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Sample records for atorvastatin-treated healthy men

  1. Healthy Eating for Men

    Science.gov (United States)

    ... For Parents For Men For Women For Seniors Healthy Eating for Men Published June 23, 2014 Print Email ... June 2014 Tags Health Wellness Nutrition Healthy Aging Healthy Eating Preventing Illness Your Health and Your Weight Heart ...

  2. Health-related physical fitness in healthy untrained men

    DEFF Research Database (Denmark)

    Milanović, Zoran; Pantelić, Saša; Sporiš, Goran;

    2015-01-01

    The purpose of this study was to determine the effects of recreational soccer (SOC) compared to moderate-intensity continuous running (RUN) on all health-related physical fitness components in healthy untrained men. Sixty-nine participants were recruited and randomly assigned to one of three grou...

  3. Decreases in Human Semen Quality with Age Among Healthy Men

    Energy Technology Data Exchange (ETDEWEB)

    Eskenazi, B.; Wyrobek, A.J.; Kidd, S.A.; Moore, L.; Young, S.S.; Moore, D.

    2001-12-01

    The objective of this report is to characterize the associations between age and semen quality among healthy active men after controlling for identified covariates. Ninety-seven healthy, nonsmoking men between 22 and 80 years without known fertility problems who worked for or retired from a large research laboratory. There was a gradual decrease in all semen parameters from 22-80 years of age. After adjusting for covariates, volume decreased 0.03 ml per year (p = 0.001); sperm concentration decreased 2.5% per year (p = 0.005); total count decreased 3.6% per year of age (p < 0.001); motility decreased 0.7% per year (P < 0.001); progressive motility decreased 3.1% per year (p < 0.001); and total progressively motile sperm decreased 4.8% per year (p < 0.001). In a group of healthy active men, semen volume, sperm concentration, total sperm count, and sperm motility decrease continuously between 22-80 years of age, with no evidence of a threshold.

  4. Testosterone and sexual desire in healthy women and men.

    Science.gov (United States)

    van Anders, Sari M

    2012-12-01

    Sexual desire is typically higher in men than in women, with testosterone (T) thought to account for this difference as well as within-sex variation in desire in both women and men. However, few studies have incorporated both hormonal and social or psychological factors in studies of sexual desire. The present study addressed how three psychological domains (sexual-relational, stress-mood, body-embodiment) were related to links between T and sexual desire in healthy adults and whether dyadic and solitary desire showed associations with T. Participants (n = 196) were recruited as part of the Partnering, Physiology, and Health study, which had 105 men and 91 women who completed questionnaires and provided saliva for cortisol and T assays. T was positively linked to solitary desire in women, with masturbation frequency influencing this link. In contrast, T was negatively correlated with dyadic desire in women, but only when cortisol and perceived social stress were controlled. Replicating past findings, no significant correlations between T and desire in men were apparent, but these analyses showed that the null association remained even when psychological and confound variables were controlled. Men showed higher desire than women, but masturbation frequency rather than T influenced this difference. Results were discussed in terms of challenges to assumptions of clear links between T and desire, gendered approaches to T, and the unitarity of desire. PMID:22552705

  5. Bioelectrical Impedance Vector Analysis and Muscular Fitness in Healthy Men

    Directory of Open Access Journals (Sweden)

    Fernando Rodríguez-Rodríguez

    2016-07-01

    Full Text Available Muscle strength can define the general muscular fitness (MF measurable through hand-grip strength (HG, which is a factor that relates to the health of people of different ages. In this study we evaluated the muscle strength together with a bioimpedance electric analysis in 223 healthy Colombian adult subjects. The bioelectrical impedance vector analysis (BIVA was conducted to determine the resistance (R, reactance (Xc and phase angle (PhA. We classified the subjects into three groups (for tertiles, obtaining lower values of R and Xc in subjects with lower HG, plus a high correlation between PhA and HG. An increase in the level of PhA is associated with a high level of MF in a sample of healthy Latin American adult men. The BIVA’s parameters and PhA are a potentially effective preventive measure to be integrated into routine screening in the clinical setting.

  6. Bioelectrical Impedance Vector Analysis and Muscular Fitness in Healthy Men.

    Science.gov (United States)

    Rodríguez-Rodríguez, Fernando; Cristi-Montero, Carlos; González-Ruíz, Katherine; Correa-Bautista, Jorge Enrique; Ramírez-Vélez, Robinson

    2016-01-01

    Muscle strength can define the general muscular fitness (MF) measurable through hand-grip strength (HG), which is a factor that relates to the health of people of different ages. In this study we evaluated the muscle strength together with a bioimpedance electric analysis in 223 healthy Colombian adult subjects. The bioelectrical impedance vector analysis (BIVA) was conducted to determine the resistance (R), reactance (Xc) and phase angle (PhA). We classified the subjects into three groups (for tertiles), obtaining lower values of R and Xc in subjects with lower HG, plus a high correlation between PhA and HG. An increase in the level of PhA is associated with a high level of MF in a sample of healthy Latin American adult men. The BIVA's parameters and PhA are a potentially effective preventive measure to be integrated into routine screening in the clinical setting. PMID:27384579

  7. Testosterone and reward prediction-errors in healthy men and men with schizophrenia.

    Science.gov (United States)

    Morris, R W; Purves-Tyson, T D; Weickert, C Shannon; Rothmond, D; Lenroot, R; Weickert, T W

    2015-11-01

    Sex hormones impact reward processing, which is dysfunctional in schizophrenia; however, the degree to which testosterone levels relate to reward-related brain activity in healthy men and the extent to which this relationship may be altered in men with schizophrenia has not been determined. We used functional magnetic resonance imaging (fMRI) to measure neural responses in the striatum during reward prediction-errors and hormone assays to measure testosterone and prolactin in serum. To determine if testosterone can have a direct effect on dopamine neurons, we also localized and measured androgen receptors in human midbrain with immunohistochemistry and quantitative PCR. We found correlations between testosterone and prediction-error related activity in the ventral striatum of healthy men, but not in men with schizophrenia, such that testosterone increased the size of positive and negative prediction-error related activity in a valence-specific manner. We also identified midbrain dopamine neurons that were androgen receptor immunoreactive, and found that androgen receptor (AR) mRNA was positively correlated with tyrosine hydroxylase (TH) mRNA in human male substantia nigra. The results suggest that sex steroid receptors can potentially influence midbrain dopamine biosynthesis, and higher levels of serum testosterone are linked to better discrimination of motivationally-relevant signals in the ventral striatum, putatively by modulation of the dopamine biosynthesis pathway via AR ligand binding. However, the normal relationship between serum testosterone and ventral striatum activity during reward learning appears to be disrupted in schizophrenia. PMID:26232868

  8. Effects of Music on Cardiovascular Responses in Men with Essential Hypertension Compared with Healthy Men Based on Introversion and Extraversion

    OpenAIRE

    Hossein Namdar; Mohammadreza Taban Sadeghi; Hassan Sabourimoghaddam; Babak Sadeghi; Davoud Ezzati

    2014-01-01

    Introduction: The present research investigated the effects of two different types of music on cardiovascular responses in essential hypertensive men in comparison with healthy men based on introversion and extraversion. Methods: One hundred and thirteen hypertensive men referred to Madani Heart Hospital in Tabriz completed the NEO-FFI Questionnaire and after obtaining acceptable scores were classified in four groups: introvert patients, extravert patients, introvert healthy subjects, and ext...

  9. Cardiovascular effects of intravenous ghrelin infusion in healthy young men

    DEFF Research Database (Denmark)

    Vestergaard, Esben Thyssen; Andersen, Niels Holmark; Hansen, Troels Krarup;

    2007-01-01

    Ghrelin infusion improves cardiac function in patients suffering from cardiac failure, and bolus administration of ghrelin increases cardiac output in healthy subjects. The cardiovascular effects of more continuous intravenous ghrelin exposure remain to be studied. We therefore studied the cardio......Ghrelin infusion improves cardiac function in patients suffering from cardiac failure, and bolus administration of ghrelin increases cardiac output in healthy subjects. The cardiovascular effects of more continuous intravenous ghrelin exposure remain to be studied. We therefore studied...... the cardiovascular effects of a constant infusion of human ghrelin at a rate of 5 pmol/kg per minute for 180 min. Fifteen healthy, young (aged 23.2 ± 0.5 yr), normal-weight (23.0 ± 0.4 kg/m2) men volunteered in a randomized double-blind, placebo-controlled crossover study. With the subjects remaining fasting, peak...... myocardial systolic velocity S′, tissue tracking TT, left ventricular ejection fraction EF, and endothelium-dependent flow-mediated vasodilatation were measured. Ghrelin infusion increased S′ 9% (P = 0.002) and TT 10% (P

  10. GH administration and discontinuation in healthy elderly men

    DEFF Research Database (Denmark)

    Lange, K H; Isaksson, F; Rasmussen, M H;

    2001-01-01

    GH administration results in increased lean body mass (LBM), decreased fat mass (FM) and increased energy expenditure (EE). GH therapy may therefore have potential benefits, especially in the elderly, who are known to have decreased function of the GH/IGF-I axis. Several studies have focused on...... effects of GH administration in the elderly in the last decade. However, very limited information is available regarding changes in body composition and EE upon GH discontinuation in the elderly. The present study therefore investigated the effects of 12 weeks of GH administration and subsequent...... discontinuation on body composition, resting oxygen uptake (VO2), resting heart rate (HR) and GH related serum markers in healthy elderly men....

  11. High-resolution Sonographic Measurements of Lower Extremity Bursae in Chinese Healthy Young Men

    Directory of Open Access Journals (Sweden)

    Yong-Yan Gao

    2016-01-01

    Conclusions: Using HR-US imaging, we were able to analyze lower extremity bursae with high detection rates in healthy young men. The normal ranges of lower extremity bursa dimensions in healthy young men measured by HR-US in this study could be used as reference values for evaluation of bursa abnormalities in the lower extremity.

  12. Impaired Glucose Tolerance in Healthy Men Treated with St. John's Wort

    DEFF Research Database (Denmark)

    Stage, Tore Bjerregaard; Damkier, Per; Christensen, Mette Marie Hougaard;

    2016-01-01

    The purpose of this study was to examine if the over-the-counter herbal medicinal plant St. John's wort affects glucose tolerance in healthy men. To do this, we included 10 healthy men who were examined by a 2-hr oral glucose tolerance test on three occasions; A: Baseline, B: After 21 days...

  13. Technology of making healthy and correction of build of men of the first mature age

    Directory of Open Access Journals (Sweden)

    Stroganov S.V.

    2010-07-01

    Full Text Available Directions of search of ways of making healthy of population of mature age are considered. In an experiment 30 men took part 21-35 years. The men of experimental group conducted training on the basis of 4th of the monthly program of correction and making healthy. There was statistically meaningful divergence in the capacity of men of experimental group by comparison to the men of control group. Also in the subjective estimation of own build, feel for a day, at the end of workweek and after training. Employment on the developed technology induced the men of experimental group a greater measure to give up harmful habits.

  14. Independent association between glycated hemoglobin and arterial stiffness in healthy men

    OpenAIRE

    Noh, Jin‐Won; Kim, Eun‐Jung; Seo, Hyun‐Ju; Kim, Soo Geun

    2015-01-01

    Abstract Aims/Introduction Many studies have reported that high levels of glycated hemoglobin (HbA1c) are strongly associated with an increased risk of cardiovascular disease. Many researchers have not studied the association of HbA1c with various subclinical atherosclerosis phenotypes. We evaluated the impact of HbA1c on arterial stiffness and atherosclerosis in healthy Korean healthy men. Materials and Methods The study population included healthy adult men who participated in health check‐...

  15. St. John's wort impairs glucose tolerance by reducing insulin response in healthy men

    DEFF Research Database (Denmark)

    Stage, Tore Bjerregaard; Damkier, Per; Christensen, Mette Marie Hougaard; Nielsen, Lene Buch-Krogh; Højlund, Kurt; Brøsen, Kim

    The purpose of this study was to examine if the over-the-counter herbal medicinal plant St. John's wort affects glucose tolerance in healthy men. To do this, we included 10 healthy men who were examined by a 2-hr oral glucose tolerance test on three occasions; A: Baseline, B: After 21 days...... men. The unregulated use of this over-the-counter drug might be a risk factor for impaired glucose tolerance and type 2 diabetes. This article is protected by copyright. All rights reserved....

  16. Comparing of Early Maladaptive Schemas between Healthy and Addicted Men

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    Vida Razavi

    2012-09-01

    Full Text Available Background: Early maladaptive schemas are self-defeating emotional and cognitive patterns that develop early in life and repeat during the life cycle. They may cause a lot of psychological disorders including anxiety, depression, and drug abuse. Regarding to the importance of the prevention and treatment of addiction and regarding to obscurity of schemas about addiction, we compared the schemas of addicted and non-addicted men. Materials and Methods: In this cross-sectional study, 205 addicted and non-addicted men were selected in the city of Kerman through cluster sampling. To collect information, a questionnaire with acceptable validity and reliability consisting of demographic information and early maladaptive schemas was used. Data analysis was performed with SPSS-17 software.Results: Totally, 96 addicted and 106 non-addicted men with a mean age of 33.3±9.8 years participated in the study. There were significant differences between early maladaptive schemas in two groups of addicted and non-addicted men (p=0.001. Logistic regression analysis showed that enmeshment, emotional deprivation, and vulnerability to harm or illness maladaptive schemas can predict addiction (p=0.001.Conclusion: According to this study, the most important schemas for addicted men are emotional deprivation, self-sacrifice, emotional inhibition, unrelenting standards, entitlement, insufficient self-control/self-discipline, and disconnection as well as enmeshment, vulnerability to harm or illness, and emotional deprivation predictor schemas that require special notion from related institutions and addiction therapist for addiction rehabilitation and prevention.

  17. Serum Phospholipid Docosahexaenoic Acid Is Inversely Associated with Arterial Stiffness in Metabolically Healthy Men

    Science.gov (United States)

    Lee, Mi-Hyang; Kwon, Nayeon; Yoon, So Ra

    2016-01-01

    We hypothesized that lower proportion of serum phospholipid docosahexaenoic acid (DHA) is inversely associated with increased cardiovascular risk and vascular function in metabolically healthy men. To elucidate it, we first compared serum phospholipid free fatty acid (FA) compositions and cardiovascular risk parameters between healthy men (n = 499) and male patients with coronary artery disease (CAD, n = 111) (30-69 years) without metabolic syndrome, and then further-analyzed the association of serum phospholipid DHA composition with arterial stiffness expressed by brachial-ankle pulse wave velocity (ba-PWV) in metabolically healthy men. Basic parameters, lipid profiles, fasting glycemic status, adiponectin, high sensitivity C-reactive protein (hs-CRP) and LDL particle size, and serum phospholipid FA compositions were significantly different between the two subject groups. Serum phospholipid DHA was highly correlated with most of long-chain FAs. Metabolically healthy men were subdivided into tertile groups according to serum phospholipid DHA proportion: lower ( 3.235%). Fasting glucose, insulin resistance, hs-CRP and ba-PWVs were significantly higher and adiponectin and LDL particle size were significantly lower in the lower-DHA group than the higher-DHA group after adjusted for confounding factors. In metabolically healthy men, multiple stepwise regression analysis revealed that serum phospholipid DHA mainly contributed to arterial stiffness (β′-coefficients = -0.127, p = 0.006) together with age, systolic blood pressure, triglyceride (r = 0.548, p = 0.023). Lower proportion of serum phospholipid DHA was associated with increased cardiovascular risk and arterial stiffness in metabolically healthy men. It suggests that maintaining higher proportion of serum phospholipid DHA may be beneficial for reducing cardiovascular risk including arterial stiffness in metabolically healthy men. PMID:27482523

  18. Comparing of Early Maladaptive Schemas between Healthy and Addicted Men

    OpenAIRE

    Vida Razavi; Ali Soltaninezhad; Afsoon Rafiee

    2012-01-01

    Background: Early maladaptive schemas are self-defeating emotional and cognitive patterns that develop early in life and repeat during the life cycle. They may cause a lot of psychological disorders including anxiety, depression, and drug abuse. Regarding to the importance of the prevention and treatment of addiction and regarding to obscurity of schemas about addiction, we compared the schemas of addicted and non-addicted men. Materials and Methods: In this cross-sectional study, 205 addicte...

  19. Seminal gold content in healthy fertile men in India

    OpenAIRE

    Jain, Vinod; Rai, Anurag; Misra, Samir; Singh, K.M.

    2010-01-01

    Objective: Since centuries Ayurveda, mentions the role of gold in the treatment of male infertility ‘Swarna Bhasma’ (Ash of gold) has been used with good results by Ayurvedic practitioners in the treatment of infertility. Hence, a study was planned to estimate gold in whole semen by atomic absorption spectrophotometry. Materials and Methods: Whole semen from 11 healthy males of proved fertility from Lucknow (India) was analyzed for gold content by Atomic Absorption spectrophotometry at wavele...

  20. Effects of Music on Cardiovascular Responses in Men with Essential Hypertension Compared with Healthy Men Based on Introversion and Extraversion

    Directory of Open Access Journals (Sweden)

    Hossein Namdar

    2014-10-01

    Full Text Available Introduction: The present research investigated the effects of two different types of music on cardiovascular responses in essential hypertensive men in comparison with healthy men based on introversion and extraversion. Methods: One hundred and thirteen hypertensive men referred to Madani Heart Hospital in Tabriz completed the NEO-FFI Questionnaire and after obtaining acceptable scores were classified in four groups: introvert patients, extravert patients, introvert healthy subjects, and extravert healthy subjects (each group with 25 samples with age range 31-50. Baseline blood pressure and heart rate of each subject was recorded without any stimulus. Then subjects were exposed to slow-beat music and blood pressure and heart rate were recorded. After15 minute break, and a little cognitive task for distraction, subjects were exposed to fast-beat music and blood pressure and heart rate were recorded again. Results: Multivariate analysis of covariance (MANCOVA test showed that extravert patient subjects obtained greater reduction in systolic blood pressure and heart rate after presenting slow-beat music compared with introvert patients (P= 0.035, and P= 0.033 respectively. And extravert healthy subjects obtained greater reduction in heart rate after presenting slow-beat music compared with introvert healthy subjects (P= 0.036. However, there are no significant differences between introvert and extravert groups in systolic and diastolic blood pressure and heart rate after presenting fast-beat music. Conclusion: Based on our results, introvert subjects experience negative emotions more than extravert subjects and negative emotions cause less change in blood pressure in these subjects compared with extravert subjects.

  1. Phthalate Excretion Pattern and Testicular Function: A Study of 881 Healthy Danish Men

    OpenAIRE

    Joensen, Ulla Nordström; Frederiksen, Hanne; Jensen, Martin Blomberg; Lauritsen, Mette Petri; Olesen, Inge Ahlmann; Lassen, Tina Harmer; Andersson, Anna-Maria; Jørgensen, Niels

    2012-01-01

    Background: In animals, some phthalates impair male reproductive development and function. Epidemiological studies have reported inconsistent evidence of associations between phthalates and markers of human testicular function. Objectives: We aimed to provide estimates of the effects of phthalate exposure on reproductive hormone levels and semen quality in healthy men. Methods: A total of 881 men gave urine, serum, and semen samples. Serum levels of testosterone, estradiol (E2), sex hormone-b...

  2. Training intensities for aerobic exercise determined on untrained healthy men.

    Directory of Open Access Journals (Sweden)

    Miura,Mochiyoshi

    1995-04-01

    Full Text Available The purpose of this study was to determine the aerobic training intensity from the maximal and submaximal running exercise in 21 untrained adult men. To accomplish this, we evaluated the relationship between physiological (oxygen intake and heart rate and physical parameters (running speed of training intensity, and determined the training intensity at the submaximal exercise. Oxygen intake and heart rate were measured by a treadmill test. The maximal oxygen intake (VO2 max, and the aerobic threshold (AerT and anaerobic threshold (AT were measured to determine respiratory gas exchange. Running capacity was measured by a 12-min running and treadmill test. For the maximal exercise, there was a significant correlation (r = 0.88, P < 0.01 between VO2 max and 12-min running distance (speed. In addition, the oxygen intake and heart rate at AerT and AT in the submaximal exercise were linearly correlated with running speed. Three levels of training intensity at the submaximal exercise were termed: light, moderate, and heavy. Since AerT was the lower limit intensity and AT was the upper limit, we took the middle of their values as the moderate intensity. The end point for the determination of the training intensity at the submaximal exercise was estimated to be 85% VO2 max and 180 beats.min-1.

  3. Comparison of total and compartmental gastric emptying and antral motility between healthy men and women

    Energy Technology Data Exchange (ETDEWEB)

    Bennink, R.; Van den Maegdenbergh, V.; Roo, M. de; Mortelmans, L. [Department of Nuclear Medicine, UZ KU Leuven (Belgium); Peeters, M.; Geypens, B.; Rutgeerts, P. [Department of Gastroenterology, UZ KU Leuven (Belgium)

    1998-09-01

    There is increasing evidence of gender-related differences in gastric emptying. The purpose of this study was first, to confirm the difference in gastric emptying for both solid and liquid test meals between healthy men and women, and secondly, to investigate the origin of this difference by studying regional gastric emptying and antral motility. A standard gastric emptying test with additional compartmental (proximal and distal) evaluation and dynamic imaging of the antrum was performed in 20 healthy women studied during the first 10 days of the menstrual cycle, and in 31 healthy age-matched men. In concordance with previous reports, women had a longer half-emptying time for solids as compared to men (86.2{+-}5.1 vs 52.2{+-}2.9 min, P<0.05). In our observations this seemed to be related to a significantly prolonged lag phase and a significant decrease in terminal slope. Dynamical antral scintigraphy did not show a significant difference. The distribution of the test meal within the stomach (proximal vs distal) showed more early proximal retention in women as compared to men. The terminal slope of the distal somach was significantly lower in women. We did not observe a significant difference in gastric emptying of the liquid test meal between men and women. Gastric emptying of solids is significantly slower in healthy women as compared to men. These findings emphasise the importance of using different normal values for clinical and research purposes in gastric emptying scintigraphy in men and women. The difference could not be explained by antral motility alone. Increased proximal retention and a lower terminal emptying rate in women are observations to be further investigated. (orig.) With 5 figs., 2 tabs., 36 refs.

  4. Four days of muscle disuse impairs single fiber contractile function in young and old healthy men

    DEFF Research Database (Denmark)

    Hvid, Lars Grøndahl; Suetta, Charlotte Arneboe; Aagaard, Per;

    2013-01-01

    The purpose of the study was to investigate the effects of 4 days of disuse (knee brace) on contractile function of isolated vastus lateralis fibers (n=486) from 11 young (24.3+/-0.9 yrs) and 11 old (67.2+/-1.0 yrs) healthy men having comparable levels of physical activity. Prior to disuse single...

  5. Safety Measures of L-Carnitine L-Tartrate Supplementation in Healthy Men.

    Science.gov (United States)

    Rubin, Martyn R.; Volek, Jeff S.; Gomez, Ana L.; Ratamess, Nicholas A.; French, Duncan N.; Sharman, Matthew J.; Kraemer, William J.

    2001-01-01

    Examined the effects of ingesting the dietary supplement L- CARNIPURE on liver and renal function and blood hematology among healthy men. Analysis of blood samples indicated that there were no statistically significant differences between the L-CARNIPURE and placebo conditions for any variables examined, suggesting there are no safety concerns…

  6. Postprandial lipemia in men with metabolic syndrome, hypertensives and healthy subjects

    Directory of Open Access Journals (Sweden)

    Iraklianou Stella A

    2005-09-01

    Full Text Available Abstract Background The metabolic syndrome (MetS, as well as postprandial hypertriglyceridemia, is associated with coronary heart disease. This study aimed to evaluate the postprandial lipemia after oral fat tolerance test (OFTT in subjects with MetS and compare them to hypertensive (HTN and healthy subjects. Results OFTT was given to 33 men with MetS (defined by the Adult Treatment Panel III, 17 HTN and 14 healthy men. The MetS group was further divided according to fasting triglycerides (TG into TG ≥ 150 [MetS+TG, (n = 22] or The postprandial response was significantly higher in MetS compared to HTN and healthy men [AUC (SD in mg/dl/h; 2534 ± 1016 vs. 1620 ± 494 and 1019 ± 280, respectively, p ≤ 0.001]. The TG levels were increased significantly in MetS+TG compared to MetS-TG subjects at 4 (p = 0.022, 6 (p Conclusion Fasting TG concentration is the main determinant of postprandial lipemia. However, an exaggeration of TG postprandialy was found in normotriglyceridemic MetS and HTN compared to healthy subjects. This suggests that intervention to lower fasting TG levels should be recommended in MetS subjects.

  7. Acute dietary nitrate supplementation does not augment submaximal forearm exercise hyperemia in healthy young men

    OpenAIRE

    Kim, Jin-Kwang; Moore, David J.; Maurer, David G.; Kim-Shapiro, Daniel B.; Basu, Swati; Flanagan, Michael P.; Skulas-Ray, Ann C.; Kris-Etherton, Penny; Proctor, David N.

    2014-01-01

    Despite the popularity of dietary nitrate supplementation and the growing evidence base of its potential ergogenic and vascular health benefits, there is no direct information about its effects on exercising limb blood flow in humans. We hypothesized that acute dietary nitrate supplementation from beetroot juice would augment the increases in forearm blood flow, as well as the progressive dilation of the brachial artery, during graded handgrip exercise in healthy young men. In a randomized, d...

  8. Intranasal Insulin Enhances Postprandial Thermogenesis and Lowers Postprandial Serum Insulin Levels in Healthy Men

    OpenAIRE

    Benedict, Christian; Brede, Swantje; Schiöth, Helgi B.; Lehnert, Hendrik; Schultes, Bernd; Born, Jan; Hallschmid, Manfred

    2010-01-01

    OBJECTIVE Animal studies indicate a prominent role of brain insulin signaling in the regulation of peripheral energy metabolism. We determined the effect of intranasal insulin, which directly targets the brain, on glucose metabolism and energy expenditure in humans. RESEARCH DESIGN AND METHODS In a double-blind, placebo-controlled, balanced within-subject comparison, 19 healthy normal-weight men (18–26 years old) were intranasally administered 160 IU human insulin after an overnight fast. Ene...

  9. Bicycle Riding: Impact on Lower Urinary Tract Symptoms and Erectile Function in Healthy Men

    OpenAIRE

    Baek, Seok; Lee, Sun Young; Kim, Jong Min; Shin, Esther; Kam, Sin; Jung, Hee Chang

    2011-01-01

    Purpose Recently, reports in the mass media have implicated that bicycle riding increases the risk of erectile dysfunction and prostatic diseases. So, we evaluate the impact of bicycle riding on erectile function and lower urinary tract symptoms (LUTS) in healthy general men. Methods From 26 June 2010 to 20 July 2010, we investigate degree of LUTS (voiding and storage symptoms), using International Continence Society-male Questionnaire (ICS-mQ) and erectile function using International Index ...

  10. Effects of a Rubus coreanus Miquel supplement on plasma antioxidant capacity in healthy Korean men

    OpenAIRE

    Lee, Ji Eun; Park, Eunkyo; Lee, Jung Eun; Auh, Joong Hyuck; Choi, Hyung-Kyoon; Lee, Jaehwi; Cho, SooMuk; Kim, Jung-Hyun

    2011-01-01

    Korean raspberry, Rubus coreanus Miquel (RCM), contains high concentrations of phenolic compounds, which prevent oxidative stress. To determine the effect of RCM on antioxidant capacity in humans, we assessed in vivo lipid oxidation and antioxidant enzyme activities from plasma in 15 healthy men. The subjects ingested 30 g of freeze-dried RCM daily for 4 weeks. Blood was taken at baseline and at the end of the study to determine blood lipid profiles, fasting plasma glucose, liver function, li...

  11. Physiological limits of physical performance of healthy men [Fiziologicheskij predel fizicheskoj rabotosposobnosti zdorovykh muzhchin

    OpenAIRE

    Noreiko S.B.

    2011-01-01

    A comprehensive functional examination of 30 healthy men aged 21 to 50 years. Moderate physical activity up to 100-125 watts was accompanied by significant increase in vital capacity and forced vital capacity. This is indicative of the activation of functional reserves of the respiratory system during the recovery period after exercise. Set a limit to the power of exercise performed, achieved a majority surveyed (125-150 watts). This indicator is recommended as a standard test, which indicate...

  12. Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women.

    Science.gov (United States)

    Fleg, J L; O'Connor, F; Gerstenblith, G; Becker, L C; Clulow, J; Schulman, S P; Lakatta, E G

    1995-03-01

    To examine whether age differentially modifies the physiological response to exercise in men and women, we performed gated radionuclide ventriculography with measurement of left ventricular volumes at rest and during peak upright cycle exercise in 200 rigorously screened healthy sedentary volunteers (121 men and 79 women) aged 22-86 yr from the Baltimore Longitudinal Study of Aging. At rest in the sitting position, age-associated declines in heart rate (HR) and increases in systolic blood pressure occurred in both sexes. Whereas resting cardiac index (CI) and total systemic vascular resistance (TSVR) in men did not vary with age, in women resting CI decreased 16% and TSVR increased 46% over the six-decade age span. Men, but not women, demonstrated an age-associated increase of approximately 20% in sitting end-diastolic volume index (EDVI), end-systolic volume index (ESVI), and stroke volume index over this age span. Peak cycle work rate declined with age approximately 40% in both sexes, but at any age it was greater in men than in women even after normalization for body weight. At peak effort, ejection fraction (EF), HR, and CI were reduced similarly with age while ESVI and TSVR were increased in both sexes; EDVI increased 35% with age and stroke work index (SWI) rose 19% in men, but neither was related to age in women; and stroke volume index did not vary with age in either sex. When hemodynamics were expressed as the change from rest to peak effort as an index of cardiovascular reserve function, both sexes demonstrated age-associated increases in EDVI and ESVI and reductions in EF, HR, and CI. However, the exercise-induced reduction in ESVI and the increases in EF, CI, and SWI from rest were greater in men than in women. Thus, age and gender each have a significant impact on the cardiac response to exhaustive upright cycle exercise. PMID:7775334

  13. Aerobic capacity reference data in 3816 healthy men and women 20-90 years.

    Directory of Open Access Journals (Sweden)

    Henrik Loe

    Full Text Available PURPOSE: To provide a large reference material on aerobic fitness and exercise physiology data in a healthy population of Norwegian men and women aged 20-90 years. METHODS: Maximal and sub maximal levels of VO2, heart rate, oxygen pulse, and rating of perceived exertion (Borg scale: 6-20 were measured in 1929 men and 1881 women during treadmill running. RESULTS: The highest VO2max and maximal heart rate among men and women were observed in the youngest age group (20-29 years and was 54.4±8.4 mL·kg(-1·min(-1 and 43.0±7.7 mL·kg(-1·min(-1 (sex differences, p<0.001 and 196±10 beats·min(-1 and 194±9 beats·min(-1 (sex differences, p<0.05, respectively, with a subsequent reduction of approximately 3.5 mL·kg(-1·min(-1 and 6 beats·min(-1 per decade. The highest oxygen pulses were observed in the 3 youngest age groups (20-29 years, 30-39 years, 40-49 years among men and women; 22.3 mL·beat(-1±3.6 and 14.7 mL·beat(-1±2.7 (sex differences, p<0.001, respectively, with no significant difference between these age groups. After the age of 50 we observed an 8% reduction per decade among both sexes. Borg scores appear to give a good estimate of the relative exercise intensity, although observing a slightly different relationship than reported in previous reference material from small populations. CONCLUSION: This is the largest European reference material of objectively measured parameters of aerobic fitness and exercise-physiology in healthy men and women aged 20-90 years, forming the basis for an easily accessible, valid and understandable tool for improved training prescription in healthy men and women.

  14. Dysanapsis and the resistive work of breathing during exercise in healthy men and women.

    Science.gov (United States)

    Dominelli, Paolo B; Molgat-Seon, Yannick; Bingham, Derek; Swartz, Philippa M; Road, Jeremy D; Foster, Glen E; Sheel, A William

    2015-11-15

    We asked if the higher work of breathing (Wb) during exercise in women compared with men is explained by biological sex. We created a statistical model that accounts for both the viscoelastic and the resistive components of the total Wb and independently compares the effects of biological sex. We applied the model to esophageal pressure-derived Wb values obtained during an incremental cycle test to exhaustion. Subjects were healthy men (n = 17) and women (n = 18) with a range of maximal aerobic capacities (V̇o2 max range: men = 40-68 and women = 39-60 ml·kg(-1)·min(-1)). We also calculated the dysanapsis ratio using measures of lung recoil and forced expiratory flow as index of airway caliber. By applying the model we found that the differences in the total Wb during exercise in women are due to a higher resistive Wb rather than viscoelastic Wb. We also found that the higher resistive Wb is independently explained by biological sex. To account for the known effect of lung volumes on the dysanapsis ratio we compared the sexes with an analysis of covariance procedures and found that when vital capacity was accounted for the adjusted mean dysanapsis ratio is statistically lower in women (0.17 vs. 0.25 arbitrary units; P human airways, which result in significant male-female differences in the Wb during exercise in healthy subjects. PMID:26359483

  15. Relation Between Change in Renal Function and Cardiovascular Outcomes in Atorvastatin-Treated Patients (from the Treating to New Targets [TNT] Study).

    Science.gov (United States)

    Shepherd, James; Breazna, Andrei; Deedwania, Prakash C; LaRosa, John C; Wenger, Nanette K; Messig, Michael; Wilson, Daniel J

    2016-04-15

    Statins may have nephroprotective as well as cardioprotective effects in patients with cardiovascular disease. In the Treating to New Targets (TNT) study (NCT00327691), patients with coronary heart disease (CHD) were randomized to atorvastatin 10 or 80 mg/day and followed for 4.9 years. The relation between intrastudy change in estimated glomerular filtration rate (eGFR) from baseline and the risk of major cardiovascular events (MCVEs, defined as CHD death, nonfatal non-procedure-related myocardial infarction, resuscitated cardiac arrest, or fatal or nonfatal stroke) was assessed among 9,500 patients stratified by renal function: improving (change in eGFR more than +2 ml/min/1.73 m(2)), stable (-2 to +2 ml/min/1.73 m(2)), and worsening (less than -2 ml/min/1.73 m(2)). Compared with patients with worsening renal function (1,479 patients, 15.6%), the rate of MCVEs was 28% lower in patients with stable renal function (2,241 patients, 23.6%) (hazard ratio [HR] 0.72; 95% confidence interval [CI] 0.60 to 0.87; p = 0.0005) and 64% lower in patients with improving renal function (5,780 patients, 60.8%; HR 0.36; 95% CI 0.30 to 0.43; p atorvastatin 10 mg and 3.3% with atorvastatin 80 mg. In conclusion, intrastudy stabilization or increase in eGFR in atorvastatin-treated patients with CHD from the TNT study was associated with a reduced rate of MCVEs. Statin-treated CHD patients with progressive renal impairment are at high risk for future cardiovascular events. PMID:26940556

  16. Effects of an outdoor bicycle-based intervention in healthy rural Indian men with normal and low birth weight

    DEFF Research Database (Denmark)

    Madsen, Camilla; Mogensen, P; Thomas, N;

    2015-01-01

    outdoor exercise intervention on body composition, insulin secretion and action in young men born with LBW and NBW in rural India. A total of 61 LBW and 56 NBW healthy young men were recruited into the study. The individuals were instructed to perform outdoor bicycle exercise training for 45 min every day...

  17. Low density lipoprotein subclasses and response to a low-fat diet in healthy men

    Energy Technology Data Exchange (ETDEWEB)

    Krauss, R.M.; Dreon, D.M. [Lawrence Berkeley Lab., CA (United States). Life Sciences Div.

    1994-11-01

    Lipid and lipoprotein response to reduced dietary fat intake was investigated in relation to differences in distribution of LDL subclasses among 105 healthy men consuming high-fat (46%) and low-fat (24%) diets in random order for six weeks each. On high-fat, 87 subjects had predominantly large, buoyant LDL as measured by gradient gel electrophoresis and confirmed by analytic ultracentrifugation (pattern A), while the remainder had primarily smaller, denser LDL (pattern B). On low-fat, 36 men changed from pattern A to B. Compared with the 51 men in the stable A group, men in the stable B group (n = 18) had a three-fold greater reduction in LDL cholesterol and significantly greater reductions in plasma apoB and mass of intermediate (LDL II) and small (LDL III) LDL subtractions measured by analytic ultracentrifugation. In both stable A and change groups, reductions in LDL-cholesterol were not accompanied by reduced plasma apoB, consistent with the observation of a shift in LDL particle mass from larger, lipid-enriched (LDL I and II) to smaller, lipid-depleted (LDL III and IV) subfractions, without significant change in particle number. Genetic and environmental factors influencing LDL subclass distributions thus may also contribute substantially to interindividual variation in response to a low-fat diet.

  18. Demographic variability indicators of somatically healthy men from different administrative and territorial regions of Ukraine

    Directory of Open Access Journals (Sweden)

    Mishalov Volodymyr

    2016-06-01

    Full Text Available Our work has revealed a rather low level of similarity in regard to the finger dermatoglyphics of somatically healthy men, 19-35 years old, between Ukraine’s north and west, north and south, center and west, center and south, as well as the palmar dermatoglyphics between central regions and the east, center and west, center and south. The obtained finger/palmar dermatoglyphics did not differentiate administrative-territorial local groups of men between the north and the center, south and west (quantitative characteristics; or palmar – between the north and west, north and east, south and west, south and east, north and center. The differences between the administrative and territorial division of dermatoglyphic signs are a reflection of the historical and cultural differences induced by migration, as well as the intensive process of mixing, in addition to the isolation of particular groups.

  19. Bicycle Riding: Impact on Lower Urinary Tract Symptoms and Erectile Function in Healthy Men

    Science.gov (United States)

    Baek, Seok; Lee, Sun Young; Kim, Jong Min; Shin, Esther; Kam, Sin

    2011-01-01

    Purpose Recently, reports in the mass media have implicated that bicycle riding increases the risk of erectile dysfunction and prostatic diseases. So, we evaluate the impact of bicycle riding on erectile function and lower urinary tract symptoms (LUTS) in healthy general men. Methods From 26 June 2010 to 20 July 2010, we investigate degree of LUTS (voiding and storage symptoms), using International Continence Society-male Questionnaire (ICS-mQ) and erectile function using International Index of Erectile Function-5 Questionnaire (IIEF-5) in 5 work places (personnel of public office, hospital, university, etc.) of which bicycle riding club members were doing active club activities. Respondents, who participated in club activities for 6 months and longer, were classified as the bicycle club (142 men; age, 44.02±8.56). Ones who do not ride bicycles were classified as the control group (83 men; age, 42.13±7.85). People who were having the history of urological and other chronic diseases (diabetes, vascular disease, heart disease, etc) were excluded from both groups. Results Bicycle club is not significantly associated with increased prevalence of LUTS (bicycle club, 2.1 to 57.7% control, 4.8 to 73.5%) and erectile dysfunction (bicycle club, 46.1% control, 55.4%). The total mean score (storage/voiding/erectile function) of bicycle club (13.93±1.95/11.14±3.49/20.46±5.30) were not significantly different from control (14.35±2.49/11.52±3.38/20.40±4.07) (P=0.190 to 0.968). Conclusions These results suggested that bicycle riding as exercise or hobby has no negative effect on LUTS and erectile function in healthy general men, although this research data were limited to the questionnaire analysis. PMID:21811700

  20. Acute dietary nitrate supplementation does not augment submaximal forearm exercise hyperemia in healthy young men.

    Science.gov (United States)

    Kim, Jin-Kwang; Moore, David J; Maurer, David G; Kim-Shapiro, Daniel B; Basu, Swati; Flanagan, Michael P; Skulas-Ray, Ann C; Kris-Etherton, Penny; Proctor, David N

    2015-02-01

    Despite the popularity of dietary nitrate supplementation and the growing evidence base of its potential ergogenic and vascular health benefits, there is no direct information about its effects on exercising limb blood flow in humans. We hypothesized that acute dietary nitrate supplementation from beetroot juice would augment the increases in forearm blood flow, as well as the progressive dilation of the brachial artery, during graded handgrip exercise in healthy young men. In a randomized, double-blind, placebo-controlled crossover study, 12 young (22 ± 2 years) healthy men consumed a beetroot juice (140 mL Beet-It Sport, James White Juice Company) that provided 12.9 mmol (0.8 g) of nitrate or placebo (nitrate-depleted Beet-It Sport) on 2 study visits. At 3 h postconsumption, brachial artery diameter, flow, and blood velocity were measured (Doppler ultrasound) at rest and during 6 exercise intensities. Nitrate supplementation raised plasma nitrate (19.5-fold) and nitrite (1.6-fold) concentrations, and lowered resting arterial pulse wave velocity (PWV) versus placebo (all p < 0.05), indicating absorption, conversion, and a biological effect of this supplement. The supplement-associated lowering of PWV was also negatively correlated with plasma nitrite (r = -0.72, p = 0.0127). Despite these systemic effects, nitrate supplementation had no effect on brachial artery diameter, flow, or shear rates at rest (all p ≥ 0.28) or during any exercise workload (all p ≥ 0.18). These findings suggest that acute dietary nitrate supplementation favorably modifies arterial PWV, but does not augment blood flow or brachial artery vasodilation during nonfatiguing forearm exercise in healthy young men. PMID:25536008

  1. Abscess Formation after Septic Arthritis in the Sternoclavicular Joint of Two Healthy Men

    DEFF Research Database (Denmark)

    Henriksen, Jeppe; Tang, Mariann; Hjortdal, Vibeke

    2015-01-01

    Abscess formation after septic arthritis in the sternoclavicular joint is a rare phenomenon in healthy people without immune suppression, intravenous drug abuse, or diabetes. Here we report two cases with formation of abscess in two middle-aged men, with no relevant comorbidities and no obvious...... sites of infection. The abscesses were both treated surgically with debridement followed by negative pressure wound therapy and antibiotics. The cases differ in diagnostic procedures and delay of diagnosis and broach the issues of handling a rare disease....

  2. Sweet taste perception not altered after acute sleep deprivation in healthy young men

    OpenAIRE

    Hogenkamp, P S; E. Nilsson; Chapman, C.D.; Cedernaes, J.; Vogel, H.; Dickson, S. L.; Broman, J-E; Schiöth, H.B.; Benedict, C

    2013-01-01

    Background We hypothesized that acutely sleep-deprived participants would rate ascending concentrations of sucrose as more intense and pleasant, than they would do after one night of normal sleep. Such a finding would offer a potential mechanism through which acute sleep loss could promote overeating in humans. Method A total of 16 healthy normal-weight men participated in 2 conditions: sleep (permitted between 22:30 and 06:30 h) and total sleep deprivation (TSD) respectively. On the morning ...

  3. Effects of age and physical activity on the autonomic control of heart rate in healthy men

    OpenAIRE

    R.C. Melo; M.D.B. Santos; Silva, E.; R.J. Quitério; Moreno, M. A.; Reis, M. S.; I.A. Verzola; de Oliveira, L.; L.E.B. Martins; L. Gallo-Junior; A.M. Catai

    2005-01-01

    The effects of the aging process and an active life-style on the autonomic control of heart rate (HR) were investigated in nine young sedentary (YS, 23 ± 2.4 years), 16 young active (YA, 22 ± 2.1 years), 8 older sedentary (OS, 63 ± 2.4 years) and 8 older active (OA, 61 ± 1.1 years) healthy men. Electrocardiogram was continuously recorded for 15 min at rest and for 4 min in the deep breathing test, with a breath rate of 5 to 6 cycles/min in the supine position. Resting HR and RR intervals were...

  4. Short Hypoxia Does not Affect Plasma Leptin in Healthy Men under Euglycemic Clamp Conditions

    Directory of Open Access Journals (Sweden)

    Andre Schmoller

    2009-01-01

    Full Text Available Leptin is involved in the endocrine control of energy expenditure and body weight regulation. Previous studies emphasize a relationship between hypoxic states and leptin concentrations. The aim of this study was to investigate the effects of acute hypoxia on leptin concentrations in healthy subjects. We examined 14 healthy men. Hypoxic conditions were induced by decreasing oxygen saturation to 75% for 30 minutes. Plasma leptin concentrations were determined at baseline, after 3 hours of euglycemic clamping, during hypoxia, and repeatedly the following 2.5 hours thereafter. Our results show an increase of plasma leptin concentrations in the course of 6 hours of hyperinsulinemic-euglycemic clamping which may reflect diurnal rhythmicity. Notwithstanding, there was no difference between levels of leptin in the hypoxic and the normoxic condition (=.2. Since we did not find any significant changes in leptin responses upon hypoxia, plasma leptin levels do not seem to be affected by short hypoxic episodes of moderate degree.

  5. Endothelial dysfunction in young healthy men is associated with aspirin resistance.

    Science.gov (United States)

    Doroszko, Adrian; Szahidewicz-Krupska, Ewa; Janus, Agnieszka; Jakubowski, Maciej; Turek, Aleksandra; Ilnicka, Paulina; Szuba, Andrzej; Mazur, Grzegorz; Derkacz, Arkadiusz

    2015-01-01

    The aim of this study was to investigate the relation between endothelial dysfunction and aspirin response in a young healthy population (102 men aged 18-40). Initial concentrations of the NO pathway metabolites (ADMA, l-arginine, SDMA), cardiovascular risk markers, oxidative stress markers (MDA, thiol index), sICAM1, sVCAM1, PAI-1, sE-selectin, sP-selectin, VEGF, thromboxane B2, 6-keto-PGF1α and arachidonate-induced platelet aggregation (to separate aspirin resistant from sensitive group) were measured. Flow-mediated-vasodilation (FMD) was measured before and after intravenous infusion of 16.0 g of l-arginine. Measurements were repeated following aspirin administration (75 mg/24 h) for 4 days. Both groups were homogenous regarding demographic and biochemical characteristics reflecting cardiovascular risk. Aspirin resistant subjects were characterized by lower baseline FMD and higher FMD following aspirin and l-arginine treatment, as compared to aspirin sensitive control. MDA and nitrotyrosine were greater, whereas thiol index was lower in aspirin resistant men. The sICAM1, sVCAM1, PAI-1, sE-selectin, sP-selectin and VEGF levels were similar in the analyzed groups. Thromboxane in aspirin resistant subjects was greater both at baseline and following aspirin therapy. However, a significant decrease following aspirin treatment was present in both groups. Aspirin resistance in young men is associated with endothelial dysfunction, which could be due to oxidative stress resulting from lipid peroxidation. PMID:25697550

  6. EFFECTS OF SLEEP DEPRIVATION ON WHOLE NIGHT POLYSOMNOGRAPHY IN HEALTHY YOUNG MEN

    Institute of Scientific and Technical Information of China (English)

    XIAO Ze-ping; CHEN Xing-shi; WANG Ji-jun; ZHANG Ming-dao; WANG Hong-xing; HU Zhen-yu; LU Ying-zhi; ZHANG Zai-fu; GAN Jing-li; LOU Fei-ying; CHEN Chong; ZHANG Tian-hong; FAN Qing

    2009-01-01

    Objective To assess the effects of sleep deprivation (SD) on the whole night polysomnography (PSG) in healthy young men.Methods The whole night PSG was recorded by using Neurofax-1518K (Nihon Kohden, Japan) system before and after 38 h of SD among 15 healthy male subjects.Results Compared with PSG before SD, post-SD PSG showed significantly shortened sleep latency (before SD: 19.7±9.3, after SD: 5.6±7.3, P<0.05), decreased stage 1 (S1) non-rapid eye movement (NREM) sleep [before SD: (9.2±1.9)%, after SD: (4.0±1.4)%, P<0.05], and increased stage 4 (S4) NREM sleep [before SD: (10.3±3.7)%, after SD: (26.2±4.3)%, P<0.01].Conclusion During post-SD sleep, the proportion of S4 NREM sleep was increased as compensation in healthy male. In addition, SD was proved to affect electrophysiological brain activities in normal people.

  7. Similar Reference Intervals for Total Testosterone in Healthy Young and Elderly Men. Results from the Odense Androgen Study

    DEFF Research Database (Denmark)

    Nielsen, Morten Frost Munk; Wraae, K; Nielsen, Torben Leo; Hougaard, D; Brixen, K; Hagen, C; Andersen, Marianne

    2013-01-01

    CONTEXT: Aging in men is associated with changes in levels of sex hormones. OBJECTIVE: To evaluate differences in sex hormones in young and elderly men and the significance of comorbidity and fat mass on sex hormones in elderly men. DESIGN: Cross-sectional. PATIENTS: 783 men aged 20-29 years and...... 600 men aged 60-74 years randomly recruited from the background population. MEASUREMENTS: Sex hormones and SHBG were measured, and reference intervals were determined in healthy individuals in both groups and in elderly men stratified according to whether they were obese or lean (waist......-circumference ≥102cm). RESULTS: Sex hormones were lower and SHBG higher in elderly men compared to the young cohort. Lower cut-offs for TT in healthy, young and elderly men were similar (Lower cut-off (95%CI): Young: 11.7 (11.2-12.1) vs. elderly: 11.2 (10.3-12.1) nmol/l), but lower and higher cut-offs of BT and FT...

  8. Executive function on the 16-day of bed rest in young healthy men

    Science.gov (United States)

    Ishizaki, Yuko; Fukuoka, Hideoki; Tanaka, Hidetaka; Ishizaki, Tatsuro; Fujii, Yuri; Hattori-Uchida, Yuko; Nakamura, Minako; Ohkawa, Kaoru; Kobayashi, Hodaka; Taniuchi, Shoichiro; Kaneko, Kazunari

    2009-05-01

    Microgravity due to prolonged bed rest may cause changes in cerebral circulation, which is related to brain function. We evaluate the effect of simulated microgravity due to a 6° head-down tilt bed rest experiment on executive function among 12 healthy young men. Four kinds of psychoneurological tests—the table tapping test, the trail making test, the pointing test and losing at rock-paper-scissors—were performed on the baseline and on day 16 of the experiment. There was no significant difference in the results between the baseline and day 16 on all tests, which indicated that executive function was not impaired by the 16-day 6° head-down tilting bed rest. However, we cannot conclude that microgravity did not affect executive function because of the possible contribution of the following factors: (1) the timing of tests, (2) the learning effect, or (3) changes in psychophysiology that were too small to affect higher brain function.

  9. Increased nocturnal fat oxidation in young healthy men with low birth weight

    DEFF Research Database (Denmark)

    Brøns, Charlotte; Lilleøre, S K; Jensen, C B;

    2013-01-01

    , potentially contributing to the development of adiposity and/or T2D compared to matched control subjects. MATERIALS/METHODS: Forty-six young, healthy men were included in the study; 20 with LBW (= 10th percentile) and 26 control subjects with normal birth weight (NBW) (50th-90th percentile). The subjects were......OBJECTIVE: Low birth weight (LBW), a marker of disturbed fetal growth, is associated with adiposity and increased risk of type 2 diabetes (T2D). The aim of the study was to investigate whether LBW is associated with changes in 24-h energy expenditure (EE) and/or substrate utilization rates...... fed a weight maintenance diet and 24-h energy expenditure (EE), respiratory quotient (RQ), and substrate oxidation were assessed in a respiratory chamber. RESULTS: No differences in 24-h EE, RQ or substrate oxidation were observed between LBW and controls. Interestingly, the LBW group exhibited lower...

  10. Intercorrelations of lipoprotein subfractions and their covariation with lifestyle factors in healthy men

    DEFF Research Database (Denmark)

    Parlesak, Alexandr; Eckoldt, J.; Winkler, K.;

    2014-01-01

    So far, little is known about the effect of nutrition and lifestyle on the composition of circulating lipoprotein subfractions. In the current study, we measured the correlations among physical activity, nutrient intake, smoking, body-mass index (BMI), and age with the concentration of triglyceri......So far, little is known about the effect of nutrition and lifestyle on the composition of circulating lipoprotein subfractions. In the current study, we measured the correlations among physical activity, nutrient intake, smoking, body-mass index (BMI), and age with the concentration of...... triglycerides, cholesterol, phospholipids, and apolipoproteins (ApoA1, ApoA2 and ApoB) in subfractions of LDL and HDL in 265 healthy working men. Concentrations of cholesterol, phospholipids, and ApoB in small, dense atherogenic LDL particles (sdLDL) correlated negatively (p<0.001) with those of cholesterol...

  11. Impaired glucose tolerance after brief heat exposure: a randomized crossover study in healthy young men.

    Science.gov (United States)

    Faure, Cécile; Charlot, Keyne; Henri, Stéphane; Hardy-Dessources, Marie-Dominique; Hue, Olivier; Antoine-Jonville, Sophie

    2016-06-01

    A high demand on thermoregulatory processes may challenge homoeostasis, particularly regarding glucose regulation. This has been understudied, although it might concern millions of humans. The objective of this project was to examine the isolated and combined effects of experimental short-term mild heat exposure and metabolic level on glucoregulation. Two experimental randomized crossover studies were conducted. Ten healthy young men participated in study A, which comprises four sessions in a fasting state at two metabolic levels [rest and exercise at 60% of maximal oxygen uptake (O2) for 40 min] in two environmental temperatures (warm: 31°C and control: 22°C). Each session ended with an ad libitum meal, resulting in similar energy intake across sessions. In study B, 12 healthy young men underwent two 3 h oral glucose tolerance tests (OGTTs) in warm and control environmental temperatures. Venous blood was sampled at several time points. In study A, repeated measure ANOVAs revealed higher postprandial serum glucose and insulin levels with heat exposure. Glycaemia following the OGTT was higher in the warm temperature compared with control. The kinetics of the serum glucose response to the glucose load was also affected by the environmental temperature (temperature-by-time interaction, P=0.030), with differences between the warm and control conditions observed up to 90 min after the glucose load (all P<0.033). These studies provide evidence that heat exposure alters short-term glucoregulation. The implication of this environmental factor in the physiopathology of Type 2 diabetes has yet to be investigated. PMID:26980346

  12. Using focus groups to identify factors affecting healthy weight maintenance in college men.

    Science.gov (United States)

    Walsh, Jennifer R; White, Adrienne A; Greaney, Mary L

    2009-06-01

    Healthful eating and physical activity are important for healthy weight maintenance. The hypothesis for this study was that college-aged men would perceive factors affecting eating and physical activity as both contributing to and inhibiting healthy weight maintenance. The overall objective was to explore how men view weight maintenance in the context of these aspects. Subjects (n = 47, mean age = 20.3 +/- 1.7 years) completed an online survey, including the 51-item Three-Factor Eating Questionnaire, and participated in 1 of 6 focus groups. Three face-to-face and 3 online synchronous groups were conducted using a 15-question discussion guide to identify weight maintenance issues around eating, physical activity, and body perceptions. Weight satisfaction decreased with increase in both dietary restraint and disinhibition. Number of attempts to lose weight was positively associated with BMI (r [44] = .465, P = .01) and dietary restraint (r [44] = .515, P = .01). Findings from both focus group formats were similar. Motivators (sports performance/fitness, self-esteem, attractiveness, long-term health) were similar for eating healthfully and being physically active; however, more motivators to be physically active than to eat healthfully emerged. Enablers for eating healthfully included liking the taste, availability of healthful foods, using food rules to guide intake, having a habit of healthful eating, and internal drive/will. Barriers to healthful eating included fat in dairy foods, fruit and vegetable taste, and quick spoilage. Barriers to being physically active included lack of time/time management, obligations, being lazy, and girlfriends. Results may be used to inform future obesity prevention interventions. PMID:19628102

  13. Selenium Status Is Positively Associated with Bone Mineral Density in Healthy Aging European Men

    Science.gov (United States)

    Beukhof, Carolien M.; Medici, Marco; van den Beld, Annewieke W.; Hollenbach, Birgit; Hoeg, Antonia; Visser, W. Edward; de Herder, Wouter W.; Visser, Theo J.; Schomburg, Lutz; Peeters, Robin P.

    2016-01-01

    Objective It is still a matter of debate if subtle changes in selenium (Se) status affect thyroid function tests (TFTs) and bone mineral density (BMD). This is particularly relevant for the elderly, whose nutritional status is more vulnerable. Design and Methods We investigated Se status in a cohort of 387 healthy elderly men (median age 77 yrs; inter quartile range 75–80 yrs) in relation to TFTs and BMD. Se status was determined by measuring both plasma selenoprotein P (SePP) and Se. Results The overall Se status in our population was low normal with only 0.5% (2/387) of subjects meeting the criteria for Se deficiency. SePP and Se levels were not associated with thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroxine (T4), triiodothyronine (T3) or reverse triiodothyronine (rT3) levels. The T3/T4 and T3/rT3 ratios, reflecting peripheral metabolism of thyroid hormone, were not associated with Se status either. SePP and Se were positively associated with total BMD and femoral trochanter BMD. Se, but not SePP, was positively associated with femoral neck and ward's BMD. Multivariate linear analyses showed that these associations remain statistically significant in a model including TSH, FT4, body mass index, physical performance score, age, smoking, diabetes mellitus and number of medication use. Conclusion Our study demonstrates that Se status, within the normal European marginally supplied range, is positively associated with BMD in healthy aging men, independent of thyroid function. Thyroid function tests appear unaffected by Se status in this population. PMID:27055238

  14. GH-releasing peptide-2 does not stimulate arginine vasopressin secretion in healthy men.

    Science.gov (United States)

    Kamoi, Kyuzi; Minagawa, Shinichi; Kimura, Keita; Ishizawa, Masahiro; Ohara, Nobumasa; Uemura, Yasuyuki; Tsuchiya, Junpei

    2010-01-01

    Ghrelin has a stimulating effect on arginine vasopressin (AVP). However, it is not known whether GHRP-2, a synthetic ghrelin receptor agonist, also has a stimulating effect on AVP release in men. To determine whether the GHRP-2 test is useful for assessing AVP secretion, blood ACTH, GH, FSH, LH, PRL, TSH and AVP levels, as well as glucose, osmolality, sodium and hematocrit, were measured before and 15, 30, 45 and 60 min after an intravenous bolus of 100 microg GHRP-2 in 10 healthy men with and without fasting. Blood pressure was measured at 15-min intervals. AVP secretion was not stimulated by the GHRP-2 test with and without fasting. There were no significant differences in hematocrit, blood pressure and plasma osmolality before and after GFRP-2 injection, although significant (p<0.001) peak blood GH, and ACTH and PRL levels were observed 30 and 15 min after GHRP-2 injection with and without fasting, respectively, and the maximal peaks were significantly (p<0.05) higher with fasting than without fasting. These results suggest that AVP secretion is not stimulated by the GHRP-2 test both with and without fasting, though GH, ACTH and PRL levels were higher with than without fasting. PMID:19907099

  15. Assessment of Fat distribution and Bone quality with Trabecular Bone Score (TBS) in Healthy Chinese Men.

    Science.gov (United States)

    Lv, Shan; Zhang, Aisen; Di, Wenjuan; Sheng, Yunlu; Cheng, Peng; Qi, Hanmei; Liu, Juan; Yu, Jing; Ding, Guoxian; Cai, Jinmei; Lai, Bin

    2016-01-01

    Whether fat is beneficial or detrimental to bones is still controversial, which may be due to inequivalence of the fat mass. Our objective is to define the effect of body fat and its distribution on bone quality in healthy Chinese men. A total of 228 men, aged from 38 to 89 years, were recruited. BMD, trabecular bone score (TBS), and body fat distribution were measured by dual-energy X-ray absorptiometry. Subcutaneous and visceral fat were assessed by MRI. In the Pearson correlation analysis, lumbar spine BMD exhibited positive associations with total and all regional fat depots, regardless of the fat distribution. However, the correlation disappeared with adjusted covariables of age, BMI, HDL-C, and HbA1c%. TBS was negatively correlated with fat mass. In multiple linear regression models, android fat (and not gynoid, trunk, or limbs fat) showed significant inverse association with TBS (β = -0.611, P android fat and visceral fat, may have negative effects on bone microstructure; whereas body fat mass contributes to BMD through mechanical loading. PMID:27112305

  16. Dihydrotestosterone Administration Does Not Increase Intraprostatic Androgen Concentrations or Alter Prostate Androgen Action in Healthy Men: A Randomized-Controlled Trial

    OpenAIRE

    Page, Stephanie T; Lin, Daniel W.; Mostaghel, Elahe A.; Marck, Brett T.; Wright, Jonathan L; Wu, Jennifer; Amory, John K.; Peter S Nelson; Matsumoto, Alvin M.

    2010-01-01

    Exogenous dihydrotestosterone (DHT), which substantially raises serum DHT and lowers serum T, does not significantly alter intraprostatic androgen levels or androgen-responsive gene expression in healthy men.

  17. Influence of GLP-1 on Myocardial Glucose Metabolism in Healthy Men during Normo- or Hypoglycemia

    DEFF Research Database (Denmark)

    Gejl, Michael; Lerche, Susanne; Mengel, Annette;

    2014-01-01

    BACKGROUND AND AIMS: Glucagon-like peptide-1 (GLP-1) may provide beneficial cardiovascular effects, possibly due to enhanced myocardial energetic efficiency by increasing myocardial glucose uptake (MGU). We assessed the effects of GLP-1 on MGU in healthy subjects during normo- and hypoglycemia....... MATERIALS AND METHODS: We included eighteen healthy men in two randomized, double-blinded, placebo-controlled cross-over studies. MGU was assessed with GLP-1 or saline infusion during pituitary-pancreatic normo- (plasma glucose (PG): 4.5 mM, n = 10) and hypoglycemic clamps (PG: 3.0 mM, n = 8) by positron...... emission tomography with (18)fluoro-deoxy-glucose ((18)F-FDG) as tracer. RESULTS: In the normoglycemia study mean (± SD) age was 25±3 years, and BMI was 22.6±0.6 kg/m(2) and in the hypoglycemia study the mean age was 23±2 years with a mean body mass index of 23±2 kg/m(2). GLP-1 did not change MGU during...

  18. Cardiorespiratory Responses and Prediction of Peak Oxygen Uptake during the Shuttle Walking Test in Healthy Sedentary Adult Men

    OpenAIRE

    Camila D C Neves; Ana Cristina Rodrigues Lacerda; Lage, Vanessa K. S.; Lima, Liliana P.; Fonseca, Sueli F.; Núbia C. P. Avelar; Teixeira, Mauro M; Mendonça, Vanessa A

    2015-01-01

    BACKGROUND: The application of the Shuttle Walking Test (SWT) to assess cardiorespiratory fitness and the intensity of this test in healthy participants has rarely been studied. This study aimed to assess and correlate the cardiorespiratory responses of the SWT with the cardiopulmonary exercise testing (CEPT) and to develop a regression equation for the prediction of peak oxygen uptake (VO2 peak) in healthy sedentary adult men. METHODS: In the first stage of this study, 12 participants underw...

  19. Exercise-induced splanchnic hypoperfusion results in gut dysfunction in healthy men.

    Directory of Open Access Journals (Sweden)

    Kim van Wijck

    Full Text Available BACKGROUND: Splanchnic hypoperfusion is common in various pathophysiological conditions and often considered to lead to gut dysfunction. While it is known that physiological situations such as physical exercise also result in splanchnic hypoperfusion, the consequences of flow redistribution at the expense of abdominal organs remained to be determined. This study focuses on the effects of splanchnic hypoperfusion on the gut, and the relationship between hypoperfusion, intestinal injury and permeability during physical exercise in healthy men. METHODS AND FINDINGS: Healthy men cycled for 60 minutes at 70% of maximum workload capacity. Splanchnic hypoperfusion was assessed using gastric tonometry. Blood, sampled every 10 minutes, was analyzed for enterocyte damage parameters (intestinal fatty acid binding protein (I-FABP and ileal bile acid binding protein (I-BABP. Changes in intestinal permeability were assessed using sugar probes. Furthermore, liver and renal parameters were assessed. Splanchnic perfusion rapidly decreased during exercise, reflected by increased gap(g-apCO(2 from -0.85±0.15 to 0.85±0.42 kPa (p<0.001. Hypoperfusion increased plasma I-FABP (615±118 vs. 309±46 pg/ml, p<0.001 and I-BABP (14.30±2.20 vs. 5.06±1.27 ng/ml, p<0.001, and hypoperfusion correlated significantly with this small intestinal damage (r(S = 0.59; p<0.001. Last of all, plasma analysis revealed an increase in small intestinal permeability after exercise (p<0.001, which correlated with intestinal injury (r(S = 0.50; p<0.001. Liver parameters, but not renal parameters were elevated. CONCLUSIONS: Exercise-induced splanchnic hypoperfusion results in quantifiable small intestinal injury. Importantly, the extent of intestinal injury correlates with transiently increased small intestinal permeability, indicating gut barrier dysfunction in healthy individuals. These physiological observations increase our knowledge of splanchnic hypoperfusion sequelae, and may

  20. Diurnal variation of vascular diameter and reactivity in healthy young men

    Directory of Open Access Journals (Sweden)

    P.F.D. Bau

    2008-06-01

    Full Text Available The higher incidence of cardiovascular events in the morning is accompanied by an increased vascular tone. However, there are few published studies designed to evaluate the diurnal variation of vascular and endothelial parameters in healthy subjects. In the present investigation, we evaluated the diurnal variation in brachial artery diameter (BAD, flow-mediated dilation (FMD and endothelium-independent dilation (NFMD in a homogeneous sample of healthy non-smoker young men. Fifty subjects aged 20.8 ± 0.3 years (range: 18 to 25 years were investigated by brachial artery ultrasound. Exclusion criteria were female gender and evidence of clinically significant health problems, including obesity. Volunteers were asked to rest and avoid fat meals as well as alcoholic beverages 48 h before and until completion of the evaluations. BAD, FMD and NFMD were measured at 7 am, 5 pm, and 10 pm and tested by repeated measures ANOVA. BAD was smaller at 7 am (mean ± SEM, 3.8 ± 0.1 mm in comparison with 5 pm (3.9 ± 0.1 and 10 pm (4.0 ± 0.1 mm; P < 0.001. FMD values did not change significantly during the day, while NFMD increased more at 7 am (18.5 ± 1.1%, when compared to 15.5 ± 0.9% at 10 pm and 15.5 ± 0.9% at 5 pm (P = 0.04. The physiological state of vasoconstriction after awakening, with preserved capability to dilate in the morning, should be considered to be part of the healthy cardiovascular adaptation before considering later life risk factors and endothelial dysfunction.

  1. Chronic stress exposure decreases the cortisol awakening response in healthy young men.

    Science.gov (United States)

    Duan, Hongxia; Yuan, Yiran; Zhang, Liang; Qin, Shaozheng; Zhang, Kan; Buchanan, Tony W; Wu, Jianhui

    2013-11-01

    Academic examination is a major stressor for students in China. Investigation of stress-sensitive endocrine responses to major examination stress serves as a good model of naturalistic chronic psychological stress in an otherwise healthy population. The cortisol awakening response (CAR) is an endocrine marker of the hypothalamic-pituitary-adrenocortical (HPA) axis in response to stress. However, it remains unknown how chronic examination stress impacts the CAR in a young healthy population To exclude the influence of sex effects on hormone level, the CAR and psychological stress responses were assessed on two consecutive workdays in 42 male participants during their preparations for the Chinese National Postgraduate Entrance Exam (NPEE) and 21 non-exam, age-matched male comparisons. On each day, four saliva samples were collected immediately after awakening, 15 minutes, 30 minutes and 60 minutes after awakening. The waking level (S1), the increase within 30 minutes after awakening (R30), the area under the curve with respect to ground (AUCg), and the area under the curve with respect to increase (AUCi) were used to quantify the CAR. Psychological stress and anxiety were assessed by the Perceived Stress Scale and the Spielberger State-Trait Anxiety Inventory, respectively. Male participants in the exam group had greater perceived stress and anxiety scores relatibe to the non-exam group. Both R30 and AUCi in the exam group were significantly lower than the comparison group and this effect was most pronounced for participants with high levels of perceived stress in the exam group. Perceived stress and anxiety levels were negatively correlated with both R30 and AUCi. Chronic examination stress can lead to the decrease of CAR in healthy young men, possibly due to reduced HPA axis activity under long-term sustained stress. PMID:23992539

  2. Aromatase imaging with [N-methyl-C-11]vorozole PET in healthy men and women

    International Nuclear Information System (INIS)

    Aromatase, the last and obligatory enzyme catalyzing estrogen biosynthesis from androgenic precursors, can be labeled in vivo with (11)C-vorozole. Aromatase inhibitors are widely used in breast cancer and other endocrine conditions. The present study aims to provide baseline information defining aromatase distribution in healthy men and women, against which its perturbation in pathological situations can be studied. Methods: (11)C-vorozole (111-296 MBq/subject) was injected I.V in 13 men and 20 women (age range 23 to 67). PET data were acquired over a 90 minute period. Each subject had 4 scans, 2/day separated by 2-6 weeks, including brain and torso or pelvis scans. Young women were scanned at 2 discrete phases of the menstrual cycle (midcycle and late luteal). Men and postmenopausal women were also scanned following pretreatment with a clinical dose of the aromatase inhibitor letrozole.Time activity curves were obtained and standard uptake values (SUV) calculated for major organs including brain, heart, lungs, liver, kidneys, spleen, muscle, bone and male and female reproductive organs (penis, testes, uterus, ovaries). Organ and whole body radiation exposures were calculated using Olinda software. Results: Liver uptake was higher than all other organs, but was not blocked by pretreatment with letrozole. Mean SUVs in men were higher than in women, and brain uptake was blocked by letrozole. Male brain SUVs were also higher than all other organs (ranging from 0.48±0.05 in lungs to 1.5±0.13 in kidneys). Mean ovarian SUVs (3.08±0.7) were comparable to brain levels and higher than all other organs. Furthermore, ovarian SUVs In young women around the time of ovulation (midcycle) were significantly higher than those measured in the late luteal phase, while aging and cigarette smoking reduced (11)C-vorozole uptake. Conclusions: PET with (11)C-vorozole is useful for assessing physiological changes in estrogen synthesis capacity in the human body. Baseline levels in

  3. Total body water estimations in healthy men and women using bioimpedance spectroscopy: a deuterium oxide comparison

    Directory of Open Access Journals (Sweden)

    Bemben Michael G

    2008-03-01

    Full Text Available Abstract Background Total body water (TBW estimations have been used to estimate body composition, particularly fat-free mass, to aid in nutritional interventions, and to monitor hydration status. In the past, bioimpedance spectroscopy (BIS devices have been used to estimate TBW. Previous investigations have examined the validity of the XiTRON 4000B (XiTRON Technologies BIS device for estimating TBW. Recently, a new BIS device (Imp™ SFB7 has become available, claiming greater precision when estimating TBW. The Imp™ SFB7 (SFB7 is based on similar BIS principles, while offering increased portability and a greater range of frequencies when compared to older devices, such as the XiTRON 4000B (4000B. The purpose of this study was to examine the validity of the SFB7 for estimating total body water in healthy college-age men and women compared to the 4000B and deuterium oxide (D2O. Methods Twenty-eight Caucasian men and women (14 men, 14 women; 24 ± 4 yrs; 174.6 ± 8.7 cm; 72.80 ± 17.58 kg had their TBW estimated by the SFB7, the 4000B, and D2O. Results Both BIS devices produced similar standard error of estimate (SEE and r values (SFB7, SEE = 2.12L, r = 0.98; 4000B, SEE = 2.99L, r = 0.96 when compared to D2O, though a significant constant error (CE was detected for the 4000B (2.26L, p ≤ 0.025. The 4000B produced a larger total error (TE and CE (TE = 3.81L, CE = 2.26L when compared to the SFB7 (TE = 2.21L, CE = -0.09L. Additionally, the limits of agreement were larger for the 4000B (-3.88 to 8.39L than the SFB7 (-4.50 to 4.31L. These results were consistent when sex was analyzed separately, though women produced lower SEE and TE values for both devices. Conclusion The 4000B and SFB7 are valid BIS devices when compared to D2O to estimate TBW in college-age Caucasian men and women. Furthermore, the new SFB7 device displayed greater precision in comparison to the 4000B, which may decrease the error when estimating TBW on an individual basis.

  4. Survival Following Radiation and Androgen Suppression Therapy for Prostate Cancer in Healthy Older Men: Implications for Screening Recommendations

    International Nuclear Information System (INIS)

    Purpose: The U.S. Preventive Services Task Force has recommended against screening men over 75 for prostate cancer. We examined whether older healthy men could benefit from aggressive prostate cancer treatment. Methods and Materials: 206 men with intermediate to high risk localized prostate cancer randomized to 70 Gy of radiation (RT) or RT plus 6 months of androgen suppression therapy (RT+AST) constituted the study cohort. Within subgroups stratified by Adult Comorbidity Evaluation-27 comorbidity score and age, Cox multivariable analysis was used to determine whether treatment with RT+AST as compared with RT was associated with a decreased risk of death. Results: Among healthy men (i.e., with mild or no comorbidity), 78 were older than the median age of 72.4 years, and in this subgroup, RT+AST was associated with a significantly lower risk of death on multivariable analysis (adjusted hazard ratio = 0.36 (95% CI=0.13-0.98), p = 0.046, with significantly lower 8-year mortality estimates of 16.5% vs. 41.4% (p = 0.011). Conversely, among men with moderate or severe comorbidity, 24 were older than the median age of 73, and in this subgroup, treatment with RT+AST was associated with a higher risk of death (adjusted hazard ratio = 5.2 (1.3-20.2), p = 0.018). Conclusion: In older men with mild or no comorbidity, treatment with RT+AST was associated with improved survival compared with treatment with RT alone, suggesting that healthy older men may derive the same benefits from prostate cancer treatment as younger men. We therefore suggest that prostate cancer screening recommendations should not be based on strict age cutoffs alone but should also take into account comorbidity.

  5. Twenty-four hours of insulin infusion does not lower plasma lipoprotein(a) in healthy men

    NARCIS (Netherlands)

    Riemens, SC; Dullaart, RPF

    2000-01-01

    The effect of 24-h exogenous hyperinsulinaemia on the plasma level of the atherogenic lipoprotein(a) (Lp(a)) is unknown. We evaluated the responses of plasma cholesterol, triglycerides, apolipoprotein (apo) B and Lp(a) during 24-h insulin infusion (180 pmol/kg/h) in 6 healthy men. Plasma total chole

  6. Effects of a Growth Hormone-Releasing Hormone Analog on Endogenous GH Pulsatility and Insulin Sensitivity in Healthy Men

    OpenAIRE

    Stanley, Takara L.; Chen, Cindy Y.; Branch, Karen L.; Makimura, Hideo; GRINSPOON, Steven K.

    2010-01-01

    Context and Objective: Strategies to augment pulsatile GH may be beneficial in patients with excess visceral adiposity, in whom GH secretion is reduced. The objective of this study was to determine the effects of a novel GHRH (GHRH1–44) analog, tesamorelin, on endogenous GH pulsatility and insulin sensitivity in healthy men.

  7. Chronic TNF-a neutralization does not improve insulin resistance or endothelial function in "healthy" men with metabolic syndrome

    NARCIS (Netherlands)

    Wascher, T.C.; Lindeman, J.H.N.; Sourij, H.; Kooistra, T.; Pacini, G.; Roden, M.

    2011-01-01

    The possible contribution of tumor necrosis factor-a (TNF-a) to the development of obesity associated insulin resistance in humans is still controversial. Our study investigated the effect of TNF-a neutralization on insulin resistance in healthy, obese and insulin resistant men. We performed a prosp

  8. Effect of hyperbaric oxygen and vitamin C and E supplementation on biomarkers of oxidative stress in healthy men

    DEFF Research Database (Denmark)

    Bader, Nicolle; Bosy-Westphal, Anja; Koch, Andreas; Rimbach, Gerald; Weimann, Allan; Poulsen, Henrik E; Müller, Manfred J

    2007-01-01

    healthy men were exposed to HBO (100 % O2; 240 kPa) before and after 4 weeks' supplementation with 500 mg vitamin C plus 165 mg alpha-tocopherol equivalents. Exposure to 21 % O2 at 100 kPa served as intra-individual controls (control). Samples for the analysis of plasma antioxidants and oxidative stress...

  9. The effects of eating marine- or vegetable-fed farmed trout on the human plasma proteome profiles of healthy men

    DEFF Research Database (Denmark)

    Rentsch, Maria Louise; Lametsch, René; Bügel, Susanne;

    2015-01-01

    present study was to evaluate the impact of regular fish intake on the plasma proteome. We recruited thirty healthy men aged 40 to 70 years, who were randomly allocated to a daily meal of chicken or trout raised on vegetable or marine feeds. Blood samples were collected before and after 8 weeks of...

  10. Effects of short-term nutritional interventions on right ventricular function in healthy men.

    Directory of Open Access Journals (Sweden)

    Ralph L Widya

    Full Text Available BACKGROUND: A physiological model of increased plasma nonesterified fatty acid (NEFA levels result in myocardial triglyceride (TG accumulation, which is related to cardiac dysfunction. A pathophysiological model of increased plasma NEFA levels result in hepatic steatosis, which has been linked to abnormal myocardial energy metabolism. Hepatic steatosis is accompanied by hepatic inflammation, reflected by plasma cholesteryl ester transfer protein (CETP levels. The current study aimed to investigate effects of these models via different nutritional interventions on right ventricular (RV function. METHODS: Fifteen men (age 25.0±6.6 years were included and underwent magnetic resonance imaging and spectroscopy in this prospective crossover intervention study. RV function, myocardial and hepatic TG content, and CETP levels were assessed on three occasions: after normal diet, very low-calorie diet (VLCD, physiological model and high-fat high-energy (HFHE, pathophysiological model diet (all 3-days diets, randomly ordered, washout phase at least 14 days. RESULTS: VLCD induced a decrease in mean E deceleration by 27%. Myocardial TG content increased by 55%, whereas hepatic TG content decreased by 32%. Plasma CETP levels decreased by 14% (all P<0.05. HFHE diet induced a decrease in E/A by 19% (P<0.05. Myocardial TG content did not change, whereas hepatic TG content increased by 112% (P<0.01. Plasma CETP levels increased by 14% (P<0.05. CONCLUSIONS: These findings show that RV diastolic function is impaired after short-term VLCD and HFHE diet in healthy men, respectively a physiological and a pathophysiological model of increased plasma NEFA levels. After short-term VLCD, myocardial lipotoxicity may be of importance in decreased RV diastolic function. RV diastolic dysfunction is accompanied by increased hepatic TG content and plasma CETP levels after short-term HFHE diet, suggesting that systemic inflammation reflecting local macrophage infiltration in the

  11. Cardiovascular function is better in veteran football players than age-matched untrained elderly healthy men

    DEFF Research Database (Denmark)

    Schmidt, Jakob Friis; Andersen, Thomas Rostgaard; Andersen, Lars Juel;

    2015-01-01

    addition, RHI was 21% higher (P < 0.05) in VPG. VPG also had lower body mass index (P < 0.05), body fat percentage, total body fat mass, android fat percentage, and gynoid fat percentage (all P < 0.01). Lifelong participation in football training is associated with better LV systolic function, physical......The aim of the study was to determine whether lifelong football training may improve cardiovascular function, physical fitness, and body composition. Our subjects were 17 male veteran football players (VPG; 68.1 ± 2.1 years) and 26 healthy age-matched untrained men who served as a control group (CG......; 68.2 ± 3.2 years). Examinations included measurements of cardiac function, microvascular endothelial function [reactive hyperemic index (RHI)], maximum oxygen uptake (VO2max), and body composition. In VPG, left ventricular (LV) end-diastolic volume was 20% larger (P < 0.01) and LV ejection fraction...

  12. Single oral dose pharmacokinetics of decursin and decursinol angelate in healthy adult men and women.

    Directory of Open Access Journals (Sweden)

    Jinhui Zhang

    Full Text Available The ethanol extract of Angelica gigas Nakai (AGN root has promising anti-cancer and other bioactivities in rodent models. It is currently believed that the pyranocoumarin isomers decursin (D and decursinol angelate (DA contribute to these activities. We and others have documented that D and DA were rapidly converted to decursinol (DOH in rodents. However, our in vitro metabolism studies suggested that D and DA might be metabolized differently in humans. To test this hypothesis and address a key question for human translatability of animal model studies of D and DA or AGN extract, we conducted a single oral dose human pharmacokinetic study of D and DA delivered through an AGN-based dietary supplement Cogni.Q (purchased from Quality of Life Labs, Purchase, NY in twenty healthy subjects, i.e., 10 men and 10 women, each consuming 119 mg D and 77 mg DA from 4 vegicaps. Analyses of plasma samples using UHPLC-MS/MS showed mean time to peak concentration (Tmax of 2.1, 2.4 and 3.3 h and mean peak concentration (Cmax of 5.3, 48.1 and 2,480 nmol/L for D, DA and DOH, respectively. The terminal elimination half-life (t1/2 for D and DA was similar (17.4 and 19.3 h and each was much longer than that of DOH (7.4 h. The mean area under the curve (AUC0-48h for D, DA and DOH was estimated as 37, 335 and 27,579 h∙nmol/L, respectively. Gender-wise, men absorbed the parent compounds faster and took shorter time to reach DOH peak concentration. The human data supported an extensive conversion of D and DA to DOH, even though they metabolized DA slightly slower than rodents. Therefore, the data generated in rodent models concerning anti-cancer efficacy, safety, tissue distribution and pharmacodynamic biomarkers will likely be relevant for human translation.ClinicalTrials.gov NCT02114957.

  13. What are the main barriers to healthy eating among families? A qualitative exploration of perceptions and experiences of Tehranian men.

    Science.gov (United States)

    Farahmand, Maryam; Amiri, Parisa; Ramezani Tehrani, Fahimeh; Momenan, Amir Abbas; Mirmiran, Parvin; Azizi, Fereidoun

    2015-06-01

    Despite women playing a pivotal role in shaping nutritional patterns in their families, it is the men whose ideas and preferences, after children, influence the selection and consumption of daily foods among Iranian families. This study focused on exploring the main barriers to healthy eating as experienced by male participants of the Tehran Lipid Glucose Study (TLGS). A grounded theory approach was used for analyzing participants' experiences and their perceptions regarding these barriers. Participants were 98 men, aged 25-65 years, selected and recruited from the TGLS cohort. Data collection was conducted through fourteen semi-structured focus group discussions, between 2008 and 2009. All interviews and focus group discussions were audio recorded and transcribed verbatim. Constant comparative analysis of the data was conducted manually according to the Strauss and Corbin analysis method. The most important barriers to healthy eating were: (i) Personal factors, which included two subthemes--lack of knowledge and personal taste, (ii) Communication and modeling included two subthemes--other individuals and media/advertisements; (iii) Modernization included two subthemes--nutrition transition and women's role; and (iv) Lack of access to healthy foods, which included four subthemes--Inadequate confidence, perceived risk, high cost and time limitations. Appropriate attention and prioritized policy-making to modify the socio-environmental barriers to healthy eating were explored in the current study, along with effective educational programs that could help to promote healthy eating among Iranian families. PMID:25725485

  14. Left Ventricular Function during Acute High-Altitude Exposure in a Large Group of Healthy Young Chinese Men

    OpenAIRE

    Rao, Mingyue; Li, Jiabei; Qin, Jun; Zhang, Jihang; Gao, Xubin; Yu, Shiyong; Yu, Jie; Chen, Guozhu; Xu, Baida; Li, Huijie; Rao, Rongsheng; Huang, Lan; JIN, JUN

    2015-01-01

    Objective The purpose of this study was to observe left ventricular function during acute high-altitude exposure in a large group of healthy young males. Methods A prospective trial was conducted in Szechwan and Tibet from June to August, 2012. By Doppler echocardiography, left ventricular function was examined in 139 healthy young Chinese men at sea level; within 24 hours after arrival in Lhasa, Tibet, at 3700 m; and on day 7 following an ascent to Yangbajing at 4400 m after 7 days of acclim...

  15. Plasma Growth Hormone and Prolactin Levels in Healthy Sedentary Young Men after Short-Term Endurance Training under Hot Environment

    OpenAIRE

    İbrahim Cicioglu; Fatih Kiyici

    2013-01-01

    Pituitary hormones play an important role energy expenditure and body temperature regulation during exercise. The aim of the stu¬dy was to investigate the effect of two different endurance training in ambient temperature (30.76 ± 1.71oC and 57.92 ± 5.80% r.h.) on plasma growth hormone (GH) and prolactin (PRL) levels in non-trained healthy subjects. Twenty-four untrained healthy men participated in an 8-wk progressive two different endurance-training program. Subjects were divided into two gro...

  16. The acute effect of commercially available pulse powders on postprandial glycaemic response in healthy young men.

    Science.gov (United States)

    Anderson, G Harvey; Liu, Yudan; Smith, Christopher E; Liu, Ting Ting; Nunez, Maria Fernanda; Mollard, Rebecca C; Luhovyy, Bohdan L

    2014-12-28

    Whole pulses (beans, peas, chickpeas and lentils) elicit low postprandial blood glucose (BG) responses in adults; however, their consumption in North America is low. One potential strategy to increase the dietary intake of pulses is the utilisation of commercial pulse powders in food products; however, it is unclear whether they retain the biological benefits observed with whole pulses. Therefore, the present study examined the effects of commercially prepared pulse powders on BG response before and after a subsequent meal in healthy young men. Overall, three randomised, within-subject experiments were conducted. In each experiment, participants received whole, puréed and powdered pulses (navy beans in Expt 1; lentils in Expt 2; chickpeas in Expt 3) and whole-wheat flour as the control. All treatments were controlled for available carbohydrate content. A fixed-energy pizza meal (50·2 kJ/kg body weight) was provided at 120 min. BG concentration was measured before (0-120 min) and after (140-200 min) the pizza meal. BG concentration peaked at 30 min in all experiments, and pulse forms did not predict their effect on BG response. Compared with the whole-wheat flour control, navy bean treatments lowered peak BG concentrations (Expt 1, Plentil (Expt 2, P= 0.008) and chickpea (Expt 3, P= 0.002) treatments over 120 min. Processing pulses to powdered form does not eliminate the benefits of whole pulses on BG response, lending support to the use of pulse powders as value-added food ingredients to moderate postprandial glycaemic response. PMID:25327223

  17. Complexity of heartbeat interval series in young healthy trained and untrained men

    International Nuclear Information System (INIS)

    The origin of heart rate variability (HRV) is largely in parasympathetic activity. The direct influence of sympathetic activity and other control mechanisms, especially at an increased HR, is not well understood. The objectives of the study were to investigate the influence of increasing HR on the properties of heartbeat interval (RR) series in young healthy subjects. ECG was recorded in 9 trained and 11 untrained young men during supine rest, standing, incremental running exercise and relaxation. During exercise, a breath-to-breath gas exchange was monitored. The RR time series analysis included the spectral analysis, detrended fluctuations analysis method and sample entropy (SampEn) calculation. During exercise, spectral powers were reduced dramatically in both groups. The dependence of short-term scaling exponent (α1) on the RR included a characteristic maximum, while SampEn for the same value of the RR had a minimum. The value of HR corresponding to the maximum of α1 and minimum of SampEn (IHR) corresponded to the intrinsic HR obtained by an autonomic blockade. In trained subjects, the curves α1 versus RR and SampEn versus RR were moved toward larger RR, compared with control. For HR values higher than IHR, α1 decreased and SampEn increased. These results reveal that the complexity of the heart rhythm above intrinsic HR decreases with an increase in HR. We suggest that at the highest HR intrinsic heart control is reflected in the heart rhythm. We point out the possibility of developing a new non-invasive method for the determination of intrinsic HR from the curve α1 versus RR

  18. Effects of age and physical activity on the autonomic control of heart rate in healthy men

    Directory of Open Access Journals (Sweden)

    R.C. Melo

    2005-09-01

    Full Text Available The effects of the aging process and an active life-style on the autonomic control of heart rate (HR were investigated in nine young sedentary (YS, 23 ± 2.4 years, 16 young active (YA, 22 ± 2.1 years, 8 older sedentary (OS, 63 ± 2.4 years and 8 older active (OA, 61 ± 1.1 years healthy men. Electrocardiogram was continuously recorded for 15 min at rest and for 4 min in the deep breathing test, with a breath rate of 5 to 6 cycles/min in the supine position. Resting HR and RR intervals were analyzed by time (RMSSD index and frequency domain methods. The power spectral components are reported in normalized units (nu at low (LF and high (HF frequency, and as the LF/HF ratio. The deep breathing test was analyzed by the respiratory sinus arrhythmia indices: expiration/inspiration ratio (E/I and inspiration-expiration difference (deltaIE. The active groups had lower HR and higher RMSSD index than the sedentary groups (life-style condition: sedentary vs active, P < 0.05. The older groups showed lower HFnu, higher LFnu and higher LF/HF ratio than the young groups (aging effect: young vs older, P < 0.05. The OS group had a lower E/I ratio (1.16 and deltaIE (9.7 bpm than the other groups studied (YS: 1.38, 22.4 bpm; YA: 1.40, 21.3 bpm; OA: 1.38, 18.5 bpm. The interaction between aging and life-style effects had a P < 0.05. These results suggest that aging reduces HR variability. However, regular physical activity positively affects vagal activity on the heart and consequently attenuates the effects of aging in the autonomic control of HR.

  19. Effects of upright and recumbent cycling on executive function and prefrontal cortex oxygenation in young, healthy, men

    OpenAIRE

    Faulkner, J.; Lambrick, D.; Kaufmann, S.; Stoner, L

    2016-01-01

    Background: The purpose of this study was to assess the acute effects of posture (upright vs. recumbent) during moderate-intensity cycle exercise on executive function and prefrontal cortex oxygenation, in young healthy adults. Methods: Seventeen physically active men (24.6 ± 4.3y) completed two 30-minute submaximal, exercise tests (Conditions: upright and recumbent cycle ergometry). Executive function was assessed using the ‘colour’ and ‘word’ Stroop task, pre- (resting) and post-exerci...

  20. Bolus ingestion of individual branched-chain amino acids alters plasma amino acid profiles in young healthy men

    OpenAIRE

    Matsumoto, Takuya; Nakamura, Koichi; Matsumoto, Hideki; Sakai, Ryosei; Kuwahara, Tomomi; Kadota, Yoshihiro; Kitaura, Yasuyuki; SATO, JUICHI; Shimomura, Yoshiharu

    2014-01-01

    Physiological conditions in humans affect plasma amino acid profiles that might have potential for medical use. Because the branched-chain amino acids (BCAAs) leucine, isoleucine and valine are used as medicines and supplements, we investigated the acute effects of individual BCAAs (10–90 mg/kg body weight) or mixed BCAAs ingested as a bolus on plasma amino acid profiles in young healthy men. Plasma leucine levels rapidly increased and peaked around 30 min after leucine ingestion. Concentrati...

  1. The effect of farmed trout on cardiovascular risk markers in healthy men

    DEFF Research Database (Denmark)

    Hallund, Jesper; Madsen, Birgitte Overgaard; Bügel, Susanne H.;

    2010-01-01

    -cholesterol, glucose, insulin, C-reactive protein (CRP) and other markers of inflammation were measured at weeks 0 and 8. RBC content of total n-3 LCPUFA, both EPA and DHA, was significantly higher among men consuming trout raised on marine feed compared with men consuming the vegetable-fed trout or chicken. The three...

  2. Motivators and barriers to engaging in healthy eating and physical activity in young adult men

    Science.gov (United States)

    Internationally, young men (aged 18-25 years) have a high prevalence of overweight and obesity and many fail to meet recommended levels of physical activity or dietary guidelines. There is a lack of engagement and understanding of young men's needs in health-related research. Therefore, this study a...

  3. Hippocampal - brainstem connectivity associated with vagal modulation after an intense exercise intervention in healthy men

    Directory of Open Access Journals (Sweden)

    Karl Juergen Bär

    2016-04-01

    Full Text Available AbstractRegular physical exercise leads increased vagal modulation of the cardiovascular system. A combination of peripheral and central processes has been proposed to underlie this adaptation. However, specific changes in the central autonomic network have not been described in human in more detail. We hypothesized that the anterior hippocampus known to be influenced by regular physical activity might be involved in the development of increased vagal modulation after a 6 weeks high intensity intervention in young healthy men (exercise group: n=17, control group: n=17. In addition to the determination of physical capacity before and after the intervention, we used resting state functional magnetic resonance imaging and synchronic heart rate variability assessment.We detected a significant increase of the power output at the anaerobic threshold of 11.4% (p<0.001, the maximum power output Pmax of 11.2% (p<0.001, and VO2max adjusted for body weight of 4.7% (p<0.001 in the exercise group (EG. Comparing baseline (T0 and post-exercise (T1 values of parasympathetic modulation of the exercise group, we observed a trend for a decrease in heart rate (p<0.06 and a significant increase of vagal modulation as indicated by RMSSD (p<0.026 during resting state. In the whole brain analysis, we found that the connectivity pattern of the right anterior hippocampus (aHC was specifically altered to the ventromedial anterior cortex, the dorsal striatum and to the dorsal vagal complex (DVC in the brainstem. Moreover, we only observed a highly significant negative correlation between increased RMSSD after exercise and decreased functional connectivity from the right aHC to DVC (r=-0.69, p=0.003. This indicates that increased vagal modulation was associated with functional connectivity between aHC and the dorsal vagal complex.In conclusion, our findings suggest that exercise associated changes in anterior hippocampal function might be involved in increased vagal

  4. Association of Arterial Stiffness and Osteoporosis in Healthy Men Undergoing Screening Medical Examination

    OpenAIRE

    Kim, Nam Lee; Jang, Ha Min; Kim, Sul Ki; Ko, Ki Dong; Hwang, In Cheol; Suh, Heuy Sun

    2014-01-01

    Background Association of arterial stiffness and osteoporosis has been previously reported in women. However, this association is still controversial for men. Therefore, we investigated correlation of arterial stiffness and osteoporosis by measuring brachial-ankle (ba) pulse wave velocity (PWV) and bone mineral density (BMD). Methods We reviewed medical charts of 239 people (women: 128, men: 111) who visited the Health Promotion Center, retrospectively. ba-PWV was measured by automatic wave a...

  5. Prevalence of dieting among working men and women: the healthy worker project.

    Science.gov (United States)

    Jeffery, R W; Adlis, S A; Forster, J L

    1991-01-01

    Examined dieting to lose weight in a population of 2,107 men and 2,540 women employed in 32 worksites in the upper Midwest. Lifetime prevalence of this behavior was estimated to be 47% in men and 75% in women, and point prevalence was reported as 13% and 25% in men and women, respectively. Lifetime prevalence of participation in organized weight-loss programs was 6% in men and 31% in women; current prevalence was 1% in men and 6% in women. The strongest correlate of dieting behavior was relative body weight. In logistic regression analyses, dieting tended to be associated positively with education and occupational status and, in men only, was more prevalent among those with a history of hypertension. Dieters reported lower food intakes than nondieters, but the two groups did not differ consistently in reported physical activity. Overall, dieting appears to be a pervasive behavioral U.S. phenomenon that may contribute in part to population differences in the prevalence of obesity. PMID:1915214

  6. Self-reported onset of puberty and subsequent semen quality and reproductive hormones among 1,068 healthy young Danish men

    DEFF Research Database (Denmark)

    Jensen, Tina Kold; Finne, Katrine Folmann; Skakkebæk, Niels Erik;

    2016-01-01

    STUDY QUESTION: Is there an association between pubertal onset and subsequent reproductive health in young men? SUMMARY ANSWER: Self-reported later onset of puberty was associated with reduced semen quality and altered serum levels of reproductive hormones among 1068 healthy, young Danish men. WH...

  7. Cardiorespiratory responses and prediction of peak oxygen uptake during the shuttle walking test in healthy sedentary adult men.

    Directory of Open Access Journals (Sweden)

    Camila D C Neves

    Full Text Available BACKGROUND: The application of the Shuttle Walking Test (SWT to assess cardiorespiratory fitness and the intensity of this test in healthy participants has rarely been studied. This study aimed to assess and correlate the cardiorespiratory responses of the SWT with the cardiopulmonary exercise testing (CEPT and to develop a regression equation for the prediction of peak oxygen uptake (VO2 peak in healthy sedentary adult men. METHODS: In the first stage of this study, 12 participants underwent the SWT and the CEPT on a treadmill. In the second stage, 53 participants underwent the SWT twice. In both phases, the VO2 peak, respiratory exchange ratio (R, and heart rate (HR were evaluated. RESULTS: Similar results in VO2 peak (P>0.05, R peak (P>0.05 and predicted maximum HR (P>0.05 were obtained between the SWT and CEPT. Both tests showed strong and significant correlations of VO2 peak (r = 0.704, P = 0.01 and R peak (r = 0.737, P0.05 was found. CONCLUSIONS: The SWT produced maximal cardiorespiratory responses comparable to the CEPT, and the developed equation showed viability for the prediction of VO2 peak in healthy sedentary men.

  8. A Comparative Study of the Effect of Local and General Fatigue on Sense of Force in Healthy Young Men

    OpenAIRE

    Minoo Khalkhali; Mostafa Bazrafkan; Khosro Khademi Kalantari; Asghar Rezasoltani

    2012-01-01

    Background and Aim: Fatigue has been proposed as one of underlying causes of musculo-skeletal injuries. Proprioceptive impairment seems to be one of the causes for this phenomenon. Few studies have investigated the effect of local fatigue on sense of force, but the effect of general fatigue on sense of force have not been studied yet. The objective of this study is to investigate the effects of local and general fatigue on sense of force and their comparison in healthy young men.Material & Me...

  9. Comparison of two long-acting preparations of metoprolol with conventional metoprolol and atenolol in healthy men during chronic dosing.

    OpenAIRE

    Freestone, S; Silas, J H; Lennard, M. S.; Ramsay, L E

    1982-01-01

    1 Eight healthy men received two long-acting formulations of metoprolol 200 mg (SA Astra, SR Geigy), conventional metoprolol 200 mg and atenolol 100 mg once daily for 1 week each in balanced, crossover fashion. There was a washout period of at least a week between each phase. 2 On the last day of each phase, post-exercise heart rate was recorded at intervals and compared to pretreatment values. Plasma metoprolol concentrations were measured. 3 The mean AUC was similar after each of the three ...

  10. Association between serum total testosterone and Body Mass Index in middle aged healthy men

    OpenAIRE

    Shamim, Muhammad Omar; Ali Khan, Farooq Munfaet; Arshad, Rabia

    2015-01-01

    Objective: To determine correlation of serum total testosterone with body mass index (BMI) and waist hip ratio (WHR) in healthy adult males. Methods: A cross sectional study was conducted on 200 nonsmoker healthy males (aged 30-50 years) university employees. They were selected by convenience sampling technique after a detailed medical history and clinical examination including BMI and Waist Hip Ratio (WHR) calculation. Blood sampling was carried out to measure serum total testosterone (TT) u...

  11. Kinesio Taping Does Not Alter Quadriceps Isokinetic Strength and Power in Healthy Nonathletic Men: A Prospective Crossover Study

    Directory of Open Access Journals (Sweden)

    Paweł Korman

    2015-01-01

    Full Text Available Objectives. The effects of Kinesio Taping (KT on muscular performance remain largely unclear. This study aimed to investigate the acute effects of KT on the maximum concentric and eccentric quadriceps isokinetic strength. Study Design. This is a single-blinded, placebo crossover, repeated measures study. Methods. Maximum isokinetic concentric/eccentric extension torque, work, and power were assessed by an isokinetic dynamometer without taping (NT and with KT or placebo taping (PT in 17 healthy young men. Repeated measures one-way analysis of variance (ANOVA was used for statistical analyses. Results. Testing concentric contractions at 60°/s or 180°/s isokinetic speed, no significant differences in peak torque (Nm, total work (J, or mean power (W were noted among the application modes under different conditions. Testing eccentric contractions at 30°/s or 60°/s isokinetic speed, no significant differences in mentioned parameters were noted, respectively. KT on the quadriceps neither decreased nor increased muscle strength in the participants. Conclusion. KT application onto the skin overlying the quadriceps muscle does not enhance the strength or power of knee extensors in healthy men.

  12. Endothelial glycocalyx integrity is preserved in young, healthy men during a single bout of strenuous physical exercise.

    Science.gov (United States)

    Majerczak, J; Duda, K; Chlopicki, S; Bartosz, G; Zakrzewska, A; Balcerczyk, A; Smoleński, R T; Zoladz, J A

    2016-06-20

    In the present study we aimed to evaluate whether oxidative stress and inflammation induced by strenuous exercise affect glycocalyx integrity and endothelial function. Twenty one young, untrained healthy men performed a maximal incremental cycling exercise - until exhaustion. Markers of glycocalyx shedding (syndecan-1, heparan sulfate and hyaluronic acid), endothelial status (nitric oxide and prostacyclin metabolites - nitrate, nitrite, 6-keto-prostaglandin F(1alpha)), oxidative stress (8-oxo-2'-deoxyguanosine) and antioxidant capacity (uric acid, non-enzymatic antioxidant capacity) as well as markers of inflammation (sVCAM-1 and sICAM-1) were analyzed in venous blood samples taken at rest and at the end of exercise. The applied strenuous exercise caused a 5-fold increase in plasma lactate and hypoxanthine concentrations (p<0.001), a fall in plasma uric acid concentration and non-enzymatic antioxidant capacity (p<10(-4)), accompanied by an increase (p=0.003) in sVCAM-1 concentration. Plasma 6-keto-prostaglandin F(1alpha) concentration increased (p=0.006) at exhaustion, while nitrate and nitrite concentrations were not affected. Surprisingly, no significant changes in serum syndecan-1 and heparan sulfate concentrations were observed. We have concluded, that a single bout of severe-intensity exercise is well accommodated by endothelium in young, healthy men as it neither results in evident glycocalyx disruption nor in the impairment of nitric oxide and prostacyclin production. PMID:26447512

  13. Effect of argan and olive oil consumption on the hormonal profile of androgens among healthy adult Moroccan men.

    Science.gov (United States)

    Derouiche, Abdelfettah; Jafri, Ali; Driouch, Issam; El Khasmi, Mohammed; Adlouni, Ahmed; Benajiba, Nada; Bamou, Youssef; Saile, Rachid; Benouhoud, Mohammed

    2013-01-01

    This study aimed to assess the effect of virgin argan oil (VAO) and extra virgin olive oil (EVO) on the hormonal profile of androgens and anthropometric parameters among healthy adult Moroccan men during a controlled nutritional intervention. The study was carried out on 60 young and healthy male volunteers aged between 23 and 40 years old. During a stabilization period of 2 weeks they consumed butter. The group was then randomized into two categories, the first one consuming VAO and the second EVO for 3 weeks. Testosterone (T), luteinizing hormone (LH) and dehydroepiandrosterone (DHEAS) serum concentrations were measured at the beginning of the study and at the end of each period. The Mann-Whitney test was used to compare the two groups (VAO and EVO) during each step of the study. Differences in androgens and anthropometric parameters between the baseline and after 3 weeks of the diet in the VAO and EVO groups were analyzed using the Wilcoxon test. T and LH serum concentrations significantly increased after the intervention period. T levels increased by 19.9% and 17.4% (p argan or olive oils. The results suggest that consumption of AVO and EVO might be the origin of a positive action on the androgen hormonal profile of men. PMID:23472458

  14. Evaluation of penile erection rigidity in healthy men using virtual touch tissue quantification

    OpenAIRE

    Zheng, Xiaozhi; Ji, Ping; Mao, Hongwei; Wu, Jing

    2012-01-01

    Background The aim of the study was to describe the shear wave velocity (SWV) values of the penis by virtual touch tissue quantification (VTTQ) and to examine the clinical usefulness of this procedure in evaluation of the rigidity changes in penile erection. Patients and methods. VTTQ was performed in 37 healthy volunteers. In the course of erection, SWV values of glans penis, corpus penis and radix penis were quantified and grades of erection were documented. The SWV values at different grad...

  15. Cordyceps militaris Enhances Cell-Mediated Immunity in Healthy Korean Men.

    Science.gov (United States)

    Kang, Ho Joon; Baik, Hyun Wook; Kim, Sang Jung; Lee, Seong Gyu; Ahn, Hong Yup; Park, Ju Sang; Park, Sang Jong; Jang, Eun Jeong; Park, Sang Woon; Choi, Jin Young; Sung, Ji Hee; Lee, Seung Min

    2015-10-01

    Cordyceps militaris is a mushroom traditionally used for diverse pharmaceutical purposes in East Asia, including China, and has been found to be effective for enhancing immunity through various types of animal testing. The aim of this study is to determine the efficacy of C. militaris for enhancing cell-mediated immunity and its safety in healthy male adults. Healthy male adults were divided into the experimental group (n = 39), given 1.5 g/day of ethanol treated C. militaris in capsules, and the control group (n = 40), given the same number of identical placebo capsules filled with microcrystalline cellulose and lactose for 4 weeks from February 13 to March 14, 2012; the natural killer (NK) cell activity, lymphocyte proliferation index (PI), and T-helper cell 1 (Th1) cytokine cluster (interferon [IFN]-γ, interleukin [IL]-12, IL-2, and tumor necrosis factor [TNF]-α) were measured, along with stability test, at weeks 0, 2, and 4. The C. militaris group showed a statistically significant greater increase in NK200 (P = .0010), lymphocyte PI (P ≤ .0001), IL-2 (P = .0096), and IFN-γ (P = .0126), compared with the basal level, than the placebo group. There was no statistically significant adverse reaction. C. militaris enhanced the NK cell activity and lymphocyte proliferation and partially increased Th1 cytokine secretion. Therefore, C. militaris is safe and effective for enhancing cell-mediated immunity of healthy male adults. PMID:26284906

  16. In vivo assessment of forearm bone mass and ulnar bending stiffness in healthy men

    Science.gov (United States)

    Myburgh, K. H.; Zhou, L. J.; Steele, C. R.; Arnaud, S.; Marcus, R.

    1992-01-01

    The cross-sectional bending stiffness EI of the ulna was measured in vivo by mechanical resistance tissue analysis (MRTA) in 90 men aged 19-89 years. MRTA measures the impedance response of low-frequency vibrations to determine EI, which is a reflection of elastic modulus E and moment of inertia I for the whole ulna. EI was compared to conventional estimates of bone mineral content (BMC), bone width (BW), and BMC/BW, which were all measured by single-photon absorptiometry. Results obtained from the nondominant ulna indicate that BW increases (r = 0.27, p = 0.01) and ulnar BMC/BW decreases (r = -0.31, p < or = 0.005) with age. Neither BMC nor EI declined with age. The single best predictor of EI was BW (r2 = 0.47, p = 0.0001), and further small but significant contributions were made by BMC (r2 = 0.53, p = 0.0001) and grip strength (r2 = 0.55, p = 0.0001). These results suggest that the resistance of older men to forearm fracture is related to age-associated changes in the moment of inertia achieved by redistributing bone mineral farther from the bending axis. We conclude that the in vivo assessment of bone geometry offers important insights to the comprehensive evaluation of bone strength.

  17. Comparison of Salivary Antioxidants in Healthy Smoking and Non-smoking Men

    Directory of Open Access Journals (Sweden)

    Hamid-reza Abdolsamadi

    2011-12-01

    Full Text Available Background: Tobacco use is known as a serious global public health problem, and is alsoan important risk factor for oral diseases. Saliva is the first biological medium encountered during inhalation of cigarette smoke. Therefore, the mainaim of this study was to compare the levels of salivary antioxidants betweenhealthy smoking and non-smoking men.Methods: Unstimulated whole saliva samples were collected from 80 men. Forty subjects were smokers with a daily consumption of 20 cigarettes for at least 10years and 40 subjects were non-smokers. The salivary levels of uric acid,superoxide dismutase, glutathione peroxidase, and peroxidase were measured and compared between studied groups.Results: The mean levels of salivary superoxide dismutase, glutathione peroxidase,and peroxidase were significantly lower in smokers than non-smokers. Therewas no statistically significant difference in the salivary uric acid levelbetween smokers and non-smokers.Conclusions:Measurement of antioxidant agents in human saliva might be useful for estimating the level of oxidative stress caused by cigarette smoke

  18. [How healthy are and behave men? Differences in health status and health behavior between the two sexes in the Canton of Zurich].

    Science.gov (United States)

    Hämmig, Oliver; Puhan, Milo A

    2015-09-30

    Men have not been the focus of health monitoring and reporting in German-speaking Switzerland so far and are a largely neglected target group of governmental preventive efforts. Without good reason. Men have a substantial preventive potential regarding health, health behavior and use of health and medical services, as can be seen in the recently published global health report of the Canton Zurich. Men have a shorter life expectancy compared to women and a significantly higher mortality with regard to strongly behavior-related chronic diseases as well as fatal traffic accidents and suicides. Men also show comparably unfavourable health behavior and a reduced utilization of health services. The stronger, but also less healthy and less healthy behaving sex should increasingly be the focus of health reporting and health monitoring in the future. PMID:26422073

  19. Does a healthy lifestyle behaviour influence the prognosis of low back pain among men and women in a general population? A population-based cohort study

    OpenAIRE

    Bohman, Tony; Alfredsson, Lars; Jensen, Irene; Hallqvist, Johan; Vingård, Eva; Skillgate, Eva

    2014-01-01

    OBJECTIVES: To study the influence of healthy lifestyle behaviour on the prognosis of occasional low back pain among men and women in a general population. DESIGN: Cohort study with a 4-year follow-up. SETTINGS: General population in Stockholm County, Sweden. PARTICIPANTS: The study sample comprised 3938 men and 5056 women aged 18-84 from the Stockholm Public Health Cohort reporting occasional low back pain in the baseline questionnaire 2006. MEASURES: Lifestyle factors and potential confound...

  20. The rate of intestinal glucose absorption is correlated with plasma glucose-dependent insulinotropic polypeptide concentrations in healthy men

    DEFF Research Database (Denmark)

    Wachters-Hagedoorn, Renate E; Priebe, Marion G; Heimweg, Janneke A J;

    2006-01-01

    Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) both play a role in the control of glucose homeostasis, and GIP is implicated in the regulation of energy storage. The capacity of carbohydrates to induce secretion of these incretin hormones could be one of the...... factors determining the metabolic quality of different types of carbohydrates. We analyzed the correlation between the rate of intestinal absorption of (starch-derived) glucose and plasma concentrations of GLP-1 and GIP after ingestion of glucose and starchy foods with a different content of rapidly and...... slowly available glucose. In a crossover study, glucose, insulin, GLP-1, and GIP concentrations were monitored for 6 h after consumption of glucose, uncooked cornstarch (UCCS) or corn pasta in 7 healthy men. All test meals were naturally labeled with 13C. Using a primed, continuous D-[6,6-2H2]glucose...

  1. Breakfast meal composition influences plasma tryptophan to large neutral amino acid ratios of healthy lean young men

    International Nuclear Information System (INIS)

    The effect of a carbohydrate, a 20% protein, or a carbohydrate +0.3% tryptophan TRP breakfast on plasma large neutral amino acid ratio was studied in 6 healthy men. The carbohydrate-rich meal produced shifts in plasma amino acid concentrations such that plasma TRP/LNAA ratios increased from 0.13 to 0.15 (p<0.04) and the protein meal decreased the ratio from 0.14 to 0.11 (p<0.04) after 1 hour. Addition of 0.3% TRP to the carbohydrate-rich meal increased plasma TRP/LNAA ratios more than 2-fold. The TRP containing meal was thus the only one likely to influence brain 5-HT synthesis, although the difference between the plasma TRP/LNAA ratios after carbohydrate and protein breakfasts suggests that the brain may distinguish, by synthesizing more or less 5-HT, the composition of breakfast meals. (Author)

  2. Computerized spatial navigation training during 14 days of bed rest in healthy older adult men: Effect on gait performance.

    Science.gov (United States)

    Marusic, Uros; Kavcic, Voyko; Giordani, Bruno; Gerževič, Mitja; Meeusen, Romain; Pišot, Rado

    2015-06-01

    Prolonged physical inactivity or bed rest (BR) due to illness or other factors can result in significant declines in physical health and even cognitive functions. Based on random selection, 7 healthy older adult men received computerized spatial navigation training, while 8 served as active controls during 14-day BR. Greater post-BR declines were seen in normal and complex (dual-task) walking for the control as compared to intervention group, suggesting that computerized spatial navigation training can successfully moderate detrimental BR effects. Findings underline the generalization of cognitive-based intervention to the motor domain and potentially support their use to supplement BR interventions (e.g., exercise and nutrition). PMID:25938245

  3. Effect of hyperbaric oxygen and vitamin C and E supplementation on biomarkers of oxidative stress in healthy men

    DEFF Research Database (Denmark)

    Bader, Nicolle; Bosy-Westphal, Anja; Koch, Andreas; Rimbach, Gerald; Weimann, Allan; Poulsen, Henrik E; Müller, Manfred J

    2007-01-01

    The objectives of the present study were to evaluate the effect of normobaric and hyperbaric O2 (HBO) on plasma antioxidants and biomarkers of oxidative stress in plasma and urine and to investigate the effect of a 4-week vitamin C plus E supplementation on HBO-induced oxidative stress. Nineteen...... healthy men were exposed to HBO (100 % O2; 240 kPa) before and after 4 weeks' supplementation with 500 mg vitamin C plus 165 mg alpha-tocopherol equivalents. Exposure to 21 % O2 at 100 kPa served as intra-individual controls (control). Samples for the analysis of plasma antioxidants and oxidative stress......G) excretion (P = 0.006). Oxidative stress was not prevented by a 4-week supplementation with vitamins C and E. HBO-induced changes in plasma parameters correlated with basal antioxidant levels. The increase of urinary 8-oxodG after HBO plus supplementation correlated negatively with vitamin E intake (P = 0...

  4. PFOS (perfluorooctanesulfonate) in serum is negatively associated with testosterone levels, but not with semen quality, in healthy men

    DEFF Research Database (Denmark)

    Joensen, Ulla Nordström; Veyrand, Bruno; Antignac, Jean-Philippe; Blomberg Jensen, Martin; Petersen, Jørgen Holm; Marchand, Philippe; Skakkebæk, Niels Erik; Andersson, Anna-Maria; Le Bizec, Bruno; Jørgensen, Niels

    2013-01-01

    Agency (MST-621-00013), and Kirsten and Freddy Johansen Foundation (grant no. 95-103-72087). The funding organizations played no role in the design and conduct of the study, in collection, management, analysis and interpretation of the data; or in the presentation, review or approval of the manuscript......Is exposure to perfluorinated compounds (PFCs) associated with testicular function (reproductive hormone levels and semen quality) in healthy men? SUMMARY ANSWER: PFOS levels were significantly negatively associated with serum testosterone (total and calculated free), but not with any other...... reproductive hormones or semen quality. WHAT IS KNOWN ALREADY: In animals, some PFCs have endocrine disrupting potential, but few studies have investigated PFCs in relation to human testicular function. Previously, we and others have observed a negative association between serum PFC levels and sperm morphology...

  5. Antioxidant effects of D-004, a lipid extract from the Roystonea regia fruit, on the plasma of healthy men

    Institute of Scientific and Technical Information of China (English)

    Emesto López; Vivian Molina; José Illnait; Ambar Oyarzábal; Lilia C.Fernández; Rosa Más; Rafael Gámez; Julio C.Fernández; Sonia Jiménez; Meilis Mesa; Ivón Hollands; Sarahí Mendoza

    2009-01-01

    The aim of thisstudy was to conduct a randomized, double-blind and placebo-controlled study to investigate the effects of D-004, a lipid extract of the Roystonea regia fruit that prevents testosterone- and phenylepinephrine-induced prostate hyperplasia in rodents, on plasma oxidative markers in healthy men. We enrolled male volunteers (20-55 years) in good health and without lower urinary tract symptoms. Thirty-four eligible participants were randomized to placebo or D-004 (320 mg) capsules administered daily for 6 weeks. An interim check-up and a final visit were conducted after 3 and 6 weeks of therapy, respectively. Physical examinations were performed at each visit, and laboratory tests were performed at baseline and at treatment completion. Oxidative variables included plasma malondiaidehyde (MDA), total hydroxyperoxides (TOH), sulphydryl (SH) groups and total antioxidant status (TAS). We assessed treatment compliance and addressed adverse experiences (AEs) at weeks 3 and 6. At week 6, with D-004, the mean reductions of plasma MDA (26.7%), TOH (18.8%) and SH groups (31.6%), and the mean increase of TAS (35.3%) were significantly different from those of placebo (P<0.001 for plasma TAS, P<0.0001 for all other comparisons). D-004 did not differ from the placebo in safety indicators. There were two withdrawals (both in the D-004 group), with one due to dyspepsia (the only AE during the trial). In conclusion, D-004 displayed antioxidant effects on plasma oxidative markers in healthy men, which was consistent with findings from laboratory experimental studies.

  6. Intentional weight loss and mortality among initially healthy men and women

    DEFF Research Database (Denmark)

    Simonsen, Mette K; Hundrup, Yrsa A; Obel, Erik B;

    2008-01-01

    increased mortality observed with weight loss must depend on confounding or poor study designs. This review was conducted to summarize results from studies on intentional weight loss and mortality among healthy individuals, while carefully considering the designs and problems in these studies. Evaluation...... criteria with a rating scale were developed. Of the studies evaluated, two found decreased mortality with intentional weight loss, three found increased mortality, and four found no significant associations between intentional weight loss and total mortality. Thus, it is still not possible for health...... authorities to make secure recommendations on intentional weight loss. More studies designed to specifically address this issue are warranted....

  7. Gastrin radioimmunoassay : serum levels in healthy men and patients with chronic duodenal ulcer

    International Nuclear Information System (INIS)

    With a homologous double antibody radioimmunoassay, fasting serum gastrin was measured in 35 healthy subjects and 21 patients of chronic duodenal ulcer. The assay was highly reproducible with the inter- and intra-assay coefficient of variations not exceeding 12 percent and 8 percent respectively. The fasting serum gastrin (Mean +- SE) in duodenal ulcer patients was 86.1 +- 13.9 pg/ml. This was significantly higher ( P < 0.05) when compared to the mean value of control group (36.4 +- 6.5 pg/ml). The exact significance of higher fasting serum gastrin in duodental ulcer patients is not well understood. (auth.)

  8. Test-retest reliability of the net joint power transferred by the lower limbs during walking in healthy men

    Directory of Open Access Journals (Sweden)

    Daniel Jandačka

    2013-09-01

    Full Text Available OBJECTIVE: To determine the reliability of the measurement of net joint power during repeated gait measurements within one day and between two different measurement days. METHODS: Thirty able-bodied men who underwent repeated gait measurements within a day and between days participated in this research. An acceptable trial was one in which the participant complied with the range of walking speed 1.45 m/s ± 5%. Three-dimensional angles, angular velocities, net moments of force and net power for the ankle, knee and hip joints were determined using external passive reflective markers, an 8-camera motion analysis system and two force plates. RESULTS: This study presents the patterns of the net power in the fundamental joints of the lower limbs in young healthy men at standard gait velocity. Intraclass correlation coefficients for net joint power measure reached values in the range of .70 to .89 on the first day, from .69 to .86 on the second day, and from .67 to .83 in total. CONCLUSION: The reliability of the measurement of the peak net joint power within one day and between the two measurement days was evaluated as satisfactory. The study provides the value of minimal detectable change for the peak net power of the lower limb in the sagittal plane during gait. The net joint power appears to be a reliable measure and could be used in practice.

  9. HPV Population Profiling in Healthy Men by Next-Generation Deep Sequencing Coupled with HPV-QUEST.

    Science.gov (United States)

    Yin, Li; Yao, Jin; Chang, Kaifen; Gardner, Brent P; Yu, Fahong; Giuliano, Anna R; Goodenow, Maureen M

    2016-02-01

    Multiple-type human papillomaviruses (HPV) infection presents a greater risk for persistence in asymptomatic individuals and may accelerate cancer development. To extend the scope of HPV types defined by probe-based assays, multiplexing deep sequencing of HPV L1, coupled with an HPV-QUEST genotyping server and a bioinformatic pipeline, was established and applied to survey the diversity of HPV genotypes among a subset of healthy men from the HPV in Men (HIM) Multinational Study. Twenty-one HPV genotypes (12 high-risk and 9 low-risk) were detected in the genital area from 18 asymptomatic individuals. A single HPV type, either HPV16, HPV6b or HPV83, was detected in 7 individuals, while coinfection by 2 to 5 high-risk and/or low-risk genotypes was identified in the other 11 participants. In two individuals studied for over one year, HPV16 persisted, while fluctuations of coinfecting genotypes occurred. HPV L1 regions were generally identical between query and reference sequences, although nonsynonymous and synonymous nucleotide polymorphisms of HPV16, 18, 31, 35h, 59, 70, 73, cand85, 6b, 62, 81, 83, cand89 or JEB2 L1 genotypes, mostly unidentified by linear array, were evident. Deep sequencing coupled with HPV-QUEST provides efficient and unambiguous classification of HPV genotypes in multiple-type HPV infection in host ecosystems. PMID:26821041

  10. Impact of single-dose nandrolone decanoate on gonadotropins, blood lipids and HMG CoA reductase in healthy men.

    Science.gov (United States)

    Gårevik, N; Börjesson, A; Choong, E; Ekström, L; Lehtihet, M

    2016-06-01

    The aim was to study the effect and time profile of a single dose of nandrolone decanoate (ND) on gonadotropins, blood lipids and HMG CoA reductase [3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR)] in healthy men. Eleven healthy male participants aged 29-46 years were given a single dose of 150 mg ND as an intramuscular dose of Deca Durabol®, Organon. Blood samples for sex hormones, lipids and HMGCR mRNA analysis were collected prior to ND administration day 0, 4 and 14. A significant suppression of luteinising hormone (LH) and follicle-stimulating hormone (FSH) was seen after 4 days. Total testosterone and bioavailable testosterone level decreased significantly throughout the observed study period. A small but significant decrease in sexual hormone-binding globulin (SHBG) was seen after 4 days but not after 14 days. Total serum (S)-cholesterol and plasma (P)-apolipoprotein B (ApoB) increased significantly after 14 days. In 80% of the individuals, the HMGCR mRNA level was increased 4 days after the ND administration. Our results show that a single dose of 150 mg ND increases (1) HMGCR mRNA expression, (2) total S-cholesterol and (3) P-ApoB level. The long-term consequences on cardiovascular risk that may appear in users remain to be elucidated. PMID:26370185

  11. The structure of wheat bread influences the postprandial metabolic response in healthy men

    DEFF Research Database (Denmark)

    Eelderink, Coby; Noort, Martijn W J; Sozer, Nesli; Koehorst, Martijn; Holst, Jens J; Deacon, Carolyn F; Rehfeld, Jens F; Poutanen, Kaisa; Vonk, Roel J; Oudhuis, Lizette; Priebe, Marion G

    2015-01-01

    Postprandial high glucose and insulin responses after starchy food consumption, associated with an increased risk of developing several metabolic diseases, could possibly be improved by altering food structure. We investigated the influence of a compact food structure; different wheat products with...... a similar composition were created using different processing conditions. The postprandial glucose kinetics and metabolic response to bread with a compact structure (flat bread, FB) was compared to bread with a porous structure (control bread, CB) in a randomized, crossover study with ten healthy...... male volunteers. Pasta (PA), with a very compact structure, was used as the control. The rate of appearance of exogenous glucose (RaE), endogenous glucose production, and glucose clearance rate (GCR) was calculated using stable isotopes. Furthermore, postprandial plasma concentrations of glucose...

  12. Factor analysis of regional cerebral glucose metabolic rates in healthy men

    International Nuclear Information System (INIS)

    Cerebral glucose utilization measured with fluorine-18-fluoro-2-deoxy-D-glucose is characterized by considerable variability both among different persons and for the same person examined on different occasions. The goal of this study was to explore whether some regions of the brain were more variable than others with respect to glucose utilization and whether there was a pattern in their covariance. The global and regional cerebral utilization of glucose was measured in 12 healthy young volunteers on 3 or 4 occasions. In all, 24 regions were examined. The interrelation of the glucose utilization rates of the brain regions was investigated by factor analysis of the metabolic rates. Some 70% of the total variance was attributable to only 1 factor, while 80% of the total variance could be attributed to 2 factors. Regions making up the first factor were the frontal and temporal cortex, cingulate gyrus, caudate nucleus, thalamus and putamen. These regions are functionally related to the limbic system. Regions of the second factor were the parietal cortex, occipital cortex and cerebellum, regions more clearly related to sensory and motor functions. The 2-factor pattern was highly reproducible, being found with different algorithms for factor extraction and rotation. Under resting conditions, the variance of cerebral metabolism seems to be primarily related to regions which are closely involved with the limbic system. Cortical regions involved primarily in motor and sensory functions have less influence on the variance. (orig.)

  13. [Psychological and physiological effects of a 5-week ergometer training in healthy young men (author's transl)].

    Science.gov (United States)

    Myrtek, M; Villinger, U

    1976-09-24

    40 healthy male students were randomly assigned to either the exercise or control group. The latter was asked not to alter their common physical activity while the exercise group trained three times weekly on the bicycle ergometer for 15 minutes with a constant heart rate of 140bpm. At the beginning and after five weeks physiological data comprising cardiovascular and pulmonary responses at rest and under submaximal ergometric exercise were assessed. Additional data included psychological achievement tests, self reports of personality dimensions and frequency of physical complaints. Results indicated a marked increase in physical fitness for the training group improving the work load from 158 watt to 197 watt at constant heart rate. At rest and especially at submaximal work load there was an improvement of the economy of the cardiovascular and respiratory system. Contrary to these findings there were no changes or impairment in the psychological achievement tests, measuring concentration. Compared with the control group self reports of personality dimensions did not change except for a tendency to more extrovert behavior in the exercise group. Unexpectedly, the frequency of physical complaints did not decrease. The reason for this discrepancy is discussed. PMID:979871

  14. Creatine supplementation does not enhance submaximal aerobic training adaptations in healthy young men and women.

    Science.gov (United States)

    Reardon, T F; Ruell, P A; Fiatarone Singh, M A; Thompson, C H; Rooney, K B

    2006-10-01

    The benefits of dietary creatine supplementation on muscle performance are generally related to an increase in muscle phosphocreatine content. However, creatine supplementation may benefit endurance sports through increased glycogen re-synthesis following exercise. This study investigated the effect of creatine supplementation on muscle glycogen content, submaximal exercise fuel utilisation and endurance performance following 4 weeks of endurance training. Thirteen healthy, physically active, non-vegetarian subjects volunteered to take part and completed the study. Subjects were supplemented with either creatine monohydrate (CREAT, n = 7) or placebo-maltodextrin (CON, n = 6). Submaximal fuel utilisation and endurance performance were assessed before and after a 4 week endurance training program. Muscle biopsies were also collected before and following training for assessment of muscle creatine and glycogen content. Training increased quadriceps glycogen content to the same degree (approximately 20%) in both groups (P = 0.04). There was a significant training effect on submaximal fuel utilisation and improved endurance performance. However, there was no significant treatment effect of creatine supplementation. Creatine supplementation does not effect metabolic adaptations to endurance training. PMID:16896727

  15. Diet Rich in Saturated Fat Decreases the Ratio of Thromboxane/prostacyclin in Healthy Men

    Institute of Scientific and Technical Information of China (English)

    DUO LI; RAYMUNDO HABITO; GEORGE ANGELOS; ANDREW J. SINCLAIR; MADELEINE J. BALL

    2003-01-01

    Objective To investigate the effect of dietary saturated fat (SFA) from animal sources on the urine excretion 11-dehydro thromboxane B2 (TXB2) and 6-keto prostaglandin F 1α (PGF 1α) in 27 healthy free-living male subjects aged 30 to 55 years. Methods It was a randomized crossover design. Each volunteer was randomly assigned to one of the two diets (high fat and low fat) for a period of 4 weeks, after which each subject resumed his usual diet for 2 weeks as a ‘wash-out period',before being assigned to the other diet for an additional 4 weeks. Results Serum proportion of 20:4n-6 was 5% lower in the high fat (6.2% of total fatty acid) than in the low fat diet (6.5% of total fatty acid), which was associated with a significantly decreased ratio of the urinary excretion 11-dehydro TXB2 to 6-keto PGF 1α (P<0.05). However, there was no significant fall in the absolute urinary excretion of 11-dehydro TXB2. Conclusions Diet rich in SFA from animal sources may influence TXA2 formation via effect on tissue proportion of 20:4n-6.

  16. Helplessness and perceived pain intensity: relations to cortisol concentrations after electrocutaneous stimulation in healthy young men

    Directory of Open Access Journals (Sweden)

    Müller Matthias J

    2011-06-01

    Full Text Available Abstract Background Uncontrollable aversive events are associated with feelings of helplessness and cortisol elevation and are suitable as a model of depression. The high comorbidity of depression and pain symptoms and the importance of controllability in both conditions are clinically well-known but empirical studies are scarce. The study investigated the relationship of pain experience, helplessness, and cortisol secretion after controllable vs. uncontrollable electric skin stimulation in healthy male individuals. Methods Sixty-four male volunteers were randomly assigned to receive 30 controllable (self-administered or uncontrollable (experimenter-administered painful electric skin stimuli. Perceived pain intensity (PPI, subjective helplessness ratings, and salivary cortisol concentrations were assessed. PPI was assessed after stress exposure. For salivary cortisol concentrations and subjective helplessness ratings, areas under the response curve (AUC were calculated. Results After uncontrollable vs. controllable stress exposure significantly higher PPI ratings (P = 0.023, higher subjective helplessness AUC (P Conclusions The results confirm the impact of uncontrollability on stress responses in humans; the relationship of PPI with subjective helplessness and salivary cortisol suggests a cognitive-affective sensitization of pain perception, particularly under uncontrollable conditions.

  17. Are Healthy Diets that follow The 2005 Dietary Guidelines for Americans (DGA) associated with Bone Mineral Density (BMD) in men and women?

    Science.gov (United States)

    The 2005 DGA is a government promulgated healthy dietary pattern to reduce the risk of chronic diseases, including osteoporosis. We examined whether a diet consistent with the DGA was associated with higher BMD in men and women of the Framingham Offspring Study (FOS). We developed an index to measur...

  18. HDL particle size and the risk of coronary heart disease in apparently healthy men and women: The EPIC-Norfolk prospective population study

    NARCIS (Netherlands)

    B.J. Arsenault; I. Lemieux; J.P. Després; P. Gagnon; N.J. Wareham; E.S.G. Stroes; J.J.P. Kastelein; K.T. Khaw; S.M. Boekholdt

    2009-01-01

    Objective: To evaluate the association between HDL particle size measured by gradient gel electrophoresis and risk of incident coronary heart disease (CHD) in apparently healthy men and women. Methods: We performed a prospective case-control study nested in the EPIC-Norfolk cohort. Cases were appare

  19. Serum γ-glutamyltransferase, alanine aminotransferase, and aspartate aminotransferase activity in Iranian healthy blood donor men

    Institute of Scientific and Technical Information of China (English)

    Hossein Khedmat; Nasrin Zarei; Farahnaz Fallahian; Hassan Abolghasemi; Bashir Hajibeigi; Zohre Attarchi; Farshid Alaeddini; Mohammad Taghi Holisaz; Masoumeh Pourali; Shahin Sharifi

    2007-01-01

    AIM: To determine serum γ-glutamyltransferase (GGT), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) activity, and to assess their correlation with demographic and clinical findings in healthy blood donors.METHODS: This cross-sectional study was performed in 934 male blood donors, aged 18 to 68 years, who consecutively attended Tehran blood transfusion service in 2006. All participants were seronegative for HBV or HCV infections, non alcohol users, and all underwent a standard interview and anthropometric tests. Clinical and biochemical parameters including AST, ALT, and GGT activities were determined. Patients taking drugs known to cause hepatic fat deposition were excluded. For AST, ALT, and GGT variables, we used 33.33 and 66.66 percentiles, so that each of them was divided into three tertiles.RESULTS: Mean AST, ALT, and GGT activities were 25.26 ± 12.58 U/L (normal range 5-35 U/L), 33.13 ± 22.98 (normal range 5-35 U/L), and 25.11 ± 18.32 (normal range 6-37 U/L), respectively. By univariate analyses, there were significant associations between increasing AST, ALT, or GGT tertiles and age, body weight, body mass index, and waist and hip circumferences (P < 0.05). By multiple linear regression analyses, ALT was found to be positively correlated with dyslipidemia (B = 6.988, P = 0.038), whereas ALT and AST were negatively correlated with age. AST, ALT, and GGT levels had positive correlation with family history of liver disease (B = 15.763, P < 0.001), (B = 32.345, P < 0.001), (B =24.415, P < 0.001), respectively.CONCLUSION: Although we did not determine the cutoffs of the upper normal limits for AST, ALT, and GGT levels, we would suggest screening asymptomatic patients with dyslipidemia and also subjects with a family history of liver disease.

  20. EFFECT OF ACUTE HYPOXIA ON POST-EXERCISE PARASYMPATHETIC REACTIVATION IN HEALTHY MEN

    Directory of Open Access Journals (Sweden)

    Hani eAl Haddad

    2012-07-01

    Full Text Available In this study we assessed the effect of acute hypoxia on post-exercise parasympathetic reactivation inferred from heart rate (HR recovery (HRR and HR variability (HRV indices. Ten healthy males participated in this study. Following 10 min of seated rest, participants performed 5 min of submaximal running at the speed associated with the first ventilatory threshold (Sub followed by a 20-s all-out supramaximal sprint (Supra. Both the Sub and Supra runs were immediately followed by 15 min of seated passive recovery. The resting and exercise sequence were performed in both normoxia (N and normobaric hypoxia (H (FiO2 = 15.4%. HRR indices (e.g., heart beats recovered in the first minute after exercise cessation, HRR60s and vagal-related HRV indices (i.e., natural logarithm of the square root of the mean of the sum of the squared differences between adjacent normal R-R intervals (Ln rMSSD were calculated for both conditions. Difference in the changes between N and H for all HR-derived indices were also calculated for both Sub and Supra. HRR60s was greater in N compared with H following Sub only (60±14 vs. 52±19 beats.min-1, P = 0.016. Ln rMSSD was greater in N compared with H (post Sub: 3.60±0.45 vs. 3.28±0.44 ms in N and H, respectively and post Supra: 2.66±0.54 vs. 2.65±0.63 ms, main condition effect P = 0.02. When comparing the difference in the changes, hypoxia decreased HRR60s (-14.3%±17.2 vs. 5.2-0.5%±19.3; following Sub and Supra, respectively; P = 0.03 and Ln rMSSD (-8.6%±7.0 vs. 2.0%±13.3, following Sub and Supra, respectively; P = 0.08, Cohen’s effect size = 0.62 more following Sub than Supra. While hypoxia may delay parasympathetic reactivation following submaximal exercise, its effect is not apparent following supramaximal exercise. This may suggest that the effect of blood O2 partial pressure on parasympathetic reactivation is limited under heightened sympathetic activation.

  1. Effect of recombinant human erythropoietin treatment on blood pressure and some haematological parameters in healthy men.

    Science.gov (United States)

    Berglund, B; Ekblom, B

    1991-02-01

    The aim of this study was to evaluate the effect of treatment with subcutaneous injections of recombinant human erythropoietin (rhEpo), 20-40 IU kg-1 body weight, 3 times a week, on resting blood pressure, blood pressure response during submaximal exercise, some haematological parameters, and subjective side-effects in 15 healthy male subjects. RhEpo increased both haemoglobin (Hb) concentration and haematocrit (Hct) significantly, the values for Hb being 152 +/- 4.2 g l-1 before treatment and 169 +/- 9.3 g l-1 (mean values +/- SD) after 6 weeks of rhEpo treatment (P less than 0.001). The corresponding values for Hct were 44.5 +/- 1.5% and 49.7 +/- 1.9% (P less than 0.001), respectively. The systolic and diastolic blood pressure values at rest were unchanged after rhEpo treatment. A marked increase in systolic blood pressure was observed during submaximal exercise at 200 W, the initial and final values being 177 +/- 14.2 mmHg and 191 +/- 19.5 mmHg (P less than 0.01), respectively. Heart rate during exercise at 200 W was significantly lower after rhEpo treatment than before it: 144 +/- 15 beats min-1 compared to 136 +/- 8 beats min-1 (P less than 0.001). The leucocyte count remained unchanged after rhEpo treatment, but there was a significant decrease (P less than 0.05) in the number of lymphocytes. Reticulocyte and platelet counts were unchanged. Serum (S) ferritin decreased from 87.3 +/- 41.8 mmol l-1 to 59.3 +/- 27.8 mmol l-1 after rhEpo treatment (P less than 0.001). Serum-Na, S-K, S-Ca, S-creatinine, S-bilirubin, S-aspartate aminotransferase (ASAT), S-alanine aminotransferase (ALAT), and S-lactate dehydrogenase (LD) were unchanged after rhEpo treatment. No subjective side-effects were reported. In conclusion, low doses of rhEpo increased Hb levels and Hct by more than 10% after 6 weeks. Blood pressure at rest was unchanged, but rhEpo induced a markedly accentuated blood pressure reaction during exercise. A minor decrease in the lymphocyte count was observed

  2. Effect of acute dietary nitrate intake on maximal knee extensor speed and power in healthy men and women.

    Science.gov (United States)

    Coggan, Andrew R; Leibowitz, Joshua L; Kadkhodayan, Ana; Thomas, Deepak P; Ramamurthy, Sujata; Spearie, Catherine Anderson; Waller, Suzanne; Farmer, Marsha; Peterson, Linda R

    2015-08-01

    Nitric oxide (NO) has been demonstrated to enhance the maximal shortening velocity and maximal power of rodent muscle. Dietary nitrate (NO3(-)) intake has been demonstrated to increase NO bioavailability in humans. We therefore hypothesized that acute dietary NO3(-) intake (in the form of a concentrated beetroot juice (BRJ) supplement) would improve muscle speed and power in humans. To test this hypothesis, healthy men and women (n = 12; age = 22-50 y) were studied using a randomized, double-blind, placebo-controlled crossover design. After an overnight fast, subjects ingested 140 mL of BRJ either containing or devoid of 11.2 mmol of NO3(-). After 2 h, knee extensor contractile function was assessed using a Biodex 4 isokinetic dynamometer. Breath NO levels were also measured periodically using a Niox Mino analyzer as a biomarker of whole-body NO production. No significant changes in breath NO were observed in the placebo trial, whereas breath NO rose by 61% (P < 0.001; effect size = 1.19) after dietary NO3(-) intake. This was accompanied by a 4% (P < 0.01; effect size = 0.74) increase in peak knee extensor power at the highest angular velocity tested (i.e., 6.28 rad/s). Calculated maximal knee extensor power was therefore greater (i.e., 7.90 ± 0.59 vs. 7.44 ± 0.53 W/kg; P < 0.05; effect size = 0.63) after dietary NO3(-) intake, as was the calculated maximal velocity (i.e., 14.5 ± 0.9 vs. 13.1 ± 0.8 rad/s; P < 0.05; effect size = 0.67). No differences in muscle function were observed during 50 consecutive knee extensions performed at 3.14 rad/s. We conclude that acute dietary NO3(-) intake increases whole-body NO production and muscle speed and power in healthy men and women. PMID:25199856

  3. Evaluation of small-bowel transit for solid and liquid test meal in healthy men and women

    Energy Technology Data Exchange (ETDEWEB)

    Bennink, R.; Maegdenbergh, V. van den; De Roo, M.; Mortelmans, L. [Katholieke Univ. Leuven (Belgium). Dept. of Nuclear Medicine; Peeters, M.; Geypens, B.; Rutgeerts, P. [Katholieke Univ. Leuven (Belgium). Dept. of Gastroenterology

    1999-12-01

    Evaluation of severe functional gastrointestinal motility disorders requires an investigation of the entire gastrointestinal tract. This should be possible with a single radionuclide imaging study. The purpose of this study was (1) to define normal values of small-bowel transit in men and women and (2) to assess a possible difference between gender or test meal, since it has been shown that women have slower gastric emptying than men, and gastric emptying of solids is slower than liquids. A standard gastric-emptying test for a solid (technetium-99m sulphur colloids, 230 Kcal) and liquid (indium-111 DTPA water) test meal was performed in 12 healthy male and 12 healthy female volunteers. After 135 min, the volunteer was place in the supine position for static imaging of the abdomen every 15 min for 6 h. Decay and crossover-corrected geometric mean gastric-emptying data were fit to a modified power exponential function to determine the 10% stomach emptying time for solids and liquids separately. An ROI was drawn around the caecum and ascending colon to determine the arrival time of at least 10% of the solid and liquid test meal. Ten percent small-bowel transit time (10% SBTT) and orocaecal transit time (OCTT) were calculated. The OCTT for males and females, respectively for solids and liquids, are 294.6{+-}18.8; 301.3{+-}24.5; 294.6{+-}18.8 and 301.3{+-}24.5 min. The 10% SBTT for males and females, respectively for solids and liquids, are 280.3{+-}18.4; 280.6{+-}24.0; 288.2{+-}18.9 and 297.4{+-}24.4 (means{+-}SEM) min. We observed a simultaneous transfer of solids and liquids from the terminal ileum to caecum (correlation coefficient 0.90). There is no statistically significant difference in SBTT between gender or solids and liquids. In contrast to the gastric-emptying time, the SBTT of solids and liquids were not significantly different nor was a gender difference found. Determination of the OCTT seems to be the simplest and most accurate approach to measure SBTT

  4. Plasma Growth Hormone and Prolactin Levels in Healthy Sedentary Young Men after Short-Term Endurance Training under Hot Environment

    Directory of Open Access Journals (Sweden)

    İbrahim Cicioglu

    2013-09-01

    Full Text Available Pituitary hormones play an important role energy expenditure and body temperature regulation during exercise. The aim of the stu¬dy was to investigate the effect of two different endurance training in ambient temperature (30.76 ± 1.71oC and 57.92 ± 5.80% r.h. on plasma growth hormone (GH and prolactin (PRL levels in non-trained healthy subjects. Twenty-four untrained healthy men participated in an 8-wk progressive two different endurance-training program. Subjects were divided into two groups: an in¬ter¬val running group (IR, and continuous running group (CR. Both groups were performed 3 days/wk. Growth hormone, PRL and VO2max levels were assessed at the beginning and the end of the training period. Body temperature (TB was also measured at the be¬ginning and immediately after each training. The exercise type affected plasma PRL (8.52 vs. 6.50 ng/ml IR and CT groups, P 0.38. Plasma GH level at the end of training pro¬gram increased from 0.42 to 1.48 ng/ml and 0.58 to 0.67 ng/ml for IR and CR groups. Expectedly, both training types increased TB, at a greater rate for IR group than CR group. In conclusion, an 8-wk regular exercise result in an increase in plasma PRL level, with¬out altering plasma GH level, which accompanied by elevated body temperature, regardless of the individual’s sporting rou¬ti¬ne. These suggest that untrained individuals could benefit from a regular exercise program as much as those doing the routine sport.

  5. The Healthy Young Men’s Study: Sampling Methods to Recruit a Random Cohort of Young Men Who Have Sex with Men

    OpenAIRE

    Ford, Wesley L.; Weiss, George; Kipke, Michele D.; Ritt-Olson, Anamara; Iverson, Ellen; Lopez, Donna

    2009-01-01

    Recruiting a scientifically sound cohort of young men who have sex with men (YMSM) is an enduring research challenge. The few cohort studies that have been conducted to date on YMSM have relied on non-probability sampling methods to construct their cohorts. While these studies have provided valuable information about HIV risk behaviors among YMSM, their generalizability to broader YMSM populations is limited.

  6. A comparative pharmacokinetic and pharmacodynamic study of FSK0808 versus reference filgrastim after repeated subcutaneous administration in healthy Japanese men.

    Science.gov (United States)

    Matsuguma, Kyoko; Matsuki, Shunji; Sakamoto, Kei; Shiramoto, Masanari; Nakagawa, Misato; Kimura, Miyuki; Irie, Shin; Kaneko, Daiki; Ohnishi, Akihiro

    2015-03-01

    FSK0808, a biosimilar of filgrastim, is a recombinant human granulocyte colony-stimulating factor developed by Fuji Pharmaceuticals and Mochida Pharmaceutical Co., Ltd. We conducted a double-blind, randomized, crossover study in healthy Japanese men, comparing the number of CD34-positive cells (CD34(+) cells) after repeated subcutaneous administration of either FSK0808 or the reference filgrastim (Gran(®) ). As primary endpoints, we compared the maximum number of CD34(+) cells (CD34(+)  Cmax ) and the time to reach CD34(+) Cmax (CD34(+) tmax ). As secondary endpoints, we compared the area under the curve for the number of CD34(+) cells over time at the 410 hours time point (CD34(+) AUC0-410 ), the parameters used to calculate the pharmacodynamic index of the absolute neutrophil count, and the pharmacokinetic parameters. Regarding the CD34(+) Cmax and the CD34(+) AUC0-410 values, the 95% confidence interval (CI) of the differences between the mean values for each drug was within the range of log(0.8)-log(1.25). With respect to the differences in the median values between drugs, the ratio against the reference filgrastim median value in the 95% CI was within the range of ± 0.2 for the CD34(+) tmax value. From these results, we considered that these drugs display equivalent pharmacodynamic and pharmacokinetic properties. PMID:27128214

  7. Interaction of mealtime ad libitum beverage and food intake with meal advancement in healthy young men and women.

    Science.gov (United States)

    El Khoury, Dalia; Panahi, Shirin; Luhovyy, Bohdan L; Douglas Goff, H; Harvey Anderson, G

    2015-05-01

    The objective of this study was to describe the interaction of beverage and food intake with meal advancement in healthy adults. In a randomized controlled study, 29 men and women consumed to satiation, over 20 min, a pizza meal with one of the five beverages including water, 1% milk, orange juice, regular cola and diet cola. Mealtime food and fluid intake were measured, within each of three 7-min phases of the meal. A progressive decline occurred from phase 1 to 3 in fluid intake and food intake, averaging 59 mL and 268 kcal (P < 0.0001) respectively; however, the relative intake of fluid to food (mL/kcal) increased (P < 0.0001). Beverage type was not a factor. All beverages resulted in similar fluid volume intake compared to water. However, caloric beverages led to higher mealtime total energy intake compared to water (P < 0.001) and diet cola (P < 0.0001). Baseline thirst correlated positively with both fluid (r = 0.28; P < 0.001) and food (r = 0.16; P < 0.05) intakes at the meal, whereas baseline appetite associated positively only with mealtime food intake (r = 0.23; P<0.01). In conclusion, mealtime fluid and food intakes interact, unaffected by beverage characteristics, to increase the ratio of fluid to food intake with meal progression. PMID:25700893

  8. The effect of mannan-binding lectin variant alleles on coronary artery reactivity in healthy young men.

    Science.gov (United States)

    Aittoniemi, Janne; Fan, Yue-Mei; Laaksonen, Reijo; Janatuinen, Tuula; Vesalainen, Risto; Nuutila, Pirjo; Knuuti, Juhani; Hulkkonen, Janne; Hurme, Mikko; Lehtimäki, Terho

    2004-11-01

    Mannan-binding lectin (MBL) is a serum acute-phase protein and a complement component secreted by the liver. Its deficiency caused by point mutations in the MBL gene has recently been associated with severe atherosclerosis. In this study, we investigated the effect of MBL variant alleles on coronary artery reactivity, which is an early marker of coronary dysfunction and predicts the development of atherosclerosis and coronary artery disease. The study population consisted of 51 apparently healthy, normo- or mildly hypercholesterolemic young men. Myocardial blood flow was measured at baseline and during adenosine-induced hyperemia with positron emission tomography (PET), and MBL genotyping was performed using restriction fragment-length polymorphism. As a result, MBL variant alleles had no effect on coronary artery reactivity. This finding suggests that MBL deficiency is not an independent risk factor for coronary dysfunction and early atherogenic changes but rather a co-factor in the development of atherosclerosis. Thus, the connection of MBL variant alleles with environmental risk factors in atherosclerosis should further be assessed. PMID:15458704

  9. Inspiratory and expiratory pulmonary CT: change of bronchial and accompanying pulmonary arterial diameter during respiration in healthy adult men

    International Nuclear Information System (INIS)

    To evaluate changes in the diameter of bronchi and pulmonary arteries during respiration. The ratio of the diameter of matched inner bronchi and accompanying pulmonary arteries was calculated from full inspiration and expiration HRCT of healthy men. In 106 pairs of matched bronchi and pulmonary arteries, the bronhchial-arterial ratios were0.61 ±0.18(upper lung), 0.72±0.21(lower lung), and 0.65±0.20(total) at full inspiration and 0.51±0.32(upper lung), 0.52±0.15(lower lung), and 0.51±0.26(total) at full expiration HRCT, denotiong a statistically significant increase in bronchial diameter of the entire lung at full inspiration. The inner diameter of the bronchus was larger than the diameter of the accompanying pulmonary artery by 0.1% at full expiration and 8.5% at full inspiration. The result of this study would be helpful in understanding the physiology of the lung during respiration

  10. Healthy Men - Quiz

    Science.gov (United States)

    ... Task Force Improving Primary Care Practice Health IT Integration Health Care/System Redesign Clinical-Community Linkages Care Coordination Capacity Building Behavioral and Mental Health Self-Management Support Resources Clinical Community Relationships ...

  11. Endocrine determinants of changes in insulin sensitivity and insulin secretion during a weight cycle in healthy men.

    Directory of Open Access Journals (Sweden)

    Judith Karschin

    Full Text Available Changes in insulin sensitivity (IS and insulin secretion occur with perturbations in energy balance and glycemic load (GL of the diet that may precede the development of insulin resistance and hyperinsulinemia. Determinants of changes in IS and insulin secretion with weight cycling in non-obese healthy subjects remain unclear.In a 6wk controlled 2-stage randomized dietary intervention 32 healthy men (26±4y, BMI: 24±2kg/m2 followed 1wk of overfeeding (OF, 3wks of caloric restriction (CR containing either 50% or 65% carbohydrate (CHO and 2wks of refeeding (RF with the same amount of CHO but either low or high glycaemic index at ±50% energy requirement. Measures of IS (basal: HOMA-index, postprandial: Matsuda-ISI, insulin secretion (early: Stumvoll-index, total: tAUC-insulin/tAUC-glucose and potential endocrine determinants (ghrelin, leptin, adiponectin, thyroid hormone levels, 24h-urinary catecholamine excretion were assessed.IS improved and insulin secretion decreased due to CR and normalized upon RF. Weight loss-induced improvements in basal and postprandial IS were associated with decreases in leptin and increases in ghrelin levels, respectively (r = 0.36 and r = 0.62, p<0.05. Weight regain-induced decrease in postprandial IS correlated with increases in adiponectin, fT3, TSH, GL of the diet and a decrease in ghrelin levels (r-values between -0.40 and 0.83, p<0.05 whereas increases in early and total insulin secretion were associated with a decrease in leptin/adiponectin-ratio (r = -0.52 and r = -0.46, p<0.05 and a decrease in fT4 (r = -0.38, p<0.05 for total insulin secretion only. After controlling for GL associations between RF-induced decrease in postprandial IS and increases in fT3 and TSH levels were no longer significant.Weight cycling induced changes in IS and insulin secretion were associated with changes in all measured hormones, except for catecholamine excretion. While leptin, adiponectin and ghrelin seem to be the major

  12. Effects of immobilisation and caloric restriction on antioxidant parameters and T-cell apoptosis in healthy young men

    Science.gov (United States)

    Ellinger, S.; Arendt, B. M.; Boese, A.; Juschus, M.; Schaefer, S.; Stoffel-Wagner, B.; Goerlich, R.

    Background: Astronauts are exposed to oxidative stress due to radiation and microgravity, which might impair immune functions. Effects of hypocaloric nutrition as often observed in astronauts on oxidative stress and immune functions are not clear. We investigated, if microgravity, simulated by 6 Head-down tilt (HDT) and caloric restriction (-25%, fat reduced) with adequate supply of micronutrients affect DNA-damage in peripheral leukocytes, antioxidant parameters in plasma, and T-cell apoptosis. Material & Methods: 10 healthy male non-smokers were subjected to 4 different interventions (normocaloric diet or caloric restriction (CR) in upright position (UP) or HDT) for 14 days each (cross-over). DNA-damage in peripheral leukocytes (Comet Assay), trolox equivalent antioxidant capacity (TEAC) and uric acid in plasma were measured before, after 5, 10, and 13 days of intervention, and after 2 days recovery. T-cell apoptosis (Annexin V binding test) was assessed before and after intervention. Results: Preliminary results show that only endogenous, but not ex vivo H2O2-induced DNA strand breaks were reduced by CR compared to normocaloric diet. In upright position, endogenous DNA strand breaks decreased continuously during CR, reaching significance after recovery. During HDT, caloric restriction seems to counteract a temporary increase in DNA strand breaks observed in subjects receiving normocaloric diet. TEAC was reduced during HDT compared to UP in subjects under caloric restriction. An increase in plasma uric acid related to intervention occurred only after 5 days HDT in CR vs. normocaloric diet. T-cell apoptosis was not affected by any kind of intervention. Conclusion: Neither HDT nor CR with sufficient supply of micronutrients seem to induce oxidative stress or T-cell apoptosis in healthy young men. In contrast, CR might prevent endogenous DNA-damage in peripheral leukocytes. As DNA-damage is a risk factor for carcinogenesis, protective effects of energy reduction are

  13. Red ginseng relieves the effects of alcohol consumption and hangover symptoms in healthy men: a randomized crossover study.

    Science.gov (United States)

    Lee, Mi-Hyang; Kwak, Jung Hyun; Jeon, Gayoung; Lee, Jong-Won; Seo, Jang-Ho; Lee, Hoon-Sang; Lee, Jong Ho

    2014-03-01

    Heavy drinking causes hangover symptoms, because the action of alcohol dehydrogenase forms acetaldehyde, which is metabolized by acetaldehyde dehydrogenase into acetate. Red ginseng shows positive effects on alcohol metabolism in animal studies. We investigated the effects of red ginseng on relieving alcohol and hangover symptoms in 25 healthy men in a randomized crossover study. At each visit (0, 1, and 2 weeks), the subjects drank 100 mL whiskey (40% alcohol) and either 100 mL water or 100 mL of a 0.321 mg mL(-1) red ginseng anti-hangover drink (RGD). We took blood samples periodically until 240 min after alcohol consumption, and we investigated the blood profiles, alcohol levels, and acetaldehyde levels. We also measured anthropometric parameters, expiratory air-alcohol levels, and hangover symptoms. The plasma alcohol concentrations within the RGD group were significantly lower than those within the placebo group after 30 min (p = 0.002), 45 min (p = 0.016), and 60 min (p = 0.009); the areas under the response curves revealed a positive effect of RGD (p = 0.051). Furthermore, the expiratory alcohol concentration was significantly lower after 30 min (p = 0.005) and 60 min (p = 0.065), and the areas under the response curves (p = 0.058) likewise revealed a positive effect of RGD. The plasma acetaldehyde level was significantly elevated at 120 min (p = 0.020), but the areas under the response curves showed a similar trend (p = 0.054). While the plasma acetaldehyde concentration slightly increased, the RGD showed positive effects on hangover symptoms. Considering the reduction of plasma alcohol levels, expiratory concentrations, and hangover severity, we conclude that red ginseng relieves the symptoms of alcohol hangover. PMID:24458173

  14. Alterations in functional connectivity of resting state networks during experimental endotoxemia - An exploratory study in healthy men.

    Science.gov (United States)

    Labrenz, Franziska; Wrede, Karsten; Forsting, Michael; Engler, Harald; Schedlowski, Manfred; Elsenbruch, Sigrid; Benson, Sven

    2016-05-01

    Systemic inflammation impairs mood and cognitive functions, and seems to be involved in the pathophysiology of psychiatric disorders. Functional magnetic resonance imaging (fMRI) studies revealed altered task-related blood-oxygen-level-dependent (BOLD) responses during experimental endotoxemia, but little is known about effects of systemic inflammation on resting-state activity of the brain. Thus, we conducted a randomized, placebo-controlled study in healthy men receiving an intravenous injection of either low-dose (0.4ng/kg) lipopolysaccharide (LPS) (N=20) or placebo (N=25). Resting state activity was measured at baseline and 3.5h post-injection. Based on a two (condition)×two (group) design, we used multi-subject independent component analysis (ICA) to decompose and estimate functional connectivity within resting-state networks (RSNs). Seed-based analyses were applied to investigate the effect of LPS on the functional coupling for a priori-defined regions-of-interest (ROIs). ICA analyses identified 13 out of 35 components displaying common RSNs. Seed based analysis revealed greater functional connectivity between the left thalamus and the cerebellum after LPS compared to placebo administration, while the functional coupling between seeds within the amygdala, insula, and cingulate cortex and various brain regions including parieto-frontal networks was significantly reduced. Within the LPS group, endotoxin-induced increases in Interleukin (IL)-6 were significantly associated with resting-state connectivity between the left thalamus and left precuneus as well as the right posterior cingulate cortex. In summary, this exploratory study provides first evidence that systemic inflammation affects the coupling and regulation of multiple networks within the human brain at rest. PMID:26597151

  15. Cortisol responses to mental stress and the progression of coronary artery calcification in healthy men and women.

    Directory of Open Access Journals (Sweden)

    Mark Hamer

    Full Text Available BACKGROUND: Psychosocial stress is a risk factor for coronary heart disease (CHD. The mechanisms are incompletely understood, although dysfunction of the hypothalamic pituitary adrenal (HPA axis might be involved. We examined the association between cortisol responses to laboratory-induced mental stress and the progression of coronary artery calcification (CAC. METHODS AND RESULTS: Participants were 466 healthy men and women (mean age = 62.7±5.6 yrs, without history or objective signs of CHD, drawn from the Whitehall II epidemiological cohort. At the baseline assessment salivary cortisol was measured in response to mental stressors, consisting of a 5-min Stroop task and a 5-min mirror tracing task. CAC was measured at baseline and at 3 years follow up using electron beam computed tomography. CAC progression was defined as an increase >10 Agatston units between baseline and follow up. 38.2% of the sample demonstrated CAC progression over the 3 years follow up. There was considerable variation in the cortisol stress response, with approximately 40% of the sample responding to the stress tasks with an increase in cortisol of at least 1 mmol/l. There was an association between cortisol stress reactivity (per SD and CAC progression (odds ratio = 1.27, 95% CI, 1.02-1.60 after adjustments for age, sex, pre-stress cortisol, employment grade, smoking, resting systolic BP, fibrinogen, body mass index, and use of statins. There was no association between systolic blood pressure reactivity and CAC progression (odds ratio per SD increase = 1.03, 95% CI, 0.85-1.24. Other independent predictors of CAC progression included age, male sex, smoking, resting systolic blood pressure, and fibrinogen. CONCLUSION: Results demonstrate an association between heightened cortisol reactivity to stress and CAC progression. These data support the notion that cortisol reactivity, an index of HPA function, is one of the possible mechanisms through which

  16. A single bout of exercise with a flexible pole induces significant cardiac autonomic responses in healthy men

    Directory of Open Access Journals (Sweden)

    Cristiane M. Ogata

    2014-09-01

    Full Text Available OBJECTIVES: Flexible poles can provide rapid eccentric and concentric muscle contractions. Muscle vibration is associated with a "tonic vibration reflex” that is stimulated by a sequence of rapid muscle stretching, activation of the muscle spindles and stimulation of a response that is similar to the myotatic reflex. Literature studies analyzing the acute cardiovascular responses to different exercises performed with this instrument are lacking. We investigated the acute effects of exercise with flexible poles on the heart period in healthy men. METHOD: The study was performed on ten young adult males between 18 and 25 years old. We evaluated the heart rate variability in the time and frequency domains. The subjects remained at rest for 10 min. After the rest period, the volunteers performed the exercises with the flexible poles. Immediately after the exercise protocol, the volunteers remained seated at rest for 30 min and their heart rate variability was analyzed. RESULTS: The pNN50 was reduced at 5-10 and 15-20 min after exercise compared to 25-30 min after exercise (p = 0.0019, the SDNN was increased at 25-30 min after exercise compared to at rest and 0-10 min after exercise (p = 0.0073 and the RMSSD was increased at 25-30 min after exercise compared to 5-15 min after exercise (p = 0.0043. The LF in absolute units was increased at 25-30 min after exercise compared to 5-20 min after exercise (p = 0.0184. CONCLUSION: A single bout of exercise with a flexible pole reduced the heart rate variability and parasympathetic recovery was observed approximately 30 min after exercise.

  17. Effect of 12 Weeks of Periodized Resistance Training Upon Total Plasma Adiponectin Concentration in Healthy Young Men.

    Science.gov (United States)

    Davis, Greggory R; Stephens, Jacqueline M; Nelson, Arnold G

    2015-11-01

    The effects of resistance training on adiponectin have thus far yielded equivocal results. However, the effect of periodized resistance training on plasma adiponectin in offspring of type 2 diabetic and nondiabetic (ND) parents (first-degree family history) has yet to be determined. Untrained healthy young men with and without a first-degree family history of type 2 diabetes were assigned to an exercise intervention group (E) or an active control group (C). The E group performed a 12-week periodized resistance training program, whereas the C group did not participate in any structured exercise program. Fasting plasma samples were obtained pre- and posttraining. Total plasma adiponectin changed significantly in the E group (33.7 ± 14.7%, p = 0.025) but not in the C group (10.8 ± 19.2%). Offspring of type 2 diabetic parents subjects had significantly greater improvements in plasma adiponectin (69.3 ± 34.8%) compared with ND subjects (-3.2 ± 29.9%, p = 0.046). Regular aerobic exercise was significantly correlated with average plasma adiponectin (r = 0.32), whereas first-degree family history of type 2 diabetes (r = -0.58) and decreases in body fat percentage (r = -0.77) were inversely correlated with average plasma adiponectin. Periodized high-intensity resistance training seems to increase plasma adiponectin, particularly in individuals with a first-degree family history of type 2 diabetes or those who experience a significant loss of fat mass. The direct correlation between regular aerobic exercise and adiponectin further suggests that a combination of aerobic and resistance training yields greater improvements in plasma adiponectin compared with resistance training alone. PMID:26274372

  18. Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 1, a pharmacokinetic/pharmacodynamic comparison with paroxetine in healthy men

    OpenAIRE

    Wilson, Sue; Højer, Astrid-Maria; Buchberg, Jeppe; Areberg, Johan; Nutt, David J.

    2015-01-01

    We compared the effect of vortioxetine, paroxetine and placebo after three days of dosing on sleep architecture. This was a randomised, double-blind, four-way crossover, placebo-controlled, multiple-dose study in 24 healthy young men. Subjects received 20mg vortioxetine, 40mg vortioxetine, 20mg paroxetine or placebo for three consecutive days in four different periods with at least three weeks between them. Polysomnography and blood sampling for pharmacokinetic analysis were performed on the ...

  19. ROLE OF PHYSICAL EXERCISE, FITNESS AND AEROBIC TRAINING IN TYPE 1 DIABETIC AND HEALTHY MEN IN RELATION TO THE LIPID PROFILE, LIPID PEROXIDATION AND THE METABOLIC SYNDROME

    Directory of Open Access Journals (Sweden)

    David E. Laaksonen

    2003-06-01

    Full Text Available Dyslipidemia and possibly lipid peroxidation play important roles in the development of macro- and microvascular disease in type 1 diabetes mellitus. Little is known, however, of the role of aerobic exercise in dyslipidemia and resting and exercise-induced lipid peroxidation in type 1 diabetes. Despite the well-known effect of leisure-time physical activity (LTPA on components of the metabolic syndrome, little is known of the association of LTPA and cardiorespiratory fitness (maximal oxygen consumption, VO2max with development of the metabolic syndrome itself. A randomized controlled trial assessing the effect of a 12-16 week aerobic exercise program on VO2max and the lipid profile was carried out in otherwise healthy young men with type 1 diabetes. The effect of acute physical exercise on oxidative stress and antioxidant defenses and the relation to VO2max in men with type 1 diabetes was also evaluated. To test four recently proposed definitions by the World Health Organization (WHO and National Cholesterol Education Program (NCEP of the metabolic syndrome, the sensitivity and specificity of the definitions for prevalent and incident diabetes were assessed in a population-based cohort of middle-aged men. We also studied the associations of LTPA and cardiorespiratory fitness with prevalent and incident cases of the metabolic syndrome. A 12-16 week endurance exercise program produced antiatherogenic changes in lipid, lipoprotein and apolipoprotein levels in 20 type 1 diabetic men who for the most part were already physically active at baseline. The most favorable training-induced changes in the high-density lipoprotein cholesterol (HDL/low-density lipoprotein cholesterol (LDL and apolipoprotein A-I/apolipoprotein B ratios were in patients with low baseline HDL/LDL levels, likely the group with the most benefit to be gained by such changes. Plasma thiobarbituric acid reactive substances (TBARS, a measure of lipid peroxidation, was higher in nine

  20. The serotonin-1A receptor distribution in healthy men and women measured by PET and [carbonyl-{sup 11}C]WAY-100635

    Energy Technology Data Exchange (ETDEWEB)

    Stein, Patrycja; Savli, Markus; Fink, Martin; Spindelegger, Christoph; Moser, Ulrike; Kasper, Siegfried; Lanzenberger, Rupert [Medical University of Vienna, Department of Psychiatry and Psychotherapy, Vienna (Austria); Wadsak, Wolfgang; Dudczak, Robert; Kletter, Kurt [Medical University of Vienna, Department of Nuclear Medicine, Vienna (Austria); Mitterhauser, Markus; Mien, Leonhard-Key [Medical University of Vienna, Department of Nuclear Medicine, Vienna (Austria); University of Vienna, Department of Pharmaceutical Technology, Vienna (Austria)

    2008-12-15

    The higher prevalence rates of depression and anxiety disorders in women compared to men have been associated with sexual dimorphisms in the serotonergic system. The present positron emission tomography (PET) study investigated the influence of sex on the major inhibitory serotonergic receptor subtype, the serotonin-1A (5-HT{sub 1A}) receptor. Sixteen healthy women and 16 healthy men were measured using PET and the highly specific radioligand [carbonyl-{sup 11}C]WAY-100635. Effects of age or gonadal hormones were excluded by restricting the inclusion criteria to young adults and by controlling for menstrual cycle phase. The 5-HT{sub 1A} receptor BP{sub ND} was quantified using (1) the 'gold standard' manual delineation approach with ten regions of interest (ROIs) and (2) a newly developed delineation method using a PET template normalized to the Montreal Neurologic Institute space with 45 ROIs based on automated anatomical labeling. The 5-HT{sub 1A} receptor BP{sub ND} was found equally distributed in men and women applying both the manual delineation method and the automated delineation approach. Women had lower mean BP{sub ND} values in every region investigated, with a borderline significant sex difference in the hypothalamus (p=0.012, uncorrected). There was a high intersubject variability of the 5-HT{sub 1A} receptor BP{sub ND} within both sexes compared to the small mean differences between men and women. To conclude, when measured in the follicular phase, women do not differ from men in the 5-HT{sub 1A} receptor binding. To explain the higher prevalence of affective disorders in women, further studies are needed to evaluate the relationship between hormonal status and the 5-HT{sub 1A} receptor expression. (orig.)

  1. The serotonin-1A receptor distribution in healthy men and women measured by PET and [carbonyl-11C]WAY-100635

    International Nuclear Information System (INIS)

    The higher prevalence rates of depression and anxiety disorders in women compared to men have been associated with sexual dimorphisms in the serotonergic system. The present positron emission tomography (PET) study investigated the influence of sex on the major inhibitory serotonergic receptor subtype, the serotonin-1A (5-HT1A) receptor. Sixteen healthy women and 16 healthy men were measured using PET and the highly specific radioligand [carbonyl-11C]WAY-100635. Effects of age or gonadal hormones were excluded by restricting the inclusion criteria to young adults and by controlling for menstrual cycle phase. The 5-HT1A receptor BPND was quantified using (1) the 'gold standard' manual delineation approach with ten regions of interest (ROIs) and (2) a newly developed delineation method using a PET template normalized to the Montreal Neurologic Institute space with 45 ROIs based on automated anatomical labeling. The 5-HT1A receptor BPND was found equally distributed in men and women applying both the manual delineation method and the automated delineation approach. Women had lower mean BPND values in every region investigated, with a borderline significant sex difference in the hypothalamus (p=0.012, uncorrected). There was a high intersubject variability of the 5-HT1A receptor BPND within both sexes compared to the small mean differences between men and women. To conclude, when measured in the follicular phase, women do not differ from men in the 5-HT1A receptor binding. To explain the higher prevalence of affective disorders in women, further studies are needed to evaluate the relationship between hormonal status and the 5-HT1A receptor expression. (orig.)

  2. The effect of sex on immune cells in healthy aging: Elderly women have more robust natural killer lymphocytes than do elderly men.

    Science.gov (United States)

    Al-Attar, Ahmad; Presnell, Steven R; Peterson, Charlotte A; Thomas, D Travis; Lutz, Charles T

    2016-06-01

    Immune gender differences have been reported, but are little studied in elderly humans. We compared monocyte and lymphocyte subsets, along with soluble immune mediators in healthy men and women over the age of 70. We also measured natural killer (NK) lymphocyte cytotoxic granule exocytosis, chemokine synthesis, and cytokine synthesis in response to a variety of stimuli. Elderly women had significantly more circulating B cells than men, whereas men had more CD4 central memory T cells and higher monocyte levels. Plasma adiponectin levels were higher in women, plasma retinol-binding protein 4 levels were higher in men, but there were no significant gender differences in C-reactive protein, IL-15, or sphingosine-1-phosphate. Women had a higher ratio of immature CD56(bright) NK cells to mature CD56(dim) NK cells, indicating a gender difference in NK cell maturation in the elderly. Comparing sexes, female mature NK cells had more vigorous cytotoxic granule responses to K562 leukemia cells and IFN-γ responses to NKp46 crosslinking. Moreover, female NK cells were more likely to produce MIP-1β in response to a variety of stimuli. These data show that gender influences NK cell activity in elderly humans. PMID:27059724

  3. Effect of Lepidium meyenii Walp. on Semen Parameters and Serum Hormone Levels in Healthy Adult Men: A Double-Blind, Randomized, Placebo-Controlled Pilot Study

    Science.gov (United States)

    Melnikovova, Ingrid; Fait, Tomas; Kolarova, Michaela; Fernandez, Eloy C.; Milella, Luigi

    2015-01-01

    Background/Aims. Products of Lepidium meyenii Walp. (maca) are touted worldwide as an alimentary supplement to enhance fertility and restore hormonal balance. Enhancing properties of maca on semen parameters in animals were previously reported by various authors, but we present to the best of our knowledge the first double-blind, randomized, placebo-controlled pilot trial in men. The aim of this study was to evaluate the effects of maca on semen parameters and serum hormone levels in healthy adult men. Methods. A group of 20 volunteers aged 20–40 years was supplied by milled hypocotyl of maca or placebo (1.75 g/day) for 12 weeks. Negative controls of semen were compared to the samples after 6 and 12 weeks of maca administration; negative blood controls were compared to the samples after 12 weeks of treatment. Results. Sperm concentration and motility showed rising trends compared to placebo even though levels of hormones did not change significantly after 12 weeks of trial. Conclusion. Our results indicate that maca possesses fertility enhancing properties in men. As long as men prefer to use alimentary supplement to enhance fertility rather than prescribed medication or any medical intervention, it is worth continuing to assess its possible benefits. PMID:26421049

  4. Parabens in urine, serum and seminal plasma from healthy Danish men determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS)

    DEFF Research Database (Denmark)

    Frederiksen, Hanne; Jørgensen, Niels; Andersson, Anna-Maria

    2011-01-01

    Parabens are used as anti-microbial preservatives in a range of consumer products, especially in cosmetics. In vitro and animal studies have shown weak estrogenic and other endocrine disrupting effects of parabens, including reduced testosterone levels in exposed male rats. The knowledge of paraben...... exposure, distribution and excretion in humans is limited. In this study we determined the concentration of five parabens; methyl-, ethyl-, n-propyl-, n-butyl- and benzylparaben in urine, serum and seminal plasma samples from 60 healthy Danish men. To conduct the study a sensitive and specific method using...... LC-MS/MS for simultaneous determination of the five parabens was developed for all three different matrices. Highest concentrations of the parabens were found in urine, wherein methyl-, ethyl-, n-propyl- and n-butyl parabens were measurable in 98%, 80%, 98% and 83% of the men, respectively. Benzyl...

  5. "Moderate Stress Enhances Immediate and Delayed Retrieval of Educationally Relevant Material in Healthy Young Men": Correction to Hupbach and Fieman (2012).

    Science.gov (United States)

    2016-06-01

    Reports an error in "Moderate stress enhances immediate and delayed retrieval of educationally relevant material in healthy young men" by Almut Hupbach and Rachel Fieman (Behavioral Neuroscience, 2012[Dec], Vol 126[6], 819-825). In the article there are computational errors in the last sentence of the Memory Performance section. "(M = .30, SD = .11 for CPS, and M = .13, SD = 17 for the warm water control)." should read instead: "(M = .03, SD = .11 for CPS, and M = .13, SD = .17 for the warm water control)." (The following abstract of the original article appeared in record 2012-27908-001.) Retrieval practice is a powerful memory enhancer. However, in educational settings, test taking is often experienced as a stressful event. While it is known that stress can impair retrieval processes, little is known about the delayed consequences of testing memory for educationally relevant material under stressful conditions, which is the focus of the present study. Participants (38 women, 37 men) memorized a scientific text passage on Day 1. On Day 2, they were either exposed to a stressor (cold pressor test; CPS) or a warm water control, and immediately afterward, they were asked to recall the text passage (i.e., retrieval under stress vs. control). Salivary cortisol was measured as an index of the stress response before, and 20 min after the CPS versus control treatment. The delayed effects of testing under stress were assessed with a final recall test on Day 3. In comparison to the control condition, CPS caused significant increases in salivary cortisol, and, surprisingly resulted in enhanced memory in men. Importantly, this enhancement was not only observed in the test that immediately followed the stressor, but also in the delayed test. In women, CPS caused only marginal increases in cortisol concentrations, and retrieval remained unaffected. Our study suggests that moderate stress can improve memory performance for educationally relevant material in a long-lasting manner

  6. Effects of alfuzosin and tamsulosin on sperm parameters in healthy men: results of a short-term, randomized, double-blind, placebo-controlled, crossover study.

    Science.gov (United States)

    Hellstrom, Wayne J G; Sikka, Suresh C

    2009-01-01

    Ejaculation disorders are associated with tamsulosin treatment for lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH). To assess whether tamsulosin has any effect on semen, sperm parameters were evaluated in healthy men receiving tamsulosin, alfuzosin, and placebo. Forty-eight healthy men received 5 days of tamsulosin 0.8 mg once daily (QD), alfuzosin 10 mg QD, and placebo in a randomized, double-blind, 3-way crossover study with a 10-14-day washout period between treatments. The changes (x +/- SE) from baseline in semen sperm concentration, semen sperm count, semen viscosity, semen fructose, sperm motility, and sperm morphology on day 5 of treatment were assessed. The change from baseline in semen sperm concentration was 3.1 +/- 8.3 million/mL with tamsulosin, 15.0 +/- 6.5 million/mL with alfuzosin, and 24.4 +/- 6.5 million/mL with placebo. The total sperm count in semen decreased from baseline with tamsulosin (-54.6 +/- 24.0 million) but not with placebo (81.5 +/- 18.8 million) or alfuzosin (46.2 +/- 19.0 million). The percentage of men with normal semen viscosity was lower with tamsulosin (65%) than with placebo (98%) or alfuzosin (92%). The change from baseline in semen fructose was comparable for all treatments. The percentage of motile sperm decreased 13.8% from baseline to day 5 of treatment with tamsulosin compared with decreases of 2.3% with placebo and 0.4% with alfuzosin. The percentage of abnormal sperm increased marginally with tamsulosin (0.6%) but not with placebo (-2.8%) or alfuzosin (-3.9%). The most common adverse events were dizziness (alfuzosin 11%, tamsulosin 14%, placebo 0%) and orthostatic hypotension (alfuzosin 25%, tamsulosin 11%, placebo 5%). The results suggest that tamsulosin has a negative effect on sperm in healthy men. Studies on the effects of alpha(1)-adrenergic blockers on sperm in men with BPH are warranted. PMID:19201696

  7. Health-Related Physical Fitness in Healthy Untrained Men: Effects on VO2max, Jump Performance and Flexibility of Soccer and Moderate-Intensity Continuous Running

    OpenAIRE

    Zoran Milanović; Saša Pantelić; Goran Sporiš; Magni Mohr; Peter Krustrup

    2015-01-01

    The purpose of this study was to determine the effects of recreational soccer (SOC) compared to moderate-intensity continuous running (RUN) on all health-related physical fitness components in healthy untrained men. Sixty-nine participants were recruited and randomly assigned to one of three groups, of which sixty-four completed the study: a soccer training group (SOC; n = 20, 34±4 (means±SD) years, 78.1±8.3 kg, 179±4 cm); a running group (RUN; n = 21, 32±4 years, 78.0±5.5 kg, 179±7 cm); or a...

  8. Reference intervals and variation for urinary epinephrine, norepinephrine and cortisol in healthy men and women in Denmark

    DEFF Research Database (Denmark)

    Hansen, Åse Marie; Garde, A H; Christensen, J M;

    2001-01-01

    Reference intervals for urinary epinephrine, norepinephrine and cortisol in 120 healthy individuals performing their routine work were established according to the International Union of Pure and Applied Chemistry (IUPAC) and the International Federation of Clinical Chemistry and Laboratory Medic...

  9. Healthy Eating for Women

    Science.gov (United States)

    ... For Parents For Men For Women For Seniors Healthy Eating for Women Published April 11, 2014 Print Email ... Food Health Nutrition Wellness Dietary Guidelines and MyPlate Healthy Eating Healthy Aging For Women Latest Content 1 2 ...

  10. RESPONSE OF SELENIUM STATUS INDICATORS TO SUPPLEMENTATION OF HEALTHY NORTH AMERICAN MEN WITH HIGH-SELENIUM YEAST

    Science.gov (United States)

    In a prior study, we observed decreased serum 3,3’,5-triiodothyronine (t3), increased serum thyrotropin and increased body weight in 5 men fed 297 'g/d of selenium (Se) in foods naturally high in Se while confined in a metabolic research unit. In an attempt to replicate and confirm those observation...

  11. Differences in homeostatic model assessment (HOMA) values and insulin levels after vitamin D supplementation in healthy men: a double-blind randomized controlled trial.

    Science.gov (United States)

    Tepper, S; Shahar, D R; Geva, D; Ish-Shalom, S

    2016-06-01

    Vitamin D is thought to play a role in glucose metabolism. The aim of the present study was to determine the effect of vitamin D supplementation on markers of insulin sensitivity and inflammation in men without diabetes with vitamin D deficiency/insufficiency. In this 1-year double-blind randomized controlled trial, 130 men aged 20-65 years (mean age 47.52 ± 11.84 years) with serum 25-hydroxyvitamin D levels treatment (100 000 IU vitamin D bimonthly) or placebo. Anthropometric measurements, demographic questionnaires, and blood indices (fasting glucose, insulin, high-sensitivity C-reactive protein, lipids) were collected and repeated after 6 and 12 months. The compliance rate was 98.5%. Multivariate models, adjusted for baseline levels, age, body mass index, sun exposure, physical activity and LDL, showed significant differences in insulin and homeostatic model assessment of insulin resistance (HOMA-IR) values between groups. Levels of insulin and HOMA-IR values remained steady during the study period in the treatment group but increased by 16% in the control group (p = 0.038 and p = 0.048, respectively). Vitamin D supplementation administered for 12 months in healthy men maintained insulin levels and HOMA-IR values relative to the increase in the control group. Further studies are needed to establish the long-term effect of vitamin D supplementation on the risk of diabetes. PMID:26890031

  12. PSYCHOPHYSIOLOGIC AND IMMUNOLOGIC CHARACTERISTICS IN PATIENTS WITH BRONCHIAL ASTHMA AND HEALTHY MEN WITH DIFFERENT FUNCTIONAL ASYMMETRY OF BRAIN HEMISPHERES

    Directory of Open Access Journals (Sweden)

    T. Ya. Abramova

    2014-07-01

    Full Text Available Abstract. Possible interactions between psychophysiological and immunological parameters are documented in healthy persons and bronchial asthma patients, as based on our own data and other sources. A role of functional asymmetry of brain is regarded as a basic phenomenon determining main features of psychical activity, as well as functions of autonomous nervous system and immunological activity.

  13. Acute Exposure to Stress Improves Performance in Trace Eyeblink Conditioning and Spatial Learning Tasks in Healthy Men

    Science.gov (United States)

    Duncko, Roman; Cornwell, Brian; Cui, Lihong; Merikangas, Kathleen R.; Grillon, Christian

    2007-01-01

    The present study investigated the effects of acute stress exposure on learning performance in humans using analogs of two paradigms frequently used in animals. Healthy male participants were exposed to the cold pressor test (CPT) procedure, i.e., insertion of the dominant hand into ice water for 60 sec. Following the CPT or the control procedure,…

  14. Elevated resting heart rate is an independent risk factor for cardiovascular disease in healthy men and women.

    LENUS (Irish Health Repository)

    Cooney, Marie Therese

    2010-04-01

    Elevated resting heart rate (RHR) is known to be associated with reduced survival but inconsistencies remain, including lack of significance in most studies of healthy women, lack of independence from systolic blood pressure (SBP) in some, and the suggestion that RHR is merely functioning as a marker of physical inactivity or other comorbidities. We aimed to clarify these inconsistencies.

  15. Acute effect of pegvisomant on cardiovascular risk markers in healthy men: implications for the pathogenesis of atherosclerosis in GH deficiency

    NARCIS (Netherlands)

    A.F. Muller (Alex); S.W.J. Lamberts (Steven); L.J. Hofland (Leo); A-J. van der Lely (Aart-Jan); F.W.G. Leebeek (Frank); J.A.M.J.L. Janssen (Joop)

    2001-01-01

    textabstractCardiovascular risk is increased in GH deficiency (GHD). GHD adults are frequently abdominally obese and display features of the metabolic syndrome. Otherwise healthy abdominally obese subjects have low GH levels and show features of the metabolic syndrome as well. We i

  16. The effect of gum chewing on blood GLP-1 concentration in fasted, healthy, non-obese men

    OpenAIRE

    Xu, Jianping; Xiao, Xinhua; Li, Yuxiu; Zheng, Jia; Li, Wenhui; Qian ZHANG; Wang, Zhixin

    2015-01-01

    We evaluated the effect of chewing on blood GLP-1 concentration by having volunteers to chew sugarless gum. Our intention was to explore the neural mechanisms regulating the secretion of glucagon-like peptide-1(GLP-1). After fasting for 12 h, 12 healthy male, non-obese volunteers (18 

  17. Test-retest reliability of the net joint power transferred by the lower limbs during walking in healthy men

    OpenAIRE

    Daniel Jandačka; Jaroslav Uchytil; Zdeněk Svoboda; Milan Elfmark; Miroslav Janura

    2013-01-01

    OBJECTIVE: To determine the reliability of the measurement of net joint power during repeated gait measurements within one day and between two different measurement days. METHODS: Thirty able-bodied men who underwent repeated gait measurements within a day and between days participated in this research. An acceptable trial was one in which the participant complied with the range of walking speed 1.45 m/s ± 5%. Three-dimensional angles, angular velocities, net moments of force and net ...

  18. Decomposition of wheat bran and ispaghula husk in the stomach and the small intestine of healthy men

    DEFF Research Database (Denmark)

    Andersen, J R; Bukhave, K; Højgaard, L;

    1988-01-01

    for monosaccharides, either free or fiber-bound, by gas-liquid chromatography. Both types of fiber were hydrolyzed in the stomach, but not in the small bowel. Of ispaghula husk, 1-6% was hydrolyzed, as was 5-8% of wheat bran. Intestinal absorption of free arabinose was 85-93%, but excretion of arabinose in the urine......Decomposition of dietary fibers in the stomach and small bowel was studied in 13 healthy male volunteers. Liquid control meals were compared with test meals, which in addition contained a source of fiber (wheat bran or ispaghula husk) in random order. Aspirations were collected from the stomach...... was not greater than after control meals. For further evaluation of gastric hydrolysis six additional healthy male volunteers were studied by serial aspirations from the antral part of the stomach. Hydrolysis was instantaneous for both fibers, and was significantly more pronounced for wheat bran than...

  19. Acute exposure to stress improves performance in trace eyeblink conditioning and spatial learning tasks in healthy men

    OpenAIRE

    Duncko, Roman; Cornwell, Brian; Cui, Lihong; Merikangas, Kathleen R.; Grillon, Christian

    2007-01-01

    The present study investigated the effects of acute stress exposure on learning performance in humans using analogs of two paradigms frequently used in animals. Healthy male participants were exposed to the cold pressor test (CPT) procedure, i.e., insertion of the dominant hand into ice water for 60 sec. Following the CPT or the control procedure, participants completed a trace eyeblink conditioning task followed by a virtual navigation Morris water task (VNMWT). Hypothalamic-pituitary-adreno...

  20. Marginal Vitamin B-6 Deficiency Decreases Plasma (n-3) and (n-6) PUFA Concentrations in Healthy Men and Women123

    OpenAIRE

    Zhao, Mei; Lamers, Yvonne; Ralat, Maria A.; Coats, Bonnie S.; Chi, Yueh-Yun; Keith E. Muller; Bain, James R.; Shankar, Meena N; Newgard, Christopher B.; Stacpoole, Peter W.; Gregory, Jesse F.

    2012-01-01

    Previous animal studies showed that severe vitamin B-6 deficiency altered fatty acid profiles of tissue lipids, often with an increase of linoleic acid and a decrease of arachidonic acid. However, little is known about the extent to which vitamin B-6 deficiency affects human fatty acid profiles. The aim of this study was to determine the effects of marginal vitamin B-6 deficiency on fatty acid profiles in plasma, erythrocytes, and peripheral blood mononuclear cells (PBMC) of healthy adults fe...

  1. A single Mediterranean meal does not impair postprandial flow-mediated dilatation in healthy men with subclinical metabolic dysregulations.

    Science.gov (United States)

    Lacroix, Sébastien; Des Rosiers, Christine; Gayda, Mathieu; Nozza, Anna; Thorin, Éric; Tardif, Jean-Claude; Nigam, Anil

    2016-08-01

    Cardiovascular risk factors are known to exacerbate high-saturated fatty acid meal (HSFAM)-induced endothelial dysfunction, but the influence of subclinical metabolic dysregulations and the acute impact of a single mixed Mediterranean-type meal (MMM) remains unknown. Thus, this study has the objective to evaluate the metabolic and vascular effect of such meals in healthy subjects with or without subclinical fasting metabolic dysregulations. Twenty-eight healthy males without overt cardiovascular risk factors randomly ingested 1 of 2 isocaloric meals on separate days. Plasma metabolic markers, fatty acid (FA) profile, and endothelial function (flow-mediated dilatation; FMD) were assessed at baseline and 2 and 4 h after meal ingestion. Unsupervised hierarchical clustering identified 2 subgroups of participants (n = 11 and 17) differing by their baseline metabolic profiles. The MMM did not significantly alter postprandial endothelial function in all subjects, irrespective of baseline metabolic parameters. In contrast, the HSFAM induced postprandial endothelial dysfunction (Δ%FMDabsolute = -5.28 ± 2.54, p < 0.01 vs. MMM) in a subgroup of individuals with significantly greater body mass index, fasting insulinemia, and lipid parameters (n = 11). Finally, the postprandial plasma FA profiles were differentially enriched by the HSFAM and MMM, notably with saturated FAs and omega-3 polyunsaturated FAs, respectively. Collectively, our results highlight the detrimental impact of a single HSFAM on endothelial function in healthy individuals displaying subclinical fasting metabolic dysregulations. Such individuals could benefit from MMM, demonstrated herein to be without any acute detriment to endothelial function. PMID:27454855

  2. Changes in insulin sensitivity precede changes in body composition during 14 days of step reduction combined with overfeeding in healthy young men

    DEFF Research Database (Denmark)

    Knudsen, Sine Haugaard; Hansen, Louise Seier; Pedersen, Maria;

    2012-01-01

    in inflammatory markers. At day 30, body weight and whole body adiposity were still elevated compared with day 0 (P <0.05), whereas the insulin sensitivity as well as the insulin response to the OGTT did not differ from baseline. The glucose response to the OGTT was only affected at day 30, with a......A lifestyle characterized by inactivity and a high-calorie diet is a known risk factor for impaired insulin sensitivity and development of Type 2 diabetes mellitus. To investigate possible links, nine young healthy men (24 ± 3 yr; body mass index of 21.6 ± 2.5 kg/m(2)) completed 14 days of step...... reduction (10,000 to 1,500 steps/day) and overfeeding (+50% kcal). Body composition (dual X-ray absorptiometry, MRI), aerobic fitness (maximal O(2) consumption), systemic inflammation and insulin sensitivity [oral glucose tolerance test (OGTT), hyperinsulinemic euglycemic clamp] were assessed before (day 0...

  3. Whole-body cryostimulation--potential beneficial treatment for improving antioxidant capacity in healthy men--significance of the number of sessions.

    Directory of Open Access Journals (Sweden)

    Anna Lubkowska

    Full Text Available It is claimed that WBC (whole-body cryotherapy enhances the resistance of the human body, also thanks to the beneficial effect on the antioxidant system. Accordingly, this research aimed to evaluate the effect of a series of whole-body cryostimulations on the level of non-enzymatic antioxidants and the activity of antioxidant enzymes in healthy men. The study was carried out on 30 young and healthy men aged 27.8±6.1 years with average body mass index and peak oxygen consumption (46.34±6.15 ml kg(-1 •min(-1. The participants were daily exposed for 3 minutes to cryogenic temperatures (-130°C. Blood samples were obtained in the morning before cryostimulation, again 30 min after exposure and the following day in the morning, during the 1(st, 10(th and 20(th session. Analysis concerned changes in plasma concentrations of total protein, albumin, glucose, uric acid and ceruloplasmin, and the most important components of the antioxidant system in red blood cells: superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, reduced and oxidized glutathione. To assess the oxidative stress level the 8-isoprostane concentration in plasma was measured. The obtained results indicate that cryogenic temperatures in repeated daily treatments result in changes in the peroxidant and antioxidant status. These changes seem to depend on the number of cryostimulations. After 20 daily treatments there was an increase in SOD, SOD:CAT ratio, a decrease in the concentration of reduced and oxidized glutathione and in the activity of GPx. It could be possible that differences in the activity of GSSG-R after 20 treatments depended on the body mass index of participants.

  4. Impact of short-term high-fat feeding on glucose and insulin metabolism in young healthy men

    DEFF Research Database (Denmark)

    Brøns, Charlotte; Jensen, Christine B.; Storgaard, Heidi;

    2009-01-01

    a control diet on hepatic and peripheral insulin action by a hyperinsulinaemic euglycaemic clamp, muscle mitochondrial function by (31)P magnetic resonance spectroscopy, and gene expression by qrt-PCR and microarray in 26 young men. Hepatic glucose production and fasting glucose levels increased...... significantly in response to overfeeding. However, peripheral insulin action, muscle mitochondrial function, and general and specific oxidative phosphorylation gene expression were unaffected by high-fat feeding. Insulin secretion increased appropriately to compensate for hepatic, and not for peripheral......, insulin resistance. High-fat feeding increased fasting levels of plasma adiponectin, leptin and gastric inhibitory peptide (GIP). High-fat overfeeding increases fasting glucose levels due to increased hepatic glucose production. The increased insulin secretion may compensate for hepatic insulin resistance...

  5. Effect of individual dietary fatty acids on postprandial activation of blood coagulation factor VII and fibrinolysis in healthy young men

    DEFF Research Database (Denmark)

    Tholstrup, T.; Miller, G.J.; Bysted, Anette;

    2003-01-01

    Background: Hypertriglyceridemia may represent a procoagulant state involving disturbances to the hemostatic system. Plasminogen activator inhibitor type 1 (PAI-1) is increased in the presence of hypertriglyceridemia. Free fatty acids (FFAs) in plasma may promote factor VII (FVII) activation....... Objective: We tested the hypothesis that FVII activation would be less after consumption of saturated fatty acids than after other fatty acids. Design: The effects of 6 matching dietary test fats, rich in stearic (S), palmitic (P), palmitic + myristic (M), oleic (O), trans 18:1 (T), and linoleic (L) acid......, respectively, on the postprandial lipid and hemostatic profile (after 2, 4, 6, and 8 h) were investigated in 16 young men. High-fat meals (1 g fat/kg body wt; 43% from the test fatty acid) were served in the morning on 6 separate days. Results: All fats increased FVII activation. The S fat resulted in a lower...

  6. Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study

    OpenAIRE

    Yang Long In; Lim Hyo Hee; Kim Oh Yoen; Chae Jey Sook; Lee Jong Ho

    2011-01-01

    Abstract Background We investigated the relationship between fatty acid desaturase (FADS) gene polymorphisms and insulin resistance (IR) in association with serum phospholipid polyunsaturated fatty acid (FA) composition in healthy Korean men. Methods Healthy men (n = 576, 30 ~ 79 years old) were genotyped for rs174537 near FADS1 (FEN1-10154G>T), FADS2 (rs174575C>G, rs2727270C>T), and FADS3 (rs1000778C>T) SNPs. Dietary intake, serum phospholipid FA composition and HOMA-IR were measured. Result...

  7. Effects of aerobic exercise training on heart rate variability during wakefulness and sleep and cardiorespiratory responses of young and middle-aged healthy men

    Directory of Open Access Journals (Sweden)

    A.M. Catai

    2002-06-01

    Full Text Available The purpose of the present study was to evaluate the effects of aerobic physical training (APT on heart rate variability (HRV and cardiorespiratory responses at peak condition and ventilatory anaerobic threshold. Ten young (Y: median = 21 years and seven middle-aged (MA = 53 years healthy sedentary men were studied. Dynamic exercise tests were performed on a cycloergometer using a continuous ramp protocol (12 to 20 W/min until exhaustion. A dynamic 24-h electrocardiogram was analyzed by time (TD (standard deviation of mean R-R intervals and frequency domain (FD methods. The power spectral components were expressed as absolute (a and normalized units (nu at low (LF and high (HF frequencies and as the LF/HF ratio. Control (C condition: HRV in TD (Y: 108, MA: 96 ms; P<0.05 and FD - LFa, HFa - was significantly higher in young (1030; 2589 ms²/Hz than in middle-aged men (357; 342 ms²/Hz only during sleep (P<0.05; post-training effects: resting bradycardia (P<0.05 in the awake condition in both groups; VO2 increased for both groups at anaerobic threshold (P<0.05, and at peak condition only in young men; HRV in TD and FD (a and nu was not significantly changed by training in either groups. The vagal predominance during sleep is reduced with aging. The resting bradycardia induced by short-term APT in both age groups suggests that this adaptation is much more related to intrinsic alterations in sinus node than in efferent vagal-sympathetic modulation. Furthermore, the greater alterations in VO2 than in HRV may be related to short-term APT.

  8. Acute effects of a single warm-water bath on serum adiponectin and leptin levels in healthy men: A pilot study

    Science.gov (United States)

    Shimodozono, Megumi; Matsumoto, Shuji; Ninomiya, Koji; Miyata, Ryuji; Ogata, Atsuko; Etoh, Seiji; Watanabe, Satoshi; Kawahira, Kazumi

    2012-09-01

    To preliminarily assess the acute effects of a single warm -water bath (WWB) on serum adipokine activity, we measured serum adiponectin, leptin and other metabolic profiles before, immediately after and 30 minutes after WWB in seven healthy male volunteers (mean age, 39.7 ± 6.0 years; mean body mass index, 21.6 ± 1.8 kg/m2). The subjects were immersed in tap water at 41°C for 10 minutes. Two weeks later, the same subjects underwent a single WWB with a bath additive that included inorganic salts and carbon dioxide (WWB with ISCO2) by the same protocol as for the first WWB. Leptin levels significantly increased immediately after WWB with tap water and ISCO2 (both P Adiponectin levels showed a slight, but not significant, increase both immediately after and 30 minutes after WWB with tap water or ISCO2. Some parameters, such as serum total cholesterol, red blood cell count, hemoglobin and hematocrit significantly increased immediately after WWB with tap water or ISCO2 (all P adiponectin profiles in healthy men.

  9. Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women.

    Science.gov (United States)

    Zhao, Mei; Lamers, Yvonne; Ralat, Maria A; Coats, Bonnie S; Chi, Yueh-Yun; Muller, Keith E; Bain, James R; Shankar, Meena N; Newgard, Christopher B; Stacpoole, Peter W; Gregory, Jesse F

    2012-10-01

    Previous animal studies showed that severe vitamin B-6 deficiency altered fatty acid profiles of tissue lipids, often with an increase of linoleic acid and a decrease of arachidonic acid. However, little is known about the extent to which vitamin B-6 deficiency affects human fatty acid profiles. The aim of this study was to determine the effects of marginal vitamin B-6 deficiency on fatty acid profiles in plasma, erythrocytes, and peripheral blood mononuclear cells (PBMC) of healthy adults fed a 28-d, low-vitamin B-6 diet. Healthy participants (n = 23) received a 2-d, controlled, vitamin B-6-adequate diet followed by a 28-d, vitamin B-6-restricted diet to induce a marginal deficiency. Plasma HDL and LDL cholesterol concentrations, FFA concentrations, and erythrocyte and PBMC membrane fatty acid compositions did not significantly change from baseline after the 28-d restriction. Plasma total arachidonic acid, EPA, and DHA concentrations decreased from (mean ± SD) 548 ± 96 to 490 ± 94 μmol/L, 37 ± 13 to 32 ± 13 μmol/L, and 121 ± 28 to 109 ± 28 μmol/L [positive false discovery rate (pFDR) adjusted P pFDR adjusted P < 0.05). These data indicate that short-term vitamin B-6 restriction decreases plasma (n-3) and (n-6) PUFA concentrations and tends to increase the plasma (n-6):(n-3) PUFA ratio. Such changes in blood lipids may be associated with the elevated risk of cardiovascular disease in vitamin B-6 insufficiency. PMID:22955512

  10. Differential Kinetics in Alteration and Recovery of Cognitive Processes from a Chronic Sleep Restriction in Young Healthy Men

    Science.gov (United States)

    Rabat, Arnaud; Gomez-Merino, Danielle; Roca-Paixao, Laura; Bougard, Clément; Van Beers, Pascal; Dispersyn, Garance; Guillard, Mathias; Bourrilhon, Cyprien; Drogou, Catherine; Arnal, Pierrick J.; Sauvet, Fabien; Leger, Damien; Chennaoui, Mounir

    2016-01-01

    Chronic sleep restriction (CSR) induces neurobehavioral deficits in young and healthy people with a morning failure of sustained attention process. Testing both the kinetic of failure and recovery of different cognitive processes (i.e., attention, executive) under CSR and their potential links with subject’s capacities (stay awake, baseline performance, age) and with some biological markers of stress and anabolism would be useful in order to understand the role of sleep debt on human behavior. Twelve healthy subjects spent 14 days in laboratory with 2 baseline days (B1 and B2, 8 h TIB) followed by 7 days of sleep restriction (SR1-SR7, 4 h TIB), 3 sleep recovery days (R1–R3, 8 h TIB) and two more ones 8 days later (R12–R13). Subjective sleepiness (KSS), maintenance of wakefulness latencies (MWT) were evaluated four times a day (10:00, 12:00 a.m. and 2:00, 4:00 p.m.) and cognitive tests were realized at morning (8:30 a.m.) and evening (6:30 p.m.) sessions during B2, SR1, SR4, SR7, R2, R3 and R13. Saliva (B2, SR7, R2, R13) and blood (B1, SR6, R1, R12) samples were collected in the morning. Cognitive processes were differently impaired and recovered with a more rapid kinetic for sustained attention process. Besides, a significant time of day effect was only evidenced for sustained attention failures that seemed to be related to subject’s age and their morning capacity to stay awake. Executive processes were equally disturbed/recovered during the day and this failure/recovery process seemed to be mainly related to baseline subject’s performance and to their capacity to stay awake. Morning concentrations of testosterone, cortisol and α-amylase were significantly decreased at SR6-SR7, but were either and respectively early (R1), tardily (after R2) and not at all (R13) recovered. All these results suggest a differential deleterious and restorative effect of CSR on cognition through biological changes of the stress pathway and subject’s capacity (Clinical

  11. Effects of enzyme-treated asparagus extract on heat shock protein 70, stress indices, and sleep in healthy adult men.

    Science.gov (United States)

    Ito, Tomohiro; Goto, Kazunori; Takanari, Jun; Miura, Takehito; Wakame, Koji; Nishioka, Hiroshi; Tanaka, Aiko; Nishihira, Jun

    2014-01-01

    Enzyme-treated asparagus extract (ETAS) has been developed as a novel anti-stress functional food ingredient that is produced from asparagus. Two human intervention trials with ETAS were conducted in healthy adult male volunteers. Study 1 was a randomized, double-blind, placebo-controlled study to assess the effects of ETAS on expression of heat shock protein 70 (HSP70) mRNA in blood and the autonomic nervous system (ANS). The ETAS group showed a tendency to enhance HSP70 mRNA expression level compared to the placebo group. Several ANS condition parameters were significantly improved in the ETAS group when compared to the placebo group. In Study 2, a randomized, double-blind, placebo-controlled, crossover trial investigated the influence on stress-related hormones and sleep. Serum and salivary cortisol levels were significantly elevated compared to baseline during the placebo period, but remained unchanged during the ETAS period. The salivary chromogranin A level was significantly decreased in the ETAS-treated subjects compared to their baseline levels. The actual sleep time was not significantly different between ETAS and placebo. However, when the subjects were divided into two categories based on sleep efficiency or the average of night sleeping time, ETAS intake was effective to modulate the sleep state among those with low sleep efficiency or excess sleep time. PMID:25297618

  12. Cigarette smoking increases levels of retinol-binding protein-4 in healthy men with normal glucose tolerance

    Institute of Scientific and Technical Information of China (English)

    GAO Shan; WANG Yong-hui; LI Ming

    2012-01-01

    Background Smoking is related with insulin resistance and type 2 diabetes mellitus.Retinol-binding protein-4 is a new adipocytokine associated with insulin resistance.We investigated the serum levels of a series of adipocytokines including retinol-binding protein-4 in smokers and non-smokers to explore the possible roles of adipocytokines on smoking induced insulin resistance.Methods A total of 136 healthy male subjects (92 smokers and 44 non-smokers) with normal glucose tolerance were enrolled in the study.Adipocytokines including retinol-binding protein-4,visfatin,leptin,resistin,adiponectin were measured for the comparison between the two groups.Serum lipid profile,glucose,true insulin and proinsulin levels were measured as well in both groups.Food intake spectrum was also investigated.Results Both groups had similar profile of food consumption; visfatin,leptin,resistin and adiponectin,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol,alanine aminotransferase,aspartate aminotransferase,as well as blood pressure and body mass index,were similar in both groups.Triglycerides,retinol-binding protein-4 and homeostatic model assessment index for insulin resistance were higher in smoker group ((2.58±2.53) vs.(1.60±0.94)mmol/L,(26.05±8.50) vs.(21.83±8.40) μg/ml,and 2.25±2.08 vs.1.58±1.15,respectively).Conclusion Smoking may have effect on insulin sensitivity,which is correlated with retinol-binding protein-4.

  13. OF PHYSIOLOGICAL REACTIONS AND PHYSIOLOGICAL STRAIN IN HEALTHY MEN UNDER HEAT STRESS IN DRY AND STEAM HEAT SAUNAS

    Directory of Open Access Journals (Sweden)

    W. Pilch

    2014-07-01

    Full Text Available The aim of the paper was to follow up major physiological reactions, provoked by heat stress during dry and wet sauna baths. A physical strain index and subjective estimation of heat comfort of subjects who had not taken sauna baths before was also evaluated. Ten healthy males aged 25-28 underwent a dry sauna bath and then after a one-month break they underwent a steam sauna bath. Each time, they entered the sauna chamber 3 times for 15 minutes with five-minute breaks. During breaks they cooled their bodies with a cold shower and then rested in a sitting position. Before and after the baths, body mass and blood pressure were measured. Rectal temperature and heart rate were monitored during the baths. The physiological strain index (PSI and cumulative heat strain index (CHSI were calculated. Subjects assessed heat comfort by Bedford’s scale. Greater body mass losses were observed after the dry sauna bath compared to the wet sauna (-0.72 vs. -0.36 kg respectively. However, larger increases in rectal temperature and heart rate were observed during the wet sauna bath (38.8% and 21.2% respectively. Both types of sauna baths caused elevation of systolic blood pressure, but changes were greater after the dry one. Diastolic pressure was reduced similarly. Subjective feelings of heat comfort as well as PSI (4.83 ± 0.29 vs. 5.7 ± 0.28 and CHSI (76.3 ± 18.4 vs. 144.6 ± 21.7 were greater during the wet sauna bath. It can be concluded that due to high humidity and reduction of thermoregulation mechanisms, the wet sauna is more stressful for the organism than the dry sauna, where the temperature is higher with low humidity. Both observed indexes (PSI and CHSI could be appropriate for objective assessment of heat strain during passive heating of the organism.

  14. The effect of gum chewing on blood GLP-1 concentration in fasted, healthy, non-obese men.

    Science.gov (United States)

    Xu, Jianping; Xiao, Xinhua; Li, Yuxiu; Zheng, Jia; Li, Wenhui; Zhang, Qian; Wang, Zhixin

    2015-09-01

    We evaluated the effect of chewing on blood GLP-1 concentration by having volunteers to chew sugarless gum. Our intention was to explore the neural mechanisms regulating the secretion of glucagon-like peptide-1(GLP-1). After fasting for 12 h, 12 healthy male, non-obese volunteers (18 chew sugarless gum at a frequency of 80 times every 2 min for a total of 30 min. Blood samples were collected before the start of chewing and 5, 10, 15, 20, 25, and 30 min after the start of chewing. Satiety and hunger were evaluated on a scale from 0 to 100 at each time point. Compared with the control group, the test group's satiety was increased at 15, 25, and 30 min (p = 0.043, p = 0.014 and p = 0.018, respectively) after they began chewing sugarless gum 80 times every 2 min. The blood GLP-1 level of the test group at 30 min was 49.6 ± 20.3 pmol/l, significantly higher than that of the control group (38.9 ± 20.9 pmol/l; p = 0.031). There was no significant difference in the test group's GLP-1 concentration at each time point. In the control group, compared to baseline, the GLP-1 concentrations at 15, 25, and 30 min were significantly decreased (p = 0.042, p = 0.0214 and p = 0.012, respectively). No significant differences in the blood concentration of glucose, insulin and GIP or hunger were observed between groups. Our study suggests that fasting sugarless gum chewing can increase satiety and reduce the decrease in GLP-1 concentration. PMID:25758865

  15. Coronary artery plaque burden and calcium scores in healthy men adhering to long-term wine drinking or alcohol abstinence

    Energy Technology Data Exchange (ETDEWEB)

    Luz, P.L. da; Coimbra, S.; Favarato, D.; Albuquerque, C. [Divisão de Cardiologia Clínica, Instituto do Coração (Incor), Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil); Mochiduky, R.I.; Rochitte, C.E. [Divisão de Radiologia, Instituto do Coração (Incor), Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil); Hojaij, E. [Serviço de Psicologia, Instituto do Coração (Incor), Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil); Gonsalves, C.R.L. [Serviço Nutricional, Instituto do Coração (Incor), Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil); Laurindo, F.R. [Laboratório de Biologia Vascular, Instituto do Coração (Incor), Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil)

    2014-07-04

    Observational studies suggest there are clinical benefits to moderate red wine (RW) consumption. However, the effects on coronary vasculature and overall lifestyle are unclear. We investigated whether a lifestyle of regular long-term RW consumption is associated with changes in coronary plaque burden, calcium score, carotid intima/media thickness, endothelial function, and metabolic variables, compared with alcohol abstinence. Healthy volunteers were evaluated by coronary computed tomography angiography (CTA) as well as carotid and brachial artery ultrasound. Nutritional status, psychological status, and metabolic variables were assessed. The study included 101 drinkers [aged 58.9±7.3 years (means±SD)], from wine brotherhoods, and 104 abstainers, from Anglican, Evangelical and Catholic churches both in the city of São Paulo, Brazil. No significant differences in demographics were noted. Lesion prevalence per patient assessed by coronary CTA and classified as absent (0), 1-25, 26-49, and ≥50% stenosis was similar between groups. When analyzed by individual arteries, i.e., left anterior descending, circumflex, and right coronary, prevalence was also not different. On the other hand, calcium scores were higher among drinkers than abstainers (144.4±362.2 vs 122.0±370.3; P<0.01). However, drinkers reported less history of diabetes and exercised more. RW drinkers consumed 2127.9±387.7 kcal/day while abstainers consumed 1836.0±305.0 (P<0.0001). HDL cholesterol was significantly higher among drinkers compared to abstainers (46.9±10.9 vs 39.5±9.0 mg/dL; P<0.001), while fasting plasma glucose was lower (97.6±18.2 vs 118.4±29.6 mg/dL; P<0.02). Liver enzymes were normal in both groups. In conclusion, long-term wine drinkers displayed a similar plaque burden but greater calcium score than abstainers, despite a more atherogenic diet, and the mechanisms for the increased calcium scores in the former remain speculative.

  16. Coronary artery plaque burden and calcium scores in healthy men adhering to long-term wine drinking or alcohol abstinence

    Directory of Open Access Journals (Sweden)

    P.L. da Luz

    2014-08-01

    Full Text Available Observational studies suggest there are clinical benefits to moderate red wine (RW consumption. However, the effects on coronary vasculature and overall lifestyle are unclear. We investigated whether a lifestyle of regular long-term RW consumption is associated with changes in coronary plaque burden, calcium score, carotid intima/media thickness, endothelial function, and metabolic variables, compared with alcohol abstinence. Healthy volunteers were evaluated by coronary computed tomography angiography (CTA as well as carotid and brachial artery ultrasound. Nutritional status, psychological status, and metabolic variables were assessed. The study included 101 drinkers [aged 58.9±7.3 years (means±SD], from wine brotherhoods, and 104 abstainers, from Anglican, Evangelical and Catholic churches both in the city of São Paulo, Brazil. No significant differences in demographics were noted. Lesion prevalence per patient assessed by coronary CTA and classified as absent (0, 1-25, 26-49, and ≥50% stenosis was similar between groups. When analyzed by individual arteries, i.e., left anterior descending, circumflex, and right coronary, prevalence was also not different. On the other hand, calcium scores were higher among drinkers than abstainers (144.4±362.2 vs 122.0±370.3; P<0.01. However, drinkers reported less history of diabetes and exercised more. RW drinkers consumed 2127.9±387.7 kcal/day while abstainers consumed 1836.0±305.0 (P<0.0001. HDL cholesterol was significantly higher among drinkers compared to abstainers (46.9±10.9 vs 39.5±9.0 mg/dL; P<0.001, while fasting plasma glucose was lower (97.6±18.2 vs 118.4±29.6 mg/dL; P<0.02. Liver enzymes were normal in both groups. In conclusion, long-term wine drinkers displayed a similar plaque burden but greater calcium score than abstainers, despite a more atherogenic diet, and the mechanisms for the increased calcium scores in the former remain speculative.

  17. Effects of different doses of testosterone on gonadotropins, 25-hydroxyvitamin D3, and blood lipids in healthy men

    Directory of Open Access Journals (Sweden)

    Gårevik N

    2014-12-01

    Full Text Available Nina Gårevik, Anders Rane, Linda Björkhem-Bergman, Lena Ekström Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden Aims: To study the effect and time profile of different doses of testosterone enanthate on the blood lipid profile and gonadotropins. Experimental design: Twenty-five healthy male volunteers aged 27–43 years were given 500 mg, 250 mg, and 125 mg of testosterone enanthate as single intramuscular doses of Testoviron® Depot. Luteinizing hormone (LH, follicle-stimulating hormone (FSH, blood lipid profile (total cholesterol, plasma [p-] low-density lipoprotein, p-high-density lipoprotein [HDL], p-apolipoprotein A1 [ApoA1], p-apolipoprotein B, p-triglycerides, p-lipoprotein(a, serum [s-] testosterone, and 25-hydroxyvitamin D3 were analyzed prior to, and 4 and 14 days after dosing. Testosterone and epitestosterone in urine (testosterone/epitestosterone ratio were analyzed prior to each dose after a washout period of 6–8 weeks. Results and discussion: All doses investigated suppressed the LH and FSH concentrations in serum. LH remained suppressed 6 weeks after the 500 mg dose. These results indicate that testosterone has a more profound endocrine effect on the hypothalamic–pituitary–gonadal axis than was previously thought. There was no alteration in 25-hydroxyvitamin D3 levels after testosterone administration compared to baseline levels. The 250 and 500 mg doses induced decreased concentrations of ApoA1 and HDL, whereas the lowest dose (125 mg did not have any effect on the lipid profile. Conclusion: The single doses of testosterone produced a dose-dependent increase in serum testosterone concentrations together with suppression of s-LH and s-FSH. Alterations in ApoA1 and HDL were observed after the two highest single doses. It is possible that long-time abuse of anabolic androgenic steroids will lead to alteration in vitamin D status

  18. Coronary artery plaque burden and calcium scores in healthy men adhering to long-term wine drinking or alcohol abstinence

    International Nuclear Information System (INIS)

    Observational studies suggest there are clinical benefits to moderate red wine (RW) consumption. However, the effects on coronary vasculature and overall lifestyle are unclear. We investigated whether a lifestyle of regular long-term RW consumption is associated with changes in coronary plaque burden, calcium score, carotid intima/media thickness, endothelial function, and metabolic variables, compared with alcohol abstinence. Healthy volunteers were evaluated by coronary computed tomography angiography (CTA) as well as carotid and brachial artery ultrasound. Nutritional status, psychological status, and metabolic variables were assessed. The study included 101 drinkers [aged 58.9±7.3 years (means±SD)], from wine brotherhoods, and 104 abstainers, from Anglican, Evangelical and Catholic churches both in the city of São Paulo, Brazil. No significant differences in demographics were noted. Lesion prevalence per patient assessed by coronary CTA and classified as absent (0), 1-25, 26-49, and ≥50% stenosis was similar between groups. When analyzed by individual arteries, i.e., left anterior descending, circumflex, and right coronary, prevalence was also not different. On the other hand, calcium scores were higher among drinkers than abstainers (144.4±362.2 vs 122.0±370.3; P<0.01). However, drinkers reported less history of diabetes and exercised more. RW drinkers consumed 2127.9±387.7 kcal/day while abstainers consumed 1836.0±305.0 (P<0.0001). HDL cholesterol was significantly higher among drinkers compared to abstainers (46.9±10.9 vs 39.5±9.0 mg/dL; P<0.001), while fasting plasma glucose was lower (97.6±18.2 vs 118.4±29.6 mg/dL; P<0.02). Liver enzymes were normal in both groups. In conclusion, long-term wine drinkers displayed a similar plaque burden but greater calcium score than abstainers, despite a more atherogenic diet, and the mechanisms for the increased calcium scores in the former remain speculative

  19. Fatty acid desaturase (FADS gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study

    Directory of Open Access Journals (Sweden)

    Yang Long In

    2011-04-01

    Full Text Available Abstract Background We investigated the relationship between fatty acid desaturase (FADS gene polymorphisms and insulin resistance (IR in association with serum phospholipid polyunsaturated fatty acid (FA composition in healthy Korean men. Methods Healthy men (n = 576, 30 ~ 79 years old were genotyped for rs174537 near FADS1 (FEN1-10154G>T, FADS2 (rs174575C>G, rs2727270C>T, and FADS3 (rs1000778C>T SNPs. Dietary intake, serum phospholipid FA composition and HOMA-IR were measured. Results Fasting insulin and HOMA-IR were significantly higher in the rs174575G allele carriers than the CC homozygotes, but lower in the rs2727270T allele carriers than the CC homozygotes. The proportion of linoleic acid (18:2ω-6, LA was higher in the minor allele carriers of FEN1-10154G>T, rs174575C>G and rs2727270C>T than the major homozygotes, respectively. On the other hand, the proportions of dihomo-γ-linolenic acid (20:3ω-6, DGLA and arachidonic acid (20:4ω-6, AA in serum phospholipids were significantly lower in the minor allele carriers of FEN1-10154 G>T carriers and rs2727270C>T than the major homozygotes respectively. AA was also significantly lower in the rs1000778T allele carriers than the CC homozygotes. HOMA-IR positively correlated with LA and DGLA and negatively with AA/DGLA in total subjects. Interestingly, rs174575G allele carriers showed remarkably higher HOMA-IR than the CC homozygotes when subjects had higher proportions of DLGA (≥1.412% in total serum phospholipid FA composition (P for interaction = 0.009 or of AA (≥4.573% (P for interaction = 0.047. Conclusion HOMA-IR is associated with FADS gene cluster as well as with FA composition in serum phospholipids. Additionally, HOMA-IR may be modulated by the interaction between rs174575C>G and the proportion of DGLA or AA in serum phospholipids.

  20. Effects of a palatinose-based liquid diet (Inslow) on glycemic control and the second-meal effect in healthy men.

    Science.gov (United States)

    Arai, Hidekazu; Mizuno, Akira; Sakuma, Masae; Fukaya, Makiko; Matsuo, Kaoru; Muto, Kazusa; Sasaki, Hajime; Matsuura, Motoi; Okumura, Hisami; Yamamoto, Hironori; Taketani, Yutaka; Doi, Toshio; Takeda, Eiji

    2007-01-01

    Postprandial hyperglycemia induces prolonged hyperinsulinemia, which is a risk factor for type 2 diabetes mellitus. Foods with a low glycemic index blunt the rapid rise in postprandial plasma glucose and insulin levels. We herein investigated the effects of a novel, palatinose-based liquid diet (Inslow, Meiji Dairy Products, Tokyo, Japan) on postprandial plasma glucose and insulin levels and on the rate of substrate oxidation in 7 healthy men. Furthermore, to examine the effects of Inslow on the second-meal effect, we quantified our subjects' postprandial plasma glucose, insulin, and free fatty acid levels for up to 7 hours after they ingested a breakfast containing Inslow or control formula, followed by a standard lunch 5 hours later. Our results showed that peak plasma glucose and insulin levels 30 minutes after Inslow loading were lower than after control formula loading. Postprandial fat oxidation rates in the Inslow group were higher than in the control formula group (P consumption of Inslow at breakfast appears to improve patient glycemic control by reducing their postprandial plasma glucose and insulin levels after lunch (second-meal effect). PMID:17161233

  1. Effect of Low-Intensity Aerobic Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Proteins in Healthy Men

    Directory of Open Access Journals (Sweden)

    Yuichiro Nishida

    2010-01-01

    Full Text Available Increased concentrations of circulating insulin-like growth factor-I (IGF-I or IGF-I relative to IGF-binding proteins (IGFBPs are associated with increased risk of developing several forms of cancer. Conversely, exercise is linked with reduced risk. This study aims to investigate the effect of a low-intensity exercise program on circulating levels of IGF-I, IGFBP-1, and IGFBP-3, in previously sedentary males. Fourteen healthy men participated in cycle ergometer training at lactate threshold intensity for 60 min/day, 5 days/week for 6 weeks. After aerobic training, insulin sensitivity improved by 20%, while fasting insulin levels decreased by 13%. Simultaneously, low-intensity aerobic training decreased the circulating levels of IGF-I by 9%, while IGFBP-1 levels increased by 16%. An interesting finding was that higher pretraining level of IGF-I was associated with greater decline in IGF-I with training. Insulin-sensitizing low-intensity aerobic exercise is thus considered to be an effective method for downregulating IGF-I and upregulating IGFBP-1 levels.

  2. The effect of 8-week aerobic interval training and a detraining period on left ventricular structure and function in non-athlete healthy men

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    Abbasali Gaeini

    2012-02-01

    Full Text Available Background: Exercise plays an important role to improve cardiovascular performance. The purpose of this study was to determine the effect 8wk of aerobic cyclic training and a detraining period on left ventricular structure and function in non-athlete healthy men.Materials and Method: In this research, ten male non-athlete students were volunteered and participated in a 8- week running program (3days/week, at 70% of Maximum Heart Rate and 4 weeks detraining afterwards. In each session, cyclic running was done in 5 nine-minute stages and there was a four-minute inactive rest among them.Results: Using echocardiography, there was a significant difference in interventricular septal thickness, percent of rapid shortening and percent of ejection fraction after 8 weeks training compared to before training. It was found no significant difference end-diastolic and end-systolic dimensions, posterior wall thickness, left atrium diameter, aortic root thickness, heart rate, systolic and diastolic blood pressures. There was a significant difference in end-systolic dimension, intervntricular septal thickness, left atrium diameter, percent of rapid shortening and ejection fraction following 4-week detraining after training compared to 8-week.Conclusion: Eight-week aerobic cyclic training and a detraining period can effect on left ventricle structure and function

  3. A diet rich in conjugated linoleic acid and butter increases lipid peroxidation but does not affect atherosclerotic, inflammatory, or diabetic risk markers in healthy young men

    DEFF Research Database (Denmark)

    Raff, Marianne; Tholstrup, Tine; Basu, Samar; Nonboe, Pernille; Sørensen, Martin Tang; Straarup, Ellen Marie

    2008-01-01

    fat intake. Our objective was to investigate the effect of CLA as part of a diet rich in butter as a source of milk fat on risk markers of atherosclerosis, inflammation, diabetes type 11, and lipid peroxidation. A total of 38 healthy young men were given a diet with 115g/d of CLA-rich fat (5.5 g/d CLA...... oil, a mixture of 39.4% cis9, trans11 and 38.5% trans10, cis12) or of control fat with a low content of CLA in a 5-wk double-blind, randomized, parallel intervention study. We collected blood and urine before and after the intervention. The fatty acid composition of plasma triacylglycerol, cholesterol......Intake of conjugated linoleic acid (CLA) has been demonstrated to beneficially affect risk markers of atherosclerosis and diabetes in rats. CLA is naturally found in milk fat, especially from cows fed a diet high in oleic acid, and increased CLA intake can occur concomitantly with increased milk...

  4. Psychometrics of healthy young men living in Beijing%北京市健康青年男性心理检测抽样调查分析

    Institute of Scientific and Technical Information of China (English)

    钱文红; 杜兵; 唐建; 吴柏林

    2011-01-01

    目的 了解北京市18个区县健康青年男性心理健康程度,为开展北京市青少年心理健康管理奠定基础.方法 对自愿报名参加某专项体检并达标的北京市健康男性青年进行心理检测,检测方法 主要有计算机检测、纸笔智力检测、结构式心理访谈等,依照受检者的各项检测结果 来判定心理检测是否合格.结果 自2006年10月至2009年10月对北京市18个区县的18~22岁28 386名健康青年男性进行心理检测,总体合格率为94.68%(26 876/28 386).四年度心理检测不合格率分别为2006年为2.53%、2007年为3.28%、2008年为7.56%、2009年为7.52%.结论 我市该年龄段青年心理状况总体情况较好,高于全国平均水平,这可能与我市心理教育总体水平高、升学率高、市民经济状况较好、父母学历水平较高、社会精神文明建设活动多姿多彩等有重要关系;该计算机心理检测软件具有一定的稳定性.%Objective To understand the mental health status of healthy young men from 18 districts or counties in Beijing,so as to provide evidence for mental health management.MethodsVolunteers who had participated physical check-ups and got normal results underwent psychological examinations,including computer tests,paper pencil intelligence tests,and structured psychological interviews.Results From 2006 to 2009,a total of 28 386 healthy young men from 18 districts or counties of Beijing completed psychological examinations.The unqualification rate was 2.53%,3.28%,7.56% and 7.52% in year 2006,2007,2008 and 2009,respectively.Conclusion The overall psychological condition of young men living in Beijing may be comparatively better,which might be related to the higher level of psychological education,increased school-entrance rate,better economic condition,higher educational level of parents and improved social and cultural activities.The computer software for psychological test could be stable to some certain extent.

  5. Health-Related Physical Fitness in Healthy Untrained Men: Effects on VO2max, Jump Performance and Flexibility of Soccer and Moderate-Intensity Continuous Running.

    Directory of Open Access Journals (Sweden)

    Zoran Milanović

    Full Text Available The purpose of this study was to determine the effects of recreational soccer (SOC compared to moderate-intensity continuous running (RUN on all health-related physical fitness components in healthy untrained men. Sixty-nine participants were recruited and randomly assigned to one of three groups, of which sixty-four completed the study: a soccer training group (SOC; n = 20, 34±4 (means±SD years, 78.1±8.3 kg, 179±4 cm; a running group (RUN; n = 21, 32±4 years, 78.0±5.5 kg, 179±7 cm; or a passive control group (CON; n = 23, 30±3 years, 76.6±12.0 kg, 178±8 cm. The training intervention lasted 12 weeks and consisted of three 60-min sessions per week. All participants were tested for each of the following physical fitness components: maximal aerobic power, minute ventilation, maximal heart rate, squat jump (SJ, countermovement jump with arm swing (CMJ, sit-and-reach flexibility, and body composition. Over the 12 weeks, VO2max relative to body weight increased more (p<0.05 in SOC (24.2%, ES = 1.20 and RUN (21.5%, ES = 1.17 than in CON (-5.0%, ES = -0.24, partly due to large changes in body mass (-5.9, -5.7 and +2.6 kg, p<0.05 for SOC, RUN and CON, respectively. Over the 12 weeks, SJ and CMJ performance increased more (p<0.05 in SOC (14.8 and 12.1%, ES = 1.08 and 0.81 than in RUN (3.3 and 3.0%, ES = 0.23 and 0.19 and CON (0.3 and 0.2%, while flexibility also increased more (p<0.05 in SOC (94%, ES = 0.97 than in RUN and CON (0-2%. In conclusion, untrained men displayed marked improvements in maximal aerobic power after 12 weeks of soccer training and moderate-intensity running, partly due to large decreases in body mass. Additionally soccer training induced pronounced positive effects on jump performance and flexibility, making soccer an effective broad-spectrum fitness training intervention.

  6. Health-Related Physical Fitness in Healthy Untrained Men: Effects on VO2max, Jump Performance and Flexibility of Soccer and Moderate-Intensity Continuous Running.

    Science.gov (United States)

    Milanović, Zoran; Pantelić, Saša; Sporiš, Goran; Mohr, Magni; Krustrup, Peter

    2015-01-01

    The purpose of this study was to determine the effects of recreational soccer (SOC) compared to moderate-intensity continuous running (RUN) on all health-related physical fitness components in healthy untrained men. Sixty-nine participants were recruited and randomly assigned to one of three groups, of which sixty-four completed the study: a soccer training group (SOC; n = 20, 34±4 (means±SD) years, 78.1±8.3 kg, 179±4 cm); a running group (RUN; n = 21, 32±4 years, 78.0±5.5 kg, 179±7 cm); or a passive control group (CON; n = 23, 30±3 years, 76.6±12.0 kg, 178±8 cm). The training intervention lasted 12 weeks and consisted of three 60-min sessions per week. All participants were tested for each of the following physical fitness components: maximal aerobic power, minute ventilation, maximal heart rate, squat jump (SJ), countermovement jump with arm swing (CMJ), sit-and-reach flexibility, and body composition. Over the 12 weeks, VO2max relative to body weight increased more (pRUN (21.5%, ES = 1.17) than in CON (-5.0%, ES = -0.24), partly due to large changes in body mass (-5.9, -5.7 and +2.6 kg, pRUN and CON, respectively). Over the 12 weeks, SJ and CMJ performance increased more (pRUN (3.3 and 3.0%, ES = 0.23 and 0.19) and CON (0.3 and 0.2%), while flexibility also increased more (pRUN and CON (0-2%). In conclusion, untrained men displayed marked improvements in maximal aerobic power after 12 weeks of soccer training and moderate-intensity running, partly due to large decreases in body mass. Additionally soccer training induced pronounced positive effects on jump performance and flexibility, making soccer an effective broad-spectrum fitness training intervention. PMID:26305880

  7. THE EFFECTS OF LONG-TERM REGULAR EXERCISE ON ENDOTHELIAL FUNCTIONS, INFLAMMATORY AND THROMBOTIC ACTIVITY IN MIDDLE-AGED, HEALTHY MEN

    Directory of Open Access Journals (Sweden)

    Metin Ergün

    2006-06-01

    Full Text Available As studying with population carrying no classical cardiovascular risk factors seems to be an advantage in isolating effects of regular exercise on endothelial functions, inflammatory and thrombotic activity; the present study was designed to evaluate the clear effects of long-term regular exercise in middle-aged, healthy men. A total of 32 regularly exercising (three times per week, 12.8 ± 6.8 years men (Group I, mean age = 53.2 ± 6. 1 yrs and 32 sex- and age-matched sedentary subjects (Group II, mean age = 51.0 ± 7.7 yrs were involved in the study. All participants were non-smokers and with no history of hypertension and diabetes. During one day preceding tests, the subjects refrained from training and maintained their normal diet. In all subjects, body mass index (BMI, percentage of body fat (% BF and maximal oxygen uptake (VO2max were calculated. Serum uric acid, glucose, HbA1c, lipids, high-sensitive C-reactive protein (hs-CRP, fibrinogen levels, white blood cell (WBC and platelet count were measured. Resting heart rates and blood pressures were recorded and standard exercise stress test was applied using the modified Bruce protocol. Flow-mediated and nitrate-induced dilatation (FMD and NID of the brachial artery and carotid intima-media thickness (cIMT were evaluated as markers of endothelial functions and early atherosclerosis. Mean BMI, % BF, systolic and diastolic blood pressures, WBC and platelet count, HbA1c, total and LDL cholesterol, hs-CRP and fibrinogen levels were similar between the groups. Group I had significantly lower serum glucose, uric acid and triglyceride (p < 0.05, p < 0.005 and p < 0.05, respectively and higher HDL cholesterol levels (p < 0.0001 than in Group II. FMD values were significantly higher in Group I than in Group II (p < 0.005 while there were no significant differences in NID and cIMT measures between the groups. VO2max and cIMT showed a negative correlation in Group I (r = -0.463, p < 0.0001. Negative

  8. Men: Stay Healthy at 50+

    Science.gov (United States)

    ... Task Force Improving Primary Care Practice Health IT Integration Health Care/System Redesign Clinical-Community Linkages Care Coordination Capacity Building Behavioral and Mental Health Self-Management Support Resources Clinical Community Relationships ...

  9. Bradykinin type 2 receptor -9/-9 genotype is associated with triceps brachii muscle hypertrophy following strength training in young healthy men

    Directory of Open Access Journals (Sweden)

    Popadic Gacesa Jelena Z

    2012-11-01

    Full Text Available Abstract Background Bradykinin type 2 receptor (B2BRK genotype was reported to be associated with changes in the left-ventricular mass as a response to aerobic training, as well as in the regulation of the skeletal muscle performance in both athletes and non-athletes. However, there are no reports on the effect of B2BRK 9-bp polymorphism on the response of the skeletal muscle to strength training, and our aim was to determine the relationship between the B2BRK SNP and triceps brachii functional and morphological adaptation to programmed physical activity in young adults. Methods In this 6-week pretest-posttest exercise intervention study, twenty nine healthy young men (21.5 ± 2.7 y, BMI 24.2 ± 3.5 kg/m2 were put on a 6-week exercise protocol using an isoacceleration dynamometer (5 times a week, 5 daily sets with 10 maximal elbow extensions, 1 minute rest between sets. Triceps brachii muscle volumes were assessed by using magnetic resonance imaging before and after the strength training. Bradykinin type 2 receptor 9 base pair polymorphism was determined for all participants. Results Following the elbow extensors training, an average increase in the volume of both triceps brachii was 5.4 ± 3.4% (from 929.5 ± 146.8 cm3 pre-training to 977.6 ± 140.9 cm3 after training, p9 allele compared to individuals with one or two +9 alleles (−9/-9, 8.5 ± 3.8%; vs. -9/+9 and +9/+9 combined, 4.7 ± 4.5%, p B2BRK genotype (−9/-9, 50.2 ± 19.2%; vs. -9/+9 and +9/+9 combined, 46.8 ± 20.7%, p > 0.05. Conclusions We found that muscle morphological response to targeted training – hypertrophy – is related to polymorphisms of B2BRK. However, no significant influence of different B2BRK genotypes on functional muscle properties after strength training in young healthy non athletes was found. This finding could be relevant, not only in predicting individual muscle adaptation capacity to training or sarcopenia related to aging and inactivity, but also in

  10. Age-specific reference values for serum prostate-specific antigen in a community-based population of healthy Swedish men.

    Science.gov (United States)

    Löfman, O; Lindahl, T; Varenhorst, E

    1997-05-01

    To establish normal reference values for prostate-specific antigen (PSA) in a Swedish population we investigated 878 healthy men, 56-75 years of age. They were randomly selected from a population of 9171 males in this group. Cancer of the prostate was excluded by digital rectal examination. When digital rectal examination was suspicious for carcinoma of the prostate and/or serum PSA > 4 micrograms l-1, fine-needle aspiration biopsy was performed. Central values, values of variance and reference limits were defined by a non-parametric method in four age groups. A strong positive correlation between PSA values and age was found and the variance increased with age. The relationship between PSA value and age was non-linear. For the age group 56-60 the upper reference limit (95th percentile) was 4.6 micrograms l-1 (confidence interval, CI: 3.9-5.5). For the age groups 61-65, 66-70 and 71-75 the corresponding values were 4.4 (3.8-5.2), 7.6 (6.5-8.9) and 8.4 micrograms l-1 (7.2-9.8) respectively. For the age groups studied the increment over time of the PSA value was 2-8% per year depending on age, with an average increment per year over 15 years of 4.3%. Overall, 11% of our reference sample had a serum PSA level > 4 micrograms l-1. We consider our study population to be representative for a normal Swedish male population in these age groups. PMID:9238758

  11. A high-fat meal enriched with eicosapentaenoic acid reduces postprandial arterial stiffness measured by digital volume pulse analysis in healthy men.

    Science.gov (United States)

    Hall, Wendy L; Sanders, Katie A; Sanders, Thomas A B; Chowienczyk, Philip J

    2008-02-01

    Diets rich in eicosapentaenoic acid [EPA; 20:5(n-3)] are associated with decreased arterial stiffness, but postprandial effects on vascular function are unknown. We investigated whether an EPA-enriched high-fat meal could improve postprandial vascular function. Seventeen healthy men ingested 2 test meals (51 g fat), 1 wk apart, in random order: 5 g EPA plus high-oleic sunflower oil (HOS) vs. HOS only. A second high-fat meal (44 g fat), the same on both study days, was provided 4 h later. Blood pressure and arterial function were measured using digital volume pulse (DVP) to derive a stiffness index (DVP-SI) and reflection index in fasting subjects at 3 and 6 h following the test meal. Blood samples were taken following the test meal for plasma 8-isoprostane F2alpha, nitric oxide (NO) metabolites (NOx), glucose, insulin, triacylglycerol, and fatty acid analysis. The plasma EPA concentration (mean +/- SD) reached a peak of 2.10 +/- 0.99 mmol/L following the EPA meal (5 h) and did not rise above 0.27 +/- 0.16 mmol/L 1 h following the placebo meal. DeltaDVP-SI did not differ between the 2 test meals at 3 h but was greater at 6 h following EPA (6 h -0.65 +/- 0.65 m/s) compared with placebo (6 h -0.33 +/- 1.26 m/s). Plasma 8-isoprostane F2alpha concentrations increased by 48% at 6 h compared with baseline following the EPA meal and plasma NOx decreased following both meals, with no differences between the meals in the changes. Changes in other variables measured also did not differ after subjects consumed the 2 meals. In conclusion, adding EPA to a high-fat meal results in acute changes in vascular tone, independent of changes in oxidative stress. PMID:18203893

  12. Genetic variants associated with Von Willebrand factor levels in healthy men and women identified using the HumanCVD BeadChip.

    Science.gov (United States)

    Zabaneh, Delilah; Gaunt, Tom R; Kumari, Meena; Drenos, Fotios; Shah, Sonia; Berry, Diane; Power, Chris; Hypponen, Elina; Shah, Tina; Palmen, Jutta; Pallas, Jacky; Talmud, Philippa J; Casas, Juan Pablo; Sofat, Reecha; Lowe, Gordon; Rumley, Ann; Morris, Richard W; Whincup, Peter H; Rodriguez, Santiago; Ebrahim, Shah; Marmot, Michael G; Smith, George Davey; Lawlor, Debbie A; Kivimaki, Mika; Whittaker, John; Hingorani, Aroon D; Day, Ian N; Humphries, Steve E

    2011-07-01

    We have used the gene-centric Illumina HumanCVD BeadChip to identify common genetic determinants of Von Willebrand factor (vWF) levels in healthy men and women. The Whitehall II (WHII) study (n= 5592) and the British Women's Heart and Health Study (BWHHS) (n= 3445) were genotyped using the HumanCVD BeadChip. Replication was conducted in the British Regional Heart Study (n= 3897) and 1958 Birth Cohort (n= 5048). We identified 48 single nucleotide polymorphisms (SNPs) in four genes/regions associated with vWF at P < 10(-4) . These included 19 SNPs at the ABO blood group locus with the lead variant being rs657152 (P= 9.7 × 10(-233) ). The lead variant in the 24 VWF SNPs was rs1063856 (P= 2.3 × 10(-20) ). SNPs at ESR1 (rs6909023) and NRG1(rs1685103) showed modest associations with vWF, but these were not confirmed in a meta-analysis. Using variable selection, five SNPs at the locus for ABO and two for VWF were found to have independent associations with vWF levels. After adjustment for age and gender, the selected ABO SNPs explained 15% and the VWF SNPs an additional 2% of the variance in vWF levels. Individuals at opposite tails of the additive seven SNP allele score exhibited substantial differences in vWF levels. These data demonstrate that multiple common alleles with small effects make, in combination, important contributions to individual differences in vWF levels. PMID:21534939

  13. Translational neurophysiological markers for activity of the metabotropic glutamate receptor (mGluR2) modulator JNJ-40411813: Sleep EEG correlates in rodents and healthy men.

    Science.gov (United States)

    Ahnaou, A; de Boer, P; Lavreysen, H; Huysmans, H; Sinha, V; Raeymaekers, L; Van De Casteele, T; Cid, J M; Van Nueten, L; Macdonald, G J; Kemp, J A; Drinkenburg, W H I M

    2016-04-01

    Alterations in rapid eye movement sleep (REM) have been suggested as valid translational efficacy markers: activation of the metabotropic glutamate receptor 2 (mGluR2) was shown to increase REM latency and to decrease REM duration. The present paper addresses the effects on vigilance states of the mGluR2 positive allosteric modulator (PAM) JNJ-40411813 at different circadian times in rats and after afternoon dosing in humans. Due to its dual mGluR2 PAM/serotonin 2A (5-HT2A) receptor antagonism in rodents, mGlu2R specificity of effects was studied in wild-type (WT) and mGluR2 (-/-) mice. 5-HT2A receptor occupancy was determined in humans using positron emission tomography (PET). Tolerance development was examined in rats after chronic dosing. EEG oscillations and network connectivity were assessed using multi-channel EEG. In rats, JNJ-40411813 increased deep sleep time and latency of REM onset but reduced REM time when administered 2 h after 'lights on' (CT2): this was sustained after chronic dosing. At CT5 similar effects were elicited, at CT10 only deep sleep was enhanced. Withdrawal resulted in baseline values, while re-administration reinstated drug effects. Parieto-occipital cortical slow theta and gamma oscillations were correlated with low locomotion. The specificity of functional response was confirmed in WT but not mGluR2 (-/-) mice. A double-blind, placebo-controlled polysomnographic study in healthy, elderly subjects showed that 500 mg of JNJ-40411813 consistently increased deep sleep time, but had no effect on REM parameters. This deep sleep effect was not explained by 5-HT2A receptor binding, as in the PET study even 700 mg only marginally displaced the tracer. JNJ-40411813 elicited comparable functional responses in rodents and men if circadian time of dosing was taken into account. These findings underscore the translational potential of sleep mechanisms in evaluating mGluR2 therapeutics when administered at the appropriate circadian time. PMID

  14. Hemoglobin concentrations in 358 apparently healthy 80-year-old Danish men and women. Should the reference interval be adjusted for age?

    DEFF Research Database (Denmark)

    Milman, N.; Pedersen, Agnes Nadelmann; Ovesen, Lars; Schroll, Marianne

    2008-01-01

    -year-olds. Methods: Participants in this epidemiological health survey cohort were 358 subjects (171 men) 80 years of age. A dietary survey was performed in 232 subjects. Blood samples included Hb, red cell indices, serum ferritin, serum C-reactive protein, renal and hepatic function tests. Normality......-95 percentile 114-147 g/L in women (p= 20 had a lower frequency of anemia. There was no correlation between Hb and dietary or supplemental iron intake. In men, Hb was correlated to meat consumption. Conclusions: WHO decision limits for anemia should not be lowered in 80-year-old subjects. "Optimal" Hb...

  15. The effect of Ramadan intermittent fasting on lipid peroxidation in healthy young men while controlling for diet and sleep: A pilot study

    Directory of Open Access Journals (Sweden)

    Ahmed S BaHammam

    2016-01-01

    Conclusion: In this pilot study, under conditions of fixed sleep-wake schedules and caloric intake, Ramadan IF does not alter serum MDA levels in healthy subjects. Larger studies are needed to confirm these findings.

  16. Hemoglobin concentrations in 358 apparently healthy 80-year-old Danish men and women. Should the reference interval be adjusted for age?

    DEFF Research Database (Denmark)

    Milman, N.; Pedersen, A.N.; Ovesen, L.;

    2008-01-01

    -year-olds. Methods: Participants in this epidemiological health survey cohort were 358 subjects (171 men) 80 years of age. A dietary survey was performed in 232 subjects. Blood samples included Hb, red cell indices, serum ferritin, serum C-reactive protein, renal and hepatic function tests. Normality...

  17. Gonadal Status and Body Mass Index Jointly Determine Growth Hormone (GH)-Releasing Hormone/GH-Releasing Peptide Synergy in Healthy Men

    OpenAIRE

    Paulo, Remberto C.; Cosma, Mihaela; Soares-Welch, Cacia; Bailey, Joy N.; Mielke, Kristi L.; Miles, John M.; Bowers, Cyril Y.; Veldhuis, Johannes D.

    2007-01-01

    Context: Sex steroid hormones potentiate whereas increased body mass index (BMI) represses GH secretion. Whether sex steroids modify the negative effect of BMI on secretagogue-induced GH secretion in men is not known. The issue is important in designing GH-stimulation regimens that are relatively insensitive to both gonadal status and adiposity.

  18. Iron status in 358 apparently healthy 80-year-old Danish men and women: relation to food composition and dietary and supplemental iron intake

    DEFF Research Database (Denmark)

    Milman, Nils; Pedersen, Agnes Nadelmann; Ovesen, Lars;

    2004-01-01

    status in the elderly population. The objective was to evaluate iron status and the relationship with food composition and dietary and supplemental iron intake in an elderly population in Copenhagen County. Participants in this health examination survey were 358 subjects (171 men, 187 women) 80 years of...

  19. GH administration changes myosin heavy chain isoforms in skeletal muscle but does not augment muscle strength or hypertrophy, either alone or combined with resistance exercise training in healthy elderly men

    DEFF Research Database (Denmark)

    Lange, Kai Henrik Wiborg; Andersen, Jesper Løvind; Beyer, Nina;

    2002-01-01

    GH administration, either alone or combined with resistance exercise training (RT), has attracted interest as a means of increasing muscle mass and strength in the elderly. In the present study, 31 healthy, elderly men [age, 74 +/- 1 yr (mean +/- SEM)] were assigned to either RT [3 sessions/wk, 3...... baseline and after 12 wk. The final GH dose was 1.77 +/- 0.18 IU x d(-1) (approximately 7.2 +/- 0.8 microg x kg(-1) x d(-1)). GH alone had no effect on isokinetic quadriceps muscle strength, power, CSA, or fiber size. However, a substantial increase in MHC 2X isoform was observed with GH administration...... mass, increased fat-free mass, and unchanged bone mineral content with GH administration. A high incidence of side effects was reported. Our results do not support a role for GH as a means of increasing muscle strength or mass, either alone or combined with RT, in healthy elderly men; although GH...

  20. Non-Smoking Tobacco Affects Endothelial Function in Healthy Men in One of the Largest Health Studies Ever Performed; The Nord-Trøndelag Health Study in Norway; HUNT3

    Science.gov (United States)

    Aspenes, Stian Thoresen; Ellingsen, Øyvind

    2016-01-01

    Background Oral tobacco (snuff) is taking a large market share in Scandinavia, especially with young users. However, long-term health effects are unknown. Small studies show association between snuff and reduced endothelial function, representing an early stage of vascular injury that often precedes manifest cardiovascular disease by several years. We therefore determined the associations between snuff and endothelial function in a large sample of healthy Norwegian men. Methods and Design In the Fitness substudy of the Nord-Trøndelag Health Study (HUNT3), endothelial function was measured by flow-mediated dilation (FMD). Aerobic fitness was measured by peak oxygen uptake (VO2peak). A cross-sectional design including 1 592 self-reported healthy men compared these observations with records of present tobacco use, standard cardiovascular risk factors, and socioeconomic status, using general linear models. Results FMD was lower in snuff users (FMD: 4.12%, 3.63, 4.61) compared to non-users (FMD: 4.52%, 4.27, 4.78) after adjustment for age (difference: -0.57%, -1.12, -0.01). After further adjustment for potential confounders, FMD still tended to be lower in snuff users than in non-users (difference: -0.53%, -1.09, 0.02). This difference was even more pronounced in the inactive snuff users (-0.83%, -1.59, -0.06) and in the low fit snuff users (-0.74%, CI -0.55, 0.079). Conclusions Oral tobacco is associated with a tendency towards reduced endothelial function, indicating vascular changes that precede cardiovascular disease. The strongest associations were found in men with low physical activity or reduced aerobic fitness. PMID:27490361

  1. EFFECTS OF A NEW TESTOSTERONE TRANSDERMAL DELIVERY SYSTEM, BIOLIPID B2®-TESTOSTERONE IN HEALTHY MIDDLE AGED MEN: A CONFOCAL RAMAN SPECTROSCOPY STUDY

    Directory of Open Access Journals (Sweden)

    Marco Antonio Botelho

    2013-04-01

    Full Text Available The Transdermal Delivery System (BIOLIPID B2® is a nanoemulsion that can be applied directly to the skin by a metered pump to deliver hormones into the systemic circulation. The aims of this study were to assess the efficacy of BIOLIPID B2® to deliver testosterone systemically and evaluate the short-term effects on Thyroid-Stimulating Hormone (TSH, C-reactive protein (CRP serum levels and blood pressure in middle aged men with testosterone deficiency. An open label randomized prospective study enrolled 14 Brazilian middle aged men with testosterone deficiency. The volunteers received in the forearm 50mg of transdermal BIOLIPID B2®-testosterone nanostructured formulation daily for 3 months. Confocal Raman Spectroscopy (CRS was used to determine depth and concentration of testosterone on skin layers. Clinical parameters and serum concentrations were compared between the baseline and 3 months after treatment. Serum concentrations of testosterone, CPR and TSH changed significantly (p0.05 and no changes were observed in the blood pressure. No adverse events were attributed to this transdermal hormone replacement therapy protocol. The BIOLIPID B2® nanoemulsion formulation is safe and effective in reestablishing testosterone and Thyroid-Stimulating Hormone (TSH serum levels. This transdermal protocol may serve as a strategy for hormone replacement therapy in middle aged men.

  2. Healthy Weight, Healthy Child

    Science.gov (United States)

    ... page please turn Javascript on. Feature: Reducing Childhood Obesity Healthy Weight, Healthy Child Past Issues / Spring - Summer 2010 Table of Contents ... Summer_flyer_508.pdf Read More "Reducing Childhood Obesity" Articles Healthy Weight, Healthy Child / Get Involved How Parents and Kids Can Get ...

  3. Increasing protein intake modulates lipid metabolism in healthy young men and women consuming a high-fat hypercaloric diet 1-3

    NARCIS (Netherlands)

    Rietman, A.; Schwarz, J.; Blokker, B.A.; Siebelink, E.; Kok, F.J.; Afman, L.A.; Tome, D.; Mensink, M.R.

    2014-01-01

    The objective of this study was to evaluate the effect of increasing protein intake, at the expense of carbohydrates, on intrahepatic lipids (IHLs), circulating triglycerides (TGs), and body composition in healthy humans consuming a high-fat, hypercaloric diet. A crossover randomized trial with a pa

  4. Men's Health

    Science.gov (United States)

    ... men need to pay more attention to their health. Compared to women, men are more likely to ... regular checkups and medical care There are also health conditions that only affect men, such as prostate ...

  5. Vascular and inflammatory high fat meal responses in young healthy men; a discriminative role of IL-8 observed in a randomized trial.

    Directory of Open Access Journals (Sweden)

    Diederik Esser

    Full Text Available BACKGROUND: High fat meal challenges are known to induce postprandial low-grade inflammation and endothelial dysfunction. This assumption is largely based on studies performed in older populations or in populations with a progressed disease state and an appropriate control meal is often lacking. Young healthy individuals might be more resilient to such challenges. We therefore aimed to characterize the vascular and inflammatory response after a high fat meal in young healthy individuals. METHODS: In a double-blind randomized cross-over intervention study, we used a comprehensive phenotyping approach to determine the vascular and inflammatory response after consumption of a high fat shake and after an average breakfast shake in 20 young healthy subjects. Both interventions were performed three times. RESULTS: Many features of the vascular postprandial response, such as FMD, arterial stiffness and micro-vascular skin blood flow were not different between shakes. High fat/high energy shake consumption was associated with a more pronounced increase in blood pressure, heart rate, plasma concentrations of IL-8 and PBMCs gene expression of IL-8 and CD54 (ICAM-1, whereas plasma concentrations of sVCAM1 were decreased compared to an average breakfast. CONCLUSION: Whereas no difference in postprandial response were observed on classical markers of endothelial function, we did observe differences between consumption of a HF/HE and an average breakfast meal on blood pressure and IL-8 in young healthy volunteers. IL-8 might play an important role in dealing with high fat challenges and might be an early marker for endothelial stress, a stage preceding endothelial dysfunction.

  6. The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men

    DEFF Research Database (Denmark)

    Pilgaard, K; Jensen, C B; Schou, J H;

    2009-01-01

    h glucose, insulin and glucagon profiles; OGTT; mixed meal test; IVGTT; hyperglycaemic clamp with co-infusion of glucagon-like peptide (GLP)-1 or glucose-dependent insulinotropic polypeptide (GIP); and a euglycaemic-hyperinsulinaemic clamp combined with glucose tracer infusion to study hepatic and......-phase insulinotropic action of GLP-1 (p = 0.03) and GIP (p = 0.07) during a 7 mmol/l hyperglycaemic clamp. Secretion of GLP-1 and GIP during the mixed meal test was normal. Despite elevated hepatic glucose production, carriers of the T allele had significantly reduced 24 h glucagon concentrations (p < 0.02) suggesting......AIMS/HYPOTHESIS: We studied the physiological, metabolic and hormonal mechanisms underlying the elevated risk of type 2 diabetes in carriers of TCF7L2 gene. METHODS: We undertook genotyping of 81 healthy young Danish men for rs7903146 of TCF7L2 and carried out various beta cell tests including: 24...

  7. Effects of butter high in ruminant trans and monounsaturated fatty acids on lipoproteins, incorporation of fatty acids into lipid classes, plasma C-reactive protein, oxidative stress, hemostatic variables, and insulin in healthy young men

    DEFF Research Database (Denmark)

    Tholstrup, T.; Raff, M.; Basu, S.; Nonboe, P.; Sejrsen, K.; Straarup, Ellen Marie

    2006-01-01

    Background: Evidence suggests that ruminant trans fatty acids (FAs), such as vaccenic acid, do not increase the risk of ischemic heart disease (IHD). However, the effects of ruminant trans FAs on risk markers of IHD have been poorly investigated. Objective: The objective was to investigate the...... effect of butter with a naturally high content of vaccenic acid and a concomitantly higher content of monounsaturated FAs on classic and novel risk markers of IHD. Design: In a double-blind, randomized, 5-wk, parallel intervention study, 42 healthy young men were given 115 g fat/d from test butter that...... observed. Conclusions: Butter high in ruminant trans and monounsaturated FAs resulted in significantly lower total and HDL cholesterol than did the control butter with higher amounts of saturated FAs. It may be that the differences were due to the greater content of monounsaturated FAs and the lesser...

  8. s-ICAM-1 and s-VCAM-1 in healthy men are strongly associated with traits of the metabolic syndrome, becoming evident in the postprandial response to a lipid-rich meal

    Directory of Open Access Journals (Sweden)

    Nothnagel Michael

    2008-09-01

    Full Text Available Abstract Background The importance of the postprandial state for the early stages of atherogenesis is increasingly acknowledged. We conducted assessment of association between postprandial triglycerides, insulin and glucose after ingestion of a standardized lipid-rich test meal, and soluble cellular adhesion molecules (sCAM in young healthy subjects. Methods Metabolic parameters and sICAM-1, sVCAM-1 and E-selectin were measured before and hourly until 6 hours after ingestion of a lipid-rich meal in 30 healthy young men with fasting triglycerides 260 mg/dl. Levels of CAM were compared in HR and NR, and correlation with postprandial triglyceride, insulin and glucose response was assessed. Results Fasting sICAM-1 and sVCAM-1 levels were significantly higher in HR as compared to NR (p = 0.046, p = 0.03. For sE-selectin there was such a trend (p = 0.05. There was a strong positive and independent correlation between sICAM-1 and postprandial insulin maxima (r = 0.70, p Conclusion This independent association of postprandial triglycerides with sICAM-1 may indicate a particular impact of postprandial lipid metabolism on endothelial reaction.

  9. Association between GH receptor polymorphism (exon 3 deletion), serum IGF1, semen quality, and reproductive hormone levels in 838 healthy young men

    DEFF Research Database (Denmark)

    Andreassen, M; Jensen, Rikke Bodin; Jørgensen, Niels; Juul, Anders

    2014-01-01

    INTRODUCTION: GH activity may be involved in male reproductive function. A common genetic polymorphism in the gene encoding the GH receptor (GHR) results in deletion of the entire exon 3 sequence (GHRd3 isoform). The short GHRd3/d3 isoform seems more sensitive compared with full-length receptors...... (GHRfl/fl). AIM: TO INVESTIGATE THE ASSOCIATIONS BETWEEN GH ACTIVITY, EVALUATED BY EXON 3 GHR POLYMORPHISM, AND SERUM IGF1 VS REPRODUCTIVE HORMONES, SEMEN QUALITY, AND PRE- AND POSTNATAL GROWTH IN HEALTHY YOUNG MALES (N=838, MEAN AGE: 19.4 years). RESULTS: Compared with GHRfl/fl homozygous individuals (n...... genotype and serum IGF1 were not associated with size at birth or final height. CONCLUSIONS: GHRd3 polymorphism seemed only to have a weak influence on male reproductive function of borderline significance. The sensitive GHRd3/d3 genotype may slightly increase testicular function, as evaluated by semen...

  10. Effect of a high protein meat diet on muscle and cognitive functions: A randomised controlled dietary intervention trial in healthy men

    DEFF Research Database (Denmark)

    Jakobsen, Lene H.; Kondrup, Jens; Zellner, Maria;

    2011-01-01

    BackgroundRecommendations to use other criteria than N-balance for defining protein requirements have been proposed. However, little evidence to support other measures such as physiological functions is available. ObjectiveTo investigate the effects of a usual (UP) versus a high protein (HP) diet...... on muscle function, cognitive function, quality of life and biochemical regulators of protein metabolism. DesignA randomised intervention study was conducted with 23 healthy males (aged 19–31 yrs). All subjects consumed a Usual Protein (UP) diet (1.5 g protein/kg BW) for a 1-wk run-in period before...... the intervention period where they were assigned to either a UP or a High Protein (HP) diet (3.0 g protein/kg BW) for 3-wks with controlled intake of food and beverages. Blood and urine samples were taken along with measurements of physiological functions at baseline and at the end of the intervention...

  11. Acute effects of pea protein and hull fibre alone and combined on blood glucose, appetite, and food intake in healthy young men--a randomized crossover trial.

    Science.gov (United States)

    Mollard, Rebecca C; Luhovyy, Bohdan L; Smith, Christopher; Anderson, G Harvey

    2014-12-01

    Whether pulse components can be used as value-added ingredients in foods formulated for blood glucose (BG) and food intake (FI) control requires investigation. The objective of this study was to examine of the effects of pea components on FI at an ad libitum meal, as well as appetite and BG responses before and after the meal. In a repeated-measures crossover trial, men (n = 15) randomly consumed (i) pea hull fibre (7 g), (ii) pea protein (10 g), (iii) pea protein (10 g) plus hull fibre (7 g), (iv) yellow peas (406 g), and (v) control. Pea hull fibre and protein were served with tomato sauce and noodles, while yellow peas were served with tomato sauce. Control was noodles and tomato sauce. FI was measured at a pizza meal (135 min). Appetite and BG were measured pre-pizza (0-135 min) and post-pizza (155-215 min). Protein plus fibre and yellow peas led to lower pre-pizza BG area under the curve compared with fibre and control. At 30 min, BG was lower after protein plus fibre and yellow peas compared with fibre and control, whereas at 45 and 75 min, protein plus fibre and yellow peas led to lower BG compared with fibre (p yellow peas led to lower BG compared with fibre (p pea components as value-added ingredients in foods designed to improve glycemic control. PMID:25302637

  12. Screening of endocrine organ-specific humoral autoimmunity in 47,XXY Klinefelter's syndrome reveals a significant increase in diabetes-specific immunoreactivity in comparison with healthy control men.

    Science.gov (United States)

    Panimolle, Francesca; Tiberti, Claudio; Granato, Simona; Semeraro, Antonella; Gianfrilli, Daniele; Anzuini, Antonella; Lenzi, Andrea; Radicioni, Antonio

    2016-04-01

    The aim of this study was to evaluate the frequency of humoral endocrine organ-specific autoimmunity in 47,XXY Klinefelter's syndrome (KS) by investigating the autoantibody profile specific to type 1 diabetes (T1DM), Addison's disease (AD), Hashimoto thyroiditis (HT), and autoimmune chronic atrophic gastritis (AG). Sixty-one adult Caucasian 47,XXY KS patients were tested for autoantibodies specific to T1DM (Insulin Abs, GAD Abs, IA-2 Abs, Znt8 Abs), HT (TPO Abs), AD (21-OH Abs), and AG (APC Abs). Thirty-five of these patients were not undergoing testosterone replacement therapy TRT (Group 1) and the remaining 26 patients started TRT before the beginning of the study (Group 2). KS autoantibody frequencies were compared to those found in 122 control men. Six of 61 KS patients (9.8 %) were positive for at least one endocrine autoantibody, compared to 6.5 % of controls. Interestingly, KS endocrine immunoreactivity was directed primarily against diabetes-specific autoantigens (8.2 %), with a significantly higher frequency than in controls (p = 0.016). Two KS patients (3.3 %) were TPO Ab positive, whereas no patients were positive for AD- and AG-related autoantigens. The autoantibody endocrine profile of untreated and treated KS patients was not significantly different. Our findings demonstrate for the first time that endocrine humoral immunoreactivity is not rare in KS patients and that it is more frequently directed against type 1 diabetes-related autoantigens, thus suggesting the importance of screening for organ-specific autoimmunity in clinical practice. Follow-up studies are needed to establish if autoantibody-positive KS patients will develop clinical T1DM. PMID:25935328

  13. The SPECT tracer [123I]ADAM binds selectively to serotonin transporters: a double-blind, placebo-controlled study in healthy young men

    International Nuclear Information System (INIS)

    The tracer 123I-2-([2-({dimethylamino}methyl)phenyl]thio)-5-iodophenylamine ([123I]ADAM) has been developed to image serotonin transporters (SERTs) with SPECT. Preclinical studies have shown that [123I]ADAM binds selectively to SERTs. Moreover, initial human studies have shown that [123I]ADAM binding could be blocked by selective serotonin reuptake inhibitors (SSRIs). However, in humans it has not been proven that [123I]ADAM binds selectively to SERTs. We examined the in vivo availability of SERTs in 12 healthy young volunteers 5 h after bolus injection of [123I]ADAM. To evaluate the selectivity of binding, four participants were pretreated (double-blinded design) with placebo, four with paroxetine (20 mg) and four with the dopamine/norepinephrine blocker methylphenidate (20 mg). SPECT studies were performed on a brain-dedicated system (Neurofocus), and the SPECT images were coregistered with individual MR scans of the brain. ADAM binding in SERT-rich brain areas and cerebellar cortex (representing non-specific binding) was assessed by drawing regions of interest (ROIs) on the individual MR images. Specific to non-specific ratios were used as the outcome measure. We found that specific to non-specific ratios were statistically significantly lower in paroxetine-pretreated participants than in placebo- or methylphenidate-pretreated participants. No such difference was found between groups pretreated with placebo or methylphenidate. Our preliminary findings suggest that [123I]ADAM binds selectively to SERTs in human brain. (orig.)

  14. Effects of 16-week high-intensity interval training using upper and lower body ergometers on aerobic fitness and morphological changes in healthy men: a preliminary study

    Science.gov (United States)

    Osawa, Yusuke; Azuma, Koichiro; Tabata, Shogo; Katsukawa, Fuminori; Ishida, Hiroyuki; Oguma, Yuko; Kawai, Toshihide; Itoh, Hiroshi; Okuda, Shigeo; Matsumoto, Hideo

    2014-01-01

    It is unclear whether combined leg and arm high-intensity interval training (HIIT) improves fitness and morphological characteristics equal to those of leg-based HIIT programs. The aim of this study was to compare the effects of HIIT using leg-cycling (LC) and arm-cranking (AC) ergometers with an HIIT program using only LC. Effects on aerobic capacity and skeletal muscle were analyzed. Twelve healthy male subjects were assigned into two groups. One performed LC-HIIT (n=7) and the other LC- and AC-HIIT (n=5) twice weekly for 16 weeks. The training programs consisted of eight to 12 sets of >90% VO2 (the oxygen uptake that can be utilized in one minute) peak for 60 seconds with a 60-second active rest period. VO2 peak, watt peak, and heart rate were measured during an LC incremental exercise test. The cross-sectional area (CSA) of trunk and thigh muscles as well as bone-free lean body mass were measured using magnetic resonance imaging and dual-energy X-ray absorptiometry. The watt peak increased from baseline in both the LC (23%±38%; PHIIT program improves aerobic capacity and muscle hypertrophy in both leg and trunk muscles. PMID:25395872

  15. The effect of yellow pea protein and fibre on short-term food intake, subjective appetite and glycaemic response in healthy young men.

    Science.gov (United States)

    Smith, Christopher E; Mollard, Rebecca C; Luhovyy, Bohdan L; Anderson, G Harvey

    2012-08-01

    Pulses are low-glycaemic foods rich in protein (20-25 %), resistant starch and fibre that suppress appetite and glycaemia. The objective of the present study was to elucidate the component(s) of yellow peas responsible for these benefits and assess their efficacy as value-added food ingredients. We investigated the effects of 10 or 20 g of isolated yellow pea protein (P10 and P20) or fibre (F10 and F20) on food intake (FI) at an ad libitum pizza meal served at 30 min (Expt 1, n 19) or 120 min (Expt 2, n 20) and blood glucose (BG) and appetite in young, healthy males (20-30 years). In Expt 1, P20 led to lower FI than control (4937 (sem 502) v. 5632 (sem 464) kJ (1180 (sem 120) v. 1346 (sem 111) kcal)) and all other treatments (P yellow peas in the regulation of glycaemia and FI, but its second-meal effects disappear by 2 h post-consumption. PMID:22916818

  16. The SPECT tracer [{sup 123}I]ADAM binds selectively to serotonin transporters: a double-blind, placebo-controlled study in healthy young men

    Energy Technology Data Exchange (ETDEWEB)

    Giessen, Elsmarieke van de [University of Amsterdam, Academic Medical Center, Graduate School Neurosciences Amsterdam, Department of Nuclear Medicine, Amsterdam (Netherlands); Booij, Jan [University of Amsterdam, Academic Medical Center, Graduate School Neurosciences Amsterdam, Department of Nuclear Medicine, Amsterdam (Netherlands); University of Amsterdam, Academic Medical Center, Department of Nuclear Medicine, F2-236, Amsterdam (Netherlands)

    2010-08-15

    The tracer {sup 123}I-2-([2-({l_brace}dimethylamino{r_brace}methyl)phenyl]thio)-5-iodophenylamine ([{sup 123}I]ADAM) has been developed to image serotonin transporters (SERTs) with SPECT. Preclinical studies have shown that [{sup 123}I]ADAM binds selectively to SERTs. Moreover, initial human studies have shown that [{sup 123}I]ADAM binding could be blocked by selective serotonin reuptake inhibitors (SSRIs). However, in humans it has not been proven that [{sup 123}I]ADAM binds selectively to SERTs. We examined the in vivo availability of SERTs in 12 healthy young volunteers 5 h after bolus injection of [{sup 123}I]ADAM. To evaluate the selectivity of binding, four participants were pretreated (double-blinded design) with placebo, four with paroxetine (20 mg) and four with the dopamine/norepinephrine blocker methylphenidate (20 mg). SPECT studies were performed on a brain-dedicated system (Neurofocus), and the SPECT images were coregistered with individual MR scans of the brain. ADAM binding in SERT-rich brain areas and cerebellar cortex (representing non-specific binding) was assessed by drawing regions of interest (ROIs) on the individual MR images. Specific to non-specific ratios were used as the outcome measure. We found that specific to non-specific ratios were statistically significantly lower in paroxetine-pretreated participants than in placebo- or methylphenidate-pretreated participants. No such difference was found between groups pretreated with placebo or methylphenidate. Our preliminary findings suggest that [{sup 123}I]ADAM binds selectively to SERTs in human brain. (orig.)

  17. Effects of moderate-intensity aerobic cycling and swim exercise on post-exertional blood pressure in healthy young untrained and triathlon-trained men and women.

    Science.gov (United States)

    Lakin, Robert; Notarius, Catherine; Thomas, Scott; Goodman, Jack

    2013-12-01

    Aerobic exercises such as running, walking and cycling are known to elicit a PEH (post-exercise hypotensive) response in both trained and UT (untrained) subjects. However, it is not known whether swim exercise produces a similar effect in normotensive individuals. The complex acute physiological responses to water immersion suggest swimming may affect BP (blood pressure) differently than other forms of aerobic exercises. We tested the hypothesis that an acute bout of swimming would fail to elicit a PEH BP response compared with an equivalent bout of stationary cycling, regardless of training state. We studied 11 UT and ten triathlon-trained young healthy normotensive [SBP/DBP (systolic BP/diastolic BP) swimming sessions to assess changes in BP during a 75-min seated recovery. CO (cardiac output), SV (stroke volume), TPR (total peripheral resistance), HR (heart rate), HRV (HR variability) and core and skin temperature were also assessed. In UT subjects, PEH was similar between cycling (-3.1±1 mmHg) and swimming (-5.8±1 mmHg), with the greater magnitude of PEH following swimming, reflecting a significant fall in SV between modalities (PTrained individuals did not exhibit a PEH response following swimming (0.3±1 mmHg), yet had a significant fall in SBP at 50 min post-cycling exercise (-3.7±1 mmHg) (Pswimming in the trained group may reflect a higher cardiac sympathetic outflow [as indicated by the LF (low-frequency) spectral component of HRV) (25 and 50 min) (Ptraining may limit the potential for an effective post-exertional hypotensive response to aerobic swimming. PMID:23763298

  18. Healthy Mouth, Healthy Body

    Science.gov (United States)

    FOR THE DENTAL PATIENT ... Healthy mouth, healthy body T he mouth is a window into the health of the body. It can show signs of nutri- tional ... Sjögren’s syndrome—may first become apparent because of mouth lesions or other oral problems. The mouth is ...

  19. Effects of 16-week high-intensity interval training using upper and lower body ergometers on aerobic fitness and morphological changes in healthy men: a preliminary study

    Directory of Open Access Journals (Sweden)

    Osawa Y

    2014-11-01

    Full Text Available Yusuke Osawa,1,2,* Koichiro Azuma,3,* Shogo Tabata,3 Fuminori Katsukawa,2 Hiroyuki Ishida,2 Yuko Oguma,2 Toshihide Kawai,4 Hiroshi Itoh,4 Shigeo Okuda,5 Hideo Matsumoto3 1Japan Society for the Promotion of Science, Graduate School of Arts and Sciences, University of Tokyo, Tokyo, Japan; 2Sports Medicine Research Center, Keio University, Kanagawa, Japan; 3Institute for Integrated Sports Medicine, School of Medicine, Keio University, Tokyo, Japan; 4Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan; 5Department of Radiology, School of Medicine, Keio University, Tokyo, Japan *Yusuke Osawa and Koichiro Azuma are co-first authors of this article Abstract: It is unclear whether combined leg and arm high-intensity interval training (HIIT improves fitness and morphological characteristics equal to those of leg-based HIIT programs. The aim of this study was to compare the effects of HIIT using leg-cycling (LC and arm-cranking (AC ergometers with an HIIT program using only LC. Effects on aerobic capacity and skeletal muscle were analyzed. Twelve healthy male subjects were assigned into two groups. One performed LC-HIIT (n=7 and the other LC- and AC-HIIT (n=5 twice weekly for 16 weeks. The training programs consisted of eight to 12 sets of >90% VO2 (the oxygen uptake that can be utilized in one minute peak for 60 seconds with a 60-second active rest period. VO2 peak, watt peak, and heart rate were measured during an LC incremental exercise test. The cross-sectional area (CSA of trunk and thigh muscles as well as bone-free lean body mass were measured using magnetic resonance imaging and dual-energy X-ray absorptiometry. The watt peak increased from baseline in both the LC (23%±38%; P<0.05 and the LC–AC groups (11%±9%; P<0.05. The CSA of the quadriceps femoris muscles also increased from baseline in both the LC (11%±4%; P<0.05 and the LC–AC groups (5%±5%; P<0.05. In contrast, increases were observed in the CSA of

  20. 血友病男性患者与健康男性龈沟出血指数的比较%Comparison of sulcus bleeding index between male patients with hemophil-ia and healthy men

    Institute of Scientific and Technical Information of China (English)

    黄劲

    2015-01-01

    Objective To compare the difference of sulcus bleeding index between male patients with hemophilia and healthy men,analyze the correlationshiip between hemorrhage and oral hygiene. Methods 120 male patients with hemophilia admitted into our hospital from May 2011 to March 2014 were selected as observation objects (hemophilia group),were divided into group of age less than 35 years old (n=67) and group of age more than 35 years old (n=53).30 healthy men for check-up at the same period were selected as control group.Sulcus bleeding index was examined and dental plaque and calculus index in hemophilia group was observed. Results The sulcus bleeding index in hemophilia group was 1.78±1.32,higher than 1.61±1.00 in the control group,the difference was significant (P35岁组(53例),以同期入院接受全口牙龈沟出血指数检查的30例健康男性体检者为对照组。对两组均进行全口牙龈沟出血指数检测,并观察血友病组菌斑指数、牙石指数。结果血友病男性患者齿龈沟出血指数为1.78±1.32,高于对照组的1.61±1.00,差异有统计学意义(P35岁患者组的齿龈沟出血指数,差异有统计学意义(P<0.05)。血友病患者的菌斑指数、牙石指数与齿龈沟出血指数呈正相关。结论血友病患者出血严重程度与年龄有关,注意口腔卫生能减少牙龈出血。

  1. 11C-ORM-13070, a novel PET ligand for brain α2C-adrenoceptors: radiometabolism, plasma pharmacokinetics, whole-body distribution and radiation dosimetry in healthy men

    International Nuclear Information System (INIS)

    11C-labelled 1-[(S)-1-(2,3-dihydrobenzo[1,2]dioxin-2-yl)methyl] -4-(3-methoxy-methylpyridin-2- yl)-piperazine (11C-ORM-13070) is a novel PET tracer for imaging of α2C-adrenoceptors in the human brain. Brain α2C-adrenoceptors may be therapeutic targets in several neuropsychiatric disorders, including depression, schizophrenia and Alzheimer's disease. To validate the use of 11C-ORM-13070 in humans, we investigated its radiometabolism, pharmacokinetics, whole-body distribution and radiation dose. Radiometabolism was studied in a test-retest setting in six healthy men. After intravenous injection of 11C-ORM-13070, blood samples were drawn over 60 min. Plasma samples were analysed by radio-HPLC for intact tracer and its radioactive metabolites. Metabolite-corrected plasma time-activity curves were used for calculation of pharmacokinetics. In a separate group of 12 healthy men, the whole-body distribution of 11C-ORM-13070 and radiation exposure were investigated by dynamic PET/CT imaging without blood sampling. Two radioactive metabolites of 11C-ORM-13070 were detected in human arterial plasma. The proportion of unchanged 11C-ORM-13070 decreased from 81 ± 4 % of total radioactivity at 4 min after tracer injection to 23 ± 4 % at 60 min. At least one of the radioactive metabolites penetrated into red blood cells, while the parent tracer remained in plasma. The apparent elimination rate constant and corresponding half-life of unchanged 11C-ORM-13070 in arterial plasma were 0.0117 ± 0.0056 min-1 and 73.6 ± 35.8 min, respectively. The organs with the highest absorbed doses were the liver (12 μSv/MBq), gallbladder wall (12 μSv/MBq) and pancreas (9.1 μSv/MBq). The mean effective dose was 3.9 μSv/MBq, with a range of 3.6 - 4.2 μSv/MBq. 11C-ORM-13070 was rapidly metabolized in human subjects after intravenous injection. The effective radiation dose of 11C-ORM-13070 was in the same range as that of other 11C-labelled brain receptor tracers. An injection of 500 MBq of 11

  2. More men than women make mucosal IgA antibodies to Human papillomavirus type 16 (HPV-16 and HPV-18: a study of oral HPV and oral HPV antibodies in a normal healthy population

    Directory of Open Access Journals (Sweden)

    Van Der Walt Eric

    2006-06-01

    Full Text Available Abstract Background We have previously shown the high prevalence of oral anti-human papillomavirus type 16 (HPV-16 antibodies in women with HPV-associated cervical neoplasia. It was postulated that the HPV antibodies were initiated after HPV antigenic stimulation at the cervix via the common mucosal immune system. The present study aimed to further evaluate the effectiveness of oral fluid testing for detecting the mucosal humoral response to HPV infection and to advance our limited understanding of the immune response to HPV. Methods The prevalence of oral HPV infection and oral antibodies to HPV types 16, 18 and 11 was determined in a normal, healthy population of children, adolescents and adults, both male and female, attending a dental clinic. HPV types in buccal cells were determined by DNA sequencing. Oral fluid was collected from the gingival crevice of the mouth by the OraSure method. HPV-16, HPV-18 and HPV-11 antibodies in oral fluid were detected by virus-like particle-based enzyme-linked immunosorbent assay. As a reference group 44 women with cervical neoplasia were included in the study. Results Oral HPV infection was highest in children (9/114, 7.9%, followed by adolescents (4/78, 5.1%, and lowest in normal adults (4/116, 3.5%. The predominant HPV type found was HPV-13 (7/22, 31.8% followed by HPV-32 (5/22, 22.7%. The prevalence of oral antibodies to HPV-16, HPV-18 and HPV-11 was low in children and increased substantially in adolescents and normal adults. Oral HPV-16 IgA was significantly more prevalent in women with cervical neoplasia (30/44, 68.2% than the women from the dental clinic (18/69, 26.1% P = 0.0001. Significantly more adult men than women displayed oral HPV-16 IgA (30/47 compared with 18/69, OR 5.0, 95% CI 2.09–12.1, P Conclusion The increased prevalence of oral HPV antibodies in adolescent individuals compared with children was attributed to the onset of sexual activity. The increased prevalence of oral anti-HPV Ig

  3. PlanHab: the combined and separate effects of 16 days of bed rest and normobaric hypoxic confinement on circulating lipids and indices of insulin sensitivity in healthy men.

    Science.gov (United States)

    Simpson, Elizabeth J; Debevec, Tadej; Eiken, Ola; Mekjavic, Igor; Macdonald, Ian A

    2016-04-15

    PlanHab is a planetary habitat simulation study. The atmosphere within future space habitats is anticipated to have reduced Po2, but information is scarce as to how physiological systems may respond to combined exposure to moderate hypoxia and reduced gravity. This study investigated, using a randomized-crossover design, how insulin sensitivity, glucose tolerance, and circulating lipids were affected by 16 days of horizontal bed rest in normobaric normoxia [NBR: FiO2 = 0.209; PiO2 = 133.1 (0.3) mmHg], horizontal bed rest in normobaric hypoxia [HBR: FiO2 = 0.141 (0.004); PiO2 = 90.0 (0.4) mmHg], and confinement in normobaric hypoxia combined with daily moderate intensity exercise (HAMB). A mixed-meal tolerance test, with arterialized-venous blood sampling, was performed in 11 healthy, nonobese men (25-45 yr) before (V1) and on the morning ofday 17of each intervention (V2). Postprandial glucose and c-peptide response were increased at V2 of both bed rest interventions (PHypoxia did not alter the adverse effects of bed rest on insulin sensitivity and glucose tolerance but appeared to increase insulin clearance. The negative effect of bed rest on HDL was compounded in hypoxia, which may have implications for long-term health of those living in future space habitats. PMID:26769956

  4. GH administration changes myosin heavy chain isoforms in skeletal muscle but does not augment muscle strength or hypertrophy, either alone or combined with resistance exercise training in healthy elderly men

    DEFF Research Database (Denmark)

    Lange, Kai Henrik Wiborg; Andersen, Jesper Løvind; Beyer, Nina;

    2002-01-01

    GH administration, either alone or combined with resistance exercise training (RT), has attracted interest as a means of increasing muscle mass and strength in the elderly. In the present study, 31 healthy, elderly men [age, 74 +/- 1 yr (mean +/- SEM)] were assigned to either RT [3 sessions/wk, 3......-5 sets of 8-12 repetition maximum (RM)/session] + placebo (n = 8), RT + GH (n = 8), GH (n = 8), or placebo (n = 7) in a randomized, placebo-controlled, double-blinded (RT + placebo and RT + GH) or single-blinded (GH or placebo) design. Measurements of: 1) isokinetic quadriceps muscle strength; 2...... baseline and after 12 wk. The final GH dose was 1.77 +/- 0.18 IU x d(-1) (approximately 7.2 +/- 0.8 microg x kg(-1) x d(-1)). GH alone had no effect on isokinetic quadriceps muscle strength, power, CSA, or fiber size. However, a substantial increase in MHC 2X isoform was observed with GH administration...

  5. Deficiencia de glucosa 6-fostato deshidrogenasa en hombres sanos y en pacientes maláricos; Turbo (Antioquia, Colombia Deficiency of glucose-6-phosphate dehydrogenase in healthy men and malaria patients; Turbo (Antioquia, Colombia

    Directory of Open Access Journals (Sweden)

    Jaime Carmona-Fonseca

    2008-06-01

    interval (IC95%, the mean values were between 4.15 and 4.51 IU/g hemoglobin; 14.8% exhibited values below "normal", i.e. < 2.29 IU/g hemoglobin (G6PD prevalence. Among malaria-infected men (n = 206 IC95% ranged from 3.81 to 4.16, and among malaria infected women, it ranged from 3.86 to 4.20 IU/g of hemoglobin. The mean values observed in males (healthy vs. infected were statistically different (p = 0.028. Only 9.5% (13/137 of the infected individuals, had G6PD deficiency and this occurred only within the male group. CONCLUSIONS: G6PD is relatively high among healthy people (14.8% and in the P. vivax infected (9.5% male population of Turbo.

  6. Tuberculosis: Getting Healthy, Staying Healthy

    Science.gov (United States)

    Tuberculosis Getting Healthy, Staying Healthy U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Allergy and Infectious Diseases Tuberculosis Getting Healthy, Staying Healthy U.S. DEPARTMENT OF HEALTH ...

  7. Men: Stay Healthy at Any Age

    Science.gov (United States)

    ... Task Force Improving Primary Care Practice Health IT Integration Health Care/System Redesign Clinical-Community Linkages Care Coordination Capacity Building Behavioral and Mental Health Self-Management Support Resources Clinical Community Relationships ...

  8. {sup 11}C-ORM-13070, a novel PET ligand for brain α{sub 2C}-adrenoceptors: radiometabolism, plasma pharmacokinetics, whole-body distribution and radiation dosimetry in healthy men

    Energy Technology Data Exchange (ETDEWEB)

    Luoto, Pauliina; Oikonen, Vesa; Arponen, Eveliina; Helin, Semi; Virta, Jere; Virtanen, Kirsi; Roivainen, Anne [University of Turku and Turku University Hospital, Turku PET Centre, Turku (Finland); Suilamo, Sami [University of Turku and Turku University Hospital, Turku PET Centre, Turku (Finland); Turku University Hospital, Department of Oncology and Radiotherapy, Turku (Finland); Herttuainen, Jukka; Hietamaeki, Johanna; Holopainen, Aila; Rouru, Juha; Sallinen, Jukka [Orion Pharma, Espoo and Turku (Finland); Kailajaervi, Marita [GE Healthcare, Turku Imanet, Turku (Finland); Peltonen, Juha M.; Scheinin, Mika; Volanen, Iina [University of Turku, CRST, Turku (Finland); Rinne, Juha O. [University of Turku and Turku University Hospital, Turku PET Centre, Turku (Finland); University of Turku, CRST, Turku (Finland); TYKSLAB, Unit of Clinical Pharmacology, Turku (Finland); University of Turku and Turku University Hospital, Division of Clinical Neurosciences, Turku (Finland)

    2014-10-15

    {sup 11}C-labelled 1-[(S)-1-(2,3-dihydrobenzo[1,2]dioxin-2-yl)methyl] -4-(3-methoxy-methylpyridin-2- yl)-piperazine ({sup 11}C-ORM-13070) is a novel PET tracer for imaging of α{sub 2C}-adrenoceptors in the human brain. Brain α{sub 2C}-adrenoceptors may be therapeutic targets in several neuropsychiatric disorders, including depression, schizophrenia and Alzheimer's disease. To validate the use of {sup 11}C-ORM-13070 in humans, we investigated its radiometabolism, pharmacokinetics, whole-body distribution and radiation dose. Radiometabolism was studied in a test-retest setting in six healthy men. After intravenous injection of {sup 11}C-ORM-13070, blood samples were drawn over 60 min. Plasma samples were analysed by radio-HPLC for intact tracer and its radioactive metabolites. Metabolite-corrected plasma time-activity curves were used for calculation of pharmacokinetics. In a separate group of 12 healthy men, the whole-body distribution of {sup 11}C-ORM-13070 and radiation exposure were investigated by dynamic PET/CT imaging without blood sampling. Two radioactive metabolites of {sup 11}C-ORM-13070 were detected in human arterial plasma. The proportion of unchanged {sup 11}C-ORM-13070 decreased from 81 ± 4 % of total radioactivity at 4 min after tracer injection to 23 ± 4 % at 60 min. At least one of the radioactive metabolites penetrated into red blood cells, while the parent tracer remained in plasma. The apparent elimination rate constant and corresponding half-life of unchanged {sup 11}C-ORM-13070 in arterial plasma were 0.0117 ± 0.0056 min{sup -1} and 73.6 ± 35.8 min, respectively. The organs with the highest absorbed doses were the liver (12 μSv/MBq), gallbladder wall (12 μSv/MBq) and pancreas (9.1 μSv/MBq). The mean effective dose was 3.9 μSv/MBq, with a range of 3.6 - 4.2 μSv/MBq. {sup 11}C-ORM-13070 was rapidly metabolized in human subjects after intravenous injection. The effective radiation dose of {sup 11}C-ORM-13070 was in the same range

  9. Marketing a Healthy Mind, Body, and Soul: An Analysis of How African American Men View the Church as a Social Marketer and Health Promoter of Colorectal Cancer Risk and Prevention

    Science.gov (United States)

    Lumpkins, Crystal Y.; Vanchy, Priya; Baker, Tamara A.; Daley, Christine; Ndikum-Moffer, Florence; Greiner, K. Allen

    2016-01-01

    The Centers for Disease Control and Prevention ranks colorectal cancer (CRC) as the third most commonly diagnosed cancer among men in the United States; African American (AA) men are at even greater risk. The present study was from a larger study that investigates the church's role as a social marketer of CRC risk and prevention messages, and…

  10. Clinical observation of penis lengthening surgery of 77 cases of healthy adult men%成年健康男性77例阴茎延长术的临床观察

    Institute of Scientific and Technical Information of China (English)

    吴洪斌

    2012-01-01

    目的 通过阴茎延长术达到阴茎延长的目的,满足患者性心理和性生理的需求,提高生活质量.方法 选择22~60周岁成年健康男性,平均年龄38.3周岁,阴茎自然状态下小于4 cm,平均(2.5±1) cm.选择对象不包括性腺发育异常,先天性睾丸发育不全综合征, (细胞核型分析47XXY)等先天性性腺,性器官发育异常所导致的阴茎短小患者.耻骨前正中直切口长3 cm左右,达男性性生殖三角顶端后,沿生殖三角皮肤外侧缘做V型切口至阴茎根部左右两侧平3点,9点钟处.依次切开皮肤、皮下,分离阴茎三角,切断阴茎浅悬韧带,深悬韧带切断1/3~2/3,充分松解释放阴茎体.结果 77例患者手术顺利,除一例患者切口延期愈合外,其余患者均一期愈合.5例患者出现阴囊水肿,术后20 d左右消失.阴茎在自然状态下体外部分达到(6±1.5) cm.延长3~5 cm,平均4 cm.所有患者对手术效果满意.结论 随着物质生活水平的提高,对生殖器大小及性生活质量要求也随之提高.通过阴茎延长术可以满足这部分患者的性心理和性生理的需求,提高生活质量.%OBJECTIVE To observe the clinical effect of the penis lengthening surgery in order to kown the sex psychology and sex physiology requirements of the patients and improve their life quality. METHODS The healthy adult men were chosen. Their ages ranged from 22 to 60,-and the average age was 38.3 years. Their penises were less than 4cm in the natural state and the average length was 2.5±lcm. The selected subjects didn' t include the men with the abnormal gonad, the congenital aplastic testis syndrome, and the short penis caused by the congenital dysplasia of the gonad (the cell karyotype 47XXY) and the dys-plasia of the sexual organs. The straight incision in the middle of the front surface of the pubis was 3cm or so, and the V-shape incision was made till the planar points at 3 clock and 9 clock on the left and right sides of

  11. Healthy Eating

    Science.gov (United States)

    ... Story" 5 Things to Know About Zika & Pregnancy Healthy Eating KidsHealth > For Parents > Healthy Eating Print A A A Text Size What's in ... new foods and to be role models for healthy eating. Teens may turn up their noses at the ...

  12. Working towards Men's Health: Findings from the Sefton Men's Health Project

    Science.gov (United States)

    Robinson, Mark; Robertson, Steve; McCullagh, Jo; Hacking, Sue

    2010-01-01

    Objective: To evaluate a health improvement initiative aimed at enhancing the health of men in deprived areas. Design: A healthy lifestyle programme was undertaken with men to increase their health knowledge, and encourage behaviour modification and access to health improvement services. A peer mentoring programme was implemented and a training…

  13. Healthy Sexuality

    Medline Plus

    Full Text Available ... sexual response in men. During arousal, a man’s penis becomes filled with blood, causing it to rise ... of clear liquid at the tip of the penis. While all this is happening, many other changes ...

  14. Marketing a Healthy Mind, Body, and Soul: An Analysis of How African American Men View the Church as a Social Marketer and Health Promoter of Colorectal Cancer Risk and Prevention.

    Science.gov (United States)

    Lumpkins, Crystal Y; Vanchy, Priya; Baker, Tamara A; Daley, Christine; Ndikum-Moffer, Florence; Greiner, K Allen

    2016-08-01

    The Centers for Disease Control and Prevention ranks colorectal cancer (CRC) as the third most commonly diagnosed cancer among men in the United States; African American (AA) men are at even greater risk. The present study was from a larger study that investigates the church's role as a social marketer of CRC risk and prevention messages, and whether religiously targeted and tailored health promotion materials will influence screening outcome. We used an integrated theoretical approach to explore participants' perceptions of CRC risk and prevention and how promotion messages should be developed and socially marketed by the church. Six focus groups were conducted with men from predominately AA churches in the Midwest. Themes from focus group discussions showed participants lacked knowledge about CRC, feared cancer diagnosis, and feared the procedure for screening. Roles of masculinity and the mistrust of physicians were also emergent themes. Participants did perceive the church as a trusted marketer of CRC but believed that promotional materials should be cosponsored and codeveloped by reputable health organizations. Employing the church as a social marketer of CRC screening promotion materials may be useful in guiding health promotions and addressing barriers that are distinct among African American men. PMID:26424748

  15. Healthy Sexuality

    Medline Plus

    Full Text Available ... upbringing. Sex is an important part of your life and sexual concerns should be taken seriously. When ... Everyone can achieve the healthy and satisfying sex life that they deserve. Looking for Additional Information? Visit ...

  16. Healthy Sexuality

    Medline Plus

    Full Text Available ... Healthy Sexuality Sexuality is the experience and/or expression of a person as a sexual being. Sexuality ... and explanations. Sexuality is the experience and/or expression of a person as a sexual being. It ...

  17. Healthy Ageing

    OpenAIRE

    Schans, Cees van der

    2015-01-01

    Presentatie gehouden bij de bijeenkomst voor het Regionaal Genootschap Fysiotherapie Het Noorden op 10 februari te Marum, over het belang van fysieke activiteit voor healthy ageing en de rol van de fysiotherapeut hierin

  18. Healthy Living

    Science.gov (United States)

    ... Environment Kids Health Topics Environment & Health Healthy Living Pollution Reduce, Reuse, Recycle Science – How It Works The ... the Label, Mabel Easy Steps to Better Health! Skin Wise All about an important part of your ...

  19. Healthy Sexuality

    Medline Plus

    Full Text Available ... t be afraid to talk with a health care professional. Everyone can achieve the healthy and satisfying ... site at www.asrm.org Find a Health Care Provider Back to Top Home | About Us | Reproductive ...

  20. Healthy Sexuality

    Medline Plus

    Full Text Available ... woman’s nipples become erect, her blood pressure and heart rate increase, and a “sex flush” from the ... all this is happening, many other changes occur: heart rate and blood pressure increase and some men ...

  1. Healthy Sexuality

    Medline Plus

    Full Text Available ... woman’s nipples become erect, her blood pressure and heart rate increase, and a “sex flush” from the stomach ... all this is happening, many other changes occur: heart rate and blood pressure increase and some men also ...

  2. Healthy Sexuality

    Medline Plus

    Full Text Available ... esteem, and cardiovascular health. A person’s physical sexual response is an important part of his or her ... There are also physical changes during the sexual response in men. During arousal, a man’s penis becomes ...

  3. Spirometry in healthy elderly Chinese.

    OpenAIRE

    Woo, J.; Pang, J

    1988-01-01

    Forced expiratory volume (FEV1), forced vital capacity (FVC), and peak expiratory flow (PEF) were measured in healthy subjects (129 men, 210 women) aged 60 years and above who were leading an independent and active life in the community. Women but not men showed an age related decline in FEV1 and FVC. Correlations of FEV1 and FVC with height were weaker than those reported for all age groups. Male ex-smokers had lower FEV1 values than current smokers and non-smokers. Regression equations are ...

  4. [The experience of men with hypertension].

    Science.gov (United States)

    Leclerc, Anne-Marie; De Montigny, Francine; Cloutier, Lyne

    2015-01-01

    Many studies show that men make specific lifestyle choices. However, regarding high blood pressure (HBP), guidelines are without distinction for gender. The purpose of this project is to explore the men's experience with HBP. Using a phenomenological design, semi-structured interviews were conducted with ten men living with HBP to explore beliefs and perceptions of men living with HBP. The main framework used is the health belief model. Two themes emerged: the meaning given to HBP (an unavoidable disease, the trivialization of HBP et HBP as synonymous of stress) and the management of this illness (the notion of control, the paradox of knowing about what to do and implementation of healthy lifestyle, relationship with health professionals). These results bring a better understanding of the experience of men with hypertension. PMID:26333268

  5. Biliverdin Reductase-A correlates with inducible nitric oxide synthasein in atorvastatin treated aged canine brain

    Institute of Scientific and Technical Information of China (English)

    Fabio Di Domenico; Marzia Perluigi; Eugenio Barone

    2013-01-01

    Alzheimer’s disease is a neurodegenerative disorder characterized by progressive cognitive impairment and neuropathology. Recent preclinical and epidemiological studies proposed statins as a possible therapeutic drug for Alzheimer’s disease, but the exact mechanisms of action are stil unknown. Biliverdin reductase-A is a pleiotropic enzyme involved in cel ular stress responses. It not only transforms biliverdin-IX alpha into the antioxidant bilirubin-IX alpha but its serine/threonine/tyrosine kinase activity is able to modulate cel signaling networks. We previously reported the beneficial effects of atorvastatin treatment on biliverdin reductase-A and heme oxygenase-1 in the brains of a well characterized pre-clinical model of Alzheimer’s disease, aged beagles, together with observed improvement in cognition. Here we extend our knowledge of the effects of atorvastatin on inducible nitric oxide synthase in parietal cortex, cerebel um and liver of the same animals. We demonstrated that atorvastatin treatment (80 mg/day for 14.5 months) to aged beagles selectively increased inducible nitric oxide synthase in the parietal cortex but not in the cerebel um. In contrast, inducible nitric oxide synthase protein levels were significantly decreased in the liver. Significant positive correlations were found between biliverdin reductase-A and inducible nitric oxide synthase as wel as heme oxygenase-1 protein levels in the parietal cortex. The opposite was observed in the liver. Inducible nitric oxide synthase up-regulation in the parietal cortex was positively associated with improved biliverdin reductase-A functions, whereas the oxidative-induced impairment of biliverdin reductase-A in the liver negatively affected inducible nitric oxide synthase expression, thus suggesting a role for biliverdin reductase-A in atorvastatin-dependent inducible nitric oxide synthase changes. Interestingly, increased inducible nitric oxide synthase levels in the parietal cortex were not associated with higher oxidative/nitrosative stress levels. We hypothesize that biliverdin reductase-A-dependent inducible nitric oxide synthase regulation strongly contributes to the cognitive improvement observed fol owing atorvastatin treatment.

  6. Healthy Places

    Centers for Disease Control (CDC) Podcasts

    2007-04-10

    Every person has a stake in environmental public health. As the environment deteriorates, so does the physical and mental health of the people within it. Healthy places are those designed and built to improve the quality of life for all people who live, work, worship, learn, and play within their borders -- where every person is free to make choices amid a variety of healthy, available, accessible, and affordable options. The CDC recognizes significant health issues and places that are vital in developing the Healthy Places program and provides examples in this report.  Created: 4/10/2007 by CDC National Center for Environmental Health.   Date Released: 4/13/2007.

  7. Healthy Sexuality

    Medline Plus

    Full Text Available ... don’t be afraid to talk with a health care professional. Everyone can achieve the healthy and satisfying ... provider site at www.asrm.org Find a Health Care Provider Back to Top Home | About Us | Reproductive ...

  8. Healthy Sexuality

    Medline Plus

    Full Text Available ... Smoking Cessation Links to Professional Societies and Organizations Home › Healthy Sexuality Sexuality is the experience and/or ... Find a Health Care Provider Back to Top Home | About Us | Reproductive Health Topics | News & Publications | Resources ...

  9. Healthy Sexuality

    Medline Plus

    Full Text Available ... healthy and satisfying sex life that they deserve. Looking for Additional Information? Visit our provider site at www.asrm.org Find a Health Care Provider Back to Top Home | About Us | Reproductive Health Topics | News & Publications | Resources ...

  10. Healthy Sexuality

    Medline Plus

    Full Text Available ... Links to Professional Societies and Organizations Home › Healthy Sexuality Sexuality is the experience and/or expression of ... is an important part of his or her sexuality. Let’s talk about how a woman’s body responds ...

  11. Healthy Sexuality

    Science.gov (United States)

    ... Links to Professional Societies and Organizations Home › Healthy Sexuality Sexuality is the experience and/or expression of ... is an important part of his or her sexuality. Let’s talk about how a woman’s body responds ...

  12. Healthy Sexuality

    Medline Plus

    Full Text Available ... and Smoking Cessation Links to Professional Societies and Organizations Home › Healthy Sexuality Sexuality is the experience and/ ... the course of a lifetime. The World Health Organization has defined sexual health as “…a state of ...

  13. 健康男性直肠周围筋膜的CT和MRI影像学观察%Observation on computed tomographic and magnetic resonance images of perirectal fasciae of healthy men

    Institute of Scientific and Technical Information of China (English)

    张策; 成官迅; 李国新; 钟世镇

    2012-01-01

    目的 阐明健康男性直肠周围筋膜和神经的CT和MRI影像特点.方法 观察健康成年男性的CT和MRI影像资料各10例、男性尸体骨盆标本MRI扫描影像5例.结果 直肠固有筋膜和骶前筋膜显示为环形直肠系膜后外侧的联合层;此联合层于S5椎体水平增厚为直肠骶骨筋膜.Denonvilliers筋膜是联合层在直肠系膜前面的延续.下腹下丛为联合层后外侧,联系直肠、膀胱和盆侧壁的网孔结构.直肠周围筋膜的MRI T2影像较T1和CT影像更清晰.结论 直肠固有筋膜和骶前筋膜在MRI T2影像中为连续、清晰的联合层,在指导直肠癌的影像学评估方面具有潜在的临床价值.%Objective To explore iconography of computed tomography( CT )and magnetic resonance imaging( MRI )of perirectal fasciae and autonomic nerves of healthy subjects. Methods CT and MRI images of 10 healthy male were collected. Five healthy male cadaveric pelvises underwent MRI examination. Images were reviewed. Results Rectal proper fascia and presacral fascia were combined single layer covering annular mesorectum from posterolateral aspect. The combined layer was bolded at the level of the fifth sacral vertebra that indicated rectosacral fascia. Denonvilliers fascia was continuation of the combined layer and covered the mesorectum from anterior aspect. Inferior hypogastric plexus was a mesh posterolateral to the combined layer and linked rectum and bladder to lateral wall of pelvis. Perirectal fasciae were observed more clearly on T2 weighed MRI images than on Tl images or CT images. Conclusion Rectal proper fascia and presacral fascia were continued and clear combined layer on T2 MRI images, which may play potential roles on iconographic evaluation of rectal caner. .

  14. Frequency of extrasystoles in healthy male employees.

    OpenAIRE

    Orth-Gomér, K; Hogstedt, C; Bodin, L; Söderholm, B

    1986-01-01

    To determine reference values for ectopic activity 147 actively employed healthy men aged from 15 to 65 years were examined by 24 hour Holter monitoring during their ordinary daily activities. Age was the only risk factor significantly associated with supraventricular and ventricular extrasystoles. During a six year follow up only two men died. In both the frequency of ventricular extrasystoles had been high, but neither of them died from cardiovascular disease. Because the distribution of th...

  15. Sustainable deposition for a healthy public and nature. Convention on Long-range Transboundary Air Pollution. Part 7; Duurzame depositie waarbij mens en natuur gezond blijven. Convention on Long-range Transboundary Air Pollution. Deel 7

    Energy Technology Data Exchange (ETDEWEB)

    Hettelingh, J.P.; Slootweg, J.; Posch, M. [Coordination Centre for Effects, MNP, Bilthoven (Netherlands)

    2007-07-01

    The CCE is the Data Center of the International Cooperative Programme on Modelling and Mapping of Critical Levels and Loads and Air Pollution Effects, Risks and Trends (ICP Modelling and Mapping, ICP M and M) and supports the work of the Convention on Long-range Transboundary Air Pollution (LRTAP) of the United Nations Economic Commission for Europe (UNECE). In this article attention is paid to the critical loads method, the related data and the European network. [Dutch] Kennis van duurzame depositieniveaus (critical loads) voor verzuring, vermesting en van zware metalen helpt bij de bepaling van bovengrenzen aan emissies. Dit is belangrijk voor de bescherming van Europese natuurgebieden en van de menselijke gezondheid. Critical loads worden berekend in ongeveer 1,3 miljoen vegetatie-bodem combinaties in Europa door een netwerk van 27 National Focal Centres in EC-lidstaten en Partijen onder de LRTAP Conventie (Convention on Long-range Transboundary Air Pollution). De spreiding en niveaus van critical loads worden bepaald door de aard van de beschouwde natuurlijke systemen, terwijl deposities afhankelijk zijn van landenemissies en menselijk handelen. De vergelijking van deposities met critical loads legt het verband tussen landenemissies en risico's voor natuur en mens. Om in het Europese luchtbeleid kosten en geografisch effectieve emissiereducties te helpen bepalen is kennis van robuuste critical loads dan ook zeer belangrijk. Hoe komen ze tot stand en welke rol spelen ze binnen de conventie? Hoe staat het met vermesting over vijftien jaar? En hoe verhoudt dit zich dat tot het broeikaseffect?.

  16. Variations in HDL-carried miR-223 and miR-135a concentrations after consumption of dietary trans fat are associated with changes in blood lipid and inflammatory markers in healthy men - an exploratory study.

    Science.gov (United States)

    Desgagné, Véronique; Guay, Simon-Pierre; Guérin, Renée; Corbin, François; Couture, Patrick; Lamarche, Benoit; Bouchard, Luigi

    2016-06-01

    A high consumption of trans fatty acids (TFAs) is associated with an increased risk of cardiovascular diseases (CVDs). High-density lipoproteins (HDLs) have many cardioprotective properties and transport functional microRNAs (miRNAs) to recipient cells. We hypothesized that dietary TFAs modify the HDL-carried miRNA profile, therefore modulating its cardioprotective properties. We assessed whether consumption of dietary TFAs modifies HDL-carried miR-223-3p and miR-135a-3p concentration and the inter-relationship between diet-induced changes in HDL-carried miRNA concentration and CVD risk markers. In a double blind, randomized, crossover, controlled study, 9 men were fed each of 3 experimental isoenergetic diets: 1) High in industrial TFA (iTFA; 3.7% energy); 2) High in TFA from ruminants (rTFA; 3.7% energy); 3) Low in TFA (control; 0.8% energy) for 4 weeks each. HDLs were isolated by ultracentrifugation and miRNAs were quantified by RT-qPCR. Variations in HDL-miR-223-3p concentration were negatively correlated with variations in HDL-cholesterol after the iTFA diet (rs = 0.82; P = 0.007), and positively correlated with variations in C-reactive protein concentration after the rTFA diet (rs = 0.75; P = 0.020). Variations in HDL-miR-135a-3p concentration were positively correlated with variations in total triglyceride (TG) concentration following the iTFA diet (rs = -0.82; P = 0.007), and with variations in low-density lipoprotein (LDL)-TG concentration following the rTFA diet (rs = 0.83; P = 0.005), compared to the control diet. However, the consumption of dietary TFAs has no significant unidirectional impact on HDL-carried miR-223-3p and miR-135a-3p concentrations. Our results suggest that the variability in the HDL-carried miRNAs response to TFA intake, by being associated with variations in CVD risk factors, might reflect physiological changes in HDL functions. PMID:27099924

  17. Men's Health: Violence Prevention

    Science.gov (United States)

    ... Men's Health This information in Spanish ( en español ) Violence prevention for men Get help for violence in ... whole community. Return to top Get help for violence in your life Are you a victim of ...

  18. Men and IC

    Science.gov (United States)

    ... Intimacy & IC Support for Men Children & IC La Cistitis Intersticial IC in Other Languages Associated Conditions Allergies and ... Intimacy & IC Support for Men Children & IC La Cistitis Intersticial IC in Other Languages Associated Conditions Allergies and ...

  19. Mental Health for Men

    Science.gov (United States)

    ... abuse Anxiety disorders and PTSD Body image and eating disorders Depression Sexual health for men Urinary health for men ... abuse Anxiety disorders and PTSD Body image and eating disorders Depression Other mental health conditions include bipolar disorder , schizophrenia , ...

  20. When Men Meet

    DEFF Research Database (Denmark)

    Bech, Henning

    men, mænd, masculinity, maskulinitet, gender, køn, homosexuality, homoseksualitet, modernity, modernitet, postmodernity, postmodernitet......men, mænd, masculinity, maskulinitet, gender, køn, homosexuality, homoseksualitet, modernity, modernitet, postmodernity, postmodernitet...

  1. Physical activity and television watching in relation to semen quality in young men

    DEFF Research Database (Denmark)

    Gaskins, Audrey Jane; Mendiola, Jaime; Afeiche, Myriam;

    2015-01-01

    ) watching with sperm parameters in a population of young, healthy men. METHODS: Men aged 18-22 years (n=189) from the Rochester Young Men's Study (2009-2010) participated in this analysis. Physical activity (h/week of moderate and vigorous exercise) and TV watching (h/week of TV, video or DVD watching) over...

  2. 生活方式因素健康分值与男性癌症发病的公共卫生学评价%Lifestyle-related factors and cancer incidence in men: a public health assessment based on a 'healthy lifestyle score'

    Institute of Scientific and Technical Information of China (English)

    唐认桥; 郑苇; 李泓澜; 舒晓鸥; 项永兵

    2013-01-01

    目的 探讨生活方式因素及健康分值对上海市成年男性恶性肿瘤发病的影响.方法 利用2002-2006年上海市男性健康队列(SMHS)的基线调查资料,至2009年12月最近一次随访,男性队列累积收集恶性肿瘤新病例2033例.根据吸炯(吸烟计0分,不吸烟计1分)、饮酒(≥1 drinks/d计0分,<1drinks/d计1分)、BMI(<18.5 kg/m2或≥28 kg/m2计0分,18.5~27.9 kg/m2计1分)、体力活动(<54 Met-hours/week计0分,≥54 Met-hours/week计1分)、蔬菜水果摄入(<451g/d计0分,≥451 g/d计1分)五种常见生活方式因素建立健康生活方式分值表,分值分布范围为0(最不健康生活方式)至5(最健康生活方式)分.采用Cox回归模型估计健康生活方式分值与癌症的相对危险度(HR)及其95%CI.结果 相对于得分为0或者1分的人群组,得分为2~5分人群组发生癌症的HR值分别为0.77(95%CI:0.66 ~ 0.90)、0.67(95%CI:0.58 ~ 0.78)、0.56(95%CI:0.47 ~ 0.65)、0.51(95%CI:0.42 ~ 0.62).健康生活方式得分少于3项的人群癌症发病归因危险度百分比(PAR%)为10.4%(95%CI:7.3% ~ 13.5%).结论 不吸烟、不过量饮酒,保持正常体型,适当体育锻炼及多食蔬菜水果可较显著降低癌症的发生,保持健康的生活方式具有显著的公共卫生学效益.%Objective To evaluate the effects of combined lifestyle-related factors and risk of cancer incidence among adult men in urban Shanghai.Methods Information was obtained from 60 817 men in the Shanghai Men' s Health Study (2002-2006) program and 2033 incident cancers who were confirmed at the end of 2009.A healthy lifestyle score (HLS) system was developed,based on five lifestyle-related factors,and participants were scored one point for each of the healthy behaviour:never smoked,alcohol intake less than 1 drink/day,under normal weight range (18.5-27.9 kg/m2),physical activity (≥ 54 Met-hours/week),fruit and vegetable intake ≥451 g/day,the else would

  3. Effects of Sleep Deprivation at Different Time During Night on Serumcortisol and Cognition Function of Healthy Men%不同时间睡眠剥夺对健康男性血清皮质醇及认知功能的影响

    Institute of Scientific and Technical Information of China (English)

    孙平; 殷军波; 高安民

    2013-01-01

      目的研究部分睡眠剥夺对健康男性血清皮质醇及认知功能的影响。方法采用交叉设计的自身对照性试验研究,14例健康男性先进入上半夜睡眠剥夺,经过7d睡眠洗脱期,进入下半夜睡眠剥夺,每个睡眠剥夺包括7d。每个睡眠剥夺晨起7:00时抽取空腹血测定血清皮质醇,每日12:00时行快速敲击键盘任务,单词记忆和单词识别测试。结果睡眠剥夺均导致皮质醇的下降,剥夺下半夜睡眠比上半夜更明显,恢复睡眠后,皮质醇恢复到未剥夺前的状态,睡眠剥夺均导致记忆、操作能力和注意力的下降,剥夺上半夜睡眠表现更为明显。结论睡眠剥夺对机体的认知功能和血清皮质醇的分泌存在明显影响。%Objective To investigate the effects of short-term sleep deprivation(SD)at different time during night on serum cortisol level and cognition function of healthy men .Methods Crossover design their own controlled trial was used,14 healthy men were first to enter the late-sleep deprivation,after a washout period of seven days of sleep into the midnight sleep deprivation,each sleep deprivation include 7 days.Early morning 7:00 fasting blood serum cortisol was collected after each sleep deprivation.The daily 12:00 line quick keystrokes task,word memory and word recognition test were taken.Results The cortisol levels lowered after 2 types of SD,and more obviously of deprivation the midnight sleep than the late-sleep,Cortisol recover to the state of not deprive after sleep recovery .Sleep deprivation lead to a de-cline in memory,operating capacity and attention,deprive midnight sleep became more evident .Conclusion Sleep dep-rivation significantly affect the body cognitive function and serum cortisol secretion .

  4. Rundt om Mad Men

    DEFF Research Database (Denmark)

    Nielsen, Jakob Isak

    2011-01-01

    Artiklen gør rede for Mad Mens tilblivelse, dens populærkulturelle efterdønninger, multimediale forgreninger og værkæstetiske karakteristika. "Story Matters Here" lyder AMCs motto, men Mad Men tilbyder et bredspektret engagement, der går langt ud over at følge med i en vedkommende fortælling...

  5. Aneuploidy in spermatozoa in infertile men

    Directory of Open Access Journals (Sweden)

    Grabar V.V.

    2014-09-01

    Full Text Available Background. An important problem is to investigate the frequency of aneuploidy in sperms of infertile men according to their changes in karyotype, that would allow to understand the contribution of paternal factor in the formation of chromosomal aberrations of embryos. Objective. To study the frequency of aneuploidy in spermatozoa from infertile men with normal karyotype and chromosomal changes. Methods. Fluorescence in situ hybridization (FISH of spermatozoa (chromosomes 13, 16, 18, 21, 22, X and Y was performed in 79 infertile men with normal karyotype, in 16 with chromosomal abnormalities, in 18 with chromosomal polymorphism and in 29 healthy men. In total 23,867 of sperm cores were analyzed. Results. In men with infertility an aneuploid sperms were in 5.7 times more often than in fertile patients (P˂0,01. An aneuploidy of sperms in infertile men with a chromosomal abnormality were in 2.1 times, with a chromosomal polymorphism in 1.4 times more often than in infertile patients with a normal karyotype (P˂0,05. In all patients the most common aneuploidies were in chromosomes XY, 21 and 22. The study of aneuploidy frequency in spermatozoa at different variants of chromosomal pathology showed that in men with paracentric inversions rate was 5.75 - 7.65%, whereas in patients with quantitative and other structural chromosomal abnormalities it was above 11.73 - 17.82%. Conclusion. The frequency of chromosomal aberrations in spermatozoa is highest in men with genomic and chromosomal mutations. In infertile patients with changes in the karyotype the gametes with mutations de novo can be produced. Citation: Grabar VV, Feskov AM, Stefanovich AV, Zhilkova ES. [Aneuploidy in spermatozoa in infertile men]. Morpho-logia. 2014;8(3:7-12. Russian.

  6. Men in Feminised Workplaces

    DEFF Research Database (Denmark)

    Warming, Kenn

    »Male nurses – Is that really what It’s called?« »Aren’t all male hairdressers gay?« »All preschool educators do is to wipe children’s bums, isn’t it?« »Cleaning is a job for women, not for menMen working in women’s professions often give rise to a lot of prejudices. But why? Are these men les...

  7. Regional differences in healthy life expectancy in the Netherlands.

    OpenAIRE

    Groenewegen, Peter P; Westert, Gert P; Boshuizen, Hendriek C.

    2003-01-01

    Background. Healthy life expectancy has mainly been studied at the level of healthcare systems rather than at regional level within healthcare systems. In this article, healthy life expectancy at birth and at 65 years of age for men and women in the Netherlands has been described, and factors related to these regional variations have been explored. Methods. Ecological study of 27 healthcare regions (hospital catchment areas). Life expectancy and healthy life expectancy were calculated using 1...

  8. Healthy Family 2009: Assuring Healthy Aging

    Science.gov (United States)

    ... Navigation Bar Home Current Issue Past Issues Healthy Family 2009 Assuring Healthy Aging Past Issues / Winter 2009 ... for steady, modest loss. Seek emotional support from family and friends. Expect setbacks; forgive yourself. Make physical ...

  9. Healthy Family 2009: Assuring Healthy Aging

    Science.gov (United States)

    ... Issue Past Issues Healthy Family 2009 Assuring Healthy Aging Past Issues / Winter 2009 Table of Contents For ... please turn Javascript on. 7 Smart Steps to Aging Well 1. Control Blood Pressure You can have ...

  10. Getting on Track: Physical Activity and Healthy Eating for Men

    Science.gov (United States)

    ... Research Training & Career Development Grant programs for students, postdocs, and faculty Research at NIDDK Labs, faculty, and ... beer has 160 calories. [ Top ] Keeping Portions Under Control Pay attention to the serving sizes listed on ...

  11. Betaine supplementation lowers plasma homocysteine in healthy men and women

    NARCIS (Netherlands)

    Steenge, G.R.; Verhoef, P.; Katan, M.B.

    2003-01-01

    Elevated levels of plasma total homocysteine are associated with a higher risk of cardiovascular disease. Betaine and 5-methyltetrahydrofolate can remethylate homocysteine into methionine via independent reactions. We determined the effect of daily betaine supplementation, compared with both folic a

  12. Getting on Track: Physical Activity and Healthy Eating for Men

    Science.gov (United States)

    ... cheese = 4 stacked dice 1/2 cup of ice cream = 1/2 baseball 2 tablespoons of peanut butter = ... for Scientists Current Funding Opportunities Funded Grants & Grant History Funding Process Research Programs & Contacts Research Training & Career ...

  13. Healthy Sleep Habits

    Science.gov (United States)

    ... Sleep Apnea Testing CPAP Healthy Sleep Habits Healthy Sleep Habits Your behaviors can have a major impact ... team at an AASM accredited sleep center. Quick Sleep Tips Follow these tips to establish healthy sleep ...

  14. Keeping Your Voice Healthy

    Science.gov (United States)

    ... Find an ENT Doctor Near You Keeping Your Voice Healthy Keeping Your Voice Healthy Patient Health Information ... heavily voice-related. Key Steps for Keeping Your Voice Healthy Drink plenty of water. Moisture is good ...

  15. Men in Feminised Workplaces

    DEFF Research Database (Denmark)

    Warming, Kenn

    masculine than other men? Or do they rather represent a new, more tolerant and less stereotypical male gender role? If less restricted by stereotypes, are men then eager to challenge traditional dichotomised perceptions of man/masculinity and woman/femininity? By means of analyses of interviews with more...

  16. Men's Entrance to Parenthood

    Science.gov (United States)

    Fein, Robert A.

    1976-01-01

    Men (N=30) attending childbirth preparation classes were interviewed before and after the birth of a first child. The data suggest that developing some kind of coherent role was more important to men's adjustments to postpartum family life than developing any particular role of high or low home life sharing activity. (Author)

  17. Eating disorders in men.

    Science.gov (United States)

    Cottrell, Damon B; Williams, Jeffrey

    2016-09-22

    Eating disorders are traditionally thought of as a problem specific to women, but evidence suggests the disorders also occur in men. Identifying the problem and referring patients for treatment can be difficult. Understanding the nuances of these disorders and realizing the incidence in men is important, as it is often overlooked as a differential diagnosis. PMID:27552690

  18. What Do Men Want?

    Science.gov (United States)

    Kimmel, Michael S.

    1993-01-01

    Definitions of the male role are changing as more men seek fulfillment in family life, redefine success, or attempt to balance family and career. Corporate structure no longer fits the lives of many men, but employers continue to resist change. (SK)

  19. Bellagio Report on Healthy Agriculture, Healthy Nutrition, Healthy People

    OpenAIRE

    Ole Faergeman; Artemis P. Simopoulos; Peter G. Bourne

    2013-01-01

    The Bellagio Report on Healthy Agriculture, Healthy Nutrition, Healthy People is the result of the meeting held at the Rockefeller Foundation Bellagio Center in Lake Como, Italy, 29 October–2 November 2012. The meeting was science-based but policy-oriented. The role and amount of healthy and unhealthy fats, with attention to the relative content of omega-3 and omega-6 fatty acids, sugar, and particularly fructose in foods that may underlie the epidemics of non-communicable diseases (NCD’s) wo...

  20. [Eating disorders in men].

    Science.gov (United States)

    Bak, Daniel

    2008-01-01

    Despite of being perceived as 'woman's diseases', eating disorders were described among boys and adult men. This article presents epidemiological data on anorexia nervosa, bulimia nervosa and binge eating disorder in men. The clinical presentation of eating disorders in men was described and compared with similar data from the female population. Moreover, a significance of selected risk factors, specifically those referring to men, was discussed. These are: the disturbance of body perception, personality traits and potential association of eating disorders with sexual orientation. Efficacy of different psychotherapy approaches aimed at eating disorders was summarized. Rules governing psychotherapy of men suffering from eating disorders were described. Specific features of eating disorders' aetiology were taken into account together with characteristic difficulties influencing treatment. PMID:19697523

  1. High prevalence of osteoporosis in Saudi men

    International Nuclear Information System (INIS)

    Objective was to determine the prevalence of osteoporosis in healthy Saudi men. We randomly recruited 429 Saudi men from the community. The recruited Saudi men were subjected to an interview to reveal their lifestyle parameters, calcium intake and level of activity. Bone densitometry was assessed at lumbar spine (L-4) and the femoral neck. The dual x-ray absorptiometry (DXA) scan was carried out in the Nuclear Medicine at King Khalid University Hospital, Riyadh, Saudi Arabia from September 2002 to December 2004. The World Health Organization definition of low bone mineral density was used. Poor oral calcium intake and low level of daily activity were noted. The overall prevalence of osteopenia for the lumbar spine in the whole group was 35.7% while osteoporosis was present in 21.4% of the subjects. In the femoral neck, osteopenia was noted in 38% and osteoporosis in 11.4%. When either lumbar spine or femoral neck osteoporosis is used for diagnosis, the prevalence of osteoporosis rises to 23.5%. Within the whole group, osteopenia and osteoporosis were more common in individuals above the age of 50 than those below 50 years old. Low bone mineral density occurs with high frequency in Saudi men. Lumbar spine appears to be affected to a higher degree. The reason for the high prevalence of osteoporosis in Saudi men is unclear. Possible underlying causes include nutritional, life style and genetic factors. (author)

  2. Famous Space Men's Salon Beijing's professional salon chain for men

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Services: Professional deep treatment of men's laces Treating men's "heer bellies" Spa hydrotherapy Brand-new French Darphin top-class aromatherapy Spa herbal massage Treatment for men's reproductive health

  3. Famous Space Men's Salon Beijing's professional salon chain for men

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Services: Professional deep treatment of men's faces Treating men's "beer bellies" Spa hydrotherapy Brand new French Darphin top-class aromatherapy Spa herbal massage Treatment for men's reproductive health

  4. Health screening - men age 65 and older

    Science.gov (United States)

    Health maintenance visit - men - over age 65; Physical exam - men - over age 65; Yearly exam - men - over age 65; Checkup - men - over age 65; Men's health - over age 65; Preventive care exam - men - over ...

  5. Healthy Option Preferences of Rural Restaurant Customers

    Science.gov (United States)

    Nothwehr, Faryle; Snetselaar, Linda; Dawson, Jeffrey D.; Hradek, Christine; Sepulveda, Marisol

    2009-01-01

    In preparation for an intervention study in three rural Iowa restaurants, 250 customers were surveyed regarding their interest in dietary change, perceptions of the restaurant, and interest in healthy options. Customers were ages 18 to 88, with a mean age of 52, and 53% were women. Most agreed that the restaurant offers healthy meals. Options customers stated they were most likely to order if available included meat that is baked or broiled, whole-wheat bread, fresh fruit or steamed vegetables, and regular salad dressing on the side. They were least interested in low-fat sour cream, low-fat salad dressing, low-fat milk, low-calorie dessert, and holding high-fat ingredients. Women were more likely to indicate interest in healthy options than were men. Interest in several options was also positively associated with age. Increasing the healthy options in restaurants may be especially effective in changing the dietary intake of women and older adults. PMID:19515859

  6. Multiple endocrine neoplasia (MEN) I

    Science.gov (United States)

    Wermer syndrome; MEN I ... MEN I is caused by a defect in a gene that carries the code for a protein called menin. ... care provider if you notice symptoms of MEN I or have a family history of this condition.

  7. Men's Health and Spina Bifida

    Science.gov (United States)

    ... many men in general), most still have normal sexual desire. The good news is that ED is a ... sexually transmitted infections? Men with SB have normal sexual desires like all men. Similarly, sexually transmitted infections (STIs), ...

  8. Antisperm protein targets in azoospermia men

    Directory of Open Access Journals (Sweden)

    Mohammad-Sadegh Soltani Zangbar

    2016-01-01

    Full Text Available BACKGROUND: The number of couples that meet the definition of infertility at reproductive ages is increasing worldwide. One of the most known conditions of infertility in males is azoospermia, defined as complete absence of spermatozoa in the semen. Azoospermia manifests in two forms, namely obstructive and non-obstructive azoospermia. Although the presence of antisperm antibody (ASA has been reported in 88% of the patients with obstructive azoospermia (OA, interestingly, there is no data regarding ASA targets in OA individuals. AIM: The present study aimed to identify sperm antibody targets in a group of OA men. SETTINGS AND DESIGN: The present study was carried out on 27 OA infertile men and 27 healthy fertile age-matched males as cases and controls, respectively. SUBJECTS AND METHODS: The sperm proteome was separated using two-dimensional gel electrophoresis technique, transferred onto the polyvinylidene fluoride membrane, and blotted with the sera of a group of OA men. Then, it was compared with the membranes blotted with the sera of a group of healthy fertile men. Matrix-assisted laser desorption/ionization time-of-flight/time-of-flight (MALDI TOF/TOF mass spectrometry was used to identify the different blotted spots and finally the results of the mass analysis were confirmed using reverse transcriptase polymerase chain reaction method. RESULTS: The results indicated that OA patients might produce antibody against two sperm proteins, Tektin-2 and triose phosphate isomerase. Moreover, the expressions of the two targeted proteins were confirmed at RNA level. CONCLUSIONS: The findings of the present study revealed two functionally important sperm proteins as antibody targets in azoospermic men.

  9. Men on Parental Leave

    OpenAIRE

    Trutnovská, Aneta

    2014-01-01

    The aim of this thesis is based on the scientific literature related to the topic, and interviews with specific men on parental leave to point out, in particular, on the grounds that affect men, to the decision to become a full-time father, find out how these families work, and also to point out responses or opinions around which these men often encounter. The theoretical part is devoted to male parental leave in terms of its relation to the children, the themes taking on parental leave, the ...

  10. Heart Healthy Eating

    Science.gov (United States)

    ... disease fact sheet Heart health and stroke Heart-healthy eating Heart-healthy eating is an important way to lower your risk ... and unhealthy fats. Expand All Why is heart-healthy eating important? Heart-healthy eating, along with regular exercise ...

  11. HPV and Men

    Science.gov (United States)

    ... Twitter STD on Facebook Sexually Transmitted Diseases (STDs) HPV and Men - Fact Sheet Language: English Español (Spanish) ... all sexually active people will get human papillomavirus (HPV) at some time in their life. Although most ...

  12. Men and Depression

    Science.gov (United States)

    ... in crisis? For more information Share Men and Depression Download PDF Download ePub Order a free hardcopy ... If so, you may have depression. What is depression? Everyone feels sad or irritable sometimes, or has ...

  13. Interactions among age, adiposity, bodyweight, lifestyle factors and sex steroid hormones in healthy Singaporean Chinese men%健康新加坡华裔男性年龄、肥胖症、体重、生活方式要素和性类固醇激素的相互作用

    Institute of Scientific and Technical Information of China (English)

    V. H. H. Goh; T. Y. Y. Tong; H.P.P. Mok; B.Said

    2007-01-01

    Aim: To examine the inter-relationships among age, lifestyle factors, anthropometric parameters, percent body fat and steroid hormone parameters in 531 healthy Singaporean Chinese men aged between 29 and 72 years old. Methods:Various lifestyle parameters were quantified through a survey, and testosterone (T), estradiol (E2), dehydroepiandrosterone sulphate (DHEAS) and sex hormone binding globulin (SHBG) were measured using established methods.Anthropometric parameters were collected and computed, and percent body fat (Siri) was measured using the DEXA scanner. Results: SHBG, DHEAS, bioavailable-T (Bio-T), E2, Siri, Ht, W/H, W/Ht and work stress were independently correlated with age. Using multivariate analyses and adjusting for age and other related factors, exercise,smoking and alcohol consumption have positive impacts on androgen levels and body composition. However, black and green tea consumption was associated with negative effects on body composition and with higher levels of E2 and Free Estradiol Index (FEI). Men with shorter sleep duration had significantly lower T levels as compared to those with 6 h or more of nightly sleep. Higher T levels were associated with lower levels of adiposity and other indices of adiposity, whereas higher E2 levels were related to higher levels of adiposity. Men with higher DHEAS were significantly taller and heavier than those with low DHEAS levels. Conclusion: The study showed the close interactions among the gonadal/adrenal and metabolic compartments, with age being a key determinant in their interactions.Lifestyle factors such as exercise, smoking, sleeping and alcohol and tea consumption might play significantly roles in determining the status of health in men. (Asian JAndrol 2007 Sep; 9: 611-621)%目的:检测在531个年龄在29到72岁之间的健康新加坡华裔男性的年龄、生活方式要素、人体测量参数、体脂含量和类固醇激素参数的相互关系.方法:用调查量化各种生活

  14. HPV Infection in Men

    Directory of Open Access Journals (Sweden)

    Joel M. Palefsky

    2007-01-01

    Full Text Available While much is known about the natural history of cervical human papillomavirus (HPV infection and its consequences, including cervical intraepithelial neoplasia and cervical cancer, relatively little is known about the natural history of anogenital HPV infection and diseases in men. In part this reflects difficulties in penile sampling and visual assessment of penile lesions. Anal HPV infection and disease also remain poorly understood. Although HPV is transmitted sexually and infects the genitals of both sexes, the cervix remains biologically more vulnerable to malignant transformation than does the penis or anus in men. An understanding of male HPV infection is therefore important in terms of reducing transmission of HPV to women and improving women's health. However, it is also important due to the burden of disease in men, who may develop both penile and anal cancer, particularly among HIV-positive men who have sex with men. Improved sampling techniques of the male genitalia and cohort studies in progress should provide important information on the natural history of anogenital HPV infection and disease in men, including risk factors for HPV acquisition and transmission. The impact of HPV vaccination in women on male anogenital HPV infection will also need to be assessed.

  15. Health Information Needs of Men

    Science.gov (United States)

    Robinson, Mark; Robertson, Steve

    2014-01-01

    Objective: To understand the views of men and service providers concerning the health information needs of men. Design: A men's health programme was implemented aimed at developing new health information resources designed for use by local organizations with men in socially disadvantaged groups. Research was carried out at the scoping stage…

  16. Aging and masculinity: portrayals in men's magazines.

    Science.gov (United States)

    Hurd Clarke, Laura; Bennett, Erica V; Liu, Chris

    2014-12-01

    Textual and visual representations of age are instructive as they suggest ideals towards which individuals should strive and influence how we perceive age. The purpose of our study was to investigate textual and visual representations of later life in the advertisements and interest stories of six widely read North American male-oriented magazines (namely, Esquire, GQ, Maxim, Men's Health, Men's Journal, and Zoomer). Through a content analysis and a visual textual analysis, we examined how older men were depicted in the magazine images and accompanying texts. Our findings revealed that older men were largely absent, and when portrayed, were positively depicted as experienced and powerful celebrities or as healthy and happy unknown individuals. The magazine advertisements and interest stories collectively required individuals to engage in consumer culture in order to achieve age and masculinity ideals and stave off the transition from the Third Age to the Fourth Age. We consider our findings in relation to theorizing about ageism, age relations, the Third and Fourth Ages, and idealized aging masculinity. PMID:25456619

  17. Sexual dysfunctions in men treated for testicular cancer

    DEFF Research Database (Denmark)

    Rosendal, Susanne; Kristensen, Ellids; Giraldi, Annamaria G E

    2008-01-01

    Patients treated for testicular cancer have increased risk of ejaculatory, orgasmic and erectile dysfunction compared with healthy men. The underlying relations are unclear. This review describes sexual dysfunctions that are associated with various treatment modalities. One meta-analysis and 11...... understanding sexual dysfunctions in patients with testicular cancer....

  18. Nocturnal variations in lower-leg subcutaneous blood flow in paraplegic men

    DEFF Research Database (Denmark)

    Sindrup, J H; Wroblewski, H; Kastrup, J;

    1992-01-01

    1. Lower-leg subcutaneous adipose tissue blood flow rates were measured over 12-20 h under ambulatory conditions by means of the 133Xe-washout technique in nine paraplegic men, all with complete spinal cord lesions at or below the Th 6 level, and in nine age-matched healthy men. Portable CdTe...

  19. Anabolic hormone profiles in elite military men.

    Science.gov (United States)

    Taylor, Marcus K; Kviatkovsky, Shiloah A; Hernández, Lisa M; Sargent, Paul; Segal, Sabrina; Granger, Douglas A

    2016-06-01

    We recently characterized the awakening responses and daily profiles of the catabolic stress hormone cortisol in elite military men. Anabolic hormones follow a similar daily pattern and may counteract the catabolic effects of cortisol. This companion report is the first to characterize daily profiles of anabolic hormones dehydroepiandrosterone (DHEA) and testosterone in this population. Overall, the men in this study displayed anabolic hormone profiles comparable to that of healthy, athletic populations. Consistent with the cortisol findings in our prior report, summary parameters of magnitude (hormone output) within the first hour after awakening displayed superior stability versus summary parameters of pattern for both DHEA (r range: 0.77-0.82) and testosterone (r range: 0.62-0.69). Summary parameters of evening function were stable for the two hormones (both panabolic balance and resultant effects upon health and human performance in this highly resilient yet chronically stressed population. PMID:27083310

  20. Working through resistance in engaging boys and men towards gender equality and progressive masculinities

    OpenAIRE

    Ratele, Kopano

    2015-01-01

    Over the last two decades, a focus on challenging and transforming dominant forms of masculinity and engaging boys and men towards gender equality and healthy masculinities has permeated South African social and health sciences and the humanities. This focus on men and boys has also been evident in intervention and activist work. However, the turn to boys, men and masculinities has not gone without resistance, contestation and contradictions. A range of localised and global realities has frus...

  1. Health screening - men - ages 18 to 39

    Science.gov (United States)

    Health maintenance visit - men - ages 18 to 39; Physical exam - men - ages 18 to 39; Yearly exam - ... 39; Checkup - men - ages 18 to 39; Men's health - ages 18 to 39; Preventive care exam - men - ...

  2. Health screening - men - ages 40 to 64

    Science.gov (United States)

    Health maintenance visit - men - ages 40 to 64; Physical exam - men - ages 40 to 64; Yearly exam - ... 64; Checkup - men - ages 40 to 64; Men's health - ages 40 to 64; Preventive care - men - ages ...

  3. Do single women value early retirement more than single men?

    DEFF Research Database (Denmark)

    Danø, Anne Møller; Ejrnæs, Mette; Husted, Leif

    2005-01-01

    and health are important determinants of the retirement decision. Furthermore, we find substantial gender differences in the retirement pattern. Healthy single women value retirement more than healthy single men and are willing to reduce their disposable income to 74% of their previous income while......The focus of this paper is to analyse why a large fraction of single elderly people choose to retire early. A structural model directly based on the individual decision of labour supply is estimated on a sample of singles, where singles are defined as those who are living alone. We find that income...... men are willing to reduce the income to 81%. Men's retirement decision is mainly influenced by income and health, whereas women's retirement decision is also affected by education and unemployment experience...

  4. Aging men-Challenges ahead

    Institute of Scientific and Technical Information of China (English)

    Bruno Lunenfeld

    2001-01-01

    The prolongation of life expectancy and the drastic reduction of fertility rate are the primary cause of an aging world. It is projected that the elderly (above 65) will increase within the next 25 years by 82 %, whereas the new born only by 3 %. Despite the enormous medical progress during the past few decades, the last years of life are still accompanied by increasing ill health and disability. The ability to maintain active and independent living for as long as possible is a crucial factor for aging in health and dignity. Therefore, the promotion of healthy aging and the prevention of disability in men, must assume a central role in medical research and medical practice as well as in the formulation of national health and social policies. Effective programs promoting health and aging will ensure a more efficient use of health and social services and improve the quality of life in older persons by enabling them to remain independent and productive. The most important and drastic gender differences in aging are related to organs and or systems dependant or influenced by reproductive hormones. In distinction to the course of reproductive aging in women, with the rapid decline in sex hormones and expressed by the cessation of menses, aging men experience a slow and continuous decline of hormones. This decline in endocrine function involves: A decrease of testosterone, dehydroepiandrosterone (DHEA),oestrogens, thyroid stimulating hormone (TSH), growth hormone (GH), insulin-like growth factor-1 (IGF-1), and melatonin. This decrease is concomitant with an increase of LH and FSH. In addition sex hormone binding globulin's (SHBG) increase with age resulting in further lowering the concentrations of free biologically active androgens. Interventions such as hormone replacement therapy may prevent, delay or alleviate the debilitating conditions which may result from secondary partial endocrine deficiency. Primary and secondary preventive strategies such as the promotion of

  5. Healthy Air Outdoors

    Science.gov (United States)

    ... lung.org > Our Initiatives > Healthy Air > Outdoor Healthy Air Outdoors The quality of the air we breathe ... families and can even shorten their lives. Outdoor Air Pollution and Health Outdoor air pollution continues to ...

  6. Healthy Aging -- Sexual Health

    Science.gov (United States)

    ... address Submit Home > Healthy Aging > Sexual health Healthy Aging This information in Spanish ( en español ) Sexual health ... to discuss with your doctor. Sexual Health and Aging: Keep the Passion Alive (Copyright © Mayo Foundation) - This ...

  7. Tips for Healthy Eating

    Science.gov (United States)

    ... Current Issue Past Issues Health Lines for Pregnancy …healthy eating, exercising, and 10 more handy sources of information ... please turn Javascript on. Photo: iStock Tips for Healthy Eating To meet your body's needs and help avoid ...

  8. Old men living alone

    DEFF Research Database (Denmark)

    Hansen, Kristian Frausing; Munk, Karen Pallesgaard

    2014-01-01

    Background: Even in the Danish welfare state inequality in health proves hard to overcome. According to the literature elderly men living alone seem to be a vulnerable group in several respects: they lead shorter lives; are at increased risk of committing suicide; and some are found to have....... 1. An electronic survey is distributed nationwide to municipal preventive home visitors in order to obtain information about their views on the men’s particular needs and the suitability of current health care services. 2. A group of elderly men living alone is interviewed about their own opinions...... and views on the matters. Results: It is expected that the study will contribute to a nuanced basis of knowledge for the public health care services for elderly men living alone. Also importantly, we wish to focus health care professionals’ attention to the question of realistic and meaningful goals...

  9. Healthy,Happy trees

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Healthy trees are important to us all. Trees provide shade, beauty, and homes for wildlife. Trees give us products like paper and wood. Trees can give us all this only if they are healthy.They must be well cared for to remain healthy.

  10. Healthy Drinks for Kids

    Science.gov (United States)

    ... Smoothie Pregnant? Your Baby's Growth Healthy Drinks for Kids KidsHealth > For Parents > Healthy Drinks for Kids Print A A A Text Size What's in ... población infantil We know it's important to get kids to eat healthy foods, but what about getting ...

  11. Decline of Functional Capacity in Healthy Aging Workers

    OpenAIRE

    Soer, Remko; Brouwer, Sandra; Geertzen, Jan H.; van der Schans, Cees P.; Groothoff, Johan W; Reneman, Michiel F.

    2012-01-01

    Soer R, Brouwer S, Geertzen JH, van der Schans CP, Groothoff JW, Reneman MF. Decline of functional capacity in healthy aging workers. Arch Phys Med Rehabil 2012;93:2326-32. Objectives: (1) To study the natural decline in functional capacity (FC) of healthy aging workers; (2) to compare FC to categories of workload; and (3) to study the differences in decline between men and women. Design: Cross-sectional design. Setting: A rehabilitation center at a university medical center. Participants: Vo...

  12. Moderators of noise-induced cognitive change in healthy adults

    OpenAIRE

    Bernice AL Wright; Peters, Emmanuelle R.; Ulrich Ettinger; Elizabeth Kuipers; Veena Kumari

    2016-01-01

    Environmental noise causes cognitive impairment, particularly in executive function and episodic memory domains, in healthy populations. However, the possible moderating influences on this relationship are less clear. This study assessed 54 healthy participants (24 men) on a cognitive battery (measuring psychomotor speed, attention, executive function, working memory, and verbal learning and memory) under three (quiet, urban, and social) noise conditions. IQ, subjective noise sensitivity, sle...

  13. Breast cancer in men

    Science.gov (United States)

    ... in situ-male; Intraductal carcinoma-male; Inflammatory breast cancer-male; Paget disease of the nipple-male; Breast cancer-male ... The cause of breast cancer is not clear. But there are risk ... breast cancer more likely in men: Exposure to radiation Higher ...

  14. Syphilis and MSM (Men Who Have Sex with Men)

    Science.gov (United States)

    ... Twitter STD on Facebook Sexually Transmitted Diseases (STDs) Syphilis & MSM (Men Who Have Sex With Men) - CDC ... Share Compartir Once nearly eliminated in the U.S., syphilis is increasing, especially among gay, bisexual, and other ...

  15. Action plan for healthy agriculture, healthy nutrition, healthy people

    Directory of Open Access Journals (Sweden)

    Artemis P. Simopoulos

    2013-04-01

    Full Text Available In October 2010, the World Council on Genetics, Nutrition and Fitness for Health promoted a scientific meeting in Ancient Olympia, Greece, on the theme Healthy Agriculture, Healthy Nutrition, Healthy People. The meeting focused on evolutionary aspects of human diet through the life cycle in terms of genetic predisposition, overall health, prevention of disease and of unhealthy behaviors, such as poor physical activity, and dietary changes caused by the introduction of modern agriculture, from the Agribusiness to systems of food production, from climate changes to the needs imposed by urban agriculture and architecture. Nutritional medical (mostly cardiological and political aspects of disease prevention through healthy dietary habits and physical activity have always been seen in isolation. The meeting, the first of its kind, treated such aspects together, recognizing the importance of integrating and initiating a dialogue between these disciplines. The meeting gathered together experts in cardiovascular prevention, nutrition, as well as politicians, for a global discussion of these themes. A summary statement was then compiled, focusing on the main themes on which a consensus had been reached. I strongly believe that such themes have great relevance for public health, raising the need for disseminating them as widely as possible. I am thankful to the Editor of the Italian Journal of Medicine for allowing this summary document to be made available for the first time in Italy.Raffaele De Caterina

  16. Early maladaptive schemas and sexual dysfunction in men.

    Science.gov (United States)

    Quinta Gomes, Ana Luísa; Nobre, Pedro

    2012-02-01

    The objective of the present study was to investigate the role played by early maladaptive schemas (EMS) on male sexual functioning and clarify the way these nuclear cognitive structures discriminate men with and without sexual dysfunction. A total of 242 men participated in the study (a community sample of 200 men and a clinical sample of 42 men with a DSM-IV diagnosis of sexual dysfunction). The community sample was divided into a control group (n=147) and a sub-clinical group (n=53), according to the cutoff scores of the International Index of Erectile Dysfunction (Rosen et al., 1997). All participants completed a set of measures assessing EMS (Young & Brown, 1989), sexual functioning (Rosen et al., 1997), psychopathology (Derogatis & Spencer, 1982), and cognitive schemas activated in hypothetical unsuccessful sexual situations (Nobre & Pinto-Gouveia, 2009a). Findings supported the hypothesis of a typical cognitive pattern in men with sexual difficulties. After controlling for psychopathology, men with sexual dysfunction reported more dependence/incompetence EMS and activated more difference, helpless, and particularly incompetence schemas in hypothetical unsuccessful sexual situations, in comparison to sexually healthy men. These results have important therapeutic implications for sex therapy. PMID:21975922

  17. Men's health issues in Asia.

    Science.gov (United States)

    Ho, Christopher C K; Tan, Hui Meng

    2013-09-01

    Men's health has gained prominence over the past few years but it is still not on par with the attention or funding that women and child health is getting. In Asia, this issue is even more conspicuous. With westernization of lifestyle, Asian men's problems emulate their Western counterparts but there are certain issues unique to Asian men due to cultural differences. This review will discuss the health issues affecting Asian men and suggest measures that can be taken to overcome them. PMID:23822757

  18. Have a Healthy Heart (A Minute of Health with CDC)

    Centers for Disease Control (CDC) Podcasts

    2015-02-05

    Heart disease continues to be the leading cause of death for both men and women in the U.S. This podcast discusses the importance of decreasing the chances of developing heart disease via a healthy lifestyle.  Created: 2/5/2015 by MMWR.   Date Released: 2/5/2015.

  19. Electroretinography in healthy subjects in relation to systemic glucocorticoid intake

    DEFF Research Database (Denmark)

    Kappelgaard, Per; Hansen, Katrine B; Vilsbøll, Tina;

    2012-01-01

    -specified level of clamped hyperglycemia. The study included 10 eyes in 10 healthy lean men aged 25 ± 3 years (mean ± SD). The subjects were examined before and after oral intake of prednisolone 37.5 mg/day for 9.1 ± 1.4 days. The diabetogenic potential of prednisolone was reinforced by the intake of a high...

  20. ADOLESCENTS’ HEALTHY EATING

    DEFF Research Database (Denmark)

    Pedersen, Susanne

    This PhD thesis contributes with knowledge about adolescent healthy eating by studying consumer socialisation, social influence and behavioural change in relation to adolescent healthy eating. The introduction provides the important reasons for studying adolescents and healthy eating and explains...... that a more holistic approach is needed in order to respond to the rising levels of overweight among adolescents. It is important to understand the development of and influences on adolescent healthy eating behaviour and the possibilities for promoting healthy eating through interventions. By reviewing...... relevant literature on consumer socialisation, social influence and behaviour change through interventions employing feedback in relation to adolescent healthy eating, it is argued that a socio-cognitive approach to consumer socialisation and behaviour change provides a richer and more nuanced...

  1. Determinants of nursing students' healthy life style

    Directory of Open Access Journals (Sweden)

    Nurcan Özyazıcıoğlu

    2011-07-01

    Full Text Available This descriptive research was carried out to determine the demographic characteristics that effect of healthy life style behavior of the students at Uludağ University. The study sample included 336 students in School of Health. The healthy life style behavior scale (HLSB-II was used to measure healthy life style behaviors. The total scores HLSB scale-II of students (128.97 ±16.40, subscales health responsibility (29.75 ± 4.19, physical activity (16.60 ± 4.24, nutrition (19.40 ± 3.73, spiritual growth (26.93 ± 4.06, interpersonal relationships (26.16 ± 4.25 and stress management (19.44 ± 3.57 were found. The student nurses performed the best in health responsibility but the worst in physical activity. It was also found that girls more than men have a high average in total average. Students' income level is found to influence the ability to deal with the nutrition. As a result, healthy life style behavior of students was generally found to be medium level in this study. Students should be empowered to make healthy choices, and appropriate health education interventions should be developed.

  2. Healthy eating at school

    DEFF Research Database (Denmark)

    Bruselius-Jensen, Maria Louisa; Egberg Mikkelsen, Bent

    Unhealthy eating are common among adolescents and the school is a well suited setting for promoting healthy eating. For the school to play a role here, however an environment must be created, in which the school and the students develop a sense of ownership for a healthy food and nutrition "regime...... catering. Therefore in designing school meal programs aiming at being supportive for healthy eating, it is necessary to try to integrate the food provision in the life of the school....

  3. HIV risk behavior among men who have sex with men

    Directory of Open Access Journals (Sweden)

    Vijay Silan

    2013-01-01

    Full Text Available Background: Sentinel surveillance reported high human immunodeficiency virus positivity rates among men who have sex with men. The current study has described the high-risk behavior and self-reported sexually transmitted infection(s among self-identified men who have sex with men. Aims: The present study was to find out the extent of high-risk behavior and prevalence of self-reported sexually transmitted diseases among self-identified men who have sex with men, registered with selected nongovernmental organizations in Delhi. Materials and Methods: A facility-based cross-sectional study was done among 250 men who have sex with men during March 2009 to February 2010, through consecutive sampling strategy. Results: Majority (80% were anal-receptive, received money for sex (61% and were involved in all types of sexual intercourse with men (oral-86%, manual-97%, and anal-94%. Consistent condom use with male partner was low (46%, most common reason (52% for not using condom was, that either the condoms were not available or the partner objected. Self-reported sexually transmitted infection(s was 41% in the past 12 months. Conclusions: This study underscores the increased vulnerability of men who have sex with men of Delhi and need for sustained interventions.

  4. HPV Infection in Men

    OpenAIRE

    Palefsky, Joel M.

    2007-01-01

    While much is known about the natural history of cervical human papillomavirus (HPV) infection and its consequences, including cervical intraepithelial neoplasia and cervical cancer, relatively little is known about the natural history of anogenital HPV infection and diseases in men. In part this reflects difficulties in penile sampling and visual assessment of penile lesions. Anal HPV infection and disease also remain poorly understood. Although HPV is transmitted sexually and infects the ge...

  5. Transgender men and pregnancy

    OpenAIRE

    Obedin-Maliver, Juno; Makadon, Harvey J.

    2015-01-01

    Transgender people have experienced significant advances in societal acceptance despite experiencing continued stigma and discrimination. While it can still be difficult to access quality health care, and there is a great deal to be done to create affirming health care organizations, there is growing interest around the United States in advancing transgender health. The focus of this commentary is to provide guidance to clinicians caring for transgender men or other gender nonconforming peopl...

  6. Het God mens geword ?

    Directory of Open Access Journals (Sweden)

    J. H. van Wyk

    1977-06-01

    Full Text Available Dit mag miskien verrassend klink om hierdie vraag ter sprake te bring en dit sal ook nie verbasend wees indien iemand sy wenkbroue lig by die hoor van hierdie problematiek nie. Trouens, sedert Anselmus sy beroemde Cur deus homo die lig laat sien het en sedert Karl Barth hierdie uitdrukking tallose male gebruik het, het dit gemeengoed geword in die teologiese en selfs kerklike wêreld om te praat van ‘God wat mens geword het’.

  7. Nocturia in older men.

    Science.gov (United States)

    van Doorn, Boris; Bosch, J L H Ruud

    2012-01-01

    Nocturia is a common and bothersome symptom that impacts on sleep-quality and quality of life. Nocturia often has a multi-factorial etiology which makes thorough assessment of the complaint indispensable. This review summarizes the definition of nocturia, its epidemiology, clinical presentation, pathophysiology, diagnostics, and treatment options with special reference to older men. Nocturia is defined as a nocturnal voiding frequency of two or more, based on impact on quality of life. It is very prevalent in older men. Apart from the negative effects of sleep-disruption, it may be a risk-factor for hip fractures and increased mortality. Most common causes are: nocturnal polyuria, 24-h polyuria, overactive bladder (sometimes due to BPH) and sleep disturbance. A clear understanding of the etiology in the individual patient is indispensable when addressing the various possible causes and co-morbidities. Most important tool for this is the frequency-volume chart, but also patient history, physical examination and serum analysis. For treatment, lifestyle adjustments are often helpful. Medical therapy with 5-alpha reductase inhibitors, alpha-blockers, a combination of the two, or anti-muscarinics, has a limited effect. Most important medical option is desmopressin (arginine vasopressin analogue); however, treatment with this drug is limited to men under 65 years mainly due to the risk of hyponatraemia. PMID:22079871

  8. Satisfied Men Live Longer

    Institute of Scientific and Technical Information of China (English)

    Suzanne; Rostler; 尤北还

    2001-01-01

    作为上篇的一个姊妹篇,我们很乐意向读者推荐本文。古人云,知足常乐。读完本文,也许你会改其二字:知足长寿。文章告诉我们: Men who reported high levels of satisfaction with their lives were more likely to be alive 20 years later. 知足者竟然能在这个世界上多生活20年!你信否? 文章还提到了男女之别,颇发人深省: It seems to me that the coping abilities of women with distress and dissatisfaction may be better than in men. Men who feel dissatisfied might cope with their feelings by abusing alcohol, smoking and not exercising while women might talk to friends or seek professional help. 你若是男性读者,是否可以从中得到某种启迪? 文章最精彩的句子大概在文末: It is not enough for a human being to earn money and be in physically good condition. One should respect mental health as well.】

  9. Healthy Weights for Healthy Older Adults

    Science.gov (United States)

    ... and Conditions Allergies and Intolerances Wellness Pregnancy Topics Travel Your Health and Your Weight Kidney Disease Food Allergies Healthy ... ready to help you create the change to improve your life. Search Now Food Fitness Health Learn More About Us What an RDN Can ...

  10. [Analysis of factors affecting anaerobic threshold in healthy subjects].

    Science.gov (United States)

    Nitta, Y; Nagatsuka, K; Inage, T; Yokoi, H; Inaoka, Y; Kawanishi, K; Sakamoto, S; Ishikawa, K

    1992-03-01

    The anaerobic threshold (AT) is used to determine the exercise capacity in patients with heart failure and healthy subjects. To determine the factors affecting AT, we determined the AT in healthy subjects, and examined the factors that determine AT in healthy subjects. One hundred and sixteen healthy subjects (79 men and 37 women) performed on a bicycle a stepwise increasing submaximal exercise. During the work test the parameters usually used in the detection of AT (Vo2, Vco2, VE), blood pressure, heart rate and oxygen saturation were recorded by a computerized system every minute. AT was determined from changes in ventilation and gas-exchange. The fat index was calculated from height and body weight measured at the beginning of the ventilatory function test. A significant correlation was obtained between AT and age, AT and fat index, AT and %VC, AT and maximum heart rate during exercise, AT and recovery rate of heart rate after exercise, and AT and Vo2 at rest. In addition, we examined the relationship among the parameters in 4 groups according to sex and age (30-49; younger, 50-69; older), because sex and age affected most parameters. We found a significant correlation between AT and fat index (older men and women), AT and %VC (younger and older women), AT and Vo2 at rest (younger and older men). We considered that the main factors that determined AT in healthy subjects were age, sex, fat index, %VC and Vo2 at rest. PMID:1518183

  11. Motivational Interviewing Targeting Risky Sex in HIV-Positive Young Thai Men Who Have Sex with Men

    OpenAIRE

    Rongkavilit, Chokechai; Wang, Bo; Naar-King, Sylvie; Bunupuradah, Torsak; Parsons, Jeffrey T.; Panthong, Apirudee; Koken, Juline A.; Saengcharnchai, Pichai; Phanuphak, Praphan

    2014-01-01

    Motivational interviewing (MI) has been shown to reduce sexual risks among HIV-positive men who have sex with men (HMSM) in the U.S. We conducted a randomized trial of Healthy Choices, a 4-session MI intervention, targeting sexual risks among 110 HIV-positive youth ages 16–25 years in Thailand. Risk assessments were conducted at baseline, 1 month, and 6 months post-intervention. This report presents the analysis of 74 HMSM in the study. There were 37 HMSM in the Intervention group and 37 in t...

  12. Promoting Healthy Dietary Behaviors.

    Science.gov (United States)

    Perry, Cheryl L.; Story, Mary; Lytle, Leslie A.

    This chapter reviews the research on promoting healthy dietary behaviors in all youth, not just those who exhibit problems such as obesity or eating disorders. The first section of this chapter presents a rationale for addressing healthy dietary behavior with children and adolescents, on the basis of the impact of these behaviors on short- and…

  13. Healthy Life Style

    OpenAIRE

    Donát, Lukáš

    2008-01-01

    The diploma thesis deals with a healthy life style and its influence on the most frequent civilization diseases. In the subsequent parts there has been elaborated a questionnaire with the main topic -- healthy life style. Based on this questionnaire are also the results which confirm or contradict the hypotheses formulated in the process of the presented diploma thesis.

  14. Healthy ageing through music

    OpenAIRE

    Perkins, Rosie; Bisschop Boele, E.H.; Smilde, Rineke

    2012-01-01

    Presentation in session ‘Healthy Ageing through Music’. Presentations: - Rineke Smilde: Music and Dementia - Evert Bisschop Boele: Creative Workshops with the Elderly - Rosie Burt-Perkins: Healthy ageing through instrumental music learning World Conference ISME, Thessaloniki, Greece, 20/7/2012

  15. "Healthy" Human Development Indices

    Science.gov (United States)

    Engineer, Merwan; Roy, Nilanjana; Fink, Sari

    2010-01-01

    In the Human Development Index (HDI), life expectancy is the only indicator used in modeling the dimension "a long and healthy life". Whereas life expectancy is a direct measure of quantity of life, it is only an indirect measure of healthy years lived. In this paper we attempt to remedy this omission by introducing into the HDI the morbidity…

  16. Voice Loudness and Gender Effects on Jitter and Shimmer in Healthy Adults

    Science.gov (United States)

    Brockmann, Meike; Storck, Claudio; Carding, Paul N.; Drinnan, Michael J.

    2008-01-01

    Purpose: The aim of this study was to investigate voice loudness and gender effects on jitter and shimmer in healthy young adults because previous descriptions have been inconsistent. Method: Fifty-seven healthy adults (28 women, 29 men) aged 20-40 years were included in this cross-sectional single-cohort study. Three phonations of /a/ at soft,…

  17. MEN OF PEACE

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    On February 7,Chinese peacekeepers receive UN peace medals in Wau,Sudan,from Ashraf Qazi,Special Representative of the UN Secretary General for Sudan. The conferring ceremony was held to honor great contributions made by the Chinese peacekeeping troops in maintaining peace and stability in Sudan’s war-torn Darfur region. By honoring both security and logistics units,Qazi highly praised Chinese soldiers as true men of peace. As part of the UN Mission in Sudan,China joined the peacekeeping operation in 2006.

  18. Men of physics

    CERN Document Server

    Seeger, Raymond J

    2013-01-01

    Men of Physics: Galileo Galilei, His Life and His Works deals with Galileo Galilei's radical discoveries and trail during the Inquisition. The book describes the life of Galileo and his many interests in art and music, in addition to science. Galileo is born in Pisa in 1564, and at age 25, he is appointed to the Chair of Mathematics at the University of Pisa. He writes several papers, for example, mathematical continuum as contrasted with physical atomism, and investigates the behavior of magnetic poles. He believes in William Gilbert's experiment that the earth itself is a large magnet. He c

  19. Measures and men

    CERN Document Server

    Kula, Witold

    2014-01-01

    Measures and Men, considers times and societies in which weighing and measuring were meaningful parts of everyday life and weapons in class struggles. Originally published in 1986. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These paperback editions preserve the original texts of these important books while presenting them in durable paperback editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heri

  20. Regurgitation in healthy and non healthy infants

    OpenAIRE

    Cavallo Luciano; Raimondi Francesco; Riezzo Giuseppe; Indrio Flavia; Francavilla Ruggiero

    2009-01-01

    Abstract Uncomplicate regurgitation in otherwise healthy infants is not a disease. It consists of milk flow from mouth during or after feeding. Common causes include overfeeding, air swallowed during feeding, crying or coughing; physical exam is normal and weight gain is adequate. History and physical exam are diagnostic, and conservative therapy is recommended. Pathologic gastroesophageal reflux or gastroesophageal reflux disease refers to infants with regurgitation and vomiting associated w...

  1. Men at sport: gay men's experiences in the sport workplace.

    Science.gov (United States)

    Cavalier, Elizabeth S

    2011-01-01

    Research on sexual identity and sport has revealed a shifting narrative about the experiences of gay men. While some suggest the atmosphere is hostile, others posit that homophobia and sexual prejudice are playing less of a role in gay men's experiences. This research focuses on the experiences of 10 gay men working in professional, collegiate, and club sport, as part of a larger dataset of 37 male and female employees. Five of the men were overtly and publicly out at work, while five were closeted (to varying degrees). This article focuses on three themes for gay men working in sport: 1) the importance of coming out in the workplace; 2) the role of the locker room as a contested terrain, and 3) the disconnect between their experiences at work and their perceptions of the workplace environment as negative or positive. Men in this study were basing their impressions on their total experience in sport (as current and former players, as employees, and as fans). It also suggests that the public "story" of gay men working in sport represents one of two extremes-either the proverbial "horror story," or the extremely positive representation of gay men's experiences. This research suggests that gay men's experiences in sport are more complex and nuanced than the public narrative implies. PMID:21534074

  2. Planning For a Healthy School Year: Healthy Eating

    Science.gov (United States)

    ... on. Feature: Planning For A Healthy School Year Healthy Eating Past Issues / Fall 2015 Table of Contents How ... federal government releases a set of guidelines on healthy eating. The guidelines suggest balancing calories with physical activity. ...

  3. Varicocele and Infertility in Men

    Science.gov (United States)

    Freiha, Fuad; Mroueh, Adnan

    1976-01-01

    Varicocele is an important cause of infertility in men. The exact mechanism by which varicocele depresses spermatogenesis is unknown but probably the retrograde flow of blood rich in catecholamines into the testes plays a major role. Because subfertile semen qualities are present in a large percentage of men with varicocele and because the response to surgical procedures is very good, high ligation of the left internal spermatic vein is recommended in men with varicocele and infertility. PMID:1007247

  4. Hormonal determinants of the severity of andropausal and depressive symptoms in middle-aged and elderly men with prediabetes

    Directory of Open Access Journals (Sweden)

    Rabijewski M

    2015-08-01

    Full Text Available Michał Rabijewski,1 Lucyna Papierska,2 Roman Kuczerowski,1 Paweł Piątkiewicz11Department of Internal Diseases, Diabetology and Endocrinology, Medical University of Warsaw, 2Department of Endocrinology, Medical Centre for Postgraduate Education, Warsaw, PolandAbstract: Andropausal and depressive symptoms are common in aging males and may be associated with hormone deficiency. We investigated the severity of andropausal and depressive symptoms, as well as their hormonal determinants, in 196 middle-aged and elderly men (age range: 40–80 years with prediabetes (PD and in 184 healthy peers. PD was diagnosed according to the definition of the American Diabetes Association. The severity of andropausal and depressive symptoms was assessed using the Aging Males’ Symptoms Rating Scale and the Self-Rating Depression Scale. Total testosterone (TT, calculated free testosterone (cFT, dehydroepiandrosterone sulfate (DHEAS, and insulin-like growth factor 1 (IGF-1 were measured. The prevalence of andropausal syndrome in men with PD was significantly higher than that in healthy men (35% vs 11%, respectively. In men with PD aged 40–59 years, the severity of sexual, psychological, and all andropausal symptoms was greater than in healthy peers, while in elderly men (60–80 years, only the severity of psychological symptoms was greater than in healthy peers. The severity of depressive symptoms in the middle-aged men with PD was greater than in healthy peers, while the severity of depressive symptoms in elderly men with PD and healthy peers was similar. The higher prevalence of andropausal symptoms was independently associated with cFT and IGF-1 in middle-aged men and with TT and DHEAS in elderly men with PD. The more severe depression symptoms were associated with low TT and DHEAS in middle-aged men and with low cFT and DHEAS in elderly men with PD. In conclusion, the prevalence of andropausal symptoms, especially psychological, was higher in prediabetic

  5. Healthy Conflict Management

    OpenAIRE

    Brower, Naomi

    2012-01-01

    Without healthy conflict management skills, conflict can often escalate or intensify over time. This fact sheet gives tips on utilizing key negotiation skills to help individuals effectively address and cope with conflict and potentially build stronger relationships with others.

  6. Getting Healthy Scientifically

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Recently,Zhao Zhixin,a Beijing-based instructor on scientific bodybuilding and public sport,was interviewed by China Youth Daily,sharing his views on how to get healthy scientifically.Edited excerpts follow:

  7. Eating Healthy Ethnic Food

    Science.gov (United States)

    ... with ethnic foods. Here's a sample of healthy food choices (lower in calories and fat) and terms to look for when making your selection: Chinese Zheng (steamed) Jum (poached) Kao (roasted) Shao (barbecued) ...

  8. Making Healthy Sexual Decisions

    Science.gov (United States)

    ... right reasons? (It shouldn’t be based on peer pressure, a need to fit in or make your ... ready! Tags: birth control , condoms , contraception , healthy sex , peer pressure Related Content Talking With Your Partner about Condoms ...

  9. Expect Respect: Healthy Relationships

    Science.gov (United States)

    ... Listen Español Text Size Email Print Share Expect Respect: Healthy Relationships Page Content Article Body Signs of ... good about what happens when they are together. Respect You ask each other what you want to ...

  10. Staying Healthy After Menopause

    Science.gov (United States)

    ... Javascript on. Feature: Menopause: A Woman's Change of Life Staying Healthy After Menopause Past Issues / Spring 2013 Table of Contents ... changed. Read More "Menopause: A Woman's Change of Life" Articles Understanding ... After Menopause Spring 2013 Issue: Volume 8 Number 1 ...

  11. Healthy food trends -- flaxseeds

    Science.gov (United States)

    Flaxseeds contain fiber, vitamins, minerals, protein, healthy plant-based fats, and antioxidants that help prevent cell damage. Flaxseeds are a good source of soluble and insoluble fiber which help ...

  12. Disparities -- Healthy People 2020

    Science.gov (United States)

    ... County Data Resources Federal Prevention Initiatives Healthy People eLearning Program Planning Content Syndication Tools for Professionals Public Health 3.0 Webinars & Events Webinars & Events Archive About ...

  13. The healthy human microbiome

    OpenAIRE

    Lloyd-Price, Jason; Abu-Ali, Galeb; Huttenhower, Curtis

    2016-01-01

    Humans are virtually identical in their genetic makeup, yet the small differences in our DNA give rise to tremendous phenotypic diversity across the human population. By contrast, the metagenome of the human microbiome—the total DNA content of microbes inhabiting our bodies—is quite a bit more variable, with only a third of its constituent genes found in a majority of healthy individuals. Understanding this variability in the “healthy microbiome” has thus been a major challenge in microbiome ...

  14. Healthy Aging in China

    OpenAIRE

    Smith, James P.; Strauss, John; Zhao, Yaohui

    2014-01-01

    China has aged rapidly and the rate is accelerating in decades to come. We review positive and negative forces for healthy aging in China now and in the future. The most positive force is the spectacular growth in education over time especially for Chinese women, which should improve all dimensions of cognitive and physical health and eliminate vast gender disparities in healthy aging that currently exist.

  15. Healthy lifestyle in teachers

    OpenAIRE

    Pirzadeh, Asiyeh; Sharifirad, Gholamreza; Kamran, Aziz

    2012-01-01

    Introduction: The role of individual healthy behaviors like physical activity, nutrition and stress management on reduction of rate of disease mortality and morbidity is well known. The aim of this study is to determine healthy life style in teachers employed in district No.4 in Isfahan, Iran, in 2010. Materials and Methods: The participants of this cross-sectional study were 96 teachers in district No. 4, selected via random sampling method. The data collection was performed using a question...

  16. The healthy human microbiome.

    Science.gov (United States)

    Lloyd-Price, Jason; Abu-Ali, Galeb; Huttenhower, Curtis

    2016-01-01

    Humans are virtually identical in their genetic makeup, yet the small differences in our DNA give rise to tremendous phenotypic diversity across the human population. By contrast, the metagenome of the human microbiome-the total DNA content of microbes inhabiting our bodies-is quite a bit more variable, with only a third of its constituent genes found in a majority of healthy individuals. Understanding this variability in the "healthy microbiome" has thus been a major challenge in microbiome research, dating back at least to the 1960s, continuing through the Human Microbiome Project and beyond. Cataloguing the necessary and sufficient sets of microbiome features that support health, and the normal ranges of these features in healthy populations, is an essential first step to identifying and correcting microbial configurations that are implicated in disease. Toward this goal, several population-scale studies have documented the ranges and diversity of both taxonomic compositions and functional potentials normally observed in the microbiomes of healthy populations, along with possible driving factors such as geography, diet, and lifestyle. Here, we review several definitions of a 'healthy microbiome' that have emerged, the current understanding of the ranges of healthy microbial diversity, and gaps such as the characterization of molecular function and the development of ecological therapies to be addressed in the future. PMID:27122046

  17. Healthy Mouth for Your Baby

    Science.gov (United States)

    ... providing oral care. NIDCR > OralHealth > Topics > Tooth Decay (Caries) > A Healthy Mouth for Your Baby A Healthy ... you about other things such as a healthy diet and fluoride that can keep your child’s mouth ...

  18. Men's health is evolving

    Institute of Scientific and Technical Information of China (English)

    Run Wang; Wayne J. G

    2008-01-01

    @@ The Asian Journal of Andrology (AJA) is growing at a fast pace and becoming one of the leading journals in the field of andrology thanks to the leadership of Prof. Yi-Fei Wang, Editor-in-Chief of AJA, and the hard work of the AJA editorial staff. It was the spring of 2006 in Chicago when Ms. Dan-Qing Ren, Scientific Editor of the AJA, first approached us at the 31st American Society of Andrology (ASA) Annual Meeting regarding publishing a special issue on men's health. We were honored by the invitation to be guest editors for this special issue. We discussed potential topics with many of the contributors while Ms. Qin-Zhu Zheng, Editorial Director of the AJA worked out the details and met with us at the 32nd ASA Annual Meeting in Tampa, Florida. We are very pleased to present this issue of superior articles with contributions by internationally recognized authorities.

  19. From Sharks to Men

    Directory of Open Access Journals (Sweden)

    StefanBurdach

    2013-05-01

    Full Text Available Men and sharks are both jawed vertebrates at the top of the food chain. Sharks are the first extant to develop adaptive immunity preserved to man throughout jawed vertebrates. We hy-pothesize here, that T cell receptor / major histocompatibility complex (TCR/MHC interac-tions developed as the defense mechanism of carnivors against takeover by their victims‘ cells derived pathogens. Germline encoded TCR segments have been conserved in evolution, providing the MHC bias of TCR. Ancestor genes of MHC polymorphisms may have first de-veloped as a mating preference system, that later in evolution provided host immune respons-es destroying infectious nonself, yet maintaining tolerance to self. Pathogens may thus have simultaneously selected for alloimmunity. Allorejection has been observed in sharks and men. Cannibalism is a common ecological in-teraction in the animal kingdom, especially prevalent in aquatic communities; it favours selec-tion of intraspecies allo responses for defence of self integrity. Alloreactive T-cells do not undergo negative selection of strong TCR/MHC interactions; thus, they react stronger than self-MHC recognizing T cells. High levels of genetic diversity at MHC genes play a critical role in protecting populations of vertebrate species from contagious cells displaying stemness and homing features, including cancer cells. Recognition of self-MHC fails especially in dis-eases, which predominantly arise with age and after the peak of reproduction, e.g. cancer. So far, the treatment of malignant disease with autologous T-cells has widely failed. Allorecogni-tion constitutes an extremely powerful mechanism in evolution, which may be employed in immunotherapy of cancer by MHC disparate, e.g. haploidentical transplantation and consecu-tive treatment with T cells from the donor parents recognizing tumor selective peptides pre-sented by the non-inherited haplotype on the tumor.

  20. Normative references of heart rate variability and salivary alpha-amylase in a healthy young male population

    OpenAIRE

    Kobayashi Hiromitsu; Park Bum-Jin; Miyazaki Yoshifumi

    2012-01-01

    Abstract Background This study aimed to present normative reference values of heart rate variability and salivary alpha-amylase in a healthy young male population with a particular focus on their distribution and reproducibility. Methods The short-term heart rate variability of 417 young healthy Japanese men was studied. Furthermore, salivary alpha-amylase was measured in 430 men. The average age of the subjects were 21.9 years with standard deviation of 1.6 years. Interindividual variations ...

  1. Thyroid-Stimulating Hormone Is Significantly Associated with Bone Health Status in Men

    OpenAIRE

    Chin, Kok-Yong; Ima-Nirwana, Soelaiman; Mohamed, Isa Naina; Aminuddin, Amilia; Johari, Mohamad Hanapi; Ngah, Wan Zurinah Wan

    2013-01-01

    Background and Aim: Recent studies revealed a novel association between thyroid-stimulating hormone (TSH) and bone health status in healthy male populations. The present study aimed to validate this association and provide new information on the relationship between TSH levels and calcaneal speed of sound (SOS) in men. Methods: This cross-sectional study recruited 681 men with complete data of calcaneal SOS, body anthropometry, serum TSH, free triiodothyronine (FT3) and free thyroxine (FT4) l...

  2. Diminished emotion expressivity but not experience in men and women with schizophrenia

    OpenAIRE

    Mote, Jasmine; Stuart, Barbara K.; Kring, Ann M.

    2014-01-01

    Prior studies indicate that men with schizophrenia are less outwardly expressive but report similar emotion experience as healthy people. However, it is unclear whether women with schizophrenia show this same disconnect between expressivity and experience. Men (n=24) and women (n=25) with schizophrenia or schizoaffective disorder and women without schizophrenia (n=25) viewed emotionally evocative film clips and were video recorded to assess facial expressivity. Participants also reported thei...

  3. Planing disorders in men with schizophrenia and in men with localized frontal lobe lesions [Zaburzenia planowania u mężczyzn chorych na schizofrenię lub z ogniskowymi uszkodzeniami płatów czołowych

    Directory of Open Access Journals (Sweden)

    Rutkowska, Aleksandra

    2013-10-01

    Full Text Available Aim. Planning disorders have been observed in people with frontal lobe lesions for many decades. There’s also growing body of evidence of frontal dysfunction in people with schizophrenia. The aim of this study is to compare the planning abilities in men with schizophrenia, men with localized frontal lobe lesions and healthy men.Method. A sample of 90 men participated in the study. They were divided into three groups: men with schizophrenia (n=30, men with localized frontal lobe lesions (n=30 and healthy men (n=30 as a control group. Planning abilities were assessed with a clinical trialbased on Tower of London task. Results. Significant differences in ToL measures were found between controls and men with schizophrenia (Trials solved: p<0.01; Trials solved perfectly: p<0.05; Execution time: p<0.001 and between controls and men with frontal lobe lesions (Trials solved: p<0.001;Thinking time: p<0.05; Execution time: p<0.001. No significant differences were found between schizophrenia and frontal lobe lesion groups.Conclusions. Similar deficits in planning and solving problems, which require planning, may be observed in men with schizophrenia and men with frontal lobe lesions. In both groups time spent on thinking is less effective than in healthy men. Not only quantitative, but also qualitative assessment should be carried when examining patients’ performance on Tower of London task.

  4. Determinants of nursing students' healthy life style

    Directory of Open Access Journals (Sweden)

    Nurcan Özyazıcıoğlu

    2011-07-01

    Full Text Available Normal 0 21 false false false TR X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Normal Tablo"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman","serif";} This descriptive research was carried out to determine the demographic characteristics that effect of healthy life style behavior of the students at Uludağ University. The study sample included 336 students in School of Health. The healthy life style behavior scale (HLSB-II was used to measure healthy life style behaviors.          The total scores HLSB scale-II of students (128.97 ±16.40, subscales health responsibility (29.75 ± 4.19, physical activity (16.60 ± 4.24, nutrition (19.40 ± 3.73, spiritual growth (26.93 ± 4.06, interpersonal relationships (26.16 ± 4.25 and stress management (19.44 ± 3.57 were found. The student nurses performed the best in health responsibility but the worst in physical activity. It was also found that girls more than men have a high average in total average. Students' income level is found to influence the ability to deal with the nutrition.          As a result, healthy life style behavior of students was generally found to be medium level in this study. Students should be empowered to make healthy choices, and appropriate health education interventions should be developed.

  5. African American men's perspectives on promoting physical activity: "We're not that difficult to figure out!".

    Science.gov (United States)

    Friedman, Daniela B; Hooker, Steven P; Wilcox, Sara; Burroughs, Ericka L; Rheaume, Carol E

    2012-01-01

    African American men report poorer health than do White men and have significantly greater odds for developing chronic diseases partly because of limited physical activity. Understanding how to encourage healthy behaviors among African American men will be critical in the development of effective physical activity messages and programs. Guided by principles of cultural sensitivity and social marketing, this research examined middle-aged and older African American men's recommended strategies for promoting physical activity to African American men of their age. The authors report results from 49 interviews conducted with middle-aged (45-64 years) and older (65-84 years) African American men in South Carolina. Four groups of African American men were recruited: middle-aged active men (n = 17), middle-aged inactive men (n = 12), older active men (n = 10), older inactive men (n = 10). Themes related to marketing and recruitment strategies, message content, and spokesperson characteristics emerged and differed by age and physical activity level. Recommended marketing strategies included word of mouth; use of mass media; partnering with churches, businesses, and fraternities; strategic placement of messages; culturally appropriate message framing; and careful attention to selection of program spokespersons. Findings will help in the marketing, design, implementation, and evaluation of culturally appropriate interventions to encourage physical activity among middle-aged and older African American men in the South. PMID:22808914

  6. Healthy Buildings '88

    International Nuclear Information System (INIS)

    The Healthy Buildings '88 Conference focuses on the technical solutions and functional requirements contributing to Healthy Buildings for people to live and work in. The main object of the Conference is to give architects, consultants, real-estate owners and manufacturers of building materials recommendations on choice of materials and choice of systems and on how to combine materials and systems. The program includes overview lectures, plenary symposia with invited speakers, workshops, poster presentations and an exhibition of scientific, educational and technical material. One part of the conference is devoted to the problem of radon in residential buildings

  7. Computerised measurements of QT dispersion in healthy subjects

    OpenAIRE

    Gang, Y; Guo, X; Crook, R; Hnatkova, K; Camm, A; M. Malik

    1998-01-01

    Objective—To assess the stability and reproducibility of computerised QT dispersion (QTd) measurement in healthy subjects, as this is presently being incorporated into commercial electrocardiographic systems.
Methods—70 healthy volunteers (mean (SD) age 38 (10) years, 35 men, 35 women) with a normal 12 lead electrocardiogram (ECG) were studied. From each subject, 70 ECG recordings were taken using the MAC VU ECG recorder (Marquette). In study A, 50 ECGs were recorded in each subject: 10 supin...

  8. Dieting Habits of Men.

    Science.gov (United States)

    Vining, Virginia L; Cotugna, Nancy; Fang, Chengshun; Sue Snider, O

    2016-08-01

    There is little research involving the US male population regarding weight control and behavior that may affect weight status. Gender-specific weight-control programs for men aren't the standard. Our study objectives were to survey dieting and health habits of an adult male employee population and to determine if the population would be interested in gender-specific programming. Demographics, weight-control practices and interest in gender-specific weight-control programs were examined cross sectionally. A 50-question web-based survey was posted via email from October 2-30, 2014 to male employees at a Mid-Atlantic university. Statistical analyses included frequencies, means and percentages. Chi square and t tests were conducted. The 254 participants were ages 18-65+ years, predominantly white, college educated with annual incomes above $50,000. Sources of nutrition knowledge ranged from a high of web sites (65 %) to a low of registered dietitians (9 %). Macronutrient restrictions reported for dieting were carbohydrates 77 %, fats 40 % and protein 19 %. The >30 age group was more likely to have: decreased amount of food intake P = .001), reducing overall calories (P = .047), skipping meals (P = .006) or trying commercial programs (P = .011). There was nothing of significance for those motivation for males to lose and maintain weight loss. PMID:26758439

  9. Smart Substitutions for Healthy Cooking

    Science.gov (United States)

    ... to the Terms and Conditions and Privacy Policy Healthy Eating • Healthy Eating Home • Nutrition AHA Diet and Lifestyle Recommendations Making ... and Conditions and Privacy Policy Nutrition Quizzes & Tools Healthy Eating Quiz Wondering if you're eating healthy? Take ...

  10. Healthy Bones Matter

    Science.gov (United States)

    ... think that this is something that only older people need to worry about. BUT—you can take action right now to help make sure that as you get older your bones are as healthy as they can be. Eating a balanced diet ...

  11. Managing for Healthy Ecosystems

    OpenAIRE

    Rapport, D.; Lasley, B.; Rolston, D; Nielsen, O.; Qualset, C. O.; Damania, A.

    2003-01-01

    Metadata only record One of the critical issues of our time is the dwindling capacity of the planet to provide life support for a large and growing human population. Based on a symposium on ecosystem health, Managing for Healthy Ecosystems identifies key issues that must be resolved if there is to be progress in this complex area, such as:

  12. Some like it healthy

    DEFF Research Database (Denmark)

    Contini, Caterina; Casini, Leonardo; Stancu, Violeta;

    2015-01-01

    Authorising new health claims in Europe will favour the diffusion on the market of a greater number of foods with health claims. This scenario presents new opportunities to promote healthy food choices and launches new challenges to define strategies aimed at promoting products on the market. The...

  13. Enjoy healthy eating

    OpenAIRE

    Public Health Agency

    2010-01-01

    This leaflet aims to increase public awareness and understanding of healthy eating messages. The leaflet includes the new eatwell plate, information on the five main food groups, along with top tips for cutting down on fat and what to choose when eating out. It also includes sections on the importance of breakfast and cutting down on salt.

  14. Pregnancy and Healthy Weight

    Science.gov (United States)

    ... suggests that women need to think about a healthy pregnancy before they even start trying to get pregnant, and that taking actions to improve their health can greatly improve their babies’ health, both at birth and later in life. For example, research from the NICHD and other organizations led the ...

  15. The Healthy Eating Pyramid

    Institute of Scientific and Technical Information of China (English)

    Jimmy; Lin

    2007-01-01

    Experts from the Harvard School of Public Health created the Healthy Eating Pyramid.The pyramid is about the links between diet and health and offers useable information to help people make better choices about what to eat. Remember:its base is daily exercise and weight control.

  16. Healthy eating at schools

    DEFF Research Database (Denmark)

    Sabinsky, Marianne

    healthy eating. In Denmark most children eat a packed lunch brought from home. It is challenging to collect dietary data from a pediatric population where recall problems exist and estimation of portion sizes can be complicated. Thus, to measure and assess the dietary effect of an intervention, new valid...

  17. The bomb and the men

    International Nuclear Information System (INIS)

    Since 1945, more than 2000 nuclear weapon tests have been performed in the world, with a perfect knowledge of the irradiation risks. This book tells this story. The one of the men who designed the bombs, who used and improved them. It tells also the story of these men who were injured by nuclear weapons and those who were directly impacted by the fallouts of these tests. Finally, the book does not forget to mention the men who voluntarily dissimulated the ravages of nuclear weapons before discretely recognizing them and thinking of repairing the damage

  18. "I'm ready to eat and grab whatever I can get": Determinants and patterns of African American men's eating practices.

    Science.gov (United States)

    Griffith, Derek M; Wooley, Alana M; Allen, Julie Ober

    2013-03-01

    This article examines determinants and patterns of African American men's dietary practices. Thematic content analysis was used to analyze data from nine exploratory focus groups conducted with 83 urban, middle-aged and older African American men from southeast Michigan. The men distinguished between healthy and unhealthy foods and "meals" versus other instances of eating. Eating patterns and content differed depending on the meal, work and family schedules, food availability, and whether it was a weekday or weekend. When eating alone or outside the home, men prioritized convenience and preferences for tasty, unhealthy foods. Men often reported skipping breakfast or lunch and grabbing snacks or fast food during the day. They emphasized sharing dinner with their spouses and families-usually a home-cooked, "healthy" meal. On weekends, spouses often cooked less and men snacked and dined out more frequently. Sunday dinners involving favorite, unhealthy comfort foods were the highlight of men's eating practices. African American men tended not to follow healthy eating recommendations because of their busy lives, reliance on spouses to prepare food, and preferences for unhealthy foods. These findings suggest that healthy eating interventions must consider how the contexts of African American men's lives shape their eating practices. PMID:22773618

  19. Health Inequities among Men who have Sex with Men

    Centers for Disease Control (CDC) Podcasts

    2010-09-22

    Dr. Richard Wolitski, Deputy Director for Behavioral and Social Science in CDC's Division of HIV/AIDS Prevention, discusses how the health of men who have sex with men may be influenced by prejudice and discrimination and impacted by policies, laws, and economic factors.  Created: 9/22/2010 by National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention.   Date Released: 9/22/2010.

  20. Pulmonary function in healthy young adult Indians in Madras.

    OpenAIRE

    Vijayan, V. K.; Kuppurao, K V; Venkatesan, P; Sankaran, K; Prabhakar, R

    1990-01-01

    Forced vital capacity, forced expiratory volume in one second, functional residual capacity, residual volume, total lung capacity, and single breath diffusing capacity measurements (effective alveolar volume, carbon monoxide transfer factor, and transfer coefficient) were measured in 247 young healthy adults (130 male, 117 female) aged 15-40 years living in Madras. Subjects were of Dravidian stock, living at sea level with rice as their staple diet. Regression equations were derived for men a...

  1. Effects of Acute Resistance Exercise on Arterial Stiffness in Young Men

    OpenAIRE

    Yoon, Eun Sun; Jung, Su Jin; Cheun, Sung Kun; Oh, Yoo Sung; Kim, Seol Hyang; Jae, Sae Young

    2010-01-01

    Background and Objectives Increased central arterial stiffness is an emerging risk factor for cardiovascular disease. Acute aerobic exercise reduces arterial stiffness, while acute resistance exercise may increase arterial stiffness, but this is not a universal finding. We tested whether an acute resistance exercise program was associated with an increase in arterial stiffness in healthy young men. Subjects and Methods Thirteen healthy subjects were studied under parallel experimental conditi...

  2. Regurgitation in healthy and non healthy infants

    Directory of Open Access Journals (Sweden)

    Cavallo Luciano

    2009-12-01

    Full Text Available Abstract Uncomplicate regurgitation in otherwise healthy infants is not a disease. It consists of milk flow from mouth during or after feeding. Common causes include overfeeding, air swallowed during feeding, crying or coughing; physical exam is normal and weight gain is adequate. History and physical exam are diagnostic, and conservative therapy is recommended. Pathologic gastroesophageal reflux or gastroesophageal reflux disease refers to infants with regurgitation and vomiting associated with poor weight gain, respiratory symptoms, esophagitis. Reflux episodes occur most often during transient relaxations of the lower esophageal sphincter unaccompanied by swallowing, which permit gastric content to flow into the esophagus. A minor proportion of reflux episodes occurs when the lower esophageal sphincter fails to increase pressure during a sudden increase in intraabdominal pressure or when lower esophageal sphincter resting pressure is chronically reduced. Alterations in several protective mechanisms allow physiologic reflux to become gastroesophageal reflux disease; diagnostic approach is both clinical and instrumental: radiological series are useful to exclude anatomic abnormalities; pH-testing evaluates the quantity, frequency and duration of the acid reflux episodes; endoscopy and biopsy are performed in the case of esophagitis. Therapy with H2 receptor antagonists and proton pump inhibitors are suggested.

  3. Invisible Men: Constructing Men Who Have Sex with Men as a Priority at UNAIDS and Beyond

    OpenAIRE

    McKay, Tara

    2013-01-01

    In the last decade, gay men and other men who have sex with men (MSM) have come to the fore of policy debates about AIDS prevention. In stark contrast to global AIDS policy during the first two decades of the epidemic which excluded MSM from policy outside the West, UNAIDS now identifies MSM as "marginalized but not marginal" to the global AIDS epidemic. This dissertation provides an account of this controversial reversal of global AIDS policy and uses it as a point of departure for understan...

  4. Forced circumcision of men (abridged).

    Science.gov (United States)

    Glass, Michael

    2014-08-01

    The forced circumcision of men is a widespread human rights abuse that often accompanies other human rights violations. It occurs in clashes between circumcising and non-circumcising cultures, or when individuals in circumcising cultures reject circumcision. This article documents the forced circumcision of men against their will, shows how evidence of forced circumcision has been downplayed and discounted, and outlines and discusses some measures that could help to reduce its prevalence. PMID:24014634

  5. Aging Men and Prostate Cancer

    Directory of Open Access Journals (Sweden)

    Thompson B

    2015-01-01

    Full Text Available Prostate cancer (PCa is one of the most commonly diagnosed cancers in men worldwide and its incidence increases with age, mainly affecting elderly men aged 60 and above. Factors known to be associated with the development and progression of PCa are age, family history, and race/ethnicity, with age being the most important factor. The reasons for the increased incidence and mortality due to prostate cancer in elderly men are not entirely clear. Continued exposure to environmental and dietary factors may lead to accumulation of genetic and epigenetic changes over the life-span, leading to altered expression and/or activity of tumor promoter and tumor suppressor genes. Changing levels of endogenous hormones (like androgens and metabolism in elderly men may also play a role in the development of prostate cancers which may be further influenced by testosterone replacement therapy. For many decades now preventative strategies and treatments such as radiation therapy or hormone therapy, and others have been administered to manage PCa; however current studies and evidence suggest that PCa is undertreated in elderly men, despite evidence of efficacy of these treatments, which leads to higher prevalence of mortality in this age group. Studies involving basic research, preventative and management strategies are still underway to understand the mechanisms of PCa development in elderly men and treatment of this disease in ageing male population.

  6. Association of late childbearing with healthy longevity among the oldest-old in China

    OpenAIRE

    Yi Zeng; Vaupel, James W.

    2003-01-01

    Statistical analysis of a large and unique longitudinal data set demonstrates that late childbearing after age 35 or 40 is significantly associated with survival and healthy survival among very old Chinese women and men. The association is stronger in oldest-old women than men. The estimates are adjusted for a variety of confounding factors of demographic characteristics, family support, social connections, health practices, and health conditions. Further analysis based on an extension of the...

  7. Vitamin E and C supplementation and risk of cancer in men: posttrial follow-up in the Physicians’ Health Study II randomized trial1234

    OpenAIRE

    Wang, Lu; Sesso, Howard D.; Glynn, Robert J.; Christen, William G.; Bubes, Vadim; Manson, JoAnn E.; Buring, Julie E; Gaziano, J. Michael

    2014-01-01

    Background: Recent posttrial analysis of a completed randomized trial found an increased risk of prostate cancer among healthy men taking high-dose vitamin E supplements. Trials that examined the effect of vitamin C supplements on cancer risk are few.

  8. Healthy Lean Through HRD

    DEFF Research Database (Denmark)

    Jørgensen, Frances

    2008-01-01

    The paper reports on findings from the initial, exploratory phase of a longitudinal research study aimed at developing a framework for implementing lean while ensuring employee well-being. Data from observations and in-depth dialogues with persons involved in lean implementation, along with relev...... relevant theory, are used to construct a tentative framework for implementing "healthy lean". The role of HRD in facilitating implementation of healthy lean is central to the framework, which is presented and discussed.......The paper reports on findings from the initial, exploratory phase of a longitudinal research study aimed at developing a framework for implementing lean while ensuring employee well-being. Data from observations and in-depth dialogues with persons involved in lean implementation, along with...

  9. HEALTHY LIVING WITH NUTRACEUTICALS

    OpenAIRE

    Priyanka Singh; Bina Rani; Chauhan, A. K.; Raaz Maheshwari

    2011-01-01

    Now a day every person wants to live the healthy life. Synthetic medicines are having some certain drawbacks. So nutraceuticals will definitely play promising and unique way of safer medicines. Nature is one of the most important resources of human foods and medicines. Rapidly increasing knowledge on nutrition, medicine, and plant has fortunately changed the concepts about food, health and, brought in a revolution on them. Nutritional therapy and phototherapy have emerged as new concepts of s...

  10. Active Travel - Healthy Lives

    OpenAIRE

    Institute of Public Health in Ireland

    2011-01-01

    Across Ireland, there is considerable scope to replace many short car journeys with walking and cycling which would bring about a range of benefits to health as well as saving money for individuals and society.'Active travel, healthy lives' presents a summary of international evidence on the health and economic benefits of active travel and makes recommendations on how active travel can become a viable, safe and attractive alternative to car use.

  11. Many Healthy Returns

    Centers for Disease Control (CDC) Podcasts

    2010-02-08

    International travel is usually very safe but there are things you should do to stay safe and healthy. Experts show you how to avoid problems when visiting developing nations. This includes being cautious about the food you eat and the water you drink, and to be aware of vehicles and road conditions to prevent problems.  Created: 2/8/2010 by National Center for Emerging and Zoonotic Infectious Disease (NCEZID).   Date Released: 2/8/2010.

  12. Healthy radiation workers

    International Nuclear Information System (INIS)

    A recent study of health records of the workforce at the Lucas Heights Science and Technology Centre, operated by the Australian Nuclear Science and Technology Organisation (ANSTO), has shown that radiation workers have lower mortality rates from all causes and from all cancers than the general population. The Lucas Heights data cover more than 7000 past and present employees, from 1957-1998. This study was part of a research programme being carried out in conjunction with the International Agency for Research on Cancer (IARC) in France and its results add to the much larger pool of data already held by IARC. This finding of the Australian study is similar to the findings of epidemiological studies of the health of workers who have been exposed to low levels of ionising radiation in the course of their occupations elsewhere in the world, and has often been explained as the healthy worker effect. According to this argument, it is reasonable to expect that any group of workers should be more healthy than an average group (with the same age and sex distribution) from the general population. After all, they must at least be healthy enough to get out of bed regularly and go to work. The purpose of the present paper is to ask whether this is the whole story

  13. Temporal discrimination threshold with healthy aging.

    Science.gov (United States)

    Ramos, Vesper Fe Marie Llaneza; Esquenazi, Alina; Villegas, Monica Anne Faye; Wu, Tianxia; Hallett, Mark

    2016-07-01

    The temporal discrimination threshold (TDT) is the shortest interstimulus interval at which a subject can perceive successive stimuli as separate. To investigate the effects of aging on TDT, we studied tactile TDT using the method of limits with 120% of sensory threshold in each hand for each of 100 healthy volunteers, equally divided among men and women, across 10 age groups, from 18 to 79 years. Linear regression analysis showed that age was significantly related to left-hand mean, right-hand mean, and mean of 2 hands with R-square equal to 0.08, 0.164, and 0.132, respectively. Reliability analysis indicated that the 3 measures had fair-to-good reliability (intraclass correlation coefficient: 0.4-0.8). We conclude that TDT is affected by age and has fair-to-good reproducibility using our technique. PMID:27255827

  14. Healthy worker effect

    International Nuclear Information System (INIS)

    Full text: In his letter published in the previous issue of the Journal (pages 71-2), Barrie Skelcher recognises the fact that radiation workers are not a true cross section of the general population because they are selected, and that they have to pass a medical examination. He then infers, despite his own experience of staff recruitment, that it is the medical examination that is responsible 'for weeding out those unfortunate enough to die of cancer in the coming decades'. Typically, the reject percentage from pre-medicals is between 1% and 5%. Thus, in a statistical sense, rejection on medical grounds is unusual, and this concurs with the experience of Barrie Skelcher. One would be rightly sceptical that this in itself could be the explanation for the 'healthy worker effect' so often cited. Though Barrie Skelcher mentions selection he does not consider this aspect further. Three different aspects of the selection process may be considered: (i) self-selection by the employee to apply for work; (ii) employer selection of those that apply; and (iii) selection out of work. An individual will apply for a job that he or she is physically capable of pursuing. As William Ogle observed in 1885, 'Some occupations may repel, while others attract, the unfit at the age of starting work.' Radiation work may repel the unfit; those that apply to work in this industry are self-selected fit. The employer then selects from this self-selected pool of potential recruits. This selection process includes the pre-medical. However, as the pool of recruits are already self-selected fit, the reject percentage is small. Having been selected into the workforce, there is then a selection process that removes people from the workforce. Whilst in employment, the occupational health departments monitor the employees' health. If an individual's health has deteriorated then 'those occupations that attract the unfit' may appear attractive. Others may take ill-health retirement. Workers that remain

  15. Suicide prevention for men - using the internet

    DEFF Research Database (Denmark)

    Anneberg, Inger; Madsen, Bente Hjorth

      In most countries men have a higher suicide rate than women. In Denmark suicide among men is almost three times as frequent as among women. For this reason we wanted to ask the following question: Is there any way to facilitate mens' access to help, when they are in a crisis? Could men be better...

  16. Eat for a Healthy Heart

    Science.gov (United States)

    ... a healthy diet. But with racks full of books and magazines about food and recipes, what is the best diet for a healthy heart? Food and Drug Administration nutrition expert (FDA's) Barbara Schneeman says to follow ...

  17. Overcoming Roadblocks to Healthy Eating

    Science.gov (United States)

    ... Free Stuff Be a Partner Overcoming Roadblocks to Healthy Eating Sometimes it’s hard to make smart food choices . ... from Go4Life to help you overcome barriers to healthy eating . Does food taste different? Your sense of taste ...

  18. Vitamin Supplements: Healthy or Hoax?

    Science.gov (United States)

    ... Recognition & Awards Healthy Workplace Food and Beverage Toolkit Vitamin Supplements: Healthy or Hoax? Updated:Jun 12,2015 Can vitamin and mineral supplements really make you healthier? Overwhelmed ...

  19. Healthy Living Slashes Cancer Risk

    Science.gov (United States)

    ... 2016 THURSDAY, June 23, 2016 (HealthDay News) -- A healthy lifestyle that includes regular exercise and eating nutritiously can ... cancer cases, researchers said. To see whether a healthy lifestyle would result in fewer cancer cases and deaths, ...

  20. Mental health and healthy lifestyle

    OpenAIRE

    Busch, Markus; Hapke, Ulfert; Mensink, Gert

    2011-01-01

    This issue focuses on mental health and the connection with a healthy lifestyle. Data of the German Health Update 2009 (GEDA) show at last that a healthy lifestyle leads to less mental impairments (e.g. depression).

  1. Local administration of growth hormone stimulates tendon collagen synthesis in elderly men

    DEFF Research Database (Denmark)

    Nielsen, Poul Vestergaard; Jørgensen, Jens Otto Lunde; Olesen, Jens L;

    2012-01-01

    Tendon collagen content and circulating growth hormone (GH) are reduced in elderly. In a placebo-controlled, double-blinded study, we examined if local injections of rhGH enhance collagen synthesis in healthy elderly men (61 ± 1 yr). Two injections of rhGH or saline (control) were injected into...

  2. Effect of whole body resistance training on arterial compliance in young men.

    NARCIS (Netherlands)

    Rakobowchuk, M.; McGowan, C.L.; Groot, P.C.E. de; Bruinsma, D.; Hartman, J.W.; Phillips, S.M.; MacDonald, M.J.

    2005-01-01

    The effect of resistance training on arterial stiffening is controversial. We tested the hypothesis that resistance training would not alter central arterial compliance. Young healthy men (age, 23 +/- 3.9 (mean +/- s.e.m.) years; n = 28,) were whole-body resistance trained five times a week for 12 w

  3. Beyond Bad Behaving Brothers: Productive Performances of Masculinities among College Fraternity Men

    Science.gov (United States)

    Harris, Frank, III; Harper, Shaun R.

    2014-01-01

    Research on fraternity men focuses almost exclusively on problematic behaviors such as homophobia and sexism, alcohol abuse, violence against women, sexual promiscuity, and the overrepresentation of members among campus judicial offenders. Consequently, little is known about those who perform masculinities in healthy and productive ways. Presented…

  4. Niche market analysis: healthy nutrition

    OpenAIRE

    Chlivényiová, Eva

    2012-01-01

    The purpose of this Master's Thesis is to consider preferences of the consumers on the market of healthy nutrition and trends on this market. The Thesis analyzes if the niche on the market of healthy nutrition really exists and tries to predict future development of the healthy nutrition through the found out facts. The topic of this Master's Thesis was chosen because healthy lifestyle represents a hot topic for many discussions. This Thesis includes theoretical and analytical parts. Importan...

  5. Dietary patterns and mortality in Danish men and women

    DEFF Research Database (Denmark)

    Osler, M; Heitmann, B L; Gerdes, Lars Ulrik;

    2001-01-01

    The analysis of dietary patterns emerged recently as a possible approach to examining diet-disease relation. We analysed the risk of all-cause and cardiovascular mortality associated with dietary patterns in men and women, while taking a number of potential confounding variables into account. Data...... were from a prospective cohort study with follow-up of total and cause-specific mortality. A random sample of 3698 men and 3618 women aged 30-70 years and living in Copenhagen County, Denmark, were followed from 1982 to 1998 (median 15 years). Three dietary patterns were identified from a twenty......-eight item food frequency questionnaire, collected at baseline: (1) a predefined healthy food index, which reflected daily intakes of fruits, vegetables and wholemeal bread, (2) a prudent and (3) a Western dietary pattern derived by principal component analysis. The prudent pattern was positively associated...

  6. Neurological soft signs in antisocial men and relation with psychopathy.

    Science.gov (United States)

    Demirel, Omer Faruk; Demirel, Aysegul; Kadak, Muhammed Tayyib; Emül, Murat; Duran, Alaattin

    2016-06-30

    Neurological soft signs (NSS) were studied in some axis-I disorders like schizophrenia, obsessive compulsive disorder, bipolar disorder, alcohol and substance abuse disorder. Aim of this study is detection of neurological soft signs in antisocial personality disorder and relation of these signs with psychopathy. The study was included 41 antisocial men and 41 healthy control subjects. Sociodemographic form, neurological evaluation scale and Hare psychopathy checklist was applied to the antisocial subjects, whereas sociodemographic form and neurological evaluation scale were applied to the controls. Antisocial men exhibited significiantly more NSS in total score and subgroups scales (pantisocial group significantly more than controls in our study. Significant relationship between psychopathy and NSS may also hint the role of genetic mechanisms in personality development, though new extended studies with larger sample size are needed for clarification of this relationship. PMID:27131626

  7. PHARMACOTHERAPY ALOPECIA ANDROGENETIC IN MEN

    Directory of Open Access Journals (Sweden)

    Riezky Januar Pramitha

    2013-03-01

    Full Text Available Androgenetic alopecia is hair thinning due to the stimulation of hair follicles to androgens. Incidence in men is higher than in women, it is because men have a degree higher 5? reductase. This condition can cause both physical and psychological effects to the patient. Physical effects due to baldness cause hair loss as a function of protection against heat, cold and trauma. While psychologically can affect self-esteem and self-perception of the patient. Androgenetic alopecia in men influenced by the androgen dihydrotestosterone and genetic predisposition, although the physiology remains unclear. Modality in the management of androgenetic alopecia in males patients including pharmacotherapy, hair transplants and cosmetic approach. According to the Food and Drug Administration (FDA, there are two main drugs are safe and effective in the long term given to men with androgenetic alopecia are minoxidil and finasteride. Although the mechanism of action and route of administration are different, but both drugs have similar effectiveness in stopping the progression of androgenetic alopecia in men.

  8. Dietary Recommendations for Healthy Children

    Science.gov (United States)

    ... Top 10 Tips to Help Children Develop Healthy Habits Fruit and Veggie Toolkit for Kids Healthy Foods Under $1 Per Serving 6 Simple Steps for ... from a cup. Don't overfeed infants and young children — they ... Introduce healthy foods and keep offering them if they're initially ...

  9. Healthy Post-Play Snacks

    Science.gov (United States)

    ... Top 10 Tips to Help Children Develop Healthy Habits Healthy Foods Under $1 Per Serving Mack and Moxy and ... Resources Workplace Health Index Recognition & Awards Healthy Workplace Food and Beverage Toolkit ... Updated:Nov 12,2013 As nearly 1 in 3 kids and teens in the U.S. are overweight or obese, it’s ...

  10. Correlations Between Cardiovascular Autonomic Control Indices During the Two-hour Immobilization Test in Healthy Subjects

    OpenAIRE

    Kiselev, A.R.; V.A. Shvartz; Karavaev, A.S.; Mironov, S. A.; Ponomarenko, V. I.; V.I. Gridnev; M. D. Prokhorov

    2016-01-01

    Objective: The aim of the present study was to assess the features of dynamics of cardiovascular autonomic indices and correlations between them during the two-hour immobilization test in healthy subjects. Methods: Photoplethysmogram (PPG) and electrocardiogram were recorded simultaneously during the two-hour immobilization test in 14 healthy subjects (5 men and 9 women) aged 29±5 years (mean±SD). Dynamics of heart rate variability (HRV) power spectrum in high-frequency and low-frequency rang...

  11. Relationship between Heart Rate Variability, Interleukin-6, and Soluble Tissue Factor in Healthy Subjects

    OpenAIRE

    von Känel, Roland; Nelesen, Richard A.; Mills, Paul J.; Ziegler, Michael G.; Joel E Dimsdale

    2007-01-01

    Decreased heart rate variability (HRV) has been associated with an increased risk of atherosclerosis. We hypothesized that a decrease in frequency domains of resting HRV would be associated with elevated plasma levels of interleukin (IL)-6 and soluble tissue factor (sTF) both previously shown to prospectively predict atherothrombotic events in healthy subjects. Subjects were 102 healthy and unmedicated black and white middle-aged men and women. We determined IL-6 and sTF antigen in plasma and...

  12. Disgust and Sexual Arousal in Young Adult Men and Women.

    Science.gov (United States)

    Grauvogl, Andrea; de Jong, Peter; Peters, Madelon; Evers, Silvia; van Overveld, Mark; van Lankveld, Jacques

    2015-08-01

    Previous research suggested that disgust may interfere with healthy sexual functioning by demonstrating that women with sexual pain disorders are characterized by heightened disgust propensity, relatively strong (physiological and subjective) disgust responses when exposed to sexual stimuli, and relatively strong automatic sex-disgust memory associations. To broaden the understanding of the relationship between sex and disgust, Study 1 tested the relationship between trait disgust and sexual functioning in both men (N = 109) and women (N = 187), and showed that specifically for women both relatively high disgust propensity and high sensitivity were related to lower sexual functioning. Study 2 focused on healthy young adults (N = 19 men and N = 24 women), and tested the relationship between trait disgust and automatic sex-disgust associations as well as the predictive value of trait disgust propensity for participants' level of sexual arousal while watching an erotic video. Participants completed a single-target Implicit Association Task and self-report measures of trait disgust propensity, disgust sensitivity, and sexual functioning. Furthermore, genital and subjective sexual arousal was measured, while participants were watching neutral and erotic video clips. Women showed stronger sex-disgust associations and reported higher disgust propensity than men. Overall, indices of trait disgust and sex-disgust associations were not strongly associated with sexual functioning or sexual arousability. Unexpectedly, specifically in men, high levels of trait disgust sensitivity predicted higher levels of genital and subjective sexual arousal. Overall, no strong evidence was found to support the view that, among young adults without sexual difficulties, high trait disgust or relatively strong automatic sex-disgust associations are associated with low sexual functioning and low sexual arousal. PMID:25231820

  13. Making Healthy Choices Easier

    DEFF Research Database (Denmark)

    Hansen, Pelle Guldborg; Skov, Laurits Rohden; Skov, Katrine Lund

    2016-01-01

    . However, integration and testing of the nudge approach as part of more comprehensive public health strategies aimed at making healthy choices easier is being threatened by inadequate understandings of its scientific character, relationship with regulation and its ethical implications. This article reviews......In recent years the nudge approach to behavior change has emerged from the behavioral sciences to challenge the traditional use of regulation in public health strategies for dealing with modifiable individual level behaviors related to the rise of noncommunicable diseases and their treatment...

  14. Anogenital warts in Danish men who have sex with men

    DEFF Research Database (Denmark)

    Skaaby, Stinna; Kofoed, K

    2011-01-01

    , sociodemographic factors and sexual behaviour conducted in August 2009 in Denmark. Overall 25.2% of the 1184 respondents reported a prior or current episode of AGWs. The prevalence of AGW was significantly higher in homosexuals compared with bisexuals, in men with high levels of education and in those with a high...

  15. Comparative data from young men and women on masseter muscle fibres, function and facial morphology

    DEFF Research Database (Denmark)

    Tuxen, A.; Bakke, M.; Pinholt, E. M.

    1999-01-01

    The primary aim was to relate information about masseter muscle fibres and function to aspects of facial morphology in a group of healthy young men. The secondary aim was to investigate possible sex differences using data previously obtained from a comparable group of age-matched, healthy women....... Dental status and facial morphology were recorded in 13 male students aged 20-26 years. Functional examinations included bite-force measurements and electromyographic recordings of masseter activity. A biopsy was removed from the masseter of each participant during surgical extraction of a wisdom tooth......, and the tissue examined for myosin ATPase activity. Further, the cross-sectional areas of the different fibre types were measured. In spite of using age-matched healthy men and women with a full complement of teeth, statistically significant sex differences were found among measures related to muscle...

  16. Investigation of statistical characteristics of interaction between the low-frequency oscillations in heart rate variability and peripheral microcirculation in healthy subjects and myocardial infarction patients

    OpenAIRE

    Shvartz V.A.; Karavaev A.S.; Borovkova E.l.; Mironov S.A.; Ponomarenko V.I.; Prokhorov M.D.; Butenko A.A.; Gridnev V.I.; Kiselev A.R.

    2015-01-01

    Objective. This study compares the statistical characteristics of interaction between 0.1 Hz oscillations in heart rate variability (HRV) and photoplethysmogram (PPG) in healthy subjects and myocardial infarction (Ml) patients. Material and methods. We studied 23 healthy subjects (20 men and 3 women aged 26±3 years) and 23 patients (12 men and 11 women aged 52±4 years) at about one month after Ml. The 10-minute signals of simultaneously recorded cardioin-tervalogram (CIG) and PPG were studied...

  17. Investigation of statistical characteristics of interaction between the low-frequency oscillations in heart rate variability and photoplethysmographic waveform variability in healthy subjects and myocardial infarction patients

    OpenAIRE

    Vladimir A. Shvartz; Anatoly S. KARAVAEV; Ekaterina I. Borovkova; Sergey A. Mironov; Vladimir I. Ponomarenko; Prokhorov, Mikhail D.; Yurii M. Ishbulatov; Elena E. Lapsheva; Gridnev, Vladimir I.; Kiselev, Anton R.

    2016-01-01

    Objective ― This study compares the statistical characteristics of interaction between 0.1 Hz oscillations in heart rate variability (HRV) and photoplethysmographic waveform variability (PPGV) in healthy subjects and patients with myocardial infarction (MI). Material and Methods ― We studied 23 healthy subjects (20 men and 3 women, aged 26±3 years) and 23 patients (12 men and 11 women, aged 52±4 years) at about one month after MI. The 10-minute signals of simultaneously recorded electrocar...

  18. Sugar-sweetened beverage intake in relation to semen quality and reproductive hormone levels in young men

    DEFF Research Database (Denmark)

    Chiu, Y H; Afeiche, M C; Gaskins, A J;

    2014-01-01

    STUDY QUESTION: Is consumption of sugar-sweetened beverages (SSB) associated with semen quality? SUMMARY ANSWER: Higher consumption of SSB was associated with lower sperm motility among healthy, young men. WHAT IS KNOWN ALREADY: The existing literature on the potential role of SSBs on male...... reproductive function is scarce and primarily focused on the relation between caffeinated beverages and semen quality. However, a rodent model suggests that SSBs may hamper male fertility. STUDY DESIGN, SIZE, DURATION: The Rochester Young Men's Study; a cross-sectional study of 189 healthy young men carried...... out at the University of Rochester during 2009-2010. PARTICIPANTS/MATERIALS, SETTING, METHODS: Men aged 18-22 years provided semen and blood samples, underwent a physical examination and completed a previously validated food frequency questionnaire (FFQ). Linear regression was used to analyze the...

  19. Chronic diseases in elderly men

    DEFF Research Database (Denmark)

    Nielsen, Morten Frost Munk; Wraae, Kristian; Gudex, Claire;

    2012-01-01

    DESIGN AND SETTING: a questionnaire was sent to a random sample of 4,975 men aged 60-74 years. An age-stratified randomised sample (n = 1,845) of those with complete questionnaires was invited to participate in a telephone interview (n = 864), followed by physical examination (n = 600). Self...

  20. Relationship between Anthropometric Factors, Respiratory Exchange Ratio and Energy Expenditure with Maximal Oxygen Uptake among Sedentary Men

    OpenAIRE

    Kamal Ranjbar; Maryam Nourshahi; Meysam Gholamali

    2014-01-01

    Background: Studies reported conflicting results about the relationship between anthropometric factors, respiratory exchange Ratio, energy expenditure and VO2 max. Therefore the aim of this study was to investigate the relationship between anthropometric factors, respiratory exchange ratio and energy expenditure with VO2 max in sedentary men. Materials and Methods: Thirty one sedentary healthy men (23.67±2.45 years old age, BMI=22.49±1.58 kg/m2) volunteered for participation this study. Af...

  1. The role of physical activity and diet on bone mineral indices in young men: a cross-sectional study

    OpenAIRE

    Liberato, Selma C; Bressan, Josefina; Hills, Andrew P.

    2013-01-01

    Background Osteoporotic fractures are a significant cause of morbidity and mortality, particularly in developed countries. Increasing peak bone mass in young people may be the most important primary prevention strategy to reduce the risk of osteoporosis. This study aimed to examine the relationship between dietary factors and physical activity on bone mineralization in young men. Methods Thirty-five healthy men aged 18–25 y had anthropometric measures, body composition, resting metabolic rate...

  2. Smoking as a Confounding Factor on the Influence of Cold Therapy on the Vascular Endothelium Function of Young Men

    OpenAIRE

    Noguchi, Masahiro; Fujikawa, Ryoya; Kimura, Akira

    2013-01-01

    [Purpose] This study was designed to determine whether smoking affects endothelium function after cold therapy in young men. [Subjects] The final cohort included 27 healthy men (age, 20–21 years). Because an impact on vascular endothelium function was anticipated to be caused by smoking, the study enrolled 14 participants in a smoking group and 13 in a non-smoking group. [Methods] Vascular endothelial function was assessed by determining the reactive hyperemia index (RHI), using finger-tonome...

  3. Physical Activity and Cardiovascular Disease Risk Factors Among Young and Middle-Aged men in Urban Mwanza, Tanzania.

    OpenAIRE

    Muhihi, Alfa; Njelekela, Marina; Mpembeni, Rose; Masesa, Zablon; KITAMORI, KAZUYA; Mori, Mari; Kato, Norihiro; Mtabaji, Jacob; Yamori, Yukio

    2012-01-01

    Background Cardiovascular diseases (CVD) risk factors are increasing at an unprecedented rate in developing countries. However, fewer studies have evaluated the role of physical activity in preventing CVD in these countries. We assessed level physical activity and its relationship with CVD risk factors among young and middle aged men in a fast growing city of Mwanza in Tanzania. Methods Physical activity was assessed among 97 healthy men aged 20–50years using Sub-Saharan Africa Activity Quest...

  4. The Effect of Acute Exercise on Serum Vaspin Level and Its Relation to Insulin Sensitivity in Overweight Elderly Men

    OpenAIRE

    Jabbar Bashiri; Adel Rahbaran; Farhad Gholami; Sajad Ahmadizad; Saeid Nikoukheslat; Akram Moradi

    2014-01-01

    Background: Vaspin is a new discovered adipocytokine which is a member of serine protease inhibitor family secreted from adipose tissue and might play a role in insulin sensitivity. The purpose of this study was to investigate the effect of acute exercise on serum vaspin levels and its relation to insulin sensitivity in overweight elderly men. Materials and Methods: In this semi-experimental study, 12 healthy elderly men volunteers randomly selected and performed one session aerobic exerc...

  5. Fucose and Sialic Acid Expressions in Human Seminal Fibronectin and α1-Acid Glycoprotein Associated with Leukocytospermia of Infertile Men

    OpenAIRE

    Kratz, Ewa M.; Ricardo Faundez; Iwona Kątnik-Prastowska

    2011-01-01

    Introduction: The aim of this study was to compare fucose and sialic acid residue expression on fibronectin and α 1-acid glycoprotein in the seminal plasma of men suspected of infertility and suffering from leukocytospermia. Subjects and methods: Seminal ejaculates were collected from 27 leukocytospermic and 18 healthy, normozoospermic men. The relative degree of fucosylation and sialylation of fibronectin and α 1-acid glycoprotein was estimated by ELISA using fucose and sialic acid specific ...

  6. Prevalence of Sarcopenia and Its Relationship with Sites of Fragility Fractures in Elderly Chinese Men and Women

    OpenAIRE

    Wei Hong; Qun Cheng; Xiaoying Zhu; Hanmin Zhu; Huilin Li; Xuemei Zhang; Songbai Zheng; Yanping Du; Wenjing Tang; Sihong Xue; Zhibin Ye

    2015-01-01

    Objective Sarcopenia might be associated with bone fragility in elderly individuals. This study aimed to investigate the prevalence of sarcopenia and its association with fragility fracture sites in elderly Chinese patients. Methods Patients (322 men and 435 women) aged 65–94 years and with a history of fragility fractures in the ankle, wrist, vertebrae or hip, and healthy men (n = 1263) and women (n = 1057) aged 65–92 years without a history of fractures were enrolled. Whole-body dual energy...

  7. Healthy Hair Starts With a Healthy Body: Hair Stylists as Lay Health Advisors to Prevent Chronic Kidney Disease

    Directory of Open Access Journals (Sweden)

    Mary E. Madigan

    2007-07-01

    Full Text Available Background Chronic kidney disease affects one in nine Americans. Diabetes and hypertension account for nearly three quarters of all kidney failure cases. Disproportionate rates of chronic kidney disease, diabetes, and hypertension have been observed among African Americans. More than 70% of all kidney failure cases caused by diabetes and hypertension could have been prevented or delayed with healthy lifestyles and medications.Context Approximately 14% of the population living in Michigan is African American. Despite this small proportion, 47% of patients on dialysis and 45% of those on the kidney transplant waiting list are African American. Risk of end-stage kidney failure is 4 times greater among African Americans than among whites.Methods The National Kidney Foundation of Michigan developed the Healthy Hair Starts with a Healthy Body (Healthy Hair campaign to educate African American men and women about their disease risks and to motivate prevention behaviors. The campaign trains African American hair stylists to promote healthy behaviors with their clients through a “health chat” and by providing diabetes and hypertension risk assessment information and incentives.Consequences Since 1999, Healthy Hair has trained nearly 700 stylists and reached more than 14,000 clients in eight Michigan cities. Information collected through a client “Chat Form” suggests a number of positive behavioral results.Interpretation With nearly 60% of clients indicating that they have taken steps to prevent diabetes, hypertension, and chronic kidney disease or to seek a physician’s advice, the Healthy Hair program appears to be effective in the short term in prompting attention to healthy behaviors and increasing risk awareness.

  8. Suplementação proteica não aumenta a concentração plasmática de óxido nítrico em homens saudáveis Protein supplementation does not increase nitric oxide plasmatic concentration in healthy men

    Directory of Open Access Journals (Sweden)

    Milton Rocha de Moraes

    2009-04-01

    Full Text Available Suplementos nutricionais, supostamente, capazes de potencializar a produção endógena de óxido nítrico (NO têm experimentado crescente popularidade entre os indivíduos fisicamente ativos. Diante da carência de informações sobre o assunto, o objetivo do presente estudo foi avaliar o efeito de um suplemento comercial à base de proteínas e aminoácidos sobre a produção endógena de NO. MÉTODOS: A amostra foi constituída de 12 homens sedentários, mas sem fatores de risco para doenças cardiovasculares. O protocolo de suplementação foi conduzido conforme o arranjo experimental duplo-cego cruzado. Os participantes receberam, aleatoriamente, placebo (PLA ou suplemento proteico (SP, em dois momentos diferentes, separados por uma semana. Com o intuito de determinar a concentração plasmática de NO, amostras de sangue foram coletadas antes (24h e imediatamente antes e depois (30 e 60 minutos do consumo da substância PLA ou do SP. RESULTADOS: Não foi observada alteração na concentração plasmática de NO após a ingestão do SP em comparação com o PLA (pós-suplementação 30min - PLA: 19,3 ± 4,7µmol.L- 1 vs. SP: 18,9 ± 4,4µmol.L-1 e pós-suplementação 60min - PLA: 21,3 ± 6,5µmol.L-1 vs. SP: 20,3 ± 4,9µmol.L-1. Também não foi verificada alteração da pressão arterial. CONCLUSÃO: O suplemento nutricional à base de proteínas e aminoácidos, testado no presente estudo, não potencializou a produção endógena de NO.Nutritional supplements, theoretically able to increase endogenous nitric oxide (NO production have experienced great popularity among physically active individuals. AIM: scientific evidence available regarding this issue is scarce. Therefore, the purpose of this study was to evaluate the effect of a dietary supplement commercialized as a nitric oxide booster. MATERIALS AND METHODS: twelve sedentary men with no risk factors for cardiovascular diseases were supplemented with placebo or protein in two

  9. Working through resistance in engaging boys and men towards gender equality and progressive masculinities.

    Science.gov (United States)

    Ratele, Kopano

    2015-01-01

    Over the last two decades, a focus on challenging and transforming dominant forms of masculinity and engaging boys and men towards gender equality and healthy masculinities has permeated South African social and health sciences and the humanities. This focus on men and boys has also been evident in intervention and activist work. However, the turn to boys, men and masculinities has not gone without resistance, contestation and contradictions. A range of localised and global realities has frustrated much of the enthusiasm for rapid, sweeping and concrete changes regarding gender justice and the making of progressive masculinities. Among the discursive and material forces that oppose work that engages boys and men are those to do with income-related issues, race and racism, cultural traditions and gender itself. Because of this, it is contended that engagement with boys and men needs to consider not only gender but also economic inequality, poverty and unemployment, divisions created by race, and struggles around tradition. This paper discusses these forces that undermine and counteract work with boys and men and how we might work through resistance in engaging with men and boys. PMID:26073936

  10. Comparison of Plasma Neurosteroid and Prolactin Levels in Patients with Schizophrenia and Healthy Individuals

    Directory of Open Access Journals (Sweden)

    Forough Riahi

    2016-01-01

    Full Text Available Background. The present study aimed to compare plasma levels of cortisol, testosterone, dehydroepiandrosterone (DHEA, and prolactin in patients with schizophrenia and healthy individuals. Method. A total of 100 patients with schizophrenia disorder (69 men and 31 women and 190 healthy individuals (94 men and 96 women participated in this cross-sectional study. They were tested for hormone levels and completed demographic questionnaires. Data were analyzed using multivariate analysis of variance (MANOVA and one-way analysis of variance. Results. Serum testosterone level was significantly higher in men with schizophrenia than in healthy men. Women with schizophrenia had a significantly higher level of testosterone and lower level of prolactin compared to healthy women. There were no significant differences in hormone levels across various subtypes of schizophrenia. No significant differences also were observed in hormones levels in patients with first-episode schizophrenia disorder compared to those in patients with recurrent episodes. Conclusion. This study indicated that abnormal testosterone and prolactin levels might be associated with pathophysiology of schizophrenia disorder.

  11. Comparison of Plasma Neurosteroid and Prolactin Levels in Patients with Schizophrenia and Healthy Individuals.

    Science.gov (United States)

    Riahi, Forough; Izadi-Mazidi, Maryam; Ghaffari, Ali; Yousefi, Elham; Khademvatan, Shahram

    2016-01-01

    Background. The present study aimed to compare plasma levels of cortisol, testosterone, dehydroepiandrosterone (DHEA), and prolactin in patients with schizophrenia and healthy individuals. Method. A total of 100 patients with schizophrenia disorder (69 men and 31 women) and 190 healthy individuals (94 men and 96 women) participated in this cross-sectional study. They were tested for hormone levels and completed demographic questionnaires. Data were analyzed using multivariate analysis of variance (MANOVA) and one-way analysis of variance. Results. Serum testosterone level was significantly higher in men with schizophrenia than in healthy men. Women with schizophrenia had a significantly higher level of testosterone and lower level of prolactin compared to healthy women. There were no significant differences in hormone levels across various subtypes of schizophrenia. No significant differences also were observed in hormones levels in patients with first-episode schizophrenia disorder compared to those in patients with recurrent episodes. Conclusion. This study indicated that abnormal testosterone and prolactin levels might be associated with pathophysiology of schizophrenia disorder. PMID:27293968

  12. Motor performance during and following acute alcohol intoxication in healthy non-alcoholic subjects

    DEFF Research Database (Denmark)

    Poulsen, Mette Buch; Jakobsen, Johannes Klitgaard; Andersen, Henning;

    2007-01-01

    Chronic alcohol abuse has adverse effects on skeletal muscle, and reduced muscle strength is frequently seen in chronic alcoholics. In this study the acute effects of moderate alcohol intoxication on motor performance was evaluated in 19 non-alcoholic healthy subjects (10 women, 9 men). A...

  13. Gender differences in the associations between cortisol and insulin in healthy subjects

    NARCIS (Netherlands)

    Stolk, RP; Lamberts, SWJ; deJong, FH; Pols, HAP; Grobbee, DE

    1996-01-01

    To investigate the role of cortisol in the etiology of insulin resistance in men and women, we examined 218 healthy non-hospitalized elderly, selected from the Rotterdam Study. Free cortisol was assessed by the ratio of fasting serum cortisol over corticosteroid-binding globulin (CBG), and insulin r

  14. Lung Volume during Swallowing: Single Bolus Swallows in Healthy Young Adults

    Science.gov (United States)

    Hegland, Karen M. Wheeler; Huber, Jessica E.; Pitts, Teresa; Sapienza, Christine M.

    2009-01-01

    Purpose: This study examined the relationship between swallowing and lung volume initiation in healthy adults during single swallows of boluses differing in volume and consistency. Differences in lung volume according to respiratory phase surrounding the swallow were also assessed. Method: Nine men and 11 women between the ages of 19 and 28 years…

  15. Comparative optimism about healthy eating

    OpenAIRE

    Sproesser, Gudrun; Klusmann, Verena; Schupp, Harald T.; Renner, Britta

    2015-01-01

    The present study investigated people's perception of their own as compared to their peers' healthy eating and related these perceptions to actual healthy eating, BMI, and subsequent healthy eating behavior. Data were collected within the framework of the longitudinal cohort study Konstanz Life Study (T1: N = 770; T2: N = 510). Our results demonstrated an optimistic bias on the group level. Specifically, people rated their own eating behavior as healthier on average than that of their average...

  16. Hormone Therapy for Breast Cancer in Men

    Science.gov (United States)

    ... Topic Targeted therapy for breast cancer in men Hormone therapy for breast cancer in men Hormone therapy ... fatigue, and pain at the injection site. Luteinizing hormone-releasing hormone (LHRH) analogs and anti-androgens LHRH ...

  17. Many Men Have Body Image Issues, Too

    Science.gov (United States)

    ... journal Psychology of Men & Masculinity . Gender differences in "body dissatisfaction" are shrinking, likely because of media influence, said ... at higher risk than straight men for developing body dissatisfaction. But those studies were based on small, biased ...

  18. Consumer perceptions of beef healthiness

    DEFF Research Database (Denmark)

    Van Wezemael, Lynn; Verbeke, Wim; Dutra de Barcellos, Marcia;

    2010-01-01

    BACKGROUND: Consumer perception of the healthiness of beef is an important determinant of beef consumption. However, little is known about how consumers perceive the healthiness of beef. The aim of this study is to shed light on the associations between beef and health. METHODS: Eight focus group...... correct judgements about how healthful their food is. However, the results of this study indicate that an accurate assessment of beef healthiness is not always straightforward. The presented results on consumer perceptions of beef healthiness provide insights into consumer decision making processes, which...

  19. Androgen deficiency and aging in men.

    OpenAIRE

    Swerdloff, R S; Wang, C

    1993-01-01

    Androgen levels decrease with age in men. Androgen deficiency in men older than 65 years leads to asthenia, a decrease in muscle mass, osteoporosis, and a decrease in sexual activity. Androgen deficiency has been reported to cause changes in mood and cognitive function. The combination of these factors results in impaired quality of life in older men. Androgen replacement therapy in hypogonadal men increases bone and muscle mass, enhances muscle and cardiovascular function, and improves sexua...

  20. Predictors of HIV Sexual Risk Behavior among Men Who Have Sex with Men, Men Who Have Sex with Men and Women, and Transgender Women

    OpenAIRE

    Bowers, Jane Rohde; Branson, Catherine M.; Jesse B. Fletcher; Reback, Cathy J.

    2012-01-01

    Men who have sex with men, men who have sex with men and women, and transgender women are at high risk for HIV infection. This study seeks to clarify which known HIV risk factors (partner type, sex location, serodiscordance, multiple sex partners, substance use during sex) contribute to engagement in high-risk (unprotected receptive anal) sex in each population. Data collected from June 2005 through June 2008 indicate all three populations display different HIV sexual risk profiles. The data ...

  1. Osteoporosis in Men: Insights for the Clinician

    OpenAIRE

    Adler, Robert A.

    2011-01-01

    Osteoporosis has finally been recognized as an important disorder in men. Men have osteoporotic fractures about 10 years later in life than women. Owing to increasing life expectancy, more fractures are predicted. Important risk factors for men include advancing age, smoking or chronic obstructive pulmonary disease, glucocorticoid therapy, and androgen deprivation therapy for prostate cancer. Other groups at risk for osteoporosis include those with alcohol abuse, men on enzyme-inducing antise...

  2. ADRB3 Polymorphism Associated with BMI Gain in Japanese Men

    Directory of Open Access Journals (Sweden)

    Shouhei Takeuchi

    2012-01-01

    Full Text Available Objective. The aim of this study was to evaluate the association between the Trp64Arg polymorphism in the beta3-adrenergic receptor gene (ADRB3: rs4994 and BMI and serological and anthropometric data in healthy Japanese. Methods. Healthy Japanese recruited in a large-scale integrated manufacturing facility in Japan (=1355; age: 37.25 ± 9.43; BMI: 22.86 ± 3.46 were eligible for analysis. The anthropometric data and serological data were measured during a comprehensive health check, and a self-reporting questionnaire was used to assess lifestyle habits (current exercise, smoking status, alcohol intake, and working style and weight at age 20. Genotyping for the ADRB3 polymorphism was performed by PCR-RFLP method. Results. Among 1355 participants, the genotype frequencies of the Trp/Trp, Trp/Arg, and Arg/Arg variants were 920 (67.9%, 394 (29.1%, and 41 (3.05%, respectively. In the multivariate analysis, a multiple linear regression model in men for the adjustment of age, drinking habits, smoking habits, exercise habits, working status and serological measurements statistically showed an overall weak significance between annual BMI gain from age 20 and age, LDL or ADRB3 polymorphism. Conclusions. The level of LDL, age, and ADRB3 polymorphism (Arg/Arg genotype were statistically associated with annual BMI gain in Japanese men.

  3. Adolescents' Perceptions of Healthy Eating and Communication about Healthy Eating

    Science.gov (United States)

    Chan, Kara; Prendergast, Gerard; Gronhoj, Alice; Bech-Larsen, Tino

    2009-01-01

    Purpose: The purpose of this paper is to explore Chinese adolescents' perceptions of healthy eating, their perceptions of various socializing agents shaping their eating habits, and their opinions about various regulatory measures which might be imposed to encourage healthy eating. Design/methodology/approach: Four focus group interview sessions…

  4. Serum inhibin B in healthy pubertal and adolescent boys

    DEFF Research Database (Denmark)

    Andersson, A M; Juul, A; Petersen, J H;

    1997-01-01

    Inhibin B levels were measured in serum from 400 healthy Danish prepubertal, pubertal, and adolescent males, aged 6-20 yr, in a cross-sectional study using a recently developed immunoassay that is specific for inhibin B, the physiologically important inhibin form in men. In addition, serum levels...... inhibin B to FSH, LH, and testosterone changes during pubertal development. Early puberty is characterized by a positive correlation between inhibin B and LH/testosterone, but no correlation to FSH. Late puberty (from stage III) is characterized by a negative correlation between inhibin B and FSH (which...... is maintained in adult men), a diminishing negative correlation between inhibin B and LH, and no correlation between inhibin B and testosterone, suggesting that developmental and maturational processes in the hypothalamic-pituitary-gonadal axis take place, leading to the establishment of the closed...

  5. Fatherhood and Men's Lives at Middle Age

    Science.gov (United States)

    Eggebeen, David J.; Dew, Jeffrey; Knoester, Chris

    2010-01-01

    This article uses data on 2,024 men who were followed through the third wave of the National Survey of Families and Households to examine the implications of fatherhood experiences for men's involvement in altruistic social activities at middle age. We find that middle-aged men (ages 45-65) who at some point in their lives become fathers are…

  6. Stereotypes of Older Lesbians and Gay Men

    Science.gov (United States)

    Wright, Sara L.; Canetto, Silvia Sara

    2009-01-01

    This study examined stereotypes of older lesbians and gay men. Key findings are that older lesbians and gay men were perceived as similar to older heterosexual women and men with regard to aging stereotypes, such as being judicious. At the same time, sexual minorities were targets of unique stereotypes. Consistent with the implicit inversion…

  7. Preexposure Prophylaxis and Patient Centeredness: A Call for Holistically Protecting and Promoting the Health of Gay Men.

    Science.gov (United States)

    Snowden, Jonathan M; Rodriguez, Maria I; Jackson, Skyler D; Marcus, Julia L

    2016-09-01

    Preexposure prophylaxis has transformed HIV prevention, becoming widespread in communities of gay and bisexual men in the developed world in a short time. There is a broad concern that preexposure prophylaxis will discourage condom use among gay men (i.e., "risk compensation"). This commentary argues for broadening the focus on gay men's health beyond sexual health to address the holistic health and well-being of gay men. Gay men may benefit from being offered candid, nonjudgmental health promotion/HIV prevention messages not requiring condom use for anal sex. Lessons can be drawn from the family planning movement, which has undergone a similar shift in focus. The principle of patient centeredness supports such a shift in gay men's health toward the goal of providing men with the knowledge to evaluate various prevention approaches according to the specifics of their life circumstances and health needs. Bringing more nuance to discussions of sexual risk and sexual pleasure could facilitate more universally healthy attitudes regarding sex among gay men, in turn enabling healthier decisions more compatible with men's own values and preferences. PMID:27387042

  8. Are urine flow-volume nomograms developed on Caucasian men optimally applicable for Indian men? Need for appraisal of flow-volume relations in local population

    OpenAIRE

    Agarwal, Mayank M.; Choudhury, Sunirmal; Mandal, Arup K.; Mavuduru, Ravimohan; Singh, Shrawan K.

    2010-01-01

    Introduction: Flow-volume nomograms and volume-corrected flow-rates (cQ) are tools to correct uroflow rates (Q) with varied voided volumes (VV) of urine. We investigated the applicability of the available nomograms in our local population. Materials and Methods: Raw data of our previous study on variation in Q with voiding position (standing, sitting, and squatting) in healthy adult men was reanalyzed. Additionally, the departmental urodynamic database of the last four years was searched for ...

  9. HEALTHY LIVING WITH NUTRACEUTICALS

    Directory of Open Access Journals (Sweden)

    Priyanka Singh

    2011-12-01

    Full Text Available Now a day every person wants to live the healthy life. Synthetic medicines are having some certain drawbacks. So nutraceuticals will definitely play promising and unique way of safer medicines. Nature is one of the most important resources of human foods and medicines. Rapidly increasing knowledge on nutrition, medicine, and plant has fortunately changed the concepts about food, health and, brought in a revolution on them. Nutritional therapy and phototherapy have emerged as new concepts of safer medicine. These systems have quickly and widely spread in recent years. Strong recommendations for consumption of nutraceuticals, natural plant foods, and the use of nutritional therapy and phototherapy have become progressively popular to improve health, and to prevent and treat diseases. Nutraceuticals used in various diseases, Alzheimer’s disease, cardiovascular disease, obesity, cancer, eye cycle, diabetes. The use of the dietary fiber, omega 3 fatty acid, antioxidant, probiotic, for the better human life possible. This review attempts to display and remark on these aspects. It summarizes the progress made on nutraceuticals, utritional therapy, health benefits, regulation and their promising approach. It also covers development stages of nutraceuticals.

  10. A Men's Workplace Health Intervention

    Science.gov (United States)

    Johnson, Steven T.; Stolp, Sean; Seaton, Cherisse; Sharp, Paul; Caperchione, Cristina M.; Bottorff, Joan L.; Oliffe, John L.; Jones-Bricker, Margaret; Lamont, Sonia; Medhurst, Kerensa; Errey, Sally; Healy, Theresa

    2016-01-01

    Objective: To explore physical activity and eating behaviors among men following the implementation of a gender-sensitive, workplace health promotion program. Methods: Using a pre-post within-subjects design, computer-assisted telephone interviewing (CATI) was used to collect health-related information along with physical activity and fruit/vegetable intake at baseline and after 6 months. Results: At baseline, participants (N = 139) consumed 3.58 servings of fruit and vegetables/day and engaged in an average of 229.77 min/week moderate-vigorous physical activity (MVPA). At 6 months, daily fruit/vegetable intake did not increase, whereas MVPA increased by 112.3 min/week. Conclusions: The POWERPLAY program successfully increased weekly MVPA. Engaging men in health promotion can be a challenge; here, the workplace served as a valuable environment for achieving positive change. PMID:27281710

  11. Masculinity and food ideals of men who live alone.

    Science.gov (United States)

    Sellaeg, Kari; Chapman, Gwen E

    2008-07-01

    Most studies of social aspects of foods have focused on people in multi-person households, often from the perspective of women. Little is known about the food-related experiences of men who live alone. We therefore conducted a qualitative study with 12 men aged 27-47 who lived alone in Vancouver, Canada. Our goals were to explore their food-related ideals, and their perceptions of how those ideals relate to their actual food practices, the context of living alone, and masculine identities. Data were collected through food journals and semi-structured interviews. The men's ideals included being conscious and organized with respect to food so that they could regularly eat meals prepared at home from healthy ingredients. Eating with others was considered an ideal food context, where the meal became an "occasion", as opposed to "just eating". Participants believed that their eating habits often did not live up to these ideals because of lack of time and because the context of living alone was not conducive to eating well. However, they thought their habits were better than what they perceived to be the habits of a stereotypical bachelor who does not know how to cook and has a 'who cares' attitude towards food. PMID:18343534

  12. Fairness ja tak - men hvordan?

    DEFF Research Database (Denmark)

    Lyngbye, Lise

    2008-01-01

    Journalistik skal være fair - vi hører og læser det igen og igen i skåltaler og debatindlæg. Men hvad betyder det lille ord fair egentlig, når vi snakker journalistik? Er det en floskel at hævde, at journalistik skal være fair? Eller ligger der gemt i ordet nole journalistiske dyder, som vi skal...

  13. Executive functions in elderly men

    OpenAIRE

    Liu, Mu-En; Chang, Yun-Hsuan; Ku, Yan-Chiou; Lee, Sheng-Yu; Huang, Chih-Chung; Chen, Shiou-Lan; Chen, Shih-Heng; Chu, Chun-Hsien; Liu, Wen-Chien; Lu, Ru-Band

    2011-01-01

    The executive function deficit is greater in depressed patients with cardiovascular disease than in depressed patients without cardiovascular disease. Late-life depression is said to have a vascular etiology and would worsen the executive function. A cross-sectional design was used for this study. The study was done in outpatient clinics of Kaohsiung Veterans General Hospital and National Cheng Kung University Hospital, Taiwan. Three hundred thirty-five older elderly men (>75 years old) were ...

  14. Effects of Growth Hormone Administration on Muscle Strength in Men over 50 Years Old

    Directory of Open Access Journals (Sweden)

    A. B. W. Tavares

    2013-01-01

    Full Text Available Growth hormone (GH use has been speculated to improve physical capacity in subjects without GH deficiency (GHD through stimulation of collagen synthesis in the tendon and skeletal muscle, which leads to better exercise training and increased muscle strength. In this context, the use of GH in healthy elderly should be an option for increasing muscle strength. Our aim was to evaluate the effect of GH therapy on muscle strength in healthy men over 50 years old. Fourteen healthy men aged 50–70 years were evaluated at baseline for body composition and muscle strength (evaluated by leg press and bench press exercises, which focus primarily on quadriceps—lower body part and pectoralis major—upper body part—muscles, resp.. Subjects were randomised into 2 groups: GH therapy (7 subjects and placebo (7 subjects and reevaluated after 6 months of therapy. Thirteen subjects completed the study (6 subjects in the placebo group and 7 subjects in the GH group. Subjects of both groups were not different at baseline. After 6 months of therapy, muscle strength in the bench press responsive muscles did not increase in both groups and showed a statistically significant increase in the leg press responsive muscles in the GH group. Our study demonstrated an increase in muscle strength in the lower body part after GH therapy in healthy men. This finding must be considered and tested in frail older populations, whose physical incapacity is primarily caused by proximal muscle weakness. The trial was registered with NCT01853566.

  15. What Does "Healthy Eating" Mean?

    Science.gov (United States)

    ... Get Free Stuff Be a Partner What Does “Healthy Eating” Mean? According to the Dietary Guidelines for Americans , ... help, too! Download the Tip Sheet What Does “Healthy Eating” Mean? (PDF, 513.2 KB) You Might Also ...

  16. Healthy Eating and Academic Achievement

    Centers for Disease Control (CDC) Podcasts

    2014-12-09

    This podcast highlights the evidence that supports the link between healthy eating and improved academic achievement. It also identifies a few actions to support a healthy school nutrition environment to improve academic achievement.  Created: 12/9/2014 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 12/9/2014.

  17. Prepare Healthy Foods with Toddlers

    Science.gov (United States)

    Izumi-Taylor, Satomi; Rike, Cheryl

    2011-01-01

    Toddlers--from about 16 to 36 months--can learn a variety of skills as they prepare food and follow recipes in developmentally appropriate ways. Early childhood teachers are encouraged to support young children's healthy eating habits by offering simple food preparation experiences. When toddlers--and preschoolers--safely prepare healthy snacks,…

  18. Healthy lifestyle and Czech consumers

    OpenAIRE

    Kubešová, Jana

    2011-01-01

    This thesis is focused on healthy lifestyle. It concentrates specifically on impact on human health and which lifestyle lives Czech population. This work summarizes the principles of helathy lifestyle and reveals lifestyles of Czech people with market segmentation and MML-TGI data in the practical part. This can help firms in targeting and addressing people within healthy lifestyle.

  19. The andrologist's contribution to a better life for ageing men: part 2.

    Science.gov (United States)

    Comhaire, F; Mahmoud, A

    2016-02-01

    The long-term intake of a judiciously composed nutriceutical containing low-dose vitamins, antioxidants, minerals and particular herbal preparations seems justified for older persons who take medication, or who consume an unbalanced diet, or who are exposed to environmental toxins. Recent reports suggest these nutriceuticals may delay age-related diseases and the occurrence of cancer, and reduce mortality in apparently healthy ageing men. Food supplementation with a nutriceutical that was formulated particularly for ageing men should result in an increase of at least one quality-adjusted life year and may lower the financial and social burden of disease in elderly people. PMID:26395368

  20. CHANGES OF SELECTED PHYSIOLOGICAL INDICES IN MEN UNDER THE INFLUENCE OF THERMAL HEATING AND COOLING

    Directory of Open Access Journals (Sweden)

    Prystupa Tetyana

    2010-01-01

    Full Text Available The research objective is defining the influence of exposure to heat during the Finnish sauna treatment in the morning hours on selected physiological indices in men, who were monitored during a series of three sauna treatments in a row. 74 healthy men took part in the studies. Body weight and its composition was diagnosed with the help of TANITA BODY COMPOSITION ANALYZER TBF-300 based on bioelectrical impedance analysis. The conducted research confirm the hypothesis about the positive effect of the Finnish sauna on the body mass components, such as body mass, BMI, TBW (kg and % body fat.

  1. Insulin secretion and cellular glucose metabolism after prolonged low-grade intralipid infusion in young men

    DEFF Research Database (Denmark)

    Jensen, Christine B; Storgaard, Heidi; Holst, Jens Juul; Dela, Flemming; Madsbad, Sten; Vaag, Allan A

    2003-01-01

    not in the nonoxidative) glucose metabolism in young healthy men. Moreover, insulin hypersecretion perfectly countered the free-fatty acid-induced insulin resistance. Future studies are needed to determine the role of a prolonged moderate lipid load in subjects at increased risk of developing diabetes.......We examined the simultaneous effects of a 24-h low-grade Intralipid infusion on peripheral glucose disposal, intracellular glucose partitioning and insulin secretion rates in twenty young men, by 2-step hyperinsulinemic euglycemic clamp [low insulin clamp (LI), 10 mU/m(2) x min; high insulin clamp...

  2. Determinants of selenium status in healthy adults

    Directory of Open Access Journals (Sweden)

    Hoeg Antonia

    2011-07-01

    Full Text Available Abstract Background Selenium (Se status in non-deficient subjects is typically assessed by the Se contents of plasma/serum. That pool comprises two functional, specific selenoprotein components and at least one non-functional, non-specific components which respond differently to changes in Se intake. A more informative means of characterizing Se status in non-deficient individuals is needed. Methods Multiple biomarkers of Se status (plasma Se, serum selenoprotein P [SEPP1], plasma glutathione peroxidase activity [GPX3], buccal cell Se, urinary Se were evaluated in relation to selenoprotein genotypes (GPX1, GPX3, SEPP1, SEP15, dietary Se intake, and parameters of single-carbon metabolism in a cohort of healthy, non-Se-deficient men (n = 106 and women (n = 155. Conclusions Plasma Se concentration was 142.0 ± 23.5 ng/ml, with GPX3 and serum-derived SEPP1 calculated to comprise 20% and 34%, respectively, of that total. The balance, comprised of non-specific components, accounted for virtually all of the interindividual variation in total plasma Se. Buccal cell Se was associated with age and plasma homocysteine (hCys, but not plasma Se. SEPP1 showed a quadratic relationship with body mass index, peaking at BMI 25-30. Urinary Se was greater in women than men, and was associated with metabolic body weight (kg0.75, plasma folate, vitamin B12 and hCys (negatively. One GPX1 genotype (679T/T was associated with significantly lower plasma Se levels than other allelic variants. Selenium intake, estimated from food frequency questionnaires, did not predict Se status as indicated by any biomarker. These results show that genotype, methyl-group status and BMI contribute to variation in Se biomarkers in Se-adequate individuals.

  3. Men

    Science.gov (United States)

    > Find Us On Facebook Twitter Pinterest Youtube Instagram Diabetes Stops Here Blog Online Community Site Menu Are You at Risk? Diagnosis Lower Your Risk Risk Test Alert Day Prediabetes My Health Advisor Tools to ...

  4. European experience of HIV prevention policy among men who have sex with men

    Directory of Open Access Journals (Sweden)

    Klymenko, Nadiia

    2012-07-01

    Full Text Available BACKGROUND: Men who have sex with men (MSM are a high-risk group for HIV. Implementation of effective preventive activities is an important way to combat HIV among MSM. However, in Ukraine there is no real HIV prevention policy among MSM and the need for its formulation is still open. MATERIAL AND METHODS: Analysis of legal acts, national reports and other official documents related to HIV prevention among MSM was carried out for Romania, Slovenia, the Netherlands, and Sweden.RESULTS: European countries use various approaches to HIV prevention among MSM: institutional, structural, and media approach.Countries under consideration have fully specified the minimum standard package for HIV prevention among MSM, who are defined as the highest priority group. Distinct strategies for MSM and ways to achieve them are outlined within the national plans and strategies for combating HIV/AIDS (Slovenia, Romania, the Netherlands. The National plan for HIV prevention among MSM will come into action in 2012 in Sweden. Countries, chosen for this study, use the principle of social contract by which the government provides subsidies and grants to nongovernmental organizations (NGOs working with MSM through its specialized health care units (Slovenia, Sweden, and sometimes only for one national NGO (the Netherlands. Outreach is the most common model of NGO’s activities.. In Sweden, MSM can get counseling and HIV testing in specialized HIV clinic for MSM. HIV prevention among MSM is run by representatives of NGOs through dating sites (Slovenia, Romania, through educating MSM and further promotion of healthy lifestyles among their friends. Along with the behavior modification activities, anti-discrimination strategies are used (Sweden, the Netherlands, Slovenia.CONCLUSIONS: Review of the regulatory frameworks, empowerment of NGOs, implementation of the social contract mechanisms, using interactive tools and providing education for MSM can be key points of HIV

  5. Diurnal changes of biochemical metabolic markers in healthy young males

    DEFF Research Database (Denmark)

    Sennels, Henriette P; Jørgensen, Henrik L; Fahrenkrug, Jan

    2015-01-01

    .06 mmol/L) did not show significant oscillations. CONCLUSIONS: When diagnosing and monitoring metabolic disorders compensation for the 24-h variation of the biochemical metabolic markers is needed especially C-peptide, triglyceride and glucose. Furthermore, the stable HbA1c level through 24 h makes......BACKGROUND: To examine whether time of the day has an effect on the circulating levels of metabolism parameters. METHODS: Venous blood samples were obtained under standardized conditions from 24 healthy young men every third hour through 24 hours. The metabolic markers and melatonin were examined...

  6. Licorice consumption and serum testosterone in healthy man.

    Science.gov (United States)

    Armanini, D; Bonanni, G; Mattarello, M J; Fiore, C; Sartorato, P; Palermo, M

    2003-09-01

    We have previously found that licorice can reduce serum testosterone in healthy men. These results were not confirmed in another study, where the same amounts of licorice did not decrease salivary testosterone values. In the actual study we treated more cases with the same amount of licorice and reproduced our previous data. The mean testosterone values decreased by 26 % after one week of treatment (p < 0.01). There was also a significant increase in 17-OHP and LH concentrations and a slight, but not significant decrease in free testosterone. Licorice treatment, in addition, did not affect the response of testosterone and 17-OHP to stimulation with beta-HCG. PMID:14520600

  7. Trends in healthy life expectancy in Japan: 1986 - 2004

    OpenAIRE

    Vanessa Yong; Yasuhiko Saito

    2009-01-01

    This article examines the increasing life expectancy of Japanese men and women in relation to their health from 1986 to 2004. We computed healthy life expectancy for seven available time-points using the prevalence-based Sullivan method. The results showed that, for both sexes and at all ages, the gains in life expectancy prior to 1995 were mostly in years of good self-rated health, while the gains thereafter were in years of poor self-rated health. The exception was for women at age 85, amon...

  8. Systemic inflammation in 222.841 healthy employed smokers and nonsmokers: white blood cell count and relationship to spirometry

    OpenAIRE

    Fernández José Antonio; Prats Josép; Artero José Vicente; Mora Alberto; Fariñas Anna; Espinal Anna; Méndez José Antonio

    2012-01-01

    Abstract Background Smoking has been linked to low-grade systemic inflammation, a known risk factor for disease. This state is reflected in elevated white blood cell (WBC) count. Objective We analyzed the relationship between WBC count and smoking in healthy men and women across several age ranges who underwent preventive medical check-ups in the workplace. We also analysed the relationship between smoking and lung function. Methods Cross-sectional descriptive study in 163 459 men and 59 382 ...

  9. The acquired immunodeficiency syndrome in gay men.

    Science.gov (United States)

    Jaffe, H W; Hardy, A M; Morgan, W M; Darrow, W W

    1985-11-01

    The acquired immunodeficiency syndrome (AIDS) is a major health problem for gay men in the United States. About three fourths of all reported cases have occurred in this population, and the number is projected to double in the next year. In Manhattan and San Francisco, AIDS is now the leading cause of premature mortality in men aged 25 to 44 years who have never married. In a sample of a cohort of gay men enrolled in a San Francisco clinic, 2.7% of the men had the syndrome and 26% had related conditions in 1984. Antibody to human T-lymphotropic virus, type III/lymphadenopathy-associated virus was found in sera from 67% of the men, including 58% of asymptomatic men. Behavioral factors associated with an increased risk of AIDS include large numbers of sexual partners, receptive anal intercourse, and "fisting." The adoption of safer lifestyles is currently the basis of attempts to control the syndrome in gay men. PMID:2996396

  10. Selenium concentration in serum of healthy Greek adults.

    Science.gov (United States)

    Van Cauwenbergh, R; Robberecht, H; Deelstra, H; Picramenos, D; Kostakopoulos, A

    1994-06-01

    Serum selenium levels of 160 healthy Greeks were determined by Zeeman-effect background-corrected atomic absorption spectrometry. Mean value for 101 men (70.7 +/- 16.2 micrograms/L) tended to be higher, but not statistically significant, compared to the mean value for 59 women (64.9 +/- 14.7 micrograms/L). When the subjects were divided into various age groups there appeared to be some increase as a function of age. Compared to the extensive literature data on serum Se levels for various countries healthy Greeks proved to be at the lower concentration range. The scarce, but conflicting literature data on serum Se values for Greeks is discussed. PMID:7881284

  11. Influence of age on smell function in healthy subjects

    Directory of Open Access Journals (Sweden)

    Savović Slobodan N.

    2002-01-01

    Full Text Available Introduction A need for research of the olfactory function exists in everyday clinical work. The aim of this study was to determine standards for perception and identification thresholds regarding olfactory substances in healthy subjects in regard to their age. Material and methods The research included 120 healthy examinees (60 women and 60 men classified according to age into three age groups (20-30, 31-40, 41-50 years of age. This examination was done using Fortunato-Niccolini's method. Results and discussion The results of this work show that olfactory function becomes significantly weaker after the age of forty. Thresholds of perception in correlation with thresholds of identification for examined olfactory substances are significantly lower in older age groups. Conclusion A gradual loss of olfactory capability with age can be explained by gradual destruction of olfactory cells and fibres of olfactory nerves during life.

  12. Gender differences in platelet aggregation in healthy individuals.

    Science.gov (United States)

    Otahbachi, Mohammad; Simoni, Jan; Simoni, Grace; Moeller, John F; Cevik, Cihan; Meyerrose, Gary E; Roongsritong, Chanwit

    2010-08-01

    This study evaluated gender variability in platelet aggregation in response to common agonists. Platelet aggregation was measured in 36 healthy men and women free of any antiplatelet medication, aged 22-36 years, of Caucasian (White not of Hispanic origin), Hispanic, and African-American not of Hispanic origin. In this ex-vivo study, we investigated platelet aggregation in response to adenosine-5'-diphosphate (ADP), epinephrine (EPI), arachidonic acid (AA) and collagen (COL), using a platelet ionized calcium aggregometer (Chrono-Log Co.). Platelet aggregation response to all tested agonists was higher in females than in males regardless of ethnicity. The most significant differences were observed with collagen (P < 0.01). Among the ethnic groups, Caucasian women were most prone to platelet aggregation. Gender is a determinant of agonist effects on platelet aggregability in healthy subjects. PMID:20039102

  13. Energy expenditure during sexual activity in young healthy couples.

    Directory of Open Access Journals (Sweden)

    Julie Frappier

    Full Text Available OBJECTIVE: To determine energy expenditure in kilocalories (kcal during sexual activity in young healthy couples in their natural environment and compare it to a session of endurance exercise. METHODS: The study population consisted of twenty one heterosexual couples (age: 22.6 ± 2.8 years old from the Montreal region. Free living energy expenditure during sexual activity and the endurance exercise was measured using the portable mini SenseWear armband. Perceived energy expenditure, perception of effort, fatigue and pleasure were also assessed after sexual activity. All participants completed a 30 min endurance exercise session on a treadmill at a moderate intensity. RESULTS: Mean energy expenditure during sexual activity was 101 kCal or 4.2 kCal/min in men and 69.1 kCal or 3.1 kCal/min in women. In addition, mean intensity was 6.0 METS in men and 5.6 METS in women, which represents a moderate intensity. Moreover, the energy expenditure and intensity during the 30 min exercise session in men was 276 kCal or 9.2 kCal/min and 8.5 METS, respectively and in women 213 kCal or 7.1 kCal/min and 8.4 METS, respectively. Interestingly, the highest range value achieved by men for absolute energy expenditure can potentially be higher than that of the mean energy expenditure of the 30 min exercise session (i.e. 306.1 vs. 276 kCal, respectively whereas this was not observed in women. Finally, perceived energy expenditure during sexual activity was similar in men (100 kCal and in women (76.2 kCal when compared to measured energy expenditure. CONCLUSION: The present study indicates that energy expenditure during sexual activity appears to be approximately 85 kCal or 3.6 kCal/min and seems to be performed at a moderate intensity (5.8 METS in young healthy men and women. These results suggest that sexual activity may potentially be considered, at times, as a significant exercise.

  14. The Body and the Beautiful: Health, Attractiveness and Body Composition in Men's and Women's Bodies.

    Science.gov (United States)

    Brierley, Mary-Ellen; Brooks, Kevin R; Mond, Jonathan; Stevenson, Richard J; Stephen, Ian D

    2016-01-01

    The dominant evolutionary theory of physical attraction posits that attractiveness reflects physiological health, and attraction is a mechanism for identifying a healthy mate. Previous studies have found that perceptions of the healthiest body mass index (weight scaled for height; BMI) for women are close to healthy BMI guidelines, while the most attractive BMI is significantly lower, possibly pointing to an influence of sociocultural factors in determining attractive BMI. However, less is known about ideal body size for men. Further, research has not addressed the role of body fat and muscle, which have distinct relationships with health and are conflated in BMI, in determining perceived health and attractiveness. Here, we hypothesised that, if attractiveness reflects physiological health, the most attractive and healthy appearing body composition should be in line with physiologically healthy body composition. Thirty female and 33 male observers were instructed to manipulate 15 female and 15 male body images in terms of their fat and muscle to optimise perceived health and, separately, attractiveness. Observers were unaware that they were manipulating the muscle and fat content of bodies. The most attractive apparent fat mass for female bodies was significantly lower than the healthiest appearing fat mass (and was lower than the physiologically healthy range), with no significant difference for muscle mass. The optimal fat and muscle mass for men's bodies was in line with the healthy range. Male observers preferred a significantly lower overall male body mass than did female observers. While the body fat and muscle associated with healthy and attractive appearance is broadly in line with physiologically healthy values, deviations from this pattern suggest that future research should examine a possible role for internalization of body ideals in influencing perceptions of attractive body composition, particularly in women. PMID:27257677

  15. The Body and the Beautiful: Health, Attractiveness and Body Composition in Men's and Women's Bodies.

    Directory of Open Access Journals (Sweden)

    Mary-Ellen Brierley

    Full Text Available The dominant evolutionary theory of physical attraction posits that attractiveness reflects physiological health, and attraction is a mechanism for identifying a healthy mate. Previous studies have found that perceptions of the healthiest body mass index (weight scaled for height; BMI for women are close to healthy BMI guidelines, while the most attractive BMI is significantly lower, possibly pointing to an influence of sociocultural factors in determining attractive BMI. However, less is known about ideal body size for men. Further, research has not addressed the role of body fat and muscle, which have distinct relationships with health and are conflated in BMI, in determining perceived health and attractiveness. Here, we hypothesised that, if attractiveness reflects physiological health, the most attractive and healthy appearing body composition should be in line with physiologically healthy body composition. Thirty female and 33 male observers were instructed to manipulate 15 female and 15 male body images in terms of their fat and muscle to optimise perceived health and, separately, attractiveness. Observers were unaware that they were manipulating the muscle and fat content of bodies. The most attractive apparent fat mass for female bodies was significantly lower than the healthiest appearing fat mass (and was lower than the physiologically healthy range, with no significant difference for muscle mass. The optimal fat and muscle mass for men's bodies was in line with the healthy range. Male observers preferred a significantly lower overall male body mass than did female observers. While the body fat and muscle associated with healthy and attractive appearance is broadly in line with physiologically healthy values, deviations from this pattern suggest that future research should examine a possible role for internalization of body ideals in influencing perceptions of attractive body composition, particularly in women.

  16. Impulsivity, gender, and the platelet serotonin transporter in healthy subjects

    Directory of Open Access Journals (Sweden)

    Donatella Marazziti

    2009-12-01

    Full Text Available Donatella Marazziti, Stefano Baroni, Irene Masala, Francesca Golia, Giorgio Consoli, Gabriele Massimetti, Michela Picchetti, Mario Catena Dell’Osso, Gino Giannaccini, Laura Betti, Antonio Lucacchini, Antonio CiapparelliDipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, ItalyAbstract: The present study explored the possible relationships between impulsivity, gender, and a peripheral serotonergic marker, the platelet serotonin (5-HT transporter (SERT, in a group of 32 healthy subjects. The impulsivity was measured by means of the Barratt Impulsivity Scale, version 11 (BIS-11, a widely used self-report questionnaire, and the platelet SERT was evaluated by means of the specific binding of 3H-paroxetine (3H-Par to platelet membranes, according to standardized protocols. The results showed that women had a higher BIS-11 total score than men, and also higher scores of two factors of the same scale: the motor impulsivity and the cognitive complexity. The analysis of the correlations revealed that the density of the SERT proteins, as measured by the maximum binding capacity (Bmax of 3H-Par, was significantly and positively related to the cognitive complexity factor, but only in men. Men showed also a significant and negative correlation with the dissociation constant, Kd, of (3H-Par binding, and the motor impulsivity factor. These findings suggest that women are generally more impulsive than men, but that the 5-HT system is more involved in the impulsivity of men than in that of women.Keywords: impulsivity, gender, serotonin transporter, Barratt Impulsivity Scale, platelets, 3H-paroxetine

  17. Healthy Children, Healthy Minds: Creating a Brighter Future

    Directory of Open Access Journals (Sweden)

    Marcel Lebrun

    2015-09-01

    Full Text Available Children struggle with life today. Being children in the 21st century is both taxing and exciting and yet trying to cope with all of the technology and media that surrounds them. How do we as adults provide good models? Mindfulness, exercise, focus and attention, healthy living strategies need to play a role in shaping healthy children. Educators need to become well versed in strategies that both teach short and long term behaviors that will sustain healthy living and healthy minds. Children are the future and what kind of adult do we want running our countries and the world. The article provides many strategies for educators and parents to guide children in making choices that are both empowering and allow them the flexibility to be children.

  18. Healthy meals on the menu

    DEFF Research Database (Denmark)

    Thunström, Linda; Nordström, Leif Jonas; Shogren, Jason

    2016-01-01

    Menu labelling of meals prepared away from home is a policy designed to help consumers make healthier food choices. In this paper we use a field experiment in Sweden to examine if a restaurant benefits from introducing a meal labelled as healthy on its menu by experiencing an overall increase in...... sales. We cannot reject the hypothesis that sales are the same before and after the introduction of a meal labelled as healthy on the menu, i.e. our data does not support the idea that restaurants increase their sales from supplying a meal labelled as healthy....

  19. Un menú diferente

    OpenAIRE

    Gil Molina, Pilar

    2011-01-01

    Duración (en horas): De 11 a 20 horas. Nivel educativo: Grado n menú diferente para un alumno diferente es el detonante de un conflicto cognitivo en un grupo de escolares de la etapa de Educación Infantil. El caso describe una situación diferente y compleja (menores inmigrantes no acompañados, cultura musulmana, alimentación halal, etc.) a la que el pensamiento infantil ha de acomodarse y en la que la intervención de una educadora no parece ser de ayuda. Esta diseñado para aplicar ...

  20. The Dutch Healthy Diet index (DHD-index): an instrument to measure adherence to the Dutch Guidelines for a Healthy Diet

    OpenAIRE

    van Lee Linde; Geelen Anouk; van Huysduynen EvelineJCHooft; de Vries Jeanne H M; van’t Veer Pieter; Feskens Edith J M

    2012-01-01

    Abstract Background The objective was to develop an index based on the Dutch Guidelines for a healthy Diet of 2006 that reflects dietary quality and to apply it to the Dutch National Food Consumption Survey (DNFCS) to examine the associations with micronutrient intakes. Methods A total of 749 men and women, aged 19–30 years, contributed two 24-hour recalls and additional questionnaires in the DNFCS of 2003. The Dutch Healthy Diet index (DHD-index) includes ten components representing the ten ...

  1. Men's Sheds: enabling environments for Australian men living with and without long-term disabilities.

    Science.gov (United States)

    Hansji, Neeraj L; Wilson, Nathan J; Cordier, Reinie

    2015-05-01

    The health of Australian men has recently received greater attention. Men's Sheds are named in national policy as an exemplar community-based organisation for the betterment of men's psychosocial health; yet, the evidence base to support this is limited. This study investigates the comparative experience of men with long-term disabilities and men without long-term disabilities who go to a Men's Shed and to what extent this provides these men with an enabling, as opposed to disabling, environment. Data were collected from 12 individual interviews with men with long-term disabilities (5) and men without long-term disabilities (6), including 1 interview with the male Men's Shed Coordinator (MSC); participant observation within the shed; and a document received from the female MSC regarding the funding the Shed receives. Interviews explored the men's experiences at the Shed and their sense of belonging and social inclusion. Participants had any type of long-term disability and had been attending the shed for a minimum of 1 month. Data were collected between May and September 2013 and were analysed using the constant comparative method of grounded theory. The core theme that emerged was an enabling community space. The four sub-themes were: a community and social hub; an equalising space; a safe and supportive male environment; and meaningful male activities. The current literature exemplifies Men's Sheds to be important community-based organisations beneficial to men's health and well-being. For men living with long-term disabilities, this study illuminates that Men's Sheds offer an environment of equality, facilitating a collegial and egalitarian culture. Men can partake in enabling activities and enjoy the company of other men enhancing their sense of belonging and social inclusion as well as interact with other community groups that occupy the same space as the Men's Shed. PMID:25428844

  2. Men with Low Vitamin A Stores Respond Adequately to Primary Yellow Fever and Secondary Tetanus Toxoid Vaccination

    Science.gov (United States)

    Current recommendations for vitamin A intake and liver stores (20 mg/g) are based on maintaining normal vision. Higher levels may be required for maintaining normal immune function. To test this hypothesis, we conducted an 8 wk residential study among 36 healthy Bangladeshi men with low serum retino...

  3. Coincidence of deficient delayed hypersensitivity and intestinal protozoa in homosexual men.

    Science.gov (United States)

    Jokipii, L; Sargeaunt, P G; Jokipii, A M

    1989-01-01

    Stool samples of 134 subjectively and apparently healthy male homosexual volunteers were studied, and in 86 men (64.2%) 190 parasite infestations, up to 6 per host, were identified. The most frequent species were Endolimax nana (40), Entamoeba coli (38), Entamoeba histolytica (34), Entamoeba hartmanni (32), and Iodamoeba bütschlii (22); Cryptosporidium was not found. All 11 isolates of Entamoeba histolytica analysed belonged to a noninvasive zymodeme: 10 were of zymodeme I and I of zymodeme III. In 172 healthy control adults 6 parasite infestations were found. In the homosexual men, a negative tuberculin test was more frequent in the presence than in the absence of parasites. Entamoeba histolytica (p = 0.005) Entamoeba coli (p = 0.013) and Iodamoeba bütschlii (p = 0.004) were associated with the anergy. PMID:2555912

  4. Progesterone and Cerebral Function during Emotion Processing in Men and Women with Schizophrenia

    Directory of Open Access Journals (Sweden)

    Julie Champagne

    2012-01-01

    Full Text Available Schizophrenia has been associated with disturbed levels of sex-steroid hormones, including estrogen and testosterone. In the present study we have examined the implication of a less studied hormone progesterone. Forty-three patients with schizophrenia (21 women and 43 control participants (21 women underwent functional MRI while viewing emotionally positive, negative, and neutral images. Blood samples were taken prior to the scanning session to evaluate progesterone levels. Simple regression analyses between levels of progesterone and brain activations associated with emotion processing were performed using SPM5. A positive correlation was found between progesterone levels and brain activations during processing of emotionally charged images in both healthy and schizophrenia men, but no significant relationship was revealed in women. These preliminary results indicate that progesterone is significantly associated with brain activations during processing of positive and negative affect in healthy and schizophrenia men, but not in women. Further investigation is warranted.

  5. Enhanced satellite cell proliferation with resistance training in elderly men and women

    DEFF Research Database (Denmark)

    Mackey, Abigail; Esmarck, B; Kadi, F;

    2007-01-01

    In addition to the well-documented loss of muscle mass and strength associated with aging, there is evidence for the attenuating effects of aging on the number of satellite cells in human skeletal muscle. The aim of this study was to investigate the response of satellite cells in elderly men and...... women to 12 weeks of resistance training. Biopsies were collected from the m. vastus lateralis of 13 healthy elderly men and 16 healthy elderly women (mean age 76+/-SD 3 years) before and after the training period. Satellite cells were visualized by immunohistochemical staining of muscle cross......-sections with a monoclonal antibody against neural cell adhesion molecule (NCAM) and counterstaining with Mayer's hematoxylin. Compared with the pre-training values, there was a significant increase (P<0.05) in the number of NCAM-positively stained cells per fiber post-training in males (from 0.11+/-0.03 to 0...

  6. The experiments on healthy animals

    International Nuclear Information System (INIS)

    In this chapter author made conclusion that leading the mumio preparation to healthy rats promote the rising of leucocytes quantity in peripheral blood, nucleus containing cells of marrow and spleen in comparison with initials

  7. The experiments on healthy animals

    International Nuclear Information System (INIS)

    In this chapter author describes the experiments on leukotitin influence on hematosis which was held on :1. healthy animals received the preparation; 2. irradiated animals received the preparation; 3. irradiated animals didn't receive the preparation

  8. Nutrition for healthy term infants

    OpenAIRE

    1998-01-01

    Nutrition for Healthy Term Infants is the new national statement on nutrition for infants from birth to 24 months, developed collaboratively by the Canadian Paediatric Society, Dietitians of Canada and Health Canada.

  9. MedlinePlus: Healthy Aging

    Science.gov (United States)

    ... Health screening - women - over 65 Related Health Topics Exercise for Seniors Nutrition for Seniors Seniors' Health National Institutes of Health The primary NIH organization for research on Healthy Aging is the National Institute on Aging Languages ...

  10. Molecular breeding of healthy vegetables

    OpenAIRE

    Irwin L Goldman

    2011-01-01

    Breeders and plant scientists are increasing their efforts to raise the health benefits of fruits and vegetables. Yet, the positive impact of this on public health, it is not a substitute for a healthy diet.

  11. Staying Healthy on a Cruise

    Science.gov (United States)

    ... on healthy travel, visit the Travelers' Health website . Travel Health Insurance and Evacuation Insurance You should check with ... board the ship. If not, you can purchase travel health insurance to cover you during your trip. Also, ...

  12. Healthy Heart Handbook for Women

    Science.gov (United States)

    ... Should I see a registered dietitian or qualified nutritionist to learn more about healthy eating? 10. How ... pounds a week. See your doctor or a nutritionist if you need help. Source: “Clinical Guidelines on ...

  13. Factors affecting leukocyte count in healthy adults.

    Science.gov (United States)

    Carel, R S; Eviatar, J

    1985-09-01

    The relationships between white blood cell (WBC) count, smoking, and other health variables were determined among 35,000 apparently healthy men and women. The effect of smoking on the WBC count was greater than that of all other variables. The leukocyte level and the variance in WBC count values increased with increased smoking intensity. The relationship between smoking intensity and leukocyte level is expressed quantitatively by the following regression equation: WBC (10(3)/mm3) = 7.1 + 0.05(SM), where SM has seven values according to the smoking level. Multiple regression analysis with additional variables other than smoking did not much improve the predictive value of the equation. The effect of smoking on WBC count could be only partially explained by an inflammatory process, e.g., chronic bronchitis. Relationships of statistical significance (but mostly with r values of less than 0.10) were found between WBC count and the following variables: hemoglobin, heart rate, weight (or Quetelet index), cholesterol, uric acid, creatinine, sex, ethnic origin, systolic blood pressure, height, blood sugar, and diastolic blood pressure. The normal WBC count range for smokers differs from that of nonsmokers and is shifted to the right according to the smoking level. This may have both a diagnostic and prognostic significance in different clinical settings. PMID:4070192

  14. Suicides in men with IDDM

    DEFF Research Database (Denmark)

    Kyvik, K O; Stenager, E N; Green, A;

    1994-01-01

    OBJECTIVE: To investigate the occurrence of suicide in men with insulin-dependent diabetes mellitus (IDDM). RESEARCH DESIGN AND METHODS: A cohort of all Danish men born between 1949 and 1964 (including 1964) who were diagnosed with IDDM before age 20 (n = 1,682) was ascertained earlier. Follow...... ratios (SMRs), adjusted for age and calendar time, were calculated. RESULTS: Among the 168 deaths recorded during follow-up, 15 took place in connection with the onset of IDDM and have been excluded. Of the remaining 153 deaths, 12 were officially classified as suicides (SMR 12/7.48 = 1.6, 0.05 < P < 0.......1); as for the age-group of 20-24 years, SMR was 2.98, P < 0.05. Furthermore, all deaths officially classified as attributable to unknown causes (n = 28) and accidents (n = 22) were reviewed with respect to unrecognized suicides; as for deaths of unknown causes, three could be reclassified as probable...

  15. Men, women, gender and cancer.

    Science.gov (United States)

    Moynihan, C

    2002-09-01

    This paper argues for a gender relational approach in the context of cancer care bearing in mind that conceptual problems are intertwined with methodological approaches. Hitherto, research in the field of psycho-oncology has used a positivist methodology that separates sex from 'gender'. Men's and women's biological difference dictates their sexual destiny. Moreover, adjustment to cancer is conceptualized as lying within the patient, usually women. A contextual framework of a person's experience is negated. A 'gender relational' approach to cancer care underpins the ways in which people enter into a set of socially constructed relationships produced and reproduced through actions with each other and in institutions but never in a vacuum. It is suggested that, by using differing methodologies, such an approach will illuminate the similarities and differences within and between men and women with cancer. It may also help to demystify the conceptual stance that often pathologizes and medicalizes people, especially women, as has been the case in mainstream research. This will pave the way for a clearer understanding of how patients experience cancer in terms of gender and how medical institutions may be contributing to that experience as they too, gender their practice. PMID:12296832

  16. Adherence to the WHO’s Healthy Diet Indicator and Overall Cancer Risk in the EPIC-NL Cohort

    OpenAIRE

    Berentzen, Nina E.; Beulens, Joline W.; Marieke P Hoevenaar-Blom; Ellen Kampman; Bas Bueno-de-Mesquita, H.; Dora Romaguera-Bosch; Peeters, Petra H.M.; May, Anne M.

    2013-01-01

    BACKGROUND: A healthy dietary pattern defined by international recommendations of the World Health Organisation (WHO) has been shown to reduce overall mortality risk. It is unknown whether this healthy dietary pattern is associated with overall cancer incidence. DESIGN: In total 35,355 men and women within the Dutch European Prospective Investigation into Cancer and Nutrition-cohort were followed for cancer occurrence. Diet was assessed through a validated food-frequency questionnaire. We com...

  17. Implication of Sarcopenia and Sarcopenic Obesity on Lung Function in Healthy Elderly: Using Korean National Health and Nutrition Examination Survey

    OpenAIRE

    Moon, Ji Hyun; Kong, Mi Hee; Kim, Hyeon Ju

    2015-01-01

    Previous studies have demonstrated a positive association between obesity and decreased lung function. However, the effect of muscle and fat has not been fully assessed, especially in a healthy elderly population. In this study, we evaluated the impact of low muscle mass (LMM) and LMM with obesity on pulmonary impairment in healthy elderly subjects. Our study used data from the Korea National Health and Nutrition Examination Survey from 2008 to 2011. Men and women aged 65 yr or older were inc...

  18. Gender- and Age-Specific REE and REE/FFM Distributions in Healthy Chinese Adults.

    Science.gov (United States)

    Cheng, Yu; Yang, Xue; Na, Li-Xin; Li, Ying; Sun, Chang-Hao

    2016-01-01

    Basic data on the resting energy expenditure (REE) of healthy populations are currently rare, especially for developing countries. The aims of the present study were to describe gender- and age-specific REE distributions and to evaluate the relationships among glycolipid metabolism, eating behaviors, and REE in healthy Chinese adults. This cross-sectional survey included 540 subjects (343 women and 197 men, 20-79 years old). REE was measured by indirect calorimetry and expressed as kcal/day/kg total body weight. The data were presented as the means and percentiles for REE and the REE to fat-free mass (FFM) ratio; differences were described by gender and age. Partial correlation analysis was used to analyze the correlations between REE, tertiles of REE/FFM, and glycolipid metabolism and eating behaviors. In this study, we confirmed a decline in REE with age in women (p = 0.000) and men (p = 0.000), and we found that men have a higher REE (p = 0.000) and lower REE/FFM (p = 0.021) than women. Furthermore, we observed no associations among glycolipid metabolism, eating behaviors, and REE in healthy Chinese adults. In conclusion, the results presented here may be useful to clinicians and nutritionists for comparing healthy and ill subjects and identifying changes in REE that are related to aging, malnutrition, and chronic diseases. PMID:27598192

  19. Proinsulin and insulin responses to a mixed meal in hypertriglyceridaemic men.

    OpenAIRE

    Gama, R.; Norris, F; S. Hampton; Morgan, L; Wright, J.; Marks, V.

    1999-01-01

    AIM: To investigate the contribution of proinsulin to the "hyperinsulinaemia" of hypertriglyceridaemia. METHODS: Plasma glucose, triglyceride, immunoreactive insulin, and intact proinsulin concentrations were measured before and after a mixed meal in 11 hypertriglyceridaemic men and six healthy normotriglyceridaemic male controls. RESULTS: Hypertriglyceridaemic subjects had greater fasting (101 v 50 pmol/l) and integrated (139 v 81 x 0(-3) pmol/l/h) insulin concentrations than controls. Fasti...

  20. A High Legume Low Glycemic Index Diet Improves Serum Lipid Profiles in Men

    OpenAIRE

    Zhang, Zhiying; Lanza, Elaine; Kris-Etherton, Penny M.; Colburn, Nancy H.; Bagshaw, Deborah; Rovine, Michael J.; Ulbrecht, Jan S.; Bobe, Gerd; Chapkin, Robert S.; Hartman, Terryl J.

    2010-01-01

    Clinical studies have shown that fiber consumption facilitates weight loss and improves lipid profiles; however, the beneficial effects of high fermentable fiber low glycemic index (GI) diets under conditions of weight maintenance are unclear. In the Legume Inflammation Feeding Experiment, a randomized controlled cross-over feeding study, 64 middle-aged men who had undergone colonoscopies within the previous 2 years received both a healthy American (HA) diet (no legume consumption, fiber cons...