WorldWideScience

Sample records for ats-r information required

  1. Software information sorting code 'PLUTO-R'

    International Nuclear Information System (INIS)

    Tsunematsu, Toshihide; Naraoka, Kenitsu; Adachi, Masao; Takeda, Tatsuoki

    1984-10-01

    A software information sorting code PLUTO-R is developed as one of the supporting codes of the TRITON system for the fusion plasma analysis. The objective of the PLUTO-R code is to sort reference materials of the codes in the TRITON code system. The easiness in the registration of information is especially pursued. As experience and skill in the data registration are not required, this code is usable for construction of general small-scale information system. This report gives an overall description and the user's manual of the PLUTO-R code. (author)

  2. Generalized Information Architecture for Managing Requirements in IBM?s Rational DOORS(r) Application.

    Energy Technology Data Exchange (ETDEWEB)

    Aragon, Kathryn M.; Eaton, Shelley M.; McCornack, Marjorie Turner; Shannon, Sharon A.

    2014-12-01

    When a requirements engineering effort fails to meet expectations, often times the requirements management tool is blamed. Working with numerous project teams at Sandia National Laboratories over the last fifteen years has shown us that the tool is rarely the culprit; usually it is the lack of a viable information architecture with well- designed processes to support requirements engineering. This document illustrates design concepts with rationale, as well as a proven information architecture to structure and manage information in support of requirements engineering activities for any size or type of project. This generalized information architecture is specific to IBM's Rational DOORS (Dynamic Object Oriented Requirements System) software application, which is the requirements management tool in Sandia's CEE (Common Engineering Environment). This generalized information architecture can be used as presented or as a foundation for designing a tailored information architecture for project-specific needs. It may also be tailored for another software tool. Version 1.0 4 November 201

  3. At R407/R408

    CERN Multimedia

    1974-01-01

    R407/R408 were experiments designed by the CERN-Collège de France-Heidelberg-Karlsruhe Collaboration to study two-particle correlations in the fragmentation region requiring a large transverse momentum particle in the forward direction. Atmospheric pressure Cerenkov counters were part of the additional equipment set up during 1974 at the SFM facility. Here Paul Hanke multi-reflected on Cerenkov mirrors.

  4. Technology Requirements for Information Management

    Science.gov (United States)

    Graves, Sara; Knoblock, Craig A.; Lannom, Larry

    2002-01-01

    This report provides the results of a panel study conducted into the technology requirements for information management in support of application domains of particular government interest, including digital libraries, mission operations, and scientific research. The panel concluded that it was desirable to have a coordinated program of R&D that pursues a science of information management focused on an environment typified by applications of government interest - highly distributed with very large amounts of data and a high degree of heterogeneity of sources, data, and users.

  5. A Theory of Information Quality and a Framework for its Implementation in the Requirements Engineering Process

    Science.gov (United States)

    Grenn, Michael W.

    This dissertation introduces a theory of information quality to explain macroscopic behavior observed in the systems engineering process. The theory extends principles of Shannon's mathematical theory of communication [1948] and statistical mechanics to information development processes concerned with the flow, transformation, and meaning of information. The meaning of requirements information in the systems engineering context is estimated or measured in terms of the cumulative requirements quality Q which corresponds to the distribution of the requirements among the available quality levels. The requirements entropy framework (REF) implements the theory to address the requirements engineering problem. The REF defines the relationship between requirements changes, requirements volatility, requirements quality, requirements entropy and uncertainty, and engineering effort. The REF is evaluated via simulation experiments to assess its practical utility as a new method for measuring, monitoring and predicting requirements trends and engineering effort at any given time in the process. The REF treats the requirements engineering process as an open system in which the requirements are discrete information entities that transition from initial states of high entropy, disorder and uncertainty toward the desired state of minimum entropy as engineering effort is input and requirements increase in quality. The distribution of the total number of requirements R among the N discrete quality levels is determined by the number of defined quality attributes accumulated by R at any given time. Quantum statistics are used to estimate the number of possibilities P for arranging R among the available quality levels. The requirements entropy H R is estimated using R, N and P by extending principles of information theory and statistical mechanics to the requirements engineering process. The information I increases as HR and uncertainty decrease, and the change in information AI needed

  6. Health information needs of professional nurses required at the point of care.

    Science.gov (United States)

    Ricks, Esmeralda; ten Ham, Wilma

    2015-06-11

    Professional nurses work in dynamic environments and need to keep up to date with relevant information for practice in nursing to render quality patient care. Keeping up to date with current information is often challenging because of heavy workload, diverse information needs and the accessibility of the required information at the point of care. The aim of the study was to explore and describe the information needs of professional nurses at the point of care in order to make recommendations to stakeholders to develop a mobile library accessible by means of smart phones when needed. The researcher utilised a quantitative, descriptive survey design to conduct this study. The target population comprised 757 professional nurses employed at a state hospital. Simple random sampling was used to select a sample of the wards, units and departments for inclusion in the study. A convenience sample of 250 participants was selected. Two hundred and fifty structured self-administered questionnaires were distributed amongst the participants. Descriptive statistics were used to analyse the data. A total of 136 completed questionnaires were returned. The findings highlighted the types and accessible sources of information. Information needs of professional nurses were identified such as: extremely drug-resistant tuberculosis, multi-drug-resistant tuberculosis, HIV, antiretrovirals and all chronic lifestyle diseases. This study has enabled the researcher to identify the information needs required by professional nurses at the point of care to enhance the delivery of patient care. The research results were used to develop a mobile library that could be accessed by professional nurses.

  7. 78 FR 31769 - Accessible Emergency Information; Apparatus Requirements for Emergency Information and Video...

    Science.gov (United States)

    2013-05-24

    ... and equipment and better access video programming.'' \\7\\ \\7\\ H.R. Rep. No. 111-563, 111th Cong., 2d... Video Accessibility Act of 2010 (``CVAA''), the Commission adopts rules requiring video programming distributors and video programming providers (including program owners) to make televised emergency information...

  8. Health information needs of professional nurses required at the point of care

    Directory of Open Access Journals (Sweden)

    Esmeralda Ricks

    2015-06-01

    Conclusion: This study has enabled the researcher to identify the information needs required by professional nurses at the point of care to enhance the delivery of patient care. The research results were used to develop a mobile library that could be accessed by professional nurses.

  9. Group Centric Networking: Addressing Information Sharing Requirements at the Tactical Edge

    Science.gov (United States)

    2016-04-10

    Group Centric Networking: Addressing Information Sharing Requirements at the Tactical Edge Bow-Nan Cheng, Greg Kuperman, Patricia Deutsch, Logan...been a large push in the U.S. Department of Defense to move to an all Internet Protocol (IP) infrastructure, particularly on the tactical edge . IP and...lossy links, and scaling to large numbers of users. Unfortunately, these are the exact conditions military tactical edge networks must operate within

  10. R and D on seismic emergency information system

    International Nuclear Information System (INIS)

    2001-06-01

    After the Great Hansin-Awaji Earthquake Disaster occurred in 1995, the Science and Technology Agency commenced 'Frontier Research Program on Earthquake' in FY1996. As a part of this research program, four-year program on 'Research on Real-time Earthquake Information Transmission' has been carried out at JAERI since FY1997. Through the experience of the above earthquake disaster, the importance of accurate and prompt seismic information transmission immediately after the occurrence of the earthquake has been recognized from the viewpoint of disaster mitigation. Under this circumstance, the main activity in Real-time Earthquake Information Transmission Research at JAERI has been placed on the development of a seismic emergency information system. In order to respond to the above R and D, Seismic Emergency Information System Research Team was organized in JAERI in FY1998. In the meantime, a part of this R and D program is performed under the coordinated research between JAERI and NIED (National Research Institute for Earth Science and Disaster Prevention). This report summarizes the results of four years program from FY1997 to FY2000 on the above R and D. The R and D has been conducted involving the latest progress in earthquake engineering with regard to estimation techniques on the hypocenter, fault and earthquake motion parameters and in Information Technologies. The R and D was divided into two parts, i.e., development of the basic system and application system. In the basic system, earthquake information with 500 m square mesh in a local area can be estimated and transmitted in a few minutes. In the application system, the concept of the disaster management system which consists of user site and disaster information center and is capable of mutual information transmission has been established. A prototype of the application system, which include the basic system in the disaster information center, has been developed. Test operation of the basic system in being

  11. At R802

    CERN Multimedia

    1974-01-01

    The photo shows on the middle some of the MWPCs of the spectrometer. The experiment R802 was set up by the CERN-Rome Collaboration to study negative particles at angles close to 0 deg. It required special vacuum chambers with enlarged horizontal dimensions and very thin metal windows for insertion in two magnet units adjacent to I-8 (Annual Report 1973 p. 120 and 1974, p. 108). Martin Wensveen stands on the centre, left.

  12. LEGACY MANAGEMENT REQUIRES INFORMATION

    International Nuclear Information System (INIS)

    CONNELL, C.W.; HILDEBRAND, R.D.

    2006-01-01

    ''Legacy Management Requires Information'' describes the goal(s) of the US Department of Energy's Office of Legacy Management (LM) relative to maintaining critical records and the way those goals are being addressed at Hanford. The paper discusses the current practices for document control, as well as the use of modern databases for both storing and accessing the data to support cleanup decisions. In addition to the information goals of LM, the Hanford Federal Facility Agreement and Consent Order, known as the ''Tri-Party Agreement'' (TPA) is one of the main drivers in documentation and data management. The TPA, which specifies discrete milestones for cleaning up the Hanford Site, is a legally binding agreement among the US Department of Energy (DOE), the Washington State Department of Ecology (Ecology), and the US Environmental Protection Agency (EPA). The TPA requires that DOE provide the lead regulatory agency with the results of analytical laboratory and non-laboratory tests/readings to help guide them in making decisions. The Agreement also calls for each signatory to preserve--for at least ten years after the Agreement has ended--all of the records in its or its contractors, possession related to sampling, analysis, investigations, and monitoring conducted. The tools used at Hanford to meet TPA requirements are also the tools that can satisfy the needs of LM

  13. Specifying semantic information on functional requirements

    OpenAIRE

    YAO, WUPING

    2012-01-01

    Requirements engineering is a challenging process in software development projects. Requirements, in general, are documented in natural language. They often have issues related to ambiguity, completeness and consistency. How to improve the quality of requirements documentation remains a classic research topic. This research aims at improving the way of editing and documenting functional requirements. We propose a meta-model to specify the semantic information of functional requirements, and d...

  14. Progress of R and D on seismic emergency information system

    International Nuclear Information System (INIS)

    2000-09-01

    After the Great Hansin-Awaji Earthquake Disaster occurred in 1995, the Science and Technology Agency commenced 'Frontier Research Program on Earthquake' in FY1996. As a part of this research program, four-year program on 'Research on Real-time Earthquake Information Transmission' has been carried out at JAERI since FY1997. Through the experience of the above earthquake disaster, the importance of accurate and prompt seismic information transmission immediately after the occurrence of the earthquake has been recognized from the viewpoint of disaster mitigation. Under this circumstance, the main activity in Real-time Earthquake Information Transmission Research at JAERI has been placed on the development of a seismic emergency information system. In order to respond to the above R and D, Seismic Emergency Information System Research Team was organized in JAERI in FY1998. In the meantime a part of this R and D program is performed under the coordinated research between JAERI and NIED(National Research Institute for Science and Disaster Prevention). This report describes the recent progress of R and D until FY1999. In the R and D, estimation techniques of hypocenter, fault and earthquake motion parameters, in which the latest results in the field of earthquake engineering were involved, were developed. Until the end of FY1999, the main part of the system, in which the above estimation techniques are introduced, is completed. By this system the seismic information is being transmitted using E-mail and homepage through the inter-net. In addition the databases on the estimated earthquake motion parameter distribution under scenario earthquakes and the surface soil amplification function around JAERI-Tokai site are prepared to examine the applicability of the system. (author)

  15. Hydrologic Tests at Characterization Wells R-9i, R-13, R-19, R-22, and R-31, Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    S.G.McLin; W.J. Stone

    2004-06-01

    Hydrologic information is essential for environmental efforts at Los Alamos National Laboratory. Testing at new characterization wells being drilled to the regional aquifer (''R wells'') to improve the conceptual hydrogeologic model of the Pajarito Plateau is providing such information. Field tests were conducted on various zones of saturation penetrated by the R wells to collect data needed for determining hydraulic properties. This document provides details of the design and execution of testing as well as an analysis of data for five new wells: R-9i, R-13, R-19, R-22, and R-31. One well (R-13) was evaluated by a pumping test and the rest (R-9i, R-19, R-22, and R-31) were evaluated by injection tests. Characterization well R-9i is located in Los Alamos Canyon approximately 0.3 mi west of the Route 4/Route 502 intersection. It was completed at a depth of 322 ft below ground surface (bgs) in March 2000. This well was constructed with two screens positioned below the regional water table. Both screens were tested. Screen 1 is completed at about 189-200 ft bgs in fractured basalt, and screen 2 is completed at about 270-280 ft bgs in massive basalt. Specific capacity analysis of the screen 1 data suggests that the fractured basalt has a transmissivity (T) of 589 ft{sup 2}/day and corresponds to a hydraulic conductivity (K) of 7.1 ft/day based on a saturated thickness of 83 ft. The injection test data from the massive basalt near screen 2 were analyzed by the Bouwer-Rice slug test methodology and suggest that K is 0.11 ft/day, corresponding to a T of about 2.8 ft{sup 2}/day based on a saturated thickness of 25 ft. Characterization well R-13 is located in Mortandad Canyon just west of the eastern Laboratory boundary. It was completed at a depth of 1029 ft bgs in February 2002. This well was constructed with one 60-ft long screen positioned about 125 ft below the regional water table. This screen is completed at about 958-1019 ft bgs and straddles the

  16. Organisational and information requirements at the municipal level

    International Nuclear Information System (INIS)

    Mandos, J.L.M.

    1993-01-01

    There are three types of government in The Netherlands: Kingdom, province and municipality. The nuclear power station in Borsele (Pressurised Water Reactor) has a capacity of 488 MW. The basis of disaster relief in The Netherlands is in the hands of the municipality. In 1991 a new disaster relief plan for the nuclear power station in Borsele was prepared. A large scale national exercise took place in November of that year. This disaster relief plan has three levels: local, regional, national. At the regional level seven mayors co-operate in a management team. At the national level there is a management team of ministers. At the regional level the co-ordination of the advice and operational services is executed under the direction of an operational leader (leader of the regional fire-brigade). The advice to the management team of mayors is in the hands of the operational leader. The public generally has a distorted idea about nuclear power and the effects of any possible disaster. This can be a great problem when giving information to the public during a disaster. Reliable information, given in time, is indispensable. Sufficient statistical information must be available. Models, advance calculations and forecasts can be of great help in decision making from the beginning of a serious event. (author)

  17. 32 CFR 298.5 - Information requirements.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Information requirements. 298.5 Section 298.5... OF INFORMATION ACT PROGRAM DEFENSE INVESTIGATIVE SERVICE (DIS) FREEDOM OF INFORMATION ACT PROGRAM § 298.5 Information requirements. The DIS Office of Information and Public Affairs is responsible for...

  18. A Study of Laser System Requirements for Application in Beam Diagnostics And Polarimetry at the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Dixit, S.; Delerue, N.; Foster, B.; Howell, D.F.; Peach, K.; Quelch, G.; Qureshi, M.; Reichold, A.; /Oxford U.; Hirst, G.; Ross, I.; /Rutherford; Urakawa, J.; /KEK,; Soskov, V.; Variola, A.; Zomer, F.; /Orsay, LAL; Blair, G.A.; Boogert, S.T.; Boorman, G.; Bosco, A.; Driouichi, C.; Karataev, P.; /Royal Holloway, U. of London; Brachmann,; /SLAC

    2007-02-12

    Advanced laser systems will be essential for a range of diagnostics devices and polarimetry at the ILC. High average power, high beam quality, excellent stability and reliability will be crucial in order to deliver the information required to attain the necessary ILC luminosity as well as for efficient polarimetry. The key parameters are listed together with the R & D required to achieve the necessary laser system performance.

  19. 22 CFR 126.13 - Required information.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Required information. 126.13 Section 126.13... PROVISIONS § 126.13 Required information. (a) All applications for licenses (DSP-5, DSP-61, DSP-73, and DSP... are multiple consignors, consignees or freight forwarders, and all the required information cannot be...

  20. Ophthalmologists' awareness of informed consent and their compliance to its requirements.

    Science.gov (United States)

    Ehteshami, Asghar; Isfahani, Sakineh Saghaeiannejad; Saeedbakhsh, Saeed; Isfahani, Mahtab Kasaei

    2013-01-01

    Healthcare providers' awareness of laws governing medical documents and patients' health-related information is essential in securing the patients' rights. Given the existing legal problems in documentation of medical record of Consent and Acquittal, we decided to perform an investigation examining the levels of ophthalmologists' awareness of legal requirements for medical record of consent and acquittal and how they complied with such requirements at Feiz Teaching Hospital, Isfahan in the year 2011. This research is an applied, descriptive-analytic one. The research population for awareness measurement includes attending ophthalmologists at Feiz Hospital. Filled-in consent record forms recorded in medical document were used to examine the levels of compliance with legal requirements governing medical record of consent and acquittal. Sampling among the attending ophthalmologists was performed using consensus which included 14 ophthalmologists. The files were samples using the statistical formula, resulting in a sample of 303 files. Data collection tools included a questionnaire and a check list. The questionnaire's reliability was estimated through Cronbach's alpha calculation (0.8); and the check list was completed through a survey among professors of Health Information Technology Management department. In a first step, investigators handed a questionnaire containing 12 items to the ophthalmologists in order to assess their levels of awareness from legal Aspects of medical Informed consent and acquittal, and received the completed questionnaire after answering their possible queries on the issue. In the next step the researchers went to the hospital and evaluated the levels of compliance with legal aspects of medical informed consent and acquittal within the files using a check list and by direct observation. Analytic statistics and SPSS software were used to analyze the data; and Pearson test was applied to evaluate the assumed relationship. The findings were

  1. At R207

    CERN Multimedia

    1975-01-01

    At the centre, a barrel shaped hodoscope surrounds the beams' crossing point. It was previously used for experiments R205 and R206 which did run in 1974. After their completion in mid 1975 the equipment of R205 was removed, and that of R206 was modified and rearranged to create two small angle spectrometers, one on each side of the intersection, for experiment R207 (diffraction dissociation and formation at small momentum transfer), by the CERN-Holland-Manchester Collaboration. (see also photos 7508109X and 7508113X) Here on the right, Lars Leistam.

  2. At R207

    CERN Multimedia

    1975-01-01

    With R207 the CERN-Holland-Manchester Collaboration studied proton-proton diffraction dissociation at small momentum transfer. This followed, at Intersection 2, the study of correlations associated with high transverse momentum particles by Daresbury-Liverpool-RHEL Collaboration (R205) and of multiplicity and rapidity distributions in diffractive collisions by CERN-Holland-Lancaster-Manchester (R206), and used part of the previous set-up.

  3. 49 CFR 451.25 - Required information.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false Required information. 451.25 Section 451.25....25 Required information. (a) The safety approval number appearing on line 1 of the safety approval... safety approval plate on the freight container provided that all the information contained on the...

  4. Itil version 3 at a glance information quick reference

    CERN Document Server

    Long, John

    2008-01-01

    ITILA(R) Version 3 At a Glance takes a graphical approach to consolidating the information of ITILA(R) version 3. ITILA(R) is an internationally-recognized set of best practices for providing IT service management. IT organizations worldwide are implementing ITILA(R) as a vehicle for improving IT service quality and improve return on investment for IT services. The desk referencea (TM)s unique graphical approach will take otherwise complex textual descriptions and make the information accessible in a series of consistent, simple diagrams. ITILA(R) Version 3 At a Glance will be of interest to organizations looking to train their staffs in a consistent and cost-effective way. Further, this book is ideal for anyone involved in planning consulting, implementing, or testing an ITILA(R) Version 3 implementation. Each chapter in ITILA(R) Version 3 at a Glance summarizes one of the ITILA(R) v3 books in the following consistent structure: - Brief Description of the Stage - Overview Diagram of the Stage - Key Concepts ...

  5. At R207

    CERN Multimedia

    CERN PhotoLab

    1976-01-01

    The photo shows the fast electronics racks of the experiment R207 by the CERN-Holland-Manchester Collaboration. R207 aimed at the study of diffraction dissociation and formation at small momentum transfers. Gerjan Bobbink and Alan Rudge stand in front of the racks.

  6. Training Requirements and Information Management System

    Energy Technology Data Exchange (ETDEWEB)

    Cillan, T.F.; Hodgson, M.A.

    1992-05-01

    This is the software user's guide for the Training Requirements and Information Management System. This guide defines and describes the software operating procedures as they apply to the end user of the software program. This guide is intended as a reference tool for the user who already has an indepth knowledge of the Training Requirements and Information Management System functions and data reporting requirement.

  7. 36 CFR 801.7 - Information requirements.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Information requirements. 801.7 Section 801.7 Parks, Forests, and Public Property ADVISORY COUNCIL ON HISTORIC PRESERVATION HISTORIC PRESERVATION REQUIREMENTS OF THE URBAN DEVELOPMENT ACTION GRANT PROGRAM § 801.7 Information...

  8. Requirements elicitation for geo-information solutions

    NARCIS (Netherlands)

    Robbi Sluter, Claudia; van Elzakker, Corné P.J.M.; Ivanova, Ivana

    2017-01-01

    Geo-information solutions can achieve a higher level of quality if they are developed in accordance with a user-centred design that requires definition of the user requirements in the first step of solution construction. We treat a geo-information solution as a system designed to support human-based

  9. Fiscal year 1999 waste information requirements document

    International Nuclear Information System (INIS)

    Adams, M.R.

    1998-01-01

    The Waste Information Requirements Document (WIRD) has the following purposes: To describe the overall drivers that require characterization information and to document their source; To define how characterization is going to satisfy the drivers, close issues, and measure and report progress; and To describe deliverables and acceptance criteria for characterization. Characterization information is required to maintain regulatory compliance, perform operations and maintenance, resolve safety issues, and prepare for disposal of waste. Commitments addressing these requirements are derived from the Hanford Federal Facility Agreement and Consent Order, also known as the Tri-Party Agreement; the Recommendation 93-5 Implementation Plan (DOE-RL 1996a) to the Defense Nuclear Facilities Safety Board (DNFSB); and other requirement sources listed in Section 2.0. The Waste Information Requirements Document replaces the tank waste analysis plans and the tank characterization plan previously required by the Tri-Party Agreement, Milestone M-44-01 and M-44-02 series

  10. Information Models, Data Requirements, and Agile Data Curation

    Science.gov (United States)

    Hughes, John S.; Crichton, Dan; Ritschel, Bernd; Hardman, Sean; Joyner, Ron

    2015-04-01

    The Planetary Data System's next generation system, PDS4, is an example of the successful use of an ontology-based Information Model (IM) to drive the development and operations of a data system. In traditional systems engineering, requirements or statements about what is necessary for the system are collected and analyzed for input into the design stage of systems development. With the advent of big data the requirements associated with data have begun to dominate and an ontology-based information model can be used to provide a formalized and rigorous set of data requirements. These requirements address not only the usual issues of data quantity, quality, and disposition but also data representation, integrity, provenance, context, and semantics. In addition the use of these data requirements during system's development has many characteristics of Agile Curation as proposed by Young et al. [Taking Another Look at the Data Management Life Cycle: Deconstruction, Agile, and Community, AGU 2014], namely adaptive planning, evolutionary development, early delivery, continuous improvement, and rapid and flexible response to change. For example customers can be satisfied through early and continuous delivery of system software and services that are configured directly from the information model. This presentation will describe the PDS4 architecture and its three principle parts: the ontology-based Information Model (IM), the federated registries and repositories, and the REST-based service layer for search, retrieval, and distribution. The development of the IM will be highlighted with special emphasis on knowledge acquisition, the impact of the IM on development and operations, and the use of shared ontologies at multiple governance levels to promote system interoperability and data correlation.

  11. 22 CFR 1203.735-405 - Information required.

    Science.gov (United States)

    2010-04-01

    ... RESPONSIBILITIES AND CONDUCT Statements of Employment and Financial Interests § 1203.735-405 Information required... defined in § 1203.735-102(f). (d) Information not known by employees. If any information required to be... connection with, or interest in, a professional society or a charitable, religious, social, fraternal...

  12. 32 CFR 285.5 - Information requirements.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Information requirements. 285.5 Section 285.5 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DOD FREEDOM OF INFORMATION ACT (FOIA) PROGRAM § 285.5 Information...

  13. Investigation of the current requirements engineering practices among software developers at the Universiti Utara Malaysia Information Technology (UUMIT) centre

    Science.gov (United States)

    Hussain, Azham; Mkpojiogu, Emmanuel O. C.; Abdullah, Inam

    2016-08-01

    Requirements Engineering (RE) is a systemic and integrated process of eliciting, elaborating, negotiating, validating and managing of the requirements of a system in a software development project. UUM has been supported by various systems developed and maintained by the UUM Information Technology (UUMIT) Centre. The aim of this study was to assess the current requirements engineering practices at UUMIT. The main problem that prompted this research is the lack of studies that support software development activities at the UUMIT. The study is geared at helping UUMIT produce quality but time and cost saving software products by implementing cutting edge and state of the art requirements engineering practices. Also, the study contributes to UUM by identifying the activities needed for software development so that the management will be able to allocate budget to provide adequate and precise training for the software developers. Three variables were investigated: Requirement Description, Requirements Development (comprising: Requirements Elicitation, Requirements Analysis and Negotiation, Requirements Validation), and Requirement Management. The results from the study showed that the current practice of requirement engineering in UUMIT is encouraging, but still need further development and improvement because a few RE practices were seldom practiced.

  14. Information requirements for enterprise systems

    OpenAIRE

    Sommerville, Ian; Lock, Russell; Storer, Tim

    2012-01-01

    In this paper, we discuss an approach to system requirements engineering, which is based on using models of the responsibilities assigned to agents in a multi-agency system of systems. The responsibility models serve as a basis for identifying the stakeholders that should be considered in establishing the requirements and provide a basis for a structured approach, described here, for information requirements elicitation. We illustrate this approach using a case study drawn from civil emergenc...

  15. Fleet DNA Brings Fleet Data to Life, Informs R&D | NREL

    Science.gov (United States)

    Fleet DNA Brings Fleet Data to Life, Informs R&D Science and Technology Highlights Highlights in Research & Development Fleet DNA Brings Fleet Data to Life, Informs R&D Key Research Results Achievement Built on over 11.5 million miles of vehicle operations data, Fleet DNA helps users

  16. Restart of R reactor at SRP

    International Nuclear Information System (INIS)

    McDonell, W.R.

    1983-01-01

    Restart of the Savannah River R-Reactor is an alternative to L-Reactor operation for increased production of defense nuclear material. R-Reactor was shut down in 1964 after 11-years operation and has been on standby for 19 years. This report presents a description of R-Reactor operation to serve as a basis for analysis of environmental impacts after restoration to meet current SRP performance standards. R-Reactor operation would differ from L-Reactor operation principally in discharge and recycle of effluent cooling water to Par Pond, rather than direct discharge to the Savannah River by way of Steel Creek. Significant differences in environmental effects could result. A costly renovation program would be required to restore R-Reactor to operability, and the reactor could not contribute to material production before about 1989

  17. Safety Requirements and Modern Technical Requirements in Human Information Systems in Amman Hotels

    OpenAIRE

    Farouq Ahmad Alazzam; Sattam Rakan Allahawiah; Mohammad Nayef Alsarayreh; Kafa Hmoud Abdallah al Nawaiseh

    2015-01-01

    This study aimed to demonstrate the availability of Safety requirements and modern technical requirements in human information systems in Amman hotels. an the most important results of this study is the availability of security and safety requirements in human information systems In Amman hotels and The adequacy of the information that it provided .and show that all departments are not connected by appropriate and effective communication networks in adequate form . Also sophisticated operatin...

  18. Information technology - Security techniques - Information security management systems - Requirements

    CERN Document Server

    International Organization for Standardization. Geneva

    2005-01-01

    ISO/IEC 27001:2005 covers all types of organizations (e.g. commercial enterprises, government agencies, not-for profit organizations). ISO/IEC 27001:2005 specifies the requirements for establishing, implementing, operating, monitoring, reviewing, maintaining and improving a documented Information Security Management System within the context of the organization's overall business risks. It specifies requirements for the implementation of security controls customized to the needs of individual organizations or parts thereof. ISO/IEC 27001:2005 is designed to ensure the selection of adequate and proportionate security controls that protect information assets and give confidence to interested parties. ISO/IEC 27001:2005 is intended to be suitable for several different types of use, including the following: use within organizations to formulate security requirements and objectives; use within organizations as a way to ensure that security risks are cost effectively managed; use within organizations to ensure comp...

  19. rAvis: an R-package for downloading information stored in Proyecto AVIS, a citizen science bird project.

    Science.gov (United States)

    Varela, Sara; González-Hernández, Javier; Casabella, Eduardo; Barrientos, Rafael

    2014-01-01

    Citizen science projects store an enormous amount of information about species distribution, diversity and characteristics. Researchers are now beginning to make use of this rich collection of data. However, access to these databases is not always straightforward. Apart from the largest and international projects, citizen science repositories often lack specific Application Programming Interfaces (APIs) to connect them to the scientific environments. Thus, it is necessary to develop simple routines to allow researchers to take advantage of the information collected by smaller citizen science projects, for instance, programming specific packages to connect them to popular scientific environments (like R). Here, we present rAvis, an R-package to connect R-users with Proyecto AVIS (http://proyectoavis.com), a Spanish citizen science project with more than 82,000 bird observation records. We develop several functions to explore the database, to plot the geographic distribution of the species occurrences, and to generate personal queries to the database about species occurrences (number of individuals, distribution, etc.) and birdwatcher observations (number of species recorded by each collaborator, UTMs visited, etc.). This new R-package will allow scientists to access this database and to exploit the information generated by Spanish birdwatchers over the last 40 years.

  20. 46 CFR 16.500 - Management Information System requirements.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Management Information System requirements. 16.500 Section 16.500 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN CHEMICAL TESTING Management Information System § 16.500 Management Information System requirements. (a...

  1. 32 CFR 216.6 - Information requirements.

    Science.gov (United States)

    2010-07-01

    ...) have been assigned Report Control Symbol DD-P&R-(AR)-2038 in accordance with DoD 8910.1-M 2 . 2 Copies... of) ABC University)] by a policy or practice of the school. Specifically, military recruiting...-recruiting information refers to a student's name, address, telephone listing, age (or year of birth), level...

  2. 26 CFR 1.414(r)-4 - Qualified separate line of business-fifty-employee and notice requirements.

    Science.gov (United States)

    2010-04-01

    ...-employee and notice requirements. 1.414(r)-4 Section 1.414(r)-4 Internal Revenue INTERNAL REVENUE SERVICE... Bonus Plans, Etc. § 1.414(r)-4 Qualified separate line of business—fifty-employee and notice... business (as determined under § 1.414(r)-3) satisfies the 50-employee and notice requirements of § 1.414(r...

  3. Conformational plasticity of the coiled-coil domain of BmrR is required for bmr operator binding: the structure of unliganded BmrR.

    Science.gov (United States)

    Kumaraswami, Muthiah; Newberry, Kate J; Brennan, Richard G

    2010-04-30

    The multidrug-binding transcription regulator BmrR from Bacillus subtilis is a MerR family member that binds to a wide array of cationic lipophilic toxins to activate the transcription of the multidrug efflux pump gene bmr. Transcription activation from the sigma(A)-dependent bmr operator requires BmrR to remodel the nonoptimal 19-bp spacer between the -10 promoter element and the -35 promoter element in order to facilitate productive RNA polymerase binding. Despite the availability of several structures of BmrR bound to DNA and drugs, the lack of a BmrR structure in its unliganded or apo (DNA free and drug free) state hinders our full understanding of the structural transitions required for DNA binding and transcription activation. Here, we report the crystal structure of the constitutively active, unliganded BmrR mutant BmrR(E253Q/R275E). Superposition of the ligand-free (apo BmrR(E253Q/R275E)) and DNA-bound BmrR structures reveals that apo BmrR must undergo significant rearrangement in order to assume the DNA-bound conformation, including an outward rotation of minor groove binding wings, an inward movement of helix-turn-helix motifs, and a downward relocation of pliable coiled-coil helices. Computational analysis of the DNA-free and DNA-bound structures reveals a flexible joint that is located at the center of the coiled-coil helices. This region, which is composed of residues 94 through 98, overlaps the helical bulge that is observed only in the apo BmrR structure. This conformational hinge is likely common to other MerR family members with large effector-binding domains, but appears to be missing from the smaller metal-binding MerR family members. Interestingly, the center-to-center distance of the recognition helices of apo BmrR is 34 A and suggests that the conformational change from the apo BmrR structure to the bmr operator-bound BmrR structure is initiated by the binding of this transcription activator to a more B-DNA-like conformation. (c) 2010 Elsevier

  4. Scintillator concept of NeuLAND at R3B

    Energy Technology Data Exchange (ETDEWEB)

    Aumann, Thomas; Ignatov, Alexander [Technische Universitaet Darmstadt (Germany); Boretzky, Konstanze; Heil, Michael; Simon, Haik [GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); Maroussov, Vassili [Institut fuer Kernphysik, Universitaet zu Koeln (Germany); GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); Zilges, Andreas [Institut fuer Kernphysik, Universitaet zu Koeln (Germany); Collaboration: R3B-Collaboration

    2011-07-01

    For the R3B experiment at FAIR a detection system for fast neutrons, NeuLAND (new Large Area Neutron Detector), is foreseen. Besides a time resolution of {sigma}{sub t}{approx_equal} 100 ps, spatial resolutions of {sigma}{sub x,y,z}{approx_equal} 1 cm, the detection efficiency of above 90% for neutrons of 0.2-1 GeV and a dedicated multi-neutron recognition capability are demanded. Using the FLUKA Monte Carlo code we studied a NeuLAND detector concept relying entirely on bars of a plastic scintillator (BC408). With a detector depth of 2 m the required efficiency is reached and the fraction of incident neutrons detected within resolution requirements varies from {proportional_to}70% to 80% in the desired energy range. Simulations have verified that the introduction of an inactive converter like iron deteriorates the timing performance. Due to the low density of the scintillator secondary protons typically cross several modules, thus allowing the tracking of secondaries. The status of the multi-hit recognition algorithm using the tracking information is presented along with the latest results for the scintillator prototypes for NeuLAND. Using the same framework a competing concept for NeuLAND based on MRPCs was studied as well and is contrasted to the scintillator concept.

  5. Section 508 Electronic Information Accessibility Requirements for Software Development

    Science.gov (United States)

    Ellis, Rebecca

    2014-01-01

    Section 508 Subpart B 1194.21 outlines requirements for operating system and software development in order to create a product that is accessible to users with various disabilities. This portion of Section 508 contains a variety of standards to enable those using assistive technology and with visual, hearing, cognitive and motor difficulties to access all information provided in software. The focus on requirements was limited to the Microsoft Windows® operating system as it is the predominant operating system used at this center. Compliance with this portion of the requirements can be obtained by integrating the requirements into the software development cycle early and by remediating issues in legacy software if possible. There are certain circumstances with software that may arise necessitating an exemption from these requirements, such as design or engineering software using dynamically changing graphics or numbers to convey information. These exceptions can be discussed with the Section 508 Coordinator and another method of accommodation used.

  6. 76 FR 72916 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement...

    Science.gov (United States)

    2011-11-28

    ... information collection requires contractors to comply with the notification process at DFARS clause 252.204... purposes. The U.S.-IAEA Additional Protocol permits the United States unilaterally to declare exclusions from inspection requirements for activities with direct national security significance. The clause at...

  7. Validating TOEFL[R] iBT Speaking and Setting Score Requirements for ITA Screening

    Science.gov (United States)

    Xi, Xiaoming

    2007-01-01

    Although the primary use of the speaking section of the Test of English as a Foreign Language Internet-based test (TOEFL[R] iBT Speaking) is to inform admissions decisions at English medium universities, it may also be useful as an initial screening measure for international teaching assistants (ITAs). This study provides criterion-related…

  8. New GOES-R Risk Reduction Activities at CIRA

    Science.gov (United States)

    Rogers, M. A.; Miller, S. D.; Grasso, L. D.; Haynes, J. M.; NOH, Y. J.; Forsythe, J.; Zupanski, M.; Lindsey, D. T.

    2017-12-01

    A team of atmospheric scientists at the Cooperative Institute for Research in the Atmosphere (CIRA) at the Colorado State University has been selected by the National Oceanic and Atmospheric Administration's (NOAA) GOES-R Risk Reduction (GOES-R3) science program to develop applications to enhance the utilization of the GOES-R sensors, including the Advanced Baseline Imager (ABI) and the Geostationary Lightning Mapper (GLM). The selected project topics follow NOAA's Research and Development Objectives listed in its 5-year Strategic Plan. The projects will be carried out over a three-year period which started on 1 July 2017 and will end on 30 June 2019. CIRA is working on five GOES-R3 application developments: 1) Developing an Environmental Awareness Repertoire of ABI Imagery (`DEAR-ABII') to Advise the Operational Weather Forecaster. DEAR-ABII maximizes the vast potential of the new GOES-R/GOES-16 sensor technology. 2) GOES-R ABI channel differencing used to reveal cloud-free zones of `precursors of convective initiation'. This product identifies where convective initiation may occur in cloud free skies. 3) Improving the ABI Cloud Layers Product for Multiple Layer Cloud Systems and Aviation Forecast Applications. This project aims to improve the GOES-16 cloud layer product by providing information on the boundaries of cloud layers even when one layer overlies another. 4) Using the New Capabilities of GOES-R to Improve Blended, Multisensor Water Vapor Products for Forecasters. GOES-R TPW retrievals will be merged with TPW derived from polar orbiter and surface data to improve the operational NOAA blended TPW product. 5) Data assimilation of GLM observations in HWRF/GSI system. Assimilation of GOES-R GLM observations for the NOAA operational hurricane model with the goal to improve operational hurricane forecasting. Examples for each of these applications will be presented.

  9. 49 CFR 601.45 - Required information.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Required information. 601.45 Section 601.45 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION, FUNCTIONS, AND PROCEDURES Emergency Procedures for Public Transportation Systems § 601.45 Required...

  10. Fiscal year 1997-1998 waste information requirements document

    International Nuclear Information System (INIS)

    Poppiti, J.A.

    1997-01-01

    The Waste Information Requirements Document describes the activities of the Tank Waste Remediation System (TWRS) Characterization Project that provide characterization information on Hanford Site waste tanks. The characterization information is required to perform operations and meet the commitments of TWRS end users. These commitments are derived from the Hanford Federal Facility Agreement and Consent Order, also known as the Tri-Party Agreement; the Recommendation 93-5 Implementation Plan to the Defense Nuclear Facilities Safety Board (DNFSB); and other directives as listed in Section 4.0. This Waste Information Requirement Document applies to Fiscal Years 1997 and 1998 activities. Its contents are based on the best information available in August 1997. The format and content are based on the directions of DOE-RL (Sieracki, 1997) and Fluor Daniel Hanford Incorporated (Umek, 1997). Activities, such as the revision of the Tank Characterization Technical Sampling Basis (Brown et al. 1997), the revision of the data quality objectives (DQOs), issue closures, discussions with Ecology, and management decisions may cause subsequent updates to the Waste Information Requirements Document

  11. 29 CFR 1615.135 - Electronic and information technology requirements.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Electronic and information technology requirements. 1615... INFORMATION TECHNOLOGY § 1615.135 Electronic and information technology requirements. (a) Development, procurement, maintenance, or use of electronic and information technology.—When developing, procuring...

  12. Strategic planning: Identifying organization information requirements

    Energy Technology Data Exchange (ETDEWEB)

    Moise, C.S.

    1993-12-01

    Historically, information resource management has been left to the ``data processing`` arm of the organization. With technological movements away from centralized mainframe-based information processing toward distributed client/server-based information processing, almost every part of an organization is becoming more involved with the information technology itself, and certainly more involved with budgeting for the technology. However, users and buyers of information technology frequently remain dependent upon the information systems department for planning what users need and should buy. This paper reviews techniques for identifying requirements throughout an organization and structuring information resources to meet organizational needs. This will include basing information resource needs on meeting business needs, utilizing ``internal`` and ``external`` information resource planners, using information mapping, assessing information resources, and developing partnerships.

  13. Fleet DNA Brings Fleet Data to Life, Informs R&D | News | NREL

    Science.gov (United States)

    Fleet DNA Brings Fleet Data to Life, Informs R&D Fleet DNA Brings Fleet Data to Life, Informs R De La Rosa, NREL 34672 The Fleet DNA clearinghouse of commercial vehicle operations data features Odyne-have tapped into Fleet DNA." The data-driven insight and decision-making capabilities

  14. 78 FR 65695 - 30-Day Notice of Proposed Information Collection: Technical Processing Requirements for...

    Science.gov (United States)

    2013-11-01

    ... Information Collection: Technical Processing Requirements for Multifamily Project Mortgage Insurance AGENCY: Office of the Chief Information Officer, HUD. ACTION: Correction, notice. SUMMARY: On October 25, 2013 at... Collection Title of Information Collection: Technical Processing Requirements for Multifamily Project...

  15. 26 CFR 1.414(r)-1 - Requirements applicable to qualified separate lines of business.

    Science.gov (United States)

    2010-04-01

    ... lines of business. 1.414(r)-1 Section 1.414(r)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT... Plans, Etc. § 1.414(r)-1 Requirements applicable to qualified separate lines of business. (a) In general. Section 414(r) prescribes the conditions under which an employer is treated as operating qualified...

  16. The information activity of rail passenger information staff: a foundation for information system requirements

    Directory of Open Access Journals (Sweden)

    Martin Rose

    2006-01-01

    Full Text Available Introduction. This paper examines the goal-directed information activity of passenger information staff, working in the dynamic environment of rail network control. The explicit aim is to define a meaningful set of information system requirements. The report shows how dynamic situations may lead us to question a number of established theories of information science. Method. Passenger information officers (PIOs were observed on duty within the rail command and control headquarters. Observation sessions totally eight hours involved the manual recording of sequential information flows and the associated activity of PIOs. A semi-structured management interview was also conducted to provide further insight into the organizational context. Analysis. A viewpoint-oriented analysis technique was used to analyse sequential data captured during observation sessions. Event sequences that represent and explain the viewpoints were identified and elaborated into detailed scenario descriptions. Results. The analysis both supports and contests a number of established theories from information science. Additionally, a range of 'mandatory' and 'desirable' system requirements are derived from the scenario and viewpoint analyses. Conclusion. Dynamic situations have a significant impact on information behaviour which is not always predicted by current theories of information science.

  17. 49 CFR 397.73 - Public information and reporting requirements.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Public information and reporting requirements. 397.73 Section 397.73 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL... Hazardous Materials § 397.73 Public information and reporting requirements. (a) Public information...

  18. Leadership Under Challenge: Information Technology R&D in a Competitive World. An Assessment of the Federal Networking and Information Technology R&D Program

    National Research Council Canada - National Science Library

    Marburger, John H; Kvamme, E. F; Scalise, George; Reed, Daniel A

    2007-01-01

    ...).That leadership is essential to U.S. economic prosperity, security, and quality of life. This report presents a formal assessment of the Federal Networking and Information Technology R&D (NITRD...

  19. Automatic sorting of toxicological information into the IUCLID (International Uniform Chemical Information Database) endpoint-categories making use of the semantic search engine Go3R.

    Science.gov (United States)

    Sauer, Ursula G; Wächter, Thomas; Hareng, Lars; Wareing, Britta; Langsch, Angelika; Zschunke, Matthias; Alvers, Michael R; Landsiedel, Robert

    2014-06-01

    The knowledge-based search engine Go3R, www.Go3R.org, has been developed to assist scientists from industry and regulatory authorities in collecting comprehensive toxicological information with a special focus on identifying available alternatives to animal testing. The semantic search paradigm of Go3R makes use of expert knowledge on 3Rs methods and regulatory toxicology, laid down in the ontology, a network of concepts, terms, and synonyms, to recognize the contents of documents. Search results are automatically sorted into a dynamic table of contents presented alongside the list of documents retrieved. This table of contents allows the user to quickly filter the set of documents by topics of interest. Documents containing hazard information are automatically assigned to a user interface following the endpoint-specific IUCLID5 categorization scheme required, e.g. for REACH registration dossiers. For this purpose, complex endpoint-specific search queries were compiled and integrated into the search engine (based upon a gold standard of 310 references that had been assigned manually to the different endpoint categories). Go3R sorts 87% of the references concordantly into the respective IUCLID5 categories. Currently, Go3R searches in the 22 million documents available in the PubMed and TOXNET databases. However, it can be customized to search in other databases including in-house databanks. Copyright © 2013 Elsevier Ltd. All rights reserved.

  20. 77 FR 64952 - Proposed Information Collection; Comment Request; State Government Research and Development (R&D...

    Science.gov (United States)

    2012-10-24

    ..., DC 20230 (or via the Internet at [email protected] ). FOR FURTHER INFORMATION CONTACT: Requests for... obtain information on such things as expenditures according to source of funding, by performer of the..., transportation, etc), by character of work (i.e., basic research, applied research, or development), and by R&D...

  1. Nutrient fluxes at the landscape level and the R* rule

    Science.gov (United States)

    Ju, Shu; DeAngelis, Donald L.

    2010-01-01

    Nutrient cycling in terrestrial ecosystems involves not only the vertical recycling of nutrients at specific locations in space, but also biologically driven horizontal fluxes between different areas of the landscape. This latter process can result in net accumulation of nutrients in some places and net losses in others. We examined the effects of such nutrient-concentrating fluxes on the R* rule, which predicts that the species that can survive in steady state at the lowest level of limiting resource, R*, can exclude all competing species. To study the R* rule in this context, we used a literature model of plant growth and nutrient cycling in which both nutrients and light may limit growth, with plants allocating carbon and nutrients between foliage and roots according to different strategies. We incorporated the assumption that biological processes may concentrate nutrients in some parts of the landscape. We assumed further that these processes draw nutrients from outside the zone of local recycling at a rate proportional to the local biomass density. Analysis showed that at sites where there is a sufficient biomass-dependent accumulation of nutrients, the plant species with the highest biomass production rates (roughly corresponding to the best competitors) do not reduce locally available nutrients to a minimum concentration level (that is, minimum R*), as expected from the R* rule, but instead maximize local nutrient concentration. These new results require broadening of our understanding of the relationships between nutrients and vegetation competition on the landscape level. The R* rule is replaced by a more complex criterion that varies across a landscape and reduces to the R* rule only under certain limiting conditions.

  2. Requirements for Interoperability in Healthcare Information Systems

    Directory of Open Access Journals (Sweden)

    Rita Noumeir

    2012-01-01

    Full Text Available Interoperability is a requirement for the successful deployment of Electronic Health Records (EHR. EHR improves the quality of healthcare by enabling access to all relevant information at the diagnostic decision moment, regardless of location. It is a system that results from the cooperation of several heterogeneous distributed subsystems that need to successfully exchange information relative to a specific healthcare process. This paper analyzes interoperability impediments in healthcare by first defining them and providing concrete healthcare examples, followed by discussion of how specifications can be defined and how verification can be conducted to eliminate those impediments and ensure interoperability in healthcare. This paper also analyzes how Integrating the Healthcare Enterprise (IHE has been successful in enabling interoperability, and identifies some neglected aspects that need attention.

  3. AFSC Laboratory Management Information Requirements Project

    National Research Council Canada - National Science Library

    1982-01-01

    This document was developed under the auspices of the Laboratory IRM (LIRM) Management Working Group in response to AFSC Program Directive 0008-81-1, Management Information Requirement Project (23 February 1981...

  4. 76 FR 76917 - Homeless Management Information Systems Requirements

    Science.gov (United States)

    2011-12-09

    ...-P-01] Homeless Management Information Systems Requirements AGENCY: Office of the Assistant Secretary... for the establishment of regulations for Homeless Management Information Systems (HMIS), which are the... community development, Homeless, Information technology system, Management system, Nonprofit organizations...

  5. System requirement specifications for the Z-plant materials information tracking system (ZMITS)

    International Nuclear Information System (INIS)

    NEGIN, C.A.

    1999-01-01

    This is a system requirement specification for a database which will be developed to track classified information related to nuclear materials stored at PFP. The system will supplement existing databases to support both processing and disposition information needs

  6. 48 CFR 311.7000 - Defining electronic information technology requirements.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Defining electronic information technology requirements. 311.7000 Section 311.7000 Federal Acquisition Regulations System HEALTH... Accessibility Standards 311.7000 Defining electronic information technology requirements. HHS staff that define...

  7. Training Requirements and Information Management System. Software user guide

    Energy Technology Data Exchange (ETDEWEB)

    Cillan, T.F.; Hodgson, M.A.

    1992-05-01

    This is the software user`s guide for the Training Requirements and Information Management System. This guide defines and describes the software operating procedures as they apply to the end user of the software program. This guide is intended as a reference tool for the user who already has an indepth knowledge of the Training Requirements and Information Management System functions and data reporting requirement.

  8. Data mining and business analytics with R

    CERN Document Server

    Ledolter, Johannes

    2013-01-01

    Collecting, analyzing, and extracting valuable information from a large amount of data requires easily accessible, robust, computational and analytical tools. Data Mining and Business Analytics with R utilizes the open source software R for the analysis, exploration, and simplification of large high-dimensional data sets. As a result, readers are provided with the needed guidance to model and interpret complicated data and become adept at building powerful models for prediction and classification. Highlighting both underlying concepts and practical computational skills, Data Mining

  9. Teaching Management Information Systems as a General Education Requirement (GER) Capstone

    Science.gov (United States)

    Hoanca, Bogdan

    2012-01-01

    Although many IS programs nationwide use capstone courses in the major, this paper reports on the use of an upper division Management Information Systems (MIS) class as a general education requirements (GER) capstone. The class is a core requirement for all majors in the Bachelor of Business Administration (BBA) program at the University of Alaska…

  10. Conformational plasticity of the coiled coil domain of BmrR is required for bmr operator binding - the structure of unliganded BmrR

    OpenAIRE

    Kumaraswami, Muthiah; Newberry, Kate J.; Brennan, Richard G.

    2010-01-01

    The multidrug-binding transcription regulator, BmrR, from Bacillus subtilis is a MerR family member that binds to a wide array of cationic lipophilic toxins to activate transcription of the multidrug efflux pump gene, bmr. Transcription activation from the σA-dependent bmr operator requires BmrR to remodel the nonoptimal 19 base pair spacer between the −10 and −35 promoter elements in order to facilitate productive RNA polymerase binding. Despite the availability of several structures of BmrR...

  11. Implementation of the Clean Air Act, Title III, Section 112(r) Prevention of Accidental Release Rule requirements at U.S. DOE Oak Ridge Reservation facilities

    International Nuclear Information System (INIS)

    Humphreys, M.P.

    1997-01-01

    Title III, Section 112(r) of the Clean Air Act (CAA) Amendments of 1990 requires the Environmental Protection Agency (EPA) to promulgate regulations to prevent accidental releases of regulated substances and to reduce the severity of those releases that do occur. The final EPA rule for Risk Management Programs under Section 112(r)(7) of the CAA, promulgated June 20, 1996, applies to all stationary sources with processes that contain more than a threshold quantity of any of 139 regulated substances listed under 40 CFR 68.130. All affected sources will be required to prepare a risk management plan which must be submitted to EPA and be made available to state and local governments and to the public. This paper will provide details of initiatives underway at US Department of Energy (DOE) Oak Ridge Reservation (ORR) Facilities for implementation of the Prevention of Accidental Release Rule. The ORR encompasses three DOE Facilities: the Y-12 Plant, Oak Ridge National Laboratory (ORNL), and the K-25 Site. The Y-12 Plant manufactures component parts for the national nuclear weapons program; the ORNL is responsible for research and development activities including nuclear engineering, engineering technologies, and the environmental sciences; and the K-25 Site conducts a variety of research and development activities and is the home of a mixed waste incinerator. ORR activities underway and soon to be undertaken toward implementation of the Prevention of Accidental Release Rule include: compilation of inventories of regulated substances at all processes at each of the three ORR Facilities for determination of affected processes and facilities; plans for inventory reduction to levels below threshold quantities, where necessary and feasible; determination of the overlap of processes subject to the OSHA PSM Standard and determination of parallel requirements; preparation of Risk Management Plans and Programs for affected processes and facilities including detailed requirements

  12. Required Assets for a Nuclear Energy Applied R&D Program

    Energy Technology Data Exchange (ETDEWEB)

    Harold F. McFarlane; Craig L. Jacobson

    2009-03-01

    This report is one of a set of three documents that have collectively identified and recommended research and development capabilities that will be required to advance nuclear energy in the next 20 to 50 years. The first report, Nuclear Energy for the Future: Required Research and Development Capabilities—An Industry Perspective, was produced by Battelle Memorial Institute at the request of the Assistant Secretary of Nuclear Energy. That report, drawn from input by industry, academia, and Department of Energy laboratories, can be found in Appendix 5.1. This Idaho National Laboratory report maps the nuclear-specific capabilities from the Battelle report onto facility requirements, identifying options from the set of national laboratory, university, industry, and international facilities. It also identifies significant gaps in the required facility capabilities. The third document, Executive Recommendations for Nuclear R&D Capabilities, is a letter report containing a set of recommendations made by a team of senior executives representing nuclear vendors, utilities, academia, and the national laboratories (at Battelle’s request). That third report can be found in Appendix 5.2. The three reports should be considered as set in order to have a more complete picture. The basis of this report was drawn from three sources: previous Department of Energy reports, workshops and committee meetings, and expert opinion. The facilities discussed were winnowed from several hundred facilities that had previously been catalogued and several additional facilities that had been overlooked in past exercises. The scope of this report is limited to commercial nuclear energy and those things the federal government, or more specifically the Office of Nuclear Energy, should do to support its expanded deployment in order to increase energy security and reduce carbon emissions. In the context of this report, capabilities mean innovative, well-structured research and development programs

  13. Recording Information on Architectural Heritage Should Meet the Requirements for Conservation Digital Recording Practices at the Summer Palace

    Science.gov (United States)

    Zhang, L.; Cong, Y.; Wu, C.; Bai, C.; Wu, C.

    2017-08-01

    The recording of Architectural heritage information is the foundation of research, conservation, management, and the display of architectural heritage. In other words, the recording of architectural heritage information supports heritage research, conservation, management and architectural heritage display. What information do we record and collect and what technology do we use for information recording? How do we determine the level of accuracy required when recording architectural information? What method do we use for information recording? These questions should be addressed in relation to the nature of the particular heritage site and the specific conditions for the conservation work. In recent years, with the rapid development of information acquisition technology such as Close Range Photogrammetry, 3D Laser Scanning as well as high speed and high precision Aerial Photogrammetry, many Chinese universities, research institutes and heritage management bureaux have purchased considerable equipment for information recording. However, the lack of understanding of both the nature of architectural heritage and the purpose for which the information is being collected has led to several problems. For example: some institutions when recording architectural heritage information aim solely at high accuracy. Some consider that advanced measuring methods must automatically replace traditional measuring methods. Information collection becomes the purpose, rather than the means, of architectural heritage conservation. Addressing these issues, this paper briefly reviews the history of architectural heritage information recording at the Summer Palace (Yihe Yuan, first built in 1750), Beijing. Using the recording practices at the Summer Palace during the past ten years as examples, we illustrate our achievements and lessons in recording architectural heritage information with regard to the following aspects: (buildings') ideal status desired, (buildings') current status

  14. 26 CFR 1.414(r)-6 - Qualified separate line of business-administrative scrutiny requirement-individual determinations.

    Science.gov (United States)

    2010-04-01

    ...-administrative scrutiny requirement-individual determinations. 1.414(r)-6 Section 1.414(r)-6 Internal Revenue... Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.414(r)-6 Qualified separate line of business... determined under § 1.414(r)-3) that does not satisfy any of the safe harbors in § 1.414(r)-5 for a testing...

  15. [Development of a System to Use Patient's Information Which is Required at the Radiological Department].

    Science.gov (United States)

    Satoh, Akihiro

    2016-04-01

    The purpose of this study is to develop a new system to get and share some data of a patient which are required for a radiological examination not using an electronic medical chart or a radiological information system (RIS), and also to demonstrate that this system is operated on cloud technology. I used Java Enterprise Edition (Java EE) as a programing language and MySQL as a server software, and I used two laptops as hardware for client computer and server computer. For cloud computing, I hired a server of Google App Engine for Java (GAE). As a result, I could get some data of the patient required at his/her examination instantly using this system. This system also helps to improve the efficiency of examination. For example, it has been useful when I want to decide radiographic condition or to create CT images such as multi-planar reconstruction (MPR) or volume rendering (VR). When it comes to cloud computing, the GAE was used experimentally due to some legal restrictions. From the above points it is clear that this system has played an important role in radiological examinations, but there has been still few things which I have to resolve for cloud computing.

  16. A closer look at the R{sub D} and R{sub D{sup ∗}} anomalies

    Energy Technology Data Exchange (ETDEWEB)

    Bardhan, Debjyoti [Department of Theoretical Physics, Tata Institute of Fundamental Research, 1 Homi Bhabha Road, Mumbai 400005 (India); Byakti, Pritibhajan [Department of Theoretical Physics, Indian Association for the Cultivation of Science,2A & 2B, Raja S.C. Mullick Road, Jadavpur, Kolkata 700 032 (India); Ghosh, Diptimoy [Department of Particle Physics and Astrophysics, Weizmann Institute of Science, Rehovot 76100 (Israel)

    2017-01-27

    The measurement of R{sub D} (R{sub D{sup ∗}}), the ratio of the branching fraction of B̄→Dτν̄{sub τ}(B̄→D{sup ∗}τν̄{sub τ}) to that of B̄→Dlν̄{sub l}(B̄→D{sup ∗}lν̄{sub l}), shows 1.9σ(3.3σ) deviation from its Standard Model (SM) prediction. The combined deviation is at the level of 4σ according to the Heavy Flavour Averaging Group (HFAG). In this paper, we perform an effective field theory analysis (at the dimension 6 level) of these potential New Physics (NP) signals assuming SU(3){sub C}×SU(2){sub L}×U(1){sub Y} gauge invariance. We first show that, in general, R{sub D} and R{sub D{sup ∗}} are theoretically independent observables and hence, their theoretical predictions are not correlated. We identify the operators that can explain the experimental measurements of R{sub D} and R{sub D{sup ∗}} individually and also together. Motivated by the recent measurement of the τ polarisation in B̄→D{sup ∗}τν̄{sub τ} decay, P{sub τ}(D{sup ∗}) by the Belle collaboration, we study the impact of a more precise measurement of P{sub τ}(D{sup ∗}) (and a measurement of P{sub τ}(D)) on the various possible NP explanations. Furthermore, we show that the measurement of R{sub D{sup ∗}} in bins of q{sup 2}, the square of the invariant mass of the lepton-neutrino system, along with the information on τ polarisation and the forward-backward asymmetry of the τ lepton, can completely distinguish the various operator structures. We also provide the full expressions of the double differential decay widths for the individual τ helicities in the presence of all the 10 dimension-6 operators that can contribute to these decays.

  17. Potential information requirements for spent nuclear fuel

    International Nuclear Information System (INIS)

    Disbrow, J.A.

    1991-01-01

    This paper reports that the Energy Information Administration (EIA) has performed analyses of the requirements for data and information for the management of commercial spent nuclear fuel (SNF) designated for disposal under the Nuclear Waste Policy Act (NWPA). Subsequently, the EIA collected data on the amounts and characteristics of SNF stored at commercial nuclear facilities. Most recently, the EIA performed an analysis of the international and domestic laws and regulations which have been established to ensure the safeguarding, accountability, and safe management of special nuclear materials (SNM). The SNM of interest are those designated for permanent disposal by the NWPA. This analysis was performed to determine what data and information may be needed to fulfill the specific accountability responsibilities of the Department of Energy (DOE) related to SNF handling, transportation, storage and disposal; to work toward achieving a consistency between nuclear fuel assembly identifiers and material weights as reported by the various responsible parties; and to assist in the revision of the Nuclear Fuel Data Form RW-859 used to obtain spent nuclear fuel characteristics data from the nuclear utilities

  18. Data Requirements and the Basis for Designing Health Information Kiosks.

    Science.gov (United States)

    Afzali, Mina; Ahmadi, Maryam; Mahmoudvand, Zahra

    2017-09-01

    Health kiosks are an innovative and cost-effective solution that organizations can easily implement to help educate people. To determine the data requirements and basis for designing health information kiosks as a new technology to maintain the health of society. By reviewing the literature, a list of information requirements was provided in 4 sections (demographic information, general information, diagnostic information and medical history), and questions related to the objectives, data elements, stakeholders, requirements, infrastructures and the applications of health information kiosks were provided. In order to determine the content validity of the designed set, the opinions of 2 physicians and 2 specialists in medical informatics were obtained. The test-retest method was used to measure its reliability. Data were analyzed using SPSS software. In the proposed model for Iran, 170 data elements in 6 sections were presented for experts' opinion, which ultimately, on 106 elements, a collective agreement was reached. To provide a model of health information kiosk, creating a standard data set is a critical point. According to a survey conducted on the various literature review studies related to the health information kiosk, the most important components of a health information kiosk include six categories; information needs, data elements, applications, stakeholders, requirements and infrastructure of health information kiosks that need to be considered when designing a health information kiosk.

  19. The study on knowledge transferring incentive for information system requirement development

    Energy Technology Data Exchange (ETDEWEB)

    Li, Yang [School of Economics and Business Administration, Chongqing University (China)

    2015-03-10

    Information system requirement development is a process of users’ knowledge sharing and transferring. However the tacit requirements developing is a main problem during requirement development process, for the reason of difficult to encoding, express, and communicate. Knowledge fusion and corporate effort is needed to finding tacit requirements. Under this background, our paper try to find out the rule of effort dynamic evolutionary of software developer and user by building an evolutionary game model on the condition of incentive system. And in addition this paper provides an in depth discussion at the end of this paper.

  20. The study on knowledge transferring incentive for information system requirement development

    International Nuclear Information System (INIS)

    Li, Yang

    2015-01-01

    Information system requirement development is a process of users’ knowledge sharing and transferring. However the tacit requirements developing is a main problem during requirement development process, for the reason of difficult to encoding, express, and communicate. Knowledge fusion and corporate effort is needed to finding tacit requirements. Under this background, our paper try to find out the rule of effort dynamic evolutionary of software developer and user by building an evolutionary game model on the condition of incentive system. And in addition this paper provides an in depth discussion at the end of this paper

  1. Documentation of the workshop on R and D and application of seismic emergency information system

    International Nuclear Information System (INIS)

    2000-07-01

    This report describes the summary of the workshop on R and D and application of Seismic Emergency Information System (SEIS) organized by Japan Atomic Energy Research Institute (JAERI) and National Research Institute for Earth Science and Disaster Prevention (NIED) held on December 20, 1999. Documents presented in the workshop are attached. The workshop consists of the following five technical sessions. - Session I: Objectives of Workshop, - Session II: Progress of R and D of SEIS, - Session III: Current status of application of Seismic Information Systems, - Session IV: Free-discussion for issues and future prospects of Information Systems, - Session V: Briefing, Subsequently to the introduction of objectives of the workshop, the four topics on the progress of R and D of the seismic information system were presented by JAERI and NIED. The discussions are summarized in three viewpoints, i.e.; utilization of the potential of JAERI activities to the R and D, clarification on the objectives and philosophy of the system, effective utilization of the result of R and D. In addition, the current status on the application of seismic information systems was presented by staffs of local government and etc. Issues and future prospects of the information systems were discussed. The workshop was summarized in the final session. (author)

  2. Mediating Informal Care Online: Findings from an Extensive Requirements Analysis

    Directory of Open Access Journals (Sweden)

    Christiane Moser

    2015-05-01

    Full Text Available Organizing and satisfying the increasing demand for social and informal care for older adults is an important topic. We aim at building a peer-to-peer exchange platform that empowers older adults to benefit from receiving support for daily activities and reciprocally offering support to others. In situated interviews and within a survey we investigated the requirements and needs of 246 older adults with mild impairments. Additionally, we conducted an interpretative role analysis of older adults’ collaborative care processes (i.e., support exchange practices in order to identify social roles and understand the inherent expectations towards the execution of support. We will describe our target group in the form of personas and different social roles, as well as user requirements for establishing a successful peer-to-peer collaboration. We also consider our finding from the perspective of social capital theory that allows us to describe in our requirements how relationships provide valuable social resources (i.e., social capital for informal and social care.

  3. RNase MRP is required for entry of 35S precursor rRNA into the canonical processing pathway.

    Science.gov (United States)

    Lindahl, Lasse; Bommankanti, Ananth; Li, Xing; Hayden, Lauren; Jones, Adrienne; Khan, Miriam; Oni, Tolulope; Zengel, Janice M

    2009-07-01

    RNase MRP is a nucleolar RNA-protein enzyme that participates in the processing of rRNA during ribosome biogenesis. Previous experiments suggested that RNase MRP makes a nonessential cleavage in the first internal transcribed spacer. Here we report experiments with new temperature-sensitive RNase MRP mutants in Saccharomyces cerevisiae that show that the abundance of all early intermediates in the processing pathway is severely reduced upon inactivation of RNase MRP. Transcription of rRNA continues unabated as determined by RNA polymerase run-on transcription, but the precursor rRNA transcript does not accumulate, and appears to be unstable. Taken together, these observations suggest that inactivation of RNase MRP blocks cleavage at sites A0, A1, A2, and A3, which in turn, prevents precursor rRNA from entering the canonical processing pathway (35S > 20S + 27S > 18S + 25S + 5.8S rRNA). Nevertheless, at least some cleavage at the processing site in the second internal transcribed spacer takes place to form an unusual 24S intermediate, suggesting that cleavage at C2 is not blocked. Furthermore, the long form of 5.8S rRNA is made in the absence of RNase MRP activity, but only in the presence of Xrn1p (exonuclease 1), an enzyme not required for the canonical pathway. We conclude that RNase MRP is a key enzyme for initiating the canonical processing of precursor rRNA transcripts, but alternative pathway(s) might provide a backup for production of small amounts of rRNA.

  4. System requirements specification for waste information and control system

    International Nuclear Information System (INIS)

    Harris, R.R.

    1994-09-01

    This document defines the requirements for the Waste Information and Control System (WICS). The document defines the functions, constraints, and objectives that pertain to WICS. This shall serve as the baseline document to ensure the needs of the Hazardous Material Control group (HMC) at 222-S Laboratory are met with regard to assurance of accuracy and quality of data taken with WICS

  5. Establishing functional requirements for emergency management information systems

    Energy Technology Data Exchange (ETDEWEB)

    Reed, J.H.; Rogers, G.O.; Sorensen, J.H.

    1991-01-01

    The advancement of computer technologies has led to the development of a number of emergency management information systems (e.g., EIS, CAMEO, IEMIS). The design of these systems has tended to be technologically driven rather than oriented to meeting information management needs during an emergency. Of course, emergency management needs vary depending on the characteristics of the emergency. For example, in hurricanes, onset is typically slow enough to allow emergency managers to simulate evacuations dynamically while in chemical disasters onset may be sufficiently rapid to preclude such simulation(s). This paper describes a system design process in which the analysis of widely recognized emergency management functions was used to identify information requirements and the requisite software and hardware capabilities to deal with rapid onset, low probability, high consequence events. These requirements were then implemented as a prototype emergency management system using existing hardware and software to assure feasibility. Data, hardware, and software requirements were further developed, refined, and made more concrete through an iterative prototyping effort. This approach focuses attention directly on meeting emergency management information needs while avoiding unneeded technological innovations. 10 refs., 4 figs., 1 tab.

  6. 30 CFR 291.110 - Who may MMS require to produce information?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Who may MMS require to produce information? 291... § 291.110 Who may MMS require to produce information? (a) MMS may require any lessee, operator of a lease or unit, shipper, grantee, or transporter to provide information that MMS believes is necessary to...

  7. Specific requirements of GS-R3 related to process implementation

    International Nuclear Information System (INIS)

    Florescu, N.

    2009-01-01

    The PowerPoint presentation gives: an overview of IAEA management system requirements or topics; - the requirements specific to processes and process implementation; - the key practical challenge of using the process approach specified in IAEA SG GS-G3.1 and GS-G3.5. The following items are thoroughly discussed: - Requirements related to specific process implementation and developing processes; - Process management; Generic management; - System processes: - Control of documents; Control of products; Control of records; - Purchasing; - Communication; - Managing organizational change; - Other requirements concerning the process management system; - General management system; - Grading; - Documentation; - Fulfilling the requirements of interested parties; - Management responsibility; - Planning responsibility and authority for the management system monitoring and measurement; - Independent assessment; - Management system review; - Non-conformances, corrective and preventive actions; - Improvement key practical challenge of using the process approach specified in IAEA SG GS-G3.1 and GS-G3.5; - Key challenge: - Process common to all stages; - Phases of process development proposed by IAEA. The following conclusions complete the presentation: GS-R-3 sets basic requirements for process-based integrated management system; - Some key generic processes required, no specific process model favoured namely, no reference to management, core and support processes; - Up to organization to determine appropriate process model; - Easily applicable to a wide range of facilities and activities, including those of a regulatory body; - Specific requirements are found in specific Safety Guide. (author)

  8. R-parity violation at the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Dercks, Daniel [Universitaet Bonn, Physikalisches Institut, Bethe Center for Theoretical Physics, Bonn (Germany); Universitaet Hamburg, II. Institut fuer Theoretische Physik, Hamburg (Germany); Dreiner, Herbi; Krauss, Manuel E.; Opferkuch, Toby; Reinert, Annika [Universitaet Bonn, Physikalisches Institut, Bethe Center for Theoretical Physics, Bonn (Germany)

    2017-12-15

    We investigate the phenomenology of the MSSM extended by a single R-parity-violating coupling at the unification scale. For all R-parity-violating couplings, we discuss the evolution of the particle spectra through the renormalization group equations and the nature of the lightest supersymmetric particle (LSP) within the CMSSM, as an example of a specific complete supersymmetric model. We use the nature of the LSP to classify the possible signatures. For each possible scenario we present in detail the current LHC bounds on the supersymmetric particle masses, typically obtained using simplified models. From this we determine the present coverage of R-parity-violating models at the LHC. We find several gaps, in particular for a stau-LSP, which is easily obtained in R-parity-violating models. Using the program CheckMATE we recast existing LHC searches to set limits on the parameters of all R-parity-violating CMSSMs. We find that virtually all of them are either more strongly constrained or similarly constrained in comparison to the R-parity-conserving CMSSM, including the anti U anti D anti D models. For each R-parity-violating CMSSM we then give the explicit lower mass bounds on all relevant supersymmetric particles. (orig.)

  9. Information security requirements in patient-centred healthcare support systems.

    Science.gov (United States)

    Alsalamah, Shada; Gray, W Alex; Hilton, Jeremy; Alsalamah, Hessah

    2013-01-01

    Enabling Patient-Centred (PC) care in modern healthcare requires the flow of medical information with the patient between different healthcare providers as they follow the patient's treatment plan. However, PC care threatens the stability of the balance of information security in the support systems since legacy systems fall short of attaining a security balance when sharing their information due to compromises made between its availability, integrity, and confidentiality. Results show that the main reason for this is that information security implementation in discrete legacy systems focused mainly on information confidentiality and integrity leaving availability a challenge in collaboration. Through an empirical study using domain analysis, observations, and interviews, this paper identifies a need for six information security requirements in legacy systems to cope with this situation in order to attain the security balance in systems supporting PC care implementation in modern healthcare.

  10. A combination of luxR1 and luxR2 genes activates Pr-promoters of psychrophilic Aliivibrio logei lux-operon independently of chaperonin GroEL/ES and protease Lon at high concentrations of autoinducer.

    Science.gov (United States)

    Konopleva, Maria N; Khrulnova, Svetlana A; Baranova, Ancha; Ekimov, Leonid V; Bazhenov, Sergey V; Goryanin, Ignatiy I; Manukhov, Ilya V

    2016-05-13

    Lux-operon of psychrophilic bacteria Aliivibrio logei contains two copies of luxR and is regulated by Type I quorum sensing (QS). Activation of lux-operon of psychrophilic bacteria A. logei by LuxR1 requires about 100 times higher concentrations of autoinducer (AI) than the activation by LuxR2. On the other hand, LuxR1 does not require GroEL/ES chaperonin for its folding and cannot be degraded by protease Lon, while LuxR2 sensitive to Lon and requires GroEL/ES. Here we show that at 10(-5) - 10(-4)М concentrations of AI a combination of luxR1 and luxR2 products is capable of activating the Pr-promoters of A. logei lux-operon in Escherichia coli independently of GroEL/ES and protease Lon. The presence of LuxR1 assists LuxR2 in gro(-) cells when AI was added at high concentration, while at low concentration of AI in a cell LuxR1 decreases the LuxR2 activity. These observations may be explained by the formation of LuxR1/LuxR2 heterodimers that act in complex with AI independently from GroEL/ES and protease Lon. This study expands current understanding of QS regulation in A. logei as it implies cooperative regulation of lux-operon by LuxR1 and LuxR2 proteins. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. 14 CFR 1274.937 - Security requirements for unclassified information technology resources.

    Science.gov (United States)

    2010-01-01

    ... information technology resources. 1274.937 Section 1274.937 Aeronautics and Space NATIONAL AERONAUTICS AND... Conditions § 1274.937 Security requirements for unclassified information technology resources. Security Requirements for Unclassified Information Technology Resources July 2002 (a) The Recipient shall be responsible...

  12. Learning R for geospatial analysis

    CERN Document Server

    Dorman, Michael

    2014-01-01

    This book is intended for anyone who wants to learn how to efficiently analyze geospatial data with R, including GIS analysts, researchers, educators, and students who work with spatial data and who are interested in expanding their capabilities through programming. The book assumes familiarity with the basic geographic information concepts (such as spatial coordinates), but no prior experience with R and/or programming is required. By focusing on R exclusively, you will not need to depend on any external software-a working installation of R is all that is necessary to begin.

  13. System requirements for a computerised patient record information system at a busy primary health care clinic

    Directory of Open Access Journals (Sweden)

    PJ Blignaut

    2001-09-01

    Full Text Available A prototyping approach was used to determine the essential system requirements of a computerised patient record information system for a typical township primary health care clinic. A pilot clinic was identified and the existing manual system and business processes in this clinic was studied intensively before the first prototype was implemented. Interviews with users, incidental observations and analysis of actual data entered were used as primary techniques to refine the prototype system iteratively until a system with an acceptable data set and adequate functionalities were in place. Several non-functional and user-related requirements were also discovered during the prototyping period.

  14. Requirements for a Global Greenhouse Gas Information System

    Science.gov (United States)

    Duren, R.; Boland, S.; Lempert, R.; Miller, C.

    2008-12-01

    A global greenhouse gas information system will prove a critical component of any successful effort to mitigate climate change which relies on limiting the atmospheric concentration of greenhouse gases. The system will provide the situational awareness necessary to actively reduce emissions, influence land use change, and sequester carbon. The information from such a system will be subject to intense scrutiny. Therefore, an effective system must openly and transparently produce data of unassailable quality. A global greenhouse gas information system will likely require a combination of space-and air-based remote- sensing assets, ground-based measurements, carbon cycle modeling and self-reporting. The specific requirements on such a system will be shaped by the degree of international cooperation it enjoys and the needs of the policy regime it aims to support, which might range from verifying treaty obligations, to certifying the tradable permits and offsets underlying a market in greenhouse gas emission reductions, to providing a comprehensive inventory of high and low emitters that could be used by non-governmental organizations and other international actors. While some technical studies have examined particular system components in single scenarios, there remains a need for a comprehensive survey of the range of potential requirements, options, and strategies for the overall system. We have initiated such a survey and recently hosted a workshop which engaged a diverse community of stakeholders to begin synthesizing requirements for such a system, with an initial focus on carbon dioxide. In this paper we describe our plan for completing the definition of the requirements, options, and strategies for a global greenhouse gas monitoring system. We discuss our overall approach and provide a status on the initial requirements synthesis activity.

  15. R and D of seismic emergency information transmission system

    International Nuclear Information System (INIS)

    Ebisawa, Katsumi; Kuno, Tetsuya; Shibata, Katsuyuki; Abe, Ichiro; Tuzuki, Kazuhisa

    2002-01-01

    The R and D Seismic Emergency Information Transmission System has been conducted involving the latest progress in earthquake engineering with regard to estimation techniques on the hypocenter, fault and earthquake motion parameters and in information technologies. This system is the disaster management system which consists of user site and disaster information center and is capable of mutual information transmission through Inter-Net and walkie-talkie. The concept of the disaster management system which is adaptable with DiMSIS (Disaster Management Spatial Information System) developed by professor Kameda et al. of Kyoto University has been established. Based on this concept, a prototype system has been developed. This system has following functions, (1) compatible application both in usual condition and emergency time, (2) the decentralized independence, and (3) the integration of space and time information. The system can estimate the earthquake motion information with 500 m square mesh in a local area and transmit in a few minutes. In the development of the system, seismometer network, surface soil database and amplification functions were prepared for the examination of system function. Demonstration against the Tokai area was carried out and the function was verified. (author)

  16. N2R vs. DR Network Infrastructure Evaluation

    DEFF Research Database (Denmark)

    Pedersen, Jens Myrup; Roost, Lars Jessen; Toft, Per Nesager

    2007-01-01

    Recent development of Internet-based services has set higher requirements to network infrastructures in terms of more bandwidth, lower delays and more reliability. Theoretical research within the area of Structural Quality of Service (SQoS) has introduced a new type of infrastructure which meet...... these requirements: N2R infrastructures. This paper contributes to the ongoing research with a case study from North Jutland. An evaluation of three N2R infrastructures compared to a Double Ring (DR) infrastructure will provide valuable information of the practical applicability of N2R infrastructures. In order...... to study if N2R infrastructures perform better than the DR infrastructure, a distribution network was established based on geographical information system (GIS) data. Nodes were placed with respect to demographic and geographical factors. The established distribution network was investigated with respect...

  17. Putting User Stories First: Experiences Adapting the Legacy Data Models and Information Architecture at NASA JPL's PO.DAAC to Accommodate the New Information Lifecycle Required by SWOT

    Science.gov (United States)

    McGibbney, L. J.; Hausman, J.; Laurencelle, J. C.; Toaz, R., Jr.; McAuley, J.; Freeborn, D. J.; Stoner, C.

    2016-12-01

    The Surface Water & Ocean Topography (SWOT) mission brings together two communities focused on a better understanding of the world's oceans and its terrestrial surface waters. U.S. and French oceanographers and hydrologists and international partners have joined forces to develop this new space mission. At NASA JPL's PO.DAAC, the team is currently engaged in the gathering of SWOT User Stores (access patterns, metadata requirements, primary and value added product requirements, data access protocols, etc.) to better inform the adaptive planning of what will be known as the next generation PO.DAAC Information Architecture (IA). The IA effort acknowledges that missions such as SWOT (and NISAR) have few or no precedent in terms of data volume, hot and cold storage, archival, analysis, existing system engineering complexities, etc. and that the only way we can better understand the projected impacts of such requirements is to interface directly with the User Community. Additionally, it also acknowledges that collective learning has taken place to understand certain limitations in the existing data models (DM) underlying the existing PO.DAAC Data Management and Archival System. This work documents an evolutionary, use case based, standards driven approach to adapting the legacy DM and accompanying knowledge representation infrastructure at NASA JPL's PO.DAAC to address forthcoming DAAC mission requirements presented by missions such as SWOT. Some of the topics covered in this evolution include, but are not limited to: How we are leveraging lessons learned from the development of existing DM (such as that generated for SMAP) in an attempt to map them to SWOT. What is the governance model for the SWOT IA? What are the `governing' entities? What is the hierarchy of the `governed entities'? How are elements grouped? How is the design-working group formed? How is model independence maintained and what choices/requirements do we have for the implementation language? The use of

  18. At R807

    CERN Multimedia

    1978-01-01

    Preparation of one half of the central detector for the Axial-Field Spectrometer (AFS) to be used by the Brookhaven-CERN-Copenhagen-Lund-Rutherford Lab.-Tel Aviv Collaboration. The experiment R807 was intended to study large transverse momentum phenomena by selecting either a single particle at large angle, identified by a set of Čerenkov counters, or events with large transverse energy, recorded in the calorimeter. See Annual Report 1979 p. 69 .

  19. Seaway Information System Management and Control Requirements

    Science.gov (United States)

    1973-10-01

    This report examines in detail the control and information system requirements of the St. Lawrence Seaway development program in terms of the needs of the vessel traffic controllers and the management users. Structural control models of Seaway operat...

  20. R and D in control, instrumentation, and electronic systems at CRNL

    International Nuclear Information System (INIS)

    Moeck, E.O.; Stirling, A.J.; Yan, G.

    1980-10-01

    Research and development in control, instrumentation, and electronics is part of the refinement of the CANDU power plant design and of the R and D work at the Chalk River Nuclear Laboratories. The programs presently being carried out in these areas are described in this report. Many of these projects originated in response to a potential for performance improvements in CANDU power plants and are aimed at extending plant capabilities and applying new technology and ideas to achieve better and less expensive systems. Some of these projects such as the development of in-reactor pressure transducers for fuel testing are to be completed in a matter of months. Others, for example heavy water vapor loss instruments, will have gone through the laboratory development phase within a year or two. More sophisicated developments such as multivariable controllers, computer-based safety systems, and advanced neutron detectors will continue over 4 or 5 years. This time scale also applies to the design and implementation of new control and safety systems for the NRU research reactor. Still others will require more than 5 years to be fully operational. New systems for the detection and location of failed fuel and a total information network with distributed intelligence, to be applied to future power stations, fall into that category. (auth)

  1. On Setting Day-Ahead Equity Trading Risk Limits: VaR Prediction at Market Close or Open?

    Directory of Open Access Journals (Sweden)

    Ana-Maria Fuertes

    2016-09-01

    Full Text Available This paper investigates the information content of the ex post overnight return for one-day-ahead equity Value-at-Risk (VaR forecasting. To do so, we deploy a univariate VaR modeling approach that constructs the forecast at market open and, accordingly, exploits the available overnight close-to-open price variation. The benchmark is the bivariate VaR modeling approach proposed by Ahoniemi et al. that constructs the forecast at the market close instead and, accordingly, it models separately the daytime and overnight return processes and their covariance. For a small cap portfolio, the bivariate VaR approach affords superior predictive ability than the ex post overnight VaR approach whereas for a large cap portfolio the results are reversed. The contrast indicates that price discovery at the market open is less efficient for small capitalization, thinly traded stocks.

  2. Freight advanced traveler information system : functional requirements.

    Science.gov (United States)

    2012-08-01

    This report describes the System Requirement Specifications (SyRS) for a Freight Advanced Traveler Information System : (FRATIS). The SyRS is based on user needs described in the FRATIS Concept of Operations (ConOps), which cover the essential : func...

  3. 3D GEO-INFORMATION REQUIREMENTS FOR DISASTER AND EMERGENCY MANAGEMENT

    Directory of Open Access Journals (Sweden)

    E. Demir Ozbek

    2016-06-01

    Full Text Available A conceptual approach is proposed to define 3D geo-information requirement for different types of disasters. This approach includes components such as Disaster Type-Sector-Actor-Process-Activity-Task-Data. According to disaster types processes, activities, tasks, sectors, and responsible and operational actors are derived. Based on the tasks, the needed level of detail for 3D geo-information model is determined. The levels of detail are compliant with the 3D international standard CityGML. After a brief introduction on the disaster phases and geo-information requirement for actors to perform the tasks, the paper discusses the current situation of disaster and emergency management in Turkey and elaborates on components of conceptual approach. This paper discusses the 3D geo-information requirements for the tasks to be used in the framework of 3D geo-information model for Disaster and Emergency Management System in Turkey. The framework is demonstrated for an industrial fire case in Turkey.

  4. Export Control Requirements for Tritium Processing Design and R&D

    Energy Technology Data Exchange (ETDEWEB)

    Hollis, William Kirk [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Maynard, Sarah-Jane Wadsworth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-04-05

    This document will address requirements of export control associated with tritium plant design and processes. Los Alamos National Laboratory has been working in the area of tritium plant system design and research and development (R&D) since the early 1970’s at the Tritium Systems Test Assembly (TSTA). This work has continued to the current date with projects associated with the ITER project and other Office of Science Fusion Energy Science (OS-FES) funded programs. ITER is currently the highest funding area for the DOE OS-FES. Although export control issues have been integrated into these projects in the past a general guidance document has not been available for reference in this area. To address concerns with currently funded tritium plant programs and assist future projects for FES, this document will identify the key reference documents and specific sections within related to tritium research. Guidance as to the application of these sections will be discussed with specific detail to publications and work with foreign nationals.

  5. Export Control Requirements for Tritium Processing Design and R&D

    Energy Technology Data Exchange (ETDEWEB)

    Hollis, William Kirk [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Maynard, Sarah-Jane Wadsworth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-10-30

    This document will address requirements of export control associated with tritium plant design and processes. Los Alamos National Laboratory has been working in the area of tritium plant system design and research and development (R&D) since the early 1970’s at the Tritium Systems Test Assembly (TSTA). This work has continued to the current date with projects associated with the ITER project and other Office of Science Fusion Energy Science (OS-FES) funded programs. ITER is currently the highest funding area for the DOE OS-FES. Although export control issues have been integrated into these projects in the past a general guidance document has not been available for reference in this area. To address concerns with currently funded tritium plant programs and assist future projects for FES, this document will identify the key reference documents and specific sections within related to tritium research. Guidance as to the application of these sections will be discussed with specific detail to publications and work with foreign nationals.

  6. Event-related rTMS at encoding affects differently deep and shallow memory traces.

    Science.gov (United States)

    Innocenti, Iglis; Giovannelli, Fabio; Cincotta, Massimo; Feurra, Matteo; Polizzotto, Nicola R; Bianco, Giovanni; Cappa, Stefano F; Rossi, Simone

    2010-10-15

    The "level of processing" effect is a classical finding of the experimental psychology of memory. Actually, the depth of information processing at encoding predicts the accuracy of the subsequent episodic memory performance. When the incoming stimuli are analyzed in terms of their meaning (semantic, or deep, encoding), the memory performance is superior with respect to the case in which the same stimuli are analyzed in terms of their perceptual features (shallow encoding). As suggested by previous neuroimaging studies and by some preliminary findings with transcranial magnetic stimulation (TMS), the left prefrontal cortex may play a role in semantic processing requiring the allocation of working memory resources. However, it still remains unclear whether deep and shallow encoding share or not the same cortical networks, as well as how these networks contribute to the "level of processing" effect. To investigate the brain areas casually involved in this phenomenon, we applied event-related repetitive TMS (rTMS) during deep (semantic) and shallow (perceptual) encoding of words. Retrieval was subsequently tested without rTMS interference. RTMS applied to the left dorsolateral prefrontal cortex (DLPFC) abolished the beneficial effect of deep encoding on memory performance, both in terms of accuracy (decrease) and reaction times (increase). Neither accuracy nor reaction times were instead affected by rTMS to the right DLPFC or to an additional control site excluded by the memory process (vertex). The fact that online measures of semantic processing at encoding were unaffected suggests that the detrimental effect on memory performance for semantically encoded items took place in the subsequent consolidation phase. These results highlight the specific causal role of the left DLPFC among the wide left-lateralized cortical network engaged by long-term memory, suggesting that it probably represents a crucial node responsible for the improved memory performance induced by

  7. Federal R and D Reductions, Market Share, and Aerospace Information Usage

    Science.gov (United States)

    Rocker, JoAnne; Roncaglia, George

    2000-01-01

    Reductions in federally funded research have a rippling effect over the entire aerospace industry. The decline in federal R&D spending in aerospace in recent years coincides with declines in U.S. aerospace market share, One of the lesser-understood factors in the declining U.S. market share may be the differing ways and intensity with which the U.S. and its competitors approach another trend, the increasing availability of large amounts of aerospace research information on the World Wide Web. The U.S. has been a pioneer in making research information available in electronic form, and the international community has long been a heavy consumer of that information. In essence, the U.S. contributes to the research efforts of its competitors, thus contributing to foreign aerospace consortiums efforts to gain market share in the aerospace industry, This may be a cautionary note to the U.S. aerospace industry to consider the use of R&D output in its own development and strategy because the foreign competition is using the U.S. scientific and technical literature.

  8. At R607

    CERN Multimedia

    CERN PhotoLab

    1979-01-01

    This experiment by the Amsterdam-Louvain-North Western Collaboration measured the correlations between mesons produced with high longitudinal momentum. It was installed at the ISR intersection I-6 following the removal of the 'lamp shade' and septum magnets of R606. The photo shows one of the two small-angle spectrometers, each consistimg of a septum magnet, 5 drift chamber modules, 2 Cerenkov counters and two scintillator hodoscopes. Lars Leistam sits on top of the magnet.

  9. Formalization of software requirements for information systems using fuzzy logic

    Science.gov (United States)

    Yegorov, Y. S.; Milov, V. R.; Kvasov, A. S.; Sorokoumova, S. N.; Suvorova, O. V.

    2018-05-01

    The paper considers an approach to the design of information systems based on flexible software development methodologies. The possibility of improving the management of the life cycle of information systems by assessing the functional relationship between requirements and business objectives is described. An approach is proposed to establish the relationship between the degree of achievement of business objectives and the fulfillment of requirements for the projected information system. It describes solutions that allow one to formalize the process of formation of functional and non-functional requirements with the help of fuzzy logic apparatus. The form of the objective function is formed on the basis of expert knowledge and is specified via learning from very small data set.

  10. Clinical information system post-adoption evaluation at the georges pompidou university hospital.

    Science.gov (United States)

    Palm, Jean-Marc; Dart, Thierry; Dupuis, Isabelle; Leneveut, Laurence; Degoulet, Patrice

    2010-11-13

    The evaluation of a clinical information system (CIS) at different stages of deployment and routine use is a key factor to improve acceptability and use by health professionals. This paper examines on an expectation-confirmation model (ITPAM) the relationships between the determinants of success of a CIS in a cross-sectional survey performed at the Georges Pompidou University Hospital (HEGP). Results for the groups of physicians and nurses that replied to the survey (n=312) suggest that health professional satisfaction (overall R(2)=0.60) is determined by the quality of user support (r=.21, p=<0001), ease of use (r=.19, p=<0001), confirmation of expectations (r=.15, p=.0037), usefulness (r=.12, p=.0068), and compatibility (r=.10, p=.0206). The best predictor of physician satisfaction (R(2)=0.71) was compatibility (r=.21, p=.0072) whereas for nurses (R(2)=0.52) it was user support (r=.22, p=<0001) and ease of use (r=.22, p=.0001). Confirmation of expectations had an impact on post-adoption expectation and user's satisfaction, and confirms its importance for CIS evaluation studies.

  11. ACCOUNTING INFORMATION SYSTEM - QUALITATIVE CHARACTERISTICS AND THE IMPORTANCE OF ACCOUNTING INFORMATION AT TRADE ENTITIES

    Directory of Open Access Journals (Sweden)

    CARAIMAN ADRIAN-COSMIN

    2015-03-01

    Full Text Available Financial and accounting information systems, today, no longer are the traditional ones, they are subject to the normalisation and harmonisation, in the idea of globalization, and as a natural consequence of this situation, the users of accounting information require more and more diverse information from these systems. The economic entities in general, and those in the trade, in particular, performance management, management of the current situation, with multiple phenomena of crisis, require substantiation of decisions on the basis of a system of real information, pertinent, relevant and provided in a timely manner (Radu, 2011 [7]. Apart from users and goals of information provided by entities of the accounting information system of trade entities, they must have certain qualitative characteristics that facilitate the process of interpretation and use of accounting information. At the same time they are needed because their accounting information through its better goal, to represent the support base for the elaboration of certain decisions by those interested. In this article I propose to introduce qualitative characteristics of accounting information provided by IASB (International Accounting Standards Board, which, incidentally, have been taken up initially by the Romanian accounting regulations, with their subsequent amendments and additions, so far, because, in the end, as a conclusion, I consider that I should be noted that these qualities cannot be effective unlessin turn, the users themselves have the quality to have the knowledge required to understand the information that is intended for them.

  12. The Conserved RNA Exonuclease Rexo5 Is Required for 3′ End Maturation of 28S rRNA, 5S rRNA, and snoRNAs

    Directory of Open Access Journals (Sweden)

    Stefanie Gerstberger

    2017-10-01

    Full Text Available Non-coding RNA biogenesis in higher eukaryotes has not been fully characterized. Here, we studied the Drosophila melanogaster Rexo5 (CG8368 protein, a metazoan-specific member of the DEDDh 3′-5′ single-stranded RNA exonucleases, by genetic, biochemical, and RNA-sequencing approaches. Rexo5 is required for small nucleolar RNA (snoRNA and rRNA biogenesis and is essential in D. melanogaster. Loss-of-function mutants accumulate improperly 3′ end-trimmed 28S rRNA, 5S rRNA, and snoRNA precursors in vivo. Rexo5 is ubiquitously expressed at low levels in somatic metazoan cells but extremely elevated in male and female germ cells. Loss of Rexo5 leads to increased nucleolar size, genomic instability, defective ribosome subunit export, and larval death. Loss of germline expression compromises gonadal growth and meiotic entry during germline development.

  13. Modeling traceability information and functionality requirement in export-oriented tilapia chain.

    Science.gov (United States)

    Zhang, Xiaoshuan; Feng, Jianying; Xu, Mark; Hu, Jinyou

    2011-05-01

    Tilapia has been named as the 'food fish of the 21st century' and has become the most important farmed fish. China is the world leader in tilapia production and export. Identifying information and functional requirements is critical in developing an efficient traceability system because traceability has become a fundamental prerequisite for exporting aquaculture products. This paper examines the export-oriented tilapia chains and information flow in the chains, and identifies the key actors, information requirements and information-capturing points. Unified Modeling Language (UML) technology is adopted to describe the information and functionality requirement for chain traceability. The barriers of traceability system adoption are also identified. The results show that the traceability data consist of four categories that must be recorded by each link in the chain. The functionality requirement is classified into four categories from the fundamental information record to decisive quality control; the top three barriers to the traceability system adoption are: high costs of implementing the system, lack of experienced and professional staff; and low level of government involvement and support. Copyright © 2011 Society of Chemical Industry.

  14. An analytical approach to customer requirement information processing

    Science.gov (United States)

    Zhou, Zude; Xiao, Zheng; Liu, Quan; Ai, Qingsong

    2013-11-01

    'Customer requirements' (CRs) management is a key component of customer relationship management (CRM). By processing customer-focused information, CRs management plays an important role in enterprise systems (ESs). Although two main CRs analysis methods, quality function deployment (QFD) and Kano model, have been applied to many fields by many enterprises in the past several decades, the limitations such as complex processes and operations make them unsuitable for online businesses among small- and medium-sized enterprises (SMEs). Currently, most SMEs do not have the resources to implement QFD or Kano model. In this article, we propose a method named customer requirement information (CRI), which provides a simpler and easier way for SMEs to run CRs analysis. The proposed method analyses CRs from the perspective of information and applies mathematical methods to the analysis process. A detailed description of CRI's acquisition, classification and processing is provided.

  15. Forecasting Value-at-Risk Using High-Frequency Information

    Directory of Open Access Journals (Sweden)

    Huiyu Huang

    2013-06-01

    Full Text Available in the prediction of quantiles of daily Standard&Poor’s 500 (S&P 500 returns we consider how to use high-frequency 5-minute data. We examine methods that incorporate the high frequency information either indirectly, through combining forecasts (using forecasts generated from returns sampled at different intraday interval, or directly, through combining high frequency information into one model. We consider subsample averaging, bootstrap averaging, forecast averaging methods for the indirect case, and factor models with principal component approach, for both direct and indirect cases. We show that in forecasting the daily S&P 500 index return quantile (Value-at-Risk or VaR is simply the negative of it, using high-frequency information is beneficial, often substantially and particularly so, in forecasting downside risk. Our empirical results show that the averaging methods (subsample averaging, bootstrap averaging, forecast averaging, which serve as different ways of forming the ensemble average from using high-frequency intraday information, provide an excellent forecasting performance compared to using just low-frequency daily information.

  16. Solid Waste Information and Tracking System (SWITS) Software Requirements Specification

    International Nuclear Information System (INIS)

    MAY, D.L.

    2000-01-01

    This document is the primary document establishing requirements for the Solid Waste Information and Tracking System (SWITS) as it is converted to a client-server architecture. The purpose is to provide the customer and the performing organizations with the requirements for the SWITS in the new environment. This Software Requirement Specification (SRS) describes the system requirements for the SWITS Project, and follows the PHMC Engineering Requirements, HNF-PRO-1819, and Computer Software Qualify Assurance Requirements, HNF-PRO-309, policies. This SRS includes sections on general description, specific requirements, references, appendices, and index. The SWITS system defined in this document stores information about the solid waste inventory on the Hanford site. Waste is tracked as it is generated, analyzed, shipped, stored, and treated. In addition to inventory reports a number of reports for regulatory agencies are produced

  17. Solid Waste Information and Tracking System (SWITS) Software Requirements Specification

    Energy Technology Data Exchange (ETDEWEB)

    MAY, D.L.

    2000-03-22

    This document is the primary document establishing requirements for the Solid Waste Information and Tracking System (SWITS) as it is converted to a client-server architecture. The purpose is to provide the customer and the performing organizations with the requirements for the SWITS in the new environment. This Software Requirement Specification (SRS) describes the system requirements for the SWITS Project, and follows the PHMC Engineering Requirements, HNF-PRO-1819, and Computer Software Qualify Assurance Requirements, HNF-PRO-309, policies. This SRS includes sections on general description, specific requirements, references, appendices, and index. The SWITS system defined in this document stores information about the solid waste inventory on the Hanford site. Waste is tracked as it is generated, analyzed, shipped, stored, and treated. In addition to inventory reports a number of reports for regulatory agencies are produced.

  18. 76 FR 65504 - Proposed Agency Information Collection

    Science.gov (United States)

    2011-10-21

    ..., 888 First Street, NE., Washington, DC 20426. FOR FURTHER INFORMATION CONTACT: Ellen Brown may be...-1 and 009-1 FAC-009-1 R1 Generator owners......... None, this requirement Retention period is derived from R1 of increased by 2 years. FAC-008-1. R2 Generator owners......... None, this requirement...

  19. [The practice of development and implementation of quality management systems in medical laboratories. The GOST R ISO 15189-2009 "medical laboratories. The detailed requirements to quality and competence". Particular difficulties of global nature].

    Science.gov (United States)

    Emanuel', A V; Ivanov, G A; Fleganova, I N; Emanuel', V L

    2012-12-01

    The article discusses the methodological issues related to the implementation of international principles of standardization in the format of GOST R ISO 9001-2008 "Quality management systems. Requirements", GOST R ISO 15189-2009 "Medical laboratories. The detailed requirements to quality and competence" and GOST R ISO 18113.1-5 "Medical items for diagnostics in vitro. Information provided by manufacturer (marking)". This approach legibly assigns the responsibility concerning the support of metrological correctness of laboratory measurements. The lacking of both full-value public and sectorial normative documentation and coordinated positions of Rosstandard and Minzdrav of Russia on functioning of medical laboratories is noted.

  20. VaR and CVaR Implied in Option Prices

    Directory of Open Access Journals (Sweden)

    Giovanni Barone Adesi

    2016-02-01

    Full Text Available VaR (Value at Risk and CVaR (Conditional Value at Risk are implied by option prices. Their relationships to option prices are derived initially under the pricing measure. It does not require assumptions about the distribution of portfolio returns. The effects of changes of measure are modest at the short horizons typically used in applications. The computation of CVaR from option price is very convenient, because this measure is not elicitable, making direct comparisons of statistical inferences from market data problematic.

  1. An overview of what is required and when for developing a beamline at the ALS

    International Nuclear Information System (INIS)

    Hussain, Z.

    1995-08-01

    This report discusses these topics: reviews required for developing a beamline at the ALS; work items and documentation required for the beamline design review; information to be communicated to the ALS staff before the beamline readiness review; work items and documentation required for the beamline readiness review; contacts for information, technical questions, and sources of additional information; and checklist of what is required and when for developing a beamline

  2. Four Reference Models for Transparency Requirements in Information Systems

    OpenAIRE

    Hosseini, Mahmoud; Shahri, Alimohammad; Phalp, Keith T.; Ali, Ra

    2017-01-01

    Transparency is a key emerging requirement in modern businesses and their information systems. Transparency refers to the information which flows amongst stakeholders for the purpose of informed decision-making and taking the right action. Transparency is generally associated with positive connotations such as trust and accountability. However, it has been shown that it could have adverse effects such as information overload and affecting decisions objectiveness. This calls for systematic app...

  3. Information security management handbook, v.7

    CERN Document Server

    O'Hanley, Richard

    2013-01-01

    Updated annually, the Information Security Management Handbook, Sixth Edition, Volume 7 is the most comprehensive and up-to-date reference available on information security and assurance. Bringing together the knowledge, skills, techniques, and tools required of IT security professionals, it facilitates the up-to-date understanding required to stay one step ahead of evolving threats, standards, and regulations. Reporting on the latest developments in information security and recent changes to the (ISC)2(R) CISSP Common Body of Knowledge (CBK(R)), this volume features 27 new chapters on topics

  4. Proposed rulemaking to risk-inform special treatment requirements

    International Nuclear Information System (INIS)

    Reed, Timothy A.; McKenna, Eileen M.

    2003-01-01

    This paper presents the status of Nuclear Regulatory Commission (NRC) rulemaking efforts to risk-inform special treatment requirements that reside in Title 10 of the Code of Federal Regulations, 10 CFR Part 21, Part 50, and Part 100. The staff has prepared a proposed rulemaking to add a new section to 10 CFR Part 50 to provide an alternative set of requirements for treatment of structures, systems and components (SSCs), using a risk-informed categorization process to determine safety significance of the SSCs. These requirements can be voluntarily adopted by light-water reactor licensees and applicants. The proposed rule is based upon extensive interactions with stakeholders (including consideration of public comments on draft rule language made available on the NRC rulemaking web site), experience with pilot plants, and guidance development activities. The NRC staff expects that stakeholder input provided in response to the proposed rule issuance will be valuable and support the efforts to issue the final rule. (author)

  5. R-Hadron Search at ATLAS

    DEFF Research Database (Denmark)

    Heisterkamp, Simon Johann Franz

    In this thesis I motivate and present a search for long lived massive R-hadrons using the data collected by the ATLAS detector in 2011. Both ionisation- and time-of-ight-based methods are described. Since no signal was found, a lower limit on the mass of such particles is set. The analysis was also...... published by the ATLAS collboration in Phys.Lett.B. titled `Searches for heavy long-lived sleptons and R-Hadrons with the ATLAS detector in pp collisions at sqrt(s) = 7 TeV'....

  6. Technological Cooperation Networks at Bio-Manguinhos: the Role of Information and Communication Technologies

    Directory of Open Access Journals (Sweden)

    Lázaro Pereira de Oliveira

    2015-01-01

    Full Text Available This article identifies and discusses the contribution of information and communication technologies (ICTs to the technological cooperation projects of Bio-Manguinhos, a pharmaceutical manufacturer that belongs to Osvaldo Cruz Foundation (FIOCRUZ, responsible for producing vaccines, reagents and biopharmaceuticals, with priority on meeting the needs of the Brazilian public health system. It is a case study with a qualitative approach for descriptive and explanatory purposes. The data were collected from 14 interviews conducted with managers of research and development (R&D projects with high relevance to the organization. The results allow concluding that the ICTs requiring greater interdependence between partners and two-way knowledge flows have not yet been used. They also show the importance of closer cooperation between the information technology (IT and R&D areas. A future positioning of Bio-Manguinhos as a technological center focused on discovery and sale of new active ingredients can favor the use of tools that promote greater integration between the partners of technology cooperation networks.

  7. 48 CFR 1804.470 - Security requirements for unclassified information technology (IT) resources.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Security requirements for unclassified information technology (IT) resources. 1804.470 Section 1804.470 Federal Acquisition Regulations... Classified Information Within Industry 1804.470 Security requirements for unclassified information technology...

  8. Report on the results of `the R and D of industrial technology information base arrangement`; `Sangyo gijutsu joho kiban seibi kenkyu kaihatsu` seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    In relation to information processing in the open type research information networking, R and D were conducted to establish basic technologies such as grading-up, acceleration, enhancement of efficiency, diversification of application, promotion of usable data accumulation, etc. As to the R and D of software to promote sharing of research information, software was developed which can easily modify and renew management objects for users at research sites, etc., and the target was almost achieved. Concerning the R and D of information supply technology, an approach was presented whereby clients submit bids for each stream of the data requested and the admission decision is made so as to maximize gain of the session under network capacity constraints. Additionally, the R and D were made of software to construct an international information sharing system, a system for multi-lingual I/O, text manipulation and communication, and software for remote use of network based information for scientific computing. 138 refs., 125 figs., 33 tabs.

  9. 75 FR 43166 - Information Collection; Central Contractor Registration Requirements for Prime Grant Recipients

    Science.gov (United States)

    2010-07-23

    ...] Information Collection; Central Contractor Registration Requirements for Prime Grant Recipients AGENCY: Office... information collection requirement regarding Central Contractor Registration Requirements for Prime Grant... for the proper performance of functions of the Central Contractor Registration Requirements for Prime...

  10. Information Requirements Specification II: Brainstorming Collective Decision-Making Technique.

    Science.gov (United States)

    Telem, Moshe

    1988-01-01

    Information requirements specification (IRS) constitutes an Achilles heel in the system life cycle of management information systems. This article establishes a systematic overall IRS technique applicable to organizations of all types and sizes. The technique's integration of brainstorming and theory Z principles creates an effective, stimulating,…

  11. 26 CFR 1.857-9 - Information required in returns of shareholders.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Information required in returns of shareholders. 1.857-9 Section 1.857-9 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Real Estate Investment Trusts § 1.857-9 Information required...

  12. Functional enhancement of AT1R potency in the presence of the TPαR is revealed by a comprehensive 7TM receptor co-expression screen.

    Directory of Open Access Journals (Sweden)

    Jonas Tind Hansen

    Full Text Available BACKGROUND: Functional cross-talk between seven transmembrane (7TM receptors can dramatically alter their pharmacological properties, both in vitro and in vivo. This represents an opportunity for the development of novel therapeutics that potentially target more specific biological effects while causing fewer adverse events. Although several studies convincingly have established the existence of 7TM receptor cross-talk, little is known about the frequencey and biological significance of this phenomenon. METHODOLOGY/PRINCIPAL FINDINGS: To evaluate the extent of synergism in 7TM receptor signaling, we took a comprehensive approach and co-expressed 123 different 7TM receptors together with the angiotensin II type 1 receptor (AT1R and analyzed how each receptor affected the angiotensin II (AngII response. To monitor the effect we used integrative receptor activation/signaling assay called Receptor Selection and Amplification Technology (R-SAT. In this screen the thromboxane A2α receptor (TPαR was the only receptor which significantly enhanced the AngII-mediated response. The TPαR-mediated enhancement of AngII signaling was significantly reduced when a signaling deficient receptor mutant (TPαR R130V was co-expressed instead of the wild-type TPαR, and was completely blocked both by TPαR antagonists and COX inhibitors inhibiting formation of thromboxane A2 (TXA2. CONCLUSIONS/SIGNIFICANCE: We found a functional enhancement of AT1R only when co-expressed with TPαR, but not with 122 other 7TM receptors. In addition, the TPαR must be functionally active, indicating the AT1R enhancement is mediated by a paracrine mechanism. Since we only found one receptor enhancing AT1R potency, our results suggest that functional augmentation through 7TM receptor cross-talk is a rare event that may require specific conditions to occur.

  13. 25 CFR 215.17 - Additional information required.

    Science.gov (United States)

    2010-04-01

    ... interested in lead and zinc mining leases, or land under the jurisdiction of the Quapaw Indian Agency, and... 25 Indians 1 2010-04-01 2010-04-01 false Additional information required. 215.17 Section 215.17 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEAD AND ZINC MINING...

  14. 77 FR 58817 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement (DFARS...

    Science.gov (United States)

    2012-09-24

    ... automated collection techniques or other forms of information technology. The Office of Management and... 252.232-7002, Progress Payments for Foreign Military Sales Acquisitions; OMB Control Number 0704-0321.... The clause at 252.232- 7002, Progress Payments for Foreign Military Sales Acquisitions, requires each...

  15. Risk-informing special treatment requirements for reactors

    International Nuclear Information System (INIS)

    McKenna, E.M.; Reed, T.A.

    2001-01-01

    The U.S. Nuclear Regulatory Commission (NRC) is proposing to make regulatory changes to the scope of structures, systems, and components (SSCs) requiring special treatment. ''Special treatment requirements'' refers to those specific examples of regulations that are applied in order to provide a high degree of assurance that SSC will be capable of performing their intended functions when needed. The current scope of SSCs covered by the special treatment requirements governing commercial nuclear reactors is deterministically based and stems primarily from the evaluation of selected design basis events, as described in updated final safety analysis reports (UFSARs). This regulatory framework provides reasonable assurance of no undue risk to the health and safety of the public. However, recent advances in technology, coupled with operating reactor experience, have suggested that an alternative approach that would use a risk-informed process for evaluating SSC safety significance, would, in turn, result in a more focused determination of which SSCs should receive special treatment requirements. (author)

  16. Information management and technology strategy in healthcare: local timescales and national requirements

    Directory of Open Access Journals (Sweden)

    Les Smith

    2000-01-01

    Full Text Available The UK National Health Service’s strategic switch-back is well documented and each centrally originated change results in various attempts to record the repercussions and predict the outcomes. The most recent shift is embodied in the Department of Health’s information strategy, Information for health published in September 1998. This document provides the context for an examination of the issue of developing an Information Management and Technology (IM&T strategy at the local level within the changing national requirements for NHS information management. The particular pressures on an individual unit and the need to react to them alongside the requirements of the national strategy are the subjects of this article. The case detailed is that of Clatterbridge Centre for Oncology (CCO on Merseyside, the second largest centre of its type in the UK. Its initial investigation of information needs preceded the publication of the national strategy and its implementation straddled the timescale devised by the NHS Information Authority. The inevitable incompatibility between timescales for the local and the national developments is examined within the case. The work of the new NHS Information Authority and its supporting guidance in its Circular, Information for Health: Initial Local Implementation Strategies, is evaluated as a tool in aligning local and national strategy. Information Managers in other centrally governed organisations within the public sector and large corporations are often alert to similar issues.

  17. A non-randomised controlled trial of the R&R2MHP cognitive skills program in high risk male offenders with severe mental illness.

    Science.gov (United States)

    C-Y Yip, Vivienne; Gudjonsson, Gisli H; Perkins, Derek; Doidge, Amie; Hopkin, Gareth; Young, Susan

    2013-10-18

    The growing popularity of offending behavior programs has led to the interest of whether such programs are effective with mentally disordered offenders. This study aimed to evaluate the effectiveness of the Reasoning and Rehabilitation program adapted for offenders with severe mental illness (R&R2 MHP). A sample of 59 adult high risk males detained in a high secure hospital completed questionnaires at baseline and post treatment to assess violent attitudes, anger, coping processes and social problem-solving. An informant measure of social and psychological functioning, including disruptive behavior, was completed by staff at the same time. The data of 30 patients who participated in the group condition were compared using intention to treat analysis with 29 controls who received treatment as usual. 80% of group participants completed the program. In contrast to controls, significant medium-large treatment effects were found at outcome on self-reported measures of violent attitudes, social problem-solving and coping processes. Improvements were endorsed by informant ratings of disruptive behavior, social and psychological functioning. The R&R2MHP had a comparatively low dropout rate and was effective in a sample of high risk mentally disordered offenders requiring detention in high security. Future research should use a randomized controlled design. Current Controlled Trials ACTRN12613000216718.

  18. Intelligence and Information-Sharing Elements of S.4 and H.R. 1

    National Research Council Canada - National Science Library

    Masse, Todd

    2007-01-01

    Title I of S.4 and Title VII of H.R. 1 include corresponding measures related to enhancing information and intelligence sharing, both horizontally within the Federal Government and vertically between the Federal Government and state...

  19. Distinct regions in the C-Terminus required for GLP-1R cell surface expression, activity and internalisation.

    Science.gov (United States)

    Thompson, Aiysha; Kanamarlapudi, Venkateswarlu

    2015-09-15

    The glucagon-like peptide-1 (GLP-1) receptor (GLP-1R), an important drug target in the treatment of type 2 diabetes, is a G-protein coupled receptor (GPCR) that mediates insulin secretion by GLP-1. The N-terminus controls GLP-1R biosynthetic trafficking to the cell surface but the C-terminus involvement in that trafficking is unknown. The aim of this study was to identify distinct regions within the C-terminal domain required for human GLP-1R (hGLP-1R) cell surface expression, activity and internalisation using a number of C-terminal deletions and site-directed mutations. The results of this study revealed that the residues 411-418 within the C-terminal domain of the hGLP-1R are critical in targeting the newly synthesised receptor to the plasma membrane. The residues 419-430 are important for cAMP producing activity of the receptor, most likely by coupling to Gαs. However, the residues 431-450 within the C-terminus are essential for agonist-induced hGLP-1R internalisation. In conclusion, these findings demonstrate the hGLP-1R has distinct regions within the C-terminal domain required for its cell surface expression, activity and agonist-induced internalisation. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  20. Implications of ITER requirements on R and D of RF heating and current drive systems

    International Nuclear Information System (INIS)

    Bosia, G.

    2002-01-01

    A strategic, rather than auxiliary role is assigned to H and CD systems in ITER-FEAT, as all operation phases are driven and controlled by heating and current drive (H and CD) systems. RF systems (Electron Cyclotron, Ion Cyclotron and Lower Hybrid), planned to contribute for ∼60% of ITER auxiliary power (72 MW), still require different level of pre-industrial technology development to operate in ITER at the required level of efficiency and religiosite. In this paper, RF H and CD systems technical and operational issues are reviewed and future R and D actions at CEA-Cadarache discussed, with the aim of providing a demonstration of all RF H and CD systems, within the current ITER construction time scale. The need and the economical advantage of an early on- and off- plasma design validation program for ITER-like RF devices (such as launcher and/or power sources), is also discussed with the aim of identifying and resolving operational issues. (author)

  1. Construction Operations Building Information Exchange (COBIE): Requirements Definition and Pilot Implementation Standard

    Science.gov (United States)

    2007-06-01

    Swalley U.S. Department of State, Overseas Buildings Operations Toby Wilson U.S. Army, Corps of Engineers, Engineer R&D Center Jeff Wix AEC3 The...exchanged in COBIE. To map those information exchanges to the IFC model, the Information Delivery Manual (IDM) process [ Wix 2007] was also used. The...Folksonomy. Wikimedia Foundation. http://en.wikipedia.org/wiki/Folksonomy/, accessed 3 August 2007. Wix , Jeffrey. 2007. Information Delivery Manual

  2. RSEIS and RFOC: Seismic Analysis in R

    Science.gov (United States)

    Lees, J. M.

    2015-12-01

    Open software is essential for reproducible scientific exchange. R-packages provide a platform for development of seismological investigation software that can be properly documented and traced for data processing. A suite of R packages designed for a wide range of seismic analysis is currently available in the free software platform called R. R is a software platform based on the S-language developed at Bell Labs decades ago. Routines in R can be run as standalone function calls, or developed in object-oriented mode. R comes with a base set of routines, and thousands of user developed packages. The packages developed at UNC include subroutines and interactive codes for processing seismic data, analyzing geographic information (GIS) and inverting data involved in a variety of geophysical applications. On CRAN (Comprehensive R Archive Network, http://www.r-project.org/) currently available packages related to seismic analysis are RSEIS, Rquake, GEOmap, RFOC, zoeppritz, RTOMO, and geophys, Rwave, PEIP, hht, rFDSN. These include signal processing, data management, mapping, earthquake location, deconvolution, focal mechanisms, wavelet transforms, Hilbert-Huang Transforms, tomographic inversion, and Mogi deformation among other useful functionality. All software in R packages is required to have detailed documentation, making the exchange and modification of existing software easy. In this presentation, I will focus on packages RSEIS and RFOC, showing examples from a variety of seismic analyses. The R approach has similarities to the popular (and expensive) MATLAB platform, although R is open source and free to down load.

  3. Qualities and Requirements of the Financial – Accounting Information

    OpenAIRE

    Boghean Cristina Iuliana

    2011-01-01

    Accounting information is used in most of the decision-making processes of a company; therefore measuring its quality has become a matter of present interest. The quality of information largely determines the performances of the financial – accounting department, as well as the successful reaching of the company’s goals. Any reflection on the concept of quality in accountancy requires prior clarification of the purpose corresponding to the relation between the accounting information, its user...

  4. Development of safeguards information treatment system at the facility level

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Byung Doo; Song, Dae Yong; So, Dong Sup; Kwack, Eun Ho [Korea Atomic Energy Research Institute, Taejeon (Korea)

    2000-04-01

    Safeguards Information Treatment System(SITS) at the facility level is required to implement efficiently the obligations under the Korea-IAEA Safeguards Agreement, bilateral agreements with other countries and domestic law. In this report, the requirements and major functions of SITS were considered, and the error checking methods and the relationships of safeguards information were reviewed. SITS will be developed to cover the different accounting procedures and methods applied at the various facilities under IAEA safeguards. Also, the resolved result of the Y2K problem in the existing nuclear material accounting program was described. 3 tabs. (Author)

  5. 78 FR 68830 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Service...

    Science.gov (United States)

    2013-11-15

    ... or other forms of information technology. The Office of Management and Budget (OMB) has approved this... Services. The provision at DFARS 252.237- 7024 requires offerors to submit with its offer a written plan describing how it will continue to perform essential contractor services during periods of crisis. The...

  6. 75 FR 30861 - Proposed Extension of the Approval of Information Collection Requirements

    Science.gov (United States)

    2010-06-02

    ... industrial homework as necessary to prevent circumvention or evasion of the minimum wage requirements of the... at not less than 85 percent of the applicable minimum wage or less than $1.60, whichever is higher... DEPARTMENT OF LABOR Wage and Hour Division Proposed Extension of the Approval of Information...

  7. XocR, a LuxR solo required for virulence in Xanthomonas oryzae pv. oryzicola.

    Science.gov (United States)

    Xu, Huiyong; Zhao, Yancun; Qian, Guoliang; Liu, Fengquan

    2015-01-01

    Xanthomonas oryzae pv. oryzicola (Xoc) causes bacterial leaf streak (BLS) in rice, a serious bacterial disease of rice in Asia and parts of Africa. The virulence mechanisms of Xoc are not entirely clear and control measures for BLS are poorly developed. The solo LuxR proteins are widespread and shown to be involved in virulence in some plant associated bacteria (PAB). Here, we have cloned and characterized a PAB LuxR solo from Xoc, named as XocR. Mutation of xocR almost completely impaired the virulence ability of Xoc on host rice, but did not alter the ability to trigger HR (hypersensitive response, a programmed cell death) on non-host (plant) tobacco, suggesting the diversity of function of xocR in host and non-host plants. We also provide evidence to show that xocR is involved in the regulation of growth-independent cell motility in response to a yet-to-be-identified rice signal, as mutation of xocR impaired cell swimming motility of wild-type Rs105 in the presence but not absence of rice macerate. We further found that xocR regulated the transcription of two characterized virulence-associated genes (recN and trpE) in the presence of rice macerate. The promoter regions of recN and trpE possessed a potential binding motif (an imperfect pip box-like element) of XocR, raising the possibility that XocR might directly bind the promoter regions of these two genes to regulate their transcriptional activity. Our studies add a new member of PAB LuxR solos and also provide new insights into the role of PAB LuxR solo in the virulence of Xanthomonas species.

  8. Le rôle de l'information en droit des entreprises en difficulté

    OpenAIRE

    Ould Eba, Moussa

    2013-01-01

    L’information est un moyen de gestion fiable et une garantie indispensable pour la protection des intérêts des acteurs de l’activité économique. Elle joue un rôle important dans la prévention et le traitement des difficultés des entreprises. En effet, à la lumière des informations comptables, financières et sociales, les dirigeants peuvent prévenir les difficultés et prendre les décisions adaptées à la situation de l’entreprise. Toutefois, en cas de procédures collectives, le besoin de protec...

  9. 75 FR 6683 - Notice of Proposed Information Collection: Comment Request; Technical Processing Requirements for...

    Science.gov (United States)

    2010-02-10

    ... Information Collection: Comment Request; Technical Processing Requirements for Multifamily Project Mortgage... information: Title of Proposal: Technical Processing Requirements for Multifamily Project Mortgage Insurance... information collection requirement described below will be submitted to the Office of Management and Budget...

  10. Data manipulation with R

    CERN Document Server

    Abedin, Jaynal

    2014-01-01

    This book is a step-by step, example-oriented tutorial that will show both intermediate and advanced users how data manipulation is facilitated smoothly using R.This book is aimed at intermediate to advanced level users of R who want to perform data manipulation with R, and those who want to clean and aggregate data effectively. Readers are expected to have at least an introductory knowledge of R and some basic administration work in R, such as installing packages and calling them when required.

  11. NLM Evidence-based Information at Your Fingertips - NBNA

    Energy Technology Data Exchange (ETDEWEB)

    Womble, R.

    2010-08-06

    The workshop titled, National Library of Medicine: Evidence-based Information At Your Fingertips, is a computer training class designed to meet the needs of nurses who require access to information on specific medical topics and on the adverse health effects of exposure to hazardous substances. The Specialized Information Services Division of the National Library of Medicine (NLM) is sponsoring this workshop for the National Black Nurses Association to increase the awareness of health professionals of the availability and value of the free NLM medical, environmental health, and toxicology databases.

  12. A Look at Informal Logic

    Directory of Open Access Journals (Sweden)

    Iryna Khomenko

    2018-04-01

    Full Text Available The challenges of the global time require new solutions and up-to-date ways of thinking and communication. These challenges call for the ability to use critical thinking to face the ever-changing world and the ability to maintain a dialog based on the effective skills of communication. Studies in the fields of logic and argumentation theory are of particular importance in this regard. Nowadays they can be presented as a mix of theoretical and practical approaches. In this paper, I will present my reflections on informal logic, which was formed in the late 1970s. Unfortunately, in spite of numerous papers, books, and text-books published over the last forty years, consensus on many issues in this field has not been achieved so far. Therefore, it is difficult to treat informal logic as one of the well-defined approaches to argumentation. The goal of this paper is to take a look at the place of informal logic in state-of-the art study of argumentation by clarifying its subject matter and figuring out the realm to which informal logic belongs.

  13. At R802

    CERN Multimedia

    1974-01-01

    The photo shows the magnet (blue) of the spectrometer covering nearly the complete solid angle used by the CERN-Rome Collaboration to study negative particles at angles close to 0 deg with respect to one of the two colliding beams (Annual Report 1974, p. 108 and Photo Archive 7402246). Particles were identified by four threshold Cerenkov counters (on the left, bottom) and their trajectories were determined by twelve planes of MWPC (multiwire proportional chambers). The angular correlations between these particles and the over-all distribution of charged secondaries as observed in the hodoscope of R801 were also determined. On the centre a surveyor.

  14. Users’ Information Requirements and Narrative Reporting: The Case of Iranian Companies

    Directory of Open Access Journals (Sweden)

    Bikram Chatterjee

    2010-06-01

    Full Text Available This paper investigates whether the narrative section of Iranian companies’ annual reports satisfies theinformation requirements of financial analysts employed by institutional investors. Taking a group ofstakeholders (i.e. financial analysts as the sample, a questionnaire survey was conducted to identify their topthree information needs from the narrative sections of company annual reports in each of three informationcategories: Present, Analytical and Prospective. Following this survey, a checklist was prepared to analysewhether Iranian companies are disclosing this information required by financial analysts. Overall, the resultspartially support stakeholder theory as there is a general lack of information flow on the part of Iranian listedcompanies in meeting their stakeholders’ information needs.

  15. 17 CFR 230.481 - Information required in prospectuses.

    Science.gov (United States)

    2010-04-01

    ... GENERAL RULES AND REGULATIONS, SECURITIES ACT OF 1933 Investment Companies; Business Development Companies... Delivery Obligation Until (insert date), all dealers that effect transactions in these securities, whether... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Information required in...

  16. Chairman's report. Report on the IEA round table on information exchange and co-operation in R and D

    International Nuclear Information System (INIS)

    Doucet, G.

    1997-01-01

    In contrast to the parallel Workshops, the Round Table was designed to stimulate simultaneous discussion among panelists and interaction with the audience. The task of the Round Table and Information Exchange and Co-operation in R and D was to answer six key questions: what are then more recent prospects or opportunities for natural gas utilisation which justify major commitments to information exchange and R and D? How have government social or economic goals affected funding for R and D in North America, Europe and Asia? Is the move to energy service and, in some key markets, deregulation forcing natural gas companies to reassess private commitments to R and D? How well do natural gas companies or centres of excellence around the world exchange information and promote technology transfer compared with coal and electricity interests? What is the future role of governments, universities, laboratories and international agencies like IEA to eliminate duplication and to foster funding partnerships? Are there useful models of information exchange using state-of-the-art electronic data which optimise linkages among key production and consumption markets? (R.P.)

  17. Report on Workshop on Future Directions for Accelerator R&D at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Shiltsev, V.; Church, M.; Spentzouris, P.; Chou, W.; /Fermilab

    2009-09-01

    Accelerator R&D has played a crucial role in enabling scientific discovery in the past century and will continue to play this role in the years to come. In the U.S., the Office of High Energy Physics of DOE's Office of Science is developing a plan for national accelerator R&D stewardship. Fermilab undertakes accelerator research, design, and development focused on superconducting radio-frequency (RF), superconducting magnet, beam cooling, and high intensity proton technologies. In addition, the Lab pursues comprehensive integrated theoretical concepts and simulations of complete future facilities on both the energy and intensity frontiers. At present, Fermilab (1) supplies integrated design concept and technology development for a multi-MW proton source (Project X) to support world-leading programs in long baseline neutrino and rare processes experiments; (2) plays a leading role in the development of ionization cooling technologies required for muon storage ring facilities at the energy (multi-TeV Muon Collider) and intensity (Neutrino Factory) frontiers, and supplies integrated design concepts for these facilities; and (3) carries out a program of advanced accelerator R&D (AARD) in the field of high quality beam sources, and novel beam manipulation techniques.

  18. Open access models of publications: a strategy for improving 3R information retrieval?

    OpenAIRE

    Vullioud-Marcacci, Sylvie

    2013-01-01

    Accessing 3R information for fundamental research is difficult for many reasons: the titles, abstracts, and author keywords of scientific articles do not contain the terms 3R, Reduce, Refine, Replace, alternatives or replacement. Mesh terms in Pubmed or thesaurus terms in Embase are rare and are not systematically attributed to scientific articles using animal experimentation or substitution methods. Reporting of animal conditions, animal and cell strains used for fundamental research are oft...

  19. 78 FR 64146 - 30-Day Notice of Proposed Information Collection: Technical Processing Requirements for...

    Science.gov (United States)

    2013-10-25

    ... Information Collection: Technical Processing Requirements for Multifamily Project Mortgage Insurance AGENCY: Office of the Chief Information Officer, HUD. ACTION: Notice. SUMMARY: HUD has submitted the proposed... Information Collection Title of Information Collection: Technical Processing Requirements for Multifamily...

  20. 7 CFR 4290.620 - Requirements to obtain information from Portfolio Concerns.

    Science.gov (United States)

    2010-01-01

    ... English. (a) Information for initial Financing decision. Before extending any Financing, you must require... financing proceeds), cash flow analyses, projections, and such economic development information about the Enterprise, as are necessary to support your investment decision. The information submitted must be...

  1. A.C.R.O. activity report 2000

    International Nuclear Information System (INIS)

    2000-01-01

    Environmental surveillance and public information are translated in 2000 by numerous actions. To improve the public information, A.C.R.O. concerns its main efforts on the development of the consumer technical information available on-line via its web site and in its regular publication 'the nuclear chronicle'. A new publication, the A.C.R.O. journal is made to answer to more acute questions as waste burying. Besides, the participation of the A.C.R.O. at various local commissions of information (C.L.I.) as well as at the superior council of the safety and nuclear information ( C.S.S.I.N.) stays an essential action. (N.C.)

  2. Information carriers and (reading them through) information theory in quantum chemistry.

    Science.gov (United States)

    Geerlings, Paul; Borgoo, Alex

    2011-01-21

    This Perspective discusses the reduction of the electronic wave function via the second-order reduced density matrix to the electron density ρ(r), which is the key ingredient in density functional theory (DFT) as a basic carrier of information. Simplifying further, the 1-normalized density function turns out to contain essentially the same information as ρ(r) and is even of preferred use as an information carrier when discussing the periodic properties along Mendeleev's table where essentially the valence electrons are at stake. The Kullback-Leibler information deficiency turns out to be the most interesting choice to obtain information on the differences in ρ(r) or σ(r) between two systems. To put it otherwise: when looking for the construction of a functional F(AB) = F[ζ(A)(r),ζ(B)(r)] for extracting differences in information from an information carrier ζ(r) (i.e. ρ(r), σ(r)) for two systems A and B the Kullback-Leibler information measure ΔS is a particularly adequate choice. Examples are given, varying from atoms, to molecules and molecular interactions. Quantum similarity of atoms indicates that the shape function based KL information deficiency is the most appropriate tool to retrieve periodicity in the Periodic Table. The dissimilarity of enantiomers for which different information measures are presented at global and local (i.e. molecular and atomic) level leads to an extension of Mezey's holographic density theorem and shows numerical evidence that in a chiral molecule the whole molecule is pervaded by chirality. Finally Kullback-Leibler information profiles are discussed for intra- and intermolecular proton transfer reactions and a simple S(N)2 reaction indicating that the theoretical information profile can be used as a companion to the energy based Hammond postulate to discuss the early or late transition state character of a reaction. All in all this Perspective's answer is positive to the question of whether an even simpler carrier of

  3. Evaluation of information display at advanced main control room

    Energy Technology Data Exchange (ETDEWEB)

    Min, Dae Hwan; Yu, Seon Jae; Choi, Eui Sun [Korea Univ., Seoul (Korea, Republic of)

    2000-03-15

    This year we plan to survey information in order to have basic understanding of digital information display and control at the advanced MCR. At first we collect different ways of presenting information at the advanced MCR. Secondly, we conduct literature survey on studies that have investigated information representation techniques and their effects. Then, we need compare differences between conventional NPPs and advanced NPPs. Thirdly, we need to check HMI styles and evaluation techniques that are used currently at foreign NPPs. Indeed, HMI at the advanced MCR is quite different from that at a conventional MCR. It is not desirable to apply the same evaluation technique that has veen used at the conventional MCR. We need to develop an evaluation technique that is valid in theory and applicable in practice. Finally, we identify the requirements for a support system for an HMI evaluator, since it is not easy to carry out an evaluation task even though one has firm background on cognitive engineering theories and practical experiences.

  4. Evaluation of information display at advanced main control room

    International Nuclear Information System (INIS)

    Min, Dae Hwan; Yu, Seon Jae; Choi, Eui Sun

    2000-03-01

    This year we plan to survey information in order to have basic understanding of digital information display and control at the advanced MCR. At first we collect different ways of presenting information at the advanced MCR. Secondly, we conduct literature survey on studies that have investigated information representation techniques and their effects. Then, we need compare differences between conventional NPPs and advanced NPPs. Thirdly, we need to check HMI styles and evaluation techniques that are used currently at foreign NPPs. Indeed, HMI at the advanced MCR is quite different from that at a conventional MCR. It is not desirable to apply the same evaluation technique that has veen used at the conventional MCR. We need to develop an evaluation technique that is valid in theory and applicable in practice. Finally, we identify the requirements for a support system for an HMI evaluator, since it is not easy to carry out an evaluation task even though one has firm background on cognitive engineering theories and practical experiences

  5. 75 FR 78185 - Information Management Requirements for Derivatives Clearing Organizations

    Science.gov (United States)

    2010-12-15

    ... Principles J, K, L and M. This is based on the Commission's view that rigorous information management... COMMODITY FUTURES TRADING COMMISSION 17 CFR Parts 1, 21, and 39 RIN 3038-AC98 Information Management Requirements for Derivatives Clearing Organizations AGENCY: Commodity Futures Trading Commission...

  6. 50 CFR 85.12 - Information collection, recordkeeping, and reporting requirements.

    Science.gov (United States)

    2010-10-01

    ... VESSEL ACT GRANT PROGRAM General § 85.12 Information collection, recordkeeping, and reporting... CFR 12.80), and financial reporting (43 CFR 12.81). (c) Reporting requirements include retention and... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Information collection, recordkeeping, and...

  7. Current gas storage R and D programmes at Gas Research Institute

    International Nuclear Information System (INIS)

    Shikari, Y.A.

    1990-01-01

    The Gas Research Institute (GRI) is currently involved in the development of concepts aimed at an enhancement of natural gas service to the consumer. In order to maintain the attractiveness of the gas options to industrial consumers and to reinforce the ''value-in-use'' of natural gas to residential as well as commercial customers, it is essential to develop efficient, economical, and safe means of reducing the ''cost-of-service'', including that of natural gas storage in underground formations. Specifically, research and development (R and D) is needed to explore ways to better utilize existing storage fields and also to develop new storage facilities at minimum cost. GRI is currently sponsoring research projects aimed at controlling gas migration in underground gas storage reservoirs, reducing base (or cushion) gas requirements, understanding the gas-gas phase mixing behaviour via laboratory experiments and reservoir models, developing cost-effective gas separation processes using membranes, and optimizing the operation and maintenance (O and M) costs of underground gas storage operations. This paper provides an overview of the GRI's Gas Storage R and D Programme and highlights key results achieved to date for selected research projects. (author). 16 refs, 6 figs, 3 tabs

  8. Quality Requirements for Electronic Health Record Systems*. A Japanese-German Information Management Perspective.

    Science.gov (United States)

    Winter, Alfred; Takabayashi, Katsuhiko; Jahn, Franziska; Kimura, Eizen; Engelbrecht, Rolf; Haux, Reinhold; Honda, Masayuki; Hübner, Ursula H; Inoue, Sozo; Kohl, Christian D; Matsumoto, Takehiro; Matsumura, Yasushi; Miyo, Kengo; Nakashima, Naoki; Prokosch, Hans-Ulrich; Staemmler, Martin

    2017-08-07

    For more than 30 years, there has been close cooperation between Japanese and German scientists with regard to information systems in health care. Collaboration has been formalized by an agreement between the respective scientific associations. Following this agreement, two joint workshops took place to explore the similarities and differences of electronic health record systems (EHRS) against the background of the two national healthcare systems that share many commonalities. To establish a framework and requirements for the quality of EHRS that may also serve as a basis for comparing different EHRS. Donabedian's three dimensions of quality of medical care were adapted to the outcome, process, and structural quality of EHRS and their management. These quality dimensions were proposed before the first workshop of EHRS experts and enriched during the discussions. The Quality Requirements Framework of EHRS (QRF-EHRS) was defined and complemented by requirements for high quality EHRS. The framework integrates three quality dimensions (outcome, process, and structural quality), three layers of information systems (processes and data, applications, and physical tools) and three dimensions of information management (strategic, tactical, and operational information management). Describing and comparing the quality of EHRS is in fact a multidimensional problem as given by the QRF-EHRS framework. This framework will be utilized to compare Japanese and German EHRS, notably those that were presented at the second workshop.

  9. IMPORTANT INFORMATION - Flagstaff Car-Park and Park-and-Ride (P+R)

    CERN Document Server

    GS Department

    2011-01-01

    As part of the new arrangements following the arrival of the tram-line at CERN, an Automatic Number-Plate Recognition (ANPR) system has been installed restricting access to the Flagstaff Car-park and the Park-and-Ride (P+R) zone according to the conditions set out below: Holders of a valid P+R user card may enter the car-park at all hours but may only park in the area specifically designated as the P+R zone. P+R user cards can be purchased from the Fondation des Parkings de Genève (http://www.ge.ch/parkings/abonnements.html)   Members of CERN personnel and of contractors' personnel, whatever their status, may freely access the Flagstaff Car-Park at all hours, as long as their vehicle is duly registered with CERN, but they may not use the P+R zone, which is reserved for holders of P+R user cards. Please check that your vehicle number-plates are properly registered via AdaMS (http://cern.ch/adams). If this is not the case, the following action must be taken: - for private or co...

  10. UIS BW environmental information system Baden-Wuerttemberg. R+D project INOVUM. Innovative environmental information systems. Phase I 2014/16

    International Nuclear Information System (INIS)

    Weissenbach, Kurt; Schillinger, Wolfgang; Weidemann, Rainer

    2016-01-01

    The R and D project INOVUM of the Ministry for the Environment, Climate and Energy Baden-Wuerttemberg relies on a wide cooperation with partners from government, science and industry to jointly develop governmental environmental information systems. In the focus of this project phase were, e.g. a revision of the framework concept for the Environmental Information System Baden-Wuerttemberg, service-based applications, the development of environmental portals, mobile applications and map services.

  11. POSSIBLE ORIGIN OF RHIC R OUT/R SID HBT RESULTS

    International Nuclear Information System (INIS)

    PADULA, S.S.

    2002-01-01

    The effects of opacity of the nuclei together with a blackbody type of emission along the system history are considered as a means to explain the ratio R out /R sid observed by STAR and PHENIX collaborations at RHIC. Within our model, no flow is required to explain the data trend of this ratio for large surface emissivities

  12. POSSIBLE ORIGIN OF RHIC R OUT / R SID HBT RESULTS

    International Nuclear Information System (INIS)

    PADULA, S.

    2002-01-01

    The effects of opacity of the nuclei together with a blackbody type of emission along the system history are considered as a means to explain the ratio R out /R sid observed by STAR and PHENIX collaborations at RHIC. Within our model, no flow is required to explain the data trend of this ratio for large surface emissivities

  13. Changing R&D models in research-based pharmaceutical companies

    OpenAIRE

    Schuhmacher, Alexander; Gassmann, Oliver; Hinder, Markus

    2016-01-01

    New drugs serving unmet medical needs are one of the key value drivers of research-based pharmaceutical companies. The efficiency of research and development (R&D), defined as the successful approval and launch of new medicines (output) in the rate of the monetary investments required for R&D (input), has declined since decades. We aimed to identify, analyze and describe the factors that impact the R&D efficiency. Based on publicly available information, we reviewed the R&D models of major re...

  14. Analysis of R-R intervals in patients with atrial fibrillation at rest and during exercise

    NARCIS (Netherlands)

    Bootsma, B.K.; Hoelen, A.J.; Strackee, J.; Meijler, F.L.

    Serial autocorrelation functions and histograms of R-R intervals in patients with atrial fibrillation, with and without digitalis, at rest and during exercise, were produced by a computer. At rest with and without digitalis the first and higher order coefficients did not differ from zero. During

  15. Requirements to be made on future information systems in NPP operation

    International Nuclear Information System (INIS)

    Becker, G.; Distler, K.

    1987-01-01

    The objective of advanced operational information systems (OIS) is to support and alleviate the operator's work. Human skills and performance limits on the one hand, and the tasks of the operators during various operating states on the other hand are the bases for deriving system design requirements. The paper discusses such aspects like the dynamism of process events, the passive/active role played by the operators in normal/disturbed operation, the compatibility of information representation between OIS and conventional display configuration, parallel versus serial information presentation, team work of operators, parallel processing of tasks within the team; the resulting requirements are derived. (orig./DG) [de

  16. A comparative study and analysis of QA requirements for the establishment of a nuclear R and D QA system

    International Nuclear Information System (INIS)

    Kim, Kwan Hyun

    2000-06-01

    This technical report provides recommendations on how to fulfill the requirements of the code in relation to QA activities for nuclear R and D field. This guide applies to the quality assurance (QA) programmes of the responsible organization, i.e. the organization having overall responsibility for the nuclear power plant, as well as to any other separate QA programmes in each stage of a nuclear R and D project. This guide covers QA work on items, services and processes impacting nuclear safety during siting, design, construction, commissioning, operation and decommissioning of nuclear power plants. The impact on safety may occur during the performance of the QA work, or owing to the application of the results of the QA. This guide may, with appropriate modification, also be usefully applied at nuclear installations other than nuclear R and D field

  17. compendiumdb: an R package for retrieval and storage of functional genomics data.

    Science.gov (United States)

    Nandal, Umesh K; van Kampen, Antoine H C; Moerland, Perry D

    2016-09-15

    Currently, the Gene Expression Omnibus (GEO) contains public data of over 1 million samples from more than 40 000 microarray-based functional genomics experiments. This provides a rich source of information for novel biological discoveries. However, unlocking this potential often requires retrieving and storing a large number of expression profiles from a wide range of different studies and platforms. The compendiumdb R package provides an environment for downloading functional genomics data from GEO, parsing the information into a local or remote database and interacting with the database using dedicated R functions, thus enabling seamless integration with other tools available in R/Bioconductor. The compendiumdb package is written in R, MySQL and Perl. Source code and binaries are available from CRAN (http://cran.r-project.org/web/packages/compendiumdb/) for all major platforms (Linux, MS Windows and OS X) under the GPLv3 license. p.d.moerland@amc.uva.nl Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  18. 78 FR 79455 - Information Collection; System for Award Management Registration Requirements for Prime Grant...

    Science.gov (United States)

    2013-12-30

    ...] Information Collection; System for Award Management Registration Requirements for Prime Grant Recipients.... ADDRESSES: Submit comments identified by Information Collection 3090- 0290, System for Award Management... ``Information Collection 3090-0290, System for Award Management Registration Requirements for Prime Grant...

  19. Bridging information requirements and information needs assessment: do scenarios and vignettes provide a link?

    Directory of Open Access Journals (Sweden)

    Christine Urquhart

    2001-01-01

    Full Text Available The aim of the paper is to compare the philosophies of the vignette and critical incident techniques in information behaviour research, with the methodologies used in object oriented analysis such as use case scenarios and CRC (class, responsibility, collaboration cards. The principles of object oriented analysis are outlined, noting the emphasis on obtaining the "storyline" or "scripts" for information requirements analysis through use cases and CRC cards.  The critical incident technique and vignettes are used to obtain valid interpretations of users" information behaviour, using a storyline approach for data collection (and analysis which is similar to that of object oriented analysis. Some examples illustrate how techniques developed in object oriented analysis could be used for data display in information behaviour studies. Concludes that the methods developed by software engineering could be adapted usefully for information behaviour research.

  20. The R Commander: A Basic-Statistics Graphical User Interface to R

    Directory of Open Access Journals (Sweden)

    John Fox

    2005-08-01

    Full Text Available Unlike S-PLUS, R does not incorporate a statistical graphical user interface (GUI, but it does include tools for building GUIs. Based on the tcltk package (which furnishes an interface to the Tcl/Tk GUI toolkit, the Rcmdr package provides a basic-statistics graphical user interface to R called the "R Commander." The design objectives of the R Commander were as follows: to support, through an easy-to-use, extensible, cross-platform GUI, the statistical functionality required for a basic-statistics course (though its current functionality has grown to include support for linear and generalized-linear models, and other more advanced features; to make it relatively difficult to do unreasonable things; and to render visible the relationship between choices made in the GUI and the R commands that they generate. The R Commander uses a simple and familiar menu/dialog-box interface. Top-level menus include File, Edit, Data, Statistics, Graphs, Models, Distributions, Tools, and Help, with the complete menu tree given in the paper. Each dialog box includes a Help button, which leads to a relevant help page. Menu and dialog-box selections generate R commands, which are recorded in a script window and are echoed, along with output, to an output window. The script window also provides the ability to edit, enter, and re-execute commands. Error messages, warnings, and some other information appear in a separate messages window. Data sets in the R Commander are simply R data frames, and can be read from attached packages or imported from files. Although several data frames may reside in memory, only one is "active" at any given time. There may also be an active statistical model (e.g., an R lm or glm ob ject. The purpose of this paper is to introduce and describe the use of the R Commander GUI; to describe the design and development of the R Commander; and to explain how the R Commander GUI can be extended. The second part of the paper (following a brief

  1. Usage of information safety requirements in improving tube bending process

    Science.gov (United States)

    Livshitz, I. I.; Kunakov, E.; Lontsikh, P. A.

    2018-05-01

    This article is devoted to an improvement of the technological process's analysis with the information security requirements implementation. The aim of this research is the competition increase analysis in aircraft industry enterprises due to the information technology implementation by the example of the tube bending technological process. The article analyzes tube bending kinds and current technique. In addition, a potential risks analysis in a tube bending technological process is carried out in terms of information security.

  2. BaR-SPOrt: the instrument to be accommodated at Dome C

    Science.gov (United States)

    Zannoni, M.; Carretti, E.; Cortiglioni, S.; Macculi, C.; Ramponi, M.; Sbarra, C.; Ventura, G.; Monari, J.; Poloni, M.; Poppi, S.; Natale, V.; Nesti, R.; Baralis, M.; Peverini, O.; Tascone, R.; Virone, G.; Boscaleri, A.; Boella, G.; Sironi, G.; Gervasi, M.; de Bernardis, P.; Masi, S.; de Petris, M.

    The BaR-SPOrt (Balloon-Borne Radiometers for Sky Polarization Observations) experiment, a program of the Agenzia Spaziale Italiana (ASI) co-funded by PNRA (Progetto Nazionale di Ricerca in Antartide) was originally designed as a payload for long duration balloons flights. The changing scenario, both scientific and strategic, has led us to propose it for the starting winter campaign of at the Concordia Base. Here the instrument and the features making it suitable to operate at Dome-C are described. After the initial setup, BaR-SPOrt should not require any kind of routine intervention by a dedicated base staff. The experiment will just need electrical power (less than 2 kW) and a suitable accommodation on the field. It can be fully monitored and controlled, including the data acquisition, through its own telemetry/telecommand link using IRIDIUM modems. Both the receiver and the critical electronics are housed inside a temperature-controlled vacuum chamber, providing the properly stabilized environment. The cold part of the radiometer employs a closed loop mechanical cryo-cooler that provides temperatures <70 ±0.1 K with low power consumption (<200 W).

  3. A Balanced Approach to Capturing User Requirements in Business- to- Consumer Web Information Systems

    Directory of Open Access Journals (Sweden)

    M. S. Lane

    2001-11-01

    Full Text Available The development of business-to-consumer web information systems pose special challenges in the requirements analysis phase. It is difficult to capture user requirements given that users are relatively autonomous and anonymous and there are no major incentives for users to become involved in the development of a web information system. The researchers reviewed traditional requirement elicitation techniques, marketing research techniques and web usage analysis techniques. Current practice was assessed and the findings suggest that a balanced approach to user requirements capture will result in more complete and user centred requirements. This approach should lead to more effective business-to consumer web information systems.

  4. Liquid facets-related (lqfR is required for egg chamber morphogenesis during Drosophila oogenesis.

    Directory of Open Access Journals (Sweden)

    Peter A Leventis

    Full Text Available Clathrin interactor 1 [CLINT1] (also called enthoprotin/EpsinR is an Epsin N-terminal homology (ENTH domain-containing adaptor protein that functions in anterograde and retrograde clathrin-mediated trafficking between the trans-Golgi network and the endosome. Removal of both Saccharomyces cerevisiae homologs, Ent3p and Ent5p, result in yeast that are viable, but that display a cold-sensitive growth phenotype and mistrafficking of various vacuolar proteins. Similarly, either knock-down or overexpression of vertebrate CLINT1 in cell culture causes mistrafficking of proteins. Here, we have characterized Drosophila CLINT1, liquid-facets Related (lqfR. LqfR is ubiquitously expressed throughout development and is localized to the Golgi and endosome. Strong hypomorphic mutants generated by imprecise P-element excision exhibit extra macrochaetae, rough eyes and are female sterile. Although essentially no eggs are laid, the ovaries do contain late-stage egg chambers that exhibit abnormal morphology. Germline clones reveal that LqfR expression in the somatic follicle cells is sufficient to rescue the oogenesis defects. Clones of mutant lqfR follicle cells have a decreased cell size consistent with a downregulation of Akt1. We find that while total Akt1 levels are increased there is also a significant decrease in activated phosphorylated Akt1. Taken together, these results show that LqfR function is required to regulate follicle cell size and signaling during Drosophila oogenesis.

  5. 76 FR 35218 - Federal Acquisition Regulation; Information Collection; Cost or Pricing Data Requirements and...

    Science.gov (United States)

    2011-06-16

    ... Pricing Data, by any of the following methods: Regulations.gov : http://www.regulations.gov . Submit...; Information Collection; Cost or Pricing Data Requirements and Information Other Than Cost or Pricing Data... concerning cost or pricing data requirements and information other than cost or pricing data. Public comments...

  6. Recognition and categorization considerations for information assurance requirements development and speficication

    Science.gov (United States)

    Stytz, Martin R.; May, Michael; Banks, Sheila B.

    2009-04-01

    Department of Defense (DoD) Information Technology (IT) systems operate in an environment different from the commercial world, the differences arise from the differences in the types of attacks, the interdependencies between DoD software systems, and the reliance upon commercial software to provide basic capabilities. The challenge that we face is determining how to specify the information assurance requirements for a system without requiring changes to the commercial software and in light of the interdependencies between systems. As a result of the interdependencies and interconnections between systems introduced by the global information grid (GIG), an assessment of the IA requirements for a system must consider three facets of a system's IA capabilities: 1) the IA vulnerabilities of the system, 2) the ability of a system to repel IA attacks, and 3) the ability of a system to insure that any IA attack that penetrates the system is contained within the system and does not spread. Each facet should be assessed independently and the requirements should be derived independently from the assessments. In addition to the desired IA technology capabilities of the system, a complete assessment of the system's overall IA security technology readiness level cannot be accomplished without an assessment of the capabilities required of the system for its capability to recover from and remediate IA vulnerabilities and compromises. To allow us to accomplish these three formidable tasks, we propose a general system architecture designed to separate the system's IA capabilities from its other capability requirements; thereby allowing the IA capabilities to be developed and assessed separately from the other system capabilities. The architecture also enables independent requirements specification, implementation, assessment, measurement, and improvement of a system's IA capabilities without requiring modification of the underlying application software.

  7. Status of vertex and tracking detector R&D at CLIC

    CERN Document Server

    AUTHOR|(SzGeCERN)754272

    2015-01-01

    The physics aims at the future CLIC high-energy linear e+e- collider set very high precision requirements on the performance of the vertex and tracking detectors. Moreover, these detectors have to be well adapted to the experimental conditions, such as the bunch train structure of the beam and the presence of beam-induced backgrounds. The principal challenges are: a point resolution of a few micron, ultra-low mass (~0.2% X0 per layer for the inner vertex region), very low power dissipation (compatible with air-flow cooling in the inner vertex region) and pulsed power operation, complemented with ~10 ns time stamping capabilities. An overview of the R&D program for pixel and tracking detectors at CLIC will be presented, including recent results on an innovative hybridisation concept based on capacitive coupling between active sensors (HV-CMOS) and readout ASICs (CLICpix).

  8. 48 CFR 1252.239-70 - Security requirements for unclassified information technology resources.

    Science.gov (United States)

    2010-10-01

    ... unclassified information technology resources. 1252.239-70 Section 1252.239-70 Federal Acquisition Regulations... of Provisions and Clauses 1252.239-70 Security requirements for unclassified information technology... Unclassified Information Technology Resources (APR 2005) (a) The Contractor shall be responsible for...

  9. UTILITY ADVANCED TURBINE SYSTEMS (ATS) TECHNOLOGY READINESS TESTING PHASE 3 RESTRUCTURED (3R)

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    2000-03-17

    This scope document defines the work scope for accomplishing the design of the GE MS7001H and MS9001H (7H and 9H) combined-cycle power systems under the original ATS Phase 3 DOE Cooperative Agreement No. DE-FC21-95MC31176, and incorporates changes in scope required to convert Phase 3 to the ''restructured'' Phase 3R as defined in Amendment A012 to the Cooperative Agreement.

  10. Information management systems for integrating the technical data and regulatory requirements of environmental restoration activities

    International Nuclear Information System (INIS)

    Geffen, C.A.; Garrett, B.A.; Walter, M.B.

    1990-03-01

    Current environmental regulations require that comprehensive planning be conducted before remediating a hazardous waste site to characterize the nature and extent of site contamination, calculate the risk to the public, and assess the effectiveness of various remediation technologies. Remediation of Department of Energy (DOE) sites contaminated with hazardous or mixed wastes will require the effective integration of scientific and engineering data with regulatory and institutional requirements. The information management challenge presented by waste site cleanup activities goes beyond merely dealing with the large quantity of data that will be generated. The information must be stored, managed, and presented in a way that provides some consistency in approach across sites, avoids duplication of effort, and facilitates responses to requests for information from the regulators and the public. This paper provides background information on the regulatory requirements for data gathering and analysis for environmental restoration activities, and outlines the data and information management requirements for completing the pre-remediation phases of an environmental restoration project. Information management systems for integrating the regulatory and institutional requirements of the environmental restoration process with the technical data and analysis requirements are also described. 7 refs

  11. 48 CFR 215.403-3 - Requiring information other than cost or pricing data.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Requiring information other than cost or pricing data. 215.403-3 Section 215.403-3 Federal Acquisition Regulations System... CONTRACTING BY NEGOTIATION Contract Pricing 215.403-3 Requiring information other than cost or pricing data...

  12. Roles and Delegation of Authority (R/DA) System; TOPICAL

    International Nuclear Information System (INIS)

    ABBOTT, JOHN P.; HUTCHINS, JAMES C.; SCHOCH, DAVID G.

    1999-01-01

    The processes of defining managerial roles and providing for delegation of authority are essential to any enterprise. At most large organizations, these processes are defined in policy manuals and through sets of standard operating procedures for many, if not all, business and administrative functions. Many of these staff-initiated, administrative functions require the routing of documents for approval to one or more levels of management. These employee-oriented, back office types of workflows tend to require more flexibility in determining to whom these documents should go to, while, at the same time, providing the responsible parties with the flexibility to delegate their approval authority or allow others to review their work. Although this practice is commonplace in manual, paper-based processes that exist in many organizations, it is difficult to provide the same flexibility in the more structured, electronic-based, workflow systems. The purpose of this report is to present a framework or architecture for creating a R/DA system and provide some insights associated with its design and utilization. To improve understanding and clarify subsequent discussion, the goals and requirements for the major R/DA system components, namely, the database and interface modules, are initially presented along with the identification of important concepts and the definition of critical terms. Next high-level functions relating the types of inputs to the outputs of the R/DA interface module are introduced and discussed. Then the relationships between the major R/DA modules and the primary components associated with its creation and maintenance are presented and analyzed. Finally, some conclusions are drawn relative to the advantages associated with developing a R/DA system for use in implementing an enterprise-wide, work-facilitating information system

  13. 48 CFR 3052.204-70 - Security requirements for unclassified information technology resources.

    Science.gov (United States)

    2010-10-01

    ... unclassified information technology resources. 3052.204-70 Section 3052.204-70 Federal Acquisition Regulations... for unclassified information technology resources. As prescribed in (HSAR) 48 CFR 3004.470-3, insert a clause substantially the same as follows: Security Requirements for Unclassified Information Technology...

  14. 13 CFR 108.620 - Requirements to obtain information from Portfolio Concerns.

    Science.gov (United States)

    2010-01-01

    ... requirements of § 108.600 and must be in English. (a) Information for initial Financing decision. Before extending any Financing, you must require the applicant to submit such financial statements, plans of operation (including intended use of financing proceeds), cash flow analyses, projections, and such...

  15. Information Requirements and Consumer Protection in Future M-Commerce

    DEFF Research Database (Denmark)

    Cleff, Evelyne Beatrix; Henschel, Rene Franz

    2006-01-01

    The aim of this article is to discuss information requirements and consumer protection in mobile commerce. On the basis of a brief introduction to the characteristics of mobile commerce and the regulatory framework that governs mobile commerce in the European Union today, the article presents...

  16. Understanding requirements of novel healthcare information systems for management of advanced prostate cancer.

    Science.gov (United States)

    Wagholikar, Amol S; Fung, Maggie; Nelson, Colleen C

    2012-01-01

    Effective management of chronic diseases is a global health priority. A healthcare information system offers opportunities to address challenges of chronic disease management. However, the requirements of health information systems are often not well understood. The accuracy of requirements has a direct impact on the successful design and implementation of a health information system. Our research describes methods used to understand the requirements of health information systems for advanced prostate cancer management. The research conducted a survey to identify heterogeneous sources of clinical records. Our research showed that the General Practitioner was the common source of patient's clinical records (41%) followed by the Urologist (14%) and other clinicians (14%). Our research describes a method to identify diverse data sources and proposes a novel patient journey browser prototype that integrates disparate data sources.

  17. Evaluation of the Executive Information Requirements for the Market Research Process.

    Science.gov (United States)

    Lanser, Michael A.

    A study examined the marketing research information required by those executives of Lakeshore Technical College (Wisconsin) whose decisions affect the college's direction. Data were gathered from the following sources: literature review; development of a data dictionary framework; analysis of the college's current information system through…

  18. Overview of GNSS-R Research Program for Ocean Observations at Japan

    Science.gov (United States)

    Ichikawa, Kaoru; Ebinuma, Takuji; Akiyama, Hiroaki; Kitazawa, Yukihito

    2015-04-01

    GNSS-R is a new remote-sensing method which uses reflected GNSS signals. Since no transmitters are required, it is suitable for small satellites. Constellations of GNSS-R small satellites have abilities on revolutionary progress on 'all-time observable' remote-sensing methods . We have started a research program for GNSS-R applications on oceanographic observations under a contract with MEXT (Ministry of Education Culture, Sports, Science and Technology, JAPAN) as a'Space science research base formation program'. The duration of research program is 3 years (2015-2017). The one of important focuses of this program is creation of a new community to merge space engineering and marine science through establishment on application plans of GNSS-R. Actual GNSS-R data acquisition experiments using multi-copters, ships, and/or towers are planned, together with in-situ sea truth data such as wave spectrum, wind speed profiles and sea surface height. These data are compared to determine the accuracy and resolution of the estimates based on GNSS-R observations. Meanwhile, preparation of a ground station for receiving GNSS-R satellite data will be also established. Whole those data obtained in this project will be distributed for public. This paper introduces the overview of research plan..

  19. Linking new information to a reactivated memory requires consolidation and not reconsolidation mechanisms.

    Directory of Open Access Journals (Sweden)

    2005-09-01

    Full Text Available A new memory is initially labile and becomes stabilized through a process of consolidation, which depends on gene expression. Stable memories, however, can again become labile if reactivated by recall and require another phase of protein synthesis in order to be maintained. This process is known as reconsolidation. The functional significance of the labile phase of reconsolidation is unknown; one hypothesis proposes that it is required to link new information with reactivated memories. Reconsolidation is distinct from the initial consolidation, and one distinction is that the requirement for specific proteins or general protein synthesis during the two processes occurs in different brain areas. Here, we identified an anatomically distinctive molecular requirement that doubly dissociates consolidation from reconsolidation of an inhibitory avoidance memory. We then used this requirement to investigate whether reconsolidation and consolidation are involved in linking new information with reactivated memories. In contrast to what the hypothesis predicted, we found that reconsolidation does not contribute to the formation of an association between new and reactivated information. Instead, it recruits mechanisms similar to those underlying consolidation of a new memory. Thus, linking new information to a reactivated memory is mediated by consolidation and not reconsolidation mechanisms.

  20. Grand Challenges: Science, Engineering, and Societal Advances, Requiring Networking and Information Technology Research and Development

    Data.gov (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — ...the U.S. Government makes critical decisions about appropriate investments in IT R and D to help society forward both socially and economically. To inform that...

  1. BiplotGUI: Interactive Biplots in R

    Directory of Open Access Journals (Sweden)

    Anthony la Grange

    2009-06-01

    Full Text Available Biplots simultaneously provide information on both the samples and the variables ofa data matrix in two- or three-dimensional representations. The BiplotGUI package provides a graphical user interface for the construction of, interaction with, and manipulation of biplots in R. The samples are represented as points, with coordinates determined either by the choice of biplot, principal coordinate analysis or multidimensional scaling. Various transformations and dissimilarity metrics are available. Information on the original variables is incorporated by linear or non-linear calibrated axes. Goodness-of-t measures are provided. Additional descriptors can be superimposed, including convex hulls, alpha-bags, point densities and classication regions. Amongst the interactive features are dynamic variable value prediction, zooming and point and axis drag-and-drop. Output can easily be exported to the R workspace for further manipulation. Three-dimensional biplots are incorporated via the rgl package. The user requires almost no knowledge of R syntax.

  2. How to make the best of mandatory information requirements in consumer law

    NARCIS (Netherlands)

    Schaub, M.Y.

    2017-01-01

    EU consumer protection relies inter alia on information requirements imposing on traders the duty to provide specific and mandatory information to consumers before the conclusion of a contract. If consumers make well informed choices this can serve their individual interest, but it is also thought

  3. 40 CFR 26.1116 - General requirements for informed consent.

    Science.gov (United States)

    2010-07-01

    ... PROTECTION OF HUMAN SUBJECTS Basic Ethical Requirements for Third-Party Human Research for Pesticides... informed consent. No investigator may involve a human being as a subject in research covered by this... subject's legal rights, or releases or appears to release the investigator, the sponsor, the institution...

  4. miR-191 and miR-135 are required for long-lasting spine remodelling associated with synaptic long-term depression

    Science.gov (United States)

    Hu, Zhonghua; Yu, Danni; Gu, Qin-Hua; Yang, Yanqin; Tu, Kang; Zhu, Jun; Li, Zheng

    2014-02-01

    Activity-dependent modification of dendritic spines, subcellular compartments accommodating postsynaptic specializations in the brain, is an important cellular mechanism for brain development, cognition and synaptic pathology of brain disorders. NMDA receptor-dependent long-term depression (NMDAR-LTD), a prototypic form of synaptic plasticity, is accompanied by prolonged remodelling of spines. The mechanisms underlying long-lasting spine remodelling in NMDAR-LTD, however, are largely unclear. Here we show that LTD induction causes global changes in miRNA transcriptomes affecting many cellular activities. Specifically, we show that expression changes of miR-191 and miR-135 are required for maintenance but not induction of spine restructuring. Moreover, we find that actin depolymerization and AMPA receptor exocytosis are regulated for extended periods of time by miRNAs to support long-lasting spine plasticity. These findings reveal a miRNA-mediated mechanism and a role for AMPA receptor exocytosis in long-lasting spine plasticity, and identify a number of candidate miRNAs involved in LTD.

  5. At R209

    CERN Multimedia

    1977-01-01

    Side view of R209, showing a large muon chamber in front of the Iron toroid magnet. Gunter Feilhauer is looking down from top of the magnet. Ulrich Becker (left), Lars Leistam (right) stand on the floor.

  6. 40 CFR 60.4122 - Information requirements for Hg budget permit applications.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Information requirements for Hg budget... requirements for Hg budget permit applications. A complete Hg Budget permit application shall include the following elements concerning the Hg Budget source for which the application is submitted, in a format...

  7. Status of Land Surface Temperature Product Development at NOAA/NESDIS/STAR for JPSS and GOES-R Missions

    Science.gov (United States)

    Yu, Yunyue; Liu, yuling; yu, peng; Casiszar, Ivan; Zhou, Lihang

    2016-04-01

    Land surface temperature (LST) is of fundamental importance to many aspects of the geosciences, e.g., net radiation budget at the Earth surface, monitoring state of crops and vegetation, as well as an important indicator of both the greenhouse effect and the physics of land-surface processes at local through global scales. Satellite LST measurements provide unique data sources for regional and global coverage in fairly good temporal, spatial resolution and time span. Therefore, LST is one of baseline products in both JPSS and GOES-R satellite missions. The Center for SaTellite Applications and Research (STAR) of NOAA/NESDIS is responsible for developing high quality LST products for a variety of satellite missions including JPSS and GOES-R. The JPSS LST data, which is produced for each swath of observations, has reached its beta, provisional and validated stage 1 status in October 2013, May 2014, and December 2015, respectively. A routine validation and monitoring toolkit has been developed and its results are available through a public web site. Our validation results against the U.S. SURFRAD ground stations show that uncertainty of the VIIRS LST is less than 2.35K (vs. the JPSS mission requirement of 2.5K). Improvement of the JPSS LST product is on-going, which counts surface emissive variation explicitly in retrieval algorithm. Further, a gridded daily global LST product will be available by end of 2016. In terms of the GOES-R LST product, we have evaluated the retrieval algorithm using SEVIRI and AHI data as proxies. The evaluation results show that the accuracy of GOES-R LST is expected to be less than 2.30K (GOES-R mission requirement). The validation toolkit developed for JPSS mission will be extended and applicable for the GOES-R mission as well. A detailed Readiness, Implementation and Management Plan (RIMP) of GOES-R LST beta and provisional validation has been developed for the GOES-R launch that is scheduled in October 2016.

  8. Fiscal Year 2001 Tank Characterization Technical Sampling Basis and Waste Information Requirements Document

    International Nuclear Information System (INIS)

    ADAMS, M.R.

    2000-01-01

    The Fiscal Year 2001 Tank Characterization Technical Sampling Basis and Waste Information Requirements Document (TSB-WIRD) has the following purposes: (1) To identify and integrate sampling and analysis needs for fiscal year (FY) 2001 and beyond. (2) To describe the overall drivers that require characterization information and to document their source. (3) To describe the process for identifying, prioritizing, and weighting issues that require characterization information to resolve. (4) To define the method for determining sampling priorities and to present the sampling priorities on a tank-by-tank basis. (5) To define how the characterization program is going to satisfy the drivers, close issues, and report progress. (6)To describe deliverables and acceptance criteria for characterization deliverables

  9. Similarity of WISC-R and WAIS-R Scores at Age 16.

    Science.gov (United States)

    Sandoval, Jonathan; And Others

    1988-01-01

    Examined similarity of scores of 30 learning disabled students (aged 16 and 17) on the Wechsler Intelligence Scale for Children-Revised (WISC-R) and the Wechsler Adult Intelligence Scale-Revised (WAIS-R). Results documented similarity between WISC-R and WAIS-R for 16 year-olds who were learning disabled and had average intellectual ability.…

  10. Proton-induced knockout reactions with netron-rich oxygen isotopes at R{sup 3}B

    Energy Technology Data Exchange (ETDEWEB)

    Atar, Leyla [IKP, TU Darmstadt (Germany); GSI (Germany); Collaboration: R3B-Collaboration

    2014-07-01

    Proton-induced knockout reactions are one of the main goal of the experimental program at the future R{sup 3}B (Reactions with Relativistic Radioactive Beams) Experiment at FAIR. It allows us to obtain spectroscopic information about valence and deeply bound single-nucleon states and to study their evolution over a large variation in isospin. Recent studies have shown that the occupancies of loosely bound valence nucleons in neutron- or proton-rich nuclei have a spectroscopic factor close to unity, whereas single-particle strength for deeply bound nucleons is suppressed in isospin asymmetric systems compared to the predictions of the many-body shell model. Further experimental and theoretical studies are needed for a qualitative and quantitative understanding. For this aim a series of measurements have been performed on the complete oxygen isotopic chain using the existing experimental setup LAND/R{sup 3}B at GSI. We present the main scientific goals, the concepts of the experiment and the preliminary results.

  11. Applying programmatic risk assessment to nuclear materials stabilization R and D planning

    International Nuclear Information System (INIS)

    Brown-Van Hoozer, S.A.; Kenley, C.R.

    1997-01-01

    A systems engineering approach to programmatic risk assessment, derived from the aerospace industry, was applied to various stabilization technologies to assess their relative maturity and availability for use in stabilizing nuclear materials. The assessment provided valuable information for trading off available technologies and identified the at-risk technologies that will require close tracking by the Department of Energy (DOE) to mitigate programmatic risks. This paper presents the programmatic risk assessment methodology developed for the 1995 R and D Plan and updated for the 1996 R and D Plan. Results of the 1996 assessment also are presented (DOE/ID-10561, 1996)

  12. Functions and requirements document for interim store solidified high-level and transuranic waste

    Energy Technology Data Exchange (ETDEWEB)

    Smith-Fewell, M.A., Westinghouse Hanford

    1996-05-17

    The functions, requirements, interfaces, and architectures contained within the Functions and Requirements (F{ampersand}R) Document are based on the information currently contained within the TWRS Functions and Requirements database. The database also documents the set of technically defensible functions and requirements associated with the solidified waste interim storage mission.The F{ampersand}R Document provides a snapshot in time of the technical baseline for the project. The F{ampersand}R document is the product of functional analysis, requirements allocation and architectural structure definition. The technical baseline described in this document is traceable to the TWRS function 4.2.4.1, Interim Store Solidified Waste, and its related requirements, architecture, and interfaces.

  13. Using task analysis to improve the requirements elicitation in health information system.

    Science.gov (United States)

    Teixeira, Leonor; Ferreira, Carlos; Santos, Beatriz Sousa

    2007-01-01

    This paper describes the application of task analysis within the design process of a Web-based information system for managing clinical information in hemophilia care, in order to improve the requirements elicitation and, consequently, to validate the domain model obtained in a previous phase of the design process (system analysis). The use of task analysis in this case proved to be a practical and efficient way to improve the requirements engineering process by involving users in the design process.

  14. Using simulation and virtual machines to identify information assurance requirements

    Science.gov (United States)

    Banks, Sheila B.; Stytz, Martin R.

    2010-04-01

    The US military is changing its philosophy, approach, and technologies used for warfare. In the process of achieving this vision for high-speed, highly mobile warfare, there are a number of issues that must be addressed and solved; issues that are not addressed by commercial systems because Department of Defense (DoD) Information Technology (IT) systems operate in an environment different from the commercial world. The differences arise from the differences in the scope and skill used in attacks upon DoD systems, the interdependencies between DoD software systems used for network centric warfare (NCW), and the need to rely upon commercial software components in virtually every DoD system. As a result, while NCW promises more effective and efficient means for employing DoD resources, it also increases the vulnerability and allure of DoD systems to cyber attack. A further challenge arises due to the rapid changes in software and information assurance (IA) requirements and technologies over the course of a project. Therefore, the four challenges that must be addressed are determining how to specify the information assurance requirements for a DoD system, minimizing changes to commercial software, incorporation of new system and IA requirements in a timely manner with minimal impact, and insuring that the interdependencies between systems do not result in cyber attack vulnerabilities. In this paper, we address all four issues. In addition to addressing the four challenges outlined above, the interdependencies and interconnections between systems indicate that the IA requirements for a system must consider two important facets of a system's IA defensive capabilities. The facets are the types of IA attacks that the system must repel and the ability of a system to insure that any IA attack that penetrates the system is contained within the system and does not spread. The IA requirements should be derived from threat assessments for the system as well as for the need to

  15. Allocation of R&D Equipment Expenditure Based on Organisation Discipline Profiles

    Science.gov (United States)

    Wells, Xanthe E.; Foster, Nigel; Finch, Adam; Elsum, Ian

    2017-01-01

    Sufficient and state-of-the-art research equipment is one component required to maintain the research competitiveness of a R&D organisation. This paper describes an approach to inform more optimal allocation of equipment expenditure levels in a large and diverse R&D organisation, such as CSIRO. CSIRO is Australia's national science agency,…

  16. Information security fundamentals

    CERN Document Server

    Peltier, Thomas R

    2013-01-01

    Developing an information security program that adheres to the principle of security as a business enabler must be the first step in an enterprise's effort to build an effective security program. Following in the footsteps of its bestselling predecessor, Information Security Fundamentals, Second Edition provides information security professionals with a clear understanding of the fundamentals of security required to address the range of issues they will experience in the field.The book examines the elements of computer security, employee roles and r

  17. 21 CFR 807.87 - Information required in a premarket notification submission.

    Science.gov (United States)

    2010-04-01

    ... § 807.93. (i) A financial certification or disclosure statement or both, as required by part 54 of this... class III under section 513(b) of the act: (1) Which was introduced or delivered for introduction into.... (Information collection requirements in this section were approved by the Office of Management and Budget (OMB...

  18. Review of the effective approaches for providing the R and D information on the geological disposal of HLW

    International Nuclear Information System (INIS)

    Mitsuhashi, Hiroshi; Okuhara, Hidehiko; Nanjo, Yuki

    2001-03-01

    Japan Nuclear Cycle Development Institute (JNC) had already carried out Research and development (R and D) activities for the Geological Disposal of High-level Radioactive Waste (HLW) in Japan, the information activities in order to gain a public understanding in Japan. At present, however, the information on the geological disposal project including R and D is still unpopular among the public and does not draw so much attention compared to the other current topics. To make a national consensus on the project, the effective public relational activities with the suitable approaches for the various groups/classes among the public should be done. From the viewpoint of gaining the social recognition, having the valuable interviews with the authorities, opinion leaders and other specialists, we reviewed the approaches of the effective information activities to gain the public attention and let them have proper understanding. We also had some group interviews subject to the university students and housewives, who are expected to have no concern with the geological disposal. During these interviews, we had monitored the degree of understanding on the geological disposal and JNC's R and D activities utilizing the conventional materials that JNC had already prepared, such as brochures and video tape recording, and found if the materials were helpful or not, for proper understanding. A questionnaire survey on the internet was done, as one of yardsticks for the effect of the JNC's activities. We studied the degree of understanding of the respondents, and analyzed the effect of the JNC's public relational activities. Based on the another questionnaire survey results at 'Forum on geological disposal', which was held by JNC, we also analyzed the effect of the forum as one of two-way communications tools. Following the above analysis, the effective approaches of the future public relational activities of the Geological disposal was reviewed. (author)

  19. Possible origin of RHIC R{sub out}/R{sub sid} HBT results

    Energy Technology Data Exchange (ETDEWEB)

    Padula, Sandra S

    2003-03-10

    The effects of opacity of the nuclei together with a blackbody type of emission along the system history are considered as a means to explain the ratio R{sub out}/R{sub sid} observed by STAR and PHENIX collaborations at RHIC. Within our model, no flow is required to explain the data trend of this ratio for large surface emissivities.

  20. 42 CFR 495.336 - Health information technology planning advance planning document requirements (HIT PAPD).

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Health information technology planning advance... STANDARDS FOR THE ELECTRONIC HEALTH RECORD TECHNOLOGY INCENTIVE PROGRAM Requirements Specific to the Medicaid Program § 495.336 Health information technology planning advance planning document requirements...

  1. Study on the development of safeguards information treatment system at the facility level

    Energy Technology Data Exchange (ETDEWEB)

    Lee, B. D.; Song, D. Y.; So, D. S.; Kwak, E. H. [KAERI, Taejon (Korea, Republic of)

    2000-05-01

    Safeguards Information Treatment System(SITS) at the facility level is required to implement efficiently the obligations under the Korea-IAEA Safeguards Agreement, bilateral agreements with other countries and domestic law. In this paper, the requirements and major functions of SITS were considered, and the error checking methods and the relationships of safeguards information were reviewed. SITS will be developed to cover the different accounting procedures and methods applied at the various facilities under IAEA safeguards. Also, the resolved result of the Y2K problem in the existing nuclear material accounting program was described.

  2. Technical report of comparison in design control on R and D and industrial quality requirements

    International Nuclear Information System (INIS)

    Kim, Kwan Hyun

    2000-06-01

    This technical report provides the methods on how to establish the requirements on nuclear R and D facilities. This report applies to the quality assurance(QA) programmes of the design, fabrication in research reactor. The organization having overall responsibility for the nuclear power item design, preservation, fabrication shall be described in this report in each stage of nuclear project

  3. PEFC R&D technology at Toyota

    Energy Technology Data Exchange (ETDEWEB)

    Kawatsu, Shigeyuki; Aoyama, Satoshi; Iwase, Masayoshi [Toyota Motor Corp., Shizuoka (Japan)

    1996-12-31

    Fuel cells are being considered as notable new energy sources due to, not only their potential for obtaining high energy conversion efficiencies, but also their environmental sensitive features. These are especially important now that the problems relating to global environmental pollution are regarded as serious social issues. Polymer electrolyte fuel cells (PEFCs) in particular are being pursued due in part to the prospect of realizing timely enhancements to several key characteristics, including size and power. Encouraged by these anticipated improvements, PEFCs are being investigated as promising power generator candidates for hybrid electric vehicles. The substantial future potential of PEFCs has been noted by TOYOTA, and has motivated extensive R&D activities toward the practical application of PEFCs to hybrid electric vehicles. These R&D efforts include, not only activities on such key areas as performance enhancement, but also extensive attention to a broad range of related concerns, such as cost reduction, reformer development, system integration, durability, reliability and so on. From these diverse tasks, this paper focuses on the issues related to ensuring adequate PEFC performance when reformed fuel is utilized. Recent outcomes of R&D conducted at TOYOTA on this topic will be described.

  4. Informal Innovation

    DEFF Research Database (Denmark)

    Hartmann, Mia Rosa Koss; Hartmann, Rasmus Koss

    Informal innovation, defined as the development and putting-into-use of novel solutions by non-R&D employees without prior formal approval from or subsequent revealing to superiors, has been recurrently observed in organizational research. But even as it is increasingly recognized that R&D is not......Informal innovation, defined as the development and putting-into-use of novel solutions by non-R&D employees without prior formal approval from or subsequent revealing to superiors, has been recurrently observed in organizational research. But even as it is increasingly recognized that R......&D is not the only plausible source of innovation inside organizations, informal innovation has yet to be systematically explored or theorized. We propose a theory of informal innovation based on analyses of prior literature and mixed-method, multi-site studies of innovation at the working level of two extreme......-case organizations. We propose that informal innovation occurs as 1) employees personally experience problems that they believe are not recognized or prioritized by superiors; 2) some employees are able to develop solutions, essentially at no cost; 3) innovators face no benefits from revealing to superiors, but can...

  5. Current Requirements of the Society to the Professional Training of Specialists in Information Technology Industry in Japan

    Science.gov (United States)

    Pododimenko, Inna

    2014-01-01

    The problem of professional training of skilled human personnel in the industry of information communication technology, the urgency of which is recognized at the state level of Ukraine and the world, has been considered. It has been traced that constantly growing requirements of the labour market, swift scientific progress require the use of…

  6. R2R - software to speed the depiction of aesthetic consensus RNA secondary structures

    Directory of Open Access Journals (Sweden)

    Weinberg Zasha

    2011-01-01

    Full Text Available Abstract Background With continuing identification of novel structured noncoding RNAs, there is an increasing need to create schematic diagrams showing the consensus features of these molecules. RNA structural diagrams are typically made either with general-purpose drawing programs like Adobe Illustrator, or with automated or interactive programs specific to RNA. Unfortunately, the use of applications like Illustrator is extremely time consuming, while existing RNA-specific programs produce figures that are useful, but usually not of the same aesthetic quality as those produced at great cost in Illustrator. Additionally, most existing RNA-specific applications are designed for drawing single RNA molecules, not consensus diagrams. Results We created R2R, a computer program that facilitates the generation of aesthetic and readable drawings of RNA consensus diagrams in a fraction of the time required with general-purpose drawing programs. Since the inference of a consensus RNA structure typically requires a multiple-sequence alignment, the R2R user annotates the alignment with commands directing the layout and annotation of the RNA. R2R creates SVG or PDF output that can be imported into Adobe Illustrator, Inkscape or CorelDRAW. R2R can be used to create consensus sequence and secondary structure models for novel RNA structures or to revise models when new representatives for known RNA classes become available. Although R2R does not currently have a graphical user interface, it has proven useful in our efforts to create 100 schematic models of distinct noncoding RNA classes. Conclusions R2R makes it possible to obtain high-quality drawings of the consensus sequence and structural models of many diverse RNA structures with a more practical amount of effort. R2R software is available at http://breaker.research.yale.edu/R2R and as an Additional file.

  7. R2R - software to speed the depiction of aesthetic consensus RNA secondary structures

    Science.gov (United States)

    2011-01-01

    Background With continuing identification of novel structured noncoding RNAs, there is an increasing need to create schematic diagrams showing the consensus features of these molecules. RNA structural diagrams are typically made either with general-purpose drawing programs like Adobe Illustrator, or with automated or interactive programs specific to RNA. Unfortunately, the use of applications like Illustrator is extremely time consuming, while existing RNA-specific programs produce figures that are useful, but usually not of the same aesthetic quality as those produced at great cost in Illustrator. Additionally, most existing RNA-specific applications are designed for drawing single RNA molecules, not consensus diagrams. Results We created R2R, a computer program that facilitates the generation of aesthetic and readable drawings of RNA consensus diagrams in a fraction of the time required with general-purpose drawing programs. Since the inference of a consensus RNA structure typically requires a multiple-sequence alignment, the R2R user annotates the alignment with commands directing the layout and annotation of the RNA. R2R creates SVG or PDF output that can be imported into Adobe Illustrator, Inkscape or CorelDRAW. R2R can be used to create consensus sequence and secondary structure models for novel RNA structures or to revise models when new representatives for known RNA classes become available. Although R2R does not currently have a graphical user interface, it has proven useful in our efforts to create 100 schematic models of distinct noncoding RNA classes. Conclusions R2R makes it possible to obtain high-quality drawings of the consensus sequence and structural models of many diverse RNA structures with a more practical amount of effort. R2R software is available at http://breaker.research.yale.edu/R2R and as an Additional file. PMID:21205310

  8. R2R--software to speed the depiction of aesthetic consensus RNA secondary structures.

    Science.gov (United States)

    Weinberg, Zasha; Breaker, Ronald R

    2011-01-04

    With continuing identification of novel structured noncoding RNAs, there is an increasing need to create schematic diagrams showing the consensus features of these molecules. RNA structural diagrams are typically made either with general-purpose drawing programs like Adobe Illustrator, or with automated or interactive programs specific to RNA. Unfortunately, the use of applications like Illustrator is extremely time consuming, while existing RNA-specific programs produce figures that are useful, but usually not of the same aesthetic quality as those produced at great cost in Illustrator. Additionally, most existing RNA-specific applications are designed for drawing single RNA molecules, not consensus diagrams. We created R2R, a computer program that facilitates the generation of aesthetic and readable drawings of RNA consensus diagrams in a fraction of the time required with general-purpose drawing programs. Since the inference of a consensus RNA structure typically requires a multiple-sequence alignment, the R2R user annotates the alignment with commands directing the layout and annotation of the RNA. R2R creates SVG or PDF output that can be imported into Adobe Illustrator, Inkscape or CorelDRAW. R2R can be used to create consensus sequence and secondary structure models for novel RNA structures or to revise models when new representatives for known RNA classes become available. Although R2R does not currently have a graphical user interface, it has proven useful in our efforts to create 100 schematic models of distinct noncoding RNA classes. R2R makes it possible to obtain high-quality drawings of the consensus sequence and structural models of many diverse RNA structures with a more practical amount of effort. R2R software is available at http://breaker.research.yale.edu/R2R and as an Additional file.

  9. UNDERSTANDING THAI CULTURE AND ITS IMPACT ON REQUIREMENTS ENGINEERING PROCESS MANAGEMENT DURING INFORMATION SYSTEMS DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Theerasak Thanasankit

    2002-01-01

    Full Text Available This paper explores the impact of Thai culture on managing the decision making process in requirements engineering and contribution a better understand of its influence on the management of requirements engineering process. The paper illustrates the interaction of technology and culture and shows that rather than technology changing culture, culture can change the way technology is used. Thai culture is naturally inherent in Thai daily life and Thais bring that into their work practices. The concepts of power and uncertainty in Thai culture contribute toward hierarchical forms of communication and decision making process in Thailand, especially during requirements engineering, where information systems requirements need to be established for further development. The research shows that the decision making process in Thailand tends to take a much longer time, as every stage during requirements engineering needs to be reported to management for final decisions. The tall structure of Thai organisations also contributes to a bureaucratic, elongated decision-making process during information systems development. Understanding the influence of Thai culture on requirements engineering and information systems development will assist multinational information systems consulting organisations to select, adapt, better manage, or change requirements engineering process and information systems developments methodologies to work best with Thai organisations.

  10. Measurements of coronal Faraday rotation at 4.6 R

    International Nuclear Information System (INIS)

    Kooi, Jason E.; Fischer, Patrick D.; Buffo, Jacob J.; Spangler, Steven R.

    2014-01-01

    Many competing models for the coronal heating and acceleration mechanisms of the high-speed solar wind depend on the solar magnetic field and plasma structure in the corona within heliocentric distances of 5 R ☉ . We report on sensitive Very Large Array (VLA) full-polarization observations made in 2011 August, at 5.0 and 6.1 GHz (each with a bandwidth of 128 MHz) of the radio galaxy 3C 228 through the solar corona at heliocentric distances of 4.6-5.0 R ☉ . Observations at 5.0 GHz permit measurements deeper in the corona than previous VLA observations at 1.4 and 1.7 GHz. These Faraday rotation observations provide unique information on the magnetic field in this region of the corona. The measured Faraday rotation on this day was lower than our a priori expectations, but we have successfully modeled the measurement in terms of observed properties of the corona on the day of observation. Our data on 3C 228 provide two lines of sight (separated by 46'', 33,000 km in the corona). We detected three periods during which there appeared to be a difference in the Faraday rotation measure between these two closely spaced lines of sight. These measurements (termed differential Faraday rotation) yield an estimate of 2.6-4.1 GA for coronal currents. Our data also allow us to impose upper limits on rotation measure fluctuations caused by coronal waves; the observed upper limits were 3.3 and 6.4 rad m –2 along the two lines of sight. The implications of these results for Joule heating and wave heating are briefly discussed.

  11. Fisher Information and the Quantum Cramér-Rao Sensitivity Limit of Continuous Measurements

    DEFF Research Database (Denmark)

    Gammelmark, Søren; Mølmer, Klaus

    2014-01-01

    Precision measurements with quantum systems rely on our ability to trace the differences between experimental signals to variations in unknown physical parameters. In this Letter we derive the Fisher information and the ensuing Cramér-Rao sensitivity limit for parameter estimation by continuous...

  12. RNA sequence analyses of r-Moj-DM treated cells: TXNIP is required to induce apoptosis of SK-Mel-28.

    Science.gov (United States)

    McBride, Terri D; Andrew, U; Ly, Nicko; Soto, Julio G

    2016-10-01

    RNA sequencing of untreated and r-Moj-DM treated SK-Mel-28 cells was performed after 6 h, to begin unraveling the apoptotic pathway induced by r-Moj-DM. Bioinformatic analyses of RNA sequencing data yielded 40 genes that were differentially expressed. Nine genes were upregulated and 31 were downregulated. qRT-PCR was used to validate differential expression of 13 genes with known survival or apoptotic-inducing activities. Expression of BNiP3, IGFBP3, PTPSF, Prune 2, TGF-ß, and TXNIP were compared from cells treated with r-Moj-DN (a strong apoptotic inducer) or r-Moj-DA (a non-apoptotic inducer) for 1 h, 2 h, 4 h, and 6 h after treatment. Our results demonstrate that significant differences in expression are only detected after 4 h of treatment. In addition, expression of TXNIP (an apoptotic inducer) remains elevated at 4 h and 6 h only in r-Moj-DN treated cells. Based on the consistency of elevated TXNIP expression, we further studied TXNIP as a novel target of disintegrin activation. Confocal microscopy of anti-TXNIP stained SK-Mel-28 cells suggests nuclear localization of TXNIP after r-Moj-DM treatment. A stable TXNIP knockdown SK-Mel-28 cell line was produced to test TXNIP' role in the apoptotic induction by r-Moj-DM. High cell viability (74.3% ±9.1) was obtained after r-Moj-DM treatment of TXNIP knocked down SK-Mel-28 cells, compared to 34% ±0.187 for untransduced cells. These results suggest that TXNIP is required early in the apoptotic-inducing pathway resulting from r-Moj-DM binding to the αv integrin subunit. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. 30 CFR 250.242 - What information must accompany the DPP or DOCD?

    Science.gov (United States)

    2010-07-01

    ... § 250.248; (g) Air emissions information required by § 250.249; (h) Oil and hazardous substance spills...? 250.242 Section 250.242 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR....258; (q) Sulphur operations information required by § 250.259; (r) Coastal zone management information...

  14. Report: EPA’s Information Systems and Data Are at Risk Due to Insufficient Training of Personnel With Significant Information Security Responsibilities

    Science.gov (United States)

    Report #14-P-0142, March 21, 2014. The EPA places its information systems and data at risk due to an organizational structure that has not specified required duties and responsibilities to ensure personnel are trained on key information security roles.

  15. 47 CFR 25.263 - Information sharing requirements for SDARS terrestrial repeater operators.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Information sharing requirements for SDARS terrestrial repeater operators. 25.263 Section 25.263 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES SATELLITE COMMUNICATIONS Technical Standards § 25.263 Information sharing...

  16. Identifying and confirming information and system quality requirements for multi-agency disaster management

    NARCIS (Netherlands)

    Bharosa, N.; Appelman, J.A.; Van Zanten, B.; Zuurmond, A.

    2009-01-01

    This paper investigates the relevance and assurance of information and system quality as requirements for information systems success during disaster management. Despite the many examples of poor information quality and poor system quality, research on the relevance and assurance of these

  17. Heat release, time required, and cleaning ability of MTwo R and ProTaper universal retreatment systems in the removal of filling material.

    Science.gov (United States)

    Bramante, Clovis Monteiro; Fidelis, Natasha Siqueira; Assumpção, Tatiana Santos; Bernardineli, Norberti; Garcia, Roberto Brandão; Bramante, Alexandre Silva; de Moraes, Ivaldo Gomes

    2010-11-01

    This ex vivo study evaluated the heat release, time required, and cleaning efficacy of MTwo (VDW, Munich, Germany) and ProTaper Universal Retreatment systems (Dentsply/Maillefer, Ballaigues, Switzerland) and hand instrumentation in the removal of filling material. Sixty single-rooted human teeth with a single straight canal were obturated with gutta-percha and zinc oxide and eugenol-based cement and randomly allocated to 3 groups (n = 20). After 30-day storage at 37 °C and 100% humidity, the root fillings were removed using ProTaper UR, MTwo R, or hand files. Heat release, time required, and cleaning efficacy data were analyzed statistically (analysis of variance and the Tukey test, α = 0.05). None of the techniques removed the root fillings completely. Filling material removal with ProTaper UR was faster but caused more heat release. Mtwo R produced less heat release than the other techniques but was the least efficient in removing gutta-percha/sealer. ProTaper UR and MTwo R caused the greatest and lowest temperature increase on root surface, respectively; regardless of the type of instrument, more heat was released in the cervical third. Pro Taper UR needed less time to remove fillings than MTwo R. All techniques left filling debris in the root canals. Copyright © 2010 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

  18. Development and Current Practice in Using R at Statistics Austria

    Directory of Open Access Journals (Sweden)

    Matthias Templ

    2014-06-01

    Full Text Available The popularity of R is increasing in national statistical offices not only for simulation tasks. Nowadays R is also used in the production process. A lot of new features for various tasks in official statistics have been developed over the last years and these features are freely available in the form of add-on package. In this contribution we first give an outline of the use of R at Statistics Austria. Discussed is the necessary infrastructure according to the R-installation, the teaching of employees and the support provided to the staff who use R in their daily work. In the second part, the R developments from the methods unit at Statistics Austria are summarised. The developed packages include methods for data pre-processing (e.g imputation up to packages for the final dissemination of data including packages for statistical disclosure control, estimation of indicators and the visualisation of results.

  19. A Business Goal Driven Approach for Understanding and Specifying Information Security Requirements

    NARCIS (Netherlands)

    Su, X.; Bolzoni, D.; van Eck, Pascal

    In this paper we present an approach for specifying and prioritizing information security requirements in organizations. It is important to prioritize security requirements since hundred per cent security is not achievable and the limited resources available should be directed to satisfy the most

  20. 50 CFR 86.16 - What are the information collection requirements?

    Science.gov (United States)

    2010-10-01

    ... THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM BOATING... of information Number ofrespondents* Average time required per response(minutes) Annual burden hours... Management and Budget, Department of Interior, Desk Officer, 1849 C Street, NW., Washington, DC 20503. An...

  1. 20 CFR 703.203 - Application for security deposit determination; information to be submitted; other requirements.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Application for security deposit determination; information to be submitted; other requirements. 703.203 Section 703.203 Employees' Benefits... each insurance rating service designated by the Branch and posted on the Internet at http://www.dol.gov...

  2. Ergonomic requirements on computer-based information- and handling engineering in nuclear power plants

    International Nuclear Information System (INIS)

    Fassmann, W.

    2002-01-01

    This project provides regulatory authorities with a set of criteria for evaluating hybrid man-machine interfaces in nuclear power plant control rooms from a human factors point of view. Such standards are necessary for two reasons: (1) More and more computerised information and control systems have been and will be introduced in nuclear power plant control rooms. One possible result of this trend will be the creation of hybrid man machine interfaces which will provide both conventional and computer-based display and control devices. (2) Available rules and regulations do not contain detailed requirements on how to integrate both types of interface in such a way that plant operation by means of hybrid interfaces will be performed at least as reliably and safely as by means of conventional ones. To fill this gap, criteria and methods were developed which support practical checks of requirements to be applied to hybrid control rooms. This approach is based on state of the art methods and criteria in ergonomics. It makes it possible to analyse and to describe personnel's actions in a consistent and structured way in order to provide the information which is necessary for evaluating human reliability of task performance. Reliability can be evaluated with respect to - accuracy of required information on displays, - networking of tasks, - possibilities of interrupting and cancelling measures which have already been initiated, - possibility to carry out required manuel actions, - level of mental work-strain, - workload level, - probability of erroneous actions. This method is part of a catalogue of recommendations for evaluating hybrid nuclear power plant control rooms. The catalogue also contains recommendations for the design of computerised parts of the man-machine-interface. Application of these design recommendations will help create favourable conditions for an acceptable level of work-strain and for reliable task performance. (orig.) [de

  3. Integrated management system for radioactive waste repositories (SGI3R)

    International Nuclear Information System (INIS)

    Silva, Fabio; Tello, Cledola Cassia Oliveira de

    2009-01-01

    The implantation of a repository for radioactive wastes is a multidisciplinary project that needs specialists of different areas of knowledge, interaction with public and private institutions, data and information related to radioactive wastes, geology, technology etc. All the activities must be in accordance with norms, requirements and procedures, including national and international legislation. The maintenance of the waste inventory records is an important regulatory requirement and must be available even after the closure of the repository. CDTN - Center of Nuclear Technology Development - is coordinating the Project for the construction of the national repository to dispose the low -and intermediate-level wastes. In order to consolidate all information that will come from this Project, it is being developed and implanted in CDTN a manager system of database, called Integrated Management System for Radioactive Waste Repositories (SGI3R), which will also manage all data from previous work carried out in Brazil and around the world about this subject. The proposal is to build a structure of modules, having as base eight modules: inventory, site selection, types of repository, technology, partners, legislation, communication and documents. The SGI3R running comprises the data processing (inclusion, update and exclusion), integration, standardization, and consistency among the processes. The SGI3R will give support to the stages of this Project, which will allow the preservation of all the available information, preventing duplication of efforts and additional costs, improving, in this way, the Project planning and execution. Additionally the SGI3R will make possible the information access to all stakeholders. (author)

  4. 75 FR 38975 - Proposed Information Collection; Comment Request; Foreign Fishing Reporting Requirements

    Science.gov (United States)

    2010-07-07

    ... Collection; Comment Request; Foreign Fishing Reporting Requirements AGENCY: National Oceanic and Atmospheric...-2276 or [email protected] . SUPPLEMENTARY INFORMATION: I. Abstract Foreign fishing activities can be... abundance of the species. This notice is for the extension of a currently approved information collection...

  5. Nursery school at Vincennes: O.P.R.I. investigation

    International Nuclear Information System (INIS)

    Pasquier, J.L.; Fouquet, G.; Linden, G.

    2001-01-01

    After five children neoplasms at the nursery of Vincennes, the O.P.R.I. has realised two measurement campaigns during the year 2001. The track of a radioactive contamination, based on the private laboratory analysis has been denied by O.P.R.I. (N.C.)

  6. R-744 compared to R-290 in small freezer applications; R-744 versus R-290 in kleine vriezer-toepassingen

    Energy Technology Data Exchange (ETDEWEB)

    Van Beek, M.; Janssen, M. [Re/gent, Helmond (Netherlands)

    2009-04-15

    An experimental and analytical comparison between R-744 (CO2) and R-290 (propane) as refrigerant for small capacity freezer applications is described. A commercially available plug-in freezer cabinet for sales of frozen foods or ice cream, fitted with an R-290 (8,1 cm{sup 3}) hermetic compressor, was retrofitted to R-744 using standard components and a state of the art R-744 compressor. The results of energy consumption and storage temperature testing on both systems are presented as well as a discussion on the system modifications required for using R-744. Both refrigerant loops are analyzed and the deviations with the thermodynamically ideal loops are discussed. The analysis is further supported by calorimetric tests of the R-744 compressor at low evaporation temperatures. Theoretical comparison of the ideal loops, using performance data from the compressors used in the experiments, shows that the R-744 circuit is 31% less efficient than the R-290 circuit, at normal operating conditions for frozen foods or ice cream. Comparison of the experimental result; from the almost fully optimized R-744 freezer with a standard R-290 freezer at an ambient temperature of 30C shows that the R-744 freezer is only 13% less efficient than the R-290 freezer at an average product temperature of 23C. The differences between the ideal and the real loops are analyzed. Finally, costs of major components of both systems are evaluated. This shows that the difference in production costs between an R-744 and an R-290 freezer is mainly driven by the compressor. [Dutch] Een experimentele en analytische vergelijking is uitgvoerd tussen R-744 (CO2) en R-290 (propaan) als koudemiddel in kleine vriezer-toepassingen. Een standaard vrieskist voor de verkoop van ijs en voorzien van een hermetische R-290 compressor is geconverteerd naar R-744, gebruikmakend van standaard componenten en een semi-hermetische R-744 compressor. De resultaten van energiegebruik- en temperatuurprestatietesten uitgevoerd

  7. New legal requirements for submission of product information to poisons centres in EU member states.

    Science.gov (United States)

    de Groot, Ronald; Brekelmans, Pieter; Desel, Herbert; de Vries, Irma

    2018-01-01

    In the past eight years, the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) has been intensively involved in a European Commission led process to develop EU legislation on the information of hazardous products that companies have to notify to EU Poisons Centres (or equivalent "appointed bodies"). As a result of this process, the Commission adopted Regulation (EU) No 2017/542, amending the CLP Regulation by adding an Annex on harmonised product submission requirements. Harmonised mixture information requirements: Detailed and consistent information on the composition of the hazardous product will become available to EU Poisons Centres (PC). The information will be submitted by companies to PCs (or equivalent "appointed bodies") using a web-based software application or in-house software. Two new important features are introduced. Firstly, to be able to rapidly identify the product formula, a Unique Formula Identifier (UFI) on the product label links to the submitted information. Secondly, for better comparability of reports on poisonings between EU member states, a harmonised Product Categorisation System will specify the intended use of a product. Rapid product identification and availability of detailed composition information will lead to timely and adequate medical intervention. This may lead to considerable reduction in healthcare costs. Additionally, for companies trading across the EU, costs of submission of this information will be reduced significantly. Next steps: From 2017, an implementation period has started, consisting of a three-year period for stakeholders to implement the new requirements, followed by a gradual applicability for consumer products (2020), professional products (2021) and industrial use-only products (2024). Technical tools to generate the electronic format and the UFI together with guidance documents are expected to be made available by the end of 2017 by the European Chemicals Agency (ECHA). Guidance on

  8. How Long Should Routine EEG Be Recorded to Get Relevant Information?

    Science.gov (United States)

    Doudoux, Hannah; Skaare, Kristina; Geay, Thomas; Kahane, Philippe; Bosson, Jean L; Sabourdy, Cécile; Vercueil, Laurent

    2017-03-01

    The optimal duration of routine EEG (rEEG) has not been determined on a clinical basis. This study aims to determine the time required to obtain relevant information during rEEG with respect to the clinical request. All rEEGs performed over 3 months in unselected patients older than 14 years in an academic hospital were analyzed retrospectively. The latency required to obtain relevant information was determined for each rEEG by 2 independent readers blinded to the clinical data. EEG final diagnoses and latencies were analyzed with respect to the main clinical requests: subacute cognitive impairment, spells, transient focal neurologic manifestation or patients referred by epileptologists. From 430 rEEGs performed in the targeted period, 364 were analyzed: 92% of the pathological rEEGs were provided within the first 10 minutes of recording. Slowing background activity was diagnosed from the beginning, whereas interictal epileptiform discharges were recorded over time. Moreover, the time elapsed to demonstrate a pattern differed significantly in the clinical groups: in patients with subacute cognitive impairment, EEG abnormalities appeared within the first 10 minutes, whereas in the other groups, data could be provided over time. Patients with subacute cognitive impairment differed from those in the other groups significantly in the elapsed time required to obtain relevant information during rEEG, suggesting that 10-minute EEG recordings could be sufficient, arguing in favor of individualized rEEG. However, this conclusion does not apply to intensive care unit patients.

  9. 3D Geo-Information requirements for disaster and emergency management

    NARCIS (Netherlands)

    Demir Ozbek, E.; Zlatanova, S.; Ates Aydar, S.; Yomralioglu, T

    2016-01-01

    A conceptual approach is proposed to define 3D geo-information requirement for different types of disasters. This approach includes components such as Disaster Type-Sector-Actor-Process-Activity-Task-Data. According to disaster types processes, activities, tasks, sectors, and responsible and

  10. Risk - Informed decision making at Loviisa NPP

    International Nuclear Information System (INIS)

    Vaurio, J.K.

    1999-01-01

    PSA has been used in many ways for risk-informed decision making at Loviisa power station. The most fruitful areas so far include: 1) Identification of dominating risk contributors and possible means for reducing risk by plant modification and improved procedures. 2) Providing risk perspective and economic criteria for assessing backfitting proposals. 3) Assessing the significance of ageing and needs for renewals. 4) Limiting, prioritising and optimising plant modifications. 5) Reducing testing requirements. 6) Justification of temporary as well as permanent configurations and extended outage times. 7) Planning and prioritisation of training programs. (au)

  11. Risk - Informed decision making at Loviisa NPP

    Energy Technology Data Exchange (ETDEWEB)

    Vaurio, J.K. [Fortum Power and Heat Oy, Loviisa (Finland)

    1999-09-01

    PSA has been used in many ways for risk-informed decision making at Loviisa power station. The most fruitful areas so far include: 1) Identification of dominating risk contributors and possible means for reducing risk by plant modification and improved procedures. 2) Providing risk perspective and economic criteria for assessing backfitting proposals. 3) Assessing the significance of ageing and needs for renewals. 4) Limiting, prioritising and optimising plant modifications. 5) Reducing testing requirements. 6) Justification of temporary aswell as permanent configurations and extended outage times. 7) Planning and prioritisation of training programs. (au)

  12. R and D on Transmutation at CEA: Recent Results

    International Nuclear Information System (INIS)

    Royet, V.; Delahaye, T.; Lebreton, F.; Picart, S.; Caisso, M.; Gauthe, A.; Ode, D.; Tronche, E.; Bayle, J.P; Warin, D.; Bejaoui, S.; Delage, F.

    2015-01-01

    In the field of minor actinide transmutation in future Generation IV SFR reactor, CEA investigates in priority the recycling of Americium (Am) in the radial blankets located in the outer core area (AmBB: Americium Bearing Blankets). This paper gives an overview of the recent outcomes of the R and D programme carried out at CEA in the different fields of research: from powder elaboration to experimental irradiation. Concerning the powder elaboration, several batches have been produced by the oxalic co-conversion route as well as by the Calcined Resin Microsphere Pelletizing. Different tests have been then performed for the fabrication of pellets according to the current specifications of AmBB. For these two processes, different additional developments of innovative technologies have been achieved well adapted with the processes constraints and hot cell operating. Information on irradiation programmes (MARIOS in HFR and ongoing DIAMINO in Osiris) are presented. The next steps of the programme will then be tackled. (authors)

  13. 34 CFR 403.193 - What are the information requirements regarding special populations?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What are the information requirements regarding special... TECHNOLOGY EDUCATION PROGRAM What Conditions Must be Met by Local Recipients? § 403.193 What are the... their parents information concerning— (i) The opportunities available in vocational education; (ii) The...

  14. 75 FR 12552 - Agency Information Collection Activities; Proposed Collection; Comment Request; Requirements...

    Science.gov (United States)

    2010-03-16

    ... Budget (OMB) for each collection of information they conduct or sponsor. ``Collection of information'' is... advertising and packaging. FDA is required to review each plan submitted and approve the plan if it provides..., involving multiple brands, multiple brand varieties, and multiple forms of both packaging and advertising...

  15. Measuring the risk of an Iranian banking system using Value at Risk (VaR Model

    Directory of Open Access Journals (Sweden)

    Sudabeh Morshedian Rafiee

    2012-10-01

    Full Text Available Measuring risk of financial institutes and banks plays an important role on managing them. Recent financial turmoil in United States banking system has motivated banking industry to monitor risk factors more closely. In this paper, we present an empirical study to measure the risk of some private banks in Iran called Bank Mellat using Value at Risk (VaR method. The proposed study collects the necessary information for the fiscal year of 2010 and analyses them using regression analysis. The study divides the financial data into two groups where the financial data of the first half of year is considered in the first group and the remaining information for the second half of year 2010 is considered in the second group. The implementation of VaR method indicates that financial risks increase during the time horizon. The study also uses linear regression method where independent variable is time, dependent variable is the financial risk, and the results confirm what we have found in the previous part of the survey.

  16. 77 FR 6815 - Agency Information Collection Activities: Country of Origin Marking Requirements for Containers...

    Science.gov (United States)

    2012-02-09

    ... Activities: Country of Origin Marking Requirements for Containers or Holders AGENCY: U.S. Customs and Border... information collection requirement concerning Country of Origin Marking Requirements for Containers or Holders...: Title: Country of Origin Marking Requirements for Containers or Holders. OMB Number: 1651-0057. Form...

  17. Quo vadimus: Coming to grips with the information world

    Science.gov (United States)

    Blados, Walter R.

    1991-01-01

    The new information-oriented culture in which we find ourselves has created new relationships, new stimulating and expanding opportunities, new methods of doing our work, and new environments in which we carry out our work. An integral part of the NASA aerospace research and development (R and D) process is the scientific and technical information (STI) associated with it; it is both a raw material (input) and a product (output) of this process. Within this process, the NASA STI Program is tasked to provide information management and services, to ensure that accurate and timely STI is generated and entered into an appropriate information service and made available in a usable form to those who have a need for it; in essence, a means to exploit both internal (NASA corporate) and pertinent external (other governmental/industrial/foreign) information to meet the requirements of the R and D community. To understand the STI Program management issues, it is critical to understand the role of the STI Program in the context of the R and D process. STI management must become part of the accepted culture of the R and D community, but it cannot become so unless adopted and accepted by it. A start should be made now to integrate the NASA STI Program into the R and D infrastructure, including funding and operational control. Within this infrastructure, we must obtain management commitment, review and produce policy reflecting the organizational status, allocate responsibilities, and set to work on implementing the true requirements of the R and D community.

  18. Medium energy electron cooling R and D at Fermilab -- Context and status

    International Nuclear Information System (INIS)

    MacLachlan, J.A.

    1996-05-01

    Electron cooling at the proposed Recycler 8 GeV storage ring has been identified as a key element in exploiting the capacity of the Fermilab Main Injector for an additional factor of ten in Tevatron luminosity above the goal for the next collider run, ultimately to > 10 33 cm -2 s -1 . The most basic requirement for increased luminosity is a large stack of antiprotons cooled to emittance comparable to that of the proton beam. Although electron cooling is inferior to the stochastic technique for cooling large emittance beams, its rate is practically independent of the antiproton intensity. For cooling intense beams of low or moderate emittance, electron cooling excels. The realization of electron cooling for 8 GeV antiprotons requires major extension of existing practice in electron energy and length of the cooling interaction region. It will require 4.3 MeV dc electron beam maintaining high quality and precise collinearity with the antiprotons over a 66 m straight section. The initial goal of the R and D project is 200 mA electron current in about three years; the plan is to reach 2 A over the following three years

  19. Search for R-parity violating decays of sfermions at LEP

    CERN Document Server

    Abbiendi, G.; Akesson, P.F.; Alexander, G.; Allison, John; Amaral, P.; Anagnostou, G.; Anderson, K.J.; Arcelli, S.; Asai, S.; Axen, D.; Azuelos, G.; Bailey, I.; Barberio, E.; Barlow, R.J.; Batley, R.J.; Bechtle, P.; Behnke, T.; Bell, Kenneth Watson; Bell, P.J.; Bella, G.; Bellerive, A.; Benelli, G.; Bethke, S.; Biebel, O.; Boeriu, O.; Bock, P.; Boutemeur, M.; Braibant, S.; Brigliadori, L.; Brown, Robert M.; Buesser, K.; Burckhart, H.J.; Campana, S.; Carnegie, R.K.; Caron, B.; Carter, A.A.; Carter, J.R.; Chang, C.Y.; Charlton, David G.; Csilling, A.; Cuffiani, M.; Dado, S.; De Roeck, A.; De Wolf, E.A.; Desch, K.; Dienes, B.; Donkers, M.; Dubbert, J.; Duchovni, E.; Duckeck, G.; Duerdoth, I.P.; Etzion, E.; Fabbri, F.; Feld, L.; Ferrari, P.; Fiedler, F.; Fleck, I.; Ford, M.; Frey, A.; Furtjes, A.; Gagnon, P.; Gary, John William; Gaycken, G.; Geich-Gimbel, C.; Giacomelli, G.; Giacomelli, P.; Giunta, Marina; Goldberg, J.; Gross, E.; Grunhaus, J.; Gruwe, M.; Gunther, P.O.; Gupta, A.; Hajdu, C.; Hamann, M.; Hanson, G.G.; Harder, K.; Harel, A.; Harin-Dirac, M.; Hauschild, M.; Hawkes, C.M.; Hawkings, R.; Hemingway, R.J.; Hensel, C.; Herten, G.; Heuer, R.D.; Hill, J.C.; Hoffman, Kara Dion; Horvath, D.; Igo-Kemenes, P.; Ishii, K.; Jeremie, H.; Jovanovic, P.; Junk, T.R.; Kanaya, N.; Kanzaki, J.; Karapetian, G.; Karlen, D.; Kawagoe, K.; Kawamoto, T.; Keeler, R.K.; Kellogg, R.G.; Kennedy, B.W.; Kim, D.H.; Klein, K.; Klier, A.; Kluth, S.; Kobayashi, T.; Kobel, M.; Komamiya, S.; Kormos, Laura L.; Kramer, T.; Krieger, P.; von Krogh, J.; Kruger, K.; Kuhl, T.; Kupper, M.; Lafferty, G.D.; Landsman, H.; Lanske, D.; Layter, J.G.; Leins, A.; Lellouch, D.; Letts, J.; Levinson, L.; Lillich, J.; Lloyd, S.L.; Loebinger, F.K.; Lu, J.; Ludwig, J.; Macpherson, A.; Mader, W.; Marcellini, S.; Martin, A.J.; Masetti, G.; Mashimo, T.; Mattig, Peter; McDonald, W.J.; McKenna, J.; McMahon, T.J.; McPherson, R.A.; Meijers, F.; Menges, W.; Merritt, F.S.; Mes, H.; Michelini, A.; Mihara, S.; Mikenberg, G.; Miller, D.J.; Moed, S.; Mohr, W.; Mori, T.; Mutter, A.; Nagai, K.; Nakamura, I.; Nanjo, H.; Neal, H.A.; Nisius, R.; O'Neale, S.W.; Oh, A.; Okpara, A.; Oreglia, M.J.; Orito, S.; Pahl, C.; Pasztor, G.; Pater, J.R.; Patrick, G.N.; Pilcher, J.E.; Pinfold, J.; Plane, David E.; Poli, B.; Polok, J.; Pooth, O.; Przybycien, M.; Quadt, A.; Rabbertz, K.; Rembser, C.; Renkel, P.; Rick, H.; Roney, J.M.; Rosati, S.; Rozen, Y.; Runge, K.; Sachs, K.; Saeki, T.; Sarkisyan, E.K.G.; Schaile, A.D.; Schaile, O.; Scharff-Hansen, P.; Schieck, J.; Schoerner-Sadenius, Thomas; Schroder, Matthias; Schumacher, M.; Schwick, C.; Scott, W.G.; Seuster, R.; Shears, T.G.; Shen, B.C.; Sherwood, P.; Siroli, G.; Skuja, A.; Smith, A.M.; Sobie, R.; Soldner-Rembold, S.; Spano, F.; Stahl, A.; Stephens, K.; Strom, David M.; Strohmer, R.; Tarem, S.; Tasevsky, M.; Taylor, R.J.; Teuscher, R.; Thomson, M.A.; Torrence, E.; Toya, D.; Tran, P.; Trigger, I.; Trocsanyi, Z.; Tsur, E.; Turner-Watson, M.F.; Ueda, I.; Ujvari, B.; Vollmer, C.F.; Vannerem, P.; Vertesi, R.; Verzocchi, M.; Voss, H.; Vossebeld, J.; Waller, D.; Ward, C.P.; Ward, D.R.; Warsinsky, M.; Watkins, P.M.; Watson, A.T.; Watson, N.K.; Wells, P.S.; Wengler, T.; Wermes, N.; Wetterling, D.; Wilson, G.W.; Wilson, J.A.; Wolf, G.; Wyatt, T.R.; Yamashita, S.; Zer-Zion, D.; Zivkovic, Lidija

    2004-01-01

    A search for pair-produced scalar fermions under the assumption that R-parity is not conserved has been performed using data collected with the OPAL detector at LEP. The data samples analysed correspond to an integrated luminosity of about 610 pb-1 collected at centre-of-mass energies of sqrt(s) 189-209 GeV. An important consequence of R-parity violation is that the lightest supersymmetric particle is expected to be unstable. Searches of R-parity violating decays of charged sleptons, sneutrinos and squarks have been performed under the assumptions that the lightest supersymmetric particle decays promptly and that only one of the R-parity violating couplings is dominant for each of the decay modes considered. Such processes would yield final states consisting of leptons, jets, or both with or without missing energy. No significant single-like excess of events has been observed with respect to the Standard Model expectations. Limits on the production cross- section of scalar fermions in R-parity violating scena...

  20. Searches for Prompt R-Parity-Violating Supersymmetry at the LHC

    International Nuclear Information System (INIS)

    Redelbach, Andreas

    2015-01-01

    Searches for supersymmetry (SUSY) at the LHC frequently assume the conservation of R-parity in their design, optimization, and interpretation. In the case that R-parity is not conserved, constraints on SUSY particle masses tend to be weakened with respect to R-parity-conserving models. We review the current status of searches for R-parity-violating (RPV) supersymmetry models at the ATLAS and CMS experiments, limited to 8 TeV search results published or submitted for publication as of the end of March 2015. All forms of renormalisable RPV terms leading to prompt signatures have been considered in the set of analyses under review. Discussing results for searches for prompt R-parity-violating SUSY signatures summarizes the main constraints for various RPV models from LHC Run I and also defines the basis for promising signal regions to be optimized for Run II. In addition to identifying highly constrained regions from existing searches, also gaps in the coverage of the parameter space of RPV SUSY are outlined

  1. 50 CFR 84.12 - What are the information collection, record keeping, and reporting requirements?

    Science.gov (United States)

    2010-10-01

    ...), and financial reporting (43 CFR 12.81). The project report should include information about the acres... the information collection, record keeping, and reporting requirements? (a) Information collection... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false What are the information collection...

  2. Identification and summary characterization of materials potentially requiring vitrification: Background information

    International Nuclear Information System (INIS)

    Croff, A.G.

    1996-01-01

    This document contains background information for the Workshop in general and the presentation entitled 'Identification and Summary Characterization of Materials Potentially Requiring Vitrification' that was given during the first morning of the workshop. summary characteristics of 9 categories of US materials having some potential to be vitrified are given. This is followed by a 1-2 page elaborations for each of these 9 categories. References to more detailed information are included

  3. Information requirements of young women with breast cancer treated with mastectomy or breast conserving surgery: A systematic review.

    Science.gov (United States)

    Recio-Saucedo, Alejandra; Gerty, Sue; Foster, Claire; Eccles, Diana; Cutress, Ramsey I

    2016-02-01

    Young women with breast cancer have poorer prognosis, greater lifetime risk of local recurrence, contralateral recurrence, and distant disease, regardless of surgery received. Here we systematically review published evidence relating to the information requirements and preferences of young women diagnosed with early-stage breast cancer offered a choice between mastectomy and Breast Conservation Surgery (BCS). Findings will inform the development of a surgical decision aid for young women. Eight databases were searched to identify research examining information requirements of young women facing breast oncological surgery treatment decisions (MESH headings). Twelve studies met the inclusion criteria. Data were extracted and summarised in a narrative synthesis. Findings indicate that young women prefer greater and more detailed information regarding treatment side effects, sexuality, and body image. Younger age of diagnosis leads to an increased risk perception of developing a second breast cancer. Young women's choices are influenced by factors associated with family and career. Information is required in a continuum throughout the treatment experience and not only at diagnosis when treatment decisions are made. Young women show differing levels of participation preferences. Young women find decision-making challenging when the characteristics of diagnosis provide a surgical choice between mastectomy and breast conservation surgery. Efforts should be made to provide information regarding sexuality, body image, reconstruction, fertility and likelihood of familial predisposition. Further research is needed to identify the specific level and information requirements of this young-onset group. The low number of studies indicate a need to design studies targeting specifically this age group of breast cancer patients. Copyright © 2015 Elsevier Ltd. All rights reserved.

  4. Minimizing transfusion requirements for children undergoing craniosynostosis repair: the CHoR protocol.

    Science.gov (United States)

    Vega, Rafael A; Lyon, Camila; Kierce, Jeannette F; Tye, Gary W; Ritter, Ann M; Rhodes, Jennifer L

    2014-08-01

    Children with craniosynostosis may require cranial vault remodeling to prevent or relieve elevated intracranial pressure and to correct the underlying craniofacial abnormalities. The procedure is typically associated with significant blood loss and high transfusion rates. The risks associated with transfusions are well documented and include transmission of infectious agents, bacterial contamination, acute hemolytic reactions, transfusion-related lung injury, and transfusion-related immune modulation. This study presents the Children's Hospital of Richmond (CHoR) protocol, which was developed to reduce the rate of blood transfusion in infants undergoing primary craniosynostosis repair. A retrospective chart review of pediatric patients treated between January 2003 and Febuary 2012 was performed. The CHoR protocol was instituted in November 2008, with the following 3 components; 1) the use of preoperative erythropoietin and iron therapy, 2) the use of an intraoperative blood recycling device, and 3) acceptance of a lower level of hemoglobin as a trigger for transfusion (protocol implementation served as controls. A total of 60 children were included in the study, 32 of whom were treated with the CHoR protocol. The control (C) and protocol (P) groups were comparable with respect to patient age (7 vs 8.4 months, p = 0.145). Recombinant erythropoietin effectively raised the mean preoperative hemoglobin level in the P group (12 vs 9.7 g/dl, p protocol that includes preoperative administration of recombinant erythropoietin, intraoperative autologous blood recycling, and accepting a lower transfusion trigger significantly decreased transfusion utilization (p < 0.001). A decreased length of stay (p < 0.001) was seen, although the authors did not investigate whether composite transfusion complication reductions led to better outcomes.

  5. VaR Methodology Application for Banking Currency Portfolios

    Directory of Open Access Journals (Sweden)

    Daniel Armeanu

    2007-02-01

    Full Text Available VaR has become the standard measure that financial analysts use to quantify market risk. VaR measures can have many applications, such as in risk management, to evaluate the performance of risk takers and for regulatory requirements, and hence it is very important to develop methodologies that provide accurate estimates. In particular, the Basel Committee on Banking Supervision at the Bank for International Settlements imposes to financial institutions such as banks and investment firms to meet capital requirements based on VaR estimates. In this paper we determine VaR for a banking currency portfolio and respect rules of National Bank of Romania regarding VaR report.

  6. Large R jet reconstruction and calibration at 13 TeV with the ATLAS detector

    CERN Document Server

    Taenzer, Joe; The ATLAS collaboration

    2017-01-01

    Large-R jets are used by many ATLAS analyses working in boosted regimes. ATLAS Large-R jets are reconstructed from locally callibrated calorimeter topoclusters with the Anti-k_{t} algorithm with radius parameter R=1.0, and then groomed to remove pile-up with the trimming algorithm with f_{cut} 0.05 and subjet radius R=0.2. Monte Carlo based energy and mass calibrations correct the reconstructed jet energy and mass to truth, followed by in-situ calibrations using a number of different techniques. Large-R jets can also be reconstructed using small-R jets as constituents, instead of topoclusters, a technique called jet reclustering, or from track calo clusters (TCCs), which are constituents constructed using both tracking and calorimeter information. An overview of large-R jet reconstruction will be presented here, along with selected results from the jet mass calibrations, both Monte Carlo based an insitu, from jet reclustering, and from track calo clusters.

  7. Faculty Employment and R&D Expenditures at Research Universities

    Science.gov (United States)

    Zhang, Liang; Ehrenberg, Ronald G.

    2010-01-01

    This study uses panel data to examine the relationship between faculty employment and external R&D expenditures at Research and Doctoral institutions over a 15-year period of time. On average, a 1% increase in the number of full-time faculty is associated with about 0.2% increase in total R&D expenditure. Further, a one percentage point increase…

  8. Prototype development and demonstration for response, emergency staging, communications, uniform management, and evacuation (R.E.S.C.U.M.E.) : R.E.S.C.U.M.E. final functional and performance requirements.

    Science.gov (United States)

    2014-01-01

    This document provides the high-level functional and performance requirements for the Prototype Development and Demonstration : of a R.E.S.C.U.M.E. system. The requirements included in this document are based upon those that can be found in previous ...

  9. Searches for R-Parity Violating Decays of Gauginos at 183 GeV at LEP

    CERN Document Server

    Abbiendi, G.; Alexander, G.; Allison, John; Altekamp, N.; Anderson, K.J.; Anderson, S.; Arcelli, S.; Asai, S.; Ashby, S.F.; Axen, D.; Azuelos, G.; Ball, A.H.; Barberio, E.; Barlow, Roger J.; Bartoldus, R.; Batley, J.R.; Baumann, S.; Bechtluft, J.; Behnke, T.; Bell, Kenneth Watson; Bella, G.; Bellerive, A.; Bentvelsen, S.; Bethke, S.; Betts, S.; Biebel, O.; Biguzzi, A.; Bird, S.D.; Blobel, V.; Bloodworth, I.J.; Bock, P.; Bohme, J.; Bonacorsi, D.; Boutemeur, M.; Braibant, S.; Bright-Thomas, P.; Brigliadori, L.; Brown, Robert M.; Burckhart, H.J.; Capiluppi, P.; Carnegie, R.K.; Carter, A.A.; Carter, J.R.; Chang, C.Y.; Charlton, David G.; Chrisman, D.; Ciocca, C.; Clarke, P.E.L.; Clay, E.; Cohen, I.; Conboy, J.E.; Cooke, O.C.; Couyoumtzelis, C.; Coxe, R.L.; Cuffiani, M.; Dado, S.; Dallavalle, G.Marco; Davis, R.; De Jong, S.; de Roeck, A.; Dervan, P.; Desch, K.; Dienes, B.; Dixit, M.S.; Dubbert, J.; Duchovni, E.; Duckeck, G.; Duerdoth, I.P.; Eatough, D.; Estabrooks, P.G.; Etzion, E.; Fabbri, F.; Fanti, M.; Faust, A.A.; Fiedler, F.; Fierro, M.; Fleck, I.; Folman, R.; Furtjes, A.; Futyan, D.I.; Gagnon, P.; Gary, J.W.; Gascon, J.; Gascon-Shotkin, S.M.; Gaycken, G.; Geich-Gimbel, C.; Giacomelli, G.; Giacomelli, P.; Gibson, V.; Gibson, W.R.; Gingrich, D.M.; Glenzinski, D.; Goldberg, J.; Gorn, W.; Grandi, C.; Graham, K.; Gross, E.; Grunhaus, J.; Gruwe, M.; Hanson, G.G.; Hansroul, M.; Hapke, M.; Harder, K.; Harel, A.; Hargrove, C.K.; Hartmann, C.; Hauschild, M.; Hawkes, C.M.; Hawkings, R.; Hemingway, R.J.; Herndon, M.; Herten, G.; Heuer, R.D.; Hildreth, M.D.; Hill, J.C.; Hobson, P.R.; Hoch, M.; Hocker, James Andrew; Hoffman, Kara Dion; Homer, R.J.; Honma, A.K.; Horvath, D.; Hossain, K.R.; Howard, R.; Huntemeyer, P.; Igo-Kemenes, P.; Imrie, D.C.; Ishii, K.; Jacob, F.R.; Jawahery, A.; Jeremie, H.; Jimack, M.; Jones, C.R.; Jovanovic, P.; Junk, T.R.; Karlen, D.; Kartvelishvili, V.; Kawagoe, K.; Kawamoto, T.; Kayal, P.I.; Keeler, R.K.; Kellogg, R.G.; Kennedy, B.W.; Kim, D.H.; Klier, A.; Kluth, S.; Kobayashi, T.; Kobel, M.; Koetke, D.S.; Kokott, T.P.; Kolrep, M.; Komamiya, S.; Kowalewski, Robert V.; Kress, T.; Krieger, P.; von Krogh, J.; Kuhl, T.; Kyberd, P.; Lafferty, G.D.; Landsman, H.; Lanske, D.; Lauber, J.; Lautenschlager, S.R.; Lawson, I.; Layter, J.G.; Lazic, D.; Lee, A.M.; Lellouch, D.; Letts, J.; Levinson, L.; Liebisch, R.; List, B.; Littlewood, C.; Lloyd, A.W.; Lloyd, S.L.; Loebinger, F.K.; Long, G.D.; Losty, M.J.; Ludwig, J.; Lui, D.; Macchiolo, A.; Macpherson, A.; Mader, W.; Mannelli, M.; Marcellini, S.; Markopoulos, C.; Martin, A.J.; Martin, J.P.; Martinez, G.; Mashimo, T.; Mattig, Peter; McDonald, W.John; McKenna, J.; Mckigney, E.A.; McMahon, T.J.; McPherson, R.A.; Meijers, F.; Menke, S.; Merritt, F.S.; Mes, H.; Meyer, J.; Michelini, A.; Mihara, S.; Mikenberg, G.; Miller, D.J.; Mir, R.; Mohr, W.; Montanari, A.; Mori, T.; Nagai, K.; Nakamura, I.; Neal, H.A.; Nellen, B.; Nisius, R.; O'Neale, S.W.; Oakham, F.G.; Odorici, F.; Ogren, H.O.; Oreglia, M.J.; Orito, S.; Palinkas, J.; Pasztor, G.; Pater, J.R.; Patrick, G.N.; Patt, J.; Perez-Ochoa, R.; Petzold, S.; Pfeifenschneider, P.; Pilcher, J.E.; Pinfold, J.; Plane, David E.; Poffenberger, P.; Polok, J.; Przybycien, M.; Rembser, C.; Rick, H.; Robertson, S.; Robins, S.A.; Rodning, N.; Roney, J.M.; Roscoe, K.; Rossi, A.M.; Rozen, Y.; Runge, K.; Runolfsson, O.; Rust, D.R.; Sachs, K.; Saeki, T.; Sahr, O.; Sang, W.M.; Sarkisian, E.K.G.; Sbarra, C.; Schaile, A.D.; Schaile, O.; Scharf, F.; Scharff-Hansen, P.; Schieck, J.; Schmitt, B.; Schmitt, S.; Schoning, A.; Schroder, Matthias; Schumacher, M.; Schwick, C.; Scott, W.G.; Seuster, R.; Shears, T.G.; Shen, B.C.; Shepherd-Themistocleous, C.H.; Sherwood, P.; Siroli, G.P.; Sittler, A.; Skuja, A.; Smith, A.M.; Snow, G.A.; Sobie, R.; Soldner-Rembold, S.; Spagnolo, S.; Sproston, M.; Stahl, A.; Stephens, K.; Steuerer, J.; Stoll, K.; Strom, David M.; Strohmer, R.; Surrow, B.; Talbot, S.D.; Tanaka, S.; Taras, P.; Tarem, S.; Teuscher, R.; Thiergen, M.; Thomas, J.; Thomson, M.A.; von Torne, E.; Torrence, E.; Towers, S.; Trigger, I.; Trocsanyi, Z.; Tsur, E.; Turcot, A.S.; Turner-Watson, M.F.; Ueda, I.; Van Kooten, Rick J.; Vannerem, P.; Verzocchi, M.; Voss, H.; Wackerle, F.; Wagner, A.; Ward, C.P.; Ward, D.R.; Watkins, P.M.; Watson, A.T.; Watson, N.K.; Wells, P.S.; Wermes, N.; White, J.S.; Wilson, G.W.; Wilson, J.A.; Wyatt, T.R.; Yamashita, S.; Yekutieli, G.; Zacek, V.; Zer-Zion, D.

    1999-01-01

    Searches for pair-produced charginos and neutralinos with R-parity violating decays have been performed using a data sample corresponding to an integrated luminosity of 56 pb-1 collected with the OPAL detector at LEP at a centre-of-mass energy of 183 GeV. An important consequence of R-parity violation is that the lightest supersymmetric particle becomes unstable. The searches have been performed under the assumptions that the lightest supersymmetric particle promptly decays and that only one R-parity violating coupling is dominant for each of the decay modes considered. Such processes would yield multiple leptons, leptons plus jets, or multiple jets with or without significant missing energy in the final state. No excess of such events above Standard Model backgrounds has been observed. Limits are presented on the production cross-sections of gauginos in R-parity violating scenarios. Limits are also presented in the framework of the Minimal Supersymmetric Standard Model.

  10. Data Preservation, Information Preservation, and Lifecyle of Information Management at NASA GES DISC

    Science.gov (United States)

    Khayat, Mo; Kempler, Steve; Deshong, Barbara; Johnson, James; Gerasimov, Irina; Esfandiari, Ed; Berganski, Michael; Wei, Jennifer

    2014-01-01

    Data lifecycle management awareness is common today; planners are more likely to consider lifecycle issues at mission start. NASA remote sensing missions are typically subject to life cycle management plans of the Distributed Active Archive Center (DAAC), and NASA invests in these national centers for the long-term safeguarding and benefit of future generations. As stewards of older missions, it is incumbent upon us to ensure that a comprehensive enough set of information is being preserved to prevent the risk for information loss. This risk is greater when the original data experts have moved on or are no longer available. Preservation of items like documentation related to processing algorithms, pre-flight calibration data, or input-output configuration parameters used in product generation, are examples of digital artifacts that are sometimes not fully preserved. This is the grey area of information preservation; the importance of these items is not always clear and requires careful consideration. Missing important metadata about intermediate steps used to derive a product could lead to serious challenges in the reproducibility of results or conclusions. Organizations are rapidly recognizing that the focus of life-cycle preservation needs to be enlarged from the strict raw data to the more encompassing arena of information lifecycle management. By understanding what constitutes information, and the complexities involved, we are better equipped to deliver longer lasting value about the original data and derived knowledge (information) from them. The NASA Earth Science Data Preservation Content Specification is an attempt to define the content necessary for long-term preservation. It requires new lifecycle infrastructure approach along with content repositories to accommodate artifacts other than just raw data. The NASA Goddard Earth Sciences Data and Information Services Center (GES DISC) setup an open-source Preservation System capable of long-term archive of

  11. Establishing requirements for information gathering tasks

    NARCIS (Netherlands)

    A.K. Amin (Alia)

    2009-01-01

    htmlabstractThis PhD project aims at understanding and supporting the complex activities of information gathering. To date, most search applications support one aspect of search namely low-level keyword-based search to find documents. However, in reality, users search tasks are often high-level

  12. 'L=R' -- $U(1)_R$ Lepton Number at the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Frugiuele, Claudia [Fermilab; Gregoire, Thomas [Ottawa Carleton Inst. Phys.; Kumar, Piyush [Yale U.; Ponton, Eduardo [ISCAP, New York

    2013-05-03

    We perform a detailed study of a variety of LHC signals in supersymmetric models where lepton number is promoted to an (approximate) U(1)( )R( ) symmetry. Such a symmetry has interesting implications for naturalness, as well as flavor- and CP-violation, among others. Interestingly, it makes large sneutrino vacuum expectation values phenomenologically viable, so that a slepton doublet can play the role of the down-type Higgs. As a result, (some of) the leptons and neutrinos are incorporated into the chargino and neutralino sectors. This leads to characteristic decay patterns that can be experimentally tested at the LHC. The corresponding collider phenomenology is largely determined by the new approximately conserved quantum number, which is itself closely tied to the presence of “leptonic R-parity violation”. We find rather loose bounds on the first and second generation squarks, arising from a combination of suppressed production rates together with relatively small signal efficiencies of the current searches. Naturalness would indicate that such a framework should be discovered in the near future, perhaps through spectacular signals exhibiting the lepto-quark nature of the third generation squarks. The presence of fully visible decays, in addition to decay chains involving large missing energy (in the form of neutrinos) could give handles to access the details of the spectrum of new particles, if excesses over SM background were to be observed. The scale of neutrino masses is intimately tied to the source of U(1)( )R( ) breaking, thus opening a window into the R-breaking sector through neutrino physics. Further theoretical aspects of the model have been presented in the companion paper [1].

  13. USER REQUIREMENTS GATHERING FOR 3D GEOGRAPHIC INFORMATION IN THE UNITED KINGDOM

    Directory of Open Access Journals (Sweden)

    K. Wong

    2017-10-01

    Full Text Available Despite significant developments, 3D technologies are still not fully exploited in practice due to the lack of awareness as well as the lack of understanding of who the users of 3D will be and what the user requirements are. From a National Mapping & Cadastral Agency and data acquisition perspective, each new 3D feature type and element within a feature added (such as doors, windows, chimneys, street lights requires additional processing and cost to create. There is therefore a need to understand the importance of different 3D features and components for different applications. This will allow the direction of capture effort towards items that will be relevant to a wide range of users, as well as to understand the current status of, and interest in, 3D at a national level. This paper reports the results of an initial requirements gathering exercise for 3D geographic information in the United Kingdom (UK. It describes a user-centred design approach where usability and user needs are given extensive attention at each stage of the design process. Web-based questionnaires and semi-structured face-to-face interviews were used as complementary data collection methods to understand the user needs. The results from this initial study showed that while some applications lead the field with a high adoption of 3D, others are laggards, predominantly from organisational inertia. While individuals may be positive about the use of 3D, many struggle to justify the value and business case for 3D GI. Further work is required to identify the specific geometric and semantic requirements for different applications and to repeat the study with a larger sample.

  14. User Requirements Gathering for 3d Geographic Information in the United Kingdom

    Science.gov (United States)

    Wong, K.; Ellul, C.

    2017-10-01

    Despite significant developments, 3D technologies are still not fully exploited in practice due to the lack of awareness as well as the lack of understanding of who the users of 3D will be and what the user requirements are. From a National Mapping & Cadastral Agency and data acquisition perspective, each new 3D feature type and element within a feature added (such as doors, windows, chimneys, street lights) requires additional processing and cost to create. There is therefore a need to understand the importance of different 3D features and components for different applications. This will allow the direction of capture effort towards items that will be relevant to a wide range of users, as well as to understand the current status of, and interest in, 3D at a national level. This paper reports the results of an initial requirements gathering exercise for 3D geographic information in the United Kingdom (UK). It describes a user-centred design approach where usability and user needs are given extensive attention at each stage of the design process. Web-based questionnaires and semi-structured face-to-face interviews were used as complementary data collection methods to understand the user needs. The results from this initial study showed that while some applications lead the field with a high adoption of 3D, others are laggards, predominantly from organisational inertia. While individuals may be positive about the use of 3D, many struggle to justify the value and business case for 3D GI. Further work is required to identify the specific geometric and semantic requirements for different applications and to repeat the study with a larger sample.

  15. 76 FR 15055 - Proposed Information Collection (Requirements for Interest Rate Reduction Refinancing Loans...

    Science.gov (United States)

    2011-03-18

    ... (Requirements for Interest Rate Reduction Refinancing Loans); Comment Request AGENCY: Veterans Benefits... to refinance a delinquent VA-guaranteed loan with a lower interest rate. DATES: Written comments and... techniques or the use of other forms of information technology. Title: Requirements for Interest Rate...

  16. Performance assessment and beamline diagnostics based on evaluation of temporal information from infrared spectral datasets by means of R Environment for statistical analysis.

    Science.gov (United States)

    Banas, Krzysztof; Banas, Agnieszka; Gajda, Mariusz; Kwiatek, Wojciech M; Pawlicki, Bohdan; Breese, Mark B H

    2014-07-15

    Assessment of the performance and up-to-date diagnostics of scientific equipment is one of the key components in contemporary laboratories. Most reliable checks are performed by real test experiments while varying the experimental conditions (typically, in the case of infrared spectroscopic measurements, the size of the beam aperture, the duration of the experiment, the spectral range, the scanner velocity, etc.). On the other hand, the stability of the instrument response in time is another key element of the great value. Source stability (or easy predictable temporal changes, similar to those observed in the case of synchrotron radiation-based sources working in non top-up mode), detector stability (especially in the case of liquid nitrogen- or liquid helium-cooled detectors) should be monitored. In these cases, recorded datasets (spectra) include additional variables such as time stamp when a particular spectrum was recorded (in the case of time trial experiments). A favorable approach in evaluating these data is building hyperspectral object that consist of all spectra and all additional parameters at which these spectra were recorded. Taking into account that these datasets could be considerably large in size, there is a need for the tools for semiautomatic data evaluation and information extraction. A comprehensive R archive network--the open-source R Environment--with its flexibility and growing potential, fits these requirements nicely. In this paper, examples of practical implementation of methods available in R for real-life Fourier transform infrared (FTIR) spectroscopic data problems are presented. However, this approach could easily be adopted to many various laboratory scenarios with other spectroscopic techniques.

  17. What are we eating? Consumer information requirement within a workplace canteen

    DEFF Research Database (Denmark)

    Price, Sarah; Viglia, Giampaolo; Hartwell, Heather

    2016-01-01

    The workplace is a captive environment where the overall contribution of the meal served could be an important element of the overall diet. Despite growing demand little information is available to aid healthy dish selection. This study identifies information valued by consumers in the UK, Greece......, Denmark and France using best-worst scaling. Value for Money, Nutrition and Naturalness are key elements of information that consumers require to be able to make a conscious decision about dish selection in all four countries. Latent class analysis shows that consumers align to one of five cluster groups......, i.e., Value Driven, Conventionalists, Socially Responsible, Health Conscious and Locavores. Understanding key information needs can allow food operators to align their service with consumer preferences across different market segments....

  18. At R807

    CERN Multimedia

    1982-01-01

    The photo shows (centre) the newly installed muon filter of R807. The Open Axial Field magnet can be seen on the left-hand side with the central drift chamber in position around the beam crossing. The vertical wall of uranium calorimeters is withdrawn for access, and behind it can be seen the iron shielding blocks and finally the proportional chambers aqnd atmospheric Cerenkov counters which provide the muon detection. (See Annual Report 1982 p. 109, Fig. 5).

  19. 78 FR 52963 - 60-Day Notice of Proposed Information Collection: Technical Processing Requirements for...

    Science.gov (United States)

    2013-08-27

    ... Information Collection: Technical Processing Requirements for Multifamily Project Mortgage Insurance AGENCY...: HUD is seeking approval from the Office of Management and Budget (OMB) for the information collection... interested parties on the proposed collection of information. The purpose of this notice is to allow for 60...

  20. Medicaid management information systems performance standards: Health Care Financing Administration. Notice with comment period.

    Science.gov (United States)

    1981-06-30

    This notice contains performance standards (review elements and factors). We are required by section 1903(r)(6)(E) of the Social Security Act to notify all States of proposed procedures, standards, and other requirements at least one quarter prior to the fiscal year in which the procedures, standards, and other requirements will be used for Medicaid Management Information Systems reapproval reviews. This Notice meets that statutory requirements. By October 1, 1981, we will use the performance standards and existing systems requirements when conducting the annual review of State system performance.

  1. 77 FR 67366 - Federal Acquisition Regulation; Information Collection; Quality Assurance Requirements

    Science.gov (United States)

    2012-11-09

    .... Glover, Sr., Procurement Analyst, Contract Policy Division, GSA (202) 501-1448 or email [email protected] . SUPPLEMENTARY INFORMATION: A. Purpose Supplies and services acquired under Government contracts..., acceptance, warranty, and other measures associated with quality requirements. Standard clauses related to...

  2. 78 FR 63462 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement...

    Science.gov (United States)

    2013-10-24

    ... Relating to Organizational Conflict of Interest-Major Defense Acquisition Program; OMB Control Number 0704...] Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Organizational Conflict... submit comments, identified by OMB Control Number 0704-0477, using any of the following methods: [cir...

  3. Performance of R-GMA based grid job monitoring system for CMS data production

    CERN Document Server

    Byrom, Robert; Fisher, Steve M; Grandi, Claudio; Hobson, Peter R; Kyberd, Paul; MacEvoy, Barry; Nebrensky, Jindrich Josef; Tallini, Hugh; Traylen, Stephen

    2004-01-01

    High Energy Physics experiments, such as the Compact Muon Solenoid (CMS) at the CERN laboratory in Geneva, have large-scale data processing requirements, with stored data accumulating at a rate of 1 Gbyte/s. This load comfortably exceeds any previous processing requirements and we believe it may be most efficiently satisfied through Grid computing. Management of large Monte Carlo productions (~3000 jobs) or data analyses and the quality assurance of the results requires careful monitoring and bookkeeping, and an important requirement when using the Grid is the ability to monitor transparently the large number of jobs that are being executed simultaneously at multiple remote sites. R-GMA is a monitoring and information management service for distributed resources based on the Grid Monitoring Architecture of the Global Grid Forum. We have previously developed a system allowing us to test its performance under a heavy load while using few real Grid resources. We present the latest results on this system and comp...

  4. Requirements management at Westinghouse Electric Company

    International Nuclear Information System (INIS)

    Gustavsson, Henrik

    2014-01-01

    Field studies and surveys made in various industry branches support the Westinghouse opinion that qualitative systems engineering and requirements management have a high value in the development of complex systems and products. Two key issues causing overspending and schedule delays in projects are underestimation of complexity and misunderstandings between the different sub-project teams. These issues often arise when a project jumps too early into detail design. Good requirements management practice before detail design helps the project teams avoid such issues. Westinghouse therefore puts great effort into requirements management. The requirements management methodology at Westinghouse rests primarily on four key cornerstones: 1 - Iterative team work when developing requirements specifications, 2 - Id number tags on requirements, 3 - Robust change routine, and 4 - Requirements Traceability Matrix. (authors)

  5. Impact of Requirements Elicitation Processes on Success of Information System Development Projects

    Directory of Open Access Journals (Sweden)

    Bormane Līga

    2016-12-01

    Full Text Available Requirements articulating user needs and corresponding to enterprise business processes are a key to successful implementation of information system development projects. However, the parties involved in projects frequently are not able to agree on a common development vision and have difficulties expressing their needs. Several industry experts have acknowledged that requirements elicitation is one of the most difficult tasks in development projects. This study investigates the impact of requirements elicitation processes on project outcomes depending on the applied project development methodology.

  6. Scalability tests of R-GMA based Grid job monitoring system for CMS Monte Carlo data production

    CERN Document Server

    Bonacorsi, D; Field, L; Fisher, S; Grandi, C; Hobson, P R; Kyberd, P; MacEvoy, B; Nebrensky, J J; Tallini, H; Traylen, S

    2004-01-01

    High Energy Physics experiments such as CMS (Compact Muon Solenoid) at the Large Hadron Collider have unprecedented, large-scale data processing computing requirements, with data accumulating at around 1 Gbyte/s. The Grid distributed computing paradigm has been chosen as the solution to provide the requisite computing power. The demanding nature of CMS software and computing requirements, such as the production of large quantities of Monte Carlo simulated data, makes them an ideal test case for the Grid and a major driver for the development of Grid technologies. One important challenge when using the Grid for large-scale data analysis is the ability to monitor the large numbers of jobs that are being executed simultaneously at multiple remote sites. R-GMA is a monitoring and information management service for distributed resources based on the Grid Monitoring Architecture of the Global Grid Forum. In this paper we report on the first measurements of R-GMA as part of a monitoring architecture to be used for b...

  7. Geostationary Operational Environmental Satellites (GOES): R series hyperspectral environmental suite (HES) overview

    Science.gov (United States)

    Martin, Gene; Criscione, Joseph C.; Cauffman, Sandra A.; Davis, Martin A.

    2004-11-01

    The Hyperspectral Environmental Suite (HES) instrument is currently under development by the NASA GOES-R Project team within the framework of the GOES Program to fulfill the future needs and requirements of the National Environmental Satellite, Data, and Information Service (NESDIS) Office. As part of the GOES-R instrument complement, HES will provide measurements of the traditional temperature and water vapor vertical profiles with higher accuracy and vertical resolution than obtained through current sounder technologies. HES will provide measurements of the properties of the shelf and coastal waters and back up imaging (at in-situ resolution) for the GOES-R Advanced Baseline Imager (ABI). The HES team is forging the future of remote environmental monitoring with the development of an operational instrument with high temporal, spatial and spectral-resolution and broad hemispheric coverage. The HES development vision includes threshold and goal requirements that encompass potential system solutions. The HES team has defined tasks for the instrument(s) that include a threshold functional complement of Disk Sounding (DS), Severe Weather/Mesoscale Sounding (SW/M), and Shelf and Coastal Waters imaging (CW) and a goal functional complement of Open Ocean (OO) imaging, and back up imaging (at in-situ resolution) for the GOES-R Advanced Baseline Imager (ABI). To achieve the best-value procurement, the GOES-R Project has base-lined a two-phase procurement approach to the HES design and development; a Formulation/study phase and an instrument Implementation phase. During Formulation, currently slated for the FY04-05 timeframe, the developing team(s) will perform Systems Requirements Analysis and evaluation, System Trade and Requirements Baseline Studies, Risk Assessment and Mitigation Strategy and complete a Preliminary Conceptual Design of the HES instrument. The results of the formulation phase will be leveraged to achieve an effective and efficient system solution during

  8. Information processing requirements for on-board monitoring of automatic landing

    Science.gov (United States)

    Sorensen, J. A.; Karmarkar, J. S.

    1977-01-01

    A systematic procedure is presented for determining the information processing requirements for on-board monitoring of automatic landing systems. The monitoring system detects landing anomalies through use of appropriate statistical tests. The time-to-correct aircraft perturbations is determined from covariance analyses using a sequence of suitable aircraft/autoland/pilot models. The covariance results are used to establish landing safety and a fault recovery operating envelope via an event outcome tree. This procedure is demonstrated with examples using the NASA Terminal Configured Vehicle (B-737 aircraft). The procedure can also be used to define decision height, assess monitoring implementation requirements, and evaluate alternate autoland configurations.

  9. Can R-parity violation hide vanilla supersymmetry at the LHC?

    International Nuclear Information System (INIS)

    Asano, Masaki

    2012-09-01

    Current experimental constraints on a large parameter space in supersymmetric models rely on the large missing energy signature. This is usually provided by the lightest neutralino which stability is ensured by the R-parity. However, if the R-parity is violated, the lightest neutralino decays into the standard model particles and the missing energy cut is not efficient anymore. In particular, the UDD type R-parity violation induces the neutralino decay to three quarks which potentially leads to the most difficult signal to be searched at hadron colliders. In this paper, we study the constraints on the R-parity violating supersymmetric models using a same-sign dilepton and a multijet signatures. We show that the gluino and squarks lighter than a TeV are already excluded in constrained minimal supersymmetric standard model with R-parity violation if their masses are approximately equal. We also analyze constraints in a simplified model with R-parity violation. We compare how R-parity violation changes some of the observables typically used to distinguish a supersymmetric signal from standard model backgrounds.

  10. Can R-parity violation hide vanilla supersymmetry at the LHC?

    Energy Technology Data Exchange (ETDEWEB)

    Asano, Masaki [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik; Rolbiecki, Krzysztof; Sakurai, Kazuki [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2012-09-15

    Current experimental constraints on a large parameter space in supersymmetric models rely on the large missing energy signature. This is usually provided by the lightest neutralino which stability is ensured by the R-parity. However, if the R-parity is violated, the lightest neutralino decays into the standard model particles and the missing energy cut is not efficient anymore. In particular, the UDD type R-parity violation induces the neutralino decay to three quarks which potentially leads to the most difficult signal to be searched at hadron colliders. In this paper, we study the constraints on the R-parity violating supersymmetric models using a same-sign dilepton and a multijet signatures. We show that the gluino and squarks lighter than a TeV are already excluded in constrained minimal supersymmetric standard model with R-parity violation if their masses are approximately equal. We also analyze constraints in a simplified model with R-parity violation. We compare how R-parity violation changes some of the observables typically used to distinguish a supersymmetric signal from standard model backgrounds.

  11. Collaborative Product Development in an R&D Environment

    Science.gov (United States)

    Davis, Jose M.; Keys, L. Ken; Chen, Injazz J.; Peterson, Paul L.

    2004-01-01

    Research and development (R&D) organizations are being required to be relevant, to be more application-oriented, and to be partners in the strategic management of the business while meeting the same challenges as the rest of the organization, namely: (1) reduced time to market; (2) reduced cost; (3) improved quality; (4) increased reliability; and (5) increased focus on customer needs. Recent advances in computer technology and the Internet have created a new paradigm of collaborative engineering or collaborative product development (CPD), from which new types of relationships among researchers and their partners have emerged. Research into the applicability and benefits of CPD in a low/no production, R&D, and/or government environment is limited. In addition, the supply chain management (SCM) aspects of these relationships have not been studied. This paper presents research conducted at the NASA Glenn Research Center (GRC) investigating the applicability of CPD and SCM in an R&D organization. The study concentrates on the management and implementation of space research activities at GRC. Results indicate that although the organization is engaged in collaborative relationships that incorporate aspects of SCM, a number of areas, such as development of trust and information sharing merit special attention.

  12. MODIS information, data and control system (MIDACS) level 2 functional requirements

    Science.gov (United States)

    Han, D.; Salomonson, V.; Ormsby, J.; Sharts, B.; Folta, D.; Ardanuy, P.; Mckay, A.; Hoyt, D.; Jaffin, S.; Vallette, B.

    1988-01-01

    The MODIS Information, Data and Control System (MIDACS) Level 2 Functional Requirements Document establishes the functional requirements for MIDACS and provides a basis for the mutual understanding between the users and the designers of the EosDIS, including the requirements, operating environment, external interfaces, and development plan. In defining the requirements and scope of the system, this document describes how MIDACS will operate as an element of the EOS within the EosDIS environment. This version of the Level 2 Requirements Document follows an earlier release of a preliminary draft version. The sections on functional and performance requirements do not yet fully represent the requirements of the data system needed to achieve the scientific objectives of the MODIS instruments and science teams. Indeed, the team members have not yet been selected and the team has not yet been formed; however, it has been possible to identify many relevant requirements based on the present concept of EosDIS and through interviews and meetings with key members of the scientific community. These requirements have been grouped by functional component of the data system, and by function within each component. These requirements have been merged with the complete set of Level 1 and Level 2 context diagrams, data flow diagrams, and data dictionary.

  13. Damping Ring R&D at CESR-TA

    Energy Technology Data Exchange (ETDEWEB)

    Rubin, David L. [Cornell Univ., Ithaca, NY (United States). Dept. of Physics

    2015-01-23

    , and that an instability associated with residual gas in the beam pipe would limit the intensity of the electron ring. It was also not clear whether the required very small beam size could be achieved. The results of this study are important contributions to the design of both the electron and positron damping rings in which all of those challenges are addressed and overcome. Our findings are documented in the ILC Technical Design Report, a document that represents the work of an international collaboration of scientists. Our contributions include design of the beam magnetic optics for the 3 km circumference damping rings, the vacuum system and surface treatments for electron cloud mitigation, the design of the guide field magnets, design of the superconducting damping wigglers, and new detectors for precision measurement of beam properties. Our study informed the specification of the basic design parameters for the damping rings, including alignment tolerances, magnetic field errors, and instrumentation. We developed electron cloud modelling tools and simulations to aid in the interpretation of the measurements that we carried out in the Cornell Electron-positron Storage Ring (CESR). The simulations provide a means for systematic extrapolation of our measurements at CESR to the proposed ILC damping rings, and ultimately to specify how the beam pipes should be fabricated in order to minimize the effects of the electron cloud. With the conclusion of this study, the design of the essential components of the damping rings is complete, including the development and characterization (with computer simulations) of the beam optics, specification of techniques for minimizing beam size, design of damping ring instrumentation, R&D into electron cloud suppression methods, tests of long term durability of electron cloud coatings, and design of damping ring vacuum system components.

  14. A.C.R.O. activity report 2001

    International Nuclear Information System (INIS)

    2001-01-01

    As regards the environmental protection, the A.C.R.O. maintained in 2001 its programs of surveillance around the main western nuclear installations of France. The radioecological surveillance of the site of Cogema La-Hague for the dismantling of the former pipe of release in sea was one of the key points of this action environmental surveillance. The two accidents of atmospheric release in may and october 2001 at Cogema La Hague have shown the interest of an association as A.C.R.O.. It is thank to the measure, by our laboratory, of repercussions on environment of these incidents that it has been possible to bring to light a dysfunction of the measurement system of the gaseous effluents released by the facility operator. To improve the public information, A.C.R.O. concerns its main efforts on the development of the consumer technical information available on-line via its web site and in its regular publication 'the nuclear chronicle'. Besides, the participation of the A.C.R.O. to the radioecology North Cotentin group (within the framework of the continuation of its mission) but also at various local commissions of information (C.L.I.) as well as at the superior council of the safety and nuclear information ( C.S.S.I.N.) stays an essential action. Concerning the environmental protection, the A.C.R.O. maintains its programs of surveillance around the nuclear facilities of La Hague and Chinon and continues the surveillance of the site of Cogema La hague as regards the new pipe of release in sea. Among the new commitments for 2000, the participation to the radioecology North Cotentin group in the framework of the continuation of its mission and the participation to the international intercomparison 'N.O.R.C.O. 2000' punctuated the year. (N.C.)

  15. IQM-Reifegradmodell für die Bewertung und Verbesserung des Information Lifecycle Management Prozesses

    Science.gov (United States)

    Baškarada, Saša; Gebauer, Marcus; Koronios, Andy; Gao, Jing

    Heutige Organisationen produzieren und speichern mehr Informationen als je zuvor. Der resultierende Informationsüberfluss, zusammen mit einem Mangel an Qualitätssicherung für das Information Lifecycle Management, führt zu einem unsicheren Status der Informationsqualität in vielen Organisationen. Weiterhin hat sich herausgestellt, dass das Bewerten, Verbessern und Steuern der Informationsqualität ein offenkundig schwieriges Unterfangen ist. Dieses Kapitel stellt ein Modell zur Bewertung und Verbesserung der Information Quality Management Capability Maturity (IQM-Reifegrad) vor. Es wird ein Satz von Kriterien vorgestellt, der aus Literaturrecherche und Fallstudien abgeleitet wurde. Die Reifegradindikatoren werden validiert und in einem mehrstufigen Reifegradmodell durch eine Delphi-Studie gruppiert. Das abgeleitete IQM-Reifegradmodell hilft Organisationen ihre bestehenden Praktiken im IQM zu bewerten und potentielle Lücken und Verbesserungsstrategien zu ermitteln.

  16. Det Digitale Nærvær

    DEFF Research Database (Denmark)

    Heilesen, Simon

    Computer-medieret kommunikation (CMC – via intranet- og internet, ”allestedsnærværende computing” mm. ), er grundlaget for det informations- og videnssamfund, der begynder at tage form i disse år. CMC er blevet kolossalt udbredt de seneste 10 – 15 år og har forandret den måde vi udsender og søger...... information, kommunikerer med hinanden både privat og i organisationer, samarbejder, underviser og tilegner os viden. Denne bog går tæt på tre udvalgte områder inden for den computer-medierede kommunikation: · Videndeling i formelle og uformelle organisationer, · Netbaseret samarbejde og læring, · Design af...

  17. The GlnR Regulon in Streptococcus mutans Is Differentially Regulated by GlnR and PmrA.

    Directory of Open Access Journals (Sweden)

    Yi-Ywan M Chen

    Full Text Available GlnR-mediated repression of the GlnR regulon at acidic pH is required for optimal acid tolerance in Streptococcus mutans, the etiologic agent for dental caries. Unlike most streptococci, the GlnR regulon is also regulated by newly identified PmrA (SMUGS5_RS05810 at the transcriptional level in S. mutans GS5. Results from gel mobility shift assays confirmed that both GlnR and PmrA recognized the putative GlnR box in the promoter regions of the GlnR regulon genes. By using a chemostat culture system, we found that PmrA activated the expression of the GlnR regulon at pH 7, and that this activation was enhanced by excess glucose. Deletion of pmrA (strain ΔPmrA reduced the survival rate of S. mutans GS5 at pH 3 moderately, whereas the GlnR mutant (strain ΔGlnR exhibited an acid-sensitive phenotype in the acid killing experiments. Elevated biofilm formation in both ΔGlnR and ΔPmrA mutant strains is likely a result of indirect regulation of the GlnR regulon since GlnR and PmrA regulate the regulon differently. Taken together, it is suggested that activation of the GlnR regulon by PmrA at pH 7 ensures adequate biosynthesis of amino acid precursor, whereas repression by GlnR at acidic pH allows greater ATP generation for acid tolerance. The tight regulation of the GlnR regulon in response to pH provides an advantage for S. mutans to better survive in its primary niche, the oral cavity.

  18. SAVANNAH RIVER SITE R-REACTOR DISASSEMBLY BASIN IN-SITU DECOMMISSIONING -10499

    Energy Technology Data Exchange (ETDEWEB)

    Langton, C.; Serrato, M.; Blankenship, J.; Griffin, W.

    2010-01-04

    The US DOE concept for facility in-situ decommissioning (ISD) is to physically stabilize and isolate intact, structurally sound facilities that are no longer needed for their original purpose, i.e., generating (reactor facilities), processing(isotope separation facilities) or storing radioactive materials. The 105-R Disassembly Basin is the first SRS reactor facility to undergo the in-situ decommissioning (ISD) process. This ISD process complies with the 105-R Disassembly Basin project strategy as outlined in the Engineering Evaluation/Cost Analysis for the Grouting of the R-Reactor Disassembly Basin at the Savannah River Site and includes: (1) Managing residual water by solidification in-place or evaporation at another facility; (2) Filling the below grade portion of the basin with cementitious materials to physically stabilize the basin and prevent collapse of the final cap - Sludge and debris in the bottom few feet of the basin will be encapsulated between the basin floor and overlying fill material to isolate it from the environment; (3) Demolishing the above grade portion of the structure and relocating the resulting debris to another location or disposing of the debris in-place; and (4) Capping the basin area with a concrete slab which is part of an engineered cap to prevent inadvertent intrusion. The estimated total grout volume to fill the 105-R Reactor Disassembly Basin is 24,384 cubic meters or 31,894 cubic yards. Portland cement-based structural fill materials were designed and tested for the reactor ISD project, and a placement strategy for stabilizing the basin was developed. Based on structural engineering analyses and material flow considerations, maximum lift heights and differential height requirements were determined. Pertinent data and information related to the SRS 105-R Reactor Disassembly Basin in-situ decommissioning include: regulatory documentation, residual water management, area preparation activities, technology needs, fill material

  19. Appraisal of Information Technology Requirements in Quantity Surveying Firms in Northern Nigeria

    Directory of Open Access Journals (Sweden)

    Y. U. Datti

    2017-06-01

    Full Text Available A worrisome trend in the adoption of emerging technologies for competitive advantages and improved productivities by QSs have been observed in that there is overwhelming evidence that there is an increasing usage of IT in quantity surveying firms but little or no noticeable benefits on the practice. It however becomes pertinent to ask then, that despite the increases adoption of computing and telecommunication technologies, why isn’t there any noticeable change due to the impacts of IT in the Nigerian Construction Industry with particular reference to Quantity Surveying practices. The study appraised the requirement of IT in quantity surveying practice in Nigeria. It examined the position of IT in quantity surveying firms in terms of its requirement and analyzed IT requirements-based problem constraining quantity surveying firms. The study is a survey research designed to obtain information on information technology in QS firms. A self-administered questionnaire was employed to quantity surveyors in consulting firms for responses. Responses were returned and analyzed using severity index and later ranked in order of importance. The results indicate a high level of computerization of professional services among the firms with greater number of their computers being networked. However, despite high level of networking of available computers, sharing of printers and other scarce tools/technologies are not established. Compared to developed countries such as Canada, Australia, United Kingdom and USA, the position of IT requirements in QS firms in Nigeria can be said to be at basic level with organization possessing and applying basic IT tools and technologies (e.g. scanners, digital cameras, dvd/cd-rom, general purpose software, QS application software, chat programs etc. in their daily operation and processes. While most firms are progressing toward intermediate level by possessing intermediate IT tools and technologies (e.g. teleconferencing

  20. 78 FR 77660 - Proposed Extension of Approval of Information Collection; Comment Request-Safety Standards for...

    Science.gov (United States)

    2013-12-24

    ... 30.6 percent for benefits brings average hourly compensation for a mid-range salaried GS-12 employee... literature that fall within the definition of ``collections of information'' at 5 C.F.R. Sec. 1320.3(c... requirements for marking, labeling, and instructional literature that [[Page 77661

  1. Review of Regulatory Quality Assurance Requirements for the Operation of Nuclear R and D Facilities

    International Nuclear Information System (INIS)

    Kwon, Hyuk Il; Lim, Nam Jin

    2005-01-01

    Korea Atomic Energy Research Institute (KAERI) has many R and D facilities in operation, including HANARO research reactor, radioactive waste treatment facility (RWTF), post-irradiation examination facility (PIEF) and irradiated material test facility (IMEF). Recently, nation-wide interest is focused on the safety and security of major industrial facilities. Safe operation of nuclear facilities is imperative because of the consequence of public disaster by radiological release/ contamination, in case of an accident. Recently, Ministry of Science and Technology (MOST) of the Korean government announced amendments of Atomic Energy laws to enforce requirements of the physical protection and radiological emergency. In this paper, the context of amended Atomic Energy laws were reviewed to confirm quality assurance measures and identify additional QA activities, if any, that is required by the amendment

  2. 77 FR 70970 - Accessible Emergency Information, and Apparatus Requirements for Emergency Information and Video...

    Science.gov (United States)

    2012-11-28

    ... and better access video programming.'' H.R. Rep. No. 111-563, 111th Cong., 2d Sess. at 19 (2010... distributors, providers, and owners of television video programming, as well as the manufacturers of devices that display such programming. DATES: Comments are due on or before December 18, 2012; reply comments...

  3. W.R. Grace: Plant Uses Six Sigma Methodology and Traditional Heat Balance Analysis to Identify Energy Conservation Opportunities at Curtis Bay Works

    Energy Technology Data Exchange (ETDEWEB)

    None

    2003-12-01

    The plant-wide energy assessment at W. R. Grace's Curtis Bay Works helped identify four projects with combined potential savings of $840,000 per year. A separate, unique project that would partner W. R. Grace with the City of Baltimore to recover and use landfill gas (methane) to cogenerate steam and electricity was also identified during the assessment. If implemented, the project would recover gas from the landfill to replace 40% of the electricity and 65% of the fuel currently required to produce steam at Curtis Bay Works. Annual savings are estimated at $900,000 to $1.2 million.

  4. Lepton accelerators and radiation sources: R and D investment at BNL

    International Nuclear Information System (INIS)

    Ben-Zvi, I.; Fernow, R.; Gallardo, J.; Hart, M.; Hastings, J.; Johnson, E.; Krinsky, S.; Palmer, R.; Yu, L.H.

    1997-03-01

    Brookhaven National Laboratory (BNL) has shown its determination to remain at the forefront of accelerator based science through its continued investment in long range accelerator R and D. The laboratory has a broad program in accelerator technology development including projects such as high T c magnets at RHIC, Siberian Snakes at the AGS, brightness upgrades on the NSLS storage ring, and spallation source R and D in several departments. This report focuses on a segment of the overall program: the lepton accelerator and coherent radiation source R and D at the laboratory. These efforts are aimed at (1) development of high brightness electron beams, (2) novel acceleration techniques, (3) seeded Free Electron Laser (FEL) development, and (4) R and D for a muon collider. To pursue these objectives, BNL ha over the past decade introduced new organizational arrangements. The BNL Center for Accelerator Physics (CAP) is an interdepartmental unit dedicated to promoting R and D which, cannot be readily conducted within the programs of operating facilities. The Accelerator Test Facility (ATF) is managed by CAP and NSLS as a user facility dedicated to accelerator and beam physics problems of interest to both the High Energy Physics and Basic Energy Sciences programs of the DOE. Capitalizing on these efforts, the Source Development Laboratory (SDL) was established by the NSLS to facilitate coordinated development of sources and experiments to produce and utilize coherent sub-picosecond synchrotron radiation. This White Paper describes the programs being pursued at CAP, ATF and SDL aimed at advancing basic knowledge of lepton accelerators and picosecond radiation sources

  5. Search for R-Parity Violating Decays of Scalar Fermions at LEP

    CERN Document Server

    Abbiendi, G.; Alexander, G.; Allison, John; Altekamp, N.; Anderson, K.J.; Anderson, S.; Arcelli, S.; Asai, S.; Ashby, S.F.; Axen, D.; Azuelos, G.; Ball, A.H.; Barberio, E.; Barlow, Roger J.; Batley, J.R.; Baumann, S.; Bechtluft, J.; Behnke, T.; Bell, Kenneth Watson; Bella, G.; Bellerive, A.; Bentvelsen, S.; Bethke, S.; Betts, S.; Biebel, O.; Biguzzi, A.; Bloodworth, I.J.; Bock, P.; Bohme, J.; Bonacorsi, D.; Boutemeur, M.; Braibant, S.; Bright-Thomas, P.; Brigliadori, L.; Brown, Robert M.; Burckhart, H.J.; Capiluppi, P.; Carnegie, R.K.; Carter, A.A.; Carter, J.R.; Chang, C.Y.; Charlton, David G.; Chrisman, D.; Ciocca, C.; Clarke, P.E.L.; Clay, E.; Cohen, I.; Conboy, J.E.; Cooke, O.C.; Couchman, J.; Couyoumtzelis, C.; Coxe, R.L.; Cuffiani, M.; Dado, S.; Dallavalle, G.Marco; Davis, R.; De Jong, S.; de Roeck, A.; Dervan, P.; Desch, K.; Dienes, B.; Dixit, M.S.; Dubbert, J.; Duchovni, E.; Duckeck, G.; Duerdoth, I.P.; Estabrooks, P.G.; Etzion, E.; Fabbri, F.; Fanfani, A.; Fanti, M.; Faust, A.A.; Fiedler, F.; Fierro, M.; Fleck, I.; Frey, A.; Furtjes, A.; Futyan, D.I.; Gagnon, P.; Gary, J.W.; Gascon-Shotkin, S.M.; Gaycken, G.; Geich-Gimbel, C.; Giacomelli, G.; Giacomelli, P.; Gibson, V.; Gibson, W.R.; Gingrich, D.M.; Glenzinski, D.; Goldberg, J.; Gorn, W.; Grandi, C.; Graham, K.; Gross, E.; Grunhaus, J.; Gruwe, M.; Hajdu, C.; Hanson, G.G.; Hansroul, M.; Hapke, M.; Harder, K.; Harel, A.; Hargrove, C.K.; Harin-Dirac, M.; Hauschild, M.; Hawkes, C.M.; Hawkings, R.; Hemingway, R.J.; Herndon, M.; Herten, G.; Heuer, R.D.; Hildreth, M.D.; Hill, J.C.; Hobson, P.R.; Hocker, James Andrew; Hoffman, Kara Dion; Homer, R.J.; Honma, A.K.; Horvath, D.; Hossain, K.R.; Howard, R.; Huntemeyer, P.; Igo-Kemenes, P.; Imrie, D.C.; Ishii, K.; Jacob, F.R.; Jawahery, A.; Jeremie, H.; Jimack, M.; Jones, C.R.; Jovanovic, P.; Junk, T.R.; Kanaya, N.; Kanzaki, J.; Karlen, D.; Kartvelishvili, V.; Kawagoe, K.; Kawamoto, T.; Kayal, P.I.; Keeler, R.K.; Kellogg, R.G.; Kennedy, B.W.; Kim, D.H.; Klier, A.; Kobayashi, T.; Kobel, M.; Kokott, T.P.; Kolrep, M.; Komamiya, S.; Kowalewski, Robert V.; Kress, T.; Krieger, P.; von Krogh, J.; Kuhl, T.; Kyberd, P.; Lafferty, G.D.; Landsman, H.; Lanske, D.; Lauber, J.; Lawson, I.; Layter, J.G.; Lellouch, D.; Letts, J.; Levinson, L.; Liebisch, R.; List, B.; Littlewood, C.; Lloyd, A.W.; Lloyd, S.L.; Loebinger, F.K.; Long, G.D.; Losty, M.J.; Lu, J.; Ludwig, J.; Lui, D.; Macchiolo, A.; Macpherson, A.; Mader, W.; Mannelli, M.; Marcellini, S.; Martin, A.J.; Martin, J.P.; Martinez, G.; Mashimo, T.; Mattig, Peter; McDonald, W.John; McKenna, J.; Mckigney, E.A.; McMahon, T.J.; McPherson, R.A.; Meijers, F.; Mendez-Lorenzo, P.; Merritt, F.S.; Mes, H.; Michelini, A.; Mihara, S.; Mikenberg, G.; Miller, D.J.; Mohr, W.; Montanari, A.; Mori, T.; Nagai, K.; Nakamura, I.; Neal, H.A.; Nisius, R.; O'Neale, S.W.; Oakham, F.G.; Odorici, F.; Ogren, H.O.; Okpara, A.; Oreglia, M.J.; Orito, S.; Pasztor, G.; Pater, J.R.; Patrick, G.N.; Patt, J.; Perez-Ochoa, R.; Petzold, S.; Pfeifenschneider, P.; Pilcher, J.E.; Pinfold, J.; Plane, David E.; Poffenberger, P.; Poli, B.; Polok, J.; Przybycien, M.; Quadt, A.; Rembser, C.; Rick, H.; Robertson, S.; Robins, S.A.; Rodning, N.; Roney, J.M.; Rosati, S.; Roscoe, K.; Rossi, A.M.; Rozen, Y.; Runge, K.; Runolfsson, O.; Rust, D.R.; Sachs, K.; Saeki, T.; Sahr, O.; Sang, W.M.; Sarkisian, E.K.G.; Sbarra, C.; Schaile, A.D.; Schaile, O.; Scharff-Hansen, P.; Schieck, J.; Schmitt, S.; Schoning, A.; Schroder, Matthias; Schumacher, M.; Schwick, C.; Scott, W.G.; Seuster, R.; Shears, T.G.; Shen, B.C.; Shepherd-Themistocleous, C.H.; Sherwood, P.; Siroli, G.P.; Sittler, A.; Skuja, A.; Smith, A.M.; Snow, G.A.; Sobie, R.; Soldner-Rembold, S.; Spagnolo, S.; Sproston, M.; Stahl, A.; Stephens, K.; Steuerer, J.; Stoll, K.; Strom, David M.; Strohmer, R.; Surrow, B.; Talbot, S.D.; Taras, P.; Tarem, S.; Teuscher, R.; Thiergen, M.; Thomas, J.; Thomson, M.A.; Torrence, E.; Towers, S.; Trigger, I.; Trocsanyi, Z.; Tsur, E.; Turner-Watson, M.F.; Ueda, I.; Van Kooten, Rick J.; Vannerem, P.; Verzocchi, M.; Voss, H.; Wackerle, F.; Wagner, A.; Ward, C.P.; Ward, D.R.; Watkins, P.M.; Watson, A.T.; Watson, N.K.; Wells, P.S.; Wermes, N.; Wetterling, D.; White, J.S.; Wilson, G.W.; Wilson, J.A.; Wyatt, T.R.; Yamashita, S.; Zacek, V.; Zer-Zion, D.

    2000-01-01

    A search for pair produced scalar fermions with couplings that violate R-parity has been performed using a data sample corresponding to an integrated luminosity of 56 pb-1 at a centre-of-mass energy of sqrt{s}= 183 GeV collected with the OPAL detector at LEP. An important consequence of R-parity breaking interactions is that the lightest supersymmetric particle is expected to be unstable. Searches for R-parity violating decays of charged sleptons, sneutrinos and stop quarks have been performed under the assumptions that the lightest supersymmetric particle decays promptly and that only one of the R-parity violating couplings is dominant for each of the decay modes considered. Such processes would yield multi-leptons, jets plus leptons or multi-jets, with or without missing energy, in the final state. No significant excess of such events has been observed. Limits on the production cross-sections of scalar fermions in R-parity violating scenarios are obtained. Mass exclusion regions are also presented in the fr...

  6. Development of myenteric cholinergic neurons in ChAT-Cre;R26R-YFP mice.

    Science.gov (United States)

    Hao, Marlene M; Bornstein, Joel C; Young, Heather M

    2013-10-01

    Cholinergic neurons are the major excitatory neurons of the enteric nervous system (ENS), and include intrinsic sensory neurons, interneurons, and excitatory motor neurons. Cholinergic neurons have been detected in the embryonic ENS; however, the development of these neurons has been difficult to study as they are difficult to detect prior to birth using conventional immunohistochemistry. In this study we used ChAT-Cre;R26R-YFP mice to examine the development of cholinergic neurons in the gut of embryonic and postnatal mice. Cholinergic (YFP+) neurons were first detected at embryonic day (E)11.5, and the proportion of cholinergic neurons gradually increased during pre- and postnatal development. At birth, myenteric cholinergic neurons comprised less than half of their adult proportions in the small intestine (25% of myenteric neurons were YFP+ at P0 compared to 62% in adults). The earliest cholinergic neurons appear to mainly project anally. Projections into the presumptive circular muscle were first observed at E14.5. A subpopulation of cholinergic neurons coexpress calbindin through embryonic and postnatal development, but only a small proportion coexpressed neuronal nitric oxide synthase. Our study shows that cholinergic neurons in the ENS develop over a protracted period of time. © 2013 Wiley Periodicals, Inc.

  7. Unique strategies for technical information management at Johnson Space Center

    Science.gov (United States)

    Krishen, Vijay

    1994-01-01

    In addition to the current NASA manned programs, the maturation of Space Station and the introduction of the Space Exploration programs are anticipated to add substantially to the number and variety of data and documentation at NASA Johnson Space Center (JSC). This growth in the next decade has been estimated at five to ten fold compared to the current numbers. There will be an increased requirement for the tracking and currency of space program data and documents with National pressures to realize economic benefits from the research and technological developments of space programs. From a global perspective the demand for NASA's technical data and documentation is anticipated to increase at local, national, and international levels. The primary users will be government, industry, and academia. In our present national strategy, NASA's research and technology will assume a great role in the revitalization of the economy and gaining international competitiveness. Thus, greater demand will be placed on NASA's data and documentation resources. In this paper the strategies and procedures developed by DDMS, Inc., to accommodate the present and future information utilization needs are presented. The DDMS, Inc., strategies and procedures rely on understanding user requirements, library management issues, and technological applications for acquiring, searching, storing, and retrieving specific information accurately and quickly. The proposed approach responds to changing customer requirements and product deliveries. The unique features of the proposed strategy include: (1) To establish customer driven data and documentation management through an innovative and unique methods to identify needs and requirements. (2) To implement a structured process which responds to user needs, aimed at minimizing costs and maximizing services, resulting in increased productivity. (3) To provide a process of standardization of services and procedures. This standardization is the central

  8. {Delta}r in the Two-Higgs-Doublet Model at full one loop level - and beyond

    Energy Technology Data Exchange (ETDEWEB)

    Lopez-Val, David [Universitaet Heidelberg, Institut fuer Theoretische Physik, Heidelberg (Germany); Sola, Joan [Universitat de Barcelona, Dept. Estructura i Constituents de la Materia, Barcelona, Catalonia (Spain); Institut de Ciencies del Cosmos, Barcelona, Catalonia (Spain)

    2013-04-15

    After the recent discovery of a Higgs-like boson particle at the CERN LHC-collider, it becomes more necessary than ever to prepare ourselves for identifying its standard or non-standard nature. The fundamental parameter {Delta}r, relating the values of the electroweak gauge boson masses and the Fermi constant, is the traditional observable encoding high precision information of the quantum effects. In this work we present a complete quantitative study of {Delta}r in the framework of the general Two-Higgs-Doublet Model (2HDM). While the one-loop analysis of {Delta}r in this model was carried out long ago, in the first part of our work we consistently incorporate the higher order effects that have been computed since then for the SM part of {Delta}r. Within the on-shell scheme, we find typical corrections leading to shifts of {proportional_to}20-40 MeV on the W mass, resulting in a better agreement with its experimentally measured value and in a degree no less significant than in the MSSM case. In the second part of our study we devise a set of effective couplings that capture the dominant higher order genuine 2HDM quantum effects on the {delta}{rho} part of {Delta}r in the limit of large Higgs boson self-interactions. This limit constitutes a telltale property of the general 2HDM which is unmatched by e.g. the MSSM. (orig.)

  9. Δr in the Two-Higgs-Doublet Model at full one loop level - and beyond

    International Nuclear Information System (INIS)

    Lopez-Val, David; Sola, Joan

    2013-01-01

    After the recent discovery of a Higgs-like boson particle at the CERN LHC-collider, it becomes more necessary than ever to prepare ourselves for identifying its standard or non-standard nature. The fundamental parameter Δr, relating the values of the electroweak gauge boson masses and the Fermi constant, is the traditional observable encoding high precision information of the quantum effects. In this work we present a complete quantitative study of Δr in the framework of the general Two-Higgs-Doublet Model (2HDM). While the one-loop analysis of Δr in this model was carried out long ago, in the first part of our work we consistently incorporate the higher order effects that have been computed since then for the SM part of Δr. Within the on-shell scheme, we find typical corrections leading to shifts of ∝20-40 MeV on the W mass, resulting in a better agreement with its experimentally measured value and in a degree no less significant than in the MSSM case. In the second part of our study we devise a set of effective couplings that capture the dominant higher order genuine 2HDM quantum effects on the δρ part of Δr in the limit of large Higgs boson self-interactions. This limit constitutes a telltale property of the general 2HDM which is unmatched by e.g. the MSSM. (orig.)

  10. A highly scalable information system as extendable framework solution for medical R&D projects.

    Science.gov (United States)

    Holzmüller-Laue, Silke; Göde, Bernd; Stoll, Regina; Thurow, Kerstin

    2009-01-01

    For research projects in preventive medicine a flexible information management is needed that offers a free planning and documentation of project specific examinations. The system should allow a simple, preferably automated data acquisition from several distributed sources (e.g., mobile sensors, stationary diagnostic systems, questionnaires, manual inputs) as well as an effective data management, data use and analysis. An information system fulfilling these requirements has been developed at the Center for Life Science Automation (celisca). This system combines data of multiple investigations and multiple devices and displays them on a single screen. The integration of mobile sensor systems for comfortable, location-independent capture of time-based physiological parameter and the possibility of observation of these measurements directly by this system allow new scenarios. The web-based information system presented in this paper is configurable by user interfaces. It covers medical process descriptions, operative process data visualizations, a user-friendly process data processing, modern online interfaces (data bases, web services, XML) as well as a comfortable support of extended data analysis with third-party applications.

  11. User-centered requirements engineering in health information systems: a study in the hemophilia field.

    Science.gov (United States)

    Teixeira, Leonor; Ferreira, Carlos; Santos, Beatriz Sousa

    2012-06-01

    The use of sophisticated information and communication technologies (ICTs) in the health care domain is a way to improve the quality of services. However, there are also hazards associated with the introduction of ICTs in this domain and a great number of projects have failed due to the lack of systematic consideration of human and other non-technology issues throughout the design or implementation process, particularly in the requirements engineering process. This paper presents the methodological approach followed in the design process of a web-based information system (WbIS) for managing the clinical information in hemophilia care, which integrates the values and practices of user-centered design (UCD) activities into the principles of software engineering, particularly in the phase of requirements engineering (RE). This process followed a paradigm that combines a grounded theory for data collection with an evolutionary design based on constant development and refinement of the generic domain model using three well-known methodological approaches: (a) object-oriented system analysis; (b) task analysis; and, (c) prototyping, in a triangulation work. This approach seems to be a good solution for the requirements engineering process in this particular case of the health care domain, since the inherent weaknesses of individual methods are reduced, and emergent requirements are easier to elicit. Moreover, the requirements triangulation matrix gives the opportunity to look across the results of all used methods and decide what requirements are critical for the system success. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  12. A search for R-parity violating single sneutrino production at LEPII

    International Nuclear Information System (INIS)

    Coles, J.

    2000-01-01

    Supersymmetry has become one of the most accepted and theoretically interesting extensions to the Standard Model of particle physics, yet it has so far eluded discovery. For this reason there is a large amount of interest in direct particle searches looking for evidence of either R-parity conserving or R-parity violating signatures at high-energy colliders such as LEP. This work sets out to describe one such search, that for the R-parity violating process of resonant single sneutrino production. The R-parity violating searches are performed on ALEPH data taken at centre-of-mass energies 130 to 189 GeV. As no evidence for a signal is found, limits are set within the framework of a minimal supergravity model. The best upper limits obtained for the LLE-bar couplings λ 121 and λ 131 are shown to be better than 5 x 10 -4 at 95% C.L. These results provide a substantial improvement over existing low energy bounds. (author)

  13. 76 FR 48742 - Kiwifruit Grown in California; Change in Reporting Requirements and New Information Collection

    Science.gov (United States)

    2011-08-09

    ... Reporting Requirements and New Information Collection AGENCY: Agricultural Marketing Service, USDA. ACTION... INFORMATION CONTACT: Kathie M. Notoro, Marketing Specialist, or Kurt J. Kimmel, Regional Manager, California... pertinent information, the marketing policy provides the basis for the recommendation of appropriate...

  14. Employers' Perceptions of Information Technology Competency Requirements for Management Accounting Graduates

    Science.gov (United States)

    Spraakman, Gary; O'Grady, Winifred; Askarany, Davood; Akroyd, Chris

    2015-01-01

    Management accountants work in a computerized workplace with information technology (IT) for producing financial ledgers and for reporting. Thus, the role of the management accountant has shifted from capturing and recording transactions to analyzing business issues. The research question is: what IT knowledge and skills do employers require of…

  15. 34 CFR 380.21 - What information requirement applies to this program?

    Science.gov (United States)

    2010-07-01

    ... TECHNICAL ASSISTANCE PROJECTS What Post-Award Conditions Must Be Met by a Grantee? § 380.21 What information requirement applies to this program? Each grantee must advise recipients of services under its project or, as...) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION SPECIAL PROJECTS AND...

  16. Parallel R-matrix computation

    International Nuclear Information System (INIS)

    Heggarty, J.W.

    1999-06-01

    For almost thirty years, sequential R-matrix computation has been used by atomic physics research groups, from around the world, to model collision phenomena involving the scattering of electrons or positrons with atomic or molecular targets. As considerable progress has been made in the understanding of fundamental scattering processes, new data, obtained from more complex calculations, is of current interest to experimentalists. Performing such calculations, however, places considerable demands on the computational resources to be provided by the target machine, in terms of both processor speed and memory requirement. Indeed, in some instances the computational requirements are so great that the proposed R-matrix calculations are intractable, even when utilising contemporary classic supercomputers. Historically, increases in the computational requirements of R-matrix computation were accommodated by porting the problem codes to a more powerful classic supercomputer. Although this approach has been successful in the past, it is no longer considered to be a satisfactory solution due to the limitations of current (and future) Von Neumann machines. As a consequence, there has been considerable interest in the high performance multicomputers, that have emerged over the last decade which appear to offer the computational resources required by contemporary R-matrix research. Unfortunately, developing codes for these machines is not as simple a task as it was to develop codes for successive classic supercomputers. The difficulty arises from the considerable differences in the computing models that exist between the two types of machine and results in the programming of multicomputers to be widely acknowledged as a difficult, time consuming and error-prone task. Nevertheless, unless parallel R-matrix computation is realised, important theoretical and experimental atomic physics research will continue to be hindered. This thesis describes work that was undertaken in

  17. Interactions between the R2R3-MYB transcription factor, AtMYB61, and target DNA binding sites.

    Directory of Open Access Journals (Sweden)

    Michael B Prouse

    Full Text Available Despite the prominent roles played by R2R3-MYB transcription factors in the regulation of plant gene expression, little is known about the details of how these proteins interact with their DNA targets. For example, while Arabidopsis thaliana R2R3-MYB protein AtMYB61 is known to alter transcript abundance of a specific set of target genes, little is known about the specific DNA sequences to which AtMYB61 binds. To address this gap in knowledge, DNA sequences bound by AtMYB61 were identified using cyclic amplification and selection of targets (CASTing. The DNA targets identified using this approach corresponded to AC elements, sequences enriched in adenosine and cytosine nucleotides. The preferred target sequence that bound with the greatest affinity to AtMYB61 recombinant protein was ACCTAC, the AC-I element. Mutational analyses based on the AC-I element showed that ACC nucleotides in the AC-I element served as the core recognition motif, critical for AtMYB61 binding. Molecular modelling predicted interactions between AtMYB61 amino acid residues and corresponding nucleotides in the DNA targets. The affinity between AtMYB61 and specific target DNA sequences did not correlate with AtMYB61-driven transcriptional activation with each of the target sequences. CASTing-selected motifs were found in the regulatory regions of genes previously shown to be regulated by AtMYB61. Taken together, these findings are consistent with the hypothesis that AtMYB61 regulates transcription from specific cis-acting AC elements in vivo. The results shed light on the specifics of DNA binding by an important family of plant-specific transcriptional regulators.

  18. Characterization Well R-7 Geochemistry Report

    International Nuclear Information System (INIS)

    Longmire, P.; Goff, F.

    2002-01-01

    This report provides analytical results for four groundwater-sampling rounds conducted at characterization well R-7. The goal of the characterization efforts was to assess the hydrochemistry and to determine if contaminants from Technical Area (TA)-2 and TA-21 of the Los Alamos National Laboratory (LANL or the Laboratory) are present in the regional aquifer in the vicinity of the well. Figure 1.0-1 shows the well's location in the narrow upper part of Los Alamos Canyon, between the inactive Omega West reactor and the mouth of DP Canyon. Well R-7 is in an excellent location to characterize the hydrology and groundwater chemistry in both perched groundwater and the regional aquifer near sites of known Laboratory effluent release, including radionuclides and inorganic chemicals (Stone et al. 2002, 72717). The Risk Reduction and Environmental Stewardship-Remediation (RRES-R) Program (formerly the Environmental Restoration [ER] Project) installed well R-7 as part of groundwater investigations to satisfy requirements of the ''Hydrogeologic Workplan'' (LANL 1998, 59599) and to support the Laboratory's ''Groundwater Protection Management Program Plan'' (LANL 1996, 70215). Well R-7 was designed primarily to provide geochemical or water quality and hydrogeologic data for the regional aquifer within the Puye Formation. This report also presents a geochemical evaluation of the analytical results for well R-7 and provides hydrogeochemical interpretations using analytical results for groundwater samples collected at the well. Discussion of other hydrogeochemical data collected within the east-central portion of the Laboratory, however, is deferred until they can be evaluated in the context of sitewide information collected from other RRES and Hydrogeologic Workplan characterization wells (R-8A, R-9, and R-9i). Once all deep groundwater investigations in the east-central portion of the Laboratory are completed, geochemical and hydrogeologic conceptual models for the Los Alamos

  19. 77 FR 52692 - NIST Federal Information Processing Standard (FIPS) 140-3 (Second Draft), Security Requirements...

    Science.gov (United States)

    2012-08-30

    ...-03] NIST Federal Information Processing Standard (FIPS) 140-3 (Second Draft), Security Requirements....'' Authority: Federal Information Processing Standards (FIPS) are issued by the National Institute of Standards... Standards and Technology (NIST) seeks additional comments on specific sections of Federal Information...

  20. Development Principles of the Pedagogical System Aimed at Bachelor Training Based on Modern Information Technology

    Science.gov (United States)

    Kurymbayev, Sayat G.; Samashova, Gulfarida E.; Alshynbayeva, Zhuldyz E.; Mukhametzhanova, Aigul O.; Sharazdin, Adilzada M.; Kalybekova, Kalamkas S.; Kosybaeva, Umitzhan A.

    2016-01-01

    Modern education is aimed at training competent specialists, which requires modernizing the training process by implementing innovative technologies, especially information technologies. Information technologies allow quickly accessing necessary data, which speeds up the training process. This paper deals with issues related to training bachelors…

  1. Analysis of cis and trans Requirements for DNA Replication at the Right-End Hairpin of the Human Bocavirus 1 Genome.

    Science.gov (United States)

    Shen, Weiran; Deng, Xuefeng; Zou, Wei; Engelhardt, John F; Yan, Ziying; Qiu, Jianming

    2016-09-01

    Parvoviruses are single-stranded DNA viruses that use the palindromic structures at the ends of the viral genome for their replication. The mechanism of parvovirus replication has been studied mostly in the dependoparvovirus adeno-associated virus 2 (AAV2) and the protoparvovirus minute virus of mice (MVM). Here, we used human bocavirus 1 (HBoV1) to understand the replication mechanism of bocaparvovirus. HBoV1 is pathogenic to humans, causing acute respiratory tract infections, especially in young children under 2 years old. By using the duplex replicative form of the HBoV1 genome in human embryonic kidney 293 (HEK293) cells, we identified the HBoV1 minimal replication origin at the right-end hairpin (OriR). Mutagenesis analyses confirmed the putative NS1 binding and nicking sites within the OriR. Of note, unlike the large nonstructural protein (Rep78/68 or NS1) of other parvoviruses, HBoV1 NS1 did not specifically bind OriR in vitro, indicating that other viral and cellular components or the oligomerization of NS1 is required for NS1 binding to the OriR. In vivo studies demonstrated that residues responsible for NS1 binding and nicking are within the origin-binding domain. Further analysis identified that the small nonstructural protein NP1 is required for HBoV1 DNA replication at OriR. NP1 and other viral nonstructural proteins (NS1 to NS4) colocalized within the viral DNA replication centers in both OriR-transfected cells and virus-infected cells, highlighting a direct involvement of NP1 in viral DNA replication at OriR. Overall, our study revealed the characteristics of HBoV1 DNA replication at OriR, suggesting novel characteristics of autonomous parvovirus DNA replication. Human bocavirus 1 (HBoV1) causes acute respiratory tract infections in young children. The duplex HBoV1 genome replicates in HEK293 cells and produces progeny virions that are infectious in well-differentiated airway epithelial cells. A recombinant AAV2 vector pseudotyped with an HBoV1

  2. Magnesium requirement of some of the principal rumen cellulolytic bacteria.

    Science.gov (United States)

    Morales, M S; Dehority, B A

    2014-09-01

    Information available on the role of Mg for growth and cellulose degradation by rumen bacteria is both limited and inconsistent. In this study, the Mg requirements for two strains each of the cellulolytic rumen species Fibrobacter succinogenes (A3c and S85), Ruminococcus albus (7 and 8) and Ruminococcus flavefaciens (B34b and C94) were investigated. Maximum growth, rate of growth and lag time were all measured using a complete factorial design, 2(3)×6; factors were: strains (2), within species (3) and Mg concentrations (6). R. flavefaciens was the only species that did not grow when Mg was singly deleted from the media, and both strains exhibited a linear growth response to increasing Mg concentrations (PR. flavefaciens B34b was estimated as 0.54 mM; whereas the requirement for R. flavefaciens C94 was >0.82 as there was no plateau in growth. Although not an absolute requirement for growth, strains of the two other species of cellulolytic bacteria all responded to increasing Mg concentrations. For F. succinogenes S85, R. albus 7 and R. albus 8, their requirement estimated from maximum growth was 0.56, 0.52 and 0.51, respectively. A requirement for F. succinogenes A3c could not be calculated because there was no solution for contrasts. Whether R. flavefaciens had a Mg requirement for cellulose degradation was determined in NH3-free cellulose media, using a 2×4 factorial design, 2 strains and 4 treatments. Both strains of R. flavefaciens were found to have an absolute Mg requirement for cellulose degradation. Based on reported concentrations of Mg in the rumen, 1.0 to 10.1 mM, it seems unlikely that an in vivo deficiency of this element would occur.

  3. Market Research Gathering Information About Commercial Products and Services

    National Research Council Canada - National Science Library

    1997-01-01

    DoD 5000.2-R, Mandatory Procedures for Major Defense Acquisition Programs and Major Automated Information System Acquisition Programs, requires that market research and analysis be conducted to determine...

  4. 75 FR 65700 - 60-Day Notice of Proposed Information Collection: R/PPR Evaluation and Measurement Unit...

    Science.gov (United States)

    2010-10-26

    ... Office: Office of the Under Secretary for Public Diplomacy and Public Affairs' Office of Policy, Planning... the Under Secretary for Public Diplomacy and Public Affairs, Office of Policy, Planning and Resources... DEPARTMENT OF STATE [Public Notice: 7215] 60-Day Notice of Proposed Information Collection: R/PPR...

  5. Plant rDNA database: ribosomal DNA loci information goes online

    Czech Academy of Sciences Publication Activity Database

    Garcia, S.; Garnatje, T.; Kovařík, Aleš

    2012-01-01

    Roč. 121, č. 4 (2012), s. 389-394 ISSN 0009-5915 R&D Projects: GA ČR(CZ) GAP501/10/0208; GA ČR GBP501/12/G090 Institutional research plan: CEZ:AV0Z50040702 Keywords : rDNA loci * FISH * database Subject RIV: BO - Biophysics Impact factor: 3.340, year: 2012

  6. 42 CFR 495.338 - Health information technology implementation advance planning document requirements (HIT IAPD).

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Health information technology implementation... CERTIFICATION STANDARDS FOR THE ELECTRONIC HEALTH RECORD TECHNOLOGY INCENTIVE PROGRAM Requirements Specific to the Medicaid Program § 495.338 Health information technology implementation advance planning document...

  7. Requirements for an ES and H assurance program at the working levels of organization

    International Nuclear Information System (INIS)

    Tierney, M.S.; Ellingson, A.C.

    1979-07-01

    Means by which the disciplines of quality assurance (QA), reliability (R), and human factors (HF) might be used to the advantage of Environment, Safety, and Health (ES and H) programs are being investigated. A generalized model assurance program, based on QA, R, and HF principles but specifically tailored to ES and H program needs, has been developed. Current studies address implementation of the model assurance program at the working levels of organization. It appears that the only way practicability at the working level can be determined is by the case study method. The present study represents a first step in the application of such a procedure. An attempt was made to approach the question of practicability by first constructing a generic ES and H assurance plan for working-level organizations that is based upon the more widely-applied model plan and studies mentioned earlier. Then the elements of this generic working-level plan were compared with the practices of an existing R and D organization at Sandia Laboratories, Albuquerque. Some of the necessary steps were taken to convert these practices to those required by the generic plan in order to gain a measure of the feasibility, cost, and some of the possible benefits of such a conversion. Partial results of one case study are presented, and some generalizations that emerge regarding the structure of an idealized working-level ES and H plan are made

  8. 21 CFR 1.403 - What requirements apply to an informal hearing?

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false What requirements apply to an informal hearing? 1.403 Section 1.403 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GENERAL ENFORCEMENT REGULATIONS Administrative Detention of Food for Human or Animal Consumption...

  9. Roles of PucR, G1nR, and TnrA in regulating expression of the Bacillus subtilis ure p3 promoter

    DEFF Research Database (Denmark)

    Brandenburg, J.L.; Wray, L.V.; Beier, Lars

    2002-01-01

    consensus GlnR/TnrA binding sites located in the ure P3 promoter region were shown to be required for negative regulation by GlnR. Mutational analysis indicates that a cooperative interaction occurs between GlnR dimers bound at these two sites. B. subtilis is the first example where urease expression...

  10. Disaster at a University: A Case Study in Information Security

    Science.gov (United States)

    Ayyagari, Ramakrishna; Tyks, Jonathan

    2012-01-01

    Security and disaster training is identified as a top Information Technology (IT) required skill that needs to be taught in Information Systems (IS) curriculums. Accordingly, information security and privacy have become core concepts in information system education. Providing IT security on a shoestring budget is always difficult and many small…

  11. Search for gravitinos in R-parity violating supersymmetry at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Horn, C.

    2006-07-15

    In this thesis a search for gravitinos in R{sub P}-violating supersymmetry is presented using data recorded with the ZEUS detector in the years 1996 to 2005, corresponding to an integrated luminosity of 300 pb{sup -1}. Collisions are recorded from e{sup -}p and e{sup +}p scattering at center-of-mass energies of 300 GeV and 318 GeV, using unpolarised as well as polarised lepton beams. Gravitinos are naturally expected in Gauge Mediated Supersymmetry Breaking (GMSB) models where the gravitino is the lightest supersymmetric particle. At HERA gravitinos may result from the GMSB decay of neutralinos ({chi}{sup 0}{yields}{gamma}G) produced in t-channel slepton exchange processes (eq{yields}q'{chi}) via an R{sub P}-violating (R{sub P}) Yukawa coupling {lambda}'{sub ijk}. It was assumed that only one of the R{sub P} couplings {lambda}'{sub 111}, {lambda}'{sub 121}, {lambda}'{sub 112} or {lambda}'{sub 113} is different from zero at a time. To extend the investigated GMSB parameter space, also the two dominant R{sub P}-violating decay channels ({chi}{yields}e{sup {+-}}qq and {chi}{yields}{nu}qq) were taken into account. For the signal-to-background optimisation a dynamic discriminant method was developed. The data was observed to be well described by the expected Standard Model processes and no evidence for the production of supersymmetric particles was found. Limits were calculated for the masses of the left-handed selectron and the lightest neutralino and the variation of these limits was investigated in the entire GMSB parameter space. For some parameter regions, selectron masses of up to 360 GeV and neutralino masses of up to 190 GeV can be excluded at 95% CL. Similar mass limits were found to hold for large regions of GMSB parameter space. (orig.)

  12. Search for gravitinos in R-parity violating supersymmetry at HERA

    International Nuclear Information System (INIS)

    Horn, C.

    2006-07-01

    In this thesis a search for gravitinos in R P -violating supersymmetry is presented using data recorded with the ZEUS detector in the years 1996 to 2005, corresponding to an integrated luminosity of 300 pb -1 . Collisions are recorded from e - p and e + p scattering at center-of-mass energies of 300 GeV and 318 GeV, using unpolarised as well as polarised lepton beams. Gravitinos are naturally expected in Gauge Mediated Supersymmetry Breaking (GMSB) models where the gravitino is the lightest supersymmetric particle. At HERA gravitinos may result from the GMSB decay of neutralinos (χ 0 →γG) produced in t-channel slepton exchange processes (eq→q'χ) via an R P -violating (R P ) Yukawa coupling λ' ijk . It was assumed that only one of the R P couplings λ' 111 , λ' 121 , λ' 112 or λ' 113 is different from zero at a time. To extend the investigated GMSB parameter space, also the two dominant R P -violating decay channels (χ→e ± qq and χ→νqq) were taken into account. For the signal-to-background optimisation a dynamic discriminant method was developed. The data was observed to be well described by the expected Standard Model processes and no evidence for the production of supersymmetric particles was found. Limits were calculated for the masses of the left-handed selectron and the lightest neutralino and the variation of these limits was investigated in the entire GMSB parameter space. For some parameter regions, selectron masses of up to 360 GeV and neutralino masses of up to 190 GeV can be excluded at 95% CL. Similar mass limits were found to hold for large regions of GMSB parameter space. (orig.)

  13. RJSplot: Interactive Graphs with R.

    Science.gov (United States)

    Barrios, David; Prieto, Carlos

    2018-03-01

    Data visualization techniques provide new methods for the generation of interactive graphs. These graphs allow a better exploration and interpretation of data but their creation requires advanced knowledge of graphical libraries. Recent packages have enabled the integration of interactive graphs in R. However, R provides limited graphical packages that allow the generation of interactive graphs for computational biology applications. The present project has joined the analytical power of R with the interactive graphical features of JavaScript in a new R package (RJSplot). It enables the easy generation of interactive graphs in R, provides new visualization capabilities, and contributes to the advance of computational biology analytical methods. At present, 16 interactive graphics are available in RJSplot, such as the genome viewer, Manhattan plots, 3D plots, heatmaps, dendrograms, networks, and so on. The RJSplot package is freely available online at http://rjsplot.net. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. 76 FR 44306 - Proposed Information Collection; Comment Request; Fisheries Finance Program Requirements

    Science.gov (United States)

    2011-07-25

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration Proposed Information Collection; Comment Request; Fisheries Finance Program Requirements AGENCY: National Oceanic and Atmospheric Administration (NOAA), Commerce. ACTION: Notice. SUMMARY: The Department of Commerce, as part of its continuing...

  15. Proposals for the 1989/90 Safeguards R and D programme and associated meetings

    International Nuclear Information System (INIS)

    1987-07-01

    The R and D programme of the IAEA Department of Safeguards as carried out by or undertaken on behalf of the Division of Development and Technical Support, the Division of Safeguards Evaluation and the Division of Safeguards Information Treatment is set out in tables which give the objective of the programme elements, a description of the activities to be performed and a number of items of information required for assessment of the activities. The linkage between R and D activities and planned meetings on safeguards topics in 1989/90 is shown in a table too. 4 tabs

  16. An improved slow neutron spectrometer at nuclear research reactor et-r r-1. Vol. 2

    Energy Technology Data Exchange (ETDEWEB)

    Abu El-Ela, M A [Reactor and Neutron Physics, Nuclear Research Center, AEA, Cairo (Egypt)

    1996-03-01

    An improved slow neutron selector has been aligned at channel number 6 of the nuclear research reactor ET-R R-1 Inshas. The flight path is 4 meter. The collimator-rotor-collimator system has the dimensions 0.3 x 2.5 x 70 cm with the rotor diameter 16 cm and 3 slits of 0.3 x 2.5 cm cross section. The rotor rotation rate varies between 600 r.p.m. the counting system has one of the best modern high electronic advanced technology time analyzer with minimum dwell time 2 sec, 8192 channels and a double detector inputs of TTL and NEG NIM standard pulses. The analyzer external triggering signals are of TTL standard type. A special design {sup 3} He detector for time of flight spectrometry has been used in the SNS. The reactor bare thermal neutron spectrum has been successfully measured, to show good agreement with the previous data. 6 figs.

  17. $R_{b}$ measurements at centre-of-mass energy above the Z pole at LEP

    CERN Document Server

    Ruggiero, G

    2001-01-01

    The measurements of R/sub b/= sigma (e/sup +/e/sup -/ to bb)/ sigma (e/sup +/e/sup -/ to qq) at centre-of-mass energies above the Z pole using data collected by the LEP experiments from 1995 to 1999 are summarised. The measurements are performed using b-tagging methods that exploit the relatively large decay length of b hadrons. A preliminary combination of the R/sub b/ measurements is also presented. (9 refs).

  18. Depression-Biased Reverse Plasticity Rule Is Required for Stable Learning at Top-Down Connections

    Science.gov (United States)

    Burbank, Kendra S.; Kreiman, Gabriel

    2012-01-01

    Top-down synapses are ubiquitous throughout neocortex and play a central role in cognition, yet little is known about their development and specificity. During sensory experience, lower neocortical areas are activated before higher ones, causing top-down synapses to experience a preponderance of post-synaptic activity preceding pre-synaptic activity. This timing pattern is the opposite of that experienced by bottom-up synapses, which suggests that different versions of spike-timing dependent synaptic plasticity (STDP) rules may be required at top-down synapses. We consider a two-layer neural network model and investigate which STDP rules can lead to a distribution of top-down synaptic weights that is stable, diverse and avoids strong loops. We introduce a temporally reversed rule (rSTDP) where top-down synapses are potentiated if post-synaptic activity precedes pre-synaptic activity. Combining analytical work and integrate-and-fire simulations, we show that only depression-biased rSTDP (and not classical STDP) produces stable and diverse top-down weights. The conclusions did not change upon addition of homeostatic mechanisms, multiplicative STDP rules or weak external input to the top neurons. Our prediction for rSTDP at top-down synapses, which are distally located, is supported by recent neurophysiological evidence showing the existence of temporally reversed STDP in synapses that are distal to the post-synaptic cell body. PMID:22396630

  19. Depression-biased reverse plasticity rule is required for stable learning at top-down connections.

    Directory of Open Access Journals (Sweden)

    Kendra S Burbank

    Full Text Available Top-down synapses are ubiquitous throughout neocortex and play a central role in cognition, yet little is known about their development and specificity. During sensory experience, lower neocortical areas are activated before higher ones, causing top-down synapses to experience a preponderance of post-synaptic activity preceding pre-synaptic activity. This timing pattern is the opposite of that experienced by bottom-up synapses, which suggests that different versions of spike-timing dependent synaptic plasticity (STDP rules may be required at top-down synapses. We consider a two-layer neural network model and investigate which STDP rules can lead to a distribution of top-down synaptic weights that is stable, diverse and avoids strong loops. We introduce a temporally reversed rule (rSTDP where top-down synapses are potentiated if post-synaptic activity precedes pre-synaptic activity. Combining analytical work and integrate-and-fire simulations, we show that only depression-biased rSTDP (and not classical STDP produces stable and diverse top-down weights. The conclusions did not change upon addition of homeostatic mechanisms, multiplicative STDP rules or weak external input to the top neurons. Our prediction for rSTDP at top-down synapses, which are distally located, is supported by recent neurophysiological evidence showing the existence of temporally reversed STDP in synapses that are distal to the post-synaptic cell body.

  20. 21 CFR 207.25 - Information required in registration and drug listing.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Information required in registration and drug listing. 207.25 Section 207.25 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... manufactured by a registered blood bank, a copy of all current labeling (except that only one representative...

  1. An object model for genome information at all levels of resolution

    Energy Technology Data Exchange (ETDEWEB)

    Honda, S.; Parrott, N.W.; Smith, R.; Lawrence, C.

    1993-12-31

    An object model for genome data at all levels of resolution is described. The model was derived by considering the requirements for representing genome related objects in three application domains: genome maps, large-scale DNA sequencing, and exploring functional information in gene and protein sequences. The methodology used for the object-oriented analysis is also described.

  2. Development of technical information processing system (VII)

    International Nuclear Information System (INIS)

    Kim, Tae Whan; Choi, Kwang; Oh, Jeong Hoon; Jeong, Hyun Sook; Keum, Jong Yong

    1995-12-01

    The goal of this project is to establish integrated environment focused on enhanced information services to researchers through the providing of acquisition information, key phrase retrieval function, journal content information linked with various subsystems already developed. The results of the project are as follows. 1. It is possible to serve information on unreceivable materials among required materials throughout the system. 2. Retrieval efficiency is increased by the adding of key phrase retrieval function. 3. Rapidity of information service is enhanced by the providing of journal contents of each issue received and work performance of contents service is become higher. 4. It is possible to acquire, store, serve technical information needed in R and D synthetically and systematically throughout the development of total system linked with various subsystems required to technical information management and service. 21 refs. (Author)

  3. 75 FR 80066 - Quality Control Requirements for Direct Endorsement Lenders; Notice of Proposed Information...

    Science.gov (United States)

    2010-12-21

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5380-N-50] Quality Control Requirements... information: Title of Proposal: Quality Control Requirements for Direct Endorsement Lenders. OMB Control... a result, DE lenders will be responsible for conducting quality control on TPO originations of FHA...

  4. Angiotensin II reduces cardiac AdipoR1 expression through AT1 receptor/ROS/ERK1/2/c-Myc pathway.

    Directory of Open Access Journals (Sweden)

    Li Li

    Full Text Available Adiponectin, an abundant adipose tissue-derived protein, exerts protective effect against cardiovascular disease. Adiponectin receptors (AdipoR1 and AdipoR2 mediate the beneficial effects of adiponectin on the cardiovascular system. However, the alteration of AdipoRs in cardiac remodeling is not fully elucidated. Here, we investigated the effect of angiotensin II (AngII on cardiac AdipoRs expression and explored the possible molecular mechanism. AngII infusion into rats induced cardiac hypertrophy, reduced AdipoR1 but not AdipoR2 expression, and attenuated the phosphorylations of adenosine monophosphate-activated protein kinase and acetyl coenzyme A carboxylase, and those effects were all reversed by losartan, an AngII type 1 (AT1 receptor blocker. AngII reduced expression of AdipoR1 mRNA and protein in cultured neonatal rat cardiomyocytes, which was abolished by losartan, but not by PD123319, an AT2 receptor antagonist. The antioxidants including reactive oxygen species (ROS scavenger NAC, NADPH oxidase inhibitor apocynin, Nox2 inhibitor peptide gp91 ds-tat, and mitochondrial electron transport chain complex I inhibitor rotenone attenuated AngII-induced production of ROS and phosphorylation of extracellular signal-regulated kinase (ERK 1/2. AngII-reduced AdipoR1 expression was reversed by pretreatment with NAC, apocynin, gp91 ds-tat, rotenone, and an ERK1/2 inhibitor PD98059. Chromatin immunoprecipitation assay demonstrated that AngII provoked the recruitment of c-Myc onto the promoter region of AdipoR1, which was attenuated by PD98059. Moreover, AngII-induced DNA binding activity of c-Myc was inhibited by losartan, NAC, apocynin, gp91 ds-tat, rotenone, and PD98059. c-Myc small interfering RNA abolished the inhibitory effect of AngII on AdipoR1 expression. Our results suggest that AngII inhibits cardiac AdipoR1 expression in vivo and in vitro and AT1 receptor/ROS/ERK1/2/c-Myc pathway is required for the downregulation of AdipoR1 induced by AngII.

  5. Information system design and its implementation at the SNSA

    International Nuclear Information System (INIS)

    Rasula, J.; Stritar, A.; Osojnik, I.; Pungercar, D.

    2005-01-01

    In 2003, the Slovenian Nuclear Safety Administration (SNSA) decided to launch a Preliminary Investigation and Requirements Analysis study for a new information system (IS). A decision was made to start developing the information system from scratch, without fully realising its future potential. Finally, in 2004, the information system portal named InfoURSJV was fully developed. The development of the system began by setting up two registers, based on legislation. The Ionising Radiation Protection and Nuclear Safety Act defines registers containing information on radiation sources and radiation practices. In accordance with this Act, the register of radiation practices and the register of radiation sources shall be maintained as public registers by the ministry competent for the environment. Both registers were developed as modules in InfoURSJV at the end of 2004 and are used on a daily basis. The main objective of the register of radiation practices was to create a powerful tool that allows users to view, filter, search, sort, browse and analyse all persons who carry out a radiation practice. Gradually, we have set new objectives for the information system. One of our main objectives is to use the data and information with the intention to become a customerfriendly administration, where the importance of suitable information support must be emphasised. We have set up registers to determine which persons are carrying out radiation practices without a valid licence and which licences will soon expire. Now, we are able to remind our customers that they should apply for a new permit before it runs out. The objective of this paper is to demonstrate how our information system could be used on our way to becoming a customer-friendly administration. Furthermore, it should be emphasised that we are developing a quality management system that is evolving into a tool for every sector and department at the SNSA, from licensing to inspection. (author)

  6. W. R. Grace: Plant Uses Six Sigma Methodology and Traditional Heat Balance Analysis to Identify Energy Conservation Opportunities at Curtis Bay Works (Revised)

    Energy Technology Data Exchange (ETDEWEB)

    2003-12-01

    The plant-wide energy assessment at W. R. Grace's Curtis Bay Works helped identify four projects with combined potential savings of $840,000 per year. A separate, unique project that would partner W. R. Grace with the City of Baltimore to recover and use landfill gas (methane) to cogenerate steam and electricity was also identified during the assessment. If implemented, the project would recover gas from the landfill to replace 40% of the electricity and 65% of the fuel currently required to produce steam at Curtis Bay Works. Annual savings are estimated at $900,000 to $1.2 million.

  7. MODELING OF TECHNICAL CHANNELS OF INFORMATION LEAKAGE AT DISTRIBUTED CONTROL OBJECTS

    Directory of Open Access Journals (Sweden)

    Aleksander Vladimirovich Karpov

    2018-05-01

    Full Text Available The significant increase in requirements for distributed control objects’ functioning can’t be realized only at the expense of the widening and strengthening of security control measures. The first step in ensuring the information security at such objects is the analysis of the conditions of their functioning and modeling of technical channels of information leakage. The development of models of such channels is essentially the only method of complete study of their opportunities and it is pointed toward receiving quantitative assessments of the safe operation of compound objects. The evaluation data are necessary to make a decision on the degree of the information security from a leak according to the current criterion. The existing models are developed for the standard concentrated objects and allow to evaluate the level of information security from a leak on each of channels separately, what involves the significant increase in the required protective resource and time of assessment of information security on an object in general. The article deals with a logical-and-probabilistic method of a security assessment of structurally-compound objects. The model of a security leak on the distributed control objects is cited as an example. It is recommended to use a software package of an automated structurally-logistical modeling of compound systems, which allows to evaluate risk of information leakage in the loudspeaker. A possibility of information leakage by technical channels is evaluated and such differential characteristics of the safe operation of the distributed control objects as positive and negative contributions of the initiating events and conditions, which cause a leak are calculated. Purpose. The aim is a quantitative assessment of data risk, which is necessary for justifying the rational composition of organizational and technical protection measures, as well as a variant of the structure of the information security system from a

  8. Kinetic properties of 'dual' orexin receptor antagonists at OX1R and OX2R orexin receptors.

    Directory of Open Access Journals (Sweden)

    Gabrielle Elizabeth Callander

    2013-12-01

    Full Text Available Orexin receptor antagonists represent attractive targets for the development of drugs for the treatment of insomnia. Both efficacy and safety are crucial in clinical settings and thorough investigations of pharmacokinetics and pharmacodynamics can predict contributing factors such as duration of action and undesirable effects. To this end, we studied the interactions between various ‘dual’ orexin receptor antagonists and the orexin receptors, OX1R and OX2R, over time using saturation and competition radioligand binding with [3H]-BBAC ((S-N-([1,1'-biphenyl]-2-yl-1-(2-((1-methyl-1H-benzo[d]imidazol-2-ylthioacetylpyrrolidine-2-carboxamide. In addition, the kinetics of these compounds were investigated in cells expressing human, mouse and rat OX1R and OX2R using FLIPR® assays for calcium accumulation. We demonstrate that almorexant reaches equilibrium very slowly at OX2R, whereas SB-649868, suvorexant and filorexant may take hours to reach steady state at both orexin receptors. By contrast, compounds such as BBAC or the selective OX2R antagonist IPSU ((2-((1H-Indol-3-ylmethyl-9-(4-methoxypyrimidin-2-yl-2,9-diazaspiro[5.5]undecan-1-one bind rapidly and reach equilibrium very quickly in both binding and / or functional assays. Overall, the dual antagonists tested here tend to be rather unselective under non-equilibrium conditions and reach equilibrium very slowly. Once equilibrium is reached, each ligand demonstrates a selectivity profile that is however, distinct from the non-equilibrium condition. The slow kinetics of the dual antagonists tested suggest that in vitro receptor occupancy may be longer lasting than would be predicted. This raises questions as to whether pharmacokinetic studies measuring plasma or brain levels of these antagonists are accurate reflections of receptor occupancy in vivo.

  9. Environmental, Health and Safety Assessment: ATS 7H Program (Phase 3R) Test Activities at the GE Power Systems Gas Turbine Manufacturing Facility, Greenville, SC

    Energy Technology Data Exchange (ETDEWEB)

    None

    1998-11-17

    International Technology Corporation (IT) was contracted by General Electric Company (GE) to assist in the preparation of an Environmental, Health and Safety (HI&3) assessment of the implementation of Phase 3R of the Advanced Turbine System (ATS) 7H program at the GE Gas Turbines facility located in Greenville, South Carolina. The assessment was prepared in accordance with GE's contractual agreement with the U.S. Department of Energy (GE/DOE Cooperative Agreement DE-FC21-95MC3 1176) and supports compliance with the requirements of the National Environmental Policy Act of 1970. This report provides a summary of the EH&S review and includes the following: General description of current site operations and EH&S status, Description of proposed ATS 7H-related activities and discussion of the resulting environmental, health, safety and other impacts to the site and surrounding area. Listing of permits and/or licenses required to comply with federal, state and local regulations for proposed 7H-related activities. Assessment of adequacy of current and required permits, licenses, programs and/or plans.

  10. Evaluation of Adobe[R] Presenter as a Teaching Tool

    Science.gov (United States)

    Grabowski, Michelle

    2010-01-01

    Adobe[R] Presenter software provides educators with a tool to create narrated distance learning presentations. This article describes Adobe[R] Presenter's many features and explains which most strongly affect learning. Six Adobe[R] Presenter trainings were presented to 62 volunteers preparing to provide information at a public outreach event. One…

  11. Das Framework for Information Literacy. Neue Impulse für die Förderung von Informationskompetenz in Deutschland?!

    Directory of Open Access Journals (Sweden)

    Fabian Franke

    2017-12-01

    Full Text Available Das Framework for Information Literacy for Higher Education wurde im Januar 2016 vom Vorstand der Association of College & Research Libraries (ACRL beschlossen. Es beruht auf der Idee von „Threshold Concepts“ und sieht Informationskompetenz in einem engen Zusammenhang mit Wissenschaft und Forschung. Dadurch legt es bei der Vermittlung von Informationskompetenz eine starke Betonung auf das „Warum“, nicht nur auf das „Was“. Der Ansatz des Framework wird vielfach kontrovers diskutiert. Bietet er tatsächlich eine neue Sichtweise auf die Förderung von Informationskompetenz oder ist er überwiegend alter Wein in neuen Schläuchen? Kann das Framework neue Impulse für die Aktivitäten an den Bibliotheken in Deutschland setzen oder beschreibt es etwas, was wir längst machen? Der Beitrag versucht, Anregungen zu geben, welche Konsequenzen das Framework für unsere Kurse haben kann und welche veränderten Lernziele mit ihm verbunden sein können. Dabei plädiert er für ein umfassendes Verständnis von Informationskompetenz, das sich nicht auf Einzelaspekte wie Recherchekompetenz beschränkt. The Framework for Information Literacy for Higher Education was adopted by the Board of the Association of College & Research Libraries (ACRL in January 2017. It is based on the idea of threshold concepts and connects information literacy, research and scholarship. Therefore it focuses primarily on the “Why”, not only on the “What”. The approach of the Framework has often been controversially discussed. Does it actually provide a new perspective on the promotion of information literacy? Can the Framework provide new impetus for the activities of the German libraries, or does it describe something we are already doing? The paper tries to give suggestions how the framework may help to improve our courses. The author argues for a comprehensive understanding of information literacy, which is not limited to individual aspects such as research

  12. The gputools package enables GPU computing in R.

    Science.gov (United States)

    Buckner, Joshua; Wilson, Justin; Seligman, Mark; Athey, Brian; Watson, Stanley; Meng, Fan

    2010-01-01

    By default, the R statistical environment does not make use of parallelism. Researchers may resort to expensive solutions such as cluster hardware for large analysis tasks. Graphics processing units (GPUs) provide an inexpensive and computationally powerful alternative. Using R and the CUDA toolkit from Nvidia, we have implemented several functions commonly used in microarray gene expression analysis for GPU-equipped computers. R users can take advantage of the better performance provided by an Nvidia GPU. The package is available from CRAN, the R project's repository of packages, at http://cran.r-project.org/web/packages/gputools More information about our gputools R package is available at http://brainarray.mbni.med.umich.edu/brainarray/Rgpgpu

  13. Endoplasmic reticulum stress increases AT1R mRNA expression via TIA-1-dependent mechanism.

    Science.gov (United States)

    Backlund, Michael; Paukku, Kirsi; Kontula, Kimmo K; Lehtonen, Jukka Y A

    2016-04-20

    As the formation of ribonucleoprotein complexes is a major mechanism of angiotensin II type 1 receptor (AT1R) regulation, we sought to identify novel AT1R mRNA binding proteins. By affinity purification and mass spectroscopy, we identified TIA-1. This interaction was confirmed by colocalization of AT1R mRNA and TIA-1 by FISH and immunofluorescence microscopy. In immunoprecipitates of endogenous TIA- 1, reverse transcription-PCR amplified AT1R mRNA. TIA-1 has two binding sites within AT1R 3'-UTR. The binding site proximal to the coding region is glyceraldehyde-3-phosphate dehydrogenase (GAPDH)-dependent whereas the distal binding site is not. TIA-1 functions as a part of endoplasmic reticulum (ER) stress response leading to stress granule (SG) formation and translational silencing. We and others have shown that AT1R expression is increased by ER stress-inducing factors. In unstressed cells, TIA-1 binds to AT1R mRNA and decreases AT1R protein expression. Fluorescence microscopy shows that ER stress induced by thapsigargin leads to the transfer of TIA-1 to SGs. In FISH analysis AT1R mRNA remains in the cytoplasm and no longer colocalizes with TIA-1. Thus, release of TIA-1-mediated suppression by ER stress increases AT1R protein expression. In conclusion, AT1R mRNA is regulated by TIA-1 in a ER stress-dependent manner. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

  14. Negotiation of Meaning in Required and Optional Information Exchange Tasks: Discourse Issues

    Directory of Open Access Journals (Sweden)

    Zohre Mohamadi

    2015-01-01

    Full Text Available It is widely argued that different types of tasks facilitate the acquisition of communicative language to different degrees through providing different contexts for the occurrence of negotiation of meaning which is believed to have facilitative role in language acquisition. Although task based instruction provides a medium for acquiring the communicative language, it suffers from a number of oversimplifications.  The potentials of each task type in creating such a medium were not investigated in exhaustive detail, and it is left as a potentially interesting topic for further research.  This paper reports the analysis of the negotiation of meaning produced by eight intermediate EFL students engaged in required and optional information exchange tasks in dyads.  The results show that pushed output has different quality in these different task types meaning whereas required information exchange task provided a medium for more incidence of negotiation work, optional information exchange tasks engaged participants more with discourse work and led to more incidence of the clarification request as an interactional move that has a facilitative role in pushed output. Test constructors and materials developers need to take principled decisions in what to be included in the tests and texts.

  15. Data Processing Languages for Business Intelligence. SQL vs. R

    Directory of Open Access Journals (Sweden)

    Marin FOTACHE

    2016-01-01

    Full Text Available As data centric approach, Business Intelligence (BI deals with the storage, integration, processing, exploration and analysis of information gathered from multiple sources in various formats and volumes. BI systems are generally synonymous to costly, complex platforms that require vast organizational resources. But there is also an-other face of BI, that of a pool of data sources, applications, services developed at different times using different technologies. This is “democratic” BI or, in some cases, “fragmented”, “patched” (or “chaotic” BI. Fragmentation creates not only integration problems, but also supports BI agility as new modules can be quickly developed. Among various languages and tools that cover large extents of BI activities, SQL and R are instrumental for both BI platform developers and BI users. SQL and R address both monolithic and democratic BI. This paper compares essential data processing features of two languages, identifying similarities and differences among them and also their strengths and limits.

  16. Information Operations - Analysis Support and Capability Requirements (Operations d'information - Soutien a l'analyse et exigences de capacites) (CD-ROM)

    National Research Council Canada - National Science Library

    2006-01-01

    ...: The focus of the study "Information Operations - Analysis Support and Capability Requirements" undertaken by the RTO Task Group SAS-057 was to provide recommendations to improve analysis support...

  17. Models of Human Information Requirements: "When Reasonable Aiding Systems Disagree"

    Science.gov (United States)

    Corker, Kevin; Pisanich, Gregory; Shafto, Michael (Technical Monitor)

    1994-01-01

    Aircraft flight management and Air Traffic Control (ATC) automation are under development to maximize the economy of flight and to increase the capacity of the terminal area airspace while maintaining levels of flight safety equal to or better than current system performance. These goals are being realized by the introduction of flight management automation aiding and operations support systems on the flight deck and by new developments of ATC aiding systems that seek to optimize scheduling of aircraft while potentially reducing required separation and accounting for weather and wake vortex turbulence. Aiding systems on both the flight deck and the ground operate through algorithmic functions on models of the aircraft and of the airspace. These models may differ from each other as a result of variations in their models of the immediate environment. The resultant flight operations or ATC commands may differ in their response requirements (e.g. different preferred descent speeds or descent initiation points). The human operators in the system must then interact with the automation to reconcile differences and resolve conflicts. We have developed a model of human performance including cognitive functions (decision-making, rule-based reasoning, procedural interruption recovery and forgetting) that supports analysis of the information requirements for resolution of flight aiding and ATC conflicts. The model represents multiple individuals in the flight crew and in ATC. The model is supported in simulation on a Silicon Graphics' workstation using Allegro Lisp. Design guidelines for aviation automation aiding systems have been developed using the model's specification of information and team procedural requirements. Empirical data on flight deck operations from full-mission flight simulation are provided to support the model's predictions. The paper describes the model, its development and implementation, the simulation test of the model predictions, and the empirical

  18. Transition of R&D into Operations at Fleet Numerical Meteorology and Oceanography Center

    Science.gov (United States)

    Clancy, R. M.

    2006-12-01

    The U.S. Navy's Fleet Numerical Meteorology and Oceanography Center (FNMOC) plays a significant role in the National capability for operational weather and ocean prediction through its operation of sophisticated global and regional meteorological and oceanographic models, extending from the top of the atmosphere to the bottom of the ocean. FNMOC uniquely satisfies the military's requirement for a global operational weather prediction capability based on software certified to DoD Information Assurance standards and operated in a secure classified computer environment protected from outside intrusion by DoD certified firewalls. FNMOC operates around-the-clock, 365 days per year and distributes products to military and civilian users around the world, both ashore and afloat, through a variety of means. FNMOC's customers include all branches of the Department of Defense, other government organizations such as the National Weather Service, private companies, a number of colleges and universities, and the general public. FNMOC employs three primary models, the Navy Operational Global Atmospheric Prediction System (NOGAPS), the Coupled Ocean/Atmosphere Mesoscale Prediction System (COAMPS), and the WaveWatch III model (WW3), along with a number of specialized models and related applications. NOGAPS is a global weather model, driving nearly all other FNMOC models and applications in some fashion. COAMPS is a high- resolution regional model that has proved to be particularly valuable for forecasting weather and ocean conditions in highly complex coastal areas. WW3 is a state-of-the-art ocean wave model that is employed both globally and regionally in support of a wide variety of naval operations. Other models support and supplement the main models with predictions of ocean thermal structure, ocean currents, sea-ice characteristics, and other data. Fleet Numerical operates at the leading edge of science and technology, and benefits greatly from collocation with its supporting

  19. 78 FR 56898 - Emergency Clearance: Public Information Collection Requirements Submitted to the Office of...

    Science.gov (United States)

    2013-09-16

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Medicare and Medicaid Services [Document Identifier: CMS-10371] Emergency Clearance: Public Information Collection Requirements Submitted to the Office of Management and Budget (OMB) AGENCY: Center for Medicare and Medicaid Services, HHS. In compliance with the requirement of section 3506(c)(2)...

  20. Current products and future plan of regulatory technology R and D for risk-informed regulation and applications

    International Nuclear Information System (INIS)

    Song, K. Y.; Lee, C. J.; Kim, W. S.; Jeong, D. W.; Kim, H. J.

    2002-01-01

    The first phase of a R and D project for risk-informed regulation (RIR) and applications (RIA) has been finished. Various results which would be useful for preparing domestic RIR system were accomplished, in areas of safety goals and general principles of RIR, which provide fundamental bases for establishment of RIR system as well as regulatory review guides, which ensure the quality for PSA. RIA guidelines for ISI, IST, MOV, Tech.-Sepc. also have been developed, implementing some pilot plant applications. As essential documents for actual RIR inspection, risk-informed inspection guides and implementation guide for maintenance effectiveness were prepared. In the second phase of R and D, two projects on RIR area will be performed. One is to study on institutionalization of RIR and performance-based regulation, another is to develop a PSA model for regulatory audit as well as regulatory technology for risk monitoring

  1. The Important of the Usage of Information Technology during the Local Services: Special Provincial Administration of Kırşehir

    Directory of Open Access Journals (Sweden)

    Mustafa KOCAOĞLU

    2014-06-01

    Full Text Available The development of information and communication technologies has accelerated public service delivery through the application of information technologies in the world. In addition to these improvements, as a consequence of the reform efforts in the 2000s, important changes have occurred in the quality and quantity of the duties of local governments. It is expressed that the usage of information technologies for public service provision is making important contribution to local governments to fulfill their duties and responsibilities. In this paper aims the analyze that the usage of information technology during the local services delivery at The Special Provincial Administration of Kırşehir. Survey and interview were used as a method of the field research and additionally, the web site of the institute was analyzed. The results of the survey revealed that it has made progress in the efforts of computerization and web site development. The institute is expected to show progress on online service delivery and online management.

  2. 40 CFR 270.24 - Specific part B information requirements for process vents.

    Science.gov (United States)

    2010-07-01

    ... incinerator, flare, boiler, process heater, condenser, or carbon adsorption system to comply with the... each compliance test required by § 264.1033(k). (3) A design analysis, specifications, drawings... texts acceptable to the Regional Administrator that present basic control device information. The design...

  3. 78 FR 16299 - Proposed Extension of the Approval of Information Collection Requirements

    Science.gov (United States)

    2013-03-14

    ... Federal minimum wage, overtime pay, recordkeeping, and youth employment standards of most general... DEPARTMENT OF LABOR Wage and Hour Division RIN 1235-0018 Proposed Extension of the Approval of Information Collection Requirements AGENCY: Wage and Hour Division, Department of Labor. ACTION: Notice...

  4. VHA mental health information system: applying health information technology to monitor and facilitate implementation of VHA Uniform Mental Health Services Handbook requirements.

    Science.gov (United States)

    Trafton, Jodie A; Greenberg, Greg; Harris, Alex H S; Tavakoli, Sara; Kearney, Lisa; McCarthy, John; Blow, Fredric; Hoff, Rani; Schohn, Mary

    2013-03-01

    To describe the design and deployment of health information technology to support implementation of mental health services policy requirements in the Veterans Health Administration (VHA). Using administrative and self-report survey data, we developed and fielded metrics regarding implementation of the requirements delineated in the VHA Uniform Mental Health Services Handbook. Finalized metrics were incorporated into 2 external facilitation-based quality improvement programs led by the VHA Mental Health Operations. To support these programs, tailored site-specific reports were generated. Metric development required close collaboration between program evaluators, policy makers and clinical leadership, and consideration of policy language and intent. Electronic reports supporting different purposes required distinct formatting and presentation features, despite their having similar general goals and using the same metrics. Health information technology can facilitate mental health policy implementation but must be integrated into a process of consensus building and close collaboration with policy makers, evaluators, and practitioners.

  5. Recognition of AT-Rich DNA Binding Sites by the MogR Repressor

    Energy Technology Data Exchange (ETDEWEB)

    Shen, Aimee; Higgins, Darren E.; Panne, Daniel; (Harvard-Med); (EMBL)

    2009-07-22

    The MogR transcriptional repressor of the intracellular pathogen Listeria monocytogenes recognizes AT-rich binding sites in promoters of flagellar genes to downregulate flagellar gene expression during infection. We describe here the 1.8 A resolution crystal structure of MogR bound to the recognition sequence 5' ATTTTTTAAAAAAAT 3' present within the flaA promoter region. Our structure shows that MogR binds as a dimer. Each half-site is recognized in the major groove by a helix-turn-helix motif and in the minor groove by a loop from the symmetry-related molecule, resulting in a 'crossover' binding mode. This oversampling through minor groove interactions is important for specificity. The MogR binding site has structural features of A-tract DNA and is bent by approximately 52 degrees away from the dimer. The structure explains how MogR achieves binding specificity in the AT-rich genome of L. monocytogenes and explains the evolutionary conservation of A-tract sequence elements within promoter regions of MogR-regulated flagellar genes.

  6. Information Requirements and Consumer Protection in Future M-Commerce

    DEFF Research Database (Denmark)

    Cleff, Evelyne Beatrix; Henschel, Rene Franz

    2007-01-01

      The aim of this article is to discuss information requirements and consumer protection in mobile commerce. On the basis of a brief introduction to the characteristics of mobile commerce and the regulatory framework that governs mobile commerce in the European Union today, the article presents...... that the solution may be relaxed enforcement of the regulatory framework and/or self-regulation, e.g. by codes of conduct. However, the article argues that other possible solutions should be considered, e.g. the use of specific symbols and sounds that - like road traffic rules - could help the consumer to navigate...

  7. 78 FR 51729 - Emergency Clearance: Public Information Collection Requirements Submitted to the Office of...

    Science.gov (United States)

    2013-08-21

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Medicare and Medicaid Services [Document Identifier: CMS-10496 Emergency Clearance: Public Information Collection Requirements Submitted to the Office of Management and Budget (OMB) AGENCY: Center for Medicare and Medicaid Services. In compliance with the requirement of section 3506(c)(2)(A) of...

  8. 26 CFR 54.9802-3T - Additional requirements prohibiting discrimination based on genetic information (temporary).

    Science.gov (United States)

    2010-04-01

    ... assembles the data requested by M and, although N reviews it to delete genetic information, the data from a... discrimination based on genetic information (temporary). 54.9802-3T Section 54.9802-3T Internal Revenue INTERNAL... EXCISE TAXES § 54.9802-3T Additional requirements prohibiting discrimination based on genetic information...

  9. The FR 2 reactor at Karlsruhe, F.R. Germany and associated hot cell facilities. Information sheets

    International Nuclear Information System (INIS)

    Hardt, P. von der; Roettger, H.

    1981-01-01

    Technical information is given on the FR 2 reactor and associated hot cell facilities, specialized irradiation devices (loops and capsules) and possibilities for post-irradiation examinations of samples. The information is presented in the form of eight information sheets under the headings: main characteristics of the reactor; utilization and specialization of the reactor; experimental facilities; neutron spectra; main characteristics of specialized irradiation devices; main characteristics of hot cell facilities; equipment and techniques available for post-irradiation examinations; utilization and specialization of the hot cell facilities

  10. Inositol-Requiring Enzyme 1-Mediated Downregulation of MicroRNA (miR)-146a and miR-155 in Primary Dermal Fibroblasts across Three TNFRSF1A Mutations Results in Hyperresponsiveness to Lipopolysaccharide.

    Science.gov (United States)

    Harrison, Stephanie R; Scambler, Thomas; Oubussad, Lylia; Wong, Chi; Wittmann, Miriam; McDermott, Michael F; Savic, Sinisa

    2018-01-01

    Tumor necrosis factor (TNF)-receptor-associated periodic fever syndrome (TRAPS) is a rare monogenic autoinflammatory disorder characterized by mutations in the TNFRSF1A gene, causing TNF-receptor 1 (TNFR1) misfolding, increased cellular stress, activation of the unfolded protein response (UPR), and hyperresponsiveness to lipopolysaccharide (LPS). Both microRNA (miR)-146a and miR-155 provide negative feedback for LPS-toll-like receptor 2/4 signaling and cytokine production, through regulation of nuclear factor kappa B (NF-κB). In this study, we hypothesized that proinflammatory cytokine signaling in TRAPS downregulates these two miRs, resulting in LPS-induced hyperresponsiveness in TRAPS dermal fibroblasts (DFs), irrespective of the underlying genetic mutation. Primary DF were isolated from skin biopsies of TRAPS patients and healthy controls (HC). TNFR1 cell surface expression was measured using immunofluorescence. DF were stimulated with LPS, interleukin (IL)-1β, thapsigargin, or TNF, with and without inositol-requiring enzyme 1 (IRE1) inhibitor (4u8C), following which miR-146a and miR-155 expression was measured by RT-qPCR. IL-1β, IL-6, and TNF secretion was measured by enzyme-linked immunosorbent assays, and baseline expression of 384 different miRs was assessed using microfluidics assays. TNFR1 was found to be expressed on the surface of HC DF but expression was deficient in all samples with TRAPS-associated mutations. HC DF showed significant dose-dependent increases in both miR-146a and miR-155 expression levels in response to LPS; however, TRAPS DF failed to upregulate either miR-146a or miR-155 under the same conditions. This lack of miR-146a and miR-155 upregulation was associated with increased proinflammatory cytokine production in TRAPS DF in response to LPS challenge, which was abrogated by 4u8C. Incubation of HC DF with IL-1β led to downregulation of miR-146a and miR-155 expression, which was dependent on IRE1 enzyme. We observed global

  11. European Community initiatives and experience in scientific and technical information

    International Nuclear Information System (INIS)

    Steven, G.

    1990-05-01

    Scientific and technical information (STI) is an increasingly important resource for R and D and industrial development. The rapid development of the market for electronic information and the increasing potential offered through new information technologies require new approaches for the collection and dissemination of STI. Activities of the Commission of the European Communities (CEC) in this area are reviewed. More recent CEC initiatives in the areas of biotechnology information and factual materials data banks have proved the need for international collaboration and for the implementation of infrastructural measures as a basis for such collaboration. The implementation of the EC Demonstrator Programme on materials property data systems has evaluated the potential of eleven European materials data banks against the market requirements and has helped to launch wide international collaboration. The concluding European workshop on materials data systems has developed a set of recommendations for future initiatives. These are shortly reviewed together with initial findings of a study aimed at developing a business plan for the establishment of a biotechnology information infrastructure for the bio-industries and research base in Europe. (author). 3 refs

  12. European Community initiatives and experience in scientific and technical information

    Energy Technology Data Exchange (ETDEWEB)

    Steven, G [Commission of the European Communities, Luxembourg (Luxembourg)

    1990-05-01

    Scientific and technical information (STI) is an increasingly important resource for R and D and industrial development. The rapid development of the market for electronic information and the increasing potential offered through new information technologies require new approaches for the collection and dissemination of STI. Activities of the Commission of the European Communities (CEC) in this area are reviewed. More recent CEC initiatives in the areas of biotechnology information and factual materials data banks have proved the need for international collaboration and for the implementation of infrastructural measures as a basis for such collaboration. The implementation of the EC Demonstrator Programme on materials property data systems has evaluated the potential of eleven European materials data banks against the market requirements and has helped to launch wide international collaboration. The concluding European workshop on materials data systems has developed a set of recommendations for future initiatives. These are shortly reviewed together with initial findings of a study aimed at developing a business plan for the establishment of a biotechnology information infrastructure for the bio-industries and research base in Europe. (author). 3 refs.

  13. haploR: an R package for querying web-based annotation tools.

    Science.gov (United States)

    Zhbannikov, Ilya Y; Arbeev, Konstantin; Ukraintseva, Svetlana; Yashin, Anatoliy I

    2017-01-01

    We developed haploR , an R package for querying web based genome annotation tools HaploReg and RegulomeDB. haploR gathers information in a data frame which is suitable for downstream bioinformatic analyses. This will facilitate post-genome wide association studies streamline analysis for rapid discovery and interpretation of genetic associations.

  14. 46 CFR 307.7 - Information required in report.

    Science.gov (United States)

    2010-10-01

    ... information, and (viii) The keyword “MAREP”. If optional remarks are included, they must follow at the end of... (vi) The keyword “MAREP”. If optional remarks are included, they must follow at the end of the text... Radio Call Sign, (iii) Time at reported position, (iv) Latitude and longitude, and (v) The keyword...

  15. User requirements for the Harmonization of Environmental Measurement Information System HEMIS

    International Nuclear Information System (INIS)

    Crain, I.K.

    1992-03-01

    The purpose of this study was to define as much as possible, the functional requirements of the potential main users of the Harmonization of Environmental Measurement Information System, HEMIS. The resulting report is to be used as a basis for a rapid decision on technical approaches to system development, planning of schedule and costs, and to guide the system development and implementation process

  16. What do information reuse and automated processing require in engineering design? Semantic process

    Directory of Open Access Journals (Sweden)

    Ossi Nykänen

    2011-12-01

    Full Text Available Purpose: The purpose of this study is to characterize, analyze, and demonstrate machine-understandable semantic process for validating, integrating, and processing technical design information. This establishes both a vision and tools for information reuse and semi-automatic processing in engineering design projects, including virtual machine laboratory applications with generated components.Design/methodology/approach: The process model has been developed iteratively in terms of action research, constrained by the existing technical design practices and assumptions (design documents, expert feedback, available technologies (pre-studies and experiments with scripting and pipeline tools, benchmarking with other process models and methods (notably the RUP and DITA, and formal requirements (computability and the critical information paths for the generated applications. In practice, the work includes both quantitative and qualitative components.Findings: Technical design processes may be greatly enhanced in terms of semantic process thinking, by enriching design information, and automating information validation and transformation tasks. Contemporary design information, however, is mainly intended for human consumption, and needs to be explicitly enriched with the currently missing data and interfaces. In practice, this may require acknowledging the role of technical information or knowledge engineer, to lead the development of the semantic design information process in a design organization. There is also a trade-off between machine-readability and system complexity that needs to be studied further, both empirically and in theory.Research limitations/implications: The conceptualization of the semantic process is essentially an abstraction based on the idea of progressive design. While this effectively allows implementing semantic processes with, e.g., pipeline technologies, the abstraction is valid only when technical design is organized into

  17. Building a SuAVE browse interface to R2R's Linked Data

    Science.gov (United States)

    Clark, D.; Stocks, K. I.; Arko, R. A.; Zaslavsky, I.; Whitenack, T.

    2017-12-01

    The Rolling Deck to Repository program (R2R) is creating and evaluating a new browse portal based on the SuAVE platform and the R2R linked data graph. R2R manages the underway sensor data collected by the fleet of US academic research vessels, and provides a discovery and access point to those data at its website, www.rvdata.us. R2R has a database-driven search interface, but seeks a more capable and extensible browse interface that could be built off of the substantial R2R linked data resources. R2R's Linked Data graph organizes its data holdings around key concepts (e.g. cruise, vessel, device type, operator, award, organization, publication), anchored by persistent identifiers where feasible. The "Survey Analysis via Visual Exploration" or SuAVE platform (suave.sdsc.edu) is a system for online publication, sharing, and analysis of images and metadata. It has been implemented as an interface to diverse data collections, but has not been driven off of linked data in the past. SuAVE supports several features of interest to R2R, including faceted searching, collaborative annotations, efficient subsetting, Google maps-like navigation over an image gallery, and several types of data analysis. Our initial SuAVE-based implementation was through a CSV export from the R2R PostGIS-enabled PostgreSQL database. This served to demonstrate the utility of SuAVE but was static and required reloading as R2R data holdings grew. We are now working to implement a SPARQL-based ("RDF Query Language") service that directly leverages the R2R Linked Data graph and offers the ability to subset and/or customize output.We will show examples of SuAVE faceted searches on R2R linked data concepts, and discuss our experience to date with this work in progress.

  18. Cognitive Connected Vehicle Information System Design Requirement for Safety: Role of Bayesian Artificial Intelligence

    Directory of Open Access Journals (Sweden)

    Ata Khan

    2013-04-01

    Full Text Available Intelligent transportation systems (ITS are gaining acceptance around the world and the connected vehicle component of ITS is recognized as a high priority research and development area in many technologically advanced countries. Connected vehicles are expected to have the capability of safe, efficient and eco-driving operations whether these are under human control or in the adaptive machine control mode of operations. The race is on to design the capability to operate in connected traffic environment. The operational requirements can be met with cognitive vehicle design features made possible by advances in artificial intelligence-supported methodology, improved understanding of human factors, and advances in communication technology. This paper describes cognitive features and their information system requirements. The architecture of an information system is presented that supports the features of the cognitive connected vehicle. For better focus, information processing capabilities are specified and the role of Bayesian artificial intelligence is defined for data fusion. Example applications illustrate the role of information systems in integrating intelligent technology, Bayesian artificial intelligence, and abstracted human factors. Concluding remarks highlight the role of the information system and Bayesian artificial intelligence in the design of a new generation of cognitive connected vehicle.

  19. Implementation of Waste Minimization at a complex R ampersand D site

    International Nuclear Information System (INIS)

    Lang, R.E.; Thuot, J.R.; Devgun, J.S.

    1995-01-01

    Under the 1994 Waste Minimization/Pollution Prevention Crosscut Plan, the Department of Energy (DOE) has set a goal of 50% reduction in waste at its facilities by the end of 1999. Each DOE site is required to set site-specific goals to reduce generation of all types of waste including hazardous, radioactive, and mixed. To meet these goals, Argonne National Laboratory (ANL), Argonne, IL, has developed and implemented a comprehensive Pollution Prevention/Waste Minimization (PP/WMin) Program. The facilities and activities at the site vary from research into basic sciences and research into nuclear fuel cycle to high energy physics and decontamination and decommissioning projects. As a multidisciplinary R ampersand D facility and a multiactivity site, ANL generates waste streams that are varied, in physical form as well as in chemical constituents. This in turn presents a significant challenge to put a cohesive site-wide PP/WMin Program into action. In this paper, we will describe ANL's key activities and waste streams, the regulatory drivers for waste minimization, and the DOE goals in this area, and we will discuss ANL's strategy for waste minimization and it's implementation across the site

  20. What are the essential competencies required of a midwife at the point of registration?

    Science.gov (United States)

    Butler, Michelle M; Fraser, Diane M; Murphy, Roger J L

    2008-09-01

    to identify the essential competencies required of a midwife at the point of registration. qualitative, descriptive, extended case study and depth interviews. pre-registration midwifery education in England. 39 qualifying midwives, their assessors, midwives and midwife teachers across six higher education institutions, and 20 experienced midwives at two sites. essential competencies were identified relating to (1) being a safe practitioner; (2) having the right attitude; and (3) being an effective communicator. In order to be a safe practitioner, it was proposed that a midwife must have a reasonable degree of self-sufficiency, use up-to-date knowledge in practice, and have self and professional awareness. It was suggested that having the right attitude involves being motivated, being committed to midwifery and being caring and kind. Participants highlighted the importance of effective communication so that midwives can relate to and work in partnership with women and provide truly informed choice. Essential communication skills include active listening, providing appropriate information and flexibility. the most important requirement at registration is that a midwife is safe and will practise safely. However, this capability to be safe is further mediated by attitudes and communication skills. models of midwifery competence should always include personal attributes and effective communication in addition to the competencies required to be able to practise safely, and there should be an explicit focus in curriculum content, skills training and assessment on attitudes and communication.

  1. Development of a website and an information system for an European R&D project : the example of the STRATFEED project

    Directory of Open Access Journals (Sweden)

    Baeten V.

    2003-01-01

    Full Text Available The multidisciplinary nature, the international partnership and the large amount of information to be managed in an European project such as STRATFEED, require the development of an information management system. Within the framework of this project, the development of the Internet-oriented computer system required three facets: the data and information collection, the database building and the development of different applications. A tool for the dissemination of results (STRATFEED website with both a public part and a confidential part, a tool for data management (STRATFEED manager, a tool for data queries (STRATFEED explorer and two tools for decision-making (ARIES Decision Support System –– CD-Rom release and STRATFEED Decision Support System – Internet release were developed. The modular concept, which relates to the different topics of the project, facilitates the updating and development of a system according to research progress and user needs. The concept developed for this project can be used for any other project and can easily be adapted to meet new requirements. The example of the STRATFEED project can be accessed at: http://stratfeed.cra.wallonie.be

  2. 26 CFR 1.852-7 - Additional information required in returns of shareholders.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Additional information required in returns of shareholders. 1.852-7 Section 1.852-7 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Regulated Investment Companies and Real Estate Investment...

  3. 12 CFR 1.5 - Safe and sound banking practices; credit information required.

    Science.gov (United States)

    2010-01-01

    ... interest rate, credit, liquidity, price, foreign exchange, transaction, compliance, strategic, and... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Safe and sound banking practices; credit information required. 1.5 Section 1.5 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE...

  4. 77 FR 74225 - Proposed Extension of the Approval of Information Collection Requirements

    Science.gov (United States)

    2012-12-13

    ... proposal to extend Office of Management and Budget (OMB) approval of the Information Collection: Work-Study... reporting requirements that include a Work Study Program application and written participation agreement. In... private school system to file with the Wage and Hour Division Administrator an application for approval of...

  5. Process-driven information management system at a biotech company: concept and implementation.

    Science.gov (United States)

    Gobbi, Alberto; Funeriu, Sandra; Ioannou, John; Wang, Jinyi; Lee, Man-Ling; Palmer, Chris; Bamford, Bob; Hewitt, Robin

    2004-01-01

    While established pharmaceutical companies have chemical information systems in place to manage their compounds and the associated data, new startup companies need to implement these systems from scratch. Decisions made early in the design phase usually have long lasting effects on the expandability, maintenance effort, and costs associated with the information management system. Careful analysis of work and data flows, both inter- and intradepartmental, and identification of existing dependencies between activities are important. This knowledge is required to implement an information management system, which enables the research community to work efficiently by avoiding redundant registration and processing of data and by timely provision of the data whenever needed. This paper first presents the workflows existing at Anadys, then ARISE, the research information management system developed in-house at Anadys. ARISE was designed to support the preclinical drug discovery process and covers compound registration, analytical quality control, inventory management, high-throughput screening, lower throughput screening, and data reporting.

  6. Competence Requirements of ISO/IEC Standards for Information Security Professionals

    Directory of Open Access Journals (Sweden)

    Natalia G. Miloslavskaya

    2017-11-01

    Full Text Available The rapid progress in the filed of information security (IS puts one in a need of periodic revision of professional competencies (formulated in the federal state educational standards –FSESs and working functions (formulated in the professional standards – PSs. Under these conditions, a timely reaction to everything new that emerges or will appear in modern regulatory documents (primarily in standards is extremely important. We make a forecast for the content of the ISO/IEC 27021 and ISO/IEC 19896 standards drafted by the International Organization for Standardization (ISO, which should contain the requirements for the competencies of IS management system professionals and the competence of IS testers and evaluators. Our forecast takes into account the requirements of the ISO/IEC 27000 standard group and the recommendations of the European e-Competence Framework e-CF 3.0.

  7. 76 FR 66352 - Reports, Forms and Record Keeping Requirements, Agency Information Collection Activity Under OMB...

    Science.gov (United States)

    2011-10-26

    ... original equipment or replacement equipment. Thus, the submitted information about headlamp light sources... devices and associated equipment,'' part 564 submission are referenced as being the source of information... Standard No. 108, ``Lamps Reflective Devices, and Associated Equipment,'' specifies requirements for...

  8. Improving readability of informed consents for research at an academic medical institution.

    Science.gov (United States)

    Hadden, Kristie B; Prince, Latrina Y; Moore, Tina D; James, Laura P; Holland, Jennifer R; Trudeau, Christopher R

    2017-12-01

    The final rule for the protection of human subjects requires that informed consent be "in language understandable to the subject" and mandates that "the informed consent must be organized in such a way that facilitates comprehension." This study assessed the readability of Institutional Review Board-approved informed consent forms at our institution, implemented an intervention to improve the readability of consent forms, and measured the first year impact of the intervention. Readability assessment was conducted on a sample of 217 Institutional Review Board-approved informed consents from 2013 to 2015. A plain language informed consent template was developed and implemented and readability was assessed again after 1 year. The mean readability of the baseline sample was 10th grade. The mean readability of the post-intervention sample (n=82) was seventh grade. Providing investigators with a plain language informed consent template and training can promote improved readability of informed consents for research.

  9. Nucleolin is required for DNA methylation state and the expression of rRNA gene variants in Arabidopsis thaliana.

    Directory of Open Access Journals (Sweden)

    Frédéric Pontvianne

    2010-11-01

    Full Text Available In eukaryotes, 45S rRNA genes are arranged in tandem arrays in copy numbers ranging from several hundred to several thousand in plants. Although it is clear that not all copies are transcribed under normal growth conditions, the molecular basis controlling the expression of specific sets of rRNA genes remains unclear. Here, we report four major rRNA gene variants in Arabidopsis thaliana. Interestingly, while transcription of one of these rRNA variants is induced, the others are either repressed or remain unaltered in A. thaliana plants with a disrupted nucleolin-like protein gene (Atnuc-L1. Remarkably, the most highly represented rRNA gene variant, which is inactive in WT plants, is reactivated in Atnuc-L1 mutants. We show that accumulated pre-rRNAs originate from RNA Pol I transcription and are processed accurately. Moreover, we show that disruption of the AtNUC-L1 gene induces loss of symmetrical DNA methylation without affecting histone epigenetic marks at rRNA genes. Collectively, these data reveal a novel mechanism for rRNA gene transcriptional regulation in which the nucleolin protein plays a major role in controlling active and repressed rRNA gene variants in Arabidopsis.

  10. Present status of two R.F. heating schemes: I.C.R.H. and L.H.R.H

    International Nuclear Information System (INIS)

    Consoli, T.

    1977-01-01

    Among the large number of wave-plasma interaction, Ion-Cyclotron Resonant Heating (I.C.R.H.) and Lower Hybrid Resonant Heating (L.H.R.H.), are two promising additional R.F. heating schemes for toroidal hot plasma. They both offer the advantage of using power generators which requires a moderate development for next generation machines. It seems important to try to state in the limits of this paper the present experimental situation of these two R.F. heating methods as it results from the vast literature published from the last European Conference

  11. Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model

    Science.gov (United States)

    Limmer, Stefanie; Haller, Samantha; Drenkard, Eliana; Lee, Janice; Yu, Shen; Kocks, Christine; Ausubel, Frederick M.; Ferrandon, Dominique

    2011-01-01

    An in-depth mechanistic understanding of microbial infection necessitates a molecular dissection of host–pathogen relationships. Both Drosophila melanogaster and Pseudomonas aeruginosa have been intensively studied. Here, we analyze the infection of D. melanogaster by P. aeruginosa by using mutants in both host and pathogen. We show that orally ingested P. aeruginosa crosses the intestinal barrier and then proliferates in the hemolymph, thereby causing the infected flies to die of bacteremia. Host defenses against ingested P. aeruginosa included an immune deficiency (IMD) response in the intestinal epithelium, systemic Toll and IMD pathway responses, and a cellular immune response controlling bacteria in the hemocoel. Although the observed cellular and intestinal immune responses appeared to act throughout the course of the infection, there was a late onset of the systemic IMD and Toll responses. In this oral infection model, P. aeruginosa PA14 did not require its type III secretion system or other well-studied virulence factors such as the two-component response regulator GacA or the protease AprA for virulence. In contrast, the quorum-sensing transcription factor RhlR, but surprisingly not LasR, played a key role in counteracting the cellular immune response against PA14, possibly at an early stage when only a few bacteria are present in the hemocoel. These results illustrate the power of studying infection from the dual perspective of host and pathogen by revealing that RhlR plays a more complex role during pathogenesis than previously appreciated. PMID:21987808

  12. Understanding the Information Requirements of Arts and Humanities Scholarship

    Directory of Open Access Journals (Sweden)

    Agiatis Benardou

    2010-07-01

    Full Text Available This paper reports on research of scholarly research practices and requirements conducted in the context of the Preparing DARIAH European e-Infrastructures project, with a view to ensuring current and future fitness for purpose of the planned digital infrastructure, services and tools. It summarises the findings of earlier research, primarily from the field of human information behaviour as applied in scholarly work, it presents a conceptual perspective informed by cultural-historical activity theory, it introduces briefly a formal conceptual model for scholarly research activity compliant with CIDOC CRM, it describes the plan of work and methodology of an empirical research project based on open-questionnaire interviews with arts and humanities researchers, and presents illustrative examples of segmentation, tagging and initial conceptual analysis of the empirical evidence. Finally, it presents plans for future work, consisting, firstly, of a comprehensive re-analysis of interview segments within the framework of the scholarly research activity model, and, secondly, of the integration of this analysis with the extended digital curation process model we presented in earlier work.

  13. The receptor-like kinase SOBIR1 interacts with Brassica napus LepR3 and is required for Leptosphaeria maculans AvrLm1-triggered immunity

    Directory of Open Access Journals (Sweden)

    Lisong eMa

    2015-10-01

    Full Text Available AbstractThe fungus Leptosphaeria maculans (L. maculans is the causal agent of blackleg disease of canola/oilseed rape (Brassica napus worldwide. We previously reported cloning of the B. napus blackleg resistance gene, LepR3, which encodes a receptor-like protein. LepR3 triggers localised cell death upon recognition of its cognate Avr protein, AvrLm1. Here, we exploited the Nicotiana benthamiana model plant to investigate the recognition mechanism of AvrLm1 by LepR3. Co-expression of the LepR3/AvrLm1 gene pair in N. benthamiana resulted in development of a hypersensitive response (HR. However, a truncated AvrLm1 lacking its indigenous signal peptide was compromised in its ability to induce LepR3-mediated HR, indicating that AvrLm1 is perceived by LepR3 extracellularly. Structure-function analysis of the AvrLm1 protein revealed that the C-terminal region of AvrLm1 was required for LepR3-mediated HR in N. benthamiana and for resistance to L. maculans in B. napus. LepR3 was shown to be physically interacting with the B. napus receptor like kinase, SOBIR1 (BnSOBIR1. Silencing of NbSOBIR1 or NbSERK3 (BAK1 compromised LepR3-AvrLm1-dependent HR in N. benthamiana, suggesting that LepR3-mediated resistance to L. maculans in B. napus requires SOBIR1 and BAK1/SERK3. Using this model system, we determined that BnSOBIR1 and SERK3/BAK1 are essential partners in the LepR3 signalling complex and were able to define the AvrLm1 effector domain.

  14. Parallel photonic information processing at gigabyte per second data rates using transient states

    Science.gov (United States)

    Brunner, Daniel; Soriano, Miguel C.; Mirasso, Claudio R.; Fischer, Ingo

    2013-01-01

    The increasing demands on information processing require novel computational concepts and true parallelism. Nevertheless, hardware realizations of unconventional computing approaches never exceeded a marginal existence. While the application of optics in super-computing receives reawakened interest, new concepts, partly neuro-inspired, are being considered and developed. Here we experimentally demonstrate the potential of a simple photonic architecture to process information at unprecedented data rates, implementing a learning-based approach. A semiconductor laser subject to delayed self-feedback and optical data injection is employed to solve computationally hard tasks. We demonstrate simultaneous spoken digit and speaker recognition and chaotic time-series prediction at data rates beyond 1Gbyte/s. We identify all digits with very low classification errors and perform chaotic time-series prediction with 10% error. Our approach bridges the areas of photonic information processing, cognitive and information science.

  15. The Establishment of a Management Information Systems Research Center at the Naval Postgraduate School

    Science.gov (United States)

    1989-09-01

    Project WP 88-03 GDSS Technology in Practice: A Study D. Straub R. Beauclair WP 88-04 Interaction Analysis in GDSS Research: I. Zigurs Description of an...03 GDSS Technology in Practice: A Study (D. Straub and R. Beauclair ) 4. WP 88-04 Interaction Analysis in GDSS Research: Description of an Experience...Implementing an Information Architecture," Data Base, forthcoming. 25 Straub, D. W. and R. A. Beauclair . "A New Dimension to Decision Support

  16. Infochemistry Information Processing at the Nanoscale

    CERN Document Server

    Szacilowski, Konrad

    2012-01-01

    Infochemistry: Information Processing at the Nanoscale, defines a new field of science, and describes the processes, systems and devices at the interface between chemistry and information sciences. The book is devoted to the application of molecular species and nanostructures to advanced information processing. It includes the design and synthesis of suitable materials and nanostructures, their characterization, and finally applications of molecular species and nanostructures for information storage and processing purposes. Divided into twelve chapters; the first three chapters serve as an int

  17. 78 FR 73237 - Reports, Forms and Record Keeping Requirements Agency Information Collection Activity Under OMB...

    Science.gov (United States)

    2013-12-05

    ...-0088] Reports, Forms and Record Keeping Requirements Agency Information Collection Activity Under OMB... entities over which the agency exercises regulatory authority. Recent trends lead the agency to estimate.... Requesters are not required to keep copies of any records or reports [[Page 73238

  18. Search for stop production in R-parity-violating supersymmetry at HERA

    International Nuclear Information System (INIS)

    Chekanov, S.; Derrick, M.; Magill, S.

    2006-11-01

    A search for stop production in R-parity-violating supersymmetry has been performed in e + p interactions with the ZEUS detector at HERA, using an integrated luminosity of 65 pb -1 . At HERA, the R-parity-violating coupling λ' allows resonant squark production, e + d→q. Since the lowest-mass squark state in most supersymmetry models is the light stop, t, this search concentrated on production of t, followed either by a direct R-parity-violating decay, or by the gauge decay to b χ 1 + . No evidence for stop production was found and limits were set on λ 131 ' as a function of the stop mass in the framework of the Minimal Supersymmetric Standard Model. The results have also been interpreted in terms of constraints on the parameters of the minimal Supergravity model. (orig.)

  19. Supplemental Information for New York State Standardized Interconnection Requirements

    Energy Technology Data Exchange (ETDEWEB)

    Ingram, Michael [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Narang, David J. [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Mather, Barry A. [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Kroposki, Benjamin D. [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-10-24

    This document is intended to aid in the understanding and application of the New York State Standardized Interconnection Requirements (SIR) and Application Process for New Distributed Generators 5 MW or Less Connected in Parallel with Utility Distribution Systems, and it aims to provide supplemental information and discussion on selected topics relevant to the SIR. This guide focuses on technical issues that have to date resulted in the majority of utility findings within the context of interconnecting photovoltaic (PV) inverters. This guide provides background on the overall issue and related mitigation measures for selected topics, including substation backfeeding, anti-islanding and considerations for monitoring and controlling distributed energy resources (DER).

  20. Data Visualization and Infographics In Visual Communication Design Education at The Age of Information

    Directory of Open Access Journals (Sweden)

    Banu Inanc Uyan Dur

    2014-06-01

    Full Text Available Scientific and technologic developments in the last century facilitate people’s lives while also causing them to face more information. Information design has become much more important as a result of the chaos created by the unprocessed heap of data and information traffic. Therefore, people need designed information like infographics and data visualisation today. Design of information, which is among the most significant requirements of our age, has become a subject which needs to be dealt with more systematically in the education of visual communication design. Visual design of information and data is important not only for increasing perceptibility but also revealing the patterns within complex information, and being educative, persuasive and guiding depending on the content and objective. In this sense, incorporating data visualization and infographics works into the education of visual communication design would have significant contributions to train designers with sufficient qualification to meet the requirements of today’s world. This study examines the current/potential expansion of data visualization and infographics in the education of visual communication design  at the age of information. With respect to students, it deals with its effects to the design method, process and perception and its contributions to the multidisciplinary design approach.

  1. Substitution of the CFCs R-11, R-13, R-503, R-13B1, R-113, R-114 and R-12B1 in existing refrigerating, air-conditioning and heat pump systems with refrigerants of low ozone depletion potential in the Federal Republic of Germany. Status report; Ersatz der FCKW R11, R13, R503, R13B1, R113, R114, und R12B1 in bestehenden Kaelte-, Klima- und Waermepumpenanlagen in der Bundesrepublik Deutschland durch Kaeltemittel mit geringem Ozonabbaupotential. Statusbericht

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-11-01

    The technical basics and the state of the art for the substitution of the CFC refrigerants R-11, R-13, R-503, R-13B1, R-113, R-114 and R-12B1 in existing refrigeration systems are described and explained. The report contains an overview of the current applications of these refrigerants in the FRG, a review and discussion of existing substitutes, the presentation and evaluation of research and experiences with the conversion to alternative refrigerants, the presentation of the required infrastructure and a discussion of the technical feasibility. The conversion of existing systems to refrigerants of lower ozone depletion potential is in conclusion evaluated with regard to its technical feasibility, environmental relevance and economic efficiency. (orig.) [Deutsch] Es werden die technischen Grundlagen und der Stand der Technik zum Ersatz der FCKW-Kaeltemittel R11, R13, R503, R13B1, R113, R114 und R12B1 in bestehenden Kaelteanlagen dargestellt und erlaeutert. Der Bericht beinhaltet einen Ueberblick ueber die derzeitige Anwendung dieser Kaeltemittel in der BRD, die Vorstellung und Diskussion existierender Ersatzstoffe, die Darstellung und Bewertung der Forschung und Erfahrungen zu Umruestungen auf Ersatzstoffe, die Vorstellung der erforderlichen Infrastruktur und die Diskussion der technischen Durchfuehrbarkeit. Die Umstellung bestehender Anlagen auf Kaeltemittel mit geringerem Ozonabbaupotential wird abschliessend hinsichtlich der technischen Durchfuehrbarkeit, der Umweltrelevanz und der Wirtschaftlichkeit bewertet. (orig.)

  2. Guaranteed safety information for rising traffic safety at roads main junctions using infrastructure-aided driver-assistance systems; Sichere Information durch infrastrukturgestuetzte Fahrerassistenzsysteme zur Steigerung der Verkehrssicherheit an Strassenknotenpunkten

    Energy Technology Data Exchange (ETDEWEB)

    Wiltschko, T.

    2004-07-01

    Progress of development of driver assistance systems have more and more lead to systems assisting the driver on guidance level. These systems allow direct or indirect driving process contact thus being safety relevant vehicle systems, and their operation requires high safety and reliability standards. To realize the necessary driver assistance, complete collection and interpretation of traffic actions are required and a number of information and information sources has to be integrated, especially in case of traffic situations at junctions in urban areas. The requirements, however, cannot only be reduced to technical reliability of the system and system components but have also to be extended to the information in- and output thus guaranteeing safe operation. This information has to reach the required quality thus avoiding any hazards during the complete time of information use. It is evident that none of the existing models and methods allow a uniform description of information quality of driver assistance systems. The thesis shows a quality concept for description and evaluation of information quality within information processing systems. The quality concept consists of a quality model and an analysing procedure. The quality model is the basis of the quality concept. All types of information are described by a fixed set of quality characteristic, and suitable parameters are used for concretion and quantification. (orig.)

  3. 19 CFR 122.48a - Electronic information for air cargo required in advance of arrival.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Electronic information for air cargo required in... OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Aircraft Entry and Entry Documents; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard...

  4. Informed choice requires information about both benefits and harms

    DEFF Research Database (Denmark)

    Jørgensen, K J; Brodersen, J; Hartling, O J

    2009-01-01

    women is seriously biased in favour of participation. Women are not informed about the major harms of screening, and the decision to attend has already been made for them by a public authority. This short-circuits informed decision-making and the legislation on informed consent, and violates...... the autonomy of the women. Screening invitations must present both benefits and harms in a balanced fashion, and should offer, not encourage, participation. It should be stated clearly that the choice not to participate is as sensible as the choice to do so. To allow this to happen, the responsibility...

  5. Identification of the subunit of cAMP receptor protein (CRP) that functionally interacts with CytR in CRP-CytR-mediated transcriptional repression

    DEFF Research Database (Denmark)

    Meibom, K L; Kallipolitis, B H; Ebright, R H

    2000-01-01

    At promoters of the Escherichia coli CytR regulon, the cAMP receptor protein (CRP) interacts with the repressor CytR to form transcriptionally inactive CRP-CytR-promoter or (CRP)(2)-CytR-promoter complexes. Here, using "oriented heterodimer" analysis, we show that only one subunit of the CRP dimer......, the subunit proximal to CytR, functionally interacts with CytR in CRP-CytR-promoter and (CRP)(2)-CytR-promoter complexes. Our results provide information about the architecture of CRP-CytR-promoter and (CRP)(2)-CytR-promoter complexes and rule out the proposal that masking of activating region 2 of CRP...

  6. Broken R-parity in the sky an at the LHC

    International Nuclear Information System (INIS)

    Bobrovskyi, S.; Buchmueller, W.; Hajer, J.; Schmidt, J.

    2010-07-01

    Supersymmetric extensions of the Standard Model with small R-parity and lepton number violating couplings are naturally consistent with primordial nucleosynthesis, thermal leptogenesis and gravitino dark matter. We consider supergravity models with universal boundary conditions at the grand unification scale, and scalar τ-lepton or bino-like neutralino as next-to-lightest superparticle (NLSP). Recent Fermi-LAT data on the isotropic diffuse gamma-ray flux yield a lower bound on the gravitino lifetime. Comparing two-body gravitino and neutralino decays we find a lower bound on a neutralino NLSP decay length, cτ χ 0 1 >or similar 30 cm. Together with gravitino and neutralino masses one obtains a microscopic determination of the Planck mass. For a τ-NLSP there exists no model-independent lower bound on the decay length. Here the strongest bound comes from the requirement that the cosmological baryon asymmetry is not washed out, which yields cτ τ 1 >or similar 4 mm. However, without fine-tuning of parameters, one finds much larger decay lengths. For typical masses, m 3/2 ∝ 100 GeV and m NLSP ∝150 GeV, the discovery of a photon line with an intensity close to the Fermi-LAT limit would imply a decay length cτ NLSP of several hundred meters, which can be measured at the LHC. (orig.)

  7. Provision of a draft version for standard classification structure for information of radiation technologies through analyzing their information and derivation of its applicable requirements to the information system

    International Nuclear Information System (INIS)

    Jang, Sol Ah; Kim, Joo Yeon; Yoo, Ji Yup; Shin, Woo Ho; Park, Tai Jin; Song, Myung Jae

    2015-01-01

    Radiation technology is the one for developing new products or processes by applying radiation or for creating new functions in industry, research and medical fields, and its application is increasing consistently. For securing an advanced technology competitiveness, it is required to create a new added value by information consumer through providing an efficient system for supporting information, which is the infrastructure for research and development, contributed to its collection, analysis and use with a rapidity and structure in addition to some direct research and development. Provision of the management structure for information resources is especially crucial for efficient operating the system for supporting information in radiation technology, and then a standard classification structure of information must be first developed as the system for supporting information will be constructed. The standard classification structure has been analyzed by reviewing the definition of information resources in radiation technology, and those classification structures in similar systems operated by institute in radiation and other scientific fields. And, a draft version of the standard classification structure has been then provided as 7 large, 25 medium and 71 small classifications, respectively. The standard classification structure in radiation technology will be developed in 2015 through reviewing this draft version and experts' opinion. Finally, developed classification structure will be applied to the system for supporting information by considering the plan for constructing this system and database, and requirements for designing the system. Furthermore, this structure will be designed in the system for searching information by working to the individual need of information consumers

  8. Provision of a draft version for standard classification structure for information of radiation technologies through analyzing their information and derivation of its applicable requirements to the information system

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Sol Ah; Kim, Joo Yeon; Yoo, Ji Yup; Shin, Woo Ho; Park, Tai Jin; Song, Myung Jae [Korean Association for Radiation Application, Seoul (Korea, Republic of)

    2015-02-15

    Radiation technology is the one for developing new products or processes by applying radiation or for creating new functions in industry, research and medical fields, and its application is increasing consistently. For securing an advanced technology competitiveness, it is required to create a new added value by information consumer through providing an efficient system for supporting information, which is the infrastructure for research and development, contributed to its collection, analysis and use with a rapidity and structure in addition to some direct research and development. Provision of the management structure for information resources is especially crucial for efficient operating the system for supporting information in radiation technology, and then a standard classification structure of information must be first developed as the system for supporting information will be constructed. The standard classification structure has been analyzed by reviewing the definition of information resources in radiation technology, and those classification structures in similar systems operated by institute in radiation and other scientific fields. And, a draft version of the standard classification structure has been then provided as 7 large, 25 medium and 71 small classifications, respectively. The standard classification structure in radiation technology will be developed in 2015 through reviewing this draft version and experts' opinion. Finally, developed classification structure will be applied to the system for supporting information by considering the plan for constructing this system and database, and requirements for designing the system. Furthermore, this structure will be designed in the system for searching information by working to the individual need of information consumers.

  9. R quick syntax reference

    CERN Document Server

    Tollefson, Margot

    2014-01-01

    The R Quick Syntax Reference is a handy reference book detailing the intricacies of the R language. Not only is R a free, open-source tool, R is powerful, flexible, and has state of the art statistical techniques available. With the many details which must be correct when using any language, however, the R Quick Syntax Reference makes using R easier.Starting with the basic structure of R, the book takes you on a journey through the terminology used in R and the syntax required to make R work. You will find looking up the correct form for an expression quick and easy. With a copy of the R Quick

  10. Information System Passive Safety at DaimlerChrysler: from vision to reality

    Energy Technology Data Exchange (ETDEWEB)

    Ruoff, H. [DaimlerChrysler AG, Sindelfingen (Germany)

    2001-07-01

    Today, short development times and an extensive model range are key factors when it comes to remaining a leading force in the highly competitive automobile market. Information technology plays a crucial role as an 'enabler' in keeping this competitive edge. It is only possible to make full use of existing potential by using 'state-of-the-art' information technology. In particular, this involves making knowledge that is distributed in various systems and 'heads' available quickly and transparently anytime and anywhere. The improved re-use of acquired expertise, efficient information searches, and standardized and seamless applications lead to a high level of performance. This often involves the transformation of a company culture from 'information hider' to 'information provider'. The vision of converting a gradually created, complex range of systems into a seamless sequence of distributed working processes with numerous participants is becoming reality in the Passive Safety area in Automobile/Vehicle Development at DaimlerChrysler. The INFOS Passive Safety information system provides all the data and information, which is required for, or results from, the entire crash test process. (orig.)

  11. User requirements for information systems in nuclear medicine

    Energy Technology Data Exchange (ETDEWEB)

    Todd-Pokropek, A. (University Coll., London (United Kingdom)); Vauramo, E.; Sippo-Tujunen, I. (Helsinki City Health Dept. (Finland)); Cosgriff, P. (Pilgrim Hospital, Boston (UK)); Britton, K. (Saint Bartholomew' s Hospital, London (United Kingdom))

    1992-05-01

    In the field of COST cooperation (COST = European Cooperation in the Field of Scientific and Technical Research) a project B2 for Quality Assurance in Nuclear Medicine Software has been established. In a memorandum of understanding setting up this project, user requirements were to be defined for the hardware and software used for data acquisition, processing and presentation. A subgroup of the management committee of COST B2 were interested in the Advanced Informatics in Medicine, AIM, task T-734 'Quality Assurance of Medical Software', and the AIM Project 'A 1034', coordinated by Dr. K. Britton, was initiated. The initial drafts of this document were written in Helsinki during 1988-1990, and submitted for comment by the members of the management committee of COST B2. These comments were integrated in the text and this document was finalized by the UK group so as to make it available for international discussion. It is anticipated that, after appropriate international discussion, these User Requirements for Information Systems in Nuclear Medicine will be adopted by the management committee of COST B2 as a COST document. Towards these ends, a working group chaired by Dr Britton, including the British and Finnish teams and Ulrich Noelpp from Switzerland, was appointed by the management committee of COST B2 in April 1990. (Author).

  12. User requirements for information systems in nuclear medicine

    International Nuclear Information System (INIS)

    Todd-Pokropek, A.; Vauramo, E.; Sippo-Tujunen, I.; Cosgriff, P.; Britton, K.

    1992-01-01

    In the field of COST cooperation (COST = European Cooperation in the Field of Scientific and Technical Research) a project B2 for Quality Assurance in Nuclear Medicine Software has been established. In a memorandum of understanding setting up this project, user requirements were to be defined for the hardware and software used for data acquisition, processing and presentation. A subgroup of the management committee of COST B2 were interested in the Advanced Informatics in Medicine, AIM, task T-734 'Quality Assurance of Medical Software', and the AIM Project 'A 1034', coordinated by Dr. K. Britton, was initiated. The initial drafts of this document were written in Helsinki during 1988-1990, and submitted for comment by the members of the management committee of COST B2. These comments were integrated in the text and this document was finalized by the UK group so as to make it available for international discussion. It is anticipated that, after appropriate international discussion, these User Requirements for Information Systems in Nuclear Medicine will be adopted by the management committee of COST B2 as a COST document. Towards these ends, a working group chaired by Dr Britton, including the British and Finnish teams and Ulrich Noelpp from Switzerland, was appointed by the management committee of COST B2 in April 1990. (Author)

  13. Computer-aided design of multi-target ligands at A1R, A2AR and PDE10A, key proteins in neurodegenerative diseases.

    Science.gov (United States)

    Kalash, Leen; Val, Cristina; Azuaje, Jhonny; Loza, María I; Svensson, Fredrik; Zoufir, Azedine; Mervin, Lewis; Ladds, Graham; Brea, José; Glen, Robert; Sotelo, Eddy; Bender, Andreas

    2017-12-30

    Compounds designed to display polypharmacology may have utility in treating complex diseases, where activity at multiple targets is required to produce a clinical effect. In particular, suitable compounds may be useful in treating neurodegenerative diseases by promoting neuronal survival in a synergistic manner via their multi-target activity at the adenosine A 1 and A 2A receptors (A 1 R and A 2A R) and phosphodiesterase 10A (PDE10A), which modulate intracellular cAMP levels. Hence, in this work we describe a computational method for the design of synthetically feasible ligands that bind to A 1 and A 2A receptors and inhibit phosphodiesterase 10A (PDE10A), involving a retrosynthetic approach employing in silico target prediction and docking, which may be generally applicable to multi-target compound design at several target classes. This approach has identified 2-aminopyridine-3-carbonitriles as the first multi-target ligands at A 1 R, A 2A R and PDE10A, by showing agreement between the ligand and structure based predictions at these targets. The series were synthesized via an efficient one-pot scheme and validated pharmacologically as A 1 R/A 2A R-PDE10A ligands, with IC 50 values of 2.4-10.0 μM at PDE10A and K i values of 34-294 nM at A 1 R and/or A 2A R. Furthermore, selectivity profiling of the synthesized 2-amino-pyridin-3-carbonitriles against other subtypes of both protein families showed that the multi-target ligand 8 exhibited a minimum of twofold selectivity over all tested off-targets. In addition, both compounds 8 and 16 exhibited the desired multi-target profile, which could be considered for further functional efficacy assessment, analog modification for the improvement of selectivity towards A 1 R, A 2A R and PDE10A collectively, and evaluation of their potential synergy in modulating cAMP levels.

  14. Information Requirements for the VIMS (Vehicle Integrated Management System).

    Science.gov (United States)

    1983-09-01

    flj the decision setting and the...rl 4-1 -o to SH 0 en X r4 4J <D +J (U 4-1 3 s <u 3 a) r-\\ X 0 U H Jo (0 T3 (Ö TD <tf 0 +J c X i. 1 tt a C" rtJ rH XI x; X CO (0 Cn -4-1 i...tr •H CO en (0 CO •H <u rH O •H a CU > CU x: +j Ä O •H JC O 4J c o •P 4J td N •H C (TJ Oi P o P O CU CT> CO CO

  15. Performance evaluation of Siemens E.CAM(R) SPECT system at Korle-Bu Teaching Hospital (Ghana)

    International Nuclear Information System (INIS)

    Sosu, E.K.; Hasford, F.; Amuasi, J.H.

    2011-01-01

    Performance evaluation tests on Siemens e.cam(R) Signature Series Single Photon Emission Computed Tomography (SPECT)System at Korle-Bu Teaching Hospital (Ghana) were conducted for compliance with Manufacturer's specifications and user's requirements. The tests were performed according to National Electrical Manufacturer's Association protocols, and different measuring instruments and phantoms containing 99m-Tc were used. Extrinsic uniformity, system energy resolution, system spatial resolution (without scattering), detector shield leakage and system planar sensitivity were evaluated. The system energy resolution measured was 9.38 % as against manufacturer's specification of ≤ 9.9 %, Planar sensitivity value measured was 232.92 c/min/mCi while manufacturers' specification was 202 c/min/mCi, and detector shield leakage values measured were 0.001 %, 0.002 % and 0.025 % against an accepted value of < 1 %. The performance evaluation confirmed that the system met requirements for clinical nuclear medicine imaging, and the values could be used as database for future quality control measurements. (au)

  16. Detailed requirements document for common software of shuttle program information management system

    Science.gov (United States)

    Everette, J. M.; Bradfield, L. D.; Horton, C. L.

    1975-01-01

    Common software was investigated as a method for minimizing development and maintenance cost of the shuttle program information management system (SPIMS) applications while reducing the time-frame of their development. Those requirements satisfying these criteria are presented along with the stand-alone modules which may be used directly by applications. The SPIMS applications operating on the CYBER 74 computer, are specialized information management systems which use System 2000 as a data base manager. Common software provides the features to support user interactions on a CRT terminal using form input and command response capabilities. These features are available as subroutines to the applications.

  17. r det er svært at være ung i DK

    DEFF Research Database (Denmark)

    Nielsen, Jens Christian; Sørensen, Niels Ulrik

    r det er svært at være ung i DK – viden og råd om unges trivsel og mistrivsel er afslutningen på et større forskningsprojekt om unges trivsel og mistrivsel. Hæftet præsenterer forskningsprojektets hovedkonklusioner og giver desuden en række råd og ideer til, hvordan voksne kan hjælpe unge med...... at håndtere mistrivsel. Hæftet er udarbejdet af forskerne Jens Christian Nielsen og Niels Ulrik Sørensen fra Center for Ungdomsforskning. Det er den sidste publikation i forskningsprojektet Når det er svært at være ung i DK, der fra 2008-2011 har belyst unges trivsel og mistrivsel. Projektet bygger både på en...

  18. Overlay networks toward information networking

    CERN Document Server

    Tarkoma, Sasu

    2010-01-01

    With their ability to solve problems in massive information distribution and processing, while keeping scaling costs low, overlay systems represent a rapidly growing area of R&D with important implications for the evolution of Internet architecture. Inspired by the author's articles on content based routing, Overlay Networks: Toward Information Networking provides a complete introduction to overlay networks. Examining what they are and what kind of structures they require, the text covers the key structures, protocols, and algorithms used in overlay networks. It reviews the current state of th

  19. 50 CFR 23.25 - What additional information is required on a non-Party CITES document?

    Science.gov (United States)

    2010-10-01

    ... a non-Party CITES document? 23.25 Section 23.25 Wildlife and Fisheries UNITED STATES FISH AND... IN ENDANGERED SPECIES OF WILD FAUNA AND FLORA (CITES) Prohibitions, Exemptions, and Requirements § 23.25 What additional information is required on a non-Party CITES document? (a) Purpose. Under Article...

  20. Compatibility of DOE energy data bases with EEMIS data requirements. [Energy Emergency Management Information Systems

    Energy Technology Data Exchange (ETDEWEB)

    D& #x27; Acierno, J; Hermelee, A

    1979-12-01

    Object of this report is to present the data from EIA data bases which are compatible with the requirements of the data structure for the Energy Emergency Management Information System (EEMIS). An overview of data availability is briefly described and presented in the EEMIS petroleum and natural gas flow diagrams as well as in a more detailed review with each data element in the EEMIS data requirements. This information is presented with the intent that it be used as an overall system guide during the data transfer task as well as in future operation of EEMIS and in the interpretation of EEMIS data.

  1. 75 FR 61244 - Proposed Collection; Comment Request for Form 8038-R

    Science.gov (United States)

    2010-10-04

    ... 8038-R AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... Form 8038-R, Request for Recovery of Overpayments Under Arbitrage Rebate Provisions. DATES: Written... information or copies of the form and instructions should be directed to R. Joseph Durbala at Internal Revenue...

  2. Advances in second generation high temperature superconducting wire manufacturing and R and D at American Superconductor Corporation

    Energy Technology Data Exchange (ETDEWEB)

    Rupich, Martin W; Li Xiaoping; Thieme, Cees; Sathyamurthy, Srivatsan; Fleshler, Steven; Tucker, David; Thompson, Elliot; Schreiber, Jeff; Lynch, Joseph; Buczek, David; DeMoranville, Ken; Inch, James; Cedrone, Paul; Slack, James, E-mail: mrupich@amsc.co [American Superconductor Corporation, 64 Jackson Road, Devens, MA 01434-4020 (United States)

    2010-01-15

    The RABiTS(TM)/MOD-YBCO (rolling assisted biaxially textured substrate/metal-organic deposition of YBa{sub 2}Cu{sub 3}O{sub 7-{delta}}) route has been established as a low-cost manufacturing process for producing high performance second generation (2G) wire. American Superconductor Corporation (AMSC) has used this approach to establish a production scale manufacturing line based on a wide-web manufacturing process. This initial production line is currently capable of producing 2G wire in lengths to 500 m with critical currents exceeding 250 A cm{sub width}{sup -1} at 77 K, in the self-field. The wide-web process, combined with slitting and lamination processes, allows customization of the 2G wire width and stabilizer composition to meet application specific wire requirements. The production line is currently supplying 2G wire for multiple cable, fault current limiter and coil applications. Ongoing R and D is focused on the development of thicker YBCO layers and improved flux pinning centers. This paper reviews the history of 2G wire development at AMSC, summarizes the current capability of the 2G wire manufacturing at AMSC, and describes future R and D improvements.

  3. Hereditary folate malabsorption: A positively charged amino acid at position 113 of the proton-coupled folate transporter (PCFT/SLC46A1) is required for folic acid binding

    International Nuclear Information System (INIS)

    Lasry, Inbal; Berman, Bluma; Glaser, Fabian; Jansen, Gerrit; Assaraf, Yehuda G.

    2009-01-01

    The proton-coupled folate transporter (PCFT/SLC46A1) mediates intestinal folate uptake at acidic pH. Some loss of folic acid (FA) transport mutations in PCFT from hereditary folate malabsorption (HFM) patients cluster in R113, thereby suggesting a functional role for this residue. Herein, unlike non-conservative substitutions, an R113H mutant displayed 80-fold increase in the FA transport Km while retaining parental Vmax, hence indicating a major fall in folate substrate affinity. Furthermore, consistent with the preservation of 9% of parental transport activity, R113H transfectants displayed a substantial decrease in the FA growth requirement relative to mock transfectants. Homology modeling based on the crystal structures of the Escherichia coli transporter homologues EmrD and glycerol-3-phosphate transporter revealed that the R113H rotamer properly protrudes into the cytoplasmic face of the minor cleft normally occupied by R113. These findings constitute the first demonstration that a basic amino acid at position 113 is required for folate substrate binding.

  4. R ampersand D activities at DOE applicable to mixed waste

    International Nuclear Information System (INIS)

    Erickson, M.D.; Devgun, J.S.; Brown, J.J.; Beskid, N.J.

    1991-01-01

    The Department of Energy (DOE) has established the Office of Environmental Restoration and Waste Management. Within the new organization, the Office of Technology Development (OTD) is responsible for research, development, demonstration, testing and evaluation (RDDT ampersand E) activities aimed at meeting DOE cleanup goals, while minimizing cost and risk. Because of US governmental activities dating back to the Manhattan project, mixed radioactive and hazardous waste is an area of particular concern to DOE. The OTD is responsible for a number of R ampersand D activities aimed at improving capabilities to characterize, control, and properly dispose of mixed waste. These activities and their progress to date will be reviewed. In addition, needs for additional R ampersand D on managing mixed waste will be presented. 5 refs., 2 tabs

  5. Search for stop production in R-parity-violating supersymmetry at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Chekanov, S.; Derrick, M.; Magill, S. [Argonne National Laboratory, IL (US)] (and others)

    2006-11-15

    A search for stop production in R-parity-violating supersymmetry has been performed in e{sup +}p interactions with the ZEUS detector at HERA, using an integrated luminosity of 65 pb{sup -1}. At HERA, the R-parity-violating coupling {lambda}' allows resonant squark production, e{sup +}d{yields}q. Since the lowest-mass squark state in most supersymmetry models is the light stop, t, this search concentrated on production of t, followed either by a direct R-parity-violating decay, or by the gauge decay to b{sub {chi}{sub 1}}{sup +}. No evidence for stop production was found and limits were set on {lambda}{sub 131}' as a function of the stop mass in the framework of the Minimal Supersymmetric Standard Model. The results have also been interpreted in terms of constraints on the parameters of the minimal Supergravity model. (orig.)

  6. Risk assessment and mitigation at the information technology companies

    Directory of Open Access Journals (Sweden)

    Ben Marx

    2016-05-01

    Full Text Available Developing computer software that is free from material defects is the ultimate goal for software developers; however, due to the cost and complexity of software development, it is a goal that is unlikely to be achieved. As a consequence of the inevitable defects that manifest within computer software, the task of software patch management becomes a key focus area for software companies, IT departments, and even end users. Audit departments, as part of their responsibilities, are required to provide assurance on the patching process and therefore need to understand the various decision-making factors. Software flaws that exist within computer systems may put confidential information at risk and may also compromise the availability of such systems. The study investigated the recommended approaches for the task of software patching, with a view to balancing the sometimes conflicting requirements of security and system availability. The study found that there are a number of key aspects that are required to ensure a successful patching process and that the internal auditors of the ‘big four’ South African banks considered most of these factors to be important

  7. Insight into the structural requirement of substituted quinazolinone biphenyl acylsulfonamides derivatives as Angiotensin II AT1 receptor antagonist: 2D and 3D QSAR approach

    Directory of Open Access Journals (Sweden)

    Mukesh C. Sharma

    2014-01-01

    Full Text Available A series of 19 molecules substituted quinazolinone biphenyl acylsulfonamides derivatives displaying variable inhibition of Angiotensin II receptor AT1 activity were selected to develop models for establishing 2D and 3D QSAR. The compounds in the selected series were characterized by spatial, molecular and electro topological descriptors using QSAR module of Molecular Design Suite (VLife MDS™ 3.5. The best 2D QSAR model was selected, having correlation coefficient r2 (0.8056 and cross validated squared correlation coefficient q2 (0.6742 with external predictive ability of pred_r2 0.7583 coefficient of correlation of predicted data set (pred_r2se 0.2165. The results obtained from QSAR studies could be used in designing better Ang II activity among the congeners in future. The optimum QSAR model showed that the parameters SsssCHE index, SddCE-index, T_2_Cl_4, and SssNHE-index contributed in the model. 3D QSAR analysis by kNN-molecular field analysis approach developed based on principles of the k-nearest neighbor method combined with Genetic algorithms, stepwise forward variable selection approach; a leave-one-out cross-validated correlation coefficient (q2 of 0.6516 and a non-cross-validated correlation coefficient (r2 of 0.8316 and pred_r2 0.6954 were obtained. Contour maps using this approach showed that steric, electrostatic, and hydrophobic field effects dominantly determine binding affinities. The information rendered by 3D QSAR models may lead to a better understanding of structural requirements of Angiotensin II receptor and can help in the design of novel potent antihypertensive molecules.

  8. A Study of Organizational Information Search, Acquisition, Storage and Retrieval

    Science.gov (United States)

    1986-08-01

    on organizational structures and processes are akin to the effects on the coping behaviors of individuals (Driver and Streufert, 1969; Farace , Monge...Crriizaiiorial Environment. Human Relations, 18: 21-32. Farace , R.B., Monge, P. R., & Russell, H. M. 1977. Crnmunicatino and Organizing. Reading, MA: Addison...inputs required for an organization to perform its tasks ( Farace , Monge, and Russell, 1977). Information load is reflected in the amount of

  9. UTILITY ADVANCED TURBINE SYSTEMS (ATS) TECHNOLOGY READINESS TESTING: PHASE 3R

    Energy Technology Data Exchange (ETDEWEB)

    None

    1999-09-01

    The overall objective of the Advanced Turbine System (ATS) Phase 3 Cooperative Agreement between GE and the US Department of Energy (DOE) is the development of the GE 7H and 9H combined cycle power systems. The major effort will be expended on detail design. Validation of critical components and technologies will be performed, including: hot gas path component testing, sub-scale compressor testing, steam purity test trials, and rotational heat transfer confirmation testing. Processes will be developed to support the manufacture of the first system, which was to have been sited and operated in Phase 4 but will now be sited and operated commercially by GE. This change has resulted from DOE's request to GE for deletion of Phase 4 in favor of a restructured Phase 3 (as Phase 3R) to include full speed, no load (FSNL) testing of the 7H gas turbine. Technology enhancements that are not required for the first machine design but will be critical for future ATS advances in performance, reliability, and costs will be initiated. Long-term tests of materials to confirm design life predictions will continue. A schematic of the GE H machine is shown. This report summarizes work accomplished in 2Q99.

  10. Conformity of package inserts information to regulatory requirements among selected branded and generic medicinal products circulating on the East African market.

    Science.gov (United States)

    Sillo, Hiiti B; Masota, Nelson E; Kisoma, Sunday; Rago, Lembit; Mgoyela, Veronica; Kaale, Eliangiringa A

    2018-01-01

    Availability of correct and adequate information about medicines is an important aspect in ensuring rational use of medicines and hence facilitating safety and expected efficacy of medicines during therapy. Package inserts have proven to be a good source of information to the prescribers and patients whereby they have been useful in highlighting important information pertaining proper use and handling of the medicines. The present study was aimed at establishing the extent to which package inserts of medicines circulating on the markets of the East African Community (EAC) Partner States conform to medicines information requirements as established in the harmonized guidelines as well as national guidelines. A total of 99 package inserts from six (6) types of medicines namely Albendazole, Artemether/Lumefantrine (ALu), Ciprofloxacin, Paracetamol, Amoxicillin and Metronidazole were purposefully collected from three EAC Partner States: Kenya, Tanzania and Uganda. The medicines were selected based on their indications as first line treatments, high rates of utilization within the medicines supply system and their positions in treatment of diseases of public importance across EAC Partner States. The inserts were evaluated on the availability of information regarding fifteen (15) parameters as extracted from the EAC harmonized guidelines for registration of medicines. Moreover, comparisons were made between the percentage conformity of the branded versus generic products, markets from which the samples were collected, origin of the manufacturer and type of medicine. Majority (93.9-100%) of the medicines' package inserts highly conformed to the inclusion of the information regarding the description and composition of the medications, indications, dosage and methods of administration, warnings and precautions, contraindications and storage conditions. However, the information on handling and disposal, container package description, excipients used, clinical pharmacology of

  11. Studsvik`s fuel R and D projects

    Energy Technology Data Exchange (ETDEWEB)

    Grounes, M [Studsvik Nuclearr AB, Nykoping (Sweden)

    1997-08-01

    The report reviews some recently performed, ongoing and planned fuel R and D projects, executed by Studsvik Nuclear AB, a subsidiary of Studsvik AB. Data from these projects are used as experimental support for fuel modelling at high burnup. Much of Studsvik Nuclear`s R and D work has been concentrated on fuel testing, which can be made in the R2 test reactor with high precision under realistic water reactor conditions. This type of work started in the early 1960s. The fuel testing projects executed at Studsvik have been organized under three different types of sponsorship: International (multilateral) fuel projects: jointly sponsored internationally on a world-wide basis, with project information remaining restricted to the project participants throughout the project`s duration and for some pre-determined time after project completion; Bilateral fuel projects: sponsored by one single organization, or a few co-operating organizations, with project information remaining restricted to the sponsor, sometimes published later; in-house R and D work: sponsored by Studsvik Nuclear. The fuel testing activities can be divided into a number of well-defined steps as follows: Base irradiation, performed in a power reactor, or in Studsvik`s R2 test reactor; power ramping and/or other in-pile measurements, performed in Studsvik`s R2 test reactor. Non-destructive testing between different phases of an experiment, performed in Studsvik`s R2 reactor pool, or in Studsvik`s Hot Cell Laboratory; destructive post-irradiation examinations, performed in Studsvik`s Hot Cell Laboratory, or in the sponsor`s hot cell laboratory. 47 refs, 2 tabs.

  12. β-Arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration.

    Directory of Open Access Journals (Sweden)

    Elie Simard

    Full Text Available Over the last decade, it has been established that G-protein-coupled receptors (GPCRs signal not only through canonical G-protein-mediated mechanisms, but also through the ubiquitous cellular scaffolds β-arrestin-1 and β-arrestin-2. Previous studies have implicated β-arrestins as regulators of actin reorganization in response to GPCR stimulation while also being required for membrane protrusion events that accompany cellular motility. One of the most critical events in the active movement of cells is the cyclic phosphorylation and activation of myosin light chain (MLC, which is required for cellular contraction and movement. We have identified the myosin light chain phosphatase Targeting Subunit (MYPT-1 as a binding partner of the β-arrestins and found that β-arrestins play a role in regulating the turnover of phosphorylated myosin light chain. In response to stimulation of the angiotensin Type 1a Receptor (AT1aR, MLC phosphorylation is induced quickly and potently. We have found that β-arrestin-2 facilitates dephosphorylation of MLC, while, in a reciprocal fashion, β-arrestin 1 limits dephosphorylation of MLC. Intriguingly, loss of either β-arrestin-1 or 2 blocks phospho-MLC turnover and causes a decrease in the contraction of cells as monitored by atomic force microscopy (AFM. Furthermore, by employing the β-arrestin biased ligand [Sar(1,Ile(4,Ile(8]-Ang, we demonstrate that AT1aR-mediated cellular motility involves a β-arrestin dependent component. This suggests that the reciprocal regulation of MLC phosphorylation status by β-arrestins-1 and 2 causes turnover in the phosphorylation status of MLC that is required for cell contractility and subsequent chemotaxic motility.

  13. The Effects of information barrier requirements on the trilateral initiative attribute measurement system (AVNG)

    International Nuclear Information System (INIS)

    MacArthur, D.W.; Langner, D.C.; Whiteson, R.; Wolford, J.K.

    2001-01-01

    Although the detection techniques used for measuring classified materials are very similar to those used in unclassified measurements, the surrounding packaging is generally very different. If iZ classified item is to be measured, an information barrier is required to protect any classified data acquired. This information barrier must protect the classified information while giving the inspector confidence that the unclassified outputs accurately reflect the classified inputs, Both information barrier and authentication considerations must be considered during all phases of system design and fabrication. One example of such a measurement system is the attribute measurement system (termed the AVNG) designed for the: Trilateral Initiative. We will discuss the integration of information barrier components into this system as well as the effects of an information barrier (including authentication) concerns on the implementation of the detector systems.

  14. Third Congress on Information System Science and Technology

    Science.gov (United States)

    1968-04-01

    detecting information on the display scope. The user focuses an aiming circle (a ring of light) on information on the display scope and depresses a...themselves. Thus, the first step in uncovering the causes of lung cancer has been to establish the association of the incidence of that disease with...IN REQUIREMENTS —. /COST/EFFECTIVENESS K REVIEW Of DESIGN ALTERNATIVES I ! /CHANGED OPERATIONAL r ENVIRONMENT / mama ’ DETAILED DESIGN

  15. Information needs and requirements in patients with brain tumours and their relatives.

    Science.gov (United States)

    Reinert, Christiane; Rathberger, Katharina; Klinkhammer-Schalke, Monika; Kölbl, Oliver; Proescholdt, Martin; Riemenschneider, Markus J; Schuierer, Gerhard; Hutterer, Markus; Gerken, Michael; Hau, Peter

    2018-06-01

    Patients with brain tumours face a number of medical and social challenges. Previous studies have shown that these patients and their relatives need a high level of patient-oriented information and counselling. However, these needs are often underestimated. In this single-centre cross-sectional study, we evaluated, for the first time, the information needs of patients with brain tumours and their relatives depending on diagnosis, age and level of education. The participants were interviewed using pre-specified questionnaires. Answers were evaluated descriptively using standard statistical methods. A total of 888 questionnaires were sent out. The return rate was 50.7%. The majority of patients (nP = 103; 59.9%) and a higher proportion of relatives (nR = 103; 72.5%; p = 0.019) wished to receive a maximum of information. The majority (79.7% of patients; 83.1% of relatives) also stated that they preferred a personal, face-to-face meeting as primary source of information. The need for information increased with education (p = 0.015), and decreased with tumour grade (p = 0.025) and age (p = 0.118). Our data indicate that patients with brain tumours and their relatives have high information needs throughout their disease and continuously require information and counselling. Optimal provision of information is based on personal preferences, which needs to be evaluated appropriately. Patient-oriented information and counselling are parts of a successful communication strategy that can improve cancer care significantly.

  16. Detection of vehicle parts based on Faster R-CNN and relative position information

    Science.gov (United States)

    Zhang, Mingwen; Sang, Nong; Chen, Youbin; Gao, Changxin; Wang, Yongzhong

    2018-03-01

    Detection and recognition of vehicles are two essential tasks in intelligent transportation system (ITS). Currently, a prevalent method is to detect vehicle body, logo or license plate at first, and then recognize them. So the detection task is the most basic, but also the most important work. Besides the logo and license plate, some other parts, such as vehicle face, lamp, windshield and rearview mirror, are also key parts which can reflect the characteristics of vehicle and be used to improve the accuracy of recognition task. In this paper, the detection of vehicle parts is studied, and the work is novel. We choose Faster R-CNN as the basic algorithm, and take the local area of an image where vehicle body locates as input, then can get multiple bounding boxes with their own scores. If the box with maximum score is chosen as final result directly, it is often not the best one, especially for small objects. This paper presents a method which corrects original score with relative position information between two parts. Then we choose the box with maximum comprehensive score as the final result. Compared with original output strategy, the proposed method performs better.

  17. MORE: Management of Requirements in NPP Modernisation Projects, final report

    International Nuclear Information System (INIS)

    Fredriksen, R.; Katta, V.; Raspotnig, C.; Valkonen, J.

    2008-09-01

    This report documents the work and related activities of the MORE (Management of Requirements in NPP Modernisation Projects) (NKS-R project number NKS-R-2005-47) project. This report also provides a summary of the project activities and deliverables, and discusses possible application areas. The project has aimed at the industrial utilisation of the results from the TACO: (Traceability and Communication of Requirements in Digital I and C Systems Development) (NKS-R project number NKS-R-2002-16, completed June, 2005) project, and practical application of improved approaches and methods for requirements engineering and change management. Finally, the report provides a brief description of the extended industrial network and disseminations of the results in Nordic and NKS related events such as seminars and workshops. (au)

  18. MORE: Management of Requirements in NPP Modernisation Projects, final report

    Energy Technology Data Exchange (ETDEWEB)

    Fredriksen, R.; Katta, V.; Raspotnig, C. (Inst. for energiteknikk (IFE) (Norway)); Valkonen, J. (Technical Research Centre of Finland (VTT) (Finland))

    2008-09-15

    This report documents the work and related activities of the MORE (Management of Requirements in NPP Modernisation Projects) (NKS-R project number NKS-R-2005-47) project. This report also provides a summary of the project activities and deliverables, and discusses possible application areas. The project has aimed at the industrial utilisation of the results from the TACO: (Traceability and Communication of Requirements in Digital I and C Systems Development) (NKS-R project number NKS-R-2002-16, completed June, 2005) project, and practical application of improved approaches and methods for requirements engineering and change management. Finally, the report provides a brief description of the extended industrial network and disseminations of the results in Nordic and NKS related events such as seminars and workshops. (author)

  19. Taste information derived from T1R-expressing taste cells in mice.

    Science.gov (United States)

    Yoshida, Ryusuke; Ninomiya, Yuzo

    2016-03-01

    The taste system of animals is used to detect valuable nutrients and harmful compounds in foods. In humans and mice, sweet, bitter, salty, sour and umami tastes are considered the five basic taste qualities. Sweet and umami tastes are mediated by G-protein-coupled receptors, belonging to the T1R (taste receptor type 1) family. This family consists of three members (T1R1, T1R2 and T1R3). They function as sweet or umami taste receptors by forming heterodimeric complexes, T1R1+T1R3 (umami) or T1R2+T1R3 (sweet). Receptors for each of the basic tastes are thought to be expressed exclusively in taste bud cells. Sweet (T1R2+T1R3-expressing) taste cells were thought to be segregated from umami (T1R1+T1R3-expressing) taste cells in taste buds. However, recent studies have revealed that a significant portion of taste cells in mice expressed all T1R subunits and responded to both sweet and umami compounds. This suggests that sweet and umami taste cells may not be segregated. Mice are able to discriminate between sweet and umami tastes, and both tastes contribute to behavioural preferences for sweet or umami compounds. There is growing evidence that T1R3 is also involved in behavioural avoidance of calcium tastes in mice, which implies that there may be a further population of T1R-expressing taste cells that mediate aversion to calcium taste. Therefore the simple view of detection and segregation of sweet and umami tastes by T1R-expressing taste cells, in mice, is now open to re-examination. © 2016 Authors; published by Portland Press Limited.

  20. THE APPLICATION OF THE METHOD ENVIRONMENTAL VALUE AT RISK (EVaR IN ENVIRONMENTAL ECONOMY

    Directory of Open Access Journals (Sweden)

    Gabriela Cornelia I. PICIU

    2014-04-01

    Full Text Available Taking into account the fact that the methodology Value at Risk or the method VaR, which is omnipresent in investment banking and which has lately become a standard in the procedure of evaluating risks for any category of economic activities, we shall use a technique that is compatible with the VaR-market, called Environmental Value at Risk or EvaR. While the VaR- market uses a level of trust of 95%, the EvaR uses a set of levels up to 99,999%. Thus, we shall try to analyze the variables of the method EVaR, and the way in which this model can be applied as a risk of the lack (rarity of petroleum. This risk is not only analyzed as a unique risk of growing the prices, but also as an uncertainty risk on volatile markets, in which the price and the volatility are the main variables used by the function EVaR.

  1. Harmonizing routinely collected health information for strengthening quality management in health systems: requirements and practice.

    Science.gov (United States)

    Prodinger, Birgit; Tennant, Alan; Stucki, Gerold; Cieza, Alarcos; Üstün, Tevfik Bedirhan

    2016-10-01

    Our aim was to specify the requirements of an architecture to serve as the foundation for standardized reporting of health information and to provide an exemplary application of this architecture. The World Health Organization's International Classification of Functioning, Disability and Health (ICF) served as the conceptual framework. Methods to establish content comparability were the ICF Linking Rules. The Rasch measurement model, as a special case of additive conjoint measurement, which satisfies the required criteria for fundamental measurement, allowed for the development of a common metric foundation for measurement unit conversion. Secondary analysis of data from the North Yorkshire Survey was used to illustrate these methods. Patients completed three instruments and the items were linked to the ICF. The Rasch measurement model was applied, first to each scale, and then to items across scales which were linked to a common domain. Based on the linking of items to the ICF, the majority of items were grouped into two domains, Mobility and Self-care. Analysis of the individual scales and of items linked to a common domain across scales satisfied the requirements of the Rasch measurement model. The measurement unit conversion between items from the three instruments linked to the Mobility and Self-care domains, respectively, was demonstrated. The realization of an ICF-based architecture for information on patients' functioning enables harmonization of health information while allowing clinicians and researchers to continue using their existing instruments. This architecture will facilitate access to comprehensive and consistently reported health information to serve as the foundation for informed decision-making. © The Author(s) 2016.

  2. The educational needs of health information managers in an electronic environment: what information technology and health informatics skills and knowledge are required?

    Science.gov (United States)

    Robertson, Merryn; Callen, Joanne

    The profile of health information managers (HIMs) employed within one metropolitan area health service in New South Wales (NSW) was identified, together with which information technology and health informatics knowledge and skills they possess, and which ones they require in their workplace. The subjects worked in a variety of roles: 26% were employed in the area's Information Systems Division developing and implementing point-of-care clinical systems. Health information managers perceived they needed further continuing and formal education in point-of-care clinical systems, decision support systems, the electronic health record, privacy and security, health data collections, and database applications.

  3. Mapping of information and identification of construction waste at project life cycle

    Science.gov (United States)

    Wibowo, Mochamad Agung; Handayani, Naniek Utami; Nurdiana, Asri; Sholeh, Moh Nur; Pamungkas, Gita Silvia

    2018-03-01

    The development of construction project towards green construction is needed in order to improve the efficiency of construction projects. One that needs to be minimized is construction waste. Construction waste is waste generated from construction project activities, both solid waste and non solid waste. More specifically, the waste happens at every phase of the project life cycle. Project life cycle are the stage of idea, design, construction, and operation/maintenance. Each phase is managed by different stakeholders. Therefore it requires special handling from the involved stakeholders. The objective of the study is to map the information and identify the waste at each phase of the project life cycle. The purpose of mapping is to figure out the process of information and product flow and with its timeline. This mapping used Value Stream Mapping (VSM). Identification of waste was done by distributing questionnaire to respondents to know the waste according to owner, consultant planner, contractor, and supervisory consultant. The result of the study is the mapping of information flow and product flow at the phases of idea, design, construction, and operation/ maintenance.

  4. An evaluation of information sources and requirements for nuclear plant-aging research with life-extension implications

    International Nuclear Information System (INIS)

    Jacobs, P.T.

    1986-01-01

    Information requirements for plant-aging and life-extension research are discussed. Various information sources that have been used in plant-aging studies and reliability assessments are described. Data-base searches and analyses were performed for a specific system using several data bases and plant sources. Comments are provided on the results using the various information sources

  5. The R package EchoviewR for automated processing of active acoustic data using Echoview

    Directory of Open Access Journals (Sweden)

    Lisa-Marie Katarina Harrison

    2015-02-01

    Full Text Available Acoustic data is time consuming to process due to the large data size and the requirement to often undertake some data processing steps manually. Manual processing may introduce subjective, irreproducible decisions into the data processing work flow, reducing consistency in processing between surveys. We introduce the R package EchoviewR as an interface between R and Echoview, a commercially available acoustic processing software package. EchoviewR allows for automation of Echoview using scripting which can drastically reduce the manual work required when processing acoustic surveys. This package plays an important role in reducing subjectivity in acoustic data processing by allowing exactly the same process to be applied automatically to multiple surveys and documenting where subjective decisions have been made. Using data from a survey of Antarctic krill, we provide two examples of using EchoviewR: krill estimation and swarm detection.

  6. Investigation of miR-1202, miR-135a, and miR-16 in Major Depressive Disorder and Antidepressant Response.

    Science.gov (United States)

    Fiori, Laura M; Lopez, Juan Pablo; Richard-Devantoy, Stéphane; Berlim, Marcelo; Chachamovich, Eduardo; Jollant, Fabrice; Foster, Jane; Rotzinger, Susan; Kennedy, Sidney H; Turecki, Gustavo

    2017-08-01

    Major depressive disorder is a debilitating illness, which is most commonly treated with antidepressant drugs. As the majority of patients do not respond on their first trial, there is great interest in identifying biological factors that indicate the most appropriate treatment for each patient. Studies suggest that microRNA represent excellent biomarkers to predict antidepressant response. We investigated the expression of miR-1202, miR-135a, and miR-16 in peripheral blood from 2 cohorts of depressed patients who received 8 weeks of antidepressant therapy. Expression was quantified at baseline and after treatment, and its relationship to treatment response and depressive symptoms was assessed. In both cohorts, responders displayed lower baseline miR-1202 levels compared with nonresponders, which increased following treatment. Ultimately, our results support the involvement of microRNA in antidepressant response and suggest that quantification of their levels in peripheral samples represents a valid approach to informing treatment decisions. © The Author 2017. Published by Oxford University Press on behalf of CINP.

  7. Modelling health care processes for eliciting user requirements: a way to link a quality paradigm and clinical information system design.

    Science.gov (United States)

    Staccini, P; Joubert, M; Quaranta, J F; Fieschi, D; Fieschi, M

    2001-12-01

    Healthcare institutions are looking at ways to increase their efficiency by reducing costs while providing care services with a high level of safety. Thus, hospital information systems have to support quality improvement objectives. The elicitation of the requirements has to meet users' needs in relation to both the quality (efficacy, safety) and the monitoring of all health care activities (traceability). Information analysts need methods to conceptualise clinical information systems that provide actors with individual benefits and guide behavioural changes. A methodology is proposed to elicit and structure users' requirements using a process-oriented analysis, and it is applied to the blood transfusion process. An object-oriented data model of a process has been defined in order to organise the data dictionary. Although some aspects of activity, such as 'where', 'what else', and 'why' are poorly represented by the data model alone, this method of requirement elicitation fits the dynamic of data input for the process to be traced. A hierarchical representation of hospital activities has to be found for the processes to be interrelated, and for their characteristics to be shared, in order to avoid data redundancy and to fit the gathering of data with the provision of care.

  8. Experimental investigations on automobile air conditioners working with R134a and R290/R600a as an alternative

    Directory of Open Access Journals (Sweden)

    Kandhaswamy Karthikeyan

    2017-01-01

    Full Text Available In this work, the performance of R134a based automobile air conditioning system has been evaluated by retrofitted with R290/R600a mixture (in the ratio of 50:50, by mass, as an alternative. The performance was evaluated at five different operating speeds (1000, 1500, 2000, 2500, and 3000, which covers the entire range of working conditions with four different cabin load (100, 200, 300, and 400 W. The condenser inlet air temperature was varied in the range between 30 and 50°C, which covers the entire climatic variations in Coimbatore city of India. The performance characteristics such as, refrigerating effect, coefficient of performance, compressor power consumption, and compressor discharge temperatures were considered for comparison. The results showed that, hydrocarbon mixture has faster cooling rate due to its high latent heat of vaporization, 5% higher coefficient of performance due to higher refrigeration effect, 8-10 K lower compressor discharge temperature due to its lower specific heat ratio with 5% lower compressor power consumption due to its lower viscosity and lower liquid density. The charge requirement of R290/R600a mixture is about 50% less compared to R134a. However, the mixture composition is considered as an interment replacement in automobile air conditioners due to composition shift under leak-age conditions. Hence, R290/R600a mixture is considered as an interim energy efficient and environment friendly option in R134a automobile air conditioners to extend its life.

  9. Consumer attitudes toward information displayed at food buffets in commercial restaurants

    Directory of Open Access Journals (Sweden)

    Tatiana Barbieri

    2012-12-01

    Full Text Available This study aimed to evaluate the attitude of consumers towards information about dishes in a commercial restaurant. This research was conducted from January to April 2009 in a restaurant in the city of Santa Maria (RS, Brazil. Food information including the name of the dish, ingredients, health benefits and warnings, and calorie value was displayed. After providing this nutritional information, a questionnaire was applied to 300 consumers at the restaurant to observe their attitudes towards the food information. It was found that 10.57% of the respondents reported allergy or intolerance to some kinds of food and that 10.98% of the respondents reported having diseases that require moderate consumption and/or total restriction on the consumption of those foods. However, 84.96% of the respondents did not restrict consumption of any food, even though those foods may have posed a risk to their health, and 58.54% of the respondents consumed some food due to the potential benefits to their health. With regard to the respondents' level of satisfaction concerning the food information provided, 72.76% considered the information provided as very good. The respondents had a tendency to change their behavior towards consumption after having access to information about the dishes displayed.

  10. Beginning Data Science in R

    DEFF Research Database (Denmark)

    Mailund, Thomas

    in R details how data science is a combination of statistics, computational science, and machine learning. You’ll see how to efficiently structure and mine data to extract useful patterns and build mathematical models. This requires computational methods and programming, and R is an ideal programming...... language for this. This book is based on a number of lecture notes for classes the author has taught on data science and statistical programming using the R programming language. Modern data analysis requires computational skills and usually a minimum of programming. You will: Perform data science...... and analytics using statistics and the R programming language Visualize and explore data, including working with large data sets found in big data Build an R package Test and check your code Practice version control Profile and optimize your code...

  11. Quantifying cardinal temperatures and thermal time required for germination of Silybum marianum seed

    Directory of Open Access Journals (Sweden)

    Ghasem Parmoon

    2015-04-01

    Full Text Available The response of seed germination to environmental factors can be estimated by nonlinear regression. The present study was performed to compare four nonlinear regression models (segmented, beta, beta modified, and dent-like to describe the germination rate–temperature relationships of milk thistle (Silybum marianum L. at six constant temperatures, with the aim of identifying the cardinal temperatures and thermal times required to reach different germination percentiles. Models and statistical indices were calibrated using an iterative optimization method and their performance was compared by root mean square error (RMSE, coefficient of determination (R2 and Akaike information criterion correction (AICc. The beta model was found to be the best model for predicting the required time to reach 50% germination (D50, (R2 = 0.99; RMSE = 0.004; AICc = − 276.97. Based on the model outputs, the base, optimum, and maximum temperatures of seed germination were 5.19 ± 0.79, 24.01 ± 0.11, and 34.32 ± 0.36 °C, respectively. The thermal times required for 50% and 90% germination were 4.99 and 7.38 degree-days, respectively.

  12. Using and Disclosing Confidential Patient Information and The English Common Law: What are the Information Requirements of a Valid Consent?

    Science.gov (United States)

    Chico, Victoria; Taylor, Mark J

    2018-02-01

    The National Health Service in England and Wales is dependent upon the flow of confidential patient data. In the context of consent to the use of patient health data, insistence on the requirements of an 'informed' consent that are difficult to achieve will drive reliance on alternatives to consent. Here we argue that one can obtain a valid consent to the disclosure of confidential patient data, such that this disclosure would not amount to a breach of the common law duty of confidentiality, having provided less information than would typically be associated with an 'informed consent'. This position protects consent as a practicable legal basis for disclosure from debilitating uncertainty or impracticability and, perhaps counter-intuitively, promotes patient autonomy.

  13. [Subjective Level of Information and Information Needs of Patients with an Approved Rehabilitation Application and Patients at the End of Rehabilitation Results of a Written Survey].

    Science.gov (United States)

    Walther, Anna Lena; Schreiber, Dora; Falk, Johannes; Deck, Ruth

    2017-08-01

    Aim The aim of the study was to identify the subjective level of information and information needs of patients with an approved rehabilitation application and patients at the end of rehabilitation with regard to preferred subjects and kind of information transfer. Method Written survey with N=283 patients with approved rehabilitation application and N=388 patients at the end of rehabilitation. Results Both groups reported high information needs particularly regarding treatments during rehabilitation, rehabilitation aftercare and rehabilitation aims. A conversation with their physician, a brochure and a website are the preferred information pathways. Conclusion Taking into account the topics for which both groups require information and the preference regarding the kind of information transfer can make a valuable contribution for the development of needs-oriented information material. © Georg Thieme Verlag KG Stuttgart · New York.

  14. SAVANNAH RIVER SITE R REACTOR DISASSEMBLY BASIN IN SITU DECOMMISSIONING

    Energy Technology Data Exchange (ETDEWEB)

    Langton, C.; Blankenship, J.; Griffin, W.; Serrato, M.

    2009-12-03

    The US DOE concept for facility in-situ decommissioning (ISD) is to physically stabilize and isolate in tact, structurally sound facilities that are no longer needed for their original purpose of, i.e., generating (reactor facilities), processing(isotope separation facilities) or storing radioactive materials. The 105-R Disassembly Basin is the first SRS reactor facility to undergo the in-situ decommissioning (ISD) process. This ISD process complies with the105-R Disassembly Basin project strategy as outlined in the Engineering Evaluation/Cost Analysis for the Grouting of the R-Reactor Disassembly Basin at the Savannah River Site and includes: (1) Managing residual water by solidification in-place or evaporation at another facility; (2) Filling the below grade portion of the basin with cementitious materials to physically stabilize the basin and prevent collapse of the final cap - Sludge and debris in the bottom few feet of the basin will be encapsulated between the basin floor and overlying fill material to isolate if from the environment; (3) Demolishing the above grade portion of the structure and relocating the resulting debris to another location or disposing of the debris in-place; and (4) Capping the basin area with a concrete slab which is part of an engineered cap to prevent inadvertent intrusion. The estimated total grout volume to fill the 105-R Reactor Disassembly Basin is 24,424 cubic meters or 31,945 cubic yards. Portland cement-based structural fill materials were design and tested for the reactor ISD project and a placement strategy for stabilizing the basin was developed. Based on structural engineering analyses and work flow considerations, the recommended maximum lift height is 5 feet with 24 hours between lifts. Pertinent data and information related to the SRS 105-R-Reactor Disassembly Basin in-situ decommissioning include: regulatory documentation, residual water management, area preparation activities, technology needs, fill material designs

  15. An open, component-based information infrastructure for integrated health information networks.

    Science.gov (United States)

    Tsiknakis, Manolis; Katehakis, Dimitrios G; Orphanoudakis, Stelios C

    2002-12-18

    A fundamental requirement for achieving continuity of care is the seamless sharing of multimedia clinical information. Different technological approaches can be adopted for enabling the communication and sharing of health record segments. In the context of the emerging global information society, the creation of and access to the integrated electronic health record (I-EHR) of a citizen has been assigned high priority in many countries. This requirement is complementary to an overall requirement for the creation of a health information infrastructure (HII) to support the provision of a variety of health telematics and e-health services. In developing a regional or national HII, the components or building blocks that make up the overall information system ought to be defined and an appropriate component architecture specified. This paper discusses current international priorities and trends in developing the HII. It presents technological challenges and alternative approaches towards the creation of an I-EHR, being the aggregation of health data created during all interactions of an individual with the healthcare system. It also presents results from an ongoing Research and Development (R&D) effort towards the implementation of the HII in HYGEIAnet, the regional health information network of Crete, Greece, using a component-based software engineering approach. Critical design decisions and related trade-offs, involved in the process of component specification and development, are also discussed and the current state of development of an I-EHR service is presented. Finally, Human Computer Interaction (HCI) and security issues, which are important for the deployment and use of any I-EHR service, are considered.

  16. r det er svært at være ung i DK

    DEFF Research Database (Denmark)

    Nielsen, Jens Christian; Sørensen, Niels Ulrik; Grubb, Ane

    I rapporten Når det er svært at være ung i DK – unges beretninger om mistrivsel og ungdomsliv præsenteres resultaterne af et kvalitativt studie af mistrivsel og ungdomsliv blandt 15-24-årige unge i Danmark. Studiet bygger på dybdegående interviews med 33 unge fra forskellige dele af landet, der...... fortæller om deres erfaringer med diverse mistrivselsformer, som ensomhed, selvskadende adfærd og mobning, og om deres besvær med at håndtere de krav, udfordringer og muligheder, der i øvrigt præger det moderne ungdomsliv. Studiet indgår i det treårige forskningsprojekt Når det er svært at være ung i DK...

  17. FEDERAL RULEMAKING: Procedural and Analytical Requirements at OSHA and Other Agencies

    Science.gov (United States)

    2001-06-14

    informal rulemaking. Formal rulemaking is used in ratemaking proceedings and in certain other cases when rules are required by statute to be made “on...substantial flexibility regarding how the analyses should be prepared, but also indicates that the analyses should contain certain basic elements and...calendar days, so our review is limited to a description of the issuing agency’s rulemaking actions.25 We also collect basic information about the nonmajor

  18. Irradiation experience of IPEN fuel at IEA-R1 research reactor

    International Nuclear Information System (INIS)

    Perrotta, Jose A.; Neto, Adolfo; Durazzo, Michelangelo; Souza, Jose A.B. de; Frajndlich, Roberto

    1998-01-01

    IPEN/CNEN-SP produces, for its IEA-R1 Research Reactor, MTR fuel assemblies based on U 3 O 8 -Al dispersion fuel type. Since 1985 a qualification program on these fuel assemblies has been performed. Average 235 U burnup of 30% and peak burnup of 50% was already achieved by these fuel assemblies. This paper presents some results acquire, by these fuel assemblies, under irradiation at IEA-R1 Research Reactor. (author)

  19. Peer-Reviewed Research and the IEP: Implications of "Ridley School District v. M.R. and J.R. ex rel. E.R." (2012)

    Science.gov (United States)

    Yell, Mitchell L.; Katsiyannis, Antonis; Losinski, Mickey; Marshall, Kelsey

    2016-01-01

    This article examines a case out of the U.S. Court of Appeals for the Third Circuit: "Ridley School District v. M.R and J.R. ex rel. E.R." (2012). The case is the first circuit court case in which the Individuals with Disabilities Education Improvement Act requirement that special education services be based on peer-reviewed research…

  20. Regulatory quality assurance requirements for the operation of nuclear R and D facilities in Korea

    International Nuclear Information System (INIS)

    Kwon, H.I.; Lim, N.J.

    2006-01-01

    Full text: Korea Atomic Energy Research Institute (KAERI) has many R and D facilities in operation. including HANARO research reactor, radioactive waste treatment facility (RWTF), post-irradiation examination facility (PIEF) and irradiated material test facility (IMEF). Recently. nation-wide interest is focused on the safety and security of major industrial facilities. Safe operation of nuclear facilities is imperative because of the consequence of public disaster by radiological release/contamination, in case of an accident. Recently, Ministry of Science and Technology (MOST) of the Korean government announced amendments of Atomic Energy laws to enforce requirements of the physical protection and radiological emergency. All provisions on nuclear safety regulation and radiation protection are entrusted to the Atomic Energy Act(AEA). The Act is enacted as the main law concerning the safety regulation of nuclear installations, and is supplemented by the Enforcement Decree and Enforcement Regulation of the Act. These Atomic Energy laws include provisions on the construction permission and the operation license of nuclear installations, such as nuclear power reactors, research reactors, nuclear ships, nuclear fuel fabrication facilities, spent fuel treatment facilities, etc. Regulatory requirements for the regulatory inspection and the safety measures for operation are also defined in the laws. The Notice of the MOST prescribes specific issues including regulatory requirements and technical standards, as entrusted by the AEA, the Decree and the Regulation. Detailed QA requirements for nuclear installations are specified differently, depending upon the type of facility. The guidelines for safety reviews and regulatory inspections are developed by the Korea Institute of Nuclear Safety (KINS), which is an exclusive organization for safety regulation of nuclear installations in Korea. In this paper, the context of the Atomic Energy laws were reviewed to confirm the

  1. Ihh and PTH1R signaling in limb mesenchyme is required for proper segmentation and subsequent formation and growth of digit bones.

    Science.gov (United States)

    Amano, Katsuhiko; Densmore, Michael; Fan, Yi; Lanske, Beate

    2016-02-01

    Digit formation is a process, which requires the proper segmentation, formation and growth of phalangeal bones and is precisely regulated by several important factors. One such factor is Ihh, a gene linked to BDA1 and distal symphalangism in humans. In existing mouse models, mutations in Ihh have been shown to cause multiple synostosis in the digits but lead to perinatal lethality. To better study the exact biological and pathological events which occur in these fused digits, we used a more viable Prx1-Cre;Ihh(fl/fl) model in which Cre recombinase is expressed during mesenchymal condensation in the earliest limb buds at E9.5 dpc and found that mutant digits continuously fuse postnatally until phalanges are finally replaced by an unsegmented "one-stick bone". Mutant mice displayed osteocalcin-positive mature osteoblasts, but had reduced proliferation and abnormal osteogenesis. Because of the close interaction between Ihh and PTHrP during endochondral ossification, we also examined the digits of Prx1-Cre;PTH1R(fl/fl) mice, where the receptor for PTHrP was conditionally deleted. Surprisingly, we found PTH1R deletion caused symphalangism, demonstrating another novel function of PTH1R signaling in digit formation. We characterized the symphalangism process whereby initial cartilaginous fusion prevented epiphyseal growth plate formation, resulting in resorption and replacement of the remaining cartilage by bony tissue. Chondrocyte differentiation displayed abnormal directionality in both mutants. Lastly, Prx1-Cre;Ihh(fl/fl);Jansen Tg mice, in which a constitutively active PTH1R allele was introduced into Ihh mutants, were established to address the possible involvement of PTH1R signaling in Ihh mutant digits. These rescue mice failed to show significantly improved phenotype, suggesting that PTH1R signaling in chondrocytes is not sufficient to restore digit formation. Our results demonstrate that Ihh and PTH1R signaling in limb mesenchyme are both essential to regulate

  2. The FRJ 1 reactor (MERLIN) at Juelich, F.R. Germany and associated hot cell facilities. Information sheets

    International Nuclear Information System (INIS)

    Hardt, P. von der; Roettger, H.

    1981-01-01

    Technical information is given on the FRJ 1 reactor and associated hot cell facilities, with the main emphasis on experimental irradiation facilities, specialized irradiation devices (loops and capsules) and possibilities for post-irradiation examinations of samples. The information is presented in the form of eight information sheets under the headings: main characteristics of the reactor; utilization and specialization of the reactor; experimental facilities; neutron spectra; main characteristics of specialized irradiation devices; main characteristics of hot cell facilities; equipment and techniques available for post-irradiation examinations; utilization and specialization of the hot cell facilities

  3. 76 FR 23615 - Notice of Submission of Proposed Information Collection to OMB; Quality Control Requirements for...

    Science.gov (United States)

    2011-04-27

    ... Proposed Information Collection to OMB; Quality Control Requirements for Direct Endorsement Lenders AGENCY... proposal. This information is collected from Direct Endorsement lenders in order to meet FHA's quality... Lenders. OMB Approval Number: 2502-Pending. Form Numbers: None. Description of the Need for the...

  4. Yeast polypeptide exit tunnel ribosomal proteins L17, L35 and L37 are necessary to recruit late-assembling factors required for 27SB pre-rRNA processing.

    Science.gov (United States)

    Gamalinda, Michael; Jakovljevic, Jelena; Babiano, Reyes; Talkish, Jason; de la Cruz, Jesús; Woolford, John L

    2013-02-01

    Ribosome synthesis involves the coordinated folding and processing of pre-rRNAs with assembly of ribosomal proteins. In eukaryotes, these events are facilitated by trans-acting factors that propel ribosome maturation from the nucleolus to the cytoplasm. However, there is a gap in understanding how ribosomal proteins configure pre-ribosomes in vivo to enable processing to occur. Here, we have examined the role of adjacent yeast r-proteins L17, L35 and L37 in folding and processing of pre-rRNAs, and binding of other proteins within assembling ribosomes. These three essential ribosomal proteins, which surround the polypeptide exit tunnel, are required for 60S subunit formation as a consequence of their role in removal of the ITS2 spacer from 27SB pre-rRNA. L17-, L35- and L37-depleted cells exhibit turnover of aberrant pre-60S assembly intermediates. Although the structure of ITS2 does not appear to be grossly affected in their absence, these three ribosomal proteins are necessary for efficient recruitment of factors required for 27SB pre-rRNA processing, namely, Nsa2 and Nog2, which associate with pre-60S ribosomal particles containing 27SB pre-rRNAs. Altogether, these data support that L17, L35 and L37 are specifically required for a recruiting step immediately preceding removal of ITS2.

  5. rTMS neuromodulation improves electrocortical functional measures of information processing and behavioral responses in autism

    Directory of Open Access Journals (Sweden)

    Estate M Sokhadze

    2014-08-01

    Full Text Available Objectives: Reports in autism spectrum disorders (ASD of a minicolumnopathy with consequent deficits of lateral inhibition help explain observed behavioral and executive dysfunctions. We propose that neuromodulation based on rTMS will enhance lateral inhibition through activation of inhibitory double bouquet interneurons and will be accompanied by improvements in the prefrontal executive functions. Methods: The current study used ERPs in a visual oddball task with illusory figures. We compared clinical, behavioral and electrocortical outcomes in 2 groups of children with autism (TMS, wait-list group [WTL]. We predicted that 18 session long course in autistic patients will have better behavioral and ERP outcomes as compared to age- and IQ-matched wait-list group. We used 18 sessions of 1Hz rTMS applied over the dorso-lateral prefrontal cortex in 27 individuals with ASD diagnosis. The WTL group was comprised of 27 age-matched ASD subjects. Results: Post-TMS evaluations showed decreased irritability and hyperactivity and decreased stereotypic behaviors. Following rTMS we found decreased amplitude and prolonged latency in the fronto-central ERPs to non-targets in the TMS group. These ERP changes along with increased centro-parietal ERPs to targets are indicative of more efficient processing of information post-TMS. Another finding was increased magnitude of error-related negativity (ERN during commission errors. We calculated normative post-error reaction time (RT slowing response in both groups and found that rTMS was accompanied by post-error RT slowing and higher accuracy of responses, whereas the WTL group kept on showing typical for ASD post-error RT speeding and had higher error rate. Conclusion: Results from our study indicate that rTMS improves executive functioning in ASD as evidenced by normalization of ERP responses and behavioral reactions during executive function test, and also by improvements in clinical behavioral evaluations.

  6. ACT-R Electronic Bookshelf: An Adaptive System To Support Learning ACT-R on the Web.

    Science.gov (United States)

    Brusilovsky, Peter; Anderson, John

    This paper describes the electronic ACT-R Bookshelf, a system which supports learning ACT-R, a well-known theory in the field of cognitive psychology, over the World Wide Web. ACT-R Bookshelf is a collection of electronic books on various aspects of ACT-R. The primary role of ACT-R Bookshelf is to serve as a 24-hour information resource for…

  7. Searches at HERA for Squarks in R-Parity Violating Supersymmetry

    CERN Document Server

    Adloff, C.; Andrieu, B.; Anthonis, T.; Arkadov, V.; Astvatsatourov, A.; Ayyaz, I.; Babaev, A.; Bahr, J.; Baranov, P.; Barrelet, E.; Bartel, W.; Bassler, U.; Bate, P.; Beglarian, A.; Behnke, O.; Beier, C.; Belousov, A.; Benisch, T.; Berger, Christoph; Bernardi, G.; Berndt, T.; Bizot, J.C.; Boudry, V.; Braunschweig, W.; Brisson, V.; Broker, H.B.; Brown, D.P.; Bruckner, W.; Bruel, P.; Bruncko, D.; Burger, J.; Busser, F.W.; Bunyatyan, A.; Burkhardt, H.; Burrage, A.; Buschhorn, G.; Campbell, A.J.; Cao, Jun; Carli, T.; Caron, S.; Clarke, D.; Clerbaux, B.; Collard, C.; Contreras, J.G.; Coppens, Y.R.; Coughlan, J.A.; Cousinou, M.C.; Cox, B.E.; Cozzika, G.; Cvach, J.; Dainton, J.B.; Dau, W.D.; Daum, K.; Davidsson, M.; Delcourt, B.; Delerue, N.; Demirchyan, R.; De Roeck, A.; De Wolf, E.A.; Diaconu, C.; Dingfelder, J.; Dixon, P.; Dodonov, V.; Dowell, J.D.; Droutskoi, A.; Dubak, A.; Duprel, C.; Eckerlin, Guenter; Eckstein, D.; Efremenko, V.; Egli, S.; Eichler, R.; Eisele, F.; Eisenhandler, E.; Ellerbrock, M.; Elsen, E.; Erdmann, M.; Erdmann, W.; Faulkner, P.J.W.; Favart, L.; Fedotov, A.; Felst, R.; Ferencei, J.; Ferron, S.; Fleischer, M.; Fleming, Y.H.; Flugge, G.; Fomenko, A.; Foresti, I.; Formanek, J.; Foster, J.M.; Franke, G.; Gabathuler, E.; Gabathuler, K.; Garvey, J.; Gassner, J.; Gayler, Joerg; Gerhards, R.; Gerlich, C.; Ghazarian, S.; Goerlich, L.; Gogitidze, N.; Goldberg, M.; Goodwin, C.; Grab, C.; Grassler, H.; Greenshaw, T.; Grindhammer, Guenter; Hadig, T.; Haidt, D.; Hajduk, L.; Haynes, W.J.; Heinemann, B.; Heinzelmann, G.; Henderson, R.C.W.; Hengstmann, S.; Henschel, H.; Heremans, R.; Herrera, G.; Herynek, I.; Hildebrandt, M.; Hilgers, M.; Hiller, K.H.; Hladky, J.; Hoting, P.; Hoffmann, D.; Horisberger, R.; Hurling, S.; Ibbotson, M.; Issever, C.; Jacquet, M.; Jaffre, M.; Janauschek, L.; Jansen, D.M.; Janssen, X.; Jemanov, V.; Jonsson, L.; Johnson, D.P.; Jones, M.A.S.; Jung, H.; Kastli, H.K.; Kant, D.; Kapichine, M.; Karlsson, M.; Karschnick, O.; Keil, F.; Keller, N.; Kennedy, J.; Kenyon, I.R.; Kermiche, S.; Kiesling, Christian M.; Kjellberg, P.; Klein, M.; Kleinwort, C.; Knies, G.; Koblitz, B.; Kolya, S.D.; Korbel, V.; Kostka, P.; Kotelnikov, S.K.; Koutouev, R.; Koutov, A.; Krehbiel, H.; Kroseberg, J.; Kruger, K.; Kupper, A.; Kuhr, T.; Kurca, T.; Lahmann, R.; Lamb, D.; Landon, M.P.J.; Lange, W.; Lastovicka, T.; Laycock, P.; Lebailly, E.; Lebedev, A.; Leissner, B.; Lemrani, R.; Lendermann, V.; Levonian, S.; Lindstroem, M.; List, B.; Lobodzinska, E.; Lobodzinski, B.; Loginov, A.; Loktionova, N.; Lubimov, V.; Luders, S.; Luke, D.; Lytkin, L.; Magnussen, N.; Mahlke-Kruger, H.; Malden, N.; Malinovski, E.; Malinovski, I.; Maracek, R.; Marage, P.; Marks, J.; Marshall, R.; Martyn, H.U.; Martyniak, J.; Maxfield, S.J.; Meer, D.; Mehta, A.; Meier, K.; Merkel, P.; Meyer, A.B.; Meyer, H.; Meyer, J.; Meyer, P.O.; Mikocki, S.; Milstead, D.; Mkrtchian, T.; Mohr, R.; Mohrdieck, S.; Mondragon, M.N.; Moreau, F.; Morozov, A.; Morris, J.V.; Muller, K.; Murin, P.; Nagovizin, V.; Naroska, B.; Naumann, J.; Naumann, T.; Nellen, G.; Newman, Paul R.; Nicholls, T.C.; Niebergall, F.; Niebuhr, C.; Nix, O.; Nowak, G.; Nunnemann, T.; Olsson, J.E.; Ozerov, D.; Panassik, V.; Pascaud, C.; Patel, G.D.; Peez, M.; Perez, E.; Phillips, J.P.; Pitzl, D.; Poschl, R.; Potachnikova, I.; Povh, B.; Rabbertz, K.; Radel, G.; Rauschenberger, J.; Reimer, P.; Reisert, B.; Reyna, D.; Riess, S.; Risler, C.; Rizvi, E.; Robmann, P.; Roosen, R.; Rostovtsev, A.; Royon, C.; Rusakov, S.; Rybicki, K.; Sankey, D.P.C.; Scheins, J.; Schilling, F.P.; Schleper, P.; Schmidt, D.; Schmitt, S.; Schneider, M.; Schoeffel, L.; Schoning, A.; Schorner, T.; Schroder, V.; Schultz-Coulon, H.C.; Schwanenberger, C.; Sedlak, K.; Sefkow, F.; Chekelian, V.I.; Sheviakov, I.; Shtarkov, L.N.; Sirois, Y.; Sloan, T.; Smirnov, P.; Solochenko, V.; Solovev, Y.; Spaskov, V.; Specka, Arnd E.; Spitzer, H.; Stamen, R.; Steinhart, J.; Stella, B.; Stellberger, A.; Stiewe, J.; Straumann, U.; Struczinski, W.; Swart, M.; Tasevsky, M.; Chernyshov, V.; Chetchelnitski, S.; Thompson, Graham; Thompson, P.D.; Tobien, N.; Traynor, D.; Truoel, Peter; Tsipolitis, G.; Tsurin, I.; Turnau, J.; Turney, J.E.; Tzamariudaki, E.; Udluft, S.; Usik, A.; Valkar, S.; Valkarova, A.; Vallee, C.; Van Mechelen, P.; Vassilev, S.; Vazdik, Y.; Vichnevski, A.; Wacker, K.; Wallny, R.; Walter, T.; Waugh, B.; Weber, G.; Weber, M.; Wegener, D.; Werner, M.; Werner, N.; White, G.; Wiesand, S.; Wilksen, T.; Winde, M.; Winter, G.G.; Wissing, C.; Wobisch, M.; Wollatz, H.; Wunsch, E.; Wyatt, A.C.; Zacek, J.; Zalesak, J.; Zhang, Z.; Zhokin, A.; Zomer, F.; Zsembery, J.; zur Nedden, M.

    2001-01-01

    A search for squarks in R-parity violating supersymmetry is performed in e^+p collisions at HERA at a centre of mass energy of 300 GeV, using H1 data corresponding to an integrated luminosity of 37 pb^(-1). The direct production of single squarks of any generation in positron-quark fusion via a Yukawa coupling lambda' is considered, taking into account R-parity violating and conserving decays of the squarks. No significant deviation from the Standard Model expectation is found. The results are interpreted in terms of constraints within the Minimal Supersymmetric Standard Model (MSSM), the constrained MSSM and the minimal Supergravity model, and their sensitivity to the model parameters is studied in detail. For a Yukawa coupling of electromagnetic strength, squark masses below 260 GeV are excluded at 95% confidence level in a large part of the parameter space. For a 100 times smaller coupling strength masses up to 182 GeV are excluded.

  8. Managing technology licensing for stochastic R&D: from the perspective of an enterprise information system

    Science.gov (United States)

    Hong, Xianpei; Zhao, Dan; Wang, Zongjun

    2016-10-01

    Enterprise information technology (IT) plays an important role in technology innovation management for high-tech enterprises. However, to date most studies on enterprise technology innovation have assumed that the research and development (R&D) outcome is certain. This assumption does not always hold in practice. Motivated by the current practice of some IT industries, we establish a three-stage duopoly game model, including the R&D stage, the licensing stage and the output stage, to investigate the influence of bargaining power and technology spillover on the optimal licensing policy for the innovating enterprise when the outcome of R&D is uncertain. Our results demonstrate that (1) if the licensor has low (high) bargaining power, fixed-fee (royalty) licensing is always superior to royalty (fixed-fee) licensing to the licensor regardless of technology spillover; (2) if the licensor has moderate bargaining power and technology spillover is low (high) as well, fixed-fee (royalty) licensing is superior to royalty (fixed-fee) licensing; (3) under two-part tariff licensing and the assumption of licensors with full bargaining power, if a negative prepaid fixed fee is not allowed, two-part tariff licensing is equivalent to royalty licensing which is the optimal licensing policy; if negative prepaid fixed fee is allowed, the optimal policy is two-part tariff licensing.

  9. The optimum operating conditions of the phased double-rotor facility at the et-R R-1 reactor. Vol. 2

    Energy Technology Data Exchange (ETDEWEB)

    Naguib, K; Habib, N; Kilany, M; Adib, M [Reactor and Neutron Physics Department, Nuclear Research Center, AEA., Cairo (Egypt); Wahba, M [Dept. of Engineering Physics and Mathematics, Faculty of Engineering, Ain Shams University, Cairo (Egypt)

    1996-03-01

    The pulsed neutron polyenergetic thermal beam at ET-R R-1 is produced by a phased double-rotor facility. One of the rotors has two diametrically opposite curved slots, while the second is designed to operate as a rotating collimator, the dimensions of the phased rotating collimator are selected to match the curved slot rotor. The calculated collimator transmissions at different operating conditions are found to be in good agreement with the experimental ones. The optimum operating conditions of double-rotor facility are deduced. The calculations were carried out using a computer programme RCOL. The RCOL was designed in Fortran-77 to operate on PCs. 6 figs.

  10. The optimum operating conditions of the phased double-rotor facility at the et-R R-1 reactor. Vol. 2

    International Nuclear Information System (INIS)

    Naguib, K.; Habib, N.; Kilany, M.; Adib, M.; Wahba, M.

    1996-01-01

    The pulsed neutron polyenergetic thermal beam at ET-R R-1 is produced by a phased double-rotor facility. One of the rotors has two diametrically opposite curved slots, while the second is designed to operate as a rotating collimator, the dimensions of the phased rotating collimator are selected to match the curved slot rotor. The calculated collimator transmissions at different operating conditions are found to be in good agreement with the experimental ones. The optimum operating conditions of double-rotor facility are deduced. The calculations were carried out using a computer programme RCOL. The RCOL was designed in Fortran-77 to operate on PCs. 6 figs

  11. R&D for a Soft X-Ray Free Electron Laser Facility

    Energy Technology Data Exchange (ETDEWEB)

    Corlett, John; Attwood, David; Byrd, John; Denes, Peter; Falcone, Roger; Heimann, Phil; Leemans, Wim; Padmore, Howard; Prestemon, Soren; Sannibale, Fernando; Schlueter, Ross; Schroeder, Carl; Staples, John; Venturini, Marco; Warwick, Tony; Wells, Russell; Wilcox, Russell; Zholent, Alexander; Adolphsen, Chris; Arthur, John; Bergmann, Uwe; Cai, Yunhai; Colby, Eric; Dowell, David; Emma, Paul; Fox, John; Frisch, Josef; Galayda, John; Hettel, Robert; Huang, Zhirong; Phinney, Nan; Rabedeau, Tom; Raubenheimer, Tor; Reis, David; Schmerge, John; Stohr, Joachim; Stupakov, Gennady; White, Bill; Xiang, Dao

    2009-06-08

    Several recent reports have identified the scientific requirements for a future soft x-ray light source, and a high-repetition-rate free-electron laser (FEL) facility that is responsive to these requirements is now on the horizon. R&D in some critical areas is needed, however, to demonstrate technical performance, thus reducing technical risks and construction costs. Such a facility most likely will be based on a CW superconducting linear accelerator with beam supplied by a high-brightness, high-repetition-rate photocathode electron gun operating in CW mode, and on an array of FELs to which the accelerated beam is distributed, each operating at high repetition rate and with even pulse spacing. Dependent on experimental requirements, the individual FELs can be configured for either self-amplified spontaneous emission (SASE), seeded, or oscillator mode of operation, including the use of high-gain harmonic generation (HGHG), echo-enhanced harmonic generation (EEHG), harmonic cascade, or other configurations. In this White Paper we identify the overall accelerator R&D needs, and highlight the most important pre-construction R&D tasks required to value-engineer the design configuration and deliverables for such a facility. In Section 1.4 we identify the comprehensive R&D ultimately needed. We identify below the highest-priority requirements for understanding machine performance and reduce risk and costs at this pre-conceptual design stage. Details of implementing the required tasks will be the subject of future evaluation. Our highest-priority R&D program is the injector, which must be capable of delivering a beam with bunches up to a nanocoulomb at MHz repetition rate and with normalized emittance {le} 1 mm {center_dot} mrad. This will require integrated accelerating structure, cathode, and laser systems development. Cathode materials will impact the choice of laser technology in wavelength and energy per pulse, as well as vacuum requirements in the accelerating

  12. pubmed.mineR: an R package with text-mining algorithms to analyse PubMed abstracts.

    Science.gov (United States)

    Rani, Jyoti; Shah, A B Rauf; Ramachandran, Srinivasan

    2015-10-01

    The PubMed literature database is a valuable source of information for scientific research. It is rich in biomedical literature with more than 24 million citations. Data-mining of voluminous literature is a challenging task. Although several text-mining algorithms have been developed in recent years with focus on data visualization, they have limitations such as speed, are rigid and are not available in the open source. We have developed an R package, pubmed.mineR, wherein we have combined the advantages of existing algorithms, overcome their limitations, and offer user flexibility and link with other packages in Bioconductor and the Comprehensive R Network (CRAN) in order to expand the user capabilities for executing multifaceted approaches. Three case studies are presented, namely, 'Evolving role of diabetes educators', 'Cancer risk assessment' and 'Dynamic concepts on disease and comorbidity' to illustrate the use of pubmed.mineR. The package generally runs fast with small elapsed times in regular workstations even on large corpus sizes and with compute intensive functions. The pubmed.mineR is available at http://cran.rproject. org/web/packages/pubmed.mineR.

  13. Disruption of CTCF at the miR-125b1 locus in gynecological cancers

    International Nuclear Information System (INIS)

    Soto-Reyes, Ernesto; Herrera, Luis A; González-Barrios, Rodrigo; Cisneros-Soberanis, Fernanda; Herrera-Goepfert, Roberto; Pérez, Víctor; Cantú, David; Prada, Diddier; Castro, Clementina; Recillas-Targa, Félix

    2012-01-01

    In cancer cells, transcriptional gene silencing has been associated with genetic and epigenetic defects. The disruption of DNA methylation patterns and covalent histone marks has been associated with cancer development. Until recently, microRNA (miRNA) gene silencing was not well understood. In particular, miR-125b1 has been suggested to be an miRNA with tumor suppressor activity, and it has been shown to be deregulated in various human cancers. In the present study, we evaluated the DNA methylation at the CpG island proximal to the transcription start site of miR-125b1 in cancer cell lines as well as in normal tissues and gynecological tumor samples. In addition, we analyzed the association of CTCF and covalent histone modifications at the miR-125b1 locus. To assess the DNA methylation status of the miR-125b1, genomic DNA was transformed with sodium bisulfite, and then PCR-amplified with modified primers and sequenced. The miR-125b1 gene expression was analyzed by qRT-PCR using U6 as a control for constitutive gene expression. CTCF repressive histone marks abundance was evaluated by chromatin immunoprecipitation assays. The disruption of CTCF in breast cancer cells correlated with the incorporation of repressive histone marks such H3K9me3 and H3K27me3 as well as with aberrant DNA methylation patterns. To determine the effect of DNA methylation at the CpG island of miR-125b1 on the expression of this gene, we performed a qRT-PCR assay. We observed a significant reduction on the expression of miR-125b1 in cancer cells in comparison with controls, suggesting that DNA methylation at the CpG island might reduce miR-125b1 expression. These effects were observed in other gynecological cancers, including ovarian and cervical tumors. A reduction of miR-125b1 expression in cancers, correlated with methylation, repressive histone marks and loss of CTCF binding at the promoter region

  14. 75 FR 68429 - Cranes and Derricks in Construction; Approval of Information Collection Requirements

    Science.gov (United States)

    2010-11-08

    .... OSHA-2007-0066] RIN 1218-AC01 Cranes and Derricks in Construction; Approval of Information Collection... requirements. SUMMARY: On August 9, 2010, OSHA published a final rule revising the Cranes and Derricks Standard... necessary to protect employees during the use of cranes and derricks in construction. That final standard...

  15. 77 FR 72715 - Informal Entry Limit and Removal of a Formal Entry Requirement

    Science.gov (United States)

    2012-12-06

    ... required certifications, enforcement information, and statistical data. An agency may not conduct or..., 1623, 1624, 3314. * * * * * Sec. 10.1 [Amended] 0 2. In Sec. 10.1: 0 a. Paragraph (a) introductory text... revising``19------'' to read ``20---- --''; 0 c. Paragraph (a)(2) introductory text is amended in the last...

  16. Resistance to organic hydroperoxides requires ohr and ohrR genes in Sinorhizobium meliloti

    Directory of Open Access Journals (Sweden)

    Dufour Virginie

    2011-05-01

    Full Text Available Abstract Background Sinorhizobium meliloti is a symbiotic nitrogen-fixing bacterium that elicits nodules on roots of host plants Medicago sativa. During nodule formation bacteria have to withstand oxygen radicals produced by the plant. Resistance to H2O2 and superoxides has been extensively studied in S. meliloti. In contrast resistance to organic peroxides has not been investigated while S. meliloti genome encodes putative organic peroxidases. Organic peroxides are produced by plants and are highly toxic. The resistance to these oxygen radicals has been studied in various bacteria but never in plant nodulating bacteria. Results In this study we report the characterisation of organic hydroperoxide resistance gene ohr and its regulator ohrR in S. meliloti. The inactivation of ohr affects resistance to cumene and ter-butyl hydroperoxides but not to hydrogen peroxide or menadione in vitro. The expression of ohr and ohrR genes is specifically induced by organic peroxides. OhrR binds to the intergenic region between the divergent genes ohr and ohrR. Two binding sites were characterised. Binding to the operator is prevented by OhrR oxidation that promotes OhrR dimerisation. The inactivation of ohr did not affect symbiosis and nitrogen fixation, suggesting that redundant enzymatic activity exists in this strain. Both ohr and ohrR are expressed in nodules suggesting that they play a role during nitrogen fixation. Conclusions This report demonstrates the significant role Ohr and OhrR proteins play in bacterial stress resistance against organic peroxides in S. meliloti. The ohr and ohrR genes are expressed in nodule-inhabiting bacteroids suggesting a role during nodulation.

  17. R&D for Collider Beauty Physics at the LHC

    CERN Multimedia

    2002-01-01

    We propose an R&D program for the development of a Beauty trigger and innovative elements of the associated spectrometer. The program builds on the success of the recent S$\\bar{p}$pS collider run of the P238 Collaboration, in which clean signals from beam-beam interactions were observed in a large silicon strip microvertex detector running 1.5~mm from the circulating beams. A continuing successful R&D program of the type proposed could ultimately lead to a collider experiment at the LHC to study CP-violation and rare B decays. \\\\ \\\\ We request a fixed target run during late 1992 in order to demonstrate the effectiveness of a heavy flavour trigger which uses real time digital calculations on silicon strip data, implemented with a data driven processor.

  18. Studies on multigap resistive plate chamber prototypes for the new NeuLAND detector at the R3B experiment at FAIR

    Energy Technology Data Exchange (ETDEWEB)

    Elvers, Michael; Endres, Janis; Zilges, Andreas [IKP, Universitaet Koeln (Germany); Aumann, Tom; Boretzky, Konstanze; Hehner, Joerg; Heil, Michael; Prokopowicz, Wawrczek; Reifarth, Rene; Schrieder, Gerhard [Gesellschaft fuer Schwerionenforschung (GSI), Darmstadt (Germany); Bemmerer, Daniel; Stach, Daniel; Wagner, Andreas; Yakorev, Dmitry [Forschungszentrum Dresden-Rossendorf (FZD), Dresden (Germany); Kratz, Jens Volker; Rossi, Dominic [Johannes-Gutenberg-Universitaet, Mainz (Germany)

    2009-07-01

    The NeuLAND detector is part of the R3B experiment at FAIR and will detect neutrons between 0.2 and 1 GeV. The high energy neutrons are converted to charged particles, mainly protons, which are detected by Multigap Resistive Plate Chambers (MRPC). For the detector, a time resolution of {sigma}{sub t} < 100 ps and a position resolution of {sigma}{sub x,y,z} {approx}1 cm is required for given flight paths in the range from 10 to 35 m. An active area of 2 x 2 m{sup 2} of the neutron detector at a distance of 12.5 m to the target will match the angular acceptance of {+-}80 mrad for the neutrons defined by the gap of the superconducting dipole magnet. The salient features of the prototypes are described, as well as electrical measurements and studies with cosmic rays.

  19. Fiscal 1998 industrial science and technology R and D system. R and D report on human media / R and D on the advanced information system technology for oil refinery plants; 1998 nendo seika hokokusho. Human media no kenkyu kaihatsu, sekiyu plant kodo johoka system gijutsu kenkyu kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    As a part of R and D on human media, this report describes the fiscal 1998 result on development of the advanced information system for oil refinery plants. The R and D on human media have been promoted toward construction of a new information system around human beings by advanced integrated media technology since fiscal 1994. The whole concept is body sensation-, heart sensation- and knowledge- friendly media. For safe operation of oil refinery plants, this project develops (1) the intelligent monitoring of measuring instrument information and image information, (2) the display and guidance for facilitating collection of operation data by operator, (3) the modeling for efficient management of previous data and their effective use for current operations, and (4) the autonomous cooperative control technology. In fiscal 1998, the following subsystems were designed and prepared: The interface agent, virtual plant display interface, semantic representation interface, ontology, distributed cooperative processing technology, plant model and interface system. (NEDO)

  20. Simultaneous and multi-criteria optimization of TS requirements and maintenance at NPPs

    International Nuclear Information System (INIS)

    Martorell, S.; Sanchez, A.; Carlos, S.; Serradell, V.

    2002-01-01

    One of the main concerns of the nuclear industry is to improve the availability of safety-related systems at nuclear power plants (NPPs) to achieve high safety levels. The development of efficient testing and maintenance has been traditionally one of the different ways to guarantee high levels of systems availability, which are implemented at NPP through technical specification and maintenance requirements (TS and M). On the other hand, there is a widely recognized interest in using the probabilistic risk analysis (PRA) for risk-informed applications aimed to emphasize both effective risk control and effective resource expenditures at NPPs. TS and M-related parameters in a plant are associated with controlling risk or with satisfying requirements, and are candidate to be evaluated for their resource effectiveness in risk-informed applications. The resource versus risk-control effectiveness principles formally enter in optimization problems where the cost or the burden for the plant staff is to be minimized while the risk or the availability of the safety equipment is constrained to be at a given level, and vice versa. Optimization of TS and M has been found interesting from the very beginning. However, the resolution of such a kind of optimization problem has been limited to focus on only individual TS and M-related parameters (STI, AOT, PM frequency, etc.) and/or adopting an individual optimization criterion (availability, costs, plant risks, etc.). Nevertheless, a number of reasons exist (e.g. interaction, similar scope, etc.) that justify the growing interest in the last years to focus on the simultaneous and multi-criteria optimization of TS and M. In the simultaneous optimization of TS and M-related parameters based on risk (or unavailability) and cost, like in many other engineering optimization problems, one normally faces multi-modal and non-linear objective functions and a variety of both linear and non-linear constraints. Genetic algorithms (GAs) have

  1. Turen går til Second Life

    DEFF Research Database (Denmark)

    Christensen, Inger-Marie F.

    2009-01-01

    Artiklen giver et overblik over Second Life for at gøre det lettere for især nybegyndere at orientere sig og planlægge mere målrettede og dermed succesfulde besøg i den virtuelle verden. Artiklen går ikke i dybden men forsyner læseren med en indledende begrebsafklaring, fakta, praktiske oplysninger...... og links til yderligere information. Sidste del af artiklen indeholder slurls til og beskrivelser af interessant steder i Second Life, som er et besøg værd....

  2. Intrinsic chirality and prochirality at Air/R-(+)- and S-(-)-limonene interfaces: spectral signatures with interference chiral sum-frequency generation vibrational spectroscopy.

    Science.gov (United States)

    Fu, Li; Zhang, Yun; Wei, Zhe-Hao; Wang, Hong-Fei

    2014-09-01

    We report in this work detailed measurements of the chiral and achiral sum-frequency vibrational spectra in the C-H stretching vibration region (2800-3050 cm(-1)) of the air/liquid interfaces of R-(+)-limonene and S-(-)-limonene, using the recently developed high-resolution broadband sum-frequency generation vibrational spectroscopy (HR-BB-SFG-VS). The achiral SFG spectra of R-limonene and S-limonene, as well as the RS racemic mixture (50/50 equal amount mixture), show that the corresponding molecular groups of the R and S enantiomers are with the same interfacial orientations. The interference chiral SFG spectra of the limonene enantiomers exhibit a spectral signature from the chiral response of the Cα-H stretching mode, and a spectral signature from the prochiral response of the CH(2) asymmetric stretching mode, respectively. The chiral spectral feature of the Cα-H stretching mode changes sign from R-(+)-limonene to S-(-)-limonene surfaces, and disappears for the RS racemic mixture surface. While the prochiral spectral feature of the CH(2) asymmetric stretching mode is the same for R-(+)-limonene and S-(-)-limonene surfaces, and also surprisingly remains the same for the RS racemic mixture surface. Therefore, the structures of the R-(+)-limonene and the S-(-)-limonene at the liquid interfaces are nevertheless not mirror images to each other, even though the corresponding groups have the same tilt angle from the interfacial normal, i.e., the R-(+)-limonene and the S-(-)-limonene at the surface are diastereomeric instead of enantiomeric. These results provide detailed information in understanding the structure and chirality of molecular interfaces and demonstrate the sensitivity and potential of SFG-VS as a unique spectroscopic tool for chirality characterization and chiral recognition at the molecular interface. © 2014 Wiley Periodicals, Inc.

  3. r det er svært at være ung i DK

    DEFF Research Database (Denmark)

    Nielsen, Jens Christian; Sørensen, Niels Ulrik; Ozmec, Martha Nina

    I rapporten Når det er svært at være ung i DK – unges trivsel og mistrivsel i tal offentliggør Center for Ungdomsforskning resultaterne af en stor videnskabelig spørgeskemaundersøgelse om trivsel og mistrivsel blandt 15-24-årige unge i Danmark. Rapporten indgår i det treårige forskningsprojekt Når...... det er svært at være ung i DK, som Center for Ungdomsforskning udfører med støtte fra Egmont Fonden. Rapporten bygger på telefoninterviews med 3.481 unge, der udgør et repræsentativt udsnit af alle 15-24-årige unge i Danmark. I rapporten forfølges de unges trivsel og mistrivsel gennem to spor: 1) Et...

  4. Decommissioning of the Nuclear Reactors R2 and R2-0 at Studsvik, Sweden. General Data as called for under Article 37 of the Euratom Treaty

    Energy Technology Data Exchange (ETDEWEB)

    2009-01-15

    This document describes the plans for decommissioning of the nuclear research and material test reactors R2 and R2-0, situated at the Studsvik site close to the city of Nykoeping, Sweden. The purpose of the document is to serve as information for the European Commission, and to fulfil the requirements of Article 37 of the Euratom Treaty. Studsvik is situated on the Baltic coast, about 20 km east of Nykoeping and 80 km southwest of Stockholm. The site comprises the reactors R2 and R2-0 and several facilities for material investigation and radioactive waste treatment and storage. The reactors were used for a number of different purposes from 1960 until June 2005, when they were shut down following a decision by the operator. Decommissioning of the reactor facility is planned to be completed in 2016 after dismantling and conditioning of radioactive parts and demolition of the facility. Solid and liquid radioactive wastes from the dismantling activities will be treated and stored on-site awaiting final disposal. The waste treatment facilities, which are situated in other buildings at the Studsvik site, are planned to continue operation during and after the decommissioning of the reactor facility. All nuclear fuel has been transferred to a separate storage facility and is being shipped to the US according to existing agreements. The objective of the planned dismantling activities is to achieve clearance of the facility to make it possible to either demolish the buildings or use them for other purposes. The operator has divided the planning for dismantling and demolition of the facility into three phases [1]: Dismantling 1, including primary system decontamination, dismantling of the reactors with systems in the reactor pool, draining, cleaning and temporary covering of the reactor pool. This phase has begun and is due to last till approximately December 2009. Dismantling 2, including dismantling of systems in the reactor facility, removal of equipment, radiological

  5. Decommissioning of the Nuclear Reactors R2 and R2-0 at Studsvik, Sweden. General Data as called for under Article 37 of the Euratom Treaty

    International Nuclear Information System (INIS)

    2009-01-01

    This document describes the plans for decommissioning of the nuclear research and material test reactors R2 and R2-0, situated at the Studsvik site close to the city of Nykoeping, Sweden. The purpose of the document is to serve as information for the European Commission, and to fulfil the requirements of Article 37 of the Euratom Treaty. Studsvik is situated on the Baltic coast, about 20 km east of Nykoeping and 80 km southwest of Stockholm. The site comprises the reactors R2 and R2-0 and several facilities for material investigation and radioactive waste treatment and storage. The reactors were used for a number of different purposes from 1960 until June 2005, when they were shut down following a decision by the operator. Decommissioning of the reactor facility is planned to be completed in 2016 after dismantling and conditioning of radioactive parts and demolition of the facility. Solid and liquid radioactive wastes from the dismantling activities will be treated and stored on-site awaiting final disposal. The waste treatment facilities, which are situated in other buildings at the Studsvik site, are planned to continue operation during and after the decommissioning of the reactor facility. All nuclear fuel has been transferred to a separate storage facility and is being shipped to the US according to existing agreements. The objective of the planned dismantling activities is to achieve clearance of the facility to make it possible to either demolish the buildings or use them for other purposes. The operator has divided the planning for dismantling and demolition of the facility into three phases [1]: Dismantling 1, including primary system decontamination, dismantling of the reactors with systems in the reactor pool, draining, cleaning and temporary covering of the reactor pool. This phase has begun and is due to last till approximately December 2009. Dismantling 2, including dismantling of systems in the reactor facility, removal of equipment, radiological

  6. Nuclear data needs for studying the astrophysical r- and p-processes

    International Nuclear Information System (INIS)

    Howard, W.M.; Meyer, B.S.

    1991-09-01

    Recent advances in understanding the astrophysical sites for the r-, p- and 3-processes has led to an increased understanding of the nuclear physics requires to calculate the thermonuclear origin of the heavy elements in nature. We review specific examples of where nuclear information obtained with Radioactive Nuclear Beams can greatly help our understanding of the thermonuclear origin of the elements in nature. 4 figs

  7. Activation of the LRR Receptor-Like Kinase PSY1R Requires Transphosphorylation of Residues in the Activation Loop

    Directory of Open Access Journals (Sweden)

    Christian B. Oehlenschlæger

    2017-11-01

    Full Text Available PSY1R is a leucine-rich repeat (LRR receptor-like kinase (RLK previously shown to act as receptor for the plant peptide hormone PSY1 (peptide containing sulfated tyrosine 1 and to regulate cell expansion. PSY1R phosphorylates and thereby regulates the activity of plasma membrane-localized H+-ATPases. While this mechanism has been studied in detail, little is known about how PSY1R itself is activated. Here we studied the activation mechanism of PSY1R. We show that full-length PSY1R interacts with members of the SERK co-receptor family in planta. We identified seven in vitro autophosphorylation sites on serine and threonine residues within the kinase domain of PSY1R using mass spectrometry. We furthermore show that PSY1R autophosphorylation occurs in trans and that the initial transphosphorylation takes place within the activation loop at residues Ser951, Thr959, and Thr963. While Thr959 and Thr963 are conserved among other related plant LRR RLKs, Ser951 is unique to PSY1R. Based on homology modeling we propose that phosphorylation of Ser951 stabilize the inactive conformation of PSY1R.

  8. Strategic Planning and the Long-term R&D Plan

    International Nuclear Information System (INIS)

    Cooley, J.

    2015-01-01

    The Department of Safeguards of the International Atomic Energy Agency implements a structured strategic planning process to ensure that safeguards will continue to be both effective and efficient in the future. This process provides the Department with a comprehensive and coherent planning framework for the short (2 years), medium (6 years) and long (12 years) term. The Department's suite of planning documents includes a long-term strategic plan and an associated long-term research and development plan as well as a biennial development and implementation support programme. The Department's Long-Term Strategic Plan 2012-2023 addresses the conceptual framework for safeguards implementation, legal authority, technical capabilities (expertise, equipment and infrastructure) and the human and financial resources necessary for Agency verification activities. As research and development (R&D) are essential to meet the safeguards needs of the future, the Department-s Long-Term R&D Plan 2012-2023 is designed to support the Long-Term Strategic Plan 2012-2023 by setting out the capabilities that the Department needs to achieve its strategic objectives, and key milestones towards achieving those capabilities for which Member State R&D support is needed. The Long-Term R&D Plan 2012-2023 addresses the Department's R&D requirements in areas such as safeguards concepts and approaches; detection of undeclared nuclear material and activities; safeguards equipment and communication; information technology, collection, analysis and security; analytical services; new mandates; and training. Long-term capabilities discussed in the presentation include deployed systems (e.g., equipment at facilities); analytical (e.g., sample analysis), operational (e.g., staff expertise and skills) and readiness (e.g., safeguarding new types of facilities) capabilities. To address near-term development objectives and support the implementation of its verification activities as well as to

  9. AUTHORS' STRATEGIES IN THE ENGLISH TEXT (ON THE EXAMPLE OF THE TRILOGY "LORD OF THE RINGS" BY J. R. R. TOLKIEN

    Directory of Open Access Journals (Sweden)

    Suvorova, P.E.

    2016-06-01

    Full Text Available Authors of the article proceed from the assumption that a certain author's orientation in the selection of the artistic worldbuilding can be revealed in any text. This concerns not the stylistic techniques and choice of the artistic means but the detection of formation of strategy and division of a literary text. It describes the process of creating a space-time organization of the text according to the author's task and intention. It is proved that the landscape in the time continuum in the trilogy of J. R. R. Tolkien forms a certain visual impression and transmits information of the associative (psychological type, meaning that, the author's textual strategy is aimed at identifying links between internal and external information about the space-time picture of the world. The authors come to the conclusion about three main strategies in the creation of a space-time model in a trilogy of J. R. R. Tolkien simultaneously implemented in the creation of the visual image, transfer of information of associative type, usage of the landscape and temporal situation description for the implementation and disclosure of basic idea of the work.

  10. Models of dynamical R-parity violation

    Energy Technology Data Exchange (ETDEWEB)

    Csáki, Csaba; Kuflik, Eric [Department of Physics, LEPP, Cornell University, Ithaca, NY 14853 (United States); Slone, Oren; Volansky, Tomer [Raymond and Beverly Sackler School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv 69978 (Israel)

    2015-06-08

    The presence of R-parity violating interactions may relieve the tension between existing LHC constraints and natural supersymmetry. In this paper we lay down the theoretical framework and explore models of dynamical R-parity violation in which the breaking of R-parity is communicated to the visible sector by heavy messenger fields. We find that R-parity violation is often dominated by non-holomorphic operators that have so far been largely ignored, and might require a modification of the existing searches at the LHC. The dynamical origin implies that the effects of such operators are suppressed by the ratio of either the light fermion masses or the supersymmetry breaking scale to the mediation scale, thereby providing a natural explanation for the smallness of R-parity violation. We consider various scenarios, classified by whether R-parity violation, flavor breaking and/or supersymmetry breaking are mediated by the same messenger fields. The most compact case, corresponding to a deformation of the so called flavor mediation scenario, allows for the mediation of supersymmetry breaking, R-parity breaking, and flavor symmetry breaking in a unified manner.

  11. Security concept in 'MyAngelWeb((R))' a website for the individual patient at risk of emergency.

    Science.gov (United States)

    Pinciroli; Nahaissi; Boschini; Ferrari; Meloni; Camnasio; Spaggiari; Carnerone

    2000-11-01

    We describe the Security Plan for the 'MyAngelWeb' service. The different actors involved in the service are subject to different security procedures. The core of the security system is implemented at the host site by means of a DBMS and standard Information Technology tools. Hardware requirements for sustainable security are needed at the web-site construction sites. They are not needed at the emergency physician's site. At the emergency physician's site, a two-way authentication system (password and test phrase method) is implemented.

  12. Search for R-parity-violating supersymmetric particles in multi-jet final states produced in $p$--$p$ collisions at $\\sqrt{s} =$ 13 TeV using the ATLAS detector at the LHC

    CERN Document Server

    Aaboud, Morad; ATLAS Collaboration; Abbott, Brad; Abdinov, Ovsat; Abeloos, Baptiste; Abidi, Syed Haider; Abouzeid, Ossama; Abraham, Nicola; Abramowicz, Halina; Abreu, Henso; Abulaiti, Yiming; Acharya, Bobby Samir; Adachi, Shunsuke; Adamczyk, Leszek; Adelman, Jahred; Adersberger, Michael; Adye, Tim; Affolder, Tony; Afik, Yoav; Agheorghiesei, Catalin; Aguilar Saavedra, Juan Antonio; Ahmadov, Faig; Aielli, Giulio; Akatsuka, Shunichi; Akesson, Torsten Paul Ake; Akilli, Ece; Akimov, Andrei; Alberghi, Gian Luigi; Albert, Justin; Albicocco, Pietro; Alconada Verzini, Maria Josefina; Alderweireldt, Sara Caroline; Aleksa, Martin; Aleksandrov, Igor; Alexa, Calin; Alexander, Gideon; Alexopoulos, Theodoros; Alhroob, Muhammad; Ali, Babar; Aliev, Malik; Alimonti, Gianluca; Alison, John; Alkire, Steven Patrick; Allaire, Corentin; Allbrooke, Benedict; Allen, Benjamin William; Allport, Phillip; Aloisio, Alberto; Alonso, Alejandro; Alonso, Francisco; Alpigiani, Cristiano; Alshehri, Azzah Aziz; Alstaty, Mahmoud; 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Barton, Adam Edward; Bartos, Pavol; Basalaev, Artem; Bassalat, Ahmed; Bates, Richard; Batista, Santiago Juan; Batley, Richard; Battaglia, Marco; Bauce, Matteo; Bauer, Florian; Bauer, Kevin Thomas; Bawa, Harinder Singh; Beacham, James Baker; Beattie, Michael David; Beau, Tristan; Beauchemin, Pierre-Hugues; Bechtle, Philip; Beck, Helge Christoph; Beck, Hans Peter; Becker, Anne Kathrin; Becker, Maurice; Becot, Cyril; Beddall, Ayda; Beddall, Andrew; Bednyakov, Vadim; Bedognetti, Matteo; Bee, Christopher; Beermann, Thomas Alfons; Begalli, Marcia; Begel, Michael; Behr, Katharina; Bell, Andrew Stuart; Bella, Gideon; Bellagamba, Lorenzo; Bellerive, Alain; Bellomo, Massimiliano; Belotskiy, Konstantin; Belyaev, Nikita; Benary, Odette; Benchekroun, Driss; Bender, Michael; Benekos, Nektarios; Benhammou, Yan; Benhar Noccioli, Eleonora; Benitez, Jose; Benjamin, Douglas; Benoit, Mathieu; Bensinger, James; Bentvelsen, Stan; Beresford, Lydia; Beretta, Matteo; Berge, David; Bergeaas Kuutmann, Elin; Berger, Nicolas; Bergsten, Laura Jean; Beringer, Juerg; Berlendis, Simon Paul; Bernard, Nathan Rogers; Bernardi, Gregorio; Bernius, Catrin; Bernlochner, Florian Urs; Berry, Tracey; Berta, Peter; Bertella, Claudia; Bertoli, Gabriele; Bertram, Iain Alexander; Bertsche, Carolyn; Besjes, Geert-jan; Bessidskaia Bylund, Olga; Bessner, Martin Florian; Besson, Nathalie; Bethani, Agni; Bethke, Siegfried; Betti, Alessandra; Bevan, Adrian John; Beyer, Julien-christopher; Bianchi, Riccardo-Maria; Biebel, Otmar; Biedermann, Dustin; Bielski, Rafal; Bierwagen, Katharina; Biesuz, Nicolo Vladi; Biglietti, Michela; Billoud, Thomas Remy Victor; Bindi, Marcello; Bingul, Ahmet; Bini, Cesare; Biondi, Silvia; Bisanz, Tobias; Bittrich, Carsten; Bjergaard, David Martin; Black, James; Black, Kevin; Blair, Robert; Blazek, Tomas; Bloch, Ingo; Blocker, Craig; Blue, Andrew; Blumenschein, Ulrike; Blunier, Sylvain; Bobbink, Gerjan; Bobrovnikov, Victor; Bocchetta, Simona Serena; Bocci, Andrea; Bock, Christopher; Boerner, Daniela; Bogavac, Danijela; Bogdanchikov, Alexander; Bohm, Christian; Boisvert, Veronique; Bokan, Petar; Bold, Tomasz; Boldyrev, Alexey; Bolz, Arthur Eugen; Bomben, Marco; Bona, Marcella; Bonilla, Johan Sebastian; Boonekamp, Maarten; Borisov, Anatoly; Borissov, Guennadi; Bortfeldt, Jonathan; Bortoletto, Daniela; Bortolotto, Valerio; Boscherini, Davide; Bosman, Martine; Bossio Sola, Jonathan David; Boudreau, Joseph; Bouhova-Thacker, Evelina Vassileva; Boumediene, Djamel Eddine; Bourdarios, Claire; Boutle, Sarah Kate; Boveia, Antonio; Boyd, James; Boyko, Igor; Bozson, Adam James; Bracinik, Juraj; Brandt, Andrew; Brandt, Gerhard; Brandt, Oleg; Braren, Frued; Bratzler, Uwe; Brau, Benjamin; Brau, James; Breaden Madden, William Dmitri; Brendlinger, Kurt; Brennan, Amelia Jean; Brenner, Lydia; Brenner, Richard; Bressler, Shikma; Bright-thonney, Samuel Kai; Briglin, Daniel Lawrence; Bristow, Timothy Michael; Britton, Dave; Britzger, Daniel Andreas; Brock, Ian; Brock, Raymond; Brooijmans, Gustaaf; Brooks, Timothy; Brooks, William; 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Celebi, Emre; Ceradini, Filippo; Cerda Alberich, Leonor; Santiago Cerqueira, Augusto; Cerri, Alessandro; Cerrito, Lucio; Cerutti, Fabio; Cervelli, Alberto; Cetin, Serkant Ali; Chafaq, Aziz; Chakraborty, Dhiman; Chan, Stephen Kam-wah; Chan, Wing Sheung; Chan, Yat Long; Chang, Philip; Chapman, John Derek; Charlton, Dave; Chau, Chav Chhiv; Chavez Barajas, Carlos Alberto; Che, Siinn; Chegwidden, Andrew; Chekanov, Sergei; Chekulaev, Sergey; Chelkov, Gueorgui; Chelstowska, Magda Anna; Chen, Cheng; Chen, Chunhui; Chen, Hucheng; Chen, Jing; Chen, Jue; Chen, Shenjian; Chen, Shion; Chen, Xin; Chen, Ye; Cheng, Hok Chuen; Cheng, Huajie; Cheplakov, Alexander; Cheremushkina, Evgenia; Cherkaoui El Moursli, Rajaa; Cheu, Elliott; Cheung, Kingman; Chevalier, Laurent; Chiarella, Vitaliano; Chiarelli, Giorgio; Chiodini, Gabriele; Chisholm, Andrew; Chitan, Adrian; Chiu, Yu Him Justin; Chizhov, Mihail; Choi, Kyungeon; Chomont, Arthur Rene; Chouridou, Sofia; Chow, Yun Sang; Christodoulou, Valentinos; Chu, Ming Chung; 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De Vivie De Regie, Jean-Baptiste; Debenedetti, Chiara; Dedovich, Dmitri; Dehghanian, Nooshin; Deigaard, Ingrid; Del Gaudio, Michela; Del Peso, Jose; Delgove, David; Deliot, Frederic; Delitzsch, Chris Malena; Della Pietra, Massimo; della Volpe, Domenico; Dell'Acqua, Andrea; Dell'Asta, Lidia; Delmastro, Marco; Delporte, Charles; Delsart, Pierre-Antoine; Demarco, David; Demers, Sarah; Demichev, Mikhail; Denisov, Sergey; Denysiuk, Denys; D'eramo, Louis; Derendarz, Dominik; Derkaoui, Jamal Eddine; Derue, Frederic; Dervan, Paul; Desch, Klaus Kurt; Deterre, Cecile; Dette, Karola; Devesa, Maria Roberta; Deviveiros, Pier-Olivier; Dewhurst, Alastair; Dhaliwal, Saminder; Di Bello, Francesco Armando; Di Ciaccio, Anna; Di Ciaccio, Lucia; Di Clemente, William Kennedy; Di Donato, Camilla; Di Girolamo, Alessandro; Di Micco, Biagio; Di Nardo, Roberto; Di Petrillo, Karri Folan; Di Simone, Andrea; Di Sipio, Riccardo; Di Valentino, David; Diaconu, Cristinel; Diamond, Miriam; De Almeida Dias, Flavia; Diaz, Marco Aurelio; 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Faucci Giannelli, Michele; Favareto, Andrea; Fawcett, William James; Fayard, Louis; Fedin, Oleg; Fedorko, Woiciech; Feickert, Matthew; Feigl, Simon; Feligioni, Lorenzo; Feng, Cunfeng; Feng, Eric; Feng, Minyu; Fenton, Michael James; Fenyuk, Alexander; Feremenga, Last; Fernandez Martinez, Patricia; Ferrando, James; Ferrari, Arnaud; Ferrari, Pamela; Ferrari, Roberto; Ferreira de Lima, Danilo Enoque; Ferrer, Antonio; Ferrere, Didier; Ferretti, Claudio; Fiedler, Frank; Filipcic, Andrej; Filthaut, Frank; Fincke-Keeler, Margret; Finelli, Kevin Daniel; Fiolhais, Miguel; Fiorini, Luca; Fischer, Cora; Fischer, Julia; Fisher, Wade Cameron; Flaschel, Nils; Fleck, Ivor; Fleischmann, Philipp; Fletcher, Rob Roy Mac Gregor; Flick, Tobias; Flierl, Bernhard Matthias; Flores, Lucas Macrorie; Flores Castillo, Luis; Fomin, Nikolai; Forcolin, Giulio Tiziano; Formica, Andrea; Foerster, Fabian Alexander; Forti, Alessandra; Foster, Andrew Geoffrey; Fournier, Daniel; Fox, Harald; Fracchia, Silvia; Francavilla, Paolo; Franchini, Matteo; Franchino, Silvia; Francis, David; Franconi, Laura; Franklin, Melissa; Frate, Meghan; Fraternali, Marco; Freeborn, David; Fressard-Batraneanu, Silvia Maria; Freund, Benjamin; Spolidoro Freund, Werner; Froidevaux, Daniel; Frost, James; Fukunaga, Chikara; Fusayasu, Takahiro; Fuster, Juan; Gabizon, Ofir; Gabrielli, Alessandro; Gabrielli, Andrea; Gach, Grzegorz Pawel; Gadatsch, Stefan; Gadomski, Szymon; Gagliardi, Guido; Gagnon, Louis Guillaume; Galea, Cristina; Galhardo, Bruno; Gallas, Elizabeth; Gallop, Bruce; Gallus, Petr; Galster, Gorm Aske Gram; Gamboa Goni, Rodrigo; Gan, KK; Ganguly, Sanmay; Gao, Yanyan; Gao, Yongsheng; Garay Walls, Francisca; García, Carmen; García Navarro, José Enrique; Garcia Pascual, Juan Antonio; Garcia-Sciveres, Maurice; Gardner, Robert; Garelli, Nicoletta; Garonne, Vincent; Gasnikova, Ksenia; Gaudiello, Andrea; Gaudio, Gabriella; Gavrilenko, Igor; Gay, Colin; Gaycken, Goetz; Gazis, Evangelos; Gee, Norman; Geisen, Jannik; Geisen, Marc; Geisler, Manuel Patrice; Gellerstedt, Karl; Gemme, Claudia; Genest, Marie-Helene; Geng, Cong; Gentile, Simonetta; Gentsos, Christos; George, Simon; Gerbaudo, Davide; Gessner, Gregor; Ghasemi, Sara; Ghneimat, Mazuza; Giacobbe, Benedetto; Giagu, Stefano; Giangiacomi, Nico; Giannetti, Paola; Gibson, Stephen; Gignac, Matthew; Gilchriese, Murdock; Gillberg, Dag Ingemar; Gilles, Geoffrey; Gingrich, Douglas; Giordani, MarioPaolo; Giorgi, Filippo Maria; Giraud, Pierre-Francois; Giromini, Paolo; Giugliarelli, Gilberto; Giugni, Danilo; Giuli, Francesco; Giulini, Maddalena; Gkaitatzis, Stamatios; Gkialas, Ioannis; Gkougkousis, Evangelos; Gkountoumis, Panagiotis; Gladilin, Leonid; Glasman, Claudia; Glatzer, Julian Maximilian Volker; Glaysher, Paul; Glazov, Alexandre; Goblirsch-Kolb, Maximilian; Godlewski, Jan; Goldfarb, Steven; Golling, Tobias; Golubkov, Dmitry; Gomes, Agostinho; Goncalo, Ricardo; Goncalves Gama, Rafael; Gonella, Giulia; Gonella, Laura; Gongadze, Alexi; Gonnella, Francesco; Gonski, Julia Lynne; Gonzalez de la Hoz, Santiago; Gonzalez-Sevilla, Sergio; Goossens, Luc; Gorbounov, Petr Andreevich; Gordon, Howard; Gorini, Benedetto; Gorini, Edoardo; Gorisek, Andrej; Goshaw, Alfred; Goessling, Claus; Gostkin, Mikhail Ivanovitch; Gottardo, Carlo Alberto; Goudet, Christophe Raymond; Goujdami, Driss; Goussiou, Anna; Govender, Nicolin; Goy, Corinne; Gozani, Eitan; Grabowska-Bold, Iwona; Gradin, Per Olov Joakim; Graham, Emily Charlotte; Gramling, Johanna; Gramstad, Eirik; Grancagnolo, Sergio; Gratchev, Vadim; Gravila, Paul Mircea; Gray, Chloe; Gray, Heather; Greenwood, Zeno Dixon; Grefe, Christian; Gregersen, Kristian; Gregor, Ingrid-Maria; Grenier, Philippe; Grevtsov, Kirill; Griffiths, Justin; Grillo, Alexander; Grimm, Kathryn; Grinstein, Sebastian; Gris, Philippe Luc Yves; Grivaz, Jean-Francois; Groh, Sabrina; Gross, Eilam; Grosse-Knetter, Jorn; Grossi, Giulio Cornelio; Grout, Zara Jane; Grummer, Aidan; Guan, Liang; Guan, Wen; Guenther, Jaroslav; Guerguichon, Antinea; Guescini, Francesco; Guest, Daniel; Gueta, Orel; Gugel, Ralf; Gui, Bin; Guillemin, Thibault; Guindon, Stefan; Gul, Umar; Gumpert, Christian; Guo, Jun; Guo, Wen; Guo, Yicheng; Gupta, Ruchi; Gurbuz, Saime; Gustavino, Giuliano; Gutelman, Benjamin Jacque; Gutierrez, Phillip; Gutierrez Ortiz, Nicolas Gilberto; Gutschow, Christian; Guyot, Claude; Guzik, Marcin Pawel; Gwenlan, Claire; Gwilliam, Carl; Haas, Andy; Haber, Carl; Hadavand, Haleh Khani; Haddad, Nacim; Hadef, Asma; Hageboeck, Stephan; Hagihara, Mutsuto; Hakobyan, Hrachya; Haleem, Mahsana; Haley, Joseph; Halladjian, Garabed; Hallewell, Gregory David; Hamacher, Klaus; Hamal, Petr; Hamano, Kenji; Hamilton, Andrew; Hamity, Guillermo Nicolas; Han, Kunlin; Han, Liang; Han, Shuo; Hanagaki, Kazunori; Hance, Michael; Handl, David Michael; Haney, Bijan; Hankache, Robert; Hanke, Paul; Hansen, Eva; Hansen, Jorgen Beck; Hansen, Jorn Dines; Hansen, Maike Christina; Hansen, Peter Henrik; Hara, Kazuhiko; Hard, Andrew Straiton; Harenberg, Torsten; Hariri, Faten; Harkusha, Siarhei; Harrison, Paul Fraser; Hartmann, Nikolai Marcel; Hasegawa, Yoji; Hasib, Ahmed; Hassani, Samira; Haug, Sigve; Hauser, Reiner; Hauswald, Lorenz; Havener, Laura Brittany; Havranek, Miroslav; Hawkes, Christopher; Hawkings, Richard; Hayden, Daniel; Hays, Chris; Hays, Jonathan Michael; Hayward, Helen; Haywood, Stephen; Heck, Tobias; Hedberg, Vincent; Heelan, Louise; Heer, Sebastian; Heidegger, Kim Katrin; Heim, Sarah; Heim, Timon Frank-thomas; Heinemann, Beate; Heinrich, Jochen Jens; Heinrich, Lukas; Heinz, Christian; Hejbal, Jiri; Helary, Louis; Held, Alexander; Hellman, Sten; Helsens, Clement; Henderson, Robert; Heng, Yang; Henkelmann, Steffen; Henriques Correia, Ana Maria; Herbert, Geoffrey Henry; Herde, Hannah; Herget, Verena; Hernandez Jimenez, Yesenia; Herr, Holger; Herten, Gregor; Hertenberger, Ralf; Hervas, Luis; Herwig, Theodor Christian; Hesketh, Gavin Grant; Hessey, Nigel; Hetherly, Jeffrey Wayne; Higashino, Satoshi; Higon-Rodriguez, Emilio; Hildebrand, Kevin; Hill, Ewan; Hill, John; Hiller, Karl Heinz; Hillier, Stephen; Hils, Maximilian; Hinchliffe, Ian; Hirose, Minoru; Hirschbuehl, Dominic; Hiti, Bojan; Hladik, Ondrej; Hlaluku, Dingane Reward; Hoad, Xanthe; Hobbs, John; Hod, Noam; Hodgkinson, Mark; Hoecker, Andreas; Hoeferkamp, Martin; Hoenig, Friedrich; Hohn, David; Hohov, Dmytro; Holmes, Tova Ray; Holzbock, Michael; Homann, Michael; Honda, Shunsuke; Honda, Takuya; Hong, Tae Min; Hooberman, Benjamin Henry; Hopkins, Walter Howard; Horii, Yasuyuki; Horton, Arthur James; Hostachy, Jean-Yves; Hostiuc, Alexandru; Hou, Suen; Hoummada, Abdeslam; Howarth, James; Hoya, Joaquin; Hrabovsky, Miroslav; Hrdinka, Julia; Hristova, Ivana; Hrivnac, Julius; Hrynevich, Aliaksei; Hryn'ova, Tetiana; Hsu, Pai-hsien Jennifer; Hsu, Shih-Chieh; Hu, Qipeng; Hu, Shuyang; Huang, Yanping; Hubacek, Zdenek; Hubaut, Fabrice; Huegging, Fabian; Huffman, Todd Brian; Hughes, Emlyn; Huhtinen, Mika; Hunter, Robert Francis; Huo, Peng; Hupe, Andre Marc; Huseynov, Nazim; Huston, Joey; Huth, John; Hyneman, Rachel; Iacobucci, Giuseppe; Iakovidis, Georgios; Ibragimov, Iskander; Iconomidou-Fayard, Lydia; Idrissi, Zineb; Iengo, Paolo; Igonkina, Olga; Iguchi, Ryunosuke; Iizawa, Tomoya; Ikegami, Yoichi; Ikeno, Masahiro; Iliadis, Dimitrios; Ilic, Nikolina; Iltzsche Speiser, Franziska; Introzzi, Gianluca; Iodice, Mauro; Iordanidou, Kalliopi; Ippolito, Valerio; Isacson, Max Fredrik; Ishijima, Naoki; Ishino, Masaya; Ishitsuka, Masaki; Issever, Cigdem; Istin, Serhat; Ito, Fumiaki; Iturbe Ponce, Julia Mariana; Iuppa, Roberto; Iwasaki, Hiroyuki; Izen, Joseph; Izzo, Vincenzo; Jabbar, Samina; Jackson, Paul; Jacobs, Ruth Magdalena; Jain, Vivek; Jakel, Gunnar; Jakobi, Katharina Bianca; Jakobs, Karl; Jakobsen, Sune; Jakoubek, Tomas; Jamin, David Olivier; Jana, Dilip; Jansky, Roland; Janssen, Jens; Janus, Michel; Janus, Piotr Andrzej; Jarlskog, Goeran; Javadov, Namig; Javurek, Tomas; Javurkova, Martina; Jeanneau, Fabien; Jeanty, Laura; Jejelava, Juansher; Jelinskas, Adomas; Jenni, Peter; Jeske, Carl; Jezequel, Stephane; Ji, Haoshuang; Jia, Jiangyong; Jiang, Hai; Jiang, Yi; Jiang, Zihao; Jiggins, Stephen; Jimenez Pena, Javier; Jin, Shan; Jinaru, Adam; Jinnouchi, Osamu; Jivan, Harshna; Johansson, Per; Johns, Kenneth; Johnson, Christian; Johnson, William Joseph; Jon-And, Kerstin; Jones, Roger; Jones, Samuel David; Jones, Sarah; Jones, Tim; Jongmanns, Jan; Jorge, Pedro; Jovicevic, Jelena; Ju, Xiangyang; Juste Rozas, Aurelio; Kaczmarska, Anna; Kado, Marumi; Kagan, Harris; Kagan, Michael; Kahn, Sebastien Jonathan; Kaji, Toshiaki; Kajomovitz, Enrique; Kalderon, Charles William; Kaluza, Adam; Kama, Sami; Kamenshchikov, Andrey; Kanjir, Luka; Kano, Yuya; Kantserov, Vadim; Kanzaki, Junichi; Kaplan, Benjamin; Kaplan, Laser Seymour; Kar, Deepak; Karakostas, Konstantinos; Karastathis, Nikolaos; Kareem, Mohammad Jawad; Karentzos, Efstathios; Karpov, Sergey; Karpova, Zoya; Kartvelishvili, Vakhtang; Karyukhin, Andrey; Kasahara, Kota; Kashif, Lashkar; Kass, Richard; Kastanas, Alex; Kataoka, Yousuke; Kato, Chikuma; Katre, Akshay; Katzy, Judith; Kawade, Kentaro; Kawagoe, Kiyotomo; Kawamoto, Tatsuo; Kawamura, Gen; Kay, Ellis Fawn; Kazanin, Vassili; Keeler, Richard; Kehoe, Robert; Keller, John Stakely; Kellermann, Edgar; Kempster, Jacob Julian; Kendrick, James Andrew; Keoshkerian, Houry; Kepka, Oldrich; Kersten, Susanne; Kersevan, Borut Paul; Keyes, Robert; Khader, Mazin; Khalil-zada, Farkhad; Khanov, Alexander; Kharlamov, Alexey; Kharlamova, Tatyana; Khodinov, Alexander; Khoo, Teng Jian; Khovanskiy, Valery; Khramov, Evgeniy; Khubua, Jemal; Kido, Shogo; Kiehn, Moritz; Kilby, Callum Robert; Kim, Hee Yeun; Kim, Shinhong; Kim, Young-Kee; Kimura, Naoki; Kind, Oliver; King, Barry; Kirchmeier, David; Kirk, Julie; Kiryunin, Andrey; Kishimoto, Tomoe; Kisielewska, Danuta; Kitali, Vincent; Kivernyk, Oleh; Kladiva, Eduard; Klapdor-kleingrothaus, Thorwald; Klein, Matthew Henry; Klein, Max; Klein, Uta; Kleinknecht, Konrad; Klimek, Pawel; Klimentov, Alexei; Klingenberg, Reiner; Klingl, Tobias; Klioutchnikova, Tatiana; Klitzner, Felix Fidelio; Kluit, Peter; Kluth, Stefan; Kneringer, Emmerich; Knoops, Edith B F G; Knue, Andrea; Kobayashi, Aine; Kobayashi, Dai; Kobayashi, Tomio; Kobel, Michael; Kocian, Martin; Kodys, Peter; Koffas, Thomas; Koffeman, Els; Koehler, Nicolas Maximilian; Koi, Tatsumi; Kolb, Mathis; Koletsou, Iro; Kondo, Takahiko; Kondrashova, Natalia; Koeneke, Karsten; Koenig, Adriaan; Kono, Takanori; Konoplich, Rostislav; Konstantinidis, Nikolaos; Konya, Balazs; Kopeliansky, Revital; Koperny, Stefan; Korcyl, Krzysztof; Kordas, Konstantinos; Korn, Andreas; Korolkov, Ilya; Korolkova, Elena; Kortner, Oliver; Kortner, Sandra; Kosek, Tomas; Kostyukhin, Vadim; Kotwal, Ashutosh; Koulouris, Aimilianos; Kourkoumeli-Charalampidi, Athina; Kourkoumelis, Christine; Kourlitis, Evangelos; Kouskoura, Vasiliki; Kowalewska, Anna Bozena; Kowalewski, Robert Victor; Kowalski, Tadeusz; Kozakai, Chihiro; Kozanecki, Witold; Kozhin, Anatoly; Kramarenko, Viktor; Kramberger, Gregor; Krasnopevtsev, Dimitrii; Krasny, Mieczyslaw Witold; Krasznahorkay, Attila; Krauss, Dominik; Kremer, Jakub Andrzej; Kretzschmar, Jan; Kreutzfeldt, Kristof; Krieger, Peter; Krizka, Karol; Kroeninger, Kevin; Kroha, Hubert; Kroll, Jiri; Kroll, Joe; Kroseberg, Juergen; Krstic, Jelena; Kruchonak, Uladzimir; Krueger, Hans; Krumnack, Nils; Kruse, Mark; Kubota, Takashi; Kuday, Sinan; Kuechler, Jan Thomas; Kuehn, Susanne; Kugel, Andreas; Kuger, Fabian; Kuhl, Thorsten; Kukhtin, Victor; Kukla, Romain; Kulchitsky, Yuri; Kuleshov, Sergey; Kulinich, Yakov Petrovich; Kuna, Marine; Kunigo, Takuto; Kupco, Alexander; Kupfer, Tobias; Kuprash, Oleg; Kurashige, Hisaya; Kurchaninov, Leonid; Kurochkin, Yurii; Kurth, Matthew Glenn; Kuwertz, Emma Sian; Kuze, Masahiro; Kvita, Jiri; Kwan, Tony; La Rosa, Alessandro; La Rosa Navarro, Jose Luis; La Rotonda, Laura; La Ruffa, Francesco; Lacasta, Carlos; Lacava, Francesco; Lacey, James; Lack, David Philip John; Lacker, Heiko; Lacour, Didier; Ladygin, Evgueni; Lafaye, Remi; Laforge, Bertrand; Lai, Stanley; Lammers, Sabine; Lampl, Walter; Lancon, Eric; Landgraf, Ulrich; Landon, Murrough; Lanfermann, Marie Christine; Lang, Valerie Susanne; Lange, Joern Christian; Langenberg, Robert Johannes; Lankford, Andrew; Lanni, Francesco; Lantzsch, Kerstin; Lanza, Agostino; Lapertosa, Alessandro; Laplace, Sandrine; Laporte, Jean-Francois; Lari, Tommaso; Lasagni Manghi, Federico; Lassnig, Mario; Lau, Tak Shun; Laudrain, Antoine; Law, Alexander Thomas; Laycock, Paul; Lazzaroni, Massimo; Le, Brian; Le Dortz, Olivier; Le Guirriec, Emmanuel; Le Quilleuc, Eloi Paul; Leblanc, Matthew Edgar; LeCompte, Thomas; Ledroit-Guillon, Fabienne; Lee, Claire Alexandra; Lee, Graham Richard; Lee JR, Lawrence; Lee, Shih-Chang; Lefebvre, Benoit; Lefebvre, Michel; Legger, Federica; Leggett, Charles; Lehmann Miotto, Giovanna; Leight, William Axel; Leisos, Antonios; Leite, Marco Aurelio Lisboa; Leitner, Rupert; Lellouch, Daniel; Lemmer, Boris; Leney, Katharine; Lenz, Tatjana; Lenzi, Bruno; Leone, Robert; Leone, Sandra; Leonidopoulos, Christos; Lerner, Giuseppe; Leroy, Claude; Les, Robert; Lesage, Arthur; Lester, Christopher; Levchenko, Mikhail; Leveque, Jessica; Levin, Daniel; Levinson, Lorne; Levy, Mark; Lewis, Dave; Li, Bing; Li, Changqiao; Li, Haifeng; Li, Liang; Li, Qi; Li, Quanyin; Li, Shu; Li, Xingguo; Li, Yichen; Liang, Zhijun; Liberti, Barbara; Liblong, Aaron; Lie, Ki; Limosani, Antonio; Lin, Chiao-ying; Lin, Kuan-yu; Lin, Simon; Lin, Tai-hua; Linck, Rebecca Anne; Lindquist, Brian Edward; Lionti, Anthony Eric; Lipeles, Elliot; Lipniacka, Anna; Lisovyi, Mykhailo; Liss, Tony; Lister, Alison; Litke, Alan; Liu, Bo; Liu, Hongbin; Liu, Hao; Liu, Jianbei; Liu, Jesse Kar Kee; Liu, Kun; Liu, Minghui; Liu, Peilian; Liu, Yanwen; Liu, Yanlin; Livan, Michele; Lleres, Annick; Llorente Merino, Javier; Lloyd, Stephen; Lo, Cheuk Yee; Lo Sterzo, Francesco; Lobodzinska, Ewelina; Loch, Peter; Loebinger, Fred; Loesle, Alena; Loew, Kevin Michael; Lohse, Thomas; Lohwasser, Kristin; Lokajicek, Milos; Long, Brian Alexander; Long, Jonathan; Long, Robin Eamonn; Longo, Luigi; Looper, Kristina Anne; Lopez Lopez, Jorge Andres; Lopez Paz, Ivan; Lopez Solis, Alvaro; Lorenz, Jeanette; Lorenzo Martinez, Narei; Losada, Marta; Losel, Philipp Jonathan; Lou, Xinchou; Lounis, Abdenour; Love, Jeremy; Love, Peter; Lu, Haonan; Lu, Nan; Lu, Sicong; Lu, Yun-Ju; Lubatti, Henry; Luci, Claudio; Lucotte, Arnaud; Luedtke, Christian; Luehring, Fred; Lukas, Wolfgang; Luminari, Lamberto; Lund-Jensen, Bengt; Lutz, Margaret Susan; Luzi, Pierre Marc; Lynn, David; Lysak, Roman; Lytken, Else; Lyu, Feng; Lyubushkin, Vladimir; Ma, Hong; Ma, LianLiang; Ma, Yanhui; Maccarrone, Giovanni; Macchiolo, Anna; Macdonald, Calum Michael; Machado Miguens, Joana; Madaffari, Daniele; Madar, Romain; Mader, Wolfgang; Madsen, Alexander; Madysa, Nico; Maeda, Jumpei; Maeland, Steffen; Maeno, Tadashi; Maevskiy, Artem; Magerl, Veronika; Maidantchik, Carmen; Maier, Thomas; Maio, Amelia; Majersky, Oliver; Majewski, Stephanie; Makida, Yasuhiro; Makovec, Nikola; Malaescu, Bogdan; Malecki, Pawel; Maleev, Victor; Malek, Fairouz; Mallik, Usha; Malon, David; Malone, Claire; Maltezos, Stavros; Malyukov, Sergei; Mamuzic, Judita; Mancini, Giada; Mandic, Igor; Maneira, Jose; Manhaes de Andrade Filho, Luciano; Manjarres Ramos, Joany Andreina; Mankinen, Katja Hannele; Mann, Alexander; Manousos, Athanasios; Mansoulie, Bruno; Mansour, Jason Dhia; Mantifel, Rodger; Mantoani, Matteo; Manzoni, Stefano; Marceca, Gino; March Ruiz, Luis; Marchese, Luigi; Marchiori, Giovanni; Marcisovsky, Michal; Marin Tobon, Cesar Augusto; Marjanovic, Marija; Marley, Daniel Edison; Marroquim, Fernando; Marshall, Zach; Martensson, Ulf Fredrik Mikael; Marti i Garcia, Salvador; Martin, Christopher Blake; Martin, Tim; Martin, Victoria Jane; Martin dit Latour, Bertrand; Martinez Perez, Mario; Martinez Outschoorn, Verena; Martin-Haugh, Stewart; Martoiu, Victor Sorin; Martyniuk, Alex; Marzin, Antoine; Masetti, Lucia; Mashimo, Tetsuro; Mashinistov, Ruslan; Masik, Jiri; Maslennikov, Alexey; Mason, Lara Hannan; Massa, Lorenzo; Mastrandrea, Paolo; Mastroberardino, Anna; Masubuchi, Tatsuya; Maettig, Peter; Maurer, Julien; Macek, Bostjan; Maxfield, Stephen; Maximov, Dmitriy; Mazini, Rachid; Maznas, Ioannis; Mazza, Simone Michele; Mc Fadden, Neil Christopher; Mc Goldrick, Garrin; Mc Kee, Shawn Patrick; McCarn, Allison; McCarthy, Tom; McClymont, Laurie Iain; McDonald, Emily; Mcfayden, Joshua Angus; Mchedlidze, Gvantsa; McKay, Madalyn Ann; McMahon, Steve; Mcnamara, Peter Charles; Mcnicol, Christopher John; McPherson, Robert; Meadows, Zachary Alden; Meehan, Samuel; Megy, Theo Jean; Mehlhase, Sascha; Mehta, Andrew; Meideck, Thomas; Meirose, Bernhard; Melini, Davide; Mellado Garcia, Bruce Rafael; Mellenthin, Johannes Donatus; Melo, Matej; Meloni, Federico; Melzer, Alexander; Menary, Stephen Burns; Meng, Lingxin; Meng, Xiangting; Mengarelli, Alberto; Menke, Sven; Meoni, Evelin; Mergelmeyer, Sebastian; Merlassino, Claudia; Mermod, Philippe; Merola, Leonardo; Meroni, Chiara; Merritt, Frank; Messina, Andrea; Metcalfe, Jessica; Mete, Alaettin Serhan; Meyer, Christopher; Meyer, Jochen; Meyer, Jean-Pierre; Meyer Zu Theenhausen, Hanno; Miano, Fabrizio; Middleton, Robin; Miglioranzi, Silvia; Mijovic, Liza; Mikenberg, Giora; Mikestikova, Marcela; Mikuz, Marko; Milesi, Marco; Milic, Adriana; Millar, Declan Andrew; Miller, David; Milov, Alexander; Milstead, David; Minaenko, Andrey; Minashvili, Irakli; Mincer, Allen; Mindur, Bartosz; Mineev, Mikhail; Minegishi, Yuji; Ming, Yao; Mir, Lluisa-Maria; Mirto, Alessandro; Mistry, Khilesh Pradip; Mitani, Takashi; Mitrevski, Jovan; Mitsou, Vasiliki A; Miucci, Antonio; Miyagawa, Paul; Mizukami, Atsushi; Mjoernmark, Jan-Ulf; Mkrtchyan, Tigran; Mlynarikova, Michaela; Moa, Torbjoern; Mochizuki, Kazuya; Mogg, Philipp; Mohapatra, Soumya; Molander, Simon; Moles-Valls, Regina; Mondragon, Matthew Craig; Moenig, Klaus; Monk, James; Monnier, Emmanuel; Montalbano, Alyssa; Montejo Berlingen, Javier; Monticelli, Fernando; Monzani, Simone; Moore, Roger; Morange, Nicolas; Moreno, Deywis; Moreno Llacer, Maria; Morettini, Paolo; Morgenstern, Marcus; Morgenstern, Stefanie; Mori, Daniel; Mori, Tatsuya; Morii, Masahiro; Morinaga, Masahiro; Morisbak, Vanja; Morley, Anthony Keith; Mornacchi, Giuseppe; Morris, John; Morvaj, Ljiljana; Moschovakos, Paraschos; Mosidze, Maia; Moss, Harry James; Moss, Josh; Motohashi, Kazuki; Mount, Richard; Mountricha, Eleni; Moyse, Edward; Muanza, Steve; Mueller, Felix; Mueller, James; Mueller, Ralph Soeren Peter; Muenstermann, Daniel; Mullen, Paul; Mullier, Geoffrey Andre; Munoz Sanchez, Francisca Javiela; Murin, Pavel; Murray, Bill; Muskinja, Miha; Mwewa, Chilufya; Myagkov, Alexey; Myers, John; Myska, Miroslav; Nachman, Benjamin Philip; Nackenhorst, Olaf; Nagai, Koichi; Nagai, Ryo; Nagano, Kunihiro; Nagasaka, Yasushi; Nagata, Kazuki; Nagel, Martin; Nagy, Elemer; Nairz, Armin Michael; Nakahama, Yu; Nakamura, Koji; Nakamura, Tomoaki; Nakano, Itsuo; Naranjo Garcia, Roger Felipe; Narayan, Rohin; Narrias Villar, Daniel Isaac; Naryshkin, Iouri; Naumann, Thomas; Navarro, Gabriela; Nayyar, Ruchika; Neal, Homer; Nechaeva, Polina; Neep, Thomas James; Negri, Andrea; Negrini, Matteo; Nektarijevic, Snezana; Nellist, Clara Jean May; Nelson, Michael Edward; Nemecek, Stanislav; Nemethy, Peter; Nessi, Marzio; Neubauer, Mark; Neumann, Manuel; Newman, Paul; Ng, Tsz Yu; Ng, Yan Wing; Nguyen Manh, Tuan; Nickerson, Richard; Nicolaidou, Rosy; Nielsen, Jason; Nikiforou, Nikiforos; Nikolaenko, Vladimir; Nikolic-Audit, Irena; Nikolopoulos, Konstantinos; Nilsson, Paul; Ninomiya, Yoichi; Nisati, Aleandro; Nishu, Nishu; Nisius, Richard; Nitsche, Isabel; Nitta, Tatsumi; Nobe, Takuya; Noguchi, Yohei; Nomachi, Masaharu; Nomidis, Ioannis; Nomura, Marcelo Ayumu; Nooney, Tamsin; Nordberg, Markus; BIN NORJOHARUDDEEN, Nurfikri; Novgorodova, Olga; Novotny, Radek; Nozaki, Mitsuaki; Nozka, Libor; Ntekas, Konstantinos; Nurse, Emily; Nuti, Francesco; Oakham, Gerald; Oberlack, Horst; Obermann, Theresa; Ocariz, Jose; Ochi, Atsuhiko; Abreu Juliao Ochoa De Castro, Maria Ines; Ochoa, Jean-pierre; O'Connor, Kelsey; Oda, Susumu; Odaka, Shigeru; Oh, Alexander; Oh, Seog; Ohm, Christian; Ohman, Henrik; Oide, Hideyuki; Okawa, Hideki; Okumura, Yasuyuki; Okuyama, Toyonobu; Olariu, Albert; Oleiro Seabra, Luis Filipe; Olivares Pino, Sebastian Andres; Oliveira Damazio, Denis; Oliver, Jason Lea; Olsson, Mats Joakim Robert; Olszewski, Andrzej; Olszowska, Jolanta; O'Neil, Dugan; Onofre, Antonio; Onogi, Kouta; Onyisi, Peter; Oppen, Henrik; Oreglia, Mark; Oren, Yona; Orestano, Domizia; Orgill, Emily Claire; Orlando, Nicola; O'Rourke, Abigail Alexandra; Orr, Robert; Osculati, Bianca; O'Shea, Val; Ospanov, Rustem; Otero y Garzon, Gustavo; Otono, Hidetoshi; Ouchrif, Mohamed; Ould-Saada, Farid; Ouraou, Ahmimed; Oussoren, Koen Pieter; Ouyang, Qun; Owen, Mark; Owen, Rhys Edward; Ozcan, Veysi Erkcan; Ozturk, Nurcan; Pachal, Katherine; Pacheco Pages, Andres; Pacheco Rodriguez, Laura; Padilla Aranda, Cristobal; Pagan Griso, Simone; Paganini, Michela; Paige, Frank; Palacino, Gabriel; Palazzo, Serena; Palestini, Sandro; Palka, Marek; 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Price, Darren; Primavera, Margherita; Prince, Sebastien; Proklova, Nadezda; Prokofiev, Kirill; Prokoshin, Fedor; Protopopescu, Serban; Proudfoot, James; Przybycien, Mariusz; Puri, Akshat; Puzo, Patrick; Qian, Jianming; Qin, Yang; Quadt, Arnulf; Queitsch-maitland, Michaela; Qureshi, Anum; Radeka, Veljko; Radhakrishnan, Sooraj Krishnan; Rados, Petar Kevin; Ragusa, Francesco; Rahal, Ghita; Raine, John Andrew; Rajagopalan, Srinivasan; Rashid, Tasneem; Raspopov, Sergii; Ratti, Maria Giulia; Rauch, Daniel Mauricio; Rauscher, Felix; Rave, Stefan; Ravinovich, Ilia; Rawling, Jacob Henry; Raymond, Michel; Read, Alexander Lincoln; Readioff, Nathan Peter; Reale, Marilea; Rebuzzi, Daniela; Redelbach, Andreas; Redlinger, George; Reece, Ryan; Reed, Robert; Reeves, Kendall; Rehnisch, Laura; Reichert, Joseph; Reiss, Andreas; Rembser, Christoph; Ren, Huan; Rescigno, Marco; Resconi, Silvia; Resseguie, Elodie Deborah; Rettie, Sebastien; Reynolds, Elliot; Rezanova, Olga; Reznicek, Pavel; Richter, Robert; Richter, Stefan; 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Rothberg, Joseph; Rousseau, David; Roy, Debarati; Rozanov, Alexander; Rozen, Yoram; Ruan, Xifeng; Rubbo, Francesco; Ruehr, Frederik; Ruiz-Martinez, Aranzazu; Rurikova, Zuzana; Rusakovich, Nikolai; Russell, Heather Lynn; Rutherfoord, John; Ruthmann, Nils; Ruttinger, Elias Michael; Ryabov, Yury; Rybar, Martin; Rybkin, Grigori; Ryu, Soo; Ryzhov, Andrey; Rzehorz, Gerhard Ferdinand; Sabato, Gabriele; Sacerdoti, Sabrina; Sadrozinski, Hartmut; Sadykov, Renat; Safai Tehrani, Francesco; Saha, Puja; Sahinsoy, Merve; Saimpert, Matthias; Saito, Masahiko; Saito, Tomoyuki; Sakamoto, Hiroshi; Sakharov, Alexander; Salamanna, Giuseppe; Salazar Loyola, Javier Esteban; Salek, David; Sales De Bruin, Pedro Henrique; Salihagic, Denis; Salnikov, Andrei; Salt, José; Salvatore, Daniela; Salvatore, Pasquale Fabrizio; Salvucci, Antonio; Salzburger, Andreas; Sammel, Dirk; Sampsonidis, Dimitrios; Sampsonidou, Despoina; Sánchez, Javier; Sanchez Pineda, Arturo Rodolfo; Sandaker, Heidi; Sandbach, Ruth Laura; Sander, Christian Oliver; 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Thiele, Fabian; Thomas, Juergen; Thomas-Wilsker, Joshuha; Thompson, Stan; Thompson, Paul; Thomsen, Lotte Ansgaard; Thomson, Evelyn; Tian, Yun; Ticse Torres, Royer Edson; Tikhomirov, Vladimir; Tikhonov, Yury; Timoshenko, Sergey; Tipton, Paul; Tisserant, Sylvain; Todome, Kazuki; Todorova-Nova, Sharka; Todt, Stefanie; Tojo, Junji; Tokar, Stanislav; Tokushuku, Katsuo; Tolley, Emma; Tomoto, Makoto; Tompkins, Lauren; Toms, Konstantin; Tong, Baojia; Tornambe, Peter; Torrence, Eric; Torres, Heberth; Torro Pastor, Emma; Toth, Jozsef; Touchard, Francois; Tovey, Daniel; Treado, Colleen Jennifer; Trefzger, Thomas; Tresoldi, Fabio; Tricoli, Alessandro; Trigger, Isabel Marian; Trincaz-Duvoid, Sophie; Tripiana, Martin; Trischuk, William; Trocme, Benjamin; Trofymov, Artur; Troncon, Clara; Trovatelli, Monica; Truong, Loan; Trzebinski, Maciej; Trzupek, Adam; Tsang, Ka Wa; Tseng, Jeffrey; Tsiareshka, Pavel; Tsirintanis, Nikolaos; Tsiskaridze, Shota; Tsiskaridze, Vakhtang; Tskhadadze, Edisher; Tsukerman, Ilya; 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Sfiligoj, Tina; Vuillermet, Raphael; Vukotic, Ilija; Zenis, Tibor; Zivkovic, Lidija; Wagner, Peter; Wagner, Wolfgang; Wagner-kuhr, Jeannine; Wahlberg, Hernan; Wahrmund, Sebastian; Wakamiya, Kotaro; Walder, James; Walker, Rodney; Walkowiak, Wolfgang; Wallangen, Veronica; Wang, Ann Miao; Wang, Chao; Wang, Fuquan; Wang, Haichen; Wang, Hulin; Wang, Jin; Wang, Jike; Wang, Qing; Wang, Renjie; Wang, Rui; Wang, Song-Ming; Wang, Tingting; Wang, Wei; Wang, Wenxiao; Wang, Zirui; Wanotayaroj, Chaowaroj; Warburton, Andreas; Ward, Patricia; Wardrope, David Robert; Washbrook, Andrew; Watkins, Peter; Watson, Alan; Watson, Miriam; Watts, Gordon; Watts, Stephen; Waugh, Ben; Webb, Aaron Foley; Webb, Samuel; Weber, Michele; Weber, Stephen Albert; Weber, Sebastian Mario; Webster, Jordan S; Weidberg, Anthony; Weinert, Benjamin; Weingarten, Jens; Weirich, Marcel; Weiser, Christian; Wells, Pippa; Wenaus, Torre; Wengler, Thorsten; Wenig, Siegfried; Wermes, Norbert; Werner, Michael David; Werner, Per; Wessels, Martin; Weston, Thomas Daniel; Whalen, Kathleen; Whallon, Nikola Lazar; Wharton, Andrew Mark; White, Aaron; White, Andrew; White, Martin; White, Ryan; Whiteson, Daniel; Whitmore, Ben William; Wickens, Fred; Wiedenmann, Werner; Wielers, Monika; Wiglesworth, Craig; Wiik, Liv Antje Mari; Wildauer, Andreas; Wilk, Fabian; Wilkens, Henric George; Williams, Hugh; Williams, Sarah; Willis, Christopher; Willocq, Stephane; Wilson, John; Wingerter-Seez, Isabelle; Winkels, Emma; Winklmeier, Frank; Winston, Oliver James; Winter, Benedict Tobias; Wittgen, Matthias; Wobisch, Markus; Wolf, Anton; Wolf, Tim Michael Heinz; Wolff, Robert; Wolter, Marcin Wladyslaw; Wolters, Helmut; Wong, Vincent Wai Sum; Woods, Natasha Lee; Worm, Steven; Wosiek, Barbara; Wozniak, Krzysztof; Wu, Miles; Wu, Sau Lan; Wu, Xin; Wu, Yusheng; Wyatt, Terry Richard; Wynne, Benjamin; Xella, Stefania; Xi, Zhaoxu; Xia, Ligang; Xu, Da; Xu, Lailin; Xu, Tairan; Xu, Wenhao; Yabsley, Bruce; Yacoob, Sahal; Yajima, Kazuki; Yallup, David Paul; Yamaguchi, Daiki; Yamaguchi, Yohei; Yamamoto, Akira; Yamanaka, Takashi; Yamane, Fumiya; Yamatani, Masahiro; Yamazaki, Tomohiro; Yamazaki, Yuji; Yan, Zhen; Yang, Haijun; Yang, Hongtao; Yang, Siqi; Yang, Yi; Yang, Zongchang; Yao, Weiming; Yap, Yee Chinn; Yasu, Yoshiji; Yatsenko, Elena; Yau, Kaven; Ye, Jingbo; Ye, Shuwei; Yeletskikh, Ivan; Yigitbasi, Efe; Yildirim, Eda; Yorita, Kohei; Yoshihara, Keisuke; Young, Christopher John; Young, Charles; Yu, Jaehoon; Yu, Jie; Yuen, Stephanie Pui Yan; Bin Yusuff, Imran; Zabinski, Bartlomiej; Zacharis, George; Zaidan, Remi; Zaitsev, Alexander; Zakharchuk, Nataliia; Zalieckas, Justas; Zambito, Stefano; Zanzi, Daniele; Zeitnitz, Christian; Zemaityte, Gabija; Zeng, Jian Cong; Zeng, Qi; Zenin, Oleg; Zerwas, Dirk; Zhang, Dongliang; Zhang, Dengfeng; Zhang, Fangzhou; Zhang, Guangyi; Zhang, Huijun; Zhang, Jinlong; Zhang, Lei; Zhang, Liqing; Zhang, Matt; Zhang, Peng; Zhang, Ruiqi; Zhang, Rui; Zhang, Xueyao; Zhang, Yu; Zhang, Zhiqing; Zhao, Xiandong; Zhao, Yongke; Zhao, Zhengguo; Zhemchugov, Alexey; Zhou, Bing; Zhou, Chen; Zhou, Li; Zhou, Maosen; Zhou, Mingliang; Zhou, Ning; Zhou, You; Zhu, Cheng Guang; Zhu, Hongbo; Zhu, Junjie; Zhu, Yingchun; Zhuang, Xuai; Zhukov, Konstantin; Zhulanov, Vladimir; Zibell, Andre; Zieminska, Daria; Zimine, Nikolai; Zimmermann, Stephanie; Zinonos, Zinonas; Zinser, Markus; Ziolkowski, Michael; Zobernig, Georg; Zoccoli, Antonio; Zou, Rui; zur Nedden, Martin; Zwalinski, Lukasz

    2018-01-01

    Results of a search for gluino pair production with subsequent R-parity-violating decays to quarks are presented. This search uses 36.1 fb$^{-1}$ of data collected by the ATLAS detector in proton--proton collisions with a center-of-mass energy of $\\sqrt{s}$ = 13 TeV at the LHC. The analysis is performed using requirements on the number of jets and the number of jets tagged as containing a $b$-hadron as well as a topological observable formed by the scalar sum of masses of large-radius jets in the event. No significant excess above the expected Standard Model background is observed. Limits are set on the production of gluinos in models with the R-parity-violating decays of either the gluino itself (direct decay) or the neutralino produced in the R-parity-conserving gluino decay (cascade decay). In the gluino cascade decay model, gluinos with masses between 1000 GeV and 1875 GeV are excluded at 95\\% confidence level, depending on the neutralino mass. For the gluino direct decay model, the 95\\% confidence level...

  13. Transmutation in ADS and needs for nuclear data, with an introduction to the n-TOF at CERN

    CERN Document Server

    González, E; Fernández, R; García, J; Villamarín, D

    1999-01-01

    Transmutation can help in the nuclear waste problem by reducing seriously the life and amount of the most dangerous isotopes (radiotoxicity, heat, packing volume and neutron multiplication reductions). ADS are one of the best technologies for nuclear waste transmutation at large scale. Although enough information is available to prepare conceptual designs and make assessments on their performance, a large R&D campaign is required to obtain the precision data required to optimize the detailed engineering design and refine our expectations calculations on waste reduction by the different transmutation strategies being proposed. In particular a large R&D effort is required in nuclear physics, where fundamental differential measurements and integral verification experiments are required. In this sense, the PS213 n-TOF at CERN PS (at Switzerland) will become one of the largest installations to perform the fundamental differential measurements and a wide international collaboration has been setup to perform...

  14. User requirements for information systems in nuclear medicine.

    Science.gov (United States)

    Todd-Pokropek, A; Vauramo, E; Cosgriff, P; Sippo-Tujunen, I; Britton, K

    1992-05-01

    In the field of COST cooperation (COST = European Cooperation in the Field of Scientific and Technical Research) a project B2 for Quality Assurance in Nuclear Medicine Software has been established. In a memorandum of understanding setting up this project, user requirements were to be defined for the hardware and software used for data acquisition, processing and presentation. A subgroup of the management committee of COST B2 were interested in the Advanced Informatics in Medicine, AIM, task T-734 'Quality Assurance of Medical Software', and the AIM Project 'A 1034', coordinated by Dr K. Britton, was initiated. The initial drafts of this document were written in Helsinki during 1988-1990, and submitted for comment by the members of the management committee of COST B2. These comments were integrated in the text and this document was finalized by the UK group so as to make it available for international discussion. It is anticipated that, after appropriate international discussion, these User Requirements for Information Systems in Nuclear Medicine will be adopted by the management committee of COST B2 as a COST document. Towards these ends, a working group chaired by Dr Britton, including the British and Finnish teams and Ulrich Noelpp from Switzerland, was appointed by the management committee of COST B2 in April 1990. While writing it we have had the pleasure of working with referees from different European hospitals in many countries. We are happy to thank all of them for their valuable contributions.

  15. submitter The TORCH detector R&D: Status and perspectives

    CERN Document Server

    Gys, T; Castillo García, L; Cussans, D; Föhl, K; Forty, R; Frei, C; Gao, R; Harnew, N; Piedigrossi, D; Rademacker, J; Ros García, A; van Dijk, M

    2017-01-01

    TORCH (Timing Of internally Reflected CHerenkov photons) is a time-of-flight detector for particle identification at low momentum. It has been originally proposed for the LHCb experiment upgrade. TORCH is using plates of quartz radiator in a modular design. A fraction of the Cherenkov photons produced by charged particles passing through this radiator propagate by total internal reflection, they emerge at the edges and are subsequently focused onto fast, position-sensitive single-photon detectors. The recorded position and arrival time of the photons are used to precisely reconstruct their trajectory and propagation time in the quartz. The on-going R&D; programme aims at demonstrating the TORCH basic concept through the realization of a full detector module and has been organized on the following main development lines: micro-channel plate photon detectors featuring the required granularity and lifetime, dedicated fast front-end electronics preserving the picosecond timing information provided by single p...

  16. Statistics for library and information services a primer for using open source R software for accessibility and visualization

    CERN Document Server

    Friedman, Alon

    2016-01-01

    Statistics for Library and Information Services, written for non-statisticians, provides logical, user-friendly, and step-by-step instructions to make statistics more accessible for students and professionals in the field of Information Science. It emphasizes concepts of statistical theory and data collection methodologies, but also extends to the topics of visualization creation and display, so that the reader will be able to better conduct statistical analysis and communicate his/her findings. The book is tailored for information science students and professionals. It has specific examples of dataset sets, scripts, design modules, data repositories, homework assignments, and a glossary lexicon that matches the field of Information Science. The textbook provides a visual road map that is customized specifically for Information Science instructors, students, and professionals regarding statistics and visualization. Each chapter in the book includes full-color illustrations on how to use R for the statistical ...

  17. 20 CFR 669.660 - What planning documents and information are required in the application for MSFW youth grants and...

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What planning documents and information are... PROGRAM UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT The MSFW Youth Program § 669.660 What planning...? The required planning documents and other required information and the submission dates for filing are...

  18. Automata learning algorithms and processes for providing more complete systems requirements specification by scenario generation, CSP-based syntax-oriented model construction, and R2D2C system requirements transformation

    Science.gov (United States)

    Hinchey, Michael G. (Inventor); Margaria, Tiziana (Inventor); Rash, James L. (Inventor); Rouff, Christopher A. (Inventor); Steffen, Bernard (Inventor)

    2010-01-01

    Systems, methods and apparatus are provided through which in some embodiments, automata learning algorithms and techniques are implemented to generate a more complete set of scenarios for requirements based programming. More specifically, a CSP-based, syntax-oriented model construction, which requires the support of a theorem prover, is complemented by model extrapolation, via automata learning. This may support the systematic completion of the requirements, the nature of the requirement being partial, which provides focus on the most prominent scenarios. This may generalize requirement skeletons by extrapolation and may indicate by way of automatically generated traces where the requirement specification is too loose and additional information is required.

  19. Does Business Writing Require Information Literacy?

    Science.gov (United States)

    Katz, Irvin R.; Haras, Catherine; Blaszczynski, Carol

    2010-01-01

    Although the business community increasingly recognizes information literacy as central to its work, there remains the critical problem of measurement: How should employers assess the information literacy of their current or potential workers? In this article, we use a commercially available assessment to investigate the relationship between…

  20. A.C.R.O. activity report 2004; A.C.R.O. rapport d'activite 2004

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    The A.C.R.O. continues to play an indispensable role through both additional objectives which guide its activities: the environmental surveillance and the public information. In 2004, these objectives are translated by numerous actions which join the continuity of the orientations taken for several years, as for example the periodic publication of all the analysis results via our quarterly review and our www.acro.eu.org web site, but also our participation at commissions, working groups and groups of institutional experts or not. Year 2004 marks the beginning of our commitment in Belarus, country still strongly marked by the disaster of Chernobylsk, to work with the population of the contaminated territories. The project aims to set up a surveillance of the contamination at the inhabitants disposal and to promote the distribution of information and knowledge in radiological protection, essentially turned to the young people, the housewives and the pregnant women. The peculiarity of this project is to give the coordination to the inhabitants, so that they can pursue it in any autonomy. On the day before the 20. anniversary of the disaster, this commitment seems to us important and meaningful as the international community seems to have forgotten Chernobylsk; beyond the help which we can bring over there, we also have many things to be learnt to pass on and testify around us. As regards the environmental surveillance, the A.C.R.O. decided in 2004 to melt again its programs of surveillance and evaluation led on the scale of the big West to form only one. Key project of year 2004, the launch of the network citizen of the wakefulness, information and radioecological evaluation (R.I.V.I.E.R.E.) allows to understand the levels and the tendencies of the aquatic ecosystems radioactivity on the scale of the Seine Normandy pond: from Nogent-sur-Seine to La Hague and from the Mont-Saint-Michel to Penly. The peculiarity of this network, which also makes its strength, is to