit drug and omit it at earliest holds the keystone in management and prevention of a more severe drug rash. Therefore, not only the dermatologists, but all practicing physicians should be familiar with these conditions to diagnose them early and to be prepared to handle them adequately. However, we all know it is most challenging and practically difficult when patient is on multiple medicines because of myriad clinical symptoms, poorly understood multiple mechanisms of drug-host interaction, relative paucity of laboratory testing that is available for any definitive and confirmatory drug-specific testing. Therefore, in practice, the diagnosis of ACDR is purely based on clinical judgment. In this discussion, we will be primarily focusing on pathomechanism and approach to reach a diagnosis, which is the vital pillar to manage any case of ACDR.

  15. Taxi ! méthode de français : niveau 3

    CERN Document Server

    Johnson, Anne-Marie

    2004-01-01

    Taxi ! 3 est une méthode interactive, qui développe non seulement les connaissances, mais aussi les savoir-faire et les savoir-être de l'apprenant, à l'écrit comme à l'oral. La méthode est très simple à utiliser : une leçon = une double page. Taxi ! 3 couvre le niveau Bl du Cadre européen commun de référence pour l'apprentissage, l'enseignement et l'évaluation des langues. La méthode permet de se préparer aux épreuves A3 et A4 du DELF 1er degré. Une progression et des contenus fonctionnels et langagiers solides permettent à l'apprenant d'atteindre rapidement une autonomie en français dans des situations de la vie courante. Taxi ! 3 permet de mieux connaître la France d'aujourd'hui et les comportements des Français à travers une grande variété de documents authentiques (écrit et audio).

  16. Grammaire progressive du français niveau intermédiaire

    CERN Document Server

    Grégoire, Maïa

    2017-01-01

    Quatrième édition de l'ouvrage de Grammaire de français langue étrangère (FLE), niveau intermédiaire, dans la collection Progressive du français destiné aux grands adolescents et adultes. Ce qui fait le succès de cet ouvrage de Grammaire: une organisation claire : la leçon de grammaire sur la page de gauche; les exercices d'entraînement sur la page de droite 52 chapitres présentant les points généralement abordés aux niveaux A2 et B1 du Cadre européen commun de référence pour les langues un apprentissage progressif : il suit la progression naturelle des méthodes de français un usage souple : pour la classe ou en auto-apprentissage une préparation adaptée aux certifications : un entreînement efficace pour mieux réussir aux examens NOUVEAU! Appli-web de la Grammaire progressive du français incluse Pour s'entraîner et s'évaluer en ligne en sollicitant toutes les compétences écrites et orales : près de 300 exercices interactifs avec dialogues, instructions, exemples et corrigés ora...

  17. Grammaire progressive du français corrigés : niveau intermédiaire

    CERN Document Server

    Thiévenaz, Odile

    2017-01-01

    Quatrième édition des corrigés de l'ouvrage de Grammaire de français langue étrangère (FLE), niveau intermédiaire, dans la collection Progressive du français destiné aux grands adolescents et adultes. Ce qui fait le succès de cet ouvrage de grammaire: Une organisation claire : la leçon de grammaire sur la page de gauche, les exercices d'entraînement sur la page de droite 52 chapitres présentant les points généralement abordés aux niveaux A2 et B1 du Cadre européen commun de référence pour les langues Un apprentissage progressif : il suit la progression naturelle des méthodes de français Un usage souple : pour la classe ou en auto-apprentissage Une préparation adaptée aux certifications : un entraînement efficace pour mieux réussir aux examens NOUVEAU!​ Appli-Web de la Grammaire progressive du français Pour s'entraîner et s'évaluer en ligne en sollicitant toutes les compétences écrites et orales: près de 300 exercices interactifs avec dialogues, instructions, exemples et corri...

  18. Cutaneous larva migrans

    Directory of Open Access Journals (Sweden)

    Aleksandra Wieczorek

    2016-09-01

    Full Text Available Introduction . Cutaneous larva migrans (CLM is a tropical zoonosis, caused by parasites, usually Ancylostoma braziliense. Humans are an accidental host. Polish patients with CLM are usually tourists visiting tropical and subtropical countries. The first symptoms do not always appear as creeping eruptions, which complicates the diagnosis. Objective. To present the case of a man with CLM after returning from Thailand to Poland and associated diagnostic difficulties. Case report. We present a case of a 28-year-old man who returned to Poland from Thailand. The first symptoms appeared as disseminated pruritic papules. No improvement after treatment with corticosteroids and antihistamines was observed. The diagnosis was established after the appearance of serpentine erythemas and improvement after albendazole therapy. Conclusions. In the case of returnees from exotic countries suffering from raised, pruritic rashes, and no improvement after treatment with corticosteroids and antihistamines, parasitic etiology should be considered.

  19. Tropical dermatology: cutaneous larva migrans, gnathostomiasis, cutaneous amebiasis and trombiculiasis.

    Science.gov (United States)

    Eichelmann, Kristian; Tomecki, Kenneth J; Martínez, José Darío

    2014-09-01

    In today's world, many people can travel easily and quickly around the globe. Most travel travel-related illnesses include fever, diarrhea, and skin disease, which are relatively uncommon in returning travelers. We review four of the most common emerging infestations and skin infections in the Americas, which are important to the clinical dermatologist, focusing on the clinical presentation and treatment of cutaneous larva migrans, gnathostomiasis, cutaneous amebiasis, and trombiculiasis.

  20. [Cervicofacial cellulitis revealing cutaneous lymphomas].

    Science.gov (United States)

    Benbouzid, M A; Bencheikh, R; Benhammou, A; El Edghiri, H; Boulaich, M; Essakali, L; Kzadri, M

    2007-06-01

    The cervicofacial localization of cutaneous lymphomas is rare. These lymphomas usually present as a long-lasting and treatment-refractory papule or nodule. Lymphomas can also be revealed by cervicofacial cellulitis. We report 2 cases of cervicofacial cellulitis revealing a cutaneous lymphoma. The diagnosis was proved by multiple biopsies, performed because there was no clinical improvement in spite of an aggressive and adequate antibiotherapy. Our 2 patients were treated by radio and chemotherapy. Cutaneous lymphomas are lymphocytic proliferations stemming from cutaneous lymphoid tissue, without nodal, medullary, or visceral localization. Their clinical presentation is quite polymorphic, and cellulitis is one of the modes of revelation, especially forehead and neck localization. They have no portal of entry and are resistant to treatment. The diagnosis relies on histology, and biopsies must be performed if there is a suspicion of lymphoma. The treatment is radio and chemotherapy, and the evolution depends on the tumoral stage.

  1. Multiple Cutaneous (pre)-Malignancies

    NARCIS (Netherlands)

    R.J.T. van der Leest (Robert)

    2015-01-01

    markdownabstract__Abstract__ The three most common cutaneous malignancies are derived from melanocytes and keratinocytes (ordered in decreasing aggressiveness): melanoma, squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). This thesis focuses only on these three types of cancer and

  2. Use of liquid surface pressure in the achievement of a constant level evaporator; Utilisation de la tension superficielle d'un liquide dans la realisation d'un evaporateur a niveau constant

    Energy Technology Data Exchange (ETDEWEB)

    Fonseca, A

    1963-07-01

    An evaporator is described that consists mainly of a tank and an evaporation cup. The liquid contained in the tank runs out into the cup with a flow varying only as the speed at which evaporation is going on. The level of the liquid in the cup remains constant according to the laws of hydrostatics. What is original in such a device is the use of surface pressure of the liquid to be dried off. Thanks to this pressure the whole tank is above the constant level, which allows it to be entirely drained off into the evaporation cup. The property used there makes also possible using of a simple device (pressure contactor and relay) to cut heating off automatically when evaporation is nearly finished. (author) [French] L'evaporateur decrit ici se compose principalement d'un reservoir et d'une coupelle d'evaporation. Le liquide que contient le reservoir s'ecoule dans la coupelle avec un debit qui est uniquement fonction de la vitesse u laquelle se fait l'evaporation. Le niveau du liquide dans la coupelle se maintient a une hauteur constante, conformement aux lois de l'hydrostatique. L'originalite de cet appareil reside dans l'utilisation de la tension superficielle du liquide a evaporer. Grace a celle-ci, en effet, le reservoir se trouve tout entier au-dessus du niveau constant, ce qui lui permet de se vider entierement dans la coupelle d'evaporation. La propriete utilisee permet aussi a un dispositif simple (monocontacteur et relais) de couper automatiquement le chauffage en fin d'evaporation. (auteur)

  3. Cutaneous lesions in new born

    OpenAIRE

    Sachdeva Meenakshi; Kaur Surjeet; Nagpal Madhu; Dewan S

    2002-01-01

    Five hundred unselected newborn babies delivered in the Department of Obstetrics and Gynaecology, Unit II of SGBT Hospital attached to Government Medical College, Amritsar during April 2000 to October 2000 were examined for cutaneous lesions daily for the first five days after birth. Different cutaneous lesions were seen in 474(94. 8%) newborns. The physiological skin changes observed in order of frequency were Epstein pearls in 305(61%), Mongolian spot in 301(60. 2%), su...

  4. Cutaneous actinomycosis: A rare case

    Directory of Open Access Journals (Sweden)

    Metgud S

    2007-01-01

    Full Text Available Cutaneous actinomycosis is a rare presentation. Here we present a case of cutaneous actinomycosis with no history of trauma or systemic dissemination. The isolate was identified as Actinomyces viscosus by standard methods. The isolate was found to be penicillin resistant by Kirby Bauer disc diffusion method. Therefore, the patient was treated with cotrimoxazole and improved. Thus, this case highlights the importance of isolation and susceptibility testing in actinomycotic infection. The sinuses have healed, and the patient has recovered.

  5. Affections cutaneo-muqueuses au cours de l'Infection a VIH /SIDA ...

    African Journals Online (AJOL)

    Les affections dermatologiques sont fréquentes au cours de l'infection par le virus de l'Immunodéficience Humaine (VIH). Nous avons réalisé une étude prospective de janvier à décembre 2003 au service de l'hôpital du jour de Hôpital Central de Yaoundé, afin de répertorier les affections cutanes et muqueuses associées ...

  6. Impact Economique de L'epizootie de Peste Equine de 2007 au ...

    African Journals Online (AJOL)

    Sénégal en vue de fournir aux décideurs des arguments pour une stratégie de lutte pluriannuelle et durable. L'approche méthodologique adoptée est basée sur l'utilisation des données secondaires disponibles au niveau du service public et du service privé. Les calculs électroniques et manuels ont été utilisés pour le ...

  7. Note concernant l'évolution d'une population d'orchidées (Dactylorhiza majalis) au sein d'une prairie humide soumise à un pâturage tardif en région ardennaise (réserve naturelle de la Gotale - Manhay)

    OpenAIRE

    Rouxhet, Serge

    2007-01-01

    Depuis 1990, une population d'orchis de mai (Dactylorhiza majalis) est suivie au niveau du site de la Gotale (commune de Manhay, province de Luxembourg). Cette population est localisée au sein d'une ancienne prairie humide ardennaise, sous statut de réserve naturelle RNOB depuis 1991. Après 17 années de comptages, des résultats sont présentés.

  8. Toxigenic cutaneous diphtheria in a returned traveller.

    Science.gov (United States)

    Abdul Rahim, Nur R; Koehler, Ann P; Shaw, Doug D; Graham, Caitlin R

    2014-12-31

    Diphtheria is rarely reported in Australia. A case of cutaneous diphtheria was reported to the South Australian Department for Health and Ageing in April 2013 in an Australian-born 18-year-old female following travel in India. The case presented with a skin ulcer on her toe. Toxigenic Corynebacterium diphtheriae was isolated from a swab of the lesion. The case was treated with antibiotics. The public health response included infection control advice, assessing the case and household contacts for organism carriage and providing antimicrobial chemoprophylaxis to contacts. Although cutaneous diphtheria is not included as part of the Australian communicable disease surveillance case definition, this may be an oversight as international evidence demonstrates that it is a source of organism transmission and can potentially result in outbreaks among susceptible populations. This formed the rationale for the public health response to this particular case. The protocol for the public health management of diphtheria in South Australia has since been revised to include cutaneous lesions caused by the toxigenic strain of the organism as part of the surveillance case definition. This work is copyright. You may download, display, print and reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction for any commercial purpose and retain this copyright notice and all disclaimer notices as part of that reproduction. Apart from rights to use as permitted by the Copyright Act 1968 or allowed by this copyright notice, all other rights are reserved and you are not allowed to reproduce the whole or any part of this work in any way (electronic or otherwise) without first being given the specific written permission from the Commonwealth to do so. Requests and inquiries concerning reproduction and rights are to be sent

  9. L’équité au cœur des politiques climatiques : l’exemple des négociations relatives au climat et de la recherche de solutions à la crise énergétique

    Directory of Open Access Journals (Sweden)

    Loïc Aubrée

    2011-02-01

    Full Text Available L’article débat de la question de l’équité dans la lutte contre les changements climatiques. Il établit un parallèle entre le développement pris au niveau international de la négociation entre Etats d’une part, et la pauvreté au niveau d’une collectivité d’autre part. Dans les deux cas, il s’agit à la fois d’un principe moral essentiel, mais aussi d’une condition centrale des consensus et donc de la réussite des politiques face au défi climatique. La question de l’équité renvoie aussi très vite au changement nécessaire des modes de vie vers plus de sobriété.The article debates Equity Issues in the Climate Change debate is debated. A parallel is set between the development issues at the international level of negotiations between States, and poverty alleviation at the local community level. In both cases, the discussions stem from an essential moral principle, but also as a requisite for consensus and thus a condition of success of climate change policies to combat Climate Change. The issue of equity brings also forward the necessary modification of consumption patterns, into more frugal modes.

  10. Cutaneous papillomatosis in cattle.

    Science.gov (United States)

    Jelínek, F; Tachezy, R

    2005-01-01

    Three of four heifers housed together developed multiple cutaneous tumours in the linea alba and on the teats 3 months after the application of plastic muzzle plates with sharp tips to prevent mutual sucking and licking. Fibropapilloma with many koilocytes but few intranuclear inclusions was diagnosed histologically. The dermis showed neoplastic fibroblasts and a structureless intercellular matrix, and nonpurulent vasculitis was also recorded. Immunohistochemical examination with an antibody against L1 papillomavirus antigen demonstrated intranuclear positivity in single cells of the granular and cornified layers and in many mesenchymal cells in the fibrous parts of the tumours. CD3-positive lymphocytes were present in the wall of some blood vessels, and in the dermis and epidermis. Proliferating cell nuclear antigen was detected predominantly in the basal layer of the epidermis and in the superficial dermis. Electron microscopy revealed small intranuclear aggregates of virus particles in an epidermocyte, damage to desmosomes and disorganization of cytokeratin filaments in many epidermocytes. Aggregates of virus particles were revealed also in a fibroblast in the dermis. In blood capillaries of the corium, acute swelling, inflammation and necrosis of the endothelium were observed. By means of the polymerase chain reaction (PCR) and nucleotide DNA sequencing of the PCR product, the virus was identified as bovine papilloma virus type 1 (BPV 1). The presence of this virus in the tissue was further confirmed by in-situ hybridization with a BPV 1 probe.

  11. Tuberculose cutanée à Bamako, Mali

    Science.gov (United States)

    Dicko, Adama; Faye, Ousmane; Fofana, Youssouf; Soumoutera, Moussa; Berthé, Siritio; Touré, Saidou; Traoré, Bekaye; Guindo, Binta; Tall, Koureissi; Keita, Alimata; Kéita, Lassine; Coulibaly, Karim; Keita, Somita

    2017-01-01

    Introduction La tuberculose est la mycobactériose la plus fréquente en Afrique subsaharienne. La localisation cutanée est rare et sous diagnostiquée à cause de son polymorphisme clinique et la faiblesse du plateau technique. Le but de cette étude était de décrire les aspects épidémiologiques, cliniques, histopathologiques de la tuberculose cutanée à Bamako (Mali). Méthodes De janvier 1991 à décembre 2008 nous avons réalisé une étude transversale descriptive. L’étude s’est déroulée dans le service de Dermatologie du Centre National d’Appui à la lutte contre la Maladie et le service de Pneumo-phtisiologie au l’hôpital du Point G. Ont été inclus dans l’étude les cas de tuberculose confirmés par l’histologie et ou la biologie. Résultats Sur 4269 dossiers, 61 cas de tuberculose cutanée étaient recensées (1,43%). Les hommes représentaient 59% des cas (36 malades) et les femmes 41 % soit (25 cas); soit un sex-ratio de 1,44. L’âge des malades variait de 3 mois à 61 ans pour une moyenne de 27,56 ± 36 ans. La durée d’évolution était en moyenne de 10,9 ± 10 mois. Les formes cliniques recensées étaient le scrofuloderme (41 cas), la forme ulcéreuse (13 cas), la forme verruqueuse (4 cas), et le lupus tuberculeux (3 cas). La tuberculose était associée au VIH dans 7 cas, à la lèpre dans 3 cas. Conclusion La tuberculose cutanée est sous diagnostiquée au Mali. Des efforts sont nécessaires pour améliorer l’accessibilité et le plateau technique des services spécialisés, pour mener une étude approfondie interdisciplinaire sur cette pathologie. PMID:28819523

  12. Treatment of Cutaneous Lupus Erythematosus

    Science.gov (United States)

    Kim, Grace K.; Del Rosso, James Q.

    2013-01-01

    The treatment of cutaneous lupus erythematosus is centered upon formulating a regimen of topical and systemic therapies designed to reduce disease activity and minimize cosmetic damage. Sun avoidance and sunscreen are important preventative measures proven to minimize cutaneous lupus erythematosus exacerbations. Limited disease is typically managed with topical corticosteroids or calcineurin inhibitors. Antimalarial therapy is the gold standard of systemic therapy. Many other treatments have been studied in patients with recalcitrant cutaneous lupus erythematosus, and their use must be evaluated based on individual risk-benefit concerns. R-salbutamol and pulsed dye laser therapy have proven to be effective topical alternatives. Additional systemic agents include retinoids, immunosuppressants, immunomodulators, biologics, and other experimental therapies with novel modes of action. According to the Oxford Centre for Evidence-based Medicine criteria for evaluating the strength of evidence supporting an individual treatment measure, no therapy for cutaneous lupus erythematosus has achieved Level 1 status. This demonstrates the need for randomized, controlled trials and systematic reviews of all cutaneous lupus erythematosus interventions in order to meet increasing standards and demand for evidence-based practice. PMID:23320123

  13. [Cutaneous leishmaniasis in Turkey].

    Science.gov (United States)

    Gürel, Mehmet Salih; Yeşilova, Yavuz; Olgen, M Kirami; Ozbel, Yusuf

    2012-01-01

    Cutaneous leishmaniasis (CL) caused by Leishmania protozoon parasites is a disease which is characterized by long-term nodulo-ulcerative lesions healing spontaneously with scarring. The disease has been well-known in Anatolia for centuries and has different names such as; Urfa boil, Antep boil, year boil, Halep boil, oriental sore and beauty scar. The causative agents are Leishmania tropica and Leishmania tropica/Leishmania infantum in Southeastern Anatolia and East Mediterranean, respectively. CL is a notifiable disease in Turkey and, according to the Ministry of Health official records, 46.003 new cases were reported between 1990 and 2010. Among those cases, 96% of them were reported from the Şanlıurfa, Adana, Osmaniye, Hatay, Diyarbakır, İçel and Kahramanmaraş provinces. Although 45% of cases were notified from Şanlıurfa in the past 20 years, its ratio is currently decreasing while other regions' ratios have been showing an increasing trend. Easier transportation between cities, increased travel migration of the population from rural areas to the peripheral suburbs with inadequate infrastructure and unhealthy housing are thought to be the main factors for spreading the disease from Southeastern Anatolia to other regions of Turkey. Lack of treatment of patients as reservoir hosts because of different reasons and ineffective and inadequate use of insecticides against vector sand flies have also played an important role in spreading the disease. Neglect of this disease by patients and health institutions can also be considered as other factors for the spreading. We believe that, after the strategic plan for leishmaniasis prepared by the Turkish Ministry of Health with the contribution of scientists in 2011 is put into practice, the control of the disease will be more effective.

  14. Cutaneous Manifestations Of Neurofibromatosis Type 1 In South India

    Directory of Open Access Journals (Sweden)

    Jeevankumar B

    2001-01-01

    Full Text Available Neurofibromatosis type 1 (NF-1 is the most common form of neurofibromatosis. Since the significance of various cutaneous manifestations of NF-1 has not been known in Indian population, hence, the present study was undertaken. A total of 40 patients with NF-1 were identified between August 1998 to June 2000 with a prevalence rate of 20.4 per 10,000 individuals attending our clinic. Male to female ratio was 2.3: 1. The age of the patients ranged from 15 to 70 years with a mean age of 29.57 years. Most patients (18 cases belonged to age group of 21-30 years followed by 11-20 years age group (11 cases. Twenty four cases had onset of disease between 11-20 years of age and ten cases in 21-30 years age group. Thirty one of 40 cases presented with asymptomatic nodules, three sought medical opinion for cosmetic reasons and another three for hyper pigmented patch. Analysis of cutaneous manifestations showed, 39 of 40 cases (97.5% had neurofibromas. Palmar melanotic macules were noted in 36 (90% cases whereas café â€" au-lait macules were seen in 33(82.5% cases. Subsequent, less common findings were intertriginous freckles in 31(77.5% cases, plantar melanotic macules in 18(45% cases and generalized freckles in 4(10% cases. Statistical analysis of cases and controls revealed significant association of NF-1 with neurofibromas, palmar melanotic macules, café-au-lait macules, intertriginous freckles and plantar melanotic macules(p<0.001. This study brings into focus some of the cutaneous manifestations noted in South Indian patients especially palmar and plantar melanotic macules, not highlighted in the western literature.

  15. Cutaneous human myiasis due to Dermatobia hominis.

    Science.gov (United States)

    Suite, M; Polson, K

    2007-10-01

    This is a case report of cutaneous myiasis due to Dermatobia hominis in a female physician who had travelled to Belize. Cutaneous myiasis is endemic in Central and South America but is seldom reported from the Caribbean islands.

  16. Genetics Home Reference: primary localized cutaneous amyloidosis

    Science.gov (United States)

    ... Amyloidosis, primary localized cutaneous, 2 Genetic Testing Registry: Primary localized cutaneous amyloidosis 1 General Information from MedlinePlus (5 links) Diagnostic Tests Drug Therapy Genetic Counseling Palliative Care Surgery and Rehabilitation Related Information How are genetic ...

  17. Onychomadesis Following Cutaneous Vasculitis.

    Science.gov (United States)

    Damevska, Katerina; Gocev, Gorgi; Pollozahani, Nora; Nikolovska, Suzana; Neloska, Lence

    2017-04-01

    Beau lines are transverse, band-like depressions extending from one lateral edge of the nail to the other and affecting all nails at corresponding levels (1). Onychomadesis is considered an extreme form of Beau line with subsequent separation of the proximal nail plate from the nail bed. Both fall along a spectrum of nail plate abnormalities that occur secondary to temporary nail matrix arrest (NMA). Various systemic and dermatologic conditions have been reported in association with onychomadesis (2-7) (Table 1). Nail changes can affect all or some of the nails and both the fingernails and toenails; however, fingernails are more frequently affected. The severity of the nail changes varies depending on the underlying cause, its duration, and environmental factors (8). We present a case of onychomadesis following cutaneous leukocytoclastic vasculitis (CLCV). A 61-year-old woman presented to the Dermatology Clinic complaining of a purpuric rash that began on her lower extremities and rapidly progressed to her abdomen and upper extremities over the previous five days. Her medical history was remarkable for hypertension and diet-controlled diabetes mellitus. Her medications included enalapril, which she had been taking for the past four years. On three consecutive days before the skin eruption, the patient took oral diclofenac sodium for hip pain. A clinical examination revealed non-blanching petechial rash on the legs, abdomen, and upper limbs up to the elbow (Figure 1, A) with leukocytoclastic vasculitis on biopsy (Figure 1, B). Direct immunofluorescence was negative. Laboratory investigations revealed a white blood cell count of 14.5 × 109/L with a normal differential count, and a platelet count of 380 × 109/L. Westergren erythrocyte sedimentation rate was 65 mm/1st h, and C reactive protein was at 8.5 mg/dL. Antinuclear antibodies, rheumatoid factor, immune complexes, and cryoglobulinemia were negative, as were B and C hepatitis virus serological tests. Her renal

  18. Valorisation de chaleur à bas niveau thermique Upgrading Low-Thermal-Level Heat

    Directory of Open Access Journals (Sweden)

    Cohen G.

    2006-11-01

    Full Text Available La mise en oeuvre à la fois de cycles thermodynamiques et de fluides adaptés permet d'élargir considérablement les possibilités de récupération et de valorisation de la chaleur à bas niveau contenue dans les rejets thermiques industriels, l'eau géothermale, le rayonnement solaire ou le milieu environnant. Ceci permettra une meilleure préservation des ressources énergétiques dans les principaux secteurs consommateurs d'énergie : résidentiel, tertiaire et industriel. On décrit les possibilités que présentent : - Les cycles thermodynamiques directs (pompes de chaleur à compression ou à absorption dans le domaine du chauffage résidentiel et tertiaire où elles sont déjà bien implantées et dont les applications commencent à pénétrer le secteur industriel. - Les cycles thermodynamiques inverses (thermotransformateurs et cycles moteurs à fluide organique pour lesquels les progrès techniques accomplis et l'accroissement du prix de l'énergie devraient permettre d'en assurer la diffusion progressive dans le secteur industriel. The implementation of both thermodynamic cycles and suitable fluids makes for a considerable widening of the capacity to recover and upgrade the low-level heat contained in industrial heat wastes, geothermal water, solar radiation or the surrounding environment. This will make for better conservation of energy resources in the leading sectors of energy consumption, i. e. residential, tertiary and industrial. This article describes these possibilities in the form of: (a Direct thermodynamic cycles (compression or absorption heat pumps in the field of home and tertiary heating where they have already obtained a solid foothold and for which applications are beginning te penetrate into the industrial sector. (b Reverse thermodynamic cycles (heat transformers and organic-fluid motor cycles for which the technical advances made and the increase in energy prices should enable them to spread progressively

  19. Mohs micrographic surgery of rare cutaneous tumours

    NARCIS (Netherlands)

    Flohil, S.C.; Lee, C.B. van; Beisenherz, J.; Mureau, M.A.M.; Overbeek, L.I.H.; Nijsten, T.; Bos, R.R.

    2017-01-01

    BACKGROUND: Recurrence rates after Mohs micrographic surgery (MMS) for rare cutaneous tumours are poorly defined. OBJECTIVE: To investigate the recurrence rate after MMS for rare cutaneous tumours at a university centre. METHODS & MATERIALS: Retrospective review of all rare cutaneous tumours treated

  20. Lumbar lipomeningomyelocele associated with multiple café au lait spots: a case report.

    Science.gov (United States)

    Balasubramanian, Pradeep; Srinivas, C R; Arunachalam, Pavai; Thirumurthy, K S; Rajkumar, P R; Manuvidhya, H

    2015-01-01

    We report on a child with several café au lait spots in association with a lumbar lipomeningomyelocele as an apparently new association. Cutaneous markers, the identification of which plays a crucial role in the early diagnosis and management of spinal malformations, can accompany occult spinal dysraphism. Herein we report a case of lumbar lipomeningomyelocele associated with an overlying café au lait spot that served as a marker of occult spinal dysraphism. The patient also had segmental café au lait spots on the face, making the association unique. © 2015 Wiley Periodicals, Inc.

  1. Le long parcours du partenariat en employabilité au Québec

    Directory of Open Access Journals (Sweden)

    Martin Robitaille

    2005-07-01

    Full Text Available Ce texte a comme objectif de montrer comment des modifications au niveau des politiques d’emploi de même que les changements structurels et organisationnels apportés à l’offre publique des services d’emploi ont contribué à modifier la dynamique de partenariat et les conditions d’exercice du partenariat entre l’État et les organismes d’employabilité et d’insertion au Québec. L’évolution du partenariat dans ce domaine connaît de fortes perturbations parce que confrontée à deux logiques qui parviennent difficilement à cohabiter : une logique technocratique et instrumentale soutenue par l’État québécois et une logique de solidarité appuyée par les organismes communautaires qui offre des services en emploi pour le compte d’Emploi-Québec.

  2. Hyaline fibromatosis syndrome: cutaneous manifestations*

    Science.gov (United States)

    Marques, Silvio Alencar; Stolf, Hamilton Ometto; Polizel, Juliana Ocanha; Munhoz, Tânia; Brandão, Marcela Calixto; Marques, Mariangela Esther Alencar

    2016-01-01

    Hyaline fibromatosis syndrome is the current name for clinical manifestations of diseases previously known as “infantile systemic hyalinosis” and “juvenile hyaline fibromatosis”. The authors report representative clinical cases of each one of the above subtypes with emphasis on cutaneous manifestations and difficulties for early diagnosis in this syndrome, essentially of multidisciplinary approach. PMID:27192526

  3. [Histopathology of cutaneous drug reactions].

    Science.gov (United States)

    Ortonne, Nicolas

    2018-02-01

    There are many different types of cutaneous adverse reactions. The most classical reactions are driven by T lymphocytes that specifically react towards a drug, with an individual genetic susceptibility linked to certain type I major histocompatibility complex alleles. These reactions are characterized by a wide variety of clinical and histopathological presentations, and a wide range of severity. The most frequent entity is the maculopapular rash, while the most aggressive forms are the Steven-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN). The histopathological alterations associated to each of these syndromes have been better described in the literature during the past 10 years, encompassing non-specific lesions, as in most drug induced maculopapular rashes, to more specific inflammatory patterns. The finding of confluent apoptotic keratinocytes with epidermal detachment is the prototypical aspect of SJS-TEN. There are however numerous pitfalls, and a similar aspect to those observed in each cutaneous drug reactions entities can be found in other diseases. DRESS syndrome can indeed present with dense and epidermotropic T-cell infiltrate, sometimes with nuclear atypias, and thus can be difficult to distinguish from a primary or secondary cutaneous T-cell lymphoma. The diagnosis of cutaneous adverse reactions relies on a clinical-pathological confrontation and requires an accurate evaluation of drug imputability. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  4. Ultraviolet light and cutaneous lupus

    NARCIS (Netherlands)

    Bijl, Marc; Kallenberg, Cees G. M.

    2006-01-01

    Exposure to ultraviolet (UV) light is one of the major factors known to trigger cutaneous disease activity in (systemic) lupus erythematosus patients. UV light, UVB in particular, is a potent inducer of apoptosis. Currently, disturbed clearance of apoptotic cells is one of the concepts explaining

  5. Sporotrichoid pattern of cutaneous nocardiosis

    Directory of Open Access Journals (Sweden)

    Inamadar A

    2003-01-01

    Full Text Available A young male patient, having linearly arranged nodular lesions on lower extremity was diagnosed to have lymphocutaneous variety of cutaneous nocardiosis. This is a rare entity and has to be differentiated form other causes of nodular lymphangitis. The patient responded dramatically to Cotrimoxazole therapy.

  6. Le Groupement Villageois : un cadre de participation communautaire au développement ou un instrument de réalisation d'intérêts individuels et conflictuels

    OpenAIRE

    Tossou, Rigobert Cocou

    2008-01-01

    Le développement de l'agriculture vivrière et industrielle a connu une sérieuse stagnation ces deux dernières décennies en Afrique subsaharienne. Les projets de développement rural sont de plus en plus mis en cause aussi bien au niveau des objectifs qu'ils se fixent qu'au niveau de leurs méthodes d'intervention. Tous les développeurs deviennent de plus en plus conscients que la clef du problème est toute entière entre les mains des paysans. Ainsi, ils cherchent les voies et moyens pour identi...

  7. Génération automatique de contrôleur reprogrammable dans un environnement de synthèse de haut niveau

    OpenAIRE

    Benmohammed, M.; Kission, P.; Jerraya, A.A.

    1996-01-01

    Ce papier traite de la synthèse automatique d'un contrôleur reprogrammable dans un environnement de synthèse de haut niveau. Partant d'une spécification comportementale de haut niveau décrivant la fonction du circuit, la synthèse de haut niveau fournit une architecture composée d'un chemin de données et d'un contrôleur. L'architecture générée est flexible du fait de l'utilisation d'un contrôleur à la base d'une ROM et d'un séquenceur figé. L'avantage d'utiliser un contrôleur reprogrammable es...

  8. De l’inscription à un MOOC à la certification académique : le cas de la collection de MOOC « compétences du numérique et C2i Niveau 1 »

    Directory of Open Access Journals (Sweden)

    Bertrand Mocquet

    2016-01-01

    Full Text Available Dans le présent article, nous montrons comment a été standardisé un dispositif de formation à distance interuniversitaire par collection de MOOC (Massive Open Online Course, qui amène à une certification académique. Nous présentons d’abord la mise en oeuvre et l’évaluation d’un dispositif de formation : la collection de MOOC en compétences du numérique sur la plateforme nationale FUN (France Université Numérique. Puis, nous décrivons la mise en oeuvre du processus de certification permettant aux inscrits au MOOC de passer la certification C2i1 (Certificat Informatique et Internet niveau 1 académique délivrée par les universités françaises. Cette approche a été accompagnée expérimentalement et les résultats obtenus ont montré la possibilité de créer des parcours amenant à la délivrance de véritables certifications reconnues académiquement pour un public non étudiant.

  9. La structure sociale de l’industrie des Biotechnologies en France: une étude des relations inter-organisationnelles au niveau inter-individuel.

    Directory of Open Access Journals (Sweden)

    Piña-Stranger, Alvaro

    2010-06-01

    Full Text Available Various authors have shown the importance of collaborative relationships for inter-organizational performance, the mode of governance or the trajectory of biotechnology companies. Most of these works analyze the exclusive contractual agreements between companies and their main relationships among individuals. We show that this purely economic approach presents a major limitation: the nature of contractual relationships does not explore in detail how players cooperate. We propose to extend the study of these inter-organizational social relations, seen through the resource exchange in inter-individual. An empirical study on the leaders of the biotechnology industry in the area of human health in France has allowed us to map their relationships and resources they exchange them. Our results confirm the existence of a system of exchange dense and multiple. It presents a hierarchical distribution of various types of resources, where the centre is different from the periphery relations denser, more numerous and more reciprocal. However, comparative analysis of different networks reveals that the relationships of the board are highly centralized, while those of friendship following a more even distribution. We suggest that this phenomenon is part of a compensation mechanism to less central actors to maintain inter-organizational relationships. Finally, two standards of the cooperation process, revealed by the relational behaviour of actors, have been discovered. We suggest that they reflect in part the difficult process of adjustment that must cross a science project out of the realm of academic research and develop in a private structure: the biotech company.

  10. Survey: Knowledge level of the population about radon in Switzerland; Enquete: niveau de connaissance de la population au sujet du radon en Suisse

    Energy Technology Data Exchange (ETDEWEB)

    Gruson, M.; Murith, C. [Office Federal de la Sante Publique, Section Risques Radiologiques, Berne (Switzerland); Rumo, S. [CBC Marketing Research, Berne (Switzerland)

    2010-01-15

    In 1995, a survey was conducted in order to investigate levels of knowledge about radon among the Swiss population. In 2008, a second survey, using a similar methodology, was carried out by the F.O.P.H.. The new study showed that about 40% of the Swiss population has heard of radon, which represents an increase of 8% over the 1995 survey. Most of the respondents knew that radon causes lung cancer, but believed that the gas also produces other health effects (in particular, migraine and skin conditions). In addition, older people, those with a high level of education and property owners tended to be more familiar with the radon issue than the public at large. The inhabitants of high-risk regions achieved markedly better results, which demonstrate that information campaigns in these regions have been successful. At the same time, additional communication efforts are required in low- and medium-risk municipalities, where the majority of the population lives. (authors)

  11. Génération et évaluation de mécanismes de détection des intrusions au niveau applicatif

    OpenAIRE

    Demay, Jonathan-Christofer

    2011-01-01

    The most common anomaly detection mechanisms at application level consists in detecting a deviation of the control-flow of a program. A popular method to detect such anomaly is the use of application sequences of system calls. However, such methods do not detect mimicry attacks or attacks against the integrity of the system call parameters. These kinds of attacks can be achieved by targeting non-control-data items used by the process. To enhance such detection mechanisms, we propose an approa...

  12. L'impact du miellat de puceron au niveau des relations tritrophiques entre les plantes-hôtes, les insectes ravageurs et leurs ennemis naturels

    Directory of Open Access Journals (Sweden)

    Leroy P.

    2009-01-01

    Full Text Available Aphid honeydew impact on the tritrophic relationships between host-plants, phytophagous insects and their natural enemies. Tritrophic relations between plants, phytophagous insects and beneficials are based on the presence of chemical cues in the environment. In this context, honeydew (the aphid excretory product, rich in sugars and amino-acids, constitutes a nutritional resource for beneficials but also acts as a volatile and a contact kairomone. On one hand, honeydew volatile chemicals cues guide beneficials to a food source, hosts or preys but also stimulate particular behaviors: searching, preys/hosts locations and attacks. On the other hand, a contact with honeydew induces the oviposition especially for syrphids (Episyrphus balteatus, etc.. The use of an artificial honeydew could be a way for enhancing the biological control efficiency in fields by increasing the number of beneficials but also the predation and parasitic rates.

  13. Contribution à l'étude du traitement des erreurs au niveau lexico-syntaxique dans un texte écrit en français

    OpenAIRE

    Strube Den Lima, Vare Lucia

    1990-01-01

    Cette thèse aborde le thème du traitement des erreurs aux niveaux lexical et syntaxique dans un texte écrit en français. Nous présentons d'abord une approche générale des erreurs pouvant apparaitre dans un texte. Nous donnons les éléments de base d'un ensemble de méthodes utilisées actuellement dans le traitement d'erreurs aux niveaux lexical et syntaxique et décrivons des méthodes de correction proposées dans les principales études réalisées dans le domaine de la correction. Après une brève ...

  14. Determination du niveau d'anticorps antitetaniques en donneurs de sang au moyen du test ELISA-TÉTANOS (São Paulo, SP, Bresil

    Directory of Open Access Journals (Sweden)

    Luzia Cristina Contim Ferrato

    1990-12-01

    Full Text Available Le test ELISA-TÉTANOS (Biosys, France a été utilisé pour le titrage des anti-corps tétaniques (sensibilité = 0,0025 UI/ml en sérums humains de donneurs de sang, 566 hommes et 108 femmes, âges de 18 à 58 ans, moyenne de 29 ans, provenant de São Paulo, SP, Brésil. L'OMS, acceptant seulement la séroneutralisation sur souris (NT, la méthode de référence, pour les études sur la protection contre le tétanos, préconise le titre de 0,01 UI/ml comme minimum protecteur. BOURLEAUD & HUET ont proposé la limite de 0,06 UI/ml quand s'emploie le test ELISA, en attendant à une certaine discordance inévitable entre les méthodes. Parmi les 674 sérums étudiés, 178 (26,41% n'ont pas présenté d'anticorps ( 0,06 UI/ml.

  15. De la pratique des textes non litteraires au Niveau 2 (Redarding the Use of Non-Literary Materials on an Advanced Level).

    Science.gov (United States)

    Besse, Henri

    1980-01-01

    Discusses the notion of "authentic materials" (i.e., not designed for pedagogical use) and the problems of using them in a French-as-a-second-language classroom. Methods for using these materials are suggested. (AM)

  16. Mechanisms and manifestations of toxic actions at the bone tissue level; Mecanismes et manifestations de l'action des toxiques au niveau du tissu osseux

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-07-01

    The principal abnormalities determined by toxic at the bone level are: osteoporosis, osteomalacia, osteosclerosis or osteopetrosis. The principal toxics having a noxiousness at the bone level are: the fluorine, the phosphorus, the lead, the bismuth, the cadmium and the strontium. The strontium 90 has an important radioactivity that gives at the bone level osteosarcomas or at low doses, leukemoid reactions and marrow angiosarcoma. (N.C.)

  17. Freins et leviers à la diversification des cultures : étude au niveau des exploitations agricoles et des filières

    Directory of Open Access Journals (Sweden)

    Meynard Jean-Marc

    2013-07-01

    Full Text Available La diversification des cultures est souvent présentée comme un levier d’action pour accroître la durabilité des systèmes de production agricoles. Bien raisonnée, elle favorise en effet une réduction de l’usage d’intrants extérieurs à l’exploitation – pesticides, engrais, eau – et des nuisances environnementales associées à leur utilisation excessive. À l’inverse, la simplification des systèmes de culture engagée depuis plus de 40 ans s’est accompagnée d’un recours croissant aux intrants. Cependant, malgré son intérêt pour les systèmes de production en termes de durabilité écologique mais aussi économique (répartition des risques, et son inscription dans divers plans et dispositifs incitatifs, la diversification des cultures progresse peu. Les ministères en charge de l’agriculture et de l’environnement ont donc commandé à l’INRA une étude visant à identifier les freins à la diversification des cultures en France et les leviers mobilisables, par les pouvoirs publics notamment, pour la favoriser. L’hypothèse de travail est que ces freins relèvent du fonctionnement global du système agro-industriel, et de la capacité de développement de filières valorisant les cultures de diversification. L’étude a examiné un certain nombre de cas représentatifs de la diversité des filières et notamment de leurs modes d’organisation, qui déterminent la coordination et l’engagement des acteurs économiques impliqués dans le développement d’une culture de diversification.

  18. Analyse biomécanique pour la compréhension et l’amélioration du fauteuil roulant dans son application au tennis de haut niveau

    OpenAIRE

    Bascou, Joseph

    2012-01-01

    The development of Paralympics has done a lot for a more positive image of handicap and has opened up new opportunities for the practice of disability sport, known to be highly beneficial for the physical and psychological health of disabled people. Conducted in close partnership with a high level tennis player, this study focuses on the influence of the wheelchair settings on its behavior in order to adapt this behavior to wheelchair tennis playing. The study first highlighted the forces of ...

  19. L'Apprentissage des Langues au Niveau Debutant: Le Probleme des Supports Ecrits (Second Language Learning at the Elementary Level: The Problem of Writing). Melanges Pedagogiques, 1976

    Science.gov (United States)

    Cembalo, M.; And Others

    The experiment reported on in this article is an attempt to cope satisfactorily with the problem of introducing writing in an elementary second language course. In the beginners' course set up at the C.R.A.P.E.L., the decision was made not to "introduce" the written language but to enable the learners, from the beginning of the course, to write…

  20. Initiation vivante a l'apprentissage d'une langue au niveau primaire (A Lively Introduction to the Learning of a Foreign Language in Primary Grades)

    Science.gov (United States)

    Marion, Yolande

    1977-01-01

    Learning a language is an "attitude"; particularly in the primary grades, the teacher must use the procedures and materials best suited to develop a favorable attitude, provide enjoyment, stimulate curiosity, promote acquisition of linguistic and communication skills. Skits, songs, games and audio-visual techniques are suggested. (Text is in…

  1. Aspects motivationnels de l'apprentissage de l'espagnol au niveau universitaire (Motivational Aspects of University Level Spanish Language Learning).

    Science.gov (United States)

    Moise, Lena Celine; And Others

    1990-01-01

    A study compared students' orientations toward learning Spanish to their orientations toward learning English or French as a second language, and examined other variables, including interethnic attitudes and contact, motivation, self-confidence, and Spanish competence. Results do not permit a clear delineation of a sociomotivational basis for…

  2. La comprehension du francais parle au niveau avance: un exemple de test (Comprehension of Spoken French at the Advanced Level: A Test Sample).

    Science.gov (United States)

    Mauriac, Paul

    1980-01-01

    The use of taped radio programs is suggested for testing advanced level French comprehension. In the testing technique described less attention is given to program content than to style and language usage. A sample test is presented. (MSE)

  3. [Cutaneous ultrasound and dermal fillers].

    Science.gov (United States)

    Villegas Fernández, C; Burón Álvarez, I; Fernández-Tresguerres Centeno, A; Alfageme Roldán, F; de Cabo Francés, F

    2015-11-01

    Requests for fillers or dermatological implants have dramatically increased in dermatology consultations in the last few years, either for the correction of superficial age-related wrinkles and cutaneous creases or to increase the volume of specific areas (cheeks, lips...). Dermatologists are often the first professionals to provide these treatments. Nevertheless, in other situations, the patients have already been treated, and many of them do not know the type of material that has been implanted or may even deny previous treatment, even when evident on clinical examination. In these occasions, cutaneous ultrasound is an effective and reliable tool for the real-time diagnosis of the kind of implant that has been used, its location, and the study of its possible complications. Copyright © 2015 Academia Española de Dermatología y Venereología. Published by Elsevier España, S.L.U. All rights reserved.

  4. Biology of Human Cutaneous Melanoma

    Directory of Open Access Journals (Sweden)

    Bhuvnesh K. Sharma

    2010-03-01

    Full Text Available A review of the natural behavior of cutaneous melanoma, clinical and pathological factors, prognostic indicators, some basic research and the present and possible futuristic strategies in the management of this disease are presented. While surgery remains to be the most effective therapeutic approach in the management of early primary lesions, there is no standard adjuvant therapy after surgical resection, or for metastatic disease.

  5. [Cutaneous leishmaniases in French Guiana].

    Science.gov (United States)

    Rotureau, B; Couppié, P; Nacher, M; Dedet, J P; Carme, B

    2007-10-01

    Cutaneous leishmaniases are endemic over the entire territory of French Guiana. At least 5 distinct Leishmania species coexist in the sylvatic ecotopes of this French territory. The present paper checks the advances in the ecological research field during the past 5 years. The current epidemiological situation and trends are detailed successively Links between the recrudescence of leishmaniases and gold-mining are highlighted. The potential adaptation of the pathogenic complexes to the newly anthropized habitats is also described.

  6. Cutaneous and mucosal pain syndromes

    Directory of Open Access Journals (Sweden)

    Siddappa K

    2002-01-01

    Full Text Available The cutaneous and mucosal pain syndromes are characterized by pain, burning sensation, numbness or paraesthesia of a particular part of the skin or mucosal surface without any visible signs. They are usually sensory disorders, sometimes with a great deal of psychologic overlay. In this article various conditions have been listed and are described. The possible causative mechanisms are discussed when they are applicable and the outline of their management is described.

  7. Cutaneous metastasis in anorectal adenocarcinoma

    Directory of Open Access Journals (Sweden)

    Krishnendra Varma

    2015-01-01

    Full Text Available Cutaneous metastasis in anorectal adenocarcinoma is a rare entity. Here, we report the case of a 40-year-old female who presented with yellowish-brown, irregular, solid, elevated rashes over the pubis with a recent history off palliative colostomy for anorectal adenocarcinoma. Clinically, we suspected metastasis that was proved on biopsy. We report this case due to the rare presenting site (i.e., perineum of a metastatic adenocarcinoma.

  8. Ampullary carcinoma with cutaneous metastasis

    Directory of Open Access Journals (Sweden)

    I-Ting Liu

    2016-06-01

    Full Text Available Carcinoma of the ampulla of Vater is a rare gastrointestinal tumor. Additionally, cutaneous metastasis from such an internal malignancy is also uncommon. We reported the case of a 55-year-old man afflicted with ampullary carcinoma with cutaneous metastasis. The patient did not undergo the standard Whipple procedure but received chemotherapy due to apparent left neck lymph node metastasis noted by initial PET/CT imaging. The skin metastasis presented as a left neck infiltrating purpuric lesion, which was confirmed by skin biopsy approximately one year after the patient's disease was first diagnosed. Thereafter, the patient received further chemotherapy pursuant to his course of medical management. Skin metastasis usually represents a poor patient prognosis. In these cases, treatment of cutaneous metastasis typically includes systemic chemotherapy and local management such as radiation therapy or tumor excision. And when choosing a chemotherapy regimen for the ampullary cancer, the histological subtypes (intestinal or pancreatobiliary should be comprehensively considered. In our review of the literature, the intestinal type seems to have less distant lymph node metastasis, advanced local invasion, as well as recurrence than pancreatobiliary type of ampullary cancer.

  9. Cutaneous Metastasis From Sacral Chordoma.

    Science.gov (United States)

    Gleghorn, Kristyna; Goodwin, Brandon; Sanchez, Ramon

    2017-04-01

    Chordoma is a rare primary bone malignancy of notochord origin, representing 1-4% of malignant bone tumors., Typically, chordomas follow a slow progressive course with aggressive local extension, multiple recurrences, and metastases. Of particular interest to this case, cutaneous metastasis is exceedingly rare. Diagnosis of this entity can be a challenge due to the rarity of chordoma, as well as the infrequent presentation of distant cutaneous metastasis and non-specific clinical skin findings. We report a case of a 61-year-old male with a history of sacral chordoma treated by wide local excision 8 years prior to presentation developed a nodule on his scalp for 6 weeks. Physical examination revealed a 1 cm rubbery, pink, shiny dome-shaped nodule on his left occipital scalp. Hematoxylin and eosin sections revealed a lobular dermal proliferation of small ovoid cells and larger physaliferous cells with hyperchromatic, displaced nuclei and finely vacuolated "soap-bubble" cytoplasm in a myxoid stroma. Immunohistochemistry of tumor cells showed positivity for both S-100 protein and pancytokeratin (AE1/AE3), while smooth muscle actin (SMA), P63, and CK7 were negative. Additionally, tumor cells stained positive for brachyury. The medical history, clinical presentation, histopathological appearance and immunohistochemical profile are consistent with cutaneous metastasis from sacral chordoma, known as chordoma cutis. This case illustrates the integral role of dermatopathology in the diagnosis of a rare and critical condition.

  10. Cutaneous Chromatophoromas in Captive Snakes.

    Science.gov (United States)

    Muñoz-Gutiérrez, J F; Garner, M M; Kiupel, M

    2016-11-01

    Chromatophoromas are neoplasms arising from pigment-bearing cells (chromatophores) of the dermis. While isolated cases have been reported in the literature, the prevalence and biological behavior of chromatophoromas in snakes are unknown. Forty-two chromatophoromas were identified among 4663 submissions (0.9%) to a private diagnostic laboratory in a 16-year period. The most commonly affected snakes were colubrids (23 cases, 55%) and vipers (8 cases, 19%). The San Francisco garter snake was the most commonly affected species (6 cases; 14% of all affected snake species and 3.7% of all garter snake submissions). No sex predilection was found. The age of 28 snakes ranged from 5 to 27 years. Single cutaneous chromatophoromas were most commonly observed and presented as pigmented cutaneous masses or plaques along any body segment. Euthanasia or death due to progressive neoplastic disease or metastasis was reported in 8 (19%) and 4 (10%) cases, respectively. The survival time of 4 animals ranged from 4 to 36 months. Microscopically, xanthophoromas, iridophoromas, melanocytic neoplasms, and mixed chromatophoromas were identified, with melanocytic neoplasms being most common. Microscopic examination alone was generally sufficient for the diagnosis of chromatophoroma, but immunohistochemistry for S-100 and PNL-2 may be helpful for diagnosing poorly pigmented cases. Moderate to marked nuclear atypia appears to be consistently present in cutaneous chromatophoromas with a high risk of metastasis, while mitotic count, lymphatic invasion, the level of infiltration, and the degree of pigmentation or ulceration were not reliable predictors of metastasis. © The Author(s) 2016.

  11. The diagnostic and clinical significance of café-au-lait macules.

    Science.gov (United States)

    Shah, Kara N

    2010-10-01

    Café-au-lait, also referred to as café-au-lait spots or café-au-lait macules, present as well-circumscribed, evenly pigmented macules and patches that range in size from 1 to 2 mm to greater than 20 cm in greatest diameter. Café-au-lait are common in children. Although most café-au-lait present as 1 or 2 spots in an otherwise healthy child, the presence of multiple café-au-lait, large segmental café-au-lait, associated facial dysmorphism, other cutaneous anomalies, or unusual findings on physical examination should suggest the possibility of an associated syndrome. While neurofibromatosis type 1 is the most common syndrome seen in children with multiple café-au-lait, other syndromes associated with one or more café-au-lait include McCune-Albright syndrome, Legius syndrome, Noonan syndrome and other neuro-cardio-facialcutaneous syndromes, ring chromosome syndromes, and constitutional mismatch repair deficiency syndrome. Copyright © 2010 Elsevier Inc. All rights reserved.

  12. AU BURKINA FASO

    African Journals Online (AJOL)

    Les moyennes sur la même ligne et possédant le même indice ne diffèrent pas significativement au seuil de 5 %. ME : mélange fourrager. 10-20-30 % : pourcentage de concentré. GMQ : Gain Moyen Quotidien. L'analyse des résultats des rations. 1 et 2 montre que l'accès au pâturage permet des performances supérieures.

  13. Evaluation of cutaneous palpebral anthrax.

    Science.gov (United States)

    Tekin, Recep; Ari, Seyhmus; Dal, Tuba; Kaya, Safak; Kortak, Mehmet Zeki; Dursun, Birgül; Dayan, Saim

    2013-10-01

    Anthrax is a rare disease caused by Bacillus anthracis. Antrax is zoonotic disease and is often encountered in persons engaged in animal husbandry. Cutaneous anthrax is approximately 95% of anthrax in humans. Palbebral involvement is rare. In this study, we aimed to evaluate the clinical presentation, diagnosis and treatment of cases with cutaneous palpebral anthrax. In this study, the patients diagnosed of cutaneous palpebral anthrax between January 2000 and December 2012, were investigated and evaluated, retrospectively. Cutaneous palpebral anthrax was diagnosed by the presence of typical anthrax lesion and/or observation of gram-positive encapsulated bacilli in gram prepations and/or culture positive of samples taken from lesions. In the cases who were culture-negative and without bacilli in gram-staining, the diagnosis was based on the presence of characteristic clinical presentation with a history of severe scarring formation, swelling, black eschar and positive response to the treatment. A total of 21 patients with cutaneous palpebral anthrax admitted to the two hospitals between January 2000 and December 2012. Eight patients were male (38.1%) and 13 patients were female (61.9%), and the mean age was 31 ± 21.2 (range 1-82 years). The most common symptoms on admission to the hospital were swelling and redness on the skin. Periorbital lesions were in the right eye in 14 cases and the most common eyelid involvement was seen in upper eyelid with 15 cases. The diagnosis was based on isolation of bacteria in five (23.8%) cases, detection of gram-positive bacilli in direct examination of characteristic lesion material in six (28.5%) cases. Ten (47.7%) cases were diagnosed by the characteristic appearance of the lesion. Malignant pustule was seen in all of our patients and seven cases (33.4%) had malignant edema. In the treatment, penicilin was used for 10 (47.7%) cases, ampicillin-sulbactam for five (23.8%) cases and, ciprofloxacin for three (14.3%) cases

  14. Etude par Imagerie à faible Niveau dans le proche Infrarouge d'une Emission de la haute Atmosphère

    Science.gov (United States)

    Pautet, Pierre-Dominique

    2000-12-01

    Le travail effectué a eu pour but la mise en place d'un protocole d'observation et de traitement des images, ainsi que les outils appropriés, visant à l'étude d'une émission de la haute atmosphère terrestre dans le proche infrarouge. Il existe actuellement des télescopes comme le VLT (Very Large Telescope), installé au Chili, qui permettent d'observer des astres et des galaxies distants de plusieurs millions de parsecs. A cause de l'expansion de l'Univers, des objets situés aussi loin s'éloignent très rapidement de nous. Le spectre de leur émission qui nous parvient alors est décalé vers le rouge ou l'infrarouge, du fait de l'effet Doppler. Il faut donc observer ces objets dans des longueurs d'onde appropriées. Malheureusement, l'atmosphère terrestre qui nous sépare d'eux est aussi le siège de nombreuses émissions qui peuvent venir perturber les mesures. De toutes ces émissions, la principale est due au radical OH dont les raies de rotation-vibration couvrent tout le spectre entre 0,7 et 2,5 microns. Cette émission a lieu au niveau d'une couche assez fine de la haute atmosphère appelée mésopause et située à environ 85 kilomètres d'altitude. Le travail effectué a eu pour but de mettre en évidence les principales caractéristiques de cette émission qui n'est pas uniforme et constante dans le temps. Un programme d'observations dans le proche infrarouge a été élaboré. Plusieurs algorithmes de traitement d'image ont été développés. Un programme d'inversion de perspective a été mis au point pour une utilisation en temps réel sur le terrain. Les caractéristiques des images peuvent être ensuite analysées. La première partie du mémoire comporte une description des différentes émissions lumineuses que l'on peut observer la nuit lorsque l'on regarde la voûte céleste. Ces émissions peuvent avoir deux origines: astronomique ou atmosphérique. Le problème de l'absorption atmosphérique et plus précisément les conditions

  15. [Evaluation of Cutaneous Microcirculation at the Dorsum of the Hand within Different Age Groups - Implications for Wound Healing in Hand Surgery?].

    Science.gov (United States)

    Forstmeier, V; Sorg, H; Kabbani, M; Herold, C; Altintas, M A; Krämer, R

    2015-12-01

    Cutaneous microcirculation has shown to play a key role in wound healing. Although healing disorders are still one of the most common complications in hand surgery, there still exists a lack of scientific research on possible age-related changes in cutaneous microcirculation at the dorsum of hand. Cutaneous microcirculation at the dorsum of the hand differs significantly between different age groups. 53 healthy subjects were divided into 2 groups by age (Group A:Group B≥40 years, n=22). All subjects underwent measurement of the microcirculation at the dorsum of the hand with combined laser-Doppler and photo spectrometry. Cutaneous oxygen saturation was significantly higher in Group A than in Group B (A: 64.7±9.9% vs. B: 58.3±12.6%; p=0,044). In contrast, blood flow velocity was significantly higher in Group B (A: 43±19.6 AU vs. B: 56.7±21.1 AU; p=0.019). The hypothesis of this study was confirmed. This is the first study to show significant differences of cutaneous microcirculation at the dorsum of the hand within different age groups. Further clinical trials are needed in order to examine if delayed wound healing can be correlated to impaired cutaneous microcirculation at the dorsum of the hand. © Georg Thieme Verlag KG Stuttgart · New York.

  16. Cutaneous manifestations in patients with mastocytosis

    DEFF Research Database (Denmark)

    Hartmann, Karin; Escribano, Luis; Grattan, Clive

    2016-01-01

    Cutaneous lesions in patients with mastocytosis are highly heterogeneous and encompass localized and disseminated forms. Although a classification and criteria for cutaneous mastocytosis (CM) have been proposed, there remains a need to better define subforms of cutaneous manifestations in patients...... times between 2010 and 2014 to discuss the classification and criteria for diagnosis of cutaneous manifestations in patients with mastocytosis. This article provides the major outcomes of these meetings and a proposal for a revised definition and criteria. In particular, we recommend that the typical...

  17. Dans quelle mesure les conflits interpersonnels se produisant au sein d’une équipe de travail, peuvent-ils constituer une cause de l’épuisement professionnel?

    OpenAIRE

    Dachelet, Claire

    2017-01-01

    La première partie de ce travail concerne les processus de conflits interpersonnels au sein des équipes de travail. Tout d'abord, les différents types de conflits et leurs antécédents seront étudiés. Ensuite, le point sera fait concernant les conséquences probables de ces conflits; aussi bien au niveau des performances que du bien-être de l’individu. Pour finir cette partie, différentes variables modératrices seront passées en revue, celles-ci impacteront le lien entre le conflit et ses consé...

  18. Many faces of cutaneous leishmaniasis

    Directory of Open Access Journals (Sweden)

    Bari Arfan Ul

    2008-01-01

    Full Text Available Background: Cutaneous leishmaniasis (CL is known for its clinical diversity and increasing numbers of new and rare variants of the disease are being reported these days. Aim: The aim of this descriptive study was to look for and report the atypical presentations of this common disease occurring in Pakistan. Methods: The study was carried out in three hospitals (MH, Rawalpindi; PAF Hospital, Sargodha; and CMH, Muzaffarabad from 2002 to 2006. Military and civilian patients of all ages, both males and females, belonging to central and north Punjab province and Kashmir were included in the study. Clinical as well as parasitological features of cutaneous leishmaniasis were studied. The unusual lesions were photographed and categorized accordingly using simple descriptive statistics. Results: Out of 718 patients of cutaneous leishmaniasis, 41 (5.7% had unusual presentations. The commonest among unusual morphologies was lupoid leishmaniasis 14 (34.1%, followed by sporotrichoid 5 (12.1%, paronychial 3 (7.3%, lid leishmaniasis 2 (4.9%, psoriasiform 2 (4.9%, mycetoma-like 2 (4.9%, erysipeloid 2 (4.9%, chancriform 2 (4.9%, whitlow 1 (2.4%, scar leishmaniasis 1 (2.4%, DLE-like 1 (2.4%, ′squamous cell carcinoma′-like 1 (2.4%, zosteriform 1 (2.4%, eczematous 1 (2.4%, verrucous 1 (2.4%, palmar/plantar 1 (2.4% and mucocutaneous 1 (2.4%. Conclusion: In Pakistan, an endemic country for CL, the possibility of CL should be kept in mind while diagnosing common dermatological diseases like erysipelas, chronic eczema, herpes zoster, paronychia; and uncommon disorders like lupus vulgaris, squamous cell carcinoma, sporotrichosis, mycetoma and other deep mycoses.

  19. Cutaneous lesions in new born

    Directory of Open Access Journals (Sweden)

    Sachdeva Meenakshi

    2002-11-01

    Full Text Available Five hundred unselected newborn babies delivered in the Department of Obstetrics and Gynaecology, Unit II of SGBT Hospital attached to Government Medical College, Amritsar during April 2000 to October 2000 were examined for cutaneous lesions daily for the first five days after birth. Different cutaneous lesions were seen in 474(94. 8% newborns. The physiological skin changes observed in order of frequency were Epstein pearls in 305(61%, Mongolian spot in 301(60. 2%, superficial cutaneous desquamation in 200(40%, icterus in 128(25. 6%, milia in 119(23. 8%, sebaceous gland hyperplasia in 107 (21. 4%, occipital alopecia in 94(18. 8%, lanugo in 72(14. 4%, peripheral cyanosis in 47(9. 4%, breast hypertrophy in 29(5. 8% and miniature puberty in 28(5. 6% newborns. Of the transient non-infective skin diseases, erythema toxicum neonatorum was observed most commonly in 105(21 %, followed by miliaria rubra in 103(20. 6% and acne neonatorum in 27(5. 4% newborns. The naevi and other developmental defects in the descending order were salmon patch in 69(13. 8%, congenital melanocytic noevi in 10(2%, accessory tragi in 3(0.6%, spina bifida in 2(0.4%, hydrocephalus in 1(0.2% and poliosis in 1(0.2% newborns. Cradle cap was the only dermatitis observed in 50(10% newborns. One (0.2% case each of Harlequin ichthyosis and labial cyst was seen.

  20. Cutaneous Leishmaniasis with Unusual Presentation

    Directory of Open Access Journals (Sweden)

    N Bagherani

    2009-05-01

    Full Text Available "nThis case report states a 25-year-old woman, residing in the city of Dezfool, Khuzestan Province, south of Iran with the diagnosis of cutaneous leishmaniasis in June 2008. Her skin lesion had de­veloped from 8 months earlier as a nodule on her left arm, 1×3 cm in diameter. Because of sever­ity of the lesion, we prescribed meglumine antimoniate intralesionally with giving up her breast feeding. After 6 months follow-up, no recurrence was seen.

  1. Cutaneous manifestations in leukemia patients.

    Science.gov (United States)

    Grunwald, Michael R; McDonnell, Megan H; Induru, Raghava; Gerber, Jonathan M

    2016-06-01

    Cutaneous complications are common in patients with leukemia. However, the cause is not always immediately clear, as there are often numerous potential etiologies. Thrombocytopenia or coagulopathy can result in ecchymoses or petechiae, whereas extramedullary (EM) involvement by leukemia can present as a rash. Leukemia can also result in skin manifestations via indirect means, including several types of paraneoplastic phenomena. Moreover, various agents routinely used to treat leukemia-most notably cytarabine (cytosine arabinoside)-can precipitate quite profound skin eruptions. Finally, infections, including fungal invasion of the skin, can be responsible for rashes, as can the vast array of antimicrobials that are administered to leukemia patients. Copyright © 2016. Published by Elsevier Inc.

  2. [Cutaneous manifestations of systemic mycoses].

    Science.gov (United States)

    Matsumoto, Tadahiko; Nishimoto, Katsutaro

    2003-01-01

    The systemic mycoses are increasing in importance as opportunistic infections. Cutaneous lesions resulting from systemic mycoses may first alert clinicians to the presence of a life-threatening disorder, or even the presence of an unsuspected immunodeficiency state. Skin involvement is generally uncommon in disseminated aspergillosis, zygomycosis but is more common in systemic candidiasis (candidemia) and cryptococcosis. The blanket terms, hyalohyphomycosis and phaeohyphomycosis, cover the infections caused by diverse fungal opportunists. A variety of manifestations of skin lesions of the systemic mycoses are reviewed. These specific and/or non-specific lesions require early recognition, diagnosis, and aggressive antifungal treatment.

  3. Chronic Cutaneous Draining Sinus of Dental Origin

    African Journals Online (AJOL)

    surgery. It can also result from infection or inflammation. The root canal of a necrotic tooth is a source of predominantly anaerobic microbes. The tooth may present without any symptoms, except a cutaneous draining sinus.[1] Due to the extra-oral location of the sinus, patients tend to seek medical care first. These cutaneous.

  4. Cutaneous sporotrichosis: Unusual clinical presentations

    Directory of Open Access Journals (Sweden)

    Mahajan Vikram

    2010-01-01

    Full Text Available Three unusual clinical forms of sporotrichosis described in this paper will be a primer for the clinicians for an early diagnosis and treatment, especially in its unusual presentations. Case 1, a 52-year-old man, developed sporotrichosis over pre-existing facial nodulo-ulcerative basal cell carcinoma of seven-year duration, due to its contamination perhaps from topical herbal pastes and lymphocutaneous sporotrichosis over right hand/forearm from facial lesion/herbal paste. Case 2, a 25-year-old woman, presented with disseminated systemic-cutaneous, osteoarticular and possibly pleural (effusion sporotrichosis. There was no laboratory evidence of tuberculosis and treatment with anti-tuberculosis drugs (ATT did not benefit. Both these cases were diagnosed by histopathology/culture of S. schenckii from tissue specimens. Case 3, a 20-year-old girl, had multiple intensely pruritic, nodular lesions over/around left knee of two-year duration. She was diagnosed clinically as a case of prurigo nodularis and histologically as cutaneous tuberculosis, albeit, other laboratory investigations and treatment with ATT did not support the diagnosis. All the three patients responded well to saturated solution of potassium iodide (SSKI therapy. A high clinical suspicion is important in early diagnosis and treatment to prevent chronicity and morbidity in these patients. SSKI is fairly safe and effective when itraconazole is not affordable/ available.

  5. [Diagnosis tools for cutaneous melanoma].

    Science.gov (United States)

    Guitera-Rovel, P; Vestergaard, M-E

    2008-12-01

    A number of new tools have been developed in the last ten years to improve the diagnosis of cutaneous melanoma. To review the value of diagnostic tools for cutaneous melanoma in a clinical setting. Review of multiple databases from 1987 to 2007 and classification of publications in terms of level of evidence according to "The Australian Cancer Network". Dermoscopy has superior specificity and sensitivity to naked-eye examination according to a meta-analysis of nine level-2 studies. Sequential digital dermoscopic imaging allowed detection of melanoma in the absence of dermoscopic evidence of melanoma in four level-2 studies. Total body photography, generally performed for high-risk patients, seems to be equally valuable but has the additional advantage of allowing self-examination by patients themselves. Dermographic photographs with computer-assisted diagnosis of primary melanoma appear to have equivalent diagnostic capacity to experts but very few studies have been performed in a clinical setting. Optical methods still under development yield in vivo information that is closely correlated with histopathology data and may avoid unnecessary excision while providing improved control of excision margins. They will doubtless be used as a second-line method after clinical detection of suspect lesions and history-taking, which will continue to be primordial regardless of the other tools available.

  6. Deep-seated segmental neurofibromatosis without café au lait spots.

    Science.gov (United States)

    Ogose, A; Hotta, T; Imaizumi, S; Saito, H; Homma, T; Takahashi, H E

    2000-09-01

    Segmental neurofibromatosis is a rare disease characterized by neurofibromas with or without café au lait spots localized to one segment of the body. The majority of reported cases have had cutaneous neurofibromas, and patients with deep involvement have rarely been described. We report on two patients with deep-seated segmental plexiform neurofibromatosis and review the literature. All reviewed cases including the present two had no café au lait spots, axillary freckling, Lisch nodules, family history or malignant progression of disease. Differential diagnoses from neuro-fibromatosis 1 (von Recklinghausen disease) and malignant peripheral nerve sheath tumor are important for genetic counseling and avoiding overtreatment.

  7. Les facteurs associés à l'infection au cours de la polyarthrite ...

    African Journals Online (AJOL)

    Les facteurs associés à l'infection au cours de la polyarthrite rhumatoïde. ... les infections urogénitales (22 cas), pleuro pulmonaires (11 cas) dont 2 cas de tuberculose pulmonaire et un cas d'infection H1N1, 3 cas d'infections cutanées et 4 cas d'arthrite septiques. ... particulière pour améliorer la qualité de prise en charge.

  8. Au pair trajectories

    DEFF Research Database (Denmark)

    Dalgas, Karina Märcher

    2015-01-01

    Since 2000, thousands of young Filipino migrants have come to Denmark as au pairs. Officially, they are there to “broaden their cultural horizons” by living temporarily with a Danish host family, but they also conduct domestic labor in exchange for food and money, which allows them to send...

  9. Catalytic activity of Au nanoparticles

    DEFF Research Database (Denmark)

    Larsen, Britt Hvolbæk; Janssens, Ton V.W.; Clausen, Bjerne

    2007-01-01

    Au is usually viewed as an inert metal, but surprisingly it has been found that Au nanoparticles less than 3–5 nm in diameter are catalytically active for several chemical reactions. We discuss the origin of this effect, focusing on the way in which the chemical activity of Au may change with par......Au is usually viewed as an inert metal, but surprisingly it has been found that Au nanoparticles less than 3–5 nm in diameter are catalytically active for several chemical reactions. We discuss the origin of this effect, focusing on the way in which the chemical activity of Au may change...... with particle size. We find that the fraction of low-coordinated Au atoms scales approximately with the catalytic activity, suggesting that atoms on the corners and edges of Au nanoparticles are the active sites. This effect is explained using density functional calculations....

  10. Grammaire progressive du français corrigés : niveau intermédiaire : avec 680 exercices

    CERN Document Server

    Thiévenaz, Odile

    2013-01-01

    Les corrigés de la 3e édition de la Grammaire progressive du français - niveau intermédiaire Ce qui fait le succès de cette grammaire : Une organisation claire : la leçon de grammaire sur la page de gauche ; les exercices d'entraînement sur la page de droite ; 52 chapitres présentant les points généralement abordés aux niveaux A2 et B1 du Cadre européen commun de référence pour les langues ; Un apprentissage progressif : il suit la progression naturelle des méthodes de français ; Un usage souple : pour la classe ou en auto-apprentissage ; Une préparation adaptée aux certifications : un entraînement efficace pour mieux réussir aux examens ; Une large place faite à l'évaluation : de nombreux exercices de révision et des bilans réguliers. À découvrir dans cette troisième édition tout en couleurs (ISBN 978 209 038 124 5) : Un CD audio avec 14 documents sonores ; 80 nouveaux exercices et activités communicatives ; Des chapitres révisés et des exercices plus variés ; Un test d'�...

  11. Les maisons bâties au village d’origine dans les représentations des migrants roumains

    Directory of Open Access Journals (Sweden)

    Andra Larionescu

    2013-06-01

    Full Text Available Les maisons des migrants bâties dans le pays d’origine revêtent de significations différentes: certains migrants les perçoivent comme un moyen de valider leur statut social au sein de la communauté d’origine, tandis que d’autres les conçoivent comme un investissement ou comme une « sécurité » à la retraite, ou bien comme un abri en cas d’échec. Néanmoins, pour la majorité des migrants, la maison reste un « chez soi» lié soit au pays d’origine, soit au pays de destination, le sentiment d’appartenance étant déterminé par l’âge du sujet, le gendre, le niveau d’éducation, les liens familiaux, l’expérience de la migration et les caractéristiques du marché du travail. En utilisant un travail de terrain mené entre 2009 et 2011 dans le village de Marginea, au nord de la Roumanie, l’article examine les facteurs qui influent sur la sémantique de la maison bâtie au village d’origine.

  12. Characterization of cutaneous and articular sensory neurons.

    Science.gov (United States)

    da Silva Serra, Ines; Husson, Zoé; Bartlett, Jonathan D; Smith, Ewan St John

    2016-01-01

    A wide range of stimuli can activate sensory neurons and neurons innervating specific tissues often have distinct properties. Here, we used retrograde tracing to identify sensory neurons innervating the hind paw skin (cutaneous) and ankle/knee joints (articular), and combined immunohistochemistry and electrophysiology analysis to determine the neurochemical phenotype of cutaneous and articular neurons, as well as their electrical and chemical excitability. Immunohistochemistry analysis using RetroBeads as a retrograde tracer confirmed previous data that cutaneous and articular neurons are a mixture of myelinated and unmyelinated neurons, and the majority of both populations are peptidergic. In whole-cell patch-clamp recordings from cultured dorsal root ganglion neurons, voltage-gated inward currents and action potential parameters were largely similar between articular and cutaneous neurons, although cutaneous neuron action potentials had a longer half-peak duration (HPD). An assessment of chemical sensitivity showed that all neurons responded to a pH 5.0 solution, but that acid-sensing ion channel (ASIC) currents, determined by inhibition with the nonselective acid-sensing ion channel antagonist benzamil, were of a greater magnitude in cutaneous compared to articular neurons. Forty to fifty percent of cutaneous and articular neurons responded to capsaicin, cinnamaldehyde, and menthol, indicating similar expression levels of transient receptor potential vanilloid 1 (TRPV1), transient receptor potential ankyrin 1 (TRPA1), and transient receptor potential melastatin 8 (TRPM8), respectively. By contrast, significantly more articular neurons responded to ATP than cutaneous neurons. This work makes a detailed characterization of cutaneous and articular sensory neurons and highlights the importance of making recordings from identified neuronal populations: sensory neurons innervating different tissues have subtly different properties, possibly reflecting different

  13. Technique du Micro-Enseignement: Une Approche Pour Enseigner La Pratique de La Lecture aux Apprenants de Niveau A2 et La Perception de Cette Technique Par Les Futurs Enseignants

    Directory of Open Access Journals (Sweden)

    Nurten ÖZÇELİK

    2017-09-01

    Full Text Available Cette étude a été préparée en vue de déterminer les difficultés rencontrées par les futurs enseignants lors de l’enseignement de la lecture aux apprenants de niveau A2 par la technique du micro-enseignement, et de mettre à jour leurs opinions concernant les avantages ainsi que les inconvénients de cette technique. Le groupe de travail est composé de 20 futurs enseignants (14 femmes, 6 hommes du Département de la Didactique du FLE de la Faculté Pédagogique de l’Université Gazi, pour le deuxième semestre de la période 2014-2015. Les données recueillies par les questions à réponses ouvertes ont été évaluées par la méthode de l’analyse descriptive, à la suite des calculs de fréquence. Selon les résultats obtenus, les futurs enseignants ont surtout du mal à prononcer le français, à gérer leurs émotions, à préparer une présentation, des activités de pré-lecture et du dossier de présentation. Augmenter la confiance en soi, apprendre à préparer un plan de cours, donner la possibilité de voir les aspects insuffisants sont les points positifs de la technique. L’insuffisance des participations au cours, l’artificialité du milieu de la classe, la subjectivité des critiques des pairs sont indiqués par les participants comme les inconvénients de cette technique.

  14. Cutaneous Manifestations in Inflammatory Bowel Diseases

    Directory of Open Access Journals (Sweden)

    Simona Roxana Georgescu

    2015-10-01

    Full Text Available Inflammatory bowel diseases have a high frequency in Europe. They are chronic disorders that evolve with relapses and remissions. Clinical features include the signs of underlying inflammatory bowel disease and also signs of extraintestinal manifestations. Cutaneous disorders are the most common extraintestinal manifestations associated with inflammatory bowel diseases, which can be dependent on or independent of gastrointestinal disease activity. The main cutaneous disorders are erythema nodosum and pyodermagangrenosum. The pathogenic mechanisms are not fully understood but it seems that related mechanisms are involved in the development of inflammatory bowel diseases and extraintestinal manifestations. Treatment should be aimed at both the cutaneous manifestations and the bowel inflammation

  15. Cutaneous findings in five cases of malaria

    Directory of Open Access Journals (Sweden)

    Jignesh B Vaishnani

    2011-01-01

    Full Text Available Malaria is an infectious disease caused by protozoa of the genus Plasmodium. Cutaneous lesions in malaria are rarely reported and include urticaria, angioedema, petechiae, purpura, and disseminated intravascular coagulation (DIC. Here, five malaria cases associated with cutaneous lesions have been described. Out of the five cases of malaria, two were associated with urticaria and angioedema, one case was associated with urticaria, and other two were associated with reticulated blotchy erythema with petechiae. Most of the cutaneous lesions in malaria were nonspecific and reflected the different immunopathological mechanism in malarial infection.

  16. Cutaneous Scarring: A Clinical Review

    Directory of Open Access Journals (Sweden)

    Richard Baker

    2009-01-01

    Full Text Available Cutaneous scarring can cause patients symptoms ranging from the psychological to physical pain. Although the process of normal scarring is well described the ultimate cause of pathological scarring remains unknown. Similarly, exactly how early gestation fetuses can heal scarlessly remains unsolved. These questions are crucial in the search for a preventative or curative antiscarring agent. Such a discovery would be of enormous medical and commercial importance, not least because it may have application in other tissues. In the clinical context the assessment of scars is becoming more sophisticated and new physical, medical and surgical therapies are being introduced. This review aims to summarise some of the recent developments in scarring research for non-specialists and specialists alike.

  17. Occupationally Acquired American Cutaneous Leishmaniasis

    Directory of Open Access Journals (Sweden)

    Maria Edileuza Felinto de Brito

    2012-01-01

    Full Text Available We report two occupationally acquired cases of American cutaneous leishmaniasis (ACL: one accidental laboratory autoinoculation by contaminated needlestick while handling an ACL lesion sample, and one acquired during field studies on bird biology. Polymerase chain reaction (PCR assays of patient lesions were positive for Leishmania, subgenus Viannia. One isolate was obtained by culture (from patient 2 biopsy samples and characterized as Leishmania (Viannia naiffi through an indirect immunofluorescence assay (IFA with species-specific monoclonal antibodies (mAbs and by multilocus enzyme electrophoresis (MLEE. Patients were successfully treated with N-methyl-glucamine. These two cases highlight the potential risks of laboratory and field work and the need to comply with strict biosafety procedures in daily routines. The swab collection method, coupled with PCR detection, has greatly improved ACL laboratory diagnosis.

  18. [Cutaneous larva migrans in travelers].

    Science.gov (United States)

    Rubio, S; Ruiz, L; Gascón, J; Corachán, M

    1992-02-15

    Fifteen cases of cutaneous larva migrans (CLM) diagnosed in transcontinental travellers over a period of 4 years in the Department of Tropical Medicine in Hospital Clinic i Provincial of Barcelona were reviewed. The frequency of this disease as an imported pathology is on the increase and is related to the greater mobility of travellers today. Tourism is the main motive of the traveller and the geographic origin of the cases is cosmopolitan. The use of open footwear in 14 of the 15 patients is pointed out. The single lesion on the foot was the most frequent site. Thiabendazole was effective in 14 patients as was albendazole used in one patient. The secondary effects of thiabendazole, principally gastrointestinal disorders, headache, and dizziness are underlined.

  19. [Niacin deficiency and cutaneous immunity].

    Science.gov (United States)

    Ikenouchi-Sugita, Atsuko; Sugita, Kazunari

    2015-01-01

    Niacin, also known as vitamin B3, is required for the synthesis of coenzymes, nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). Niacin binds with G protein-coupled receptor (GPR) 109A on cutaneous Langerhans cells and causes vasodilation with flushing in head and neck area. Niacin deficiency due to excessive alcohol consumption, certain drugs or inadequate uptake in diet causes pellagra, a photosensitivity dermatitis. Recently several studies have revealed the mechanism of photosensitivity in niacin deficiency, which may pave a way for new therapeutic approaches. The expression level of prostaglandin E synthase (PTGES) is up-regulated in the skin of both pellagra patients and niacin deficient pellagra mouse models. In addition, pellagra is mediated through prostaglandin E₂-EP4 (PGE₂-EP4) signaling via reactive oxygen species (ROS) production in keratinocytes. In this article, we have reviewed the role of niacin in immunity and the mechanism of niacin deficiency-induced photosensitivity.

  20. Cutaneous tuberculosis, tuberculosis verrucosa cutis

    Directory of Open Access Journals (Sweden)

    Nilamani Mohanty

    2014-01-01

    Full Text Available Cutaneous tuberculosis because of its variability in presentation, wider differential diagnosis, and difficulty in obtaining microbiological confirmation continues to be the most challenging to diagnose for dermatologists in developing countries. Despite the evolution of sophisticated techniques such as polymerase chain reaction (PCR and enzyme-linked-immunosorbent serologic assay (ELISA, the sensitivity of new methods are not better than the isolation of Mycobacterium tuberculosum in culture. Even in the 21 st century, we rely on methods as old as the intradermal reaction purified protein derivative standard test and therapeutic trials, as diagnostic tools. We describe a case which has been diagnosed and treated as eczema by renowned physicians for 2 years. Incisional biopsy showed the presence of well-defined granulomas and ZN staining of the biopsy specimen showed the presence of acid fast bacilli; a trial of ATT (antitubercular therapy for 6 months lead to permanent cure of the lesion.

  1. Du gender mainstreaming au paritarisme : genèse d’un concept controversé

    OpenAIRE

    Sénac, Réjane

    2008-01-01

    La transposition nationale du gender mainstreaming est tout sauf évidente. Sa traduction française par ‘approche intégrée de l’égalité’ puis par ‘paritarisme’ en témoigne, car elle souligne la tendance à occulter, voire à nier, la spécificité de cette notion transnationale. L’analyse de sa genèse, au niveau international et européen, a pour but de souligner la spécificité de ce concept-méthode à la fois valeur et principe d’action. Les controverses autour de cette notion questionnent ainsi le...

  2. [Livedo-like cutaneous sarcoidosis].

    Science.gov (United States)

    Duboys, S; Cante, V; Monégier du Sorbier, C; Guillet, G

    2016-05-01

    The cutaneous signs of sarcoidosis are extremely polymorphous and may be classified under several different headings. Herein, we report the case of a 51-year-old female patient presenting bilateral livedo of the knees accompanied by systemic signs with polyarthralgia, impaired general state of health, weight loss, and a sensation of dyspnoea. Skin biopsy revealed giant-cell granuloma around the dermal vessels, with no caseous necrosis. Histopathological examination of the patient's blood vessels revealed no abnormalities. Laboratory tests showed high levels of angiotensin converting enzyme (1.5×ULN), bilateral mediastinal adenomegaly and incipient pulmonary fibrosis. Systemic sarcoidosis was diagnosed on the basis of the overall clinical and laboratory picture. The patient subsequently presented hepatic involvement and hypercalcaemia associated with the sarcoidosis; systemic corticosteroid therapy (prednisone) was initiated, with slow dose-reduction. The outcome was favourable with a return to normal laboratory values, regression of the adenomegaly and subsidence of the livedo. The literature contains reports of a number of cases of livedo heralding sarcoidosis. The majority of such cases involved young or middle-aged female patients of Asian origin presenting systemic sarcoidosis, with a high frequency of ocular and neural involvement. Livedo could be accounted for by the specific disposition of granulomas around the arterioles, resulting in disturbance of local blood flow, which was probably associated with the mechanical compression of vessels and with the micro-thrombi noted at histology. Livedo may be considered a clinical sign of cutaneous sarcoidosis. Laboratory tests to screen for sarcoidosis may be proposed in the exploration of atypical livedo. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  3. Chirurgie des pertes de subsistances cutanées dans l'ulcère de ...

    African Journals Online (AJOL)

    La présente étude, portant sur l'évolution post opératoire, après le traitement chirurgical des pertes de substances cutanées dans l'ulcère de Buruli au Bénin, vise essentiellement à déterminer les fréquences des techniques chirurgicales utilisées ainsi que les résultats de ces traitements dans deux centres spécialisées ...

  4. Une statuette en ivoire de 30 000 ans B.P. trouvée au Hohle Fels près de Schelklingen (Baden-Württemberg, Allemagne)

    OpenAIRE

    Conard, Nicholas J.; Floss, Harald

    2010-01-01

    En 1999, les fouilles menées par l’équipe de l’université de Tübingen au Hohle Fels près de Schelklingen ont permis de découvrir une statuette en ivoire de mammouth représentant une tête d’animal, vraisemblablement de cheval. L’objet provient du niveau géologique 3d dans une position intermédiaire entre des niveaux riches du Gravettien et de l’Aurignacien. Ce niveau est daté d’environ 30 000 B.P. Avec cette découverte, le Hohle Fels est, après le Vogelherd, le Hohlenstein-Stadel et le Geißenk...

  5. [Case report: disseminated cutaneous leishmaniasis (LCD)].

    Science.gov (United States)

    Mancheno-Valencia, Alexandra; Cabezas-Arteaga, Julia; Sacoto-Aizaga, Ketty; Arenas-Guzmáno, Roberto

    The World Health Organization (WHO) has classified leishmaniasis as an uncontrolled and emerging disease. In Ecuador, the only anecdotal cases of diffuse cutaneous leishmaniasis were recorded in 1994 and have not been formally published. This form can be differentiated from classical localized cutaneous leishmaniasis by the number of injuries, the clinical type of the main elementary lesions (papular and acneform), and a weak response to standard treatments. The case we report is a 34-year-old woman who presented with disseminated nodular lesions and ulcers of various sizes with erythematous edges and scars. We report the case and review diffuse cutaneous leishmaniasis and the differences that can be found with the other cutaneous variants. The diagnosis requires to be considered by primary care physicians in endemic areas and specialists, taking into account that this presentation can also occur in immunocompetent hosts.

  6. Cutaneous anthrax cases leading compartment syndrome

    Directory of Open Access Journals (Sweden)

    Emine Parlak

    2013-12-01

    Full Text Available Bacillus anthracis is the causative agent of anthrax. Anthrax is a zoonotic disease with three clinical forms. Clinical forms are skin, gastrointestinal and inhalational anthrax. Cutaneous anthrax is 95% of the cases. Cutaneous anthrax frequently defines itself. Clinical presentation of anthrax may be severe and complicated in some cases. There may seem complications like meningitis, septic shock and compartment syndrome. Compartment Syndrome is a rare complication of cutaneous anthrax and it is life threatening. Physicians working in the endemic area should be aware of this form. In this study, three cases were shown which developed compartment syndrome following cutaneous anthrax. J Microbiol Infect Dis 2013;3(4: 214-217

  7. Cutaneous cancers in Calabar, Southern Nigeria

    National Research Council Canada - National Science Library

    Asuquo, Maurice E; Ebughe, Godwin

    2009-01-01

    Globally, cutaneous cancers are among the most common form of cancer. Among Africans, there are significant differences in the types of skin cancer compared to those documented in patients from other countries...

  8. [Cutaneous leishmaniasis in a Syrian refugee].

    Science.gov (United States)

    de Wild, M; Wiersma, F H; Wolfs, T F W; van Hasselt, P M

    Cutaneous leishmaniasis is rare in the Netherlands, but it is endemic to Syria. The disease can manifest itself many years after initial exposure. Given the arrival of Syrian refugees in the Netherlands, awareness of this disease entity is warranted. A 5-year-old boy from Syria had investigations for hepatosplenomegaly. As an incidental finding a solitary, moderately demarcated, erythematous plaque was noted on his right cheek. It measured 4 × 2 cm and had a central haemorrhagic, exudative, honey-yellow slough. Due to the hepatosplenomegaly, as well as cutaneous leishmaniasis we also included its visceral form in the differential diagnosis. Additional investigations confirmed the diagnosis of cutaneous leishmaniasis. Given the rising incidence of leishmaniasis in Syria, the diagnosis of cutaneous leishmaniasis should be considered in a Syrian refugee who has an ulcerating nodule or plaque. A timely local treatment may improve long-term cosmetic outcome.

  9. Follicular infundibulum tumour presenting as cutaneous horn

    Directory of Open Access Journals (Sweden)

    Jayaraman M

    1996-01-01

    Full Text Available Tumour of follicular infundibulum is an organoid tumour with a plate like growth attached to the epidermis with connection from the follicular epithelium. We are reporting such a case unusually presenting as cutaneous horn.

  10. Auricular cutaneous leishmaniasis mimicking neoplastic disease.

    Science.gov (United States)

    Tarkan, Ö; Çetık, F; Uzun, S

    2012-08-01

    Leishmaniasis comprises a group of diseases transmitted by the bite of infected sand flies. There are three basic clinical forms of leishmaniasis: cutaneous, mucocutaneous and visceral. Leishmaniasis may mimic neoplastic lesions and other infectious diseases because of similar disease localisation, physical characteristics and histopathological findings. A 35-year-old man was referred to our clinic with a presumed diagnosis of angiolymphoid hyperplasia of the auricle; however, this lesion proved to be cutaneous leishmaniasis. The definitive diagnosis was reached by identifying the parasites on smears obtained from the lesion. It should be borne in mind that cutaneous leishmaniasis presenting as isolated auricular lesions may mimic neoplasia. In the present case report, we discuss auricular cutaneous leishmaniasis and we review the relevant literature.

  11. Systemic amyloidosis with an exceptional cutaneous presentation.

    Science.gov (United States)

    Barja, Juan; Piñeyro, Francisca; Almagro, Manuel; Sacristán, Felipe; Rodríguez-Lojo, Romina; Fernández-Jorge, Beatriz; Ruanova, Sonia; García-Silva, Jesus

    2013-01-15

    Alopecia and nail distrophy are rare signs of systemic amyloidosis. We present a case with both manifestations and give a brief review of the cutaneous signs of this disease. A biopsy of affected or unaffected skin may provide the diagnosis.

  12. Mise au point

    African Journals Online (AJOL)

    31 mai 2013 ... laryngocèle interne. Une surinfection a été notée chez trois patients réalisant ainsi le tableau de pyolaryngocèle. Tous les patients ont eu un examen clinique complet comportant un examen OrL et cervico-facial ainsi qu'un examen laryngé au ... pas en communication avec la lumière laryngée. La taille.

  13. Le CRDI au Mali

    International Development Research Centre (IDRC) Digital Library (Canada)

    sur la sécurité alimentaire internationale. Le CRDI continue de soutenir des travaux de recherche au Mali, quoique dans une moindre mesure en raison de la .... souvent tenues à l'écart du processus décisionnel. Les chercheurs tentent de déterminer de quelles manières les jeunes femmes du Mali et des pays avoisinants ...

  14. Le CRDI au Maroc

    International Development Research Centre (IDRC) Digital Library (Canada)

    visant à aider les secteurs de l'agriculture et du tourisme à s'adapter aux changements climatiques. Dans le cadre de recherches antérieures sur la mise au point .... France. Les manifestations et protestations survenues après 2010 et auxquelles on a donné le nom de Printemps arabe ont été annonciatrices de profondes ...

  15. Le CRDI au Kenya

    International Development Research Centre (IDRC) Digital Library (Canada)

    et de l'agriculture. En produisant des connaissances dans ces secteurs essentiels, le programme contribuera à la sécurité alimentaire et améliorera la santé au Kenya. Les noms et les frontières indiqués sur la carte n'impliquent ni reconnaissance ni acceptation officielle de la part du CRDI. C. U. R. T. C. A. R. N. EM. A. R. K.

  16. Angiogenesis in cutaneous disease: Part II

    OpenAIRE

    Laquer, V; Hoang, V.; Nguyen, A; Kelly, KM

    2009-01-01

    This review will discuss the role of angiogenesis in specific cutaneous diseases. Scientific evidence now points to the role of angiogenesis in tumor development and many other cutaneous disorders. Angiogenesis is a complex process that involves angiogenic growth factors and inhibitors, many of which could be a potential target for pharmacologic intervention. Antiangiogenic agents have recently been applied to dermatologic diseases with promising efficacy. Learning objectives: After completin...

  17. Cutaneous mosaicisms: concepts, patterns and classifications

    OpenAIRE

    Kouzak, Samara Silva; Mendes, Marcela Sena Teixeira; Costa, Izelda Maria Carvalho

    2013-01-01

    A mosaic is an organism composed of two or more genetically distinct cell populations derived from a genetically homogeneous zygote. Cutaneous mosaicisms are the clinical expressions of these disorders. The main event which allows the existence of mosaicism is a genetic mutation, either structural or functional. Cutaneous mosaicisms usually manifest by specific patterns on the skin and the archetypic pattern is the system of Blaschko lines, but others include checkerboard, phylloid, large pat...

  18. Cutaneous leukocytoclastic vasculitis associated with levofloxacin therapy

    Directory of Open Access Journals (Sweden)

    Dana Blyth

    2012-01-01

    Full Text Available Many cases of cutaneous vasculitis are druginduced with histology revealing leukocytoclastic vasculitis (LCV. We present a case of levofloxacin- associated LCV successfully treated with prednisone and cessation of the offending drug. Although case reports describe a link between LCV and older fluoroquinolones, such as ciprofloxacin and ofloxacin, recent reports have implicated the newer fluoroquinolone levofloxacin. Recognition of fluoroquinoloneinduced cutaneous vasculitis is important as continuation or re-exposure of the offending agent may have life-threatening consequences.

  19. Dimensionnement des ouvrages génie civil au calcul sismique

    CERN Document Server

    Poehler, M

    2001-01-01

    L'énergie la plus importante libérée au niveau de la cro te terrestre par un séisme est sous forme d'ondes superficielles, appelées ondes de Rayleigh. Sous l'effet de ces ondes à déplacements verticaux de forme elliptique, le sol et les bâtiments qu'il soutient vibrent dans une gamme de fréquences de 0,1 à 30 hertz. Cette gamme de valeurs est spécialement nocive pour les bâtiments élancés. Les calculs de dimensionnement des ouvrages de génie civil prennent en compte ce type de sollicitation, via des forces horizontales de remplacement. Les différentes normes nationales définissent une accélération nominale due au séisme, au moyen d'une combinaison de classes d'ouvrages et de zones sismiques. De plus, des mesures spéciales de dispositions constructives et de conception architecturale sont prescrites. Les statistiques montrent que 90% des ouvrages ont été construits avant l'introduction, fin des années 80, des normes de construction parasismiques modernes.

  20. Laser therapy for cutaneous sarcoidosis: A review

    Directory of Open Access Journals (Sweden)

    Teo Soleymani

    2016-03-01

    Full Text Available Sarcoidosis is a systemic, multi-organ disease of unknown etiology characteristically defined by the development of non-caseating granulomas. The development of sarcoidosis has been associated with a number of environmental and microbacterial factors coupled with genetic susceptibility. Depending on the type, location and distribution of disease, sarcoidosis can cause functional impairment, symptomatic distress, scarring and disfigurement. The advent of lasers as precise, minimally destructive surgical tools has allowed for their development as promising alternatives that minimize the morbidity associated with current therapies.In this paper, we reviewed the role of laser therapy in the treatment of cutaneous sarcoidosis. A comprehensive search of the Cochrane Library, MEDLINE and PUBMED databases was performed to identify relevant literatures investigating the role of laser therapy in the treatment of cutaneous sarcoidosis. In our opinion, laser therapy, particularly PDL, appears to be an effective, safe and generally well-tolerated modality for the treatment of cutaneous sarcoidosis and should be considered in patients with localized cutaneous disease that is refractory to conventional treatments. Less is known about the efficacy and tolerability of ablative laser therapy for the treatment of cutaneous sarcoidosis, though the limited data appears promising as well. With that said, however, the data is limited and warrants a need for additional larger, randomized controlled studies to further investigate the utility and efficacy of laser therapy in the treatment of cutaneous sarcoidosis.

  1. Cutaneous Manifestations of Human and Murine Leishmaniasis

    Science.gov (United States)

    Scorza, Breanna M.; Carvalho, Edgar M.; Wilson, Mary E.

    2017-01-01

    The leishmaniases are diseases caused by pathogenic protozoan parasites of the genus Leishmania. Infections are initiated when a sand fly vector inoculates Leishmania parasites into the skin of a mammalian host. Leishmania causes a spectrum of inflammatory cutaneous disease manifestations. The type of cutaneous pathology is determined in part by the infecting Leishmania species, but also by a combination of inflammatory and anti-inflammatory host immune response factors resulting in different clinical outcomes. This review discusses the distinct cutaneous syndromes described in humans, and current knowledge of the inflammatory responses associated with divergent cutaneous pathologic responses to different Leishmania species. The contribution of key hematopoietic cells in experimental cutaneous leishmaniasis in mouse models are also reviewed and compared with those observed during human infection. We hypothesize that local skin events influence the ensuing adaptive immune response to Leishmania spp. infections, and that the balance between inflammatory and regulatory factors induced by infection are critical for determining cutaneous pathology and outcome of infection. PMID:28629171

  2. Cutaneous Manifestations of Human and Murine Leishmaniasis

    Directory of Open Access Journals (Sweden)

    Breanna M. Scorza

    2017-06-01

    Full Text Available The leishmaniases are diseases caused by pathogenic protozoan parasites of the genus Leishmania. Infections are initiated when a sand fly vector inoculates Leishmania parasites into the skin of a mammalian host. Leishmania causes a spectrum of inflammatory cutaneous disease manifestations. The type of cutaneous pathology is determined in part by the infecting Leishmania species, but also by a combination of inflammatory and anti-inflammatory host immune response factors resulting in different clinical outcomes. This review discusses the distinct cutaneous syndromes described in humans, and current knowledge of the inflammatory responses associated with divergent cutaneous pathologic responses to different Leishmania species. The contribution of key hematopoietic cells in experimental cutaneous leishmaniasis in mouse models are also reviewed and compared with those observed during human infection. We hypothesize that local skin events influence the ensuing adaptive immune response to Leishmania spp. infections, and that the balance between inflammatory and regulatory factors induced by infection are critical for determining cutaneous pathology and outcome of infection.

  3. Thyroïdectomies pratiquées sous anesthésie locale au Centre Hospitalier Universitaire d'Antananarivo

    Science.gov (United States)

    Razafindrakoto, Rex Mario; Razafindranaivo, Mananjara Nandrianina; Valisoa, Herimalalaniaina Angelo; Schammirah, Mahamad Rojovolaarivony; Randriamboavonjy, Rado

    2015-01-01

    Menée le plus souvent sous anesthésie générale, la chirurgie thyroïdienne peut aussi être pratiquée sous anesthésie régionale ou sous anesthésie locale. Notre objectif a été de rapporter l'expérience du Centre Hospitalier Universitaire d'Antananarivo sur l'anesthésie locale dans les thyroïdectomies. La drogue employée dans notre protocole anesthésique a été le fentanyl, administré en intraveineuse directe, associé à une infiltration sous-cutanée de lidocaïne suivant la ligne d'incision. Le/la patient(e) n'a pas été intubé(e), l'oxygène étant délivré au niveau des cavités nasales. Ont été étudiés le type de chirurgie thyroïdienne, la durée de l'intervention, la satisfaction des patient(e)s vis-à-vis de la qualité de l'anesthésie, et le coût de l'intervention. Sur 567 thyroïdectomies effectuées, 51,68% (n= 293) ont été des lobo-isthmectomies gauches, 44,44% (n= 252) des lobo-isthmectomies droites, 2,82% (n= 16) des thyroïdectomies subtotales ou totales, 1,06% (n= six) des totalisations pour carcinomes thyroïdiens. La durée des interventions a varié de 30 à 90 minutes. Un total de 83,95% (n= 476) des patient(e)s a été très satisfait de la qualité de l'anesthésie et 15,87% autres (n= 90) satisfait. Les suites opératoires ont été bonnes dans la majorité des cas. Le coût d'une thyroïdectomie a été évalué à 100- 150 dollars américains. L'anesthésie locale utilisée dans les thyroïdectomies effectuées au Centre Hospitalier Universitaire d'Antananarivo est simple, rapide, d'un coût moyen, et permet d'alarmer précocement le chirurgien en cas de lésion d'un nerf laryngé inférieur. PMID:26587128

  4. Cutaneous lupus erythematosus: An update

    Science.gov (United States)

    Grönhagen, Carina M; Nyberg, Filippa

    2014-01-01

    Lupus erythematosus (LE) is a chronic, autoimmune, multisystem disease that displays many diverse symptoms in which localized cutaneous LE (CLE) is on one end of the spectrum and severe systemic LE (SLE) on the other end. The underlying cause of LE is unknown but the etiology is thought to be multifactorial and polygenic. CLE is a disfiguring, chronic skin disease, with a significant impact on the patients’ everyday life. CLE are further divided into three main subsets: Acute CLE (ACLE), subacute CLE (SCLE) and chronic CLE (CCLE), where classic discoid LE (DLE) is the most common form. These subsets are defined by clinical symptoms, average duration of symptoms and histological and serological findings, although, the three subtypes can have overlapping clinical features. CLE patients display well-defined skin lesions, often in sun-exposed areas. The disease often has a chronic and relapsing course that can be induced or aggravated by UV light. It is important to confirm a CLE diagnosis histopathologically by a biopsy and in that there are several differential diagnoses and because CLE is a chronic disease in which regular follow-up is important and systemic treatment is sometimes indicated. PMID:24616847

  5. Mise au point

    African Journals Online (AJOL)

    31 mai 2013 ... L'attitude théra- peutique dépend du type de la laryngocèle. en effet, le traitement endoscopique au laser CO2 a gagné beaucoup d'intérêt ces dernières années. MATÉRIEL ET MÉTHOdES. Il s'agit d'une étude rétrospective portant sur 9 patients porteurs d'une laryngocèle colligés sur une période de 14.

  6. Le CRDI au Ghana

    International Development Research Centre (IDRC) Digital Library (Canada)

    poussée en mathématiques aux spécialistes de demain afin qu'ils puissent relever les défis pressants qui se posent en matière d'environnement, de santé et d'économie. La bourse de chercheur invité que le CRDI a octroyée en 2001 au regretté. John Atta-Mills, qui a par la suite été prési- dent du Ghana de 2009 à 2012, ...

  7. Au pairs on Facebook

    DEFF Research Database (Denmark)

    Dalgas, Karina Märcher

    2016-01-01

    Ethnographers are increasingly making use of Facebook to acquire access and general acquaintance with their field of study. However, little has been written on how Facebook is used methodologically in research that does not have social media sites as the main focus of interest. This article argues...... that engagement with Facebook as a methodological tool can be useful in research among migrants in highly politicised fields. Pointing to a discursive construction of Filipina au pairs as victims of labour exploitation, the article shows how fieldwork on Facebook enables the exploration of the ways in which...... and on Facebook....

  8. Epigenetic alterations in metastatic cutaneous carcinoma.

    Science.gov (United States)

    Darr, Owen A; Colacino, Justin A; Tang, Alice L; McHugh, Jonathan B; Bellile, Emily L; Bradford, Carol R; Prince, Mark P; Chepeha, Douglas B; Rozek, Laura S; Moyer, Jeffrey S

    2015-07-01

    Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are the 2 most common cutaneous carcinomas. Molecular profiles predicting metastasis of these cancers have not been identified. Epigenetic profiles of 37 primary cases of cutaneous SCC and BCC were quantified via the Illumina Goldengate Cancer Panel. Differential protein expression by metastatic potential was analyzed in 110 total cases by immunohistochemical (IHC) staining. Unsupervised hierarchical clustering analysis revealed that metastatic BCCs had a methylation profile resembling cutaneous SCCs. Metastatic cutaneous SCCs were found to be hypermethylated at FRZB (median methylation: 46.7% vs 4.7%; p = 4 × 10(-5) ). Metastatic BCCs were found to be hypomethylated at MYCL2 (median methylation: 3.8% vs 83.4%; p = 1.9 × 10(-6) ). Immunohistochemical staining revealed few differences between metastatic and nonmetastatic cancers. Metastatic primary BCCs and cutaneous SCCs had distinct epigenetic profiles when compared to their nonmetastatic counterparts. Epigenetic profiling may prove useful in future diagnosis and prevention of advanced nonmelanoma skin cancers. © 2014 Wiley Periodicals, Inc.

  9. Charged particle density distributions in Au+ Au collisions at ...

    Indian Academy of Sciences (India)

    ... measured in Au + Au collisions using the BRAHMS detector at RHIC. The results are presented as a function of the collision centrality and the center of mass energy. They are compared to the predictions of different parton scattering models and the important role of hard scattering processes at RHIC energies is discussed ...

  10. Proton pump inhibitor-induced subacute cutaneous lupus erythematosus

    DEFF Research Database (Denmark)

    Sandholdt, L H; Laurinaviciene, R; Bygum, Anette

    2014-01-01

    Drug-induced subacute cutaneous lupus erythematosus (SCLE) has been known in the literature since 1985 and is increasingly recognized.......Drug-induced subacute cutaneous lupus erythematosus (SCLE) has been known in the literature since 1985 and is increasingly recognized....

  11. Cutaneous mucormycosis in advanced HIV disease

    Directory of Open Access Journals (Sweden)

    José Moreira

    2016-11-01

    Full Text Available Angionvasive mucormycosis is an emerging fungal disease known to affect mainly diabetics or subjects with profound neutropenia. Infection usually occurs through the inhalation route, but cutaneous inoculation may occur after trauma or burns. However, mucormycosis remains unusual in HIV infection. We report a fatal case of cutaneous mucormycosis due to Rhizopus arrhizus involving the scalp following herpes zoster infection. The patient was a 42-year-old man with advanced AIDS failing on salvage antiretroviral therapy. The fungus was diagnosed on the basis of histopathology and culture. Our case emphasizes the need to consider mucormycosis in the differential diagnosis of necrotic cutaneous lesions in patients with late-stage HIV disease.

  12. Cutaneous mechanisms of isometric ankle force control

    DEFF Research Database (Denmark)

    Choi, Julia T; Jensen, Jesper Lundbye; Leukel, Christian

    2013-01-01

    The sense of force is critical in the control of movement and posture. Multiple factors influence our perception of exerted force, including inputs from cutaneous afferents, muscle afferents and central commands. Here, we studied the influence of cutaneous feedback on the control of ankle force...... output. We used repetitive electrical stimulation of the superficial peroneal (foot dorsum) and medial plantar nerves (foot sole) to disrupt cutaneous afferent input in 8 healthy subjects. We measured the effects of repetitive nerve stimulation on (1) tactile thresholds, (2) performance in an ankle force......-matching and (3) an ankle position-matching task. Additional force-matching experiments were done to compare the effects of transient versus continuous stimulation in 6 subjects and to determine the effects of foot anesthesia using lidocaine in another 6 subjects. The results showed that stimulation decreased...

  13. Modern radiation therapy for primary cutaneous lymphomas

    DEFF Research Database (Denmark)

    Specht, Lena; Dabaja, Bouthaina; Illidge, Tim

    2015-01-01

    Primary cutaneous lymphomas are a heterogeneous group of diseases. They often remain localized, and they generally have a more indolent course and a better prognosis than lymphomas in other locations. They are highly radiosensitive, and radiation therapy is an important part of the treatment......, either as the sole treatment or as part of a multimodality approach. Radiation therapy of primary cutaneous lymphomas requires the use of special techniques that form the focus of these guidelines. The International Lymphoma Radiation Oncology Group has developed these guidelines after multinational...... meetings and analysis of available evidence. The guidelines represent an agreed consensus view of the International Lymphoma Radiation Oncology Group steering committee on the use of radiation therapy in primary cutaneous lymphomas in the modern era....

  14. Angiogenesis in cutaneous disease: part II.

    Science.gov (United States)

    Laquer, Vivian; Hoang, Van; Nguyen, Amy; Kelly, Kristen M

    2009-12-01

    This review will discuss the role of angiogenesis in specific cutaneous diseases. Scientific evidence now points to the role of angiogenesis in tumor development and many other cutaneous disorders. Angiogenesis is a complex process that involves angiogenic growth factors and inhibitors, many of which could be a potential target for pharmacologic intervention. Antiangiogenic agents have recently been applied to dermatologic diseases with promising efficacy. After completing this learning activity, participants should be able to recognize cutaneous diseases where angiogenesis is likely to be an important factor, recognize scenarios where angiogenic therapy may be useful in conjunction with traditional therapies, and be able to use angiogenic-mediating agents in the treatment of dermatologic disease.

  15. Cutaneous sarcoidosis: A rare case report

    Directory of Open Access Journals (Sweden)

    Bindu Suparna M, Joshi Shivani

    2014-07-01

    Full Text Available Sarcoidosis is a Greek word (Sarco means flesh and Eido means type or like. Cutaneous sarcoidosis occurs in up to one third of patients with systemic sarcoidosis. This disease is characterised by the presence of non – caseating epitheloid cell granulomas in the skin. Cutaneous sarcoidosis presents as a diagnostic challenge to the dermatopathologists due to its varied presentations and almost identical histologic pictures. Hence, exclusion of infectious causes and compatibility with clinical and radiologic picture serve as significant criteria to come up to a diagnosis. Sometimes; skin lesions are the first manifestation of systemic sarcoidosis. This is not a contagious or allergic disease. There is a risk of development of systemic manifestations at a later date; for which a close follow up is a must. We are presenting a case of cutaneous sarcoidosis, which later on progress to sarcoidosis with systemic manifestations.

  16. Subacute cutaneous lupus erythematosus presenting as poikiloderma.

    LENUS (Irish Health Repository)

    Hughes, R

    2012-02-01

    Subacute cutaneous lupus erythematosus (SCLE) is a recognised variant of lupus erythematosus (LE), which accounts for 10-15% of all cases of cutaneous LE, occurring most commonly in young to middle-aged white women. Diagnosis is based on the detection of anti-Ro\\/SS-A antibodies in the skin and serum, characteristic clinical and histological cutaneous involvement, and relatively mild systemic involvement. Several unusual variants of SCLE have been reported including erythrodermic SCLE, SCLE with vitiligo-like lesions, acral SCLE and bullous SCLE. Poikoilodermatous SCLE is a recognised but rare variant of SCLE. There are currently only two case reports, comprising five individual cases, in the literature. We present a case of SCLE in which the main clinical findings were an extensive photodistributed poikilodermatous rash and alopecia.

  17. Cutaneous Manifestations of Systemic Lupus Erythematosus

    Science.gov (United States)

    Uva, Luís; Miguel, Diana; Pinheiro, Catarina; Freitas, João Pedro; Marques Gomes, Manuel; Filipe, Paulo

    2012-01-01

    Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease of unknown etiology with many clinical manifestations. The skin is one of the target organs most variably affected by the disease. The American College of Rheumatology (ACR) established 11 criteria as a classificatory instrument to operationalise the definition of SLE in clinical trials. They were not intended to be used to diagnose individuals and do not do well in that capacity. Cutaneous lesions account for four of these 11 revised criteria of SLE. Skin lesions in patients with lupus may be specific or nonspecific. This paper covers the SLE-specific cutaneous changes: malar rash, discoid rash, photosensitivity, and oral mucosal lesions as well as SLE nonspecific skin manifestations, their pathophysiology, and management. A deeper thorough understanding of the cutaneous manifestations of SLE is essential for diagnosis, prognosis, and efficient management. Thus, dermatologists should cooperate with other specialties to provide optimal care of SLE patient. PMID:22888407

  18. Cutaneous Manifestations of Systemic Lupus Erythematosus

    Directory of Open Access Journals (Sweden)

    Luís Uva

    2012-01-01

    Full Text Available Systemic lupus erythematosus (SLE is a multiorgan autoimmune disease of unknown etiology with many clinical manifestations. The skin is one of the target organs most variably affected by the disease. The American College of Rheumatology (ACR established 11 criteria as a classificatory instrument to operationalise the definition of SLE in clinical trials. They were not intended to be used to diagnose individuals and do not do well in that capacity. Cutaneous lesions account for four of these 11 revised criteria of SLE. Skin lesions in patients with lupus may be specific or nonspecific. This paper covers the SLE-specific cutaneous changes: malar rash, discoid rash, photosensitivity, and oral mucosal lesions as well as SLE nonspecific skin manifestations, their pathophysiology, and management. A deeper thorough understanding of the cutaneous manifestations of SLE is essential for diagnosis, prognosis, and efficient management. Thus, dermatologists should cooperate with other specialties to provide optimal care of SLE patient.

  19. Cutaneous manifestations of systemic lupus erythematosus.

    Science.gov (United States)

    Uva, Luís; Miguel, Diana; Pinheiro, Catarina; Freitas, João Pedro; Marques Gomes, Manuel; Filipe, Paulo

    2012-01-01

    Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease of unknown etiology with many clinical manifestations. The skin is one of the target organs most variably affected by the disease. The American College of Rheumatology (ACR) established 11 criteria as a classificatory instrument to operationalise the definition of SLE in clinical trials. They were not intended to be used to diagnose individuals and do not do well in that capacity. Cutaneous lesions account for four of these 11 revised criteria of SLE. Skin lesions in patients with lupus may be specific or nonspecific. This paper covers the SLE-specific cutaneous changes: malar rash, discoid rash, photosensitivity, and oral mucosal lesions as well as SLE nonspecific skin manifestations, their pathophysiology, and management. A deeper thorough understanding of the cutaneous manifestations of SLE is essential for diagnosis, prognosis, and efficient management. Thus, dermatologists should cooperate with other specialties to provide optimal care of SLE patient.

  20. Diagnosis of Cutaneous Leishmaniasis by Multiplex PCR

    Directory of Open Access Journals (Sweden)

    M Heiat

    2010-07-01

    Full Text Available Introduction: Annually, more than 14 million people are reported to be infected with Leishmaniasis all over the world. In Iran, this disease is seen in the form of cutaneous and visceral leishmaniasis, of which the cutaneous form is more wide spread. In recent years, cutaneous leishmaniaisis is diagnosed by PCR utilizing specific primers in order to amplify different parasite genes including ribosomal RNA genes, kinetoplast DNA or tandem repeating sequences. The aim of this research was to detect early stage cutaneous leishmaniasis using Multiplex-PCR technique. Methods: In this study, 67 samples were prepared from patients with cutaneous leishmaniasis. DNA was extracted with phenolchloroform. Each specimen was analyzed using two different pairs of PCR primers. The sensitivity of each PCR was optimized on pure Leishmania DNA prior to use for diagnosis. Two standard parasites L. major and L. tropica were used as positive control. Results: DNA amplification fragments were two 115 bp and 683 bp for AB and UL primers, respectively. The sensitivity of two primers was not equal for detection of L. major and L. tropica. The sensivity of PCR with AB primer was 35 cells, while that for UL primer was 40 cells. Conclusion: The results of this study indicate that PCR is a sensitive diagnostic assay for cutaneous leishmaniasis and could be employed as the new standard for routine diagnosis when species identification is not required. However, the ability to identify species is especially important in prognosis of the disease and in deciding appropriate therapy, especially in regions where more than one type of species and disease are seen by clinicians.

  1. Cutaneous vasculitides: Clinico-pathological correlation

    Directory of Open Access Journals (Sweden)

    Gupta Suruchi

    2009-01-01

    Full Text Available Background: Cutaneous vasculitis presents as a mosaic of clinical and histological findings. Its pathogenic mechanisms and clinical manifestations are varied. Aims: To study the epidemiological spectrum of cutaneous vasculitides as seen in a dermatologic clinic and to determine the clinico-pathological correlation. Methods: A cohort study was conducted on 50 consecutive patients clinically diagnosed as cutaneous vasculitis in the dermatology outdoor; irrespective of age, sex and duration of the disease. Based on the clinical presentation, vasculitis was classified according to modified Gilliam′s classification. All patients were subjected to a baseline workup consisting of complete hemogram, serum-creatinine levels, serum-urea, liver function tests, chest X-ray, urine (routine and microscopic examination besides antistreptolysin O titer, Mantoux test, cryoglobulin levels, antineutrophilic cytoplasmic antibodies and hepatitis B and C. Histopathological examination was done in all patients while immunofluorescence was done in 23 patients. Results: Out of a total of 50 patients diagnosed clinically as cutaneous vasculitis, 41 were classified as leukocytoclastic vasculitis, 2 as Heinoch−Schonlein purpura, 2 as urticarial vasculitis and one each as nodular vasculitis, polyarteritis nodosa and pityriasis lichenoid et varioliforme acuta. Approximately 50% of the patients had a significant drug history, 10% were attributed to infection and 10% had positive collagen workup without any overt manifestations, while 2% each had Wegener granulomatosis and cryoglobulinemia. No cause was found in 26% cases. Histopathology showed features of vasculitis in 42 patients. Only 23 patients could undergo direct immunofluorescence (DIF, out of which 17 (73.9% were positive for vasculitis. Conclusions: Leukocytoclastic vasculitis was the commonest type of vaculitis presenting to the dermatology outpatient department. The workup of patients with cutaneous vasculitis

  2. Cutaneous hyperpigmentation induced by doxycycline: a case series

    NARCIS (Netherlands)

    Keijmel, S.P.; Kasteren, M.E.E. van; Blokx, W.A.M.; Meer, J.W.M. van der; Rossum, M.M. van; Bleeker-Rovers, C.P.

    2015-01-01

    Cutaneous hyperpigmentation is a well-known side effect of tetracyclines, but doxycycline-induced cutaneous hyperpigmentation has only been described in one patient with a therapeutic dosage of doxycycline, and in one patient using suprapharmacological doses. We describe four patients with cutaneous

  3. Problems in Cutaneous Communication from Psychophysics to Information Processing.

    Science.gov (United States)

    Gilmer, B. VonHaller; Clark, Leslie L., Ed.

    After reviewing the history of communication through the skin, this paper considers recent research into the problem of cutaneous stimulation induced both mechanically and electrically. The general demands of a cutaneous communication system are discussed, and four primary dimensions of cutaneous stimulation are summarized (locus, intensity,…

  4. Cutaneous Silicone Granuloma Mimicking Breast Cancer after Ruptured Breast Implant

    Directory of Open Access Journals (Sweden)

    Waseem Asim Ghulam El-Charnoubi

    2011-01-01

    Full Text Available Cutaneous manifestations due to migration of silicone from ruptured implants are rare. Migrated silicone with cutaneous involvement has been found in the chest wall, abdominal wall, and lower extremities. We describe a case of cutaneous silicone granuloma in the breast exhibiting unusual growth mimicking breast cancer after a ruptured implant.

  5. Cutaneous metastasis from gastrointestinal adenocarcinoma of unknown primary origin*

    Science.gov (United States)

    Junqueira, Ana Lucia Ariano; Corbett, Ana Maria França; de Oliveira Filho, Jayme; Nasser, Kassila da Rosa; Haddad, Natalie Nejem; Tebet, Ana Carolina Franco

    2015-01-01

    Cutaneous metastasis is a rare manifestation of visceral malignancies that indicates primarily advanced disease. Due to its low incidence and similarity to other cutaneous lesions, it is not uncommon to have a delayed diagnosis and a shortened prognosis. We describe the case of a patient who presented with a cutaneous nodule in the sternal region as a first sign of malignancy. PMID:26375228

  6. Cutaneous metastasis from gastrointestinal adenocarcinoma of unknown primary origin.

    Science.gov (United States)

    Junqueira, Ana Lucia Ariano; Corbett, Ana Maria França; Oliveira Filho, Jayme de; Nasser, Kassila da Rosa; Haddad, Natalie Nejem; Tebet, Ana Carolina Franco

    2015-01-01

    Cutaneous metastasis is a rare manifestation of visceral malignancies that indicates primarily advanced disease. Due to its low incidence and similarity to other cutaneous lesions, it is not uncommon to have a delayed diagnosis and a shortened prognosis. We describe the case of a patient who presented with a cutaneous nodule in the sternal region as a first sign of malignancy.

  7. Cutaneous manifestations of HIV/AIDS: Part I | Dlova | Southern ...

    African Journals Online (AJOL)

    Human immunodeficiency virus (HIV) infection can lead to a variety of clinical cutaneous manifestations. These cutaneous disorders occur universally during the course of HIV infection. Cutaneous manifestations of HIV are very diverse. The course and clinical presentation of HIV in individuals who have access to highly ...

  8. Cutaneous Manifestation of Drug Allergy and Hypersensitivity.

    Science.gov (United States)

    Zalewska-Janowska, Anna; Spiewak, Radoslaw; Kowalski, Marek L

    2017-02-01

    Drug hypersensitivity reactions may manifest with either organ-specific or systemic symptoms, but cutaneous eruptions are the most common manifestations. Different medications may cause identical skin symptoms, whereas hypersensitivity to a single drug may manifest with various patterns of symptoms depending on the pathomechanism of hypersensitivity. Drug reactions should be also taken into account in the differential diagnosis of numerous skin rashes. Analysis of morphology of drug-induced lesions, about potential immunologic or nonimmunological mechanisms, is important for the final diagnosis. Thus, here the authors present a morphologic approach to the diagnosis of cutaneous drug-induced eruptions. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. Dermatoscopy in diagnosing maculopapular cutaneous mastocytosis

    Directory of Open Access Journals (Sweden)

    Popadić Mirjana

    2016-01-01

    Full Text Available The diagnosis of cutaneous mastocytosis is based on the clinical finding of the pigmented macules or papules, positive Darier's sign and a dermal infiltrate composed of mast cells that can be better visualized by the use of special stains (Giemsa or Toluidine blue. Clinical, dermatoscopic and histopathological presentations of new appearing pigmented lesions in a female patient were presented. Dermatoscopic findings of pigment network-like structure combined with parallel pigmented lines and central reddish background in a adult patient with new appearing pigmented lesions should led us to searching for cutaneous mastocytosis.

  10. Paraneoplastic cutaneous manifestations: concepts and updates*

    Science.gov (United States)

    da Silva, Josenilson Antônio; Mesquita, Kleyton de Carvalho; Igreja, Ana Carolina de Souza Machado; Lucas, Isabella Cristina Rodrigues Naves; Freitas, Aline Ferreira; de Oliveira, Sandra Maximiano; Costa, Izelda Maria Carvalho; Campbell, Iphis Tenfuss

    2013-01-01

    The skin often signals systemic changes. Some neoplastic diseases that affect internal organs may trigger several cutaneous manifestations. Although these dermatoses are relatively unusual, the recognition of some typical paraneoplastic dermatoses may lead to the early diagnosis of a neoplasm and determine a better prognosis. In this review article, we discuss the paraneoplastic cutaneous manifestations strongly associated with neoplasms, which include acanthosis nigricans maligna, tripe palms, erythema gyratum repens, Bazex syndrome, acquired hypertrichosis lanuginosa, necrolytic migratory erythema, Leser-Trélat sign and paraneoplastic pemphigus. We also review the clinical manifestations of each condition and include updated knowledge on disease pathogenesis. PMID:23538999

  11. Cutaneous osteosarcoma arising from a burn scar

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Min A.; Yi, Jaehyuck [Kyungpook National University, Department of Radiology, College of Medicine, Daegu (Korea, Republic of); Kyungpook National University Hospital, Department of Radiology, Daegu (Korea, Republic of); Chae, Jong Min [Kyungpook National University, Department of Pathology, College of Medicine, Daegu (Korea, Republic of)

    2017-04-15

    Tumors that develop in old burn scars are usually squamous cell carcinomas. Sarcomas have also been reported, albeit rarely. To our knowledge, there has been only one case report of an extraskeletal osteosarcoma arising in a prior burn scar reported in the English-language literature, mainly discussing the clinicopathological features. Herein, we present a case of cutaneous osteosarcoma visualized as a mineralized soft-tissue mass arising from the scar associated with a previous skin burn over the back. This seems to be the first report describing the imaging features of a cutaneous osteosarcoma from an old burn scar. (orig.)

  12. Cutaneous toxoplasmosis in an immunosuppressed dog

    Directory of Open Access Journals (Sweden)

    T.S. Oliveira

    2014-06-01

    Full Text Available A seven-year-old female spayed Schnauzer was presented with cutaneous ulcerated nodular lesions shortly after the beginning of an immunosuppressive treatment for immune-mediated hemolytic disease. Cytology was performed and a great number of neutrophils and banana-shaped organisms were observed. Biopsy showed a neutrophilic and histiocytic dermatitis and panniculitis with myriads of intralesional bradyzoites cysts and tachyzoites. PCR analysis was positive for Toxoplasma gondii and negative for Neospora caninum. Immunohistochemistry confirmed intralesional T. gondii antigens. This study reports a rare case of cutaneous toxoplasmosis in an immunosuppressed dog.

  13. Lichenoid type cutaneous hyperpigmentation induced by nebivolol.

    Science.gov (United States)

    Aslan, Abdullah Nabi; Güney, Murat Can; Akçay, Murat; Keleş, Telat; Bozkurt, Engin

    2017-04-01

    Cutaneous hyperpigmentation is a common and well-defined side effect of many drugs, such as non-steroidal anti-inflammatory drugs, beta-blockers, and tetracyclines, but to the best of our knowledge there is no case of skin discoloration related to nebivolol in the literature. Presently described is lichenoid type cutaneous hyperpigmentation in a 46-year-old female patient. Hyperpigmentation emerged 3 months after initiating use of nebivolol and resolved after cessation of drug use. It was concluded that effect emerged as result of therapeutic doses of nebivolol.

  14. Magnetoresistance of Au films

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, D. L., E-mail: zhangdl@iphy.ac.cn; Song, X. H.; Zhang, X. [Institute of Physics, Chinese Academy of Sciences, Beijing 10081 (China); Zhang, X.-G., E-mail: xgz@ufl.edu [Department of Physics and Quantum Theory Project, University of Florida, Gainesville, Florida 32611 (United States); Center for Nanophase Materials Sciences and Computer Science and Mathematics Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831-6493 (United States)

    2014-12-14

    Classical magnetoresistance (MR) in nonmagnetic metals are conventionally understood in terms of the Kohler rule, with violation usually viewed as anomalous electron transport, in particular, as evidence of non-Fermi liquid behavior. Measurement of the MR of Au films as a function of temperature and film thickness reveals a strong dependence on grain size distribution and clear violation of the Kohler rule. Using a model of random resistor network, we show that this result can be explained if the MR arises entirely from inhomogeneity due to grain boundary scattering and thermal activation of grain boundary atoms. Consequently, the Kohler rule should not be used to distinguish normal and anomalous electron transport in solids.

  15. Cytotoxic/natural killer cell cutaneous lymphomas. Report of EORTC Cutaneous Lymphoma Task Force Workshop.

    NARCIS (Netherlands)

    Santucci, M.; Pimpinelli, N; Massi, D; Kadin, ME; Meijer, C.J.L.M.; Muller-Hermelink, HK; Paulli, M; Wechsler, J.; Willemze, R.; Audring, H; Bernengo, MG; Cerroni, L.; Chimenti, S.; Chott, A.; Diaz-Perez, J.L.; Dippel, E; Duncan, LM; Feller, AC; Geerts, M.L.; Hallermann, C; Kempf, W; Russell-Jones, R; Sander, C; Berti, E.

    2003-01-01

    BACKGROUND: Cutaneous lymphomas expressing a cytotoxic or natural killer (NK) cell phenotype represent a group of lymphoproliferative disorders for which there is currently much confusion and little consensus regarding the best nomenclature and classification. METHODS: This study analyzes 48 cases

  16. Dans quelle mesure peut-on faire face au manque de motivation dans l'apprentissage de l'anglais au gymnase chez les élèves bilingues ?

    OpenAIRE

    Taguchi, Lina; Zahnd, Joëlle; Thonhauser, Ingo

    2016-01-01

    Ce travail de mémoire traite des élèves bilingues et de leur relation d'apprentissage avec l'anglais au gymnase. A travers une démarchede recherche-action, nous examinons une piste afin de développer la motivation et l'intérêt de ces élèves.L'analyse de questionnaires complétés par écrit par nos élèves bilingues indique que leur niveau d'anglais leur permet d'obtenir des notes suffisantes et qu'ils ne veulent pas fournir d'efforts dans cette branche. Ils admettent certes pouvoir améliorer leu...

  17. Sequelles de Brulures au Centre Hospitalier Universitaire Ibn Rochd de Casablanca: Aspects Epidemio-Cliniques

    Science.gov (United States)

    Chafiki, N.; Fassi Fihri, J.; Boukind, E.H.

    2007-01-01

    Summary Il s'agit d'une étude épidémiologique des séquelles de brûlures à propos de 100 cas colligés au service de chirurgie réparatrice et de brûlés du centre hospitalier universitaire Ibn Rochd (Casablanca). Les adultes représentent 55% de la population étudiée, l'âge moyen global est de 20 ans. Le sexe féminin est le plus touché avec 61% des cas. Les brûlures survenues à domicile sont les plus fréquentes avec 80%. L'agent causal le plus incriminé est la petite bouteille de butane avec 44,4%. Plus de la moitié de la population brûlée (55%) sont accueillis initialement au niveau d'hôpitaux régionaux. Le délai de cicatrisation moyen de 7 mois et 11 jours et par conséquent les séquelles mineures (dyschromie dans 90% des cas et prurit dans 49% des cas) et majeures (rétractions dans 86% et l'hypertrophie dans 51%) sont fréquentes. La répartition globale des séquelles montre une prédominance du segment cervicocéphalique avec 89% des cas et des membres supérieurs dans 82% des cas. Les différents aspects anatomocliniques essentiels ont été décrits au niveau de chaque segment corporel. Nos résultats ont été comparés aux données de la littérature, ce qui nous amène à considérer qu'une large campagne de prévention couplée à une meilleure prise en charge initiale, précoce, bien conduite et multidisciplinaire permet non seulement de réduire le nombre de séquelles mais aussi de diminuer leur sévérité. PMID:21991060

  18. Cutaneous Manifestations in POEMS Syndrome: Case Report and Review

    Directory of Open Access Journals (Sweden)

    Flauberto Sousa Marinho

    2015-04-01

    Full Text Available The authors report a case of sensorimotor polyneuropathy, diffuse cutaneous hyperpigmentation, skin sclerodermiform thickening and papular lesions in the infraclavicular and abdominal region. Besides weight loss, there were diabetes mellitus and hypothyroidism. The alterations were consistent with POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy and Skin changes syndrome, which is a rare systemic disease with monoclonal proliferation of plasmacytes and slow progression. Cutaneous alterations are present in 68% of patients with diffuse cutaneous hyperpigmentation, plethora and acrocyanosis. Leukonychia, necrotizing vasculitis, hypertrichosis and cutaneous thickening of sclerodermiform type are also cited. The onset of multiple cutaneous angiomas in this syndrome has been observed in 24-44% of patients.

  19. Cutaneous leiomyosarcoma arising in a smallpox scar

    NARCIS (Netherlands)

    Pol, Robert A.; Dannenberg, Hilde; Robertus, Jan-Lukas; van Ginkel, Robert J.

    2012-01-01

    Background: Cutaneous leiomyosarcoma (CLM) is a very rare smooth muscle tumour that accounts for about 2-3% of all superficial soft tissue sarcomas. Although the development of various malignancies in scar tissue is well known, we report the first case of a CLM developing in a small pox scar. Case

  20. Epidemiological studies on cutaneous leishmaniasis in Ad ...

    African Journals Online (AJOL)

    Farahmand M, Nahrevanian H, Shirazi HA, Naeimi S,. Farzanehnejad Z. An overview of a diagnostic and epidemiologic reappraisal of cutaneous leishmaniasis in. Iran. Braz J Infect Dis 2011; 15(1): 17-21. 12. Bousslimi N, Aoun K, Ben-Abda I, Ben-Alaya-Bouafif N,. Raouane M, Bouratbine A. Epidemiologic and clinical.

  1. Fibromodulin Enhances Angiogenesis during Cutaneous Wound Healing

    Directory of Open Access Journals (Sweden)

    Zhong Zheng, PhD

    2014-12-01

    Conclusions: Altogether, we demonstrated that in addition to reducing scar formation, FMOD also promotes angiogenesis. As blood vessels organize and regulate wound healing, its potent angiogenic properties will further expand the clinical application of FMOD for cutaneous healing of poorly vascularized wounds.

  2. Value of diagnostic techniques for cutaneous leishmaniasis

    NARCIS (Netherlands)

    Faber, William R.; Oskam, Linda; van Gool, Tom; Kroon, Nel C. M.; Knegt-Junk, Kristine J.; Hofwegen, Henk; van der Wal, Allard C.; Kager, Piet A.

    2003-01-01

    Background: Traditional diagnostic tests, ie, smear, Culture, and histopathology of a skin biopsy specimen, are not always Conclusive in patients with a clinical diagnosis of cutaneous leishmaniasis (CL). Objective: Our purpose was to find out if a polymerase chain reaction (PCR) specific for

  3. Primary Cutaneous Aspergillosis in an Immunocompetent Patient

    African Journals Online (AJOL)

    Case report and review of the literature. Paediatric Dermatol 2002;19: 439-44. 7. Prasad PV, Babu A, Kaviarasan PK, Anadhi C, Viswanathan P. Primary cutaneous aspergillosis. Indian J Dermatol Verner Leprol 2005;71:133-4. 8. Edlich RF, Winters KL, Britt LD, Long WD, Gubler KD, Drake DB. Difficult wounds: An update.

  4. Disseminated cutaneous histoplasmosis with laryngeal involvement ...

    African Journals Online (AJOL)

    Conclusion: We present this case to remind clinicians that disseminated histoplasmosis in AIDS patients may occur as an expression of IRIS. A sudden onset of hoarseness with cutaneous lesions in a patient with disseminated disease should alert one to possible laryngeal histoplasmosis. Prompt recognition and treatment ...

  5. A rapidly enlarging cutaneous hemangioma in pregnancy

    Directory of Open Access Journals (Sweden)

    Marwan Ma’ayeh

    2014-10-01

    Full Text Available This is a case of a rapidly enlarging cutaneous pedunculated tumor on a patient’s thumb during her pregnancy. This was excised and identified as a hemangioma. A literature search identified a possible hormonal factor in causing an accelerated growth of this tumor.

  6. Accidental injuries and cutaneous contaminations during general ...

    African Journals Online (AJOL)

    Conclusion: This study has demonstrated that cutaneous, percutaneous, and mucous membrane exposure to patients blood and body fluids are common events during general surgical operations. Most accidental injuries were due to solid suture needle-sticks, mostly injured personnel were the primary operating surgeons, ...

  7. Cutaneous myiasis due to Dermatobia hominis.

    Science.gov (United States)

    Hohenstein, E J; Buechner, S A

    2004-01-01

    Cutaneous myiasis caused by the human botfly Dermatobia hominis involves the infestation of tissue with dipterous fly larvae and is common in the neotropical region of the New World. We report a case of D. hominis imported in Switzerland from Costa Rica. In the past, various approaches to extract the botfly larva have been reported. Copyright 2004 S. Karger AG, Basel

  8. [Female patient with cutaneous anthrax in Belgium

    NARCIS (Netherlands)

    Gyssens, I.C.J.; Weyns, D.; Kullberg, B.J.; Ursi, J.P.

    2001-01-01

    A 23-year-old Turkish woman was admitted with an infection of the left thumb. The clinical picture was typical for cutaneous anthrax. Microbiological tests confirmed the diagnosis 'infection by Bacillus anthracis'. She recovered when treated with penicillin, although later tests revealed that the

  9. A rapidly enlarging cutaneous hemangioma in pregnancy.

    LENUS (Irish Health Repository)

    Ma'ayeh, Marwan

    2014-06-18

    This is a case of a rapidly enlarging cutaneous pedunculated tumor on a patient\\'s thumb during her pregnancy. This was excised and identified as a hemangioma. A literature search identified a possible hormonal factor in causing an accelerated growth of this tumor.

  10. Mefloquine in the treatment of cutaneous leishmaniasis

    Directory of Open Access Journals (Sweden)

    Correia Dalmo

    1999-01-01

    Full Text Available Three cases of cutaneous leishmaniasis were treated orally with a mefloquine dose of 4.2mg/kg/day for six days in the Teaching Hospital of the Faculdade de Medicina do Triângulo Mineiro, Uberaba, MG, Brazil. Three weeks later a new series was repeated. No patient was cured.

  11. Clinicopathological and molecular aspects of cutaneous Melanoma

    NARCIS (Netherlands)

    Bogenrieder, T.

    2009-01-01

    Clinicopathological and molecular aspects of cutaneous melanoma. Melanoma arises form the transformation of neural crest-derived melanocytes, the pigment cells of the skin, which reside in the basal layer of the epidermis. Melanoma is the deadliest form of skin cancer and one of the most aggressive

  12. Cutaneous biology and diseases of fish.

    Science.gov (United States)

    Groff, J M

    2001-05-01

    The normal structure and function of the piscine integument reflects the adaptation of the organism to the physical, chemical, and biological properties of the aquatic environment, and the natural history of the organism. Because of the intimate contact of fish with the environment, cutaneous disease is relatively more common in fish than in terrestrial vertebrates and is one of the primary disease conditions presented to the aquatic animal practitioner. However, cutaneous lesions are generally nonspecific and may be indicative of disease that is restricted to the integument or a manifestation of systemic disease. Regardless, a gross and microscopic examination of the integument is simple to perform, but is highly diagnostic and should always be included in the routine diagnostic effort of the aquatic animal practitioner, especially since various ancillary diagnostic procedures are either not practical or lack predictive value in fish. The purpose of this article is to provide an overview of normal cutaneous biology prior to consideration of specific cutaneous diseases in fish.

  13. Treating cutaneous aging with patented technologies

    Indian Academy of Sciences (India)

    Anti-aging; cosmeceuticals; cutaneous aging; patents; skin. Author Affiliations. Wing-Fu Lai1 Marie C Lin2. Department of Mechanical Engineering, The University of Hong Kong, Hong Kong Special Administrative Region, China; Shenzhen Key Laboratory of Translational Medicine of Tumor, School of Medicine, Shenzhen ...

  14. Fine needle aspiration cytology diagnosis of cutaneous ...

    African Journals Online (AJOL)

    We report a case of cutaneous sporotrichosis diagnosed on fine needle aspiration cytology. The cytologic findings had features which included presence of fungal elements compatible with Sporothrix morphology that allowed a correct diagnosis in our case. It is concluded that the FNA cytology of sporotrichosis is ...

  15. Case report

    African Journals Online (AJOL)

    abp

    16 janv. 2013 ... Abstract. La pathomimie cutanée se définit comme une maladie factice, provoquée dans un etat de conscience claire par le patient lui-même, au niveau du revêtement cutanéo-muqueux et/ou des phanères. Rare chez l'enfant, il s'agit d'une manifestation psychopathologique potentiellement grave et.

  16. Cutaneous anthrax in Southeast Anatolia of Turkey.

    Science.gov (United States)

    Tekin, Recep; Sula, Bilal; Devecı, Ozcan; Tekin, Alicem; Bozkurt, Fatma; Ucmak, Derya; Kaya, Şafak; Bekcibasi, Muhammed; Erkan, Mehmet Emin; Ayaz, Celal; Hosoglu, Salih

    2015-03-01

    Anthrax is a rare disease cause by Bacillus anthracis, a Gram-positive, rod-shaped endospore-forming capsuled bacterium. Anthrax is manifest in three primary forms: cutaneous, respiratory, and gastrointestinal. Cutaneous anthrax accounts for approximately 95% of all cases of anthrax in humans. In the present study, we evaluated the clinical diagnosis and treatment of cutaneous anthrax, a rare disease that nonetheless remains a serious healthcare problem in developing countries. The complete medical records of patients diagnosed with cutaneous anthrax between January 2001 and December 2012 were examined in a retrospective manner. Cutaneous anthrax was diagnosed by the identification of typical anthrax lesions and/or the presence of Gram-positive-capsuled bacillus after staining with Gram stain and methylen blue in pathology samples obtained from these lesions and the presence of characteristic scarring with a history of severe swelling, black eschar, and positive response to treatment form the basis of diagnosis in cases where cultures were negative for the presence of bacillus. A total of 58 patients were admitted to the hospital with cutaneous anthrax between January 2001 and December 2012. This included 32 (55.2%) males and 26 (44.8%) females, with an age range of 15-82 years and a mean age of 38 ± 13.8 years. The incubation period for the infection ranged between 1 and 20 d (mean 3.7 ± 1.4 d). The most common symptoms at the time of hospital referral were swelling, redness, and black eschar of the skin. The most common lesion site was the hand and fingers (41.3%). Isolated of bacteria was used to diagnose the disease in six cases (23.8%), detection of Gram-positive bacillus in samples of characteristic lesion material was used in seven (28.5%) cases, and the presence of a characteristic lesion was the sole diagnostic criteria in 45 (77.6%) cases. Treatment consisted of penicillin G (12 cases), ampicillin-sulbactam (30 cases), Cefazolin (12 cases), or

  17. Multifragmentation in Au + Au collisions studied with AMD-V

    Energy Technology Data Exchange (ETDEWEB)

    Ono, Akira [Tohoku Univ., Sendai (Japan). Faculty of Science

    1998-07-01

    AMD-V is an optimum model for calculation of multifragmentation in Au + Au collisions. AMD-V consider anti-symmetry of incident nucleus, target nucleus and fragments, furthermore, it treat the quantum effect to exist many channels in the intermediate and final state. 150 and 250 MeV/nucleon incident energy were used in the experiments. The data of multifragment atom in {sup 197}Au + {sup 197}Au collisions was reproduced by AMD-V calculation using Gognny force, corresponding to the imcompressibility of nuclear substance K = 228 MeV and its mean field depend on momentum. When other interaction (SKG 2 force, corresponding to K = 373 KeV) was used an mean field does not depend on momentum, the calculation results could not reproduce the experimental values, because nucleus and deuteron were estimated too large and {alpha}-particle and intermediate fragments estimated too small. (S.Y.)

  18. An overview of the cutaneous porphyrias.

    Science.gov (United States)

    Dawe, Robert

    2017-01-01

    This is an overview of the cutaneous porphyrias. It is a narrative review based on the published literature and my personal experience; it is not based on a formal systematic search of the literature. The cutaneous porphyrias are a diverse group of conditions due to inherited or acquired enzyme defects in the porphyrin-haem biosynthetic pathway. All the cutaneous porphyrias can have (either as a consequence of the porphyria or as part of the cause of the porphyria) involvement of other organs as well as the skin. The single commonest cutaneous porphyria in most parts of the world is acquired porphyria cutanea tarda, which is usually due to chronic liver disease and liver iron overload. The next most common cutaneous porphyria, erythropoietic protoporphyria, is an inherited disorder in which the accumulation of bile-excreted protoporphyrin can cause gallstones and, rarely, liver disease. Some of the porphyrias that cause blistering (usually bullae) and fragility (clinically and histologically identical to porphyria cutanea tarda) can also be associated with acute neurovisceral porphyria attacks, particularly variegate porphyria and hereditary coproporphyria. Management of porphyria cutanea tarda mainly consists of visible-light photoprotection measures while awaiting the effects of treating the underlying liver disease (if possible) and treatments to reduce serum iron and porphyrin levels. In erythropoietic protoporphyria, the underlying cause can be resolved only with a bone marrow transplant (which is rarely justifiable in this condition), so management consists particularly of visible-light photoprotection and, in some countries, narrowband ultraviolet B phototherapy. Afamelanotide is a promising and newly available treatment for erythropoietic protoporphyria and has been approved in Europe since 2014.

  19. An overview of the cutaneous porphyrias

    Science.gov (United States)

    Dawe, Robert

    2017-01-01

    This is an overview of the cutaneous porphyrias. It is a narrative review based on the published literature and my personal experience; it is not based on a formal systematic search of the literature. The cutaneous porphyrias are a diverse group of conditions due to inherited or acquired enzyme defects in the porphyrin–haem biosynthetic pathway. All the cutaneous porphyrias can have (either as a consequence of the porphyria or as part of the cause of the porphyria) involvement of other organs as well as the skin. The single commonest cutaneous porphyria in most parts of the world is acquired porphyria cutanea tarda, which is usually due to chronic liver disease and liver iron overload. The next most common cutaneous porphyria, erythropoietic protoporphyria, is an inherited disorder in which the accumulation of bile-excreted protoporphyrin can cause gallstones and, rarely, liver disease. Some of the porphyrias that cause blistering (usually bullae) and fragility (clinically and histologically identical to porphyria cutanea tarda) can also be associated with acute neurovisceral porphyria attacks, particularly variegate porphyria and hereditary coproporphyria. Management of porphyria cutanea tarda mainly consists of visible-light photoprotection measures while awaiting the effects of treating the underlying liver disease (if possible) and treatments to reduce serum iron and porphyrin levels. In erythropoietic protoporphyria, the underlying cause can be resolved only with a bone marrow transplant (which is rarely justifiable in this condition), so management consists particularly of visible-light photoprotection and, in some countries, narrowband ultraviolet B phototherapy. Afamelanotide is a promising and newly available treatment for erythropoietic protoporphyria and has been approved in Europe since 2014. PMID:29152226

  20. Clinical characteristics of cutaneous lupus erythematosus

    Directory of Open Access Journals (Sweden)

    Justyna Szczęch

    2016-02-01

    Full Text Available Introduction : Lupus erythematosus (LE shows a wide variety of clinical manifestations, skin involvement being one of the most important. Aim : To analyze the clinical presentation of cutaneous variants of lupus erythematosus in terms of skin lesion spectrum and extracutaneous involvement. Material and methods : A total of 64 patients with cutaneous LE (CLE were included. The study was based on the “Core Set Questionnaire” developed by the European Society of Cutaneous Lupus Erythematosus (EUSCLE. Clinical severity of skin lesions was evaluated with the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI. All results were subjected to statistical analysis. Results : Fifteen (23.4% patients had an acute CLE (ACLE, 26 (40.6% subacute CLE (SCLE and 21 (32.8% chronic CLE (CCLE. Two (3.2% individuals only demonstrated urticarial vasculitis as a cutaneous manifestation of LE and these patients were excluded. Patients with ACLE were characterized by the earliest onset of the disease (mean age of 31.9 ±15.0 years; p < 0.001. On average, 4.8 ±1.8 criteria of systemic LE were found in the ACLE group compared to 2.7 ±1.3 criteria in SCLE and 2.5 ±1.5 criteria in CCLE (p < 0.001. The highest activity of skin lesions according to CLASI was found in the SCLE group (p = 0.002. On the other hand, the most severe skin damage was observed in CCLE (p < 0.01. Conclusions : Each variant of CLE differs significantly from the others in respect of various aspects of clinical manifestations. Due to a number of different variants of LE skin lesions, a unified classification of CLE still remains a challenge.

  1. C'est simple quand j'y réfléchis! L'impact du nombre d'informations visuelles présentées sur un pack en fonction du niveau de charge cognitive

    OpenAIRE

    Fanny Thomas; Sonia Capelli

    2015-01-01

    International audience; Cette étude porte sur les perceptions des consommateurs d’un packaging en fonction de son niveau de simplicité et de la charge cognitive. Le niveau de simplicité a été manipulé via le nombre d'ingrédients représentés sur un packaging de produit alimentaire. Une expérimentation (n = 216) between subject, réalisée sous charge cognitive et sans charge cognitive, met en évidence deux voies par lesquelles le nombre d'ingrédients impacte l’attitude envers le packaging. Premi...

  2. Le soi à l’épreuve de la retraite sportive de haut niveau : de la nécessité d’un remaniement identitaire

    OpenAIRE

    Navel, Aurélie

    2011-01-01

    Introduction  Le sport de haut niveau appelle à l’investissement et l’engagement intenses dans un environnement singulier, focalisé sur les performances physiques, parfois aseptisé de toute interférence extérieure susceptible de brouiller les ondes de l’excellence motrice et ainsi la compromettre. C’est dans cette nébuleuse à la fois particulière et protectrice que vit et se vit l’athlète de haut niveau (parfois dès le plus jeune âge), formatant ainsi une partie de son identité sur la base de...

  3. Café au lait macules and juvénile polyps.

    Science.gov (United States)

    Pacheco, Theresa R; Scatena, Lisa S; Hoffenberg, Edward J; Gralla, Jane; Lee, Lela A

    2007-01-01

    Several hereditary and nonhereditary gastrointestinal tract polyposis syndromes exhibit extra-intestinal manifestations, including cutaneous findings. However, a lack of information exists regarding cutaneous features of juvenile polyposis. Our objective was to document the prevalence of cutaneous hyperpigmented lesions in children with juvenile polyposis coli or juvenile polyposis coli and their first degree relatives.Children seen in the gastroenterology practice at The Children's Hospital in Denver, Colorado with polyps (juvenile polyposis coli, sporadic juvenile polyps, and familial adenomatous polyposis coli) and their first degree relatives were invited to participate in the study. A comprehensive skin examination was performed on those who consented to participate. We found that 8 of 14 patients (eight with juvenile polyposis coli, four with juvenile polyposis, and two with familial adenomatous polyposis coli) had at least one café-au-lait macule, compared with three of 27 relatives (p=0.003).The prevalence of at least one café-au-lait macule in our patients (8/14 or 57.1%, CI: 28.9–82.3%) was significantly higher than the general population prevalence of 28.5% (p=0.023). However, if the two patients with familial adenomatous polyposis coli were excluded, the comparison with the general population prevalence did not reach statistical significance (p=0.095). The prevalence of multiple cafe´-au-lait macules in our patients (4/14 or 28.6%; CI:8.4–58.1%) was significantly higher than the general population prevalence of 5.2% (p ¼ 0.005). A notable finding was the presence of multiple café -au-lait macules in 4 of 12 juvenile polyposis coli/juvenile polyposis patients.Two patients with juvenile polyposis coli also had lentigines. In this selected case series, we observed single or multiple café-au-lait macules in a high proportion of children with the three types of polyps. Further studies are needed to assess a possible common pathway for hamartomatous

  4. Face au risque

    CERN Document Server

    Grosse, Christian; November, Valérie

    2007-01-01

    Ce volume collectif sur le risque inaugure la collection L'ÉQUINOXE. Ancré dans l'histoire pour mesurer les continuités et les ruptures, il illustre la manière dont les sciences humaines évaluent et mesurent les enjeux collectifs du risque sur les plans politiques, scientifiques, énergétiques, juridiques et éthiques. Puisse-t-il nourrir la réflexion sur la culture et la prévention du risque. Ses formes épidémiques, écologiques, sociales, terroristes et militaires nourrissent les peurs actuelles, structurent les projets sécuritaires et constituent - sans doute - les défis majeurs à notre modernité. Dans la foulée de la richesse scientifique d'Equinoxe, L'ÉQUINOXE hérite de son esprit en prenant à son tour le pari de contribuer - non sans risque - à enrichir en Suisse romande et ailleurs le champ éditorial des sciences humaines dont notre société a besoin pour forger ses repères. Après Face au risque suivra cet automne Du sens des Lumières. (MICHEL PORRET Professeur Ordinaire à la F...

  5. Chiral magnetic effect search in p+Au, d+Au and Au+Au collisions at RHIC

    Science.gov (United States)

    Zhao, Jie; STAR Collaboration

    2017-09-01

    The chiral magnetic effect (CME) is a fundamental property of QCD. A major background source for CME measurements is the intrinsic particle correlations (such as resonances/jets decay) coupled with the azimuthal elliptical anisotropy v2. In heavy-ion collisions, the magnetic field direction and event plane azimuthal angle Ψ2 are correlated, thus the CME and the v2-induced background are entangled. In small system p+Au and d+Au collisions, the Ψ2 is mostly due to geometry fluctuations, and thus magnetic field direction and Ψ2 are uncorrelated. The correlation measurements in small system collisions with respect to Ψ2 are only sensitive to v2-induced background while any CME is averaged to zero. In this talk, we will present the STAR measurements of two-particle correlations with respect to Ψ2 in p+Au, d+Au and Au+Au collisions at √{sNN} = 200 GeV. These results are analyzed as a function of particle multiplicity to shed light on the background contaminations of the CME measurements in heavy-ion collisions. We will also report results from a new analysis approach as a function of the particle pair invariant mass in order to suppress non-CME related physics backgrounds.

  6. The immune microenvironment in cutaneous leishmaniasis.

    Science.gov (United States)

    Jabbour, M N; Issa, G; Charafeddine, K; Simaan, Y; Karam, M; Khalifeh, H; Habib, R; Khalifeh, I

    2015-06-01

    Cutaneous leishmaniasis is an infection that has spread to non-endemic regions, stimulating recent interest for the enhanced understanding of this disease. Downregulation of the CD1a receptor on Langerhans cells has been described in various cutaneous infections. In this study, the immune response across different Ridley patterns and parasitic indices is outlined in a case series of cutaneous leishmaniasis. Skin punch biopsies from the interface of normal and lesional cutaneous leishmaniasis were collected from 33 patients with molecularly confirmed Leishmania tropica or L. major infection. Ridley patterns (2-5) were assessed for various clinicopathological features including age, gender, disease duration, parasitic index and constituents of the inflammatory infiltrate. CD1a, CD68, CD3, CD4, CD8, CD20 and CD138 stains were performed on normal skin tissue, cutaneous leishmaniasis biopsies and cytospin/cell block cytology preparations of cultured leishmania promastigotes. CD1a was quantified per mm2 in the epidermis and dermis. The remaining stains were graded according to a 4-tiered grading system [0 (0-4%); 1 (5-24%); 2 (25-49%); 3 (50-74%) and 4 (75-100%). Total CD1a expression significantly decreased (14-fold) from parasitic indices (0-2) to (5-6); (ρ < 0.001). CD1a expression in the epidermis was at least 5-fold lower than normal skin (58 vs. 400 cells/mm2), inversely correlating with the parasitic index. There was an increase in dermal CD1a Langerhans cells (33 vs. 0 cells/mm² in the dermis). CD1a and CD68 staining of amastigotes was strong and diffuse, whereas promastigotes were negative. The major inflammatory infiltrate, in all Ridley patterns, consisted of macrophages and double-negative CD3(+) CD4(-) CD8(-) T lymphocytes. The double-negative CD3 T cells formed a ring around the parasitic laden macrophages. Apart from CD1a, there was no significant difference in inflammatory markers between the various Ridley patterns and parasitic indices. Disease

  7. SOX-10 expression in cutaneous myoepitheliomas and mixed tumors.

    Science.gov (United States)

    Naujokas, Agne; Charli-Joseph, Yann; Ruben, Beth S; Yeh, Iwei; LeBoit, Philip E; McCalmont, Timothy H; Pincus, Laura B

    2014-04-01

    SOX-10 expression can be demonstrated by immunohistochemistry in salivary gland myoepitheliomas, but its expression in cutaneous myoepitheliomas and in cutaneous mixed tumors with prominent myoepithelial cells has not been studied. We assessed the staining pattern of SOX-10 in five cutaneous myoepitheliomas and six cutaneous mixed tumors with a prominent myoepithelial component among both the myoepithelial cells and cells lining lumens. In addition, we examined the staining of S100, microphthalmia-associated transcription factor (MiTF), keratin cocktail, HMK903, smooth muscle actin (SMA) and epithelial membrane antigen (EMA). SOX-10 positivity was seen in three of five (60%) cutaneous myoepitheliomas and in the myoepithelial cells of all cutaneous mixed tumors. SOX-10 expression on the cells lining the glandular structures in mixed tumors was variable. All myoepitheliomas and mixed tumors stained positively with S100 and negatively with MiTF. Pan-keratin, HMK903, SMA and EMA showed variable expression. SOX-10 is a relatively reliable marker for staining cutaneous myoepitheliomas. Cutaneous myoepitheliomas are notoriously difficult to diagnose, and the addition of SOX-10 to the repertoire of stains that can label this tumor is of practical utility. These results further support that cutaneous myoepitheliomas and cutaneous mixed tumors exist on a morphologic and immunophenotypic spectrum. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  8. Verrucous cutaneous sarcoidosis: case report and review of this unusual variant of cutaneous sarcoidosis.

    Science.gov (United States)

    Stockman, David L; Rosenberg, Jason; Bengana, Chafik; Suster, Saul; Plaza, Jose A

    2013-04-01

    Sarcoidosis is a multisystem disorder of unknown origin, characterized by the accumulation of lymphocytes and mononuclear histiocytes inducing the formation of noncaseating "naked" epithelioid granulomas. The lungs, lymphatic system, and skin are most often affected, but sarcoidosis may affect any organ. Cutaneous involvement of sarcoidosis is often the sentinel sign of the disease, with the skin sometimes being exclusively affected. We present a case of a 54-year-old African American woman with long-standing history of pulmonary sarcoidosis that presented with multiple verrucous cutaneous lesions on the upper and lower extremities mimicking carcinoma. The initial cutaneous biopsy was superficial in nature, and the pathologist raised the consideration of a possible keratoacanthoma. A deeper skin shave biopsy was performed, and the histopathology showed verrucous pseudoepitheliomatous epidermal hyperplasia with scattered noncaseating granulomas in the superficial dermis. Stains (acid-fast bacillus, Periodic acid-Schiff, and Gomori-Grocott methenamine silver stains) were negative for microorganisms. Given the clinical setting and histomorphology of the cutaneous lesions, the diagnosis of verrucous sarcoidosis was rendered. Verrucous sarcoidosis is a rare cutaneous manifestation of sarcoidosis that could be easily misdiagnosed if it is not appropriately biopsied. This hinders the precise evaluation of the histological specimen, overall clinical picture, and administration of appropriate therapy.

  9. Angiogenesis in cutaneous disease: part I.

    Science.gov (United States)

    Nguyen, Amy; Hoang, Van; Laquer, Vivian; Kelly, Kristen M

    2009-12-01

    Angiogenesis is an important process in normal physiology and disease pathogenesis. Angiogenesis is controlled in a healthy body by a system of angiogenic growth factors and angiogenesis inhibitors. When angiogenic growth factors are predominantly expressed, blood vessel growth occurs and disease may result. Successful therapies have been developed that target growth factors, their receptors, or the cascade pathways that are activated by growth factor/receptor interactions. There is good evidence that angiogenesis plays an important role in a wide range of cutaneous maladies, and angiogenesis-targeting therapies are playing an increasing role in the management of dermatologic disease. Cutaneous angiogenesis offers an exciting new arena for targeted dermatologic therapeutics. After completing this learning activity, participants should be able to distinguish angiogenic growth factors and inhibitors, recognize angiogenic mediating agents and compare their mechanisms of action, and apply the use of angiogenic mediating agents in clinical and research situations.

  10. Cutaneous embolism of an atrial myxoma.

    Science.gov (United States)

    Rodríguez Bandera, Ana Isabel; Stewart, Nicholas Charles; Uribe, Pablo; Minocha, Rashi; Choi, James Young Joon

    2015-08-01

    Cardiac myxoma often presents with heterogeneous symptoms and signs and represents a challenging diagnosis. The cutaneous manifestations, if present, are often transient and non-specific and the clinician must possess a high degree of suspicion to secure the diagnosis. We present the case of a 36-year-old woman with a 6-month history of intermittent, painful, violaceous, non-blanching macules on the thumb and fingertips of the left hand and right ankle. A cutaneous embolic phenomenon was suspected and an urgent echocardiogram demonstrated an atrial mass, with subsequent histopathology confirming the clinical suspicion of atrial myxoma. Early diagnosis and excision of the tumour avoided serious complications. © 2015 The Australasian College of Dermatologists.

  11. [Cutaneous myiasis--a vacation souvenir].

    Science.gov (United States)

    Frieling, U; Nashan, D; Metze, D

    1999-03-01

    Cutaneous myiasis is a temporary infestation of the skin with fly larvae. Travelling to subtropical areas accounts for a higher risk and increasing incidence in Europeans. In Middle- and South American myiasis is mainly caused by the botfly (Dermatobia hominis). Blood-suckling arthropods, usually mosquitoes, transmit the larvae of the botfly via phoresis, a unique mechanism of egg deposition. In Africa cutaneous myiasis is mostly due to the tumbu fly (Cordylobia anthropophaga). Infection with the tumbu fly larvae occurs after direct contact with the eggs that are often deposited in clothes and towels. Clinically an abscess-like lesion develops. Creeping sensations of movement under the skin are occasionally described. Following hatching, spontaneous healing can normally be expected, although extraction of the larvae is recommended to prevent abscess formation and superinfection.

  12. Lessons from Cancer Immunoediting in Cutaneous Melanoma

    Directory of Open Access Journals (Sweden)

    Mariana Aris

    2012-01-01

    Full Text Available We will revisit the dual role of the immune system in controlling and enabling tumor progression, known as cancer immunoediting. We will go through the different phases of this phenomenon, exposing the most relevant evidences obtained from experimental models and human clinical data, with special focus on Cutaneous Melanoma, an immunogenic tumor per excellence. We will describe the different immunotherapeutic strategies employed and consider current models accounting for tumor heterogeneity. And finally, we will propose a rational discussion of the progress made and the future challenges in the therapeutics of Cutaneous Melanoma, taking into consideration that tumor evolution is the resulting from a continuous feedback between tumor cells and their environment, and that different combinatorial therapeutic approaches can be implemented according to the tumor stage.

  13. American cutaneous leishmaniasis in infancy and childhood.

    Science.gov (United States)

    Paniz-Mondolfi, Alberto E; Talhari, Carolina; García Bustos, María F; Rosales, Tamara; Villamil-Gomez, Wilmer E; Marquez, Marilianna; Pérez Alvarez, Alexandra M; Tálamo Sánchez, Alejandra I; Rodriguez-Morales, Alfonso J

    2017-12-01

    Infant and young child skin diseases are among the most common features of morbidity throughout the tropics. Because the skin is directly exposed to the environment, it is considerably affected by climatic and local conditions such as vectors and microorganisms, as in the case of leishmaniasis. In America the observed magnitude of cutaneous leishmaniasis in children has led to the study of increased risk of exposure of this group due to the possibility of peri- and intradomiciliary transmission. The present review pretends to make a concrete approach all through the broad and main figures of this parasitic disease, including the clinical, physiopathological, epidemiological, diagnostic, and therapeutic aspects, in order to be used as a practical source of reference for pediatricians leading with tropical cutaneous pathology in the region. © 2017 The International Society of Dermatology.

  14. Ofloxacin Induced Cutaneous Reactions in Children.

    Science.gov (United States)

    Ramani, Yerramalli Roja; Mishra, Sailen Kumar; Rath, Bandana; Rath, Saroj Sekhar

    2015-06-01

    Cutaneous adverse effects to antimicrobials are a major health problem. Though majority of them are mild and self-limiting, severe variants like Steven Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN) are not uncommon. Ofloxacin, a fluoroquinolone widely used for the treatment of urinary tract infections, acute bacterial diarrheas, enteric fever, STDs and other soft tissue infections either as a single drug or in combination with other drugs. Earlier a case of mucocutaneous maculopapular rash with oral ofloxacin and was reported in an adult. In the present hospital set up there were few reports of such reactions to adults. Here we report three different variants of reactions associated with oral ofloxacin in chlidren. Early detection of cutaneous lesions and immediate withdrawal of the offending drug can prevent progression of such reactions to their severe variants as well as morbidity and mortality.

  15. Drug-induced cutaneous lupus erythematosus

    DEFF Research Database (Denmark)

    Laurinaviciene, Rasa; Holm Sandholdt, Linda; Bygum, Anette

    2017-01-01

    BACKGROUND: An increasing number of drugs have been linked to drug-induced subacute cutaneous lupus erythematosus (DI-SCLE). The recognition and management of DI-SCLE can be challenging, as the condition may be triggered by different classes of drugs after variable lengths of time. OBJECTIVES......: To determine the proportion of patients with cutaneous lupus erythematosus (CLE) whose drugs are an inducing or aggravating factor. MATERIALS & METHODS: We conducted a retrospective chart review of patients diagnosed with CLE at a dermatological department over a 21-year period. We registered clinical......, serological, and histological data with a focus on drug intake. RESULTS: Of 775 consecutive patients with a diagnosis of lupus erythematosus (LE) or suspected LE, a diagnosis of CLE could be confirmed in 448 patients. A total of 130 patients had a drug intake that could suggest DI-SCLE. In 88 cases, a drug...

  16. Cutaneous porphyrias part II: treatment strategies.

    Science.gov (United States)

    Tintle, Suzanne; Alikhan, Ali; Horner, Mary E; Hand, Jennifer L; Davis, Dawn Marie R

    2014-01-01

    The porphyrias are diverse in pathophysiology, clinical presentation, severity, and prognosis, presenting a diagnostic and therapeutic challenge. Although not easily curable, the dermatological manifestations of these diseases, photosensitivity and associated cutaneous pathology, can be effectively prevented and managed. Sun avoidance is essential, and patient education regarding the irreversibility of photocutaneous damage is a necessary corollary. Beyond preventative measures, the care of fragile, vulnerable skin, and pain management, each of the porphyrias has a limited number of unique additional therapeutic options. Many of the treatments have been published only in small case series or anecdotal reports and do not have well-understood nor proven mechanisms of action. This article presents a comprehensive review of available therapeutic options and long-term management recommendations for the cutaneous porphyrias. © 2013 The International Society of Dermatology.

  17. Secondary Cutaneous Amyloidosis Associated with Mycosis Fungoides

    Science.gov (United States)

    2018-02-16

    34" Secondary localized cutaneous amyloidosis is often not clinically apparent, but may be seen histologically.lt is associated with several skin ...wood’s lamp, the lesions did not fluoresce. The differential diagnosis included morphea. hypopigmcnted mycosis fungoidcs. post-inflammatory...It is associated with several skin tumors, and has been reported with PUVA use. To date, there are three reported cases of secondary localized

  18. Radiology in cutaneous sinuses and fistulae

    Energy Technology Data Exchange (ETDEWEB)

    Sundgren-Borgstroem, P.; Ekberg, O.; Lasson, A.

    1988-12-01

    In patients with cutaneous openings, sinograph and fistulography an usually performed. Fistulae in the head/neck region and perineum are seldom life-threatening while enterocutaneous fistulae involving the small bowel can be a serious threat due to loss of fluid. Radiology contributes to the preoperative examination of these patients. Fistulography outlines communications to the gastrointestinal tract, pleura, joints and other underlying crucial structures. Involved bowel segments are further demonstrated with barium examination.

  19. Assessment of cutaneous drug delivery using microdialysis

    DEFF Research Database (Denmark)

    Kreilgaard, Mads

    2002-01-01

    technique for cutaneous drug delivery assessments. Firstly, the technique is currently not suitable for sampling of highly lipophilic compounds and, secondly, more studies are desirable for elucidation of the variables associated with the technique to increase reproducibility. The present literature...... indicates that the condition of the skin at the individual assessment sites is the main variable, but also variables associated with relative recovery, differentiation between the pharmacokinetic parameters (i.e., lag time, distribution, absorption and elimination rate) can influences the reproducibility...

  20. Cutaneous Manifestations of Systemic Lupus Erythematosus

    OpenAIRE

    Uva, Luís; Miguel, Diana; Pinheiro, Catarina; Freitas, João Pedro; Marques Gomes, Manuel; Filipe, Paulo

    2012-01-01

    Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease of unknown etiology with many clinical manifestations. The skin is one of the target organs most variably affected by the disease. The American College of Rheumatology (ACR) established 11 criteria as a classificatory instrument to operationalise the definition of SLE in clinical trials. They were not intended to be used to diagnose individuals and do not do well in that capacity. Cutaneous lesions account for four of these...

  1. Prevalence of hypopigmented maculae and café-au-lait spots in idiopathic epileptic and healthy children.

    Science.gov (United States)

    Karabiber, Hamza; Sasmaz, Sezai; Turanli, Guzide; Yakinci, Cengiz

    2002-01-01

    The cutaneous lesions and findings related to the central nervous system are frequently seen concomitantly in many patients. Neurocutaneous syndromes are the most typical examples supporting this observation. The prevalences of hypopigmented maculae and café-au-lait spots were investigated in 210 idiopathic epileptic children between the ages of 2 and 17 years and 2754 healthy children between the ages of 5 and 15 years. In the group of epileptic children, hypopigmented maculae and café-au-lait spots were observed in 30 (14.3%) and 63 (30%) children, respectively. In the group of healthy children, the prevalence of hypopigmented maculae was 1.6% (44 children) and of café-au-lait spots was 2.83% (78 children). The difference between the two groups was very significant statistically (P < .0001).

  2. CRYOSURGERY FOR TREATMENT OF CUTANEOUS WARTS

    Directory of Open Access Journals (Sweden)

    I Made Bagus Adhi Paramitha

    2013-02-01

    Full Text Available Minor surgery is a general surgical procedure that applied with minimally invasive procedures and short duration, done in a superficial or just the affected tissue.  This technique is normally only requires a local anaesthetic and only has minimal  risk or complications. There are many cases that could be dealt with minor surgery one is veruka. Veruka or known as cutaneous warts is a disease that is often complained in children and adults. Veruka being estimated to occur until over 10% in children and young adults. Largest incident occurred in range of age 12 to 16 years. Veruka occurs more frequently in women than men. The peak incidence occur of age 13 years on women and 14.5 years in males. Salicylic acid and cryosurgery therapy are two of the most frequently performed in the treatment of cutaneous warts. Salicylic acid is therapy  for cutaneous warts who recently had already started replaced by cryosurgery because it is relatively easy to do and faster recovery.  

  3. Cutaneous EBV-related lymphoproliferative disorders.

    Science.gov (United States)

    Gru, Alejandro A; Jaffe, Elaine S

    2017-01-01

    This article will focus on the cutaneous lymphoproliferative disorders associated with EBV, with an emphasis on the upcoming changes in the revised 4th Edition of the WHO classification of tumors of the hematopoietic system, many of which deal with cutaneous disorders derived from NK-cells or T-cells. Extranodal NK/T-cell lymphoma usually presents in the upper aerodigestive tract, but can involve the skin secondarily. EBV-associated T- and NK-cell lymphoproliferative disorders (LPD) in the pediatric age group include the systemic diseases, chronic active EBV infection (CAEBV) and systemic EBV+ T-cell lymphoma of childhood. Hydroa vacciniforme (HV)-like LPD is a primarily cutaneous form of CAEBV and encompasses the lesions previously referred to as HV and HV-like lymphoma (HVLL). All the T/NK-cell-EBV-associated diseases occur with higher frequency in Asians, and indigenous populations from Central and South America and Mexico. Among the B-cell EBV-associated LPD two major changes have been introduced in the WHO. The previously designated EBV-positive diffuse large B-cell lymphoma (EBV-DLBCL) of the elderly, has been changed to EBV-DLBCL with 'not otherwise specified' as a modifier (NOS). A new addition to the WHO system is the more recently identified EBV+ mucocutaneous ulcer, which involves skin and mucosal-associated sites. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Cutaneous leiomyosarcoma arising in a smallpox scar

    Science.gov (United States)

    2012-01-01

    Background Cutaneous leiomyosarcoma (CLM) is a very rare smooth muscle tumour that accounts for about 2–3% of all superficial soft tissue sarcomas. Although the development of various malignancies in scar tissue is well known, we report the first case of a CLM developing in a small pox scar. Case presentation A 66-year-old man presented with a painless, slow-growing lump in a small pox scar on his left shoulder. Histological biopsies showed the lesion to be a primary, well-differentiated cutaneous leiomyosarcoma. A CT scan of the thorax was conducted, which showed no signs of metastases. The complete lesion was then surgically excised, and histopathological examination revealed a radically excised cutaneous type leiomyosarcoma After 13 months’ review the patient was doing well with no evidence of tumour recurrence. Conclusions This is the first report of a CLM arising in a small pox scar. Although the extended time interval between scarring and malignant changes makes it difficult to advise strict follow-up for patients with small pox scars, one should be aware that atypical changes and/or symptoms occurring in a small pox scar could potentially mean malignant transformation. PMID:22799750

  5. Infiltrative Cutaneous Hemangiolipoma in a Goat

    Directory of Open Access Journals (Sweden)

    Jessica R. Collier

    2013-01-01

    Full Text Available An approximately 4-year-old castrated male, Saanen cross goat presented to the Colorado State University Veterinary Teaching Hospital for evaluation and removal of a 22 cm × 22 cm, dark red, thickened, and crusted cutaneous lesion along the left ventrolateral thorax. An initial incisional biopsy performed approximately 8 weeks earlier was suspicious for cutaneous hemangiosarcoma. Surgical excision was deemed to be the most appropriate treatment option for this goat. A complete physical exam, complete blood count, and chemistry profile were performed and results were within normal limits. Thoracic radiographs and abdominal ultrasound were performed to rule out metastatic disease and comorbid conditions; no metastatic lesions or other abnormalities were observed. En bloc surgical excision of the affected skin was performed and the entire tissue was submitted for histopathology. A final diagnosis of cutaneous hemangiolipoma was reached upon extensive sectioning and histologic examination of the larger tissue specimen. The goat recovered well from surgery and has had no further complications up to 9 months postoperatively. To our knowledge, this is the first case report of a hemangiolipoma in a goat and surgical excision for such lesions appears to be a viable treatment method.

  6. Diagnostic Immunohistochemistry in Cutaneous Neoplasia: An Update

    Directory of Open Access Journals (Sweden)

    Leigh A. Compton

    2015-04-01

    Full Text Available Immunohistochemistry (IHC is an important adjunct in the diagnosis of neoplastic skin diseases. In addition to the many established IHC markers currently in use, new markers continue to emerge, although their general acceptance and routine application requires robust validation. Here, we summarize the most well-established and commonly used biomarkers along with an array of newer ones reported in the past several decades that either demonstrate or hold high clinical promise in the field of cutaneous pathology. We also highlight recent applications of novel IHC markers in melanoma diagnosis including genetic mutation status markers [e.g. BRAF (v-raf murine sarcoma viral oncogene homolog B and NRAS (neuroblastoma RAS viral oncogene homolog] and an epigenetic alteration marker (e.g. 5-hydroxymethylcytosine. We specifically focus on the role of IHC in the differential diagnosis of cutaneous lesions that fall under the following categories: melanoma, epidermal tumors with an intraepidermal epitheliomatous pattern, spindle cell lesions of the dermis, small round blue cell tumors of the dermis, and cutaneous adnexal tumors. While IHC is a valuable tool in diagnostic dermatopathology, marker selection and interpretation must be highly informed by clinical context and the histologic differential diagnosis. With rapid progress in our understanding of the genetic and epigenetic mechanisms of tumorigenesis, new IHC markers will continue to emerge in the field of diagnostic dermatopathology.

  7. Discoveries and controversies in cutaneous mosaicism.

    Science.gov (United States)

    Castori, Marco; Tadini, Gianluca

    2016-06-01

    Genetic mosaicism is thought to be a common phenomenon in inherited skin disorders. It is the leading molecular mechanism explaining cutaneous hamartomas and nevoid disorders, skin manifestations of most X-linked genodermatoses and specific forms of clinical variability and topographic distribution in autosomal skin disorders. The developmental (in utero) origin and timing dependence are two major attributes for the current definition of cutaneous mosaicism. Chromosomal mosaicism, lyonization in X-linked genodermatoses, and various types of mosaicism (i.e. type 1, type 2 and revertant mosaicism) in autosomal skin disorders are mechanisms well defined at the molecular level. All these concepts have been fully included in the current medical terminology in dermatology and genetics. Mitotic crossing-over, paradominant inheritance, monoallelic expression of autosomal traits and mosaicism in acquired skin disorders remain without a formal molecular proof and still represent sources of debate in the scientific community. This review summarizes current concepts, discoveries and controversies in the field of cutaneous mosaicism for practitioners and clinical researchers to enhance their understanding of such a underestimated clinical phenomenon and its biological basis.

  8. Cutaneous hemophagocytosis: Clinicopathologic features of 21 cases.

    Science.gov (United States)

    Boggio, Francesca; Lora, Viviana; Cota, Carlo; Pereira, Amanda; Müllegger, Robert; Prieto-Torres, Lucia; Cerroni, Lorenzo

    2018-02-01

    Hemophagocytosis is well known in cytotoxic cutaneous T-cell lymphomas (CTCLs), in which it may represent a sign of hemophagocytic lymphohistiocytosis syndrome (HLHS), and is also typical of cutaneous Rosai-Dorfman disease (cRDD) (without prognostic relevance). Only rarely, has cutaneous hemophagocytosis (CH) been described in other skin conditions. To characterize the clinicopathologic features of CH in skin biopsy specimens from patients with conditions other than CTCL or cRDD. Case series analyzing clinicopathologic features and follow-up data on patients presenting with histopathologic signs of CH. Biopsy specimens from 21 patients were included. None of the patients had HLHS. The majority (n = 11) presented with leukocytoclastic vasculitis. Other associated diseases were lupus erythematous (n = 2), arthropod bite reaction (n = 2), erysipelas (n = 1), acne conglobata (n = 1), and Sweet syndrome (n = 1). Three patients had a nonspecific rash concomitant with Chlamydia pneumonia, middle ear infection, and pharyngitis, respectively. This was a single-center, retrospective study. Isolated CH in conditions other than CTCL and cRDD is a histopathologic finding related mostly to leukocytoclastic vasculitis. Extensive investigations should be performed only if patients have other signs or symptoms of HLHS. Copyright © 2017 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  9. A Therapeutic update on Cutaneous leishmaniasis.

    Science.gov (United States)

    Bari, Arfan Ul; Rahman, Simeen Ber

    2003-08-01

    Leishmaniasis, in its visceral (VL), cutaneous (CL) and mucocutaneous (MCL) forms, directly affects hundreds of thousands people per annum, with millions of individuals at risk worldwide. Cutaneous leishmaniasis (CL) is an infective skin disease that manifests as ulcerated nodules, upto several centimeters in size, which are quite resistant to treatment. A wide variety of therapeutic modalities have been employed for cutaneous leishmaniasis. However, none has been demonstrated to be good enough as the first-line therapeutic agent to treat patients in all the epidemiological scenarios. Although pentavalent antimonials are widely used in the treatment of all forms of leishmaniasis, the response is far from satisfactory. These must be administered parenterally with occurrence of therapeutic failures. Secondary treatments incorporate amphotericin B, which is highly active but its use is limited by extensive toxicity complications and high cost. Several oral drugs, such as pentamidine, ketoconazole and itraconazole, have also been tested. Results obtained are not entirely satisfactory. The majority of topical agents have been tested in non-controlled studies, with only few subjects. The interpretation of results is usually difficult due to the lack of a standard and well-accepted cure definition. There remains a pressing need for new anti-leishmanials. This review is focused upon the current status of chemotherapy, the various avenues being investigated by researchers and their potential application in the future.

  10. Cutaneous leiomyosarcoma arising in a smallpox scar.

    Science.gov (United States)

    Pol, Robert A; Dannenberg, Hilde; Robertus, Jan-Lukas; van Ginkel, Robert J

    2012-07-16

    Cutaneous leiomyosarcoma (CLM) is a very rare smooth muscle tumour that accounts for about 2-3% of all superficial soft tissue sarcomas. Although the development of various malignancies in scar tissue is well known, we report the first case of a CLM developing in a small pox scar. A 66-year-old man presented with a painless, slow-growing lump in a small pox scar on his left shoulder. Histological biopsies showed the lesion to be a primary, well-differentiated cutaneous leiomyosarcoma. A CT scan of the thorax was conducted, which showed no signs of metastases. The complete lesion was then surgically excised, and histopathological examination revealed a radically excised cutaneous type leiomyosarcoma After 13 months' review the patient was doing well with no evidence of tumour recurrence. This is the first report of a CLM arising in a small pox scar. Although the extended time interval between scarring and malignant changes makes it difficult to advise strict follow-up for patients with small pox scars, one should be aware that atypical changes and/or symptoms occurring in a small pox scar could potentially mean malignant transformation.

  11. Cutaneous leiomyosarcoma arising in a smallpox scar

    Directory of Open Access Journals (Sweden)

    Pol Robert A

    2012-07-01

    Full Text Available Abstract Background Cutaneous leiomyosarcoma (CLM is a very rare smooth muscle tumour that accounts for about 2–3% of all superficial soft tissue sarcomas. Although the development of various malignancies in scar tissue is well known, we report the first case of a CLM developing in a small pox scar. Case presentation A 66-year-old man presented with a painless, slow-growing lump in a small pox scar on his left shoulder. Histological biopsies showed the lesion to be a primary, well-differentiated cutaneous leiomyosarcoma. A CT scan of the thorax was conducted, which showed no signs of metastases. The complete lesion was then surgically excised, and histopathological examination revealed a radically excised cutaneous type leiomyosarcoma After 13 months’ review the patient was doing well with no evidence of tumour recurrence. Conclusions This is the first report of a CLM arising in a small pox scar. Although the extended time interval between scarring and malignant changes makes it difficult to advise strict follow-up for patients with small pox scars, one should be aware that atypical changes and/or symptoms occurring in a small pox scar could potentially mean malignant transformation.

  12. Anterior cutaneous nerve entrapment syndrome: management challenges

    Directory of Open Access Journals (Sweden)

    Chrona E

    2017-01-01

    Full Text Available Eleni Chrona,1,2 Georgia Kostopanagiotou,1 Dimitrios Damigos,3 Chrysanthi Batistaki1 1Second Department of Anesthesiology, School of Medicine, National and Kapodistrian University of Athens, “Attikon” Hospital, Athens, 2Department of Anesthesiology, General Hospital of “Ag. Panteleimon,” Piraeus, 3Department of Medical Psychology, Medical School of Ioannina, University of Ioannina, Ioannina, Greece Abstract: Anterior cutaneous nerve entrapment syndrome (ACNES is a commonly underdiagnosed and undertreated chronic state of pain. This syndrome is characterized by the entrapment of the cutaneous branches of the lower thoracoabdominal intercostal nerves at the lateral border of the rectus abdominis muscle, which causes severe, often refractory, chronic pain. This narrative review aims to identify the possible therapeutic strategies for the management of the syndrome. Seventeen studies about ACNES therapy were reviewed; of them, 15 were case–control studies, case series, or case reports, and two were randomized controlled trials. The presently available management strategies for ACNES include trigger point injections (diagnostic and therapeutic, ultrasound-guided blocks, chemical neurolysis, and surgical ­neurectomy, in combination with systemic medication, as well as some emerging techniques, such as radiofrequency ablation and neuromodulation. An increased awareness of the syndrome and the use of specific diagnostic criteria for its recognition are required to facilitate an early and successful management. This review compiles the proposed ­management strategies for ACNES. Keywords: anterior cutaneous nerve entrapment syndrome, intercostal, neuralgia, management

  13. Cutaneous pancreatic metastasis: A case report and review of literature

    Directory of Open Access Journals (Sweden)

    Abdel Hafez H

    2008-01-01

    Full Text Available Pancreatic cancer is one of the most dangerous human cancers and will continue to be a major unsolved health problem as we enter the 21 st century. This is the case despite advances in imaging technology and surgical management. Indeed, 80% to 90% of pancreatic cancers are diagnosed either at the locally advanced or metastatic stage. Cutaneous metastases originating from pancreatic cancer are relatively rare. The most common site of cutaneous metastasis is the umbilicus, and this is known as the Sister Joseph′s nodule. Very few patients have been reported with cutaneous lesions disclosing a pancreatic carcinoma at sites other than the umbilical area. To the best of our knowledge, there have been no previous reports on cutaneous pancreatic metastasis in Egypt. This is a report on a patient with cutaneous pancreatic metastases at the neck and review of reported non-umbilical cutaneous metastases from pancreatic carcinoma in the literatures.

  14. Orofacial cutaneous function in speech motor control and learning

    OpenAIRE

    Ito, Takayuki

    2015-01-01

    International audience; Somatosensory signals from facial skin can provide a rich source of sensory input. However, it is unknown yet how cutaneous input works on speech motor control and learning. This chapter introduces a kinesthetic role of orofacial cutaneous afferents in speech processing. We argue for specificity of the orofacial somatosensory system from anatomical and physiological perspectives. The contribution of cutaneous afferents to speech production is evident in neurophysiologi...

  15. Primary Cutaneous Mantle Cell Lymphoma: A Case Report

    Directory of Open Access Journals (Sweden)

    L. D. Mazzuoccolo

    2013-01-01

    Full Text Available Primary cutaneous mantle cell lymphoma (MCL is a rare cutaneous proliferation of naive pregerminal CD-5 positive B cells in the skin with no extracutaneous involvement. Overexpression of cyclin D1 is pathognomonic of this condition, and surgery and radiation therapy are the most common therapeutic options. In this case, we describe the clinical, histopathological, immunohistochemical, and molecular characteristics of a new case of primary cutaneous MCL.

  16. A case of cutaneous paragonimiasis presented with minimal pleuritis

    OpenAIRE

    Singh, T Shantikumar; Devi, KH Ranjana; Singh, S Rajen; Sugiyama, Hiromu

    2012-01-01

    Clinically, paragonimiasis is broadly classified into pulmonary, pleuropulmonary, and extrapulmonary forms. The common extrapulmonary forms are cerebral and cutaneous paragonimiasis. The cutaneous paragonimiasis is usually presented as a slowly migrating and painless subcutaneous nodule. The correct diagnosis is often difficult or delayed or remained undiagnosed until the nodule becomes enlarged and painful and the cause is investigated. We report here a case of cutaneous paragonimiasis in a ...

  17. Sonography of the Primary Cutaneous Melanoma: A Review

    Directory of Open Access Journals (Sweden)

    Ximena Wortsman

    2012-01-01

    Full Text Available The diagnosis and management of primary cutaneous melanoma have traditionally relied on clinical and histological characteristics. Nevertheless, in recent years there has been a significant growth in the usage of ultrasound for studying the cutaneous layers. Thus, the present paper focuses on the primary lesion, its sonographic characteristics, the potential benefits of early imaging, and the new developments on the ultrasound field applied to cutaneous melanoma.

  18. Novel Low-Cost Thermotherapy for Cutaneous Leishmaniasis in Peru

    OpenAIRE

    Valencia, Braulio M.; Miller, David; Witzig, Richard S.; Boggild, Andrea K.; Llanos-Cuentas, Alejandro

    2013-01-01

    Author Summary American cutaneous leishmaniasis is an endemic parasitic disease in Peru, with more than a reported thousand cases per year associated with significant disabilities and economic impact. In comparison to old-world cutaneous Leishmaniasis where the infection generally heals on its own, American cutaneous Leishmaniasis is a chronic skin disease and its treatment can be expensive, difficult to administer, and associated with significant adverse events. We developed a heat treatment...

  19. Borophene synthesis on Au(111)

    Science.gov (United States)

    Guisinger, Nathan; Kiraly, Brian; Zhang, Zhuhua; Mannix, Andrew; Hersam, Mark C.; Yakobson, Boris I.

    The recent experimental discovery of borophene, the metallic 2-dimensional allotrope of boron, has sparked tremendous interest in further exploration of this unique material. The initial synthesis of borophene was accomplished on Ag substrates and serves as a quintessential example of predictive modeling to experimental realization. In this talk, we expand the phase-space of borophene synthesis to Au. Borophene synthesis was accomplished by evaporating elemental boron onto a Au(111) substrate. The synthesized borophene retains its metallic character on Au as verified with scanning tunneling spectroscopy. Most fascinating is the difference in growth dynamics on the Au(111) substrate where the reconstructed surface presents a unique energy landscape for borophene nucleation and growth. We find that the initial low-coverage growth of borophene modifies the herringbone reconstruction into a ``trigonal'' network, where the 2D boron islands are uniformly templated across the surface. Increasing coverage results in the increasing size of the templated borophene islands until they coalesce into larger sheets. The observed growth dynamics are supported by the computational modeling of boron nucleation on Au.

  20. L’apprentissage au cern

    CERN Multimedia

    2007-01-01

    pour les professions d’électronicien(ne) et de laborantin(e) en physique L’apprentissage au CERN est régi par les lois, règlements et contrats en vigueur dans le canton de Genève. En cas de réussite à l’examen de fin d’apprentissage, les apprentis obtiennent le Certificat fédéral de capacité suisse (CFC). 6 places au total sont ouvertes au recrutement pour les deux professions. L’apprentissage dure 4 ans. Minima requis pour faire acte de candidature : avoir au moins 15 ans et moins de 21 ans à la date de début de l’apprentissage ; avoir terminé la scolarité obligatoire, au minimum 9e du Cycle d’orientation genevois (3e en France) ; être ressortissant d’un pays membre du CERN (Allemagne, Autriche, Belgique, Bulgarie, Danemark, Espagne, Finlande, France, Grèce, Hongrie, Italie, Norvège, Pays-Bas, Pologne, Portugal, Royaume-Uni, République tchèque, République slovaque , Suède, Suisse) ; pour les résidents en Suisse : être ressortissant su...

  1. Transverse Velocity Scaling in Au+Au Fragmentation

    OpenAIRE

    Lukasik, J.; Hudan, S.; Lavaud, F.; Turzo, K.; Auger, G.; Bacri, Ch.O.; Begemann-Blaich, M.L.; Bellaize, N.; Bittiger, R.; Bocage, F.; Borderie, B.; Buchet, P.; R. Bougault(LPCC); Bouriquet, B.; Charvet, J. L.

    2002-01-01

    Invariant transverse-velocity spectra of intermediate-mass fragments were measured with the 4-pi multi-detector system INDRA for collisions of Au on Au at incident energies between 40 and 150 MeV per nucleon. Their scaling properties as a function of incident energy and atomic number Z are used to distinguish and characterize the emissions in (i) peripheral collisions at the projectile and target rapidities, and in (ii) central and (iii) peripheral collisions near mid-rapidity. The importance...

  2. Gender disparity between cutaneous and non-cutaneous manifestations of Lyme borreliosis.

    Directory of Open Access Journals (Sweden)

    Franc Strle

    Full Text Available Cutaneous manifestations of Lyme borreliosis in Europe include erythema migrans (EM and acrodermatitis chronica atrophicans (ACA; the most common non-cutaneous manifestations are Lyme neuroborreliosis (LNB and Lyme arthritis. The purpose of this study was to evaluate the gender distribution of patients with these clinical manifestations of Lyme borreliosis. Data on gender were obtained from the clinical records of patients with Lyme borreliosis aged ≥15 years who had been evaluated at the University Medical Center Ljubljana, Ljubljana, Slovenia. Among 10,539 patients diagnosed with EM, 6,245 (59.3% were female and among 506 ACA patients 347 (68.6% were female. In contrast, among the 60 patients with Lyme arthritis only 15 (25% were female (p<0.0001 for the comparison of gender with EM or ACA and among the 130 patients with LNB only 51 (39.2% were females (p<0.0001for the comparison of gender with EM or ACA. Although the proportion that was female in the LNB group was greater than that of patients with Lyme arthritis, this difference did not reach statistical significance (p = 0.10. Although older individuals are more likely to be female in the general Slovenian population, the age of patients with cutaneous versus non-cutaneous manifestations was not the explanation for the observed differences in gender. In conclusion, patients with cutaneous manifestations of Lyme borreliosis were predominantly female, whereas those with non-cutaneous manifestations were predominantly male. This provocative finding is unexplained but may have direct relevance to the pathogenesis of Lyme borreliosis.

  3. Incidental finding of cutaneous meningeal heterotopia in aplasia cutis congenita.

    Science.gov (United States)

    Kenyon, Katharine; Zedek, Daniel; Sayed, Christopher

    2016-07-01

    Aplasia cutis congenita and cutaneous meningeal heterotopia are both rare congenital conditions that most commonly occur on the scalp and may appear clinically and histologically similar. A subtype of aplasia cutis congenita, membranous aplasia cutis congenita, and cutaneous meningeal heterotopia are both proposed to result from neural tube closure errors. However, neither non-membranous nor membranous aplasia cutis congenita are known to occur together with cutaneous meningeal heterotopia in the same lesion. We report the incidental finding of cutaneous meningeal heterotopia within a lesion of aplasia cutis congenita. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  4. Cutaneous metastasis of breast adenoid cystic carcinoma to the scalp.

    Science.gov (United States)

    Little, Anthony J; Seline, Alison E; Swick, Brian L; Wanat, Karolyn A

    2016-08-01

    Adenoid cystic carcinoma (ACC) is a tumor that can be of primary cutaneous origin or secondary to metastatic disease, most commonly salivary origin. Aside from primary cutaneous and salivary types, ACC of the breast is a rare, more indolent variant. Cutaneous metastases secondary to breast ACC is exceedingly uncommon and not previously reported to our knowledge. We present the case of a 67-year-old woman who developed cutaneous metastasis from primary breast ACC. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  5. [Role of high-definition and high frequency ultrasonography in determining tumor thickness in cutaneous malignant melanoma].

    Science.gov (United States)

    Solivetti, F M; Thorel, M F; Di Luca Sidozzi, A; Bucher, S; Donati, P; Panichelli, V

    1998-12-01

    We investigated the predictive capabilities of high frequency, high resolution ultrasound (US) in the preoperative assessment of tumor thickness in cutaneous malignant melanomas. This evaluation is a valuable help for correct surgical planning. December 1997 to August 1998, we studied with US over 120 pigmented skin lesions and collected the data, including the final histologic diagnosis, of 78 of them, which make our series. Sixty-six of 78 lesions were histologically defined as cutaneous malignant melanomas with superficial spread and the other 12 as melanocytic nevi. All examinations were carried out with an Esaotebiomedica AU 5 Harmonic scanner equipped with a 20-MHz annular array probe and a linear 13-MHz probe; B-mode, color and power Doppler images were always acquired. The statistical analysis of the comparative US and histologic measurements of tumor thickness showed very good agreement, with a high Pearson's coefficient (R: .93). However, US frequently underestimated the actual thickness relative to histology, which is in contradiction with previous literature reports. We could study with US the melanoma in situ, which has never been described before. Last but not least, low-thickness melanomas had very few color and power Doppler signals. US is the correct tool for the preoperative assessment of the thickness of cutaneous malignant melanomas because it provides high agreement with histologic data even in lesions thinner than 1 mm.

  6. Multiscale Modeling of Au-Island Ripening on Au(100

    Directory of Open Access Journals (Sweden)

    Karin Kleiner

    2011-01-01

    Full Text Available We describe a multiscale modeling hierarchy for the particular case of Au-island ripening on Au(100. Starting at the microscopic scale, density functional theory was used to investigate a limited number of self-diffusion processes on perfect and imperfect Au(100 surfaces. The obtained structural and energetic information served as basis for optimizing a reactive forcefield (here ReaxFF, which afterwards was used to address the mesoscopic scale. Reactive force field simulations were performed to investigate more diffusion possibilities at a lower computational cost but with similar accuracy. Finally, we reached the macroscale by means of kinetic Monte Carlo (kMC simulations. The reaction rates for the reaction process database used in the kMC simulations were generated using the reactive force field. Using this strategy, we simulated nucleation, aggregation, and fluctuation processes for monoatomic high islands on Au(100 and modeled their equilibrium shape structures. Finally, by calculating the step line tension at different temperatures, we were able to make a direct comparison with available experimental data.

  7. Adjustment of a direct method for the determination of man body burden in Pu-239 on by X-ray detection of U-235; Mise au point d'une methode directe de determination de la charge corporelle en plutonium 239 chez l'homme par detection X de l'uranium 235

    Energy Technology Data Exchange (ETDEWEB)

    Boulay, P. [Commissariat a l' Energie Atomique, Bruyeres-le-Chatel (France). Centre d' Etudes

    1968-04-01

    The use of Pu-239 on a larger scale sets a problem about the contamination measurement by aerosol at lung level. A method of direct measurement of Pu-239 lung burden is possible, thanks to the use of a large area window proportional counter. A counter of such pattern, has been especially carried out for this purpose. The adjustment of the apparatus allows an adequate sensibility to detect a contamination at the maximum permissible body burden level. Besides, a method for individual 'internal calibration', with a plutonium mock: the protactinium-233, is reported. (author) [French] L'utilisation a une echelle de plus en plus large du plutonium-239 pose un probleme de la mesure de la contamination par aerosol au niveau du poumon. Une methode de mesure directe de la charge pulmonaire en plutonium-239 est possible grace a l'utilisation d'un compteur proportionnel a fenetre de grande surface. Un compteur de ce type a specialement ete realise dans ce but. La mise au point de l'appareillage permet une sensibilite suffisante pour deceler une contamination au niveau de la Q.M.A (quantite maximale admissible). D'autre part, une methode 'd'etalonnage interne' de l'individu a l'aide d'un simulateur de plutonium, le protactinium-233, est decrite. (auteur)

  8. Au36(SPh)23 nanomolecules.

    Science.gov (United States)

    Nimmala, Praneeth Reddy; Dass, Amala

    2011-06-22

    A new core size protected completely by an aromatic thiol, Au(36)(SPh)(23), is synthesized and characterized by MALDI-TOF mass spectrometry and UV-visible spectroscopy. The synthesis involving core size changes is studied by MS, and the complete ligand coverage by aromatic thiol group is shown by NMR.

  9. Cutaneous drug hypersensitivity : Immunological and genetic perspective

    Directory of Open Access Journals (Sweden)

    Kisalay Ghosh

    2011-01-01

    Full Text Available Drug hypersensitivity is an unpredictable, immunologically mediated adverse reaction, clustered in a genetically predisposed individual. The role of "hapten concept" in immune sensitization has recently been contested by the "pharmacological interaction" hypothesis. After completion of the "human genome project" and with the availability of high-resolution genotyping, genetic susceptibility to hypersensitivity for certain drugs has been proved beyond doubt though the trend is ethnicity and phenotype dependent. Application of this newly acquired knowledge may reduce or abolish the morbidity and mortality associated with cutaneous drug hypersensitivity.

  10. Mesotherapy and cutaneous Mycobacterium fortuitum infection.

    Science.gov (United States)

    Difonzo, Elisa Margherita; Campanile, Grazia Lucia; Vanzi, Laura; Lotti, Lorena

    2009-06-01

    Cutaneous infections caused by Mycobacterium fortuitum usually are a complication of trauma or postsurgical wounds. A 41-year-old woman presented with numerous dusky red nodules, abscesses and sinuses on the right buttock and on the lateral surfaces of both thighs. The lesions developed at the injection sites of mesotherapy treatment. M. fortuitum was cultured from a biopsy specimen and purulent fluid drained from lesions. The lesions had cleared completely with ciprofloxacin 500 mg b.d. for 3 weeks, and then 250 mg b.d. for another 3 weeks. This case demonstrates the importance of suspecting mycobacterial etiology in patients with nodules and abscesses in the areas of mesotherapy treatment.

  11. Palmar Telangiectasias: A Cutaneous Sign for Smoking.

    Science.gov (United States)

    Levi, Assi; Shechter, Ronen; Lapidoth, Moshe; Enk, Claes D

    2017-12-07

    Telangiectasias are permanent dilations of blood capillaries which appear in a variety of medical conditions. Cutaneous palmar telangiectasias have been postulated to be associated with smoking. To determine whether a significant correlation exists between palmar telangiectasias and smoking habits. A total of 124 volunteers participated in this observational study by allowing physical evaluation of their palms and by completing a questionnaire. Palmar telangiectasias were found to be associated with current or past smoking. Neither age nor gender was found to be a co-contributor. Palmar telangiectasias were found to constitute highly specific and sensitive markers for prolonged smoking. © 2017 S. Karger AG, Basel.

  12. Protective immunity and vaccination against cutaneous leishmaniasis.

    Science.gov (United States)

    Okwor, Ifeoma; Mou, Zhirong; Liu, Dong; Uzonna, Jude

    2012-01-01

    Although a great deal of knowledge has been gained from studies on the immunobiology of leishmaniasis, there is still no universally acceptable, safe, and effective vaccine against the disease. This strongly suggests that we still do not completely understand the factors that control and/or regulate the development and sustenance of anti-Leishmania immunity, particularly those associated with secondary (memory) immunity. Such an understanding is critically important for designing safe, effective, and universally acceptable vaccine against the disease. Here we review the literature on the correlate of protective anti-Leishmania immunity and vaccination strategies against leishmaniasis with a bias emphasis on experimental cutaneous leishmaniasis.

  13. Protective Immunity and Vaccination Against Cutaneous Leishmaniasis

    Directory of Open Access Journals (Sweden)

    Ifeoma eOkwor

    2012-05-01

    Full Text Available Although a great deal of knowledge has been gained from studies on the immunobiology of leishmaniasis, there is still no effective vaccine against the disease. This strongly suggests that we still do not understand the factors that control and/or regulate the development and sustenance of anti-Leishmania immunity, particularly those associated with secondary (memory immunity. Such an understanding is critically important for designing effective vaccines against the disease. Here we review the literature on the correlate of protective anti-Leishmania immunity and vaccination strategies against leishmaniasis with a bias emphasis on experimental cutaneous leishmaniasis.

  14. Coagulation disorders and their cutaneous presentations: Pathophysiology.

    Science.gov (United States)

    Chang, Yunyoung; Dabiri, Ganary; Damstetter, Elizabeth; Baiyee Ebot, Emily; Powers, Jennifer Gloeckner; Phillips, Tania

    2016-05-01

    Hypercoagulable states are inherited or acquired predispositions to venous or arterial thromboses that are best understood in the context of the coagulation cascade. Dermatologists can play a critical role in diagnosing and treating patients with hypercoagulable states because cutaneous symptoms may be a presenting manifestation, thereby reducing morbidity and mortality related to these conditions. This review focuses on the epidemiology and pathophysiology of hypercoagulable states, while the accompanying article iterates the basic clinical features, diagnostic testing, and management of patients who have these conditions. Copyright © 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  15. Familial hypercholesterolemia with multiple cutaneous xanthomas

    Directory of Open Access Journals (Sweden)

    Reddy BSN

    2006-01-01

    Full Text Available An interesting episode of homozygous familial hypercholesterolemia affecting four children born to a consanguinous parents belonging to two different families is reported for its rarity. The patients had multiple cutaneous xanthomas including the characteristic xanthoma tendinosum, xanthoma interosseum, xanthoma tuberosum, and xanthelasma palpebrarum. Prominent corneal arcus juvenalis has been noted in three children. Gross elevation of serum levels of low density lipoprotein cholesterol (LDLc with normal values of triglycerides have been found in all patients. They have been prescribed medication with oral tablets of simvastatin and advised fat restricted diet and regular follow up in the clinic at periodic intervals.

  16. Recurrent cutaneous jellyfish eruptions without envenomation.

    Science.gov (United States)

    Månsson, T; Randle, H W; Mandojana, R M; Calton, G J; Burnett, J W

    1985-01-01

    Three patients exhibiting recurrent cutaneous eruptions induced by contact with jellyfish tentacles are presented. The recurrent eruptions appeared several days after the primary exposure without contact with any offending coelenterate. The principal species involved include Pelagia noctiluca, Physalia physalis and probably Lychnorhiza lucerna. These three cases, combined with an earlier similar report of recurrent lesions induced by Physalia physalis suggest that this phenomenon may be widespread. In two of the three cases, the secondary eruption was more severe than that occurring after the primary envenomation.

  17. Primary cutaneous plasmacytosis: Masquerading as hidradenitis suppurativa

    Directory of Open Access Journals (Sweden)

    Tarang Goyal

    2016-01-01

    Full Text Available Isolated cutaneous plasmacytosis (CP is a rare entity with few cases reported in world literature. CP masquerading as hidradenitis suppurativa like presentation is a unique case with some features differentiating it clinically from it which were further confirmed by histopathology and immunostaining. Our case showed hyperplasia of mature plasma cells and polyclonal hypergammaglobulinemia, immunostaining for CD138 positivity and kappa: lambda ratio more than 3:1. Extensive clinical and laboratory investigations failed to reveal any underlying pathology, presence of any underlying disease accompanying the hypergammaglobulinemia and/or plasma cell proliferation.

  18. Cutaneous Gnathostomiasis: A Case Report from Thailand

    Directory of Open Access Journals (Sweden)

    Sakunee Niranvichaiya

    2016-03-01

    Full Text Available Gnathostomiasis is transmitted to humans via ingestion of third-stage larva of genus Gnathostoma. Thailand is considered an endemic area for the disease. We reported a 65-year-old Thai male patient with clinical presentation of a small number of nodular migratory swellings on the face and neck. The histopathology of skin biopsy revealed parasitic material surrounded by eosinophil infiltration and fibrosis in deep dermis. Therefore, we were able to confirm diagnosis of cutaneous gnathostomiasis. After treatment with ivermectin followed by albendazole, the lesions still persisted; thus, surgical excision of lesions may be the necessary curative treatment.

  19. [Influence of anxiety in diverse cutaneous diseases].

    Science.gov (United States)

    Vargas Laguna, E; Peña Payero, M L; Vargas Márquez, A

    2006-12-01

    The objective of the current study is to determine the levels of anxiety in patients with dermatological diseases compared to healthy subjects and the degree of anxiety in the different cutaneous diseases. It is a descriptive study of a case series where 152 patients are selected, 20 of whom are healthy controls and the other 132 are patients that attend a Dermatology clinic. The patients are divided into 5 groups based on the cutaneous disorder for which they attend the clinic: chronic urticaria, acute urticaria, plaque psoriasis, atopic dermatitis, and a miscellaneous group (includes several diagnoses such as seborrheic keratosis, follow-up of multiple nevi, carcinomas...) where, a priori, anxiety does not influence these disorders. Spielberger State-Trait Anxiety Inventory (STAI) is administered to the participating subjects and the differences in State Anxiety Inventory (SAI) and Trait Anxiety Inventory (TAI) for the different groups are analyzed. Patients were asked to report any stressful event in the six months prior to the appearance of the disease that might have been a trigger, and they were also asked about history of psychiatric disorders or atopy. We observed significant differences in the means obtained in SAI and TAI in healthy subjects compared to patients. We obtained higher mean scores in SAI in patients diagnosed of atopic dermatitis, that were significant when compared with patients with chronic urticaria or other diseases. Forty-eight percent of patients with psoriasis and 38.89 % of patients with atopic dermatitis report a stressful event in the past six months compared to 11.54% of patients from the group with miscellaneous diseases and, additionally, patients with psoriasis and atopic dermatitis have the highest mean scores in the anxiety tests. Twenty-one percent of the 132 patients with cutaneous diseases report a history of psychiatric disorders, showing statistically significant higher mean scores in STAI. The findings show the

  20. Effect of UV irradiation on cutaneous cicatrices

    DEFF Research Database (Denmark)

    Due, Eva; Rossen, Kristian; Sorensen, Lars Tue

    2007-01-01

    The aim of this study was to examine the effect of ultraviolet (UV) irradiation on human cutaneous cicatrices. In this randomized, controlled study, dermal punch biopsy wounds served as a wound healing model. Wounds healed by primary or second intention and were randomized to postoperative solar UV...... postoperatively, UV-irradiated cicatrices healing by second intention: (i) were significantly pointed out as the most disfiguring; (ii) obtained significantly higher scores of colour, infiltration and cicatrix area; and (iii) showed significantly higher increase in skin-reflectance measurements of skin-pigmentation...

  1. Pitfalls in Cutaneous Melanoma Lymphatic Drainage.

    Science.gov (United States)

    Voinea, Silviu; Sandru, Angela; Gherghe, Mirela

    2016-01-01

    Sentinel node (SN) biopsy has become standard in staging of cutaneous melanoma. As skin lymphatic drainage is complex, preoperative empirical assessment of SN localization is virtually impossible. Therefore in order to identify all regional lymphatic basins corresponding to a specific primary tumor is mandatory to carry out preoperative lymphoscintigraphy. In this paper we present a clinical case that highlights the importance of identifying, biopsy and histological analysis of all SN in order to achieve a correct staging of the patient, followed by appropriate treatment according to the real clinical stage of the disease. Celsius.

  2. Case Report: Generalized Cutaneous Candidiasis in a Preterm ...

    African Journals Online (AJOL)

    Background Generalised cutaneous candidiasis is rare in the neonatal period. When it does occur there is a risk of disseminated disease, particularly in preterm infants. Method A case report of a preterm baby who developed extensive cutaneous candidiasis. Result A 45 day old product of 30 weeks gestation noticed to ...

  3. Organotypic in vitro models of human cutaneous squamous cell carcinoma

    NARCIS (Netherlands)

    Commandeur, Suzan

    2013-01-01

    Skin cancer is the most common type of cancer in fair-skinned populations. Cutaneous squamous cell carcinoma (SCC) comprises about 15% of all skin cancer diagnoses. Treatment associated with the high and rising prevalence of cutaneous SCC puts an increasingly high financial burden on society,

  4. Pattern of Cutaneous Metastases (Analysis of 50 Cases

    Directory of Open Access Journals (Sweden)

    S Tharskaram

    1986-01-01

    Full Text Available An analysis of 50 patients having cutaneous metastasis arising from various malignancies revealed that the primary tumours in men were carcinomas of the lung (14%, oesophagus (8% stomach (6% and melanoma (6%. The most common primary tumours in women, were carcinomas of the breast (20% ovary 18% lung (6%, and (4% The cutaneous

  5. A Survey Of Cutaneous Neoplasms Among Horses Used For ...

    African Journals Online (AJOL)

    A total of 314 Arab horses of ages ranging from 4 to 15 years were examined of which 35(11.2%) were Albino and 279(88.85%) were non albino horses. Nine horses (2.86%) were observed to have cutaneous neoplasm. Gross characteristics of the cutaneous neoplasm found were studied and some biopsy samples ...

  6. Acitretin for the management of generalized cutaneous lichen planus.

    Science.gov (United States)

    Vazirnia, Aria; Cohen, Philip R

    2014-09-16

    Lichen planus is an inflammatory disease that affects the skin, the oral mucosa, or both. Generalized cutaneous lichen planus may pose a therapeutic challenge for clinicians if the condition persists or flares after topical or systemic corticosteroid therapy. Acitretin, a systemic retinoid, can be considered a potential second-line treatment for patients with generalized cutaneous lichen planus. Herein, we describe a postmenopausal woman with generalized cutaneous lichen planus who was successfully treated with acitretin. A 58-year-old woman presented with generalized cutaneous lichen planus involving her upper and lower extremities as well as her lower back. After failing corticosteroid therapy, she was started on acitretin 20 mg/day, which was later increased to 30 mg/day. To review the literature on the use of acitretin in cutaneous lichen planus, we used the PubMed search engine and searched for the terms "acitretin" and "cutaneous lichen planus." Our patient had complete resolution of pruritus within one week of initiating acitretin 20 mg/day. After an increase in dose to 30 mg/day, the cutaneous lesions completely resolved over a 3-month period. There was no recurrence of disease as acitretin was tapered and discontinued. Generalized cutaneous lichen planus may pose a therapeutic challenge for the symptomatic relief of skin lesions. Topical and systemic corticosteroids are first-line treatments. In patients who fail corticosteroids, relapse after corticosteroid therapy, or have contraindications to corticosteroids, acitretin may be considered a potential second-line therapy.

  7. A histopathological analysis of cutaneous malignancies in a tropical ...

    African Journals Online (AJOL)

    Aim: To establish the prevalence of cutaneous malignancies in Zaria, Northern Nigeria. Method: This is a histopathological analysis of three hundred and eighty two cases of cutaneous malignancies seen and diagnosed in the department of Pathology, Ahmadu Bello University Teaching Hospital, Zaria from January 1991 to ...

  8. Cutaneous myiasis caused by Dermatobia hominis acquired in Jamaica.

    Science.gov (United States)

    Veraldi, S; Francia, C; Persico, M C; La Vela, V

    2009-12-01

    The authors describe a case of cutaneous myiasis caused by Dermatobia hominis in a 23-year-old Italian woman who contracted the infestation during a tour in Jamaica. The infestation was located on the back and was characterized clinically by a single inflammatory nodule. To our knowledge, this is the first case of cutaneous myiasis due to Dermatobia hominis acquired in Jamaica.

  9. Cutaneous Involvement of Hodgkin Lymphoma in a Child – Case ...

    African Journals Online (AJOL)

    Specific cutaneous involvement in Hodgkin Lymphoma is rare and has not been reported in the younger paediatric age group. We report a case of a ten year old girl who presented with specific cutaneous involvement, confirmed using immunohistochemical stains. Treatment with combination chemotherapy resulted in rapid ...

  10. Diffuse hepatic hemangioma with single cutaneous hemangioma: an alerting occurrence.

    Science.gov (United States)

    Al Tasseh, Faten; El-Khansa, Merna; Abd, Omran; Abdel Khalek, Anoir; El-Rifai, Nahida

    2017-06-01

    Screening of infants with five or more cutaneous infantile hemangiomas with abdominal ultrasound is often recommended. However, diffuse hepatic hemangioma can develop even in patients with single cutaneous hemangioma. This highlights the importance of physical examination and screening ultrasound in these patients.

  11. Diffuse hepatic hemangioma with single cutaneous hemangioma: an alerting occurrence

    OpenAIRE

    Al Tasseh, Faten; El?Khansa, Merna; Abd, Omran; Abdel Khalek, Anoir; El?Rifai, Nahida

    2017-01-01

    Key Clinical Message Screening of infants with five or more cutaneous infantile hemangiomas with abdominal ultrasound is often recommended. However, diffuse hepatic hemangioma can develop even in patients with single cutaneous hemangioma. This highlights the importance of physical examination and screening ultrasound in these patients.

  12. Cutaneous manifestations of malignant disease: A review | Legbo ...

    African Journals Online (AJOL)

    Internal malignancies can produce a wide range of cutaneous manifestations that are often neglected by clinicians. This review aims to increase the awareness of clinicians by highlighting the various cutaneous manifestations of common internal malignancies. Method: A review composed via Medline Internet search, ...

  13. Coinfection of cutaneous leishmaniasis and hiv infection | Lartey ...

    African Journals Online (AJOL)

    Cutaneous leishmaniasis has recently been discovered in some parts of Ghana. The case of an HIV infected patient presenting with cutaneous leishmaniasis at the Korle-Bu Teaching Hospital is discussed. The diagnosis of leishmaniasis was con-firmed by histology. Also highlighted is the fact that this is the first reported ...

  14. Cutaneous leishmaniasis in Sudan: an update | El Hassan ...

    African Journals Online (AJOL)

    Cutaneous leishmaniasis due to L.major is now endemic in many parts of the northern Sudan. In this up-date we discuss the clinical manifestations of cutaneous leishmaniasis, its diagnosis and treatment. The most common clinical forms are nodular, noduloulcerative and ulcerative lesions. Less common forms are ...

  15. The changing profile of cutaneous leishmaniasis agent in a central ...

    African Journals Online (AJOL)

    Cutaneous leishmaniasis in Iran is usually caused by Leishmania major or L. tropica. However, the direct examination or the cultures of biopsies for diagnosis are not very sensitive. The objective of this study was to identify the responsible species obtained from patients suspected of cutaneous leishmaniasis referred to the ...

  16. Disseminated Cutaneous Leishmaniasis in HIV positive patient - A ...

    African Journals Online (AJOL)

    Disseminated cutaneous leishmaniasis and HIV dual-infection is seldom reported. Leishmaniasis and HIV co-infection may intensify the immune defect and is the chief reason for atypical presentation and widespread progression of cutaneous leishmaniasis and its defiance to conventional therapy. Here we report a ...

  17. Isolation of Leishmania tropica from an Ethiopian cutaneous leishmaniasis patient

    NARCIS (Netherlands)

    Hailu, Asrat; Di Muccio, Trentina; Abebe, Tamrat; Hunegnaw, Mesfin; Kager, Piet A.; Gramiccia, Marina

    2006-01-01

    Cutaneous leishmaniasis (CL) in the Old World is caused mainly by three species of Leishmania: L. major, L. tropica and L. aethiopica, and sporadically by L. infantum and L. donovani. In Ethiopia, zoonotic cutaneous leishmaniasis, caused by L. aethiopica, is a major public health problem affecting

  18. Electrochemotherapy for large cutaneous recurrence of breast cancer

    DEFF Research Database (Denmark)

    Matthiessen, Louise Wichmann; Johannesen, Helle Hjorth; Hendel, Helle Westergren

    2012-01-01

    Cutaneous recurrences of breast cancer may cause considerable discomfort due to ulceration, oozing, and pain and can also be difficult to treat. Electrochemotherapy is a localised anticancer treatment using electric pulses to make cell membranes permeable, augmenting uptake of chemotherapeutic...... drugs, and thus enabling highly efficient tumour cell kill. This is the first systematic investigation of electrochemotherapy for larger cutaneous recurrences of breast cancer....

  19. Orbito-Maxillofacial Cutaneous Anthrax | Kamau | Annals of African ...

    African Journals Online (AJOL)

    Background: Cutaneous anthrax is a zoonotic disease that spreads to humans primarily through exposure to infected animals, animal products or spore infested soil. Microbiological identification of cutaneous anthrax may be obscured by previous antibiotic use. Thorough history and clinical examination is therefore ...

  20. Successful Treatment of Cutaneous Mucormycosis in a Young ...

    African Journals Online (AJOL)

    This article reports successful eradication of isolated cutaneous mucormycosis in a young poorly controlled type 1 diabetic patient with end-stage renal disease using a combination of systemic antifungal agents and aggressive surgical debridement. Keywords: Cutaneous Mucormycosis, Diabetic, Echinocandin, Fungal, ...

  1. Anatomic Variations in the Palmar Cutaneous Branch of the Median ...

    African Journals Online (AJOL)

    Dysesthesias due to palmar cutaneous branch of median nerve injuries infrequently follow carpal tunnel release surgeries. Objective: To determine the course of palmar cutaneous branch of the median nerve in wrist of adult Nigerians, identify the common variations, determine its relations to the palmaris longus (PL) in the ...

  2. Cutaneous lichen planus: A systematic review of treatments.

    Science.gov (United States)

    Fazel, Nasim

    2015-06-01

    Various treatment modalities are available for cutaneous lichen planus. Pubmed, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Database of Abstracts of Reviews of Effects, and Health Technology Assessment Database were searched for all the systematic reviews and randomized controlled trials related to cutaneous lichen planus. Two systematic reviews and nine relevant randomized controlled trials were identified. Acitretin, griseofulvin, hydroxychloroquine and narrow band ultraviolet B are demonstrated to be effective in the treatment of cutaneous lichen planus. Sulfasalazine is effective, but has an unfavorable safety profile. KH1060, a vitamin D analogue, is not beneficial in the management of cutaneous lichen planus. Evidence from large scale randomized trials demonstrating the safety and efficacy for many other treatment modalities used to treat cutaneous lichen planus is simply not available.

  3. Alain Chouet (entretiens avec Jean Guisnel), Au cœur des services spéciaux. La menace islamiste : fausses pistes et vrais dangers

    OpenAIRE

    Ollivier, Bruno

    2014-01-01

    Quel rapport entre les sciences de l’information et de la communication (sic) et le travail des services spéciaux français regroupés dans la Direction générale de la sécurité extérieure (dgse), vulgairement et bien rapidement appelés services de renseignement ? La question est bien moins anodine qu’il n’y paraît à lire l’ouvrage d’entretiens dans lequel Alain Chouet offre des clés pour comprendre – pour ne prendre que des exemples récents –, au niveau international, la guerre en Syrie, la sit...

  4. Global polarization measurement in Au+Au collisions

    Energy Technology Data Exchange (ETDEWEB)

    Abelev, B.I.; Adams, J.; Aggarwal, M.M.; Ahammed, Z.; Amonett,J.; Anderson, B.D.; Anderson, M.; Arkhipkin, D.; Averichev, G.S.; Bai,Y.; Balewski, J.; Barannikova, O.; Barnby, L.S.; Baudot, J.; Bekele, S.; Belaga, V.V.; Bellingeri-Laurikainen, A.; Bellwied, R.; Benedosso, F.; Bhardwaj, S.; Bhasin, A.; Bhati, A.K.; Bichsel, H.; Bielcik, J.; Bielcikova, J.; Bland, L.C.; Blyth, S.-L.; Bonner, B.E.; Botje, M.; Bouchet, J.; Brandin, A.V.; Bravar, A.; Bystersky, M.; Cadman, R.V.; Cai,X.Z.; Caines, H.; Calderon de la Barca Sanchez, M.; Castillo, J.; Catu,O.; Cebra, D.; Chajecki, Z.; Chaloupka, P.; Chattopadhyay, S.; Chen,H.F.; Chen, J.H.; Cheng, J.; Cherney, M.; Chikanian, A.; Christie, W.; Coffin, J.P.; Cormier, T.M.; Cosentino, M.R.; Cramer, J.G.; Crawford,H.J.; Das, D.; Das, S.; Daugherity, M.; de Moura, M.M.; Dedovich, T.G.; DePhillips, M.; Derevschikov, A.A.; Didenko, L.; Dietel, T.; Djawotho,P.; Dogra, S.M.; Dong, W.J.; Dong, X.; Draper, J.E.; Du, F.; Dunin, V.B.; Dunlop, J.C.; Dutta Mazumdar, M.R.; Eckardt, V.; Edwards, W.R.; Efimov,L.G.; Emelianov, V.; Engelage, J.; Eppley, G.; Erazmus, B.; Estienne, M.; Fachini, P.; Fatemi, R.; Fedorisin, J.; Filimonov, K.; Filip, P.; Finch,E.; Fine, V.; Fisyak, Y.; Fu, J.; Gagliardi, C.A.; Gaillard, L.; Ganti,M.S.; Ghazikhanian, V.; Ghosh, P.; Gonzalez, J.S.; Gorbunov, Y.G.; Gos,H.; Grebenyuk, O.; Grosnick, D.; Guertin, S.M.; Guimaraes, K.S.F.F.; Guo,Y.; Gupta, N.; Gutierrez, T.D.; Haag, B.; Hallman, T.J.; Hamed, A.; Harris, J.W.; He, W.; Heinz, M.; Henry, T.W.; Hepplemann, S.; Hippolyte,B.; Hirsch, A.; Hjort, E.; Hoffman, A.M.; Hoffmann, G.W.; Horner, M.J.; Huang, H.Z.; Huang, S.L.; Hughes, E.W.; Humanic, T.J.; Igo, G.; Jacobs,P.; Jacobs, W.W.; Jakl, P.; Jia, F.; Jiang, H.; Jones, P.G.; Judd, E.G.; Kabana, S.; Kang, K.; Kapitan, J.; Kaplan, M.; Keane, D.; Kechechyan, A.; Khodyrev,V.Yu.; Kim, B.C.; Kiryluk, J.; Kisiel, A.; Kislov, E.M.; Klein,S.R.; Kocoloski, A.; Koetke, D.D.; et al.

    2007-08-02

    The system created in non-central relativisticnucleus-nucleus collisions possesses large orbital angular momentum. Dueto spin-orbit coupling, particles produced in such a system could becomeglobally polarized along the direction of the system angular momentum. Wepresent the results of Lambda and anti-Lambda hyperon global polarizationmeasurements in Au+Au collisions at sqrt sNN=62.4 GeV and 200 GeVperformed with the STAR detector at RHIC. The observed globalpolarization of Lambda and anti-Lambda hyperons in the STAR acceptance isconsistent with zero within the precision of the measurements. Theobtained upper limit, lbar P Lambda, anti-Lambda rbar<= 0.02, iscompared to the theoretical values discussed recently in theliterature.

  5. L'APPRENTISSAGE AU CERN pour la profession d'assistant(e) en information documentaire - French version only

    CERN Document Server

    Susanne Schaefer

    2006-01-01

    APPRENTISSAGE AID FORMATION ET DEVELOPPEMENT DSU/SI L'apprentissage au CERN est régi par les lois, règlements et contrats en vigueur dans le Canton de Genève. En cas de réussite à l'examen de fin d'apprentissage, les apprentis obtiennent le Certificat Fédéral de Capacité Suisse (CFC). 2 places sont offertes pour la formation d'assistant(e) en information documentaire L'apprentissage dure 3 ans. Minima requis pour faire acte de candidature : avoir terminé la scolarité obligatoire être ressortissant d'un pays membre du CERN (Allemagne, Autriche, Belgique, Bulgarie, Danemark, Espagne, Finlande, France, Grèce, Hongrie, Italie, Norvège, Pays-Bas, Pologne, Portugal, République slovaque, République tchèque, Royaume-Uni, Suède, Suisse) pour les assistants en information documentaire : avoir au moins 15 ans et moins de 26 ans à la date de début de l'apprentissage avoir un niveau scolaire correspondant à la 9e à Genève et à la 3e en France (connaissances d'allemand et d'anglais exigées)...

  6. L'APPRENTISSAGE AU CERN pour la profession d'assistant(e) en information documentaire - French version only

    CERN Document Server

    2007-01-01

    APPRENTISSAGE AID DSU/SI - Bibliothèque du CERN L'apprentissage au CERN est régi par les lois, règlements et contrats en vigueur dans le canton de Genève. En cas de réussite à l'examen de fin d'apprentissage, les apprentis obtiennent le Certificat fédéral de capacité suisse (CFC). 2 places sont offertes pour la formation d'assistant(e) en information documentaire. L'apprentissage dure 3 ans. Minima requis pour faire acte de candidature: avoir au moins 15 ans et moins de 26 ans à la date de début de l'apprentissage, avoir terminé la scolarité obligatoire, avoir un niveau scolaire correspondant à la 9e à Genève et à la 3e en France (connaissances d'allemand et d'anglais exigées), être ressortissant d'un pays membre du CERN (Allemagne, Autriche, Belgique, Bulgarie, Danemark, Espagne, Finlande, France, Grèce, Hongrie, Italie, Norvège, Pays-Bas, Pologne, Portugal, République slovaque, République tchèque, Royaume-Uni, Suède, Suisse), pour les résidents en Suisse: être ressortis...

  7. Molecular Bases of Cutaneous and Uveal Melanomas

    Directory of Open Access Journals (Sweden)

    Sudeep Gaudi

    2011-01-01

    Full Text Available Intensive research in recent years has begun to unlock the mysteries surrounding the molecular pathogenesis of melanoma, the deadliest of skin cancers. The high-penetrance, low-frequency susceptibility gene CDKN2A produces tumor suppressor proteins that function in concert with p53 and retinoblastoma protein to thwart melanomagenesis. Aberrant CDKN2A gene products have been implicated in a great many cases of familial cutaneous melanoma. Sporadic cases, on the other hand, often involve constitutive signal transduction along the mitogen-activated protein kinase (MAPK pathway, with particular focus falling upon mutated RAS and RAF protooncogenes. The proliferative effects of the MAPK pathway may be complemented by the antiapoptotic signals of the PI3K/AKT pathway. After skin, melanoma most commonly affects the eye. Data for the constitutive activation of the MAPK pathway in uveal melanoma exists as well, however, not through mutations of RAS and RAF. Rather, evidence implicates the proto-oncogene GNAQ. In the following discussion, we review the major molecular pathways implicated in both familial and sporadic cutaneous melanomagenesis, the former accounting for approximately 10% of cases. Additionally, we discuss the molecular pathways for which preliminary evidence suggests a role in uveal melanomagenesis.

  8. Cutaneous Leishmaniasis – Dermoscopic Findings And Cryotherapy

    Directory of Open Access Journals (Sweden)

    Dobrev Hristo P.

    2015-03-01

    Full Text Available We present a 60-year-old male patient who, three months after a holiday in Southern Greece, found a small ‘pimple’ on his back, which gradually got as big as a small walnut, the central part becoming ulcerated and scabby. Dermatological examination found an erythematous-to-livid nodular lesion on the right shoulder; it was 16 mm in diameter with central ulceration, covered with brownish crust which discharged pus-like secretion upon pressure. Microscope examination of Romanowsky-Giemsa stained lesion material detected amastigote forms of Leishmania tropica. The culture investigation and serological tests for leishmaniasis were negative. Dermoscopy of the lesion found the following features: erythema, hyperkeratosis, central ulceration covered with brownish crust, “yellow tears-like” structures and “white starburst-like” patterns, and various vascular structures (including dotted vessels, comma-shaped vessels, hairpin- and glomerular-like vessels. The patient was diagnosed with cutaneous leishmaniasis and underwent four cryotherapy sessions every other week with excellent therapeutic results - complete resolution of infiltrate with subsequent gentle hypopigmented scarring. In conclusion, dermoscopy is an easily accessible non-invasive method which can be useful for the diagnosis of cutaneous leishmaniasis. Cryotherapy is the treatment of choice for single skin lesions.

  9. Primary cutaneous melanoma: an 18-year study

    Directory of Open Access Journals (Sweden)

    Moris Anger

    2010-01-01

    Full Text Available BACKGROUND: Primary cutaneous melanoma still constitutes the main cause of skin cancer death in developed countries, and its incidence in recent years has been increasing in a steady, worrisome manner. OBJECTIVES: This study evaluated the clinical, epidemiological and demographic aspects of this disease, and correlated them with patient prognosis. METHODS: Using epidemiologic and clinical data, we analyzed 84 patients with mild to severe primary cutaneous melanoma treated between 1990 and 2007. Slides containing surgical specimens were analyzed, and new slides were made from archived paraffin sections when necessary. RESULTS: The melanoma incidence was higher in areas of sun exposure, with lesions commonly observed in the trunk for males, and lower limbs for females. In addition to Breslow's thickness and ulceration (p = 0.043 and p 1 mm and 4 mm and the mitotic index (0 when absent or 1 when >1 per mm² allowed the establishment of a prognostic score: if the sum was equal to or over three, nearly all (91.7% patients had systemic disease. The 5-year survival was approximately seventy percent. CONCLUSION: Because American Join Committee of Cancer Staging will update the classification of malignant tumors (TNM staging in the near future, and introduce mitosis as a prognostic factor, our results show the importance of such a feature. Additional studies are necessary to confirm the importance of a prognostic score as proposed herein.

  10. Reconstructive dosimetry for cutaneous radiation syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Lima, C.M.A.; Lima, A.R.; Degenhardt, Ä.L.; Da Silva, F.C.A., E-mail: dasilva@ird.gov.br [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Valverde, N.J. [Fundacao Eletronuclear de Assistencia Medica, Rio de Janeiro, RJ (Brazil)

    2015-10-15

    According to the International Atomic Energy Agency (IAEA), a relatively significant number of radiological accidents have occurred in recent years mainly because of the practices referred to as potentially high-risk activities, such as radiotherapy, large irradiators and industrial radiography, especially in gammagraphy assays. In some instances, severe injuries have occurred in exposed persons due to high radiation doses. In industrial radiography, 80 cases involving a total of 120 radiation workers, 110 members of the public including 12 deaths have been recorded up to 2014. Radiological accidents in industrial practices in Brazil have mainly resulted in development of cutaneous radiation syndrome (CRS) in hands and fingers. Brazilian data include 5 serious cases related to industrial gammagraphy, affecting 7 radiation workers and 19 members of the public; however, none of them were fatal. Some methods of reconstructive dosimetry have been used to estimate the radiation dose to assist in prescribing medical treatment. The type and development of cutaneous manifestations in the exposed areas of a person is the first achievable gross dose estimation. This review article presents the state-of-the-art reconstructive dosimetry methods enabling estimation of local radiation doses and provides guidelines for medical handling of the exposed individuals. The review also presents the Chilean and Brazilian radiological accident cases to highlight the importance of reconstructive dosimetry. (author)

  11. [Treatment of cutaneous leishmaniasis--an update].

    Science.gov (United States)

    Vardy, Daniel A; Gilead, Leon; Frankenburg, Shoshana

    2002-01-01

    Cutaneous leishmaniasis (CL) is a skin disease that manifests as ulcerated nodules, up to several centimeters in size, that persist for many months in spite of various therapies. The disease is a dermal infection with eukaryotic protozoa of the genus Leishmania, transferred by the bite of a female sand-fly, and therefore usually present on exposed areas of the skin such as limbs and face. The disease is endemic in specific geographical areas of Israel, mainly in the Jordan and Jericho valley, part of the Dead-Sea area, Kfar Edomim area, and parts of the Negev such as Ketziot and the Arava. Cutaneous leishmaniasis (CL) presents a significant health hazard in Israel, mainly to non-residents, such as soldiers or new immigrants, travelling to endemic areas. It is also not unusual to find patients with CL acquired during adventure travelling to South America. Treatment modalities available for treating CL are limited and often unpleasant. Over the past few years several new therapies for visceral leishmaniasis have become available raising hope for the development of more effective treatment options for CL. In this review we discuss the disease and its therapeutic options and also report a novel treatment for CL using ethanolic amphotericin B.

  12. Cutaneous Complications of Targeted Melanoma Therapy.

    Science.gov (United States)

    de Golian, Emily; Kwong, Bernice Y; Swetter, Susan M; Pugliese, Silvina B

    2016-11-01

    The landscape of advanced and metastatic melanoma therapy has shifted dramatically in recent years. Since 2011, eight drugs (ipilimumab, vemurafenib, dabrafenib, trametinib, cometinib, pembrolizumab, nivolumab, and talimogene laherparepvec) have received FDA approval for the treatment of advanced or metastatic melanoma, including combination regimens of both small molecule kinase and immune checkpoint inhibitors. These therapies have revolutionized the management of unresectable regional nodal and distant melanoma, providing hope of extended survival to patients. As the use of novel agents has increased, so have the cutaneous toxicities associated with these medications. While most skin reactions are low-grade and can be managed conservatively with topical therapies, malignant lesions and more serious or life-threatening drug reactions can arise during therapy, requiring prompt dermatologic recognition and treatment in order to improve patient outcome. Given the survival benefit attributed to these new agents, treating skin toxicity and maintaining patient quality of life is of paramount importance. Oncologists should be aware of the common cutaneous toxicities associated with these medications and should be encouraged to involve dermatologists in the collaborative care of advanced melanoma patients. Close communication between oncologists and dermatologists can help to avoid unnecessary dose reduction or treatment discontinuation and identify situations when treatment cessation is truly warranted.

  13. Disseminated cutaneous histoplasmosis in an immunocompetent adult

    Directory of Open Access Journals (Sweden)

    Manoj Harnalikar

    2012-01-01

    Full Text Available Histoplasmosis, a systemic mycosis caused by the dimorphic fungus Histoplasma capsulatum var capsulatum and Histoplasma capsulatum var duboisii is endemic to many parts of the world. The clinical manifestations range from acute or chronic pulmonary infection to a progressive disseminated disease. After initial exposure to the fungus, the infection is self-limited and restricted to the lungs in 99% of healthy individuals. The remaining 1%, however, progress to either disseminated or chronic disease involving the lungs, liver, spleen, lymph nodes, bone marrow or rarely, the skin and mucous membranes. Mucocutaneous histoplasmosis is frequently reported in patients with acquired immune deficiency syndrome (AIDS, but it is rare in immunocompetent hosts. A 60-year-old male presented with asymptomatic swelling of the hard palate and crusted papules and nodules over the extremities, face and trunk. Clinically, the diagnoses of cutaneous cryptococcosis versus histoplasmosis was considered in this patient. A chest X-ray revealed hilar lymphadenopathy. Enzyme-linked immunosorbent assay (ELISA for human immunodeficiency virus (HIV was nonreactive. Skin biopsy revealed multiple tiny intracellular round yeast forms with a halo in the mid-dermis. Culture of the skin biopsy in Sabouraud′s dextrose agar showed colonies of Histoplasma capsulatum. Despite an investigation including no evidence of underlying immunosuppression was found, he was started on IV amphotericin-B (0.5 mg/kg/day. However, the patient succumbed to his disease 2 days after presentation. We report a rare case of disseminated cutaneous histoplasmosis in an immunocompetent individual.

  14. [Extensive cutaneous candidiasis revealing cutaneous T-cell lymphoma: 2 cases].

    Science.gov (United States)

    Duong, T; Ingen-Housz-Oro, S; Gaulier, A; Petit, A; Dubertret, L; Sigal-Grinberg, M

    2006-01-01

    During the course of immunodeficiency diseases, severe candidiasis can occur with extensive cutaneous and mucous membrane lesions. However, blood dyscrasias are very rarely revealed by diffuse candidiasis. We report two case of cutaneous T-cell lymphoma revealed by extensive and atypical cutaneous candidiasis. Case No. 1:A 72-year-old woman presented a pruritic rash of circinate, serpiginous patches on glabrous skin and skinfolds with multiple intertrigo and rapidly worsening palmoplantar keratoderma. All mycological skin specimens tested positive for Candida albicans. Histological examination of a biopsy sample from a serpiginous patch revealed the presence of fungal elements while palmoplantar keratoderma biopsy showed an epidermotropic lymphocytic infiltrate in the superficial dermis evocative of mycosis fungoides. Blood tests showed a white cell count of 28 600/mm3 with 14% circulating Sezary cells and a T-cell clone. The T-cell lymphoma was treated with methotrexate, but the disease worsened a few months later, progressing to CD30- large T-cell pleomorphic lymphoma. The patient died of severe sepsis. Case No 2:A 60-year-old man presented a macular rash over the face, trunk and skinfolds as well as erythematous scaly annular plaques of the glabrous skin with lymphadenopathy. Cultures of skin scrapings were all positive for Candida albicans. Blood tests showed a white cell count of 15 000/mm3 with 30% circulating Sezary cells. A trunk patch biopsy revealed the histological appearance of mycosis fungoides. There was a T-cell clone in the peripheral blood and skin. In both cases, the patients presented with widespread annular and erythematous scaly lesions of the glabrous skin and skinfolds with evidence of Candida albicans on fungal tests of all skin scrapings. The discovery of circulating Sezary cells on a systematic smear for hyperleukocytosis led us to suspect underlying cutaneous T-cell lymphoma, which was confirmed by biopsy of the skin lesions accompanying

  15. d + Au hadron correlation measurements at PHENIX

    Energy Technology Data Exchange (ETDEWEB)

    Sickles, Anne M., E-mail: anne@bnl.gov

    2014-06-15

    In these proceedings, we discuss recent results from d + Au collisions in PHENIX ridge related measurements and their possible hydrodynamic origin. We present the v{sub 2} at midrapidity and measurements of the pseudorapidity dependence of the ridge, distinguishing between the d-going and Au-going directions. We investigate the possible geometrical origin by comparing v{sub 2} in d + Au to that in p + Pb, Au + Au and Pb + Pb collisions. Future plans to clarify the role of geometry in small collision systems at RHIC are discussed.

  16. Genre et accés au foncier au Sénégal

    International Development Research Centre (IDRC) Digital Library (Canada)

    niveau des pays concernés. (Bénin, Kenya, Malawi,. Rwanda, Sénégal, Tunisie) en mobilisant les SIG-P comme outils méthodologiques de participation et d'aide à la prise de décisions. ict4d ... nombre d'individus à cause de la crise des revenus agricoles. ... densité démographique, ou les enjeux fonciers semblent moins ...

  17. Decay spectroscopy of $^{178}$Au

    CERN Document Server

    Whitmore, B

    In this thesis, the neutron-deficient nucleus $^{178}$Au is investigated through decay spectroscopy. Si and HPGe detectors were used to analyse the decay radiation of $^{178}$Au and its daughter nuclei. Previous studies have been unable to distinguish decay radiation from different isomeric states of this nucleus. This thesis represents the first time such isomeric discrimination has been achieved, and presents tentative spin assignments of both the ground state and an isomer. The neutron-deficient gold isotopes are an area of interest for the study of shape coexistence. This is the phenomenon exhibited by nuclei able to exist at a number of close lying energy minima, each reflecting a distinct type of deformation. It is hoped that studies such as this can help identify the evolution of nuclear deformation in this region of the nuclear chart.

  18. Multifocal childhood cutaneous tuberculosis: report of two interesting cases from Sikkim, India.

    Science.gov (United States)

    Verma, Shikha; Thakur, Binod Kumar; Gupta, Amlan

    2013-01-01

    Cutaneous tuberculosis is an important health problem in developing countries such as India. Poverty, overcrowding, malnutrition, and ignorance are predisposing factors. The commonly seen variants of cutaneous tuberculosis are scrofuloderma, lupus vulgaris, and tuberculosis verrucosa cutis. Malnourished children may present with unusual forms of cutaneous tuberculosis. Herein we report two interesting cases of multifocal cutaneous tuberculosis in malnourished children. © 2012 Wiley Periodicals, Inc.

  19. Le CRDI au Costa Rica

    International Development Research Centre (IDRC) Digital Library (Canada)

    La stabilité politique du Costa Rica a fait de ce pays un partenaire essen- tiel du CRDI en Amérique centrale pour la recherche portant sur l'agriculture, les politiques économiques, la démocratisation et la prévention des catastrophes naturelles. Le CRDI a beaucoup contribué à la recherche en agriculture au Costa Rica,.

  20. Cas de Cotonou au Benin

    African Journals Online (AJOL)

    Au nombre de ces nuisances, figurent entre autres, la perte de temps et par ricochet d'importantes recettes .... La méthodologie utilisée est basée sur deux types d'approches : l'approche théorique et celle empirique. Le premier volet de ...... Université de Bordeaux Talence, 456 pages. SEGBEDJI, E. (2001) : Impact du trafic ...

  1. L’apprentissage au CERN

    CERN Multimedia

    Staff Association

    2016-01-01

    En 1961, sur la base du constat que l’évolution du marché du travail nécessitait un besoin croissant de personnel qualifié, le 1er accord entre la République et canton de Genève et le CERN fut signé. Cet accord avait notamment pour objet la formation professionnelle de jeunes électroniciens et techniciens de laboratoires en physique. Le CERN, acteur local économique d’importance, soulignait par cet accord sa volonté de participer au développement économique et social local. Le 1er apprenti arriva au CERN en 1965. En 1971, le centre d’apprentissage fut créé ; il accueille aujourd’hui plus d’une vingtaine d’apprentis au total, à raison d’environ six nouveaux apprentis chaque année. Cet apprentissage est dédié aux jeunes âgés e...

  2. Prevalence of Cutaneous Leishmaniasis in Ramshir, Iran; an Epidemiological Study

    Directory of Open Access Journals (Sweden)

    Vazirianzadeh B.* PhD,

    2014-08-01

    Full Text Available Aims Cutaneous leishmaniasis is a prevalent parasitological disease with diverse clinical manifestations in Iran. Therefore, the present retrospective study carried out to describe the demographic features of cutaneous leishmaniasis in Ramshir, Iran. Materials & Methods This descriptive study was performed on 136 cutaneous leishmaniasis patients whose data were recorded in the Ramshir health center during 2006-9. Demographic information of patients including age, sex, habitat and sites of lesions, month and years of incidence were recorded. The data were analyzed by SPSS 16 software. Findings Totally 79 patients (58.1% resided in urban areas and the born to 9 years (49.3% was recognized as the most infected age group. Hands (41.2% had the highest rates of cutaneous leishmaniasis lesions followed by face (36.0% and foot (22.8%. The maximum number of cutaneous leishmaniasis lesions was reported in March. Conclusion As cutaneous leishmaniasis in Ramshir seemed to be an endemic rural type, the appropriate preventing measures regarding to the rural cutaneous leishmaniasis should be considered to decrease incidence of the disease in the region.

  3. Unusual cutaneous manifestations of B-cell chronic lymphocytic leukemia.

    Science.gov (United States)

    Plaza, Jose Antonio; Comfere, Nneka I; Gibson, Lawrence E; Colgan, Michael; Davis, Dawn Marie R; Pittelkow, Mark R; Colgan, Joseph P

    2009-05-01

    B-cell chronic lymphocytic leukemia (B-CLL) is a low-grade lymphoproliferative disorder with characteristic histomorphologic features and an identifiable immunophenotype. The skin can be involved in the context of known disease, but cutaneous signs are rarely the presenting findings. Evaluation of unusual clinical cutaneous presentations of B-CLL. We conducted a retrospective case series analysis of 3 patients with unusual cutaneous clinicopathologic presentations of B-cell chronic lymphocytic leukemia, including erythematous plaques, angiomatosis/telangiectasia, and erosive skin changes, respectively, without a previous clinical history of chronic lymphocytic lymphoma. Main outcome measures were clinical cutaneous presentations and histopathologic results in the diagnosis of underlying disease. In the 3 cases, lesion locations were the lower cheek, lower extremity, and penis (groin region). Histomorphologic testing showed mild to dense perivascular and periadnexal lymphoid aggregates throughout the dermis and extending into the panniculus, consistent with B-CLL. The diagnosis was confirmed with immunohistochemical studies that showed coexpression of CD5 and CD20 in the neoplastic lymphocytic infiltrate. None. Cutaneous manifestations are an uncommon presentation of subclinical B-CLL. Cutaneous changes were the presenting features of underlying lymphoma in all 3 cases, highlighting the importance of maintaining a high index of suspicion for a lymphoproliferative process in cases with unusual or atypical clinicopathologic features. Additional investigations into the behavior of B-CLL in the skin may elucidate further the evolution of cutaneous lesions in this disease.

  4. Cutaneous Findings Mistaken for Physical Abuse: Present but Not Pervasive.

    Science.gov (United States)

    Schwartz, Kimberly A; Metz, James; Feldman, Kenneth; Sidbury, Robert; Lindberg, Daniel M

    2014-02-26

    Incorrect diagnoses during child abuse evaluations are serious. Because skin lesions are common in abuse, it is important to consider cutaneous mimics of physical abuse. The current study prospectively identified cutaneous mimics in a cohort of children evaluated for possible physical abuse. This is a secondary analysis of data from the Examining Siblings To Recognize Abuse research network's prospective, observational, cross-sectional study involving 20 U.S. child abuse teams. Subjects were younger than 10 years old and were evaluated by child abuse physicians (CAPs) for concerns of physical abuse. CAPs prospectively documented whether mimics were identified during their physical abuse evaluations. Details of each patient with cutaneous mimics were evaluated to determine the types of mimics, which part of the evaluations identified mimics, and the perceived abuse likelihood. Of 2,890 children evaluated for physical abuse, 137 had at least one mimic identified and 69 had some cutaneous mimic components. Although 985 of 2,753 (39%) subjects without mimics had high levels of abuse concern, only 9 of 137 (6%) children with mimics had high levels of abuse concern (p physical examination. Cutaneous abuse mimics were identified in 2.4% of children evaluated for physical abuse. Although it was eventually determined that there was little or no concern for abuse in 84% of children with cutaneous mimics, a small number were physically abused. CAP evaluation may be valuable in recognizing children with cutaneous mimics who also were abused. © 2014 Wiley Periodicals, Inc.

  5. Cutaneous Horn-Related Kaposi's Sarcoma: A Case Report

    Science.gov (United States)

    Onak Kandemir, Nilufer; Gun, Banu Dogan; Barut, Figen; Solak Tekin, Nilgun; Ozdamar, Sukru Oguz

    2010-01-01

    Cutaneous horn is characterized by the accumulation of abnormal keratinized material and may occur in association with a variety of benign, premalignant, and malignant cutaneous lesions. Cutaneous horn occurs very rarely in association with soft-tissue neoplasias. A cutaneous horn located on the toe was completely removed by excision in a 78-year-old male patient. Macroscopic examination revealed a hemorrhagic nodular lesion, 0.5 cm in diameter, located on the dermis underlying the cutaneous horn with a height of 1 cm. Histopathological examination revealed a neoplastic lesion consisting of fusiform cells and extravasated erythrocytes underlying the compact keratin mass. The immunohistochemical analysis showed immunoexpression of endothelial markers and HHV8 in fusiform cells. The case was evaluated as “cutaneous horn developed in a nodular stage Kaposi's sarcoma.” Our case is the second case of cutaneous horn related to Kaposi's sarcoma reported in the English literature and is presented in this case report with its clinical and histopathological features. PMID:20862349

  6. Cutaneous Horn-Related Kaposi's Sarcoma: A Case Report

    Directory of Open Access Journals (Sweden)

    Nilufer Onak Kandemir

    2010-01-01

    Full Text Available Cutaneous horn is characterized by the accumulation of abnormal keratinized material and may occur in association with a variety of benign, premalignant, and malignant cutaneous lesions. Cutaneous horn occurs very rarely in association with soft-tissue neoplasias. A cutaneous horn located on the toe was completely removed by excision in a 78-year-old male patient. Macroscopic examination revealed a hemorrhagic nodular lesion, 0.5 cm in diameter, located on the dermis underlying the cutaneous horn with a height of 1 cm. Histopathological examination revealed a neoplastic lesion consisting of fusiform cells and extravasated erythrocytes underlying the compact keratin mass. The immunohistochemical analysis showed immunoexpression of endothelial markers and HHV8 in fusiform cells. The case was evaluated as “cutaneous horn developed in a nodular stage Kaposi's sarcoma.” Our case is the second case of cutaneous horn related to Kaposi's sarcoma reported in the English literature and is presented in this case report with its clinical and histopathological features.

  7. Fabricating a Homogeneously Alloyed AuAg Shell on Au Nanorods to Achieve Strong, Stable, and Tunable Surface Plasmon Resonances

    KAUST Repository

    Huang, Jianfeng

    2015-08-13

    Colloidal metal nanocrystals with strong, stable, and tunable localized surface plasmon resonances (SPRs) can be useful in a corrosive environment for many applications including field-enhanced spectroscopies, plasmon-mediated catalysis, etc. Here, a new synthetic strategy is reported that enables the epitaxial growth of a homogeneously alloyed AuAg shell on Au nanorod seeds, circumventing the phase segregation of Au and Ag encountered in conventional synthesis. The resulting core–shell structured bimetallic nanorods (AuNR@AuAg) have well-mixed Au and Ag atoms in their shell without discernible domains. This degree of mixing allows AuNR@AuAg to combine the high stability of Au with the superior plasmonic activity of Ag, thus outperforming seemingly similar nanostructures with monometallic shells (e.g., Ag-coated Au NRs (AuNR@Ag) and Au-coated Au NRs (AuNR@Au)). AuNR@AuAg is comparable to AuNR@Ag in plasmonic activity, but that it is markedly more stable toward oxidative treatment. Specifically, AuNR@AuAg and AuNR@Ag exhibit similarly strong signals in surface-enhanced Raman spectroscopy that are some 30-fold higher than that of AuNR@Au. When incubated with a H2O2 solution (0.5 m), the plasmonic activity of AuNR@Ag immediately and severely decayed, whereas AuNR@AuAg retained its activity intact. Moreover, the longitudinal SPR frequency of AuNR@AuAg can be tuned throughout the red wavelengths (≈620–690 nm) by controlling the thickness of the AuAg alloy shell. The synthetic strategy is versatile to fabricate AuAg alloyed shells on different shaped Au, with prospects for new possibilities in the synthesis and application of plasmonic nanocrystals.

  8. Les contributions de la psychologie cognitive a l'enseignement strategique des langues secondes au niveau universitaire (The Contributions of Cognitive Psychology to Strategic Second Language Instruction at the University Level).

    Science.gov (United States)

    Besnard, Christine

    1995-01-01

    Contributions of the field of cognitive psychology to second language instruction are reviewed. It is proposed that these concepts can contribute not only to classroom language instruction, but also to methodology of language teacher education. (MSE)

  9. Understanding and Modeling Vortical Flows to Improve the Technology Readiness Level for Military Aircraft (Comprehension et Modelisation des Flux de Vortex Pour Ameliorer le Niveau de Maturite Technologique au Profit des Avions Militaires)

    Science.gov (United States)

    2009-10-01

    on Cplim or KT 33-15 33.3.2.2 Aerofoil Geometry Effects on Cplim and KT 33-19 33.3.3 LE Thrust Considerations for Swept 3-D Wings 33-21 33.3.3.1...Cp Distributions and Local Force Coefficients ct and cn 33-13 Figure 33-14 Family of Aerofoil Sections, Differing t/c, Maximum Thickness tmax at... Aerofoil Parameters and Normal 33-20 Mach Number (see also Figure 33-23) Figure 33-23 Sweep Theory and Definition of Normal Aerofoil Sections from

  10. CARBO-CONTROLE. Quantification of the carbon flux and stocks at the european and national scale; CARBO-CONTROLE. Quantification des flux et stocks de carbone au niveau Europeen et national

    Energy Technology Data Exchange (ETDEWEB)

    Ciais, P

    2007-07-01

    The CARBO-CONTROLE project aims to evaluate the different methodologies to estimate the CO{sub 2} flux at the european, national and regional scale. The strategy is to combine a crumbling, down scaling, of the flux at a big scale, by inverting the atmospheric CO{sub 2} measures with a aggregation, up scaling, of the national stocks and flux from the climatic parameters of a model of ecosystems.They show that with the monthly data of the global network of CO{sub 2} monitoring stations, it is possible to obtain an estimation of the european flux. Meanwhile the errors bond to the leak of continental stations are of the order of the flux average. (A.L.B.)

  11. Contribution à l’étude d’un Syndrome nerveux chez les ovins au niveau de la Commune d’Ait Ichou, Oulmès: Enquêtes Epidémiologiques

    Directory of Open Access Journals (Sweden)

    F. Ezzahra LAHKAK

    2014-10-01

    Full Text Available The present work is a contribution to the investigation of a neurological syndrome of unknown etiology (locally called Taghara which means seizures that affects sheep in the Ait Ichou area.The study was first approached by interviewing farmers to collect epidemiological data.The results showed that (1 Disease prevalence was on average 4.76 %, with 67 % of flocks having a prevalence less than 10 % and only 6 % had prevalence between 40 and 66 %, (2 About 50 % of interviewed farmers ignored the disease cause and about 10 % attributed this disorder to plants intoxication or cold, (3 The disease appeared mainly during the cold season (72 % of cases, (4 Seizures are in 68% of cases triggered by external stimulus of the diseased animals, (5 More than 50 % of affected animals died following fall in ravines whereas the spontaneous recovery was observed only in 12 % of cases, (6 Sheep flocks spent most time on forest and are rarely supplemented and when a complementation was given, it is usually performed during mating (40 % and lambing (30 % seasons compared to 10 % during the period of disease occurrence, (7 The disease has no interference with reproduction, affects exclusively adult animals (>1 year and both sexes, (8 The veterinarians in the area imputed the disease in part to plant poisoning but no specific treatment has yet been developed.

  12. LA LIBÉRALISATION DES MARCHÉS DE L´ÉLECTRICITÉ ET DU GAZ NATUREL AU NIVEAU EUROPÉEN – ENJEUX ET DÉFIS ACTUELS

    Directory of Open Access Journals (Sweden)

    Irina Maria Găman

    2010-06-01

    Full Text Available The creation of an internal energy market at the European level becomes nowadays a sine qua non condition for a single and coherent voice on energy issues at the global level for the EU. One essential step to be done is the liberalization of energy sectors, such as electricity and natural gas. This process of liberalization for the electricity and gas market should have been totally and homogeneously accomplished by the mid of 2007 by the member states of the EU, goal established by the European Commission through two legal instruments, more precisely the Directive 2003/54/EC and the Directive 2003/55/EC. Despite the European legislative settlement and despite the existence of common institutions of regularization, the liberalization has its limits. How these limits can be explained and which are the factors for the heterogeneous degree of liberalization of the electricity and gas markets at the European level? This article is focusing on the specific economic and political factors through which the limits of liberalization of energy markets can be explained.

  13. Performance d’Hemocue Hb 201+ dans le diagnostic de l’anémie de l’enfant dans les structures sanitaires du niveau périphérique au Togo

    Directory of Open Access Journals (Sweden)

    Ahoefa Vovor

    2013-12-01

    Full Text Available Contexte: L’anémie est un problème de santé publique dans le monde entier, et notamment dans les pays en développement. Elle a des répercussions majeures sur la santé et sur ledéveloppement économique et social d’un pays. La prise en charge des patients anémiés étant nécessaire, il faut un diagnostic biologique précis, et donc un dosage du taux d’hémoglobine par des méthodes fiables. Objectif: Évaluer les performances diagnostiques du test Hemocue Hb201+®. Méthodes: Étude comparative de la mesure du taux d’hémoglobine à partir du photomètre Hemocue Hb 201+® et d’analyseurs d’hématologie chez 213 enfants de 6 à 59 mois souffrant d’un paludisme simple; la détermination du taux d’hémoglobine par les analyseurs est retenue comme méthode de référence pour évaluer Hemocue Hb201+®. Résultats: 72.8% des valeurs obtenues par Hemocue Hb201+® étaient à ±1 g/dl de celles de la méthode de référence. Le coefficient de corrélation de Pearson était de 0.80. La prévalence de l’anémie était de 79.3% pour la méthode de référence et de 77.9% pour Hemocue Hb201+®. La sensibilité et la spécificité de l’analyseur Hemocue Hb201+® étaient respectivement de 95.1% et de 65.3%. Conclusion: Les résultats de l’étude ont montré que le test Hemocue Hb201+® présentait une bonne sensibilité, une spécificité moyenne et une exactitude moyenne dans le diagnostic del’anémie et dans le dosage de l’hémoglobine. Son utilisation peut être recommandée dans les structures périphériques afin de faciliter le diagnostic biologique de l’anémie et sa prise encharge dans les populations vivant dans les zones difficiles d’accès. Performance of HemoCue Hb201+ in the diagnosis of anaemia in children in health facilitiesat the peripheral level in Togo Background: Anaemia is a global public health problem, especially in developing countries. Anaemia has major repercussions on health status, as well as on the economic and social development of a country. Effective care of anaemic patients requires a reliable and precisediagnostic test that can determine haemoglobin levels. Objective: To evaluate the diagnostic performance of the Hemocue test Hb201+®. Method: This study compared haemoglobin levels measured using the photometer Hemocue Hb201+® with those measured by analysers of haematology. Children aged 6 to 59 months who suffered from uncomplicated malaria were eligible for inclusion. Haemoglobin levels determined by the analysers were considered the reference for evaluation of the levels measured using Hemocue Hb201+®. Results: 72.8% of the values obtained by Hemocue Hb201® were within ±1g/dl of the reference value. The Pearson correlation coefficient was 0.80. The prevalence of anaemia was 79.3% using the reference method and 77.9% using Hemocue 201+®. The sensitivity and the specificity of Hemocue Hb201+® were 95.1% and 65.3% respectively. Conclusion: The study results showed that the Hemocue Hb201 test+® provided good sensitivity, average specificity and average precision, both for the diagnosis of anaemia and for the determination of haemoglobin levels. It may be used in peripheral centres to facilitate the laboratory diagnosis of anaemia and its management in populations that live in areas with difficult accessibility.

  14. Affinité et organisation écologique du peuplement coléoptèrologique des écosystèmes dunaires mobiles au niveau de la frange septentrionale et de la région oriental du Maroc

    OpenAIRE

    Khalid BOURAADA; G. CHAVANON; A. JANATI IDRISSI; M. ESSAFI

    2015-01-01

    The present work aims for a better understanding of the ecological organization of entomological groups of beetles found in mobile dunes of Eastern Morocco and in the northern fringe of the Sahara. This study is carried out over a route of 4000 km from the Guercif dunes (north) to the large dunes of Merzouga (Sahara), passing by dunes of the following stations: Northeast Missour ; Midelt, Aïn Beni Methar, Tendrara, Rich, Boulman, Bouârfa, Boudnib and Erfoud. From analysis of affinity, three m...

  15. Affinité et organisation écologique du peuplement coléoptèrologique des écosystèmes dunaires mobiles au niveau de la frange septentrionale et de la région oriental du Maroc

    Directory of Open Access Journals (Sweden)

    Khalid BOURAADA

    2015-01-01

    Full Text Available The present work aims for a better understanding of the ecological organization of entomological groups of beetles found in mobile dunes of Eastern Morocco and in the northern fringe of the Sahara. This study is carried out over a route of 4000 km from the Guercif dunes (north to the large dunes of Merzouga (Sahara, passing by dunes of the following stations: Northeast Missour ; Midelt, Aïn Beni Methar, Tendrara, Rich, Boulman, Bouârfa, Boudnib and Erfoud. From analysis of affinity, three major faunal groups were identified. The first group is formed by the northern stations (Guercif, Northeast Missour, Midelt and Aïn Beni Methar housing faunal species of the Mediterranean dunes. The second group consists of Tendrara, Bouârfa, Rich and Bouânane stations, having a high level of fauna similarity due in part to their proximity. The last group was formed by the station of Merzouga, Erfoud, Boudnib and Figuig which feature a frankly Saharan population. Taxa collected in these Saharan stations were collected along a north-south geographical gradient whose northern end is formed by the characteristic species of the Mediterranean area while the southern end is made of the wildlife species characteristic of the Saharan fringe.

  16. Performance d’Hemocue Hb 201+ dans le diagnostic de l’anémie de l’enfant dans les structures sanitaires du niveau périphérique au Togo

    Directory of Open Access Journals (Sweden)

    Ahoefa Vovor

    2013-03-01

    Full Text Available Contexte: L’anémie est un problème de santé publique dans le monde entier, et notamment dans les pays en développement. Elle a des répercussions majeures sur la santé et sur ledéveloppement économique et social d’un pays. La prise en charge des patients anémiés étant nécessaire, il faut un diagnostic biologique précis, et donc un dosage du taux d’hémoglobine par des méthodes fiables.Objectif: Évaluer les performances diagnostiques du test Hemocue Hb201+®.Méthodes: Étude comparative de la mesure du taux d’hémoglobine à partir du photomètre Hemocue Hb 201+® et d’analyseurs d’hématologie chez 213 enfants de 6 à 59 mois souffrant d’un paludisme simple; la détermination du taux d’hémoglobine par les analyseurs est retenue comme méthode de référence pour évaluer Hemocue Hb201+®.Résultats: 72.8% des valeurs obtenues par Hemocue Hb201+® étaient à ±1 g/dl de celles de la méthode de référence. Le coefficient de corrélation de Pearson était de 0.80. La prévalence de l’anémie était de 79.3% pour la méthode de référence et de 77.9% pour Hemocue Hb201+®. La sensibilité et la spécificité de l’analyseur Hemocue Hb201+® étaient respectivement de 95.1% et de 65.3%.Conclusion: Les résultats de l’étude ont montré que le test Hemocue Hb201+® présentait une bonne sensibilité, une spécificité moyenne et une exactitude moyenne dans le diagnostic del’anémie et dans le dosage de l’hémoglobine. Son utilisation peut être recommandée dans les structures périphériques afin de faciliter le diagnostic biologique de l’anémie et sa prise encharge dans les populations vivant dans les zones difficiles d’accès.Performance of HemoCue Hb201+ in the diagnosis of anaemia in children in health facilitiesat the peripheral level in TogoBackground: Anaemia is a global public health problem, especially in developing countries. Anaemia has major repercussions on health status, as well as on the economic and social development of a country. Effective care of anaemic patients requires a reliable and precisediagnostic test that can determine haemoglobin levels.Objective: To evaluate the diagnostic performance of the Hemocue test Hb201+®.Method: This study compared haemoglobin levels measured using the photometer Hemocue Hb201+® with those measured by analysers of haematology. Children aged 6 to 59 months who suffered from uncomplicated malaria were eligible for inclusion. Haemoglobin levels determined by the analysers were considered the reference for evaluation of the levels measured using Hemocue Hb201+®.Results: 72.8% of the values obtained by Hemocue Hb201® were within ±1g/dl of the reference value. The Pearson correlation coefficient was 0.80. The prevalence of anaemia was 79.3% using the reference method and 77.9% using Hemocue 201+®. The sensitivity and the specificity of Hemocue Hb201+® were 95.1% and 65.3% respectively.Conclusion: The study results showed that the Hemocue Hb201 test+® provided good sensitivity, average specificity and average precision, both for the diagnosis of anaemia and for the determination of haemoglobin levels. It may be used in peripheral centres to facilitate the laboratory diagnosis of anaemia and its management in populations that live in areas with difficult accessibility.

  17. Topical menthol increases cutaneous blood flow.

    Science.gov (United States)

    Craighead, Daniel H; Alexander, Lacy M

    2016-09-01

    Menthol, the active ingredient in several topically applied analgesics, activates transient receptor potential melastatin 8 (TRPM8) receptors on sensory nerves and on the vasculature inducing a cooling sensation on the skin. Ilex paraguariensis is also a common ingredient in topical analgesics that has potential vasoactive properties and may alter the mechanisms of action of menthol. We sought to characterize the microvascular effects of topical menthol and ilex application and to determine the mechanism(s) through which these compounds may independently and combined alter cutaneous blood flow. We hypothesized that menthol would induce vasoconstriction and that ilex would not alter skin blood flow (SkBF). Three separate protocols were conducted to examine menthol and ilex-mediated changes in SkBF. In protocol 1, placebo, 4% menthol, 0.7% ilex, and combination menthol+ilex gels were applied separately to the skin and red cell flux was continuously measured utilizing laser speckle contrast imaging (LSCI). In protocol 2, seven concentrations of menthol gel (0.04%, 0.4%, 1%, 2%, 4%, 7%, 8%) were applied to the skin to model the dose-response curve. In protocol 3, placebo, menthol, ilex, and menthol+ilex gels were applied to skin under local thermal control (34°C) both with and without sensory nerve blockage (topical lidocaine 4%). Post-occlusive reactive hyperemia (PORH) and local heating (42°C) protocols were conducted to determine the relative contribution of endothelium derived hyperpolarizing factors (EDHFs)/sensory nerves and nitric oxide (NO), respectively. Red cell flux was normalized to mean arterial pressure expressed as cutaneous vascular conductance (CVC: flux·mmHg(-1)) in all protocols. Topical menthol application increased SkBF compared to placebo (3.41±0.33 vs 1.1±0.19CVC: pmenthol (main effect, pmenthol application during PORH (3.62±0.29 vs. 2.50±0.21flux·mmHg(-1); pmenthol-mediated vasodilation at thermoneutral baseline (1.29±0.19flux·mmHg(-1

  18. Surgical excision margins for primary cutaneous melanoma.

    Science.gov (United States)

    Sladden, Michael J; Balch, Charles; Barzilai, David A; Berg, Daniel; Freiman, Anatoli; Handiside, Teenah; Hollis, Sally; Lens, Marko B; Thompson, John F

    2009-10-07

    Cutaneous melanoma accounts for 75% of skin cancer deaths. Standard treatment is surgical excision with a safety margin some distance from the borders of the primary tumour. The purpose of the safety margin is to remove both the complete primary tumour and any melanoma cells that might have spread into the surrounding skin.Excision margins are important because there could be trade-off between a better cosmetic result but poorer long-term survival if margins become too narrow. The optimal width of excision margins remains unclear. This uncertainty warrants systematic review. To assess the effects of different excision margins for primary cutaneous melanoma. In August 2009 we searched for relevant randomised trials in the Cochrane Skin Group Specialised Register; the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library (Issue 3, 2009), MEDLINE, EMBASE, LILACS, and other databases including Ongoing Trials Registers. We considered all randomised controlled trials (RCTs) of surgical excision of melanoma comparing different width excision margins. We assessed trial quality, and extracted and analysed data on survival and recurrence. We collected adverse effects information from included trials. We identified five trials. There were 1633 participants in the narrow excision margin group and 1664 in the wide excision margin group. Narrow margin definition ranged from 1 to 2 cm; wide margins ranged from 3 to 5 cm. Median follow-up ranged from 5 to 16 years. This systematic review summarises the evidence regarding width of excision margins for primary cutaneous melanoma. None of the five published trials, nor our meta-analysis, showed a statistically significant difference in overall survival between narrow or wide excision.The summary estimate for overall survival favoured wide excision by a small degree [Hazard Ratio 1.04; 95% confidence interval 0.95 to 1.15; P = 0.40], but the result was not significantly different. This result is compatible

  19. Les conditions d’exercice du travail des cadres de premier niveau : une étude de cas First level managers’ working conditions: a case study Las condiciones de ejercicio del trabajo de los supervisores de primer nivel : un estudio de caso

    Directory of Open Access Journals (Sweden)

    Geneviève Baril-Gingras

    2010-11-01

    Full Text Available Le travail des cadres de premier niveau a connu, ces dernières années, de nombreux changements. Dans le réseau de la santé au Québec, on a observé réduction importante de leur nombre de cadre de premier niveau. Or, ceux-ci jouent un rôle important quant à la santé (physique et psychologique et à la sécurité des membres des équipes de travail, puisqu’ils définissent certaines des conditions de réalisation de leur travail et certains aspects de leur environnement psychosocial de travail. L’étude, visant à mieux comprendre le travail de ces cadres et l’influence des conditions dans lesquelles il est réalisé, a procédé par des observations auprès de 12 cadres de premier niveau, sous forme de chroniques de travail et par des entretiens sur la base de ces observations. L’article présente et discute trois types de résultats : des exemples de la manière dont la tâche prescrite est convertie en tâche effective et de sa traduction dans leur activité ; une synthèse de la manière dont ils perçoivent leur rôle ou « tâche effective » ; des constats quant à l’écart entre celle-ci et les conditions de réalisation de leur travail, en particulier du fait d’une surcharge quantitative de travail, d’une autonomie réelle limitée et d’obstacles à la planification et au développement à long terme de leurs services, Ces conditions n’apparaissent donc pas favorables au rôle positif qu’ils souhaitent jouer et qui est attendu d’eux, par rapport à leurs équipes de travail.First-level managers’ work has undergone many changes in recent years. In Québec’s public health network, the number of these managers has decreased significantly. However, they play an important role in the health (physical and mental and safety of work team members, since they define some of their working conditions and some aspects of the psycho-social work environment. The aim of the study was to better understand first

  20. Optimizing topical antifungal therapy for superficial cutaneous fungal infections: focus on topical naftifine for cutaneous dermatophytosis.

    Science.gov (United States)

    Del Rosso, James Q; Kircik, Leon H

    2013-11-01

    Superficial cutaneous fungal infections (SCFIs) are commonly encountered in clinical practice in the United States, and comprise infections of the skin by dermatophytes and yeasts. The most common organisms causing SCFI are dermatophytes, especially Trichophyton spp. With the exception of onchomycosis and tinea capitis, most cases of SCFIs are amenable to properly selected topical antifungal therapy used over an adequate period of time. A variety of topical antifungal agents are available for the treatment of SCFIs, and they encompass a few major chemical classes: the polyenes (ie, nystatin), imidazoles (ie, ketoconazole, econazole, oxiconazole, etc), allylamines (ie, naftifine, terbinafine), benzylamines (ie, butenafine), and hydroxypyridones (ie, ciclopirox). The 2 major classes that represent the majority of available topical antifungal agents are the azoles and the allylamines. Overall, the allylamines are superior to the azoles in activity against dermatophytes, although both are clinically effective. The reverse is true against yeasts such as Candida spp and Malassezia spp, although topical allylamines have proven to be efficacious in some cases of tinea versicolor and cutaneous candidiasis. Naftifine, a topical allylamine, is fungicidal in vitro against a wide spectrum of dermatophyte fungi and has been shown to be highly effective against a variety of cutaneous dermatophyte infections. Rapid onset of clinical activity and favorable data on sustained clearance of infection have been documented with naftifine. The more recent addition of naftifine 2% cream has expanded the armamentarium, with data supporting a clinically relevant therapeutic reservoir effect after completion of therapy.

  1. Cutaneous Metastatic Undifferentiated Pleomorphic Sarcoma from a Mediastinal Sarcoma.

    Science.gov (United States)

    Jeong, Do Seon; Park, Dong Hwa; Kim, Chi Yeon

    2015-06-01

    Undifferentiated pleomorphic sarcoma, known as malignant fibrous histiocytoma, is a malignant neoplasm that arises in both soft tissue and bones. In 2002, the World Health Organization declassified malignant fibrous histocytoma as a formal diagnostic entity and renamed it 'undifferentiated pleomorphic sarcoma not otherwise specified.' It most commonly occurs in the lower extremities and rarely metastasizes cutaneously. We report a case of cutaneous metastatic undifferentiated pleomorphic sarcoma of the buttocks occurring in a 73-year-old man diagnosed with mediastinal sarcoma 4 years previously. He first noticed the mass approximately 2 months previously. Histological findings with immunomarkers led to a final diagnosis of cutaneous metastatic sarcoma from mediastinal undifferentiated pleomorphic sarcoma.

  2. Renal Cell Carcinoma Presenting with Cutaneous Metastasis: A Case Report

    Directory of Open Access Journals (Sweden)

    Nilufer Onak Kandemir

    2010-01-01

    Full Text Available Renal cell carcinoma is the most common kidney tumor in adults. Cutaneous metastasis is a rare first symptom of the disease. This paper describes the diagnosis of a renal cell carcinoma that was indicated by cutaneous metastasis in the head and neck region, and considers the etiopathogenesis of such cases. A careful skin examination is important to detect cutaneous metastasis associated with renal cell carcinomas. Metastatic skin lesions in the head and neck region must be taken into consideration during a differential diagnosis.

  3. Renal Cell Carcinoma Presenting with Cutaneous Metastasis: A Case Report

    Science.gov (United States)

    Onak Kandemir, Nilufer; Barut, Figen; Yılmaz, Kıvanç; Tokgoz, Husnu; Hosnuter, Mubin; Ozdamar, Sukru Oguz

    2010-01-01

    Renal cell carcinoma is the most common kidney tumor in adults. Cutaneous metastasis is a rare first symptom of the disease. This paper describes the diagnosis of a renal cell carcinoma that was indicated by cutaneous metastasis in the head and neck region, and considers the etiopathogenesis of such cases. A careful skin examination is important to detect cutaneous metastasis associated with renal cell carcinomas. Metastatic skin lesions in the head and neck region must be taken into consideration during a differential diagnosis. PMID:20811607

  4. Old World cutaneous leishmaniasis: diagnosis and treatment.

    Science.gov (United States)

    Masmoudi, Abderrahmen; Hariz, Wala; Marrekchi, Slaheddine; Amouri, Mariem; Turki, Hamida

    2013-06-30

    Cutaneous leishmaniasis is a major world health problem. Diagnosis is suspected on evocative clinical presentation in patients living in or coming from endemic areas. Several methods have been used. The smear is a simple investigation used in endemic regions. The culture enables to identify the specimen. PCR has a high sensitivity. Montenegro's reaction is used in the epidemiological study. Pentavalent antimony derivatives remain the mainstay of systemic treatment. Their efficiency is well established. Their toxicity should be researched. Other treatments can be utilized, such as miltefosine. Local therapy is used in uncomplicated lesions. Injections of the pentavalent antimony derivate, cryotherapy and paromomycin ointmentsis are important options and should be used more frequently in Old World leishmaniasis.

  5. Pattern of cutaneous manifestations in diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Goyal Abhishek

    2010-01-01

    Full Text Available Background: Diabetes mellitus affects individuals of all ages and socioeconomic status. Skin is affected by the acute metabolic derangements as well as by chronic degenerative complications of diabetes. Aims: To evaluate the prevalence of skin manifestations in patients with diabetes mellitus. To analyze the prevalence and pattern of skin disorders among diabetic patients from this region of Western Himalayas. Materials and Methods: One hundred consecutive patients with the diagnosis of diabetes mellitus and having skin lesions, either attending the diabetic clinic or admitted in medical wards were included in this study. Results: The common skin disorders were: x0 erosis (44%, diabetic dermopathy (36%, skin tags (32%, cutaneous infections (31%, and seborrheic keratosis (30%. Conclusion: Skin is involved in diabetes quite often and the manifestations are numerous. High prevalence of xerosis in our diabetic population is perhaps due to cold and dry climatic conditions in the region for most of the time in the year.

  6. Cutaneous chemical burns: assessment and early management.

    Science.gov (United States)

    Gnaneswaran, Neiraja; Perera, Eshini; Perera, Marlon; Sawhney, Raja

    2015-03-01

    Chemical burns are common and may cause significant physical, psychological, social and economic burden. Despite a wide variety of potentially harmful chemicals, important general principals may be drawn in the assessment and initial management of such injuries. Early treatment of chemical burns is crucial and may reduce the period of resulting morbidity. This article reviews the assessment and management of cutaneous chemical burns. Assessment of the patient should be rapid and occur in conjunction with early emergency management. Rapid history and pri-mary and secondary survey may be required to exclude systemic side effects of the injury. Depth of wound assessment is difficult given that necrosis caused by various chemicals can continue despite cessation of exposure. Early management should be conducted with consideration of clinician's safety, and appropriate precautions should be taken. Excluding specific situations and chemical exposure, copious irrigation with water remains the mainstay of early management. Referral to a centre of higher acuity may be required for expert evaluation.

  7. A rare cutaneous tumor: Dermatofibrosarcoma protuberans

    Directory of Open Access Journals (Sweden)

    Nuran Alli

    2017-10-01

    Full Text Available Dermatofibrosarcoma protuberans (DFSP is a rare indolent cutaneous tumor which has been considered as a low-grade dermal and subcutaneous fibrohistiocytic neoplasm. DFSP expands slowly but recurs frequently leading to the general assumption that DFSP is a locally aggressive neoplasm. This low-grade/borderline tumor which is generally found on trunk and proximal extremities of adults has limited potential for metastasis. Clinical presentation is usually typical with a red-brown or skin coloured indurated plaque with multiple nodules or protuberances. Histopathology of DFSP is also characteristical which demonstrates storiform pattern of uniform spindle cells infiltrating deep into the subcutaneous fat tissue constituting honeycomb appearence. Here, we report a case of DFSP in a 50-year-old woman who presents with a twenty year history of slowly growing mass on her left femoral area.

  8. Influence of microemulsions on cutaneous drug delivery

    DEFF Research Database (Denmark)

    Kreilgaard, Mads

    2002-01-01

    In attempt to increase cutaneous drug delivery, microemulsion vehicles have been more and more frequently employed over recent years. Microemulsion formulations have been shown to be superior for both transdermal and dermal delivery of particularly lipophilic compounds, but also hydrophilic...... compounds appear to benefit from application in microemulsions compared to conventional vehicles, like hydrogels, emulsions and liposomes. The favourable drug delivery properties of microemulsions appear to mainly be attributed to the excellent solubility properties. However, the vehicles may also act...... as penetration enhancers depending on the oil/surfactant constituents, which involves a risk of inducing local irritancy. The correlation between microemulsion structure/composition and drug delivery potential is not yet fully elucidated. However, a few studies have indicated that the internal structure...

  9. Cutaneous changes in fibrous hamartoma of infancy

    Directory of Open Access Journals (Sweden)

    Pilar F-Eire

    2013-01-01

    Full Text Available Only a few published case of fibrous hamartoma of infancy (FHI have commented on the changes in the overlying skin. There are descriptions of individual cases with cutaneous hyperpigmentation, hypertrichosis and hyperhidrosis. It is interesting to describe our case because, to our knowledge, the altered pigmentation of the overlying skin, with hairs on the surface, and eccrine gland hyperplasia combined with abortive hair follicles has not been reported together in association with the FHI. We recommend that all the biopsies must be excisional including overlying skin, thus the epidermal and dermal adnexal changes can be assessed in the microscopic evaluation which could have relevant implications from clinical and embryological point of view.

  10. Unusual Presentation of Cutaneous Leishmaniasis: Ocular Leishmaniasis

    Directory of Open Access Journals (Sweden)

    Masoud Doroodgar

    2017-01-01

    Full Text Available The leishmaniases are parasitic diseases that are transmitted to humans by infected female sandflies. Cutaneous leishmaniasis (CL is one of 3 main forms of the disease. CL is the most common form of the disease and is endemic in many urban and rural parts of Iran and usually caused by two species of Leishmania: L. major and L. tropica. We report a case of unusual leishmaniasis with 25 lesions on exposed parts of the body and right eyelid involvement (ocular leishmaniasis. The patient was a 75-year-old male farmer referred to health care center in Aran va Bidgol city. The disease was diagnosed by direct smear, culture, and PCR from the lesions. PCR was positive for Leishmania major.

  11. Proteome profiling of human cutaneous leishmaniasis lesion.

    Science.gov (United States)

    da Silva Santos, Claire; Attarha, Sanaz; Saini, Ravi Kanth; Boaventura, Viviane; Costa, Jackson; Khouri, Ricardo; Barral-Netto, Manoel; Brodskyn, Cláudia Ida; Souchelnytskyi, Serhiy

    2015-02-01

    In this study, we used proteomics and biological network analysis to evaluate the potential biological processes and components present in the identified proteins of biopsies from cutaneous leishmaniasis (CL) patients infected by Leishmania braziliensis in comparison with normal skin. We identified 59 proteins differently expressed in samples from infected and normal skin. Biological network analysis employing identified proteins showed the presence of networks that may be involved in the cell death mediated by cytotoxic T lymphocytes. After immunohistochemical analyses, the expression of caspase-9, caspase-3, and granzyme B was validated in the tissue and positively correlated with the lesion size in CL patients. In conclusion, this work identified differentially expressed proteins in the inflammatory site of CL, revealed enhanced expression of caspase-9, and highlighted mechanisms associated with the progression of tissue damage observed in lesions.

  12. Cutaneous and mucocutaneous leishmaniasis: Clinical perspectives.

    Science.gov (United States)

    Handler, Marc Z; Patel, Parimal A; Kapila, Rajendra; Al-Qubati, Yasin; Schwartz, Robert A

    2015-12-01

    Leishmaniasis is endemic in 98 countries and territories, with 1.2 million new cases per year, making it a worldwide concern. The deadly visceral form is a leading cause of death from tropical parasitic infections, second only to malaria. Leishmaniasis appears to be increasing in many countries because of extended urbanization. The disease reservoir includes small mammals; parasite transmission occurs via bite of the female phlebotomine sandfly. Disease manifestations vary and largely depend upon the Leishmania species acquired. It may be first evident with a range of findings-from a localized cutaneous ulcer to diffuse painless dermal nodules-or, in the mucocutaneous form, ulceration of the oropharynx. In the potentially deadly visceral form, the internal organs and bone marrow are affected. Copyright © 2014 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  13. Nevus lipomatosus cutaneous superficialis: Case report

    Directory of Open Access Journals (Sweden)

    İsmail Hamdi Kara

    2011-12-01

    Full Text Available Nevus lipomatosus cutaneous superficialis (NLS is arare skin malformation characterized by ectopic adipocytein upper dermis. It is composed of multiple nodular andpapular lesions localized especially on lower part of trunkand gluteal region. These lesions have linear and zosterform pattern. In our case, 42 years-old woman admitted toour clinic, presenting with non-painful and non-itchy bulkylesion gradually increased on her upper back region since5 years. On her examination, multiple nodulo-papular lesionswith zoster form pattern localized on lower marginof right scapular region were detected. It was diagnosedas NLS, depending on histopathological investigation.Treatment for NLS is cosmetically surgical excision, andthe patient’s lesion was excised, because it is benign lesion.J Clin Exp Invest 2011; 2 (4: 457-459

  14. Zika Virus: Cutaneous Manifestations in 3 Patients.

    Science.gov (United States)

    Cosano-Quero, A; Velasco-Tirado, V; Sánchez Seco, M P; Manzanedo-Bueno, L; Belhassen-García, M

    2017-07-03

    Zika virus infection should be suspected in travelers or immigrants with the signs or symptoms of a viral infection (rash, fever, joint pains, conjunctivitis, headache, etc.) and a compatible epidemiological history. Although cutaneous manifestations are among the most common clinical signs of Zika, they are not specific and very few images are available. We present 3 patients (2 travelers and 1 immigrant) in whom a rash was the presenting manifestation of Zika virus infection. Prompt diagnosis optimizes outcomes in these patients, improves the management of severe disease, and minimizes the risk of local transmission by Aedes albopictus, now a potential local vector for the virus due to its presence in areas along Spain's Mediterranean coast. Copyright © 2017 AEDV. Publicado por Elsevier España, S.L.U. All rights reserved.

  15. Sun behaviour after cutaneous malignant melanoma

    DEFF Research Database (Denmark)

    Idorn, L W; Datta, P; Heydenreich, J

    2013-01-01

    Background  It has been reported that patients with cutaneous malignant melanoma (CMM) can lower their risk of a second primary melanoma by limiting recreational sun exposure. Previous studies based on questionnaires and objective surrogate measurements indicate that before their diagnosis......, patients with CMM are exposed to higher ultraviolet radiation (UVR) doses than controls, followed by a reduction after diagnosis. Objectives  In a prospective, observational case-control study, we aimed to assess sun exposure after diagnosis of CMM by objective measurements to substantiate advice about sun...... months and 6 years before the start of the study. During a summer season participants filled in sun exposure diaries daily and wore personal electronic UVR dosimeters in a wristwatch that continuously measured time-stamped UVR doses in standard erythema dose. Results  The UVR dose of recently diagnosed...

  16. Proteome Profiling of Human Cutaneous Leishmaniasis Lesion

    Science.gov (United States)

    da Silva Santos, Claire; Attarha, Sanaz; Saini, Ravi Kanth; Boaventura, Viviane; Costa, Jackson; Khouri, Ricardo; Barral-Netto, Manoel; Brodskyn, Cláudia Ida; Souchelnytskyi, Serhiy

    2015-01-01

    In this study, we used proteomics and biological network analysis to evaluate the potential biological processes and components present in the identified proteins of biopsies from cutaneous leishmaniasis (CL) patients infected by Leishmania braziliensis in comparison with normal skin. We identified 59 proteins differently expressed in samples from infected and normal skin. Biological network analysis employing identified proteins showed the presence of networks that may be involved in the cell death mediated by cytotoxic T lymphocytes. After immunohistochemical analyses, the expression of caspase-9, caspase-3, and granzyme B was validated in the tissue and positively correlated with the lesion size in CL patients. In conclusion, this work identified differentially expressed proteins in the inflammatory site of CL, revealed enhanced expression of caspase-9, and highlighted mechanisms associated with the progression of tissue damage observed in lesions. PMID:25207817

  17. Inflammatory Cutaneous Diseases in Renal Transplant Recipients

    Directory of Open Access Journals (Sweden)

    Paola Savoia

    2016-08-01

    Full Text Available Kidney transplant recipients frequently suffer from skin infections and malignancies, possibly due to the effects of long-term immunosuppressive therapy. While the relationships between immunosuppression and these pathological conditions have been widely investigated, little is known about the relative incidence and characteristics of inflammatory skin diseases in this type of patient. In this study, we analyze the incidence of a number of inflammatory cutaneous diseases in a cohort of patients who underwent kidney transplantation. Although our study shows a relatively low incidence of these pathologies in transplanted patients—in agreement with the general action of immunosuppressant therapies in reducing inflammation—we scored a different efficacy of the various immunosuppressive regimens on inflammatory and autoimmune skin diseases. This information can be key for designing immunosuppressive regimens and devising accurate follow-up protocols.

  18. Treatments for Severe Cutaneous Adverse Reactions

    Directory of Open Access Journals (Sweden)

    Yung-Tsu Cho

    2017-01-01

    Full Text Available Severe cutaneous adverse reaction (SCAR is life-threatening. It consists of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN, drug reaction with eosinophilia and systemic symptoms (DRESS, acute generalized exanthematous pustulosis (AGEP, and generalized bullous fixed drug eruptions (GBFDE. In the past years, emerging studies have provided better understandings regarding the pathogenesis of these diseases. These diseases have unique presentations and distinct pathomechanisms. Therefore, theoretically, the options of treatments might be different among various SCARs. However, due to the rarity of these diseases, sufficient evidence is still lacking to support the best choice of treatment for patients with SCAR. Herein, we will provide a concise review with an emphasis on the characteristics and treatments of each SCAR. It may serve as a guidance based on the current best of knowledge and may shed light on the directions for further investigations.

  19. Treatments for Severe Cutaneous Adverse Reactions

    Science.gov (United States)

    Cho, Yung-Tsu

    2017-01-01

    Severe cutaneous adverse reaction (SCAR) is life-threatening. It consists of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP), and generalized bullous fixed drug eruptions (GBFDE). In the past years, emerging studies have provided better understandings regarding the pathogenesis of these diseases. These diseases have unique presentations and distinct pathomechanisms. Therefore, theoretically, the options of treatments might be different among various SCARs. However, due to the rarity of these diseases, sufficient evidence is still lacking to support the best choice of treatment for patients with SCAR. Herein, we will provide a concise review with an emphasis on the characteristics and treatments of each SCAR. It may serve as a guidance based on the current best of knowledge and may shed light on the directions for further investigations. PMID:29445753

  20. Ocular metastasis of cutaneous malignant melanoma.

    Science.gov (United States)

    Ullah, Tehseena; Gurwood, Andrew S; Myers, Marc D

    2009-10-01

    Metastatic melanoma to the eye and orbit are rare. Patients at greatest risk often have disseminated metastases in the setting of advanced disease. Because the prognosis for orbital metastatic disease is poor, emphasis must be placed on early detection and prevention. Although cutaneous malignancies include basal cell carcinoma, squamous cell carcinoma, sebaceous cell carcinoma, and malignant melanoma, the majority of cases that result in metastasis, ocular morbidity, and mortality are from sebaceous cell carcinoma and malignant melanoma. A 72-year-old white woman presented emergently with a chief complaint of sudden, painless vision loss in her left eye of 2 weeks' duration. Her best-corrected visual acuities measured 20/30 in the right eye and 20/400 in the left eye with no improvement on refraction. Her systemic medical history was significant for the diagnosis of a cutaneous malignant melanoma. Examination of the left eye found grade II disc edema with all other posterior pole and peripheral structures intact and unremarkable. Magnetic resonance imaging confirmed the diagnosis of metastatic lesions involving structures of the left orbit ultimately causing reduced visual ability. The patient opted to avoid aggressive care and "hope for the best." Denying significant medical intervention, the woman lived in hospice where she died 6 months later. The primary care optometric setting, by the way a patient's visual symptoms present or the appearance of fundus abnormalities, can offer the capability of first detection and referral for the discovery of metastatic lesions. Although orbital metastasis is considered a terminal finding in these cases, timely diagnosis enables, while limited, the best options for management.

  1. Blog and Podcast Watch: Cutaneous Emergencies

    Directory of Open Access Journals (Sweden)

    Andrew Grock

    2017-02-01

    Full Text Available The WestJEM Blog and Podcast Watch presents high quality open-access educational blogs and podcasts in emergency medicine (EM based on the ongoing Academic Life in Emergency Medicine (ALiEM Approved Instructional Resources (AIR and AIR-Professional series. Both series critically appraise resources using an objective scoring rubric. This installment of the Blog and Podcast Watch highlights the topic of cutaneous emergencies from the AIR series.    The AIR series is a continuously building curriculum that follows the Council of Emergency Medicine Residency Directors (CORD annual testing schedule. For each module, relevant content is collected from the top 50 most accessed sites per the Social Media Index published within the previous 12 months and scored by eight board members using five equally weighted measurement outcomes: Best Evidence in Emergency Medicine (BEEM score, accuracy, educational utility, evidence based, and references. Resources scoring ≥30 out of 35 available points receive an AIR label. Resources scoring 27-29 receive an “honorable mention” label, if the editorial board agrees that the post is accurate and educationally valuable. A total of 35 blog posts and podcasts were evaluated. None scored ≥30 points necessary for the AIR label, although four honorable mention posts were identified. Key educational pearls from these honorable mention posts are summarized. This Blog and Podcast Watch series is based on the AIR and AIR-Pro series, which attempts to identify high quality educational content on open-access blogs and podcasts. This series provides an expertbased, post-publication curation of educational social media content for EM clinicians with this installment focusing on cutaneous emergencies. [West J Emerg Med. 2017;18(2288-292.

  2. Transport characteristics in Au/pentacene/Au diodes

    Science.gov (United States)

    Hayashi, Toshiaki; Naka, Akiyoshi; Hiroki, Masanobu; Yokota, Tomoyuki; Someya, Takao; Fujiwara, Akira

    2018-03-01

    We have used scanning and transmission electron microscopes (SEM and TEM) to study the structure of a pentacene thin film grown on a Au layer with and shown that it consists of randomly oriented amorphous pentacene clusters. We have also investigated the transport properties of amorphous pentacene in a metal–semiconductor–metal (MSM) diode structure and shown that the current is logarithmically proportional to the square root of the applied voltage, which indicates that transport occurs as the result of hopping between localized sites randomly distributed in space and energy.

  3. Acces au traitement anticancereux au Togo (access to treatment of ...

    African Journals Online (AJOL)

    Contexte : Au Togo, l'incidence et la mortalité des cancers ne cessent de croître en raison du diagnostic et de la prise en charge tardifs. D'autres raisons telles que l'absence d'oncologue spécialiste et la faible accessibilité aux médicaments anticancéreux sont de plus en plus évoquées. L'objectif de cette étude était de ...

  4. Evolution des flores et de la végétation Tertiaires en Afrique, au nord de PEquateur

    Directory of Open Access Journals (Sweden)

    E. Boureau

    1983-12-01

    Full Text Available La repartition de la flore Tertiaire en Afrique, três différente de l’actuelle, se comprend si on tient compte de deux facteurs essentiels: la regression des mers épicontinentales vers le nord et la dérive du continent africain. II en résulte qu’á l'Eocêne inférieur, l’équateur se trouvait á environ 1 000 km au nord de sa position actuelle. Ces modifications aboutissent á des transformations importantes de l’environnement climatique et par consequent de la repartition des flores. Cela explique notamment la presence d’une mangrove en Libye avec Sonneratioxylon aubrevillei et en Egypte avec Nipa burtinii.La forêt dense est présente dans le Paléocêne du Tinrhert avec Entandrophragmoxylon normandii (comparable á l’actuel  Entandrophragma angolense. Les formations de foret dense, développées á l’Eocêne, surtout sur le rivage, sont suivies plus au sud, d’une savane qui s’étend davantage á I’Oligocêne et qui peut atteindre la mer. Cependant, on trouve encore en bordure de mer á l’Oligocêne, des espêces de forêt dense comme Entandrophragmoxylon magnieri (comparable á  Entandrophragma candollei espêce qui avoisine des dépóts deltaiques avec de grands troncs qui indiquent une flore plus sêche (Detarioxylon aegyptiacum, Combretoxylon bussonii et Pterocarpoxylon tibestiense (rapproché du Pterocarpus erinaceus de savane, mais parfois accompagnée de troncs de forêt-galerie (Atherospermoxylon aegyptiacum, Monimiacée. Au Miocene, l’assechement continue et la savane progresse. Les Palmiers apparaissent et des galeries forestieres subsistent, mais même á proximité de la mer, le biotope est sec au Miocene inférieur dans le Nord de l’Afrique. Ce n’est que vers le sud que la végétation hygrophile apparait au niveau du Tibesti avec Myristicoxylon vincentii. Ainsi. prês de la position présente de l’Equateur, la mangrove se retrouve au Sénégal dans le Paléogêne du Cap-Vert avec des pollens

  5. High-p(T) Tomography of d+Au and Au+Au at SPS, RHIC, and LHC.

    Science.gov (United States)

    Vitev, Ivan; Gyulassy, Miklos

    2002-12-16

    The interplay of nuclear effects on the p(T)>2 GeV inclusive hadron spectra in d+Au and Au+Au reactions at sqrt[s(NN)]=17, 200, and 5500 GeV is compared to leading order perturbative QCD calculations for elementary p+p (p+p) collisions. The competition between nuclear shadowing, Cronin effect, and jet energy loss due to medium-induced gluon radiation is predicted to lead to a striking energy dependence of the nuclear suppression/enhancement pattern in A+A reactions. We show that future d+Au data can be used to disentangle the initial and final state effects.

  6. Profiling hot and dense nuclear medium with high transverse momentum hadrons produced in d+Au and Au+Au collisions by the PHENIX experiment at RHIC

    Directory of Open Access Journals (Sweden)

    Sakaguchi Takao

    2014-03-01

    Full Text Available PHENIX measurements of high transverse momentum (pT identified hadrons in d+Au and Au+Au collisions are presented. The nuclear modification factors (RdA and RAA for π0 and ƞ are found to be very consistent in both collision systems, respectively. Using large amount of p + p and Au+Au datasets, the fractional momentum loss (Sloss and the path-length dependent yield of π0 in Au+Au collisions are obtained. The hadron spectra in the most central d+Au and the most peripheral Au+Au collisions are studied. The spectra shapes are found to be similar in both systems, but the yield is suppressed in the most peripheral Au+Au collisions.

  7. Au38(SPh)24: Au38 Protected with Aromatic Thiolate Ligands.

    Science.gov (United States)

    Rambukwella, Milan; Burrage, Shayna; Neubrander, Marie; Baseggio, Oscar; Aprà, Edoardo; Stener, Mauro; Fortunelli, Alessandro; Dass, Amala

    2017-04-06

    Au38(SR)24 is one of the most extensively investigated gold nanomolecules along with Au25(SR)18 and Au144(SR)60. However, so far it has only been prepared using aliphatic-like ligands, where R = -SC6H13, -SC12H25 and -SCH2CH2Ph. Au38(SCH2CH2Ph)24 when reacted with HSPh undergoes core-size conversion to Au36(SPh)24, and existing literature suggests that Au38(SPh)24 cannot be synthesized. Here, contrary to prevailing knowledge, we demonstrate that Au38(SPh)24 can be prepared if the ligand exchanged conditions are optimized, under delicate conditions, without any formation of Au36(SPh)24. Conclusive evidence is presented in the form of matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), electrospray ionization mass spectra (ESI-MS) characterization, and optical spectra of Au38(SPh)24 in a solid glass form showing distinct differences from that of Au38(S-aliphatic)24. Theoretical analysis confirms experimental assignment of the optical spectrum and shows that the stability of Au38(SPh)24 is not negligible with respect to that of its aliphatic analogous, and contains a significant component of ligand-ligand attractive interactions. Thus, while Au38(SPh)24 is stable at RT, it converts to Au36(SPh)24 either on prolonged etching (longer than 2 hours) at RT or when etched at 80 °C.

  8. Hereditary leiomyomatosis and renal cell cancer: Cutaneous lesions & atypical fibroids

    Directory of Open Access Journals (Sweden)

    Pietro Bortoletto

    2017-07-01

    Precis: 27-year-old woman with multiple cutaneous lesions is found to have uterine leiomyomas and undergoes robotic myomectomy. Genetic testing of uterine leiomyomas reveals mutation in fumarate hydratase, etiologic in hereditary leiomyomatosis and renal cell cancer (HLRCC.

  9. Cutaneous horn and thermal keratosis in erythema AB igne

    Directory of Open Access Journals (Sweden)

    Sood Apra

    2002-01-01

    Full Text Available A 46 - year - old Kashmiri lady developed erythema ab igne on both legs. She subsequently developed multiple keratoses and a cutaneous horn in the involved skin. An uncommon association of these three clinical conditions is being presented.

  10. Cutaneous leishmaniasis with lymphadenopathy due to Leishmania donovani

    NARCIS (Netherlands)

    Faber, W. R.; Wonders, J.; Jensema, A. J.; Chocholova, E.; Kager, P. A.

    2009-01-01

    Summary We describe a case of cutaneous leishmaniasis with lymphadenopathy due to Leishmania donovani, which was successfully treated with oral miltefosine. Given the increased prevalence of travelling, patients presenting with lymph-node enlargement should have leishmaniasis included in the

  11. Naloxone prolongs cutaneous nociceptive block by lidocaine in rats.

    Science.gov (United States)

    Chen, Yu-Wen; Shieh, Ja-Ping; Liu, Kuo-Sheng; Wang, Jhi-Joung; Hung, Ching-Hsia

    2017-12-01

    We aimed to investigate the local anesthetic properties of naloxone alone or as an adjunct for the local anesthetic lidocaine. After the block of the cutaneous trunci muscle reflex (CTMR) with drugs delivery by subcutaneous infiltration, cutaneous nociceptive block was tested on the ratsꞌ backs. We demonstrated that naloxone, as well as lidocaine, elicited cutaneous analgesia dose-dependently. The relative potency in inducing cutaneous analgesia was lidocaine [22.6 (20.1 - 25.4) μmol/kg] > naloxone [43.2 (40.3 - 46.4) μmol/kg] (P block (P block. © 2017 Société Française de Pharmacologie et de Thérapeutique.

  12. Two Cases of Cutaneous Leishmaniasis Seen in Trivandrum

    Directory of Open Access Journals (Sweden)

    M Lohidakshan Unnithen

    1988-01-01

    Full Text Available Two cases of cutaneous leishmaniasis in Trivandrum acquired the infection while residing in Saudi Arabia. One patient responded to trivalent antimony (Fantorin and the other to dapsone.

  13. Diet phytochemicals and cutaneous carcinoma chemoprevention: A review.

    Science.gov (United States)

    Wang, Siliang; Shen, Peiliang; Zhou, Jinrong; Lu, Yin

    2017-05-01

    Cutaneous carcinoma, which has occupied a peculiar place among worldwide populations, is commonly responsible for the considerably increasing morbidity and mortality rates. Currently available medical procedures fail to completely avoid cutaneous carcinoma development or to prevent mortality. Cancer chemoprevention, as an alternative strategy, is being considered to reduce the incidence and burden of cancers through chemical agents. Derived from dietary foods, phytochemicals have become safe and reliable compounds for the chemoprevention of cutaneous carcinoma by relieving multiple pathological processes, including oxidative damage, epigenetic alteration, chronic inflammation, angiogenesis, etc. In this review, we presented comprehensive knowledges, main molecular mechanisms for the initiation and development of cutaneous carcinoma as well as effects of various diet phytochemicals on chemoprevention. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. Primary cutaneous cryptococcosis in an immunocompetent man: A case report

    Directory of Open Access Journals (Sweden)

    Ying-Yi Lu

    2013-06-01

    Full Text Available Cutaneous cryptococcosis usually develops secondary to hematogenous spread in immunocompromised hosts. Primary cutaneous cryptococcosis (PCC is a rare condition characterized by localized skin eruptions and positive culture for Cryptococcus neoformans but without dissemination to the internal organs. Herein, we describe a typical case of PCC in an immunocompetent male who presented with a 1-month history of scattered erythematous indurated papules and plaques on his arm and without fever. The histology of his skin, tissue culture, and multiplex polymerase chain reaction (PCR confirmed cutaneous cryptococcal infection by C neoformans var. neoformans. After extensive work-ups showed no evidence of systemic dissemination or underlying cellular-immunity deficiency, the diagnosis of primary cutaneous cryptococcosis was made. Treatment with fluconazole 400 mg daily for 14 days followed by 200 mg daily for another 14 days led to complete resolution of the skin lesions, and subsequent follow-up showed no signs of relapse.

  15. Représentations autour du niveau de langue : le cas du français à l’université

    Directory of Open Access Journals (Sweden)

    Nabil Sadi

    2013-05-01

    Full Text Available Cet article a pour objectif d'étudier le français parlé par les étudiants algériens. Il vise, à travers deux volets, à étudier le niveau de ces étudiants en langue française, tel qu’il est décrit par les enseignants, et sur ce qui le caractérise tant à l’oral qu’à l’écrit, ainsi que les procédés de dénomination utilisés par les enseignants pour qualifier le français des étudiants de l’université de Bejaia. Il s’agit de décrire les différents termes employés pour nommer ce français parlé, déterminer les différentes formes sous lesquelles apparaissent ces divers qualifiants et faire ressortir les facteurs qui régissent le choix de ces termes. Avant de répondre à ces questions, nous mettrons l’accent essentiellement sur le français dans l’Algérie d’aujourd’hui en retraçant son cheminement depuis l’occupation française jusqu’après l’indépendance. Nous ne manquerons pas de décrire l’aventure de cette langue dans un environnement plurilingue et d’évoquer son statut ainsi que ses domaines d’usage, sans trop insister sur ce qui caractérise la situation sociolinguistique de l’Algérie.

  16. Association of Piebaldism, Multiple Café-au-lait Macules, and Intertriginous Freckling: Clinical Evidence for a Common Pathway between KIT and SPRED1

    Science.gov (United States)

    Chiu, Yvonne E.; Dugan, Stefanie; Basel, Donald; Siegel, Dawn H.

    2014-01-01

    Piebaldism is a rare genodermatosis caused by KIT mutations. We report the case of a 5-year-old boy who had the white forelock and leukoderma of piebaldism, yet the diagnosis was complicated by the presence of many café-au-lait macules and axillary and inguinal freckling. Patients with similar cutaneous findings have been previously reported, and their disorder has been attributed to an overlap of piebaldism and neurofibromatosis type 1. Legius syndrome is a recently described syndrome caused by SPRED1 mutations that also has multiple café-au-lait macules and intertriginous freckling. Based on current understanding of KIT and SPRED1 protein interactions, we propose that café-au-lait macules and freckling may be seen in some patients with piebaldism and does not necessarily represent co-existence of neurofibromatosis type 1. PMID:23016555

  17. Genre et migration au Maroc

    OpenAIRE

    KHACHANI, Mohamed

    2011-01-01

    Euro-Mediterranean Consortium for Applied Research on International Migration (CARIM) Une des principales caractéristiques récentes de la migration marocaine est sa tendance à une féminisation soutenue. Le projet migratoire - qui était un projet d’hommes - intéresse de plus en plus les femmes marocaines au point de constituer actuellement près de la moitié de l’effectif migratoire marocain. Cette reconnaissance de l'importance des femmes dans la construction de l'espace migratoire a placé ...

  18. Genre et migration au Liban

    OpenAIRE

    JOUNI, Hassan

    2011-01-01

    Euro-Mediterranean Consortium for Applied Research on International Migration (CARIM) La femme possède un statut bien avancé au sein de la société libanaise : la Constitution libanaise proclame l’égalité entre les citoyens. Quelques lois et pratiques restent, toutefois, discriminatoires à l’égard de la femme, notamment la loi sur la nationalité et la loi sur le statut personnel. Une discrimination sociale très grave existe en ce qui concerne les femmes travaillant à domicile; elles subi...

  19. Cutaneous Mycobacterium abscessus Infection Associated with Mesotherapy Injection

    Directory of Open Access Journals (Sweden)

    Pranee Wongkitisophon

    2011-02-01

    Full Text Available Non-tuberculous mycobacterial skin infections have an increasing incidence. In immunocompetent patients, they usually follow local trauma. We present a case of cutaneous Mycobacterium abscessus infection following mesotherapy. The lesions were successfully treated with a combination of clarithromycin, ciprofloxacin, and doxycycline. Atypical mycobacterial infection should be suspected in patients who develop late-onset skin and soft tissue infection after cutaneous injury, injection, and surgical intervention, particularly if they do not respond to conventional antibiotic treatment.

  20. Cutaneous Mycobacterium abscessus Infection Associated with Mesotherapy Injection.

    Science.gov (United States)

    Wongkitisophon, Pranee; Rattanakaemakorn, Ploysyne; Tanrattanakorn, Somsak; Vachiramon, Vasanop

    2011-02-18

    Non-tuberculous mycobacterial skin infections have an increasing incidence. In immunocompetent patients, they usually follow local trauma. We present a case of cutaneous Mycobacterium abscessus infection following mesotherapy. The lesions were successfully treated with a combination of clarithromycin, ciprofloxacin, and doxycycline. Atypical mycobacterial infection should be suspected in patients who develop late-onset skin and soft tissue infection after cutaneous injury, injection, and surgical intervention, particularly if they do not respond to conventional antibiotic treatment.

  1. Melanoma inhibitory activity in Brazilian patients with cutaneous melanoma*

    OpenAIRE

    Odashiro, Macanori; Hans Filho, Gunter; Pereira,Patricia Rusa; Castro, Ana Rita Coimbra Motta de; Stief, Alcione Cavalheiro; Pontes, Elenir Rose Jardim Cury; Odashiro, Alexandre Nakao

    2015-01-01

    Abstract BACKGROUND: Melanoma inhibitory activity is a protein secreted by melanoma cells and has been used as a tumor marker. Increased Melanoma inhibitory activity serum levels are related to metastatic disease or tumor recurrence. Currently there are no studies on Melanoma inhibitory activity and cutaneous melanoma involving Brazilian patients. OBJECTIVE: To evaluate the performance and feasibility of measuring Melanoma inhibitory activity levels in Brazilian patients with cutaneous melano...

  2. Cutaneous Metastatic Undifferentiated Pleomorphic Sarcoma from a Mediastinal Sarcoma

    OpenAIRE

    Jeong, Do Seon; Park, Dong Hwa; Kim, Chi Yeon

    2015-01-01

    Undifferentiated pleomorphic sarcoma, known as malignant fibrous histiocytoma, is a malignant neoplasm that arises in both soft tissue and bones. In 2002, the World Health Organization declassified malignant fibrous histocytoma as a formal diagnostic entity and renamed it 'undifferentiated pleomorphic sarcoma not otherwise specified.' It most commonly occurs in the lower extremities and rarely metastasizes cutaneously. We report a case of cutaneous metastatic undifferentiated pleomorphic sarc...

  3. Cutaneous myiasis due to Dermatobia hominis in Saudis.

    Science.gov (United States)

    Akhter, J; Qadri, S M; Imam, A M

    2000-07-01

    Cutaneous myiasis infestations are normally found in South and Central America but increasing travel has resulted in their spread to non-indigenous countries with increasing frequency. We report two cases of cutaneous infestation by Dermatobia hominis in Taif, Saudi Arabia. There was no history of travel outside Saudi Arabia. The source of infection appears to be domestic cattle indicating that these infestations may be endemic in this region.

  4. Thermotherapy. An alternative for the treatment of American cutaneous leishmaniasis.

    OpenAIRE

    López, Liliana; Robayo, Martha; Vargas, Margarita; Vélez, Iván D

    2012-01-01

    Abstract Background Pentavalent antimonials (Sb5) and miltefosine are the first-line drugs for treating cutaneous leishmaniasis in Colombia; however, toxicity and treatment duration negatively impact compliance and cost, justifying an active search for better therapeutic options. We compared the efficacy and safety of thermotherapy and meglumine antimoniate for the treatment of cutaneous leishmaniasis in Colombia. Method An open randomized Phase III clinical trial was performed in five milita...

  5. Disseminated cutaneous Mycobacterium tuberculosis infection in a patient with AIDS.

    Science.gov (United States)

    Corbett, E L; Crossley, I; De Cock, K M; Miller, R F

    1995-01-01

    Individuals infected with the human immunodeficiency virus (HIV) are at an increased risk of both pulmonary and extrapulmonary tuberculosis. Disseminated cutaneous tuberculosis is rare, but has been reported in four HIV-positive patients, all of whom also had pulmonary infection. In this report we describe an HIV-infected patient with a febrile illness and an abnormal chest radiograph who developed widespread cutaneous tuberculous pustules following a lymph node biopsy on the previous day. Images PMID:7490048

  6. Nuclear Data Sheets for 181Au

    Science.gov (United States)

    Baglin, Coral M.

    1999-06-01

    Nuclear structure data pertaining to 181Au have been compiled and evaluated, and incorporated into the ENSDF data file. This evaluation of 181Au supersedes the previous publication (R. B. Firestone, Nuclear Data Sheets 62, 101 (1991) (literature cutoff date October 1990)), and includes literature available by 2 July 1999. The newly incorporated references are: 1999Mu05, 1999So01, 1995Au04, 1995Bi01, 1991Ry01, 1979Ha10, 1970Ha18.

  7. Nuclear data sheets for 181Au

    Energy Technology Data Exchange (ETDEWEB)

    Baglin, Coral M.

    1999-07-02

    Nuclear structure data pertaining to 181Au have been compiled and evaluated, and incorporated into the ENSDF data file. This evaluation of 181Au supersedes the previous publication (R. B. Firestone, Nuclear Data Sheets 62, 101 (1991) (literature cutoff date October 1990)), and includes literature available by 2 July 1999. The newly incorporated references are: 1999Mu05, 1999So01, 1995Au04, 1995Bi01, 1991Ry01, 1979Ha10, 1970Ha18.

  8. Predicted Habitat Suitability for Montipora Corals in the Au'au Channel Region

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This raster denotes predicted habitat suitability for Montipora in the Au'au Channel region. Maximum Entropy (MaxEnt) modeling software was used to create this...

  9. Predicted Habitat Suitability for Porites in the Au'au Channel Region

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This raster denotes predicted habitat suitability for Porites in the Au'au Channel region. Maximum Entropy (MaxEnt) modeling software was used to create this...

  10. Predicted Habitat Suitability for Porites Corals in the Au'au Channel Region

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This raster denotes predicted habitat suitability for Porites in the Au'au Channel region. Maximum Entropy (MaxEnt) modeling software was used to create this...

  11. Predicted Habitat Suitability for Leptoseris Corals in the Au'au Channel Region

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This raster denotes predicted habitat suitability for Leptoseris in the Au'au Channel region. Maximum Entropy (MaxEnt) modeling software was used to create this...

  12. Predicted Habitat Suitability for All Mesophotic Corals in the Au'au Channel Region

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This raster denotes predicted habitat suitability for all mesophotic corals in the Au'au Channel region. Maximum Entropy (MaxEnt) modeling software was used to...

  13. Predicted Habitat Suitability for Leptoseris in the Au'au Channel Region

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This raster denotes predicted habitat suitability for Leptoseris in the Au'au Channel region. Maximum Entropy (MaxEnt) modeling software was used to create this...

  14. Predicted Habitat Suitability for All Mesophotic Corals in the Au'au Channel Region

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset is located between the islands of Maui, Lanai, Molokai and Kahoolawe, and includes the Au'au Channel as well as parts of the Kealaikahiki, Alalakeiki...

  15. Cutaneous side effects of doxycycline: a pediatric case series.

    Science.gov (United States)

    Bayhan, Gulsum Iclal; Akbayram, Sinan; Ozaydin Yavuz, Goknur; Oner, Ahmet Fayik

    2017-06-01

    Brucellosis is highly endemic in Turkey and doxycycline is commonly used for its treatment. The present study aimed at documenting the cutaneous side effects of doxycycline in pediatric brucellosis patients in Turkey. Pediatric patients with brucellosis that were treated between February 2014 and January 2016 were analyzed retrospectively, and those that developed doxycycline-related cutaneous side effects were identified. Demographic data, epidemiological history, physical examination findings, laboratory test results, anti-brucellosis treatment regimen, duration of follow up and outcome were recorded. Among the 189 brucellosis patients, 141 treated with doxycycline plus rifampicin. Seven patients (5%) (two female and five male) developed doxycycline-related cutaneous side effects. Mean duration of treatment before the onset of cutaneous side effects was 9.5 weeks. Doxycycline therapy was continued in five of these patients and was changed in two patients. In the patients that continued to receive doxycycline the cutaneous side effects gradually improved. Cutaneous side effects of doxycycline should always be a consideration, especially in regions in which brucellosis is endemic and doxycycline is commonly used to treat it.

  16. [Cutaneous tuberculosis in an area of Mallorca (2003-2011)].

    Science.gov (United States)

    Losada-López, I; García-Gasalla, M; Taberner, R; Cifuentes-Luna, C; Arquinio, L; Terrasa, F; Pérez, M C

    2012-04-01

    Tuberculosis is an important health care problem, even in our setting. The objective of this study is to describe clinic and epidemiological features of cutaneous tuberculosis in our area. A retrospective study was performed of all patients diagnosed of cutaneous tuberculosis in a hospital in Mallorca (Spain) from January 2003 to July 2011. The clinical forms, diagnostic methods used, treatment used and clinical course were recorded. Twenty-eight cases of cutaneous tuberculosis were diagnosed (5.9% of the tuberculosis cases diagnosed in this period), 15 with classic cutaneous tuberculosis (14 scrofuloderma, 1 empyema necessitatis) and 13 patients with tuberculids (8 erythema induratum of Bazin disease and 5 erythema nodosum). Scrofulodermas came from lymph nodes in 10 of the patients, infected bone in 4 and pleural in one case; 13/28 patients came from other continents. Most of the patients were treatment with 3-4 tuberculostatic drugs, with favorable course. Cutaneous tuberculosis is not uncommon in our setting. In classic cutaneous tuberculosis culture is the gold standard diagnostic method while tuberculids are most commonly diagnosed by histology. Copyright © 2011 Elsevier España, S.L. All rights reserved.

  17. Aspects épidémiologiques, diagnostiques et thérapeutiques des ostéosarcomes de l'enfant au CHU Aristide le Dantec de Dakar: à propos de 16 cas

    Science.gov (United States)

    Ndour, Oumar; Alumeti, Desire Munyali; Fall, Mbaye; Fall, Aimée Faye; Diouf, Cheikh; Ndoye, Ndeye Aby; Ngom, Gabriel; Ndoye, Mamadou

    2013-01-01

    Le but de cette étude était de décrire les aspects épidémiologiques, diagnostiques et thérapeutiques des ostéosarcomes de l'enfant. Il s'agissait d'une étude rétrospective sur dix ans qui a colligé 16 dossiers d'ostéosarcome pris en charge au service de Chirurgie Pédiatrique de l'hôpital Aristide Le Dantec de Dakar. Les paramètres étudiés étaient le niveau d'instruction et le niveau socioprofessionnel des parents, l'origine géographique, l’âge, le sexe, les antécédents particuliers, le délai de consultation, les motifs de consultation, les signes physiques, les signes radiologiques, la biologie, les modalités thérapeutiques et l’évolution. Tous les patients avaient bénéficié d'un examen anatomopathologique qui a confirmé le diagnostic d'ostéosarcome. Pour la majeure partie de nos patients (58% des cas) les parents avaient un niveau d'instruction bas. L’âge moyen était de 11ans. Une prédominance masculine était retrouvée avec un sex-ratio de 3,25:1. Le délai de consultation moyen était de 16 mois. Le principal motif de consultation était la tuméfaction (10 cas). Huit patients avaient bénéficié d'un traitement traditionnel. La taille de la tumeur était supérieure à 10cm dans 14 cas. La localisation la plus fréquente était le genou (14 cas). La radiographie standard retrouvait dans 15 cas des images d'ostéolyse. Le bilan d'extension n'avait pas retrouvé de métastases. Les options thérapeutiques étaient dominées par l'amputation seule (43,75% des cas). La survie à 2 ans était de 17%. L'ostéosarcome atteint le plus souvent le garçon après l’âge de 10 ans. Sa prise en charge au Sénégal se heurte à d’énormes difficultés liées au retard diagnostique. La solution repose essentiellement sur une collaboration pluridisciplinaire. PMID:23720705

  18. Interventions for American cutaneous and mucocutaneous leishmaniasis.

    Science.gov (United States)

    González, Urbà; Pinart, Mariona; Rengifo-Pardo, Mónica; Macaya, Antonio; Alvar, Jorge; Tweed, John A

    2009-04-15

    Pentavalent antimonial drugs are the most prescribed treatment for American cutaneous and mucocutaneous leishmaniasis. Other drugs have been used with varying success. To assess the effects of therapeutic interventions for American cutaneous and mucocutaneous leishmaniasis. We searched the Cochrane Skin Group Specialised Register (January 2009), the Register of Controlled Clinical Trials in The Cochrane Library (Issue 1,2009), MEDLINE (2003 to January 2009), EMBASE (2005 to January 2009), LILACS (from inception to January 2009), CINAHL (1982-May 2007) and other databases. Randomised controlled trials (RCTs) assessing treatments for American cutaneous and mucocutaneous leishmaniasis. Two authors independently assessed trial quality and extracted data. We included 38 trials involving 2728 participants. Results are based on individual studies or limited pooled analyses. There was good evidence in:Leishmania braziliensis and L. panamensis infections:Intramuscular (IM) meglumine antimoniate (MA) was better than oral allopurinol for 28 days (1RCT n=127, RR 0.39; 95% CI 0.26, 0.58). Intravenous (IV)MA for 20-days was better than 3-day and 7-day IVMA plus 15% paromomycin plus 12% methylbenzethonium chloride (PR-MBCL) or 7-day IVMA (1RCT n= 150, RR 0.24; 95% CI 0.11, 0.50; RR 0.69; 95% CI 0.53, 0.90; RR 0.64; 95% CI 0.44, 0.92 respectively). Oral allopurinol plus antimonials was better than IV antimonials (2RCT n= 168, RR 1.90; 95% CI 1.40, 2.59; I(2)=0%).L. braziliensis infections:Oral pentoxifylline plus IV sodium stibogluconate (SSG) was better than IVSSG (1RCT n= 23, RR 1.66; 95% CI 1.03, 2.69); IVMA was better than IM aminosidine sulphate (1RCT n= 38, RR 0.05; 95% CI 0.00, 0.78) and better than IV pentamidine isethionate (1RCT n= 80, RR 0.45; 95% CI 0.29, 0.71). Intramuscular MA was better than Bacillus Calmette-Guérin (1RCT n= 93, RR 0.46; 95% CI 0.32, 0.65).L .panamensis infections:Oral allopurinol was better than IVMA (1RCT n= 58, RR 2.20; 95% CI 1.34, 3

  19. Genetic study of familial uveal melanoma: association of uveal and cutaneous melanoma with cutaneous and ocular nevi.

    Science.gov (United States)

    Smith, Jennifer H; Padnick-Silver, Lissa; Newlin, Anna; Rhodes, Katrina; Rubinstein, Wendy S

    2007-04-01

    To evaluate a kindred with familial uveal and cutaneous melanoma and to identify potential genetic and environmental factors that may predispose individuals to develop uveal melanoma. Family-based case report with detailed clinical and genetic evaluation. Ten siblings in a single nuclear family. Evaluation of a large sibship via family history, complete eye and skin examinations, environmental risk factor questionnaire, and genetic testing, as well as a MEDLINE search of familial uveal melanoma kindreds. Cutaneous and ocular nevi, benign and malignant neoplasms of skin and other sites, brief skin cancer risk assessment tool risk classification for cutaneous melanoma, DNA sequencing of p16INK4a and p14ARF genes, and citations on familial uveal melanoma. The proband and his mother had uveal melanoma, 3 cutaneous melanomas occurred among 2 siblings, and 2 other siblings had basal cell carcinomas. No germline mutations were detected in the melanoma-associated tumor suppressor genes p16INK4a and p14ARF. Seven out of 10 siblings had a history of cutaneous and/or ocular nevi. Of the 3 subjects without nevi, 2 had histories of eye or skin malignancies (1 uveal melanoma, 1 basal cell carcinoma). Three of the 10 siblings had relevant ocular findings (2 choroidal nevi, 1 uveal melanoma). Six were also found to be in the "high-risk" classification for cutaneous malignancies based on scores from a previously validated risk assessment tool. This family, combined with the 91 previously reported familial uveal melanoma kindreds, brings to 92 the total number thus far recorded. Our results strengthen the association between uveal melanoma, atypical nevi, and cutaneous melanoma. This relationship supports the recommendation that individuals with a personal or family history of uveal melanoma, particularly in combination with atypical nevi, should be regularly screened for uveal and cutaneous melanoma.

  20. PHENIX results on collectivity in high-multiplicity p + Au, d + Au and 3He + Au collisions

    Science.gov (United States)

    Xu, Qiao

    2016-08-01

    We present recent PHENIX results for long-range two-particle correlation functions across a large pseudorapidity(η) gap in high-multiplicity p+Au, d+Au and 3He+Au collisions. Enhanced correlations are observed for particles with small azimuthal separation. Measurements of the second order Fourier coefficients (v 2) in p/d/3He+Au collisions, and the third order Fourier coefficient (v 3) in 3He+Au collision are performed using the event plane method. Scaling of v 2 with the initial eccentricity (ɛ 2) is performed in each system to investigate the role of the initial geometry in the development of a final-state anisotropy in the particle emission. The v 2 coefficients for identified π±, K± and (anti-)proton are measured as a function of transverse kinetic energy (KET) and their magnitudes are found to scale approximately with the number of constituent quarks in the hadron.

  1. Cutaneous fungal infections in the elderly.

    Science.gov (United States)

    Loo, Daniel S

    2004-01-01

    Because of impaired host defenses and a favorable environment at specific anatomic sites, there is an increased prevalence of seborrheic dermatitis, mucosal and cutaneous candidiasis, tinea pedis, and onychomycosis in the geriatric population compared with other age groups. Both KOH and fungal culture are timely, convenient, and cost-effective methods of diagnosis. Sensitivity of these tests depends on proper technique for specimen collection and experience. KOH 20% with DMSO and DTM are highly recommended. Treatment should be tailored to the diagnosis and the individual patient. This includes the targeted spectrum of coverage (dermatophyte or yeast); topical versus systemic therapy; review of the patient's medication list for potential drug interactions; and likelihood of compliance. Checking baseline laboratories and routine monitoring of complete blood count and liver function tests in healthy patients, without a history of liver disease or active hepatitis, and without potential drug interactions, seems unwarranted for rare adverse events. Successful management requires adequate patient education, correction of underlying predisposing factors, and prophylactic measures against recurrence.

  2. Epidemiological aspects of cutaneous malignant melanoma (review).

    Science.gov (United States)

    Serraino, D; Fratino, L; Gianni, W; Campisi, C; Pietropaolo, M; Trimarco, G; Marigliano, V

    1998-01-01

    There is an increasing interest in the etiology of cutaneous malignant melanoma (CMM). Once considered a rare tumour, CMM is now the fourth commonest cancer in Australia and New Zeland, the tenth in the Usa, Canada and Scandinavia and the eighteenth in Great Britain. The growing scientific concern on the urgent need to highlight the cause/s of CMM is well documented by the large number of well-designed and well-conducted epidemiological studies reported in the last two decades. Such studies facilitated testing of many etiological hypotheses derived from earlier descriptive investigations and contributed to significant progress in understanding the etiology of such disease. The quantification of the extent to which the increases in CMM incidence and mortality rates are related to new lifestyles and to new patterns of exposure to potential carcinogenetic agents is essential in order to establish an appropriate preventive strategy. In population of mainly European origin a substantial proportion of the increased incidence of CMM is attributable to steady change from predominantly occupational to predominantly recreational exposure to solar radiation. Therefore the present review puts particular emphasis on exposure to sunlight as well as to artificial ultraviolet light, as modifiable causes of CMM. Incidence and mortality data and other potential risk factors for the development of CMM will also be briefly reviewed.

  3. A case of cutaneous odontogenic sinus.

    Science.gov (United States)

    Yasui, Hiroo; Yamaguchi, Michiya; Ichimiya, Makoto; Yoshikawa, Yoshiaki; Hamamoto, Yoshiaki; Muto, Masahiko

    2005-10-01

    Despite the fact that cutaneous sinus tracts of odontogenic origin are well documented, the condition is still commonly misdiagnosed, because chronic periapical periodontitis may be asymptomatic and is rarely open to the skin. A 75-year-old Japanese woman presented to our clinic with the chief complaint of a left cheek skin lesion with mild pain. Physical examination revealed a subcutaneous nodule covered with erythematous skin on her left buccal region. Cultures from the subcutaneous nodule grew Bacteroides species and Peptostreptococcus micros but did not yield acid-fast bacilli, fungi, or Actinomyces. Stains of smeared pus showed a considerable number of Gram-negative rods. The histopathological examination revealed a focal abscess formation in the lower dermis and subcutaneous tissue. Dental evaluation, including an orthopantogram, showed a radiolucent alveolar area at the left lower first molar apex, suggesting a periapical abscess. Antibiotic therapy for three weeks associated with surgical root canal therapy eliminated the subcutaneous nodule. A high degree of suspicion is required to correctly diagnose a lower facial lesion as being of odontogenic origin, and prompt dental evaluation should be considered.

  4. Dorsal ulnar cutaneous nerve conduction: reference values

    Directory of Open Access Journals (Sweden)

    Garibaldi Solange G.

    2002-01-01

    Full Text Available We investigated the reference values of the dorsal ulnar cutaneous nerve (DUC sensory nerve conduction (SNC in 66 healthy individuals. Measurements were processed using stimulating electrodes positioned between the ulnar bone and the flexor carpi ulnaris muscle, 11-13 cm proximal to the active electrode recording. Superficial recording electrodes were placed on the fourth intermetacarpal space. The mean sensory conduction velocity (SCV in males was 63.7 -- 0.16 x age ± 3.36 m/s and in females was 57.7 ± 3.37 m/s. The mean sensory nerve action potential (SNAP amplitude in males was 19.5 ± 10.7 µV and in females was 24.6 ± 5.8 µV. The mean SNAP duration was 0.96 ± 0.13 ms. No significant differences regarding the DUC-SCV, distal latency, and SNAP duration or amplitude were found between both sides of the same subject. The amplitude of the SNAP was higher in females than males. The effects of age on DUC-SCV were distinct for each gender.

  5. [NMF and cosmetology of cutaneous hydration].

    Science.gov (United States)

    Marty, J-P

    2002-01-01

    In the stratum corneum, the water binds to the intracellular hygroscopic and hydrosoluble substances called "natural moisturizing factors" or NMF. These "natural moisturizing factors" contained in the corneocytes are formed during epidermal differentiation and may represent up to 10 p. cent of the corneocyte mass. They are principally amino acids, carboxylic pyrrolidone acid, lactic acid, urea, glucose and mineral ions. Keratinization plays an important part in the formation of NMF that exhibit strong osmotic potential attracting the water molecules. The binding of water to NMF is the static aspect of cutaneous hydration. The second, dynamic, aspect is related to the selective permeability of the stratum corneum and to its lipid barrier properties, the permeability of which depends on the integrity and nature of the inter-corneocyte lipids and their lamellar organization between the cells. In these conditions, hydration cosmetics rely on two concepts that can be isolated or associated: the supply of hydrophilic substances to the stratum corneum, capable of attracting and retaining water (moisturizer) or capable of restoring the barrier in order to restore normal water loss or of protecting it against aggression (occlusive).

  6. Comorbidity of Leishmania major with cutaneous sarcoidosis

    Directory of Open Access Journals (Sweden)

    Hamideh Moravvej

    2014-01-01

    Full Text Available Background: leishmaniasis infection might manifest as sarcoidosis; on the other hand, some evidences propose an association between sarcoidosis and leishmaniasis. Most of the times, it is impossible to discriminate idiopathic sarcoidosis from leishmaniasis by conventional histopathologic exam. Aim: We performed a cross-sectional study to examine the association of sarcoidosis with leishmaniasis in histopathologically diagnosed sarcoidal granuloma biopsy samples by polymerase chain reaction (PCR. Materials and Methods: We examined paraffin-embedded skin biopsy samples obtained from patients with clinical and histopathological diagnosis as naked sarcoidal granuloma, referred to Skin Research Center of Shaheed Beheshti Medical University from January 2001 to March 2010, in order to isolate Leishmania parasite. The samples were reassessed by an independent dermatopathologist. DNA extracted from all specimens was analyzed by the commercially available PCR kits (DNPTM Kit, CinnaGen, Tehran, Iran to detect endemic Leishmania species, namely leishmania major (L. major. Results: L. major was positive in PCR of Eight out of twenty-five examined samples. Conclusion: Cutaneous leishmaniasis may be misinterpreted as sarcoidosis; in endemic areas, when conventional methods fail to detect Leishmania parasite, PCR should be utilized in any granulomatous skin disease compatible with sarcoidosis, regardless of the clinical presentation or histopathological interpretation.

  7. Cutaneous leishmaniasis in North Africa: a review.

    Science.gov (United States)

    Aoun, Karim; Bouratbine, Aïda

    2014-01-01

    In North African countries, cutaneous leishmaniasis transmission has been increasing since the 1980s, with a significant increase in the incidence of cases and a spread of the geographical distribution. The disease currently represents a major public health problem with a productivity gap and an impediment for development, which results in dramatic socioeconomic and psycho-sanitary impacts. The incidence is more than thousands of cases every year in Algeria, Libya, Morocco, and Tunisia. In Egypt, only a few dozen cases per year are reported, mainly in the Sinai Peninsula. Three Leishmania species, associated with distinct eco-epidemiological and clinical patterns, are involved, namely Leishmania infantum, L. major, and L. tropica. However, L. major is by far the most frequent in Algeria, Libya, and Tunisia, with more than 90% of the registered cases. It is mainly encountered in rural areas under semi-arid, arid and Saharan climates. Leishmania tropica is more prevalent in Morocco, reaching 30-40% of isolates in some districts. Much data is still missing concerning the risk factors of the infection and the lesion development, as well as vector and reservoir ecology and behavior. The knowledge of such parameters, following multidisciplinary and integrated approaches, is crucial for better management and control of the disease, that also faces a lack of resources and efficient control measures. © K. Aoun & A. Bouratbine, published by EDP Sciences, 2014.

  8. Cutaneous Leishmaniasis in North Africa: a review

    Directory of Open Access Journals (Sweden)

    2014-01-01

    Full Text Available In North African countries, cutaneous leishmaniasis transmission has been increasing since the 1980s, with a significant increase in the incidence of cases and a spread of the geographical distribution. The disease currently represents a major public health problem with a productivity gap and an impediment for development, which results in dramatic socioeconomic and psycho-sanitary impacts. The incidence is more than thousands of cases every year in Algeria, Libya, Morocco, and Tunisia. In Egypt, only a few dozen cases per year are reported, mainly in the Sinai Peninsula. Three Leishmania species, associated with distinct eco-epidemiological and clinical patterns, are involved, namely Leishmania infantum, L. major, and L. tropica. However, L. major is by far the most frequent in Algeria, Libya, and Tunisia, with more than 90% of the registered cases. It is mainly encountered in rural areas under semi-arid, arid and Saharan climates. Leishmania tropica is more prevalent in Morocco, reaching 30–40% of isolates in some districts. Much data is still missing concerning the risk factors of the infection and the lesion development, as well as vector and reservoir ecology and behavior. The knowledge of such parameters, following multidisciplinary and integrated approaches, is crucial for better management and control of the disease, that also faces a lack of resources and efficient control measures.

  9. Predicting Geographic Variation in Cutaneous Leishmaniasis, Colombia

    Science.gov (United States)

    Campbell-Lendrum, Diarmid H.; Davies, Clive R.

    2004-01-01

    Approximately 6,000 cases of cutaneous leishmaniasis are reported annually in Colombia, a greater than twofold increase since the 1980s. Such reports certainly underestimate true incidence, and their geographic distribution is likely biased by local health service effectiveness. We investigated how well freely available environmental data explain the distribution of cases among 1,079 municipalities. For each municipality, a unique predictive logistic regression model was derived from the association among remaining municipalities between elevation, land cover (preclassified maps derived from satellite images), or both, and the odds of at least one case being reported. Land cover had greater predictive power than elevation; using both datasets improved accuracy. Fitting separate models to different ecologic zones, reflecting transmission cycle diversity, enhanced the accuracy of predictions. We derived measures that can be directly related to disease control decisions and show how results can vary, depending on the threshold selected for predicting a disease-positive municipality. The results identify areas where disease is most likely to be underreported. PMID:15200848

  10. Polymyxin B-Induced Diffuse Cutaneous Hyperpigmentation.

    Science.gov (United States)

    Lahiry, Sandeep; Choudhury, Shouvik; Mukherjee, Ayan; Bhunya, Prajesh Kiran; Bala, Moumita

    2017-02-01

    Polymyxin B is a polypeptide-antibiotic, primarily used for resistant Gram-negative infections, first obtained from bacterium Bacillus polymyxa in the late 1940s. Antibiotic spectrum are restricted to mainly gram negative bacterias like Enterobacter, E. coli, Klebsiella, Salmonella, Pasteurella, Bordetella, Shigella; and particularly organisms like Pseudomonas aeruginosa and Acinetobacter baumannii, which are extremely potent to acquire antibiotic resistance. Side effects include neurotoxicity and acute renal tubular necrosis. Here, we present a rare case of skin hyper-pigmentation in a 65-year-old elderly male of Indian origin, diagnosed as a case of Multi-Drug Resistant (MDR) Klebsiella pneumonia, treated with intravenous antibiotics. The manifestations were observed after 4 days of Polymyxin B therapy initiation. All other concomitant drugs, infections, or immunologic disorders that, could have caused this symptom, were carefully excluded. An objective causality assessment reveals that, the cutaneous hyperpigmentation was possibly associated with Polymyxin B therapy, though further studies may be needed to explain the underlying mechanism.

  11. Self-healing juvenile cutaneous mucinosis.

    Science.gov (United States)

    Kołodziejczyk, Beata; Gazda, Agnieszka; Hernik, Elżbieta; Szczygielska, Izabela; Rutkowska-Sak, Lidia; Koprowska, Marta Legatowicz

    2017-01-01

    Girl, aged 4 years old, began the disease with pain of the lower extremities, fever up to 38°C and signs of upper airway infection. Then the patient developed oedema and redness of the whole face, thickened skin, subcutaneous nodular foldings of the frontal, occipital, cervical and axillary regions, extensor areas of the joints; fine, hard whitish nodules in the frontal region and over interphalangeal joints of the hands, pruritus; oedemas of the ankles, knees and joints of the hands, cervical lymphadenopathy and hepatomegaly. Blood tests at the moment of the diagnosis revealed elevation of markers of inflammation as ESR and CRP, leukocytosis, thrombocytosis, hypoalbuminemia, and hyper-alfa-2-globulinemia. Histopathological examination of the skin biopsy specimen and subcutaneous tissue revealed myxoid subcutaneous tissue located under the dermis and a section consisting of myxoid mesenchymal tissue with inflammatory infiltration by histiocytic cells. The presence of acid mucopolysaccharides in fields of the myxoid tissue was also observed. The self-healing juvenile cutaneous mucinosis (SJCM) was diagnosed.

  12. Selenium for the prevention of cutaneous melanoma.

    Science.gov (United States)

    Cassidy, Pamela B; Fain, Heidi D; Cassidy, James P; Tran, Sally M; Moos, Philip J; Boucher, Kenneth M; Gerads, Russell; Florell, Scott R; Grossman, Douglas; Leachman, Sancy A

    2013-03-07

    The role of selenium (Se) supplementation in cancer prevention is controversial; effects often depend on the nutritional status of the subject and on the chemical form in which Se is provided. We used a combination of in vitro and in vivo models to study two unique therapeutic windows for intervention in the process of cutaneous melanomagenisis, and to examine the utility of two different chemical forms of Se for prevention and treatment of melanoma. We studied the effects of Se in vitro on UV-induced oxidative stress in melanocytes, and on apoptosis and cell cycle progression in melanoma cells. In vivo, we used the HGF transgenic mouse model of UV-induced melanoma to demonstrate that topical treatment with l-selenomethionine results in a significant delay in the time required for UV-induced melanoma development, but also increases the rate of growth of those tumors once they appear. In a second mouse model, we found that oral administration of high dose methylseleninic acid significantly decreases the size of human melanoma xenografts. Our findings suggest that modestly elevation of selenium levels in the skin might risk acceleration of growth of incipient tumors. Additionally, certain Se compounds administered at very high doses could have utility for the treatment of fully-malignant tumors or prevention of recurrence.

  13. Selenium for the Prevention of Cutaneous Melanoma

    Directory of Open Access Journals (Sweden)

    Douglas Grossman

    2013-03-01

    Full Text Available The role of selenium (Se supplementation in cancer prevention is controversial; effects often depend on the nutritional status of the subject and on the chemical form in which Se is provided. We used a combination of in vitro and in vivo models to study two unique therapeutic windows for intervention in the process of cutaneous melanomagenisis, and to examine the utility of two different chemical forms of Se for prevention and treatment of melanoma. We studied the effects of Se in vitro on UV-induced oxidative stress in melanocytes, and on apoptosis and cell cycle progression in melanoma cells. In vivo, we used the HGF transgenic mouse model of UV-induced melanoma to demonstrate that topical treatment with l-selenomethionine results in a significant delay in the time required for UV-induced melanoma development, but also increases the rate of growth of those tumors once they appear. In a second mouse model, we found that oral administration of high dose methylseleninic acid significantly decreases the size of human melanoma xenografts. Our findings suggest that modestly elevation of selenium levels in the skin might risk acceleration of growth of incipient tumors. Additionally, certain Se compounds administered at very high doses could have utility for the treatment of fully-malignant tumors or prevention of recurrence.

  14. Cutaneous cylindroma: it's all about MYB.

    Science.gov (United States)

    Corda, Gabriele; Sala, Arturo

    2016-08-01

    Cutaneous cylindroma is a rare benign tumour that occasionally turns into malignant cylindrocarcinoma. The cancer can be sporadic or emerge in the context of Brooke-Spiegler syndrome (BSS), an inheritable condition characterized by mutation of the gene CYLD, encoding a tumour suppressor protein that controls the activity of the transcription factor NF-kB. Sporadic cylindromas present histological features shared with adenoid cystic carcinoma (ACC), a head and neck cancer originating from salivary or other exocrine glands. Like ACCs, sporadic cylindromas express, although at lower frequency, the aberrant fusion transcript MYB-NFIB. In a paper recently published in the Journal of Pathology, the research teams led by Neil Rajan and Goran Stenman demonstrate that CYLD-defective cyclindromas in BSS patients are negative for the MYB-NFIB fusion. Only the wild-type MYB oncoprotein is activated in the majority of these tumours. RNA interference studies in cells derived from BSS patients indicate that ablating MYB expression results in a striking reduction of cylindroma cell proliferation, suggesting that MYB plays a pivotal role in the biology of this cancer. The take-home message of the study is that activation of MYB, in its wild-type form or fusion derivatives, is a common feature of spontaneous and hereditary cylindromas, constituting a potentially actionable therapeutic target. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

  15. Cutaneous reactions due to antihypertensive drugs

    Directory of Open Access Journals (Sweden)

    Upadhayai J

    2006-01-01

    Full Text Available Out of a total of 1147 patients on antihypertensive drugs, 23 (2.04% developed adverse cutaneous drug reactions (ACDR. The commonest antihypertensive drug group causing ACDR was beta-blockers of which atenolol was the commonest culprit. The second most common group was calcium channel blockers with amlodipine as the commonest offender. The most common patterns of ACDR observed included urticaria followed by lichenoid drug eruption (LDE. We noted 2 new patterns of reactions; (i one patient developed brownish blue pigmentation of nails while on atenolol for 3 years, which resolved in 4 months after withdrawal and (ii another patient on amlodipine for 8 years developed Schamberg′s like purpuric pigmentation, which resolved on withdrawal of drug within 3 months. These findings have not been reported in the literature earlier. This study is presented for paucity of Indian data on ACDR due to antihypertensive drugs, and remarkable advancement in area of cardiovascular and antihypertensive pharmacology and a large number of population taking antihypertensive drugs.

  16. [Systemic lupus erythematosus : Unusual cutaneous manifestations].

    Science.gov (United States)

    Stockinger, T; Richter, L; Kanzler, M; Melichart-Kotik, M; Pas, H; Derfler, K; Schmidt, E; Rappersberger, K

    2016-12-01

    Various different mucocutaneous symptoms may affect up to 80 % of systemic lupus erythematosus (SLE) patients. To investigate, various unspecific, but otherwise typical clinical symptoms of skin and mucous membranes that arise in SLE patients other than those defined as SLE criteria such as butterfly rash, chronic cutaneous lupus erythematosus, oral ulcers, and increased photosensitivity. Extensive search of peer-reviewed scientific articles was performed, medical histories of several SLE patients seen in our department were analyzed, and the rare disease courses in three SLE patients are presented. Here we present a variety of unspecific but typical mucocutaneous manifestations in SLE patients: periungual erythema, periungual telangiectasia and periungual splinter hemorrhage, papules on the dorsum of the hands, scaling erythema, sometimes associated with necrosis, especially of the ears, along with complement deficiency, and the bizarre necroses of antiphospholipid syndrome. Furthermore, we show the typical clinico-histological features of neutrophilic urticarial dermatosis, as well as those of bullous SLE and finally a severe course of bacterial sepsis with Neisseria flavescens/macacae. Here we show several unspecific but rather typical mucocutaneous symptoms in lupus patients that are indicative of SLE and thus may lead to an early diagnosis. Also, life-threatening bacterial sepsis may occur with microorganisms that are commonly considered "apathogenic", such as Neisseria flavescens/macacae, which exclusively affect immunosuppressed patients.

  17. Cutaneous silent period in myofascial pain syndrome.

    Science.gov (United States)

    Kilinc, Ozden; Sencan, Savas; Ercalik, Tulay; Koytak, Pinar Kahraman; Alibas, Hande; Gunduz, Osman Hakan; Tanridag, Tulin; Uluc, Kayihan

    2018-01-01

    An increased response to painful stimuli without spontaneous pain suggests a role of central hyperexcitability of pain pathways in the pathogenesis of myofascial pain syndrome (MPS). In this study we aimed to test the hypothesis that spinal pain pathways are affected in MPS. We used cutaneous silent period (CSP) parameters to demonstrate the hyperexcitability of spinal pain pathways in MPS. Twenty-nine patients diagnosed with MPS and 30 healthy volunteers were included in the study. The CSP recordings were performed in the right upper and left lower extremities. In both upper and lower extremities, patients had prolonged CSP latencies (P = 0.034 and P = 0.049 respectively) and shortened CSP durations (P = 0.009 and P = 0.008, respectively). Delayed and shortened CSP in MPS patients implies dysfunction in the inhibitory mechanism of the spinal/supraspinal pain pathways, suggesting central sensitization in the pathogenesis of MPS and supporting our research hypothesis. Muscle Nerve 57: E24-E28, 2018. © 2017 Wiley Periodicals, Inc.

  18. Comparative study of anchoring groups for molecular electronics: structure and conductance of Au-S-Au and Au-NH{sub 2}-Au junctions

    Energy Technology Data Exchange (ETDEWEB)

    Kristensen, I S; Mowbray, D J; Thygesen, K S; Jacobsen, K W [Center for Atomic-scale Materials Design (CAMD), Department of Physics, Building 307, Technical University of Denmark, DK-2800 Kongens Lyngby (Denmark)

    2008-09-17

    The electrical properties of single-molecule junctions, consisting of an organic molecule coupled to metal electrodes, are sensitive to the detailed atomic structure of the molecule-metal contact. This, in turn, is determined by the anchoring group linking the molecule to the metal. With the aim of identifying and comparing the intrinsic properties of two commonly used anchoring groups, namely thiol and amine groups, we have calculated the atomic structure and conductance traces of different Au-S-Au and Au-NH{sub 2}-Au nanojunctions using density functional theory (DFT). Whereas NH{sub 2} shows a strong structural selectivity towards atop-gold configurations, S shows large variability in its bonding geometries. As a result, the conductance of the Au-NH{sub 2}-Au junction is less sensitive to the structure of the gold contacts than the Au-S-Au junction. These findings support recent experiments which show that amine-bonded molecules exhibit more well-defined conductance properties than do thiol-bonded molecules.

  19. Travailler avec Windows 7 au CERN (FR)

    CERN Multimedia

    CERN. Geneva

    2010-01-01

    Vue d'ensemble des nouveaux concepts et des changements dans l'interface utilisateur survenus dans Windows 7 depuis les versions antérieures de Windows (XP ou Vista). La mise à disposition de Windows 7 au CERN et son intégration dans l’infrastructure de Windows au CERN seront présentées.

  20. Evaluation d'un scenario d'apprentissage favorisant la mobilisation des habiletes reliees au processus d'enquete

    Science.gov (United States)

    Blanchard, Samuel F. J.

    Les resultats au Programme international pour le suivi des acquis des eleves (PISA) demontrent que les jeunes neobrunswickois francophones se classent b un niveau significativement inferieur comparaiivement aux eleves anglophones du Nouveau-Brunswick, aux eleves des autres provinces canadiennes et se classent sous la moyenne internationale de tous les pays participants quant b la culture scientifique. L'evaluation de cette culture scientifique est basee sur une serie de savoirs, de savoir-faire et de savoir-etre reliee au processus d'enquete scolaire. Le processus d'enquete scolaire est une approche b l'apprentissage ou les eleves effectuent des recherches d'informations, discutent d'idees et entreprennent des investigations pour augmenter leur comprehension d'un probleme ou d'un sujet. Les recherches demontrent que le processus d'enquete scolaire est rarement une composante pedagogique importante de la salle de classe et les recherches portant sur l'implantation du processus d'enquete scolaire recommandent de rendre ce dernier plus accessible aux enseignantes et aux enseignants. Afin de rendre le processus d'enquete plus accessible aux enseignantes et aux enseignants, notre recherche porte sur l'evaluation de la valeur pedagogique d'un scenario d'apprentissage (PhaRoboS) concu specialement pour creer un environnement dans lequel les eleves auront plusieurs occasions a mobiliser les habiletes reliees au processus d'enquete. Les retombees de cette evaluation nous permettront d'offrir des pistes de remediations afin d'aider plus d'enseignantes et d'enseignants b creer un environnement dans lequel les eleves auront plusieurs occasions b mobiliser les habiletes reliees au processus d'enquete. Cette evaluation s'est faite a partir d'une methodologie inspiree de l'evaluation pour fin d'amelioration d'un objet pedagogique. L'analyse des donnees qualitatives recueillies aupres des eleves et de leur enseignante d'une ecole francophone du Nouveau-Brunswick semble montrer que

  1. English for au pairs the au pair's guide to learning English

    CERN Document Server

    Curtis, Lucy

    2014-01-01

    English for Au Pairs has interlinked stories about a group of au pairs new to England. Marta, an 18-year-old from Poland arrives in the UK to work as an au pair. Throughout her year-long stay she has many different experiences - some bad, some good - but with the support of her host family she finds new friends and improves her English. English for Au Pairs offers insight into the joys and difficulties of being an au pair while at the same time reinforcing English language learning through grammar explanations and exercises.

  2. Au microstructure and the functional properties of Ni/Au finishes on ceramic IC packages

    Energy Technology Data Exchange (ETDEWEB)

    Winters, E.D.; Baxter, W.K. [Coors Electronic Package Co., Chattanooga, TN (United States); Braski, D.N.; Watkins, T.R. [Oak Ridge National Lab., TN (United States)

    1995-12-31

    Ni/Au plated finishes used on thick-film metallized multilayer ceramic packages for integrated circuits must meet functional requirements such as bondability, sealability, and solderability. Their ability to do so is dependent, among other things, on the ability of the Au deposit to inhibit the grain boundary diffusion and subsequent surface oxidation of Ni. In this study, the relation between functional performance, Ni diffusionr ate, and Au microstructure was examined. Extent of Ni diffusion during heating was determined by Auger electron spectroscopy for several electrolytic and electroless Ni/Au finishing processes. Results were correlated with differences in Au microstructures determined by SEM, atomic force microscopy, and XRD.

  3. AU-EU “Strategic Partnership”

    DEFF Research Database (Denmark)

    Rodt, Annemarie Peen; Okeke, Jide

    2013-01-01

    This article appraises strategic partnership between the African Union (AU) and European Union (EU). It examines the context and nature of AU and EU security relations and explores the conditions under which partnership has a positive impact in this regard. This includes an evaluation of converge......This article appraises strategic partnership between the African Union (AU) and European Union (EU). It examines the context and nature of AU and EU security relations and explores the conditions under which partnership has a positive impact in this regard. This includes an evaluation...... of convergence between the two organizations and its effect or lack thereof on African security. The article concludes that events leading up to and initiatives following the 2007 Joint Africa–European Union Strategy have produced a degree of AU and EU convergence, which has had limited impact on the efficacy...

  4. Structure of the thiolated Au130 cluster.

    Science.gov (United States)

    Tlahuice-Flores, Alfredo; Santiago, Ulises; Bahena, Daniel; Vinogradova, Ekaterina; Conroy, Cecil V; Ahuja, Tarushee; Bach, Stephan B H; Ponce, Arturo; Wang, Gangli; José-Yacamán, Miguel; Whetten, Robert L

    2013-10-10

    The structure of the recently discovered Au130-thiolate and -dithiolate clusters is explored in a combined experiment-theory approach. Rapid electron diffraction in scanning/transmission electron microscopy (STEM) enables atomic-resolution imaging of the gold core and the comparison with density functional theory (DFT)-optimized realistic structure models. The results are consistent with a 105-atom truncated-decahedral core protected by 25 short staple motifs, incorporating disulfide bridges linking the dithiolate ligands. The optimized structure also accounts, via time-dependent DFT (TD-DFT) simulation, for the distinctive optical absorption spectrum, and rationalizes the special stability underlying the selective formation of the Au130 cluster in high yield. The structure is distinct from, yet shares some features with, each of the known Au102 and Au144/Au146 systems.

  5. Gas-phase experiments on Au(III) photochemistry.

    Science.gov (United States)

    Marcum, Jesse C; Kaufman, Sydney H; Weber, J Mathias

    2011-04-14

    Irradiation of AuCl(4)(-) and AuCl(2)(OH)(2)(-) in the gas-phase using ultraviolet light (220-415 nm) leads to their dissociation. Observed fragment ions for AuCl(4)(-) are AuCl(3)(-) and AuCl(2)(-) and for AuCl(2)(OH)(2)(-) are AuCl(2)(-) and AuClOH(-). All fragment channels correspond to photoreduction of the gold atom to either Au(II) or Au(I) depending on the number of neutral ligands lost. Fragment branching ratios of AuCl(4)(-) are observed to be highly energy dependent and can be explained by comparison of the experimental data to calculated threshold energies obtained using density functional theory. The main observed spectral features are attributed to ligand-to-metal charge transfer transitions. These results are discussed in the context of the molecular-level mechanisms of Au(III) photochemistry.

  6. Magnetic depth profiling of Fe/Au multilayer using neutron ...

    Indian Academy of Sciences (India)

    Au multilayer sample for characterizing the layer structure and magnetic moment density profile. Fe/Au multilayer shows strong spin-dependent scattering at interfaces, making it a prospective GMR material. Fe/Au multilayer with bilayer ...

  7. Introduction au numéro

    Directory of Open Access Journals (Sweden)

    François L’Italien

    2011-11-01

    Full Text Available Ce dossier de la revue Interventions économiques a pour objectif de présenter des voies de renouveau de l'analyse des industries. Délaissé depuis plusieurs années, ce niveau d’analyse revient en force et montre ici toute son utilité, aussi bien sur le plan de la construction des politiques de développement économique que de la formation de chercheurs sur l'économie du Québec. Des travaux hétérodoxes d'inspiration institutionnaliste ou encore des approches critiques du management ont mis en év...

  8. Multiple café au lait spots in familial patients with MAP2K2 mutation.

    Science.gov (United States)

    Takenouchi, Toshiki; Shimizu, Atsushi; Torii, Chiharu; Kosaki, Rika; Takahashi, Takao; Saya, Hideyuki; Kosaki, Kenjiro

    2014-02-01

    Recent advances in genetic diagnostic technologies have made the classic disease nosology highly complicated. This situation is exemplified by rasopathies, among which neurofibromatosis type 1 and Noonan syndrome represent prototypic entities. The former condition is characterized by multiple café au lait spots and neurofibromas, while the latter is characterized by distinct facial features, webbed neck, congenital heart disease, and a short stature. On rare occasions, the features of both neurofibromatosis and Noonan syndrome co-exist within an individual; such patients are diagnosed as having neurofibromatosis-Noonan syndrome. Here, we report familial patients with multiple café au lait spots and Noonan syndrome-like facial features. A mutation analysis unexpectedly revealed a mutation in MAP2K2 in both the propositus and his mother. The propositus fulfilled the diagnostic criteria for neurofibromatosis type 1, but his mother did not. Their phenotype was not consistent with that of cardio-facio-cutaneous syndrome, which is classically known to be associated with MAP2K2 mutations. The mother of the propositus had cervical cancer at the age of 23 years, consistent with the oncogenic tendency associated with rasopathies. The phenotypic combination of multiple café au lait spots and Noonan syndrome-like facial features suggested a diagnosis of neurofibromatosis-Noonan syndrome. Whether this condition represents a discrete disease entity or a variable expression of neurofibromatosis type 1 has long been debated. The present observation suggests that some perturbation in the RAS/MAPK signaling cascade results in multiple café au lait spots, a key diagnostic phenotype of rasopathies, although the exact mechanism remains to be elucidated. © 2013 Wiley Periodicals, Inc.

  9. Cutaneous Conditions Leading to Dermatology Consultations in the Emergency Department

    Directory of Open Access Journals (Sweden)

    David H Peng

    2011-05-01

    Full Text Available Introduction: We established the most common cutaneous diseases that received dermatology consultation in the adult emergency department (ED and identified differentiating clinical characteristics of dermatoses that required hospital admission. Methods: A retrospective chart review of 204 patients presenting to the ED who received dermatology consultations at Los Angeles County/University of Southern California Medical Center, an urban tertiary care teaching hospital. Results: Of all patients, 18% were admitted to an inpatient unit primarily for their cutaneous disease, whereas 82% were not. Of nonadmitted patients, the most commonly diagnosed conditions were eczematous dermatitis not otherwise specified (8.9%, scabies (7.2%, contact dermatitis (6.6%, cutaneous drug eruption (6.0%, psoriasis vulgaris (4.2%, and basal cell carcinoma (3.6%. Of patients admitted for their dermatoses, the most highly prevalent conditions were erythema multiforme major/Stevens-Johnson syndrome (22%, pemphigus vulgaris (14%, and severe cutaneous drug eruption (11%. When compared with those of nonadmitted patients, admitted skin conditions were more likely to be generalized (92% vs 72%; P = 0.0104, acute in onset ( Conclusion: We have described a cohort of patients receiving dermatologic consultation in the ED of a large urban teaching hospital. These data identify high-risk features of more severe skin disease and may be used to refine curricula in both emergency and nonemergency cutaneous disorders for emergency physicians. [West J Emerg Med. 2011;12(4:551–555.

  10. Cutaneous tuberculosis after mesotherapy: report of six cases.

    Science.gov (United States)

    Orjuela, Dora; Puerto, Gloria; Mejía, Graciela; Castro, Claudia; Garzón, María Consuelo; García, Luz Mary; Hernández, Elkin; Ribón, Wellman; Rodríguez, Gerzaín

    2010-01-01

    Cutaneous tuberculosis as a result of a needle injection is a rare event; it generally occurs among medical and laboratory personnel and among patients receiving percutaneous treatment. Six patients are presented who developed cutaneous tuberculosis after mesotherapy cosmetic treatment. One to four months after injection of an unknown product as treatment for obesity and cellulites, five women and a man developed papules, nodules and drainage of wax like material at the inoculated sites; this was interpreted clinically as a non tuberculous mycobacterium infection. Skin biopsies were taken for a histopathologic study; the biopsy and exudates were cultured to make a phenotypic identification. Polymerase chain reaction and restriction enzyme pattern analyses (PCR-restriction pattern analysis)) procedures were applied to the skin biopsies. Mycobacterium tuberculosis was confirmed in the culture and by PRA analysis in the paraffin-embedded biopsies. The patients had never had tuberculosis. Their thoracic X rays were normal and the size of the tuberculin reaction was 17 to 20 mm. Five patients recovered with antituberculosis treatment and the sixth spontaneously healed after the removal of the largest cutaneous module. No satellite adenopathy or recurrences were observed. A previously undescribed mode of acquisition cutaneous tuberculosis was described. This was the second incident of a demonstrated cutaneous tuberculosis following mesotherapy in Colombia. Skin lesions induced by injections must be tested to detect mycobacterias to include M. tuberculosis.

  11. Imaging of cutaneous larva migrans by optical coherence tomography.

    Science.gov (United States)

    Morsy, Hanan; Mogensen, Mette; Thomsen, Jakob; Thrane, Lars; Andersen, Peter E; Jemec, Gregor B E

    2007-07-01

    Cutaneous larva migrans is a parasitic skin eruption caused by migration of larvae of various nematodes. Diagnosis of cutaneous larva migrans is currently based on the clinical signs of the creeping eruption. We are investigating a new diagnostic technology called optical coherence tomography (OCT) , which is potentially able to visualize structures in the skin with an 8 microm resolution. This technology could therefore potentially allow rapid, non-invasive, in vivo diagnosis of infestations. Clinical cases of cutaneous larva migrans (n=3) were studied. All patients had a characteristic itching, serpinginous eruption typical of cutaneous larva migrans. The parasites were acquired on beach holidays in Thailand and Malaysia. All skin lesions were imaged by an OCT system developed at Risoe National Laboratory, Denmark. Two out of three patients showed a round to oval structure (diameter 0.3-0.5mm) in the epidermis, Thus distinct OCT morphology in skin areas affected by cutaneous larva migrans was demonstrated. The larvae were not visualized in any of the patients. This study demonstrates that OCT a novel optical imaging technology, can image the larva tunnel in the skin with adequate spatial resolution, but not the larvae itself. OCT has a potential in imaging of skin infestations.

  12. Prediction Feasibility of Cutaneous Leishmaniasis Using Climatic Variables in Poldokhtar

    Directory of Open Access Journals (Sweden)

    Behroz Parvaneh

    2017-03-01

    Full Text Available Background: The increasing number of patients suffering from cutaneous leishmaniasis in Poldokhtar County during the last 10 years and technological advances in data generation has increased the necessity to produce the predicting models of disease prevalence in the region. Therefore, climatic variables were used in this study to predict the cutaneous leishmaniasis. Materials and Methods: In this study using regression model, the relationship between number of patients with cutaneous leishmaniasis and climatic signals were taken simultaneously and with one, two, three and four months of regression lag. Results: Totally there was a significant relationship between January patients with January NINO1 climatic signal, March patients with February PNA climatic signal, April patients with March AAMM climatic signal, May patients with April AO climatic signal, and August patients with June TSA climatic signal, at 5% significance level. Furthermore, there was a significant relationship between February patients with January NINO1 climatic signal, at 10% significance level. Conclusion: This investigation showed that use of climatic signals with lags for predicting the disease was better than simultaneous application of signals and disease. Correlation between statistics relating to diseases during the entire period and PDO signal with 2 months of lag was obtained as 84.53. In addition, results indicated that approximately during half of the months in a year, there was a good correlation between prevalence of cutaneous leishmaniasis and the climatic signals and thus enabling us to discover prevalence of cutaneous leishmaniasis using the climatic signals.

  13. The Role of Iron in the Skin & Cutaneous Wound Healing

    Directory of Open Access Journals (Sweden)

    Josephine Anne Wright

    2014-07-01

    Full Text Available In this review article we discuss current knowledge about iron in the skin and the cutaneous wound healing process. Iron plays a key role in both oxidative stress and photo-induced skin damage. The main causes of oxidative stress in the skin include reactive oxygen species (ROS generated in the skin by ultraviolet (UVA 320-400 nm portion of the ultraviolet spectrum and biologically available iron. We also discuss the relationships between iron deficiency, anaemia and cutaneous wound healing. Studies looking at this fall into two distinct groups. Early studies investigated the effect of anaemia on wound healing using a variety of experimental methodology to establish anaemia or iron deficiency and focused on wound-strength rather than effect on macroscopic healing or re-epithelialisation. More recent animal studies have investigated novel treatments aimed at correcting the effects of systemic iron deficiency and localised iron overload. Iron overload is associated with local cutaneous iron deposition, which has numerous deleterious effects in chronic venous disease and hereditary haemochromatosis. Iron plays a key role in chronic ulceration and conditions such as Rheumatoid Arthritis (RA and Lupus Erythematosus are associated with both anaemia of chronic disease and dysregulation of local cutaneous iron haemostasis. Iron is a potential therapeutic target in the skin by application of topical iron chelators and novel pharmacological agents, and in delayed cutaneous wound healing by treatment of iron deficiency or underlying systemic inflammation.

  14. Clinical and dermoscopic evaluation of cutaneous leishmaniasis.

    Science.gov (United States)

    Ayhan, Erhan; Ucmak, Derya; Baykara, Sule Nergiz; Akkurt, Zeynep Meltem; Arica, Mustafa

    2015-02-01

    Dermoscopy is a method to aid in the visualization of the epidermis and dermis. In recent years, the use of dermoscopy in the diagnosis of non-melanocytic lesions such as those of leishmania cutis has increased. This study was intended to establish whether dermoscopic investigation has any diagnostic value in cutaneous leishmaniasis (CL). Fifty-five patients diagnosed with CL at the Department of Dermatology, Faculty of Medicine, Dicle University, between February and October 2012, were included in the study. Collectively, the patients exhibited a total of 127 lesions. The mean ± standard deviation age of the patients was 25.7 ± 21.3 years (range: 4-86 years). Twenty-three (41.8%) patients were male, and 32 (58.2%) were female. In dermoscopy, teardrop-like structures were observed in 42.5% of the lesions. Vascular structures were detected in 115 (90.6%) lesions; no vascular structures were observed in 12 (9.4%) lesions. Branching, linear, comma-like, and polymorphic vessels were seen more commonly in lesions on the face; pin-point and hairpin-like vessels were seen more commonly in lesions on the upper extremities. When the findings obtained in this study were evaluated along with those reported in the literature, it became apparent that follicular plugs, also called "teardrop-like structures", seen on the face and neck may be a dermoscopic feature specific to CL. As hairpin-like vessels seen in an asymmetric radial arrangement were often observed on parts of the body other than the face, further dermoscopic studies comparing the lesions of CL with other ulcerating lesions are necessary. © 2014 The International Society of Dermatology.

  15. Interventions for Old World cutaneous leishmaniasis.

    Science.gov (United States)

    Heras-Mosteiro, Julio; Monge-Maillo, Begoña; Pinart, Mariona; Lopez Pereira, Patricia; Reveiz, Ludovic; Garcia-Carrasco, Emely; Campuzano Cuadrado, Pedro; Royuela, Ana; Mendez Roman, Irene; López-Vélez, Rogelio

    2017-12-01

    Cutaneous leishmaniasis, caused by a parasitic infection, is considered one of the most serious skin diseases in many low- and middle-income countries. Old World cutaneous leishmaniasis (OWCL) is caused by species found in Africa, Asia, the Middle East, the Mediterranean, and India. The most commonly prescribed treatments are antimonials, but other drugs have been used with varying success. As OWCL tends to heal spontaneously, it is necessary to justify the use of systemic and topical treatments. This is an update of a Cochrane Review first published in 2008. To assess the effects of therapeutic interventions for the localised form of Old World cutaneous leishmaniasis. We updated our searches of the following databases to November 2016: the Cochrane Skin Specialised Register, CENTRAL, MEDLINE, Embase, and LILACS. We also searched five trials registers and checked the reference lists of included studies for further references to relevant randomised controlled trials (RCTs). We wrote to national programme managers, general co-ordinators, directors, clinicians, WHO-EMRO regional officers of endemic countries, pharmaceutical companies, tropical medicine centres, and authors of relevant papers for further information about relevant unpublished and ongoing trials. We undertook a separate search for adverse effects of interventions for Old World cutaneous leishmaniasis in September 2015 using MEDLINE. Randomised controlled trials of either single or combination treatments in immunocompetent people with OWCL confirmed by smear, histology, culture, or polymerase chain reaction. The comparators were either no treatment, placebo/vehicle, and/or another active compound. Two review authors independently assessed trials for inclusion and risk of bias and extracted data. We only synthesised data when we were able to identify at least two studies investigating similar treatments and reporting data amenable to pooling. We also recorded data about adverse effects from the

  16. INFRARED THERMOGRAPHY OF CUTANEOUS MELANOMA METASTASES

    Science.gov (United States)

    Shada, Amber L.; Dengel, Lynn T.; Petroni, Gina R.; Smolkin, Mark E.; Acton, Scott; Slingluff, Craig L.

    2014-01-01

    Background Differentiating melanoma metastasis from benign cutaneous lesions currently requires biopsy or costly imaging, such as positron emission tomography scans. Melanoma metastases have been observed to be subjectively warmer than similarly appearing benign lesions. We hypothesized that infrared (IR) thermography would be sensitive and specific in differentiating palpable melanoma metastases from benign lesions. Materials and methods Seventy-four patients (36 females and 38 males) had 251 palpable lesions imaged for this pilot study. Diagnosis was determined using pathologic confirmation or clinical diagnosis. Lesions were divided into size strata for analysis: 0–5, >5–15, >15–30, and >30 mm. Images were scored on a scale from −1 (colder than the surrounding tissue) to +3 (significantly hotter than the surrounding tissue). Sensitivity and specificity were calculated for each stratum. Logistical challenges were scored. Results IR imaging was able to determine the malignancy of small (0–5 mm) lesions with a sensitivity of 39% and specificity of 100%. For lesions >5–15 mm, sensitivity was 58% and specificity 98%. For lesions >15–30 mm, sensitivity was 95% and specificity 100%, and for lesions >30 mm, sensitivity was 78% and specificity 89%. The positive predictive value was 88%–100% across all strata, and the negative predictive value was 95% for >15–30 mm lesions and 80% for >30 mm lesions. Conclusions Malignant lesions >15 mm were differentiated from benign lesions with excellent sensitivity and specificity. IR imaging was well tolerated and feasible in a clinic setting. This pilot study shows promise in the use of thermography for the diagnosis of malignant melanoma with further potential as a noninvasive tool to follow tumor responses to systemic therapies. PMID:23043862

  17. Extensive cutaneous metastases of ovarian cancer after prolonged response to liposomal doxorubicin

    OpenAIRE

    Craig, Christine D.; Iglesias, David A.; Watkins, Jack; Coleman, Robert L.; Kilgore, Larry; Ramirez, Pedro T.

    2013-01-01

    Highlights ? Cutaneous metastases are rare and clinically challenging to manage. When present, they often represent end-stage disease. ? Treatments for cutaneous metastases are limited, and primarily palliative in nature.

  18. Extensive cutaneous metastases of ovarian cancer after prolonged response to liposomal doxorubicin.

    Science.gov (United States)

    Craig, Christine D; Iglesias, David A; Watkins, Jack; Coleman, Robert L; Kilgore, Larry; Ramirez, Pedro T

    2013-01-01

    Cutaneous metastases are rare and clinically challenging to manage. When present, they often represent end-stage disease.•Treatments for cutaneous metastases are limited, and primarily palliative in nature.

  19. L’usage politique de l’islam : l’universel au service d’un État. Le cas du Maroc The Political Use of Islam. The Universal in the Service of a State. The Moroccan Case

    Directory of Open Access Journals (Sweden)

    Abdessamad Belhaj

    2011-03-01

    Full Text Available Lorsqu’il s’agit d’étudier les rapports des pays arabes à la mondialisation, il est nécessaire d’évoquer l’islam. En tant que facteur local, la symbolique islamique offre des ressources de légitimation au pouvoir. Le cas marocain illustre bien la manière dont les rapports existant entre le Makhzen et le répertoire religieux (Amīr al-Mu’minīne, la bayca , la chérifibilité…  font de l’introduction de la modernité un simple espace virtuel et fonctionnel. L’émergence de la contestation islamiste participe à la consécration du répertoire traditionnel. D’autre part, depuis les trois dernières décennies, l’essor de l’islam mondialisé offre au Maroc des opportunités politiques à l’échelle mondiale. Ceci est observable au niveau du rôle joué par le pays dans le cadre de la diplomatie islamique (OCI, ISESCO…  ou au niveau de son positionnement dans l’islam européen. La gestion de l’interaction entre l’islam local et l’islam global, adaptée à la conjoncture internationale, assure le maintien au pouvoir du régime.One cannot study the relationships between Arab countries and globalization without taking Islam into account for it offers symbolic support to legitimizing local power. Morocco is a good example : the relations between the royal court (Makhzen and Islamic features such as being the Commander of the Faithful or Sheriffhood make of modernity a mere virtual or functional sphere. Even the emergence of Islamic contestation contributes to the consecration of the traditional repertory. On the other hand, the rise of world Islam during the last thirty years has opened up political opportunities for Morocco on the international stage – for instance the agencies of Islamic diplomacy (OCI, ISESCO or the quest for a new role in European Islam. By managing the interaction between the local and the global, the regime is able to keep itself in power.

  20. Au dissolution during the anodic response of short-chain alkylthiols with polycrystalline Au electrodes

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Scott R. [Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario P3E 2C6 (Canada); Guerra, Eduard [School of Engineering, Laurentian University, Sudbury, Ontario P3E 2C6 (Canada); Siemann, Stefan [Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario P3E 2C6 (Canada); Shepherd, Jeffrey L., E-mail: jshepherd@laurentian.ca [Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario P3E 2C6 (Canada)

    2011-10-01

    Highlights: > 3-Mercaptopropionic acid (MPA) or meso-2,3-dimercaptosuccinic acid (DMSA) mediated Au corrosion in aqueous electrolytes at anodic potentials. > Au is roughened and passivated by an insoluble Au-MPA product. > Au is leached into the aqueous electrolyte as a soluble Au-DMSA species ({approx}60 ppb, 12 h). - Abstract: The electrochemical characteristics of polycrystalline Au in LiClO{sub 4} electrolyte solutions containing 3-mercaptopropionic acid (MPA) or meso-2,3-dimercaptosuccinic acid (DMSA) were studied with linear sweep voltammetry (LSV) and electrochemical impedance spectroscopy (EIS) over a wide range of positive potentials vs. Ag/AgCl. The EIS data exhibited linear capacitive behaviour at 0.0 V with either MPA or DMSA added directly to the electrolyte suggesting the formation of an adsorbed layer of the alkylthiol on the electrode surface. Above this potential, a single well-defined impedance loop appeared for electrolyte solutions containing DMSA or MPA, an observation indicative of a charge transfer reaction that could be related to several processes including oxidative desorption, oxidation of the alkylthiol, or Au oxidation/dissolution. To test for Au dissolution, the electrode was held at 0.8 V vs. Ag/AgCl for 12 h in electrolytes containing MPA or DMSA followed by surface analysis with Atomic Force Microscopy and solution analysis with Atomic Absorption Spectroscopy. When the electrolyte contained MPA, the extended potential holding procedure resulted in significant roughening of the electrode with no detectable quantities of Au in the electrolyte. X-ray photoelectron spectroscopy (XPS) analysis of the Au surface revealed an additional species in the Au 4f{sub 7/2} spectrum indicating the presence of an insoluble electrochemically generated Au(I)-MPA species. When the electrolyte contained DMSA, the Au electrode appeared smoother, 56.6 {+-} 9.6 ppb of Au was detected in the electrolyte and the XPS analysis displayed a single species in the