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Sample records for atrophic corpus gastritis

  1. Features of the Atrophic Corpus Mucosa in Three Cases of Autoimmune Gastritis Revealed by Magnifying Endoscopy

    OpenAIRE

    Kazuyoshi Yagi; Atsuo Nakamura; Atsuo Sekine; David Graham

    2012-01-01

    Atrophic gastritis, whether caused by Helicobacter pylori infection or as a result of an autoimmune process, is associated with corpus atrophy. However, whereas atrophic gastritis caused by H. pylori involves the antrum, the antrum is spared in autoimmune gastritis. Here, we report the use of magnifying endoscopy to identify and distinguish atrophic gastritis caused by H. pylori from autoimmune gastritis. The mucosal pattern in autoimmune gastritis is that of closely arranged small round and ...

  2. Association of autoimmune type atrophic corpus gastritis with Helicobacter pylori infection

    Institute of Scientific and Technical Information of China (English)

    Lea; Irene; Veijola; Aino; Mirjam; Oksanen; Pentti; Ilmari; Sipponen; Hilpi; Iris; Kaarina; Rautelin

    2010-01-01

    AIM:To study the association between Helicobacter pylori(H.pylori)infection and autoimmune type atrophic gastritis. METHODS:Twenty-three patients with different grades of atrophic gastritis were analysed using enzyme immunoassay-based serology,immunoblot-based serology,and histology to reveal a past or a present H.pylori infection.In addition,serum markers for gastric atrophy(pepsinogenⅠ,pepsinogenⅠ/Ⅱand gastrin)and autoimmunity[parietal cell antibodies(PCA), and intrinsic factor(IF),antibodies]were determi...

  3. Atrophic gastritis in young children and adolescents

    OpenAIRE

    Ricuarte, O; Gutierrez, O.; Cardona, H; Kim, J. G.; Graham, D Y; El-Zimaity, H M T

    2005-01-01

    Background: Helicobacter pylori associated gastric cancer arises via a multistage process, with atrophic gastritis being the precursor lesion. Helicobacter pylori is typically acquired in childhood, yet little is known of the prevalence of atrophic gastritis in childhood.

  4. Atrophic gastritis and Helicobacter pylori infection in outpatients referred for gastroscopy

    OpenAIRE

    Oksanen, A.; Sipponen, P; Karttunen, R.; Miettinen, A.; Veijola, L; S. Sarna; Rautelin, H

    2000-01-01

    BACKGROUND—Atrophic gastritis has been shown to be one of the long term sequelae of Helicobacter pylori infection.
AIMS—To determine the prevalence of atrophic gastritis in outpatients, to study the accuracy of serological methods for revealing atrophy, and to define the association of H pylori infection with atrophic gastritis in these patients.
PATIENTS/METHODS—A total of 207 consecutive outpatients referred for gastroscopy were included. Biopsy specimens from the antrum and corpus were ass...

  5. Extensive Atrophic Gastritis Increases Intraduodenal Hydrogen Gas

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    Kazumasa Miki

    2008-06-01

    Full Text Available Objective. Gastric acid plays an important part in the prevention of bacterial colonization of the gastrointestinal tract. If these bacteria have an ability of hydrogen (H2 fermentation, intraluminal H2 gas might be detected. We attempted to measure the intraluminal H2 concentrations to determine the bacterial overgrowth in the gastrointestinal tract. Patients and methods. Studies were performed in 647 consecutive patients undergoing upper endoscopy. At the time of endoscopic examination, we intubated the stomach and the descending part of the duodenum without inflation by air, and 20 mL of intraluminal gas samples of both sites was collected through the biopsy channel. Intraluminal H2 concentrations were measured by gas chromatography. Results. Intragastric and intraduodenal H2 gas was detected in 566 (87.5% and 524 (81.0% patients, respectively. The mean values of intragastric and intraduodenal H2 gas were 8.5±15.9 and 13.2±58.0 ppm, respectively. The intraduodenal H2 level was increased with the progression of atrophic gastritis, whereas the intragastric H2 level was the highest in patients without atrophic gastritis. Conclusions. The intraduodenal hydrogen levels were increased with the progression of atrophic gastritis. It is likely that the influence of hypochlorhydria on bacterial overgrowth in the proximal small intestine is more pronounced, compared to that in the stomach.

  6. How to assess the severity of atrophic gastritis

    Institute of Scientific and Technical Information of China (English)

    Yan-Cheng Dai; Zhi-Peng Tang; Ya-Li Zhang

    2011-01-01

    Atrophic gastritis, is the main consequence of long-standing Helicobacter pylori infection, and is linked to the development of gastric cancer. The severity of atrophic gastritis is related to the lifetime risk of gastric cancer development, especially in terms of its degree and extent of mucosal damage. Therefore, it is important for clinicians to assess the severity of atrophic gastritis, interfere with the disease progress, and reverse gastric mucosal atrophy. In the article, we demonstrated some methods (conventional endoscopy, modern endoscopic technology and noninvasive methods) that may help assess the severity of atrophic gastritis and select the reasonable treatment protocols.

  7. Corpus gastritis is protective against reflux oesophagitis

    OpenAIRE

    El-Serag, H; Sonnenberg, A.; Jamal, M.; Inadomi, J; Crooks, L.; Feddersen, R

    1999-01-01

    BACKGROUND—Gastric acid is important in the pathogenesis of reflux oesophagitis. Acid production by the gastric corpus is reduced in corpus gastritis.
AIMS—To determine whether corpus gastritis protects against reflux oesophagitis.
METHODS—Patients presenting for elective oesophagogastroduodenoscopy were studied. Two biopsy specimens were taken from the antrum, corpus, and cardia and stained with haematoxylin/eosin and Diff-Quick II stains. The presence and severity of gastritis were graded a...

  8. The Efect of Helicobacter Pylori Eradication on Atrophic Gastritis and Intestinal metaplasia

    OpenAIRE

    Guldem Kilciler

    2011-01-01

     Aim: The aim of this prospective study was to evaluate whether helicobacter pylori eradication could improve gastric atropy or intestinal metaplasia. Material and Method: Forty-two pylori infected patients were evaluated for the status of atrophic gastritis and intestinal metaplasia. Two biopsy specimens from antrum and two biopsy specimens from corpus were taken before and 6 months after the helicobacter pylori eradication therapy. Helicobacter pylori status was determined by C-urea br...

  9. Chronic atrophic gastritis in association with hair mercury level.

    Science.gov (United States)

    Xue, Zeyun; Xue, Huiping; Jiang, Jianlan; Lin, Bing; Zeng, Si; Huang, Xiaoyun; An, Jianfu

    2014-11-01

    The objective of this study was to explore hair mercury level in association with chronic atrophic gastritis, a precancerous stage of gastric cancer (GC), and thus provide a brand new angle of view on the timely intervention of precancerous stage of GC. We recruited 149 healthy volunteers as controls and 152 patients suffering from chronic gastritis as cases. The controls denied upper gastrointestinal discomforts, and the cases were diagnosed as chronic superficial gastritis (n=68) or chronic atrophic gastritis (n=84). We utilized Mercury Automated Analyzer (NIC MA-3000) to detect hair mercury level of both healthy controls and cases of chronic gastritis. The statistic of measurement data was expressed as mean ± standard deviation, which was analyzed using Levene variance equality test and t test. Pearson correlation analysis was employed to determine associated factors affecting hair mercury levels, and multiple stepwise regression analysis was performed to deduce regression equations. Statistical significance is considered if p value is less than 0.05. The overall hair mercury level was 0.908949 ± 0.8844490 ng/g [mean ± standard deviation (SD)] in gastritis cases and 0.460198 ± 0.2712187 ng/g (mean±SD) in healthy controls; the former level was significantly higher than the latter one (p=0.000healthy controls (phealthy controls (phealthy controls with eating seafood was significantly higher than that in healthy controls without eating seafood (peating seafood was most correlated with hair mercury level and positively correlated in the healthy controls and that the severity of gastritis was most correlated with hair mercury level and positively correlated in the gastritis cases. Multiple stepwise regression analysis indicated that the regression equation of hair mercury level in controls could be expressed as 0.262 multiplied the value of eating seafood plus 0.434, the model that was statistically significant (pfactor affecting the hair mercury level is eating

  10. Prof.Shan Zhaowei's Experience in Treating Chronic Atrophic Gastritis

    Institute of Scientific and Technical Information of China (English)

    吴连恩; 杨建平

    2004-01-01

    @@ Having been engaged in clinical practice for 40 years,Prof. Shah Zhaowei of Jiangsu Provincial Hospital of Traditional Chinese Medicine is good at treating chronic atrophic gastritis (CAG). In clinical practice,he often pays great attention to the combination of TCM syndrome-differentiation with diseasedifferentiation as well as the combination of macroscopic differentiation with microscopic differentiation. The therapeutic method he adopts or the drugs he prescribes are both simple and clear,often leading to remarkably therapeutic results. The following is a brief introduction to his clinical experience on the treatment of chronic atrophic gastritis (CAG).

  11. Relationship between gastrin cell number, serum, antral mucosa and luminal gastrin concentration and gastric acidity in antral atrophic gastritis.

    OpenAIRE

    Marotta, F; Hayakawa, K.; Mikami, Y.; Morello, P; Sugai, M; Morita, T

    1990-01-01

    The aim of our study was to investigate the relationship between gastrin producing cell density with antral mucosa, luminal and serum gastrin concentration in antral atrophic gastritis. Our study group consisted of 17 patients: six with mild atrophic gastritis, seven with moderate atrophic gastritis and four with severe atrophic gastritis. None of the patients had type-A atrophic gastritis but the body mucosa was affected by superficial gastritis at various extent in some. A group of 15 healt...

  12. Correlations Among Endoscopic, Histologic and Serologic Diagnoses for the Assessment of Atrophic Gastritis

    OpenAIRE

    Lee, Ju Yup; Kim, Nayoung; Lee, Hye Seung; Oh, Jane C.; Kwon, Yong Hwan; Choi, Yoon Jin; Yoon, Ki Chul; Hwang, Jae Jin; Lee, Hyun Joo; Lee, AeRa; Jeong, Yeonsang; Jo, Hyun Jin; Yoon, Hyuk; Shin, Cheol Min; Park, Young Soo

    2014-01-01

    Background: Atrophic gastritis is a precancerous condition, which can be diagnosed by several methods. However, there is no consensus for the standard method. The aim of this study was to evaluate the correlations among endoscopic, histologic, and serologic findings for the diagnosis of atrophic gastritis. Methods: From March 2003 to August 2013, a total of 2,558 subjects were enrolled. Endoscopic atrophic gastritis was graded by Kimura-Takemoto classification and histological atrophic gastri...

  13. Serum Prohepcidin Levels Are Lower in Patients with Atrophic Gastritis

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    Hyung-Keun Kim

    2013-01-01

    Full Text Available Background/Aim. Hepcidin, an iron regulatory hormone, is increased in response to inflammation and some infections. We investigated the relationships among serum prohepcidin, iron status, Helicobacter pylori infection status, and the presence of gastric mucosal atrophy. Methods. Seventy subjects undergoing esophagogastroduodenoscopy underwent multiple gastric biopsies, and the possibility of H. pylori infection and the degree of endoscopic and histologic gastritis were investigated. In all subjects, serum prohepcidin and iron parameters were evaluated. Results. No correlations were observed between serum prohepcidin levels and the other markers of anemia, such as hemoglobin, serum iron, ferritin, and total iron binding capacity. Serum prohepcidin levels were not significantly different between the H. pylori-positive group and the H. pylori-negative group. Serum prohepcidin levels in atrophic gastritis patients were significantly lower than those in subjects without atrophic gastritis irrespective of H. pylori infection. Conclusion. Serum prohepcidin levels were not altered by H. pylori infection. Serum prohepcidin levels decrease in patients with atrophic gastritis, irrespective of H. pylori infection. It suggests that hepcidin may decrease due to gastric atrophy, a condition that causes a loss of hepcidin-producing parietal cells. Further investigations with a larger number of patients are necessary to substantiate this point.

  14. The Prevalence of Helicobacter pylori Infection Decreases with Older Age in Atrophic Gastritis

    OpenAIRE

    Shaohua Chen; Lixiong Ying; Mei Kong; Yu Zhang; Youming Li

    2013-01-01

    The clinical pathological characteristics of 3969 adult patients with chronic atrophic gastritis were retrospectively studied. The positivity of intestinal metaplasia and dysplasia in atrophic gastric specimens increased with age; however, H. pylori positivity and inflammatory activity decreased significantly with increased age. H. pylori infection was present in 21.01% of chronic atrophic gastritis patients, and 92.33% of the subjects with H. pylori infection were found to have simultaneous ...

  15. Protective Action of Acupuncture and Moxibustion on Gastric Mucosa in Model Rats with Chronic Atrophic Gastritis

    Institute of Scientific and Technical Information of China (English)

    高希言; 饶红; 王燕; 孟丹; 魏玉龙

    2005-01-01

    Objective: To probe the mechanism of acupuncture and moxibustion in atrophic gastritis so as to provide a basis for clinical treatment. Method: Observe the effects of acupuncture and moxibustion at the points of Zusanli, Zhongwan and Tianshu on gastric mucosa in model rats with chronic atrophic gastritis. Results:Acupuncture and moxibustion can increase the contents of PGE2α, PGF2α and cAMP, and decrease the content of cGMP in the tissue of gastric mucosa. Conclusion: Acupuncture and moxibustion shows cytoprotection on gastric mucosa, so it is an effective method for treating chronic atrophic gastritis.

  16. Risk factors for atrophic chronic gastritis in a European population: results of the Eurohepygast study

    OpenAIRE

    2002-01-01

    Background and aims: The development of atrophic chronic gastritis (ACG) is multifactorial, involving environment as well as host responses to Helicobacter pylori infection. The aim of this study was to determine factors involved in ACG in a European dyspeptic population.

  17. Inflammatory cytokine gene polymorphisms increase the risk of atrophic gastritis and intestinal metaplasia

    OpenAIRE

    Li, Zhong-Wu; Wu, Ying; SUN, YU; LIU, LU-YING; Tian, Meng-Meng; Feng, Guo-Shuang; You, Wei-cheng; Li, Ji-You

    2010-01-01

    AIM: To investigate the effects of interleukin-8 (IL-8), macrophage migration inhibitory factor (MIF) gene polymorphisms, Helicobacter pylori (H. pylori) infection, on the risk of developing severe chronic atrophic gastritis (SCAG) and intestinal metaplasia (IM).

  18. The Diagnostic Value of Gastrin-17 Detection in Atrophic Gastritis

    Science.gov (United States)

    Wang, Xu; Ling, Li; Li, Shanshan; Qin, Guiping; Cui, Wei; Li, Xiang; Ni, Hong

    2016-01-01

    Abstract A meta-analysis was performed to assess the diagnostic value of gastrin-17 (G-17) for the early detection of chronic atrophic gastritis (CAG). An extensive literature search was performed, with the aim of selecting publications that reported the accuracy of G-17 in predicting CAG, in the following databases: PubMed, Science Direct, Web of Science, Chinese Biological Medicine, Chinese National Knowledge Infrastructure, Wanfang, and VIP. To assess the diagnostic value of G-17, the following statistics were estimated and described: sensitivity, specificity, diagnostic odds ratios (DOR), summary receiver operating characteristic curves, area under the curve (AUC), and 95% confidence intervals (CIs). Thirteen studies that met the inclusion criteria were included in this meta-analysis, comprising 894 patients and 1950 controls. The pooled sensitivity and specificity of these studies were 0.48 (95% CI: 0.45–0.51) and 0.79 (95% CI: 0.77–0.81), respectively. The DOR was 5.93 (95% CI: 2.93–11.99), and the AUC was 0.82. G-17 may have potential diagnostic value because it has good specificity and a moderate DOR and AUC for CAG. However, more studies are needed to improve the sensitivity of this diagnostic tool in the future. PMID:27149493

  19. Comparative proteomics analysis of chronic atrophic gastritis: changes of protein expression in chronic atrophic gastritis without Helicobacter pylori infection

    Directory of Open Access Journals (Sweden)

    Lin Zhang

    2012-03-01

    Full Text Available Chronic atrophic gastritis (CAG is a very common gastritis and one of the major precursor lesions of gastric cancer, one of the most common cancers worldwide. The molecular mechanism underlying CAG is unclear, but its elucidation is essential for the prevention and early detection of gastric cancer and appropriate intervention. A combination of two-dimensional gel electrophoresis and mass spectrometry was used in the present study to analyze the differentially expressed proteins. Samples from 21 patients (9 females and 12 males; mean age: 61.8 years were used. We identified 18 differentially expressed proteins in CAG compared with matched normal mucosa. Eight proteins were up-regulated and 10 down-regulated in CAG when compared with the same amounts of proteins in individually matched normal gastric mucosa. Two novel proteins, proteasome activator subunit 1 (PSME1, which was down-regulated in CAG, and ribosomal protein S12 (RPS12, which was up-regulated in CAG, were further investigated. Their expression was validated by Western blot and RT-PCR in 15 CAG samples matched with normal mucosa. The expression level of RPS12 was significantly higher in CAG than in matched normal gastric mucosa (P < 0.05. In contrast, the expression level of PSME1 in CAG was significantly lower than in matched normal gastric mucosa (P < 0.05. This study clearly demonstrated that there are some changes in protein expression between CAG and normal mucosa. In these changes, down-regulation of PSME1 and up-regulation of RPS12 could be involved in the development of CAG. Thus, the differentially expressed proteins might play important roles in CAG as functional molecules.

  20. Comparative proteomics analysis of chronic atrophic gastritis: changes of protein expression in chronic atrophic gastritis with out Helicobacter pylori infection

    International Nuclear Information System (INIS)

    Chronic atrophic gastritis (CAG) is a very common gastritis and one of the major precursor lesions of gastric cancer, one of the most common cancers worldwide. The molecular mechanism underlying CAG is unclear, but its elucidation is essential for the prevention and early detection of gastric cancer and appropriate intervention. A combination of two-dimensional gel electrophoresis and mass spectrometry was used in the present study to analyze the differentially expressed proteins. Samples from 21 patients (9 females and 12 males; mean age: 61.8 years) were used. We identified 18 differentially expressed proteins in CAG compared with matched normal mucosa. Eight proteins were up-regulated and 10 down-regulated in CAG when compared with the same amounts of proteins in individually matched normal gastric mucosa. Two novel proteins, proteasome activator subunit 1 (PSME1), which was down-regulated in CAG, and ribosomal protein S12 (RPS12), which was up-regulated in CAG, were further investigated. Their expression was validated by Western blot and RT-PCR in 15 CAG samples matched with normal mucosa. The expression level of RPS12 was significantly higher in CAG than in matched normal gastric mucosa (P < 0.05). In contrast, the expression level of PSME1 in CAG was significantly lower than in matched normal gastric mucosa (P < 0.05). This study clearly demonstrated that there are some changes in protein expression between CAG and normal mucosa. In these changes, down-regulation of PSME1 and up-regulation of RPS12 could be involved in the development of CAG. Thus, the differentially expressed proteins might play important roles in CAG as functional molecules

  1. Comparative proteomics analysis of chronic atrophic gastritis: changes of protein expression in chronic atrophic gastritis with out Helicobacter pylori infection

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Lin; Hou, Yanhong; Wu, Kai; Li, Dan [Department of Gastroenterology and Hepatology, The 309 Hospital of People' s Liberation Army, Beijing (China)

    2012-03-02

    Chronic atrophic gastritis (CAG) is a very common gastritis and one of the major precursor lesions of gastric cancer, one of the most common cancers worldwide. The molecular mechanism underlying CAG is unclear, but its elucidation is essential for the prevention and early detection of gastric cancer and appropriate intervention. A combination of two-dimensional gel electrophoresis and mass spectrometry was used in the present study to analyze the differentially expressed proteins. Samples from 21 patients (9 females and 12 males; mean age: 61.8 years) were used. We identified 18 differentially expressed proteins in CAG compared with matched normal mucosa. Eight proteins were up-regulated and 10 down-regulated in CAG when compared with the same amounts of proteins in individually matched normal gastric mucosa. Two novel proteins, proteasome activator subunit 1 (PSME1), which was down-regulated in CAG, and ribosomal protein S12 (RPS12), which was up-regulated in CAG, were further investigated. Their expression was validated by Western blot and RT-PCR in 15 CAG samples matched with normal mucosa. The expression level of RPS12 was significantly higher in CAG than in matched normal gastric mucosa (P < 0.05). In contrast, the expression level of PSME1 in CAG was significantly lower than in matched normal gastric mucosa (P < 0.05). This study clearly demonstrated that there are some changes in protein expression between CAG and normal mucosa. In these changes, down-regulation of PSME1 and up-regulation of RPS12 could be involved in the development of CAG. Thus, the differentially expressed proteins might play important roles in CAG as functional molecules.

  2. The Prevalence of Helicobacter pylori Infection Decreases with Older Age in Atrophic Gastritis

    Directory of Open Access Journals (Sweden)

    Shaohua Chen

    2013-01-01

    Full Text Available The clinical pathological characteristics of 3969 adult patients with chronic atrophic gastritis were retrospectively studied. The positivity of intestinal metaplasia and dysplasia in atrophic gastric specimens increased with age; however, H. pylori positivity and inflammatory activity decreased significantly with increased age. H. pylori infection was present in 21.01% of chronic atrophic gastritis patients, and 92.33% of the subjects with H. pylori infection were found to have simultaneous inflammatory activity. The intestinal metaplasia and dysplasia positivity markedly increased as the degree of gastric atrophy increased. In conclusion, the incidence of H. pylori infection decreased with age and correlated significantly with inflammatory activity in atrophic gastritis patients. The intestinal metaplasia and dysplasia positivity notably increased as the degree of gastric atrophy increased. Large population-based prospective studies are needed to better understand the progression of CAG.

  3. HOGG1 polymorphism in atrophic gastritis and gastric cancer after Helicobacter pylori eradication

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    AIM:To investigate the association between Ser326Cys human oxoguanine glycosylase 1(hOGG1) polymorphism and atrophic gastritis and gastric cancer after Helicobacter pylori(H.pylori) eradication.METHODS:A total of 488 subjects(73 patients with gastric cancer,160 with atrophic gastritis after H.pylori eradication and 255 controls) were prospectively collected.Polymerase chain reaction-restriction fragment length polymorphism analysis was performed to distinguish hOGG1 Ser326Cys polymorphism.Statistical analys...

  4. Inflammatory cytokine gene polymorphisms increase the risk of atrophic gastritis and intestinal metaplasia

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    AIM: To investigate the effects of interleukin-8 (IL-8 ), macrophage migration inhibitory factor (MIF ) gene polymorphisms, Helicobacter pylori (H. pylori ) infection, on the risk of developing severe chronic atrophic gastritis (SCAG) and intestinal metaplasia (IM). METHODS: A total of 372 cases were selected from a cohort study in Linqu County, a high risk area for gastric cancer (GC) in northern China. To obtain a sufficient group size, patients with normal or superficial gastritis were included. Based on...

  5. Influence of H pylori on plasma ghrelin in patients without atrophic gastritis

    Institute of Scientific and Technical Information of China (English)

    Mehmet Cindoruk; Ilhan Yetkin; Serpil Muge Deger; Tarkan Karakan; Erdal Kan; Selahattin Unal

    2007-01-01

    AIM: To determine the association between H pylori infection and serum ghrelin levels in patients without atrophic gastritis.METHODS: Fifty consecutive patients (24 males and 26 females) with either H pylori-positive gastritis (n = 34) or H pylori-negative gastritis (n = 16) with normal gastric acid secretion determined by 24-h pHmetry and without atrophic gastritis in histopathology were enrolled in this study. Thirty-four H pylori-infected patients were treated with triple therapy consisting of a daily regimen of 30 mg lansoprazole bid, 1 g amoxicillin bid and 500 mg clarithromycin bid for 14 d, followed by an additional 4 wk of 30 mg lansoprazol treatment. H pylori infection was eradicated in 23 of 34 (67.6%) patients. H pylori-positive patients were given eradication therapy. Gastric acidity was determined via intragastric pH catethers. Serum ghrelin was measured by radioimmunoassay (RIA).RESULTS: There was no significant difference in plasma ghrelin levels between H pylori -positive and H pylori-negative groups (81.10 ± 162.66 ng/L vs 76.51 ± 122.94 ng/L). In addition, there was no significant difference in plasma ghrelin levels and gastric acidity levels measured before and 3 mo after the eradication therapy.CONCLUSION: H pylori infection does not influence ghrelin secretion in patients with chronic gastritis without atrophic gastritis.

  6. PREVALENCE OF HELICOBACTER PYLORI INFECTION IN PATIENTS WITH ATROPHIC GASTRITIS AND ROLE OF DARK FIELD MICROSCOPY IN DIAGNOSIS

    OpenAIRE

    Ananthamurugan; Saleem; Gopal; Sunil Shivekar; Kaviraj; Balamurugan

    2015-01-01

    BACKGROUND: Helicobacter pylori is the most common human pathogen which causes chronic gastritis, leading to serious complications. The aim was to study the incidence of H. pylori infection and the risk factors associated with chronic atrophic gastritis using simple diagnostic procedures. MATERIALS AND METHODS: Biopsy samples were collected from 146 chronic atrophic gastritis patients. Rapid Urease Test (RUT) and dark field microscopy were used to diagnose the presence of H. p...

  7. 3H-TdR autoradiography in vitro incubation for the evaluation of the therapeutic effect in chronic atrophic gastritis

    International Nuclear Information System (INIS)

    This paper discussed with the feasibility of using 3H-TdR autoraoiography in vitro incubation to evaluate the therapeutic effect of atrophic gastritis. The results showed that gastric mucosa labelling indices measured by autoradiography can reflect the property, severity and clincal conditions of chronic gastritis quantitatively. The methodology is raliable and reproducible. It was suggested that labelling indices may serve as a cytokinetic parameter to evaluate the therapeutic effect of atrophic gastritis

  8. Clinical Research on Acupuncture and Moxibustion Treatment of Chronic Atrophic Gastritis

    Institute of Scientific and Technical Information of China (English)

    Gao Xiyan; Yuan Jing; Li Huijuan; Ren Shan

    2007-01-01

    Objective: To observe the clinical therapeutic effects of acupuncture and moxibustion in treating chronic atrophic gastritis. Methods: Patients who met the criteria were randomly divided into the treatment groups consisting of the acupuncture group (30 cases) and the acupuncture-moxibustion group (30 cases), and the control group (28 cases). After two months of treatment, observed were safety and the curative effects,through general physical check ups, routine examinations of blood, urine and feces, and symptoms,pathology and gastrin before, during and after the treatment. Results: 1) The treatment groups showed significant superiorities in the improvement of symptoms, with the acupuncture-moxibustion group showing the best therapeutic effects. 2) The acupuncture-moxibustion group showed marked differences before and after the treatment in the improvement of glandular atrophy and intestinal metaplasia, with a total effective rate of 66.67%. 3) After the treatment, the three groups all showed marked improvement in the level of serum gastrin, with the acupuncture-moxibustion group showing the best effects. Conclusion: Acupuncture and moxibustion have definite therapeutic effects for chronic atrophic gastritis, especially in improving the symptoms. Acupuncture or acupuncture combined with moxibustion can provide possibilities in reversing the pathologic changes of glandular atrophy and intestinal metaplasia for patients with chronic atrophic gastritis. Acupuncture-moxibustion is really an effective and safe therapy for chronic atrophic gastritis.

  9. Protective effects of heat shock protein70 induced by geranyl-geranylacetone in atrophic gastritis in rats

    Institute of Scientific and Technical Information of China (English)

    Wei-li LIU; Shu-jie CHEN; Yan CHEN; Lei-min SUN; Wei ZHANG; Ya-min ZENG; Tian-hua ZHOU; Jian-min SI

    2007-01-01

    Aim: To investigate the effect of geranylgeranylacetone (GGA) on the progres-sion of atrophic gastritis in rats and its potential mechanism. Methods: Atrophic gastritis was induced in Sprague-Dawley rats with 0.1% ammonia solution, 60% ethanol, and 20 mmol/L deoxycholic acid for 24 weeks. Accompanied by the induction of atrophic gastritis, 200 mg/kg GGA was administered by oral gavage for 8 weeks (weeks 17-24). The histological changes in gastric mucosa were quantitated by the index of inflammation, the gastric mucosal thickness, and the amount of glands of 1 mm horizontal length in antrum. Endogenous heat shock protein (HSP)70 levels and distribution were determined by immunoblotting and immunohistochemistry in gastric mucosa. Results: GGA alleviated the pathologi-cal progression of atrophic gastritis with inflammation relief (inflammation index: 1.40 in the GGA group and 1.65 in the atrophic gastritis group) and glandular restoration (rnucosal thickness and quantity of glands: 194.3 μm and 38.7 mm in the GGA group; 123.3 μm and 32.7 mm in the atrophic gastritis group; P<0.05). GGA significantly induced HSP70 synthesis (P<0.05). Moreover, quercetin, an inhibitor of HSP70 expression, aggravated the infiltration of inflammatory cells and glandular loss in the antrum. Conclusion: GGA prevented the progression of atrophic gastritis in rats via the induction of HSP70 expression.

  10. Expression of AQP3 gene in chronic atrophic and chronic superficial gastritis patients

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    Shijun Zhang

    2007-12-01

    Full Text Available BACKGROUND: Most studies about aquaporin 3 (AQP3 in the gastrointestinal tract were carried out on both in vivo and in vitro. The role of AQP3-mediated water transport in human gastrointestinal tract is still unclear. Our aim in this study was to explore the expression of AQP3 gene in chronic atrophic gastritis (CAG and chronic superficial gastritis (CSG atients and to determine its possible function in the development of gastritis.
    METHODS: Twenty-two outpatients diagnosed as CSG and 12 outpatients diagnosed as CAG were selected randomly. Ten cases of healthy individuals were selected as normal control group. In all cases, AQP3 gene expression of gastric mucosa was detected by fluorescence quantitative polymerase chain reaction (FQ-PCR.
    RESULTS: The AQP3 gene expression was significantly higher in gastric mucosa of CSG and healthy individuals than that in CAG (P<0.01. However, there was no significant difference in the AQP3 gene expression between helicobacter pylori positive patients and helicobacter pylori negative patients (P>0.05.
    CONCLUSIONS: AQP3 expression might play certain role in the occurrence and development of gastritis.
    KEY WORDS: Aquaporin 3, chronic superficial gastritis, chronic atrophic gastritis.

  11. Comparative examinations of serum pepsinogen I, II and gastric area using computed radiography in the atrophic gastritis

    Energy Technology Data Exchange (ETDEWEB)

    Tatsu, Yoshimitsu; Ogura, Yasuharu; Yamazaki, Kouichi [Osaka Medical Coll., Takatsuki (Japan)] [and others

    1995-11-01

    The relationship between serum PG I, PG II levels and extent of atrophic gastritis was examined. The subjects were 64 patients (male: 32, female: 32, 51.9 years old on average) with established diagnosis of either atrophic gastritis or normal. In the X-ray gastric examination, Fuji Computed Radiography (FCR) was used to obtain clear-cut images of the gastric area. Concerning the serum PG I level, patients in the group with atrophic gastritis showed lower levels than those of the people in the group with no atrophic change, but the variation was wide, and no definite tendency was seen in the relationship between the atrophic change and the serum PG I levels. Concerning the serum PG II level, as the atrophic change progresses, the serum PG II level tended to increase gradually. A significant reduction in the PG I/II ratio was seen in the group with atrophic changes (p<0.01) in comparison with the group with no atrophic changes, and the PG I/II value tended to decrease. In conclusion, as a relationship between the atrophic change and the serum PG levels had a wide variation, we considered it to be difficult to understand the presence and extent of the atrophic gastritis by measuring serum PG levels. (author).

  12. Comparative examinations of serum pepsinogen I, II and gastric area using computed radiography in the atrophic gastritis

    International Nuclear Information System (INIS)

    The relationship between serum PG I, PG II levels and extent of atrophic gastritis was examined. The subjects were 64 patients (male: 32, female: 32, 51.9 years old on average) with established diagnosis of either atrophic gastritis or normal. In the X-ray gastric examination, Fuji Computed Radiography (FCR) was used to obtain clear-cut images of the gastric area. Concerning the serum PG I level, patients in the group with atrophic gastritis showed lower levels than those of the people in the group with no atrophic change, but the variation was wide, and no definite tendency was seen in the relationship between the atrophic change and the serum PG I levels. Concerning the serum PG II level, as the atrophic change progresses, the serum PG II level tended to increase gradually. A significant reduction in the PG I/II ratio was seen in the group with atrophic changes (p<0.01) in comparison with the group with no atrophic changes, and the PG I/II value tended to decrease. In conclusion, as a relationship between the atrophic change and the serum PG levels had a wide variation, we considered it to be difficult to understand the presence and extent of the atrophic gastritis by measuring serum PG levels. (author)

  13. Lack of specific association between gastric autoimmunity hallmarks and clinical presentations of atrophic body gastritis

    Institute of Scientific and Technical Information of China (English)

    Bruno Annibale; Edith Lahner; Riccardo Negrini; Flavia Baccini; Cesare Bordi; Bruno Monarca; Gianfranco Delle Fave

    2005-01-01

    AIM: To investigate the possible relationships between gastric autoimmune phenomena and clinical presentations of this disorder, in consecutive atrophic body gastritis patients.METHODS: A total of 140 atrophic body gastritis patients,diagnosed as consecutive outpatients presenting with macrocytic or iron deficiency anemia, or longstanding dyspepsia underwent gastroscopy with antral and body biopsies, assay of intrinsic factor, parietal cells and Helicobacter pylori(H pylori) antibodies. Gastritis was assessed according to Sydney System.RESULTS: Parietal cell antibodies were equally distributed in all clinical presentations, whereas the positivity of intrinsic factor antibodies (49/140, 35%) was significantly higher in pernicious anemia patients (49.2%) than in iron deficiency (21.1%) and dyspeptic patients (27.8%). No specific pattern of autoantibodies was related to the clinical presentations of atrophic body gastritis. A positive correlation was obtained between the body atrophy score and the intrinsic factor antibody levels (r = 0.2216,P = 0.0085). Associated autoimmune diseases were present in 25/140 (17.9%) patients, but the prevalence of autoimmune diseases was comparable, irrespective of the clinical presentations.CONCLUSION: The so-called hallmarks of gastric autoimmunity, particularly in intrinsic factor antibody cannot be usefully employed in defining an autoimmune pattern in the clinical presentations of ABG.

  14. Upregulation of cathepsin W-expressing T cells is specific for autoimmune atrophic gastritis compared to other types of chronic gastritis

    Institute of Scientific and Technical Information of China (English)

    Doerthe Kuester; Michael Vieth; Ulrich Peitz; Stefan Kahl; Manfred Stolte; Albert Roessner; Ekkehard Weber; Peter Malfertheiner; Thomas Wex

    2005-01-01

    AIM: To investigate a pathophysiological role of cathepsin W (CatW), a putative thiol-dependent cysteine protease,which is specifically expressed in cytotoxic lymphocytes,in different types of chronic inflammation of the gastric mucosa.METHODS: Gastric and duodenal biopsies of patients with Helicobacter pylori ( H pylori)-associated active gastritis ( Hp,n = 19), chemically induced reactive gastritis (CG, n = 17),autoimmune atrophic gastritis (AIG, n = 20), lymphocytic corpus gastritis (LG, n = 29), celiac disease (CD, n = 10),and corresponding controls (n = 24) were analyzed by immunohistochemistry for the expression of CatW and CD45. Furthermore, immunohistochemical double staining with anti-CD3 and anti-cathepsin was performed for the samples of AIG.RESULTS: Median values of CatW-expressing cells among CD45-positive immune cells were between 2% and 6% for normal gastric mucosa, CG, and LG, whereas the corresponding value was significantly increased for AIG (24.7%, P<0.001) and significantly decreased for HP (0.7%, P<0.05). Double staining with anti-CD3 and antiCatW antibodies revealed that >90% of CatW-expressing cells in gastric mucosa of AIG were T cells. Duodenal mucosa had significantly more CatW/CD45-positive cells than normal gastric mucosa (median: 17.8% vs 2%, P<0.01).The corresponding proportion of CatW/CD45-positive cells was decreased in CD compared to duodenal mucosa (median: 2.1% vs 17.8%, P<0.05).CONCLUSION: The opposite findings regarding the presence of CatW-positive cells in AIG (increase) and CD (decrease) reflects the different cellular composition of immune cells involved in the pathogenesis of these diseases.

  15. Efficacy of tepronone and folic acid in the treatment of chronic atrophic gastritis evaluated by the marking targeting biopsy

    Institute of Scientific and Technical Information of China (English)

    裘力锋

    2013-01-01

    Objective To explore the efficacy of tepronone and folic acid in the treatment of chronic atrophic gastritis(CAG) evaluated by the marking targeting biopsy(MTB).Methods A total of 224 H.pylori negative

  16. The seroepidemiology of helicobacter pylori and its relationship to chronic atrophic gastritis

    OpenAIRE

    Sitas, Frederick.; Forman, David; Dr. David Forman

    1990-01-01

    There were three main aims to this thesis: 1. to test whether infection with Helicobacter pylori was related specifically to chronic atrophic gastritis (CAG), a precursor of gastric cancer; and to measure the specificity and sensitivity of Helicobacter pylori antibody markers for detecting H.pylori infection of the gastric mucosa; and CAG; 2. to measure the distribution of H.pylori in relation to sociodemographic, dietary and lifestyle characteristics in non-clinical ...

  17. An Unusual Presentation of Pseudothrombotic Microangiopathy in a Patient with Autoimmune Atrophic Gastritis

    Directory of Open Access Journals (Sweden)

    Alexandre Malek

    2016-01-01

    Full Text Available Introduction. We hereby describe the case of a young female patient who presented with pseudothrombotic microangiopathy, as well as pancytopenia accompanied by autoimmune atrophic gastritis. Case Presentation. A 36-year-old Caucasian woman presented to the emergency department with fatigue and dyspnea on minimal exertion. Physical examination was unremarkable except for pallor and noninjected conjunctiva. Laboratory tests revealed high LDH and low hemoglobin, white blood cells, platelets, and haptoglobin. The peripheral blood smear showed schistocytes suggestive of pseudothrombotic microangiopathy. Low cobalamin level and hyperhomocysteinemia were also detected. Autoimmune atrophic gastritis was confirmed by gastric biopsy and positive anti-intrinsic factor antibodies. Vitamin B12 supplements were given which led to rapid recovery and normalization of blood parameters. Conclusion. This case highlights the importance and serves as a reminder to clinicians to rule out cobalamin deficiency and autoimmune atrophic gastritis in patients presenting with a picture suggestive of thrombotic thrombocytopenic purpura and pancytopenia, which was completely reversible after appropriate replacement therapy without recurring to unnecessary and invasive procedures such as plasma exchange.

  18. Detection and characterization of stomach cancer and atrophic gastritis with fluorescence and Raman spectroscopy

    Science.gov (United States)

    Li, Xiaozhou; Lin, Junxiu; Jia, Chunde; Wang, Rong

    2003-12-01

    In this paper, we attempt to find a valid method to distinguish gastric cancer and atrophic gastritis. Auto-fluorescence and Raman spectroscopy of laser induced (514.5 nm and 488.0 nm) was measured. The serum spectrum is different between normal and cancer. Average value of diagnosis parameter for normal serum, red shift is less than 12 nm and Raman relative intensity of peak C by 514.5 nm excited is stronger than that of 488.0 nm. To gastric cancer, its red shift of average is bigger than 12 nm and relative intensity of Raman peak C by 514.5 nm excited is weaker than that by 488.0 nm. To atrophic gastritis, the distribution state of Raman peaks is similar with normal serum and auto-fluorescence spectrum's shape is similar to that of gastric cancer. Its average Raman peak red shift is bigger than 12 nm and the relative intensity of peak C by 514.5 excited is stronger than that of by 488.0. We considered it as a criterion and got an accuracy of 85.6% for diagnosis of gastric cancer compared with the result of clinical diagnosis.

  19. Autoimmune Metaplastic Atrophic Gastritis: Recognizing Precursor Lesions for Appropriate Patient Evaluation.

    Science.gov (United States)

    Pittman, Meredith E; Voltaggio, Lysandra; Bhaijee, Feriyl; Robertson, Scott A; Montgomery, Elizabeth A

    2015-12-01

    Autoimmune metaplastic atrophic gastritis (AMAG) is a significant risk factor for pernicious anemia and gastric neoplasia. Still, the histologic features of AMAG are frequently overlooked, especially in the early stages of the disease. The purpose of our study, therefore, was to catalogue the progression of histologic changes that precede the development of AMAG in affected individuals. Over a 2-year period (2012 to 2014), the diagnosis of AMAG was rendered on material from 113 patients seen at Johns Hopkins Hospital (∼1.8% of "in house" gastric biopsies). Prior gastric body biopsies had been performed on 54 (48%) patients in the cohort, and the majority of these specimens had also shown AMAG. Eighteen of the previous biopsies, however, carried a diagnosis other than AMAG: 13 inactive chronic gastritis, 2 acute Helicobacter pylori gastritis, and 1 each of eosinophilic gastritis, iron pill gastritis, and proton-pump inhibitor-like effect. Upon review of these 18 biopsies, the most common histologic findings were heavy full-thickness or deep lamina propria chronic inflammation (12), inflammatory destruction of oxyntic glands (12), metaplasia (intestinal, pyloric, or pancreatic acinar) (10), prominent lamina propria eosinophils (8), and parietal cell pseudohypertrophy (4). At least 2 of these features were present in the majority (13, 72%) of the biopsies. In addition, 7 (58%) of these patients were also found to have another autoimmune or inflammatory disorder before the diagnosis of AMAG. Although subtle, histologic features of developing AMAG are identifiable in routine gastric body biopsies. When metaplasia, full-thickness chronic inflammation, and/or oxyntic destruction are seen, a note suggesting laboratory testing and/or close clinical follow-up in this subset of patients may be warranted. PMID:26291507

  20. Effects of He-Ne laser irradiation on chronic atrophic gastritis in rats

    Institute of Scientific and Technical Information of China (English)

    Xue-Hui Shao; Yue-Ping Yang; Jie Dai; Jing-Fang Wu; Ai-Hua Bo

    2005-01-01

    AIM: To study the effects of He-Ne laser irradiation on experimental chronic atrophic gastritis (CAG) in rats.METHODS: Sixty-three male adult Wistar rats were randomly divided into five groups including normal control group, model control group and three different dosages He-Ne laser groups. The chronic atrophic gastritis (CAG)model in rats was made by pouring medicine which was a kind of mixed liquor including 2% sodium salicylate and 30% alcohol down the throat for 8 wk to stimulate rat gastric mucosa, combining with irregular fasting and compulsive sporting as pathogenic factors; 3.36, 4.80, and 6.24J/cm2doses of He-Ne laser were used, respectively for three different treatment groups, once a day for 20 d. The pH value of diluted gastric acid was determined by acidimeter,the histopathological changes such as the inflammatory degrees in gastric mucosa, the morphology and structure of parietal cells were observed, and the thickness of mucosa was measured by micrometer under optical microscope.RESULTS: In model control group, the secretion of gastric acid was little, pathologic morphological changes in gastric mucosa such as thinner mucous, atrophic glands, notable inflammatory infiltration were found. After 3.36 J/cm2 dose of He-Ne laser treatment for 20 d, the secretion of gastric acid was increased (P<0.05), the thickness of gastric mucosa was significantly thicker than that in model control group (P<0.01), the gastric mucosal inflammation cells were decreased (P<0.05). Morphology, structure and volume of the parietal cells all recuperated or were closed to normal.CONCLUSION: 3.36J/cm2 dose of He-Ne laser has a significant effect on CAG in rats.

  1. Association of tumor necrosis factor genetic polymorphism with chronic atrophic gastritis and gastric adenocarcinoma in Chinese Han population

    Institute of Scientific and Technical Information of China (English)

    Bao-Ying Fei; Bing Xia; Chang-Sheng Deng; Xiao-Qing Xia; Min Xie; J Bart A Crusius; A Salvador Pena

    2004-01-01

    AIM: To investigate the association of TNF polymorphisms with chronic atrophic gastritis (CAG) and gastric adenocarcinoma in Chinese Han patients.METHODS: The TNFa-e 5 microsatellites and 3 RFLP sites were typed using PCR technique, followed by high-voltage denaturing PAGE with silver staining and restriction enzyme digestion respectively in specimens from 53 patients with CAG and 56 patients with gastric adenocarcinoma and 164 healthy controls. The PCR products were cloned and sequenced.RESULTS: The frequency of TNF-β Ncol*1/2 genotype was higher in patients with chronic atrophic gastritis than in healthy controls, but no significant difference was observed (60.38% vs 46.34%, P=0.076). The frequency of TNa10 allele was significantly higher in patients with chronic atrophic gastritis than in healthy controls (19.81% vs 11.89%,P=0.04). However, it did not relate to age, gender, atrophic degree or intestinal metaplasia in patients with chronic atrophic gastritis. The frequency of TNF-β Ncol*1/2 and d2/d6 genotypes were significantly higher in patients with gastric adenocarcinoma than in healthy individuals(P>0.05).However, TNF-β Ncol*1/2 and d2/d6 genotypes did not relate to age, gender, grade of differentiation and clinicopathologic stage in patients with gastric adenocarcinoma. The frequency of TNFa6b5c1 haplotype homozygote was significantly lower in patients with gastric adenocarcinoma than in healthy controls (1.79% vs15.85%, P=0.006).CONCLUSION: TNFa10 allele may be a risk factor for chronic atrophic gastritis. TNF-β Ncol*1/2 and d2/d6 genotypes are associated with the susceptibility to gastric adenocarcinoma,whereas TNFa6b5c1 haplotype homozygote may contribute to the resistance against gastric adenocarcinoma.

  2. Study on histogenesis of enterochromaffin-like carcinoid in autoimmune atrophic gastritis associated with pernicious anemia

    Directory of Open Access Journals (Sweden)

    Mačukanović-Golubović Lana

    2007-01-01

    Full Text Available Background/Aim. Autoimmune atrophic fundic gastritis induces the pernicious anemia (PA, as well as the changes in both epithelium and endocrine cells of gastric mucosa. The most important complications are: achlorhydria, hypergastrinemia, gastric cancer and enterochromaffin-like ( ECL carcinoid. The aim of this study was to examine ECL carcinoid histogenesis in A-gastritis associated with PA. Methods. During the period from 2000−2006, 65 patients with PA and 30 patients of the control group were examined. Histopathological examination was done in endoscopical biopsies of gastric mucosa fixed in 10% formaldehyde. Paraffin sections were stained with classic hematoxylin-eosin (HE; histochemical AB-PAS (pH 2.5, cytochemical argyrophilic Servier-Munger′s and immunocytochemical PAP methods for G cell identification and chromogranin A antibodies - specific marker for neuroendocrine ECL cells. Both G and ECL cells were counted per 20 fields, of surface 0.0245312 mm2 by a field. Basal gastrin serum levels were also examined by using radioimmunoassay (RIA method. The obtained results were statisticaly calculated by using Student΄s t test. Results. Marked antral G cell hyperplasia associated with corporal ECL hyperplasia was found. ECL cell hyperplasia was of simplex, linear, adenomatoid type to the pattern of intramucous ECL cell carcinoid. An average number of G cells was statistically significant in the patients with PA as compared to the control group (p < 0.05 as well as an average number of ECL cells. Conclusion. We concluded that antral G cell hyperplasia accompanied by gastrinemia induces ECL hyperplasia and ECL corporal carcinoid in A-gastritis and that their histogenesis develops trough simple, linear and adenomatoide hyperplasia. .

  3. PREVALENCE OF HELICOBACTER PYLORI INFECTION IN PATIENTS WITH ATROPHIC GASTRITIS AND ROLE OF DARK FIELD MICROSCOPY IN DIAGNOSIS

    Directory of Open Access Journals (Sweden)

    Ananthamurugan

    2015-11-01

    Full Text Available BACKGROUND: Helicobacter pylori is the most common human pathogen which causes chronic gastritis, leading to serious complications. The aim was to study the incidence of H. pylori infection and the risk factors associated with chronic atrophic gastritis using simple diagnostic procedures. MATERIALS AND METHODS: Biopsy samples were collected from 146 chronic atrophic gastritis patients. Rapid Urease Test (RUT and dark field microscopy were used to diagnose the presence of H. pylori infection. The prevalence rate of H. pylori infection in relation to age, sex, smoking and alcohol consumption was studied. RESULTS: 88 (60.27% cases were positive for RUT and also for the characteristic cork screw motility under dark field microscopy. Prevalence rate was high in younger age group and among female. We found no correlation of H. pylori infection with smoking and alcohol consumption. CONCLUSION: It has been found that H. pylori is a major causative agent for atrophic gastritis and RUT is a simple cost efficient diagnostic test for H. pylori. The association of H. pylori infection with age, sex, smoking and alcohol consumption is variable and requires further studies to establish any relationship.

  4. Effects of Helicobacter pylori eradication on atrophic gastritis and intestinal metaplasia: A 3-year follow-up study

    Institute of Scientific and Technical Information of China (English)

    Bin Lu; Ming-Tao Chen; Yi-Hong Fan; Yan Liu; Li-Na Meng

    2005-01-01

    AIM: To investigate the effect of H pylori eradication on atrophic gastritis and intestinal metaplasia (IM).METHODS: Two hundred and fifty-nine patients with atrophic gastritis in the antrum were included in the study, 154 patients were selected for H pylori eradication therapy and the remaining 105 patients served as untreated group. Gastroscopy and biopsies were performed both at the beginning and at the end of a 3-year follow-up study. Gastritis was graded according to the updated Sydney system.RESULTS: One hundred and seventy-nine patients completed the follow-up, 92 of them received H pylori eradication therapy and the remaining 87 H pyloriinfected patients were in the untreated group. Chronic gastritis, active gastritis and the grade of atrophy significantly decreased in H pylori eradication group (P<0.01). However, the grade of IM increased in H pylori -infected group (P<0.05).CONCLUSION: H pylori eradication may improve gastric mucosal inflammation, atrophy and prevent the progression of IM.

  5. Body mass index, chronic atrophic gastritis and heartburn: a population-based study among 8936 older adults from Germany

    OpenAIRE

    Gao, Lei; Weck, Melanie Nicole; Rothenbacher, Dietrich; Brenner, Hermann

    2010-01-01

    Abstract Background: Obesity and overweight have been positively related to gastroesophageal reflux disease (GERD). It has been suggested, that this relation is due to an increased gastric acid reflux which is caused by an enhanced intra-abdominal pressure. Aim: We aimed to assess potential interaction of the association between body mass index (BMI) and GERD by chronic atrophic gastritis (CAG) which goes along with reduced acid production. Methods: In the baseline examinat...

  6. Caveolin-1, E-cadherin and β-catenin in Gastric Carcinoma, Precancerous Tissues and Chronic Non-atrophic Gastritis

    Institute of Scientific and Technical Information of China (English)

    Guo-yang Sun; Jun-xia Wu; Jian-sheng Wu; Yu-ting Pan; Rong Jin

    2012-01-01

    Objective:To investigate the expressions of caveolin-1,E-cadherin and β-catenin in gastric carcinoma,precancerous gastric and chronic non-atrophic gastritis tissues,and evaluate the correlation of these expressions with the development of gastric cancer.Methods:The expressions of caveolin-1,E-cadherin and β-catenin were detected by biotin-streptavidinperoxidase (SP) immunohistochemistry on 58 gastric cancer tissues,40 precancerous gastric tissues and 42 chronic non-atrophic gastritis tissues.The correlation between the expressions of caveolin-1,E-cadherin and β-catenin,and the clinicopathologic parameters of gastric cancer was analyzed retrospectively.Results:The positive rates of caveolin-1 and E-cadherin expressions in gastric carcinoma were significantly lower than precancerous gastric and chronic non-atrophic gastritis tissues (P<0.01).An abnormal rate of β-catenin expression in gastric carcinoma was higher than precancerous gastric and chronic non-atrophic gastritis tissues (P<0.01).Moreover,low expressions of caveolin-1,E-cadherin and β-catenin correlated with tumor size,depth of invasion,lymph node metastasis and TNM stage (P<0.05).The positive rates of caveolin-1 and E-cadherin expressions decreased (P<0.01),while an abnormal rate of β-catenin expression increased inversely,with the degree of atypical hyperplasia (P<0.01).Caveolin-1 expression correlated positively with E-cadherin (r=0.41,P<0.05).Caveolin-1 (r=-0.36,P<0.05) and E-cadherin (r=-0.45,P<0.05) expressions negatively correlated with abnormal β-catenin expression.Conclusion:These results suggested that dysregulated expressions of caveolin-1,E-cadherin and β-catenin correlated with the development of gastric cancer and its biological behavior.

  7. Artificial neural networks in the recognition of the presence of thyroid disease in patients with atrophic body gastritis

    Institute of Scientific and Technical Information of China (English)

    Edith Lahner; Marco Intraligi; Massimo Buscema; Marco Centanni; Lucy Vannella; Enzo Grossi; Bruno Annibale

    2008-01-01

    AIM: To investigate the role of artificial neural networks in predicting the presence of thyroid disease in atrophic body gastritis patients.METHODS: A dataset of 29 input variables of 253 atrophic body gastritis patients was applied to artificial neural networks (ANNs) using a data optimisation procedure (standard ANNs, T&T-IS protocol, TWIST protocol). The target variable was the presence of thyroid disease.RESULTS: Standard ANNs obtained a mean accuracy of 64.4% with a sensitivity of 69% and a specificity of 59.8% in recognizing atrophic body gastritis patients with thyroid disease. The optimization procedures (T&T-IS and TWIST protocol) improved the performance of the recognition task yielding a mean accuracy, sensitivity and specificity of 74.7% and 75.8%, 78.8% and 81.8%, and 70.5% and 69.9%, respectively. The increase of sensitivity of the TWIST protocol was statistically significant compared to T&T-IS.CONCLUSION: This study suggests that artificial neural networks may be taken into consideration as a potential clinical decision-support tool for identifying ABG patients at risk for harbouring an unknown thyroid disease and thus requiring diagnostic work-up of their thyroid status.

  8. DNA repair gene polymorphisms and risk of chronic atrophic gastritis: a case-control study

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    Raum Elke

    2011-10-01

    Full Text Available Abstract Background Recent studies have reported associations of DNA repair pathway gene variants and risk of various cancers and precancerous lesions, such as chronic atrophic gastritis (CAG. Methods A nested case-control study within the German population-based ESTHER cohort was conducted, including 533 CAG cases and 1054 controls. Polymorphisms in eleven DNA repair genes (APEX1, ERCC1, ERCC2/XPD, PARP1 and XRCC1, in CD3EAP/ASE-1 and PPP1R13L were analysed. Results No association was disclosed for any of the analysed polymorphisms. Nor did stratified analyses according to ages Conclusions The results of this large German case-control study do not reveal associations of DNA repair pathway polymorphisms and risk of CAG. On the basis of a large number of CAG cases, they do not support associations of DNA repair pathway SNPs with CAG risk, but suggest the need of larger studies to disclose or exclude potential weak associations, or of studies with full coverage of candidate genes.

  9. The Diagnostic Value of Gastrin-17 Detection in Atrophic Gastritis: A Meta-Analysis.

    Science.gov (United States)

    Wang, Xu; Ling, Li; Li, Shanshan; Qin, Guiping; Cui, Wei; Li, Xiang; Ni, Hong

    2016-05-01

    A meta-analysis was performed to assess the diagnostic value of gastrin-17 (G-17) for the early detection of chronic atrophic gastritis (CAG).An extensive literature search was performed, with the aim of selecting publications that reported the accuracy of G-17 in predicting CAG, in the following databases: PubMed, Science Direct, Web of Science, Chinese Biological Medicine, Chinese National Knowledge Infrastructure, Wanfang, and VIP. To assess the diagnostic value of G-17, the following statistics were estimated and described: sensitivity, specificity, diagnostic odds ratios (DOR), summary receiver operating characteristic curves, area under the curve (AUC), and 95% confidence intervals (CIs).Thirteen studies that met the inclusion criteria were included in this meta-analysis, comprising 894 patients and 1950 controls. The pooled sensitivity and specificity of these studies were 0.48 (95% CI: 0.45-0.51) and 0.79 (95% CI: 0.77-0.81), respectively. The DOR was 5.93 (95% CI: 2.93-11.99), and the AUC was 0.82.G-17 may have potential diagnostic value because it has good specificity and a moderate DOR and AUC for CAG. However, more studies are needed to improve the sensitivity of this diagnostic tool in the future. PMID:27149493

  10. Broccoli consumption and chronic atrophic gastritis among Japanese males: an epidemiological investigation.

    Directory of Open Access Journals (Sweden)

    Sato K

    2004-06-01

    Full Text Available Previous in vitro and animal experiments have shown that sulforaphane, which is abundant in broccoli, inhibits Helicobacter pylori (H. pylori infection and blocks gastric tumor formation. This suggests that broccoli consumption prevents chronic atrophic gastritis (CAG introduced by H. pylori infection and, therefore, gastric cancer. For an epidemiological investigation of the relationship between the broccoli consumption and CAG, a cross-sectional study of 438 male employees, aged 39 to 60 years, of a Japanese steel company was conducted. CAG was serologically determined with serum cut-off values set at pepsinogen I < or = 70 ng/ml and a ratio of serum pepsinogen I/pepsinogen II < or = 3.0. Broccoli consumption (weekly frequency and diet were monitored by using a 31-item food frequency questionnaire. The prevalence of CAG among men who ate broccoli once or more weekly was twice as high as that among men who consumed a negligible amount (P < 0.05. Multiple logistic regression analysis indicated that broccoli consumption once or more weekly significantly increased the risk for CAG (odds ratio, 3.06; 95% confidence interval, 1.12-8.38; P < 0.05, after controlling for age, education, cigarette smoking, and alcohol consumption. The present study failed to show an expected association between frequent broccoli consumption and a low prevalence of CAG.

  11. Expression of growth hormone and its receptor in chronic atrophic gastritis and its clinical significance

    Institute of Scientific and Technical Information of China (English)

    Jian-Min Si; Qian Cao; Min Gao

    2004-01-01

    AIM: To investigate the growth hormone (GH) and growth hormone receptor (GHR) expression of and its clinical significance in patients with chronic atrophic gastritis (CAG).METHODS:A total of 90 cases were enrolled in the study.Thirty were healthy controls,the other 60 patients were divided into two groups according to the endoscopical and histological diagnosis.Blood samples were drawn in the morning (menarche did not occur during the blood extraction in female patients),gastric mucosa was obtained by endoscopy.Serum GH and gastrice mucosal GHR levels were measured using radioimmunoassay (RIA) and En Vinsion technique.RESULTS:The average GH level was 1.021±0.132μ/L in CAG patients,in controls it was 2.869 0.512μ/L.There was a significant difference between these two groups(P<0.01).The positive rate of GHR in CAG patients was 10%,in controls the rate was 100%.There was a significant difference (P<0.01).There was no significant change of GH level (3.176±0.421μ/L) in patients with gastric carcinoma compared with controls (P>0.05).CONCLUSION:The study shows that levels of GH and GHR expression are low in CAG patients.CAG pathogenesis has a correlation with mucosal nutrient deficiency,decreased levels of GH and GHR have an adverse effect on the repair and regeneration of CAG.There is no significant change of GH in gastric carcinorma patients,GH dose not play a role in the pathogenesis of gastric cancer.

  12. Effect of Hewei-Decoction on chronic atrophic gastritis and eradication of Helicobacter pylori

    Institute of Scientific and Technical Information of China (English)

    Wan-Sheng Ji; Zhi-Xing Gao; Kai-Chun Wu; Jun-Wen Qiu; Bing-Long Shi; Dai-Ming Fan

    2005-01-01

    AIM: To demonstrate the effect of Hewei-Decoction(Decoction for regulating the stomach) on chronic atrophic gastritis (CAG) and eradication of Helicobacter pylori.METHODS: Ninety patients with CAG entering the investigation were divided into six differentiation syndromes, based on their major symptoms and signs.Hewei-Decoction was taken by all the patients orally for 4or 8 wk. The efficacy was assessed by both the composite accumulation of reduced scores of major symptoms and the eradication of H pylori.χ2 test was used to compare the efficacy between Hpylori-positive and negative cases,and to disclose the relationship between efficacy and eradication of H pylori.REStULTS: In patients with six different syndrome types,the efficacy of Hewei-Decoction was 91.67% (11/12),92.86% (13/14), 97.22% (35/36), 87.50% (14/16),75.00% (6/8), 75.00% (3/4) respectively. The rate of highly efficacious was 58.33% (7/12), 50.00% (7/14),77.78% (28/36), 62.50% (10/16), 12.50% (1/8) and25.00% (1/4), respectively. The total efficacy was 91.11%(82/90), and the rate of highly efficacious was 60.00%(54/90). The eradication rate of H pyloriwas 67.86%(38/56). The therapeutic effect of Hewei-Decoction was better in H pylori positive cases than that in Hpylori-negative cases with the total effect of 96.43% vs82.35% (P<0.05).In 56 H pylori positive cases, the therapeutic effect was better in H pylori eradicated cases than that in H pyloriexistent cases with the total effect of 97.37% vs 72.22%(P<0.01).CONCLUSION: Hewei-Decoction is effective in most cases of all the syndrome types. The results indicate that eradication of H pylori is one of the important mechanisms for alleviation of symptoms and signs. Also, the decoction is efficacious in H pylori-negative cases.

  13. Gastritis

    Science.gov (United States)

    ... Disease Organizations​​ (PDF, 341 KB)​​​​​ Alternate Language URL Gastritis Page Content On this page: What is gastritis? ... Nutrition Points to Remember Clinical Trials What is gastritis? Gastritis is a condition in which the stomachlining— ...

  14. Effect of experimental immune atrophic gastritis on the induction of gastric carcinoma by x-irradiation in ICR mice

    International Nuclear Information System (INIS)

    Divided doses of 6,000 or 8,000 rad of x-ray were given to the gastric region of ICR/JCL female mice with immune atrophic gastritis produced by the injection with allogenic stomach antigen. The carcinogenic effect of x-rays for inducing gastric carcinoma was significantly increased by this method. Two points can be presented as its reason. First, the pyloric gland mucosa regenerating from injuries by immunization was exposed to the divided doses of x-rays. Second, the marked requirement of gastrin secretion attributable to severe injuries of parietal cell mass by immunization and local x-irradiation acted as a promoting factor on the induction of gastric carcinoma by x-ray for a long time through the trophic effects on the pyloric gland. (auth.)

  15. [Mining analysis and experience summary for chronic atrophic gastritis cases treated by Professor LIU Feng-bin].

    Science.gov (United States)

    Hou, Zheng-kun; Liu, Feng-bin; Li, Pei-wu; Zhuang, Kun-hai

    2015-06-01

    To summarize Professor LIU Feng-bin's clinical experience and theoretical thoughts on chronic atrophic gastritis (CAG), the study group designed a retrospective study on his case series and expert interview. First of all, the data of CAG patients treated in the First Affiliated Hospital of Guangzhou University of Chinese Medicine between 2009 and 2013, e. g. herbs, diseases, syndrome type, prescription amount and number of herbs, was collected and processed. The statistical description and binary logistic regression were used to determined the syndrome type, initial basic remedy and modification. During the statistics, a complete and sub-group analysis was performed simultaneously. After the expert interview, the syndrome type and medication were finalized. As a result, a total of 228 CAG patients aged at (50.30 ± 10.18) were collected, including 151 males (66.23%). Of them, the TCM diagnosis and syndrome type were extracted from the information of 157 patients, including 115 cases with gastric stuffiness, 23 cases with gastric pain, 19 missing cases, 2 cases with spleen-stomach weakness syndrome, 57 cases with spleen deficiency and dampness-heat syndrome, 18 cases with spleen-stomach disharmony syndrome, 23 cases with syndrome of liver depression syndrome, 21 cases with liver qi invading stomach syndrome and 26 qi and yin deficiency syndrome, respectively. All of the 228 patients used totally 104 herbs, while the subgroups with 157 patients used 94 herbs. The most frequently used 15 herbs used in each groups were analyzed to determine the initial basic remedy and modification. Subsequently, based on the information of the sub-groups with 157 patients, with the syndrome type as the dependent variable, the logistic regression analysis was made on the most frequently used 32 herbs, in order to determined the modification in herbs for different syndrome types. After experts reviewed and modified, they believed the main causes of CAG were dietary irregularities

  16. Role of the IL-11/STAT3 signaling pathway in human chronic atrophic gastritis and gastric cancer.

    Science.gov (United States)

    Wang, D Q; Ding, X P; Yin, S; Mao, Y D

    2016-01-01

    The expression of interleukin-11 (IL-11) and its products STAT3 and phospho-STAT3 (p-STAT3) in patients with chronic superficial gastritis (CSG), chronic atrophic gastritis (CAG), and gastric cancer (GC) may provide insight into the diagnostic role of the IL-11/STAT3 signaling pathway in GC. Gastric mucosa specimens and serum samples were collected from 90 patients with CSG, CAG, and GC (30/group). The expression of IL-11, STAT3, and p-STAT3 was detected via immunohistochemistry and western blot. Additionally, serum levels of IL-11 were measured by enzyme-linked immunosorbent assay. For IL-11, 60% stained positive in CAG and 83.3% stained positive in GC, which were both higher than the value observed for CSG (33.3%). Moreover, the percent positive for IL-11 in GC was higher than that in CAG (P < 0.05). The percent positive for STAT3 in CAG (80%) and GC (83.3%) was higher than that in CSG (53.3%) (P < 0.05). Compared with CSG (36.7%), the percent positive for p-STAT3 in CAG (63.3%) and GC (86.7%) was also significantly higher. STAT3 expression was similar in GC and CAG, which was significantly higher than that in CSG. Expectedly, p-STAT3 expression gradually increased from CSG to CAG to GC. Furthermore, p-STAT3 levels were higher in GC tissues than in CAG (P < 0.01). Intriguingly, serum IL-11 levels gradually increased from CSG to CAG to GC, which coincided with disease severity. Together, these results suggest that the IL-11/STAT3 signaling pathway plays a critical role in human CAG, and may provide new targets to prevent and treat GC. PMID:27173233

  17. Localised Skin Hyperpigmentation as a Presenting Symptom of Vitamin B12 Deficiency Complicating Chronic Atrophic Gastritis.

    Science.gov (United States)

    El-Shafie, Kawther; Samir, Nafisa; Lakhtakia, Ritu; Davidson, Robin; Al-Waili, Ahmed; Al-Mamary, Muna; Al-Shafee, Mohammed

    2015-08-01

    Vitamin B12 deficiency is common in developing countries and should be suspected in patients with unexplained anaemia or neurological symptoms. Dermatological manifestations associated with this deficiency include skin hyper- or hypopigmentation, angular stomatitis and hair changes. We report a case of a 28-year-old man who presented to the Sultan Qaboos University Hospital in Muscat, Oman, in November 2013 with localised hyperpigmentation of the palmar and dorsal aspects of both hands of two months' duration. Other symptoms included numbness of the hands, anorexia, weight loss, dizziness, fatigability and a sore mouth and tongue. There was no evidence of hypocortisolaemia and a literature search revealed a possible B12 deficiency. The patient had low serum B12 levels and megaloblastic anaemia. An intrinsic factor antibody test was negative. A gastric biopsy revealed chronic gastritis. After B12 supplementation, the patient's symptoms resolved. Family physicians should familiarise themselves with atypical presentations of B12 deficiency. Many symptoms of this deficiency are reversible if detected and treated early. PMID:26357561

  18. Localised Skin Hyperpigmentation as a Presenting Symptom of Vitamin B12 Deficiency Complicating Chronic Atrophic Gastritis

    Directory of Open Access Journals (Sweden)

    Kawther El-Shafie

    2015-08-01

    Full Text Available Vitamin B12 deficiency is common in developing countries and should be suspected in patients with unexplained anaemia or neurological symptoms. Dermatological manifestations associated with this deficiency include skin hyper- or hypopigmentation, angular stomatitis and hair changes. We report a case of a 28-year-old man who presented to the Sultan Qaboos University Hospital in Muscat, Oman, in November 2013 with localised hyperpigmentation of the palmar and dorsal aspects of both hands of two months’ duration. Other symptoms included numbness of the hands, anorexia, weight loss, dizziness, fatigability and a sore mouth and tongue. There was no evidence of hypocortisolaemia and a literature search revealed a possible B12 deficiency. The patient had low serum B12 levels and megaloblastic anaemia. An intrinsic factor antibody test was negative. A gastric biopsy revealed chronic gastritis. After B12 supplementation, the patient’s symptoms resolved. Family physicians should familiarise themselves with atypical presentations of B12 deficiency. Many symptoms of this deficiency are reversible if detected and treated early.

  19. Possible contribution of artificial neural networks and linear discriminant analysis in recognition of patients with suspected atrophic body gastritis

    Institute of Scientific and Technical Information of China (English)

    Edith Lahner; Enzo Grossi; Marco Intraligi; Massimo Buscema; Vito D Corleto; Gianfranco Delle Fave; Bruno Annibale

    2005-01-01

    AIM: To investigate whether ANNs and LDA could recognize patients with ABG in a database, containing only clinical and biochemical variables, of a pool of patients with and without ABG, by selecting the most predictive variables and by reducing input data to the minimum.METHODS: Data was collected from 350 consecutive outpatients (263 with ABG, 87 with non-atrophic gastritis and/or celiac disease [controls]). Structured questionnaires with 22 items (anagraphic, anamnestic, clinical, and biochemical data) were filled out for each patient. All patients underwent gastroscopy with biopsies. ANNs and LDA were applied to recognize patients with ABG.Experiment 1: random selection on 37 variables, experiment 2: optimization process on 30 variables, experiment 3:input data reduction on 8 variables, experiment 4: use of only clinical input data on 5 variables, and experiment 5:use of only serological variables.RESULTS: In experiment 1, overall accuracies of ANNs and LDA were 96.6% and 94.6%, respectively, for predicting patients with ABG. In experiment 2, ANNs and LDA reached an overall accuracy of 98.8% and 96.8%,respectively. In experiment 3, overall accuracy of ANNs was 98.4%. In experiment 4, overall accuracies of ANNs and LDA were, respectively, 91.3% and 88.6%. In experiment 5, overall accuracies of ANNs and LDA were,respectively, 97.7% and 94.5%.CONCLUSION: This preliminary study suggests that advanced statistical methods, not only ANNs, but also LDA,may contribute to better address bioptic sampling during gastroscopy in a subset of patients in whom ABG may be suspected on the basis of aspecific gastrointestinal symptoms or non-digestive disorders.

  20. An Observational Study on Aberrant Methylation of Runx3 With the Prognosis in Chronic Atrophic Gastritis Patients.

    Science.gov (United States)

    Zhao, Chunna; Li, Ping; Zhang, Lili; Wang, Bei; Xiao, Lili; Guo, Feng; Wei, Yueguang

    2016-05-01

    The aim of this study is to discuss whether the methylation levels of Runx3 could be used as the early biomarker for predicting the prognosis in chronic atrophic gastritis (CAG) patients. A total of 200 subjects including 60 controls without CAG (Group 1), 70 patients with mild CAG (Group 2), and 70 patients with moderate and severe CAG (Group 3) were recruited for this cross-sectional investigation in the Department of Gastroenterology in Daqing Oilfield General Hospital from July 2013 to May 2014. The MlALDI-TOF-MS was used to measure the methylation levels of Runx3 in all of the subjects. Real-time quantitative reverse transcription polymerase chain reaction and western blotting were chosen to determine the expression levels of Runx3. The correlations between methylation levels of Runx3 among these CAG patients and their prognosis were shown by logistic regression models. The results demonstrated that the methylation levels of CpG13, CpG14, and CpG15 in Runx3 were higher in Group 3 than those in Groups 1 and 2 (P <0.05), whereas the mRNA and protein expression levels of Runx3 were lower in Group 3 than those in Groups 1 and 2 (P <0.05). There were significantly negative correlations between the methylation levels of Runx3 with its expression and the healing prognosis of CAG patients. In brief, this study proved that the hypermethylation modifications of CpG13, CpG14, and CpG15 in the promoter region of Runx3 could result in the down regulation of Runx3 expression to affect the prognosis of CAG. So the methylation levels of these CpG sites in Runx3 in the peripheral blood can be used as the biomarker for predicting the healing prognosis of CAG patients. PMID:27196446

  1. The interaction effects of pri-let-7a-1 rs10739971 with PGC and ERCC6 gene polymorphisms in gastric cancer and atrophic gastritis.

    Directory of Open Access Journals (Sweden)

    Qian Xu

    Full Text Available BACKGROUND: The aim of this study was to investigate the interaction effects of pri-let-7a-1 rs10739971 with pepsinogen C (PGC and excision repair cross complementing group 6 (ERCC6 gene polymorphisms and its association with the risks of gastric cancer and atrophic gastritis. We hoped to identify miRNA polymorphism or a combination of several polymorphisms that could serve as biomarkers for predicting the risk of gastric cancer and its precancerous diseases. METHODS: Sequenom MassARRAY platform method was used to detect polymorphisms of pri-let-7a-1 rs10739971 G → A, PGC rs4711690 C → G, PGC rs6458238 G → A, PGC rs9471643 G → C, and ERCC6 rs1917799 in 471 gastric cancer patients, 645 atrophic gastritis patients and 717 controls. RESULTS: An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 rs1917799 polymorphism was observed for the risk of gastric cancer (P interaction = 0.026; and interaction effects of pri-let-7a-1 rs10739971 polymorphism with PGC rs6458238 polymorphism (P interaction = 0.012 and PGC rs9471643 polymorphism (P interaction = 0.039 were observed for the risk of atrophic gastritis. CONCLUSION: The combination of pri-let-7a-1 rs10739971 polymorphism and ERCC6 and PGC polymorphisms could provide a greater prediction potential than a single polymorphism on its own. Large-scale studies and molecular mechanism research are needed to confirm our findings.

  2. Ten year follow up study of lymphocytic gastritis: further evidence on Helicobacter pylori as a cause of lymphocytic gastritis and corpus gastritis.

    OpenAIRE

    Niemelä, S.; Karttunen, T.; Kerola, T; Karttunen, R.

    1995-01-01

    AIMS--To examine the course of lymphocytic gastritis and its relation to Helicobacter pylori (H pylori) infection in a 10 year follow up. METHODS--Ninety six patients were originally examined for dyspepsia in 1981. Gastroscopies with stepwise biopsies were performed on all the patients initially and after an interval of 10 years. RESULTS--Nine per cent of the patients (9/96) had features of lymphocytic gastritis in gastric biopsy at the first examination, and 12.5% (12/96) at the second exami...

  3. The changing and its interaction of determining serum gastrin levels and helicobacter pylori test during chronic atrophic gastritis into gastric cancer

    International Nuclear Information System (INIS)

    Objective: To study the changing and its interaction of determining serum gastrin levels and Helicobacter pylori test during chronic atrophic gastritis into gastric cancer. Methods: RIA and 13C-urea breath test (13C-UBT) determined the Gs levels and Hp infection rate in 63 rate cases (first visit) patients, 48 cases (after one year return visit) patients, 35 cases (after three year return visit) patients and 30 cases (after five years return visit) patients with CAG 90 cases patients with gastric cancer (and different position) and 61 cases normal controls. They all were done study compared. Results: Serum Gs levels in 63 cases (first visit) patients, 48 cases (after one year return visit) patients, 35 cases (after three year return visit) patients and 30 cases (after five years return visit) patient with CAG were significantly higher (t=4.716, 5.218, 5.624, 6.179, 6.5772, all P0.05). Serum Gs levels in 90 cases with gastric cancer (and different position) was significantly higher (t=4.221, P<0.05; t=4.436, P<0.01) than 61 cases normal controls and the highest serum Gs level was found in cancer of cardia and fundus. And Hp infection rate was 88.8%. Conclusion: The early diagnosis on gastric cancer was very important by determining serum Gs and Hp infection rate. (authors)

  4. Gene expression of ornithine decarboxylase, cyclooxygenase-2, and gastrin in atrophic gastric mucosa infected with Helicobacter pylori before and after eradication therapy.

    Science.gov (United States)

    Konturek, Peter C; Rembiasz, Kazimierz; Konturek, Stanislaw J; Stachura, Jerzy; Bielanski, Wladyslaw; Galuschka, K; Karcz, Danuta; Hahn, Eckhart G

    2003-01-01

    H. pylori (Hp) -induced atrophic gastritis is a well-known risk factor for the development of gastric cancer. Whether Hp eradication can prevent or retard the progress of atrophy and metaplasia has been the topic of numerous studies but the subject remains controversial. Recently, the increased expression of ornithine decarboxylase (ODC), gastrin and cyclooxygenase (COX)-2 has been shown to be increased in premalignant lesions in gastric mucosa and to play an essential role in the malignant transformation. The aim of the study is to assess the effect of eradication therapy on atrophic gastritis and analyze the gene expression for ODC, COX-2 and gastrin in gastric mucosa after succesful eradication in patients with atrophic gastritis. Twenty patients with chronic atrophic gastritis including both corpus and antrum of the stomach were included in this study. Four antral mucosal biopsy specimens were obtained from antrum and four from corpus. The histopathologic evaluation of gastritis was based on Sydney classification of gastritis. All patients were Hp positive based on the [13C] urea breath test (UBT) and the presence of anti-Hp IgG and anti-CagA-antibodies detected by ELISA. The patients were then eradicated with triple therapy consiting of omeprazol (2 x 20 mg), amoxycillin (2 x 1 g) and clarithromycin (2 x 500 mg) for seven days and vitamin C 1 g/day for three months. In gastric mucosal samples obtained from the antrum and corpus before and after eradication, the mRNA expression for ODC, COX-2, and gastrin was assessed by reverse-transcription polymerase chain reaction (RT-PCR). In all patients the gastric secretory analysis was performed by measuring gastric acid output and serum gastrin levels. After triple therapy the successful eradication assessed by UBT was observed in 95% of patients. In 45% of patients the infection with CagA-positive Hp strain was observed. Three months after eradication a significant reduction in the gastric activity (neutrophilic

  5. Netazepide, a gastrin receptor antagonist, normalises tumour biomarkers and causes regression of type 1 gastric neuroendocrine tumours in a nonrandomised trial of patients with chronic atrophic gastritis.

    Directory of Open Access Journals (Sweden)

    Andrew R Moore

    Full Text Available INTRODUCTION: Autoimmune chronic atrophic gastritis (CAG causes hypochlorhydria and hypergastrinaemia, which can lead to enterochromaffin-like (ECL cell hyperplasia and gastric neuroendocrine tumours (type 1 gastric NETs. Most behave indolently, but some larger tumours metastasise. Antrectomy, which removes the source of the hypergastrinaemia, usually causes tumour regression. Non-clinical and healthy-subject studies have shown that netazepide (YF476 is a potent, highly selective and orally-active gastrin/CCK-2 receptor antagonist. Also, it is effective in animal models of ECL-cell tumours induced by hypergastrinaemia. AIM: To assess the effect of netazepide on tumour biomarkers, number and size in patients with type I gastric NETs. METHODS: We studied 8 patients with multiple tumours and raised circulating gastrin and chromogranin A (CgA concentrations in an open trial of oral netazepide for 12 weeks, with follow-up 12 weeks later. At 0, 6, 12 and 24 weeks, we carried out gastroscopy, counted and measured tumours, and took biopsies to assess abundances of several ECL-cell constituents. At 0, 3, 6, 9, 12 and 24 weeks, we measured circulating gastrin and CgA and assessed safety and tolerability. RESULTS: Netazepide was safe and well tolerated. Abundances of CgA (p<0.05, histidine decarboxylase (p<0.05 and matrix metalloproteinase-7(p<0.10 were reduced at 6 and 12 weeks, but were raised again at follow-up. Likewise, plasma CgA was reduced at 3 weeks (p<0.01, remained so until 12 weeks, but was raised again at follow-up. Tumours were fewer and the size of the largest one was smaller (p<0.05 at 12 weeks, and remained so at follow-up. Serum gastrin was unaffected. CONCLUSION: The reduction in abundances, plasma CgA, and tumour number and size by netazepide show that type 1 NETs are gastrin-dependent tumours. Failure of netazepide to increase serum gastrin further is consistent with achlorhydria. Netazepide is a potential new treatment for type 1 NETs

  6. Histopathological Characteristics of Atrophic Gastritisin Adult Population

    Institute of Scientific and Technical Information of China (English)

    Marija Milicevic; Snezana Bozanic; Nenad Solajic

    2015-01-01

    Introduction: Chronic gastritis is inflammation of the gastric mucosa. It can be non-atrophic and atrophic. Atrophy isdefined as the loss of appropriate glands. It is frequently located in antral mucosa as consequence of Helicobacter pylori infectionand it is associated with intestinal gastric cancer. Goal: Describe histopathological and demographic characteristics of atrophicgastritis. Matherial and methods: We assessed the pathological reports of 100 patients with atrophic gastritis whose characteristicswere evaluated by using a semiquantitative scale of Sidney system of classification of gastritis. To assess the significance betweenthe incidence of various parametres we used ;~2 test. Results: We found that the difference in frequency of atrophic gastritis betweenmen and women was not statistically significant. The difference in distribution is statistically significant in favor of the antrum.Among patients who have atrophy with Helicobacterpylori infection and intestinal metaplasia and those who do not have metaplasia,it was found that the difference is highly statistically significant. Conclusion: The most frequent localisation of atrophic gastritis isantral mucosa. There is no difference between men and women in frequency of atrophic gastritis, while the aging is related with moreoften occurrence of atrophic gastritis.

  7. Effect of Amoxicillin Combined With Bismuth Pectin in the Treatment of Chronic Atrophic Gastritis%阿莫西林配合果胶铋治疗慢性萎缩性胃炎的效果探讨

    Institute of Scientific and Technical Information of China (English)

    苏同森; 刘文翠; 王均成

    2016-01-01

    Objective To observe and analyze the clinical effect of amoxicilin and bismuth pectin bismuth in treatment of chronic atrophic gastritis. Methods According to the principle of voluntary patients,94 cases of chronic atrophic gastritis patients composition study group(47 cases)and control group(47 cases),the former treated with amoxicilin and bismuth pectin,the latter to be clarithromycin and coloidal bismuth pectin treatment,and compared between the two groups of patients with clinical curative effect observation.ResultsThe effective rate of the study group(93.6%)was significantly higher than that in the control group(76.6%),the difference was statisticaly significant(P<0.05,χ2=8.115),recurrence rate of the study group(6.4%) was lower than that of the control group(12.8%),the difference was statisticaly significant(P<0.05,χ2=7.361).Conclusion The effect of amoxicilin combined with bismuth pectin bismuth on chronic atrophic gastritis is significant,and the recurrence rate is low.%目的:观察与分析阿莫西林联合果胶铋在慢性萎缩性胃炎疾病治疗中的临床运用效果。方法依据患者自愿原则,将94例慢性萎缩性胃炎患者成分研究组(47例)与对照组(47例),前者予以阿莫西林+果胶铋治疗,后者予以克拉霉素+果胶铋治疗;观察与比较两组患者的临床疗效。结果研究组患者治疗后的有效率(93.6%)比对照组患者(76.6%)高,差异有统计学意义(P<0.05,χ2=8.115);研究组患者复发率(6.4%)低于对照组(12.8%),差异有统计学意义(P<0.05,χ2=7.361)。结论采取阿莫西林联合果胶铋治疗慢性萎缩性胃炎,效果显著,且复发率低。

  8. 阿莫西林配合果胶铋治疗慢性萎缩性胃炎的效果探讨%Effect of Amoxicillin Combined With Bismuth Pectin in the Treatment of Chronic Atrophic Gastritis

    Institute of Scientific and Technical Information of China (English)

    苏同森; 刘文翠; 王均成

    2016-01-01

    目的:观察与分析阿莫西林联合果胶铋在慢性萎缩性胃炎疾病治疗中的临床运用效果。方法依据患者自愿原则,将94例慢性萎缩性胃炎患者成分研究组(47例)与对照组(47例),前者予以阿莫西林+果胶铋治疗,后者予以克拉霉素+果胶铋治疗;观察与比较两组患者的临床疗效。结果研究组患者治疗后的有效率(93.6%)比对照组患者(76.6%)高,差异有统计学意义(P<0.05,χ2=8.115);研究组患者复发率(6.4%)低于对照组(12.8%),差异有统计学意义(P<0.05,χ2=7.361)。结论采取阿莫西林联合果胶铋治疗慢性萎缩性胃炎,效果显著,且复发率低。%Objective To observe and analyze the clinical effect of amoxicilin and bismuth pectin bismuth in treatment of chronic atrophic gastritis. Methods According to the principle of voluntary patients,94 cases of chronic atrophic gastritis patients composition study group(47 cases)and control group(47 cases),the former treated with amoxicilin and bismuth pectin,the latter to be clarithromycin and coloidal bismuth pectin treatment,and compared between the two groups of patients with clinical curative effect observation.ResultsThe effective rate of the study group(93.6%)was significantly higher than that in the control group(76.6%),the difference was statisticaly significant(P<0.05,χ2=8.115),recurrence rate of the study group(6.4%) was lower than that of the control group(12.8%),the difference was statisticaly significant(P<0.05,χ2=7.361).Conclusion The effect of amoxicilin combined with bismuth pectin bismuth on chronic atrophic gastritis is significant,and the recurrence rate is low.

  9. Genetic alterations in benign lesions: Chronic gastritis and gastric ulcer

    OpenAIRE

    César, Ana Cristina Gobbo; Calmon, Marília de Freitas; Cury, Patrícia Maluf; Caetano, Alaor; Borim, Aldenis Albaneze; Silva, Ana Elizabete

    2006-01-01

    AIM: To investigate the occurrence of chromosome 3, 7, 8, 9, and 17 aneuploidies, TP53 gene deletion and p53 protein expression in chronic gastritis, atrophic gastritis and gastric ulcer, and their association with H pylori infection.

  10. Clinical significance of expression of livin and cyclin D1 in chronic atrophic gastritis with intestinal metaplasia%Livin和CyclinD1在慢性萎缩性胃炎伴肠化黏膜中的表达及意义

    Institute of Scientific and Technical Information of China (English)

    陈吉; 崔宏; 高美丽; 崔琴

    2012-01-01

    目的:探讨凋亡抑制蛋白Livin和细胞周期蛋白D1(CyclinDI)在慢性萎缩性胃炎(chronicatrophic gastritis,CAG)伴肠化癌变过程中的表达及其相关性.方法:应用免疫组织化学染色S-P法检测Livin和CyclinD1在30例慢性浅表性胃炎(chronicsuperficial gastritis,CSG)、35例CAG非肠化、35例CAG伴肠化、30例胃癌组织中的表达,并同时研究二者在CAG伴肠化癌变中表达的相关性.结果:在CSG、CAG非肠化、CAG伴肠化、胃癌中Livin、CyclinD1的阳性表达率分别为:0%、10%; 28.57%、14.29%; 45.71%、37.14%; 66.67%、53.33%,二者在CAG(非肠化)和CSG对比均有统计学意义(P<0.05);CAG(伴肠化)与CAG(非肠化)相比,CyclinD1的阳性表达率有统计学意义(P<0.05); Livin和CyclinD1在CAG伴肠化、胃癌组织中表达呈正相关.结论:Livin、CyclinD1蛋白在CAG(伴肠化)和胃癌组织中表达呈上调状态,且CAG(伴肠化)和胃癌组织间无显著差异,二者表达一致,提示CAG(伴肠化)已具有癌变的分子生物学特征.二者在胃癌的发生、发展中起协同作用,对其进行联合检测将有助于胃癌的早期诊断.%AIM: To investigate the expression of livin and cyclinDl in chronic atrophic gastritis with intestinal metaplasia.METHODS: Immunohistochemistry was used to examine the expression of livin and cyclin Dl in 30 cases of chronic superficial gastritis, 35 cases of atrophic gastritis without intestinal metaplasia, 35 cases of atrophic gastritis with intestinal metaplasia, and 30 cases of gastric carcinoma. We also explored the correlation between livin and cyclin Dl expression in chronic atrophic gastritis and gastric carcinoma.RESULTS: The positive rates of livin expression in the specimens of chronic superficial gastritis,atrophic gastritis without intestinal metaplasia, atrophic gastritis with intestinal metaplasia, and gastric carcinoma were 0%, 28.57%, 45.71% and 66.67%, respectively, and the corresponding rates for

  11. Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori-associated chronic atrophic gastritis: A follow-up study of patients with endoscopically resected colorectal neoplasia

    OpenAIRE

    Inoue, Izumi; Kato, Jun; Yoshimura, Noriko; Maeda, Yoshimasa; Moribata, Kosaku; Shingaki, Naoki; Deguchi, Hisanobu; Enomoto, Shotaro; Maekita, Takao; UEDA, KAZUKI; Iguchi, Mikitaka; Tamai, Hideyuki; FUJISHIRO, MITSUHIRO; Yamamichi, Nobutake; Takeshita, Tatsuya

    2012-01-01

    In a previous population-based case-control study, we demonstrated an elevated risk of colorectal neoplasia with Helicobacter pylori (H. pylori) infection. The present study investigated the effects of H. pylori-associated chronic gastritis on the development of colorectal neoplasia by analyzing the recurrence of colorectal neoplasia subsequent to endoscopic resection. Ninety-nine patients who had undergone endoscopic resection of colorectal neoplasia were monitored under colonoscopy, and the...

  12. 萎缩性胃炎脾气虚证免疫小分子蛋白组表达的研究%Study on Atrophic Gastritis in Immunity Micromolecule Proteome of Spleen-qi Deficiency

    Institute of Scientific and Technical Information of China (English)

    时小红; 徐珊

    2012-01-01

    [Objective] Atrophic gastritis is a disease with intestinal metaplasia, and reveals that human immune system (cells, body fluids, partial immunity) is in a low state. "Spleen is a defense banier to pathogenic qi," "if spleen function maintains normal all the time, human body will not be ill," that reveals the immune role of the spleen. In modern medicine, spleen is regarded as immune response and immune material base, one of the barriers of the human immune system. Because proteomics is not anatomical concept of organs and tissues etc., but involves in certain aspects' alteration in biochemistry and internal relationship of disease processes. These physiological and pathological viewpoints are in coincident with TCM holism. From the angle of immunity micro-molecule proteome, atrophic gastritis spleen-qi deficiency substance will be elaborated.%萎缩性胃炎(AG)是人体整体免疫力(细胞、体液、局部免疫)低下,多种因素长期作用而表现胃局部、常伴肠化的病症.“脾为之卫”、“四季脾旺不受邪”,表现脾的免疫防卫作用,现代医学也认为脾是免疫应答和产生免疫效应物质的重要基地,人体免疫系统的屏障之一.由于蛋白质组学的研究不是从器官组织的解剖学定位出发,强调生物化学某一环节的改变和疾病过程的内在联系,与中医学整体的生理病理观有更多的切合点,本文旨在从免疫小分子蛋白质组表达规律的角度观察与AG脾气虚证的相关性.

  13. Increased Production of Lysozyme Associated with Bacterial Proliferation in Barrett's Esophagitis, Chronic Gastritis, Gluten-induced Atrophic Duodenitis (Celiac Disease), Lymphocytic Colitis, Collagenous Colitis, Ulcerative Colitis and Crohn's Colitis.

    Science.gov (United States)

    Rubio, Carlos A

    2015-12-01

    The mucosa of the esophagus, the stomach, the small intestine, the large intestine and rectum are unremittingly challenged by adverse micro-environmental factors, such as ingested pathogenic and non-pathogenic bacteria, and harsh secretions with digestive properties with disparate pH, as well as bacteria and secretions from upstream GI organs. Despite the apparently inauspicious mixture of secretions and bacteria, the normal GI mucosa retains a healthy state of cell renewal. To by-pass the tough microenvironment, the epithelia of the GI react by speeding-up cell exfoliation, by increasing peristalsis, eliminating bacteria through secretion of plasma cell-immunoglobulins and by increasing production of natural antibacterial enzymes (lysozyme) and host defense peptides (defensin-5). Lysozyme was recently found up-regulated in Barrett's esophagitis, in chronic gastritis, in gluten-induced atrophic duodenitis (celiac disease), in collagenous colitis, in lymphocytic colitis and in Crohn's colitis. This up-regulation is a response directed towards the special types of bacteria thriving in the microenvironment in each of the aforementioned clinical inflammatory maladies. The purpose of that up-regulation is to protect the mucosa affected by the ongoing chronic inflammation. Bacterial antibiotic resistance continues to exhaust our supply of effective antibiotics. The future challenge is how to solve the increasing menace of bacterial resistance to anti-bacterial drugs. Further research on natural anti-bacterial enzymes such as lysozyme, appears mandatory. PMID:26637845

  14. Acupuncture Decreases NF-κB p65, miR-155, and miR-21 and Increases miR-146a Expression in Chronic Atrophic Gastritis Rats

    Science.gov (United States)

    Zhang, Jialing; Huang, Kangbai; Zhong, Guoxin; Huang, Yong; Li, Suhe; Qu, Shanshan; Zhang, Jiping

    2016-01-01

    Acupuncture has been used to treat chronic atrophic gastritis (CAG) in traditional Chinese medicine (TCM) for centuries. In this study, we evaluated the effect of acupuncture at Zusanli (ST36), Zhongwan (CV12), and Pishu (BL20) acupoints on weight changes of rats, histological changes of gastric glands, and expressions changes of nuclear factor-kappa B (NF-κB) p65, microRNA- (miR-) 155, miR-21, and miR-146a in CAG rats induced by N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) combined with irregular diet. Consequently, we found that acupuncture treatment elevated body weight of rats significantly when compared to the model group. By observing histological changes, we found that the acupuncture group showed better improvement of gastric mucosa injury than the model group. Our results also demonstrated upregulation of NF-κB p65, miR-155, and miR-21 in gastric tissue of CAG rats and a positive correlation between miR-155 and miR-21. Relatively, expression of miR-146a was downregulated and negative correlation relationships between miR-146a and miR-155/miR-21 in CAG rats were observed. Additionally, expressions of NF-κB p65, miR-155, and miR-21 were downregulated and miR-146a was upregulated after acupuncture treatment. Taken together, our data imply that acupuncture can downregulate NF-κB p65, miR-155, and miR-21 and upregulate miR-146a expression in CAG rats. NF-κB p65, miR-155, miR-21, and miR-146a may play important roles in therapeutic effect of acupuncture in treating CAG. PMID:27293468

  15. Impact on Gastric Mucosa Histopathology of Atrophic Gastritis by Traditional Chinese Drug Prescription Based on Asthenia Syndrome Depression Syndrome Poison Syndrome Static Blood Syndrome%从虚郁毒瘀立法组方对萎缩性胃炎鼠模型胃黏膜病理的影响

    Institute of Scientific and Technical Information of China (English)

    王常松; 王启国; 俞杰; 闵莉; 吴银盘

    2011-01-01

    Objective: To observe intervention of the traditional Chinese drug prescription based on asthenia syndrome, depression syndrome, poison syndrome, static blood syndrome on gastric mucosa histopathology, of atrophic gastritis.Methods: Alcohol, deoxysodium cholate, ammonia solution, indometacin and disorder between feeding and fasting were used to build the mode]of atrophic gastritis, which were treated respectively by the high-dose, mid-dose, low-dos traditional Chinese drug prescription based on asthenia syndrome, depression syndrome, poison syndrome, static Blood syndrome, and their therapeutic effects were appreciated by the degree of gastric mucosa inflammation and atrophy, thickness of gastric mucosa.Results: The degree of gastric mucosa inflammation and atrophy, thickness of gastric mucosa became better by means of the model of atrophic gastritis treated by mid-dose of the traditional Chinese drug prescription based on asthenia syndrome, depression syndrome, poison syndrome, static blood syndrome.Conclusions: The therapeutic effect of atrophic gastritis treated by the traditional Chinese drug prescription based on asthenia syndrome, depression syndrome, poison syndrome, static blood syndrome is reliable.%目的:观测从虚郁毒瘀立法组方对萎缩性胃炎鼠模型胃黏膜病理形态的干预作用.方法:采用乙醇+去氧胆酸钠+氨水+吲哚美辛+饥饱失常综合法复制萎缩性胃炎鼠模型,并用从虚郁毒瘀立法组方低、中、高剂量分别进行干预,从对胃黏膜炎症及萎缩分度、胃黏膜厚度方面的影响观测各剂量组的治疗效果.结果:从虚郁毒瘀立法组方中剂量组可明显改善萎缩性鼠模型胃黏膜的炎症和萎缩程度,以及胃黏膜的厚度.结论:从虚郁毒瘀立法组方治疗萎缩性胃炎疗效可靠.

  16. ESTABLISHMENT OF MODIFIED RAT MODEL WITH CHRONIC ATROPHIC GASTRITIS INFECTED BY HELICOBACTER PYLORI%改良式Hp感染萎缩性胃炎大鼠模型的建立

    Institute of Scientific and Technical Information of China (English)

    唐旭东; 张翠萍; 张琪; 赵坤; 孙向红; 田字彬

    2012-01-01

    目的 建立较理想的幽门螺杆菌(Hp)感染慢性萎缩性胃炎(CAG)大鼠模型.方法 雄性Wistar大鼠60只,随机分为Hp感染及水杨酸钠乙醇灌胃组(模型组)、正常对照组(A组)、单纯Hp感染组(B组)、单纯水杨酸钠乙醇灌胃组(C组).采用灌胃接种Hp菌株(SSI)及20 g/L水杨酸钠与体积分数0.60的乙醇混合溶液方法建立Hp感染CAG模型,共14周.检测各组Hp定植情况,并对胃窦黏膜病理组织学各项指标进行评分.结果 模型组及B组胃窦黏膜均有Hp定植.模型组胃窦黏膜变薄,固有层腺体中度减少伴有中度慢性活动性炎症.模型组慢性炎症评分、活动性炎症评分及固有腺减少评分均明显高于A、B组(x2=47.632~48.276,q=6.514~11.191,P<0.01),而与C组比较,差异无显著性(P>0.05).结论 采用Hp感染大鼠及水杨酸钠与乙醇混合溶液灌胃的方法建立Hp感染CAG大鼠模型,其病因、病理变化与人类CAG病变相似,可作为研究Hp感染CAG发病机制及药物干预治疗CAG较合适的动物模型.%Objective To create a more ideal rat model of chronic atrophic gastritis 0. 05), Conclusion The causes of disease and pathological changes in rat models of CAG that created by Hp infection combined with mixed solution of sodium salicylate and ethanol are similar to that found in human subjects. This can be used as a suitable animal model in researching the mechanism of CAG due to Hp infection and drug therapy for this condition.

  17. The prediction vaule of pepsinogenⅠ combined with gastrin-17 in lesion location of chronic atrophic gastritis and the period of gastric cancer pro-gression%胃蛋白酶原Ⅰ联合胃泌素-17检测对慢性萎缩性胃炎发病部位及胃癌进展时期的预测价值

    Institute of Scientific and Technical Information of China (English)

    周海平

    2014-01-01

    目的:探讨胃蛋白酶原Ⅰ(PGⅠ)联合胃泌素-17(G-17)检测对慢性萎缩性胃炎发病部位及胃癌进展时期的预测价值。方法选择本院收治的慢性萎缩性胃炎患者33例、胃癌患者35例作为研究对象,进行PGⅠ、PGⅡ和G-17检测,比较并分析PGⅠ、PGⅡ及G-17水平的变化情况。结果慢性萎缩性胃炎组PGⅠ和G-17水平高于胃癌组,差异有统计学意义(P<0.05),胃窦部组的PGⅠ水平高于胃体部组和全胃弥漫组,差异有统计学意义(P<0.05),胃体部组的G-17水平高于全胃弥漫组和胃窦部组,差异有统计学意义(P<0.05),早期胃癌或原位癌的PGⅠ和G-17水平显著高于进展期胃癌,差异有统计学意义(P<0.05)。结论胃窦部发病为主的慢性萎缩性胃炎其G-17显著下降,胃体部或全胃病变者PGⅠ的下降更加明显,进展期胃癌者PGⅠ水平更低而G-17水平更高。%Objective To investigate the prediction vaule of pepsinogenⅠ combined with gastrin-17 in lesion location of chronic atrophic gastritis and the period of gastric cancer progression. Methods 33 cases with chronic atrophic gas-tritis and 35 cases in the different period of gastric cancer in our hospital were selected as research objects.All these participants were detected by pegsinogenⅠ,pegsinogenII and gastrin-17.The level of pegsinogenⅠ,pegsinogenII and gastrin-17 were compared and analyzed. Results The level of pepsinogens I and gastrin-17 in chronic atrophic gastri-tis group were higher than that in gastric cancer group,with statistical difference(P<0.05).Pepsinogen I level in the gas-tric antrum of chronic atrophic gastritis was higher than that in the gastric body and the total diffuse,with statistical dif-ference (P<0.05),the gastrin-17 level in the gastric body was higher than that in the total diffuse and in the gastric antrum,with statistical difference (P<0.05).Pepsinogen I and gastrin-17 lever of early gastric cancer and carcinoma

  18. Chronic gastritis

    OpenAIRE

    Sipponen, Pentti; Maaroos, Heidi-Ingrid

    2015-01-01

    Abstract Prevalence of chronic gastritis has markedly declined in developed populations during the past decades. However, chronic gastritis is still one of the most common serious pandemic infections with such severe killing sequelae as peptic ulcer or gastric cancer. Globally, on average, even more than half of people may have a chronic gastritis at present. Helicobacter pylori infection in childhood is the main cause of chronic gastritis, which microbial origin is the key for the understand...

  19. Chronic gastritis in China: a national multi-center survey

    OpenAIRE

    Du, Yiqi; Bai, Yu; Xie, Pei; Fang, Jingyuan; Wang, Xiaozhong; Hou, Xiaohua; TIAN, DEAN; Wang, Chengdang; Liu, Yandi; Sha, Weihong; Wang, Bangmao; Li, Yanqing; Zhang, Guoliang; Li, Yan; Shi, Ruihua

    2014-01-01

    Background Chronic gastritis is one of the most common findings at upper endoscopy in the general population, and chronic atrophic gastritis is epidemiologically associated with the occurrence of gastric cancer. However, the current status of diagnosis and treatment of chronic gastritis in China is unclear. Methods A multi-center national study was performed; all patients who underwent diagnostic upper endoscopy for evaluation of gastrointestinal symptoms from 33 centers were enrolled. Data i...

  20. Curative Effect Evaluation of Banxia Xiexin Decoction on Chronic Atrophic Gastritis (Cold-Heat Complicated Syndrome)Based on the Calibration Biopsy Technique%基于定标活检技术评价半夏泻心汤对慢性萎缩性胃炎(寒热错杂证)的疗效

    Institute of Scientific and Technical Information of China (English)

    刘洁; 刘琳; 李慧臻

    2013-01-01

    目的:基于定标活检技术评价半夏泻心汤对慢性萎缩性胃炎(寒热错杂证)的疗效.方法:符合诊断标准的病例30例,随机分为治疗组(半夏泻心汤组)和对照组(胃复春组),3个月为1个疗程.观察治疗前后两组的临床症状,并在定标活检下观察胃镜下病理改变情况.结果:临床症状:两组在改善症状方面均有效,治疗组优于对照组(P<0.05),内镜疗效无显著性差异(P>0.05).结论:半夏泻心汤可显著改善慢性萎缩性胃炎(寒热错杂证)的临床症状.%Objective: To make the curative effect evaluation of Banxia Xiexin Decoction on chronic atrophic gastritis (cold -heat complicated syndrome)based on the calibration biopsy technique. Methods:30 cases met the diagnostic criteria were randomly divided into the treatment group (Banxia Xiexin Decoction group) and the control group ( Weifuchun group) ,3 months was a treatment course. Before and after treatment the clinical symptoms were observed, and pathological changes were observed under gas-troscope biopsy in calibration. Results: Clinical symptoms: two groups in improving the symptoms were valid, the treatment group was better than control group (P 0. 05 ) . Conclusion: Banxia Xiexin Decoction can significantly improve chronic atrophic gastritis(cold-heat complicated syndrome) clinical symptoms.

  1. Cirurgia laparoscópica no diagnóstico de gastrite crônica atrófica seguida de tratamento clínico em cadela: relato de caso Laparoscopic surgery in the diagnosis of atrophic gastritis in a dog followed by clinical treatment: case report

    Directory of Open Access Journals (Sweden)

    P.C. Basso

    2007-10-01

    Full Text Available Descrevem-se o diagnóstico e o tratamento de um caso de gastrite atrófica crônica, em uma cadela sem raça definida, de dois anos de idade. A paciente apresentava como principal sintomatologia vômito crônico. O hemograma, a urinálise e as avaliações bioquímicas séricas não revelaram alterações significativas. Os exames radiológicos e ultra-sonográficos abdominais também não foram sugestivos de alterações. Realizaram-se inspeção da cavidade peritoneal, gastrotomia, gastroscopia, gastrectomia para biopsia e gastrorrafia intracorpórea videolaparoscópicas. Constatou-se ausência de rugosidades estomacais. Ao exame histológico, observou-se atrofia das células principais e parietais da mucosa gástrica. O quadro clínico permitiu o diagnóstico de gastrite crônica atrófica. O animal foi medicado com terapia imunossupressora e apresentou remissão completa dos sinais clínicos.This report describes a case of chronic atrophic gastritis. A two-year-old female mongrel dog showed chronic emesis. The complete blood count serum chemistry and urinalysis values were within the normal limits. Radiographs revealed no alterations. Abdominal evaluation, gastrotomy, gastroscopy, gastrectomy and intracorporeal stomach suture were done by laparoscopic approach. Absence of gastric villous was noticed through laparoscopic biopsy. The microscopic analysis reveled parietal and principal gastric mucosal cells atrophy, which, associated with clinical signs, allowed the chronic atrophic gastritis diagnosis. The animal was treated and clinical signs complete remission was observed.

  2. Erosive gastritis

    International Nuclear Information System (INIS)

    Erosive gastritis is a well-defined radiologic and endoscopic entity. It is one of the common causes of upper gastrointestinal bleeding, yet it is seldom diagnosed and often confused with a number of other diseases. This communication re-emphasizes the characteristic endoscopic and radiologic features of erosive gastritis and its differential diagnosis. Two representative cases are reported. (orig.)

  3. Autoradiographic studies on the cell proliferation of the human chronic gastritis

    International Nuclear Information System (INIS)

    Cell proliferation of human gastric mucosa was studied in the cases of chronic gastritis using the in vitro incubation method of 3H-thymidine autoradiography. The study was carried out using the material consisted of 92 biopsy specimens and 83 stomachs diagnosed as carcinoma, peptic ulcer, duodenal ulcer and chronic gastritis. The labelling index was expressed in a percentage of labelled cells in ratio to the total number of epithelial cells. In the normal gastric mucosae, 3H-TdR labeled cells were in the neck region of the gastric gland, but did not appear in the surface epithelium. Higher incorporation of 3H-TdR was observed in the lower part of the neck region of the glands. The average indices, both labeling and mitotic, were generally higher in the antrum than in the pylorus in the cases of chronic gastritis and also higher than normal mucosae. Superficial gastritis showed many labeled cells which were located in the neck region and foveolae. Simple gastitis showed scattered labeled cells in various parts of mucosae. In atrophic and atrophic hyperplastic gastritis, labeled cells were found in the neck and fobeolae of the gastric glands. Metaplastic gastritis showed labeled cells especially in the neck regions. The average labeling index is higher in simple chronic gastritis than in other superficial gastritis, atrophic, atrophic hyperplastic and metaplastic gastritis. Information concerned with cell renewal and proliferation is important for further understanding of the development of disease. (J.P.N.)

  4. 慢性萎缩性胃炎中医证型与幽门螺杆菌感染、病理分级的相关性研究%Study on correlation of syndrome types of TCM with H.pylori infection and pathological grade in chronic atrophic gastritis

    Institute of Scientific and Technical Information of China (English)

    宗湘裕; 王万卷; 刘宝珍; 杜长海; 赵景成

    2015-01-01

    Objective It is to study the relationship between H.pylori infection and pathological grade in chronic atrophic gastritis with syndrome types of TCM.Methods 106 cases of patients with chronic atrophic gastritis diagnosed by gastroscopy and pathology were divided into five groups according to TCM syndrome differentiation: spleen-stomach deficiency group, spleen-stomach dampness-heat group, stomach Yin deficiency group,liver and stomach disharmony group and blood stagna-tion of stomach collaterals group.The relationship of distribution of syndrome types of TCM with H.pylori infection, atrophy, intestinal metaplasia,dysplasia degree was observed and compared.Results Chronic atrophic gastritis in proportion from high to low were spleen and stomach deficiency type, dampness-heat of spleen and stomachtype, liver and stomach disharmony type,stomach Yin deficiency type and blood stagnation of stomach collaterals type.The total infection rates in proportion from high to low were dampness-heat of spleen and stomach type,liver and stomach disharmony type, blood stagnation of stomach collaterals type, spleen and stomach deficiency type, stomach Yin deficiency type, and the total infection rate was 58.49%. Mild atrophy of liver stomach disharmony of the ratio was higher.The proportion of spleen stomach damp heat syndrome, blood stasis syndrome of stomach meridian,stomach Yin deficiency syndrome in severe atrophy degree were higher than that of spleen and stomach weakness, liver and stomach disharmony type.No significant difference in proportion of mild to moderate atrophy, intestinal metaplasia among the five groups was found.The proportion of mild dysplasia was higher in spleen stomach damp heat syndrome, blood stasis syndrome than that in spleen and stomach deficiency syndrome,syndrome of incoordination between liv-er and stomach, deficiency of stomach Yin syndrome.The degree of gastric precancerous lesions of stomach meridian in the blood stasis was the highest, followed by

  5. Gastritis of the Herniated Stomach in Patients with Esophageal Hiatus Hernia

    Science.gov (United States)

    Forstner, G. G.; Bogoch, A.

    1963-01-01

    Seven illustrative cases of gastritis of the herniated stomach in patients with sliding esophageal hiatus hernia are reported. Five had superficial gastritis (three mild, one moderate and one severe); two had atrophic gastritis. Gastritis was present in two patients whose mucosa appeared normal at esophagoscopy. Interstitial hemorrhage into the lamina propria was present in four of the seven biopsy specimens. The possibility that interstitial hemorrhage may be related to the development of gastric erosions is considered. The pathogenesis of this form of gastritis is discussed. ImagesFig. 1Fig. 2Fig. 3 PMID:13958838

  6. A Case of H. pylori-associated Granulomatous Gastritis with Hypertrophic Gastropathy

    OpenAIRE

    Kim, Yeon Soo; Lee, Hye Kyung; Kim, Jong Ok; Lee, Seung Woo; Kang, Sang Beom; Nam, Soon Woo; Lee, Dong Soo

    2009-01-01

    A 46-year-old man had chronic granulomatous gastritis characterized by giant gastric folds with noncaseating epithelioid granulomas including giant cells in the corpus. No definite etiologic factors were detected. Histology and the rapid urease test indicated that H. pylori was present in both the antrum and corpus. The granulomatous gastritis with giant gastric folds improved after H. pylori eradication. This case suggests an association between isolated granulomatous gastritis and H. pylori...

  7. Diagnosis of autoimmune gastritis by high resolution magnification endoscopy

    Institute of Scientific and Technical Information of China (English)

    George K Anagnostopoulos; Krish Ragunath; Anthony Shonde; Christopher J Hawkey; Kenshi Yao

    2006-01-01

    Endoscopic visualisation of gastric atrophy is usually not feasible with conventional endoscopy. Magnifying endoscopy is helpful to analyze the subepithelial microvascular architecture as well as the mucosal surface microstructure without tissue biopsy. Using this technique we were able to describe the normal gastric microvasculature pattern and we also identified characteristic patterns in two cases of autoimmune atrophic gastritis.

  8. Systemic and local immune responses against Helicobacter pylori urease in patients with chronic gastritis: distinct IgA and IgG productive sites

    OpenAIRE

    Futagami, S; Takahashi, H.; Norose, Y; Kobayashi, M.

    1998-01-01

    Background—Helicobacter pylori urease is a major target for immune responses among various bacterial components in H pylori infected patients. 
Aims—To analyse the relation between systemic and local humoral immune responses to H pylori urease and grades of chronic gastritis. 
Patients—Seventy five patients with chronic gastritis associated with H pylori infection were classified into three groups (grade I, superficial gastritis; II, atrophic gastritis, quiescent; or III,...

  9. Radioimmunoassay of gastrin level in duodenal ulcer, atrophic gostritis and Addison-Biermer's disease

    International Nuclear Information System (INIS)

    Radioimmunoassay of gastrin level in the blood was performed in 20 controls, 12 patients with duodenal ulcer, 13 patients with atrophic gastritis and 14 patients with Addison-Biermer's disease. Gastrin level in the serum of the patients with duodenal ulcer did not differ significantly from that of controls. In atrophic gastritis and particularly in Addison-Biermer's disease gastrin level was found to be several times higher. This is probably a result of chronic gastrin secretion stimulation which is normally inhibited by gastric juice. (author)

  10. Effect of eradication of Helicobacter pylori on development and reversion of atrophic gastritis in animal study%幽门螺杆菌的根除与萎缩性胃炎形成和逆转的动物实验研究

    Institute of Scientific and Technical Information of China (English)

    胡品津; 曾志荣; 陈旻湖; 陈为; 彭晓忠; 林汉良

    2000-01-01

    目的明确根除幽门螺杆菌(Helicobacter pylori,Hp)对萎缩性胃炎的形成和逆转的影响。方法 110只2级C57BL/6小鼠随机分为实验组(60只)和对照组(50只)。实验组动物感染Hp后又随机分为A、B两组,并分别于感染后6个月和12个月根除Hp。采用悉尼系统、免疫组化及流式细胞术比较根除前后鼠腺胃黏膜组织学和细胞动力学。结果 (1)接受根除治疗的动物Hp检查均为阴性。根除Hp可明显改善A、B两组动物腺胃的慢性活动性炎症。A组动物在各时间点均未观察到萎缩的形成,B组动物于感染Hp后12个月腺胃出现萎缩性改变,根除Hp后3个月、6个月萎缩未有明显减轻。(2)根除Hp可明显改善腺胃黏膜细胞动力学,根除后6个月时S期细胞百分比(S%)、增殖指数(PI)和胃黏膜上皮细胞Brdu标记指数(LI)与同期对照组动物比较差异无显著性(P值均>0.05)。结论本研究表明,早期根除Hp可预防萎缩性胃炎的形成,对已形成的萎缩性胃炎无逆转作用,但可防止病变进一步发展。%Objective To investigate the effect of eradication of Helicobacter pylori (H. pylori) on de-velopment and reversion of atrophic gastritis by animal study. Methods One hundred and ten of two-grade C57BL/6 female mice were randomly divided into experimental group (60 mice) and control group (50 mice).The mice in experimental group were infected with SS1 H. pylori strain, and then randomly subdivided into group A and group B, 30 mice in each group. Group A and group B received a mouse equivalent dose of stan-dard bismuth triple therapy 6 and 12 months after infection respectively, 10 mice were subsequently sacrificed before the therapy, and 3 and 6 months after completion of the therapy, respectively, in each group.Histopathological features of the glandular stomach were graded as definiens in the Sydney System, and kinetic changes of mucosal epithelial cells of the glandular stomach

  11. LU Zheng's Experience in the Treatment of Atrophic Gastritis

    Institute of Scientific and Technical Information of China (English)

    CHEN Ming-xian

    2010-01-01

    @@ LU Zheng, male, born in 1938, a chief physician in Zhejiang Provincial Academy of TCM, is one of the second national batch of supervisors in the inheritance work of academic experiences of veteran TCM experts. He has his unique ideas on the TCM theories of toxicology, spleen and stomach, stimulation of kidney-qi, essential-qi, and kidneyessence. In clinical practice, he excels in treating diseases of internal medicine, gynecological and pediatric diseases, and the various stubborn and miscellaneous diseases.

  12. A genetic basis for atrophy: dominant non-responsiveness and helicobacter induced gastritis in F1 hybrid mice

    OpenAIRE

    Sutton, P.; Wilson, J.; Genta, R; Torrey, D; Savinainen, A; Pappo, J; Lee, A.

    1999-01-01

    BACKGROUND—The importance of host factors in helicobacter induced gastritis has been shown in animal models. Infection of most mouse strains with Helicobacter felis results in a functional atrophic gastritis, while other strains remain gastritis free.
AIMS—To investigate these host factors further by using genetic crosses of responder and non-responder mice.
METHODS—F1 hybrids of the non-responder CBA/Ca strain and three strains of mice known to develop H felis induced gastritis were infected...

  13. 加味七方胃痛颗粒对慢性萎缩性胃炎大鼠胃蛋白酶含量及HSP70蛋白表达的影响%Effect of Modified Qifang Weitong Granules on Pepsin Content and Heat Shock Protein 70 Expression in Rats with Chronic Atrophic Gastritis

    Institute of Scientific and Technical Information of China (English)

    唐梅文; 王伟; 李桂贤; 岳小红; 陈国忠; 邓嫦

    2011-01-01

    Objective To investigate the effects of Modified Qifan Weitong Granules(QWG) on pepsin content and heat shock protein 70(HSP70) expression in the gastric mucosa of rats with chronic atrophic gastritis(CAG).Methods CAG rat models were established by means of N-methyl-N'-nitro-N-nitrosoguanidine(MNNG), and the effect of QWG on relative indexes was observed and compared with that of Weifuchun Granules. Results Compared with the model group, the atrophy and intestinal metaplasia of gastric mucosa were relieved in large-and medium-dosage QWG groups and in Weifuchun Granules group, and the pepsin content and HSP70 expression were increased in large-, medium-and small-dosage QWG groups and in Weifuchun Granules group, the difference being significant(P< 0.01). Compared with Weifuchun Granules group, pepsin content and HSP70 expression in large-dosage QWG group were increased with statistical significance(P < 0.05). Conclusion The mechanism of QWG in preventing and treating CAG may be related with prevention of gastric mucosa through increasing pepsin con tent and HSP70 expression.%目的 探讨加味七方胃痛颗粒对慢性萎缩性胃炎(CAC)模型大鼠胃黏膜组织中胃蛋白酶含量及热休克蛋白70(HSP70)表达的影响.方法 采用化学致癌物N-甲基-N'-硝基-N-亚硝基胍(MNNG)建立CAG动物模型,以胃复春为对照组,观察加味七方胃痛颗粒对大鼠CAG相关指标的作用.结果 与模型组比较,加味七方胃痛颗粒高、中剂量组和胃复春组的胃黏膜萎缩程度、胃黏膜肠化生程度明显减轻(P<0.01);加味七方胃痛颗粒高、中、低剂量组和胃复春组胃蛋白酶的含量、HSP70蛋白表达显著增加(P<0.01);与胃复春组比较,加味七方胃痛颗粒高剂量组胃蛋白酶的含量、HSP70蛋白表达显著增加(P<0.05).结论 加味七方胃痛颗粒防治CAG的作用机制可能是通过升高胃蛋白酶的含量及促进HSP70的表达,从而发挥对黏膜保护作用.

  14. Study on correlation of pathological changes of chronic atrophic gastritis gastric mucosal precancerous lesions with TCM syndrome type and TRPV1, TRPM8%慢性萎缩性胃炎胃黏膜癌前病变病理变化与中医证型及 TRPV1、TRPM8的相关性研究

    Institute of Scientific and Technical Information of China (English)

    王俊; 黄雅慧

    2014-01-01

    Objective It is to observe the correlation of pathological changes of chronic atrophic gastritis ( CAG) precan-cerous lesions with TCM syndrome type and transient receptor potential (TRPV1, TRPM8), and provide more objective basis of TCM syndrome differentiation for CAG .Methods317 patients with CAG diagnosed by endoscopy and CAG with atypical hy-perplasia or different levels intestinal metaplasia diagnosed by pathology were selected ;10 cases with asymptomatic superficial gastritis found by regular physical examination were selected as a control .The detection of TRPV1 receptors , TRPM8 expres-sion and the CAG syndrome types of TCM syndrome differentiation were done , and the correlation of pathological changes of CAG with TCM syndrome type and the correlation of TRPV 1, TRPM8 expression were analyzed ,Results①The TCM syndrome type of CAG precancerous lesions were accorded to the sort of spleen deficiency and Qi stagnation >Spleen stomach damp heat >weakness of spleen and stomach >Liver stomach disharmony >Stomach yin deficiency >stomach collaterals stasis resistance .②There were significant difference in the expression of TRPV 1 and TRPM8 between the six TCM syndrome types . The syndrome types were sorted to Spleen stomach damp heat >Stomach yin deficiency >Liver stomach disharmony >stom-ach collaterals stasis resistance >spleen deficiency and Qi stagnation >weakness of spleen and stomach for TRPV 1 expres-sion and sorted to weakness of spleen and stomach >spleen deficiency and Qi stagnation >stomach collaterals stasis resist-ance >Liver stomach disharmony >Stomach yin deficiency >Spleen stomach damp heat for TRPM 8 expression .TRPV1 was expressed obviously in Spleen stomach damp heat type at 415 bp, TRPM8was expressed obviously in weakness of spleen and stomach type at387 bp.stomach collaterals stasis resistance type was similar the expression of superficial gastritis gastric mu -cosa.③There was significant difference in the same syndrome among different

  15. Campylobacter pylori gastritis.

    OpenAIRE

    Mahony, M. J.; Wyatt, J I; Littlewood, J M

    1988-01-01

    Campylobacter pylori colonisation of the stomach is strongly associated with type B non-autoimmune gastritis in adults. In a retrospective study of 38 gastric biopsy specimens taken during upper gastrointestinal endoscopy in children attending this hospital we found C pylori in nine (24%). Ten biopsy specimens showed histological evidence of gastritis and C pylori was found in eight.

  16. Helicobacter pylori gastritis

    International Nuclear Information System (INIS)

    This paper reports on the CT scans of patients with Helicobacter pylori (formerly Campylobacter pylori) infection and histologic gastritis reviewed to determine if the inflammatory changes can mimic the CT appearance of gastric neoplasm. Records were obtained of 288 consecutive cases of biopsy-confirmed. Helicobacter pylori gastritis, spanning a 21-month period from July 1988 to March 1990. Abdominal CT scans had been performed in 70 of these cases and were retrospectively reviewed. RESULTS: Seven of the 70 cases of confirmed Helicobacter pylori gastritis were suggestive of malignancy on CT

  17. Therapeutic effect of DA-9601 on chronic reflux gastritis induced by sodium taurocholate in rats

    Institute of Scientific and Technical Information of China (English)

    Tae Young Oh; Chang Yell Shin; Yong Sung Sohn; Dong Hwan Kim; Byoung Ok Ahn; Eun Bang Lee; Cho Hyun Park

    2005-01-01

    AIM: To investigate the therapeutic effects of DA-9601 on sodium taurocholate (TCA)-induced chronic reflux gastritis in SD rats.METHODS: In this study, we have investigated the therapeutic effects of DA-9601 on chronic erosive and atrophic gastritis induced by 6 mo of TCA administration (5 mmol/L in drinking water) in SD rats. RESULTS: Four weeks of DA-9601 administration (0.065%, 0.216% in rat chow), following the withdrawal of TCA treatment, resulted in a significant decrease in total length of erosions in rats in a dose-dependent manner. Furthermore, the indicators of atrophic gastritis, such as reduced mucosal thickness and reduction in the number of parietal cells, were improved by the administration of DA-9601 in a dose-related manner. DA-9601 also attenuated inflammatory cell infiltration and the proliferation of collagenous fiber in the gastric mucosa. The improvement in the reduction of the gastric mucus was observed in the rats receiving a high dose of DA-9601 (0.216%). The therapeutic effect of DA-9601 on experimental chronic erosive gastritis was superior to that of rebamipide (1.08% in rat chow). Biochemical analyses showed increased mucosal prostaglandin E2 and reduced glutathione levels by DA-9601 treatment. CONCLUSION: We suggest that DA-9601 is apromising agent for the treatment of chronic erosive and atrophic gastritis with an etiological factor of bile reflux. Increasedmucosal prostaglandin E2 and reduced glutathione by DA-9601 treatment may be therapeutic mechanisms for chronic erosive and atrophic gastritis.

  18. Topographic distribution of gastritis in heavy pigs investigated by a geographic information system approach.

    Science.gov (United States)

    Pascotto, Ernesto; Capraro, Diego; Tomè, Paolo; Spanghero, Mauro

    2016-01-01

    The aim of this paper was to determine the topographic distribution of gastritis lesions in pigs through an open source geographic information system (GIS) software analysis. The stomachs of 146 Italian heavy pigs were collected at slaughter and subjected to macroscopic pathological examination of the internal mucosa. A total of 623 lesions were either classified as hyperplastic or follicular (97%) with the remaining minority of lesions categorised as atrophic and simple. The hyperplastic gastritis lesions had an average surface of 77.8 cm2 and were mainly located in an oval shaped area of the fundus region of the stomach near the Curvatura ventriculi major. The follicular gastritis lesions had generally a smaller surface (40.3 cm2) and were concentrated in two distinct small areas of the pyloric region. The GIS analysis provided the opportunity to produce useful maps showing the distribution and characteristics of gastritis in pigs. PMID:27245806

  19. Histological study of chronic gastritis from the United Arab Emirates using the Sydney system of classification.

    OpenAIRE

    Zaitoun, A M

    1994-01-01

    AIMS--To determine the prevalence of Helicobacter pylori in five main nationality groups with gastric ulcer, duodenal ulcer, and non-ulcer dyspepsia; and to determine the histopathological types of gastritis and assess the graded variables of Helicobacter associated gastritis. METHODS--Gastric antral and corpus biopsy specimens from 437 patients were examined for the prevalence of H pylori, 337 of which were classified and graded histologically according to the Sydney system. RESULTS--The ove...

  20. Manifestation of Spontaneous and Early Autoimmune Gastritis in CCR7-Deficient Mice

    OpenAIRE

    Winter, Susann; Rehm, Armin; Wichner, Katharina; Scheel, Tobias; Batra, Arvind; Siegmund, Britta; Berek, Claudia; Lipp, Martin; Höpken, Uta E.

    2011-01-01

    Autoimmune gastritis is a common autoimmune disorder characterized by chronic inflammatory cell infiltrates, atrophy of the corpus and fundus, and the occurrence of autoantibodies to parietal cell antigen. In CCR7-deficient mice, autoimmune gastritis developed spontaneously and was accompanied by metaplasia of the gastric mucosa and by the formation of tertiary lymphoid organs at gastric mucosal sites. T cells of CCR7-deficient mice showed an activated phenotype in the gastric mucosa, mesente...

  1. The Updated Sydney System: Classification and Grading of Gastritis as the Basis of Diagnosis and Treatment

    OpenAIRE

    Stolte, Manfred; Meining, Alexander

    2001-01-01

    In recent years, the importance of the histological diagnosis of gastritis on the basis of routinely obtained antral and corpus biopsies has increased enormously, which is owed not least of all to the discovery of Helicobacter pylori. The introduction of the Sydney system made it possible, for the first time, to grade histological parameters, identify topographical distribution and, finally, make a statement about the etiopathogenesis of the gastritis. Of pathogenetic importance is, in the fi...

  2. Helicobacter pylori-associated gastritis and dyspepsia. The influence on migrating motor complexes

    DEFF Research Database (Denmark)

    Qvist, N; Rasmussen, L; Axelsson, C K

    1994-01-01

    Twenty-five patients with dyspepsia were included. In 19 patients with a median age of 48 (range, 20-72) years endoscopy and histologic examination of biopsy specimens from the antrum and corpus of the stomach showed Helicobacter pylori-positive gastritis as the only pathologic finding. In six......-positive gastritis. Nine patients were reexamined after eradication of the H. pylori infection, and the motility pattern had changed to the characteristics found in normals. In conclusion, the patients with dyspepsia and gastritis showed a disturbed motility pattern. The disturbance was similar whether there was...... patients with a median age of 42 (range, 32-56) years H. pylori-negative gastritis was found. After an overnight fast the patients underwent an ambulatory duodenal motility study for 6-8 h. Twenty-five young healthy men served as the control group. In patients with H. pylori-positive gastritis the duration...

  3. Frequency of precancerous lesions in endoscopic gastric biopsies in chronic gastritis

    International Nuclear Information System (INIS)

    Objective: To determine the frequency of precancerous lesions in endoscopic gastric biopsies of patients with chronic gastritis. Study Design: A case series. Place and Duration of Study: Department of Histopathology, Liaquat National Hospital, Karachi, from July 2008 to January 2009. Methodology: Over 6 months, 375 endoscopic gastric biopsies of patients with age group of 15-65 years having endoscopic chronic gastritis were included. From final biopsy report, basic information like patient demographics and presence of precancerous lesions i.e. activity (chronic active gastritis), atrophy (atrophic gastritis), intestinal metaplasia and dysplasia were recorded on proforma. Results were described as proportions and frequency. Results: The frequency of precancerous lesions in endoscopic gastric biopsies of patients with chronic gastritis in Karachi was markedly high. Most common lesion was chronic active gastritis as depicted by activity (48.3%); dysplasia (1.3%) was the least common. Proportion of more aggressive precancerous lesions were markedly higher in older age group (> 40 years). Conclusion: The precancerous lesions are frequent in endoscopic gastric biopsies of patients with chronic gastritis. (author)

  4. Helicobacter pylori, gastritis, and peptic ulceration in the elderly.

    OpenAIRE

    Wyatt, J I; Shallcross, T M; Crabtree, J E; Heatley, R V

    1992-01-01

    AIMS: To determine the histopathological types of gastritis, presence of H pylori, and of peptic ulceration in patients aged 70 and over, compared with younger adults. METHODS: Gastric antral and corpus biopsy specimens from 112 elderly patients were classified and graded histologically according to the Sydney system. Details of recent antibiotic and non-steroidal anti-inflammatory drug use were recorded. Eighty four of the patients were positive for H pylori IgG antibodies and parietal cell ...

  5. Helicobacter pylori gastritis and serum pepsinogen levels in a healthy population: development of a biomarker strategy for gastric atrophy in high risk groups.

    OpenAIRE

    T Knight; Wyatt, J.; Wilson, A.; GREAVES, S.; Newell, D; Hengels, K.; Corlett, M.; Webb, P.; Forman, D; Elder, J

    1996-01-01

    This study aimed to estimate the prevalence and type of chronic gastritis in an asymptomatic working population and to determine whether a combination of serum pepsinogen levels and Helicobacter pylori serology could be used to identify a subgroup with atrophic gastritis at elevated risk of gastric carcinoma. A 10% subsample of 544 male volunteer factory workers aged 18-63 years and participating in a larger study underwent endoscopy and biopsy. Of these men, 29 were seropositive for Helicoba...

  6. Helicobacter pyloriin gastric corpus of patients 20 years after partial gastric resection

    Institute of Scientific and Technical Information of China (English)

    Christian Kirsch; Ahmed Madisch; Petja Piehler; Ekkehard Bayerd(o)rffer; Manfred Stolte; Stephan Miehlke

    2004-01-01

    AIM: To determine the long-term prevalence of Helicobacter pylori (H pylori) gastritis in patients after partial gastric resection due to peptic ulcer, and to compare the severity of H pylori-positive gastritis in the corpus mucosa between partial gastrectomy patients and matched controls.METHODS: Endoscopic biopsies were obtained from 57 patients after partial gastric resection for histological examination using hematoxylin/eosin and Warthin-Starry staining. Gastritis was graded according to the updated Sydney system. Severity of corpus gastritis was compared between H pylori-positive partial gastrectomy patients and H pylori-positive duodenal ulcer patients matched for age and gender.RESULTS: In partial gastrectomy patients, surgery was performed 20 years (median) prior to evaluation. In 25 patients (43.8%) H pylori was detected histologically in the gastric remnant. Gastric atrophy was more common in H pylori-positive compared to H pylori-negative partial gastrectomy patients (P<0.05). The severity of corpus gastritis was significantly lower in H pylori-positive partial gastrectomy patients compared to duodenal ulcer patients (P<0.01). There were no significant differences in the activity of gastritis, atrophy and intestinal metaplasia between the two groups.CONCLUSION: The long-term prevalence of H pylorigastritis in the gastric corpus of patients who underwent partial gastric resection due to peptic ulcer disease is comparable to the general population. The expression of H pylori gastritis in the gastric remnant does not resemble the gastric cancer phenotype.

  7. Syphilitic gastritis: A case report

    International Nuclear Information System (INIS)

    Syphilitic involvement of the stomach often takes the appearance of neoplastic conditions. We describe the radiological findings of syphilitic gastritis. A 36 year old man was diagnosed with gastric cancer by upper GI and CT, but syphilitic gastritis was confirmed by endoscopy and upper GI series performed after penicillin therapy. We report a case of syphilitic gastritis presented as advanced stomach cancer by clinical, endoscopic and radiological study

  8. CT finding of emphysematous gastritis

    International Nuclear Information System (INIS)

    Emphysematous gastritis is a rare entity of infectious gastritis caused by gas-forming organisms and only 32 cases have been reported. CT is helpful in the diagnosis particularly in mild cases that there is only a small amount of gas. Typical CT findings of emphysematous gastritis are gas bubbles within the irregular thickened gastric wall and dilated stomach filled with secretions, debris and a large amount of gas. We report a case that was diagnosed by CT and operation.

  9. X-ray diagnosis of acute gastritis

    International Nuclear Information System (INIS)

    Abnormal gastric wall configurations in 27 cases of cause-unknown acute gastritis were studied roentgenographically with reference to their causative origins. Studies were made on roentgenograms (abnormal gastric wall configurations), endoscopic findings and extension of lesions of the subjected cases. Gastric contour showed 'staying', 'thumbprinting', 'undulate configuration' and 'squarish undulation', while 'chimney-like' finding suggestive of poor gastric wall stretch was observed in the whole antral region as well. The widened angulus ventriculi and expanded pyloric ring (insufficient constriction) were also seen. In some cases the lesion extended over to the duodenum and, as in the cases of acute gastritis, duodenal wall 'staying', 'thumbprinting' and varied duodenal wall undulation were seen in addition to edema and morphological changes of the Kerkring's folds. The lesions in the studied patients mostly extended from an epicenter of the antrum upward to the gastric corpus and downward near to Vater's papilla in the descending part of the duodenum. The affected regions were clearly distinguishable. It has been known that above-described roentgenographical findings in our studied patients were similar in part to those known in experimental studies carried out on animals with ischemic digestive tract. This strongly suggests that some of our patients had developed the disease due to ischemic causes. There were some discrepancies between roentgenographical (abnormal gastric wall configuration) and endoscopic findings in some studied patients. It has been our belief that abnormal gastric wall configuration reflects lesions in the inner part of the wall and, accordingly, roentgenographical examinations, as well as endoscopy, should be performed for the purpose of making correct diagnosis. It is also to be emphasized that angiography should be carried out on patients with relapsing acute gastritis without any specific cause. (author)

  10. Clinical Usefulness of the Serological Gastric Biopsy for the Diagnosis of Chronic Autoimmune Gastritis

    Directory of Open Access Journals (Sweden)

    Antonio Antico

    2012-01-01

    Full Text Available Aim. To assess the predictive value for chronic autoimmune gastritis (AIG of the combined assay of anti-parietal-cell antibodies (PCA, anti-intrinsic-factor antibodies (IFA, anti-Helicobacter pylori (Hp antibodies, and measurement of blood gastrin. Methods. We studied 181 consecutive patients with anemia, due to iron deficiency resistant to oral replacement therapy or to vitamin B12 deficiency. Results. 83 patients (45.8% tested positive for PCA and underwent gastroscopy with multiple gastric biopsies. On the basis of the histological diagnosis, PCA-positive patients were divided into 4 groups: (1 30 patients with chronic atrophic gastritis; they had high concentrations of PCA and gastrin and no detectable IFA; (2 14 subjects with metaplastic gastric atrophy; they had high PCA, IFA, and gastrin; (3 18 patients with nonspecific lymphocytic inflammation with increased PCA, normal gastrin levels, and absence of IFA; (4 21 patients with multifocal atrophic gastritis with “borderline” PCA, normal gastrin, absence of IFA and presence of anti-Hp in 100% of the cases. Conclusions. The assay of four serological markers proved particularly effective in the diagnostic classification of gastritis and highly correlated with the histological profile. As such, this laboratory diagnostic profile may be considered an authentic “serological biopsy.”

  11. Helicobacter heilmannii-associated Gastritis: Clinicopathologic Findings and Comparison with Helicobacter pylori-associated Gastritis

    OpenAIRE

    Joo, Mee; Kwak, Ji Eun; Chang, Sun Hee; Kim, Hanseong; Chi, Je G.; Kim, Kyung-Ah; Yang, Jeon Ho; Lee, June Sung; Moon, Young-Soo; Kim, Kyoung-Mee

    2007-01-01

    The aims of this study were to evaluate the clinicopathologic features of Helicobacter heilmannii-associated gastritis and to compare H. heilmannii-associated gastritis with H. pylori-associated gastritis. We reviewed 5,985 consecutive gastric biopsy specimens. All cases of chronic gastritis with Helicobacter infection were evaluated with the Updated Sydney System, and the grades of all gastritis variables were compared between H. heilmannii-associated gastritis and H. pylori-associated gastr...

  12. Helicobacter pylori infection, glandular atrophy and intestinal metaplasia in superficial gastritis, gastric erosion, erosive gastritis, gastric ulcer and early gastric cancer

    Institute of Scientific and Technical Information of China (English)

    Chuan Zhang; Nobutaka Yamada; Yun-Lin Wu; Min Wen; Takeshi Matsuhisa; Norio Matsukura

    2005-01-01

    AIM: To evaluate the histological features of gastric mucosa, including Helicobacter pylori infection in patients with early gastric cancer and endoscopically found superficial gastritis, gastric erosion, erosive gastritis,gastric ulcer.METHODS: The biopsy specimens were taken from the antrum, corpus and upper angulus of all the patients.Giemsa staining, improved toluidine-blue staining, and H pylori-specific antibody immune staining were performed as appropriate for the histological diagnosis of H pylori infection. Hematoxylin-eosin staining was used for the histological diagnosis of gastric mucosa inflammation, gastric glandular atrophy and intestinal metaplasia and scored into four grades according to the Updated Sydney System.RESULTS: The overall prevalence of H pylori infection in superficial gastritis was 28.7%, in erosive gastritis 57.7%,in gastric erosion 63.3%, in gastric ulcer 80.8%, in early gastric cancer 52.4%. There was significant difference (P<0.05), except for the difference between early gastric cancer and erosive gastritis. H pylori infection rate in antrum, corpus, angulus of patients with superficial gastritis was 25.9%, 26.2%, 25.2%, respectively; in patients with erosive gastritis 46.9%, 53.5%, 49.0%,respectively; in patients with gastric erosion 52.4%, 61.5%,52.4%, respectively; in patients with gastric ulcer 52.4%,61.5%, 52.4%, respectively; in patients with early gastric cancer 35.0%, 50.7%, 34.6%, respectively. No significant difference was found among the different site biopsies in superficial gastritis, but in the other diseases the detected rates were higher in corpus biopsy (P<0.05). The grades of mononuclear cell infiltration and polymorphonuclear cell infiltration, in early gastric cancer patients, were significantly higher than that in superficial gastritis patients, lower than that in gastric erosion and gastric ulcer patients (P<0.01);however, there was no significant difference compared with erosive gastritis. The grades

  13. Effective Treatments of Atrophic Acne Scars

    OpenAIRE

    Gozali, Maya Valeska; ZHOU, BINGRONG

    2015-01-01

    Atrophic scarring is often an unfortunate and permanent complication of acne vulgaris. It has high prevalence, significant impact on quality of life, and therapeutic challenge for dermatologists. The treatment of atrophic acne scars varies depending on the types of acne scars and the limitations of the treatment modalities in their ability to improve scars. Therefore, many options are available for the treatment of acne scarring, including chemical peeling, dermabrasion, laser treatment, punc...

  14. High frequency of helicobacter negative gastritis in patients with Crohn's disease.

    OpenAIRE

    Halme, L; Kärkkäinen, P; Rautelin, H; Kosunen, T. U.; Sipponen, P.

    1996-01-01

    The frequency of gastric Crohn's disease has been considered low. This study was undertaken to determine the prevalence of chronic gastritis and Helicobacter pylori infection in patients with Crohn's disease. Oesophagogastroduodenoscopy was performed on 62 consecutive patients suffering from ileocolonic Crohn's disease. Biopsy specimens from the antrum and corpus were processed for both histological and bacteriological examinations. H pylori antibodies of IgG and IgA classes were measured in ...

  15. Effective Corpus Virtualization

    OpenAIRE

    Jakubíček Miloš; Rychlý Pavel; Kilgarriff Adam

    2014-01-01

    In this paper we describe an implementation of corpus virtualization within the Manatee corpus management system. Under corpus virtualization we understand logical manipulation with corpora or their parts grouping them into new (virtual) corpora. We discuss the motivation for such a setup in detail and show space and time efficiency of this approach evaluated on a 11 billion word corpus of Spanish.

  16. Old Persian corpus

    NARCIS (Netherlands)

    M. Bavant

    2011-01-01

    XML Old Persian corpus. The corpus is based on publicly available data on the Web. Those data can be traced back to the grammar of Old Persian by Kent (1950). The corpus contains those data and is arranged in a way suitable for corpus searches.

  17. Superoxide dismutases in chronic gastritis.

    Science.gov (United States)

    Švagelj, Dražen; Terzić, Velimir; Dovhanj, Jasna; Švagelj, Marija; Cvrković, Mirta; Švagelj, Ivan

    2016-04-01

    Human gastric diseases have shown significant changes in the activity and expression of superoxide dismutase (SOD) isoforms. The aim of this study was to detect Mn-SOD activity and expression in the tissue of gastric mucosa, primarily in chronic gastritis (immunohistochemical Helicobacter pylori-negative gastritis, without other pathohistological changes) and to evaluate their possible connection with pathohistological diagnosis. We examined 51 consecutive outpatients undergoing endoscopy for upper gastrointestinal symptoms. Patients were classified based on their histopathological examinations and divided into three groups: 51 patients (archive samples between 2004-2009) with chronic immunohistochemical Helicobacter pylori-negative gastritis (mononuclear cells infiltration were graded as absent, moderate, severe) divided into three groups. Severity of gastritis was graded according to the updated Sydney system. Gastric tissue samples were used to determine the expression of Mn-SOD with anti-Mn-SOD Ab immunohistochemically. The Mn-SOD expression was more frequently present in specimens with severe and moderate inflammation of gastric mucosa than in those with normal mucosa. In patients with normal histological finding, positive immunoreactivity of Mn-SOD was not found. Our results determine the changes in Mn-SOD expression occurring in the normal gastric mucosa that had undergone changes in the intensity of chronic inflammatory infiltrates in the lamina propria. PMID:26765960

  18. Can chronic gastritis cause an increase in fecal calprotectin concentrations?

    Institute of Scientific and Technical Information of China (English)

    Massimo; Montalto; Antonella; Gallo; Gianluca; Ianiro; Luca; Santoro; Ferruccio; D; Onofrio; Riccardo; Ricci; Giovanni; Cammarota; Marcello; Covino; Monica; Vastola; Antonio; Gasbarrini; Giovanni; Gasbarrini

    2010-01-01

    AIM:To evaluate fecal calprotectin concentrations(FCCs) in subjects with chronic gastritis and the correlation between FCCs and gastritis activity score.METHODS:FCCs were measured in 61 patients with histological diagnosis of gastritis and in 74 healthy volunteers.Histological grading of gastritis was performed according to the updated Sydney gastritis classification.Patients were subdivided into 2 groups according to the presence/absence of an active gastritis.Patients with chronic active gastritis were di...

  19. Introduction to Dr. ZHAO Guo-cen's Experience in Treating Chronic Atrophic Gastritis

    Institute of Scientific and Technical Information of China (English)

    ZHAO Yi; YU Yue-juan; XIAO Yuan-chun

    2005-01-01

    @@ ZHAO Guo-cen, a senior doctor born in 1937, is a member of China Association of Traditional Chinese Medicine and one of the 500 well-known supervisors qualified to instruct disciples. He was born into a Chinese medicine family and has been engaging himself in the treatment of digestive disorders. He is an expert at internal medicine and acupuncture. His main clinical experience is summarized as "Nourishing spleen and stomach to treat digestive disorders, nourishing spleen and kidneys to treat diabetes mellitus, supplementing heart-qi and activating stagnated blood to treat chest distress, and restoring kidney-qi and balancing yin and yang to treat infertility."

  20. Localised Skin Hyperpigmentation as a Presenting Symptom of Vitamin B12 Deficiency Complicating Chronic Atrophic Gastritis

    OpenAIRE

    Kawther El-Shafie; Nafisa Samir; Ritu Lakhtakia; Robin Davidson; Ahmed Al-Waili; Muna Al-Mamary; Mohammed Al-Shafee

    2015-01-01

    Vitamin B12 deficiency is common in developing countries and should be suspected in patients with unexplained anaemia or neurological symptoms. Dermatological manifestations associated with this deficiency include skin hyper- or hypopigmentation, angular stomatitis and hair changes. We report a case of a 28-year-old man who presented to the Sultan Qaboos University Hospital in Muscat, Oman, in November 2013 with localised hyperpigmentation of the palmar and dorsal aspects of both hands of two...

  1. Vitamin C, gastritis, and gastric disease: a historical review and update.

    Science.gov (United States)

    Aditi, Anupam; Graham, David Y

    2012-10-01

    The discovery of Helicobacter pylori as the cause of gastritis and peptic ulcers ushered in the modern era of research into gastritis and into acid-peptic diseases and rekindled interest in the role of ascorbic acid in the pathophysiology and treatment of gastritis and peptic ulcer disease. Here, we review historic and modern studies on ascorbic acid and gastric diseases with an emphasis on H. pylori gastritis and its sequelae. The relationship of ascorbic acid and gastritis and peptic ulcer and its complications was extensively studied during the 1930s through the 1950s. Much of this extensive literature has been effectively "lost." Ascorbic acid deficiency was associated with all forms of gastritis (e.g., autoimmune, chemical, and infectious) due in varying degrees to insufficient intake, increased metabolic requirements, and destruction within the GI tract. Importantly, gastritis-associated abnormalities in gastric ascorbic acid metabolism are reversed by H. pylori-eradication and potentially worsened by proton pump inhibitor therapy. Diets rich in naturally occurring ascorbic acid are associated with protection of the gastric corpus from atrophy and a reduction in the incidence of gastric cancer possibly through the ability of ascorbic acid to reduce oxidative damage to the gastric mucosa by scavenging carcinogenic N-nitroso compounds and free radicals and attenuating the H. pylori-induced inflammatory cascade. Ascorbic acid supplementation was possibly associated with a decreased incidence of bleeding from peptic ulcer disease. Pharmacologic doses of ascorbic acid also may improve the effectiveness of H. pylori-eradication therapy. Occasionally, looking back can help plot the way forward. PMID:22543844

  2. Corpus Linguistics Facilitates English Teaching

    Institute of Scientific and Technical Information of China (English)

    朱思亲

    2014-01-01

    Corpus linguistics has been widely applied in English teaching. Corpus linguistics has changed the way to teach English. The essay discusses two approaches in English teaching based on corpus, corpus-driven approach and corpus-based approach. It finds out that both corpus-driven approach and corpus-based approach facilitate English teaching in their own ways.

  3. Lymphocytic gastritis--prospective study of its relationship with varioliform gastritis.

    OpenAIRE

    Haot, J; Jouret, A.; Willette, M; Gossuin, A; Mainguet, Paul

    1990-01-01

    Lymphocytic gastritis is a new histopathological entity characterised by a dense lymphocytic infiltration of surface and pit gastric epithelium. Previous retrospective work has suggested that lymphocytic gastritis is related to an endoscopic form of gastropathy comprising enlarged folds, nodules and erosions, commonly denoted as varioliform gastritis. In the present prospective study, the relationship is clearly shown; nearly 82% (54/66) of the varioliform gastritis observed in four different...

  4. Acute gastritis-induced Takotsubo's cardiomyopathy

    OpenAIRE

    Villablanca, Pedro A.; Sukhal, Shashvat; Ansari, Asimul; Mohammed, Dergham

    2013-01-01

    Key Clinical Message A 50-year-old lady presented with epigastralgia, electrocardiogram (ECG) showed T-wave inversions and the echocardiogram low ejection fraction (EF) with apical ballooning. An esophagogastroduodenoscopy (EGD) revealed gastritis. She recovered with proton pump inhibitors treatment. This is the first case that describes gastritis-induced stress cardiomyopathy. Clinicians should be aware of Takotsubo's cardiomyopathy (TCM) as a possible complication of gastritis.

  5. Can chronic gastritis cause an increase in fecal calprotectin concentrations?

    OpenAIRE

    Massimo Montalto, Antonella Gallo, Gianluca Ianiro, Luca Santoro, Ferruccio D’Onofrio, Riccardo Ricci, Giovanni Cammarota, Marcello Covino, Monica Vastola, Antonio Gasbarrini, Giovanni Gasbarrini

    2010-01-01

    AIM: To evaluate fecal calprotectin concentrations (FCCs) in subjects with chronic gastritis and the correlation between FCCs and gastritis activity score.METHODS: FCCs were measured in 61 patients with histological diagnosis of gastritis and in 74 healthy volunteers. Histological grading of gastritis was performed according to the updated Sydney gastritis classification. Patients were subdivided into 2 groups according to the presence/absence of an active gastritis. Patients with chronic act...

  6. Microneedling Therapy for Atrophic Acne Scars

    Science.gov (United States)

    Barakat, Manal; Awad, Sherif; Medhat, Walid; El-Fakahany, Hasan; Farag, Hanna

    2015-01-01

    Objective: Treatment of acne scarring is always a challenge. Microneedling therapy or percutaneous collagen induction is a new addition to the treatment modalities for such scars and has been reported to be simple and effective in atrophic acne scar treatment. The aim of this study is to evaluate the clinical effect and objectively quantify the histological changes of acne scarring in response to skin microneedling. Design: A prospective clinical study. Participants: Ten patients with different types of atrophic acne scars were subjected to three months of skin microneedling treatment (six sessions at two-week intervals). Measurements: Patients were photographed, and skin biopsies were obtained at baseline as well as one and three months from the start of treatment. Histometry for epidermal thickness and quantitative evaluation of total elastin; newly synthesized tropoelastin; collagen types I, III, and VII; and newly synthesized collagen were performed for all biopsies. Results: Compared to the baseline, patients’ evaluations revealed noticeable clinical improvement in atrophic post-acne scars in response to skin microneedling. There was a statistically significant increase (pmicroneedling are an effective treatment for post-acne atrophic scars as it stimulates the repair processes with the advantage of being a relatively risk-free, in-office procedure with minimal patient recovery time. PMID:26203319

  7. Corpus et stylistique

    OpenAIRE

    Magri-Mourgues, Véronique

    2007-01-01

    Une question lancée comme un défi a sous-tendu ce numéro de Corpus. Parallèlement aux linguistiques de corpus qui commencent à être clairement établies, serait-il envisageable de définir une stylistique de corpus ? Ou bien formulé autrement, que peut être un corpus pertinent en stylistique ? Quelles sont ses spécificités, si elles existent ? Articulant la problématique du corpus et l’analyse stylistique, les contributeurs explorent ce faisant des enjeux épistémologiques qui font envisager un ...

  8. Phlegmonous Gastritis Following Coronary Bypass Surgery

    OpenAIRE

    Radhi, J; Kamouna, M; Nyssen, J.

    1999-01-01

    Phlegmonous gastritis is a rare, rapidly progressive and potentially fatal gastric bacterial infection. A case of phlegmonous gastritis following a coronary bypass surgery is described. This condition was not diagnosed premortem due to the nonspecific nature of the gastrointestinal symptoms. Upper gastrointestinal endoscopy may be of value in establishing the diagnosis in emergencies with culture of gastric aspirate and biopsy.

  9. Hubungan TNF-α dengan Derajat Keparahan Gastritis

    OpenAIRE

    Siregar, Gontar Alamsyah; Sitepu, Ricky Rivalino; Halim, Sahat

    2016-01-01

    Gastritis ialah proses peradangan pada lapisan mukosa dan submukosa lambung sebagai respon terhadap jejas (injury). Gastritis berbeda dengan dispepsia, yang merupakan suatu sindroma klinis. Sementara gastritis merupakan diagnosis yang bisa ditegakkan secara histologis, bukan secara klinis. Pada gastritis terjadi respons inflamasi baik akut maupun kronik dimana faktor-faktor proinflamasi, atau disebut dengan sitokin, teraktivasi dan menyebabkan terjadinya inflamasi mukosa. Infeksi dengan k...

  10. Gastritis

    Science.gov (United States)

    ... hands with soap and water after using the bathroom and before eating eat food that has been ... La Información de la Salud en Español Health Statistics Healthy Moments Radio Broadcast Clinical Trials For Health ...

  11. Gastritis

    Science.gov (United States)

    ... with a bacteria called Helicobacter pylori Less common causes are: Autoimmune disorders (such as pernicious anemia) Backflow of bile into the stomach (bile reflux) Cocaine abuse Eating or drinking caustic or corrosive substances (such as ...

  12. Emphysematous gastritis: case report and literature review

    International Nuclear Information System (INIS)

    Emphysematous gastritis is a rare form of gastritis that results from infection of the stomach wall by gas-forming organisms. Diagnosis of this commonly fatal condition rests on radiological demonstration of gas within the stomach wall. This can be observed on plain radiographs or CT scans of the abdomen. Only by prompt diagnosis and treatment can mortality be avoided. A new case of empysematous gastritis, diagnosed on CT scan by the demonstration of both intramural and portal venous gas, is presented and the literature is reviewed. Copyright (2001) Blackwell Science Pty Ltd

  13. Hypertrophic gastropathy with gastric adenocarcinoma: Menetrier's disease and lymphocytic gastritis?

    OpenAIRE

    Mosnier, J F; Flejou, J F; Amouyal, G; Gayet, B; Molas, G.; Henin, D; Potet, F

    1991-01-01

    Lymphocytic gastritis is a form of gastric inflammation characterised by a pronounced increase in lymphocytes in gastric surface and foveolar epithelium. Lymphocytic gastritis is often associated with endoscopic evidence of 'varioliform gastritis'. Lymphocytic gastritis has recently been reported to be associated with other forms of hypertrophic gastropathies. We present a case of hypertrophic gastropathy with gastric adenocarcinoma, with both Menetrier's disease and lymphocyte gastritis. Imm...

  14. Chronic Gastritis in Morbidly Obese Patients with Sleeve Gastrectomy

    OpenAIRE

    Makki, Ahmed Mohammad; Aldaqal, Saleh Mohammad; Alorabi, Shahad Hamadan; Nemri, Ismail Ahmed; Alajami, Maha Mohammad

    2016-01-01

    Introduction Obesity is a condition that has significant impact on public health. Recent exciting studies have linked chronic gastritis and H. pylori infection to obesity. Chronic gastritis has shown increased prevalence in obesity, more particularly H. pylori-related gastritis. This study aimed to determine the prevalence of chronic gastritis in morbidly obese patients who were subjected to sleeve gastrectomy, with focus on H. pylori-related gastritis. The aim was to demonstrate any influenc...

  15. Combination Therapy in the Management of Atrophic Acne Scars

    OpenAIRE

    Shilpa Garg; Sukriti Baveja

    2014-01-01

    Background: Atrophic acne scars are difficult to treat. The demand for less invasive but highly effective treatment for scars is growing. Objective: To assess the efficacy of combination therapy using subcision, microneedling and 15% trichloroacetic acid (TCA) peel in the management of atrophic scars. Materials and Methods: Fifty patients with atrophic acne scars were graded using Goodman and Baron Qualitative grading. After subcision, dermaroller and 15% TCA peel were performed alternatively...

  16. Mucosal pattern in the diagnosis of gastritis

    International Nuclear Information System (INIS)

    To assess the sensitivity of radiology in diagnosis of gastritis within 2 hours endoscopy and biopsy of the stomach and double contrast barium meal were performed. The diagnosis was established of the morphologic picture of the areae gastricae, which were sufficient visible in 33 out of 50 cases (66%). In 7 patients radiologic findings were normal, 13 patients showed superficial gastritis, 10 patients had superficial gastritis with signs of atrophy and in 3 patients there was an erosive gastritis. In all 33 patients (100%) there was a complete correlation of radiologic and endoscopic findings, in 24 out of 33 cases (73%) even correlation between radiologic and histologic classification. These results are discussed and confrontated with literatures. (orig.)

  17. Gastritis cystica profunda : a case report

    Energy Technology Data Exchange (ETDEWEB)

    Shim, Joo Eun; Kim, Ho Chul; Bae, Sang Hoon; Cho, So Yeon [Hallym Univ. College of Medicine, Chunchon (Korea, Republic of)

    1997-05-01

    Gastritis cystica profunda is an uncommon benign mass that usually occurs on the gastric side of the site of a gastroenterostomy, but has also been known to develop in which has not been operated on. We report the case of stomach a 51-years-old man with pathologically proven gastritis cystica profunda. This patient had not undergone gastric surgery CT showed a well-defined, 3cm sized, cystic mass at the gastric antrum.

  18. Gastritis cystica profunda : a case report

    International Nuclear Information System (INIS)

    Gastritis cystica profunda is an uncommon benign mass that usually occurs on the gastric side of the site of a gastroenterostomy, but has also been known to develop in which has not been operated on. We report the case of stomach a 51-years-old man with pathologically proven gastritis cystica profunda. This patient had not undergone gastric surgery CT showed a well-defined, 3cm sized, cystic mass at the gastric antrum

  19. Therapeutic effect of Streptococcus thermophilus CRL 1190-fermented milk on chronic gastritis

    Directory of Open Access Journals (Sweden)

    Cecilia Rodríguez, Marta Medici, Fernanda Mozzi, Graciela Font de Valdez

    2010-04-01

    Full Text Available AIM: To investigate the potential therapeutic effect of exopolysaccharide (EPS-producing Streptococcus thermophilus (S. thermophilus CRL 1190 fermented milk on chronic gastritis in Balb/c mice.METHODS: Balb/c mice were fed with the fermented milk for 7 d after inducing gastritis with acetyl-salicylic acid (ASA, 400 mg/kg body weight per day for 10 d. Omeprazole was included in this study as a positive therapeutic control. The gastric inflammatory activity was evaluated from gastric histology and inflammation score, number of interleukin-10 (IL-10, interferon-γ (INFγ and tumor necrosis factor-α (TNF-α cytokine-producing cells in the gastric mucosa, and thickness of the mucus layer.RESULTS: Animals receiving treatment with the EPS-producing S. thermophilus CRL 1190 fermented milk showed a conserved gastric mucosa structure similar to that of healthy animals. Inflammation scores of the fermented milk-treated mice were lower than those of mice in the gastritis group (0.2 ± 0.03 vs 2.0 ± 0.6, P < 0.05. A marked decrease in INFγ+ (15 ± 1.0 vs 28 ± 1.2, P < 0.05 and TNF-α+ (16 ± 3.0 vs 33 ± 3.0, P < 0.05 cells and an increase in IL-10+ (28 ± 1.5 vs 14 ± 1.3, P < 0.05 cells compared to the gastritis group, was observed. Also, an increase in the thickness of the mucus gel layer (2.2 ± 0.6 vs 1.0 ± 0.3; 5.1 ± 0.8 vs 1.5 ± 0.4 in the corpus and antrum mucosa, respectively, P < 0.05 compared with the gastritis group was noted. A milk suspension of the purified EPS from S. thermophilus CRL1190 was also effective as therapy for gastritis.CONCLUSION: This study suggests that fermented milk with S. thermophilus CRL 1190 and/or its EPS could be used in novel functional foods as an alternative natural therapy for chronic gastritis induced by ASA.

  20. Gastric Lipase Secretion in Children with Gastritis

    Directory of Open Access Journals (Sweden)

    Krystyna Sztefko

    2013-07-01

    Full Text Available Gastric lipase is one of the prepancreatic lipases found in some mammalian species and in humans. Our knowledge of the hormonal regulation of gastric lipase secretion in children and adolescents is still very limited. The aim of this study was to compare the activity of human gastric lipase (HGL in gastric juice in healthy adolescents and in patients with gastritis. The adolescents were allocated to three groups: the first including patients with Helicobacter pylori gastritis (HPG; n = 10, the second including patients with superficial gastritis caused by pathogens other than H. pylori (non-HPG; n = 14 and the control group including healthy adolescents (n = 14. Activity of HGL was measured in gastric juice collected during endoscopy. Plasma concentrations of cholecystokinin (CCK, glucagon-like peptide-1 (GLP-1 and glucose-dependent insulinotropic peptide (GIP were measured in all adolescents. Activity of HGL in the non-HPG group was significantly lower than in the HPG group (p < 0.005 and the control group (p < 0.005. Mean plasma GIP levels in the control group were lower than in the non-HPG group (p < 0.003 and the HPG group (p < 0.01. We conclude that the regulation of HGL secretion by GLP-1 and CCK is altered in patients with gastritis. Moreover, GIP is a potent controller of HGL activity, both in healthy subjects and in patients with gastritis.

  1. Preventive effects of geranylgeranylacetone on rat ethanol-induced gastritis

    OpenAIRE

    Ning, Jian-Wen; Lin, Guan-Bin; Ji, Feng; Xu, Jia; Sharify, Najeeb

    2012-01-01

    AIM: To establish a rat ethanol gastritis model, we evaluated the effects of ethanol on gastric mucosa and studied the preventive effects of geranylgeranylacetone on ethanol-induced chronic gastritis.

  2. Epithelial cell proliferation in human fundic and antral mucosae. Influence of superselective vagotomy and relationship with gastritis

    International Nuclear Information System (INIS)

    Epithelial cell proliferation in the fundic and antral mucosae was studied in 19 duodenal ulcer patients, 11 patients having undergone fundic superselective vagotomy for duodenal ulcer, and 10 controls. This was achieved through in vitro incorporation of tritiated thymidine in mucosal biopsies and radioautography. Except for increased fundic mucosal height, duodenal ulcer patients did not differ from controls for all parameters studied. In vagotomized patients, as compared to the other two groups, the labeling index was significantly enhanced in the innervated antral mucosa where atrophic gastritis developed, but there was no change in the labeling index and no worsening of mucosal inflammation in the denervated fundic mucosa. The only abnormality in the latter was a striking expansion, towards the surface, of the proliferative area within the fundic pit. The labeling indices and the degree of gastritis in gastric mucosae are significantly correlated in control and duodenal ulcer patients. If findings in antral mucosa, after superselective vagotomy, seemed related to gastritis lesions, those in fundic mucosa were not and may indicate an alteration due to the vagotomy per se

  3. Prevalence of H pylori associated 'high risk gastritis' for development of gastric cancer in patients with normal endoscopic findings

    Institute of Scientific and Technical Information of China (English)

    Andreas Leodolter; Matthias P Ebert; Ulrich Peitz; Kathlen Wolle; Stefan Kahl; Michael Vieth; Peter Malfertheiner

    2006-01-01

    AIM: To investigate the prevalence of H pylori associated corpus-predominant gastritis (CPG) or pangastritis, severe atrophy, and intestinal metaplasia (IM) in patients without any significant abnormal findings during upper GI endoscopy.METHODS: Gastric biopsies from 3548 patients were obtained during upper GI-endoscopy in a 4-year period. Two biopsies from antrum and corpus were histologically assessed according to the updated Sydney-System.Eight hundred and forty-five patients (mean age 54.8 ±2.8 years) with H pylori infection and no peptic ulcer or abnormal gross findings in the stomach were identified and analyzed according to gastritis phenotypes using different scoring systems.RESULTS: The prevalence of severe H pylori associated changes like pangastritis, CPG, IM, and severe atrophy increased with age, reaching a level of 20% in patients of the age group over 45 years. No differences in frequencies between genders were observed. The prevalence of IM had the highest increase, being 4-fold higher at the age of 65 years versus in individuals less than 45 years.CONCLUSION: The prevalence of gastritis featuring at risk for cancer development increases with age. These findings reinforce the necessity for the histological assessment, even in subjects with normal endoscopic appearance. The age-dependent increase in prevalence of severe histopathological changes in gastric mucosa, however, does not allow estimating the individual risk for gastric cancer development-only a proper follow-up can provide this information.

  4. Corpus Design for Malay Corpus-based Speech Synthesis System

    Directory of Open Access Journals (Sweden)

    Tian-Swee Tan

    2009-01-01

    Full Text Available Problem statement: Speech corpus is one of the major components in corpus-based synthesis. The quality and coverage in speech corpus will affect the quality of synthesis speech sound. Approach: This study proposes a corpus design for Malay corpus-based speech synthesis system. This includes the study of design criteria in corpus-based speech synthesis, Malay corpus based database design and the concatenation engine in Malay corpus-based synthesis system. A set of 10 millions digital text corpuses for Malay language has been collected from Malay internet news. This text corpus had been analyzed using word frequency count to find out all high frequency words to be used for designing the sentences for speech corpus. Results: Altogether 381 sentences for speech corpus had been designed using 70% of high frequency words from 10 million text corpus. It consists of 16826 phoneme units and the total storage size is 37.6Mb. All the phone units are phonetically transcribed to preserve the phonetic context of its origin that will be used for phonetic context unit. This speech corpus had been labeled at phoneme level and used for variable length continuous phoneme based concatenation. Speech corpus is one of the major components in corpus-based synthesis. The quality and coverage in speech corpus will affect the quality of synthesized speech sound. Conclusion/Recommendation: This study has proposed a platform for designing speech corpus especially for Malay Text to Speech which can be further enhanced to support more coverage and higher naturalness of synthetic speech.

  5. A Rare Cause of Stomach Gangrene: Necrotizing Gastritis

    OpenAIRE

    Hicham El Bouhaddouti; Tarik Souiki; Khalid Mazine; Abdelmalek Ousadden; Khalid Mazaz; Khalid Ait Taleb

    2015-01-01

    Necrosis of the stomach is rare. It occurs when there is vascular anomalies, gastric volvulus or her-niation and in infectious gastritis. We report a case in which infectious gastritis leads to a necrotiz-ing gastritis that is treated with urgent gastrectomy.

  6. [Case of scattered gastritis associated with ulcerative proctitis].

    Science.gov (United States)

    Ozawa, Toshifumi; Wachi, Eiko; Saitoh, Yasutoshi

    2009-01-01

    A 59-year-old man who had ulcerative proctitis for 18 years visited our hospital because of stomach pain. Proctitis had been in remission stage for five recent years by the mesalazine administration. Esophagogastroduodenoscopy (EGD) showed scattered patchy erosions at the corpus of the stomach. Anti-acid secretory agents was administrated, however, erosive change worsened in multiplicity and in area. Biopsied specimen of gastric mucosa showed specific findings resembling to cryptitis, crypt abcess and focally enhanced gastritis. H. pylori infection was negative by some examinations. Our patient had no history of taking non steroidal anti-inflammatory drugs (NSAIDs) so far. From the findings above, it was considered that gastric lesion was strongly related to the ulcerative proctitis. 5-aminosalicylic acid (750 mg, three times daily) ground to powder was administered with predonisolon (20 mg, once daily). Five month later, all the erosions disappeared completely on EGD and biopsied specimen revealed a reduction of inflammatory cells. The present case has a rare gastric lesion with patchy pattern (not diffuse pattern) which is strongly associated with ulcerative proctitis. PMID:19122423

  7. Effects of bile reflux on gastric mucosal lesions in patients with dyspepsia or chronic gastritis

    Institute of Scientific and Technical Information of China (English)

    Sheng-Liang Chen; Jian-Zhong Mo; Zhi-Jun Cao; Xiao-Yu Chen; Shu-Dong Xiao

    2005-01-01

    AIM: To investigate the influences of bile reflux on profiles of gastric mucosal lesions in patients with dyspepsia or chronic gastritis.METHODS: A total of 49 patients diagnosed with dyspepsia and chronic gastritis underwent 24-h ambulatory andsimultaneous monitoring of intragastric bilirubin absorbance and pH values, and then they were divided into bile refluxpositive group and bile reflux negative group. Severity of pathological changes in gastric mucosa including activeinflammation, chronic inflammation, intestinal metaplasia, atrophy and dysplasia as well as Helicobacter pylori (H pylori) infection at the corpus, incisura and antrum were determined respectively according to update Sydney system criteria. The profiles of gastric mucosal lesions in the two groups were compared, and correlations between time-percentage of gastric bilirubin absorbance >0.14 and severity of gastric mucosal lesions as well as time-percentage of gastric pH >4 were analyzed respectively. RESULTS: Thirty-eight patients (21 men and 17 women, mean age 44.2 years, range 25-61 years) were found existing with bile reflux (gastric bilirubin absorbance >0.14) and 11 patients (7 men and 4 women, mean age 46.2 years,range 29-54 years) were bile reflux negative. In dyspepsia patients with bile reflux, the mucosal lesions such as active inflammation, chronic inflammation, intestinal metaplasia, atrophy or H pylori infection in the whole stomach, especially in the corpus and incisura, were significantly more severe than those in dyspepsia patients without bile reflux. Moreover, the bile reflux time was well correlated with the severity of pathological changes of gastric mucosa as well as H pylori colonization in the near-end stomach, especially in the corpus region. No relevance was found between the time of bile reflux and pH >4 in gastric cavity. CONCLUSION: Bile reflux contributes a lot to mucosal lesions in the whole stomach, may facilitate H pylori colonization in the corpus region

  8. Can chronic gastritis cause an increase in fecal calprotectin concentrations?

    Science.gov (United States)

    Montalto, Massimo; Gallo, Antonella; Ianiro, Gianluca; Santoro, Luca; D’Onofrio, Ferruccio; Ricci, Riccardo; Cammarota, Giovanni; Covino, Marcello; Vastola, Monica; Gasbarrini, Antonio; Gasbarrini, Giovanni

    2010-01-01

    AIM: To evaluate fecal calprotectin concentrations (FCCs) in subjects with chronic gastritis and the correlation between FCCs and gastritis activity score. METHODS: FCCs were measured in 61 patients with histological diagnosis of gastritis and in 74 healthy volunteers. Histological grading of gastritis was performed according to the updated Sydney gastritis classification. Patients were subdivided into 2 groups according to the presence/absence of an active gastritis. Patients with chronic active gastritis were divided into 3 subgroups on the basis of the activity score (mild, moderate, marked). FFCs in relation to Helicobacter pylori (H. pylori) infection and proton pump inhibitor (PPI) use were also evaluated. RESULTS: FCCs in patients with chronic active gastritis were not significantly different to FCCs either in subjects with non active gastritis or in healthy controls. Among patients with chronic active gastritis (even marked), FCCs did not significantly differ according to activity score. No significant differences in FCCs were found when considering H. pylori, as well as when considering PPI chronic use. CONCLUSION: FCCs were not significantly increased in subjects with chronic gastritis, even in those patients with a marked neutrophil infiltration. PMID:20632443

  9. [Unpleasant Journey from Helicobacter pylori-associated Gastritis to Gastric Cancer: Cancer Prevention by Taking a Detour].

    Science.gov (United States)

    Lee, Sang Hwan; Park, Jong Min; Han, Young Min; Ko, Weon Jin; Hahm, Ki Baik

    2015-12-01

    As a commensal or a pathogen, Helicobacter pylori can change the balance of a complex interaction that exists among gastric epithelial cells, microbes, and their environment. Therefore, unraveling this complex relationship of these mixtures can be expected to help prevent cancer as well as troublesome unmet medical needs of H. pylori infection. Though gastric carcinogenesis is a multi-step process, precancerous lesion can be reversible in the early phase of mucosal damage before reaching the stage of no return. However, biomarkers to predict rejuvenation of precancerous atrophic gastritis have not been identified yet and gastric cancer prevention is still regarded as an impregnable fortress. However, when we take the journey from H. pylori-associated gastritis to gastric cancer, it provides us with the clue for prevention since there are two main preventive strategies: eradication and anti-inflammation. The evidence supporting the former strategy is now ongoing in Japan through a nation-wide effort to eradicate H. pylori in patients with chronic gastritis, but suboptimal apprehension to increasing H. pylori resistance to antibiotics and patient non-compliance still exists. The latter strategy has been continued in the author'sresearch center under siTRP (short-term intervention to revert premalignant lesion) strategy. By focusing on the role of inflammation in the development of H. pylori-associated gastric carcinogenesis, this review is intended to explain the connection between inflammation and gastric cancer. Strategies on H. pylori eradication, removal of inflammation, and reverting preneoplastic lesion will also be introduced. In the end, we expect to be able to prevent gastric cancer by take a detour from the unpleasant journey, i.e. from H. pylori-associated gastritis to gastric cancer. PMID:26691187

  10. Histopathological profile of gastritis in adult patients seen at a referral hospital in Kenya

    Institute of Scientific and Technical Information of China (English)

    Ahmed Kalebi; Farzana Rana; Walter Mwanda; Geoffrey Lule; Martin Hale

    2007-01-01

    AIM: To conduct a detailed histological study of gastritis in adult patients attending an endoscopy clinic at a Kenyan teaching and referral hospital.METHODS: Biopsy specimens from consecutive patients were examined and graded according to the Updated Sydney System for H pylori infection, chronic inflammation, neutrophil activity, glandular atrophy and intestinal metaplasia. Also documented were gastric tissue eosinophil counts and presence of lymphoid follicles.RESULTS: The rate of the graded variables, in the antrum and corpus respectively, were as follows:H pylori infection (91%, 86%), chronic inflammation (98%, 93%),neutrophil activity (91%, 86%), glandular atrophy (57%,15%) and intestinal metaplasia (11%, 2%). Lymphoid follicles were noted in 11% of cases. Duodenal and gastric ulcers were documented in 32% and 2% respectively.The mean eosinophil count was 5.9 ± 0.74 eosinophils/HPF and 9.58 ± 0.93 eosinophils/HPF in the corpus and antrum respectively. Significant association was found between the degree of H pylori colonisation with chronic inflammation, neutrophil activity and antral glandular atrophy. Biopsies from the antrum and corpus showed significant histopathological discordance for all the graded variables.H pylori negative cases were associated with recent antibiotic use.CONCLUSION: The study reaffirms that H pylori is the chief cause of gastritis in this environment. The majority of patients show a moderate to high degree of inflammation but a low degree of glandular atrophy and intestinal metaplasia. The study shows that interrelationships between the histological variables in this African population are similar to those found in other populations worldwide including non-African populations.

  11. Microneedling Therapy in Atrophic Facial Scars: An Objective Assessment

    OpenAIRE

    Majid Imran

    2009-01-01

    Background: Atrophic facial scars are always a challenge to treat, especially the ones that are deep-seated and/or involve much of the face. Microneedling or dermaroller therapy is a new addition to the treatment armamentarium for such scars that offers a simple and reportedly effective management of these scars. Aims: The aim of the present study was to perform an objective evaluation of the efficacy of dermaroller treatment in atrophic facial scars of varying etiology. Materials and Met...

  12. Enhanced M1 Macrophage Polarization in Human Helicobacter pylori-Associated Atrophic Gastritis and in Vaccinated Mice

    OpenAIRE

    Quiding-Järbrink, Marianne; Raghavan, Sukanya; Sundquist, Malin

    2010-01-01

    Background Infection with Helicobacter pylori triggers a chronic gastric inflammation that can progress to atrophy and gastric adenocarcinoma. Polarization of macrophages is a characteristic of both cancer and infection, and may promote progression or resolution of disease. However, the role of macrophages and their polarization during H. pylori infection has not been well defined. Methodology/Principal Findings By using a mouse model of infection and gastric biopsies from 29 individuals, we ...

  13. Atrophic gastric changes in both Helicobacter felis and Helicobacter pylori infected mice are host dependent and separate from antral gastritis.

    OpenAIRE

    Sakagami, T; Dixon, M; O'Rourke, J; Howlett, R.; Alderuccio, F; Vella, J; Shimoyama, T; Lee, A.

    1996-01-01

    BACKGROUND/AIMS: The role of host factors has been neglected in studies of the pathogenesis of Helicobacter associated disease. The aim of this study was to assess the response of different mouse strains to infection with a single strain of Helicobacter felis. METHOD: Six strains of inbred mice were infected with the identical H felis culture and were killed at one month, two months, and six months after infection to assess histopathological changes. In addition, two strains of mice were infe...

  14. Explorations of Corpus Translation Studies

    Institute of Scientific and Technical Information of China (English)

    何琳琳

    2014-01-01

    Corpus-based translation studies belong to a new translation study paradigm which rose at the beginning of 1990s. The rise of corpus brings the update of research tools and research methods, and lead to the emerging of Corpus Translation Stud-ies. It is necessary to introduce the theory basis of Translational English Corpus and its application in the translation, especially in the science and technology translation. Besides, it makes an analysis and discussion about the potential of Corpus Translation Stud-ies.

  15. Predictive value of radiographic findings in gastritis

    International Nuclear Information System (INIS)

    In a retrospective review of biphasic upper gastrointestinal (GI) tract examinations in 300 consecutive patients with abdominal pain, blood loss, nausea and vomiting, weight loss or dysphagia, the author evaluated the frequency of radiographic findings suggestive of gastritis. Forty-eight patients had undergone endoscopy within 1 week of upper GI tract examination. ''Best findings'' were defined by receiver operating characteristic wave analysis of individual findings, including aphthous lesions, serrated or nodular folds, marginal spiculation, and luminal constriction. Most false negative studies were in the fundus or proximal body; most false positive studies were in the antrum. They present a pictorial dictionary of findings and data for use of ''best findings'' to improve sensitivity and specificity in the diagnosis of gastritis

  16. Role of zinc in chronic gastritis

    OpenAIRE

    Marjanović, Ksenija; Dovhanj, Jasna; Kljaić, Ksenija; Šakić, Katarina; Kondža, Goran; Tadžić, Refmir; Včev, Aleksandar

    2010-01-01

    Oxidative stress occurs in inflammation of gastric mucosa. The role of zinc in modulating oxidative stress has recently been recognized. Zn deficiency results in an increased sensitivity to oxidative stress and have a higher risk of musoca damage in inflammation. The aim of this study was to determine wheather chronic inflammation affects on the concentration of Zn2+ ions in gastric mucosa of patients with chronic gastritis. Forthy-three patients with chronic gastitis were enrolled. Patients ...

  17. Eosinophilic Gastritis Presenting as Tissue Necrosis

    OpenAIRE

    Jo, Yong Min; Jang, Jin Seok; Han, Seung Hee; Kang, Sang Hyun; Kim, Woo Jae; Jeong, Jin Sook

    2015-01-01

    Eosinophilic gastroenteritis is very rare disorder that is characterized by eosinophilic infiltration of the gastrointestinal tract in the absence of any definite causes of eosinophilia. It is associated with various clinical gastrointestinal manifestations, and depends on the involved layer and site. We report a case of eosinophilic gastritis presenting with severe necrosis. The symptoms disappeared immediately after beginning steroid treatment, and the eosinophil count decreased to the refe...

  18. Gastric gallium-67 uptake in gastritis

    International Nuclear Information System (INIS)

    Even though Ga-67 imaging has been used widely in the diagnosis of malignant as well as inflammatory lesions, its uptake in the stomach has been reported in the literature mainly in gastric lymphoma and carcinoma. As shown in this case, intense gastric uptake of the radionuclide may be seen in common gastritis without malignancy. Perhaps the benign gastric uptake of Ga-67 deserves more emphasis

  19. Malay Interrogative Knowledge Corpus

    Directory of Open Access Journals (Sweden)

    Fatimah Sidi

    2011-01-01

    Full Text Available Problem statement: The growth in the number of documents written in Malay language is enormously available on the web and intranets. There is a need to identify the information in the Malay documents that contain knowledge. This triggers the need to investigate the availability of knowledge in them. Approach: This study uses interrogative theory to identify knowledge from documents or texts. Results: The results are expected to lead towards establishment of new set of interrogative rules for Malay corpus. Conclusions/Recommendations: This study contributes the interrogative knowledge identification thru the development of Malay Interrogative Knowledge Corpus (MalayIKCorpus. It facilitates to explicitly capture and make available Malay knowledge representation in a knowledge-base system.

  20. Focused Web Corpus Crawling

    OpenAIRE

    Schäfer, Roland; Barbaresi, Adrien; Bildhauer, Felix

    2014-01-01

    International audience In web corpus construction, crawling is a necessary step, and it is probably the most costly of all, because it requires expensive bandwidth usage, and excess crawling increases storage requirements. Excess crawling results from the fact that the web contains a lot of redundant content (duplicates and near-duplicates), as well as other material not suitable or desirable for inclusion in web corpora or web indexes (for example, pages with little text or virtually no t...

  1. Atrophic Vaginitis in Breast Cancer Survivors: A Difficult Survivorship Issue

    Directory of Open Access Journals (Sweden)

    Joanne Lester

    2015-03-01

    Full Text Available Management of breast cancer includes systematic therapies including chemotherapy and endocrine therapy can lead to a variety of symptoms that can impair the quality of life of many breast cancer survivors. Atrophic vaginitis, caused by decreased levels of circulating estrogen to urinary and vaginal receptors, is commonly experienced by this group. Chemotherapy induced ovarian failure and endocrine therapies including aromatase inhibitors and selective estrogen receptor modulators can trigger the onset of atrophic vaginitis or exacerbate existing symptoms. Symptoms of atrophic vaginitis include vaginal dryness, dyspareunia, and irritation of genital skin, pruritus, burning, vaginal discharge, and soreness. The diagnosis of atrophic vaginitis is confirmed through patient-reported symptoms and gynecological examination of external structures, introitus, and vaginal mucosa. Lifestyle modifications can be helpful but are usually insufficient to significantly improve symptoms. Non-hormonal vaginal therapies may provide additional relief by increasing vaginal moisture and fluid. Systemic estrogen therapy is contraindicated in breast cancer survivors. Continued investigations of various treatments for atrophic vaginitis are necessary. Local estrogen-based therapies, DHEA, testosterone, and pH-balanced gels continue to be evaluated in ongoing studies. Definitive results are needed pertaining to the safety of topical estrogens in breast cancer survivors.

  2. Helicobacter pylori-negative Russell body gastritis: Case report

    OpenAIRE

    Gobbo, Alessandro Del; Elli, Luca; Braidotti, Paola; Nuovo, Franca Di; Bosari, Silvano; Romagnoli, Solange

    2011-01-01

    Russell body gastritis is an unusual form of chronic gastritis characterized by the permeation of lamina propria by numerous plasma cells with eosinophilic cytoplasmic inclusions. Very few cases have been reported in the literature; the majority of which have shown Helicobacter Pylori (H. pylori) infection, thus suggesting a correlation between plasma cell presence and antigenic stimulation by H. pylori. We present a case of Russell body gastritis in a 78-year-old woman who was undergoing eso...

  3. Kyoto global consensus report on Helicobacter pylori gastritis

    OpenAIRE

    Sugano, Kentaro; Tack, Jan; Kuipers, Ernst J.; David Y Graham; El-Omar, Emad M.; Miura, Soichiro; Haruma, Ken; Asaka, Masahiro; Uemura, Naomi; Malfertheiner, Peter

    2015-01-01

    Objective To present results of the Kyoto Global Consensus Meeting, which was convened to develop global consensus on (1) classification of chronic gastritis and duodenitis, (2) clinical distinction of dyspepsia caused by Helicobacter pylori from functional dyspepsia, (3) appropriate diagnostic assessment of gastritis and (4) when, whom and how to treat H. pylori gastritis. Design Twenty-three clinical questions addressing the above-mentioned four domains were drafted for which expert panels ...

  4. Gastric emptying in patients with fundal gastritis and gastric cancer.

    OpenAIRE

    Tatsuta, M.; Iishi, H.; Okuda, S

    1990-01-01

    Gastric emptying was compared in patients with gastric cancers and fundal gastritis to determine its value in identifying patients at high risk of gastric cancer. Gastric emptying was measured by the acetaminophen absorption method, and the extent of fundal gastritis was determined by the endoscopic Congo red test. The results showed that gastric emptying was significantly slower in patients with severe fundal gastritis than in those without. Gastric emptying in patients with differentiated a...

  5. Helicobacter Pylori Gastritis, a Presequeale to Coronary Plaque

    OpenAIRE

    Raut, Shrikant C.; Patil, Vinayak W; Dalvi, Shubhangi M; Bakhshi, Girish D.

    2015-01-01

    Helicobacter pylori are considered the most common human pathogen colonizing gastric mucosa. Gastritis with or without H. pylori infection is associated with increase in levels of homocysteine and high-sensitivity C-reactive protein (hs-CRP) but a more pronounced increase is noted in gastritis with H. pylori infection. Increasing level of homocysteine, due to decreased absorption of vitamin B12 and folic acid, together with increased CRP levels in gastritis with H. pylori infection may be the...

  6. Comparison of Helicobacter pylori infection and gastric mucosal histological features of gastric ulcer patients with chronic gastritis patients

    Institute of Scientific and Technical Information of China (English)

    Chuan Zhang; Nobutaka Yamada; Yun-Lin Wu; Min Wen; Takeshi Matsuhisa; Norio Matsukura

    2005-01-01

    AIM: To compare Helicobacter pyloriinfection and gastric mucosal histological features of gastric ulcer patients with chronic gastritis patients in different age groups and from different biopsy sites.METHODS: The biopsy specimens were taken from the antrum, corpus and upper angulus of gastric ulcer and chronic gastritis patients. Giemsa staining, improved Toluidine-blue staining and H pylori-specific antibody immune staining were performed as appropriate for the histological diagnosis of H pylori infection. Hematoxylineosin staining was used for the histological diagnosis of activity of H pylori infection, mucosal inflammation,glandular atrophy and intestinal metaplasia and scored into four grades according to the Updated Sydney System.RESULTS: Total rate of H pylori infection, mucosal inflammation, activity of H pylori infection, glandular atrophy and intestinal metaplasia in 3 839 gastric ulcer patients (78.5%, 97.4%, 82.1%, 61.1% and 64.2%,respectively) were significantly higher than those in 4 102chronic gastritis patients (55.0%, 90.3%, 56.2%, 36.8%,and 37.0%, respectively, P<0.05). The rate of H pylori colonization of chronic gastritis in <30 years, 31-40 years,41-50 years, 51-60 years, 61-70 years and >70 years age groups in antrum was 33.3%, 41.7%, 53.6%, 57.3%,50.7%, 43.5%, respectively; in corpus, it was 32.6%,41.9%, 53.8%, 60.2%, 58.0%, 54.8%, respectively; in angulus, it was 32.4%, 42.1%, 51.6%, 54.5%, 49.7%,43.5%, respectively. The rate of Hpyloricolonization of gastric ulcer in <30 years, 31-40 years, 41-50 years,51-60 years, 61-70 years and >70 years age groups in antrum was 60.5%, 79.9%, 80.9%, 66.8%, 59.6%, 45.6%,respectively; in corpus, it was 59.7%, 79.6%, 83.6%,80.1%, 70.6%, 59.1%, respectively; in angulus, it was61.3%, 77.8%, 75.3%, 68.8%, 59.7%, 45.8%,respectively. The rate of H pylori colonization at antrum was similar to corpus and angulus in patients, below50 years, with chronic gastritis and in patients, below40 years, with

  7. Cell proliferation in the gastric corpus in Helicobacter pylori associated gastritis and after gastric resection.

    OpenAIRE

    Lynch, D A; Mapstone, N P; Clarke, A. M.; Jackson, P.; Dixon, M F; Quirke, P; Axon, A T

    1995-01-01

    Patients who have undergone gastric resection are at higher risk of developing gastric carcinoma than normal subjects, and bile reflux is believed to play a role in carcinogenesis. An increase in mucosal cell proliferation increases the likelihood of a neoplastic clone of epithelial cells emerging, particularly where there is chronic epithelial injury associated with bile reflux. Helicobacter pylori is considered a major risk factor for gastric cancer in the intact stomach. It has been shown ...

  8. Translation and corpus design

    OpenAIRE

    Zanettin, Federico

    2011-01-01

    In this article I discuss the role of translated texts in different types of corpora. I first consider the role of translations in corpus-based monolingual linguistics, arguing that while translated texts are often excluded from corpora on the basis of a more or less implicit assumption that they “corrupt” the reference norm for a language, this assumption does not seem to be justified on theoretical grounds. For the same reason, translated texts should also be included in bi- and multi-lingu...

  9. The relationship between helicobacter pylori infection with chronic gastritis and peptic ulcer%幽门螺杆菌感染与慢性胃炎和消化性溃疡的关系

    Institute of Scientific and Technical Information of China (English)

    赵荣章

    2015-01-01

    目的:探讨幽门螺杆菌(Hp)感染与慢性胃炎、消化性溃疡的关系。方法:收治胃镜检查确诊的慢性胃炎、消化性溃疡患者151例,包括慢性浅表性胃炎、慢性糜烂性胃炎、慢性萎缩性胃炎、胆汁反流性胃炎以及胃和十二指肠溃疡,分别给予胃黏膜组织活检及快速尿素酶试验检查Hp感染情况,分析炎性反应情况与Hp感染的关系。结果:慢性萎缩性胃炎37例,Hp感染阳性率86.48%;慢性糜烂性胃炎36例,Hp感染阳性率80.56%;慢性浅表性胃炎26例,Hp感染阳性率65.38%;胆汁反流性胃炎22例,Hp感染阳性率36.36%,消化性溃疡30例,Hp感染阳性率80.00%。慢性萎缩性胃炎阳性率最高,胆汁反流性胃炎阳性率最低,差异具有统计学意义(P<0.05)。结论:几种常见的慢性胃炎、消化性溃疡均伴有不同程度Hp的感染,不同胃炎、消化性溃疡中Hp感染率差异具有统计学意义。慢性糜烂性胃炎、慢性萎缩性胃炎以及消化性溃疡感染Hp明显高于正常人群,从而提出Hp感染是产生的重要致病因素。%Objective:To investigate the relationship between helicobacter pylori(Hp) infection with chronic gastritis and peptic ulcer.Methods:151 patients with chronic gastritis or peptic ulcer were selected,including chronic superficial gastritis,chronic erosive gastritis,chronic atrophic gastritis,bile reflux gastritis,gastric and duodenal ulcer.All of those patients were treated with gastric mucosal biopsy and rapid urease test to detected helicobacter pylori infection,then we analyzed the relationship between inflammatory response and Hp infection.Results:37 cases were with chronic atrophic gastritis,and the positive rate of Hp infection was 86.48%;36 cases were chronic erosive gastritis,and the positive rate was 80.56%;26 cases were chronic superficial gastritis, and the positive rate was 65.38%;22 cases were bile reflux gastritis,and the positive rate

  10. Clinical pathology of primary bile reflux gastritis

    Directory of Open Access Journals (Sweden)

    Ping YAO

    2011-05-01

    Full Text Available Objective To analyze the clinical and pathological features of primary bile reflux gastritis(BRG.Methods Endoscopy,Helicobacter pylori(H.pylori detection,and histopathologic examination were performed in 218 patients with primary BRG(observed group and 236 patients with simple chronic gastritis(SCG,control group as identified by gastroscope in order to analyze the endoscopic abnormalities,the frequency of H.pylori infection,pathological features and scores of inflammation.Results The frequency of H.pylori infection was 39.0%(85/218 in the observed group,which was significantly lower than that in the control group [52.1%(123/236].The topographic abnormalities of the antral mucosa as detected by gastroscopy,i.e.,congestion,hemorrhagic spots,erosion were not significantly different between BRG and SCG patients(P > 0.05.The scores of chronic and active inflammation were higher in patients when H.pylori infection was present than in patients without H.pylori infection in both groups(P < 0.05.The scores of inflammation,the detection rates of the antral intestinal metaplasia,antral atrophy and atypical hyperplasia were all higher in observed group than in control group(P < 0.05.The incidence of lengthening of gastric pits,telangiectasis or interstitial edema in BRG patients was also significantly higher than those in SCG patients(P < 0.05.Conclusions Primary BRG shows features of chemical gastritis with a higher tendency toward mucosal atrophy,intestinal metaplasia and atypical hyperplasia.Gastropic examination and biopsy should be emphasized.

  11. Hemorrhagic gastritis caused by cow's milk protein allergy

    OpenAIRE

    SEVİNÇ, Eylem; ARSLAN, Duran; , Haluk AKAR

    2013-01-01

    Cow's milk protein allergy is frequently seen in infancy. Its findings can be diverse, including different histopathological involvement ranging from a superficial to hemorrhagic gastritis. Children presenting with resistant emesis, hematemesis and hemorrhagic gastritis should be investigated for cow's milk allergy. Endoscopy and biopsy are important in the diagnosis.

  12. Du corpus au dictionnaire

    CERN Document Server

    Jacquemin, Bernard

    2009-01-01

    In this article, we propose an automatic process to build multi-lingual lexico-semantic resources. The goal of these resources is to browse semantically textual information contained in texts of different languages. This method uses a mathematical model called Atlas s\\'emantiques in order to represent the different senses of each word. It uses the linguistic relations between words to create graphs that are projected into a semantic space. These projections constitute semantic maps that denote the sense trends of each given word. This model is fed with syntactic relations between words extracted from a corpus. Therefore, the lexico-semantic resource produced describes all the words and all their meanings observed in the corpus. The sense trends are expressed by syntactic contexts, typical for a given meaning. The link between each sense trend and the utterances used to build the sense trend are also stored in an index. Thus all the instances of a word in a particular sense are linked and can be browsed easily...

  13. Study on the pathological basis of classification of spleen deficiency in chronic gastritis

    Institute of Scientific and Technical Information of China (English)

    尹光耀; 张武宁; 沈小静; 何雪芬; 陈一

    2004-01-01

    Background Spleen in Traditional Chinese Medicine (TCM) is not actually the spleen in the anatomic sense designated in western medicine because its functions basically belong to the physiological category of digestive system in modern medicine, and it represents a macroscopic concept of digestion, absorption and nutrition metabolism. Spleen deficiency syndrome refers to the clinical phenomena such as hypofunction of digestion, absorption and nutrition metabolism. By integrating TCM with modern medicine , this paper is intended to explore the pathological basis of classification of spleen deficiency in chronic gastritis.Method By means of optical microscope, scanning electron microscope (SEM), transmission electron microscope (TEM) and histochemical staining, we conducted histopathological and subcellular ultrastructural (nuclei and mitochondrial) analysis of gastric mucosa of 188 patients of spleen deficiency, and that of 42 voluntary blood donors without clinical symptoms. Results The gastric mucosa of patients with spleen Qi deficiency (SQD) and spleen yang deficiency (SyangD) could either be affected by organic lesion (type G-occurring on the basis of chronic superficial gastritis (CSG), chronic atrophic gastritis (CAG)) or unaffected (type F-chiefly belonging to functional indigestion); spleen yin deficiency (SyinD) and spleen deficiency with Qi stagnation (SDQS) both occurred on the basis of CSG and CAG; and the degree of mucosa inflammatory cells infiltration, the degree of decrease in glands propria, and the incidence of IMⅡb in CSG and CAG were more serious than those of G-SQD and G-SyangD, P<0.05-0.01.Conclusion Spleen deficiency syndrome is likely to occur on the basis of organic lesion of gastric mucosa (disease with symptoms of both CSG or CAG and spleen deficiency symptoms), as well as on the basis of inorganic lesion of gastric mucosa (nondisease with symptoms, which is, despite spleen deficiency symptoms, there is no CSG or CAG). Besides, the

  14. Study on the pathophysiologic basis of classification of 'spleen' deficiency in chronic gastritis

    Institute of Scientific and Technical Information of China (English)

    YIN Guang-yao; CHEN Yi; SHEN Xiao-jing; HE Xue-fen; ZHANG Wu-ning

    2005-01-01

    Background Most of the studies on traditional Chinese medicine (TCM)‘spleen’deficiency syndrome in the recent 30 years were conducted only on the basis of single functional index, neglecting the study on the pathophysiologic internal relationship between spleen deficiency syndrome and gastric diseases in modern medicine. But it was at the subcellular molecular biological level that we explored the pathophysiologic basis of classification of spleen deficiency in chronic gastritis by detecting the bioactive substances in gastric mucosa nuclei and mitochondria. Methods By means of optical microscope, scanning electron microscope (SEM), transmission electron microscopy (TEM) and histochemical staining, we conducted histopathological, subcellular ultrastructural analysis and nuclei and mitochondrial ultrastructural analysis of gastric mucosa of 188 spleen deficiency patients and of 42 voluntary blood donors. At the same time, bioactive substances were measured by means of X-ray energy dispersive analysis system (EDAX) image analysis system, radioimmunoassay method and chemiluminescence method. Results The content of cAMP, superoxide dismutase (SOD), Zn and Cu in gastric mucosa, and the content of Zn and Cu in mitochondria decreased progressively in order of groups: healthy control (HC), spleen Qi deficiency without organic lesion (F-SQD), spleen Yang deficiency without organic lesion (F-SyangD), disease without symptoms group, spleen Qi deficiency with organic lesion (G-SQD), spleen Yang deficiency with organic lesion (G-SyangD), spleen Yin deficiency (SyinD) and spleen deficiency with Qi stagnation (SDQS), chronic spleen deficiency gastritis (CSG) and chronic atrophic gastritis (CAG); decreased in order of HC, intestinal metaplasia (IM)Ⅰa, IMⅠb, IMⅡa and IMⅡb, P<0.05. The content of DNA, Zn and Cu in nuclei progressively increased in order mentioned above, P<0.05.Conclusions The quantitative changes of gastric mucosal cAMP, SOD, Zn, Cu, of mitochondrial Zn

  15. The radiological study of areas gastricae in chronic gastritis

    International Nuclear Information System (INIS)

    A chronic gastritis is common and clinically significant, but specific findings were rarely described in UGIS. And the authors attempted to clarify the area gastrica of the stomach related to the chronic gastritis. The authors reviewed 'Areae gastricae' micromucosal patterns of stomach, retrospectively with double contrast barium meal study in 16 cases, histologically proven cases of chronic gastritis by endoscopic biopsy from January 1, 1980 to June 30, 1980. Here the commonest site of chronic gastritis is evident in 12 cases in pyloric gland area, and a sixe of area gastrica shows above 2.5mm in longest diameter with combinding morphology, regular to irregular, 3 to 1 and coarse barium accumulations of intervening sulci. The chronic gastritis could be suggested with this better technique of UGIS

  16. Atrophic Acne Scarring: A Review of Treatment Options

    OpenAIRE

    Hession, Meghan T.; Graber, Emmy M.

    2015-01-01

    Background: Scarring is an unfortunate and frequent complication of acne, resulting in significant psychological distress for patients. Fortunately, numerous treatment options exist for acne scarring. Objectives: To extensively review the literature on treatment options for atrophic acne scarring. Materials and methods: A comprehensive literature search was conducted on the following topics: dermabrasion, subcision, punch techniques, chemical peels, tissue augmentation, and lasers. Results: T...

  17. X-ray diagnosis of erosive gastritis

    International Nuclear Information System (INIS)

    A series of 602 patients are studied according to a standard protocol including double contrast examination, taking films with dosed compression and complete filling (accordingly 3+3+1 radiographs). A barium suspension at concentration 200.0 BaSO4 in 100 ml water is used as a positive contrast medium, and effervescent powder or pills - as a negative contrast. Erosive gastritis is diagnosed in 48 patients (7.9%) of which 38 present complete erosions (79.2%), 6 (12.6%) - incomplete, and 4 (8.3%) - mixed erosions. In 35 cases (72.9%) erosions are differentiated in double-contrast films, while in 21 (43.8%) - in those with compression. The advantage of the double contrast technique consists in visualization of erosions of the body of the stomach and discovering of incomplete erosions. In 483 patients a comparative assessment is done of the X-ray and endoscopic findings. There are recorded 5 false-positive and 25 false-negative radiological results. The sensitivity of the X-ray study in terms of erosive gastritis amounts to 59.7%. 15 refs., 4 figs. (orig.)

  18. [Corpus Hermeticum in history].

    Science.gov (United States)

    Bugaj, R

    2001-01-01

    The originator and founder of hermetism was the mythical Hermes Trismegistos, a deity of the syncretic Hellenistic religion that came into being through the identification of the Greek god Hermes with the Egyptian god Thot. In later Hellenistsic times various hermetic writers considered Hermes Trismegistos to have been a historical personage, a king, prophet and philosopher (physician), as well as author of many widely disseminated writings that made up the so-called Corpus Hermeticum (eighteen separate treatises from the 2nd-4th centuries AD) and the so-called Emerald Table (Tabula Smaragdina). The Corpus Hermeticum is a collection of treatises of a philosophical, religious, theological as well as theosophical nature. The collection played an important role in the development of the philosophy of alchemy and hermetism, and formed the basis for an alchemist philosophy of nature. There are currently two views among scholars on the origins of hermetism. According to one, hermetism derived directly from Egypt, while according to the other it orginated in Greece. In the years 1945-46 a number of hermetic texts forming part of the now famous gnostic "library" were discovered in Nag-Hammadi (Chenosboskion) in Upper Egypt. The Coptic texts from Nag-Hammadi date from the middle of the 4th century AD, and according to experts are translations from the Greek. Some authors (R. Reitzenstein and T. Zieliński) have suggested that along with the appearance in Egypt of the Hermetic Books, attributed to Hermes Trismegistos, there also appeared a new god in Egypt, Poimandres, and a new religion was established, hermetism, which competed for influence with Christianity. The present article discusses the main of the hermetic treatises, including Poimandres, which contains an account of the creation of the world. The article also discusses the reasons for the decline of hermetism as a religion and stresses that in spite of this decline the doctrine managed to survive in the form of

  19. Corpus vitreum, retina og chorioidea biopsi

    DEFF Research Database (Denmark)

    Scherfig, Erik Christian Høegh

    2002-01-01

    oftalmology, biopsy, choroid, corpus vitreum, retina, malignant melanoma, biopsy technic, retinoblastoma......oftalmology, biopsy, choroid, corpus vitreum, retina, malignant melanoma, biopsy technic, retinoblastoma...

  20. Review on Clinical and Mechanism Studies of Moxibustion Therapy for Chronic Gastritis

    Institute of Scientific and Technical Information of China (English)

    Zhu Hui-wen; Ruan Chun-xun; Cao Shu-fei; Wu Huan-gan; Li Jing

    2014-01-01

    By computer research, the literature of clinical and experimental studies on moxibustion therapy for chronic gastritis in the recent fifteen years was collected, sorted and analyzed, in order to understand the general situation about the clinical and experimental studies on moxibustion therapy for chronic gastritis, summarize the regularity of moxibustion therapy for chronic gastritis, so as to guide the treatment of chronic gastritis.

  1. Isolated complete corpus callosal agenesis

    Directory of Open Access Journals (Sweden)

    Jaiganesh S, Venkateshwaran A, Naresh Kumar C, Rajasekhar KV

    2014-11-01

    Full Text Available Isolated complete corpus callosal agenesis is a rare entity. Usually this condition will be an associated finding in other syndromes. 3 month old male child came with complaints of deformed foot on both sides, not having a social smile and neck holding. Patient referred to the Radiology department for MRI brain which showed complete absence of corpus callosum, widely separated and parallely placed lateral ventricles, colpocephaly, high riding of 3rd ventricle and absence of cingulate gyrus and radial arrangement of gyri along the interhemispheric fissure. Hence it was reported as isolated complete corpus callosal agenesis and this article describes the Embryogenesis, anatomy, developmental anomalies and its clinical manifestations & prognosis.

  2. Helicobacter pylori lipopolysaccharide:Biological activities in vitro and in vivo, pathological correlation to human chronic gastritis and peptic ulcer

    Institute of Scientific and Technical Information of China (English)

    Yi-Hui Luo; Jie Yan; Ya-Fei Mao

    2004-01-01

    that of the patients with atrophic gastritis (3/10, 30.0%)(X2=7.50-9.66, P<0.01).CONCLUSION: The biological activities of H-LPS were weaker than those of E-LPS, the activities of H-LPS of lowering rabbit blood pressure and inducing rabbit PBMC were relatively stronger. H-LPS may play a critical role in inducing inflammatory reaction in human gastritis.

  3. Gastritis Cystica Polyposa with Gastroduodenal Intussuception: A Case Report

    International Nuclear Information System (INIS)

    Gastritis cystica polyposa is an uncommon benign lesion that normally occurs on the gastric side of a gastroenterostomy site but is rarely found in patients without a prior history of stomach surgery. We report a case of a 41-year-old woman with gastrodeuodenal intussusception due to gastritis cystica polyposa that developed in an unoperated stomach. CT revealed gastroduodenal intussusception and a cystic and solid mass with fat density in the second portion of the duodenum. Surgery and a pathologic examination confirmed gastritis cystica polyposa.

  4. Gastritis Cystica Polyposa with Gastroduodenal Intussuception: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Kwak, Soon Hyuk; Bae, Il Hun; Park, Kil Sun; Lee, Seung Young; Jeon, Min Hee; Cho, Bum Sang; Kamg, Min Ho [Dept. of Radilogy, College of Medicine and Medical Research Institute, Chonbuk National University, Chonju (Korea, Republic of); Ryu, Dong Hee [Dept. of Surergy, College of Medicine and Medical Research Institute, Chonbuk National University, Chonju (Korea, Republic of); Lee, Ho Chang [Dept. of Pathology, College of Medicine and Medical Research Institute, Chonbuk National University, Chonju (Korea, Republic of)

    2011-04-15

    Gastritis cystica polyposa is an uncommon benign lesion that normally occurs on the gastric side of a gastroenterostomy site but is rarely found in patients without a prior history of stomach surgery. We report a case of a 41-year-old woman with gastrodeuodenal intussusception due to gastritis cystica polyposa that developed in an unoperated stomach. CT revealed gastroduodenal intussusception and a cystic and solid mass with fat density in the second portion of the duodenum. Surgery and a pathologic examination confirmed gastritis cystica polyposa.

  5. Epithelial cell proliferation and glandular atrophy in lymphocytic gastritis: Effect of H pylori treatment

    OpenAIRE

    Mäkinen, Johanna M; Niemelä, Seppo; Kerola, Tuomo; Lehtola, Juhani; Karttunen, Tuomo J

    2003-01-01

    AIM: Lymphocytic gastritis is commonly associated with Helicobacter pylori infection. The presence of glandular atrophy and foveolar hyperplasia in lymphocytic gastritis suggests abnormalities in cell proliferation and differentiation, forming a potential link with the suspected association with gastric cancer. Our aim was to compare epithelial proliferation and morphology in H pylori associated lymphocytic gastritis and H pylori gastritis without features of lymphocytic gastritis, and to eva...

  6. Gastritis and Gastric Ulcers in Working Dogs

    Science.gov (United States)

    Davis, Michael S.; Williamson, Katherine K.

    2016-01-01

    Gastritis and gastric ulcers are an important cause of morbidity and mortality in canine athletes. Although the majority of scientific work on this condition has been performed in ultraendurance racing sled dogs, this condition has been identified in other canine athletes, including sled dogs competing in shorter events and dogs performing off-leash explosive detection duties. The cause of the syndrome is unknown, but current hypotheses propose a link between exercise-induced hyperthermia and loss of gastric mucosal barrier function as an early event in the pathogenesis. Treatment is focused on prevention of clinical disease using acid secretion inhibitors, such as omeprazole, which has excellent efficacy in controlled clinical studies. PMID:27092307

  7. Multimodal Management of Atrophic Acne Scarring in the Aging Face

    OpenAIRE

    Gerald O’Daniel, T.

    2011-01-01

    Atrophic facial acne scarring is a widely prevalent condition that can have a negative impact on a patient’s quality of life. The appearance of these scars is often worsened by the normal effects of aging. A number of options are available for the treatment of acne scarring, including chemical peeling, dermabrasion, ablative or nonablative laser resurfacing, dermal fillers, and surgical techniques such as subcision or punch excision. Depending on the type and extent of scarring, a multimodal ...

  8. Malignant atrophic papulosis (Köhlmeier-Degos disease) - A review

    OpenAIRE

    Theodoridis Athanasios; Makrantonaki Evgenia; Zouboulis Christos C

    2013-01-01

    Abstract Definition of the disease Malignant atrophic papulosis (MAP), described independently by Köhlmeier and Degos et al., is a rare, chronic, thrombo-obliterative vasculopathy characterized by papular skin lesions with central porcelain-white atrophy and surrounding teleangiectatic rim. Epidemiology Less than 200 cases have been described in the literature. The first manifestation of MAP usually occurs between the 20th and 50th year of life. Clinical description The cutaneous clinical pic...

  9. Railroading technique of dermal grafting for linear atrophic scarring

    Directory of Open Access Journals (Sweden)

    Balakrishnan Nirmal

    2014-01-01

    Full Text Available Dermal grafting is a valuable technique in the field of dermatosurgery for the treatment of atrophic scars where the source of filler material is the patient′s own dermis. However, it is underused for the reasons being difficulties in placing the graft in the tunnel, keratin cysts and complications due to biofilms. Railroading technique used in urology for rupture urethra has been described for dermal grafts to overcome the technical difficulties of graft placement.

  10. Microneedling therapy in atrophic facial scars: An objective assessment

    Directory of Open Access Journals (Sweden)

    Majid Imran

    2009-01-01

    Full Text Available Background: Atrophic facial scars are always a challenge to treat, especially the ones that are deep-seated and/or involve much of the face. Microneedling or dermaroller therapy is a new addition to the treatment armamentarium for such scars that offers a simple and reportedly effective management of these scars. Aims: The aim of the present study was to perform an objective evaluation of the efficacy of dermaroller treatment in atrophic facial scars of varying etiology. Materials and Methods: Thirty-seven patients of atrophic facial scarring were offered multiple sittings of microneedling (dermaroller treatment and their scars were evaluated and graded clinically and by serial photography at the start as well as at two months after the conclusion of the treatment protocol. Any change in the grading of scars after the end of treatment and follow-up period was noted down. The patients were also asked to evaluate the effectiveness of the treatment received on a 1-10 point scale. The efficacy of dermaroller treatment was thus assessed both subjectively by the patients as well as objectively by a single observer. Results: Overall 36 out of the total of 37 patients completed the treatment schedule and were evaluated for its efficacy. Out of these 36 patients, 34 achieved a reduction in the severity of their scarring by one or two grades. More than 80% of patients assessed their treatment as ′excellent′ on a 10-point scale. No significant adverse effects were noted in any patient. Conclusions: Microneedling therapy seems to be a simple and effective treatment option for the management of atrophic facial scars.

  11. Microneedling Therapy for Atrophic Acne Scars: An Objective Evaluation

    OpenAIRE

    El-Domyati, Moetaz; Barakat, Manal; Awad, Sherif; Medhat, Walid; El-Fakahany, Hasan; Farag, Hanna

    2015-01-01

    Objective: Treatment of acne scarring is always a challenge. Microneedling therapy or percutaneous collagen induction is a new addition to the treatment modalities for such scars and has been reported to be simple and effective in atrophic acne scar treatment. The aim of this study is to evaluate the clinical effect and objectively quantify the histological changes of acne scarring in response to skin microneedling. Design: A prospective clinical study. Participants: Ten patients with differe...

  12. Helicobacter pylori infection, glandular atrophy and intestinal metaplasia in superficial gastritis, gastric erosion, erosive gastritis, gastric ulcer and early gastric cancer

    OpenAIRE

    Zhang, Chuan; Yamada, Nobutaka; Wu, Yun-Lin; Wen, Min; Matsuhisa, Takeshi; Matsukura, Norio

    2005-01-01

    AIM: To evaluate the histological features of gastric mucosa, including Helicobacter pylori infection in patients with early gastric cancer and endoscopically found superficial gastritis, gastric erosion, erosive gastritis, gastric ulcer.

  13. Fuentes de variabilidad en el diagnóstico de gastritis atrófica multifocal asociada con la infección por Helicobacter pylori

    Directory of Open Access Journals (Sweden)

    Luis Eduardo Bravo

    2009-11-01

    Full Text Available Introduction: Multiple sampling from different sites of the stomach as well as the number of fragments of gastric mucosa available for histopathologic evaluation are important sources of variation when classifying and grading chronic gastritis. Objective: To estimate the sensitivity of the number of fragments of gastric mucosa necessary to establish the diagnosis of atrophic gastritis with intestinal metaplasia, gastric dysplasia and H. pylori infection. In addition, this study will attempt to assess the intra-observer variability in the classification of these premalignant gastric lesions. Methods: This is a 6 year-cohort study, wherein 1958 gastric endoscopic procedures performed by two gastroenterologists were reviewed. Five gastric biopsy samples were obtained from the antrum, body and lesser curvature during each procedure. One pathologist was in charge of reviewing the five histopathology samples for each subject and providing a definitive diagnosis which was used as the gold standard. Each gastric mucosa sample reviewed led to an individual diagnosis for that sample which was compared with the gold standard. Intra-observer variability was assessed in 127 individuals who correspond to a random sample of 20% of the total endoscopic procedures performed during the 72 month-follow-up. Results: The sensitivity of the diagnosis of intestinal metaplasia (IM and gastric dysplasia increased proportionally with the number of gastric mucosa samples reviewed. The lesser curvature of the stomach had the highest sensitivity for the diagnosis of IM and dysplasia, among all the stomach regions studied. Just one sample of gastric mucosa attained a sensitivity of 95.9% for the detection of H. pylori infection. The intra-observer agreement for the diagnosis of multifocal atrophic gastritis was 86.1% and the kappa value was 0.79 (95% CI 0.76-0.85. Alcohol-fixed biopsy specimens were inadequate to diagnose H. pylori infection and to assess dysplasia

  14. The ATIS sign language corpus

    OpenAIRE

    Bungeroth, Jan; Stein, Daniel; Dreuw, Philippe; Ney, Hermann; Morrissey, Sara; Way, Andy; van Zijl, Lynette

    2008-01-01

    Systems that automatically process sign language rely on appropriate data. We therefore present the ATIS sign language corpus that is based on the domain of air travel information. It is available for five languages, English, German, Irish sign language, German sign language and South African sign language. The corpus can be used for different tasks like automatic statistical translation and automatic sign language recognition and it allows the specific modelling of spatial references in sign...

  15. Combination therapy in the management of atrophic acne scars

    Directory of Open Access Journals (Sweden)

    Shilpa Garg

    2014-01-01

    Full Text Available Background: Atrophic acne scars are difficult to treat. The demand for less invasive but highly effective treatment for scars is growing. Objective: To assess the efficacy of combination therapy using subcision, microneedling and 15% trichloroacetic acid (TCA peel in the management of atrophic scars. Materials and Methods: Fifty patients with atrophic acne scars were graded using Goodman and Baron Qualitative grading. After subcision, dermaroller and 15% TCA peel were performed alternatively at 2-weeks interval for a total of 6 sessions of each. Grading of acne scar photographs was done pretreatment and 1 month after last procedure. Patients own evaluation of improvement was assessed. Results: Out of 16 patients with Grade 4 scars, 10 (62.5% patients improved to Grade 2 and 6 (37.5% patients improved to Grade 3 scars. Out of 22 patients with Grade 3 scars, 5 (22.7% patients were left with no scars, 2 (9.1% patients improved to Grade 1and 15 (68.2% patients improved to Grade 2. All 11 (100% patients with Grade 2 scars were left with no scars. There was high level of patient satisfaction. Conclusion: This combination has shown good results in treating not only Grade 2 but also severe Grade 4 and 3 scars.

  16. Gut Feelings About Gastritis: When Your Stomach's Sick

    Science.gov (United States)

    ... disclaimer . Subscribe Gut Feelings About Gastritis When Your Stomach’s Sick Your stomach lining has an important job. It makes acid ... pain or an uncomfortable feeling in their upper stomach. But many other conditions can cause these symptoms. ...

  17. Indium-111 WBC detection of emphysematous gastritis in pancreatitis

    International Nuclear Information System (INIS)

    We present a case of emphysematous gastritis initially detected with 111In oxine-labeled white blood cell scintigraphy and subsequently confirmed by computed tomography. Early aggressive antibiotic and supportive therapy resulted in a successful clinical outcome

  18. Lymphocytic gastritis and Helicobacter pylori infection in gastric lymphoma.

    OpenAIRE

    Miettinen, A.; Karttunen, T J; Alavaikko, M.

    1995-01-01

    Lymphocytic gastritis and primary gastric lymphoma are rare conditions with unknown aetiology. It has recently been suggested that Helicobacter pylori has a role in the pathogenesis of both of them. The occurrence of lymphocytic gastritis and H pylori was studied in a series of patients with primary gastric lymphoma. The cases of primary gastric lymphomas (n = 35) diagnosed in years 1970-1993 were identified. The specimens of 22 cases contained gastric mucosa sufficiently so that the number o...

  19. Effect of Ursodeoxycolicacid in Treatment of Bile Gastritis

    Directory of Open Access Journals (Sweden)

    S. Kazem Nezam

    2012-06-01

    Full Text Available Background: Bile gastritis (gastropathy is a kind of gastritis which is caused by reflux of bile contents through duodenum on stomach. It can occur spontaneously without any former gastric surgeries which affect sphincter of pylorus. The positive impact of some certain drugs such as prokinetic agents e.g. metoclopramide, Proton-pump inhibitors (PPIs, cholestyramine and sucralfate in treating bile gastritis has been confirmed. This study has been conducted in order to analyze the effect of ursodeoxycholic acid (UDCA, which is a harmless drug, on patients with the bile gastritis. Materials and Methods: In this clinical trial, all patients with dyspepsia who were qualified to undertake endoscopy were enrolled and then 60 patients with bile gastritis were selected for the study. The patients were divided into two groups; a group was treated by UDCA, omeprazole and sucralfate and another one was treated with placebo, omeprazole and sucralfate for two weeks. Finally, at the end of the third week of treatment patients were examined.Results: A total of sixty 19-70 year-old patients (Mean: 46 years old included in this study. At the end of the study, there was not found any meaningful difference between the two groups in terms of pain intensity, heartburn intensity, severity of bloating, vomiting and early satiety; however, each group independently showed improvement of the mentioned indices after termination of the treatment (p=0.0005.Conclusion: Adding UDCA to the standard treatment (sucralfate is not clinically effective in curing the bile gastritis.

  20. Chronic gastritis rat model and role of inducing factors

    Institute of Scientific and Technical Information of China (English)

    Zun Xiang; Jian-Min Si; Huai-De Huang

    2004-01-01

    AIM: To establish an experimental animal model of chronic gastritis in a short term and to investigate the effects of several potential inflammation-inducing factors on rat gastric mucosa.METHODS: Twenty-four healthy, male SD rats were treated with intragastric administration of 600 mL/L alcohol, 20mmol/L sodium deoxycholate and 0.5 g/L ammonia (factor A), forage containing low levels of vitamins (factor B), and/or indomethacin (factor C), according to an L8(27)orthogonal design. After 12 wk, gastric antral and body mucosae were pathologically examined.RESULTS: Chronic gastritis model was successfully induced in rats treated with factor A for 12 wk. After the treatment of animals, the gastric mucosal inflammation was significantly different from that in controls, and the number of pyloric glands at antrum and parietal cells at body were obviously reduced (P<0.01). Indomethacin induced gastritis but without atrophy, and short-term vitamin deficiency failed to induce chronic gastritis and gastric atrophy, In addition,indomethacin and vitamin deficiency had no synergistic effect in inducing gastritis with the factor A. No atypical hyperplasia and intestinal metaplasia in the gastric antrum and body were observed in all rats studied.CONCLUSION: Combined intragastric administration of 600 mL/L alcohol, 20 mmol/L sodium deoxycholate and 0.5 g/L ammonia induces chronic gastritis and gastric atrophy in rats. Indomethacin induces chronic gastritis only.The long-term roles of these factors in gastric inflammation and carcinogenesis need to be further elucidated.

  1. Helicobacter pylori gastritis, a presequeale to coronary plaque

    Directory of Open Access Journals (Sweden)

    Shrikant C. Raut

    2015-03-01

    Full Text Available Helicobacter pylori are considered the most common human pathogen colonizing gastric mucosa. Gastritis with or without H. pylori infection is associated with increase in levels of homocysteine and high-sensitivity C-reactive protein (hs-CRP but a more pronounced increase is noted in gastritis with H. pylori infection. Increasing level of homocysteine, due to decreased absorption of vitamin B12 and folic acid, together with increased CRP levels in gastritis with H. pylori infection may be the earliest event in the process of atherosclerosis and plaque formation. Retrospective study conducted at tertiary care hospital in Mumbai by Department of Biochemistry in association with Department of Surgery. Eighty patients who underwent gastroscopy in view of gastritis were subjected to rapid urease test for diagnosis of H. pylori infection. Vitamin B12, folic acid, homocysteine and hs-CRP were analyzed using chemiluminescence immuno assay. Student’s t-test, Pearson’s correlation and linear regression used for statistical analysis. Patients with H. pylori gastritis had significantly lower levels of vitamin B12 (271.6±101.3 vs 390.6±176.7 pg/mL; P=0.0005, as well as higher levels of homocysteine (17.4±7.4 vs 13.8±7.8 mmol/L; P=0.037 and hs-CRP (2.5±2.9 vs 1.2±1.1 mg/L; P=0.017, than in patients without H. pylori gastritis. However, folic acid showed (8.9±3.2 vs 10.0±3.6 ng/mL; P=0.171 no significant difference. Elevated homocysteine and hs-CRP in H. pylori gastritis may independently induce endothelial dysfunction, leading to cardiovascular pathology.

  2. DEVELOPING SOFTWARE FOR CORPUS RESEARCH

    Directory of Open Access Journals (Sweden)

    Oliver Mason

    2008-06-01

    Full Text Available Despite the central role of the computer in corpus research, programming is generally not seen as a core skill within corpus linguistics. As a consequence, limitations in software for text and corpus analysis slow down the progress of research while analysts often have to rely on third party software or even manual data analysis if no suitable software is available. Apart from software itself, data formats are also of great importance for text processing. But again, many practitioners are not very aware of the options available to them, and thus idiosyncratic text formats often make sharing of resources difficult if not impossible. This article discusses some issues relating to both data and processing which should aid researchers to become more aware of the choices available to them when it comes to using computers in linguistic research. It also describes an easy way towards automating some common text processing tasks that can easily be acquired without knowledge of actual computer programming.

  3. Detection of gastritis by single- and double-contrast radiography

    International Nuclear Information System (INIS)

    Sixty-eight patients with various types of gastritis, 23 patients with normal stomachs, and four patients with other gastric diseases were examined in a prospective study to assess the sensitivity and specificity of single-contrast (SC) and double-contrast (DC) upper gastrointestinal examinations in the evaluation of gastritis. All patients underwent endoscopy with biopsy followed first by DC and then by SC radiography. The respective sensitivities of SC and DC radiography were 58% and 72% for all examinations and 59% and 77% for adequate examinations only. The respective specificities were 59% and 55% based on all examinations. Useful radiographic features included polypoid defects and erosions detected by both methods, abnormal folds and flattened margins detected by the SC technique, and narrowed lumen and crenulated margins detected by the DC technique. In 93% of all cases, the correct diagnosis was based on two or more of these radiographic features. According to this study, the radiographic sensitivity in the detection of gastritis is reliable only in cases of moderate-to-severe disease and only when based on findings of the DC examination. Neither SC nor DC radiography should be used as the primary screening method for patients with suspected gastritis, and the radiographic diagnosis should be restricted to the terms ''erosive'' or ''nonerosive gastritis.''

  4. The Lancaster Corpus of Mandarin Chinese.

    OpenAIRE

    McEnery, A. M.; Xiao, R. Z.

    2003-01-01

    The Lancaster Corpus of Mandarin Chinese (LCMC) addresses an increasing need within the research community for a publicly available balanced corpus of Mandarin Chinese. LCMC has been constructed as part of a research project undertaken by the Linguistics Department, Lancaster University. The corpus is designed as a Chinese match of the Freiburg-LOB Corpus of British English (FLOB), and, as such, will provide a valuable resource for contrastive studies between English and Chinese as well as a ...

  5. Paradigm Shift in the Management of the Atrophic Posterior Maxilla

    Directory of Open Access Journals (Sweden)

    Rabah Nedir

    2014-01-01

    Full Text Available When the posterior maxilla is atrophic, the reference standard of care would be to perform sinus augmentation with an autologous bone graft through the lateral approach and delayed implant placement. However, placement of short implants with the osteotome sinus floor elevation technique and without graft can be proposed for an efficient treatment of clinical cases with a maxillary residual bone height of 4 to 8 mm. The use of grafting material is recommended only when the residual bone height is ≤4 mm. Indications of the lateral sinus floor elevation are limited to cases with a residual bone height ≤ 2 mm and fused corticals, uncompleted healing of the edentulous site, and absence of flat cortical bone crest or when the patient wishes to wear a removable prosthesis during the healing period. The presented case report illustrates osteotome sinus floor elevation with and without grafting and simultaneous implant placement in extreme conditions: atrophic maxilla, short implant placement, reduced healing time, and single crown rehabilitation. After 6 years, all placed implants were functional with an endosinus bone gain.

  6. The Corpus of Czech Verse

    Czech Academy of Sciences Publication Activity Database

    Plecháč, Petr; Kolár, Robert

    2015-01-01

    Roč. 2, č. 1 (2015), s. 107-118. ISSN 2346-6901 R&D Projects: GA ČR GAP406/11/1825 Institutional support: RVO:68378068 Keywords : Czech poetry * versification * corpus linguistics * theory of verse Subject RIV: AJ - Letters, Mass-media, Audiovision

  7. Irregular Meal Timing Is Associated with Helicobacter pylori Infection and Gastritis

    OpenAIRE

    Lim, Su-Lin; Canavarro, Claudia; Zaw, Min-Htet; Zhu, Feng; Loke, Wai-Chiong; Chan, Yiong-Huak; Yeoh, Khay-Guan

    2013-01-01

    Helicobacter pylori (HP) is associated with chronic gastritis and gastric cancer, and more than half of the world's population is chronically infected. The aim of this retrospective study was to investigate whether an irregular meal pattern is associated with increased risk of gastritis and HP infection. The study involved 323 subjects, divided into three groups as follows: subjects with HP infection and gastritis, subjects with gastritis, and a control group. Subjects were interviewed on eat...

  8. Subclass distribution of mucosal IgG-producing cells in gastritis.

    OpenAIRE

    Valnes, K; Brandtzaeg, P

    1989-01-01

    IgG-mediated immune reactions are probably involved in the maintenance of gastritis and glandular atrophy; the mucosal IgG-subclass pattern may therefore influence the effect of local hypersensitivity mechanisms. In this study the proportions of IgG1-, IgG2-, IgG3-, and IgG4-producing immunocytes were determined by paired immunofluorescence staining in specimens from simple gastritis, gastritis after Billroth II (BII) resection, and gastritis associated with dermatitis herpetiformis (DH). The...

  9. Transient protein losing enteropathy associated with acute gastritis and campylobacter pylori.

    OpenAIRE

    Hill, I. D.; Sinclair-Smith, C; Lastovica, A J; Bowie, M D; Emms, M

    1987-01-01

    Three children presented with acute protein losing enteropathy and were found to have acute gastritis associated with Campylobacter pylori infection. Recovery from protein losing enteropathy was accompanied by resolution of the gastritis and the disappearance of C pylori from the gastric mucosa. Their clinical course suggested that the C pylori had caused the gastritis and the protein losing enteropathy. The association between gastritis caused by C pylori and protein losing enteropathy in ch...

  10. Features of gastritis predisposing to gastric adenoma and early gastric cancer

    OpenAIRE

    Meining, A.; Riedl, B; Stolte, M

    2002-01-01

    Background/Aims: Helicobacter pylori gastritis is a risk factor for the development of gastric cancer. The results of several studies indicate that gastric adenomas, which are considered premalignant lesions, may also be associated with H pylori gastritis. However, it is not clear whether there are different patterns of gastritis in these patients compared with patients with gastric cancer or patients with H pylori gastritis alone. Therefore, this study was designed to investigate the pattern...

  11. Campylobacter gastritis simulating Menetrier's disease by upper gastrointestinal radiography

    International Nuclear Information System (INIS)

    Within this decade it has been determined that primary gastritis in both children and adults is frequently associated with infection of the gastric mucosa with Campylobacter pylori. It is characterized by a chronic inflammatory process in which the mucosa of the gastric antrum is typically most severely involved. Other regions of the stomach may be involved and associated peptic ulcers of the stomach and duodenal bulb are frequent. A case of C. pylori gastritis is reported in which involvement of the gastric fundus and body produced severe rugal hypertrophy that resembled Menetrier's disease. (orig.)

  12. A fatal case of malignant atrophic papulosis (Degos' disease) in a man with factor V Leinden mutation and lupus anticoagulant

    DEFF Research Database (Denmark)

    Hohwy, Thomas; Jensen, Martin Glümer; Tøttrup, Anders; Steiniche, Torben; Fogh, Karsten

    2006-01-01

    Malignant atrophic papulosis (Degos' disease) is a very rare condition characterized by atrophic papular skin lesions and variable association of systemic involvement. We describe a 33-year-old man who presented with a widespread skin eruption consistent with malignant atrophic papulosis. During...

  13. Magnetoterapia en pacientes con gastritis crónica antral Magnetotherapy in patients with chronic antral gastritis

    OpenAIRE

    Marvelis Domínguez Iglesias; Zoila Pérez Rodríguez

    2012-01-01

    Introducción: la gastritis crónica es una de las 40 enfermedades más frecuentes en Cuba, su etiología es multifactorial y el Helicobacter pylori es el agente causal principal. A los campos magnéticos se le reconocen los efectos antiinflamatorios, analgésico, regenerador de tejidos e inhibidor del desarrollo de gérmenes patógenos. Objetivo: evaluar la utilidad de la magnetoterapia en pacientes con gastritis crónica antral. Métodos: se realizó un estudio cuasi-experimental prospectivo en 30 pac...

  14. Chemical gastritis and Helicobacter pylori related gastritis in patients receiving non-steroidal anti-inflammatory drugs: comparison and correlation with peptic ulceration.

    OpenAIRE

    Taha, A S; Nakshabendi, I.; Lee, F D; Sturrock, R D; Russell, R I

    1992-01-01

    AIMS: To evaluate the prevalence and significance of chemical gastritis, in comparison with gastritis related to Helicobacter pylori in patients receiving non-steroidal anti inflammatory drugs (NSAIDs). METHODS: Two hundred and eighteen patients were studied, 174 of whom were taking NSAIDs. Chemical gastritis was defined as the presence of foveolar hyperplasia, muscle fibres in the lamina propria, oedema and vasodilation, in the absence of a chronic inflammatory cell infiltrate. RESULTS: Chem...

  15. Cerebral atrophic and degenerative changes following various cerebral diseases, (1)

    International Nuclear Information System (INIS)

    Patients having cerebral atrophic and degenerative changes following hypoglycemia, cerebral contusion, or cerebral hypoxia including cerebrovascular disorders were reported. Description was made as to cerebral changes visualized on CT images and clinical courses of a patient who revived 10 minutes after heart stoppage during neurosurgery, a newborn with asphyxia, a patient with hypoglycemia, a patient who suffered from asphyxia by an accident 10 years before, a patient with carbon monoxide poisoning at an acute stage, a patient who had carbon monoxide poisoning 10 years before, a patient with diffuse cerebral ischemic changes, a patient with cerebral edema around metastatic tumor, a patient with respiration brain, a patient with neurological sequelae after cerebral contusion, a patient who had an operation to excise right parietal lobe artery malformation, and a patient who was shooted by a machine gun and had a lead in the brain for 34 years. (Tsunoda, M.)

  16. Nuclear factor kappa-B and histopathology of chronic gastritis

    Directory of Open Access Journals (Sweden)

    Moorchung Nikhil

    2010-07-01

    Full Text Available Background: Studies suggest that nuclear factor kappa-B (NFκB activation may be a critical event in the production of proinflammatory molecules in Helicobacter pylori-associated gastritis. Materials and Methods: This study examines the expression and activity of NFκB in situ in antral biopsies of 42 consecutive patients with immunohistochemical techniques. Results: NFκB was highly expressed in the gastric epithelial cells. The number of cells showing activated NFκB correlated with the activity of gastritis (P < 0.05, a measure of neutrophil influx, whereas no correlation was found with the chronicity of inflammation, a measure of the presence of mononuclear inflammatory cells. There was also a strong inverse association with the presence and grade of atrophy. Conclusion: This correlation is direct evidence of the importance of NFκB dependent signal transduction for neutrophil influx in gastritis. The role of NFκB appears to be only in the initial stages of gastritis, there is no role for the molecule in the development of chronic inflammation or atrophy.

  17. Tnterobserver variation in histopathological assessment of Helicobacter pylori gastritis

    Institute of Scientific and Technical Information of China (English)

    Ozlem Aydin; Reyhan Egilmez; Tuba Karabacak; Arzu Kanik

    2003-01-01

    Because the presence or absence of H pylori infection has important implications for therapeutic decisions based on histological assessment, the reproducibility of Sydney system is important. The study was designed to test the reproducibility of features of Helicobacter pylori gastritis,using the updated Sydney classification.METHODS: Gastric biopsies of 40 randomly selected cases of Hpylori gastritis were scored semiquantitatively by three pathologists. Variables analysed included chronic inflammation,inflammatory activity, atrophy, intestinal metaplasia, H pylori,surface epithelial damage. Κ values below 0.5 represented poor, those between 0.5 and 0.75 good and values over 0.75excellent interobserver agreement.RESULTS: The best interobserver agreement (κ=0.62) was present for intestinal metaplasia. The agreement was the poorest for evaluating atrophy (κ=0.31).CONCLUSION: Although the results of this study were in accordance with some previous studies, an excellent agreement could not be reached for any features of H pylori gastritis. This low degree of concordance is assumed to be due to the personal evaluation differences in grading the features, the lack of standardized diagnostic criteria, and the ignorance to reach a consensus about the methods to be used in grading the features of H pylori gastritis before initiating the study.

  18. Dr.Zhu Hongming's Experience in Treating Chronic Gastritis

    Institute of Scientific and Technical Information of China (English)

    朱传伟

    2004-01-01

    @@ Dr. Zhu Hongming has engaged in TCM internal medicine for more than 40 years and accumulated rich clinical experience, especially in the treatment of diseases of the spleen and stomach. The following is a brief introduction to his experience in TCM differential treatment of chronic gastritis.

  19. Ethnic difference of Helicobacter pylori gastritis: Korean and Japanese gastritis is characterized by male- and antrum-predominant acute foveolitis in comparison with American gastritis

    Institute of Scientific and Technical Information of China (English)

    Inchul Lee; Hojung Lee; Mijung Kim; Manabu Fukumoto; Shinji Sawada; Shriram Jakate; Victor E. Gould

    2005-01-01

    AIM: To investigate the clinicopathological factors underlying the ethnic differences of Helicobacter pylori gastritis and cancer.METHODS: We analyzed clinicopathological parameters of gastric biopsies having H pylori infection that were randomly selected from different ethnic populations including 147 Americans, 149 Japanese, and 181 Koreans.RESULTS: Males were predominant in Japanese and Korean populations (77.9 and 67.4% respectively) in comparison with Americans (48.3%) (P<0.001). H pylori gastritis in Koreans and Japanese was characterized by the predominant antral involvement. In the antrum,neutrophilic infiltration into the proliferative zone of pit, i,e.acute foveolitis, was more frequent in Koreans (82%) than in Japanese (71%) (P<0.05) and Americans (61%) (P<0.001).Interstitial neutrophilic infiltration, intestinal metaplasia and atrophy were also frequent in Koreans and Japanese. In the body, the prevalence of acute foveolitis was not significantly different among the populations while chronic interstitial inflammation and lymphoid follicles were more pronounced in the body of Americans than in the body of others (P<0.01).CONCLUSION: The male-, and antrum-predominant Hpylori gastritis in Koreans and Japanese is compatible with the pattern of sex and topographical distribution of gastric cancer incidence. Our data suggest that persistent acute foveolitis at the proliferative zone is a crucial step in the gastric carcinogenesis.

  20. Histological Features and Biocompatibility of Bone and Soft Tissue Substitutes in the Atrophic Alveolar Ridge Reconstruction

    Directory of Open Access Journals (Sweden)

    Carlo Maiorana

    2016-01-01

    Full Text Available The reconstruction of the atrophic alveolar ridges for implant placement is today a common procedure in dentistry daily practice. The surgical reconstruction provides for the optimization of the supporting bone for the implants and a restoration of the amount of keratinized gingiva for esthetic and functional reasons. In the past, tissue regeneration has been performed with autogenous bone and free gingival or connective tissue grafts. Nowadays, bone substitutes and specific collagen matrix allow for a complete restoration of the atrophic ridge without invasive harvesting procedures. A maxillary reconstruction of an atrophic ridge by means of tissue substitutes and its histological features are then presented.

  1. Histological Features and Biocompatibility of Bone and Soft Tissue Substitutes in the Atrophic Alveolar Ridge Reconstruction.

    Science.gov (United States)

    Maiorana, Carlo; Beretta, Mario; Rancitelli, Davide; Grossi, Giovanni Battista; Cicciù, Marco; Herford, Alan Scott

    2016-01-01

    The reconstruction of the atrophic alveolar ridges for implant placement is today a common procedure in dentistry daily practice. The surgical reconstruction provides for the optimization of the supporting bone for the implants and a restoration of the amount of keratinized gingiva for esthetic and functional reasons. In the past, tissue regeneration has been performed with autogenous bone and free gingival or connective tissue grafts. Nowadays, bone substitutes and specific collagen matrix allow for a complete restoration of the atrophic ridge without invasive harvesting procedures. A maxillary reconstruction of an atrophic ridge by means of tissue substitutes and its histological features are then presented. PMID:27022489

  2. Biological markers in Helicobacter pylori-associated gastritis and carcinoma: the value of a scoring system

    International Nuclear Information System (INIS)

    Helicobacter pylori-associated gastritis has been linked to the pathogenesis of gastric adenocarcinoma (GA), especially when assciated with intestinal metaplasia (IM) and atypia/dysplasia (A/D). We examined p53 expression, ploidy and proliferative activity and assessed H.pylori infection in relationship to IM and A/Din case of gastritis not associated with GA and in cases of GA. We examined 53 gastric biopsies from patients with gastritis not associated with GA, including patients with IM and/or A/D (n=35) and with gastritis associated with IM and/or A/D (n=21). Thirty-six distal gastrectomy specimens from patients with GA constituted a third group of patients. A scoring system that encompassed the presence or absence of H.Pylori, degree of gastritis, IM and/or A/D, p53, MIB-1prolefarative index (MPI) and ploidy was estimated in the cases of gastritis and in cancer associated mucosa (CAM) and the adenocarcinoma from patients withGA. Patients with GA had a higher median age than those with gastritis without IM and more were males (ratio 2.2:1). H.pylori was detected in 75% (40/53) of gastritis specimen and in 55% (20/36) of GA cases. There was a statistically significant difference between the incidence of gastritis without IM and/or A/D and CAM (p=0.01). p53 expression was seen in 67% of the cases (14/21) of gastritis with IM and/or A/D and only in 5% (2 cases ) of gastritis without IM (p=0.0005). A statistically significant difference in MPI was seen between CAM and GA (p=0.01) and gastritis without IM and/or A/D and gastritis with IM(p=0.004). Cases of gastritis without IM and/or or A/D has a median score of 8 while cases of gastritis with IM and/or A/D had a median score of 12 (p=0.0003). CAM had a median score of 13, which was significantly different than gastritis without IM and/or A/D(p=0.0003) The presence of IM and/or A/D can be used in H.pylori -associated gastritis as as starting point to further investigate high risk lesions. Those showing p53 expression

  3. Setting up for corpus lexicography

    OpenAIRE

    Kilgarriff Adam; Pomikálek Jan; Jakubíček Miloš; Whitelock Pete

    2012-01-01

    There are many benefits to using corpora. In order to reap those rewards, how should someone who is setting up a dictionary project proceed? We describe a practical experience of such ‘setting up’ for a new Portuguese-English, English-Portuguese dictionary being written at Oxford University Press. We focus on the Portuguese side, as OUP did not have Portuguese resources prior to the project. We collected a very large (3.5 billion word) corpus from the web, including removing all unwanted mate...

  4. Practical Evaluation and Management of Atrophic Acne Scars: Tips for the General Dermatologist

    OpenAIRE

    Fife, Douglas

    2011-01-01

    Atrophic acne scarring is an unfortunate, permanent complication of acne vulgaris, which may be associated with significant psychological distress. General dermatologists are frequently presented with the challenge of evaluating and providing treatment recommendations to patients with acne scars. This article reviews a practical, step-by-step approach to evaluating the patient with atrophic acne scars. An algorithm for providing treatment options is presented, along with pitfalls to avoid. A ...

  5. Autoradiographic investigation of proliferative processes of the gastric mucosa of patients suffering from chronic atrophic gastritis, hyperplastic mucous polypi or ulcus ventriculi

    International Nuclear Information System (INIS)

    A series of pathological changes of the gastric mucosa such as ulcers hyperplastic polypi and intestinal metaplasias are accompanied with an increased 3H-thymidine incorporation into the mucosa. This disorder of the regulation of DNA synthesis is important as to the diagnosis of stomach cancer, but it is unsuitable as screening test in early recognition

  6. Distribution of traditional Chinese medicine syndromes of chronic atrophic gastritis%慢性萎缩性胃炎中医证型分布规律

    Institute of Scientific and Technical Information of China (English)

    赵晓丹; 孙静晶; 周斌

    2015-01-01

    Objective To discuss the relationship among different TCM syndrome of CAG , relevant pathological changes and Helicobacter pylori infection .Methods 431 CAG patients were divided into 6 kinds of TCM syndromes , i.e.59 cases of liver and stomach qi stagnation syndrome , 35 cases of stagnated heat of liver and stomach syndrome , 168 cases of spleen-stomach deficiency syndrome , 52 cases of spleen-stomach damp heat syndrome , 24 cases of stomach yin deficiency syndrome and 93 cases of stomach merid-ian of blood stasis syndrome .To analysis the relationship among different syndrome , relevant pathological changes and Helicobacter pylori infection .Results (1)In the distribution of different degrees of atrophy , there were statistically significant differences among the six syndromes (P0.05).Conclusion There were correlation among TCM syndromes , pathological changes and Helicobacter pylori infection .%目的:探讨慢性萎缩性胃炎的中医证型分布与胃黏膜病理改变程度、幽门螺杆菌( H.pylori)感染的相关性。方法将431例慢性萎缩性胃炎患者辨证分为6个证型:肝胃气滞证59例,肝胃郁热证35例,脾胃虚弱证168例,脾胃湿热证52例,胃阴不足证24例,胃络瘀血证93例。分析各证型与胃黏膜病理改变程度、幽门螺杆菌感染的关系。结果(1)各中医证型在不同程度胃粘膜萎缩分布上存在显著性差异( P<0.05),其中肝胃气滞证与脾胃虚弱证、胃络瘀血证比较差异均有统计学意义(P<0.0033);(2)各中医证型在不同程度肠化生分布上存在显著性差异(P<0.05),其中,肝胃气滞证与胃络瘀血证比较存在显著性差异(P<0.0033);(3)各中医证型在不同程度异型增生分布上差异无显著性意义(P>0.05)。结论中医证型分布与胃黏膜病理改变程度、H.pylori感染有一定的相关性。

  7. Edition des Corpus areopagiticum slavicum

    Directory of Open Access Journals (Sweden)

    Dieter Fahl

    2005-12-01

    Full Text Available An Edition of the Corpus areopagiticum slavicum In the fourteenth century, the monk Isaiah of the holy Mount Athos translated the writings of pseudo-Dionysius the Areopagite (c. end of the 5th century, core texts for Eastern and Western European theological and philosophical thought, from Greek into Church Slavonic. This first Slavic translation of Dionysius’ oeuvre (“De Coelesti Hierarchia,” “De Ecclesiastica Hierarchia,” “De Divinis Nominibus,” “De Mystica Theologia,” the epistles and scholia, which played a significant role in the development of Slavic culture, Orthodox Slavic socio-political theory and praxis, is still central to the study of Slavia Orthodoxa. A working group of German and Russian scholars has completed an edition of the translator’s Church Slavonic autograph with an en face reconstruction of the Greek text used by the translator and philological commentary. A Church Slavonic-Greek and Greek-Church Slavonic dictionary of this edition, currently in preparation, plans to make the terminology used in this influential translation accessible to interdisciplinary researchers. For the first time, the Church Slavonic lexica of this corpus, a substantial part of which was coined by the translator, will be registered in an index of words and forms.

  8. Chemical gastritis after chronic bromazepam intake: a case report

    OpenAIRE

    Krakamp Bernd; Saers Thomas; Kirschberg Oliver; Brockmann Michael

    2010-01-01

    Abstract Background We describe a rare case of diffuse macroscopic discoloration and chemical gastritis due to chronic bromazepam intake. The chemical composition of pharmaceuticals has to be considered at endoscopy and it is evident that some chemical substances damage the epithelial tissue and lead to clinical symptoms. Case Presentation Endoscopy was performed in an 82-year-old patient due to gastroesophageal reflux symptoms and epigastric pain. Gastroscopy showed a hiatal hernia and a sca...

  9. [Phlegmonous gastritis. Report of a case induced by Pseudomonas aeruginosa].

    Science.gov (United States)

    Ramos Jiménez, F A; Arocena Cedrón, M G; Goikoetxea Artola, J M; Lázaro Aramburu, S; Múgica Barreiros, P

    1992-06-01

    The authors present a case of phlegmonous gastritis in a 65 year old patient. The diagnosis was made in the operating room and the treatment was conservative; no gastric resection was done. This clinical entity is interesting because it is a least frequent pathology, the pathogenic bacteria which was the cause (Pseudomona aeruginosa) has at this time not been reported in the literature, including the favorable outcome of the patient without gastric resection. PMID:1633018

  10. Risk factor analysis for metaplastic gastritis in Koreans

    Institute of Scientific and Technical Information of China (English)

    Soonami Choi; Yun Jeong Lim; Sue Kyung Park

    2006-01-01

    AIM: To conduct a retrospective study to determine the risk factors for development of metaplastic gastritis in Korean population.METHODS: The database of 113449 subjects who underwent a gastroscopy for the purpose of a regular check-up at center for health promotion, Samsung medical center during 5 years was collected and retrospectively analyzed. Among them, 5847 subjects who had endoscopically diagnosed as a metaplastic gastritis or 10076 normal as well as answered to questionnaire were included for present study. The subjects were divided into 2 groups; Group Ⅰ, normal and Group Ⅱ, metaplastic gastritis. Age, gender, Helicobacter pylori(H pylori) seropositivity, body mass index (BMI),family history of cancer, smoking, alcohol consumption,total daily calories, folate and salt intake and dietary habit (out-eating, overeating, irregular eating) were retrieved from questionnaire or electronic medical record and compared between group Ⅰ and group Ⅱ.RESULTS: The prevalence of group Ⅱ was 11%(13578/113449) increasing its prevalence with age(P= 0.000). But, there was no significant association between 2 groups in BMI, family history of cancer,alcohol consumption, total daily calories, folate and salt intake and dietary habit (out-eating, overeating, irregular eating). Old age (P=0.000), male gender (P=0.000),H pylori seropositivity (P= 0.010) and current smoker (P= 0.000) were significantly more common in group Ⅱ at multiple logistic regression model.CONCLUSION: Our data suggested that old age, male gender,Hpyloriseropositivity and smoking were risk factors for metaplastic gastritis, precancerous lesion of gastric cancer.

  11. Biopsy specimen appearances of ischaemic gastritis in splanchnic arterial insufficiency.

    OpenAIRE

    Trowell, J E; Bell, G. D.

    1998-01-01

    A 74 year old man presented with a one month history of epigastric discomfort, anorexia, weight loss, and postprandial vomiting. The diagnosis of ischaemia was made on endoscopic biopsies from the stomach and duodenum. He was too ill for major vascular surgery and died eight days after admission. Postmortem examination confirmed the diagnosis of splanchnic arterial insufficiency caused by atheroma and thrombosis. Ischaemic gastritis is rare but could easily be missed in unrepresentative biops...

  12. Inferring cultural models from corpus data

    DEFF Research Database (Denmark)

    Jensen, Kim Ebensgaard

    2015-01-01

    into the possibility of inferring cultural models from naturally occurring verbal behavior as documented in language corpora. Even rarer are such corpus-based studies of the interaction between cultural models and constructions. Exploring the usability of corpus data and methodology in the observation...

  13. Network Analysis with the Enron Email Corpus

    Science.gov (United States)

    Hardin, J. S.; Sarkis, G.; URC, P. .

    2015-01-01

    We use the Enron email corpus to study relationships in a network by applying six different measures of centrality. Our results came out of an in-semester undergraduate research seminar. The Enron corpus is well suited to statistical analyses at all levels of undergraduate education. Through this article's focus on centrality, students can explore…

  14. 32 CFR 516.20 - Habeas Corpus.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Habeas Corpus. 516.20 Section 516.20 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC RELATIONS LITIGATION Reporting Legal Proceedings to HQDA § 516.20 Habeas Corpus. (a) General. A soldier...

  15. Cell proliferation in Helicobacter pylori associated gastritis and the effect of eradication therapy.

    OpenAIRE

    Lynch, D A; Mapstone, N P; Clarke, A. M.; Sobala, G M; Jackson, P.; Morrison, L.; Dixon, M F; Quirke, P; Axon, A T

    1995-01-01

    Helicobacter pylori causes chronic (type B) gastritis. The 'intestinal' form of gastric cancer arises against a background of chronic gastritis, and prospective epidemiological studies have shown that H pylori is a major risk factor for this. An increase in mucosal cell proliferation increases the likelihood of a neoplastic clone of epithelial cells emerging where there is chronic epithelial cell injury associated with H pylori gastritis. In vitro bromodeoxyuridine labelling of endoscopic ant...

  16. Association of Helicobacter pylori infection with nodular antritis and follicular gastritis

    OpenAIRE

    Tomašević Ratko; Golubović Gradimir; Kiurski Miroslav; Stanković Dragana; Doder Radoje; Pavlović Aleksandar

    2006-01-01

    Introduction. Helicobacter pylori (H. pylori) infection is known to be the must common cause of chronic gastritis having some endoscopic and pathologic characteristies as determinated by the Sydney System for Gastritis Classification. The aim of our case report was to point out the relationship between an endoscopic finding of nodular antritis and the presence of H. pylori infection and active chronic gastritis. Case report. Our patient underwent upper gastrointestinal endoscopy for dyspeptic...

  17. Helicobacter pylori-Induced Chronic Gastritis and Assessing Risks for Gastric Cancer

    OpenAIRE

    Gonzalo Carrasco; Corvalan, Alejandro H.

    2013-01-01

    Chronic gastritis is an inflammation of the gastric mucosa and has multiple etiologies. Here we discuss the pathological alterations induced by Helicobacter pylori (HP) leading to chronic gastritis and the epigenetic bases underlying these changes. We review the histology of the normal gastric mucosa and overview the role of HP in the multistep cascade of GC. We attempt to define the role of the Operative Link for Gastritis Assessment (OLGA) staging system in assessing the risk of GC. The epi...

  18. Brugia filariasis differentially modulates persistent Helicobacter pylori gastritis in the gerbil model

    OpenAIRE

    Martin, Heather R.; Shakya, Krishna P.; MUTHUPALANI, SURESHKUMAR; Ge, Zhongming; Klei, Thomas R.; Whary, Mark T.; James G Fox

    2010-01-01

    In select Helicobacter pylori-infected populations with low gastric cancer, nematode coinfections are common and both helicobacter gastritis and filariasis are modeled in gerbils. We evaluated gastritis, worm counts, tissue cytokine gene expression levels and Th1/Th2-associated antibody responses in H. pylori and Brugia pahangi mono- and coinfected gerbils. H. pylori-associated gastritis indices were significantly lower 21 weeks post-infection in coinfected gerbils (p ≤ 0.05) and were inverse...

  19. Histology of chronic gastritis with and without duodenitis in patients with Helicobacter pylori infection.

    OpenAIRE

    Phull, P S; Price, A. B.; Stephens, J; Rathbone, B J; Jacyna, M R

    1996-01-01

    AIM: To compare the histological characteristics of Helicobacter pylori positive chronic gastritis in patients with and without associated duodenitis. METHODS: Gastric mucosal biopsy specimens were obtained from patients undergoing endoscopy for dyspepsia. Severity of gastritis and density of H pylori infection were graded according to the Sydney system. RESULTS: Of the 69 patients studied, 15 had normal histology, 22 had chronic gastritis only (77.3% H pylori positive), 21 had duodenitis (90...

  20. Lymphocytic gastritis: a newly described entity: a retrospective endoscopic and histological study.

    OpenAIRE

    Haot, J; Hamichi, L; Wallez, L; Mainguet, Paul

    1988-01-01

    Lymphocytic gastritis is a histopathological entity characterised by the accumulation of small lymphocytes in the surface and foveolar epithelium. In order to investigate the correlation between endoscopy and histology in this condition, 192 observations selected on the basis of a presumed diagnosis of erosive or varioliform gastritis were reviewed. Ninety two instances corresponded to lymphocytic gastritis, while 100 did not show any particular microscopic feature and were labelled non-speci...

  1. Detection of gastritis by /sup 99m/Tc-labeled red-blood-cell scintigraphy

    International Nuclear Information System (INIS)

    Gastritis is a common condition, with a variety of causes, that is diagnosed most often by barium upper gastrointestinal tract series or endoscopy. The authors report a case in which gastritis without active bleeding was apparent in scintiscans obtained during the evaluation of GI bleeding using /sup 99m/Tc-labeled red blood cells (TcRBC). The scintigraphic findings that suggest gastritis are described

  2. Collagenous gastritis, a new spectrum of disease in pediatric patients: two case reports

    OpenAIRE

    Suskind, David; Wahbeh, Ghassan; Murray, Karen; Christie, Dennis; Kapur, Raj P

    2009-01-01

    Collagenous gastritis is a rare gastrointestinal disorder characterized in pediatrics by abdominal pain and anemia. The literature divides collagenous gastritis into distinct pediatric-onset and adult-onset phenotypes. As opposed to pediatric form, the adult form is associated with collagenous colitis and presents clinically with voluminous non-bloody diarrhea. There are over 25 case reports of collagenous gastritis of which 10 are pediatric cases. We present two cases of pediatric onset coll...

  3. Post-immunisation gastritis and Helicobacter infection in the mouse: a long term study

    OpenAIRE

    Sutton, P.; Danon, S; Walker, M.; Thompson, L.; Wilson, J.; Kosaka, T; Lee, A.

    2001-01-01

    BACKGROUND AND AIMS—Helicobacter pylori is a major cause of peptic ulcers and gastric cancer. Vaccine development is progressing but there is concern that immunisation may exacerbate Helicobacter induced gastritis: prophylactic immunisation followed by challenge with H felis or H pylori can induce a more severe gastritis in mice than seen with infection alone. The aim of this study was to investigate the relationship between immunity to Helicobacter infection and post-immunisation gastritis.
...

  4. Classification of histological severity of Helicobacter pylori-associated gastritis by confocal laser endomicroscopy

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    AIM: To classify the histological severity of Helicobacter pylori (H. pylori) infection-associated gastritis by confocal laser endomicroscopy (CLE). METHODS: Patients with upper gastrointestinal symptoms or individuals who were screened for gastric cancer were enrolled in this study. Histological severity of H. pylori infection-associated gastritis was graded according to the established CLE criteria. Diagnostic value of CLE for histo-logical gastritis was investigated and compared with that of white light ...

  5. A Large available oral corpus: Orleans corpus 1968-2012 Un grand corpus oral disponible : le Corpus d'Orléans 1968-2012

    Directory of Open Access Journals (Sweden)

    Iris ESHKOL-TARAVELLA

    2012-11-01

    Full Text Available This article presents the building and putting online OF the oral corpus ESLO. Our purpose is to show that it is important not only to collect and make available language data and metadata but also to make explicit the whole chain of treatments. In the first part, we will present the project and the corpus, then we will specify the legal and methodological problems which determined all corpus treatments, in particular the anonymisation procedures which are required to freely make available this kind of resource. In the second part, we present different annotations made on the raw data with some examples of their use. We will explain the followed methodology which is always guided by the nature of the data and by the final objective: build a large sociolinguistic variationist oral corpus of French. Finally, we will discuss the issues of putting the corpus online.

  6. DEVELOPING AN ARABIC PLAGIARISM DETECTION CORPUS

    Directory of Open Access Journals (Sweden)

    Muazzam Ahmed Siddiqui

    2014-12-01

    Full Text Available A corpus is a collection of documents. It is a valuable resource in linguistics research to perform statistical analysis and testing hypothesis for different linguistic rules. An annotated corpus consists of documents or entities annotated with some task related labels such as part of speech tags, sentiment etc One such task is plagiarism detection that seeks to identify if a given document is plagiarized or not. This paper describes our efforts to build a plagiarism detection corpus for Arabic. The corpus consists of about 350 plagiarized – source document pairs and more than 250 documents where no plagiarism was found. The plagiarized documents consists of students submitted assignments. For each of the plagiarized documents, the source document was located from the Web and downloaded for further investigation. We report corpus statistics including number of documents, number of sentences and number of tokens for each of the plagiarized and source categories.

  7. Malignant atrophic papulosis (Köhlmeier-Degos disease - A review

    Directory of Open Access Journals (Sweden)

    Theodoridis Athanasios

    2013-01-01

    Full Text Available Abstract Definition of the disease Malignant atrophic papulosis (MAP, described independently by Köhlmeier and Degos et al., is a rare, chronic, thrombo-obliterative vasculopathy characterized by papular skin lesions with central porcelain-white atrophy and surrounding teleangiectatic rim. Epidemiology Less than 200 cases have been described in the literature. The first manifestation of MAP usually occurs between the 20th and 50th year of life. Clinical description The cutaneous clinical picture is almost pathognomonic. The histology is not consistent but in most cases it shows a wedge-shaped connective tissue necrosis in the deep corium due to a thrombotic occlusion of the small arteries. In the systemic variant, manifestations mostly occur at the intestine and central nervous system. Etiology The etiopathogenesis of the disease remains unknown, a genetic predisposition may occur. Vasculitis, coagulopathy or primary dysfunction of the endothelial cells have been implicated. Diagnostic methods Diagnosis is only based on the characteristic skin lesions. Differrential diagnosis It depends on the clinical presentation of MAP, but systemic lupus erythematosus and other connective tissue diseases need to be considered. Management No effective treatment exists for the systemic manifestations, while compounds that facilitate blood perfusion have achieved a partial regression of the skin lesions in single cases. Prognosis An apparently idiopathic, monosymptomatic, cutaneous, benign variant and a progressive, visceral one with approx. 50% lethality within 2–3 years have been reported. Systemic manifestations can develop years after the occurrence of skin lesions leading to bowel perforation and peritonitis, thrombosis of the cerebral arteries or massive intracerebral hemorrhage, meningitis, encephalitis, radiculopathy, myelitis.

  8. Effect of Helicobacter pylori infection on 24 hour intragastric acidity in patients with gastritis and duodenal ulcer.

    OpenAIRE

    Wagner, S.; Gladziwa, U; Haruma, K; Varrentrapp, M; Gebel, M

    1992-01-01

    Helicobacter pylori status, gastric histology, and 24 hour acidity were studied in 35 gastritis patients, 21 duodenal ulcer patients, and 14 subjects with normal gastric mucosa. H pylori was identified in 21 of 35 patients with chronic active gastritis and in 19 of 21 duodenal ulcer patients, but in none of those with normal gastric mucosa. Mean scores of activity of gastritis were similar in H pylori positive gastritis and duodenal ulcer patients, but were significantly lower in H pylori neg...

  9. Autoimmune gastritis and parietal cell reactivity in two children with abnormal intestinal permeability

    NARCIS (Netherlands)

    Greenwood, Deanne L. V.; Crock, Patricia; Braye, Stephen; Davidson, Patricia; Sentry, John W.

    2008-01-01

    Autoimmune gastritis is characterised by lymphocytic infiltration of the gastric submucosa, with loss of parietal and chief cells and achlorhydria. Often, gastritis is expressed clinically as cobalamin deficiency with megaloblastic anaemia, which is generally described as a disease of the elderly. H

  10. Radioimmunoassay of serum pepsinogen 1 in chronic gastritis and stomach cancer

    International Nuclear Information System (INIS)

    Blood serum in stomach cancer and chronic gastritis has been compared. A sharp decrease in pepsinogen 1 level both in cancer and gastritis patients was found as compared with healthy subjects. Pepsinogen 1 level in poorly-differentiated tumor (37.4 ng/ml) was lower than in well-differentiated one (58.2 ng/ml)

  11. Serum biomarker tests are useful in delineating between patients with gastric atrophy and normal, healthy stomach

    Institute of Scientific and Technical Information of China (English)

    Katsunori Iijima; Yasuhiko Abe; Ryosuke Kikuchi; Tomoyuki Koike; Shuichi Ohara; Pentti Sipponen; Tooru Shimosegawa

    2009-01-01

    AIM: To study the value of serum biomarker tests to differentiate between patients with healthy or diseased stomach mucosa: i.e. those with Helicobacter pylori (H pylori) gastritis or atrophic gastritis, who have a high risk of gastric cancer or peptic ulcer diseases.METHODS: Among 162 Japanese outpatients, pepsinogenⅠ(PgⅠ) and Ⅱ(Pg Ⅱ) were measuredusing a conventional Japanese technique, and the European GastroPanel examination (PgⅠand Pg Ⅱ,gastrin-17 and H pylori antibodies). Gastroscopy with gastric biopsies was performed to classify the patients into those with healthy stomach mucosa, H pylori nonatrophic gastritis or atrophic gastritis. RESULTS: Pg Ⅰ and Pg Ⅱ assays with the GastroPanel and the Japanese method showed a highly significant correlation. For methodological reasons, however, serum Pg Ⅰ, but not Pg Ⅱ, was twice as high with the GastroPanel test as with the Japanese test.The biomarker assays revealed that 5% of subjects had advanced atrophic corpus gastritis which was also verified by endoscopic biopsies. GastroPanel examination revealed an additional seven patients who had either advanced atrophic gastritis limited to the antrum or antrum-predominant H pylori gastritis.When compared to the endoscopic biopsy findings,the GastroPanel examination classified the patients into groups with "healthy" or "diseased" stomach mucosa with 94% accuracy, 95% sensitivity and 93% specificity.CONCLUSION: Serum biomarker tests can be used to differentiate between subjects with healthy and diseased gastric mucosa with high accuracy.

  12. Gastritis cystica polyposa in the unoperated stomach: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yeo Jin; Kim, Kyung Ah; Chung, Yong Eun; Lim, Joon Seok; Jeon, Hyae Min [Severance Hospital/Yonsei Univ. College of Medicine, Seoul (Korea, Republic of)

    2012-10-15

    Gastritis cystica polyposa (GCP) is an uncommon lesion that usually develops at the gastroenterostomy site. A 57 year old man visited a hospital with a complaint of melena. He did not have any surgical history or past medical history. Endoscopy was performed to evaluate the cause of melena, and a polypoid cystic mass in the stomach was found on an endoscopy and endoscopic ultrasonography. The polypoid cystic mass did not show any enhancing solid portion on a computed tomography. The gastric lesion was conclusively confirmed as GCP through endoscopic submucosal dissection. We report a rare case of GCP that occurred in an unoperated stomach.

  13. Primary Eosinophilic Gastritis in a Child with Gastric Outlet Obstruction.

    Science.gov (United States)

    Katiyar, Richa; Patne, Shashikant C U; Dixit, Vinod Kumar; Sharma, Shiv Prasad

    2016-06-01

    A 3-year-old girl presented with multiple episodes of vomiting, fever, and hematemesis for the past 2 months. Except for hemoglobin, her rests of the laboratory tests were unremarkable. Her barium X-ray showed absence of the duodenal bulb and the C-loop. Her endoscopy showed deformed stomach with multiple ulcers and diverticuli. The gastric outlet was not visualized. Distal gastrectomy with gastro-duodenal anastomosis was performed. Histopathological findings revealed transmural dense infiltrates of eosinophils, consistent with eosinophilic gastritis. PMID:26768007

  14. Gastritis cystica polyposa in the unoperated stomach: A case report

    International Nuclear Information System (INIS)

    Gastritis cystica polyposa (GCP) is an uncommon lesion that usually develops at the gastroenterostomy site. A 57 year old man visited a hospital with a complaint of melena. He did not have any surgical history or past medical history. Endoscopy was performed to evaluate the cause of melena, and a polypoid cystic mass in the stomach was found on an endoscopy and endoscopic ultrasonography. The polypoid cystic mass did not show any enhancing solid portion on a computed tomography. The gastric lesion was conclusively confirmed as GCP through endoscopic submucosal dissection. We report a rare case of GCP that occurred in an unoperated stomach

  15. Ranibizumab for choroidal neovascularization following atrophic involution of adult-onset foveomacular vitelliform dystrophy.

    Directory of Open Access Journals (Sweden)

    Sebastian Martinez-Castillo

    2013-10-01

    Full Text Available Purpose: We report a case of adult-onset foveomacular vitelliform dystrophy (AOFVD complicated with atrophic involution and subsequent choroidal neovascularization (CNV and treated with intravitreal ranibizumab. Design: Case Report Methods: A 71-year-old woman diagnosed with AOFVD experienced a progression of the vitelliform lesion to the atrophic stage in her left eye immediately after cataract surgery. Best corrected visual acuity (BCVA decreased from 0.5 to 0.16. Ten months later, the patient was referred with new worsening of her visual acuity (0.05 and metamorphopsia. The spectral-domain optical coherence tomography (SD-OCT confirmed the presence of type 2 CNV next to the atrophic area. The patient was treated with 2 monthly injections of ranibizumab. Results: SD-OCT images improved significantly and her BCVA increased to 0.20 associated with subjective improvement of metamorphopsia. Conclusion: Ranibizumab may be effective for CNV in patients with AOFVD.

  16. Corpus in Foreign Language Teaching and Research

    Directory of Open Access Journals (Sweden)

    Xin-ping ZHOU

    2006-12-01

    Full Text Available Corpus-based language research has been long prospered since the middle of last century. Corpus is therefore frequently used in foreign language (mostly English teaching and research due to the fundamental principles of modern Corpus Linguistics along with the colorful resources of word-banks and the corresponding tools, especially in western countries. In China, the related literature found its way from introducing the foreign researches to our own practice into this field. As a conclusion, corpus and Corpus Linguistics can be closely connected with and widely applied in foreign language teaching and research with a predictable bright future.
    Keywords: corpus, Corpus Linguistics, foreign language teaching and research
    Résumé Le moyen de recherches sur le corpus a connu un développement rapide depuis le milieu du siècle précédent et a atteint la maturité aujourd’hui. En raison de l’importance de la linguistique de corpus et de la méthode de recherches sur le corppus, et étant donné ses ressources riches ainsi que les facilités apportées par les outils de recherche, le corpus est appliquée amplement dans les recherches linguistiques notamment dans celles de l’anglais. A l’étranger, l’étude de la linguistique de corpus a débuté tôt et a donné beaucoup de fruits ; le travail du milieu des langues étrangères chinois dans ce domaine a commencé par la présentation du corpus étranger et sa situation d’étude, et puis procède à des applications pratiques. En somme, il existe des relations étroites et diverses entre le corpus et les recherches de l’enseignement-apprentissage des langues étrangères, et les recherches de l’enseignement-apprentissage des langues étrangères basant sur le corpus présente une bonne perspective.
    Mots-clés: corpus, linguistique de corpus, recherches de l’enseignement-apprentissage des langues étrangères
    摘 要 語料���研究方法自上個世

  17. [Medicine and astrology in Arnau's corpus].

    Science.gov (United States)

    Giralt, Sebastià

    2006-01-01

    The role of astrology in Arnau de Vilanova's medical work is revisited with special attention to the problems of authorship posed by the astrological writings of Arnau's corpus and to their hypothetical chronology. PMID:17214132

  18. Hindi Dictionaries and the Hindi Lexicographical Corpus

    Czech Academy of Sciences Publication Activity Database

    Strnad, Jaroslav

    Reinbek : Dr. Inge Wezler Verlag fur Orientalistische Fachpublikationen, 2001 - (Lönne, D.), s. 531-544 ISBN 3-88587-033-9 Institutional research plan: CEZ:AV0Z9021901 Keywords : Hindi * lexicography * corpus Subject RIV: AI - Linguistics

  19. Bayesian Stratified Sampling to Assess Corpus Utility

    OpenAIRE

    Hochberg, Judith; Scovel, Clint; Thomas, Timothy; Hall, Sam

    1998-01-01

    This paper describes a method for asking statistical questions about a large text corpus. We exemplify the method by addressing the question, "What percentage of Federal Register documents are real documents, of possible interest to a text researcher or analyst?" We estimate an answer to this question by evaluating 200 documents selected from a corpus of 45,820 Federal Register documents. Stratified sampling is used to reduce the sampling uncertainty of the estimate from over 3100 documents t...

  20. Compiling a Corpus for Teaching Medical Translation

    OpenAIRE

    Elizabeth de la Teja Bosch; Ania Mercedes Carballosa González

    2014-01-01

    Background: medical translation has countless documentary sources; the major difficulty lies in knowing how to assess them. The corpus is the ideal tool to perform this activity in a rapid and reliable way, and to define the learning objectives based on text typology and oriented towards professional practice.Objective: to compile an electronic corpus that meets the requirements of the professional practice to perform specialized medical translation. Methods: a pedagogical research was conduc...

  1. Compiling a Corpus for Teaching Medical Translation

    Directory of Open Access Journals (Sweden)

    Elizabeth de la Teja Bosch

    2014-04-01

    Full Text Available Background: medical translation has countless documentary sources; the major difficulty lies in knowing how to assess them. The corpus is the ideal tool to perform this activity in a rapid and reliable way, and to define the learning objectives based on text typology and oriented towards professional practice.Objective: to compile an electronic corpus that meets the requirements of the professional practice to perform specialized medical translation. Methods: a pedagogical research was conducted in the province of Cienfuegos. The units of analysis involved records from translators of the Provincial Medical Sciences Information Center and specialized translators in this field, who completed a questionnaire to accurately determine their information needs, conditioning the corpus design criteria. The analysis of a set of texts extracted from highly reputable sources led to the text selection and final compilation. Subsequently, the validation of the corpus as a documentary tool for teaching specialized medical translation was performed. Results: there was a concentration of translation assignments in the topics: malignant tumors, hypertension, heart disease, diabetes mellitus and pneumonias. The predominant text typologies were: evaluative and dissemination of current research, with plenty original articles and reviews. The text corpus design criteria were: unannotated, documented, specialized, monitor and comparable. Conclusions: the corpus is a useful tool to show the lexical, terminological, semantic, discursive and contextual particularities of biomedical communication. It allows defining learning objectives and translation problems. Key words: teaching; translating; medicine

  2. The Bulgarian-Polish-Russian parallel corpus

    Directory of Open Access Journals (Sweden)

    Maksim Duškin

    2015-11-01

    Full Text Available The Bulgarian-Polish-Russian parallel corpusThe Semantics Laboratory Team of Institute of Slavic Studies of Polish Academy of Sciences is planning to begin work on the creation of a Bulgarian-Polish-Russian parallel corpus. The three selected languages are representatives of the main groups of Slavic languages: Bulgarian represents the southern group of Slavic languages, Polish – the western group of Slavic languages, Russian – the eastern group of Slavic languages. Our project will be the first parallel corpus of these three languages. The planned corpus will be based on material, dating from one period (the 20th century and will have a synchronous nature. The project will not constitute the sum of the separate corpora of selected languages.One of the problems with creating multilingual parallel corpora are different proportions of translated texts between the selected languages, for example, Polish literature is often translated into Bulgarian, but not vice versa.Bulgarian, Russian and Polish differ typologically – Bulgarian is an analytic language, Polish and Russian are synthetic. The parallel corpus should have compatible annotation, while taking into account the characteristic features of the selected languages.We hope that the Bulgarian-Polish-Russian parallel corpus will serve as a source of linguistic material of contrastive language studies and may prove to be a big help for linguists, translators, terminologists and students of linguistics. The results of our work will be available on the Internet.

  3. Severely Atrophic Human Muscle Fibers With Nuclear Misplacement Survive Many Years of Permanent Denervation.

    Science.gov (United States)

    Carraro, Ugo; Kern, Helmut

    2016-06-13

    Likewise in rodents, after complete spinal cord injury (SCI) the lower motor neuron (LMN) denervated human muscle fibers lose completely the myofibrillar apparatus and the coil distribution of myonuclei that are relocated in groups (nuclear clumps) in the center of severely atrophic muscle fibers. Up to two years of LMN denervation the muscle fibers with nuclear clumps are very seldom, but in this cohort of patients the severely atrophic muscle fibers are frequent in muscle biopsies harvested three to six years after SCI. Indeed, the percentage increased to 27 ± 9% (pbehavior in long term denervated muscle fibers. PMID:27478559

  4. Microvascular endothelial cells of the corpus luteum

    Directory of Open Access Journals (Sweden)

    Spanel-Borowski Katherina

    2003-11-01

    Full Text Available Abstract The cyclic nature of the capillary bed in the corpus luteum offers a unique experimental model to examine the life cycle of endothelial cells, involving discrete physiologically regulated steps of angiogenesis, blood vessel maturation and blood vessel regression. The granulosa cells and theca cells of the developing antral follicle and the steroidogenic cells of the corpus luteum produce and respond to angiogenic factors and vasoactive peptides. Following ovulation the neovascularization during the early stages of corpus luteum development has been compared to the rapid angiogenesis observed during tumor formation. On the other end of the spectrum, the microvascular endothelial cells are the first cells to undergo apoptosis at the onset of corpus luteum regression. Important insights on the morphology and function of luteal endothelial cells have been gained from a combination of in vitro and in vivo studies on endothelial cells. Endothelial cells communicate with cells comprising the functional unit of the corpus luteum, i.e., other vascular cells, steroidogenic cells, and immune cells. This review is designed to provide an overview of the types of endothelial cells present in the corpus luteum and their involvement in corpus luteum development and regression. Available evidence indicates that microvascular endothelial cells of the corpus luteum are not alike, and may differ during the process of angiogenesis and angioregression. The contributions of vasoactive peptides generated by the luteal endothelin-1 and the renin-angiotensin systems are discussed in context with the function of endothelial cells during corpus luteum formation and regression. The ability of two cytokines, tumor necrosis factor alpha and interferon gamma, are evaluated as paracrine mediators of endothelial cell function during angioregression. Finally, chemokines are discussed as a vital endothelial cell secretory products that contribute to the recruitment of

  5. H.heilmannii与H.pylori相关性胃炎的对比研究%A comparative study of H.heilmannii-associated and H. pylori-associated gastritis

    Institute of Scientific and Technical Information of China (English)

    李静; 陈烨; 周永柏; 付祥胜; 王继德; 陈楚弟; 张亚历

    2008-01-01

    Objective To evaluate the clinical manifestations, endoscopic features and the clinical pathological characteristics of H. heilmannii-associated gastritis, and to compare these variables with those of H. pylori-ussociated gastritis. Methods The clinical data, endoscopic findings and pathologic characteristics of 3107 patients, who underwent endoscopy from 2005 to 2007, were retrospectively analyzed. Results Twenty-five cases of H. heilmannii infection were identified, the infection rates of H. heilmannii and H. pylori were 0.80% (25/3107) and 4.12% (1060/3107) respectively. Three cases were mixed infections. Of 25 patients, 20 showed such gastroenterologic symptoms to a greater or less extent as abdominal distending pain,nausea and anorexia, and other 5 cases were asymptomatic. All 25 patients showed chronic gastritis by en-doscopy, including chronic superficial gastritis (7/25, 28% ), erosion ( 3/25, 12% ), chronic atrophic gastritis (4/25, 16%), bile reflux(1/25, 4%), ulcer (1/25, 4%), polyp (1/25, 4%) and duodenal bulbar inflammation (2/25, 8% ). In rapid urease test, 3 cases were hyper-positive, 3 cases positive, 7 ca-ses mild-positive and 12 cases negative. According to histological observation, H. heilmannii scattered or ac-cumulated within the gastric pits, glandular lumen or mucus. The organism was observed in parietal cells with cell damage in one case. Sporadic lymphatic and plasmic infiltration were found in all patients with H.heilmannii infection, infiltration of neutrophils (12/25), gland atrophy and intestinal metaplasia (4/25)and lymphoid follicles (6/25) were also observed. Compared with H. pylori-associated gastritis, H. heilman-nii-associated gastritis showed less inflammation, less helicobacter density, mononuclear cell infiltration and neutrophilic activity ( P < 0.05 ). Conclusion H. heilmanaii mainly induces chronic gastritis, which is less severe than H. pylori-associated gastritis.%目的 评估上消化道H.heilmannii感染的临床表现

  6. Impairment of an atrophic mandible by preparation of the implant cavity: a biomechanical study.

    Science.gov (United States)

    Steiner, Timm; Torsiglieri, Tobias; Rau, Andrea; Möhlhenrich, Stephan C; Eichhorn, Stefan; Grohmann, Isabella; Deppe, Herbert; Hölzle, Frank; Raith, Stefan

    2016-07-01

    An important complication during insertion of implants in atrophic mandibles is the fracture that can be induced by preparation of the cavity. We designed this study to identify which configuration of cavities in the interforaminal region was the least likely to fracture. An electromechanical testing machine was used to measure breaking loads of specifically-designed synthetic models of atrophic mandibles. The implant cavities correlated with the common clinical patterns. Intact atrophied synthetic mandibles broke at a mean (SD) load of 729.48 (59.94) N (control group). Models with four different configurations of cavities fractured as follows: two short, wide cavities (8 x 4.2mm) at a mean (SD) load of 569.17 (67.7) N; two long, thin cavities (15 x2.8mm) at a load of 563.40 (62.0) N; four short, wide cavities (8 x 4.2mm) at a load of 667.01 (71.89) N; and four long, thin cavities (15 x 2.8mm) at a load of 409.50 (43.61) N. Biomechanical findings showed that there was a greater risk of fracture of atrophic mandibular models in long, thin implant cavities with more preparation sites. Each cavity prepared for an implant increased the risk of fracture in an atrophic mandible. The risk of fracture is greatest with long, thin cavities. PMID:27068851

  7. Dominant inherited distal spinal muscular atrophy with atrophic and hypertrophic calves

    NARCIS (Netherlands)

    Groen, R J; Sie, O G; van Weerden, T W

    1993-01-01

    The clinical, electrophysiological, radiological and morphological data of 3 members of a family with autosomal dominant distal spinal muscular atrophy (DSMA) are reported. One patient has the clinical picture of peroneal muscular atrophy with atrophic calves. His father and sister suffer from cramp

  8. Adaptive cytoprotection through modulation of nitric oxide in ethanol-evoked gastritis

    Institute of Scientific and Technical Information of China (English)

    Joshua Ka-Shun Ko; Chi-Hin Cho; Shiu-Kum Lam

    2004-01-01

    AIM: To assess the mechanisms of protective action by different mild irritants through maintenance of gastric mucosal integrity and modulation of mucosal nitric oxide (NO) in experimental gastritis rats.METHODS: Either 200 ml/L ethanol, 50 g/L NaCl or 0.3 mol/LHCl was pretreated to normal or 800 mL/L ethanol-induced acute gastritis Sprague-Dawley rats before a subsequent challenge with 500 mL/L ethanol. Both macroscopic lesion areas and histological damage scores were determined in the gastric mucosa of each group of animals. Besides,gastric mucosal activities of NO synthase isoforms and of superoxide dismutase, along with mucosal level of leukotriene (LT)C4 were measured.RESULTS: Macroscopic mucosal damages were protected by 200 mL/L ethanol and 50 g/L NaCl in gastritis rats.However, although 200 mL/L ethanol could protect the surface layers of mucosal cells in normal animals (protection attenuated by NG-nitro-L-arginine methyl ester), no cytoprotection against deeper histological damages was found in gastritis rats. Besides, inducible NO synthase activity was increased in the mucosa of gastritis animals and unaltered by mild irritants. Nevertheless, the elevation in mucosal LTC4 level following 500 mL/L ethanol administration and under gastritis condition was significantly reduced by pretreatment of all three mild irritants in both normal and gastritis animals.CONCLUSION: These findings suggest that the aggravated 500 mL/L ethanol-evoked mucosal damages under gastritis condition could be due to increased inducible NO and LTC4 production in the gastric mucosa. Only 200 mL/L ethanol is truly "cytoprotective" at the surface glandular level of nongastritis mucosa. Furthermore, the macroscopic protection of the three mild irritants involves reduction of LTC4 level in both normal and gastritis mucosa, implicating preservation of the vasculature.

  9. INTEGRATING CORPUS CONSULTATION IN LANGUAGE STUDIES

    Directory of Open Access Journals (Sweden)

    Angela Chambers

    2005-05-01

    Full Text Available Alongside developments in language research, the potential of corpora as a resource in language learning and teaching has been evident to researchers and teachers since the late 1960s. Despite publications which emphasise the benefits of corpus consultation for language learners (Bernardini, 2002; Kennedy & Miceli, 2001, there is little evidence to suggest that direct corpus consultation is coming to be seen as a complement or alternative to consultation of a dictionary, course book, or grammar by the majority of learners. There is thus a need for research to underpin the integration of corpora and concordancing in the language-learning environment.This study begins with an account of published research relating to course design and structure in the area of corpus consultation by language learners. The focus then narrows to the initial training of learners in corpus consultation, using as an example a course involving undergraduate students on several language degree programmes. The results of the students' consultation of the corpora are examined, including choice of search word(s, analytical skills, the problems encountered, and their evaluation of the activity. The results reveal how corpus consultation can complement traditional language-learning resources, while also raising questions concerning its integration in the language-learning environment.

  10. A case of radiation gastritis required surgical treatment in consequence of radiotherapy for recurrent ovarian cancer

    Energy Technology Data Exchange (ETDEWEB)

    Hagino, Daisuke; Arai, Yuko; Komatsu, Atsushi; Inoue, Kumiko; Takechi, Kimihiro [Ibaraki Prefectural Central Hospital, Tomobe (Japan)

    2002-12-01

    We report a case of radiation gastritis in consequence of radiotherapy for recurrent ovarian cancer. A 61-year-old woman received irradiation of a metastatic lesion of the second lumbar vertebra. Six months later she complained of fatigue and presented with severe anemia, and her diagnosis was hemorrhagic radiation gastritis. She was treated endoscopically, but that failed to control the bleeding, making it necessary to resect surgically. The incidence of radiation gastritis is very low because the stomach is rarely within the treated field, but it is of importance to be aware that the stomach is by no means more radioresistant than other organs. (author)

  11. A case of radiation gastritis required surgical treatment in consequence of radiotherapy for recurrent ovarian cancer

    International Nuclear Information System (INIS)

    We report a case of radiation gastritis in consequence of radiotherapy for recurrent ovarian cancer. A 61-year-old woman received irradiation of a metastatic lesion of the second lumbar vertebra. Six months later she complained of fatigue and presented with severe anemia, and her diagnosis was hemorrhagic radiation gastritis. She was treated endoscopically, but that failed to control the bleeding, making it necessary to resect surgically. The incidence of radiation gastritis is very low because the stomach is rarely within the treated field, but it is of importance to be aware that the stomach is by no means more radioresistant than other organs. (author)

  12. KoralQuery -- A General Corpus Query Protocol

    DEFF Research Database (Denmark)

    Bingel, Joachim; Diewald, Nils

    The task-oriented and format-driven development of corpus query systems has led to the creation of numerous corpus query languages (QLs) that vary strongly in expressiveness and syntax. This is a severe impediment for the interoperability of corpus analysis systems, which lack a common protocol. In...... this paper, we present KoralQuery, a JSON-LD based general corpus query protocol, aiming to be independent of particular QLs, tasks and corpus formats. In addition to describing the system of types and operations that KoralQuery is built on, we exemplify the representation of corpus queries in the...

  13. Corpus-Assisted Creative Writing: Introducing Intermediate Italian Learners to a Corpus as a Reference Resource

    Directory of Open Access Journals (Sweden)

    Claire Kennedy

    2010-02-01

    Full Text Available In much of the literature on the exploitation of corpora for language learning, the learners are viewed as researchers, who formulate and test their own hypotheses about language use. Having identified difficulties encountered in corpus investigations by our intermediate-level students of Italian in a previous study, we have designed a semester-long apprenticeship in corpus use which does not demand of them the high level of language proficiency, attention to detail in observation, and logical rigour that we consider necessary for rewarding work in the learner-as-researcher role. Instead, we introduce a corpus initially as an aid to the imagination in writing, and then to achieving accuracy through specific grammatical problem solving. We see this as the groundwork for subsequent development of the students’ research skills with corpus data. This paper describes the approach we have adopted to the corpus apprenticeship and reports on an evaluation of its effectiveness through case studies of three students and their use of a corpus and bilingual dictionary as reference resources when writing. Drawing on insights from the case studies, we outline a working definition of corpus-consultation literacy for our learning context and identify some refinements to be made to our apprenticeship.

  14. Digitisation and automatic alignment of the DIALOG corpus: a prosodically annotated corpus of Czech television debates

    Czech Academy of Sciences Publication Activity Database

    Peterek, Nino; Kaderka, Petr; Svobodová, Zdeňka; Havlová, Eva K.; Havlík, Martin; Klímová, Jana; Kubáčková, Patricie

    Berlin : Springer, 2007 - (Matoušek, V.; Mautner, P.), s. 607-612 ISBN 978-3-540-74627-0. ISSN 0302-9743. [ Text , Speech and Dialogue /10./. Plzeň (CZ), 03.09.2007-07.09.2007] R&D Projects: GA AV ČR KJB900610701 Grant ostatní: GA ČR(CZ) GA405/06/0589; GA MŠk(CZ) ME 838 Institutional research plan: CEZ:AV0Z90610518 Keywords : linguistic corpus * multimodal corpus * spoken language * corpus linguistics Subject RIV: AI - Linguistics

  15. Correlation between myeloid-derived suppressor cells and gastric cancer begin with chronic gastritis

    Institute of Scientific and Technical Information of China (English)

    朱立宁

    2012-01-01

    Objective To investigate the correlation between the ratio change of circulating myeloid-derived suppressor cells(MDSCs) and cellular immune function in healthy volunteers,chronic gastritis patients,gastric intraepithelial neoplasia patients and gastric cancer patients

  16. Association of Helicobacter pylori infection with nodular antritis and follicular gastritis

    Directory of Open Access Journals (Sweden)

    Tomašević Ratko

    2006-01-01

    Full Text Available Introduction. Helicobacter pylori (H. pylori infection is known to be the must common cause of chronic gastritis having some endoscopic and pathologic characteristies as determinated by the Sydney System for Gastritis Classification. The aim of our case report was to point out the relationship between an endoscopic finding of nodular antritis and the presence of H. pylori infection and active chronic gastritis. Case report. Our patient underwent upper gastrointestinal endoscopy for dyspeptic complaints and was diagnosed as having nodular antritis, but also underwent urease test and hystopathologic examination of antral mucosa, to determine the presence and density of H. pylori infection and the presence and severity of gastritis. After a course of anti H. pylori treatment, dyspepsia improved and new biopsy specimens obtained two months and six months afterwards revealed no pathological findings. Conclusion. The case report supported the association of H. pylori infection of lymphoid follicles with nodular gastric mucosis.

  17. Helicobacter pylori-induced gastritis may contribute to occurrence of postprandial symptomatic hypoglycemia.

    Science.gov (United States)

    Açbay, O; Celik, A F; Kadioğlu, P; Göksel, S; Gündoğdu, S

    1999-09-01

    In our clinical experience, postprandial symptomatic hypoglycemic (PSH) patients with H. pylori gastritis showed a substantial improvement in their hypoglycemic symptoms after the eradication of H. pylori. Therefore, in this study we have investigated whether H. pylori gastritis may contribute to the occurrence of PSH. For this purpose, we have evaluated the following parameters in 12 PSH patients with H. pylori gastritis before and one month after the eradication therapy: (1) the number and severity of PSH attacks that occurred in a one-month period using a 30-day diary, (2) the total symptom score following a mixed meal using a visual analog scale questionnaire (VASQ), and (3) the glucose and insulin responses to the mixed meal. After the eradication of H. pylori, the serum insulin responses at 30 and 60 min decreased (P VASQ decreased significantly (P < 0.001 in all). These results suggest that H. pylori gastritis may contribute to the occurrence of PSH. PMID:10505722

  18. Detection of Helicobacter spp. in the saliva of dogs with gastritis.

    Science.gov (United States)

    Jankowski, M; Spużak, J; Kubiak, K; Glińska-Suchocka, K; Biernat, M

    2016-01-01

    The aim of this study was to identify the species and determine the prevalence of gastric Helicobacter in the saliva of dogs with gastritis. The study was carried out on 30 dogs of different breeds, genders and ages, which were diagnosed with gastritis. The nested-PCR method was used to detect Helicobacter spp. in saliva. Helicobacter bacteria were found in the saliva samples of 23 (76.6%) dogs. Helicobacter heilmannii was the most commonly detected species of gastric Helicobacter spp. in canine saliva, and was found in 22 (73.3%) cases. The results indicate that gastric Helicobacter spp. occurs relatively frequently in dogs with gastritis. Moreover, the saliva of dogs with gastritis may be a source of Helicobacter spp. infection for humans and other animals. However, further studies are needed to confirm this finding as the PCR method does not distinguish active from inactive infections. PMID:27096797

  19. Epithelial cell proliferation and glandular atrophy in lymphocytic gastritis: Effect of H pylori treatment

    Institute of Scientific and Technical Information of China (English)

    Johanna M. Makinen; Seppo Niemela; Tuomo Kerola; Juhani Lehtola; Tuomo J. Karttunen

    2003-01-01

    AIM: Lymphocytic gastritis is commonly ass ociated with Helicobacter pylori infection. The presence of glandular atrophy and foveolar hyperplasia in lymphocytic gastritis suggests abnormalities in cell proliferation and differentiation,forming a potential link with the suspected association with gastric cancer. Our aim was to compare epithelial cell proliferation and morphology in H pylori associated lymphocytic gastritis and H pylori gastritis without features of lymphocytic gastritis,and to evaluate the effect of H pylori treatment.METHODS: We studied 14 lymphocytic gastritis patients with H pylori infection. For controls, we selected 14 matched dyspeptic patients participating in another treatment trial whose H pylori infection had successfully been eradicated.Both groups were treated with a triple therapy and followed up with biopsies for 6-18 months (patients) or 3 months (controls). Blinded evaluation for histopathological features was carried out. To determine the cell proliferation index,the sections were labeled with Ki-67 antibody.RESULTS: Before treatment, lymphocytic gastritis was characterized by foveolar hyperplasia (P=0.001) and glandular atrophy in the body (P=0.008), and increased proliferation in both the body (P=0.001) and antrum (P=0.002). Proliferation correlated with foveolar hyperplasia and inflammation activity. After eradication therapy, the number of intraepithelial lymphocytes decreased in the body (P=0.004)and antrum (P=0.065), remaining higher than in controls (P<0.001). Simultaneously, the proliferation index decreased in the body from 0.38 to 0.15 (P=0.043), and in the antrum from 0.34 to 0.20 (P=0.069), the antral index still being higher in lymphocytic gastritis than in controls (P=0.010).Foveolar hyperplasia and glandular atrophy in the body improved (P=0.021), reaching the non-LG level.CONCLUSION: In lymphocytic gastritis, excessive epithelial cell proliferation is predominantly present in the body, where it associates with

  20. Helicobacter pylori-related chronic gastritis as a risk factor for colonic neoplasms

    OpenAIRE

    INOUE, IZUMI; Kato, Jun; Tamai, Hideyuki; Iguchi, Mikitaka; Maekita, Takao; Yoshimura, Noriko; Ichinose, Masao

    2014-01-01

    To summarize the current views and insights on associations between Helicobacter pylori (H. pylori)-related chronic gastritis and colorectal neoplasm, we reviewed recent studies to clarify whether H. pylori infection/H. pylori-related chronic gastritis is associated with an elevated risk of colorectal neoplasm. Recent studies based on large databases with careful control for confounding variables have clearly demonstrated an increased risk of colorectal neoplasm associated with H. pylori infe...

  1. Comparison of Helicobacter spp. in Cheetahs (Acinonyx jubatus) with and without Gastritis

    OpenAIRE

    Terio, K. A.; Munson, L.; Marker, L.; Aldridge, B. M.; Solnick, J V

    2005-01-01

    Chronic gastritis causes significant morbidity and mortality in captive cheetahs but is rare in wild cheetahs despite colonization by abundant spiral bacteria. This research aimed to identify the Helicobacter species that were associated with gastritis in captive cheetahs but are apparently commensal in wild cheetahs. Helicobacter species were characterized by PCR amplification and sequencing of the 16S rRNA, urease, and cagA genes and by transmission electron microscopy of frozen or formalin...

  2. Assessment of gastroesophageal reflux disease by serodiagnosis of Helicobacter pylori-related chronic gastritis stage

    OpenAIRE

    Shotaro Enomoto; Masashi Oka; Hiroshi Ohata; Chizu Mukoubayashi; Mika Watanabe; Kosaku Moribata; Yosuke Muraki; Naoki Shingaki; Hisanobu Deguchi; Kazuki Ueda; Izumi Inoue; Takao Maekita; Mikitaka Iguchi; Kimihiko Yanaoka; Hideyuki Tamai

    2011-01-01

    AIM: To evaluate the association of Helicobacter pylori (H.pylori)-related chronic gastritis stage with upper gastrointestinal symptoms and gastroesophageal reflux disease (GERD). METHODS: Subjects underwent upper gastrointestinal endoscopy, a questionnaire using a frequency scale for symptoms of GERD (FSSG), and measurements of serum H.pylori-antibody and pepsinogen (PG) levels. They were classified into the following 4 groups in terms of H.pylori-related chronic gastritis stage: Group A (n ...

  3. Chemical gastritis induced by naproxen in the absence of Helicobacter pylori infection.

    OpenAIRE

    McCarthy, C J; McDermott, M.; Hourihane, D; O'MORAIN, C

    1995-01-01

    AIM--To evaluate the histological changes that occur in the antral mucosa of healthy male subjects before and after one week of naproxen administration, using a chemical gastritis score according to the Helicobacter pylori status. METHODS--Nineteen male subjects (mean age 31 years) underwent two endoscopies: one before and the other after one week of naproxen treatment (1 g daily). Antral biopsy specimens were assessed for the presence of H pylori infection and for chemical gastritis, defined...

  4. Quantitative assessment of histological changes in chronic gastritis after eradication of Helicobacter pylori.

    OpenAIRE

    Di Napoli, A; Petrino, R; Boero, M.; Bellis, D; Chiandussi, L

    1992-01-01

    AIMS: To evaluate the effect of 10 day triple treatment on H pylori eradication and associated gastritis. METHODS: Fifty patients with H pylori positive non-ulcer dyspepsia were treated for 10 days with amoxicillin, tinidazole, and bismuth salts. Histological examination of the antral mucosa was performed before (T0), six weeks (T1), and six months (T2) after treatment. The new Sydney classification of gastritis was used, using a score from 0 to 3 to grade degree of inflammation, atrophy, act...

  5. Macrophages Are Mediators of Gastritis in Acute Helicobacter pylori Infection in C57BL/6 Mice▿

    OpenAIRE

    Kaparakis, Maria; Walduck, Anna K.; Price, Jason D.; Pedersen, John S; van Rooijen, Nico; Pearse, Martin J.; Wijburg, Odilia L. C.; Strugnell, Richard A.

    2008-01-01

    Helicobacter pylori is the etiological agent of human chronic gastritis, a condition seen as a precursor to the development of gastrointestinal ulcers or gastric cancer. This study utilized the murine model of chronic H. pylori infection to characterize the role of macrophages in the induction of specific immune responses and gastritis and in the control of the bacterial burden following H. pylori infection and vaccination. Drug-loaded liposomes were injected intravenously to deplete macropha...

  6. Endoscopic diagnosis of cytomegalovirus gastritis after allogeneic hematopoietic stem cell transplantation

    Institute of Scientific and Technical Information of China (English)

    Yasuo; Kakugawa; Masahiro; Kami; Takahisa; Matsuda; Yutaka; Saito; Sung-Won; Kim; Takahiro; Fukuda; Shin-ichiro; Mori; Tadakazu; Shimoda; Ryuji; Tanosaki; Daizo; Saito

    2010-01-01

    AIM:To clarify the endoscopic and clinical findings of cytomegalovirus(CMV) gastritis after allogeneic hematopoietic stem cell transplantation(allo-SCT).METHODS:Between 1999 and 2005,523 patients underwent allo-SCT at our hospital,and 115 of these patients with gastrointestinal symptoms underwent esophagogastroduodenoscopy.RESULTS:CMV gastritis was diagnosed pathologically in seven patients(1.3%) with the other 108 patients serving as controls.Six of the seven patients developed positive CMV antigenemia,and...

  7. Epidemiological and Genome-Wide Association Study of Gastritis or Gastric Ulcer in Korean Populations

    OpenAIRE

    Oh, Sumin; Oh, Sejong

    2014-01-01

    Gastritis is a major disease that has the potential to grow as gastric cancer. Gastric cancer is a very common cancer, and it is related to a very high mortality rate in Korea. This disease is known to have various reasons, including infection with Helicobacter pylori, dietary habits, tobacco, and alcohol. The incidence rate of gastritis has reported to differ between age, population, and gender. However, unlike other factors, there has been no analysis based on gender. So, we examined the hi...

  8. Identification of Helicobacter pylori DNA in the mouths and stomachs of patients with gastritis using PCR.

    OpenAIRE

    Mapstone, N P; Lynch, D A; Lewis, F. A.; Axon, A T; Tompkins, D S; Dixon, M. F.; Quirke, P.

    1993-01-01

    AIMS--To determine the prevalence of Helicobacter pylori colonisation in the mouths of patients with H pylori gastritis. METHODS--A nested polymerase chain reaction test for the 16S ribosomal RNA gene of H pylori was used on saliva, dental plaque, gastric juice and gastric biopsy specimens from patients attending a dyspepsia clinic. RESULTS--Thirteen patients had histologically confirmed Helicobacter associated gastritis. Twelve of these had positive gastric aspirates by PCR. Five had at leas...

  9. Proteomic analysis reveals molecular biological details in varioliform gastritis without Helicobacter pylori infection

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    AIM:To investigate and elucidate the molecular mechanism underlying varioliform gastritis for early detection,prevention and intervention of gastric cancer.METHODS:A combination of two-dimensional gel electrophoresis and mass spectrometry was used to detect the differentially expressed proteins between varioliform gastritis and matched normal mucosa.The selected proteins were confirmed by Western blotting and reverse transcription polymerase chain reaction(RT-PCR) in additional samples and the function of s...

  10. Proteomic analysis reveals molecular biological details in varioliform gastritis without Helicobacter pylori infection

    OpenAIRE

    Lin Zhang, Yan-Hong Hou, Kai Wu, Jun-Shan Zhai, Nan Lin

    2010-01-01

    AIM: To investigate and elucidate the molecular mechanism underlying varioliform gastritis for early detection, prevention and intervention of gastric cancer.METHODS: A combination of two-dimensional gel electrophoresis and mass spectrometry was used to detect the differentially expressed proteins between varioliform gastritis and matched normal mucosa. The selected proteins were confirmed by Western blotting and reverse transcription polymerase chain reaction (RT-PCR) in additional samples a...

  11. Endoscopic features of Helicobacter pylori induced gastritis

    OpenAIRE

    Khan Mohammed; Alhomsi Zuhair; Al-Momen Sami; Ahmad Mahmuda

    1999-01-01

    It′s still controversial whether certain macroscopic endoscopic features can be used to diagnose Helicobacter pylori (HP) related gastritis. The literature dealing with this subject is confusing, because of the lack of precise terminology, no large control trials, major discrepancies in interpretations of macroscopic changes and poor correlation of the macroscopic appearance and histological finding of gastritis. We conducted a prospective study of 208 dyspeptic patients, who underwe...

  12. INCIDENCE OF HELICOBACTER PYLORI IN DENTAL PLAQUE OF SAUDI GASTRITIS PATIENTS

    OpenAIRE

    Al-Refai, Abdel-Nasser M.; Fathalla, Sami E.; Nagamani, Rambhala; Al-Momen, Sami

    2002-01-01

    Background: Helicobacter pylori (H. pylori) was identified in dental plaque, raising the possibility of future gastritis and peptic ulceration. Objective: This trial was to study the association between presence of H. pylori in dental plaque and in the stomachs of patients with gastritis; the effect of oral hygiene and periodontal condition on the stomach. Patients and Methods: Seventy-five Saudi adult dyspeptic patients, together with 60 healthy persons as control. Two samples of dental plaq...

  13. Inflation Metaphor in the TIME Magazine Corpus

    Science.gov (United States)

    Hu, Chunyu; Liu, Huijie

    2016-01-01

    A historical perspective on economy metaphor can shed new lights on economic thoughts. Based on the TIME Magazine Corpus (TMC), this paper investigates inflation metaphor over 83 years and compares findings against the economic data over the relatively corresponding period. The results show how inflation, an abstract concept and a normal economic…

  14. Corpus Callosum Size and Verbal Intelligence

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2004-09-01

    Full Text Available Quantitative MRI measurements of the sagittal surface area of the corpus callosum (CC in 72 preterm individuals tested at adolescence (14-15 years were compared with verbal skills on neuropsychological tests in a study at the Institute of Psychiatry, De Crespigny Park, London, UK.

  15. A Massive Chinese Floral Corpus Completed

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ Through the efforts of several generations of Chinese botanists over the past 50years, a massive 80-volume corpus (in 126 books) on China's flora,Flora Reipublicae Popularis Sinicae (Chinese edition), has finally been completed. This was announced at a press meeting on March 31 in Beijing.

  16. Epidemiological and genome-wide association study of gastritis or gastric ulcer in korean populations.

    Science.gov (United States)

    Oh, Sumin; Oh, Sejong

    2014-09-01

    Gastritis is a major disease that has the potential to grow as gastric cancer. Gastric cancer is a very common cancer, and it is related to a very high mortality rate in Korea. This disease is known to have various reasons, including infection with Helicobacter pylori, dietary habits, tobacco, and alcohol. The incidence rate of gastritis has reported to differ between age, population, and gender. However, unlike other factors, there has been no analysis based on gender. So, we examined the high risk factors of gastritis in each gender in the Korean population by focusing on sex. We performed an analysis of 120 clinical characteristics and genome-wide association studies (GWAS) using 349,184 single-nucleotide polymorphisms from the results of Anseong and Ansan cohort study in the Korea Association Resource (KARE) project. As the result, we could not prove a strong relation with these factors and gastritis or gastric ulcer in the GWAS. However, we confirmed several already-known risk factors and also found some differences of clinical characteristics in each gender using logistic regression. As a result of the logistic regression, a relation with hyperlipidemia, coronary artery disease, myocardial infarction, hyperlipidemia therapy, hypotensive or antihypotensive drug, diastolic blood pressure, and gastritis was seen in males; the results of this study suggest that vascular disease has a potential association with gastritis in males. PMID:25317112

  17. Dolor abdominal, dispepsia y gastritis en pediatría: Rol del Helicobacter pylori Abdominal pain, dyspepsia and gastritis in Paedriatrics: the role of Helicobacter pylori

    OpenAIRE

    Paul Harris D.; Alex Godoy F.; Ernesto Guiraldes C

    2001-01-01

    Helicobacter pylori (H. pylori), el patógeno más común del tracto gastrointestinal en seres humanos, es la causa más frecuente de gastritis crónica, está asociado etiológicamente con úlcera gastroduodenal y algunos cánceres gástricos. La creciente acumulación de información ha hecho necesario reevaluar los conceptos de gastritis, dolor abdominal y dispepsia en pediatría, por lo que el objetivo de esta revisión fue actualizar estos conceptos enfatizando la relación de estas entidades y discuti...

  18. An annotated corpus for the analysis of VP ellipsis

    NARCIS (Netherlands)

    Bos, Johan; Spenader, J.

    2011-01-01

    Verb Phrase Ellipsis (VPE) has been studied in great depth in theoretical linguistics, but empirical studies of VPE are rare. We extend the few previous corpus studies with an annotated corpus of VPE in all 25 sections of the Wall Street Journal corpus (WSJ) distributed with the Penn Treebank. We an

  19. The Nordic Dialect Corpus – a joint research infrastructure

    Directory of Open Access Journals (Sweden)

    Janne Bondi Johannessen

    2011-06-01

    Full Text Available The paper describes the Nordic Dialect Corpus as of June 2010. The corpus is a tool that combines a number of useful features that together makes it a unique and very advanced resource for researchers of many fields of language search. The corpus is web-based and features full audio-visual representation linked to transcriptions and translations.

  20. Can a Graded Reader Corpus Provide "Authentic" Input?

    Science.gov (United States)

    Allan, Rachel

    2009-01-01

    In addition to their intended purpose, graded reader texts can be made into a corpus appropriate for use with lower-level learners. Here I consider using such a corpus for data-driven learning (DDL), to make this approach more accessible to intermediate level students. However, how far does grading the corpus in this way compromise the…

  1. Concept annotation in the CRAFT corpus

    Directory of Open Access Journals (Sweden)

    Bada Michael

    2012-07-01

    Full Text Available Abstract Background Manually annotated corpora are critical for the training and evaluation of automated methods to identify concepts in biomedical text. Results This paper presents the concept annotations of the Colorado Richly Annotated Full-Text (CRAFT Corpus, a collection of 97 full-length, open-access biomedical journal articles that have been annotated both semantically and syntactically to serve as a research resource for the biomedical natural-language-processing (NLP community. CRAFT identifies all mentions of nearly all concepts from nine prominent biomedical ontologies and terminologies: the Cell Type Ontology, the Chemical Entities of Biological Interest ontology, the NCBI Taxonomy, the Protein Ontology, the Sequence Ontology, the entries of the Entrez Gene database, and the three subontologies of the Gene Ontology. The first public release includes the annotations for 67 of the 97 articles, reserving two sets of 15 articles for future text-mining competitions (after which these too will be released. Concept annotations were created based on a single set of guidelines, which has enabled us to achieve consistently high interannotator agreement. Conclusions As the initial 67-article release contains more than 560,000 tokens (and the full set more than 790,000 tokens, our corpus is among the largest gold-standard annotated biomedical corpora. Unlike most others, the journal articles that comprise the corpus are drawn from diverse biomedical disciplines and are marked up in their entirety. Additionally, with a concept-annotation count of nearly 100,000 in the 67-article subset (and more than 140,000 in the full collection, the scale of conceptual markup is also among the largest of comparable corpora. The concept annotations of the CRAFT Corpus have the potential to significantly advance biomedical text mining by providing a high-quality gold standard for NLP systems. The corpus, annotation guidelines, and other associated resources are

  2. Major motor atrophic patterns in the face and neck: CT evaluation

    International Nuclear Information System (INIS)

    Cranial nerve deficits from various pathologic processes of the head and neck may result in characteristic patterns of denervation muscular atrophy. Such atrophic patterns may be clues to the location and extent of the lesion, particularly when cranial nerves are involved early in the course of the disease process. Thirty-six patients with computed tomographic (CT) evidence of muscular atrophy secondary to pathologic conditions involving the motor division of cranial nerves were examined. Five characteristic denervation muscular atrophy patterns seen on CT scans were identified. Recognition of these atrophic patterns can prevent misinterpretation of their CT appearance and direct the CT examination to the course of the compromised cranial nerve from the brainstem to its peripheral innervation

  3. Atrophic-appearing Pancreas on Magnetic Resonance Cholangiopancreatography as Initial Presentation of Cystic Fibrosis

    OpenAIRE

    Stratton, Amy; Murphy, Thomas; Laczek, Jeffrey

    2012-01-01

    Cystic fibrosis is an autosomal recessive disease typically diagnosed in early childhood secondary to pulmonary manifestations. We present the unusual case of a 20-year-old man being diagnosed with cystic fibrosis after he was incidentally noted to have an atrophic pancreas on magnetic resonance cholangiopancreatography. He had no sign of chronic pancreatitis or symptoms of exocrine pancreatic insufficiency. As pancreatic atrophy is rare in young adults, the patient was evaluated for cystic f...

  4. Impaired Translocation of GLUT4 Results in Insulin Resistance of Atrophic Soleus Muscle

    OpenAIRE

    Peng-Tao Xu; Zhen Song; Wen-Cheng Zhang; Bo Jiao; Zhi-Bin Yu

    2015-01-01

    Whether or not the atrophic skeletal muscle induces insulin resistance and its mechanisms are not resolved now. The antigravity soleus muscle showed a progressive atrophy in 1-week, 2-week, and 4-week tail-suspended rats. Hyperinsulinemic-euglycemic clamp showed that the steady-state glucose infusion rate was lower in 4-week tail-suspended rats than that in the control rats. The glucose uptake rates under insulin- or contraction-stimulation were significantly decreased in 4-week unloaded sole...

  5. Histological Features and Biocompatibility of Bone and Soft Tissue Substitutes in the Atrophic Alveolar Ridge Reconstruction

    OpenAIRE

    Carlo Maiorana; Mario Beretta; Davide Rancitelli; Giovanni Battista Grossi; Marco Cicciù; Alan Scott Herford

    2016-01-01

    The reconstruction of the atrophic alveolar ridges for implant placement is today a common procedure in dentistry daily practice. The surgical reconstruction provides for the optimization of the supporting bone for the implants and a restoration of the amount of keratinized gingiva for esthetic and functional reasons. In the past, tissue regeneration has been performed with autogenous bone and free gingival or connective tissue grafts. Nowadays, bone substitutes and specific collagen matrix a...

  6. Clinical usefulness of microsatellite instability for the prediction of gastric adenoma or adenocarcinoma in patients with chronic gastritis

    OpenAIRE

    Kashiwagi, K; Watanabe, M.(Niigata University, 950-2181, Niigata, Japan); Ezaki, T; Kanai, T; Ishii, H; Mukai, M; Hibi, T

    2000-01-01

    To assess a role of microsatellite instability (MSI) in the development of gastric adenocarcinoma or adenoma from chronic gastritis, we analysed mutations of five microsatellite loci in gastritis, adenoma and adenocarcinoma retrospectively. Gastric mucosa was biopsied from the same area in each patient at different periods and examined for MSI. Only one of 55 patients with chronic gastritis revealed MSI-H phenotype and the other 54 patients showed microsatellite stable (MSS) phenotypes. In si...

  7. Interleukin-1 Gene Polymorphisms in Chronic Gastritis Patients Infected with Helicobacter pylori as Risk Factors of Gastric Cancer Development

    OpenAIRE

    Hnatyszyn, Andrzej; Wielgus, Karolina; Kaczmarek-Rys, Marta; Skrzypczak-Zielinska, Marzena; Szalata, Marlena; Mikolajczyk-Stecyna, Joanna; Stanczyk, Jerzy; Dziuba, Ireneusz; Mikstacki, Adam; Slomski, Ryszard

    2013-01-01

    Epidemiological investigations indicated association of the Helicobacter pylori infections with the occurrence of inflammatory conditions of the gastric mucosa and development of chronic gastritis and intestinal type of gastric cancer. IL1A and IL1B genes have been proposed as key factors in determining risk of gastritis and malignant transformation. The aim of this paper was to evaluate association of interleukin-1 gene polymorphisms with chronic gastritis, atrophy, intestinal metaplasia, dy...

  8. Relevance Epistasis Network of Gastritis for Intra-chromosomes in the Korea Associated Resource (KARE) Cohort Study

    OpenAIRE

    Jeong, Hyun-hwan; Sohn, Kyung-Ah

    2014-01-01

    Gastritis is a common but a serious disease with a potential risk of developing carcinoma. Helicobacter pylori infection is reported as the most common cause of gastritis, but other genetic and genomic factors exist, especially single-nucleotide polymorphisms (SNPs). Association studies between SNPs and gastritis disease are important, but results on epistatic interactions from multiple SNPs are rarely found in previous genome-wide association (GWA) studies. In this study, we performed comput...

  9. Applying corpus methods to written academic texts: Explorations of MICUSP

    Directory of Open Access Journals (Sweden)

    Ute Römer

    2010-08-01

    Full Text Available Based on explorations of the Michigan Corpus of Upper-level Student Papers (MICUSP, the present paper provides an introduction to the central techniques in corpus analysis, including the creation and examination of word lists, keyword lists, concordances, and cluster lists. It also presents a MICUSP-based case study of the demonstrative pronoun this and the distribution and use of its attended and unattended forms in different disciplinary subsets of the corpus. The paper aims to demonstrate how corpus linguistics and corpus methods can contribute to writing research and provide fruitful insights into student academic writing.

  10. Interobserver consistency in histopathological assessment of chronic gastritis%慢性胃炎病理诊断的一致性研究

    Institute of Scientific and Technical Information of China (English)

    李新军; 付丽梅; 刘敏; 舒向芳; 李柏成; 郎志强; 李丽霞; 成建新; 常翠红

    2014-01-01

    目的 探讨采取慢性胃炎病理诊断标准培训并应用直观模拟评分法能否提高病理医师间慢性胃炎病理诊断的一致性.方法 8位病理医师对70份慢性萎缩性胃炎病理切片进行两轮读片,第一轮结束后接受《中国慢性胃炎共识意见(2012,上海)》中关于慢性胃炎病理诊断标准的培训,并在第二轮读片过程中运用直观模拟评分法.8位病理医师按工作年限和所在医院进行分组,采用Kappa分析两轮读片的慢性胃炎5项组织学改变诊断的一致性,并行对比分析.结果 8位病理医师第二轮读片对慢性胃炎5项组织学改变的总体诊断Kappa值均较第一轮读片有所提高,且5项组织学改变诊断的一致性程度也均有所提高.第二轮读片,高年资组和低年资组5项组织学改变的诊断Kappa值值差在-0.018 0~0.034 1,但5项组织学改变诊断的一致性程度均相同;同一医院组和不同医院组5项组织学改变的诊断Kappa值值差在0.0122~0.0497,其中幽门螺杆菌感染的诊断一致性程度好于不同医院组,其他4项组织学改变诊断的一致性程度均与不同医院组相同.结论 对病理医师进行《中国慢性胃炎共识意见(2012,上海)》中关于慢性胃炎病理诊断标准培训,并在读片时采用直观模拟评分法,可普遍提高病理医师间慢性胃炎病理诊断的一致性.%Objective To study the improvement of interobserver consistency in pathological diagnosis of chronic gastritis by using a visual-analog scale after the training on diagnostic criteria of chronic gastritis.Methods Eight pathologists conducted two rounds of evaluation of 70 slides with confirmed diagnosis of chronic atrophic gastritis.After the first round,every pathologist was trained with the diagnosis criteria from "Chinese consensus on chronic gastritis (2012,Shanghai)",and the visual analog scale was used in the second round.Eight pathologists were grouped by working experience and

  11. Comparison of Helicobacter pylori infection and gastric mucosal histological features of gastric ulcer patients with chronic gastritis patients

    OpenAIRE

    Zhang, Chuan; Yamada, Nobutaka; Wu, Yun-Lin; Wen, Min; Matsuhisa, Takeshi; Matsukura, Norio

    2005-01-01

    AIM: To compare Helicobacter pylori infection and gastric mucosal histological features of gastric ulcer patients with chronic gastritis patients in different age groups and from different biopsy sites.

  12. Gastritis crónica atrófica: mecanismos patogénicos por hipersensibilidad celular

    OpenAIRE

    Rosemary Recavarren Asencios; Sixto Recavarren Arce

    2002-01-01

    La Gastritis Crónica Atrófica, de alta incidencia en la infección por Helicobacter pylori, no ha tenido hasta hoy mecanismos patogénicos establecidos. La Gastritis por Helicobacter pylori, claramente relacionada a la Gastritis Crónica Activa Superficial, no ha encontrado mecanismos que la conecten con la Gastritis Crónica Atrófica. Hasta hace poco, eran consideradas por algunos autores como lesiones independientes. En el presente trabajo, se estudiaron 42 biopsias gástricas antrales o corpora...

  13. Bayesian Stratified Sampling to Assess Corpus Utility

    CERN Document Server

    Hochberg, J; Thomas, T; Hall, S; Hochberg, Judith; Scovel, Clint; Thomas, Timothy; Hall, Sam

    1998-01-01

    This paper describes a method for asking statistical questions about a large text corpus. We exemplify the method by addressing the question, "What percentage of Federal Register documents are real documents, of possible interest to a text researcher or analyst?" We estimate an answer to this question by evaluating 200 documents selected from a corpus of 45,820 Federal Register documents. Stratified sampling is used to reduce the sampling uncertainty of the estimate from over 3100 documents to fewer than 1000. The stratification is based on observed characteristics of real documents, while the sampling procedure incorporates a Bayesian version of Neyman allocation. A possible application of the method is to establish baseline statistics used to estimate recall rates for information retrieval systems.

  14. Thematic Analysis and Visualization of Textual Corpus

    CERN Document Server

    Chabi, Anja Habacha; Ahmed, Mohamed Ben

    2011-01-01

    The semantic analysis of documents is a domain of intense research at present. The works in this domain can take several directions and touch several levels of granularity. In the present work we are exactly interested in the thematic analysis of the textual documents. In our approach, we suggest studying the variation of the theme relevance within a text to identify the major theme and all the minor themes evoked in the text. This allows us at the second level of analysis to identify the relations of thematic associations in a textual corpus. Through the identification and the analysis of these association relations we suggest generating thematic paths allowing users, within the frame work of information search system, to explore the corpus according to their themes of interest and to discover new knowledge by navigating in the thematic association relations.

  15. An Automatic Collocation Extraction from Arabic Corpus

    Directory of Open Access Journals (Sweden)

    Abdulgabbar M. Saif

    2011-01-01

    Full Text Available Problem statement: The identification of collocations is very important part in natural language processing applications that require some degree of semantic interpretation such as, machine translation, information retrieval and text summarization. Because of the complexities of Arabic, the collocations undergo some variations such as, morphological, graphical, syntactic variation that constitutes the difficulties of identifying the collocation. Approach: We used the hybrid method for extracting the collocations from Arabic corpus that is based on linguistic information and association measures. Results: This method extracted the bi-gram candidates of Arabic collocation from corpus and evaluated the association measures by using the n-best evaluation method. We reported the precision values for each association measure in each n-best list. Conclusion: The experimental results showed that the log-likelihood ratio is the best association measure that achieved highest precision.

  16. DEVELOPING AN ONLINE CORPUS OF FORMOSAN LANGUAGES

    Directory of Open Access Journals (Sweden)

    Li-May Sung

    2008-12-01

    Full Text Available Information technologies have now matured to the point of enabling researchers to create a repository of language resources, especially for those languages facing the crisis of endangerment. The development of an online platform of corpora, made possible by recent advances in data storage, character-encoding and web technology, has profound consequences for the accessibility, quantity, quality and interoperability of linguistic field data. This is of particular significance for Formosan languages in Taiwan, many of which are on the verge of extinction. As a response to the recognition of this burgeoning problem, the key objectives of the establishment of the NTU Corpus of Formosan Languages aim to document and thus preserve valuable linguistic data, as well as relevant ethnological and cultural information. This paper will introduce some of the theoretical bases behind this initiative, as well as the procedures, transcription conventions, database normalization, in-house system and three special features in the creation of this corpus.

  17. Corpus-Based Word Sense Disambiguation

    CERN Document Server

    Fujii, A

    1998-01-01

    Resolution of lexical ambiguity, commonly termed ``word sense disambiguation'', is expected to improve the analytical accuracy for tasks which are sensitive to lexical semantics. Such tasks include machine translation, information retrieval, parsing, natural language understanding and lexicography. Reflecting the growth in utilization of machine readable texts, word sense disambiguation techniques have been explored variously in the context of corpus-based approaches. Within one corpus-based framework, that is the similarity-based method, systems use a database, in which example sentences are manually annotated with correct word senses. Given an input, systems search the database for the most similar example to the input. The lexical ambiguity of a word contained in the input is resolved by selecting the sense annotation of the retrieved example. In this research, we apply this method of resolution of verbal polysemy, in which the similarity between two examples is computed as the weighted average of the simi...

  18. Thematic Analysis And Visualization Of Textual Corpus

    Directory of Open Access Journals (Sweden)

    Anja Habacha Chabi

    2011-12-01

    Full Text Available The semantic analysis of documents is a domain of intense research at present. The works in this domaincan take several directions and touch several levels of granularity. In the present work we are exactlyinterested in the thematic analysis of the textual documents. In our approach, we suggest studying thevariation of the theme relevance within a text to identify the major theme and all the minor themes evokedin the text. This allows us at the second level of analysis to identify the relations of thematic associationsin a textual corpus. Through the identification and the analysis of these association relations we suggestgenerating thematic paths allowing users, within the frame work of information search system, to explorethe corpus according to their themes of interest and to discover new knowledge by navigating in thethematic association relations.

  19. The VGLC: The Video Game Level Corpus

    OpenAIRE

    Summerville, Adam James; Snodgrass, Sam; Mateas, Michael; Ontañón, Santiago

    2016-01-01

    Levels are a key component of many different video games, and a large body of work has been produced on how to procedurally generate game levels. Recently, Machine Learning techniques have been applied to video game level generation towards the purpose of automatically generating levels that have the properties of the training corpus. Towards that end we have made available a corpora of video game levels in an easy to parse format ideal for different machine learning and other game AI researc...

  20. Concept annotation in the CRAFT corpus

    OpenAIRE

    Bada Michael; Eckert Miriam; Evans Donald; Garcia Kristin; Shipley Krista; Sitnikov Dmitry; Baumgartner William A; Cohen K; Verspoor Karin; Blake Judith A; Hunter Lawrence E

    2012-01-01

    Abstract Background Manually annotated corpora are critical for the training and evaluation of automated methods to identify concepts in biomedical text. Results This paper presents the concept annotations of the Colorado Richly Annotated Full-Text (CRAFT) Corpus, a collection of 97 full-length, open-access biomedical journal articles that have been annotated both semantically and syntactically to serve as a research resource for the biomedical natural-language-processing (NLP) community. CRA...

  1. The constitution of the corpus of research

    OpenAIRE

    Reinoldo Marquezan

    2009-01-01

    This study will reflect on the construction of an object of research: the discursive corpus of analysis from the file constituted by the Special Education law. It is anchored in the theoretical device of the french discourse analysis inaugurated by Michel Pêcheux. The construction of a research object requires the consideration of some factors: object, question and research problem. It requires a broad preliminary exploration of the subject to insert the research in a theoretical chart settin...

  2. From Business Corpus to Business Lexicon*

    OpenAIRE

    Li Lan; Grahame T. Bilbow

    2011-01-01

    Abstract: Language corpora are now indispensable to dictionary compilation. They help broaden the role of the dictionary from standardizing the vocabulary to recording a language. The trilingual corpus generated by the Hong Kong Polytechnic University gives a record of business languages used in Hong Kong. It differs from other corpora in that (1) it includes English, Chinese and Japanese; (2) it shows local characteristics; and (3) it focuses on a specific area (financial services, ...

  3. Ruptured corpus luteal cyst: CT findings

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Hyuck Jae; Kim, Seung Hyup; Kim, Sun Ho; Kim, Hyo Cheol; Park, Chang Min; Lee, Hak Jong; Moon, Min Hoan; Jeong, Jun Yong [Seoul National University Hospital, Seoul (Korea, Republic of)

    2003-03-01

    To evaluate the CT findings of ruptured corpus luteal cysts. Six patients with a surgically proven ruptured corpus luteal cyst were included in this series. The prospective CT findings were retrospectively analyzed in terms of the size and shape of the cyst, the thickness and enhancement pattern of its wall, the attenuation of its contents, and peritoneal fluid. The mean diameter of the cysts was 2.8 (range, 1.5-4.8) cm; three were round and three were oval. The mean thickness of the cyst wall was 4.7 (range, 1-10) mm; in all six cases it showed strong enhancement, and in three was discontinuous. In five of six cases, the cystic contents showed high attenuation. Peritoneal fluid was present in all cases, and its attenuation was higher, especially around the uterus and adnexa, than that of urine present in the bladder. In a woman in whom CT reveals the presence of an ovarian cyst with an enhancing rim and highly attenuated contents, as well as highly attenuated peritoneal fluid, a ruptured corpus luteal cyst should be suspected. Other possible evidence of this is focal interruption of the cyst wall and the presence of peritoneal fluid around the adnexa.

  4. A metaphor corpus in business press headlines

    Directory of Open Access Journals (Sweden)

    Honesto Herrera Soler

    2008-04-01

    Full Text Available In linguistics a corpus typically involves a finite body of texts which are considered to be representative of a particular variety of language at a specific time (McEnery & Wilson, 2001. Those are the assumptions we have had in mind in this metaphor corpus based on business press headlines. Our body of texts is a finite number of headlines drawn from the specific field of the business sections of three newspapers: Financial Times, El País and El Mundo, published over a period running from January to July 2003. Compiling a small corpus of non-literal instantiations as different authors have done (Cortés de los Ríos, 2001; Kövecses, 2002; Charteris-Black, 2003; Koller, 2004; Deignan, 2005; and others will enable us first to identify whether the contextual meaning of a word or a multiword unit of headline contrasts with its basic meaning and whether the contextual meaning can be understood by comparison with that basic meaning, and then to categorize, both in the Spanish and in the British press, the different linguistic realizations of a headline in terms of their syntactic structure, metaphor foci and source domains.

  5. Named Entity Recognition Using Web Document Corpus

    Directory of Open Access Journals (Sweden)

    Wahiba Ben Abdessalem Karaa

    2011-02-01

    Full Text Available This paper introduces a named entity recognition approach in textual corpus. This Named Entity (NE can be a named: location, person, organization, date, time, etc., characterized by instances. A NE isfound in texts accompanied by contexts: words that are left or right of the NE. The work mainly aims at identifying contexts inducing the NE’s nature. As such, The occurrence of the word "President" in atext, means that this word or context may be followed by the name of a president as President "Obama". Likewise, a word preceded by the string "footballer" induces that this is the name of afootballer. NE recognition may be viewed as a classification method, where every word is assigned to a NE class, regarding the context. The aim of this study is then to identify and classify the contexts that are most relevant to recognize aNE, those which are frequently found with the NE. A learning approach using training corpus: web documents, constructed from learning examples is then suggested. Frequency representations andmodified tf-idf representations are used to calculate the context weights associated to context frequency, learning example frequency, and document frequency in the corpus.

  6. Tumors of the corpus callosum: imaging diagnosis

    International Nuclear Information System (INIS)

    Objective: To study the imaging features of tumors in the corpus callosum. Methods: Different imaging data of 25 tumors in the corpus callosum were retrospectively analyzed. Results: Of the 25 cases, 2 cases were anaplastic astrocytomas, 7 cases were glioblastomas, 10 cases were malignant lymphomas, 1 case for each in the following tumors: low grade astrocytoma, oligodendroglioma, anaplastic oligodendroglioma, oligoastrocytoma, lipoma, and metastatic tumor. The lesion's size varied from 7 cm to 0.5 cm. These lesions were usually iso-or hypointense on T1-weighted images and hyper-in- tense on T1-weighted images with focal necrosis, and showed ring-like or 'butterfly sign' enhancement after administration of contract medium. Lipoma showed hypodensity on CT with attenuation value of -85 HU. Glioblastomas and malignant lymphomas usually infiltrated into cerebral ventricles and brain parenchyma. Conclusions: Tumors of the corpus callosum have characteristic imaging features. MRI exam before surgery is helpful for the surgical excision. (authors)

  7. Immunoglobulin gene repertoire diversification and selection in the stomach – from gastritis to gastric lymphomas

    Directory of Open Access Journals (Sweden)

    Miri eMichaeli

    2014-06-01

    Full Text Available Chronic gastritis is characterized by gastric mucosal inflammation due to autoimmune responses or infection, frequently with Helicobacter pylori. Gastritis with H. pylori background can cause gastric mucosa-associated lymphoid tissue lymphoma (MALT-L, which sometimes further transforms into diffuse large B cell lymphoma (DLBCL. However, gastric DLBCL can also be initiated de novo. The mechanisms underlying transformation into DLBCL are not completely understood. We analyzed immunoglobulin repertoires and clonal trees to investigate whether and how immunoglobulin gene repertoires, clonal diversification and selection in gastritis, gastric MALT-L and DLBCL differ from each other and from normal responses. The two gastritis types (positive or negative for H. pylori had similarly diverse repertoires. MALT-L dominant clones presented higher diversification and longer mutational histories compared with all other conditions. DLBCL dominant clones displayed lower clonal diversification, suggesting the transforming events are triggered by similar responses in different patients. These results are surprising, as we expected to find similarities between the dominant clones of gastritis and MALT-L and between those of MALT-L and DLBCL.

  8. Treatment of Chronic Gastritis by Acupuncture: A Review

    Institute of Scientific and Technical Information of China (English)

    HUANG Qin-feng; QI Li-zhen; XIAO Yuan-chun

    2005-01-01

    从<中国现代针灸信息数据库(1970~2002年)收录的40398条信息进行分析,收集93篇针灸治疗胃炎论文,涉及5325例病例中分析,总有效率为94.4%.常采用针刺,灸法,埋藏疗法,水针.常用穴为足三里,中脘,胃俞,脾俞,内关,肝俞,三阴交等,胃痛甚者加梁丘和公孙;腹胀加天枢和气海;腹泻加天枢和上巨虚;呕吐加上脘和太冲.%This paper collects and analyzes 40 398 pieces of information from Chinese Modern Acupuncture Information Database (1970- 2002). It covers 93 articles concerning the treatment of chronic gastritis by acupuncture and 5 325 subjects, the total effective rate being 94.4%. The frequent treatment methods are needling, moxibustion, burial therapy, and hydropuncture. The major acupoints are Zusanli (ST 36), Zhongwan (CV 12), Weishu (BL 21),Pishu (BL20), Neiguan (PC 6), Ganshu (BL 18), Sanyinjiao (SP 6), etc. In the presence of severe stomachache, Liangqiu (ST 34) and Gongsun (SP 4) are added; in the presence of abdominal fullness, Tianshu (ST 25) and Qihai (CV 6) are added; in the presence of diarrhea, Tianshu (ST 25) and Shangjuxu (ST 37) are added; in the presence of vomiting, Shangwan (CV 13) and Taichong (LR 3) are added.

  9. Study of the efficiency use of physical rehabilitation in patients with chronic gastritis

    Directory of Open Access Journals (Sweden)

    Kalmykov S.A.

    2014-05-01

    Full Text Available Purpose: to make physical rehabilitation program for patients with chronic gastritis type B, promotes normalization of gastric secretory function and prolong the period of remission. Objectives of the study was to assess the dynamics of gastric secretory function and functional status of the autonomic nervous system in patients with the chronic gastritis type B . Material: the study involved 37 women with a diagnosis of the chronic gastritis type B, increased acid gastric function. Results: it was established the positive influence of corrective exercises for the lower thoracic and lumbar spine, regulated breathing exercises based on the tone of the autonomic nervous system in combination with massage and diet therapy on the state of gastric secretory function. Conclusions : it is recommended to carry out therapeutic physical culture in the form of morning hygienic gymnastics, therapeutic exercises, self-study.

  10. Treatment of radiation-induced hemorrhagic gastritis with prednisolone: A case report

    Institute of Scientific and Technical Information of China (English)

    Lan Zhang; Xiao-Ying Xie; Yan Wang; Yan-Hong Wang; Yi Chen; Zheng-Gang Ren

    2012-01-01

    Radiation-induced gastritis is an infrequent cause of gastrointestinal bleeding.It is a serious complication arising from radiation therapy,and the standard treatment method has not been established.The initial injury is characteristically acute inflammation of gastric mucosa.We presented a 46-year-old male patient with hemorrhagic gastritis induced by external radiotherapy for metastatic retroperitoneal lymph node of hepatocellular carcinoma.The endoscopic examination showed diffuse edematous hyperemicmucosa with telangiectasias in the whole muscosa of the stomach and duodenal bulb.Mlultiple hemorrhagic patches with active oozing were found over the antrum.Anti-secretary therapy was initiated for hemostasis,but melena still occurred off and on.Finally,he was successfully treated by prednisolone therapy.We therefore strongly argue in favor of perdnisolone therapy to effectively treat patients with radiation-induced hemorrhagic gastritis.

  11. Creation of a new longitudinal corpus of clinical narratives.

    Science.gov (United States)

    Kumar, Vishesh; Stubbs, Amber; Shaw, Stanley; Uzuner, Özlem

    2015-12-01

    The 2014 i2b2/UTHealth Natural Language Processing (NLP) shared task featured a new longitudinal corpus of 1304 records representing 296 diabetic patients. The corpus contains three cohorts: patients who have a diagnosis of coronary artery disease (CAD) in their first record, and continue to have it in subsequent records; patients who do not have a diagnosis of CAD in the first record, but develop it by the last record; patients who do not have a diagnosis of CAD in any record. This paper details the process used to select records for this corpus and provides an overview of novel research uses for this corpus. This corpus is the only annotated corpus of longitudinal clinical narratives currently available for research to the general research community. PMID:26433122

  12. ASSESSMENT OF MICRONEEDLING THERAPY IN THE MANAGEMENT OF ATROPHIC FACIAL ACNE SCARS

    Directory of Open Access Journals (Sweden)

    Ajay

    2015-12-01

    Full Text Available STUDY BACKGROUND Post acne scars are always a challenge to treat, especially the ones which are deep seated. There are many treatment options like laser resurfacing, dermabrasion, microdermabrasion and non-ablative laser resurfacing but with considerable morbidity and interference with the daily activities of the patient in the post-treatment period. Microneedling or dermaroller therapy is one of the new treatment options in the management of acne scars with satisfactory improvement and no significant side effect. The aim of the present study is to perform an objective evaluation the efficacy of microneedling in the treatment of atrophic acne scars. MATERIALS AND METHODS Thirty patients of skin type III-V having atrophic facial acne scars presenting to our dermatology OPD. were received multiple sittings of microneedling (dermaroller treatment with an interval of 6 weeks between each session. Goodman & Baron’s acne scar grading system was used for assessment of their scars and was evaluated clinically by serial photography at the start as well as at two months after the conclusion of the treatment. Patients on anticoagulant therapy, of keloidal tendency, with bleeding disorders, vitiligo patients, pregnant and lactating mothers and patients with active acne lesions were excluded from the study. The duration of this study was for ten months-from January 2014 to October 2014. RESULTS Any change in the grading of scars after the end of treatment and follow-up period was noted down. The efficacy and improvement of dermaroller treatment was assessed by Goodman and Baron’s Global Acne Scarring System. Out of 30 patients, 26(80.64% patients achieved a reduction in the severity of their scarring by one or two grades. Quantitative assessment showed that 13.3% of patients had minimal, 16.6% had good and 70% showed very good improvement. Adverse effects were limited to transient pain, erythema and edema. CONCLUSION Microneedling therapy seems to be

  13. Fractional CO 2 laser resurfacing as monotherapy in the treatment of atrophic facial acne scars

    Directory of Open Access Journals (Sweden)

    Imran Majid

    2014-01-01

    Full Text Available Background: While laser resurfacing remains the most effective treatment option for atrophic acne scars, the high incidence of post-treatment adverse effects limits its use. Fractional laser photothermolysis attempts to overcome these limitations of laser resurfacing by creating microscopic zones of injury to the dermis with skip areas in between. Aim: The aim of the present study is to assess the efficacy and safety of fractional CO 2 laser resurfacing in atrophic facial acne scars. Materials and Methods: Sixty patients with moderate to severe atrophic facial acne scars were treated with 3-4 sessions of fractional CO 2 laser resurfacing at 6-week intervals. The therapeutic response to treatment was assessed at each follow up visit and then finally 6 months after the last laser session using a quartile grading scale. Response to treatment was labelled as ′excellent′ if there was >50% improvement in scar appearance and texture of skin on the grading scale while 25-50% response and <25% improvement were labelled as ′good′ and ′poor′ response, respectively. The overall satisfaction of the patients and any adverse reactions to the treatment were also noted. Results: Most of the patients showed a combination of different morphological types of acne scars. At the time of final assessment 6 months after the last laser session, an excellent response was observed in 26 patients (43.3% while 15 (25% and 19 patients (31.7% demonstrated a good and poor response respectively. Rolling and superficial boxcar scars responded the best while pitted scars responded the least to fractional laser monotherapy. The commonest reported adverse effect was transient erythema and crusting lasting for an average of 3-4 and 4-6 days, respectively while three patients developed post-inflammatory pigmentation lasting for 8-12 weeks. Conclusions: Fractional laser resurfacing as monotherapy is effective in treating acne scars especially rolling and superficial boxcar

  14. The Ndebele Language Corpus: A Review of Some Factors Influencing the Content of the Corpus*

    Directory of Open Access Journals (Sweden)

    Samukele Hadebe

    2011-10-01

    Full Text Available

    Abstract: The Ndebele language corpus described here is that compiled by the ALLEX Project (now ALRI at the University of Zimbabwe. It is intended to reflect as much as possible the Ndebele language as spoken in Zimbabwe. The Ndebele language corpus was built in order to provide much-needed material for the study of the Ndebele language with a special focus on dictionarymaking and research. Like most corpora, the Ndebele language corpus may in future be used for other purposes not thought of at the time of its inception. It has been designed to meet generally acceptable standards so that it can be adaptable to various possible uses by various researchers. The article wants to outline the building process of the Ndebele language corpus with special emphasis on the challenges that faced compilers, and possible solutions. It is assumed that some of these challenges might not be peculiar to Ndebele alone but could also affect related African languages in a more or less similar situation. The main focus of the discussion will be the composition of the Ndebele language corpus, i.e. the type of texts that constitute the corpus. The corpus is composed of published texts, unpublished texts and oral material gathered from Ndebele-speaking districts of Zimbabwe. It will be argued that the use of the corpus and its reliability for research depends among other factors on its contents. It will also be shown that the contents of a corpus depend on a number of factors, some of which include sociolinguistic, political and economic considerations. These considerations have implications on both the content and quality of published and oral texts that constitute the Ndebele language corpus.

    Keywords: CORPUS, ORAL MATERIALS, CODE-MIXING, CODE-SWITCHING, MOTHER- TONGUE, NDEBELE

    Opsomming: Die Ndebeletaalkorpus: 'n Oorsig van sommige faktore wat die inhoud van die korpus be?nvloed. Die Ndebeletaalkorpus wat hier beskryf word, is di? saamgestel deur die

  15. The YLI-MED Corpus: Characteristics, Procedures, and Plans

    OpenAIRE

    Bernd, Julia; Borth, Damian; Elizalde, Benjamin; Friedland, Gerald; Gallagher, Heather; Gottlieb, Luke; Janin, Adam; Karabashlieva, Sara; Takahashi, Jocelyn; Won, Jennifer

    2015-01-01

    The YLI Multimedia Event Detection corpus is a public-domain index of videos with annotations and computed features, specialized for research in multimedia event detection (MED), i.e., automatically identifying what's happening in a video by analyzing the audio and visual content. The videos indexed in the YLI-MED corpus are a subset of the larger YLI feature corpus, which is being developed by the International Computer Science Institute and Lawrence Livermore National Laboratory based on th...

  16. On Automating and Standardising Corpus Callosum Analysis in Brain MRI

    DEFF Research Database (Denmark)

    Stegmann, Mikkel Bille; Skoglund, Karl

    2005-01-01

    Corpus callosum analysis is influenced by many factors. The effort in controlling these has previously been incomplete and scattered. This paper sketches a complete pipeline for automated corpus callosum analysis from magnetic resonance images, with focus on measurement standardisation. The...... presented pipeline deals with i) estimation of the mid-sagittal plane, ii) localisation and registration of the corpus callosum, iii) parameterisation and representation of its contour, and iv) means of standardising the traditional reference area measurements....

  17. Therapeutic effect of Streptococcus thermophilus CRL 1190-fermented milk on chronic gastritis

    Institute of Scientific and Technical Information of China (English)

    Cecilia; Rodríguez; Marta; Medici; Fernanda; Mozzi; Graciela; Font; de; Valdez

    2010-01-01

    AIM: To investigate the potential therapeutic effect of exopolysaccharide (EPS)-producing Streptococcus thermophilus (S. thermophilus) CRL 1190 fermented milk on chronic gastritis in Balb/c mice. METHODS: Balb/c mice were fed with the fermented milk for 7 d after inducing gastritis with acetyl-salicylic acid (ASA, 400 mg/kg body weight per day for 10 d). Omeprazole was included in this study as a positive therapeutic control. The gastric in? ammatory activity was evaluated from gastric histology and in? amm...

  18. [The use of the multivitamin preparation Supradin in treating patients with chronic gastritis and peptic ulcer].

    Science.gov (United States)

    Novoderzhkina, Iu G; Cherentsov, A M

    1992-08-01

    The content of ascorbin acid and thiamin was assessed in the food ration of 36 patients with chronic gastritis and ulcer disease. By the end treatment including dietotherapy these vitamins showed a deficit. Correction of this deficit of the above mentioned vitamins with a polyvitamine drug "Supradin" allowed to improve significantly the biochemical indices and availability of ascorbic acid and thiamin in patients with chronic gastritis and ulcer disease. The treatment produced a favourable effect on the clinical course of the disease, reduction of the pain syndrome and earlier recovery. PMID:1475934

  19. Divergent Approaches to Corpus Processing: The Need for Standardisation

    Directory of Open Access Journals (Sweden)

    Esau Mangoya

    2011-10-01

    Full Text Available Abstract: This article discusses some problems encountered in the processing of the Shona corpus. Most of the problems deal with the handling of adoptives, punctuation and individuals' idiolects. It also discusses the problem ensuing from an attempt to standardise the formats used in the handling of the corpus. The way a corpus is processed is critical in determining its quality. This article aims to show how the different lin-guistic backgrounds of the processors affect the appreciation of some vital aspects of the corpus. One of the acclaimed advantages of a corpus is that it allows research to be done on natural language. An ideal corpus should be a body of texts combined in a principled way to become a reliable language bank from which researchers retrieve data for various research purposes. With a good corpus, data can be provided giving an authoritative body of linguistic evidence which can support generalisations and against which hypotheses can be tested. As this proves the invaluable status of a corpus, the article assesses the processing of the Shona corpus and discusses how some aspects of the processing may impact negatively on its quality.

  20. The Need for a Speech Corpus

    OpenAIRE

    Campbell, Dermot; McDonnell, Ciaran; Meinardi, Marty; Richardson, Bunny

    2007-01-01

    This paper outlines the ongoing construction of a speech corpus for use by applied linguists and advanced EFL/ESL students. The first section establishes the need for improvements in the teaching of listening skills and pronunciation practice for EFL/ESL students. It argues for the need to use authentic native-to-native speech in the teaching/learning process so as to promote social inclusion and contextualises this within the literature, based mainly on the work of Swan, Brown and McCarthy. ...

  1. MR-billeddiagnostik af corpus pineale

    DEFF Research Database (Denmark)

    Langevad, Line; Gøbel Madsen, Camilla; Siebner, Hartwig R.; Garde, Ellen

    2014-01-01

    Tilgængeligheden af højopløselige MR-teknikker har ført til større opmærksomhed på og nye spørgsmål vedrørende corpus pineales (CP) funktion og kliniske betydning. Dertil kommer en stigende interesse for hormonet melatonins kliniske betydning og relation til forandringer i CP. I denne statusartikel...... fokuseres der på ikkeneoplastiske forandringer i CP, aktuel viden fra patologi- og MR-studier samt skanningspraksis....

  2. Dynamic corpus cavernosography: Effect of papaverine

    International Nuclear Information System (INIS)

    Twenty impotent men were studied by dynamic corpus cavernosography before and after intracavernous administration of papaverine (ICP). After ICP, artificial erections occurred and could be maintained at lower flow rates in 17 subjects. The cavernosograms of these men showed a reduction in the total number of effluent veins and an increase in filling and size of the corpora. These observations suggest that a venous occlusive mechanism plays an important role during erection. It is likely that the location of this obstructing mechanism is below or within the tunica abluginea. Identification of the absence of this obstructing mechanism is important in the management of impotence

  3. Corpus koiné de habla infantil

    OpenAIRE

    Fernández Pérez, Milagros

    2006-01-01

    Fuente de datos de habla infantil, tratados y sistematizados por sus rasgos (fónicos, gramaticales, léxicos y pragmáticos). Es un repertorio de propiedades de lengua evolutiva. Disponible en 2ª edición de 2014 en la que se han refinado e implementado rasgos relevantes en el habla infantil temprana.El corpus koiné de habla infantil contiene datos de desarrollo de la lengua(española y, en menor medida, gallega) suficientemente ilustrativos de la eficacia comunicativa del lenguaje ev...

  4. Afasia: Corpus mixto de lenguaje conversacional

    OpenAIRE

    Hernández Sacristán, Carlos; Serra Alegre, Enric; Veyrat Rigat, Montserrat

    2007-01-01

    Se ofrece en este estudio una muestra representativa de lenguaje conversacional integrada por siete conversaciones mantenidas por otros tantos sujetos afásicos con interlocutores que son familiares próximos y/o miembros del Grupo de Investigación en Neurolingüística y Lingüística Clínica de la Universitat de València. El conjunto se integra en el Corpus PerLA (ISBN obra completa 978-84-370-6250-1, del año 2005) que viene elaborando el referido equipo de investigación desde el año 2000 para da...

  5. Creating a Live, Public Short Message Service Corpus: The NUS SMS Corpus

    CERN Document Server

    Chen, Tao

    2011-01-01

    Short Message Service (SMS) messages are largely sent directly from one person to another from their mobile phones. They represent a means of personal communication that is an important communicative artifact in our current digital era. As most existing studies have used private access to SMS corpora, comparative studies using the same raw SMS data has not been possible up to now. We describe our efforts to collect a public SMS corpus to address this problem. We use a battery of methodologies to collect the corpus, paying particular attention to privacy issues to address contributors’ concerns. Our live project collects new SMS message submissions, checks their quality and adds the valid messages, releasing the resultant corpus as XML and as SQL dumps, along with corpus statistics, every month. We opportunistically collect as much metadata about the messages and their sender as possible, so as to enable different types of analyses. To date, we have collected about 60,000 messages, focusing on English and...

  6. Gastritis crónica antral por Helicobacter pylori en la infancia Chronic antral gastritis induced by Helicobacter pylori in children

    OpenAIRE

    Martha M. Gámez Escalona; Agustín M. Mulet Pérez; Zulma Miranda Moles; Agustín M. Mulet Gámez

    2008-01-01

    INTRODUCCIÓN. La investigación tiene como objetivos conocer la frecuencia de infección por Helicobacter pylori en los niños con gastritis crónica antral, estimar las diferencias en el comportamiento histológico de esta entidad en los niños con infección por Helicobacter pylori y sin ella, e identificar la posible relación entre la edad y las características histológicas de la gastritis crónica antral por Helicobacter pylori. MÉTODO. Se tomó como universo de estudio la totalidad de biopsias gá...

  7. Dolor abdominal, dispepsia y gastritis en pediatría: Rol del Helicobacter pylori Abdominal pain, dyspepsia and gastritis in Paedriatrics: the role of Helicobacter pylori

    Directory of Open Access Journals (Sweden)

    Paul Harris D.

    2001-03-01

    Full Text Available Helicobacter pylori (H. pylori, el patógeno más común del tracto gastrointestinal en seres humanos, es la causa más frecuente de gastritis crónica, está asociado etiológicamente con úlcera gastroduodenal y algunos cánceres gástricos. La creciente acumulación de información ha hecho necesario reevaluar los conceptos de gastritis, dolor abdominal y dispepsia en pediatría, por lo que el objetivo de esta revisión fue actualizar estos conceptos enfatizando la relación de estas entidades y discutir la evidencia disponible para promover una buena práctica clínica, al respecto. La asociación entre la infección por H. pylori y otras condiciones, como dolor abdominal recurrente y dispepsia no ulcerosa, no ha sido demostrada y es más bien especulativa. El H. pylori es considerado un patógeno, porque, entre otras características, cumple cada uno de los postulados de Koch como causante de gastritis crónica; en efecto, H. pylori juega un rol crítico y necesario en la patogénesis de la gastritis crónica activa. El papel de H. pylori como causa de úlcera péptica en adultos ha sido bien establecido. Aunque en niños las evidencias no son tan potentes, sí son altamente sugerentes. Aun cuando la mayoría de la población mundial está colonizada por H. pylori, solo una pequeña proporción tendrá manifestaciones clínicas producidas por la infección. Aproximadamente el 10% de ellos desarrollará úlcera péptica a lo largo de su vida, y las personas infectadas tendrán un incremento de 2 a 6 veces en el riesgo de desarrollar cáncer y linfoma tipo MALT (tejido linfoide asociado a mucosas comparado con población no infectadaHelicobacter pylori (H. pylori is the most common bacterial pathogen of the gastrointestinal tract in humans and also the most common cause of chronic gastritis and is aetiologically associated with duodenal and gastric ulcer, gastric adenocarcinoma and MALT lymphoma. The explosive accumulation of published

  8. Application of multilingual corpus in contrastive studies (on the example of the Bulgarian-Polish-Lithuanian parallel corpus)

    OpenAIRE

    Ludmila Dimitrova; Violetta Koseska-Toszewa; Danuta Roszko; Roman Roszko

    2015-01-01

    Application of multilingual corpus in contrastive studies (on the example of the Bulgarian-Polish-Lithuanian parallel corpus)In this paper we present applications of a trilingual corpus in language research. Comparative and contrastive studies of Polish and Bulgarian as well as Polish and Lithuanian have been already conducted, but up to the best of our knowledge no such studies exist for Bulgarian and Lithuanian. On the one hand, it is interesting to note that two Slavic languages are compar...

  9. Caveolin-1 Protects B6129 Mice against Helicobacter pylori Gastritis

    Science.gov (United States)

    Hitkova, Ivana; Yuan, Gang; Anderl, Florian; Gerhard, Markus; Kirchner, Thomas; Reu, Simone; Röcken, Christoph; Schäfer, Claus; Schmid, Roland M.; Vogelmann, Roger; Ebert, Matthias P. A.; Burgermeister, Elke

    2013-01-01

    Caveolin-1 (Cav1) is a scaffold protein and pathogen receptor in the mucosa of the gastrointestinal tract. Chronic infection of gastric epithelial cells by Helicobacter pylori (H. pylori) is a major risk factor for human gastric cancer (GC) where Cav1 is frequently down-regulated. However, the function of Cav1 in H. pylori infection and pathogenesis of GC remained unknown. We show here that Cav1-deficient mice, infected for 11 months with the CagA-delivery deficient H. pylori strain SS1, developed more severe gastritis and tissue damage, including loss of parietal cells and foveolar hyperplasia, and displayed lower colonisation of the gastric mucosa than wild-type B6129 littermates. Cav1-null mice showed enhanced infiltration of macrophages and B-cells and secretion of chemokines (RANTES) but had reduced levels of CD25+ regulatory T-cells. Cav1-deficient human GC cells (AGS), infected with the CagA-delivery proficient H. pylori strain G27, were more sensitive to CagA-related cytoskeletal stress morphologies (“humming bird”) compared to AGS cells stably transfected with Cav1 (AGS/Cav1). Infection of AGS/Cav1 cells triggered the recruitment of p120 RhoGTPase-activating protein/deleted in liver cancer-1 (p120RhoGAP/DLC1) to Cav1 and counteracted CagA-induced cytoskeletal rearrangements. In human GC cell lines (MKN45, N87) and mouse stomach tissue, H. pylori down-regulated endogenous expression of Cav1 independently of CagA. Mechanistically, H. pylori activated sterol-responsive element-binding protein-1 (SREBP1) to repress transcription of the human Cav1 gene from sterol-responsive elements (SREs) in the proximal Cav1 promoter. These data suggested a protective role of Cav1 against H. pylori-induced inflammation and tissue damage. We propose that H. pylori exploits down-regulation of Cav1 to subvert the host's immune response and to promote signalling of its virulence factors in host cells. PMID:23592983

  10. Corpus callosum. Landmark of the origin of cerebral diseases; Corpus callosum. Landmarke fuer die Genese zerebraler Erkrankungen

    Energy Technology Data Exchange (ETDEWEB)

    Hattingen, E.; Blasel, S.; Zanella, F.E. [Johann-Wolfgang-Goethe-Universitaet Frankfurt/Main, Institut fuer Neuroradiologie, Frankfurt (Germany); Nichtweiss, M. [HANSE-Klinikum Wismar GmbH, Klinik fuer Neurologie, Wismar (Germany); Weidauer, S. [Johann-Wolfgang-Goethe-Universitaet Frankfurt/Main, Institut fuer Neuroradiologie, Frankfurt (Germany); St.-Katharinen-Krankenhaus Frankfurt, Klinik fuer Neurologie, Frankfurt (Germany)

    2010-02-15

    Diseases of the corpus callosum include developmental disorders, immunomodulated CNS diseases, vascular malformations, disturbances of metabolism including the electrolyte homeostasis, secondary degenerations and mechanical injuries. This report provides information on the differential diagnosis of reversible and irreversible pathological changes of the corpus callosum with special focus on the localization, which often allows conclusions on the pathogenesis to be drawn. (orig.) [German] Krankhafte Veraenderungen des Corpus callosum umfassen Entwicklungsstoerungen, immunmodulierende ZNS-Erkrankungen, vaskulaere Fehlbildungen, metabolische Stoerungen einschliesslich der Elektrolythomoeostase, sekundaere Degenerationen und mechanische Traumatisierung. Der vorliegende Beitrag befasst sich mit der differenzialdiagnostischen Einordnung von reversiblen und irreversiblen Veraenderungen des Corpus callosum unter Beruecksichtigung ihrer Lokalisation, welche oft Rueckschluesse auf die Pathogenese zulaesst. (orig.)

  11. Efficacy of fractional CO2 laser in treatment of atrophic scar of cutaneous leishmaniasis.

    Science.gov (United States)

    Banihashemi, Mahnaz; Nahidi, Yalda; Maleki, Masoud; Esmaily, Habibollah; Moghimi, Hamid Reza

    2016-05-01

    Cutaneous leishmaniasis is an endemic disease in Iran. Unfortunately, it can lead to unsightly atrophic scars with limited treatment options. Fractional CO2 laser is accepted for treatment of atrophic acne scars and recently has been used to treat cutaneous leishmaniasis, so we planned to use fractional CO2 laser on leishmaniasis scar. We conducted this study on 60 leishmaniasis scars on the face of 40 patients. The lesions were treated by a fractional CO2 laser with beam size of 120 μm, with energy of 50-90 mJ, and 50-100 spots/cm(2) density with two passes in three monthly sessions. Evaluation was done in the first and second months after the first treatment and 3 and 6 months after the last treatment. Digital photography was performed at each visit. Assessment of improvement rate by patient and physician was rated separately as follows: no improvement (0 %), mild (leishmaniasis scar. No significant adverse effects were noted. PMID:26984344

  12. Progressive atrophic rhinitis in a medium-scale pig farm in Kiambu, Kenya : case report

    Directory of Open Access Journals (Sweden)

    J.K. Wabacha

    2000-07-01

    Full Text Available Forty-two pigs in a herd of 117 displayed various clinical signs of progressive atrophic rhinitis. The main signs included sneezing, coughing, lachrymation, serous to muco-purulent nasal discharge, and nasal bleeding in 1 pig. Three pigs had lateral deviation of the snout, while 4 had brachygnathia superior with obvious deformation of the face. Four acutely affected weaner pigs appeared weak, while the 7 chronically-affected pigs appeared smaller than their apparently unaffected penmates of the same age. Treatment of the acutely affected pigs with long-acting oxytetracycline at 20 mg/kg body weight intra-muscularly, repeated once after 7 days, reduced the severity but did not clear the sneezing from all the pigs. Fifteen pigs were slaughtered 2 months after the clinical diagnosis was made. The carcasses of the chronically affected pigs were about 15 % lighter than those of the apparently normal pigs of the same age and from the same pen, which translated to a loss of 921.00 Kenya shillings per pig (US$13.7. Diagnosis of progressive atrophic rhinitis was confirmed by sectioning the snouts of randomly selected slaughtered pigs with obvious deformation of the snout. Sections were madeat the level of the 1st/2nd upper premolar tooth. Varying degrees of turbinate atrophy, from mild to complete, were noted. Histopathology of the turbinates revealed metaplasia of nasal epithelium and fibrosis in the lamina propria.

  13. A two-short-implant-supported molar restoration in atrophic posterior maxilla: A finite element analysis

    Science.gov (United States)

    2016-01-01

    PURPOSE The aim of this study was to investigate the stress distribution of 2-short implants (2SIs) installed in a severely atrophic maxillary molar site. MATERIALS AND METHODS Three different diameters of internal connection implants were modeled: narrow platform (NP), regular platform (RP), and wide platform (WP). The maxillary first molars were restored with one implant or two short implants. Three 2SI models (NP-oblique, NP-vertical, and NP-horizontal) and four single implant models (RP and WP in a centered or cantilevered position) were used. Axial and oblique loadings were applied on the occlusal surface of the crown. The von Mises stress values were measured at the bone-implant, peri-implant bone, and implant/abutment complex. RESULTS The highest stress distribution at the bone-implant interface and the peri-implant bone was noticed in the RP group, and the lowest stress distribution was observed in the 2SI groups. Cantilevered position showed unfavorable stress distribution with axial loading. 2SI types did not affect the stress distribution in oblique loading. The number and installation positions of the implant, rather than the bone level, influenced the stress distribution of 2SIs. The implant/abutment complex of WP presented the highest stress concentration while that of 2SIs showed the lowest stress concentration. CONCLUSION 2SIs may be useful for achieving stable stress distribution on the surrounding bone and implant-abutment complex in the atrophic posterior maxilla.

  14. Clonally Expanding Thymocytes Having Lineage Capability in Gamma-Ray-Induced Mouse Atrophic Thymus

    International Nuclear Information System (INIS)

    Purpose: To characterize, in the setting of γ-ray-induced atrophic thymus, probable prelymphoma cells showing clonal growth and changes in signaling, including DNA damage checkpoint. Methods and Materials: A total of 111 and 45 mouse atrophic thymuses at 40 and 80 days, respectively, after γ-irradiation were analyzed with polymerase chain reaction for D-J rearrangements at the TCRβ locus, flow cytometry for cell cycle, and Western blotting for the activation of DNA damage checkpoints. Results: Limited D-J rearrangement patterns distinct from normal thymus were detected at high frequencies (43 of 111 for 40-day thymus and 21 of 45 for 80-day thymus). Those clonally expanded thymocytes mostly consisted of CD4+CD8+ double-positive cells, indicating the retention of lineage capability. They exhibited pausing at a late G1 phase of cell cycle progression but did not show the activation of DNA damage checkpoints such as γH2AX, Chk1/2, or p53. Of interest is that 17 of the 52 thymuses showing normal D-J rearrangement patterns at 40 days after irradiation showed allelic loss at the Bcl11b tumor suppressor locus, also indicating clonal expansion. Conclusion: The thymocytes of clonal growth detected resemble human chronic myeloid leukemia in possessing self-renewal and lineage capability, and therefore they can be a candidate of the lymphoma-initiating cells.

  15. Towards an event annotated corpus of Polish

    Directory of Open Access Journals (Sweden)

    Michał Marcińczuk

    2015-12-01

    Full Text Available Towards an event annotated corpus of PolishThe paper presents a typology of events built on the basis of TimeML specification adapted to Polish language. Some changes were introduced to the definition of the event categories and a motivation for event categorization was formulated. The event annotation task is presented on two levels – ontology level (language independent and text mentions (language dependant. The various types of event mentions in Polish text are discussed. A procedure for annotation of event mentions in Polish texts is presented and evaluated. In the evaluation a randomly selected set of documents from the Corpus of Wrocław University of Technology (called KPWr was annotated by two linguists and the annotator agreement was calculated. The evaluation was done in two iterations. After the first evaluation we revised and improved the annotation procedure. The second evaluation showed a significant improvement of the agreement between annotators. The current work was focused on annotation and categorisation of event mentions in text. The future work will be focused on description of event with a set of attributes, arguments and relations.

  16. Temporal Expressions in Polish Corpus KPWr

    Directory of Open Access Journals (Sweden)

    Jan Kocoń

    2015-12-01

    Full Text Available Temporal Expressions in Polish Corpus KPWrThis article presents the result of the recent research in the interpretation of Polish expressions that refer to time. These expressions are the source of information when something happens, how often something occurs or how long something lasts. Temporal information, which can be extracted from text automatically, plays significant role in many information extraction systems, such as question answering, discourse analysis, event recognition and many more. We prepared PLIMEX — a broad description of Polish temporal expressions with annotation guidelines, based on the state-of-the-art solutions for English, mainly TimeML specification. We also adapted the solution to capture the local semantics of temporal expressions, called LTIMEX. Temporal description also supports further event identification and extends event description model, focusing at anchoring events in time, ordering events and reasoning about the persistence of events. We prepared the specification, which is designed to address these issues and we annotated all documents in Polish Corpus of Wroclaw University of Technology (KPWr using our annotation guidelines.

  17. Named Entity Recognition Using Web Document Corpus

    CERN Document Server

    Karaa, Wahiba Ben Abdessalem

    2011-01-01

    This paper introduces a named entity recognition approach in textual corpus. This Named Entity (NE) can be a named: location, person, organization, date, time, etc., characterized by instances. A NE is found in texts accompanied by contexts: words that are left or right of the NE. The work mainly aims at identifying contexts inducing the NE's nature. As such, The occurrence of the word "President" in a text, means that this word or context may be followed by the name of a president as President "Obama". Likewise, a word preceded by the string "footballer" induces that this is the name of a footballer. NE recognition may be viewed as a classification method, where every word is assigned to a NE class, regarding the context. The aim of this study is then to identify and classify the contexts that are most relevant to recognize a NE, those which are frequently found with the NE. A learning approach using training corpus: web documents, constructed from learning examples is then suggested. Frequency representatio...

  18. Study on the Classification of Chronic gastritis at molecular biological level

    Institute of Scientific and Technical Information of China (English)

    Goang-Yao Yin; Wu-Ning Zhang; Xue-Fen He; Yi Chen; Xiao-Jing Shen

    2003-01-01

    .05-0.001. There were synchronous changes of gastric mucosa epithelial cellular ultrastructure. The "background lesions" (focal atrophic gastritis, focal intestinal metaplasia, micro-ulcer) in nonfocal gastric mucosa of all groups had significant differences (P<0.05-0.001).CONCLUSION: Disease with symptoms, disease without symptoms, nondisease with symptoms occur on the basis of the quantitative changes of gastric mucosa epithelial cellular ultrastructure and related bioactive substances.

  19. Defensin pattern in chronic gastritis: HBD-2 is differentially expressed with respect to Helicobacter pylori status

    OpenAIRE

    Wehkamp, J.; Schmidt, K; Herrlinger, K R; Baxmann, S; Behling, S; Wohlschläger, C; Feller, A. C.; Stange, E F; Fellermann, K

    2003-01-01

    Background/Aims: Recent reports have suggested that Helicobacter pylori infection induces the mucosal antibiotic peptide human β defensin 2 (HBD-2). Therefore, the present study investigated mRNA and peptide expression of four different defensins in the upper gastrointestinal tract in patients with H pylori positive and negative chronic gastritis.

  20. Curcuma aromatica Water Extract Attenuates Ethanol-Induced Gastritis via Enhancement of Antioxidant Status

    Directory of Open Access Journals (Sweden)

    Woo-Young Jeon

    2015-01-01

    Full Text Available Curcuma aromatica is an herbal medicine and traditionally used for the treatment of various diseases in Asia. We investigated the effects of C. aromatica water extract (CAW in the stomach of rats with ethanol-induced gastritis. Gastritis was induced in rats by intragastric administration of 5 mL/kg body weight of absolute ethanol. The CAW groups were given 250 or 500 mg of extract/kg 2 h before administration of ethanol, respectively. To determine the antioxidant effects of CAW, we determined the level of lipid peroxidation, the level of reduced glutathione (GSH, the activities of catalase, degree of inflammation, and mucus production in the stomach. CAW reduced ethanol-induced inflammation and loss of epithelial cells and increased the mucus production in the stomach. CAW reduced the increase in lipid peroxidation associated with ethanol-induced gastritis (250 and 500 mg/kg, p<0.01, resp. and increased mucosal GSH content (500 mg/kg, p<0.01 and the activity of catalase (250 and 500 mg/kg, p<0.01, resp.. CAW increased the production of prostaglandin E2. These findings suggest that CAW protects against ethanol-induced gastric mucosa injury by increasing antioxidant status. We suggest that CAW could be developed for the treatment of gastritis induced by alcohol.

  1. Pneumonia and gastritis in a cat caused by feline herpesvirus-1.

    Science.gov (United States)

    McGregor, Glenna F; Sheehan, Karen; Simko, Elemir

    2016-02-01

    We report a case of fatal respiratory and gastric herpesvirus infection in a vaccinated, adult cat with no known immunosuppression or debilitation. The disease was characterized by severe necrotizing bronchopneumonia, fibrinonecrotic laryngotracheitis, and multifocal necrotizing gastritis associated with eosinophilic intranuclear inclusion bodies and a large amount of feline herpesvirus-1 antigen detected with immunohistochemistry. PMID:26834264

  2. [Contact allergic gastritis : Rare manifestation of a metal allergy].

    Science.gov (United States)

    Pföhler, C; Vogt, T; Müller, C S L

    2016-05-01

    Only a few cases of contact allergic gastritis in patients with nickel allergy have been reported in the literature. We report a case of probable contact-allergic gastritis in a 46-year-old woman. Clinical examination revealed lichenoid mucosal lesions of the gums adjacent to a bridge and crowns that had been implanted several weeks previously. Since implantation, the patient suffered from gastrointestinal complaints including stomach pain. Gastroscopy and histological investigation of stomach biopsies showed eosinophilic gastritis. Patch testing done under the diagnosis of contact allergic stomatitis showed positive reactions to gold sodium thiosulphate, manganese (II) chloride, nickel (II) sulphate, palladium chloride, vanadium (III) chloride, zirconium (IV) chloride, and fragrances. The crowns and the bridge contained gold, palladium, and zirconium, hence they were replaced by titan-based dentition. Shortly after replacing the artificial dentition, all gastrointestinal symptoms resolved spontaneously without further treatment. Delayed-type allergy to components in the artificial dentition seem to have caused the gastritis. PMID:26909810

  3. CRYPTOSPORIDIOSIS ASSOCIATED WITH EMACIATION AND PROLIFERATIVE GASTRITIS IN A LABORATORY SOUTH AFRICAN CLAWED FROG

    Science.gov (United States)

    A 2-year-old emaciated female South African Clawed frog (Xenopus laevis) was euthanized due to chronic weight loss. At postmortem, there was no evidence of bacterial, fungal or viral disease, however, the histological findings indicated a proliferative gastritis and the presence of numerous Cryptosp...

  4. [Chronic gastritis caused by Ollulanus tricuspis (Leuckart, 1865) in a tiger].

    Science.gov (United States)

    Breuer, W; Hasslinger, M A; Hermanns, W

    1993-02-01

    A chronic gastritis caused by an infestation with O. tricuspis is described. The differential-diagnostic importance of this parasitosis in chronic maldigestive diseases is emphasized. Conventional coproscopic diagnostic procedures fail as the life cycle of the parasite is confined to the gastrum of the host. PMID:8457185

  5. Magnetic resonance imaging in agenesis of corpus callosum

    International Nuclear Information System (INIS)

    The recent use of computed tomography (CT) scan is providing an easy diagnoses of agenesis of corpus callosum which had been difficult to diagnose only by clinical signs and symptoms. Since, more neuropsychological studies on agenesis of corpus callosum are being done, clinical details of agenesis of corpus callosum are being clarified. We examined magnetic resonance imaging (MRI) on 3 patients who were suspected to have agenesis of corpus callosum by CT scan. And we studied the usefulness of MRI in agenesis of corpus callosum. By sagittal MRI, we could easily make a diagnosis on one case (Case 3) of hypoplasia of corpus callosum which could not been diagnosed by CT scan. On all of the cases, MRI showed the high intensity area of anterior commissure which had not been found by CT scan. Anomaly of cingurate gyrus was shown on all of the patients. MRI can show some important points in detail which CT scan can not reveal. The sagittal view especially is the most helpful for diagnosis of agenesis of corpus callosum. And we proposed that neuropsychological study on agenesis of corpus callosum should have MRI data. (J.P.N.)

  6. MR measurement of normal corpus callosum in children

    International Nuclear Information System (INIS)

    To measure the mean size of the various portions of the corpus callosum in normal Korean children, using MR imaging. Our subjects were 166 children (male : female=100 : 66) aged under 15 whose findings on MR imaging and neurologic examination were normal. Using midsagittal T1-weighted imaging, we measured the length of the brain and corpus callosum, the height of the latter, and the thickness of its genu body, transitional zone and splenium. The measurements were statistically analysed according to age and sex. Brain length and the size of the various portions of the corpus callosum tended to increase relatively rapidly during the first three years of life, but the rate of growth tended to decrease according to age. The mean lenght of the brain and corpus callosum and the mean thickness of the splenium of the corpus callosum did not differ according to sex. The mean thickness of the genu, body and transitional zone of the corpus callosum was greater in males than in females. The ratio of the length of the corpus callosum to the anteroposterior diameter of the brain was significantly greater in females than in males (alpha=0.05). Using MR imaging, we measured the mean sizes of the various portions of the corpus callosum in normal children;these values may provide a useful basis for determing changes occurring in its structure

  7. Corpus-Supported Academic Writing: How Can Technology Help?

    Science.gov (United States)

    Chitez, Madalina; Rapp, Christian; Kruse, Otto

    2015-01-01

    Phraseology has long been used in L2 teaching of academic writing, and corpus linguistics has played a major role in the compilation and assessment of academic phrases. However, there are only a few interactive academic writing tools in which corpus methodology is implemented in a real-time design to support formulation processes. In this paper,…

  8. On Automating and Standardising Corpus Callosum Analysis in Brain MRI

    DEFF Research Database (Denmark)

    Stegmann, Mikkel Bille; Skoglund, Karl

    2005-01-01

    Corpus callosum analysis is influenced by many factors. The effort in controlling these has previously been incomplete and scattered. This paper sketches a complete pipeline for automated corpus callosum analysis from magnetic resonance images, with focus on measurement standardisation. The prese...

  9. Use of "Google Scholar" in Corpus-Driven EAP Research

    Science.gov (United States)

    Brezina, Vaclav

    2012-01-01

    This primarily methodological article makes a proposition for linguistic exploration of textual resources available through the "Google Scholar" search engine. These resources ("Google Scholar virtual corpus") are significantly larger than any existing corpus of academic writing. "Google Scholar", however, was not designed for linguistic searches…

  10. Operative link for gastritis assessment vs operative link on intestinal metaplasia assessment

    Institute of Scientific and Technical Information of China (English)

    Massimo Rugge; Matteo Fassan; Marco Pizzi; Fabio Farinati; Giacomo Carlo Sturniolo; Mario Plebani; David Y Graham

    2011-01-01

    AIM: To compare the reliability of gastritis staging systems in ranking gastritis-associated cancer risk in a large series of consecutive patients.METHODS: Gastric mucosal atrophy is the precancerous condition in which intestinal-type gastric cancer (GC) most frequently develops. The operative link for gastritis assessment (OLGA) staging system ranks the GC risk according to both the topography and the severity of gastric atrophy (as assessed histologically on the basis of the Sydney protocol for gastric mucosal biopsy). Both cross-sectional and long-term follow-up trials have consistently associated OLGA stages Ⅲ-Ⅳ with a higher risk of GC. A recently-proposed modification of the OLGA staging system (OLGIM) basically incorporates the OLGA frame, but replaces the atrophy score with an assessment of intestinal metaplasia (IM) alone. A series of 4552 consecutive biopsy sets (2007-2009) was retrieved and reassessed according to both the OLGA and the OLGIM staging systems. A set of at least 5 biopsy samples was available for all the cases considered.RESULTS: In 4460 of 4552 cases (98.0%), both the high-risk stages (Ⅲ + Ⅳ) and the low-risk stages (0 +Ⅰ + Ⅱ) were assessed applying the OLGA and OLGIM criteria. Among the 243 OLGA high-risk stages, 14 (5.8%) were down-staged to a low risk using OLGIM. The 67 (1.5%) incidentally-found neoplastic lesions (intraepithelial or invasive) were consistently associated with high-risk stages, as assessed by both OLGA and OLGIM (P < 0.001 for both). Two of 34 intestinal-type GCs coexisting with a high-risk OLGA stage (stage Ⅲ) were associated with a low-risk OLGIM stage (stage Ⅱ).CONCLUSION: Gastritis staging systems (both OLGA and OLGIM) convey prognostically important information on the gastritis-associated cancer risk. Because of its clinical impact, the stage of gastritis should be included as a conclusive message in the gastritis histology report. Since it focuses on IM alone, OLGIM staging is less sensitive than

  11. Morphometric changes of the corpus callosum in congenital blindness

    DEFF Research Database (Denmark)

    Tomaiuolo, Francesco; Campana, Serena; Collins, D Louis;

    2014-01-01

    We examined the effects of visual deprivation at birth on the development of the corpus callosum in a large group of congenitally blind individuals. We acquired high-resolution T1-weighted MRI scans in 28 congenitally blind and 28 normal sighted subjects matched for age and gender. There was no...... overall group effect of visual deprivation on the total surface area of the corpus callosum. However, subdividing the corpus callosum into five subdivisions revealed significant regional changes in its three most posterior parts. Compared to the sighted controls, congenitally blind individuals showed a 12......% reduction in the splenium, and a 20% increase in the isthmus and the posterior part of the body. A shape analysis further revealed that the bending angle of the corpus callosum was more convex in congenitally blind compared to the sighted control subjects. The observed morphometric changes in the corpus...

  12. Myeloid HIF-1 is protective in Helicobacter pylori-mediated gastritis.

    Science.gov (United States)

    Matak, Pavle; Heinis, Mylène; Mathieu, Jacques R R; Corriden, Ross; Cuvellier, Sylvain; Delga, Stéphanie; Mounier, Rémi; Rouquette, Alexandre; Raymond, Josette; Lamarque, Dominique; Emile, Jean-François; Nizet, Victor; Touati, Eliette; Peyssonnaux, Carole

    2015-04-01

    Helicobacter pylori infection triggers chronic inflammation of the gastric mucosa that may progress to gastric cancer. The hypoxia-inducible factors (HIFs) are the central mediators of cellular adaptation to low oxygen levels (hypoxia), but they have emerged recently as major transcriptional regulators of immunity and inflammation. No studies have investigated whether H. pylori affects HIF signaling in immune cells and a potential role for HIF in H. pylori-mediated gastritis. HIF-1 and HIF-2 expression was examined in human H. pylori-positive gastritis biopsies. Subsequent experiments were performed in naive and polarized bone marrow-derived macrophages from wild-type (WT) and myeloid HIF-1α-null mice (HIF-1(Δmyel)). WT and HIF-1(Δmyel) mice were inoculated with H. pylori by oral gavage and sacrificed 6 mo postinfection. HIF-1 was specifically expressed in macrophages of human H. pylori-positive gastritis biopsies. Macrophage HIF-1 strongly contributed to the induction of proinflammatory genes (IL-6, IL-1β) and inducible NO synthase in response to H. pylori. HIF-2 expression and markers of M2 macrophage differentiation were decreased in response to H. pylori. HIF-1(Δmyel) mice inoculated with H. pylori for 6 mo presented with a similar bacterial colonization than WT mice but, surprisingly, a global increase of inflammation, leading to a worsening of the gastritis, measured by an increased epithelial cell proliferation. In conclusion, myeloid HIF-1 is protective in H. pylori-mediated gastritis, pointing to the complex counterbalancing roles of innate immune and inflammatory phenotypes in driving this pathology. PMID:25710915

  13. Immunoexpression of CD95 in chronic gastritis and gastric mucosa-associated lymphomas

    Directory of Open Access Journals (Sweden)

    Vassallo J.

    2004-01-01

    Full Text Available CD95 (Fas/APO-1-mediated apoptosis plays an important role in immunological regulation and is related to the pathogenesis of autoimmune diseases. Immunoexpression of CD95 has been reported to frequently occur in low grade non-Hodgkin lymphomas, especially of post-germinal center histogenesis, among which those originating in mucosa-associated lymphoid tissue (MALT lymphomas. However, there is no report comparing in situ immunoexpression of this marker in lymphomas and the hyperplastic lymphoid reaction (chronic gastritis related to Helicobacter pylori infection. The purpose of the present research was to compare the intensity of lymphoid CD95 immunoexpression in 15 cases of H. pylori-related chronic gastritis and 15 gastric MALT lymphomas. CD95 (anti-CD95 was detected by an immunoperoxidase technique in paraffin sections using the catalyzed amplification system. Graduation of reaction intensity (percentage of CD95-positive cells was semiquantitative, from 1+ to 4+. Nine cases of chronic gastritis were 4+, five 2+ and one 1+. Three lymphomas were 4+, three 3+, four 2+, four 1+, and one was negative. Although 14 of 15 lymphomas were positive for CD95, the intensity of the reaction was significantly weaker compared to that obtained with gastric tissue for patients with gastritis (P = 0.03. The difference in CD95 immunoexpression does not seem to be useful as an isolated criterion in the differential diagnosis between chronic gastritis and MALT lymphomas since there was overlapping of immunostaining patterns. However, it suggests the possibility of a pathogenetic role of this apoptosis-regulating protein in MALT lymphomas.

  14. Concordancia endoscópico-histológica de la gastritis crónica en Cali

    OpenAIRE

    Gustavo Mariño; Eduardo Lima; Fernado Tuffi García; Carlos Cuello; Harold Cuello; Alberto Alzate

    2009-01-01

    Se realizó un estudio prospectivo con el fin de evaluar la concordancia entre signos endoscópicos y diagnóstico histológico en 216 pacientes con gastritis y metaplasia intestinal. Se estableció un registro codificado de los signos sugestivos de gastritis, que se correlacionaron con los diagnósticos histológicos de las biopsias gástricas. Se seleccionaron aquellas asociaciones que tuvieran una correlación mayor que la esperada por azar. Estas fueron: gastritis atrófica y aumento de visibilidad...

  15. Insights from a Learner Corpus as Opposed to a Native Corpus about Cohesive Devices in an Academic Writing Context

    Science.gov (United States)

    Ersanli, Ceylan Yangin

    2015-01-01

    This study reports on the insights from an EFL learner corpora (a total of 151 essays and 49,690 words) generated from essays collected over the years in a Turkish state university from freshmen students enrolling in the Advanced Writing course. The comparison of cohesive devices in the non-native corpus (NNC) with those in a native corpus (NC)…

  16. Two directions of change in one corpus

    DEFF Research Database (Denmark)

    Jensen, Marie Møller

    2015-01-01

    Cheshire et al. (2005) argue that different levels of language do not necessarily follow the same patterns of change over time. In an attempt to test this prediction, this article reports on a comparison between two quantitative corpus studies of Tyneside English which are partly based on the same...... data. The first study was carried out by Watt and investigated levelling in the phonological variables in the FACE and GOAT lexical set (Watt 2002) based on data collected in 1994. Watt found that speakers were abandoning broad local vernacular variants in favour of more regional or generally Northern...... forms. The second study was a study of seven morphosyntactic variables based on data collected in the 1960s, 1994 and 2007-2009. This study found that the variables under investigation were either stable over time or used more frequently in the most recent data. Thus, the comparison of the two studies...

  17. The constitution of the corpus of research

    Directory of Open Access Journals (Sweden)

    Reinoldo Marquezan

    2009-04-01

    Full Text Available This study will reflect on the construction of an object of research: the discursive corpus of analysis from the file constituted by the Special Education law. It is anchored in the theoretical device of the french discourse analysis inaugurated by Michel Pêcheux. The construction of a research object requires the consideration of some factors: object, question and research problem. It requires a broad preliminary exploration of the subject to insert the research in a theoretical chart setting out the fundamental concepts that the researcher mobilize. It is necessary to do some cuttings that imply in discourses’ reading, description and interpretation. Based on this interpretation, it produces new senses, because it promotes new information about the formulated questions.

  18. Translations of "donc" in a literary corpus

    OpenAIRE

    Gemma Delgar Farrés

    2013-01-01

    [FR] L'objectif de cette étude est l'analyse des traductions en espagnol de « donc » à partir des propriétés sémantico-pragmatiques et textuelles de ce connecteur dans un corpus littéraire et, en particulier, dans deux textes de genres différents: le théâtre et le roman. Il est évident, en conséquence, que le choix du discours littéraire, et de ces deux genres, va conditionner cette analyse dès le début et ce fait même justifie notre choix. Ces mots de Dominique Maingueneau (1986 : 135) vienn...

  19. Tabularité : des textes aux corpus

    OpenAIRE

    Florea, Marie-Laure

    2011-01-01

    Cet article propose d’envisager un type particulier de texte, le texte tabulaire, qui s’oppose au texte linéaire, du double point de vue du texte et du corpus. Le texte tabulaire est un texte composé de plusieurs modules, ayant chacun une autonomie relative mais étant interdépendants les uns des autres, regroupés sur un espace matériel borné. L’objectif est double : il s’agit d’une part de décrire, dans une perspective croisée d’analyse du discours et de linguistique textuelle, le fonctionnem...

  20. Metaphor and Corpus Linguistics Metáfora e linguística de corpus

    Directory of Open Access Journals (Sweden)

    Tony Berber Sardinha

    2011-01-01

    Full Text Available In this paper, I look at four different aspects of metaphor research from a corpus linguistic perspective, namely: (1 the lexicogrammar of metaphors, which refers to the patterning of linguistic metaphor revealed by corpus analysis; (2 metaphor probabilities, which is a facet of metaphor that emerges from frequency-based studies of metaphor; (3 dimensions of metaphor variation, or the search for systematic parameters of variation in metaphor use across different registers; and (4 automated metaphor retrieval, which relates to the development of software to help identify metaphors in corpora. I argue that these four aspects are interrelated, and that advances in one of them can drive changes in the others.Neste artigo discuto quarto aspectos da pesquisa sobre metáfora do ponto de vista da linguística de corpus: (1 a lexicogramática das metáforas, que se refere aos padrões da metáfora linguística revelados pela análise de corpus; (2 probabilidades metafóricas, que é uma faceta da metáfora que emerge a partir dos estudos relacionados à freqüência de metáforas; (3 dimensões da variação de metáforas, ou a busca por parâmetros sistemáticos de variação de uso de metáfora em diferentes gêneros; e (4 captura automática de metáfora, que está relacionada ao desenvolvimento de softwares que auxiliam na identificação de metáforas em corpora. I defendo que esses quatro aspectos são interrelacionados, e que progressos em um deles podem acarretar mudanças nos outros.

  1. From Business Corpus to Business Lexicon*

    Directory of Open Access Journals (Sweden)

    Li Lan

    2011-10-01

    Full Text Available

    Abstract: Language corpora are now indispensable to dictionary compilation. They help broaden the role of the dictionary from standardizing the vocabulary to recording a language. The trilingual corpus generated by the Hong Kong Polytechnic University gives a record of business languages used in Hong Kong. It differs from other corpora in that (1 it includes English, Chinese and Japanese; (2 it shows local characteristics; and (3 it focuses on a specific area (financial services, including banking, accounting, auditing, insurance and investment. The paper discusses various issues of setting up a tricorpus, and how to make full use of the data to generate a trilingual lexicon.

    Keywords: MULTILINGUAL, SPECIAL PURPOSE, CORPUS, LEXICON

    Opsomming: Van sakekorpus tot sakeleksikon. Taalkorpora is tans onontbeerlik virdie samestelling van woordeboeke. Hulle help om die rol van die woordeboek uit te brei vanaf diestandaardisering van die woordeskat tot die optekening van ‘n taal. Die drietalige korpus wat deurdie Hongkongse Politegniese Universiteit ontwikkel is, verskaf ‘n opgawe van die saketale wat inHongkong gebruik word. Dit verskil van ander korpora deurdat (1 dit Engels, Chinees and Japaneesinsluit; (2 dit plaaslike eienskappe vertoon; en (3 dit op 'n spesifieke gebied (finansiële dienste,insluitende bankwese, rekeningkunde, ouditering, versekering en belegging fokus. Die artikelbespreek verskillende aspekte van die totstandbrenging van 'n drietalige korpus, en hoe om vollegebruik te maak van die data om 'n drietalige leksikon te genereer.

    Sleutelwoorde: MEERTALIG, SPESIALE DOEL, KORPUS, LEKSIKON

  2. Osteogenic potency of human bone marrow mesenchymal stem cells from femoral atrophic non-union fracture site

    Directory of Open Access Journals (Sweden)

    Ismail Hadisoebroto Dilogo

    2014-06-01

    Full Text Available Objective: Mesenchymal stem cells (MSCs exist in the site of atrophic non-union fracture. The aim of this study was to evaluate the osteogenic potency of MSCs in order to have a better understanding of the unclear pathophysiology of atrophic non-union fracture Methods: This is an in vitro experimental study. Sample was obtained from the non-union site of a patient with a 6-years-history of atrophic non-union fracture of right femur. The MSCs was isolated from the fracture site and was cultured in the growth medium. Confirmation of the MSCs was performed and then osteogenic differentiation was performed in mono-layered MSC grown in both home-made and commercial osteogenic media. To evaluate the osteogenic differentiation, we performed Alizarin red staining and colorimetric assay for alkaline phosphatase (ALP. Results: From Alizarin red staining, most cells in the osteoblast medium were stained red by the staining. The result of colorimetric assessment of ALP shows that peak concentration was reached after 4 minutes in osteogenic group and control group. Conclusion: The presence of ALP activity and positive Alizarin red staining in our study showed that MSCs stem cells obtained from site of atrophic non-union is capable to be differentiated into osteogenic cells. . J Clin Exp Invest 2014; 5 (2: 159-163

  3. Possibility of non-invasive diagnosis of gastric mucosal precancerous changes

    Institute of Scientific and Technical Information of China (English)

    Victor D. Pasechnikov; Sergey Z. Chukov; Sergey M. Kotelevets; Alexander N. Mostovov; Varvara P. Mernova; Maria B. Polyakova

    2004-01-01

    AIM: To assess the possibility of non-invasive screening of atrophic chronic gastritis for preventing further development of gastric cancer.METHODS: One hundred and seventy-eight consecutive Helicobacter pylori ( H pylori)-positive dyspeptic patients after detection of serum levels of pepsinogen-1 (PG-1) and gastrin-17 (G-17) by enzyme immunoassay were proposed for endoscopy and histology. The serologic and morphologic results were compared with estimating the sensitivity,specificity and prognostic values of the tests.RESULTS: There was statistically significant reverse dependence between the grade of stomach mucosal antral or corpus atrophy and the proper decreasing of serum G17or PG1 levels. The serologic method was quite sensitive in the diagnosis of non-atrophic and severe antral and corpus gastritis. Also, it was characterized by the high positive and negative prognostic values.CONCLUSION: Detection of serum G-17 and PG1 levels can be offered as the screening tool for atrophic gastritis. The positive serologic results require further chromoendoscopy with mucosal biopsy, for revealing probable progressing of atrophic process with development of intestinal metaplasia,dysplasia or gastric cancer.

  4. Restoration of an atrophic eye socket with custom made eye prosthesis, utilizing digital photography

    Directory of Open Access Journals (Sweden)

    Gaurav P Jayaswal

    2011-01-01

    Full Text Available Ocular defects may cause several ocular and orbital disorders, which require surgical intervention. These defects are psychologically disturbing for the patients, and therefore, they require immediate management and rehabilitation by a team of specialist. Ocular prosthesis may be either readymade (stock or custom made. Fabrication of a custom ocular prosthesis allows for a range of variations during construction. The iris can also be custom made by ocular painting or by digital photography. The optimum cosmetic and functional results of a custom-made prosthesis enhance the patient′s rehabilitation to a normal life style. This paper elaborates the technique for fabrication of a custom-made ocular prosthesis for an atrophic eye socket utilizing digital photography.

  5. Corpus Linguistics and the Design of a Response Message

    Science.gov (United States)

    Atwell, E.

    2002-01-01

    Most research related to SETI, the Search for Extra-Terrestrial Intelligence, is focussed on techniques for detection of possible incoming signals from extra-terrestrial intelligent sources (e.g. Turnbull et al. 1999), and algorithms for analysis of these signals to identify intelligent language-like characteristics (e.g. Elliott and Atwell 1999, 2000). However, another issue for research and debate is the nature of our response, should a signal arrive and be detected. The design of potentially the most significant communicative act in history should not be decided solely by astrophysicists; the Corpus Linguistics research community has a contribution to make to what is essentially a Corpus design and implementation project. (Vakoch 1998) advocated that the message constructed to transmit to extraterrestrials should include a broad, representative collection of perspectives rather than a single viewpoint or genre; this should strike a chord with Corpus Linguists for whom a central principle is that a corpus must be "balanced" to be representative (Meyer 2001). One idea favoured by SETI researchers is to transmit an encyclopaedia summarising human knowledge, such as the Encyclopaedia Britannica, to give ET communicators an overview and "training set" key to analysis of subsequent messages. Furthermore, this should be sent in several versions in parallel: the text; page-images, to include illustrations left out of the text-file and perhaps some sort of abstract linguistic representation of the text, using a functional or logic language (Ollongren 1999, Freudenthal 1960). The idea of "enriching" the message corpus with annotations at several levels should also strike a chord with Corpus Linguists who have long known that Natural language exhibits highly complex multi-layering sequencing, structural and functional patterns, as difficult to model as sequences and structures found in more traditional physical and biological sciences. Some corpora have been annotated with

  6. Local inhibition of angiogenesis results in an atrophic non-union in a rat osteotomy model

    Directory of Open Access Journals (Sweden)

    M Fassbender

    2011-07-01

    Full Text Available Long bone and in particular tibia fractures frequently fail to heal. A disturbed revascularisation is supposed to be a major cause for impaired bone healing or the development of non-unions. We aim to establish an animal model, which reliably mimics the clinical situation. Human microvascular endothelial cells (HMEC-1 and primary human osteoblast like cells (POBs were cultured with different angiogenesis-inhibitors (Fumagillin, SU5416, Artesunate and 3,5,4’-Trimethoxystilbene released out of poly(D,L-Lactide (PDLLA coated k-wires and cell activity was determined. Discs containing PDLLA or PDLLA + Fumagillin/Artesunate were placed at the chorionallantoic membrane of hen eggs and the effect on vessel formation and egg vitality was observed. Tibia osteotomy was performed in rats and stabilised with K-wires coated with PDLLA + Fumagillin or with PDLLA only (control group. The healing was compared at different time points to the PDLLA control. Fumagillin and Artesunate inhibited the activity of HMEC-1 with minor effect on POBs. Artesunate caused embryonic death, whereas Fumagillin had no effects on egg vitality, but reduced the blood vessels. In the animal study all rats showed an impaired healing with reduced biomechanical stability. The Fumagillin treated tibiae had a significantly decreased callus size at day 42 and 84, less blood vessels in the early callus, a reduced histological callus size at day 10, 28 and 84, as well as an altered callus composition. This study presents a less vascularised, atrophic, tibia non-union and can be used in further investigations to analyse the pathology of atrophic non-union and to test new interventions.

  7. In vivo 31P-NMR studies on the energy metabolism of atrophic muscles in rate

    International Nuclear Information System (INIS)

    Using P-31 NMR spectra, energy metabolism in the rat calf muscle was examined. The body weight in the atrophy and control groups did not differ significantly. Both the wet weight and dry weight of the calf muscle were significantly lower in the atrophy group than the control group. The muscle weight relative to the body weight was significantly lower in the atrophy group as well than the control group. There was no significant difference in the P-31 NMR spectral pattern before tourniquet ischemia between the atrophy and control groups. Rapid decrease in phosphocreatine (PCr) and rapid increase in inorganic phosphate (Pi) were observed in both groups immediately after application of the tourniquet; however, the rates of these changes were slightly greater and the PCr/Pi ratio in the peak values was significantly smaller in the atrophy group than the control group. The pH value before the ischemia was 7.15 ± 0.02 for the control group and 7.16 ± 0.02 for the atrophy group, with no significant difference between the groups. During ischemia, the pH value decreased progressively in the two groups; however, it became significantly decreased in the atrophy group from 10 to 60 min after application of tourniquet. The decrease in pH became gradual 60 min later. Since the decrease in pH was more rapid in the atrophic muscle than the intact muscle, this buffering capacity seems to be reduced in the atrophic muscle. (N.K.)

  8. Mesenchymal stem cell implantation in atrophic nonunion of the long bones

    Science.gov (United States)

    Phedy, P.; Kholinne, E.; Djaja, Y. P.; Kusnadi, Y.; Merlina, M.; Yulisa, N. D.

    2016-01-01

    Objectives To explore the therapeutic potential of combining bone marrow-derived mesenchymal stem cells (BM-MSCs) and hydroxyapatite (HA) granules to treat nonunion of the long bone. Methods Ten patients with an atrophic nonunion of a long bone fracture were selectively divided into two groups. Five subjects in the treatment group were treated with the combination of 15 million autologous BM-MSCs, 5g/cm3 (HA) granules and internal fixation. Control subjects were treated with iliac crest autograft, 5g/cm3 HA granules and internal fixation. The outcomes measured were post-operative pain (visual analogue scale), level of functionality (LEFS and DASH), and radiograph assessment. Results Post-operative pain evaluation showed no significant differences between the two groups. The treatment group demonstrated faster initial radiographic and functional improvements. Statistically significant differences in functional scores were present during the first (p = 0.002), second (p = 0.005) and third (p = 0.01) month. Both groups achieved similar outcomes by the end of one-year follow-up. No immunologic or neoplastic side effects were reported. Conclusions All cases of nonunion of a long bone presented in this study were successfully treated using autologous BM-MSCs. The combination of autologous BM-MSCs and HA granules is a safe method for treating nonunion. Patients treated with BM-MSCs had faster initial radiographic and functional improvements. By the end of 12 months, both groups had similar outcomes. Cite this article: H.D. Ismail, P. Phedy, E. Kholinne, Y. P. Djaja, Y. Kusnadi, M. Merlina, N. D. Yulisa. Mesenchymal stem cell implantation in atrophic nonunion of the long bones: A translational study. Bone Joint Res 2016;5:287–293. DOI: 10.1302/2046-3758.57.2000587. PMID:27412657

  9. The tolerance of feline corpus and cauda spermatozoa to cryostress.

    Science.gov (United States)

    Kunkitti, Panisara; Bergqvist, Ann-Sofi; Sjunnesson, Ylva; Johannisson, Anders; Axnér, Eva

    2016-02-01

    Epididymal sperm preservation can be used to avoid the total loss of genetic material in threatened species. Spermatozoa from the corpus, as from the cauda, are motile and can undergo capacitation. Thus, they can potentially be preserved for assisted reproductive technologies. However, cryopreservation of spermatozoa has a direct detrimental effect on sperm quality. The aim of this study was to compare the chromatin stability and the survival rate of spermatozoa from the corpus and cauda epididymis after cryopreservation. Epididymal spermatozoa were collected and cryopreserved from the corpus and cauda of 12 domestic cats. Sperm motility, progressive motility, membrane integrity, acrosome integrity, and DNA integrity were evaluated before and after freezing thawing. The average total number of spermatozoa collected from the corpus was lower (10.2 × 10(6) ± 7.4) than that from the cauda epididymis (24.9 × 10(6) ± 14.4; P = 0.005). The percentage of spermatozoa with intact DNA did not differ significantly whether it was collected from the corpus or cauda regions and did not decrease after freezing thawing in either region. However, motility of spermatozoa from both regions was affected by the freezing thawing process with a significant decline in motility after thaw compared with fresh spermatozoa. A significant difference in the percentage of motile sperm between the corpus and cauda was observed after the freezing thawing process (P < 0.001). Although sperm motility was lower in postthaw spermatozoa from the corpus epididymidis than from the cauda, the rate of the reduction did not differ between regions. This study indicates that the cryopreservation process does not have a negative effect on chromatin stability of feline epididymal spermatozoa. Spermatozoa from the corpus region have a similar freezability as spermatozoa from the cauda region. Therefore, preservation of spermatozoa from the corpus and the cauda epididymidis might be of value in preserving

  10. Helicobacter pylori lipopolysaccharide: Biological activities in vitro and in vivo, pathological correlation to human chronic gastritis and peptic ulcer

    OpenAIRE

    Luo, Yi-Hui; Yan, Jie; Mao, Ya-Fei

    2004-01-01

    AIM: To determine the biological activity of Helicobacter pylori (H pylori) lipopolysaccharide (H-LPS) and understand pathological correlation between H-LPS and human chronic gastritis and peptic ulcer.

  11. Postprandial fullness correlates with rapid inflow of gastric content into duodenum but not with chronic gastritis

    Directory of Open Access Journals (Sweden)

    Yamamichi Nobutake

    2011-12-01

    Full Text Available Abstract Background The aim of this study is evaluating the correlation of postprandial fullness with chronic gastritis or rapid inflow of gastric content into duodenum, based on double-contrast barium X-ray imaging. Methods 253 healthy subjects who underwent upper gastrointestinal barium X-ray examination were analyzed. Chronic gastritis was judged from mucosal atrophy and hypertrophic thickened folds on barium X-ray images. For the gastric excretion, the tips of barium flow on the single-contrast frontal barium X-ray images of the stomach were classified into four categories; V type (all the barium remained in the stomach, V-H type (some barium had flowed into the duodenum but the tip of barium remained in the proximal half of the duodenal bulb, H-V type (some barium had flowed into the duodenum and the tip of barium was in the distal half of duodenal the bulb, but no barium was observed in the descending part of the duodenum, and H type (some barium had flowed into the descending part of the duodenum. The chi-square test and Cochran-Mantel-Haenzel test were used for evaluation. Results Chronic gastritis was observed in 72 subjects, among which 21 subjects (29.2% presented with postprandial fullness. For the remaining 181 subjects without chronic gastritis, 53 subjects (29.3% complained of postprandial fullness. There is no significant correlation between chronic gastritis and postprandial fullness (p = 0.973. For the rapid flow of gastric content into duodenum, all the 253 subjects comprised 136 subjects with V type (in the stomach, 40 subjects with V-H type (in the proximal half of the duodenal bulb, 21 subjects with H-V type (in the distal half of the duodenal bulb, and 56 subjects with H type (in the descending part of the duodenum. Postprandial fullness was present in 30 subjects with V type (22.1%, 9 subjects with V-H type (22.5%, 8 subjects with H-V type (38.1%, and 27 subjects with H type (48.2%. There is a distinct correlation between

  12. A comparative study of vaginal estrogen cream and sustained-release estradiol vaginal tablet (Vagifem in the treatment of atrophic vaginitis in Isfahan, Iran in 2010-2012

    Directory of Open Access Journals (Sweden)

    Pardis Hosseinzadeh

    2015-01-01

    Full Text Available Background: Atrophic vaginitis is a disease, which affects up to 50% of postmenopausal women. This study compared the effectiveness and user-friendliness of Vagifem (an estradiol vaginal tablet and vaginal estrogen cream in the treatment of atrophic vaginitis. Materials and Methods: One hundred and sixty postmenopausal women with symptoms of atrophic vaginitis were randomly divided into two groups of treatment with Vagifem or with vaginal estrogen cream for 12 weeks. Patients used the medication daily for the first 2 weeks of the study, and twice weekly. Severity of vaginal atrophy and four main symptoms of atrophic vaginitis including dysuria, dyspareunia, vaginal itching, and dryness were evaluated and compared before and after treatment. In addition, patients were asked regarding user-friendliness and hygienic issues of medications. Results: Both vaginal estrogen cream and Vagifem significantly improved symptoms of atrophic vaginitis but in terms of effectiveness for the treatment symptoms of atrophic vaginitis, there was no significant difference between the two medications. Vagifem compared to estrogen cream resulted in significantly lower rate of hygienic problems (0% versus 23%, P < 0.001, and was reported by the patients as a significantly easier method of treatment (90% versus 55%, P < 0.0001. Conclusion: This investigation showed that Vagifem is an appropriate medication for the treatment of atrophic vaginitis, which is as effective as vaginal estrogen creams and is more user-friendly.

  13. Cavernous Angioma of the Corpus Callosum Presenting with Acute Psychosis

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    Giacomo Pavesi

    2014-01-01

    Full Text Available Psychiatric symptoms may occasionally be related to anatomic alterations of brain structures. Particularly, corpus callosum lesions seem to play a role in the change of patients’ behavior. We present a case of a sudden psychotic attack presumably due to a hemorrhagic cavernous angioma of the corpus callosum, which was surgically removed with complete resolution of symptoms. Although a developmental defect like agenesis or lipoma is present in the majority of these cases, a growing lesion of the corpus callosum can rarely be the primary cause. Since it is potentially possible to cure these patients, clinicians should be aware of this association.

  14. Influence of Helicobacter pylori Colonization on Histological Grading of Chronic Gastritis in Korean Patients with Peptic Ulcer

    OpenAIRE

    Park, Joongwon; Kim, Mi Kyung; Park, Sill Moo

    1995-01-01

    Objectives: We conducted an analysis of correlation between histological grading of chronic gastritis and the presence of H. pylori infection to investigate if H. pylori influences histological severity of chronic gastritis in Korean patients with peptic ulcers. Methods: Gastroscopic antral biopsy specimens and peripheral venous blood were taken from 80 patients with gastric or duodenal ulcers. H. pylori was identified microscopically in sections with Giemsa staining and quantitative grading ...

  15. Hubungan kadar IL-8 dan IL-10 pada pasien Gastritis H.Pylori dan Non H.Pylori

    OpenAIRE

    Ginting, Ananda Wibawanta

    2016-01-01

    Background: Helicobacter pylori (H.pylori) is the commonest cause of chronic active gastritis all over the world which is around 80% in addition to other causes such as autoimmune diseases, drugs, idiopathic and others. In gastritis, there are acute and chronic inflammatory response occurs activation cytokines-cytokines that cause inflammation of the mucosa where the levels of IL-6, IL-8, TNF-alpha mucosa increased in dyspepsia patients infected with H. pylori. On the one hand ...

  16. Complete Genome Sequence of Helicobacter pylori Strain 7C Isolated from a Mexican Patient with Chronic Gastritis.

    Science.gov (United States)

    Mucito-Varela, Eduardo; Castillo-Rojas, Gonzalo; Cevallos, Miguel A; Lozano, Luis; Merino, Enrique; López-Leal, Gamaliel; López-Vidal, Yolanda

    2016-01-01

    Helicobacter pylori-induced gastritis is a risk factor for developing gastric pathologies. Here, we report the complete genome sequence of a multidrug-resistant H. pylori strain isolated from a chronic gastritis patient in Mexico City, Mexico. Nonvirulent VacA and cag-pathogenicity island (PAI) genotypes were found, but the presence of a potential mobilizable plasmid carrying an IS605 element is of outstanding interest. PMID:26744372

  17. Complete Genome Sequence of Helicobacter pylori Strain 7C Isolated from a Mexican Patient with Chronic Gastritis

    OpenAIRE

    Mucito-Varela, Eduardo; Castillo-Rojas, Gonzalo; Cevallos, Miguel A.; Lozano, Luis; Merino, Enrique; López-Leal, Gamaliel; López-Vidal, Yolanda

    2016-01-01

    Helicobacter pylori-induced gastritis is a risk factor for developing gastric pathologies. Here, we report the complete genome sequence of a multidrug-resistant H. pylori strain isolated from a chronic gastritis patient in Mexico City, Mexico. Nonvirulent VacA and cag-pathogenicity island (PAI) genotypes were found, but the presence of a potential mobilizable plasmid carrying an IS605 element is of outstanding interest.

  18. A comparative study of single use and combined use of lansoprazole, deanxit in treating erosive gastritis complicated with negative emotions

    Institute of Scientific and Technical Information of China (English)

    龚家顺

    2014-01-01

    Objective To study the effect of single use and combined use of lansoprazole,deanxit in treating erosive gastritis complicated with negative emotions.Methods Erosive gastritis patients complicated with negative emotions in our hospital from January,2011—December,2012were enrolled and randomly divided into observation group and control group.Observation group was given deanxit 1 tablet every time,2 times every day and lansoprazole 15 mg every time,2 times every day;control

  19. Histopathologic Characterization of Acute Gastritis and Duodenitis Induced by Inoculation of Escherichia coli O157 in Mice

    OpenAIRE

    Horii, Toshinobu; KOBAYASHI, Miya

    2011-01-01

    Objective: To examine the effect of intragastric inoculation of an Escherichia coli O157 strain, which does not have such pathogenic factors as the stx, eae and EHEC-hlyA genes, on the induction of acute gastritis and duodenitis in BALB/c mice. Design: Time-dependent histopathologic changes were characterized in stomach and duodenum mucoepithelium by light and transmission electron microscopy. Results: The acute gastritis was characterized by inflammation and polymorphonuclear leukocyte infil...

  20. Spontaneous Autoimmune Gastritis in C3H/He Mice : A New Mouse Model for Gastric Autoimmunity

    OpenAIRE

    Alderuccio, Frank; Toh, Ban Hock

    1998-01-01

    Autoimmune gastritis is the underlying pathological lesion of pernicious anemia in humans. The lesion is characterized by a chronic inflammatory infiltrate in the gastric mucosa with loss of parietal and zymogenic cells. It is associated with circulating autoantibodies to the gastric H/K-ATPase, the enzyme responsible for acidification of gastric juice. Experimental models of autoimmune gastritis have previously been produced in mice after a variety of manipulations, including thymectomy. Her...

  1. The prevalence of lymphoid follicles in Helicobacter pylori associated gastritis in patients with ulcers and non-ulcer dyspepsia.

    OpenAIRE

    Zaitoun, A M

    1995-01-01

    AIMS--To determine the prevalence of lymphoid follicles in Helicobacter pylori positive and negative gastritis in antral and body type gastric mucosa in patients with non-ulcer dyspepsia (NUD), duodenal ulcer, or gastric ulcer; to correlate follicle presence with patient age; to evaluate the correlation between the prevalence of lymphoid follicles and active and inactive gastritis and its severity; and to assess the positive predictive value of lymphoid follicle prevalence with respect to H p...

  2. FTA Corpus: a parallel corpus of English and Spanish Free Trade Agreements for the study of specialized collocations

    Directory of Open Access Journals (Sweden)

    Pedro Patiño García

    2013-04-01

    Full Text Available This paper describes the Corpus of Free Trade Agreements (henceforth FTA, a specialized parallel corpus in English and Spanish from Europe and America and a smaller subcorpus in English-Norwegian and Spanish-Norwegian that was prepared and then aligned with Translation Corpus Aligner 2 (Hofland & Johansson, 1998. The data was taken from Free Trade Agreements. These agreements are specialized texts officially signed and ratified by several countries and blocks of countries in the last twenty years. Thus, FTAs are a rich repository for terminology and phraseology that is used in different fields of business activity throughout the world. The corpus contains around 1.37 million words in the English section and 1.48 million words in its Spanish counterpart, plus 60,000 words each in the Spanish-Norwegian and English-Norwegian subcorpus. The corpus is being used primarily to study the terms and specialized collocations that include these terms in this kind of specialized texts.Keywords: specialized collocation, specialized parallel corpus, corpus linguistics, Free Trade Agreement

  3. Concordancia endoscópico-histológica de la gastritis crónica en Cali

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    Gustavo Mariño

    2009-10-01

    Full Text Available Se realizó un estudio prospectivo con el fin de evaluar la concordancia entre signos endoscópicos y diagnóstico histológico en 216 pacientes con gastritis y metaplasia intestinal. Se estableció un registro codificado de los signos sugestivos de gastritis, que se correlacionaron con los diagnósticos histológicos de las biopsias gástricas. Se seleccionaron aquellas asociaciones que tuvieran una correlación mayor que la esperada por azar. Estas fueron: gastritis atrófica y aumento de visibilidad de vasos en antro, Kappa 0.208 (0.041-0.376; gastritis atrófica y aumento de visibilidad de vasos en cuerpo gástrico, Kappa 0.195 (0.002-0.388; gastritis atrófica y superficie en empedrado en antro, Kappa 0.213 (0.044-0.381; inflamación aguda y pliegues engrosados en antro, Kappa 0.094 (0.018-0.16. Hubo una concordancia pobre entre la mayoría de los signos endoscópicos y los diagnósticos histológicos. El diagnóstico definitivo de la gastritis sólo se debe hacer con base en los estudios histológicos de las biopsias.

  4. Fatal Clostridium perfringens sepsis due to emphysematous gastritis and literature review.

    Science.gov (United States)

    Sarvari, Karoly Peter; Vasas, Bela; Kiss, Ildiko; Lazar, Andrea; Horvath, Istvan; Simon, Marianna; Peto, Zoltan; Urban, Edit

    2016-08-01

    A 76-year-old female patient was admitted to the Level I Emergency Department of University of Szeged with severe abdominal pain and vomiting. The clinical assessment with laboratory tests and radiological investigations confirmed severe sepsis associated with intravascular hemolysis and multiorgan failure and acute pancreatitis. On the abdominal CT, besides of other abnormalities, the presence of gas bubbles in the stomach, small intestines and liver were seen. The gastric alterations pointed to emphysematous gastritis. Despite of the medical treatment, the patient's condition quickly deteriorated and eight hours after admission the patient died. The autopsy evaluation revealed systemic infection of abdominal origin caused by gas-producing Gram-positive bacteria, and the post-mortem microbiological cultures confirmed the presence of Cloctridium perfringens in many abdominal organs. Emphysematous gastritis seemed to be the primary infectious focus. PMID:27036998

  5. A 16-year-old boy with emphysematous gastritis and oesophageal candidiasis.

    Science.gov (United States)

    Yusef, Daniel; Waran, Ariane; Vamvakiti, Ekaterini

    2014-01-01

    Emphysematous gastritis is a rare and frequently fatal condition caused by invasion of gas-forming bacteria into the gastric wall. There have only been a handful of reported cases in the paediatric population, and none of these have evidence of candidal infection or mucormycosis. Patients typically present with abdominal pain, vomiting, malaena and haematemesis. Risk factors for emphysematous gastritis are those that interfere with the natural barriers to infection in the stomach. Diagnosis is made on the basis of typical appearances on abdominal CT. Treatment is generally conservative with surgery reserved for failed medical management or later complications. Antimicrobial cover should be broad with a low threshold for antifungals. It is important to look for predisposing factors for this condition, perhaps including an assessment of the patient's immunocompetency. We present a 16-year-old boy with global developmental delay who presented with this condition associated with candidal infection. PMID:25213783

  6. A case of radiation hemorrhagic gastritis successfully treated by endoscopic argon plasma coagulation

    International Nuclear Information System (INIS)

    A 72-year-old woman underwent irradiation of 46 Grey in total dose, for lumbago of the advanced pancreatic cancer in August 2000. She was admitted to our hospital due to severe anemia in February 2001 with occasionally positive fecal occult blood. Endoscopy revealed erosive gastric mucosa diffuse in the lower body of the stomach, which resulted from radiation. We applied argon plasma coagulation (APC) in March 2001 and succeeded in hemostasis of the widely spreading radiation hemorrhagic gastritis. The progress of the severe anemia improved without cicatricial stenosis. As the coagulation of the APC is limited in the surface mucosa, APC is an easy and effective treatment for radiation hemorrhagic gastritis. (author)

  7. The relationship between Helicobacter pylori-associated gastritis or ulcer disease and gastric emptying

    International Nuclear Information System (INIS)

    Forty-five patients with Helicobacter pylori (HP)-associated gastritis or ulcer disease were included in this study. Radionuclide-labelled solid meals were used to calculate gastric emptying times (GETs) and carbon-14 urea breath tests (14C UBTs) were used to measure the HP colonies quantitatively. The patients were assessed according to the following two criteria: (a) the HP colony number (i.e. high or low) and (b) the recorded duration of the GET (i.e. long or short). There was no statistically significant difference in the incidence of abnormal GET between high and low 14C UBT patients or in the incidence of abnormal 14C UBT between long and short GET cases. In conclusion, no significant relationship between HP-associated gastritis or ulcer disease and GET was found in this study. (orig.)

  8. Spanish teenage language and the COLAm-corpus

    Directory of Open Access Journals (Sweden)

    Annette Myre Jørgensen

    2013-04-01

    Full Text Available The results of the research done on Spanish teenage language with the COLAm corpus[1] of  Bergen University is presented in this paper. The teenagers are trying to find their their independence, separating themselves from the adults as well as the child generation a situation they share with their peers. The interaction with them is crucial and affects their language. The special characteristics of teenage talk like frequent discourse markers, anglicisms, intensifications and taboo words, not only create bonds within their members but work as identity markers. Keywords: corpus, teenage language, discourse markers, intensifiers, hedges, vocatives, loanwords, taboo words. [1] The Corpus Oral de Lenguaje Adolescente would not exist without Knut Hofland at UniDigital’s expertise and his collaboration with the transcribers of the COLA-corpus.

  9. Association of Helicobacter pylori with HLA-DR antigen expression in gastritis.

    OpenAIRE

    Wee, A; Teh, M; Kang, J Y

    1992-01-01

    AIMS: To assess the association between Helicobacter pylori-associated gastritis and HLA-DR antigen (class II antigen) expression. METHODS: Fifty endoscopic gastric biopsy specimens were studied for the presence of H pylori, degree and type of inflammation, and for HLA-DR antigen expression in the epithelium. The cases were chosen to represent different categories: inflamed gastric mucosa with (n = 13) and without (n = 20) H pylori, and non-inflamed mucosa (n = 17). RESULTS: The antigen was a...

  10. Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori associated gastritis.

    OpenAIRE

    Crabtree, J E; Shallcross, T M; Heatley, R V; Wyatt, J I

    1991-01-01

    The production of tumour necrosis factor alpha (TNF alpha) and interleukin-6 by human antral mucosa during short term culture in vitro has been measured by enzyme linked immunosorbent assay. TNF alpha and interleukin-6 concentrations in culture supernatants were significantly greater (p less than 0.001) in patients infected with Helicobacter pylori, all of whom had chronic gastritis, than in patients who were H pylori negative with histologically normal gastric mucosa. Among H pylori colonise...

  11. Sampling efficiency in the diagnosis of Helicobacter pylori infection and chronic active gastritis.

    OpenAIRE

    Nedenskov-Sørensen, P; Aase, S; Bjørneklett, A; O. Fausa; Bukholm, G

    1991-01-01

    The methods and sampling procedures used in the diagnosis of Helicobacter pylori infection and chronic active gastritis were evaluated. Five biopsy specimens for bacteriological cultivation and three specimens for histological examination were obtained endoscopically from a defined area of the gastric antral mucosae of 83 patients. An increase in the number of biopsy specimens for cultivation from one to five revealed only one more H. pylori-infected patient. H. pylori was isolated from 31 of...

  12. HELICOBACTER PYLORI-RELATED GASTRITIS AND LYMPHOID TISSUE HYPERPLASIA IN THE AGED

    Institute of Scientific and Technical Information of China (English)

    高天; 陈晓宇; 胡梅洁

    2003-01-01

    Objective To examine the relationship between Helicobacter pylori-related gastritis and the development of lymphoid tissue hyperplasia in the antral mucosa and to pursue its evolution after eradication of H.pylori in the aged. Methods Gastric antral mucosa biopsy specimens for microscopic study were obtained from 101 chronic gastritis patients over 60 years old with H.pylori-positive in the period from 2000 to 2001, and meanwhile those from 124 H.pylori-positive chronic gastritis patients under the age of 60 served as controls. Four to six weeks after a course of anti-H.pylori therapy, biopsy specimens were again obtained. Lym-phoid follicles and aggregates were counted and other pathologic features were scored according to the updated Sydney System for classification of chronic gastritis. Results The prevalence and density of lymphoid follicles and aggregates were significantly lower in the aged as compared with those in the control group, being 36. 6%(37/101) and 0. 41 vs. 72. 5%(90/124) and 0. 81, respectively(P<0.0001). The prevalence and density of lymphoid follicles and aggregates correlated strongly with the activity and severity of gastric antral mucosal inflammation in both groups. Eradication of H.pylori resulted in a decrease in the prevalence and density of lymphoid follicles and aggregates in both groups, especially in the aged group. Conclusion The prevalence and density of lymphoid follicles and aggregates in gastric antral mucosal biopsies correlated closely with H.phlori infection in the aged, therefore, anti-H.pylori treatment would be of importance to the aged patients infected with H.pylori.

  13. Campylobacter pylori, the spiral bacterium associated with human gastritis, is not a true Campylobacter sp.

    OpenAIRE

    Romaniuk, P J; Zoltowska, B; Trust, T J; Lane, D J; Olsen, G.J.; Pace, N R; Stahl, D A

    1987-01-01

    Comparison of partial 16S rRNA sequences from representative Campylobacter species indicates that the Campylobacter species form a previously undescribed basic eubacterial group, which is related to the other major groups only by very deep branching. This analysis was extended to include the spiral bacterium associated with human gastritis, Campylobacter pylori (formerly Campylobacter pyloridis). The distance between C. pylori and the other Campylobacter species is sufficient to exclude the p...

  14. Homocysteine Levels in Chronic Gastritis and Other Conditions: Relations to Incident Cardiovascular Disease and Dementia

    OpenAIRE

    Redéen, Stefan; Ryberg, Anna; Petersson, Fredrik; Eriksson, Olle; Nägga, Katarina; Borch, Kurt

    2009-01-01

    Background Homocysteine levels in circulation are determined by several factors and hyperhomocysteinemia is reportedly associated with cardiovascular diseases and dementia. The aim of this study is to determine the relation of chronic gastritis and other conditions to homocysteine levels and their relation to incident cardiovascular diseases and dementia. Methods An adult population-based cohort (N = 488) was screened for H. pylori infection, gastro-duodenitis (endoscopic biopsies), disease h...

  15. Gastroprotective effects of Nigella Sativa oil on the formation of stress gastritis in hypothyroidal rats

    OpenAIRE

    Abdel-Sater, Khaled A

    2009-01-01

    The aim of this study was to assess the effects of hypothyroidism on the development of acute cold restraint stress gastritis in rats and protective effect of Nigella sativa at the beginning of the acute cold restraint stress. 60 rats were randomly divided into six groups; the control (groups I), surgically thyroidectomized group (group II), acute cold restraint stressed group (group III), surgically thyroidectomized plus stressed group (group IV), Nigella sativa oil group (group V) and surgi...

  16. Gastritis caused by ingestion of eggs of puffer fish : a case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Dong Ho; Ko, Young Tae [Kyunghee Univ. College of Medicine, Seoul (Korea, Republic of)

    1996-09-01

    Tetrodotoxin is a neurotoxin, so gastrointestinal symptoms are very rare; these described in the literature are merely nausea and vomiting. Severe complications in the gastrointestinal tract caused by tetrodotoxin have not been radiologically reported. US and CT show thickening of the gastric wall and contraction of the lumen, and upper gastrointestinal series show shortening, lobulation and irregularity of the lesser and greater curvature of the body and antrum similar to the findings of corrosive gastritis.

  17. A survey on Candida colonization prevalence in patients with gastritis, duodenitis and peptic ulcer

    OpenAIRE

    Hashemi, S.J.; Kordbacheh, P.; Malekzadeh, R.; M Mehrabani

    2006-01-01

    Background: Prolonged antiacid and antibiotic usage in gasterointestinal diseases may predispose candidial colonization in GI tract. In order to isolate and diagnose of candida infections in patients with gastritis, duodenitis, gastric ulcer and duodenal ulcer, this study have been planned. Methods: We studied 300 biopsy specimens of patients referred to hospital, 51.7% of the patients were male and the others were female. The isolated fungi were identified by direct examination and culture o...

  18. Co-existence of Sarcina Organisms and Helicobacter pylori Gastritis/Duodenitis in Pediatric Siblings

    OpenAIRE

    Sauter, Jennifer L.; Nayar, Suresh K.; Anders, Paige D.; D’Amico, Michael; Butnor, Kelly J.; Wilcox, Rebecca L.

    2013-01-01

    Sarcina are gram-positive anaerobic bacteria found to be associated with delayed gastric emptying and gastric outlet obstruction. We describe two cases of Sarcina co-existing with Helicobacter pylori organisms in pediatric siblings presenting within four months of each other with pyloric obstruction secondary to severe gastritis/duodenitis. The co-existence of Sarcina and Helicobacter pylori has not, to our knowledge, been previously reported. Its characteristic tetrad packeted morphology per...

  19. Iron deficiency anemia in an athlete associated with Campylobacter pylori-negative chronic gastritis

    International Nuclear Information System (INIS)

    A 14-year-old athletic boy with a 1-year history of decreased exercise tolerance presented with unexplained iron deficiency anemia. Panendoscopy, colonoscopy, and barium contrast studies of the gastrointestinal tract were normal. However, persistent uptake of radionuclide using a 99mtechnetium-sucralfate scan suggested inflammation localized to the stomach. Mucosal biopsies demonstrated acute and chronic gastritis that was not associated with the presence of Campylobacter pylori

  20. Gastritis caused by ingestion of eggs of puffer fish : a case report

    International Nuclear Information System (INIS)

    Tetrodotoxin is a neurotoxin, so gastrointestinal symptoms are very rare; these described in the literature are merely nausea and vomiting. Severe complications in the gastrointestinal tract caused by tetrodotoxin have not been radiologically reported. US and CT show thickening of the gastric wall and contraction of the lumen, and upper gastrointestinal series show shortening, lobulation and irregularity of the lesser and greater curvature of the body and antrum similar to the findings of corrosive gastritis

  1. Traduction et corpus, corpus et recherche Translation and corpora, corpora and translation

    Directory of Open Access Journals (Sweden)

    Geoffrey Williams

    2011-09-01

    Full Text Available Dans l’enseignement des langues étrangères, la traduction est très souvent présente comme activité pédagogique. Dans les LEA de Lorient, nous ne prétendons pas former des traducteurs – notre spécialité reste le commerce international – mais en L3 une option rédaction/traduction a été ouverte pour ceux qui souhaitent se préparer à un Master en traduction ou rédaction. En plus de leurs cours de traduction, ces étudiants reçoivent des cours de lexicologie, de grammaire systémique et fonctionnelle, de traduction assistée et de linguistique de corpus. Dans cet article, nous montrerons le processus d’introduction des étudiants à la création de glossaires bilingues et phraséologiques et de dictionnaires de spécialité en construisant des corpus comparables à partir de textes électroniques.In second language teaching, translation is often seen as a pedagogical activity. In the Applied Languages with Business Studies (LEA course in Lorient, we do not claim to train translators—our speciality remains international trade—but in the third year we have opened a translation-technical writing course that is open to those who wish to go on to undertake a Master’s degree in these fields. In addition to training in translation, these students follow courses in lexicology, functional and systemic grammar, machine-assisted translation and corpus linguistics. In the following article, we shall show how the students are introduced to the building of bilingual phraseological glossaries and specialised dictionaries by building comparable corpora from electronic texts.

  2. Heterotopic respiratory mucosa of the uterine corpus

    Directory of Open Access Journals (Sweden)

    Sarala Ravindran

    2016-03-01

    Full Text Available A 47-year-old, single, Chinese woman presented with pain on the 1st day of menses for more than 30 years. Her dysmenorrhea worsened over years and underwent a total abdominal hysterectomy and bilateral salpingooophorectomy. The myometrium showed trabeculated appearance, and there were adhesions between ovaries and fallopian tubes. A pale solid brownish mass measuring 1.5 cm and times; 1 cm and times; 0.6 cm with fibrous whitish cut surfaces was present on the lateral wall of the uterus in the lower uterine segment. Histologically, adenomyosis and left ovarian endometriosis were confirmed. The lateral uterine wall nodule showed a tubular structure lined by ciliated pseudostratified columnar epithelium. Smooth muscle bundles were found around the entire tubular structure. Lobules of salivary type glands containing both serous and mucous cells are present. The pathological diagnosis of heterotopic respiratory mucosa (HRM was made. To our knowledge, this is the first reported case of HRM of the uterine corpus. [J Interdiscipl Histopathol 2016; 4(1.000: 26-28

  3. Lexical Meaning in the Corpus of Texts

    Directory of Open Access Journals (Sweden)

    Andrey Evgenyevich Bochkarev

    2015-11-01

    Full Text Available The methods and procedures of task solving in the field of semantics are inevitably influenced by the paradigm change. In particular, using text corpora, it is possible to re-examine problems that are traditional for lexical semantics, such as polysemy, the unity of meaning as well as opportunities for interpretation of units provided by a context or an intertext. Moreover, on analyzing the uses of words registered in corpora, one can realize that together with the system of language social norms are additional coding systems that also play a decisive role in meaning determination. Thus, the Russian Language National Corpus reveals that the notion of «high moral character» which is defined as «dignity» in dictionaries may imply quite different properties depending on the distribution of roles that are customary for the given culture. For males it can imply intellect, fidelity to duty, poise or stalk; for an unmarried woman it can mean comeliness, good reputation and the art to dress with elegance; when applied to a wife, the notion can imply conjugal fidelity, debonnaire and homemaking; a maiden should be smooth-tempered and of rosy disposition; a subordinate is expected to be obedient and able to execute orders. The author comes to the conclusion that it is social norms that may have modulative influence on the word meaning in every case of its actualization in speech.

  4. Brain potentials related to corpus cavernosum electromyography.

    Science.gov (United States)

    Ponseti, J; Bosinski, H A

    2010-01-01

    The aim of this study was to elucidate the relation between electrical activity in the corpus cavernosum (CC), penile responses and brain processes. EEG potentials, penile circumference and electrical activity of the CC (CC-EMG) were recorded simultaneously while male subjects were exposed to visual sexual stimuli. The trials were sorted by the penile response of the subjects (erection, maintenance or detumescence). The corresponding EEG recordings were subjected to independent component analysis (ICA) and then correlated with CC activity. We found that CC activity was decreased in the case of erection. EEG activity was found to be correlated with CC activity in most cases at the same instant or with subsequent CC activity. EEG activity at early time points after stimulus onset (brain processing and (ii) autonomous input reaches the CC in fractions of a second after sexual stimulus onset. Our experimental paradigm should be used for the study of psychogenic erectile dysfunctions and could help in the development of an objective measurement of this disturbance. PMID:20336074

  5. The Corpus of English as Lingua Franca in Academic Settings.

    Science.gov (United States)

    Mauranen, Anna

    2003-01-01

    Describes a project to make a corpus of English spoken as a lingua franca in university settings in Finland. This corpus is one of the first to address the need for corpora that show the target for English-as-a-Foreign-Language learners whose goal is not to speak with native speakers but to interact in communities where English is a lingua franca.…

  6. Cavernous Angioma of the Corpus Callosum Presenting with Acute Psychosis

    OpenAIRE

    Giacomo Pavesi; Francesco Causin; Alberto Feletti

    2014-01-01

    Psychiatric symptoms may occasionally be related to anatomic alterations of brain structures. Particularly, corpus callosum lesions seem to play a role in the change of patients’ behavior. We present a case of a sudden psychotic attack presumably due to a hemorrhagic cavernous angioma of the corpus callosum, which was surgically removed with complete resolution of symptoms. Although a developmental defect like agenesis or lipoma is present in the majority of these cases, a growing lesion of t...

  7. Clinical significance of the corpus callosum in cerebral palsy

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Eun Ja; Kim, Ji Chang [The Catholic University of Korea, Seoul (Korea, Republic of); Kim, Jong Chul [School of Medicine, Chungnam National University, Taejon (Korea, Republic of); And Others

    2000-10-01

    To evaluate, using magnetic resonance (MR) imaging, the clinal significance of the corpus callosum by measuring the size of various portions of the corpus callosum in children with cerebral palsy, and in paired controls. Fifty-two children (30 boys and 22 girls aged between six and 96 (median, 19) months) in whom cerebral palsy was clinically diagnosed underwent MR imaging. There were 23 term patients and 29 preterm, and the control group was selected by age and sex matching. Clinal subtypes of cerebral palsy were classified as hemiplegia (n=14), spastic diplegia (n=22), or spastic quadriplegia (n=16), and according to the severity of motor palsy, the condition was also classified as mild (n=26), moderate (n=13), or severe (n=13). In addition to the length and height of the corpus callosum, the thickness of its genu, body, transitional zone and splenium, as seen on midsagittal T1-weighted MR images, were also measured. Differences in the measured values of the two groups were statistically analysed and differences in the size of the corpus callosum according to the clinical severity and subtypes of cerebral palsy, and gestational age, were also assessed. Except for height, the measured values of the corpus callosum in patients with cerebral palsy were significantly less than those of the control group (p less than 0.05). Its size decreased according to the severity of motor palsy. Compared with term patients, the corpus callosum in preterm patients was considerably smaller (p less than 0.05). There was statistically significant correlation between the severity of motor palsy and the size of the corpus callosum. Quantitative evaluation of the corpus callosum might be a good indicator of neurologic prognosis, and a sensitive marker for assessing the extent of brain injury.

  8. A multimodal corpus of speech to infant and adult listeners

    OpenAIRE

    Johnson, E.K.; Laheij, M.A.A.; Ernestus, M.T.C.; Cutler, A.

    2013-01-01

    An audio and video corpus of speech addressed to 28 11-month-olds is described. The corpus allows comparisons between adult speech directed towards infants, familiar adults and unfamiliar adult addressees, as well as of caregivers’ word teaching strategies across word classes. Summary data show that infant-directed speech differed more from speech to unfamiliar than familiar adults; that word teaching strategies for nominals versus verbs and adjectives differed; that mothers mostly addressed ...

  9. The Shona Corpus and the Problem of Tagging?

    OpenAIRE

    Emmanuel Chabata

    2011-01-01

    Abstract: In this paper the writer examines problems the African Languages Lexical (ALLEX) Project (at present the African Languages Research Institute (ALRI? encountered while tagging the Shona corpus. The problems to be highlighted include general problems which apply to more than one language as well as problems peculiar to Shona. The paper was inspired by the challenges the writer encountered when he took part in building the Shona corpus. An analysis of the problems that most co...

  10. Hereditary spastic paraplegia with a thin corpus callosum

    Energy Technology Data Exchange (ETDEWEB)

    Somasundaram, Sivaraman; Kesavadas, Chandrasekharan [Sree Chitra Tirunal Institute for Medical Sciences and Technology, Department of Imaging Sciences and Interventional Radiology, Trivandrum (India); Raghavendra, Seetharam; Singh, Atampreet; Nair, Muraleedharan [Sree Chitra Tirunal Institute for Medical Sciences and Technology, Department of Neurology, Trivandrum (India)

    2007-05-15

    We report a 15-year-old boy with autosomal recessive complicated hereditary spastic paraplegia with a thin corpus callosum (HSP-TCC). The involvement of the corpus callosum was characteristic with the genu and body predominantly affected with relative sparing of the splenium. HSP-TCC is being increasingly recognized over a wider geographical area than earlier believed. We now report a case of HSP-TCC from the Indian subcontinent. (orig.)

  11. Experimental Polish-Lithuanian Corpus with the Semantic Annotation Elements

    Directory of Open Access Journals (Sweden)

    Danuta Roszko

    2015-06-01

    Full Text Available Experimental Polish-Lithuanian Corpus with the Semantic Annotation ElementsIn the article the authors present the experimental Polish-Lithuanian corpus (ECorpPL-LT formed for the idea of Polish-Lithuanian theoretical contrastive studies, a Polish-Lithuanian electronic dictionary, and as help for a sworn translator. The semantic annotation being brought into ECorpPL-LT is extremely useful in Polish-Lithuanian contrastive studies, and also proves helpful in translation work.

  12. Bilingual Corpus - Digital Repository for Preservation of Language Heritage

    OpenAIRE

    Dimitrova, Ludmila; Garabík, Radovan

    2012-01-01

    The article briefly reviews bilingual Slovak-Bulgarian/Bulgarian-Slovak parallel and aligned corpus. The corpus is collected and developed as results of the collaboration in the frameworks of the joint research project between Institute of Mathematics and Informatics, Bulgarian Academy of Sciences, and Ľ. Štúr Institute of Linguistics, Slovak Academy of Sciences. The multilingual corpora are large repositories of language data with an important role in preserving and supporting the world's cu...

  13. Facial emotion recognition in agenesis of the corpus callosum

    OpenAIRE

    Bridgman, Matthew W; Brown, Warren S.; Spezio, Michael L.; Leonard, Matthew K.; Adolphs, Ralph; Paul, Lynn K

    2014-01-01

    Background: Impaired social functioning is a common symptom of individuals with developmental disruptions in callosal connectivity. Among these developmental conditions, agenesis of the corpus callosum provides the most extreme and clearly identifiable example of callosal disconnection. To date, deficits in nonliteral language comprehension, humor, theory of mind, and social reasoning have been documented in agenesis of the corpus callosum. Here, we examined a basic social ability as yet not ...

  14. Building a Singapore Learner Corpus of English Writing for Pedagogy

    OpenAIRE

    Ruihua, Zhang; Libo, Guo; Huaqing, Hong

    2015-01-01

    This paper documents the development of a Singapore learner corpus of English writing for pedagogy, which has been constructed at Nanyang Technological University, Singapore. This corpus comprises sample English artefacts produced by students at 3 levels, i.e. Primary 6 (Year 6), Secondary 4 (Year 10) and Junior College 2 (Year 12). It is built to capture and compare learners’ developmental features in terms of vocabulary, grammar and discoursal devices at different learning stages and theref...

  15. Centralised National Corpus of Electronic Theses and Dissertations

    OpenAIRE

    Kravjar, Julius (CVTISR); Duskova, Marta (CVTISR); GreyNet, Grey Literature Network Service

    2013-01-01

    The paper analyzes the creation and two years' operation of the national corpus of bachelor, master, diploma, dissertation and habilitation theses of Slovak higher education institutions and the follow-up plagiarism detection system. The national corpus is called The Central Re-pository of Theses and Dissertations (CRTD). Each thesis has to be entered in CRTD before defence and it is then checked for plagiarism. Includes: Conference preprint, Powerpoint presentation, Abstract and Biographi...

  16. Hereditary spastic paraplegia with a thin corpus callosum

    International Nuclear Information System (INIS)

    We report a 15-year-old boy with autosomal recessive complicated hereditary spastic paraplegia with a thin corpus callosum (HSP-TCC). The involvement of the corpus callosum was characteristic with the genu and body predominantly affected with relative sparing of the splenium. HSP-TCC is being increasingly recognized over a wider geographical area than earlier believed. We now report a case of HSP-TCC from the Indian subcontinent. (orig.)

  17. Experimental Polish-Lithuanian Corpus with the Semantic Annotation Elements

    OpenAIRE

    Danuta Roszko; Roman Roszko

    2015-01-01

    Experimental Polish-Lithuanian Corpus with the Semantic Annotation ElementsIn the article the authors present the experimental Polish-Lithuanian corpus (ECorpPL-LT) formed for the idea of Polish-Lithuanian theoretical contrastive studies, a Polish-Lithuanian electronic dictionary, and as help for a sworn translator. The semantic annotation being brought into ECorpPL-LT is extremely useful in Polish-Lithuanian contrastive studies, and also proves helpful in translation work.

  18. Clinical significance of the corpus callosum in cerebral palsy

    International Nuclear Information System (INIS)

    To evaluate, using magnetic resonance (MR) imaging, the clinal significance of the corpus callosum by measuring the size of various portions of the corpus callosum in children with cerebral palsy, and in paired controls. Fifty-two children (30 boys and 22 girls aged between six and 96 (median, 19) months) in whom cerebral palsy was clinically diagnosed underwent MR imaging. There were 23 term patients and 29 preterm, and the control group was selected by age and sex matching. Clinal subtypes of cerebral palsy were classified as hemiplegia (n=14), spastic diplegia (n=22), or spastic quadriplegia (n=16), and according to the severity of motor palsy, the condition was also classified as mild (n=26), moderate (n=13), or severe (n=13). In addition to the length and height of the corpus callosum, the thickness of its genu, body, transitional zone and splenium, as seen on midsagittal T1-weighted MR images, were also measured. Differences in the measured values of the two groups were statistically analysed and differences in the size of the corpus callosum according to the clinical severity and subtypes of cerebral palsy, and gestational age, were also assessed. Except for height, the measured values of the corpus callosum in patients with cerebral palsy were significantly less than those of the control group (p less than 0.05). Its size decreased according to the severity of motor palsy. Compared with term patients, the corpus callosum in preterm patients was considerably smaller (p less than 0.05). There was statistically significant correlation between the severity of motor palsy and the size of the corpus callosum. Quantitative evaluation of the corpus callosum might be a good indicator of neurologic prognosis, and a sensitive marker for assessing the extent of brain injury

  19. Helicobacter pylori detection in chronic gastritis: a comparison of staining methods

    International Nuclear Information System (INIS)

    Background: Helicobacter pylori is an important cause of chronic gastritis, gastric ulceration and gastric malignancies as gastric carcinoma and MALT lymphoma. Its definitive diagnosis is based on histopathology. Routine H and E stain is not very effective in its detection, immune-stains and fluorescent stains are costly. Need for simple cheap and sensitive stain has always been a topic of hot debate and extensive research. Method: paraffin embedded blocks of all adult patients diagnosed as chronic gastritis/gastric ulceration with no accompanying gastric pathology as hypertrophic gastropathys, and neoplasias were taken into study. Three sections of 4 micron were cut and stained with routine H and E, Giemsa, and Cresyl fast violet. Results: Total number of patients was 50. Out of these 37 (74%) were males and 13 (26%) were females. Mean age of the patients was 50.4 years. Thirty-four percent (34%) were positive in normal H and E stain, 68% were positive in Giemsa and 76% were positive in Cresyl fast violet. Conclusion: Cresyl fast violet is a good stain for diagnosis of H. pylori gastritis. (author)

  20. Observation of Pain-Sensitive Points along the Meridians in Patients with Gastric Ulcer or Gastritis

    Directory of Open Access Journals (Sweden)

    Hui Ben

    2012-01-01

    Full Text Available This study aims to investigate the sensitization of human skin points along certain meridians related to visceral disease by using the pressure-pain threshold (PPT as an indicator. We detected and compared the PPTs of people with and without gastric ulcer or gastritis on the related acupoints, abdomen area, and back area with von Frey detector and observed the similarities and differences under their respective physiological and pathological states. The results showed that (1 the PPTs of patients with gastric ulcer on related acupoints decreased significantly compared with the control group; (2 there was no significant difference in PPT between the chosen points of the measured meridian and the adjacent nonacupoints; (3 there was an apparent distribution of tender points on the relevant abdomen and back regions of patients with gastric ulcer or gastritis, but none was found on the control group; (4 the pain-sensitive points of gastric ulcer and gastritis patients were BURONG (ST19, LIANGMEN (ST21, and HUAROUMEN (ST24 of the stomach meridian on the abdominal region and PISHU (BL20, WEISHU (BL21, and WEICANG (BL50 on the back, among others The results suggest that the practical significance of acupoints may lie in its role as a relatively sensitive functional area. In a pathological state, the reflex points on the skin which are related to certain visceral organs become sensitive and functionally intensify.

  1. Expression of matrix metalloproteinases 2 and 9 in human gastric cancer and superficial gastritis

    Directory of Open Access Journals (Sweden)

    Clara Luz Sampieri, Sol de la Peña, Mariana Ochoa-Lara, Roberto Zenteno-Cuevas, Kenneth León-Córdoba

    2010-03-01

    Full Text Available AIM: To assess expression of matrix metalloproteinases 2 (MMP2 and MMP9 in gastric cancer, superficial gastritis and normal mucosa, and to measure metalloproteinase activity.METHODS: MMP2 and MMP9 mRNA expression was determined by quantitative real-time polymerase chain reaction. Normalization was carried out using three different factors. Proteins were analyzed by quantitative gelatin zymography (qGZ.RESULTS: 18S ribosomal RNA (18SRNA was very highly expressed, while hypoxanthine ribosyltransferase-1 (HPRT-1 was moderately expressed. MMP2 was highly expressed, while MMP9 was not detected or lowly expressed in normal tissues, moderately or highly expressed in gastritis and highly expressed in cancer. Relative expression of 18SRNA and HPRT-1 showed no significant differences. Significant differences in MMP2 and MMP9 were found between cancer and normal tissue, but not between gastritis and normal tissue. Absolute quantification of MMP9 echoed this pattern, but differential expression of MMP2 proved conflictive. Analysis by qGZ indicated significant differences between cancer and normal tissue in MMP-2, total MMP-9, 250 and 110 kDa bands.CONCLUSION: MMP9 expression is enhanced in gastric cancer compared to normal mucosa; interpretation of differential expression of MMP2 is difficult to establish.

  2. A survey on Candida colonization prevalence in patients with gastritis, duodenitis and peptic ulcer

    Directory of Open Access Journals (Sweden)

    "S.J. Hashemi

    2006-07-01

    Full Text Available Background: Prolonged antiacid and antibiotic usage in gasterointestinal diseases may predispose candidial colonization in GI tract. In order to isolate and diagnose of candida infections in patients with gastritis, duodenitis, gastric ulcer and duodenal ulcer, this study have been planned. Methods: We studied 300 biopsy specimens of patients referred to hospital, 51.7% of the patients were male and the others were female. The isolated fungi were identified by direct examination and culture of specimens. Results: Forthy four cases of yeasts were isolated in this investigation. Isolated yeasts have been identified as follows: 26 cases of C.albicance , I case C.tropicalis, 2 cases of C.krusei, and finally 1 case of unknown yeast. Conclusion: All the patients had a positive history of long lasting antacid taking for gastric ulser or gastritis. Candidiasis must be investigated in patients with gastritis, duodenitis and gastric ulcer, who are refractory to classic therapies and also in patients who have the chronic disease .

  3. Helicobacter-pylori Negative Gastritis in Children—A New Clinical Enigma

    Directory of Open Access Journals (Sweden)

    Yoram Elitsur

    2014-10-01

    Full Text Available The decrease in the prevalence of Helicobacter pylori (Hp infection in children in the world gave rise to a new pathological finding termed as Hp-negative gastritis. Unfortunately, the term “Hp-negative gastritis” has not been identified as a pathological process and has the status of a “second cousin”; in most publications it was never mentioned as a subject to be dealt with, but was “left over” data that was never the topic of the manuscripts’ discussions. Only recently has the topic captured the attention of the pathologists who described this phenomenon in adults, yet the pathological and/or clinical spectrum or significance of this phenomenon has not been adequately investigated. In the current manuscript we describe Hp-negative gastritis in children, summarize its clinical prevalence and touch upon the possible etiology, pathology, and/or therapeutic implication. Overall, this review has concluded that Hp-negative gastritis is a pathological phenomenon in children that needs further investigation, and to date, as the title suggests, is a new clinical enigma that needs to be considered.

  4. Cyclooxygenase-2 Expression in Chronic Gastritis and Gastric Carcinoma, Correlation with Prognostic Parameters

    International Nuclear Information System (INIS)

    Background: Cyclooxygenase-2 (Cox-2) is the inducible form of cyclooxygenase enzyme. Cox-2 is induced in numerous processes such as cellular growth, differentiation, inflammation and tumorigenesis. Purpose: Assessment of Cox-2 expression in chronic gastritis s and gastric carcinoma. Material and Methods: Sixteen chronic gastritis (CG) and 43 gastric carcinoma cases were subjected to an immunohistochemical approach using anti Cox-2 antibody. Results: All CG cases displayed positive epithelial Cox-2 expression with only 25% positivity for stromal expression. Eighty six percent of gastric carcinoma showed epithelial Cox-2 expression that was significantly correlated with lymph node involvement (p=0.01), advanced stage (p=0.01), high micro vessel density (MVD) (p=0.0001), vascular invasion (p=0.002), peri neural invasion (p=0.0 I) and low apoptotic count (p<0.0001). Stromal Cox-2 expression was seen in 79% of gastric carcinoma cases and was significantly associated with low apoptotic count (p=0.0007), vascular invasion (p=0.001) and high micro vessel density (MVD) (p=0.0003). Only stromal Cox2 expression was significantly higher in gastric carcinoma than chronic gastritis (p=0.0001). Conclusions: Cox-2 appears to be involved in gastric carcinoma progression as it promotes angio genesis, suppresses apoptosis and facilitates invasion and metastasis Double expression of Cox-2 in gastric carcinoma epithelium and stroma and significant association between them demonstrate a paracrine cross effect between stromal and malignant epithelium

  5. Diagnostic Utility of Nodular Gastritis in Children with Chronic Abdominal Pain Undergoing Endoscopy

    Directory of Open Access Journals (Sweden)

    Seddiqe Amini-Ranjbar

    2008-01-01

    Full Text Available This study was aimed to describe the endoscopic picture and laboratory findings in children with chronic abdominal pain and to determine the utility of nodular gastritis in diagnosing HPI in these patients. This prospective study was done between November, 2004 and May, 2007. A total of 70 patients (36 male and 34 female aged 3-14 years, underwent upper endoscopy. H-pylori infection was diagnosed when both urease test and histology were positive for the infection. Seventy percent (n = 49 of them were diagnosed to have endoscopic nodular gastritis. HPI was confirmed in 33 (47.1% of 70 patients. The endoscopic antral nodularity had a sensitivity of 100%, specificity of 56.8%, positive predictive value of 67.3%, negative predictive value of 100% and a positive LR of 2.32 for diagnosis of HPI. It may be recommended that if nodular gastritis observed in a pediatric patient with chronic abdominal pain he/she should be investigated to exclude HPI otherwise no further work up is necessary to confirm HPI.

  6. Chinese EFL Teachers' Attitudes toward Corpus Use in Collocation Instruction

    Institute of Scientific and Technical Information of China (English)

    郭敏

    2014-01-01

    The purpose of the present study was to investigate Chinese EFL (English as a Foreign Language) teachers ’attitudes to-ward corpus use in collocation instruction. Fourteen Chinese EFL teachers from seven different colleges or universities answered a questionnaire asking their perceptions about corpus use in collocation instruction. The statistical analysis revealed that significant difference (t=2.449, df.=9, p=.037<0.1) was found between males and females in their perception of the learnability of the search-ing technique in collocation corpus. Besides, the result also revealed that significant differences were found between novice and experienced teachers’perception of helpfulness of corpus in writing native-like sentences (t=5.75, df=11, p<0.1), identifying col-location errors in English (t=5.75, df=11, p<0.1), usefulness of corpus in searching for English collocations (t=2.93, df=12, p<0.1), and advocacy of corpus to colleagues(t=5.75, df=11, p<0.1). Finally, some pedagogical implications were put forward.

  7. A Corpus Investigation of Syntactic Embedding in Pirahã

    Science.gov (United States)

    Futrell, Richard; Stearns, Laura; Everett, Daniel L.

    2016-01-01

    The Pirahã language has been at the center of recent debates in linguistics, in large part because it is claimed not to exhibit recursion, a purported universal of human language. Here, we present an analysis of a novel corpus of natural Pirahã speech that was originally collected by Dan Everett and Steve Sheldon. We make the corpus freely available for further research. In the corpus, Pirahã sentences have been shallowly parsed and given morpheme-aligned English translations. We use the corpus to investigate the formal complexity of Pirahã syntax by searching for evidence of syntactic embedding. In particular, we search for sentences which could be analyzed as containing center-embedding, sentential complements, adverbials, complementizers, embedded possessors, conjunction or disjunction. We do not find unambiguous evidence for recursive embedding of sentences or noun phrases in the corpus. We find that the corpus is plausibly consistent with an analysis of Pirahã as a regular language, although this is not the only plausible analysis. PMID:26934636

  8. A Corpus Investigation of Syntactic Embedding in Pirahã.

    Science.gov (United States)

    Futrell, Richard; Stearns, Laura; Everett, Daniel L; Piantadosi, Steven T; Gibson, Edward

    2016-01-01

    The Pirahã language has been at the center of recent debates in linguistics, in large part because it is claimed not to exhibit recursion, a purported universal of human language. Here, we present an analysis of a novel corpus of natural Pirahã speech that was originally collected by Dan Everett and Steve Sheldon. We make the corpus freely available for further research. In the corpus, Pirahã sentences have been shallowly parsed and given morpheme-aligned English translations. We use the corpus to investigate the formal complexity of Pirahã syntax by searching for evidence of syntactic embedding. In particular, we search for sentences which could be analyzed as containing center-embedding, sentential complements, adverbials, complementizers, embedded possessors, conjunction or disjunction. We do not find unambiguous evidence for recursive embedding of sentences or noun phrases in the corpus. We find that the corpus is plausibly consistent with an analysis of Pirahã as a regular language, although this is not the only plausible analysis. PMID:26934636

  9. Corpus sp{\\'e}cialis{\\'e} et ressource de sp{\\'e}cialit{\\'e}

    OpenAIRE

    Jacquemin, Bernard; Ploux, Sabine

    2008-01-01

    "Semantic Atlas" is a mathematic and statistic model to visualise word senses according to relations between words. The model, that has been applied to proximity relations from a corpus, has shown its ability to distinguish word senses as the corpus' contributors comprehend them. We propose to use the model and a specialised corpus in order to create automatically a specialised dictionary relative to the corpus' domain. A morpho-syntactic analysis performed on the corpus makes it possible to ...

  10. Prospective study in the management of high-dose radioactive iodine therapy induced gastritis

    International Nuclear Information System (INIS)

    Full text: Gastritis is simply defined as inflammation of the gastric mucosa. In post-RAI patients, this is one of the most common complications that are encountered. Some patients may even require repetitive administration of high doses of radioactive iodine (I-131). Small doses of radiation (up to 1500 R) cause reversible mucosal damage, whereas higher radiation doses cause irreversible damage with atrophy and ischemic-related ulceration. Reversible changes consist of degenerative changes in epithelial cells and nonspecific chronic inflammatory infiltrate in the lamina propria. Higher amounts of radiation cause permanent mucosal damage, with atrophy of fundic glands, mucosal erosions, and capillary hemorrhage. Associated submucosal endarteritis results in mucosal ischemia and secondary ulcer development. Recurrent gastritis, if left untreated, may be a predisposing factor for gastric malignancy. Methods:A total of thirty post-RAI subjects were evaluated for signs and symptoms of gastritis and were divided into 3 groups which were given drugs for gastritis (H2-receptor antagonist, proton pump inhibitor, and sucralfate). Survey forms were distributed to evaluate the presence of nausea, vomiting, epigastric pain (graded according to severity of pain), and gastrointestinal bleeding. Results were tallied accordingly. Results and Discussion: In a total of 3 subjects who were given sucralfate, all of them did not experience any nausea and vomiting. One subject experienced mild epigastric discomfort and another subject was able to experience a non-specific symptom of abdominal bloatedness. (Note: Subjects are still for completion) In theory, radiation irritates the mucosa causing inflammation and mucosal damage which is further irritated by gastric acid secretion. The administration of H2-receptor blockers and proton pump inhibitors only inhibit gastric acid secretion while existing inflammation of mucosa due to high doses of radiation is left untreated. However

  11. Predictability of short implants (< 10 mm) as a treatment option for the rehabilitation of atrophic maxillae. A systematic review

    OpenAIRE

    Sierra-Sánchez, José-Luis; García-Sala-Bonmatí, Fernando; Martínez-González, Amparo; García-Dalmau, Carlos; Mañes-Ferrer, José-Félix; Brotons-Oliver, Alejandro

    2016-01-01

    Background Short implants (< 10 mm) are one of the treatment options available in cases of limited vertical bone. A purpose of this paper is to evaluate the predictability of short implants as an alternative to technically molthough such implants are now widely used, there is controversy regarding their clinical reliability. There complex treatments in patients with atrophic maxillae, based on a systematic review of the literature and the analysis of the implant survival rates, changes in per...

  12. Split Face Comparative Study of Microneedling with PRP Versus Microneedling with Vitamin C in Treating Atrophic Post Acne Scars

    OpenAIRE

    Simran Chawla

    2014-01-01

    Introduction: Acne scars are largely preventable complications of acne. 95% of the scars occur over the face thus impacting the quality of life. Correction of scars is the priority for acne patients. Materials and Methods: Thirty patients with post acne atrophic facial scars attending the OPD during the period from April to October 2013 were offered four sittings of microneedling with PRP on one side and microneedling with vitamin C on other side of the face at an interval of 1 month. Results...

  13. The Effect of Pimecrolimus Cream 1% Compared with Triamcinolone Acetonide Paste in Treatment of Atrophic-Erosive Oral Lichen Planus

    OpenAIRE

    Atessa Pakfetrat; Zahra Delavarian; Farnaz Falaki; Mahboubeh Khorashadizadeh; Mina Saba

    2015-01-01

    Introduction: Oral lichen planus (OLP) is a common chronic mucocutaneous disease. Patients with atrophic and erosive types of OLP often have symptoms of soreness, and require proper treatment. The main treatment for OLP has been the administration of topical or systemic corticosteroids. The objective of this study was to compare the efficacy of adcortyl cream (triamcinolone acetonide in orabase) with topical pimecrolimus cream for the treatment of erosive OLP.   Materials and Methods: Twenty-...

  14. Prosthetic management of the atrophic mandible using endosseous implants and overdentures: a six year review.

    Science.gov (United States)

    Chan, M F; Johnston, C; Howell, R A; Cawood, J I

    1995-11-11

    This paper presents the treatment results and experiences gained from a retrospective study of patients treated with the IMZ osseo-integrated implant system and mandibular overdentures. Patients experiencing problems wearing conventional dentures were assessed by the implant team and 65 cases were treated with 154 endosseous implants placed in the edentulous mandible. Two to four implants were placed in each case and in addition some patients have had augmentation of the mandible with hydroxyapatite. The definitive mandibular prostheses were supported by both implants and the residual ridges. A variety of retention systems were utilised, which included different types of bar and clip, stud attachments, and magnets. The patients have been followed up regularly and evaluated after periods of between one and six years. Six implants have failed over this time resulting in a success rate of over 96%. Most patients expressed a high degree of satisfaction with their new overdentures. There was, however, a considerable burden of maintenance care required for the patient group examined. The findings demonstrate that implant retained overdentures offer a highly effective means of oral rehabilitation for the atrophic mandible, restoring both oral function and facial form. PMID:7495628

  15. Impaired translocation of GLUT4 results in insulin resistance of atrophic soleus muscle.

    Science.gov (United States)

    Xu, Peng-Tao; Song, Zhen; Zhang, Wen-Cheng; Jiao, Bo; Yu, Zhi-Bin

    2015-01-01

    Whether or not the atrophic skeletal muscle induces insulin resistance and its mechanisms are not resolved now. The antigravity soleus muscle showed a progressive atrophy in 1-week, 2-week, and 4-week tail-suspended rats. Hyperinsulinemic-euglycemic clamp showed that the steady-state glucose infusion rate was lower in 4-week tail-suspended rats than that in the control rats. The glucose uptake rates under insulin- or contraction-stimulation were significantly decreased in 4-week unloaded soleus muscle. The key protein expressions of IRS-1, PI3K, and Akt on the insulin-dependent pathway and of AMPK, ERK, and p38 on the insulin-independent pathway were unchanged in unloaded soleus muscle. The unchanged phosphorylation of Akt and p38 suggested that the activity of two signal pathways was not altered in unloaded soleus muscle. The AS160 and GLUT4 expression on the common downstream pathway also was not changed in unloaded soleus muscle. But the GLUT4 translocation to sarcolemma was inhibited during insulin stimulation in unloaded soleus muscle. The above results suggest that hindlimb unloading in tail-suspended rat induces atrophy in antigravity soleus muscle. The impaired GLUT4 translocation to sarcolemma under insulin stimulation may mediate insulin resistance in unloaded soleus muscle and further affect the insulin sensitivity of whole body in tail-suspended rats. PMID:25713812

  16. On the Feasibility of Utilizing Allogeneic Bone Blocks for Atrophic Maxillary Augmentation

    Directory of Open Access Journals (Sweden)

    Alberto Monje

    2014-01-01

    Full Text Available Purpose. This systematic review was aimed at assessing the feasibility by means of survival rate, histologic analysis, and causes of failure of allogeneic block grafts for augmenting the atrophic maxilla. Material and Methods. A literature search was conducted by one reviewer in several databases. Articles were included in this systematic review if they were human clinical trials in which outcomes of allogeneic bone block grafts were studied by means of survival rate. In addition other factors were extracted in order to assess their influence upon graft failure. Results. Fifteen articles fulfilled the inclusion criteria and subsequently were analyzed in this systematic review. A total of 361 block grafts could be followed 4 to 9 months after the surgery, of which 9 (2.4% failed within 1 month to 2 months after the surgery. Additionally, a weighed mean 4.79 mm (95% CI: 4.51–5.08 horizontal bone gain was computed from 119 grafted sites in 5 studies. Regarding implant cumulative survival rate, the weighed mean was 96.9% (95% CI: 92.8–98.7%, computed from 228 implants over a mean follow-up period of 23.9 months. Histologic analysis showed that allogeneic block grafts behave differently in the early stages of healing when compared to autogenous block grafts. Conclusion. Atrophied maxillary reconstruction with allogeneic bone block grafts represents a reliable option as shown by low block graft failure rate, minimal resorption, and high implant survival rate.

  17. Corpus callosum in aging and dementia.

    Science.gov (United States)

    Frederiksen, Kristian Steen

    2013-10-01

    The overarching objective of the thesis was to investigate the morphological changes in the corpus callosum (CC) in aging and dementia in relation to its role in cognitive and motor decline. The CC is the largest white matter tract in the brain, containing upwards of 200 million axons, and is believed important for communication and interaction between the two cerebral hemispheres. Historically, the role of white matter, including the CC, in relation to cognitive function has often been eclipsed by the predominance of the cortex, and led to a "corticocentric" view of the brain and cognitive function. However, from the 1960s and onwards, the role of lesions in the white matter in the appearence of cognitive deficits and diseases such as dementia has become increasingly evident. Many studies have indicated that AD is associated with CC atrophy, but the precise pattern of subregional CC atrophy in different disease stages remains undetermined. In study I, we establish that atrophy is present primarily in the posterior CC early in AD, and that atrophy of the CC is associated with faster disease progression. This finding supports a model where posterior atrophy is the earliest changes in the CC in AD patients, with atrophy of anterior CC being a later pathological event. To further elucidate the role of CC atrophy in dementia, we examined a population of 329 elderly subjects, and found that a higher rate of tissue loss in posterior CC is associated with an increased risk of dementia. This study represents the first to examine CC in elderly subjects longitudinally. In the same cohort, we investigated whether impairment in specific cognitive domains was associated with CC tissue loss. Previous studies had shown that processing speed and executive functions may be particularly reliant on the CC. Our findings indicated that CC tissue loss leads to selective impairment of processing speed but not memory or executive function deficits. Finally, CC tissue loss was also

  18. Incidencia actual de la gastritis: una breve revisión

    Directory of Open Access Journals (Sweden)

    Julio César Fernández Travieso

    2014-01-01

    Full Text Available Uno de los trastornos que con más frecuencia afecta a la población mundial lo constituyen las enfermedades gastrointestinales, las cuales se encuentran entre las primeras causas de muerte, al estar incluidas entre ellas el cáncer colorectal y el gástrico. Entre las enfermedades gastrointestinales más comunes se encuentra la gastritis, padecimiento de etiología multifactorial que puede originarse por diversas causas, entre las que se incluyen las infecciones por bacterias como Helicobacter pylori, Echericha coli, Salmonella, el consumo de antiinflamatorios no esteroidales, consumo excesivo de alcohol, fumar, comer alimentos picantes o salados, cirugía mayor, lesiones traumáticas o quemaduras, infección grave, anemia perniciosa, enfermedades autoinmunológicas y el reflujo biliar crónico. Su diagnóstico se realiza por medio de la gastroscopia, exámenes de sangre, cultivo de heces y el estudio histopatológico de la biopsia de mucosa gástrica previamente extraída de la exploración endoscópica. En esta revisión se aborda brevemente la gastritis, su clasificación y etiología. Además, se discuten sus factores de riesgo y se enfatiza su control como medida clave en las estrategias de prevención, así como se aborda el adecuado tratamiento farmacológico para su manejo. Se concluye que la mejor manera de reducir la gastritis radica en su prevención, control de los factores de riesgo, estilo de vida saludable y su adecuado manejo terapéutico.

  19. Trilingual aligned corpus – current state and new applications

    Directory of Open Access Journals (Sweden)

    Ludmila Dimitrova

    2014-09-01

    Full Text Available Trilingual aligned corpus – current state and new applicationsThis article describes current state of a trilingual parallel corpus consisted of texts in two Slavic (Bulgarian and Polish and one Baltic language (Lithuanian. The corpus contains original literary texts (fiction, novels, and short stories in one of the three languages with translations to the other two, and texts in other languages translated into Bulgarian, Polish, and Lithuanian. A part of the texts are aligned at the sentence level. The authors propose a semantic annotation of verbs appearing in these aligned texts that will facilitate contrastive studies of natural languages. A theoretical background for the proposed semantic annotation is briefly also discussed.

  20. Subtotal gastrectomy for diffused hemorrhagic gastritis induced by radiation, following liver resection for hilar cholangiocarcinoma. A case report

    Science.gov (United States)

    Vasileios, Tatsis; Evaggelia, Peponi; Georgios, Papadopoulos; Periklis, Tsekeris; Michael, Fatouros; Georgios, Glantzounis

    2015-01-01

    Introduction A rare case of hemorrhagic gastritis induced by radiation is presented, which was resistant to conservative treatment and required subtotal gastrectomy. Presentation of case A 56-year-old male was initially undergone right hepatectomy, resection of the extrahepatic biliary tree, hilar lymph node dissection and hepatico-jejunostomy due to advanced hilar cholangiocarcinoma. Because of the extent of the disease, chemo-radiotherapy was administered. The patient received a total radiotherapy dose of 57.6 Gy in 32 sessions. Unfortunately, diffused hemorrhagic gastritis induced by radiation was developed, which was resistant to conservative treatment (endoscopic hemostasis, transfusion). A subtotal gastrectomy was performed. The patient is in good condition 45 months after the liver resection, but with local recurrence. Conclusion In resistant situations to conservative treatment and recurred bleeding of diffused hemorrhagic gastritis induced by radiation, surgical management may have a role. PMID:26686486

  1. cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis

    OpenAIRE

    Luciano Lobo Gatti; Roger de Lábio; Luiz Carlos da Silva; Marília de Arruda Cardoso Smith; Spencer Luiz Marques Payão

    2006-01-01

    Helicobacter pylori is a spiral-shaped Gram-negative bacterium. It colonizes the gastric mucosa of humans and persists for decades if not treated. Helicobacter pylori infection affects more than half of the world's population and invariably results in chronic gastritis. The cagA gene is present in about 60 to 70% of H. pylori strains; it encodes a high-molecular-weight protein (120 to 140 kDa) and several investigators have noted a correlation between strains that possess cagA and the severit...

  2. Expression of matrix metalloproteinases 2 and 9 in human gastric cancer and superficial gastritis

    Institute of Scientific and Technical Information of China (English)

    Clara; Luz; Sampieri; Sol; de; la; Pea; Mariana; Ochoa-Lara; Roberto; Zenteno-Cuevas; Kenneth; León-Córdoba

    2010-01-01

    AIM:To assess expression of matrix metalloproteinases 2(MMP2)and MMP9 in gastric cancer,superficial gastritis and normal mucosa,and to measure metalloproteinase activity.METHODS:MMP2 and MMP9 mRNA expression was determined by quantitative real-time polymerase chain reaction.Normalization was carried out using three different factors.Proteins were analyzed by quantitative gelatin zymography(qGZ).RESULTS:18S ribosomal RNA(18SRNA)was very highly expressed,while hypoxanthine ribosyltransferase-1(HPRT-1)was mode...

  3. Q-Ulcer: un medicamento para el tratamiento de la gastritis en Pediatría

    Directory of Open Access Journals (Sweden)

    Juan A. Castillo Hernández

    2005-01-01

    Full Text Available El dolor abdominal recurrente afecta aproximadamente al 12 % de la población pediátrica mundial. La endoscopia con biopsia gástrica y prueba de ureasa han sugerido que este dolor se relaciona con gastritis nodular asociada a infección por Helicobacter pylori (Hp. Se realizó un estudio en 66 niños entre 7 y 15 años de edad y de ambos sexos, ingresados en 9 hospitales cubanos con el objetivo de evaluar el efecto del Q-Ulcer (subcitrato de bismuto coloidal y metronidazol en pacientes con diagnóstico endoscópico de gastritis crónica asociada a infección por Hp. Se realizó endoscopia, examen histológico y evaluación clínica antes de comenzar el tratamiento y 4 semanas después de haber finalizado. En treinta y cuatro de estos pacientes se erradicó el Hp con remisión de la gastritis. De los 28 pacientes restantes 14 se incluyeron en la categoría de mejorados y 14 en la de sin respuesta, debido a que el microorganismo se mantuvo positivo, aunque en menor densidad. Los eventos adversos se presentaron en aproximadamente la mitad de los niños y fundamentalmente, durante las dos primeras semanas de tratamiento en que la terapia era combinada. Por esta razón, no se puede precisar que fuera el Q-Ulcer el único responsable de la presencia de estos síntomas, ya que a partir de la tercera semana no se presentaron con la misma frecuencia. La terapia combinada de Q-Ulcer y metronidazol garantizó una apreciable mejoría clínica, endoscópica e histológica, a la vez que resultó segura en el tratamiento de niños portadores de gastritis.

  4. Medicinal Herbs Used in Pairs for Treatment of 98 Cases of Chronic Gastritis

    Institute of Scientific and Technical Information of China (English)

    夏建忠

    2004-01-01

    Objective: Chronic gastritis was treated with herbal pairs in order to reduce the side effects and raise the therapeutic effects. Method: The outpatients were randomly divided into a treatment group treated with herbal pairs and a control group treated with Banxia Xiexin Tang (Pinellia Decoction for Purging the Stomach-fire). Result: The total effective rate in the treatment group was 96%, higher than that in the control group (P<0.05). Conclusion: With the basic theory of traditional Chinese medicine as guiding principles, herbal pairs have two-way regulatory effects, that is, reducing the side effects and raising the therapeutic effects.

  5. Diffusion tensor analysis of corpus callosum in progressive supranuclear palsy

    Energy Technology Data Exchange (ETDEWEB)

    Ito, Shoichi; Makino, Takahiro; Shirai, Wakako; Hattori, Takamichi [Department of Neurology, Graduate School of Medicine, Chiba University (Japan)

    2008-11-15

    Progressive supranuclear palsy (PSP) is a neurodegenerative disease featuring parkinsonism, supranuclear ophthalmoplegia, dysphagia, and frontal lobe dysfunction. The corpus callosum which consists of many commissure fibers probably reflects cerebral cortical function. Several previous reports showed atrophy or diffusion abnormalities of anterior corpus callosum in PSP patients, but partitioning method used in these studies was based on data obtained in nonhuman primates. In this study, we performed a diffusion tensor analysis using a new partitioning method for the human corpus callosum. Seven consecutive patients with PSP were compared with 29 age-matched patients with Parkinson's Disease (PD) and 19 age-matched healthy control subjects. All subjects underwent diffusion tensor magnetic resonance imaging, and the corpus callosum was partitioned into five areas on the mid-sagittal plane according to a recently established topography of human corpus callosum (CC1-prefrontal area, CC2-premotor and supplementary motor area, CC3-motor area, CC4-sensory area, CC5-parietal, temporal, and occipital area). Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were measured in each area and differences between groups were analyzed. In the PSP group, FA values were significantly decreased in CC1 and CC2, and ADC values were significantly increased in CC1 and CC2. Receiver operating characteristic analysis showed excellent reliability of FA and ADC analyses of CC1 for differentiating PSP from PD. The anterior corpus callosum corresponding to the prefrontal, premotor, and supplementary motor cortices is affected in PSP patients. This analysis can be an additional test for further confirmation of the diagnosis of PSP.

  6. Diffusion tensor analysis of corpus callosum in progressive supranuclear palsy

    International Nuclear Information System (INIS)

    Progressive supranuclear palsy (PSP) is a neurodegenerative disease featuring parkinsonism, supranuclear ophthalmoplegia, dysphagia, and frontal lobe dysfunction. The corpus callosum which consists of many commissure fibers probably reflects cerebral cortical function. Several previous reports showed atrophy or diffusion abnormalities of anterior corpus callosum in PSP patients, but partitioning method used in these studies was based on data obtained in nonhuman primates. In this study, we performed a diffusion tensor analysis using a new partitioning method for the human corpus callosum. Seven consecutive patients with PSP were compared with 29 age-matched patients with Parkinson's Disease (PD) and 19 age-matched healthy control subjects. All subjects underwent diffusion tensor magnetic resonance imaging, and the corpus callosum was partitioned into five areas on the mid-sagittal plane according to a recently established topography of human corpus callosum (CC1-prefrontal area, CC2-premotor and supplementary motor area, CC3-motor area, CC4-sensory area, CC5-parietal, temporal, and occipital area). Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were measured in each area and differences between groups were analyzed. In the PSP group, FA values were significantly decreased in CC1 and CC2, and ADC values were significantly increased in CC1 and CC2. Receiver operating characteristic analysis showed excellent reliability of FA and ADC analyses of CC1 for differentiating PSP from PD. The anterior corpus callosum corresponding to the prefrontal, premotor, and supplementary motor cortices is affected in PSP patients. This analysis can be an additional test for further confirmation of the diagnosis of PSP

  7. A strong association between thyrotropin receptor-blocking antibody-positive atrophic autoimmune thyroiditis and HLA-DR8 and HLA-DQB1 0302 in Koreans

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Bo Youn; Chung, Jae Hoon; Lee, Hong Kyu; Koh, Chang-Soon; Lee, Jung-Bin (Seoul National Univ. College of Medicine, Seoul (Korea, Republic of)); Shong, Young Kee (Univ. of Ulsan College of Medicine Ulsan (Korea, Republic of)); Han, Hoon (Catholic Univ. Medical College, Seoul (Korea, Republic of)); Chang, Youn Bok (Hallym Univ. College of Medicine, Seoul (Korea, Republic of))

    1993-09-01

    The authors investigated whether the associations between HLA alleles of patients with autoimmune hypothyroidism varied according to the presence or absence of TSH receptor-blocking antibody (TRBab). They analyzed the HLA-A, -B, -C, and -DR antigens by serotyping and the DQA1 and DQB1 genes using both enzymatic DNA amplification and sequence-specific oligonucleotide hybridizations. The patient population consisted of 47 Korean patients with atrophic autoimmune thyroiditis and 62 patients with goitrous autoimmune thyroiditis. The antigen frequency of HLA-DR8 was significantly increased in 23 atrophic autoimmune thyroiditis patients that were positive for TSH binding inhibitor immunoglobulin (TBII) compared to 136 controls [52% vs. 16%; x[sup 2] = 13.1; Pc (corrected P value) = 0.003]. This relative risk was 5.7; the etiological fraction was 0.43. HLA-DQB1*0302 was also increased in patients with TBII-positive atrophic autoimmune thyroiditis (24% vs. 7%; x[sup 2] = 11.2; Pc = 0.012; relative risk = 4.4; etiological fraction = 0.19). No specific DR antigens or DQB1 alleles were increased in either TBII-negative atrophic autoimmune thyroidities or goitrous autoimmune thyroiditis. A significant decrease in the frequency of HLA-DR6 antigen was observed in both TBII-positive atrophic antoimmune thyroiditis (0% vs. 32%; x[sup 2] = 8.4; Pc = 0.03) and goitrous autoimmune thyroiditis (0% vs. 32%; x[sup 2] = 23.2; Pc < 0.001) patients. The frequency of the HLC-Cwl antigen was significantly increased in all patient groups. The authors conclude that TRBab-positive atrophic autoimmune thyroiditis is immunogenetically different from both goitrous autoimmune thyroiditis and TRBab-negative atrophic autoimmune thyroiditis. It is possible that HLA-DR8 and/or DQB1*0302 may be related to the susceptibility genes involved in the production of TRBab in Koreans. 32 refs., 5 tabs.

  8. Are atrophic long-bone nonunions associated with low-grade infections?

    Directory of Open Access Journals (Sweden)

    Dapunt U

    2015-12-01

    Full Text Available Ulrike Dapunt,1 Ole Spranger,2 Simone Gantz,1 Irene Burckhardt,3 Stefan Zimmermann,3 Gerhard Schmidmaier,2 Arash Moghaddam2 1Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, 2HTRG–Heidelberg Trauma Research Group, Trauma and Reconstructive Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital, 3Department for Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg, Germany Abstract: Impaired fracture healing, especially when associated with bacterial infection, is a severe complication following long-bone fractures and requires special treatment. Because standard diagnostic techniques might provide falsely negative results, we evaluated the sonication method for detection of bacteria on implants of patients with fracture nonunions. A total of 49 patients with a nonunion (group NU and, for comparison, 45 patients who had undergone routine removal of osteosynthetic material (group OM, were included in the study. Five different diagnostic methods (culture of tissue samples, culture of intraoperative swabs, histopathology of tissue samples, culture of sonication fluid, and 16S ribosomal DNA polymerase chain reaction of sonication fluid were compared and related to clinical data. Among the diagnostic tests, culture of sonication fluid demonstrated by far the highest detection rate of bacteria (57% in group NU, and rather unexpectedly 40% in group OM. Culture of sonication samples also revealed a broad spectrum of bacteria, in particular Propionibacterium spp. In conclusion, our results indicate that more bacteria can be detected on implants of patients with atrophic nonunions of long-bone fractures by means of the sonication procedure, which provides a valuable additional diagnostic tool to decide on a surgical procedure (eg, two-step procedure and to further specify antimicrobial therapy. Keywords: sonication, osteosynthetic material, osteomyelitis 

  9. What is the Optimal Treatment of Atrophic Scaphoid Non-Union?

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    Alper Cirakli

    2014-12-01

    Full Text Available Aim: To evaluate the efficacy of the treatment method of autogenous iliac wing or radius bone graft and fixation with screw applied to cases of scaphoid non-union. Material and Method: A retrospective evaluation was made of 89 cases between 2000 and 2014. Postoperative measurements were taken of both wrists%u2019 movement with a goniometer and muscle strength was assessed with a dynamometer. Fractures were evaluated radiologically according to the Herbert-Fisher System and the functional results according to the Herbert-Fisher Classification System and the Mayo Clinic Modified Wrist Scoring System. The data were input to the SPSS system and evaluated with the Shapiro-Wilk test. Results: Non-union were on the right side in 47 and the left side in 42 cases. The fracture was seen to be in the waist in 60 cases (67.5%, in the proximal third in 27 cases (30.3% and in the distal third in two cases (2.2%. The mean follow-up period was 16.4 months (range, 5-72 months. Definitive findings of union were observed in 71 cases. The mean time to union was 14.9 weeks (range, 8-40 weeks. Discussion: The grafting procedure applied is an invasive technique but if it is considered that there are negative effects of open surgery on the feeding of the scaphoid bone, then in the treatment of scaphoid non-union which is atrophic non-union, ultimately autogenous bone grafting and screw fixation is a safe and successful method and because of the pain created by an iliac wing graft, radius distal bone graft can be considered more appropriate.

  10. A multimodal corpus of speech to infant and adult listeners.

    Science.gov (United States)

    Johnson, Elizabeth K; Lahey, Mybeth; Ernestus, Mirjam; Cutler, Anne

    2013-12-01

    An audio and video corpus of speech addressed to 28 11-month-olds is described. The corpus allows comparisons between adult speech directed toward infants, familiar adults, and unfamiliar adult addressees as well as of caregivers' word teaching strategies across word classes. Summary data show that infant-directed speech differed more from speech to unfamiliar than familiar adults, that word teaching strategies for nominals versus verbs and adjectives differed, that mothers mostly addressed infants with multi-word utterances, and that infants' vocabulary size was unrelated to speech rate, but correlated positively with predominance of continuous caregiver speech (not of isolated words) in the input. PMID:25669300

  11. The Shona Corpus and the Problem of Tagging?

    Directory of Open Access Journals (Sweden)

    Emmanuel Chabata

    2011-10-01

    Full Text Available

    Abstract: In this paper the writer examines problems the African Languages Lexical (ALLEX Project (at present the African Languages Research Institute (ALRI? encountered while tagging the Shona corpus. The problems to be highlighted include general problems which apply to more than one language as well as problems peculiar to Shona. The paper was inspired by the challenges the writer encountered when he took part in building the Shona corpus. An analysis of the problems that most corpus builders face shows that more problems are likely to be encountered when dealing with spoken corpora than with written corpora. The paper demonstrates that tagging is an important component of corpus building as it makes it easier for a researcher to extract relevant data. To utilise the benefits of a tagged corpus, the tagging should be thorough and accurate. Wellinformed decisions form an integral part of the tagging process since the utility of a tagged corpus depends largely on the input of the tagging process. This paper shows the need to take the tagging process seriously.

    Keywords: ALLEX PROJECT, COMPUTER, CORPUS, ENCODING, FOREIGN WORD, LEMMATIZATION, LEXICOGRAPHY, MONITOR CORPUS, PART OF SPEECH, SCANNING, SHONA, SLANG, TAGGING, TRANSCRIPTION, WORD

    Opsomming: Die Shonakorpus en die probleem van etikettering, In hierdieartikel ondersoek die outeur probleme wat die African Languages Lexical (ALLEX Project (tansdie African Languages Research Institute (ALRI» teegekom het terwyl die Shonakorpus geetiketteeris. Die probleme wat bespreek word, sluit algemene probleme in wat van toepassing is opmeer as een taa, sowel as spesifieke probleme wat eie aan Shona is. Die artikel het sy ontstaan indie uitdagings wat die outeur teegekom het terwyl hy deel gehad het aan die opbou van die Shonakorpus.'n Ontieding van die probleme waarvoor die meeste korpusbouers te staan kom, toon datdaar waarskynlik meer probleme teegekom word wanneer daar met gesproke

  12. Quantitative analysis of mouse corpus callosum from electron microscopy images

    Directory of Open Access Journals (Sweden)

    Kathryn L. West

    2015-12-01

    Full Text Available This article provides morphometric analysis of 72 electron microscopy images from control (n=4 and hypomyelinated (n=2 mouse corpus callosum. Measures of axon diameter and g-ratio were tabulated across all brains from two regions of the corpus callosum and a non-linear relationship between axon diameter and g-ratio was observed. These data are related to the accompanying research article comparing multiple methods of measuring g-ratio entitled ‘A revised model for estimating g-ratio from MRI’ (West et al., NeuroImage, 2015.

  13. Normal Corpus Callosum Dimensions Measured by MRI

    International Nuclear Information System (INIS)

    As a result of measuring the size of corpus callosum in normal Korean people by using MRI, the following conclusions were obtained. 1. Maximum, minimum, and mean values by the region in whole subjects 1) Anteroposterior length amounted to the mean with 69.30 mm, the minimum with 50.70 mm, and the maximum with 80.40 mm. 2) Diameter of genu amounted to the mean with 11.93 mm, the minimum with 6.00 mm, and the maximum with 18.50 mm. 3) Diameter of mid body amounted to the mean with 7.00 mm, the minimum with 3.40 mm, and the maximum with 10.40 mm. 4) Diameter of narrowing portion amounted to the mean with 4.51 mm, the minimum with 0.80 mm, and the maximum with 9.50 mm. 5) Diameter of splenium amounted to the mean with 12.17 mm, the minimum with 6.90 mm, and the maximum with 17.20 mm. 2. Comparison by region according to the gender in the whole subjects 1) Anteroposterior length was bigger in men than in women, and showed the significant difference depending on gender. 2) Diameter of genu, diameter of mid body, and diameter of narrowing portion were bigger in men than in women, but there was no significant difference. 3) Diameter of splenium was bigger in men than in women, and showed the statistically significant difference. 3. Comparison by region according to the age in the whole subjects 1) Anteroposterior length was the biggest in the 50s at the age, and was smaller in heir 10s than other age levels. In addition, the significant difference was indicated depending on age. 2) Diameter of genu and diameter of mid body were the biggest in their 30s, and were smaller in the 60s than other age levels. And, the statistically significant difference was indicated. 3) Diameter of narrowing portion was the thickest in their 20s, and was thinner in their 60s than other age levels. And, the significant difference was indicated depending on age. 4) Diameter of splenium was the thickest in their 30s, and was thinner in their 10s than other age levels. And, the statistically

  14. Normal Corpus Callosum Dimensions Measured by MRI

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ham Gyum [Dept. of Radiological Technology, Ansan College, Ansan (Korea, Republic of)

    2008-09-15

    As a result of measuring the size of corpus callosum in normal Korean people by using MRI, the following conclusions were obtained. 1. Maximum, minimum, and mean values by the region in whole subjects 1) Anteroposterior length amounted to the mean with 69.30 mm, the minimum with 50.70 mm, and the maximum with 80.40 mm. 2) Diameter of genu amounted to the mean with 11.93 mm, the minimum with 6.00 mm, and the maximum with 18.50 mm. 3) Diameter of mid body amounted to the mean with 7.00 mm, the minimum with 3.40 mm, and the maximum with 10.40 mm. 4) Diameter of narrowing portion amounted to the mean with 4.51 mm, the minimum with 0.80 mm, and the maximum with 9.50 mm. 5) Diameter of splenium amounted to the mean with 12.17 mm, the minimum with 6.90 mm, and the maximum with 17.20 mm. 2. Comparison by region according to the gender in the whole subjects 1) Anteroposterior length was bigger in men than in women, and showed the significant difference depending on gender. 2) Diameter of genu, diameter of mid body, and diameter of narrowing portion were bigger in men than in women, but there was no significant difference. 3) Diameter of splenium was bigger in men than in women, and showed the statistically significant difference. 3. Comparison by region according to the age in the whole subjects 1) Anteroposterior length was the biggest in the 50s at the age, and was smaller in heir 10s than other age levels. In addition, the significant difference was indicated depending on age. 2) Diameter of genu and diameter of mid body were the biggest in their 30s, and were smaller in the 60s than other age levels. And, the statistically significant difference was indicated. 3) Diameter of narrowing portion was the thickest in their 20s, and was thinner in their 60s than other age levels. And, the significant difference was indicated depending on age. 4) Diameter of splenium was the thickest in their 30s, and was thinner in their 10s than other age levels. And, the statistically

  15. Eosinophil infiltration, gastric juice and serum eosinophil cationic protein levels in Helicobacter pylori-associated chronic gastritis and gastric ulcer

    Directory of Open Access Journals (Sweden)

    Yucel Ustundag

    1992-01-01

    Full Text Available INTRODUCTION: Helicobacter pylori is one of the main causes of gastroduodenal diseases, such as chronic gastritis and peptic ulcer. It has been shown that eosinophils increase in the stomach in H. pylori infection. Eosinophilic cationic protein (ECP is a cytotoxic molecule secreted by the activated eosinophils. However, there are no sufficient data about the role of ECP in H. pylori infection and its effect on ulcer development. In this study we investigated the gastric eosinophilic infiltration, gastric juice and serum ECP levels in patients with chronic gastritis and gastric ulcer associated with H. pylori.

  16. Expression of cytokeratins in Helicobacter pylori-associated chronic gastritis of adult patients infected with cagA + strains: An immunohistochemical study

    Institute of Scientific and Technical Information of China (English)

    Vera Todorovic; Aleksandra Sokic-Milutinovic; Neda Drndarevic; Marjan Micev; Olivera Mlitrovic; Ivan Nikolic; Thomas Wex; Tomica Milosavljevic; Peter Malfertheiner

    2006-01-01

    AIM: To investigate the expression of different cytokeratins (CKs) in gastric epithelium of adult patients with chronic gastritis infected with Helicobacter pylori(H pylori) cagA + strains.METHODS: The expression of CK 7, 8, 18, 19 and 20 was studied immunohistochemically in antral gastric biopsies of 84 patients. All the CKs were immunostained in cagA +H pylori gastritis (57 cases), non-Hpylori gastritis (17 cases) and normal gastric mucosa (10 cases).RESULTS: In cagA+ Hpylori gastritis, CK8 was expressed comparably to the normal antral mucosa from surface epithelium to deep glands. Distribution of CK18 and CK 19 was unchanged, i.e. transmucosal,but intensity of the expression was different in foveolar region in comparison to normal gastric mucosa. Cytokeratin 18 immunoreactivity was significantly higher in the foveolar epithelium of H pylori-positive gastritis compared to both Hpylori-negative gastritis and controls.On the contrary, decrease in CK19 immunoreactivity occurred in foveolar epithelium of H pylori-positive gastritis. In both normal and inflamed antral mucosa without H pylori infection, CK20 was expressed strongly/ moderately and homogenously in surface epithelium and upper foveolar region, but in H pylori-induced gastritis significant decrease of expression in foveolar region was noted. Generally, in both normal antral mucosa and H pylori-negative gastritis, expression of CK7 was not observed, while in about half cagA+ H pylori-infected patients, moderate focal CK7 immunoreactivity of the neck and coiled gland areas was registered, especially in areas with more severe inflammatory infiltrate.CONCLUSION: Alterations in expression of CK 7, 18,19 and 20 together with normal expression of CK8 occur in antral mucosa of H pylori-associated chronic gastritis in adult patients infected with cagA+ strains. Alterations in different cytokeratins expression might contribute to weakening of epithelial tight junctions observed in H pylori-infected gastric mucosa.

  17. A study of Helicobacter pylori -associated gastritis patterns in Iraq and their association with strain virulence

    Directory of Open Access Journals (Sweden)

    Hussein Nawfal

    2009-01-01

    Full Text Available Background/Aim: Helicobacter pylori ( H. pylori infection causes peptic ulceration and gastric adenocarcinoma. In Iraq, gastric cancer is rare. We investigated whether infected adults had the antral-predominant pattern of H. pylori -associated gastritis, which does not predispose to cancer. Materials and Methods: We evaluated histopathological changes by the Sydney scoring system in gastric biopsies taken from 30 H. pylori -infected adults and studied the correlation of these changes with the virulence factors. The Mann-Whitney test was used for the comparison of histopathological data. The presence or absence of each pathological index was evaluated with respect to the possession of virulence factors by the infecting H. pylori strain using the χ2 test. Results: Gastric lymphocyte infiltration was more prominent in the antrum ( P = 0.01. Neutrophil infiltration was mild and gastric mucosal atrophy was rare. No relationship was found between virulence factors and histopathological changes. Conclusions: The mild pathology and antral-predominant gastritis help explain the low cancer rate in Iraq.

  18. The Metabonomic Studies of Tongue Coating in H. pylori Positive Chronic Gastritis Patients

    Directory of Open Access Journals (Sweden)

    Xuan Liu

    2015-01-01

    Full Text Available In Traditional Chinese Medicine (TCM, tongue diagnosis (TD has been an important diagnostic method for the last 3000 years. Tongue coating can be used as a very sensitive marker to determine the progress of chronic gastritis. Therefore, the scientific, qualitative, and quantitative study for the pathophysiologic basis of tongue coating (TC emerged as a major direction for the objective research of TD. In our current report, we used GC/MS technology to determine the potential changes of metabolites and identify special metabolic biomarkers in the TC of H. pylori infected chronic gastritis patients. Four discriminative metabolites were identified by GC/MS between the TC of H. pylori infection (G+H and without H. pylori infection (G-H patients: ethylene, cephaloridine, γ-aminobutyric acid, and 5-pyroglutamic acid, indicating that changes in amino acid metabolism are possibly involved in the formation of TC, and the amino acid metabolites are part of the material components of TC in G+H patients.

  19. Russell body gastritis/duodenitis: a case series and description of immunoglobulin light chain restriction.

    Science.gov (United States)

    Zhang, Hejun; Jin, Zhu; Cui, Rongli

    2014-10-01

    Russell body esophago-gastro-duodenitis is an unusual form of chronic inflammation, with only 22 cases being reported in PubMed. However, the prevalence and clinical significance remain unknown. This report describes the clinico-pathological characteristics of nine cases of Russell body gastritis (RBG) and one case of Russell body duodentitis (RBD), with nonspecific endoscopic appearance. The Mott cells (plasma cells with Russell bodies) showed κ light chain restriction in eight gastritis cases and λ light chain restriction in the duodentitis case, and there were no histological features that suggested lymphoma. Thus, a diagnosis of monoclonal RBG/RBD was made. Helicobacter pylori infection was found in 55.6% of RBG cases and in the RBD case. And, the clinical follow-up evaluations were uneventful. This report is the first study to describe this benign disease entity with monoclonality on a large-scale basis. In addition, the monoclonality of Mott cells cannot be used as evidence of an existing neoplastic lesion, and taken together, these findings may indicate a reactive process. PMID:25001185

  20. A histopathologic analysis of chronic inflammatory infiltrate in patients of h. pylori associated chronic gastritis

    International Nuclear Information System (INIS)

    To determine the relationship between H. pylori density with severity of chronic inflammatory infiltrate. Study Design: A cross-sectional study. Place and Duration of Study: The study was carried out in the Department of Pathology (Histopathology), Army Medical College, National University of Sciences and Technology (NUST) Islamabad, from Nov 2011 to Nov 2012. Methodology: Gastric antral biopsies of H. pylori associated chronic gastritis were included in the study. Demographic characteristics and relevant clinical information were collected. First hundred biopsies of H. pylori associated chronic gastritis were assessed for density of H. pylori and chronic inflammatory infiltrate. istopathological features like lymphoid aggregates, ulcer slough, superficial epithelial damage, dysplasia and nuclear reactive changes were simply assessed in case of their presence or absence. Results: A significant moderate positive correlation was found between grades of H. pylori and chronic inflammatory infiltrate (rs= 0.636). Insignificant correlation was found with lymphoid aggregates, superficial epithelial damage, dysplasia and nuclear reactive changes. Conclusion: In conclusion this study corroborated the determination of histopathological parameters and depicted that, the greater the density of H. pylori infection, the greater the degrees of chronic inflammatory infiltrate. (author)

  1. A classification scheme for annotating speech acts in a business email corpus

    OpenAIRE

    De Felice, R.; Darby, J; Fisher, A.; Peplow, D.

    2013-01-01

    This paper reports on the process of manual annotation of speech acts in a corpus of business emails, in the context of the PROBE project (PRagmatics of Business English). The project aims to bring together corpus, computational, and theoretical linguistics by drawing on the insights made available by the annotated corpus. The corpus data sheds light on the linguistic and discourse structures of speech act use in business email communication. This enhanced linguistic descrip...

  2. Study of corpus callosum in experimental hydrocephalic wistar rats

    Directory of Open Access Journals (Sweden)

    Lopes Luiza da Silva

    2003-01-01

    Full Text Available PURPOSE: Hydrocephalus causes countless cerebral damages, especially on the structures around the ventricles. Hydrocephalic children present deficiencies in the nonverbal skills more than in the verbal skills, and not always revertible with an early treatment. As the corpus callosum has an important role in the nonverbal acquisition it is possible that the injuries in this structure are responsible for the cognitive dysfunctions of these children. This present study tries to establish the alterations caused by hydrocephalus on the corpus callosum of developing Wistar rats, induced by intracisternal injection of kaolin. METHODS : Seven, fourteen and twenty one days after the injection, the animals were killed, and the corpus callosum was dissected and prepared for the study of the axonal fibers. RESULTS AND CONCLUSION: The seven-day old rats in hydrocephalus development presented a delay in myelination in relation to the control rats. With the fourteen-day old rats in hydrocephalus development the corpus callosum showed a recovery of myelin, but with the twenty one-day old rats in hydrocephalus development the axonal fibers were damaged and reduced in number.

  3. Väärtused Theognise luulekogumikus Corpus Theognideum / Martin Suuroja

    Index Scriptorium Estoniae

    Suuroja, Martin

    2002-01-01

    Bibl. lk. 1413-1414. Kokkuvõte "Values in Theognis' collection of poems Corpus Theognideum", lk. 1537-1538. Theognise (552-549) luulekogumiku põhjal analüüsitakse Kreeka ühiskonnas domineerinud väärtusi

  4. A corpus of preposition supersenses in English web reviews

    OpenAIRE

    Schneider, Nathan; Hwang, Jena D; Srikumar, Vivek; Green, Meredith; Conger, Kathryn; O'Gorman, Tim; Palmer, Martha

    2016-01-01

    We present the first corpus annotated with preposition supersenses, unlexicalized categories for semantic functions that can be marked by English prepositions (Schneider et al., 2015). That scheme improves upon its predecessors to better facilitate comprehensive manual annotation. Moreover, unlike the previous schemes, the preposition supersenses are organized hierarchically. Our data will be publicly released on the web upon publication.

  5. Corpus callosum arteriovenous malformation with persistent trigeminal artery.

    Science.gov (United States)

    Mohanty, Chandan B; Devi, B Indira; Somanna, Sampath; Bhat, Dhananjaya I; Dawn, Rose

    2011-12-01

    A 13-year-old boy presented with an intracerebral haematoma secondary to a large corpus callosal arteriovenous malformation (AVM) with an associated persistent trigeminal artery, and was treated with Gamma-Knife Radiosurgery for the AVM. This report discusses the embryological basis, radiological features and various classifications of this rare vascular anomaly. PMID:21501055

  6. Combining text clustering and retrieval for corpus adaptation

    Science.gov (United States)

    He, Feng; Ding, Xiaoqing

    2007-01-01

    The application-relevant text data are very useful in various natural language applications. Using them can achieve significantly better performance for vocabulary selection, language modeling, which are widely employed in automatic speech recognition, intelligent input method etc. In some situations, however, the relevant data is hard to collect. Thus, the scarcity of application-relevant training text brings difficulty upon these natural language processing. In this paper, only using a small set of application specific text, by combining unsupervised text clustering and text retrieval techniques, the proposed approach can find the relevant text from unorganized large scale corpus, thereby, adapt training corpus towards the application area of interest. We use the performance of n-gram statistical language model, which is trained from the text retrieved and test on the application-specific text, to evaluate the relevance of the text acquired, accordingly, to validate the effectiveness of our corpus adaptation approach. The language models trained from the ranked text bundles present well discriminated perplexities on the application-specific text. The preliminary experiments on short message text and unorganized large corpus demonstrate the performance of the proposed methods.

  7. A Corpus-based Analysis of English Noun Suffixes

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    This paper provides a brief analysis of English suffixes. First, make a classification of the English noun suffixes etymologically; then, obtain the frequencies of each English noun suffixes in sub-corpus FR88 and WSJ88, and last draw a conclusion based on the statistics. That is from the word origins we can see its influences on English vocabulary.

  8. Corpus callosum atrophy in patients with mild Alzheimer's disease

    DEFF Research Database (Denmark)

    Frederiksen, Kristian Steen; Garde, Ellen; Skimminge, Arnold;

    2011-01-01

    Several studies have found atrophy of the corpus callosum (CC) in patients with Alzheimer's disease (AD). However, it remains unclear whether callosal atrophy is already present in the early stages of AD, and to what extent it may be associated with other structural changes in the brain, such as...

  9. EuroGOV: Engineering a Multilingual Web Corpus

    NARCIS (Netherlands)

    B. Sigurbjörnsson; J. Kamps; M. de Rijke

    2005-01-01

    EuroGOV is a multilingual web corpus that was created to serve as the document collection for WebCLEF, the CLEF 2005 web retrieval task. EuroGOV is a collection of web pages crawled from the European Union portal, European Union member state governmental web sites, and Russian government web sites.

  10. Semantic Associations in Business English: A Corpus-Based Analysis

    Science.gov (United States)

    Nelson, Mike

    2006-01-01

    This paper examines the semantic associations of words found in the business lexical environment by using a one-million word corpus of both spoken and written Business English. The key method of analysis is that of semantic prosody or semantic association; the notion that words associate with collocates that are themselves related, often either…

  11. Audio description and corpus analysis of popular music

    NARCIS (Netherlands)

    Van Balen, J.M.H.

    2016-01-01

    In the field of sound and music computing, only a handful of studies are concerned with the pursuit of new musical knowledge. There is a substantial body of corpus analysis research focused on new musical insight, but almost all of it deals with symbolic data: scores, chords or manual annotations. I

  12. A Corpus-Based Comparative Study of "Learn" and "Acquire"

    Science.gov (United States)

    Yang, Bei

    2016-01-01

    As an important yet intricate linguistic feature in English language, synonymy poses a great challenge for second language learners. Using the 100 million-word British National Corpus (BNC) as data and the software Sketch Engine (SkE) as an analyzing tool, this article compares the usage of "learn" and "acquire" used in natural…

  13. Corpus-based collocation research targeted at Japanese language learners

    Directory of Open Access Journals (Sweden)

    Irena SRDANOVIĆ

    2014-12-01

    Full Text Available This paper discusses corpus-based research on collocations, introduces various tools for querying and extracting Japanese collocations and presents an analysis of Japanese collocations using language corpora and related tools. First, major corpus query tools such as Sketch Engine, NINJAL-NLP, Natsume, Chunagon, which can be used by learners and teachers of Japanese language, are briefly described. Focus then shifts to adjectival and nominal collocates and the resource "Collocation data of adjectives and nouns" which consists of adjective headwords and their nominal collocates extracted from two large corpora, BCCWJ and JpTenTen: 500 adjectives and 9,218 collocate nouns, and 500 adjectives and 23,220 collocate nouns from each corpus respectively. Finally, it is shown that corpus-based resources can be used in the creation of reference materials for learners of the Japanese language. The benefits of empirical research into collocations are also shown by comparing the obtained results with collocations in textbooks for Japanese as foreign language.

  14. Data modelling in corpus linguistics : How low may we go?

    NARCIS (Netherlands)

    van Velzen, Marjolein H.; Nanetti, Luca; de Deyn, Peter P.

    2014-01-01

    Corpus linguistics allows researchers to process millions of words. However, the more words we analyse, i.e., the more data we acquire, the more urgent the call for correct data interpretation becomes. In recent years, a number of studies saw the light attempting to profile some prolific authors' li

  15. Using the national corpus of russian language in metaphor studies

    OpenAIRE

    Plisetskaya A. D.

    2010-01-01

    The article describes using The National Corpus of Russian Language for metaphor studies. We analyzed the metaphor 'val'utny koridor' (currency corridor) looking into the context of its usage in the media and found out some interesting collocations dealing with the origin of the metaphor. The research can be useful for students learning how to use the national language database.

  16. Parenting, corpus callosum, and executive function in preschool children.

    Science.gov (United States)

    Kok, Rianne; Lucassen, Nicole; Bakermans-Kranenburg, Marian J; van IJzendoorn, Marinus H; Ghassabian, Akhgar; Roza, Sabine J; Govaert, Paul; Jaddoe, Vincent W; Hofman, Albert; Verhulst, Frank C; Tiemeier, Henning

    2014-01-01

    In this longitudinal population-based study (N = 544), we investigated whether early parenting and corpus callosum length predict child executive function abilities at 4 years of age. The length of the corpus callosum in infancy was measured using postnatal cranial ultrasounds at 6 weeks of age. At 3 years, two aspects of parenting were observed: maternal sensitivity during a teaching task and maternal discipline style during a discipline task. Parents rated executive function problems at 4 years of age in five domains of inhibition, shifting, emotional control, working memory, and planning/organizing, using the Behavior Rating Inventory of Executive Function-Preschool Version. Maternal sensitivity predicted less executive function problems at preschool age. A significant interaction was found between corpus callosum length in infancy and maternal use of positive discipline to determine child inhibition problems: The association between a relatively shorter corpus callosum in infancy and child inhibition problems was reduced in children who experienced more positive discipline. Our results point to the buffering potential of positive parenting for children with biological vulnerability. PMID:24028215

  17. Sexual dimorphism of the human corpus callosum: Digital morphometric study

    Directory of Open Access Journals (Sweden)

    Spasojević Goran

    2006-01-01

    Full Text Available Background/Aim. Changes in the morphology and the size of the corpus callosum, are related to various pathological conditions. An analysis of these changes requires data about sexual dimorphism of the corpus callosum, which we tried to obtain in our study. We also investigated the method of digital morphometry and compared the obtained results with the results of other authors obtained by magnetic resonance imaging or by planimetry. Methods. A morphological research included 34 human brains (cadavers of both sexes − 19 female and 15 male aged 26−72 years. By digital morphometry using an AutoCAD software we performed measurements in the corpus callosum: the length (L, width in the half of its length (WW’, length of its cortical margin (LCM, area and perimeter of the anterior and posterior callosal segments, as well as the area and perimeter of the corpus callosum section area. The investigated parameters were analyzed and compared between the females and males. Results. There was not a statistically significant difference between the males and females in the investigated parameters of the corpus callosum (t test; p > 0.05, including the mean values of the two most important parameters, the surface of its midsagittal section area (males 654.11 mm2; females 677.40 mm2 and of its perimeter (males 19.61 cm; females 19.72 cm. The results obtained by digital morphometry were in the range of the results of other authors obtained by magnetic resonance and by planimetry. However, the value of Pearson coefficient of linear correlation between the section surface area and perimeter of the corpus callosum in the males was highly significant (rxy = 0.6943, p < 0.01, while in the females this value was statistically insignificant. Conclusion. Digital morphometry is accurate method in encephalometric investigations. Our results suggest that the problem of sexual dimorphism of the corpus callosum is very complex, because the identical variables (section

  18. Motivating College Students' Learning English for Specific Purposes Courses through Corpus Building

    Science.gov (United States)

    Wu, Lin-Fang

    2014-01-01

    This study was conducted to determine how to motivate technical college students to learn English for specific purposes (ESP) courses through corpus building and enhance their language proficiency during the coursework for their majors. This study explores corpus building skills, how to simplify ESP courses by corpus building for English as second…

  19. A Primary Ovarian Pregnancy with a Contralateral Ruptured Corpus Luteum: A Case Report

    OpenAIRE

    Ziyauddin, Farah; Khan, Tamkin; Rafat, Dalia; Aziz, Meher; Haider, Nazima

    2012-01-01

    A primary ovarian pregnancy is one of the rarest varieties of ectopic pregnancies. The conditions which are most commonly confused with an ovarian pregnancy are, a ruptured corpus luteal cyst, a haemorrhagic corpus luteum and a ruptured endometriotic cyst. This case presents the clinical and the histological findings of a ruptured ovarian pregnancy, along with a ruptured corpus luteal cyst in the contralateral ovary.

  20. Clinical endocrinological studies on the function of human corpus luteum

    International Nuclear Information System (INIS)

    Plasma progesterone (P) and estradiol-17β (E2) were measured with the radioimmunoassay (RIA), and the human corpus luteum function detected. They are investigated endocrinologically. The investigation is divided into three sections. The first section deals with a study on the function of corpus luteum menstruations. Plasma level of P was 12.6 +- 3.83 ng/ml and that of E2 was 18.9 +- 61.7 pg/ml during mid-luteal phase. Plasma levels of P during menstrual cycle in infertile woman whose BBT(basal body temperature) high phase were 12.1 +- 4.56 ng/ml for 13 days or more, and 6.82 +- 2.14 ng/ml for 11 days. Those indicate a significant difference. However, in the case of E2, there is no significant difference. Interrelation of administration was not recognized between hCG(human chorionic gonadotropin) 2,000, 3,000 and 5,000 IU. The second section deals with the function of corpus luteum graviditatis. There was no significant difference of plasma levels between P and E2 during conceptual cycles. The most active period of the corpus luteum function may be 5 - 6 weeks of gravidity, and the life of the function is considered to be about 9 - 10 weeks. The final section deals with the steroides dynamics under hCG administration for threatened abortion cases in early pregnancy. Administration of hCG up to 20,000 IU a day of normal pregnancy and threatened abortion showed remarkable increase of levels of P and E2. Exogenous hCG up to 20,000 IU a day is supposed to have no luteotropic effect on corpus luteum graviditatis. (Iwakiri, K.)