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Sample records for atlas experimental cavern

  1. Constructing the ATLAS experimental cavern

    CERN Multimedia

    Laurent Guiraud

    2001-01-01

    The huge cavern that will house the ATLAS experiment on the LHC at CERN is seen in these images during construction. The site, located 100 m underground near the France-Swiss border, has one of the longest underground spans ever built at 35 m. The 1380 square metre cavern that will hold the 46X25X25 cubic metre detector (the largest of its type in the world) requires its ceiling to be held by ground anchors installed from galleries excavated laterally from the access shafts.

  2. ATLAS Cavern baseplate

    CERN Multimedia

    It-UDS-Audiovisual Services

    2002-01-01

    This video shows the incredible amounth of iron used for ATLAS cavern. Please look at the related links and also videos that are concerning the civil engineering where you can see even more detailed cavern excavation work.

  3. The huge ATLAS cavern now fully excavated

    CERN Multimedia

    2002-01-01

    Excavation of the ATLAS cavern is now complete! At the end of two years' work involving a tremendous technical challenge, the civil engineering contractors have succeeded in digging out one of the biggest experimental caverns in the world. Bravo!

  4. Surveying the ATLAS cavern

    CERN Multimedia

    Laurent Guiraud

    2000-01-01

    The cathedral-like cavern into which the ATLAS experiment will be lowered and installed forms a vital part of the engineering work at CERN in preparation for the new LHC accelerator. This cavern, being measured by surveyors in these images, will have one of the largest spans of any man-made underground structure. The massive 46X25X25 cubic metre detector will be the largest of its type in the world when it is completed for the LHC start-up in 2008.

  5. 29 May 2013 - Rector Politecnico di Torino M. Gilli in the ATLAS experimental cavern with L. Pontecorvo (ATLAS Collaboration) and in the LHC tunnel at Point 1 with Engineering Department Head R. Saban.

    CERN Multimedia

    VMO

    2013-01-01

    29 May 2013 - Rector Politecnico di Torino M. Gilli in the ATLAS experimental cavern with L. Pontecorvo (ATLAS Collaboration) and in the LHC tunnel at Point 1 with Engineering Department Head R. Saban.

  6. 09 September 2013 - Japanese Members of Internal Affairs and Communications Committee House of Representatives visiting the ATLAS experimental cavern with ATLAS Spokesperson D. Charlton. T. Kondo and K. Yoshida present.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    09 September 2013 - Japanese Members of Internal Affairs and Communications Committee House of Representatives visiting the ATLAS experimental cavern with ATLAS Spokesperson D. Charlton. T. Kondo and K. Yoshida present.

  7. The ATLAS cavern in the spotlight

    CERN Multimedia

    On Wednesday, 4th June, the President of the Swiss Confederation, Pascal Couchepin, inaugurated the world's largest experimental cavern, which is to house the ATLAS detector in 2007, and announced Switzerland's gift to CERN of the "Palais de l'Equilibre".

  8. The CMS experimental cavern

    CERN Multimedia

    Maximilien Brice

    2005-01-01

    These images taken in early September 2005 show the cathedral-like cavern into which the CMS experiment will be installed. The 26X26X60 cubic metre hall is the largest underground cavern at CERN, located under the town of Cessy in France. Weighing 12 500 tonnes, the huge CMS detector will be assembled in a specially constructed hall above ground before being lowered into the experimental hall ready for the LHC start-up in 2008.

  9. 27 Febuary 2012 - US DoE Associate Director of Science for High Energy Physics J. Siegrist visiting the LHC superconducting magnet test hall with adviser J.-P. Koutchouk and engineer M. Bajko; in CMS experimental cavern with Spokesperson J. Incadela;in ATLAS experimental cavern with Deputy Spokesperson A. Lankford; in ALICE experimental cavern with Spokesperson P. Giubellino; signing the guest book with Director for Accelerators and Technology S. Myers.

    CERN Multimedia

    Laurent Egli

    2012-01-01

    27 Febuary 2012 - US DoE Associate Director of Science for High Energy Physics J. Siegrist visiting the LHC superconducting magnet test hall with adviser J.-P. Koutchouk and engineer M. Bajko; in CMS experimental cavern with Spokesperson J. Incadela;in ATLAS experimental cavern with Deputy Spokesperson A. Lankford; in ALICE experimental cavern with Spokesperson P. Giubellino; signing the guest book with Director for Accelerators and Technology S. Myers.

  10. ATLAS Cavern - Sainte-Barbe evening

    CERN Document Server

    2002-01-01

    The December at cavern of ATLAS was full of surprises, while during the iron mounting and concrete work the cavern got its new purpose for being the restaurant under little while -Live music and happy people.

  11. 12 April 2013 - The British Royal Academy of Engineering visiting the LHC superconducting magnet test hall with R. Veness and the ATLAS experimental cavern with Collaboration Spokesperson D. Charlton.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    12 April 2013 - The British Royal Academy of Engineering visiting the LHC superconducting magnet test hall with R. Veness and the ATLAS experimental cavern with Collaboration Spokesperson D. Charlton.

  12. Civil engineering in the ATLAS cavern

    CERN Multimedia

    Laurent Guiraud

    2000-01-01

    Work continues in the cathedral-like cavern that will soon contain ATLAS, the largest particle detector of its type in the world. For such a huge detector, an equally giant cavern must be excavated 100 m underground. The roof must be held without any normal rests at the base; instead it will be supported by huge anchors embedded in concrete that will stop the roof from caving in, located in galleries above the cavern.

  13. 16 December 2013 - Hooke Professor of Experimental Physics and Pro Vice Chancellor University of Oxford Prof. I. Walmsley visiting the ATLAS cavern with ATLAS Collaboration Deputy Spokesperson T. Wengler, Physics Department, ATLAS Collaboration P. Wells and Chair, CMS Collaboration Board, Oxford University and Purdue University I. Shipsey

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    16 December 2013 - Hooke Professor of Experimental Physics and Pro Vice Chancellor University of Oxford Prof. I. Walmsley visiting the ATLAS cavern with ATLAS Collaboration Deputy Spokesperson T. Wengler, Physics Department, ATLAS Collaboration P. Wells and Chair, CMS Collaboration Board, Oxford University and Purdue University I. Shipsey

  14. 30 August 2013 - Senior Vice Minister for Foreign Affairs in Japan M. Matsuyama signing the guest book with CERN Director-General; visit the ATLAS experimental cavern with ATLAS Spokesperson D. Charlton and visiting the LHC tunnel at Point 1 with former ATLAS Japan national contact physicist T. Kondo. R. Voss and K. Yoshida present throughout.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    30 August 2013 - Senior Vice Minister for Foreign Affairs in Japan M. Matsuyama signing the guest book with CERN Director-General; visit the ATLAS experimental cavern with ATLAS Spokesperson D. Charlton and visiting the LHC tunnel at Point 1 with former ATLAS Japan national contact physicist T. Kondo. R. Voss and K. Yoshida present throughout.

  15. Civil Engineering in the ATLAS cavern

    CERN Multimedia

    Laurent Guiraud

    2000-01-01

    Ghostly figures can be seen wandering the cavern that will eventually house the ATLAS experiment, part of the LHC at CERN. Quite fitting since the detector will hunt the illusive 'ghostly' particles, such as the Higgs boson and dark matter. These engineers are excavating the huge cavern that has to be anchored from above as the detector will fill so much space that there is no room for support pillars.

  16. Special people visit the ATLAS cavern

    CERN Multimedia

    Muriel

    ATLAS has been host to many important visitors lately. Here are a selected few: Professor Stephen Hawking visits the ATLAS cavern On Tuesday 26 September 2006 the ATLAS Collaboration was honoured by a very special visit to the detector in the underground cavern. We were pleased to guide Professor Stephen Hawking, the famous cosmologist holding the post of Lucasian Professor of Mathematics at Cambridge University (position held by Isaac Newton in the 17th century), on a tour of the ATLAS pit and the LHC tunnel. The visit was accompanied by a few colleagues from the CERN Theory group, and was only possible thanks to the professional assistance of Olga Beltramello and Bernard Lebegue, who had also taken care of all the necessary preparatory work in the cavern. Professor Hawking was very keen to check for himself the status of the detector installation, and he admired, in particular, the spectacular TGC big wheel on side C. (left) Stephen Hawking in the ATLAS cavern side-C (right) and in the LHC tunnel...

  17. Installation of the Liquid Argon Calorimater Barrel in the ATLAS Experimental Cavern

    CERN Multimedia

    Vandoni, G.

    On the 27th of October, the Liquid Argon Barrel cryostat was transported from Building 180 to point 1. The next day, the Barrel was lowered into the cavern, and was placed on jacks close to its final position inside the completed lower half of the Tile calorimeter. After a day of precise adjustment, it was resting within a few millimetres of its nominal final position, waiting for the upper half of the Tile calorimeter to be installed. Tight requests had been issued by the Liquid Argon collaboration for the whole transport. It was foreseen that the cryostat should not see any acceleration larger than 0.15g along its axis, 0.08g transversally and 0.3g in the vertical direction. In addition, no acceleration higher than 0.03g (or even 0.003g for permanent oscillation) would be allowed at 20Hz, to avoid the risk of damaging the absorbers at this spontaneous vibration frequency. The difficulty would arise when coping these demands with the tortuous route, its slopes and curbs, vibration transmission from the engi...

  18. Digging the CMS experimental cavern

    CERN Multimedia

    Laurent Guiraud

    2001-01-01

    The huge CMS experimental cavern is located 100 m underground and has two access shafts through which the experiment's components will be lowered. Initially assembled on the surface, each part of the 12 500 tonne machine must be lowered individually with very little clearance.

  19. 8 October 2013 - Rolex Director- General G. Marini in the ATLAS Control Room with CERN Director-General R. Heuer and ATLAS Collaboration Senior Physicist C. Rembser; visiting the ATLAS experimental cavern at LHC Point 1. Were also present from the Directorate: S. Lettow, Director for Administration and General Infrastructure; from the ATLAS Collaboration: Technische Universitaet Dortmund (DE) J. Jentzsch and SLAC National Accelerator Laboratory (US) G. Piacquadio.

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    8 October 2013 - Rolex Director- General G. Marini in the ATLAS Control Room with CERN Director-General R. Heuer and ATLAS Collaboration Senior Physicist C. Rembser; visiting the ATLAS experimental cavern at LHC Point 1. Were also present from the Directorate: S. Lettow, Director for Administration and General Infrastructure; from the ATLAS Collaboration: Technische Universitaet Dortmund (DE) J. Jentzsch and SLAC National Accelerator Laboratory (US) G. Piacquadio.

  20. 19 July 2013 - Chairman of the Policy Committee, European Cancer Organisation, President, European Association for Cancer Research E. Celis visiting the ATLAS experimental cavern with ATLAS Collaboration Deputy Spokesperson, B. Heinemann and signing the Guest Book with Director for Accelerators and Technology S. Myers. Life Sciences Adviser M. Dosanjh present.

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    19 July 2013 - Chairman of the Policy Committee, European Cancer Organisation, President, European Association for Cancer Research E. Celis visiting the ATLAS experimental cavern with ATLAS Collaboration Deputy Spokesperson, B. Heinemann and signing the Guest Book with Director for Accelerators and Technology S. Myers. Life Sciences Adviser M. Dosanjh present.

  1. 9 April 2013 - Minister for Universities and Science United Kingdom of Great Britain and Northern Ireland D. Willetts in the ATLAS experimental cavern with ATLAS Collaboration Spokesperson D. Charlton and in the LHC tunnel at Point 1 with Beams Department Head P. Collier. Director for Accelerators and Technology S. Myers, Editor at the Communication Group K. Kahle and Beams Department Engineer R. Veness present.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    9 April 2013 - Minister for Universities and Science United Kingdom of Great Britain and Northern Ireland D. Willetts in the ATLAS experimental cavern with ATLAS Collaboration Spokesperson D. Charlton and in the LHC tunnel at Point 1 with Beams Department Head P. Collier. Director for Accelerators and Technology S. Myers, Editor at the Communication Group K. Kahle and Beams Department Engineer R. Veness present.

  2. 23 July - Italian Director-General for Prevention G. Ruocco and Director-General for European and International Relations Ministry of Health D. Roderigo visiting the ATLAS experimental cavern with ATLAS Deputy Spokesperson B. Heinemann. Life Sciences Section M. Cirilli and Life Sciences Adviser M. Dosanjh present.

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    23 July - Italian Director-General for Prevention G. Ruocco and Director-General for European and International Relations Ministry of Health D. Roderigo visiting the ATLAS experimental cavern with ATLAS Deputy Spokesperson B. Heinemann. Life Sciences Section M. Cirilli and Life Sciences Adviser M. Dosanjh present.

  3. 1 October 2013 - British Minister of State for Trade and Investment Lord Green of Hurstpierpoint signing the guest book with Head of Internationals Relations R. Voss; visiting the LHC tunnel at Point 1 and the ATLAS experimental cavern with ATLAS Collaboration Members K. Behr and J. Catmore.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    1 October 2013 - British Minister of State for Trade and Investment Lord Green of Hurstpierpoint signing the guest book with Head of Internationals Relations R. Voss; visiting the LHC tunnel at Point 1 and the ATLAS experimental cavern with ATLAS Collaboration Members K. Behr and J. Catmore.

  4. 13 September 2013 - Chairman of the Board of Directors of the von Karman Institute Kingdom of Belgium J.-P. Contzen visiting the ATLAS experimental cavern with ATLAS Former Spokesperson P. Jenni; visiting the LHC tunnel at Point 1 with Technology Department N. Delruelle and signing the guest book with Technology Department Head F. Bordry. International Relations Adviser T. Kurtyka present.

    CERN Multimedia

    Laurent Egli (visit)

    2013-01-01

    13 September 2013 - Chairman of the Board of Directors of the von Karman Institute Kingdom of Belgium J.-P. Contzen visiting the ATLAS experimental cavern with ATLAS Former Spokesperson P. Jenni; visiting the LHC tunnel at Point 1 with Technology Department N. Delruelle and signing the guest book with Technology Department Head F. Bordry. International Relations Adviser T. Kurtyka present.

  5. 17 April 2013 - UK Queen Mary University London Principal S. Gaskell in the ATLAS control room at LHC Point 1, LHC tunnel and ATLAS experimental cavern with Collaboration Spokesperson D. Charlton and signing the guest book with CERN Director for Accelerators and Technology S. Myers.

    CERN Multimedia

    Maximilien Brice

    2013-01-01

    17 April 2013 - UK Queen Mary University London Principal S. Gaskell in the ATLAS control room at LHC Point 1, LHC tunnel and ATLAS experimental cavern with Collaboration Spokesperson D. Charlton and signing the guest book with CERN Director for Accelerators and Technology S. Myers.

  6. ATLAS - End-Cap calorimeter lowered in to the cavern

    CERN Multimedia

    2006-01-01

    The End-cap calorimeter was lowered into the ATLAS cavern at POINT1. This calorimeter will measure the energy of particles close to the beam axis when protons collide. Cooling is important for maximum detector efficiency.

  7. 2 April 2014 - H. E. Mr Joachim Gauck, President of the Federal Republic of Germany in the ATLAS experimental cavern with Director-General R. Heuer.

    CERN Multimedia

    Brice, Maximilien

    2014-01-01

    in the ATLAS cavern: Minister of State at the Federal Foreign Office M. Böhmer (green jacket) and Mrs daniela Schadt (First Lady). 201404-069_39.jpg: State Secretary, Federal Ministry of Education and Research G. Schütte, Minister of State at the Federal Foreign Office M. Böhmer, President Gauck, CERN DG, State Secretary, Chief of the Federal President´s Office D. Gill and Ambassador of the Federal Republic of Germany to the Swiss Confederation O. Lampe.

  8. 3 May 2014 - His Excellency Dr Karolos Papoulias President of the Hellenic Republic in the LHC tunnel at Point 1 and in ATLAS experimental cavern with Director-General R. Heuer.

    CERN Multimedia

    Brice, Maximilien

    2014-01-01

    In the LHC tunnel at Point 1: Beams Department, Controls Group Leader E. Hatziangeli and Technology Department, Cryogenics Group Deputy Leader D. Delikaris. In the ATLAS cavern: ATLAS Deputy Spokesperson B. Heinemann and ATLAS Collaboration National contact person and CAST Collaboration National Technical University of Athens Team Leader E. Gazis.

  9. 6 November 2013 - Permanent Representative of Chile to the United Nations Office and Other international organizations in Geneva Ambassador J. Balmaceda Serigos signing the guest book with Adviser for Latin America J. Salicio Diez; visiting the ATLAS experimental cavern with Spokesperson D. Charlton (Spouse, Son and First Secretary present).

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    6 November 2013 - Permanent Representative of Chile to the United Nations Office and Other international organizations in Geneva Ambassador J. Balmaceda Serigos signing the guest book with Adviser for Latin America J. Salicio Diez; visiting the ATLAS experimental cavern with Spokesperson D. Charlton (Spouse, Son and First Secretary present).

  10. 3 February 2011 - British Members of the Science and Technology Committee (Commons)led by A. Miller MP signing the guest book with CERN Director for Accelerators and Technology S. Myers; in the ATLAS experimental cavern at LHC Point 1 with Spokesperson F. Gianotti and Deputy D. Charlton.

    CERN Document Server

    Maximilien Brice

    2011-01-01

    3 February 2011 - British Members of the Science and Technology Committee (Commons)led by A. Miller MP signing the guest book with CERN Director for Accelerators and Technology S. Myers; in the ATLAS experimental cavern at LHC Point 1 with Spokesperson F. Gianotti and Deputy D. Charlton.

  11. 28 March 2014 - Italian Minister of Education, University and Research S. Giannini welcomed by CERN Director-General R. Heuer and Director for Research and Scientific Computing S. Bertolucci in the ATLAS experimental cavern with Former Collaboration Spokesperson F. Gianotti. Signature of the guest book with Belgian State Secretary for the Scientific Policy P. Courard.

    CERN Multimedia

    Gadmer, Jean-Claude

    2014-01-01

    28 March 2014 - Italian Minister of Education, University and Research S. Giannini welcomed by CERN Director-General R. Heuer and Director for Research and Scientific Computing S. Bertolucci in the ATLAS experimental cavern with Former Collaboration Spokesperson F. Gianotti. Signature of the guest book with Belgian State Secretary for the Scientific Policy P. Courard.

  12. 21 January 2008 - Vice-President of the Human Rights Commission Z. Muhsin Al Hussein, Ambassador to United Nations A. Attar and their delegation from Saudi Arabia, visiting the ATLAS experimental cavern with Collaboration Spokesperson P. Jenni and Technical Coordinator M. Nessi.

    CERN Multimedia

    Claudia Marcelloni

    2008-01-01

    21 January 2008 - Vice-President of the Human Rights Commission Z. Muhsin Al Hussein, Ambassador to United Nations A. Attar and their delegation from Saudi Arabia, visiting the ATLAS experimental cavern with Collaboration Spokesperson P. Jenni and Technical Coordinator M. Nessi.

  13. 12 December 2013 - Sir Konstantin Novoselov, Nobel Prize in Physics 2010, signing the guest book with International Relations Adviser E. Tsesmelis; visiting the ATLAS experimental cavern with Spokesperson D. Charlton; in the LHC tunnel with Technology Department Head F. Bordry. I. Antoniadis, CERN Theory Group Leader, accompanies throughout.

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    12 December 2013 - Sir Konstantin Novoselov, Nobel Prize in Physics 2010, signing the guest book with International Relations Adviser E. Tsesmelis; visiting the ATLAS experimental cavern with Spokesperson D. Charlton; in the LHC tunnel with Technology Department Head F. Bordry. I. Antoniadis, CERN Theory Group Leader, accompanies throughout.

  14. 16 July 2013 - Israel Ministry of Education Director-General D. Stauber in the LHC tunnel at Point 1 with L. Tavian, visiting the ATLAS experimental cavern with Senior Physicist G. Mikenberg; Israeli Delegate to CERN Council E. Rabinovici and CERN Adviser for Israel E. Tsesmelis present; signing the guest book with CERN Director-General R. Heuer.

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    16 July 2013 - Israel Ministry of Education Director-General D. Stauber in the LHC tunnel at Point 1 with L. Tavian, visiting the ATLAS experimental cavern with Senior Physicist G. Mikenberg; Israeli Delegate to CERN Council E. Rabinovici and CERN Adviser for Israel E. Tsesmelis present; signing the guest book with CERN Director-General R. Heuer.

  15. Two new caverns for LHC experiments ATLAS and CMS

    CERN Document Server

    Rammer, H

    1998-01-01

    The LHC will utilize much of the existing infrastructure already constructed for the LEP. However, to house the new ATLAS and CMS detectors, two huge cavern complexes are required at Point 1 and Point 5 on the LEP. The civil engineering design criteria for the two caverns are presented. Attention is directed to the decisive constraints for the design, such as adverse geological ground conditions, the three-dimensional complexity of the shafts, caverns and tunnels, and the existing LEP structures in the vicinity of the new works which remain operational for the first two years of the project. the paper will demonstrate the different basic requirements of the new underground structures at Point 1 and Point 5. The comparison of the two projects from a civil engineering point of view will aim at explaining why different technical solutions have been adopted for the design and construction of these works.

  16. Reinforcement of the concrete base slab of the ATLAS cavern

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    Photo 02: UX15 cavern, preparation for concreting of base slab first lift. Photo 05: UX15 cavern, placing of reinforcement for base slab first lift. Photo 07: UX15 cavern, preparation for concreting of base slab first lift. Photo 09: UX15 cavern, placing of reinforcement for base slab first lift. Photo 10: UX15 cavern, view into PX14 shaft above. Photo 12: UX15 cavern, temporary access platform of RB16 tunnel. Photo 15: UJ17 chamber, invert excavation.

  17. The Armenian minister for trade and economic development Karen Chshmaritian, visited CERN on 4 July and toured the ATLAS experimental cavern and assembly hall

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Armenian Minister for Trade and Economic Development, K. Chshmaritian third from right with from left to right : Aram Kotzinian, JINR, Dubna; Dr Marzio Nessi, ATLAS, Zohrad Mnatsakanian, Ambassador at the Permanent Mission of the Republic of Armenia in Geneva, Karen Chshmaritian, Armenian Minister for Trade and Economic Development, Alexey Sissakian, Vice-Director of JINR and Peter Jenni, ATLAS Spokesperson.

  18. When nearing the ATLAS cavern UX15 through RB16: the TX1S shielding

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Photo 01: 52 tons of ATLAS TX1S shielding with bare hands. Photos 02,03,04: Installation of the second TX1S shielding tube at Point Photos 05,06: Positioning of TX1S shielding, the first ATLAS/LHC interface component to be installed underground. Photo 07: Final adjustment of the TX1S shielding tube at the interface between the LHC tunnel and the ATLAS cavern (UX15).

  19. Second Barrel Toroid Coil Installed in ATLAS Cavern

    CERN Multimedia

    Tappern, G.

    The second barrel toroid coil was lowered into the ATLAS Cavern on Friday, 26 November. The operation takes approximately five hours of precision crane and winch operations. Before lowering, several checks are made to ensure that no loose items have been left on the coil which would fall during the lowering down the shaft. This is a very difficult, but very important check, with the first coil in position, and partly below the shaft. After changing the winch tooling on Wednesday December 1st, the coil was lifted, rotated and placed into the feet. The girders which support the coil and the Z direction stops had all been pre-set before putting the coil in the feet. The angle is controlled by an inclinometer. When the final adjustments of position have been made, which will locate the coils at the plus/minus two mm level, the connection beams (voussoirs and struts) will be put in place; this requires a complex shimming procedure. This will lock together the two coils into the feet and forms the foundation for th...

  20. 21 May 2013 - Greek Minister of Health A. Lykouretzos signing the guest book with CERN Director-General R. Heuer; visiting the LHC tunnel at POint 5 and CMS experimental cavern with Deputy Spokesperson T. Camporesi. CERN-HERMES Network Technical Coordinator E. Dimovasili; Life Sciences Adviser M. Dosanjh; National Contact Physicist, ATLAS Collaboration, NTU, Athens E. Gazis and International Relations Adviser R. Voss accompany the delegation throughout.

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    21 May 2013 - Greek Minister of Health A. Lykouretzos signing the guest book with CERN Director-General R. Heuer; visiting the LHC tunnel at POint 5 and CMS experimental cavern with Deputy Spokesperson T. Camporesi. CERN-HERMES Network Technical Coordinator E. Dimovasili; Life Sciences Adviser M. Dosanjh; National Contact Physicist, ATLAS Collaboration, NTU, Athens E. Gazis and International Relations Adviser R. Voss accompany the delegation throughout.

  1. View of the ATLAS cavern at SX15

    CERN Document Server

    Maximilien Brice

    2003-01-01

    Photo 01: Coactivity in UX15: installation of the cranes and of the metallic structures. Photo 02: The ATLAS HO structure in UX15: a 12 storey metallic frame underground Photo 03: ATLAS giant structures under construction in UX15.

  2. Visits to the ATLAS cavern - A record of 20000 visitors in 2006!

    CERN Multimedia

    Alessandra Ciocio

    The year 2006 closed with the impressive record of just under 20000 visitors to the ATLAS cavern. These visitors come from all walks of life - people within ATLAS, groups from other CERN divisions, retired CERN staff, school groups both from the local area and from far away, companies looking for something different as a special outing, celebrities (Cirque du Soleil, Black Eyed Peas hip-hop group) passing through Geneva who had read Angels and Demons, a stream of VIP visitors and now, more and more, Press visitors. There have been public visits in the ATLAS cavern since the middle of 2003. At that time a lot of the visitors were guided by Bernard Lebegue and Francois Butin. The total number of visits in 2003 was 2220 people. Not bad for just two guides! Over the following three years demand for visits increased to such an extent that the ATLAS Visits Service was created and is now run very successfully under the supervision of Connie Potter in the ATLAS Secretariat in close collaboration with the ever-helpfu...

  3. Sonar atlas of caverns comprising the U.S. Strategic Petroleum Reserve. Volume 3, Bryan Mound Site, Texas.

    Energy Technology Data Exchange (ETDEWEB)

    Rautman, Christopher Arthur; Lord, Anna Snider

    2007-09-01

    Downhole sonar surveys from the four active U.S. Strategic Petroleum Reserve sites have been modeled and used to generate a four-volume sonar atlas, showing the three-dimensional geometry of each cavern. This volume 3 focuses on the Bryan Mound SPR site, located in southeastern Texas. Volumes 1, 2, and 4, respectively, present images for the Bayou Choctaw SPR site, Louisiana, the Big Hill SPR site, Texas, and the West Hackberry SPR site, Louisiana. The atlas uses a consistent presentation format throughout. The basic geometric measurements provided by the down-cavern surveys have also been used to generate a number of geometric attributes, the values of which have been mapped onto the geometric form of each cavern using a color-shading scheme. The intent of the various geometrical attributes is to highlight deviations of the cavern shape from the idealized cylindrical form of a carefully leached underground storage cavern in salt. The atlas format does not allow interpretation of such geometric deviations and anomalies. However, significant geometric anomalies, not directly related to the leaching history of the cavern, may provide insight into the internal structure of the relevant salt dome.

  4. Sonar atlas of caverns comprising the U.S. Strategic Petroleum Reserve. Volume 4, West Hackberry site, Louisiana.

    Energy Technology Data Exchange (ETDEWEB)

    Rautman, Christopher Arthur; Lord, Anna Snider

    2007-09-01

    Downhole sonar surveys from the four active U.S. Strategic Petroleum Reserve sites have been modeled and used to generate a four-volume sonar atlas, showing the three-dimensional geometry of each cavern. This volume 4 focuses on the West Hackberry SPR site, located in southwestern Louisiana. Volumes 1, 2, and 3, respectively, present images for the Bayou Choctaw SPR site, Louisiana, the Big Hill SPR site, Texas, and the Bryan Mound SPR site, Texas. The atlas uses a consistent presentation format throughout. The basic geometric measurements provided by the down-cavern surveys have also been used to generate a number of geometric attributes, the values of which have been mapped onto the geometric form of each cavern using a color-shading scheme. The intent of the various geometrical attributes is to highlight deviations of the cavern shape from the idealized cylindrical form of a carefully leached underground storage cavern in salt. The atlas format does not allow interpretation of such geometric deviations and anomalies. However, significant geometric anomalies, not directly related to the leaching history of the cavern, may provide insight into the internal structure of the relevant salt dome.

  5. Sonar atlas of caverns comprising the U.S. Strategic Petroleum Reserve. Volume 2, Big Hill Site, Texas.

    Energy Technology Data Exchange (ETDEWEB)

    Rautman, Christopher Arthur; Lord, Anna Snider

    2007-08-01

    Downhole sonar surveys from the four active U.S. Strategic Petroleum Reserve sites have been modeled and used to generate a four-volume sonar atlas, showing the three-dimensional geometry of each cavern. This volume 2 focuses on the Big Hill SPR site, located in southeastern Texas. Volumes 1, 3, and 4, respectively, present images for the Bayou Choctaw SPR site, Louisiana, the Bryan Mound SPR site, Texas, and the West Hackberry SPR site, Louisiana. The atlas uses a consistent presentation format throughout. The basic geometric measurements provided by the down-cavern surveys have also been used to generate a number of geometric attributes, the values of which have been mapped onto the geometric form of each cavern using a color-shading scheme. The intent of the various geometrical attributes is to highlight deviations of the cavern shape from the idealized cylindrical form of a carefully leached underground storage cavern in salt. The atlas format does not allow interpretation of such geometric deviations and anomalies. However, significant geometric anomalies, not directly related to the leaching history of the cavern, may provide insight into the internal structure of the relevant salt dome.

  6. Sonar atlas of caverns comprising the U.S. Strategic Petroleum Reserve. Volume 1, Bayou Choctaw site, Louisiana.

    Energy Technology Data Exchange (ETDEWEB)

    Rautman, Christopher Arthur; Lord, Anna Snider

    2007-10-01

    Downhole sonar surveys from the four active U.S. Strategic Petroleum Reserve sites have been modeled and used to generate a four-volume sonar atlas, showing the three-dimensional geometry of each cavern. This volume 1 focuses on the Bayou Choctaw SPR site, located in southern Louisiana. Volumes 2, 3, and 4, respectively, present images for the Big Hill SPR site, Texas, the Bryan Mound SPR site, Texas, and the West Hackberry SPR site, Louisiana. The atlas uses a consistent presentation format throughout. The basic geometric measurements provided by the down-cavern surveys have also been used to generate a number of geometric attributes, the values of which have been mapped onto the geometric form of each cavern using a color-shading scheme. The intent of the various geometrical attributes is to highlight deviations of the cavern shape from the idealized cylindrical form of a carefully leached underground storage cavern in salt. The atlas format does not allow interpretation of such geometric deviations and anomalies. However, significant geometric anomalies, not directly related to the leaching history of the cavern, may provide insight into the internal structure of the relevant salt dome.

  7. Prof. Jean-Dominique Vassalli, Rector of University of Geneva visiting the cavern ATLAS, the control room of ATLAS and the machine LHC at Point 1 with Collaboration Spokesperson P. Jenni and Dr. Jos Engelen, Chief Scientific Officer of CERN.

    CERN Multimedia

    Maximilien Brice

    2008-01-01

    Prof. Jean-Dominique Vassalli, Rector of University of Geneva visiting the cavern ATLAS, the control room of ATLAS and the machine LHC at Point 1 with Collaboration Spokesperson P. Jenni and Dr. Jos Engelen, Chief Scientific Officer of CERN.

  8. Dedication of the massive ATLAS art mural painted by Josef Kristofoletti directly above the cavern of the ATLAS Experiment at CERN

    CERN Multimedia

    Claudia Marcelloni, Michael Barnett

    2010-01-01

    Ceremony to celebrate the massive mural of the ATLAS detector at CERN painted by artist Josef Kristofoletti. The mural is located at the ATLAS Experiment site, and it shows on two perpendicular walls the detector with a collision event superimposed. The event on the large wall shows a simulation of an event that would be recorded in ATLAS if a Higgs boson was produced. The cavern of the ATLAS Experiment with the detector is 100 meters directly below the mural. The height of the mural is about 12 meters (40 feet). The actual ATLAS detector is more than twice as big.

  9. The Asian earthquakes detected in the ATLAS cavern

    CERN Multimedia

    2005-01-01

    At the end of December, mysterious vibrations were picked up by the deformation sensors under the feet that are to support the ATLAS detector. It transpired that they had detected waves produced by the earthquakes responsible for the terrible tsunami in Asia.

  10. Major clean-up effort in the ATLAS cavern

    CERN Multimedia

    Marzio Nessi

    On Tuesday 10 October, 58 ATLAS collaborators volunteered to give a hand for a major clean-up of the ATLAS detector prior to the toroid magnet ramp-up. This special task monopolised all of the technical coordination team and eight supervisors to oversee the volunteers who were assigned to two separate five-hour shifts. The volunteers removed all sorts of loose material inside and outside the detector, focusing mainly on potentially magnetic material lost inside the detector and dirt accumulated over several months, not to mention zillions of clipped cable ties! The technical crew provided 120 garbage bags and all were used. All sorts of material that had been lost inside the detector by various people was retrieved, in particular small tools which could potentially damage the detector, as well as metallic fillings hazardous for the electronics once the magnet will be ramped up. A more detailed inspection followed for all the inside of the detector, making sure the current on the magnet could be raised to 5KA ...

  11. Study of the ventilation at ATLAS cavern UX15 air velocity and temperature around the muon chambers

    CERN Document Server

    Vigo-Castellví, E

    2000-01-01

    The Muon Chambers of ATLAS detector cannot work under temperature differences between two opposed faces above 3 K. In addition, a low velocity of the air around the Muon Chambers is essential to avoid vibration problems. The CV group at the ST division is involved in an airflow simulation inside UX15 cavern to check air temperature and velocity profiles around the ATLAS Muon Chambers. In this paper, the status and the content of the performed theoretical studies will be explained. Three simulation models, which helped to understand the Muon Spectrometer thermal environment and the efficiency of the ventilation system at ATLAS cavern, will be presented. Besides, it will be shown how these studies support the proposal of a deeper individual Muon Chamber study.

  12. Views of the ATLAS experimental hall

    CERN Multimedia

    Maximilien Brice

    2005-01-01

    The shell of the ATLAS detector is seen from many angles within its cavernous underground hall. All of the eight huge toroid magnets have been installed and fixed in place. The core of the detector, the largest of its type in the world, will soon be filled with many different detector-elements to observe the results of proton-proton collisions at the LHC when it is turned on in 2008.

  13. Transporting the first ATLAS toroid

    CERN Multimedia

    Maximilien Brice

    2004-01-01

    The first coil for the ATLAS toroid magnet is transported from its assembly hall at the CERN Meyrin site to the storage hall above the ATLAS cavern. This involves driving the massive transportation vehicle first through the Meyrin site and then across a main road only metres from the France-Swiss border. Eight magnets in total will be transported in this way before being lowered into the experimental cavern where they will be mounted in a huge ring surrounding the detector.

  14. 18 MArch 2008 - Director, Basic and Generic Research Division, Research Promotion Bureau, Japanese Ministry of Education, Culture, Sports, Science and Technology Prof.Ohtake visiting ATLAS cavern with Spokesperson P. Jenni.

    CERN Document Server

    Maximilien Brice

    2008-01-01

    18 MArch 2008 - Director, Basic and Generic Research Division, Research Promotion Bureau, Japanese Ministry of Education, Culture, Sports, Science and Technology Prof.Ohtake visiting ATLAS cavern with Spokesperson P. Jenni.

  15. His Excellency Mr Valery Loshchinin Extraordinary and plenipotentiary Ambassador Permanent Representative of the Russian Federation to the United Nations Office in Geneva visit the ATLAS experiment in the cavern at Point 1 introducted by Prof. Peter Jenni.

    CERN Document Server

    Maximilien Brice

    2007-01-01

    His Excellency Mr Valery Loshchinin Extraordinary and plenipotentiary Ambassador Permanent Representative of the Russian Federation to the United Nations Office in Geneva visit the ATLAS experiment in the cavern at Point 1 introducted by Prof. Peter Jenni.

  16. 15 April 2008 - British Minister for Science and Innovation I. Pearson MP visiting the ATLAS cavern with Adviser to CERN Director-General J. Ellis, Ambassador to Switzerland S. Featherstone and Collaboration Spokesperson P. Jenni

    CERN Multimedia

    Claudia Marcelloni

    2008-01-01

    15 April 2008 - British Minister for Science and Innovation I. Pearson MP visiting the ATLAS cavern with Adviser to CERN Director-General J. Ellis, Ambassador to Switzerland S. Featherstone and Collaboration Spokesperson P. Jenni

  17. March 2008 - ITER Organization Director-General K.Ikeda and Deputy Director-General N. Holtkamp, visiting the ATLAS cavern with Spokesperson P. Jenni, Accelerators Technology Department Head P. Lebrun and LHC Mangnets Group Leader L. Rossi.

    CERN Multimedia

    Claudia Marcelloni

    2008-01-01

    March 2008 - ITER Organization Director-General K.Ikeda and Deputy Director-General N. Holtkamp, visiting the ATLAS cavern with Spokesperson P. Jenni, Accelerators Technology Department Head P. Lebrun and LHC Mangnets Group Leader L. Rossi.

  18. Dr Mauro Dell’Ambrogio, State Secretary for Education and Research of the Swiss Confederation visit the ATLAS Cavern and the LHC Machine with with Collaboration Spokesperson P. Jenni and Technical Coordinator M. Nessi.

    CERN Multimedia

    Maximilien Brice

    2008-01-01

    Dr Mauro Dell’Ambrogio, State Secretary for Education and Research of the Swiss Confederation visit the ATLAS Cavern and the LHC Machine with with Collaboration Spokesperson P. Jenni and Technical Coordinator M. Nessi.

  19. Limestone Caverns

    Science.gov (United States)

    Powell, Richard L.

    1970-01-01

    Describes the origin of limestone caverns, using Mammoth Cave as an example, with particular reference to the importance of groundwater information of caverns, the present condition of groundwater, and how caverns develop within fluctuating groundwater zones. (BR)

  20. ATLAS: civil engineering Point 1

    CERN Multimedia

    Jean-Claude Vialis

    2000-01-01

    The ATLAS experimental area is located in Point 1, just across the main CERN entrance, in the commune of Meyrin. There people are busy to finish the different infrastructures for ATLAS. Real underground video. Nice view from the surface to the cavern from the pit side - all the big machines looked very small. The film has original working sound.

  1. 18 December 2012 - British University of Edinburgh Principal T. O’Shea and delegation (see list below) visiting the CERN Control Centre with Beams Department D. Nisbet, the LHC superconducting magnet test hall with Beams Department R. Veness, in the ATLAS Visitor Centre and experimental cavern with Collaboration Spokesperson F. Gianotti, in LHCb experimental cavern with Collaboration Spokesperson P. Campana and signing the guest book with CERN Director-General R. Heuer

    CERN Multimedia

    Jean-Claude Gadmer

    2012-01-01

    The delegation was throughout accompanied by Beams Department R. Veness and Physics Department and ATLAS Collaboration P. Wells 1.\tProf. Sir Timothy O'Shea, Principal, University of Edinburgh 2.\tProf. Lesley Yellowlees, Vice Principal, Head of College of Science and Engineering 3.\tProf Jeff Haywood, Vice Principal for Knowledge Management 4.\tProf. Peter Higgs, Professor of Theoretical Physics 5.\tMr Bruce Minto, Supporter of the University 6.\tProf. Walter Nimmo, Supporter of the University 7.\tProf. Arthur Trew, Head of School of Physics and Astronomy 8.\tProf David Robertson, Head of School of Informatics 9.\tProf Stefano Brandani, Head of School of Engineering 10.\tMr Alan Walker, accompanying Prof. Higgs 11.\tProf. Peter Clarke, LHCb Collaboration, School of Physics and Astronomy

  2. ATLAS cavern hand-over ceremony on 4th June 2003 in the presence of the President of the Swiss Confederation

    CERN Multimedia

    Jenni, P

    The 4th of June 2003 will be remembered as a very major milestone in the history of the ATLAS detector construction. In the presence of the President of the Swiss Confederation, Mr. Pascal Couchepin, the ATLAS cavern was handed over by the CERN Director-General, Professor Luciano Maiani, to the Collaboration. For this highly press-mediated event the CERN Director-General had invited some 100 political personalities and representatives from the Geneva and the neighbouring French regions, and from CERN Member and Non-Member States. The surface building was transformed for this occasion into an attractive multi- media hall with films and exhibitions from ATLAS and the civil engineering, with a bar and the CERN jazz band. Besides of course the cavern itself, the Swiss President visited also the ATLAS barrel toroid magnet and the LAr calorimeter assembly activities in Hall 180. The Swiss President visiting the Barrel Toroid integration work in Hall 180 He was very interested and impressed by these, aski...

  3. ATLAS Tile Calorimeter extended barrel side C, assembly and installation in the cavern.

    CERN Multimedia

    Nikolai Topilin

    2009-01-01

    These photos belong to the self-published book by Nikolai Topilin "ATLAS Hadron Calorimeter Assembly". The book is a collection of souvenirs from the years of assembly and installation of the Tile Hadron Calorimeter, which extended from November 2002 until May 2006.

  4. ATLAS Tile Calorimeter extended barrel Side A assembly and installation in the cavern.

    CERN Multimedia

    Nikolai Topilin

    2009-01-01

    These photos belong to the self-published book by Nikolai Topilin "ATLAS Hadron Calorimeter Assembly". The book is a collection of souvenirs from the years of assembly and installation of the Tile Hadron Calorimeter, which extended from November 2002 until May 2006.

  5. Senior Senator from Florida and Chairman, Senate Committee on Space, Aeronautics and Related Sciences W. Nelson, visiting the ATLAS cavern and LHC tunnel with ATLAS Collaboration Spokesperson P. Jenni and AMS Collaboration Spokesperson S.C.C.Ting, 16 March 2008.

    CERN Multimedia

    Maximilien Brice

    2008-01-01

    Senior Senator from Florida and Chairman, Senate Committee on Space, Aeronautics and Related Sciences W. Nelson, visiting the ATLAS cavern and LHC tunnel with ATLAS Collaboration Spokesperson P. Jenni and AMS Collaboration Spokesperson S.C.C.Ting, 16 March 2008.

  6. Tuesday 28 January 2014 - K. E. Huthmacher Ministerialdirektor Provision for the Future - Basic and Sustainability Research Federal Ministry of Education and Research (BMBF) visiting the stands with R. Heuer CERN Director-General on the occasion of the Inauguration of the Industrial Exhibition Germany@CERN and visiting the ATLAS Cavern with D. Charlton ATLAS Collaboration Spokesperson and R. Voss Head of International Relations.

    CERN Multimedia

    Pantelia, Anna

    2014-01-01

    Tuesday 28 January - K. E. Huthmacher Ministerialdirektor Provision for the Future - Basic and Sustainability Research Federal Ministry of Education and Research (BMBF) visiting the stands with R. Heuer CERN Director-General on the occasion of the Inauguration of the Industrial Exhibition Germany@CERN and visiting the ATLAS Cavern with D. Charlton ATLAS Collaboration Spokesperson and R. Voss Head of International Relations.

  7. Mr Lars Leijonborg, Minister for Higher Education and Research of Sweden visiting the cavern ATLAS, the control room of ATLAS and the machine LHC at Point 1 with Collaboration Spokesperson P. Jenni and Dr. Jos Engelen, Chief Scientific Officer of CERN.

    CERN Multimedia

    Maximilien Brice

    2008-01-01

    Mr Lars Leijonborg, Minister for Higher Education and Research of Sweden visiting the cavern ATLAS, the control room of ATLAS and the machine LHC at Point 1 with Collaboration Spokesperson P. Jenni and Dr. Jos Engelen, Chief Scientific Officer of CERN.

  8. 16 December 2013 - P. Lavie President of the Technion Institute of Technology in Israel visiting the ATLAS cavern with ATLAS Deputy Spokesperson T. Wengler; visiting the LHC tunnel at Point 1 with Technology Department Head F. Bordry and signing the Guest Book with CERN Director-General R. Heuer. G. Mikenberg, E. Rabinovici, Y. Rozen and S. Tarem present throughout.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    16 December 2013 - P. Lavie President of the Technion Institute of Technology in Israel visiting the ATLAS cavern with ATLAS Deputy Spokesperson T. Wengler; visiting the LHC tunnel at Point 1 with Technology Department Head F. Bordry and signing the Guest Book with CERN Director-General R. Heuer. G. Mikenberg, E. Rabinovici, Y. Rozen and S. Tarem present throughout.

  9. 5 June 2013 - European Union Ambassador to Switzerland and the Principality of Liechtenstein R. Jones in the ATLAS cavern with ATLAS Collaboration Deputy Spokesperson T. Wengler, in the LHC tunnel at Point 1 with Technology Department Head F. Bordry and signing the guest book with Director-General R. Heuer. Head of the EU Projects Office S. Stavrev present.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    5 June 2013 - European Union Ambassador to Switzerland and the Principality of Liechtenstein R. Jones in the ATLAS cavern with ATLAS Collaboration Deputy Spokesperson T. Wengler, in the LHC tunnel at Point 1 with Technology Department Head F. Bordry and signing the guest book with Director-General R. Heuer. Head of the EU Projects Office S. Stavrev present.

  10. 17 October 2013 - C. Ashton High Representative of the European Union for Foreign Affairs and Security Policy, Vice-President of the European Commission visiting the ATLAS cavern with ATLAS Collaboration Spokesperson D. Charlton; visiting the LHC tunnel at Point 1 with Technology Department Head F. Bordry and signing the Guest book with CERN Director-General R. Heuer.

    CERN Multimedia

    Maximilien Brice

    2013-01-01

    17 October 2013 - C. Ashton High Representative of the European Union for Foreign Affairs and Security Policy, Vice-President of the European Commission visiting the ATLAS cavern with ATLAS Collaboration Spokesperson D. Charlton; visiting the LHC tunnel at Point 1 with Technology Department Head F. Bordry and signing the Guest book with CERN Director-General R. Heuer.

  11. 17 April 2008 - Head of Internal Audit Network meeting visiting the ATLAS experimental area with CERN ATLAS Team Leader P. Fassnacht, ATLAS Technical Coordinator M. Nessi and ATLAS Resources Manager M. Nordberg.

    CERN Multimedia

    Mona Schweizer

    2008-01-01

    17 April 2008 - Head of Internal Audit Network meeting visiting the ATLAS experimental area with CERN ATLAS Team Leader P. Fassnacht, ATLAS Technical Coordinator M. Nessi and ATLAS Resources Manager M. Nordberg.

  12. Preparing an ATLAS toroid magnet end-cap for lowering

    CERN Multimedia

    Claudia Marcelloni

    2007-01-01

    One of the two 13-m high toroid magnet end-caps for the ATLAS experiment being transported from the construction hall to the experimental area. The end-cap will be lowered into the ATLAS cavern and attached to an end of the detector.

  13. 10 September 2013 - Italian Minister for Economic Development F. Zanonato visiting the ATLAS cavern with Collaboration Spokesperson D. Charlton and Italian scientists F. Gianotti and A. Di Ciaccio; signing the guest book with CERN Director-General R. Heuer and Director for Research and Scientific Computing S. Bertolucci; in the LHC tunnel with S. Bertolucci, Technology Deputy Department Head L. Rossi and Engineering Department Head R. Saban; visiting CMS cavern with Scientists G. Rolandi and P. Checchia.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    10 September 2013 - Italian Minister for Economic Development F. Zanonato visiting the ATLAS cavern with Collaboration Spokesperson D. Charlton and Italian scientists F. Gianotti and A. Di Ciaccio; signing the guest book with CERN Director-General R. Heuer and Director for Research and Scientific Computing S. Bertolucci; in the LHC tunnel with S. Bertolucci, Technology Deputy Department Head L. Rossi and Engineering Department Head R. Saban; visiting CMS cavern with Scientists G. Rolandi and P. Checchia.

  14. 1er février 2011-Première Présidente de la Confédération Suisse (1999)-Mme Ruth Dreifuss-Visite de la caverne expérimentale d’ATLAS avec F. Pauss, Chef des Relations internationales

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    Photo 1-24:Collaboration ATLAS, Ancien Porte-parole P. Jenni+F. Pauss+Experte en pédagogie S. Forster+R. Dreifuss+C. Bossy+JP Bossy, visite de la caverne ATLAS Photo 25-40:Visite du Tunnel LHC au Point 1

  15. Construction, assembly and testing of the ATLAS hadronic end-cap calorimeter

    CERN Document Server

    Gingrich, D M; Pinfold, J L; Soukup, J; Axen, D; Cojocaru, C; Oakham, G; O'Neill, M; Vincter, M G; Aleksa, M; Bremer, J; Chalifour, M; Fabre, C; Fassnacht, P; Gonidec, A; Pailler, P; Vandoni, G; Cheplakov, A; Datskov, V; Drobin, V; Fedorov, A; Golubykh, S; Javadov, N; Kalinnikov, V; Kakurin, S; Kazarinov, M; Kukhtin, V; Ladygin, E; Lazarev, A; Neganov, A; Pisarev, I; Rousakovitch, N; Serochkin, E; Shilov, S N; Shalyugin, A N; Usov, Yu; Bán, J; Bruncko, D; Kladiva, E; Stavina, P; Strízenec, P; Heldmann, M; Hohlfeld, M; Jakobs, K; Köpke, L; Marschalkowski, E; Meder, D; Othegraven, R; Schäfer, U; Schroff, D; Secker, H; Thomas, J; Walkowiak, W; Zeitnitz, C; Azuelos, Georges; Delsart, P-A; Leroy, C; Mazini, R; Mehdiyev, R; Akimov, A; Blagov, M; Komar, A; Snesarev, A; Speransky, M N; Sulin, V; Yakimenko, M; Aderholz, M; Barillari, T; Brettel, H; Cwienk, W; Fent, J; Fischer, A; Habring, J; Huber, J; Karev, A; Kiryunin, A E; Kurchaninov, L; Laskus, H; Menke, S; Mooshofer, P; Oberlack, H; Salihagic, D; Schacht, P; Schmücker, H; Stenzel, H; Striegel, D; Tribanek, W; Zimmer, J; Chen, T; Ping, J; Qi, M; Falou, A; Mace, G; Chekulaev, S V; Denisov, S; Levitsky, M; Minaenko, A; Mitrofanov, G Ya; Moiseev, A; Pleskatch, A; Sytnik, V V; Zakamsky, L; Benoit, P; Hoyle, K W; Honma, A; Losty, M J; Maharaj, R; Oram, C J; Pattyn, E W; Rosvick, M; Sbarra, C; Wellisch, H P; Wielers, M; Birney, P S; Dobbs, M; Fincke-Keeler, M; Fortin, D; Hodges, T A; Ince, T; Kanaya, N; Keeler, R K; Langstaf, R; Lefebvre, M; McPherson, R A; O'Neil, D C; Seuster, R; Forbush, D; Mockett, P; Toevs, F; Braun, H M

    2007-01-01

    The construction and assembly of the four wheels of the ATLAS hadronic end-cap calorimeter and their insertion into the two end-cap cryostats are described. The results of the qualification tests prior to installation of the two cryostats in the ATLAS experimental cavern are reviewed.

  16. 19 September 2012 - Indonesian Members of Parliament visiting the CMS control room and experimental cavern at Point 5 with Former Deputy Spokesperson A. De Roeck and International Relations Adviser E. Tsesmelis.

    CERN Multimedia

    Jean-Claude Gadmer

    2012-01-01

    19 September 2012 - Indonesian Members of Parliament visiting the CMS control room and experimental cavern at Point 5 with Former Deputy Spokesperson A. De Roeck and International Relations Adviser E. Tsesmelis.

  17. Digging a cavern for a titan

    CERN Multimedia

    Patrice Loiez

    1999-01-01

    Civil engineers work 100 m underground near the France-Swiss border on the cavern that will soon house ATLAS, one of the experiments on CERN's new LHC accelerator. All personnel and equipment must be lowered by crane down the access shaft. When completed this cavern will have one of the largest spans constructed at 35 m, which required the roof to be supported by large steel anchors buried in concrete.

  18. 31st January 2011 - OECD Secretary-General A. Gurría visiting the ATLAS underground experimental area with Former Collaboration Spokesperson P. Jenni.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    CERN-HI-1101036 21. Former ATLAS Collaboration Spokesperson P. Jenni, Counsellor for Scientific Affairs S. Michalowski, Secretary General Chief of Staff G. Ramos, OECD Secretary-General A. Gurría, Relations with International Organisations M. Bona, Head of International Relations F. Pauss and Director M. Oborne, in the ATLAS cavern.

  19. 28 November 2013 - N. N. Kudryavtsev, Russian Rector of the Moscow Institute of Physics and Technology signing an Agreement and the Guest Book with CERN Director-General R. Heuer; visiting the ATLAS cavern with ATLAS Deputy Spokesperson B. Heinemann and visiting the LHC tunnel at Point 1 with AGH University of Science and Technology A. Erokhin. M. Savino, Physics Department, Joint Institute for Nuclear Research also present.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    28 November 2013 - N. N. Kudryavtsev, Russian Rector of the Moscow Institute of Physics and Technology signing an Agreement and the Guest Book with CERN Director-General R. Heuer; visiting the ATLAS cavern with ATLAS Deputy Spokesperson B. Heinemann and visiting the LHC tunnel at Point 1 with AGH University of Science and Technology A. Erokhin. M. Savino, Physics Department, Joint Institute for Nuclear Research also present.

  20. 17th April 2008 - W. W. Tichenor, Ambassador, Permanent Representative of the United States of America to the United Nations Office and other international organisations in Geneva visiting the ATLAS cavern with Collaboration Spokesperson P. Jenni and AMS Collaboration Spokesperson S.C.C.Ting.

    CERN Multimedia

    Maximilien Brice

    2008-01-01

    17th April 2008 - W. W. Tichenor, Ambassador, Permanent Representative of the United States of America to the United Nations Office and other international organisations in Geneva visiting the ATLAS cavern with Collaboration Spokesperson P. Jenni and AMS Collaboration Spokesperson S.C.C.Ting.

  1. 4th July 2011 - Russian Deputy Director-General Director of Directorate for Scientific and Technical Complex ROSATOM V. Pershukov in the ATLAS underground experimental area with Adviser T. Kurtyka, ATLAS Technical Coordinator M. Nessi and ATLAS Russian users.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    4th July 2011 - Russian Deputy Director-General Director of Directorate for Scientific and Technical Complex ROSATOM V. Pershukov in the ATLAS underground experimental area with Adviser T. Kurtyka, ATLAS Technical Coordinator M. Nessi and ATLAS Russian users.

  2. Cavernous nerve reconstitution with the use of bone marrow stem cells and erectile function evaluation: an experimental animal study

    Directory of Open Access Journals (Sweden)

    Oskar Grau Kaufmann

    2009-12-01

    Full Text Available Objective: To assess the influence of adult stem cells from bone marrow of rats in the regeneration of cavernous nerve, taking the return of erectile function as a parameter in animals subjected to the apomorphine-induced test of erection. Methods: Forty-eight male Wistar-EPM rats, aged between nine and ten weeks, and weighing approximately 250 g were used. They were randomly divided into four study Groups containing 12 animals each, as follows: Group I: surgical exposure of the cavernous nerves bilaterally without injury; Group II: bilateral surgical injury of the cavernous nerve of approximately 3 mm, without reconstruction; Group III: bilateral surgical injury of the cavernous nerves of approximately 3 mm, and bilateral reconstruction with silicone guiding tubes containing saline solution inside; Group IV: bilateral surgical injury of the cavernous nerves of approximately 3 mm, and bilateral reconstruction with silicone guiding tubes filled with adult stem cells. Four weeks after surgery, the animals were injected with apomorphine for induction of erection. Rresults: In Group I there was complete erectile response in all animals (100% – 12 out of 12. On the other hand, none of the animals in Group II presented erection after the use of apomorphine. Five of the twelve animals of Group III (41.7% and nine of the 12 animals of Group IV (75% had erections after the stimulus. When we compared the frequency of restoration of erection in the four Groups, Group IV was shown to have a similar performance to Group I (p = 0.217, while Group III animals had a frequency of erections inferior to those in Group I (p = 0.005. Moreover, comparison of results of Groups III and IV versus Group II showed that the frequency of erections was statistically higher in the first two Groups (p = 0.037 and p < 0.001, respectively. Finally, Group IV presented a tendency to a larger number of erections when compared to Group III (75 versus 41.7% but this difference was

  3. 28th January 2011-Vice-President Max Planck Society-Prof. Martin Stratmann-Germany-visiting the ATLAS experimental area and the LHC Tunnel at CERN

    CERN Multimedia

    Jean-Claude Gadmer

    2011-01-01

    Photo 1:ATLAS visitor Center with P. Jenni, ATLAS Collaboration former spokesperson Photo 2-10:visiting the ATLAS cavern Photo 10:D. Hoppe,P. Jenni,M. Stratmann,S. Bethke,S. Braun,D. Klammer Photo 11-15:visiting the LHC tunnel Photo 16-18:Signature of the Guest Book with S. Lettow,Director for Administration and General Infrastructure

  4. Supporting ATLAS

    CERN Multimedia

    maximilien brice

    2003-01-01

    Eighteen feet made of stainless steel will support the barrel ATLAS detector in the cavern at Point 1. In total, the ATLAS feet system will carry approximately 6000 tons, and will give the same inclination to the detector as the LHC accelerator.

  5. Cavernous sinus thrombosis

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/001628.htm Cavernous sinus thrombosis To use the sharing features on this page, please enable JavaScript. Cavernous sinus thrombosis is a blood clot in an ...

  6. Experimental evaluation of job provenance in ATLAS environment

    Science.gov (United States)

    Křenek, A.; Sitera, J.; Chudoba, J.; Dvořák, F.; Filipovič, J.; Kmuníček, J.; Matyska, L.; Mulaš, M.; Ruda, M.; Šustr, Z.; Campana, S.; Molinari, E.; Rebatto, D.

    2008-07-01

    Grid middleware stacks, including gLite, matured into the state of being able to process up to millions of jobs per day. Logging and Bookkeeping, the gLite job-tracking service, keeps pace with this rate; however, it is not designed to provide a long-term archive of information on executed jobs. ATLAS — representative of a large user community — addresses this issue with its own job catalogue (ProdDB). Development of such a customized service, not easily reusable, took considerable effort which is not affordable by smaller communities. On the contrary, Job Provenance (JP), a generic gLite service designed for long-term archiving of information on executed jobs focusing on scalability, extensibility, uniform data view, and configurability, allows more specialized catalogues to be easily built. We present the first results of an experimental JP deployment for the ATLAS production infrastructure where a JP installation was fed with a part of ATLAS jobs, and also stress tested with real production data. The main outcome of this work is a demonstration that JP can complement large-scale application-specific job catalogue services, while serving a similar purpose where there are none available.

  7. First ATLAS Events Recorded Underground

    CERN Multimedia

    Teuscher, R

    As reported in the CERN Bulletin, Issue No.30-31, 25 July 2005 The ATLAS barrel Tile calorimeter has recorded its first events underground using a cosmic ray trigger, as part of the detector commissioning programme. This is not a simulation! A cosmic ray muon recorded by the barrel Tile calorimeter of ATLAS on 21 June 2005 at 18:30. The calorimeter has three layers and a pointing geometry. The light trapezoids represent the energy deposited in the tiles of the calorimeter depicted as a thick disk. On the evening of June 21, the ATLAS detector, now being installed in the underground experimental hall UX15, reached an important psychological milestone: the barrel Tile calorimeter recorded the first cosmic ray events in the underground cavern. An estimated million cosmic muons enter the ATLAS cavern every 3 minutes, and the ATLAS team decided to make good use of some of them for the commissioning of the detector. Although only 8 of the 128 calorimeter slices ('superdrawers') were included in the trigg...

  8. The PowerAtlas: a power and sample size atlas for microarray experimental design and research

    Directory of Open Access Journals (Sweden)

    Wang Jelai

    2006-02-01

    Full Text Available Abstract Background Microarrays permit biologists to simultaneously measure the mRNA abundance of thousands of genes. An important issue facing investigators planning microarray experiments is how to estimate the sample size required for good statistical power. What is the projected sample size or number of replicate chips needed to address the multiple hypotheses with acceptable accuracy? Statistical methods exist for calculating power based upon a single hypothesis, using estimates of the variability in data from pilot studies. There is, however, a need for methods to estimate power and/or required sample sizes in situations where multiple hypotheses are being tested, such as in microarray experiments. In addition, investigators frequently do not have pilot data to estimate the sample sizes required for microarray studies. Results To address this challenge, we have developed a Microrarray PowerAtlas 1. The atlas enables estimation of statistical power by allowing investigators to appropriately plan studies by building upon previous studies that have similar experimental characteristics. Currently, there are sample sizes and power estimates based on 632 experiments from Gene Expression Omnibus (GEO. The PowerAtlas also permits investigators to upload their own pilot data and derive power and sample size estimates from these data. This resource will be updated regularly with new datasets from GEO and other databases such as The Nottingham Arabidopsis Stock Center (NASC. Conclusion This resource provides a valuable tool for investigators who are planning efficient microarray studies and estimating required sample sizes.

  9. 29 August 2013 - J.-F. Jauslin, Directeur de l’Office fédéral de la culture (OFC) Ambassadeur suisse auprès de l’UNESCO et de l’OIF au 1er septembre 2013 Confédération suisse visite le centre visiteurs de l’expérience ATLAS ainsi que la caverne expérimentale d'ATLAS avec P. Jenny, ancien Porte-parole d'ATLAS. M. Bona, Conseiller du Directeur général pour les relations avec les Organisations internationales présent tout au long.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    29 August 2013 - J.-F. Jauslin, Directeur de l’Office fédéral de la culture (OFC) Ambassadeur suisse auprès de l’UNESCO et de l’OIF au 1er septembre 2013 Confédération suisse visite le centre visiteurs de l’expérience ATLAS ainsi que la caverne expérimentale d'ATLAS avec P. Jenny, ancien Porte-parole d'ATLAS. M. Bona, Conseiller du Directeur général pour les relations avec les Organisations internationales présent tout au long.

  10. Experimental limits from ATLAS on Standard Model Higgs production.

    CERN Multimedia

    ATLAS, collaboration

    2012-01-01

    Experimental limits from ATLAS on Standard Model Higgs production in the mass range 110-600 GeV. The solid curve reflects the observed experimental limits for the production of a Higgs of each possible mass value (horizontal axis). The region for which the solid curve dips below the horizontal line at the value of 1 is excluded with a 95% confidence level (CL). The dashed curve shows the expected limit in the absence of the Higgs boson, based on simulations. The green and yellow bands correspond (respectively) to 68%, and 95% confidence level regions from the expected limits. Higgs masses in the narrow range 123-130 GeV are the only masses not excluded at 95% CL

  11. Experimental biological effects assessment associated with on-shore brine discharge from the creation of gas storage caverns

    Science.gov (United States)

    Quintino, Victor; Rodrigues, Ana Maria; Freitas, Rosa; Ré, Ana

    2008-09-01

    Most of the studies on biological and ecological effects associated with brine discharge into the marine environment are related to the operation of desalination plants, for the production of freshwater. In this study we analysed the biological effects of a brine effluent from a completely different source, produced from the lixiviation of rock salt caves, for the creation of natural gas storage caverns. Lethal and sub-lethal endpoints following exposure to the brine were studied in a range of macrofauna species characteristic of the soft and hard bottom habitats in the vicinity of the discharge area, namely the isopod Eurydice pulchra, the annelids Sabellaria alveolata and Ophelia radiata, the sea-urchin Paracentrotus lividus and the bivalve Mytilus galloprovincialis. In a first series of experiments, brine, with salinity above 300, was diluted in distilled water to a salinity value close to that of the seawater in the discharge area (salinity 36) and, surprisingly, none of the exposed species was able to survive or develop into viable larvae. A second series of experiments exposed the species to brine diluted with seawater, simulating more realistic discharge circumstances. All the tested species at all the measured endpoints (adult survival, larval abnormal development, sperm fertilization success) showed negative biological effects in brine solutes always at a lower salinity than that of a salinity control obtained with concentrated seawater. The sub-lethal experiments with larval development of P. lividus, S. alveolata and M. galloprovincialis, and the fertilization success of P. lividus gave EC 50 values for the brine solute with salinity in the range of 40.9-43.5, whereas the EC 50 values for the concentrated seawater were in the range of salinity 44.2-49.0. It is hypothesised that differences in the ionic composition of the brine cause the inability of the species to tolerate the exposure to brine.

  12. ATLAS: last few metresfor the Calorimeter

    CERN Multimedia

    2005-01-01

    On Friday 4th November, the ATLAS Barrel Calorimeter was moved from its assembly point at the side of the ATLAS cavern to the centre of the toroidal magnet system. The detector was finally aligned, to the precision of within a millimetre, on Wednesday 9th November. The ATLAS installation team, led by Tommi Nyman, after having positioned the Barrel Calorimeter in its final location in the ATLAS experimental cavern UX15. The Barrel Calorimeter which will absorb and measure the energy of photons, electrons and hadrons at the core of the ATLAS detector is 8.6 meters in diameter, 6.8 meters long, and weighs over 1600 Tonnes. It consists of two concentric cylindrical detector elements. The innermost comprises aluminium pressure vessels containing the liquid argon electromagnetic calorimeter and the solenoid magnet. The outermost is an assembly of 64 hadron tile calorimeter sectors. Assembled 18 meters away from its final position, the Barrel Calorimeter was relocated with the help of a railway, which allows the ...

  13. Evoked cavernous activity.

    Science.gov (United States)

    Yilmaz, Uğur; Soylu, Ahmet; Ozcan, Cemal; Kutlu, Ramazan; Güneş, Ali

    2002-01-01

    Corpus cavernosum electromyography has been widely done to evaluate autonomic dysfunction in patients with erectile dysfunction. We assessed the value of corpus cavernosum electromyography, evoked cavernous activity and penile sympathetic skin responses for their accuracy in determining autonomic involvement in cases of erectile dysfunction. We evaluated 75 men with erectile dysfunction by corpus cavernosum electromyography, evoked cavernous activity and penile sympathetic skin response tests at our neurourology laboratory. The etiology of dysfunction was vascular, neurogenic, psychogenic or mixed based on a detailed medical and sexual history, physical examination, electrophysiological and laboratory studies, penile color Doppler ultrasonography, and cavernosography and/or cavernosometry. Autonomic involvement was clinically assessed by systemic findings, such as orthostatic hypotension, impaired gastrointestinal motility, sinus dysrhythmia and secretomotor changes. A concentric electromyography needle placed in the right cavernous body was used to record corpus cavernosum electromyography and evoked cavernous activity. The right median nerve was stimulated electrically with 13 to 16 mA. to determine evoked cavernous activity and the penile sympathetic skin response. The latter response was recorded with silver disc electrodes placed on the left cavernous body. All tests were performed using an electromyography/evoked potential machine. We determined the relationships among corpus cavernosum electromyography, evoked cavernous activity and penile sympathetic skin response tests in respect to etiological factors. The 56 patients with normal corpus cavernosum electromyography activity had also evoked cavernous activity and a penile sympathetic skin response except for 1 with no penile sympathetic skin response but evoked cavernous activity. None of these patients had autonomic neuropathy. Of the 19 patients without corpus cavernosum electromyography activity 11 had

  14. Experimental characterization of resistive joints for use inside ATLAS toroids

    CERN Document Server

    Volpini, G; Pojer, M

    2001-01-01

    The authors have investigated, both experimentally and theoretically, the thermo-electrical behavior of the ATLAS magnets resistive joints. These magnets exploit an Al-clad NbTi Rutherford superconducting cable, and the splices between different sections are performed by TIG-welding the Al matrices of the two cables to be connected. This technique is simple from a construction point of view, and we have shown that its performance is adequate for a safe operation of the magnets. The two main concerns during the design of these joints are the temperature rise due to Joule dissipation and the eddy currents induced under nonstationary conditions. We have devised a reliable model of these joints, that allows estimating their resistances and the induced eddy currents; later we have built and measured several sample joints to give experimental confirmation. The model requires, along with the joint geometry, the knowledge of the Rutherford-matrix interface resistance as well as the RRR of the aluminum matrix. In this...

  15. [Apoptosis in rat corpus cavernous penis after neruotomy of bilateral dorsal nerve of penis and/or cavernous nerve].

    Science.gov (United States)

    Ruan, Yi-Sheng; Zhu, Guang-You

    2008-04-01

    To observe the apoptosis in penile corpus cavernous after neurotomy. After neurotomy, 78 SD rats were randomly assigned to experimental and normal control groups at day 1, 2, 4, 8, 16, and 32 time point. The quality was measured by DNA Ladder and the quantitation was measured by TUNEL. The location of apoptosis was detected by dual stained with immunohistochemistry and TUNEL. After transaction of cavernous nerve, dorsal never, and both nerves, the apoptosis in experimental and control group showed a statistically significant difference (P0.0046). There was a statistically significant difference in apoptosis between cavernous smooth muscle cell and endothelial cell groups (PCavernous nerve transection induces apoptosis in smooth muscle cells of the rat penis, but nor does dorsal nerve transaction alone. There is no statistically significant difference in apoptosis between cavernous nerve injury alone and combination injuries of cavernous nerve and dorsal nerve.

  16. Cerebral Cavernous Malformation

    Science.gov (United States)

    ... Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels Synapses Circuits Cluster Scientific Director, Division of Intramural Research Featured Director's Message menu search Enter Search Term Submit Search Cerebral Cavernous Malformation ...

  17. Cavernous Angioma and Children

    Science.gov (United States)

    ... an adult would. Although not a reason to panic, a trip to the pediatrician would be a ... Symptoms and Treatment Brainstem Cavernous Angiomas Central Pain Syndrome Epilepsy Hemorrhage Radiosurgery Venous Angioma/DVA Surgery Preparing ...

  18. CMS cavern inspection robot

    CERN Document Server

    Ibrahim, Ibrahim

    2017-01-01

    Robots which are immune to the CMS cavern environment, wirelessly controlled: -One actuated by smart materials (Ionic Polymer-Metal Composites and Macro Fiber Composites) -One regular brushed DC rover -One servo-driven rover -Stair-climbing robot

  19. Brainstem Cavernous Angioma

    Science.gov (United States)

    ... in obliteration of the angioma. [9] At a minimum, radiosurgery treatment for brainstem cavernous angioma is controversial. Given the advancement in minimally invasive surgical techniques, more and more neurosurgeons are becoming ...

  20. Thermal analysis of the airflow around ATLAS muon end cap

    CERN Document Server

    Gasser, D

    2003-01-01

    A thermal analysis of the airflow inside the UX15 cavern and through the ATLAS detector is presented. This study is done using a CFD (Computational Fluid Dynamics) model. This model includes a simplified geometry of the detector and the experimental cavern, the ventilation flow rate and the released heat dissipation figures are taken into account. This analysis aims at estimate the temperature gradients that develop in the muons end cap area. Indeed, light rays seen by CCD camera will be used in this area in order to align the muon chambers. The rays should not be too much distorted by temperature difference, which would hinder the chamber alignment. The simulation results show that a light ray projected through the whole end cap area should not encounter a gradient higher than 5 K. Nevertheless, the results of this analysis are valid if and only if the spaces represented as empty in the model are allowed to remain empty in ATLAS.

  1. ATLAS Visitors Centre

    CERN Multimedia

    claudia Marcelloni

    2009-01-01

    ATLAS Visitors Centre has opened its shiny new doors to the public. Officially launched on Monday February 23rd, 2009, the permanent exhibition at Point 1 was conceived as a tour resource for ATLAS guides, and as a way to preserve the public’s opportunity to get a close-up look at the experiment in action when the cavern is sealed.

  2. ATLAS starts moving in

    CERN Multimedia

    Della Mussia, S

    2004-01-01

    The first large active detector component was lowered into the ATLAS cavern on 1st March. It consisted of the 8 modules forming the lower part of the central barrel of the tile hadronic calorimeter. The work of assembling the barrel, which comprises 64 modules, started the following day. Two road trailers each with 64 wheels, positioned side by side. This was the solution chosen to transport the lower part of the central barrel of ATLAS' tile hadronic calorimeter from Building 185 to the PX16 shaft at Point 1 (see Figure 1). The transportation, and then the installation of the component in the experimental cavern, which took place over three days were, to say the least, rather spectacular. On 25 February, the component, consisting of eight 6-metre modules, was loaded on to the trailers. The segment of the barrel was transported on a steel support so that it wouldn't move an inch during the journey. On 26 February, once all the necessary safety checks had been carried out, the convoy was able to leave Buildi...

  3. Civil engineering status report for the ATLAS & CMS worksites

    CERN Document Server

    Rammer, H; CERN. Geneva. ST Division

    2003-01-01

    Construction work on the civil engineering contracts at Point 1 and Point 5 started in 1998. The new surface buildings and underground structures are necessary to accommodate the ATLAS and CMS detectors for the LHC Project. The principal underground works at both points consist of two new shafts, two caverns along with a number of small connection tunnels and galleries. At Point 1, the works are 90% complete. Most of the surface buildings as well as the shafts and one of the two new caverns have been completed, and the construction of the second cavern is well underway. At Point 5, the works are 70% complete. Most of the surface buildings as well as the shafts and the pillar have been completed. With excavation of the two large caverns complete, the concreting of the final linings has started. The aim of this paper is to present the status of the civil engineering on these worksites and in particular the challenges encountered constructing the experimental caverns.

  4. Gas intrusion into SPR caverns

    Energy Technology Data Exchange (ETDEWEB)

    Hinkebein, T.E.; Bauer, S.J.; Ehgartner, B.L.; Linn, J.K.; Neal, J.T.; Todd, J.L.; Kuhlman, P.S.; Gniady, C.T. [Sandia National Labs., Albuquerque, NM (United States). Underground Storage Technology Dept.; Giles, H.N. [Dept. of Energy, Washington, DC (United States). Strategic Petroleum Reserve

    1995-12-01

    The conditions and occurrence of gas in crude oil stored in Strategic Petroleum Reserve, SPR, caverns is characterized in this report. Many caverns in the SPR show that gas has intruded into the oil from the surrounding salt dome. Historical evidence and the analyses presented here suggest that gas will continue to intrude into many SPR caverns in the future. In considering why only some caverns contain gas, it is concluded that the naturally occurring spatial variability in salt permeability can explain the range of gas content measured in SPR caverns. Further, it is not possible to make a one-to-one correlation between specific geologic phenomena and the occurrence of gas in salt caverns. However, gas is concluded to be petrogenic in origin. Consequently, attempts have been made to associate the occurrence of gas with salt inhomogeneities including anomalies and other structural features. Two scenarios for actual gas intrusion into caverns were investigated for consistency with existing information. These scenarios are gas release during leaching and gas permeation through salt. Of these mechanisms, the greater consistency comes from the belief that gas permeates to caverns through the salt. A review of historical operating data for five Bryan Mound caverns loosely supports the hypothesis that higher operating pressures reduce gas intrusion into caverns. This conclusion supports a permeability intrusion mechanism. Further, it provides justification for operating the caverns near maximum operating pressure to minimize gas intrusion. Historical gas intrusion rates and estimates of future gas intrusion are given for all caverns.

  5. ATLAS Civil Engineering Point 1

    CERN Multimedia

    Jean-Claude Vialis

    1999-01-01

    ATLAS Civil Engineering - Point 1 In the film you can see various stages of construction in Point 1: that is the experiment zone for ATLAS experimentation. One part of the video is filmed on the surface of Point 1. Therefore you can get the view of the hall SX 1 and the cranes. Cranes are located close to the ridge of the hall roof. The film gives you the view of the hall that covers the caps and the wells to underground cavern where the experiment will be implemented. The machinery for excavation lifts and cranes as well as the stock areas can also be seen. There are iron mounting and concrete works too

  6. Supporting ATLAS

    CERN Multimedia

    2003-01-01

    Eighteen feet made of stainless steel will support the barrel ATLAS detector in the cavern at Point 1. In total, the ATLAS feet system will carry approximately 6000 tons, and will give the same inclination to the detector as the LHC accelerator. The installation of the feet is scheduled to finish during January 2004 with an installation precision at the 1 mm level despite their height of 5.3 metres. The manufacture was carried out in Russia (Company Izhorskiye Zavody in St. Petersburg), as part of a Russian and JINR Dubna in-kind contribution to ATLAS. Involved in the installation is a team from IHEP-Protvino (Russia), the ATLAS technical co-ordination team at CERN, and the CERN survey team. In all, about 15 people are involved. After the feet are in place, the barrel toroid magnet and the barrel calorimeters will be installed. This will keep the ATLAS team busy for the entire year 2004.

  7. Last piece of the puzzle for ATLAS

    CERN Multimedia

    Clare Ryan

    At around 15.40 on Friday 29th February the ATLAS collaboration cracked open the champagne as the second of the small wheels was lowered into the cavern. Each of ATLAS' small wheels are 9.3 metres in diameter and weigh 100 tonnes including the massive shielding elements. They are the final parts of ATLAS' muon spectrometer. The first piece of ATLAS was installed in 2003 and since then many detector elements have journeyed down the 100 metre shaft into the ATLAS underground cavern. This last piece completes this gigantic puzzle.

  8. 16 February 2012 - Chinese Taipei Ambassador to Switzerland F. Hsieh in the ATLAS visitor centre, ATLAS experimental area and LHC tunnel at Point 1 with Collaboration Deputy Sookesperson A. Lankford, throughout accompanied by International Relations Adviser R. Voss.

    CERN Document Server

    Jean-Claude Gadmer

    2012-01-01

    16 February 2012 - Chinese Taipei Ambassador to Switzerland F. Hsieh in the ATLAS visitor centre, ATLAS experimental area and LHC tunnel at Point 1 with Collaboration Deputy Sookesperson A. Lankford, throughout accompanied by International Relations Adviser R. Voss.

  9. Pediatric cavernous sinus thrombosis

    Science.gov (United States)

    Vossough, Arastoo; Vorona, Gregory A.; Beslow, Lauren A.; Ichord, Rebecca N.; Licht, Daniel J.

    2015-01-01

    Objective: To describe clinical characteristics, imaging findings, morbidity, and mortality in a single-center cohort of 12 pediatric cavernous sinus thrombosis cases and to review all cases available in recent English literature. Methods: Clinical data and radiographic studies on 12 cases from our institution were analyzed retrospectively. A literature search and review was conducted, with additional cases pooled with the new cohort for an aggregate analysis. Results: Twelve cases of cavernous sinus thrombosis in children from the Children's Hospital of Philadelphia between January 1, 2000, and December 31, 2013, were reviewed. All patients survived to discharge; 3 of 12 (25%) experienced neurologic morbidity. Contrast-enhanced MRI and contrast-enhanced head CT were 100% sensitive for detecting cavernous sinus thrombosis, while noncontrast time-of-flight magnetic resonance venography (TOF MRV) and noncontrast head CT were 0% sensitive. Literature review produced an additional 40 cases, and the aggregate mortality rate was 4 of 52 (8%) and morbidity rate was 10 of 40 (25%). Outcomes did not vary by treatment or with unilateral vs bilateral cavernous sinus involvement. There was a trend toward worse outcomes with fungal infections. Conclusion: Our case series demonstrates low morbidity and mortality with early, aggressive surgical, antimicrobial, and anticoagulation therapies. Although anticoagulation and surgery were not associated with significantly different outcomes, more study is needed. PMID:26231260

  10. Genetics Home Reference: cerebral cavernous malformation

    Science.gov (United States)

    ... Twitter Home Health Conditions Cerebral cavernous malformation Cerebral cavernous malformation Printable PDF Open All Close All Enable ... to view the expand/collapse boxes. Description Cerebral cavernous malformations are collections of small blood vessels ( capillaries ) ...

  11. Make way for the ATLAS magnet

    CERN Multimedia

    2007-01-01

    On 5 and 6 February, the first ATLAS End Cap Toroid magnet was transported to begin a two-month regime of cryogenic testing. The magnet is scheduled to be installed in the cavern the first week of June.

  12. Lowering the first ATLAS toroid

    CERN Multimedia

    Maximilien Brice

    2004-01-01

    The ATLAS detector on the LHC at CERN will consist of eight toroid magnets, the first of which was lowered into the cavern in these images on 26 October 2004. The coils are supported on platforms where they will be attached to form a giant torus. The platforms will hold about 300 tonnes of ATLAS' muon chambers and will envelop the inner detectors.

  13. Cerebral Cavernous Malformation and Hemorrhage

    Science.gov (United States)

    ... or neurosurgeon that is familiar with your neurological history and who is knowledgeable about cavernous malformations and about epilepsy in pregnancy. Preventative Measures and Other Considerations So ...

  14. 9th May 2008 - Members of Saudi government visiting ATLAS control room and cavern with Technical Coordinator M. Nessi and Adviser to the Director-General D. Blechschmidt.

    CERN Multimedia

    Mona Schweizer

    2008-01-01

    CERN-HI-0804043 05: from left to right 1st row Mrs. Ibtesam Badhrees, ATLAS Collaboration user Mr. Nadhmi Al-Nassr, Interim President, King Abdullah University of Science and Technology, KAUST H.E. Dr. Khaled S. Al-Sultan, Rector, King Fahd University for Petroleum and Minerals Mr. Abdallah S. Jum’ah, President and Chief Executive Officer, Saudi Aramco H.E. Dr. Ibrahim A. Al-Assaf, Minister of Finance H.E. Dr. Abdul Rahman Al-Tuwaijri, Chairman of Capital Markets Authority H.E. Dr. Mohammed I. Al-Suwaiyel, President, King Abdul Aziz City for Science & Technology KACST; 2nd row Mr. Salim S. Al-Aydh, Senior Vice President – Engineering & Project Management, Saudi Aramco Mr. Khalid A. Al-Falih, Executive Vice President – Operations, Saudi Aramco Mr. A. Othman, Saudi Aramco Mr. Peter Woicke, Member of the Saudi Aramco Board of Directors Mr. Abdulaziz F. Al-Khayyal, Senior Vice President – Industrial Relations, Saudi Aramco Mr. James W. Kinnear, Retired President & Chief Executive Office...

  15. 22. August 2013 - Permanent Representative of the Republic of Korea to the United Nations Office and other international organizations in Geneva, Ambassador Extraordinary and Plenipotentiary S. Choi signing the guest book with Director-General R. Heuer; visiting the LHC tunnel with P. Fessia and the CMS experimental cavern with Former Collaboration Spokesperson J. Virdee.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    22. August 2013 - Permanent Representative of the Republic of Korea to the United Nations Office and other international organizations in Geneva, Ambassador Extraordinary and Plenipotentiary S. Choi signing the guest book with Director-General R. Heuer; visiting the LHC tunnel with P. Fessia and the CMS experimental cavern with Former Collaboration Spokesperson J. Virdee.

  16. 25 April 2012 - Latvia Riga Technical University Rector L. Ribickis signing the guest book with CERN Director-General R. Heuer and visiting the LHC tunnel at Point 5 and CMS experimental cavern with Deputy Spokesperson T. Camporesi and Adviser for the Republic of Latvia T. Kurtyka.

    CERN Multimedia

    Maximilien Brice

    2012-01-01

    25 April 2012 - Latvia Riga Technical University Rector L. Ribickis signing the guest book with CERN Director-General R. Heuer and visiting the LHC tunnel at Point 5 and CMS experimental cavern with Deputy Spokesperson T. Camporesi and Adviser for the Republic of Latvia T. Kurtyka.

  17. 24 May 2013 - Rector of the Polish Stanislaw Staszic AGH University of Science and Technology T. Slomka in the LHC tunnel at Point 8 with Senior Polish Staff Member A. Siemko, in LHCb experimental cavern with LHCb Collaboration Spokesperson P. Campana and signing the guest book with Director-General R. Heuer. Adviser for Eastern Europe T. Kurtyka present.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    24 May 2013 - Rector of the Polish Stanislaw Staszic AGH University of Science and Technology T. Slomka in the LHC tunnel at Point 8 with Senior Polish Staff Member A. Siemko, in LHCb experimental cavern with LHCb Collaboration Spokesperson P. Campana and signing the guest book with Director-General R. Heuer. Adviser for Eastern Europe T. Kurtyka present.

  18. 16 Augur 2013 -Bulgarian Minister of Education and Sciences A. Klisarova visiting the LHC tunnel with S. Russenschuck and CMS experimental cavern with Deputy Spokesperson T. Camporesi and V. Genchev ; signing the guest book with CERN Director-General R. Heuer. Accompanied throughout by P. Hristov, L. Litov, R. Voss and Z. Zaharieva.

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    16 Augur 2013 -Bulgarian Minister of Education and Sciences A. Klisarova visiting the LHC tunnel with S. Russenschuck and CMS experimental cavern with Deputy Spokesperson T. Camporesi and V. Genchev ; signing the guest book with CERN Director-General R. Heuer. Accompanied throughout by P. Hristov, L. Litov, R. Voss and Z. Zaharieva.

  19. 22 May 2013 - Turkish Minister of Health M. Müezzinoğlu signing the guest book with Director-General R. Heuer; in the LHC tunnel at Point 5 with International Relations Adviser E. Tsesmelis; in CMS experimental cavern with Deputy Spokesperson T. Camporesi. Turkish Scientists S. A. Cetin and B. Demirkoz present.

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    22 May 2013 - Turkish Minister of Health M. Müezzinoğlu signing the guest book with Director-General R. Heuer; in the LHC tunnel at Point 5 with International Relations Adviser E. Tsesmelis; in CMS experimental cavern with Deputy Spokesperson T. Camporesi. Turkish Scientists S. A. Cetin and B. Demirkoz present.

  20. 18 February 2013 - Foundation for Polish Science President M. Zylicz signing the guest book with CERN Director for Research and Scientific Computing S. Bertolucci; visiting the ALICE experimental cavern with K. Safarik and L. Graczykowskind LHC tunnel with Technology Department A. Siemko.

    CERN Multimedia

    Samuel Morier-Genoud

    2013-01-01

    18 February 2013 - Foundation for Polish Science President M. Zylicz signing the guest book with CERN Director for Research and Scientific Computing S. Bertolucci; visiting the ALICE experimental cavern with K. Safarik and L. Graczykowskind LHC tunnel with Technology Department A. Siemko.

  1. 21 May 2013 - Slovakian State Secretary, Ministry of Health V. Čislák signing the Guest Book with CERN Director-General R. Heuer; in the LHC tunnel at Point 2 with V. Senaj (Technology Department); in the ALICE experimental cavern with P. Chochula (Physics Department). M. Cirilli (Knowledge Transfer Group) present.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    21 May 2013 - Slovakian State Secretary, Ministry of Health V. Čislák signing the Guest Book with CERN Director-General R. Heuer; in the LHC tunnel at Point 2 with V. Senaj (Technology Department); in the ALICE experimental cavern with P. Chochula (Physics Department). M. Cirilli (Knowledge Transfer Group) present.

  2. Conservative management of cavernous sinus cavernous hemangioma in pregnancy.

    Science.gov (United States)

    Haber, Jessica S; Kesavabhotla, Kartik; Ottenhausen, Malte; Bodhinayake, Imithri; Dinkin, Marc J; Segal, Alan Z; Lee, Young M; Boockvar, John A

    2014-06-01

    Cavernous sinus cavernous hemangiomas in pregnancy are extremely rare lesions. The precise management of these lesions remains unknown. The authors present a case of a cavernous hemangioma in pregnancy, centered within the cavernous sinus that underwent postpartum involution without surgical intervention. A 34-year-old pregnant patient (gravida 1, para 0) presented to an otolaryngologist with persistent headache and left-sided facial pain and numbness in the V1 distribution. While being treated for sinusitis, her symptoms progressed to include a left-sided oculomotor palsy and abducens palsy. Magnetic resonance imaging without contrast revealed an expansile mass within the left cavernous sinus consistent with a cavernous hemangioma. The patient was evaluated by a neurosurgeon who recommended close follow-up and postpartum imaging without surgical intervention. Although the lesion enlarged during pregnancy, the patient was able to undergo an uncomplicated cesarean section at 37 weeks. All facial and ocular symptoms resolved by 9 months postpartum, and MRI showed a decrease in lesion size and reduced mass effect. The authors conclude that nonsurgical management may be a viable approach in patients who have an onset or exacerbation of symptoms associated with cavernous sinus cavernous hemangiomas during pregnancy because postpartum involution may negate the need for surgical intervention.

  3. Atlas of experimentally-induced neoplasia in beagle dogs

    Energy Technology Data Exchange (ETDEWEB)

    Dagle, G.E.; Watson, C.R.

    1996-10-01

    Beagle dogs have been utilized extensively in biomedical research. The US Department of Energy`s (DOE) Office of Health and Environmental Research (OHER) has sponsored life-span dose-effect radiation studies in beagles at various laboratories. Because results from studies in the various laboratories were to be compared, all the investigators strove to use similar nomenclature and criteria to describe biological effects. For this reason, pathologists from these laboratories met on five occasions between 1976 and 1977 to discuss nomenclature and histologic criteria for diagnoses. At these meeting, criteria were discussed for histopathologic description of lesions in bone, liver, lung, hematopoietic and lymphoid tissues, mammary gland, pituitary, testis, and thyroid. To provide further assurance of cooperation among the DOE laboratories involved, DOE organized several Task Groups in 1985, composed of staff members from the laboratories. The Task Group on Biological Effects was asked to standardize nomenclature and diagnostic criteria for pathology; this beagle pathology atlas is the result of that request. The atlas describes target organs of particular interest: lungs for radionuclides delivered by inhalation; bones for bone-seeking radionuclides; and hematopoietic and other soft tissues for external irradiation.

  4. ATLAS

    Data.gov (United States)

    Federal Laboratory Consortium — ATLAS is a particle physics experiment at the Large Hadron Collider at CERN, the European Organization for Nuclear Research. Scientists from Brookhaven have played...

  5. Spring comes for ATLAS

    CERN Multimedia

    Butin, F.

    2004-01-01

    (First published in the CERN weekly bulletin 24/2004, 7 June 2004.) A short while ago the ATLAS cavern underwent a spring clean, marking the end of the installation of the detector's support structures and the cavern's general infrastructure. The list of infrastructure to be installed in the ATLAS cavern from September 2003 was long: a thousand tonnes of mechanical structures spread over 13 storeys, two lifts, two 65-tonne overhead travelling cranes 25 metres above cavern floor, with a telescopic boom and cradle to access the remaining 10 metres of the cavern, a ventilation system for the 55 000 cubic metre cavern, a drainage system, a standard sprinkler system and an innovative foam fire-extinguishing system, as well as the external cryogenic system for the superconducting magnets and the liquid argon calorimeters (comprising, amongst other things, two helium refrigeration units, a nitrogen refrigeration unit and 5 km of piping for gaseous or liquid helium and nitrogen), not to mention the handling eq...

  6. The Latest from ATLAS

    CERN Multimedia

    2009-01-01

    Since November 2008, ATLAS has undertaken detailed maintenance, consolidation and repair work on the detector (see Bulletin of 20 July 2009). Today, the fraction of the detector that is operational has increased compared to last year: less than 1% of dead channels for most of the sub-systems. "We are going to start taking data this year with a detector which is even more efficient than it was last year," agrees ATLAS Spokesperson, Fabiola Gianotti. By mid-September the detector was fully closed again, and the cavern sealed. The magnet system has been operated at nominal current for extensive periods over recent months. Once the cavern was sealed, ATLAS began two weeks of combined running. Right now, subsystems are joining the run incrementally until the point where the whole detector is integrated and running as one. In the words of ATLAS Technical Coordinator, Marzio Nessi: "Now we really start physics." In parallel, the analysis ...

  7. Brainstem and cerebellar cavernous malformations.

    Science.gov (United States)

    Atwal, Gursant S; Sarris, Christina E; Spetzler, Robert F

    2017-01-01

    Cavernous malformations are vascular lesions that occur throughout the central nervous system, most commonly in the supratentorial location, with brainstem and cerebellar cavernous malformations occurring more rarely. Cavernous malformations are associated with developmental venous anomalies that occur sporadically or in familial form. Patients with a cavernous malformation can present with headaches, seizures, sensorimotor disturbances, or focal neurologic deficits based on the anatomic location of the lesion. Patients with infratentorial lesions present more commonly with a focal neurologic deficit. Cavernous malformations are increasingly discovered incidentally due to the increasing use of magnetic resonance imaging. Understanding the natural history of these lesions is essential to their management. Observation and surgical resection are both reasonable options in the treatment of patients with these lesions. The clinical presentation of the patient, the location of the lesion, and the surgical risk assessment all play critical roles in management decision-making. © 2017 Elsevier B.V. All rights reserved.

  8. Novel Technique for the UX15 Cavern Vault Support System

    CERN Document Server

    Rammer, H

    2000-01-01

    The overall LHC project schedule requires the civil engineering work to begin before the final LEP shutdown. The new caverns for the ATLAS experiment will be built in and around the existing underground structures at point 1. In order to make the best possible use of the time available for the LHC civil engineering before the shutdown of LEP, a particular arrangement for the construction of the UX15 cavern vault has been developed. The basic concept of this arrangement consists of the excavation of the cavern top heading and the installation of the concrete vault immediately afterwards, prior to the subsequent bench excavation after LEP shutdown. A temporary support of the dead weight of the concrete roof will be achieved by the suspension of the roof by 38 no. pre-stressed ground anchors of 225 tons capacity each. This support system will work up to the construction of the cavern base slab and walls and the completion of the permanent concrete lining.

  9. Lino Baranao, President of the National Agency for the Promotion of Science and Technology in Argentina, toured the ATLAS experiment's underground cavern during his visit to CERN on 9 May

    CERN Multimedia

    Patrice Loïez

    2005-01-01

    Picture 01 : Here he is seen with ATLAS spokesperson, Peter Jenni (left), and the ATLAS Muon System project leader, Giora Mikenberg, listening to Karina Loureiro (right), an Argentinian student at the University of Wisconsin

  10. ATLAS starts moving in

    CERN Multimedia

    2004-01-01

    The first large active detector component was lowered into the ATLAS cavern on 1 March. It consisted of the 8 modules forming the lower part of the central barrel of the tile hadronic calorimeter. The work of assembling the barrel, which comprises 64 modules, started the following day.

  11. ATLAS

    CERN Multimedia

    2002-01-01

    Barrel and END-CAP Toroids In order to produce a powerful magnetic field to bend the paths of the muons, the ATLAS detector uses an exceptionally large system of air-core toroids arranged outside the calorimeter volumes. The large volume magnetic field has a wide angular coverage and strengths of up to 4.7tesla. The toroids system contains over 100km of superconducting wire and has a design current of 20 500 amperes. (ATLAS brochure: The Technical Challenges)

  12. Cavernous lymphangioma: Two case reports

    Directory of Open Access Journals (Sweden)

    Cynthia Sargunam

    2013-01-01

    Full Text Available Lymphangiomas are congenital malformation of the lymphatic system that involve the skin and subcutaneous tissues. We are reporting two cases of cavernous lymphangioma. These cases are presented for their rarity.

  13. Cavernous sinus thrombosis: current therapy.

    Science.gov (United States)

    Desa, Valmont; Green, Ryan

    2012-09-01

    Cavernous sinus thrombosis represents a rare but devastating disease process that may be associated with significant long-term patient morbidity or mortality. The prompt recognition and management of this problem is critical. However, most of the literature involves case-specific discussions. The purpose of this article was to review the literature and present current recommendations for the treatment of cavernous sinus thrombosis. Copyright © 2012 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  14. ATLAS: First rehearsal for the tile calorimeter

    CERN Multimedia

    2003-01-01

    The dry run assembly of the first barrel of the ATLAS tile hadron calorimeter has been successfully completed. It is now being dismantled again so that it can be lowered into the ATLAS cavern where it will be reassembled in October 2004.

  15. ATLAS

    CERN Multimedia

    Akhnazarov, V; Canepa, A; Bremer, J; Burckhart, H; Cattai, A; Voss, R; Hervas, L; Kaplon, J; Nessi, M; Werner, P; Ten kate, H; Tyrvainen, H; Vandelli, W; Krasznahorkay, A; Gray, H; Alvarez gonzalez, B; Eifert, T F; Rolando, G; Oide, H; Barak, L; Glatzer, J; Backhaus, M; Schaefer, D M; Maciejewski, J P; Milic, A; Jin, S; Von torne, E; Limbach, C; Medinnis, M J; Gregor, I; Levonian, S; Schmitt, S; Waananen, A; Monnier, E; Muanza, S G; Pralavorio, P; Talby, M; Tiouchichine, E; Tocut, V M; Rybkin, G; Wang, S; Lacour, D; Laforge, B; Ocariz, J H; Bertoli, W; Malaescu, B; Sbarra, C; Yamamoto, A; Sasaki, O; Koriki, T; Hara, K; Da silva gomes, A; Carvalho maneira, J; Marcalo da palma, A; Chekulaev, S; Tikhomirov, V; Snesarev, A; Buzykaev, A; Maslennikov, A; Peleganchuk, S; Sukharev, A; Kaplan, B E; Swiatlowski, M J; Nef, P D; Schnoor, U; Oakham, G F; Ueno, R; Orr, R S; Abouzeid, O; Haug, S; Peng, H; Kus, V; Vitek, M; Temming, K K; Dang, N P; Meier, K; Schultz-coulon, H; Geisler, M P; Sander, H; 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Sadrozinski, H; Lockman, W S; Martinez-mc kinney, G; Goussiou, A; Jones, A; Lie, K; Hasegawa, Y; Olcese, M; Gilewsky, V; Harrison, P F; Janus, M; Spangenberg, M; De, K; Ozturk, N; Pal, A K; Darmora, S; Bullock, D J; Oviawe, O; Derkaoui, J E; Rahal, G; Sircar, A; Frey, A S; Stolte, P; Rosien, N; Zoch, K; Li, L; Schouten, D W; Catinaccio, A; Ciapetti, M; Delruelle, N; Ellis, N; Farthouat, P; Hoecker, A; Klioutchnikova, T; Macina, D; Malyukov, S; Spiwoks, R D; Unal, G P; Vandoni, G; Petersen, B A; Pommes, K; Nairz, A M; Wengler, T; Mladenov, D; Solans sanchez, C A; Lantzsch, K; Schmieden, K; Jakobsen, S; Ritsch, E; Sciuccati, A; Alves dos santos, A M; Ouyang, Q; Zhou, M; Brock, I C; Janssen, J; Katzy, J; Anders, C F; Nilsson, B S; Bazan, A; Di ciaccio, L; Yildizkaya, T; Collot, J; Malek, F; Trocme, B S; Breugnon, P; Godiot, S; Adam bourdarios, C; Coulon, J; Duflot, L; Petroff, P G; Zerwas, D; Lieuvin, M; Calderini, G; Laporte, D; Ocariz, J; Gabrielli, A; Ohska, T K; Kurochkin, Y; Kantserov, V; Vasilyeva, L; Speransky, M; Smirnov, S; Antonov, A; Bulekov, O; Tikhonov, Y; Sargsyan, L; Vardanyan, G; Budick, B; Kocian, M L; Luitz, S; Young, C C; Grenier, P J; Kelsey, M; Black, J E; Kneringer, E; Jussel, P; Horton, A J; Beaudry, J; Chandra, A; Ereditato, A; Topfel, C M; Mathieu, R; Bucci, F; Muenstermann, D; White, R M; He, M; Urban, J; Straka, M; Vrba, V; Schumacher, M; Parzefall, U; Mahboubi, K; Sommer, P O; Koepke, L H; Bethke, S; Moser, H; Wiesmann, M; Walkowiak, W A; Fleck, I J; Martinez-perez, M; Sanchez sanchez, C A; Jorgensen roca, S; Accion garcia, E; Sainz ruiz, C A; Valls ferrer, J A; Amoros vicente, G; Vives torrescasana, R; Ouraou, A; Formica, A; Hassani, S; Watson, M F; Cottin buracchio, G F; Bussey, P J; Saxon, D; Ferrando, J E; Collins-tooth, C L; Hall, D C; Cuhadar donszelmann, T; Dawson, I; Duxfield, R; Argyropoulos, T; Brodet, E; Livneh, R; Shougaev, K; Reinherz, E I; Guttman, N; Beretta, M M; Vilucchi, E; Aloisio, A; Patricelli, S; Caprio, M; Cevenini, F; De vecchi, C; Livan, M; Rimoldi, A; Vercesi, V; Ayad, R; Mastroberardino, A; Ciapetti, G; Luminari, L; Rescigno, M; Santonico, R; Salamon, A; Del papa, C; Kurashige, H; Homma, Y; Tomoto, M; Horii, Y; Sugaya, Y; Hanagaki, K; Bobbink, G; Kluit, P M; Koffeman, E N; Van eijk, B; Lee, H; Eigen, G; Dorholt, O; Strandlie, A; Strzempek, P B; Dita, S; Stoicea, G; Chitan, A; Leven, S S; Moa, T; Brenner, R; Ekelof, T J C; Olshevskiy, A; Roumiantsev, V; Chlachidze, G; Zimine, N; Gusakov, Y; Grigalashvili, N; Mineev, M; Potrap, I; Barashkou, A; Shoukavy, D; Shaykhatdenov, B; Pikelner, A; Gladilin, L; Ammosov, V; Abramov, A; Arik, M; Sahinsoy, M; Uysal, Z; Azizi, K; Hotinli, S C; Zhou, S; Berger, E; Blair, R; Underwood, D G; Einsweiler, K; Garcia-sciveres, M A; Siegrist, J L; Kipnis, I; Dahl, O; Holland, S; Barbaro galtieri, A; Smith, P T; Parua, N; Franklin, M; Mercurio, K M; Tong, B; Pod, E; Cole, S G; Hopkins, W H; Guest, D H; Severini, H; Marsicano, J J; Abbott, B K; Wang, Q; Lissauer, D; Ma, H; Takai, H; Rajagopalan, S; Protopopescu, S D; Snyder, S S; Undrus, A; Popescu, R N; Begel, M A; Blocker, C A; Amelung, C; Mandic, I; Macek, B; Tucker, B H; Citterio, M; Troncon, C; Orestano, D; Taccini, C; Romeo, G L; Dova, M T; Taylor, G N; Gesualdi manhaes, A; Mcpherson, R A; Sobie, R; Taylor, R P; Dolezal, Z; Kodys, P; Slovak, R; Sopko, B; Vacek, V; Sanders, M P; Hertenberger, R; Meineck, C; Becks, K; Kind, P; Sandhoff, M; Cantero garcia, J; De la torre perez, H; Castillo gimenez, V; Ros, E; Hernandez jimenez, Y; Chadelas, R; Santoni, C; Washbrook, A J; O'brien, B J; Wynne, B M; Mehta, A; Vossebeld, J H; Landon, M; Teixeira dias castanheira, M; Cerrito, L; Keates, J R; Fassouliotis, D; Chardalas, M; Manousos, A; Grachev, V; Seliverstov, D; Sedykh, E; Cakir, O; Ciftci, R; Edson, W; Prell, S A; Rosati, M; Stroman, T; Jiang, H; Neal, H A; Li, X; Gan, K K; Smith, D S; Kruse, M C; Ko, B R; Leung fook cheong, A M; Cole, B; Angerami, A R; Greene, Z S; Kroll, J I; Van berg, R P; Forbush, D A; Lubatti, H; Raisher, J; Shupe, M A; Wolin, S; Oshita, H; Gaudio, G; Das, R; Konig, A C; Croft, V A; Harvey, A; Maaroufi, F; Melo, I; Greenwood jr, Z D; Shabalina, E; Mchedlidze, G; Drechsler, E; Rieger, J K; Blackston, M; Colombo, T

    2002-01-01

    % ATLAS \\\\ \\\\ ATLAS is a general-purpose experiment for recording proton-proton collisions at LHC. The ATLAS collaboration consists of 144 participating institutions (June 1998) with more than 1750~physicists and engineers (700 from non-Member States). The detector design has been optimized to cover the largest possible range of LHC physics: searches for Higgs bosons and alternative schemes for the spontaneous symmetry-breaking mechanism; searches for supersymmetric particles, new gauge bosons, leptoquarks, and quark and lepton compositeness indicating extensions to the Standard Model and new physics beyond it; studies of the origin of CP violation via high-precision measurements of CP-violating B-decays; high-precision measurements of the third quark family such as the top-quark mass and decay properties, rare decays of B-hadrons, spectroscopy of rare B-hadrons, and $ B ^0 _{s} $-mixing. \\\\ \\\\The ATLAS dectector, shown in the Figure includes an inner tracking detector inside a 2~T~solenoid providing an axial...

  16. MRI of intramedullary cavernous haemangiomas

    Energy Technology Data Exchange (ETDEWEB)

    Turjman, F. [Service de Radiologie, Hopital Neurologique, 69 Lyon (France); Joly, D. [Service de Neuroradiologie, Centre Hospitalier Universitaire Bicetre, 94 Le Kremlin Bicetre (France); Monnet, O. [Service de Neuroradiologie, Centre Hospitalier Universitaire Bicetre, 94 Le Kremlin Bicetre (France); Faure, C. [Service de Radiologie, Hopital Neurologique, 69 Lyon (France); Doyon, D. [Service de Neuroradiologie, Centre Hospitalier Universitaire Bicetre, 94 Le Kremlin Bicetre (France); Froment, J.C. [Service de Radiologie, Hopital Neurologique, 69 Lyon (France)

    1995-05-01

    We reviewed 11 cases of intramedullary cavernous haemangiomas (IMCH) studied by MRI, to assess its diagnostic value in these lesions. Follow-up MRI was obtained in five patients 7 days-2 years following the initial study. In one case a postoperative examination was obtained. The diagnosis was pathologically proven in ten cases, and supported in the last by a family and personal history of cavernous haemangiomas. A reticulate appearance with areas of mixed signal intensity in both T1- and T2-weighted images was the most common finding. Homogeneous high, low or intermediate signal intensity was each found in one case. Two small lesions gave low signal. A rim of low signal was less common than in cerebral cavernous haemangiomas. In one case, the brain showed more than 20 lesions with the MRI appearances of cavernous haemangiomas. In two of five patients, serial preoperative MRI showed progressive disappearance of high-signal areas on both T1- and T2-weighted images. To find a haemorrhagic intramedullary lesion on MRI is not rare. Although the appearances are not pathognomonic, an IMCH can be suggested. We suggest that the following characteristics may help: (1) a personal and/or family history of cavernous haemangiomas; (2) typical MRI appearances of mixed acute, subacute and chronic haemorrhage; (3) a tendency for signal intensity to decrease on follow-up; (4) normal spinal angiography; and (5) associated brain lesions. (orig.)

  17. ATLAS' major cooling project

    CERN Multimedia

    2005-01-01

    In 2005, a considerable effort has been put into commissioning the various units of ATLAS' complex cryogenic system. This is in preparation for the imminent cooling of some of the largest components of the detector in their final underground configuration. The liquid helium and nitrogen ATLAS refrigerators in USA 15. Cryogenics plays a vital role in operating massive detectors such as ATLAS. In many ways the liquefied argon, nitrogen and helium are the life-blood of the detector. ATLAS could not function without cryogens that will be constantly pumped via proximity systems to the superconducting magnets and subdetectors. In recent weeks compressors at the surface and underground refrigerators, dewars, pumps, linkages and all manner of other components related to the cryogenic system have been tested and commissioned. Fifty metres underground The helium and nitrogen refrigerators, installed inside the service cavern, are an important part of the ATLAS cryogenic system. Two independent helium refrigerators ...

  18. ATLAS Civil Engineering Point 1

    CERN Multimedia

    2000-01-01

    Different phases of realisation to Point 1: zone of the ATLAS experiment 18-10-2000 UX 15 cavern and PX16 15-12-2000 USA 15 - UX 15 concreting the arch 14-02-2001 UX 15 - ancrages, isolation and scaffolding

  19. ATLAS Fact Sheet : To raise awareness of the ATLAS detector and collaboration on the LHC

    CERN Multimedia

    ATLAS Outreach

    2010-01-01

    Facts on the Detector, Calorimeters, Muon System, Inner Detector, Pixel Detector, Semiconductor Tracker, Transition Radiation Tracker,, Surface hall, Cavern, Detector, Magnet system, Solenoid, Toroid, Event rates, Physics processes, Supersymmetric particles, Comparing LHC with Cosmic rays, Heavy ion collisions, Trigger and Data Acquisition TDAQ, Computing, the LHC and the ATLAS collaboration. This fact sheet also contains images of ATLAS and the collaboration as well as a short list of videos on ATLAS available for viewing.

  20. New public information resources on salt caverns.

    Energy Technology Data Exchange (ETDEWEB)

    Tomasko, D.; Veil, J. A.

    1999-08-25

    For the past decade, interest has been growing in using underground salt caverns for disposing of wastes. The Railroad Commission of Texas has permitted a few caverns for disposal of nonhazardous oil field waste (NOW) and one cavern for disposal of naturally occurring radioactive materials (NORM) from oil field activities. Several salt caverns in Canada have also been permitted for disposal of NOW. In addition, oil and gas agencies in Louisiana and New Mexico are developing cavern disposal regulations. The US Department of Energy (DOE) has funded several studies to evaluate the technical feasibility, legality, economic viability, and risk of disposing of NOW and NORM in caverns. The results of these studies have been disseminated to the scientific and regulatory communities. However, as use of caverns for waste disposal increases, more government and industry representatives and members of the public will become aware of this practice and will need adequate information about how disposal caverns operate and the risks they pose. In anticipation of this need, DOE has fi.mded Argonne National Laboratory to develop a salt cavern public outreach program. Key components of this program are an informational brochure designed for nontechnical persons and a website that provides greater detail on cavern operations and allows downloadable access to the reports on the topic funded by DOE. This paper provides an overview of the public outreach program.

  1. New public information resources on salt caverns.

    Energy Technology Data Exchange (ETDEWEB)

    Tomasko, D.; Veil, J. A.

    1999-08-25

    For the past decade, interest has been growing in using underground salt caverns for disposing of wastes. The Railroad Commission of Texas has permitted a few caverns for disposal of nonhazardous oil field waste (NOW) and one cavern for disposal of naturally occurring radioactive materials (NORM) from oil field activities. Several salt caverns in Canada have also been permitted for disposal of NOW. In addition, oil and gas agencies in Louisiana and New Mexico are developing cavern disposal regulations. The US Department of Energy (DOE) has funded several studies to evaluate the technical feasibility, legality, economic viability, and risk of disposing of NOW and NORM in caverns. The results of these studies have been disseminated to the scientific and regulatory communities. However, as use of caverns for waste disposal increases, more government and industry representatives and members of the public will become aware of this practice and will need adequate information about how disposal caverns operate and the risks they pose. In anticipation of this need, DOE has funded Argonne National Laboratory to develop a salt cavern public outreach program. Key components of this program are an informational brochure designed for nontechnical persons and a website that provides greater detail on cavern operations and allows downloadable access to the reports on the topic funded by DOE. This paper provides an overview of the public outreach program.

  2. Installation of the eighth and final coil of the ATLAS barrel toroid magnet

    CERN Multimedia

    Patrice Loiez

    2005-01-01

    In the underground cavern where the ATLAS detector is being constructed, the last of eight 25-m long toroid magnet coils has been put into place, to complete a huge magnetic barrel that forms a major part of the detector.

  3. ATLAS- lowering the muon small wheel

    CERN Multimedia

    CERN Audiovisual Service

    2008-01-01

    ATLAS - the two muon small wheels lowered into the cavern Like briefly separated twin sisters, ATLAS’s small wheels were once again united at the experiment’s surface building at Point 1 on St Valentine’s Day. The lowering of the small wheels into the tunnel will mark the end of the installation of detector components for the experiment. At around 15.40 on Friday 29th February the ATLAS collaboration cracked open the champagne as the second of the small wheels was lowered into the cavern.

  4. A case of cauda equina cavernous angioma coexisting with multiple cerebral cavernous angiomas.

    Science.gov (United States)

    Takeshima, Yasuhiro; Marutani, Akiko; Tamura, Kentaro; Park, Young-Su; Nakase, Hiroyuki

    2014-08-01

    The simultaneous presence of cavernous angiomas in both the brain and spinal cord is a very rare finding, as is the location of a cavernous angioma in the cauda equina. We reported a unique case of coexisting with multiple cerebral cavernous angiomas in the brain and cauda equina.

  5. ATLAS TV PROJECT

    CERN Multimedia

    OMNI communication

    2005-01-01

    CAMERA ON TOROID The ATLAS barrel toroid system consists of eight coils, each of axial length 25.3 m, assembled radially and symmetrically around the beam axis. The coils are of a flat racetrack type with two double-pancake windings made of 20.5 kA aluminium-stabilized niobium-titanium superconductor. The video is about the slow lowering of the toroid down to the cavern of ATLAS. It is very demanding task. The camera is placed on top of the toroid.

  6. Teratoma of the cavernous sinus: case report.

    Science.gov (United States)

    Pikus, H J; Holmes, B; Harbaugh, R E

    1995-05-01

    We report the case of an infant with a mature teratoma of the lateral wall of the cavernous sinus. A complete excision of the tumor was achieved. There was no evidence of recurrence at 1-year follow-up examination. Intracranial teratomas and the anatomy of the lateral wall of the cavernous sinus are briefly reviewed. To our knowledge, this is the first case of a teratoma confined to the cavernous sinus.

  7. MR findings of septic cavernous sinus thrombosis

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hyeong Lae; Lee, Nam Joon; Lee, Jung Hee; Pyo, Hyeon Soon; Eo, Geun; Kim, Kyo Nam; Kim, Young Soon; Kim, Jang Min [Kwang Myung Sung Ae Hospital, Kwang Myung (Korea, Republic of); Lee, Don Young [Korea University Anam Hospital, Seoul (Korea, Republic of)

    2000-08-01

    To evaluate the MR findings of septic thrombosis of the cavernous sinus. Eleven MR images of six patients with septic cavernous sinus thrombosis obtained over a five-year period and proven clinically or radiologically were retrospectively reviewed. The contour and enhancement pattern of the cavernous sinus, changes in the internal carotid artery, orbit, pituitary gland and sphenoid sinus, and intracranial abnormalities were analyzed and compared with the findings of follow-up studies. In all six patients, contrast study revealed asymmetrical enlargement of the ipsilateral cavernous sinus and multiple irregular filling defects within it. Narrowing of the cavernous portion of the ipsilateral internal carotid artery was noted in five patients, upward displacement of the ipsilateral internal carotid artery in four, ipsilateral proptosis with engorgement of the superior ophthalmic vein in two, pituitary enlargement in five, and inflammatory change in the sphenoid sinus in six. Associated intracranial abnormalities included edema and enhancement in the meninx, temporal lobe, or pons adjacent to the cavernous sinus in four patients, hydrocephalus in one, and cerebral infarction in one. Follow-up MR imaging indicated that the extent of asymmetrical enlargement of the cavernous sinus, filling defects within it, as seen on contrast study, and enlarged pituitary glands had all decreased, without significant interval change. MR imaging is useful in the diagnosis of septic cavernous sinus thrombosis. Asymmetrical enlargement of the cavernous sinus, multiple irregular filling defect within it, as seen on contrast study, and changes in the internal carotid artery are characteristic findings. (author)

  8. The natural history of intracranial cavernous malformations

    National Research Council Canada - National Science Library

    Gross, Bradley A; Lin, Ning; Du, Rose; Day, Arthur L

    2011-01-01

    Literature reports on the natural history of cerebral cavernous malformations (CMs) are numerous, with considerable variability in lesion epidemiology, hemorrhage rates, and risk factors for hemorrhage...

  9. Installation and Commissioning of the ATLAS Liquid Argon Calorimeter Read-Out Electronics

    OpenAIRE

    Perrot, G

    2008-01-01

    The cryostats of the ATLAS LAr calorimeter system are installed in the ATLAS cavern since several years. Following this, an effort to install and commission the front-end and back-end read-out electronics as well as the timing, trigger and control electronics (infrastructure, crates, and boards) has been ongoing and is finished now, in time for the cavern closure. Following cautious procedures and with continuous testing-campaigns of the electronics at each step of the installation advancemen...

  10. EVOKED CAVERNOUS ACTIVITY: NEUROANATOMIC IMPLICATIONS

    OpenAIRE

    Yilmaz, Ugur; Vicars, Brenda; Yang, Claire C.

    2009-01-01

    We investigated the autonomic innervation of the penis by using evoked cavernous activity (ECA). We recruited 7 males with thoracic spinal cord injury (SCI) and sexual dysfunction and 6 males who were scheduled to have pelvic surgery (PS), specifically non-nerve-sparing radical cystoprostatectomy. In the PS subjects, ECA was performed both pre- and postoperatively. The left median nerve was electrically stimulated and ECA was recorded with two concentric electromyography needles placed into t...

  11. Effects of cavern depth on surface subsidence and storage loss of oil-filled caverns

    Energy Technology Data Exchange (ETDEWEB)

    Hoffman, E L

    1992-01-01

    Finite element analyses of oil-filled caverns were performed to investigate the effects of cavern depth on surface subsidence and storage loss, a primary performance criteria of SPR caverns. The finite element model used for this study was axisymmetric, approximating an infinite array of caverns spaced at 750 ft. The stratigraphy and cavern size were held constant while the cavern depth was varied between 1500 ft and 3000 ft in 500 ft increments. Thirty year simulations, the design life of the typical SPR cavern, were performed with boundary conditions modeling the oil pressure head applied to the cavern lining. A depth dependent temperature gradient of 0.012{degrees}F/ft was also applied to the model. The calculations were performed using ABAQUS, a general purpose of finite element analysis code. The user-defined subroutine option in ABAQUS was used to enter an elastic secondary creep model which includes temperature dependence. The calculations demonstrated that surface subsidence and storage loss rates increase with increasing depth. At lower depths the difference between the lithostatic stress and the oil pressure is greater. Thus, the effective stresses are greater, resulting in higher creep rates. Furthermore, at greater depths the cavern temperatures are higher which also produce higher creep rates. Together, these factors result in faster closure of the cavern. At the end of the 30 year simulations, a 1500 ft-deep cavern exhibited 4 percent storage loss and 4 ft of subsidence while a 3000 ft-deep cavern exhibited 33 percent storage loss and 44 ft of subsidence. The calculations also demonstrated that surface subsidence is directly related to the amount of storage loss. Deeper caverns exhibit more subsidence because the caverns exhibit more storage loss. However, for a given amount of storage loss, nearly the same magnitude of surface subsidence was exhibited, independent of cavern depth.

  12. In-vitro effects of PDE5 inhibitor and statin treatment on the contractile responses of experimental MetS rabbit's cavernous smooth muscle

    Directory of Open Access Journals (Sweden)

    Yasin Erden

    2014-03-01

    Full Text Available Objective: Hypercholesterolaemia promotes erectile dysfunction through increased superoxide formation and decreased nitric oxide bioactivity in cavernosal tissue. The role of nitric oxide on erectile function is well known. Statins have lipid lowering properties and can modulate endothelial nitric oxide bioavailability. Sildenafil, enhances smooth muscle relaxation in corpus cavernosum. We invastigated in-vitro effects of sildenafil and rosuvastatin on nonadrenergic, non-cholinergic and nitric oxide mediated cavernosal smooth musle relaxation in metabolic syndrome rabbits, since alterations in this pathway are recognised in diabetic and hypercholesterolemic erectile dysfunction. Methods: Ten male rabbits were fed a standart diet as control group, fourty male rabbits were fed a hypercholesterolemic diet for 12 weeks. Hypercholesterolemic group were divided for without treatment, rosuvastatin treatment, sildenafil teratment, and rosuvastatin + sildenafil treatment (N = 10 per groups. Results: Serum levels of cholesterol and glucose were significantly higher in the experimental group than in the control group (p < 0.05. After theraphy no differences were found among the groups in relaxation responses to sodium nitroprusside. The relaxation responses to carbachol and EFS were significantly reduced in metabolic syndrome group to control group (p < 0.05, but there were no differences between the other groups and control group. There was a significantly lower in-vitro relaxation response in the metabolic syndrome rabbits than in controls and the others (p < 0.05. Conclusion: Both agents improve in-vitro relaxation responses of erectile tissue from metabolic syndrome rabbits to endothelial non-adrenergic, non-cholinergic and nitric oxide. This finding supports to the results of other clinical studies with these drugs.

  13. Spontaneous Bilateral Carotid-Cavernous Fistulas Secondary to Cavernous Sinus Thrombosis.

    Science.gov (United States)

    Al-Mufti, Fawaz; Amuluru, Krishna; El-Ghanem, Mohammad; Changa, Abhinav R; Singh, Inder Paul; Gandhi, Chirag D; Prestigiacomo, Charles J

    2017-04-01

    Bilateral carotid cavernous fistulas are rare entities that can cause debilitating symptoms and can lead to more severe consequences if left untreated. Therefore, the recognition and adequate treatment of these pathologies is very important. We present 2 cases of bilateral carotid cavernous fistulas that arose as a result of cavernous sinus thrombosis. We review the literature and discuss the pathophysiology, symptomatology, management, and treatment of bilateral carotid cavernous fistulas. Within our own cases, treatment of the patients was varied. The patient in case 1 was successfully treated with endovascular therapy after a failed trial of anticoagulation. The patient in case 2 demonstrated resolution of bilateral carotid cavernous fistulas after anticoagulation therapy. Case 2 highlights the fact that certain cases of bilateral carotid cavernous fistulas due to cavernous sinus thrombosis may benefit from extensive anticoagulation therapy. If anticoagulation therapy is unsuccessful, endovascular therapy may prove beneficial in resolving the fistulous shunt. Copyright © 2017 by the Congress of Neurological Surgeons.

  14. Characterization and commissioning of the ATLAS micromegas quadruplet prototype

    CERN Document Server

    AUTHOR|(CDS)2068921

    2016-01-01

    Micromegas (Micro Mesh Gaseous Structure) chambers have been chosen for the New Small Wheel (NSW) project, the upgrade of the forward muon spectrometer of the ATLAS experiment both to provide precision tracking and contribute to the trigger. A quadruplet (1m $\\times$ 0.5m) has been built at the CERN laboratories, it will serve as prototype for the future ATLAS chambers. This detector is realized using resistive-strip technology and decoupling the amplification mesh from the readout structure. The four readout planes host overall 4096 strips with a pitch of 415 $\\mu m$. A complete detector characterization carried out with cosmic rays, X-Ray source and dedicated test beam is discussed. Characterization is done using analog front-end chip (APV25). The efforts that lead to the chamber construction and the preparation for the installation in the ATLAS experimental cavern are presented. Finally, an overview of the readout system developed for this prototype, and integration into the ATLAS Data Acquisition System i...

  15. Characterization and commissioning of the ATLAS micromegas quadruplet prototype

    CERN Document Server

    Bianco, Michele; The ATLAS collaboration; Iengo, Paolo; Lin, Tai-hua; Schott, Matthias; Sekhniaidze, Givi; Sidiropoulou, Ourania; Valderanis, Chrysostomos; Wotschack, Jorg; Zibell, Andre

    2014-01-01

    Micromegas (Micro Mesh Gaseous Detector) chambers have been chosen for the upgrade of the forward muon spectrometer of the ATLAS experiment to provide precision tracking and also to contribute to the trigger. A quadruplet (1m X 0.5m) has been built at the CERN laboratories, it will serve as prototype for the future ATLAS chambers. This detector is realized using resistive-strip technology and decoupling the amplification mesh from the readout structure. The four readout planes host overall 4096 strips with a pitch of 415$\\mu m$. A complete detector characterization carried out with cosmic rays, X-Ray source and dedicated test beam is discussed, characterization is obtained by use of analog front-end chip (APV25). The efforts that lead to the chamber construction and the preparation for the installation in the ATLAS experimental cavern are presented. Finally, an overview of the readout system developed for this prototype, and integration in to the ATLAS Data Acquisition System is provided.

  16. Successfully Managing the Experimental Area of a Large Physics Experiment from Civil Engineering to the First Beams

    CERN Document Server

    Butin, F

    2010-01-01

    The role of "Experimental Area Manager" supported by a well organized, charismatic and motivated team is absolutely essential for managing the huge effort needed for a multi-cultural, multi-disciplinary installation of cathedral-size underground caverns housing a billion dollar physics experiment. Between the years 2002 and 2008, we supervised and coordinated the ATLAS work site at LHC, from the end of the civil engineering to the first circulating beams, culminating with 240 workers on the site, 24 hours a day, 7 days a week, with activities taking place simultaneously on the surface, in the 60 m shafts and in the 100 m underground experimental cavern. We depict the activities preparation scheme (including tasks ranging from the installation of 280 ton cranes to super-delicate silicon detectors), the work-site organization method, the safety management that was a top priority throughout the whole project, and the opencommunication strategy that required maintaining permanent public visits. The accumulation o...

  17. Fiberoptic imaging of cavernous nerves in vivo.

    Science.gov (United States)

    Boyette, Lisa B; Reardon, Michael A; Mirelman, Andrew J; Kirkley, Terry D; Lysiak, Jeffrey J; Tuttle, Jeremy B; Steers, William D

    2007-12-01

    A critical intraoperative variable for the return of tumescence following radical prostatectomy is preservation of the cavernous nerves. We developed a nontoxic technique that would allow high resolution, in vivo real-time imaging specifically of the cavernous nerves. The cavernous nerves were labeled by injecting a fluorescent retrograde nerve tracer into the corpus cavernosum of male rats. Nerves were subsequently imaged in vivo using fiberoptic confocal fluorescent microscopy. Initial screening trials were performed to decide on a nerve tracer capable of axonal labeling, optimize injection concentration and characterize retrograde transport time. Toxicity studies included intracavernous pressure monitoring following electrical nerve stimulation, apoptotic staining of injected cavernous tissue and measurement of lipid peroxidation in nerves exposed to laser emissions during imaging. In vivo real-time video sequences of fluorescently labeled cavernous nerves were recorded. The screening trial indicated that the B subunit of cholera toxin conjugated to AlexaFluor 488 (Invitrogen) provided optimal imaging after 9 days of retrograde transport. Toxicity studies showed that maximal intracavernous pressure responses did not differ between labeled and unlabeled nerves (p = 0.9671). Tracer injection did not increase apoptosis in cavernous tissue and laser exposure did not increase lipid peroxidation in nerves. In vivo real-time imaging of the cavernous nerves is possible with no measurable toxicity, allowing the maintenance of erection. This novel imaging modality may allow urologists to identify cavernous nerves during pelvic surgery.

  18. [A case of posttraumatic forehead cavernous angioma].

    Science.gov (United States)

    Nishijima, Haruo; Nishimura, Shinjitsu; Furuno, Yuichi; Kaimori, Mitsuomi; Nishijima, Michiharu

    2009-09-01

    Cavernous angiomas of the bone are rare tumors. Skull cavernomas are even less frequent. Most cavernous angiomas of the bone are congenital tumors. In a review of the literature, we found only one case report of de novo generation of a skull cavernous angioma. We present a case of a 25-year-old woman who had experienced a head injury, and 7 years later exhibited a skull tumor at the exact region of the injury. We performed tumor resection and cranioplasty. Follow-up examinations revealed no recurrence or neurological defects. Pathological findings showed a cavernous angioma-like lesion with some atypical details. We finally diagnosed the lesion as a de novo cavernous angioma. Our case suggests that fine injury may result in de novo generation of bone cavernomas.

  19. Disposal of NORM waste in salt caverns

    Energy Technology Data Exchange (ETDEWEB)

    Veil, J.A.; Smith, K.P.; Tomasko, D.; Elcock, D.; Blunt, D.; Williams, G.P.

    1998-07-01

    Some types of oil and gas production and processing wastes contain naturally occurring radioactive materials (NORM). If NORM is present at concentrations above regulatory levels in oil field waste, the waste requires special disposal practices. The existing disposal options for wastes containing NORM are limited and costly. This paper evaluates the legality, technical feasibility, economics, and human health risk of disposing of NORM-contaminated oil field wastes in salt caverns. Cavern disposal of NORM waste is technically feasible and poses a very low human health risk. From a legal perspective, there are no fatal flaws that would prevent a state regulatory agency from approving cavern disposal of NORM. On the basis of the costs charged by caverns currently used for disposal of nonhazardous oil field waste (NOW), NORM waste disposal caverns could be cost competitive with existing NORM waste disposal methods when regulatory agencies approve the practice.

  20. A 12-year cavern abandonment test

    Directory of Open Access Journals (Sweden)

    Brouard B.

    2010-06-01

    Full Text Available In 1997-1998, an abandonment test was performed in a 950-m deep, 8000-m3 salt cavern operated by GDF SUEZ at Etrez, France. In this relatively small brine-filled cavern, which had been kept idle for 15 years before the test, thermal equilibrium was reached. A special system was designed to monitor leaks, which proved to be exceedingly small. In these conditions, brine permeation and cavern creep closure are the only factors to play significant roles in pressure evolution. This test strongly suggested that obtaining an equilibrium pressure such that the effects of these two factors were exactly equal would be reached in the long term. Four years later, pressure monitoring in the closed cavern resumed. Pressure evolution during the 2002-2009 period confirmed that cavern brine pressure will remain constant and significantly smaller than geostatic pressure in the long term, precluding any risk of fracturing and brine seepage to the overburden layers.

  1. Noncavernous arteriovenous shunts mimicking carotid cavernous fistulae.

    Science.gov (United States)

    Kobkitsuksakul, Chai; Jiarakongmun, Pakorn; Chanthanaphak, Ekachat; Pongpech, Sirintara

    2016-01-01

    The classic symptoms and signs of carotid cavernous sinus fistula or cavernous sinus dural arteriovenous fistula (AVF) consist of eye redness, exophthalmos, and gaze abnormality. The angiography findings typically consist of arteriovenous shunt at cavernous sinus with ophthalmic venous drainage with or without cortical venous reflux. In rare circumstances, the shunts are localized outside the cavernous sinus, but mimic symptoms and radiography of the cavernous shunt. We would like to present the other locations of the arteriovenous shunt, which mimic the clinical presentation of carotid cavernous fistulae, and analyze venous drainages. We retrospectively examined the records of 350 patients who were given provisional diagnoses of carotid cavernous sinus fistulae or cavernous sinus dural AVF in the division of Interventional Neuroradiology, Ramathibodi Hospital, Bangkok between 2008 and 2014. Any patient with cavernous arteriovenous shunt was excluded. Of those 350 patients, 10 patients (2.85%) were identified as having noncavernous sinus AVF. The angiographic diagnoses consisted of three anterior condylar (hypoglossal) dural AVF, two traumatic middle meningeal AVF, one lesser sphenoid wing dural AVF, one vertebro-vertebral fistula (VVF), one intraorbital AVF, one direct dural artery to cortical vein dural AVF, and one transverse-sigmoid dural AVF. Six cases (60%) were found to have venous efferent obstruction. Arteriovenous shunts mimicking the cavernous AVF are rare, with a prevalence of only 2.85% in this series. The clinical presentation mainly depends on venous outflow. The venous outlet of the arteriovenous shunts is influenced by venous afferent-efferent patterns according to the venous anatomy of the central nervous system and the skull base, as well as by architectural disturbance, specifically, obstruction of the venous outflow.

  2. ATLAS Installation: Building a Modern-day "Ship in a Bottle"

    CERN Multimedia

    Eisenstein, R

    By now, almost everyone connected with the ATLAS project is aware of its tremendously exciting discovery potential for physics. ATLAS is designed both to search for an as-yet-undiscovered piece of the Standard Model - the Higgs boson - as well as to search for indications of possible new physics - such as Supersymmetry - that lie beyond it. It is just this excitement that has propelled more than 2000 physicists, engineers, technical workers and students from all over the world to commit a significant part of their research careers to this massive undertaking. As the sub-detector components of ATLAS continue to arrive regularly here at CERN, the magnitude - and the quality - of that commitment has become very real. Actual objects exist, in building 180 and other places around the CERN site, waiting for installation into the ATLAS cavern, UX15. That installation will begin next April when ATLAS takes delivery of the experimental hall and associated other buildings and underground structures at Point 1. Indeed,...

  3. ATLAS Civil Engineering at Point 1

    CERN Multimedia

    2002-01-01

    Views of ATLAS cavern under the construction, many views also from the Pit where all the parts and machines will be lowered in the future. This film includes views that are taken partly from the tunnel side also. Please note that the video is partly in form of seguence pictures on photo style.

  4. Rock cavern storage of spent fuel

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Won Jin; Kim, Kyung Soo [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Kwon, Sang Ki [Inha University, Incheon (Korea, Republic of)

    2015-12-15

    The rock cavern storage for spent fuel has been assessed to apply in Korea with reviewing the state of the art of the technologies for surface storage and rock cavern storage of spent fuel. The technical feasibility and economic aspects of the rock cavern storage of spent fuel were also analyzed. A considerable area of flat land isolated from the exterior are needed to meet the requirement for the site of the surface storage facilities. It may, however, not be easy to secure such areas in the mountainous region of Korea. Instead, the spent fuel storage facilities constructed in the rock cavern moderate their demands for the suitable site. As a result, the rock cavern storage is a promising alternative for the storage of spent fuel in the aspect of natural and social environments. The rock cavern storage of spent fuel has several advantages compared with the surface storage, and there is no significant difference on the viewpoint of economy between the two alternatives. In addition, no great technical difficulties are present to apply the rock cavern storage technologies to the storage of domestic spent fuel.

  5. Evoked cavernous activity: neuroanatomic implications.

    Science.gov (United States)

    Yilmaz, U; Vicars, B; Yang, C C

    2009-01-01

    We investigated the autonomic innervation of the penis by using evoked cavernous activity (ECA). We recruited seven men with thoracic spinal cord injury (SCI) and sexual dysfunction, and six men who were scheduled to have pelvic surgery (PS), specifically non-nerve-sparing radical cystoprostatectomy. In the PS patients, ECA was performed both pre- and postoperatively. The left median nerve was electrically stimulated and ECA was recorded with two concentric electromyography needles placed into the right and left cavernous bodies. We simultaneously recorded hand and foot sympathetic skin responses (SSRs) as controls. In the SCI group, all but one patient had reproducible hand SSRs. None of these patients had ECA or foot SSRs. All the PS patients had reproducible ECA and SSRs, both preoperatively and postoperatively. There was no difference in the latency and amplitude measurements of ECA and SSRs in the postoperative compared with that of the pre-operative period (P>0.05). In conclusion, ECA is absent in men with SCI above the sympathetic outflow to the genitalia. In men, after radical pelvic surgery, ECA is preserved, indicating the preservation of sympathetic fibers.

  6. Varying clinical presentations of familial cerebral cavernous malformations (CCMs) and spinal cord cavernous malformations (SCCMs).

    Science.gov (United States)

    Nicholas-Bublick, Selena; Koffman, Boyd M

    2012-01-01

    We present a family afflicted by both extensive cerebral cavernous malformations (CCMs) and spinal cord cavernous malformations (SCCMs). These may be inherited in an autosomal dominant pattern or occur sporadically. The presentation varies and may include a multitude of clinical symptoms separated in time and space. Cavernous malformations should be considered in the differential diagnosis of such entities as stroke, headache, multiple sclerosis, and new-onset seizures after an intraparenchymal hemorrhage.

  7. Varying clinical presentations of familial cerebral cavernous malformations (CCMs) and spinal cord cavernous malformations (SCCMs)

    OpenAIRE

    Nicholas-Bublick, Selena; Koffman, Boyd M.

    2015-01-01

    We present a family afflicted by both extensive cerebral cavernous malformations (CCMs) and spinal cord cavernous malformations (SCCMs). These may be inherited in an autosomal dominant pattern or occur sporadically. The presentation varies and may include a multitude of clinical symptoms separated in time and space. Cavernous malformations should be considered in the differential diagnosis of such entities as stroke, headache, multiple sclerosis, and new-onset seizures after an intraparenchym...

  8. Optochiasmatic cavernous angioma: unexpected diagnosis. Case report.

    Science.gov (United States)

    Ozer, Ercan; Kalemci, Orhan; Yücesoy, Kemal; Canda, Serafettin

    2007-03-01

    A 15-year-old boy presented with an extremely rare optochiasmatic cavernous angioma. He was admitted to a special hospital with the complaint of blurred vision persisting for 1 month. Magnetic resonance imaging and biopsy of the lesion were inconclusive. He was admitted to our neurosurgical clinic after worsening of the visual symptoms 9 months later. Repeat magnetic resonance imaging showed optochiasmatic cavernous angioma which had doubled in size. The lesion was removed completely without any problem. Postoperatively his visual complaints remained stable, but had improved after 1 year. Optochiasmatic cavernous malformation should be treated by surgical excision, whereas biopsy is useless and may result in enlargement.

  9. Anatomical landmarks for registration of experimental image data to volumetric rodent brain atlasing templates.

    Science.gov (United States)

    Sergejeva, Marina; Papp, Eszter A; Bakker, Rembrandt; Gaudnek, Manuel A; Okamura-Oho, Yuko; Boline, Jyl; Bjaalie, Jan G; Hess, Andreas

    2015-01-30

    Assignment of anatomical reference is a key step in integration of the rapidly expanding collection of rodent brain data. Landmark-based registration facilitates spatial anchoring of diverse types of data not suitable for automated methods operating on voxel-based image information. Here we propose a standardized set of anatomical landmarks for registration of whole brain imaging datasets from the mouse and rat brain, and in particular for integration of experimental image data in Waxholm Space (WHS). Sixteen internal landmarks of the C57BL/6J mouse brain have been reliably identified: by different individuals, independent of their experience in anatomy; across different MRI contrasts (T1, T2, T2(*)) and other modalities (Nissl histology and block-face anatomy); in different specimens; in different slice acquisition angles; and in different image resolutions. We present a registration example between T1-weighted MRI and the mouse WHS template using these landmarks and reaching fairly high accuracy. Landmark positions identified in the mouse WHS template are shared through the Scalable Brain Atlas, accompanied by graphical and textual guidelines for locating each landmark. We identified 14 of the 16 landmarks in the WHS template for the Sprague Dawley rat. This landmark set can withstand substantial differences in acquisition angle, imaging modality, and is less vulnerable to subjectivity. This facilitates registration of multimodal 3D brain data to standard coordinate spaces for mouse and rat brain taking a step toward the creation of a common rodent reference system; raising data sharing to a qualitatively higher level. Copyright © 2014 Elsevier B.V. All rights reserved.

  10. Extradural transcavernous approach to cavernous sinus cavernous hemangiomas.

    Science.gov (United States)

    Li, Mei-Hua; Zhao, Jian-Lan; Li, Yi-Yun; Zeng, Chun-Hui; Xu, Geng-Sheng; Hong, Tao

    2015-09-01

    Cavernous sinus cavernous hemangioma (CSCH) is a rare extra-axial vascular lesion and is difficult to be removed due to their location, propensity for profuse bleeding during surgery, and relationship to complex neurovascular structures. The purpose of this study is to report our experience of the removal of CSCHs through a completely extradural transcavernous approach. Twelve patients with CSCH, who were operated through a purely extradural approach, were retrospectively studied. Clinical symptoms and signs, radiographic characteristics, operative techniques and outcomes of these patients were analyzed. Headache and visual impairment were the most common clinical symptoms, followed by facial hypesthesia and ptosis. Radiographically, CSCHs have a characteristic pattern. On computed tomography (CT) scans, CSCHs are isodense or minimally hyperdense, with an intense homogenous contrast administration. Magnetic resonance image (MRI) scans revealed well-demarcated and hypo- to isointense lesions on T1-weighted images and characteristically, markedly hyperintense lesions on T2-weighted images. The T2-weighted images showed a marked homogeneous and an intense enhancement after contrast administration. All CSCHs were treated by a completely extradural transcavernous approach. Gross total excision was achieved in all 12 patients. Post-operative complication included transient cranial nerve dysfunction for 2-3 months in eight patients, and three patients developed a permanent VI nerve palsy. The follow-up period ranged from 4 to 117 months (mean 62 months), and no patient had experienced tumor recurrence. CSCHs are rare and challenging skull base tumors. The microsurgical resection, using an extradural transcavernous approach which allows complete tumor resection with an acceptable intraoperative and postoperative complications, should be considered as a favorable choice among all treatments. Copyright © 2015 Elsevier B.V. All rights reserved.

  11. Cerebral cavernous malformation proteins at a glance

    National Research Council Canada - National Science Library

    Draheim, Kyle M; Fisher, Oriana S; Boggon, Titus J; Calderwood, David A

    2014-01-01

    ...) cause cerebral cavernous malformations (CCMs). These abnormalities are characterized by dilated leaky blood vessels, especially in the neurovasculature, that result in increased risk of stroke, focal neurological defects and seizures...

  12. End of construction of the CMS cavern

    CERN Multimedia

    Maximilien Brice

    2005-01-01

    View of the CMS cavern with its impressive dimensions: 53 m long, 27 m wide and 24 m high. The construction of this underground complex has been a spectacular feat of engineering. This second of the new caverns for the LHC experiments is the result of six-and-a-half years of work, and its completion marks the end of the large-scale engineering work for the LHC.

  13. 10 janvier 2014 - A. Kilani, Ambassadeur Représentant permanent de la Tunisie auprès de l'Office des Nations Unies à Genève et des institutions spécialisées en Suisse visite la caverne de l'expérience ATLAS avec P. Jenni, ancien porte-parole d'ATLAS; visite le tunnel du LHC au Point 1 avec J.M. Jiménez, Chef du Département Technologie et signe le livre d'or avec F. Bordry, Directeur des accélérateurs et de la technologie. P. Fassnacht, Bureau des Relations internationales, Conseiller pour la République tunisienne présent.

    CERN Multimedia

    Jean-Claude, Gadmer

    2014-01-01

    10 janvier 2014 - A. Kilani, Ambassadeur Représentant permanent de la Tunisie auprès de l'Office des Nations Unies à Genève et des institutions spécialisées en Suisse visite la caverne de l'expérience ATLAS avec P. Jenni, ancien porte-parole d'ATLAS; visite le tunnel du LHC au Point 1 avec J.M. Jiménez, Chef du Département Technologie et signe le livre d'or avec F. Bordry, Directeur des accélérateurs et de la technologie. P. Fassnacht, Bureau des Relations internationales, Conseiller pour la République tunisienne présent.

  14. Unilateral Direct Carotid Cavernous Fistula Causing Bilateral Ocular Manifestation.

    Science.gov (United States)

    Demartini, Zeferino; Liebert, Fernando; Gatto, Luana Antunes Maranha; Jung, Thiago Simiano; Rocha, Carlos; Santos, Alex Marques Borges; Koppe, Gelson Luis

    2015-01-01

    Unilateral carotid cavernous fistula presents with ipsilateral ocular findings. Bilateral presentation is only seen in bilateral fistulas, usually associated with indirect (dural) carotid cavernous fistulas. Direct carotid cavernous fistulas are an abnormal communication between the internal carotid artery and the cavernous sinus. They typically begin with a traumatic disruption in the artery wall into the cavernous sinus, presenting with a classic triad of unilateral pulsatile exophthalmos, cranial bruit and episcleral venous engorgement. We report the case of a 38-year-old male with traumatic right carotid cavernous sinus fistula and bilateral ocular presentation successfully treated by interventional neuroradiology.

  15. Superficial Siderosis Associated with Pineal Cavernous Malformation.

    Science.gov (United States)

    Ogura, Takafumi; Kambe, Atsushi; Sakamoto, Makoto; Shinohara, Yuki; Ogawa, Toshihide; Kurosaki, Masamichi

    2018-01-01

    Cavernous malformations in the pineal region are rare and difficult to anticipate from preoperative evaluation in patients with pineal apoplexy. We herein report the first case of a pineal cavernous malformation with superficial siderosis. Radiological findings were helpful in identifying the presence of the cavernous malformation. A 47-year-old female presented with a 4-month history of progressive headache, nausea, and dizziness. She complained of double vision and exhibited upward gaze palsy and papilledema on fundoscopy. Radiological examination revealed subacute hemorrhage in the pineal region and enlarged lateral ventricles. Furthermore, T2-star-weighted gradient-echo magnetic resonance imaging demonstrated a linear hypointensity along the pial surface of the cerebral cortex, brainstem, and cerebellum, indicating hemosiderin deposition consistent with superficial siderosis. Suspecting the presence of a cavernous malformation based on the radiological findings of superficial siderosis, we performed total mass resection. The postoperative course was uneventful and her preoperative symptoms resolved completely. Radiological findings of superficial siderosis on T2-star-weighted gradient-echo imaging are useful to making a diagnosis of cavernous malformation in cases of pineal apoplexy. They are also important for making the treatment decision to perform total mass resection, which is the best curative method for pineal cavernous malformations. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. Radiology and imaging for cavernous malformations.

    Science.gov (United States)

    Wang, Kevin Y; Idowu, Oluwatoyin R; Lin, Doris D M

    2017-01-01

    Cavernous malformations are low-flow vascular malformations that are histologically characterized by the lack of mural elements of mature vascular structures and intervening parenchymal neural tissue. They are often clinically quiescent, and may grow, bleed, and regress, but can also manifest clinically as neurologic deficits or seizures in the setting of an acute hemorrhage. The low-flow nature of cavernous malformations renders them inherently occult on cerebral angiography. Magnetic resonance imaging has become the mainstay imaging modality in evaluating cavernous malformations, producing characteristic imaging features that usually provide a straightforward diagnosis. Features on magnetic resonance imaging include a reticulated pattern of mixed hyper- and hypointensity on T1- and T2-weighted imaging, with a characteristic hypointense rim best appreciated on T2-weighted imaging or gradient-echo sequences. Contrast enhancement is useful for revealing coexisting developmental venous anomalies that are frequently associated with sporadic cavernous malformations, and may further support the diagnosis. Susceptibility-weighted imaging is highly sensitive for cavernous malformations and accompanying developmental venous anomalies, and is superior to gradient-echo sequences in screening for multifocal, familial cavernous malformations. © 2017 Elsevier B.V. All rights reserved.

  17. The Measurement of Spectral Characteristics and Composition of Radiation in ATLAS with MEDIPIX2-USB Devices

    CERN Document Server

    Campbell, M.; Greiffenberg, D.; Heijne, E.; Holy, T.; Idárraga, J.; Jakubek, J.; Král, V.; Králík, M.; Lebel, C.; Leroy, C.; Llopart, X.; Lord, G.; Maneuski, D.; Ouellette, O.; Sochor, V.; Prospísil, S.; Suk, M; Tlustos, L.; Vykydal, Z.; Wilhelm, I.

    2008-01-01

    A network of devices to perform real-time measurements of the spectral characteristics and composition of radiation in the ATLAS detector and cavern during its operation is being built. This system of detectors will be a stand alone system fully capable of delivering real-time images of fluxes and spectral composition of different particle species including slow and fast neutrons. The devices are based on MEDIPIX2 pixel silicon detectors that will be operated via active USB cables and USB-Ethernet extenders through an Ethernet network by a PC located in the USA15 ATLAS control room. The installation of 14 devices inside ATLAS (detector and cavern) is in progress.

  18. The ATLAS ALFA and AFP detectors - the experimental challenge of measuring forward protons at the LHC

    CERN Document Server

    Trzebinski, M; The ATLAS collaboration

    2013-01-01

    The Absolute Luminosity For ATLAS (ALFA) and ATLAS Forward Protons (AFP) detectors are introduced. The forward proton trajectories are shown. The similarities and differences between these two detector systems are described. Finally, the physics possible to be done in these forward detectors is discussed. In particular, in case of ALFA the elastic scattering and exclusive di-pion production are described. In case of AFP, the hard diffractive processes like: Single Diffractive Jet, Double Pomeron Exchange Jet, Exclusive Jet and anomalous coupling production are described.

  19. ATLAS Silicon Microstrip Tracker Operation and Performance

    CERN Document Server

    Chalupkova, I; The ATLAS collaboration

    2012-01-01

    The Semi-Conductor Tracker (SCT) is a silicon strip detector and one of the key precision tracking devices in the Inner Detector (ID) of the ATLAS experiment at CERN LHC. The SCT is constructed of 4088 silicon detector modules with a total of 6.3 million strips. Each module is designed, constructed and tested to operate as a stand-alone unit, mechanically, electrically, optically and thermally. The modules are mounted into two types of structures: one barrel (4 cylinders) and two end-cap systems (9 disks on each side of the barrel). The SCT silicon microstrip sensors are processed in the planar p-in-n technology. The signals from the strips are processed in the front-end ASICs ABCD3TA, working in the binary readout mode. Data is transferred to the off-detector readout electronics via optical fibres. SCT has been installed inside the ATLAS experimental cavern since 2007 and has been operational ever since. Calibration data has been taken regularly and analysed to determine the noise performance of the system. ...

  20. ATLAS Silicon Microstrip Tracker Operation and Performance

    CERN Document Server

    Johansson, Per; The ATLAS collaboration

    2012-01-01

    The Semi-Conductor Tracker (SCT) is a silicon strip detector and one of the key precision tracking devices in the Inner Detector of the ATLAS experiment at CERN LHC. The SCT is constructed of 4088 silicon detector modules for a total of 6.3 million strips. Each module is designed, constructed and tested to operate as a stand-alone unit, mechanically, electrically, optically and thermally. The modules are mounted into two types of structures: one barrel (4 cylinders) and two end-cap systems (9 disks on each end of the barrel). The SCT silicon micro-strip sensors are processed in the planar p-in-n technology. The signals from the strips are processed in the front-end ASICS ABCD3TA, working in the binary readout mode. Data is transferred to the off-detector readout electronics via optical fibers. The completed SCT has been installed inside the ATLAS experimental cavern since 2007 and has been operational since then. Calibration data has been taken regularly and analyzed to determine the noise performance of the ...

  1. ATLAS Silicon Microstrip Tracker Operation and Performance

    CERN Document Server

    NAGAI, K; The ATLAS collaboration

    2012-01-01

    The Semi-Conductor Tracker (SCT) is a silicon strip detector and one of the key precision tracking devices in the Inner Detector of the ATLAS experiment at CERN LHC. The SCT is constructed of 4088 silicon detector modules for a total of 6.3 million strips. Each module is designed, constructed and tested to operate as a stand-alone unit, mechanically, electrically, optically and thermally. The modules are mounted into two types of structures: one barrel (4 cylinders) and two end-cap systems (9 disks on each end of the barrel). The SCT silicon micro-strip sensors are processed in the planar p-in-n technology. The signals from the strips are processed in the front-end ASICS ABCD3TA, working in the binary readout mode. Data is transferred to the off-detector readout electronics via optical fibres. The completed SCT has been installed inside the ATLAS experimental cavern since 2007 and has been operational since then. Calibration data has been taken regularly and analysed to determine the noise performance of the ...

  2. LS1 Report: Handing in the ATLAS keys

    CERN Multimedia

    Antonella Del Rosso, Katarina Anthony

    2014-01-01

    After completing more than 250 work packages concerning the whole detector and experimental site, the ATLAS and CERN teams involved with LS1 operations are now wrapping things up before starting the commissioning phase in preparation for the LHC restart. The giant detector is now more efficient, safer and even greener than ever thanks to the huge amount of work carried out over the past two years.   Cleaning up the ATLAS cavern and detector in preparation for Run 2. Hundreds of people, more than 3000 certified interventions, huge and delicate parts of the detector completely refurbished: the ATLAS detector that will take data during Run 2 is a brand new machine, which will soon be back in the hands of the thousands of scientists who are preparing for the high-energy run of the LHC accelerator. “During LS1, we have upgraded the detector’s basic infrastructure and a few of its sub-detectors,” explains Beniamino Di Girolamo, ATLAS Technical Coordinator. &...

  3. An interesting case of angiogenesis in cavernous hemangioma

    Directory of Open Access Journals (Sweden)

    Dipankar Das

    2016-01-01

    Full Text Available Cavernous hemangioma is the most common orbital tumor in adult. There is lot of literatures for clinicopathological features of this tumor. These tumors had been studied for the model of angiogenesis in many of the experimental setups. We present a case of 34-year-old male with this tumor in the left eye with computerized tomography evidence. Postsurgical laboratory findings gave interesting evidence of tumor angiogenesis with tumor endothelial cells and sprouting of the small vessels endothelial cells. Podosome rosette could be conceptualized from the characteristic patterns seen in the tumor.

  4. Analysis of cavern stability at the West Hackberry SPR site.

    Energy Technology Data Exchange (ETDEWEB)

    Ehgartner, Brian L.; Sobolik, Steven Ronald

    2009-05-01

    This report presents computational analyses that simulate the structural response of caverns at the Strategic Petroleum Reserve (SPR) West Hackberry site. The cavern field comprises 22 caverns. Five caverns (6, 7, 8, 9, 11) were acquired from industry and have unusual shapes and a history dating back to 1946. The other 17 caverns (101-117) were leached according to SPR standards in the mid-1980s and have tall cylindrical shapes. The history of the caverns and their shapes are simulated in a three-dimensional geomechanics model of the site that predicts deformations, strains, and stresses. Future leaching scenarios corresponding to oil drawdowns using fresh water are also simulated by increasing the volume of the caverns. Cavern pressures are varied in the model to capture operational practices in the field. The results of the finite element model are interpreted to provide information on the current and future status of subsidence, well integrity, and cavern stability. The most significant results in this report are relevant to Cavern 6. The cavern is shaped like a bowl with a large ceiling span and is in close proximity to Cavern 9. The analyses predict tensile stresses at the edge of the ceiling during repressuization of Cavern 6 following workover conditions. During a workover the cavern is at low pressure to service a well. The wellhead pressures are atmospheric. When the workover is complete, the cavern is repressurized. The resulting elastic stresses are sufficient to cause tension around the edge of the large ceiling span. With time, these stresses relax to a compressive state because of salt creep. However, the potential for salt fracture and propagation exists, particularly towards Cavern 9. With only 200 ft of salt between the caverns, the operational consequences must be examined if the two caverns become connected. A critical time may be during a workover of Cavern 9 in part because of the operational vulnerabilities, but also because dilatant damage is

  5. The imaging of conditions affecting the cavernous sinus

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Y., E-mail: yenzhitang@doctors.net.u [Royal Free Hospital, Pond Street London NW32QG (United Kingdom); Booth, T.; Steward, M.; Solbach, T.; Wilhelm, T. [Royal Free Hospital, Pond Street London NW32QG (United Kingdom)

    2010-11-15

    The cavernous sinus can be affected by a wide range of conditions including tumours, infection, inflammation, and trauma. Disease in the cavernous sinus can produce characteristic signs and symptoms, which relate to the numerous crucial structures traversing and surrounding the cavernous sinus. Imaging, with the use of different techniques, plays a crucial role in diagnosis and management. The anatomy and imaging of the different disease entities in the cavernous sinus will be reviewed.

  6. Convexity dural cavernous haemangioma mimicking meningioma: A case report.

    Science.gov (United States)

    Wang, Xiang; Liu, Jian-Ping; You, Chao; Mao, Qing

    2016-06-01

    Dural cavernous haemangiomas are rare, and they do not display a classical ring of haemosiderin on MRI as parenchymal cavernous haemangiomas. Sometimes, they are misinterpreted as meningiomas with a dural tail sign. In this short report, a 37-year-old woman was diagnosed with a convexity cavernous haemangioma, and the tumour was totally resected.

  7. DURAL CAROTID-CAVERNOUS FISTULAS

    Directory of Open Access Journals (Sweden)

    Barbara Cvenkel

    2002-12-01

    Full Text Available Background. Dural carotid-cavernous sinus fistulas (CCF are communications fed by meningeal branches of the intracavernous internal carotid artery (ACI or/and external carotid artery (ACE. In contrast to typical CCF, the arteriovenous shunting of blood is usually low flow and low pressure. Spontaneous dural CCF are more common in postmenopausal women. Aetiology is unknown, but congenital malformation or rupture of thin-walled dural arteries within venous sinuses is believed to be the cause.Case reports. 3 cases lacking the typical clinical signs of CCF who had been treated as chronic conjunctivitis, myositis of the extraocular muscle and orbital pseudotumour are presented. Clinical presentation depends on the direction and magnitude of fistular flow and on the anatomy of the collateral branches. If increased blood flow is directed anteriorly in ophthalmic veins the signs of orbito-ocular congestion are present (»redeyed shunt syndrome«. Drainage primarly in the inferior petrosal sinus may cause painful oculomotor and abducens palsies without signs of ocular congestion (»white-eyed shunt syndrome«. Also different therapeutic approaches as well as possible complications are described.Conclusions. For definite diagnosis angiography is obligatory and is also therapeutic as one third to one half of dural CCF close spontaneously. Because of potential severe eye and systemic complications, surgical intervention is indicated only in cases with uncontrolled secondary glaucoma and hypoxic retinopathy.

  8. Analysis of cavern stability at the Bryan Mound SPR site.

    Energy Technology Data Exchange (ETDEWEB)

    Ehgartner, Brian L.; Sobolik, Steven Ronald

    2009-04-01

    This report presents computational analyses that simulate the structural response of caverns at the Strategic Petroleum Reserve Bryan Mound site. The cavern field comprises 20 caverns. Five caverns (1, 2, 4, and 5; 3 was later plugged and abandoned) were acquired from industry and have unusual shapes and a history dating back to 1946. The other 16 caverns (101-116) were leached according to SPR standards in the mid-1980s and have tall cylindrical shapes. The history of the caverns and their shapes are simulated in a 3-D geomechanics model of the site that predicts deformations, strains, and stresses. Future leaching scenarios due to oil drawdowns using fresh water are also simulated by increasing the volume of the caverns. Cavern pressures are varied in the model to capture operational practices in the field. The results of the finite element model are interpreted to provide information on the current and future status of subsidence, well integrity, and cavern stability. The most significant result in this report is relevant to caverns 1, 2, and 5. The caverns have non-cylindrical shapes and have potential regions where the surrounding salt may be damaged during workover procedures. During a workover the normal cavern operating pressure is lowered to service a well. At this point the wellhead pressures are atmospheric. When the workover is complete, the cavern is repressurized. The resulting elastic stresses are sufficient to cause tension and large deviatoric stresses at several locations. With time, these stresses relax to a compressive state due to salt creep. However, the potential for salt damage and fracturing exists. The analyses predict tensile stresses at locations with sharp-edges in the wall geometry, or in the case of cavern 5, in the neck region between the upper and lower lobes of the cavern. The effects do not appear to be large-scale, however, so the only major impact is the potential for stress-induced salt falls in cavern 5, potentially leading to

  9. Analysis of cavern shapes for the strategic petroleum reserve.

    Energy Technology Data Exchange (ETDEWEB)

    Ehgartner, Brian L.; Sobolik, Steven Ronald

    2006-07-01

    This report presents computational analyses to determine the structural integrity of different salt cavern shapes. Three characteristic shapes for increasing cavern volumes are evaluated and compared to the baseline shape of a cylindrical cavern. Caverns with enlarged tops, bottoms, and mid-sections are modeled. The results address pillar to diameter ratios of some existing caverns in the system and will represent the final shape of other caverns if they are repeatedly drawn down. This deliverable is performed in support of the U.S. Strategic Petroleum Reserve. Several three-dimensional models using a close-packed arrangement of 19 caverns have been built and analyzed using a simplified symmetry involving a 30-degree wedge portion of the model. This approach has been used previously for West Hackberry (Ehgartner and Sobolik, 2002) and Big Hill (Park et al., 2005) analyses. A stratigraphy based on the Big Hill site has been incorporated into the model. The caverns are modeled without wells and casing to simplify the calculations. These calculations have been made using the power law creep model. The four cavern shapes were evaluated at several different cavern radii against four design factors. These factors included the dilatant damage safety factor in salt, the cavern volume closure, axial well strain in the caprock, and surface subsidence. The relative performance of each of the cavern shapes varies for the different design factors, although it is apparent that the enlarged bottom design provides the worst overall performance. The results of the calculations are put in the context of the history of cavern analyses assuming cylindrical caverns, and how these results affect previous understanding of cavern behavior in a salt dome.

  10. MR imaging of cerebral cavernous hemangiomas

    Energy Technology Data Exchange (ETDEWEB)

    Shakudo, Miyuki; Inoue, Yuichi; Matsumura, Yasumasa and others

    1988-06-01

    Magnetic resonance imaging (MRI) and CT were performed on 16 lesions of 13 patients with cases of cavernous hemangioma (10 cases of a solitary lesion and 1 case of multiple lesions). Six of the 16 cavernomas were histologically confirmed. All the lesions were detected on enhanced CT scans; fifteen of the 16 lesions were detected on MR images. The cavernous hemangiomas showed various signal intensities on both T/sub 1/-weighted and T/sub 2/-weighted images. All lesions not associated with a fresh hematoma were circumscribed by a curvilinear low-intensity area, most prominently on T/sub 2/-weighted images. This low-intensity band around cavernous hemangiomas on T/sub 2/-weighted images seemed to represent the hemosiderin leiden peritumoral brain.

  11. 9 July 2008 - Microsoft Co-Founder P. Allen visiting ATLAS control room and underground experimental area with Adviser J. Ellis and IT Department Head W. von Rüden.

    CERN Multimedia

    Maximilien Brice

    2008-01-01

    9 July 2008 - Microsoft Co-Founder P. Allen visiting ATLAS control room and underground experimental area with Adviser J. Ellis and IT Department Head W. von Rüden and guided by ATLAS Collaboration Users S. Goldfarb, P. Nevski and L. Price.

  12. Dural cavernous haemangioma of posterior cranial fossa.

    Directory of Open Access Journals (Sweden)

    Goel A

    1993-10-01

    Full Text Available A rare case of extracerebral dural cavernous angioma sited near the sigmoid sinus is reported. This 60 yr old male patient gave history of episodic ataxia of left sided limbs experienced twice on same day and occasional giddiness. Examination did not reveal any findings. A mass was diagnosed on CT Scan following which angiography was carried out. The features matched with those of a meningioma. Retro-sigmoid craniectomy was performed. Occipital artery was coagulated. Tumor was dissected out. Post-operative course of the patient was uneventful. Histopathology revealed that the mass was a cavernous haemangioma.

  13. Cavernous haemangioma mimicking as clitoral hypertrophy

    Directory of Open Access Journals (Sweden)

    Sajid Nayyar

    2014-01-01

    Full Text Available Haemangioma is the most common benign neoplasm of infantile age. It is most commonly located in head and neck region, trunk and extremities but very rarely it can be located at clitoris. However, it is very important to differentiate clitoral haemangioma from enlargement of the clitoris secondary to androgen excess. Only four cases of clitoromegaly caused by cavernous haemangioma have been reported in the literature so far. Herein, we report our experience with a 10-year-old girl who presented with clitoromegaly and normal hormonal assay that turned out to be clitoral cavernous haemangioma after histopathological examination of the clitoral mass.

  14. 14 February 2012 - Ambassadors from Algeria, Brunei Darussalam, Canada, Chad, Tunisia, Permanent Representatives to the United Nations Office at Geneva in the LHC tunnel at Point 1, ATLAS visitor centre, and ATLAS underground experimental area, throughout accompanied by Advisers P. Fassnacht, E. Tsesmelis and R. Voss

    CERN Multimedia

    Jean-Claude Gadmer

    2012-01-01

    14 February 2012 - Ambassadors from Algeria, Brunei Darussalam, Canada, Chad, Tunisia, Permanent Representatives to the United Nations Office at Geneva in the LHC tunnel at Point 1, ATLAS visitor centre, and ATLAS underground experimental area, throughout accompanied by Advisers P. Fassnacht, E. Tsesmelis and R. Voss

  15. 27 February 2012 - German Secretary General, Volkswagen Foundation, W. Krull signing the guest book with Director for Administration and general infrastructure S. Lettow and International Relations Adviser R. Voss; in the ATLAS visitor centre and ATLAS underground experimental area with Collaboration Member T. Wengler.

    CERN Document Server

    Laurent Egli

    2012-01-01

    27 February 2012 - German Secretary General, Volkswagen Foundation, W. Krull signing the guest book with Director for Administration and general infrastructure S. Lettow and International Relations Adviser R. Voss; in the ATLAS visitor centre and ATLAS underground experimental area with Collaboration Member T. Wengler.

  16. Imaging diagnosis of dural and direct cavernous carotid fistulae*

    Science.gov (United States)

    dos Santos, Daniela; Monsignore, Lucas Moretti; Nakiri, Guilherme Seizem; Cruz, Antonio Augusto Velasco e; Colli, Benedicto Oscar; Abud, Daniel Giansante

    2014-01-01

    Arteriovenous fistulae of the cavernous sinus are rare and difficult to diagnose. They are classified into dural cavernous sinus fistulae or direct carotid-cavernous fistulae. Despite the similarity of symptoms between both types, a precise diagnosis is essential since the treatment is specific for each type of fistula. Imaging findings are remarkably similar in both dural cavernous sinus fistulae and carotid-cavernous fistulae, but it is possible to differentiate one type from the other. Amongst the available imaging methods (Doppler ultrasonography, computed tomography, magnetic resonance imaging and digital subtraction angiography), angiography is considered the gold standard for the diagnosis and classification of cavernous sinus arteriovenous fistulae. The present essay is aimed at didactically presenting the classification and imaging findings of cavernous sinus arteriovenous fistulae. PMID:25741093

  17. Imaging diagnosis of dural and direct cavernous carotid fistulae.

    Science.gov (United States)

    Dos Santos, Daniela; Monsignore, Lucas Moretti; Nakiri, Guilherme Seizem; Cruz, Antonio Augusto Velasco E; Colli, Benedicto Oscar; Abud, Daniel Giansante

    2014-01-01

    Arteriovenous fistulae of the cavernous sinus are rare and difficult to diagnose. They are classified into dural cavernous sinus fistulae or direct carotid-cavernous fistulae. Despite the similarity of symptoms between both types, a precise diagnosis is essential since the treatment is specific for each type of fistula. Imaging findings are remarkably similar in both dural cavernous sinus fistulae and carotid-cavernous fistulae, but it is possible to differentiate one type from the other. Amongst the available imaging methods (Doppler ultrasonography, computed tomography, magnetic resonance imaging and digital subtraction angiography), angiography is considered the gold standard for the diagnosis and classification of cavernous sinus arteriovenous fistulae. The present essay is aimed at didactically presenting the classification and imaging findings of cavernous sinus arteriovenous fistulae.

  18. Imaging diagnosis of dural and direct cavernous carotid fistulae

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Daniela dos; Monsignore, Lucas Moretti; Nakiri, Guilherme Seizem; Cruz, Antonio Augusto Velasco e; Colli, Benedicto Oscar; Abud, Daniel Giansante, E-mail: danisantos2404@gmail.com [Universidade de Sao Paulo (HCFMRP/USP), Ribeirao Preto, SP (Brazil). Faculdade de Medicina. Hospital das Clinicas

    2014-07-15

    Arteriovenous fistulae of the cavernous sinus are rare and difficult to diagnose. They are classified into dural cavernous sinus fistulae or direct carotid-cavernous fistulae. Despite the similarity of symptoms between both types, a precise diagnosis is essential since the treatment is specific for each type of fistula. Imaging findings are remarkably similar in both dural cavernous sinus fistulae and carotid-cavernous fistulae, but it is possible to differentiate one type from the other. Amongst the available imaging methods (Doppler ultrasonography, computed tomography, magnetic resonance imaging and digital subtraction angiography), angiography is considered the gold standard for the diagnosis and classification of cavernous sinus arteriovenous fistulae. The present essay is aimed at didactically presenting the classification and imaging findings of cavernous sinus arteriovenous fistulae. (author)

  19. ATLAS experiment : From virtual world to real world

    CERN Multimedia

    CERN ATLAS

    2005-01-01

    The film is a combination of three dimensional cad-based animations together with the real film taken with webcams during the construction, lowering and installation of elements belonging to ATLAS Detector. Very nice movie that gives the view of the both planning and real construction of this huge detector complex located in underground cavern in POINT1. This movie is worth to see!

  20. Transplantation of Muscle-Derived Stem Cells into the Corpus Cavernosum Restores Erectile Function in a Rat Model of Cavernous Nerve Injury

    OpenAIRE

    Woo, Jang Chun; Bae, Woong Jin; Kim, Su Jin; Kim, Sung Dae; Sohn, Dong Wan; Hong, Sung Hoo; Lee, Ji Youl; Hwang, Tae-Kon; Sung, Young Chul; Kim, Sae Woong

    2011-01-01

    Purpose Muscle-derived stem cells (MDSCs) harvested from skeletal muscles have the advantage of providing easier access and do not pose the immunogenic risks of embryonic stem cells. We investigated the effect of intracavernosal transplantation of MDSCs on erectile function in rats with bilateral cavernous nerve injury. Materials and Methods Adult male white rats underwent experimentation in 3 groups: group I, sham operation; group II, bilateral cavernous nerve injury; group III, bilateral ca...

  1. Endoscopic Endonasal Approach to Mesencephalic Cavernous Malformations.

    Science.gov (United States)

    He, Shi-Ming; Wang, Yuan; Zhao, Tian-Zhi; Zheng, Tao; Lv, Wen-Hai; Zhao, Lan-Fu; Chen, Long; Sterling, Cole; Qu, Yan; Gao, Guo-Dong

    2016-06-01

    Symptomatic cavernous malformations involving the brainstem are difficult to access by conventional approaches, which often require dramatic brain retraction to gain adequate operative corridor. Here, we present a successful endoscopic endonasal transclival approach for resection of a hemorrhagic, symptomatic mesencephalic cavernous malformation. A 20-year-old woman presented with acute onset of headache, nausea, and vomiting. Computed tomography scan revealed a ventral midbrain hemorrhage. On day 3 of admission, the patient developed left-sided hemiparesis, restriction of medial and lateral left-eye movements, and loss of left pupillary light reflex. Subsequent magnetic resonance imaging demonstrated an increase of the midbrain lesion to 1.2 cm × 1.7 cm. Diffusion tensor imaging showed compression and lateral displacement of the right corticospinal tract near the thalamus and cerebral peduncle. Given the patient's clinical presentation and the findings on imaging, we suspected a mesencephalic cavernous malformation. The patient underwent an endoscopic endonasal transclival resection of a ventral midline mesencephalon cavernous malformation. A dark red lesion was directly visualized under the endoscope. After a small cortiectomy, the pial and perforator vessels were dissected, and dark-brown blood was drained from the cavernoma cavity. Using a biopsy forceps and with careful attention to the cavernoma borders, the lesion was removed and hemostasis was achieved. Pathologic examination confirmed cavernous malformation. One week after the operation, magnetic resonance imaging demonstrated total resection of the lesion. A 3-month follow-up revealed improved neurologic symptoms with minimal surgical morbidity. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. 24 January 2011 - President of the Deutsche Forschungsgemeinschaft M. Kleiner in the ATLAS visitor centre and underground experimental area with Former Spokesperson P. Jenni, accompanied by P. Mättig and Adviser R. Voss.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    24 January 2011 - President of the Deutsche Forschungsgemeinschaft M. Kleiner in the ATLAS visitor centre and underground experimental area with Former Spokesperson P. Jenni, accompanied by P. Mättig and Adviser R. Voss.

  3. 17 May 2013 - Honourable Minister of Communications, Science and Technology of the Kingdom of Lesotho T. Mokhosi visiting the ATLAS experimental area with CERN International Adviser for Turkey R. Voss.

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    17 May 2013 - Honourable Minister of Communications, Science and Technology of the Kingdom of Lesotho T. Mokhosi visiting the ATLAS experimental area with CERN International Adviser for Turkey R. Voss.

  4. ATLAS Forward Detectors and Physics

    CERN Document Server

    Soni, N

    2010-01-01

    In this communication I describe the ATLAS forward physics program and the detectors, LUCID, ZDC and ALFA that have been designed to meet this experimental challenge. In addition to their primary role in the determination of ATLAS luminosity these detectors - in conjunction with the main ATLAS detector - will be used to study soft QCD and diffractive physics in the initial low luminosity phase of ATLAS running. Finally, I will briefly describe the ATLAS Forward Proton (AFP) project that currently represents the future of the ATLAS forward physics program.

  5. ATLAS and its eight torodial magnets

    CERN Multimedia

    Maximilien Brice

    2005-01-01

    The ATLAS detector is a huge device. Standing at 25 m tall, when complete it will be the largest detector of its type in the world. The main barrel is yet to be installed giving impressive views of the eight torodial magnets while scaffolding is still in place to allow technicians to work on the detector as it is assembled in its cathedral-like cavern.

  6. ATLAS Civil Engineering Point 1

    CERN Multimedia

    Jean-Claude Vialis

    1999-01-01

    Different phases of realisation to Point 1 : zone of the ATLAS experiment The ATLAS experimental area is located in Point 1, just across the main CERN entrance, in the commune of Meyrin. There people are ever so busy to finish the different infrastructures for ATLAS. Real underground video. The film has original working sound.

  7. Last piece of ATLAS takes the plunge

    CERN Multimedia

    2008-01-01

    On Friday 29 February the second small wheel was lowered 100 metres underground into the ATLAS cavern in front of a captivated audience. Although called the "small wheels" they are small in name only - each wheel is 9.3 metres in diameter and weighs 100 tonnes including the massive shielding elements. This piece completes ATLAS’ muon spectrometer, which has the ability to accurately track particles to the width of a human hair. The first piece of ATLAS was installed in 2003 and, five years later, this small wheel is the final large piece of the detector to take the subterranean voyage to its final resting place.

  8. Hundreds of fridges to cool the heart of ATLAS

    CERN Multimedia

    2006-01-01

    The detectors used in the LHC experiments are packed with electronics that will register thousands of particles produced in the collisions. All this hard work will generate a lot of heat, but there are systems in place to help the electronics to cool down, not shut down. Members of the DC section team in USA15 of the ATLAS cavern, standing behind four of the compressors used in the cooling system. The inlet and outlet pipes that carry the refrigerant to the experimental hall can be seen on the left. Left to right: M. Battistin, P. Bonneau, C. Houd, P. Feraudet, F. Corbaz, J. Lethinen, P. Guglielmini, M. Ciclet, P. Tropea, S. Berry (M. Pimenta absent).An unconfirmed member of the DC section :-) in charge of a part of the perfluoropropane distribution network for the ATLAS evaporative cooling system. The next time your desktop computer crashes from overheating, spare a thought for Pierre Feraudet, a member of the Detector Cooling section (TS/CV/DC). He is in charge of constructing the cooling systems for the d...

  9. The Energy Response of the ATLAS Calorimeter System

    CERN Document Server

    Schlager, G; Carli, T; Fabjan, Christian Wolfgang; Henriques, A

    2006-01-01

    The Large Hadron Collider (LHC) currently under construction at the European Organization for Nuclear Research (CERN) in Geneva will collide two proton beams with a center-of-mass energy of 14 TeV. At this high energy frontier a new chapter of particle physics will be opened. The ATLAS experiment is a general-purpose LHC detector for proton-proton collisions. The electromagnetic liquid argon-lead sampling calorimeter (LAr Calorimeter) is designed to measure the energy and position of electrons and photons with high precision and the hadronic scintillator-iron sampling calorimeter (TileCal) complements the measurement of the energy and direction of jets. Both calorimeters are installed in the ATLAS experimental cavern and are presently being commissioned. To be able to start the commissioning of the TileCal in an early phase, even before the final electronic readout system was available, a mobile data acquisition system (MobiDAQ) was developed in the context of this PhD-thesis. It is capable of reading up to e...

  10. Cavernous venous malformation (cavernous hemangioma) of the orbit: Current concepts and a review of the literature.

    Science.gov (United States)

    Calandriello, Luigi; Grimaldi, Gabriela; Petrone, Gianluigi; Rigante, Mario; Petroni, Sergio; Riso, Monica; Savino, Gustavo

    The cavernous venous malformation of the orbit, previously called cavernous hemangioma, is the most common primary orbital lesion of adults. Cavernous venous malformation occurs more often in women and typically presents in the fourth and fifth decades of life. It is a benign vascular malformation characterized by a well-defined capsule and numerous large vascular channels. The most common sign of cavernous venous malformation is progressive axial proptosis from the preferential involvement of the intraconal orbital space. Optic nerve damage and other signs of orbital pathology may be present, with a variable degree of visual impairment. The combination of ultrasound, computed tomography, and magnetic resonance imaging leads to an accurate diagnosis in the vast majority of cases. Surgical and nonsurgical treatments are required in case of symptomatic lesions, with a characteristic multidisciplinary management influencing optimal outcome. Orbitotomy represents the traditional surgical approach. Recently, the endoscopic transnasal approach to the orbital cavity has gained interest, representing a feasible and safe, less-invasive surgical technique for the management of cavernous venous malformation. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. Coincident Giant Cavernous Angioma and Large Middle Cerebral Artery Aneurysm

    OpenAIRE

    Newton, Tom D.; Munusamy, Saravanan; Laitt, Roger

    2015-01-01

    Cavernous angiomas although relatively common lesions rarely reach a large size. They have a well documented association with AVMs, capillary telangiectases and venous angiomas but are not specifically associated with intracerebral aneurysms. We present a case of what we believe to be the 4th largest reported giant cavernous angioma to present in adulthood. This cavernous angioma also happened to be associated with a large intracerebral aneurysm, an association not previously reported. The so...

  12. Alan Alda visits the ATLAS Experiment cavern at CERN

    CERN Multimedia

    Claudia Marcelloni

    2012-01-01

    Alan Alda, is an American actor, director, screenwriter, and author. A six-time Emmy Award and Golden Globe Award winner, he is best known for his role as Hawkeye Pierce in the TV series M*A*S*H. He is currently a Visiting Professor at the State University of New York at Stony Brook School of Journalism and a member of the advisory board of The Center for Communicating Science.[1

  13. Multiple intracranial cavernous angiomas: A rare case series

    Directory of Open Access Journals (Sweden)

    Pradeepgoud H Patil

    2012-01-01

    Full Text Available Cavernous angiomas are cerebral cavernous malformations and they are relatively rare lesions. Two forms of cavernous angiomas have been described: a sporadic form, in which patients usually have a single lesion, and a familial form, the hallmarks of which are multiple lesions and autosomal dominant transmission. The familial form appears to be very uncommon and has mainly been described in the Hispanic population. We report two cases of multiple intracranial cavernous angiomas which is an autosomal dominant pattern of inheritance. It is very rare to find this in non Hispanic population.

  14. Allowable pillar to diameter ratio for strategic petroleum reserve caverns.

    Energy Technology Data Exchange (ETDEWEB)

    Ehgartner, Brian L.; Park, Byoung Yoon

    2011-05-01

    This report compiles 3-D finite element analyses performed to evaluate the stability of Strategic Petroleum Reserve (SPR) caverns over multiple leach cycles. When oil is withdrawn from a cavern in salt using freshwater, the cavern enlarges. As a result, the pillar separating caverns in the SPR fields is reduced over time due to usage of the reserve. The enlarged cavern diameters and smaller pillars reduce underground stability. Advances in geomechanics modeling enable the allowable pillar to diameter ratio (P/D) to be defined. Prior to such modeling capabilities, the allowable P/D was established as 1.78 based on some very limited experience in other cavern fields. While appropriate for 1980, the ratio conservatively limits the allowable number of oil drawdowns and hence limits the overall utility and life of the SPR cavern field. Analyses from all four cavern fields are evaluated along with operating experience gained over the past 30 years to define a new P/D for the reserve. A new ratio of 1.0 is recommended. This ratio is applicable only to existing SPR caverns.

  15. Necrotizing Fasciitis of the Nose Complicated with Cavernous Sinus Thrombosis

    Directory of Open Access Journals (Sweden)

    D. Swaminath

    2014-01-01

    Full Text Available Necrotizing fasciitis is a rapidly progressive life threatening bacterial infection of the skin, the subcutaneous tissue, and the fascia. We present a case of necrotizing fasciitis involving the nose complicated by cavernous sinus thrombosis. Few cases of septic cavernous sinus thrombosis have been reported to be caused by cellulitis of the face but necrotizing fasciitis of the nose is rare. It is very important to recognize the early signs of cavernous thrombosis. Treatment for septic cavernous sinus thrombosis is controversial but early use of empirical antibiotics is imperative.

  16. Cavernous Angioma in the Falx Cerebri: A Case Report

    Science.gov (United States)

    Kim, Jin-Sung; Yang, Seung-Ho; Kim, Moon-Kyu

    2006-01-01

    Intracranial cavernous angiomas are benign vascular malformations and can be divided into intra-axial and extra-axial lesions. Extra-axial cavernous angiomas are relatively rare and usually arise in relation to the dura mater and mimick meningiomas. We report a case of cavernous angioma that occured in the falx cerebri of a 22-yr-old female patient with the special focus on neuroradiologic findings. This is the fourth case of cavernous angioma in the falx cerebri reported in the literature to our knowledge. PMID:17043437

  17. Cavernous sinus angioleiomyoma: case report and review of the literature.

    Science.gov (United States)

    Teranishi, Yu; Kohno, Michihiro; Sora, Shigeo; Sato, Hiroaki; Yokoyama, Munehiro

    2014-08-01

    Cavernous sinus angioleiomyoma (ALM) is extremely rare. Only three cases have been reported to be cavernous sinus ALM, and very few reports described characteristic findings for intracranial ALMs in detail. We report a new case of cavernous sinus ALM, with detailed information on the clinical presentation, radiology, pathology, and surgical approach. A 52-year-old woman had a 6-month history of right eye discomfort. Magnetic resonance imaging showed a right cavernous sinus tumor with heterogenous blush enhancement. Enhanced computed tomography scans and angiography showed small nodular enhancement in the tumor. Complete tumor resection was achieved via an extradural temporopolar approach. ALM was identified based on histologic examination. Intracranial ALMs are different from the ALMs that occur in the extremities based on our review of the literature. Intracranial ALMs appear more frequently in men than women. The cavernous type was the most common pathologically, and they occur often in the epiperidural location. Because cavernous sinus ALM occurs in the interdural space, an epidural approach should be selected. Therefore, it is important to include cavernous sinus ALM into a differential diagnosis of a cavernous sinus tumor. The blush enhancement and nodular enhancement within this lesion may be useful to distinguish cavernous sinus ALM from other differential diagnoses.

  18. Initial design for an experimental investigation of strongly coupled plasma behavior in the ATLAS facility

    CERN Document Server

    Munson, C P; Taylor, A J; Trainor, R J; Wood, B P; Wysocki, F J

    1999-01-01

    Summary form only given. Atlas is a high current (~30 MA peak, with a current risetime ~4.5 mu sec), high energy (E/sub stored/=24 MJ, E /sub load/=3-6 MJ), pulsed power facility which is being constructed at Los Alamos National Laboratory with a scheduled completion date in the year 2000. When operational, this facility will provide a platform for experiments in high pressure shocks (>20 Mbar), adiabatic compression ( rho / rho /sub 0/>5, P>10 Mbar), high magnetic fields (~2000 T), high strain and strain rates ( epsilon >200, d epsilon /dt~10/sup 4/ to 10/sup 6/ s/sup -1/), hydrodynamic instabilities of materials in turbulent regimes, magnetized target fusion, equation of state, and strongly coupled plasmas. For the strongly coupled plasma experiments, an auxiliary capacitor bank will be used to generate a moderate density (<0.1 solid), relatively cold (~1 eV) plasma by ohmic heating of a conducting material of interest such as titanium. This target plasma will be compressed against a central column conta...

  19. Dural cavernous hemangioma of the cerebellar falx.

    Science.gov (United States)

    Ito, Masaki; Kamiyama, Hiroyasu; Nakamura, Takatoshi; Nakajima, Hideki; Tokugawa, Joji

    2009-09-01

    A 47-year-old man presented with a rare case of dural cavernous hemangioma of the cerebellar falx incidentally detected as a mass lesion in the posterior cranial fossa. Neurological examination revealed no deficits or physical symptoms. Computed tomography demonstrated a well-demarcated hyperdense mass, with no calcification, in the cerebellar vallecula. Magnetic resonance imaging showed the extra-axial mass as homogeneously isointense on T(1)-weighted images, and hyperintense on T(2)-weighted images, compared to the adjacent cerebellar parenchyma that had no hypointense halo. The cerebellar vermis was slightly compressed ventrally, the adjacent brain parenchyma was not swollen, and there was no evidence of hydrocephalus. The mass and the attached cerebellar falx were homogeneously enhanced by contrast medium. The dural enhancement was considered a dural tail. No other intracranial vascular malformations were found. The preoperative diagnosis was posterior cranial fossa meningioma attached to the cerebellar falx. Median suboccipital craniotomy exposed the reddish mass attached to the cerebellar falx. The arachnoid plane was well preserved. Total en bloc resection was performed with minimal blood loss. The postoperative course was unremarkable. The resected mass had a reddish-brown mulberry appearance, with spongy cross section with multiple blood-filled spaces. Histological examination identified dilated blood-containing channels lined with flattened endothelium and separated by fibrous tissue, but no luminal thrombus or hemorrhage. The histological diagnosis was dural cavernous hemangioma of the cerebellar falx. Preoperative radiosurgery or embolization is recommended for most of the dural cavernous hemangiomas, but surgery for the present dural cavernous hemangioma of the cerebellar falx was performed safely.

  20. [Endovascular management of cavernous sinus dural fistulas].

    Science.gov (United States)

    Zenteno, Marco; Santos Franco, Jorge; Moscote-Salazar, Luis Rafael; Lee, Angel

    2014-01-01

    Describe the outcomes of patients diagnosed with indirect carotid-cavernous fistula treated by endovascular methods. A retrospective case series. Twelve patients with dural cavernous sinus fistula with important ophthalmologic involvement admitted and treated at the National Institute of Neurology and Neurosurgery between February 1990 and January 2005. Patients were managed by endovascular embolization for all fistulas. Angiographic controls to 24 hours and at 6 and 12 months were performed. 67 % were female and 33 % male. The mean age was 44 years. 67 % were spontaneous and 33% of traumatic origin. All patients had eye involvement with proptosis (92%) and involvement of the oculomotor nerve (67%). Headache and pulsatile tinnitus were not frequent ophthalmologic data. All were diagnosed by cerebral angiography, 33 % were type C, type D 67 %, and none of the type B classification Barrow. In 17 % of cases the distal arterial robbery showed severe. Predominance of anterior and superior venous drainage in 83 % and 42 % of cases occurred respectively. The surgical approach was arterial in 84% of cases, while in 17 % venous through the superior ophthalmic vein. Cyanoacrylate embolization material was used in 58 % of the cases, as it was associated with the use of removable ball with polyvinyl alcohol particles in 16 % in of venous approach cases. 17% detachable coils were utilized. There were no complications. After angiographic controls at 24 hours 100% occlusion was seen in patients treated with cyanoacrylate (58%) (p = 0.03). The remaining 42% were prescribed maneuver of manual compression. At 12-months angiography all patients had 100% occlusion of the carotid-cavernous fistula. CONCLSUIONS: This is the world's second largest series with indirect carotid-cavernous fistulas treated after trauma. 100 % of cases were cured with the use of a transarterial-controlled approach and N-butyl-cyanoacrylate after long-term observation.

  1. Cavernous angioma associated with ipsilateral hippocampal sclerosis

    Energy Technology Data Exchange (ETDEWEB)

    Okujava, M. [Institute of Radiology and Interventional Diagnostics, Tbilisi (Georgia); Ebner, A.; Schmitt, J.; Woermann, F.G. [Bethel Epilepsy Centre, Mara Hospital, Bielefeld (Germany)

    2002-07-01

    We report two cases with extratemporal cavernous angioma (CA) and coexisting ipsilateral hippocampal sclerosis. Classically dual pathology is defined as the association of hippocampal sclerosis with an extrahippocampal lesion. Subtle changes in hippocampus might be overlooked in the presence of an unequivocal extrahippocampal abnormality. Seizure outcome after epilepsy surgery in cases with dual pathology is less favourable if only one of the lesions is removed. Dual pathology must always be considered in diagnostic imaging of patients with intractable epilepsy and CA. (orig.)

  2. Cardiac Cavernous Hemangioma Coexisting With Pulmonary Cavernous Hemangiomas and Giant Hepatic Hemangioma.

    Science.gov (United States)

    Wang, Chunping; Chen, Hao; Sun, Lin; Mei, Yunqing

    2017-02-01

    We describe a case of cardiac cavernous hemangioma with coexisting pulmonary cavernous hemangiomas and hepatic hemangioma. A 35-year-old woman who had previously received a living donor liver transplant to cure giant hepatic hemangioma was seen because of chest pain. A cardiac neoplasm and multiple pulmonary nodules were detected. The tumor was surgically removed, and biopsy specimens were taken from the lung nodules. Histopathologic examination confirmed that both lesions were cavernous hemangiomas. The patient was discharged without adverse events postoperatively. Cardiac hemangioma is an extremely rare entity; the present case is unique for its multiorgan involvement. Suspicion of this entity should be aroused if the imaging manifestation suggests a vascular nature. Copyright © 2017 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  3. MR imaging features that distinguish spinal cavernous angioma from hemorrhagic ependymoma and serial MRI changes in cavernous angioma.

    Science.gov (United States)

    Jeon, Inhwan; Jung, Woo Sang; Suh, Sang Hyun; Chung, Tae-Sub; Cho, Yong-Eun; Ahn, Sung Jun

    2016-10-01

    Cavernous angiomas of the spinal cord exhibit imaging characteristics that may overlap with those of hemorrhagic ependymoma. In the present study, we aimed to identify specific magnetic resonance imaging (MRI) findings that could be used to differentiate cavernous angioma from hemorrhagic ependymoma, and to evaluate serial MRI changes in cases of cavernous angioma. We retrospectively evaluated MR images of spinal cord tumors collected at our hospital from 2007 to 2015. From this cohort of images, 11 pathologically confirmed cavernous angiomas and 14 pathologically confirmed hemorrhagic ependymomas were compared with respect to the size of the tumor, longitudinal location, axial location, enhancement pattern, syrinx, edema, tumor margin, signal intensity of T2WI, signal intensity of T1WI, and longitudinal spreading of the hemorrhage. Serial MR images of seven spinal cavernous angiomas were reviewed. Small size, eccentric axial location, minimal enhancement, and absence of edema were more frequently observed on images of cavernous angioma compared to those of hemorrhagic ependymoma (p cavernous angioma included increased longitudinal spreading of the hemorrhage (6/7, 86 %) and emergence of high signal intensity on T1WI (1/7, 14 %). Small size, eccentric axial location, minimal enhancement, and absence of edema are significant MRI findings that may be used to distinguish Type I and Type II spinal cavernous angiomas from hemorrhagic ependymomas. Furthermore, longitudinal spreading of the hemorrhage may be observed on follow-up MRIs of cavernous angiomas.

  4. 25th January 2011-Chief Scientist-Ministry of Industry,Trade and Labor-Mr Avi Hasson-Israel visiting the ATLAS Experiment at CERN

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    Photo 1-13:The delegation visiting ATLAS cavern with ATLAS Former Spokesperson Dr P. Jenni Photo 14:P. Jenni+ATLAS Collaboration Weizmann Institute of Sciences Israeli Industrial Liaison Office (ILO) Prof. Giora Mikenberg+Mr A. Hasson+Adviser for Israel Dr John Ellis+Commercial Attaché to Switzerland and Deputy Permanent Representative to the WTO Permanent Mission of Israel Mr Shai Moses Photo 15-22:Signature of the Guest Book with J. Ellis

  5. Cerebral cavernous malformations associated with cutaneous angiokeratomas and hemangiomas.

    Science.gov (United States)

    Whitworth, Walter W; Hick, Ryan W; Nelson, Kelly C; Sidhu-Malik, Navjeet K

    2015-11-01

    We report the case of a 66-year-old man with adult-onset seizures and multiple cerebral cavernous malformations who developed numerous eruptive cutaneous angiokeratomas on the legs, scrotum, abdomen, and back as well as lobular and cavernous hemangiomas on the arms. Genetic analysis demonstrated a mutation in the KRIT1, ankyrin repeat containing gene (also known as CCM1).

  6. 36 CFR 7.47 - Carlsbad Caverns National Park.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Carlsbad Caverns National Park. 7.47 Section 7.47 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.47 Carlsbad Caverns National Park. (a...

  7. Calcified cavernous hemangioma of the ovary: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yeon Hee [Dankook Univ. College of Medicine, Seoul (Korea, Republic of)

    2000-12-01

    Ovarian hemangiomas are very uncommon and most are of the cavernous type. A few reports have described the radiologic findings of this neoplasm, but as far as the author is aware, the literature contains no description of calcified cavernous hemangioma. A case in which this condition involved the ovary is now reported.

  8. Anatomy of the sympathetic pathways in the cavernous sinus

    NARCIS (Netherlands)

    van Overbeeke, J. J.; Dujovny, M.; Troost, D.

    1995-01-01

    We studied sympathetic fibres in the cavernous sinus in 40 unfixed specimens obtained from human cadavers. Sympathetic fibres in the cavernous sinus are understood to be grouped in a plexiform configuration surrounding the internal carotid artery and have a diffuse distribution among the sympathetic

  9. Cavernous Lymphangioma of the Lower Lip- A Rare Case Report ...

    African Journals Online (AJOL)

    Lymphangioma are rare, benign, and hamartomatous tumors of the lymphatic vessels, that show a marked predilection for the head and neck region. Very few cases of Cavernous lymphangioma have been reported to occur in the lower lip. We report a rare case of Cavernous Lymphangioma of the lower lip in a 13 years old ...

  10. Recovery of opthalmoplegia associated with cavernous sinus dural arteriovenous fistulas after transvenous cavernous sinus packing

    Energy Technology Data Exchange (ETDEWEB)

    Lv Xianli; Jiang Chuhan; Li Youxiang; Yang Xinjian [Beijing Neurosurgical institute, Beijing Tiantan Hospital, Capital Medical University, 6, Tiantan Xili, Chongwen, Beijing (China); Wu Zhongxue, E-mail: ttyyzjb@sina.co [Beijing Neurosurgical institute, Beijing Tiantan Hospital, Capital Medical University, 6, Tiantan Xili, Chongwen, Beijing (China)

    2010-08-15

    Background: We report the recovery of ophthalmoplegia in 11 patients with cavernous sinus dural arteriovenous fistula (CSDAVF) after sinus packing at follow-up. Methods: Of 18 patients with CSDAVF treated with transvenous cavernous sinus packing between August 2002 and December 2007 at Beijing Tiantan Hospital, there were 9 patients with initial CNIII or CNVI dysfunction and 2 patients with CNVI dysfunction immediately after cavernous sinus packing selected and reevaluated. Results: Of 11 patients with CNIII or CNVI palsy, recovery was complete in 10. In 1 patient, complete CNVI palsy was unchanged because the CSDAVF was not cured. There were 6 men and 5 women with a mean age of 52.9 years. In 5 patients, CNVI palsy was associated with chemosis, proptosis and pulsatile tinnitus. Timing of treatment after onset of symptoms was from 4 to 35 days in 9 patients. All CSDAVFs were Barrow type D. Mean follow-up after treatment was 17.7 months (range, 2-54 months). Conclusion: CSDAVF-induced CNIII or CNVI palsies can be cured after cavernous sinus packing transvenously in most patients.

  11. Simulation of `cavern' formation in the mixing of viscoplastic fluids

    Science.gov (United States)

    Mirpuri, Karan; Kahouadji, Lyes; Chergui, Jalel; Juric, Damir; Shin, Seungwon; Piccione, Patrick; Matar, Omar K.

    2017-11-01

    This work focuses on elucidating the effects of impeller size and speed on `cavern' formation in Herschel-Bulkley fluids using CFD simulations. `Caverns' are defined as the well-mixed regions within the fluid usually encasing the impeller where shear stress imparted by the impeller overcomes the material yield stress. The caverns are often surrounded by zones of stagnant fluid isolated from bulk flow, wherein mass transfer is mainly restricted to diffusion, making them adverse to mixing quality. Numerous models have been developed to predict cavern size including the spherical, cylindrical and toroidal models. Due to its prevalence as a means of comparison in modern experiments, the Elson et al. experiment is replicated for a number of rotational speeds (4, 8 and 12 Hz) and three geometrically-similar Rushton turbines using the code Blue which facilitates the `measurement' of cavern size and depth among other parameters. Funding from Syngenta gratefully acknowledged.

  12. Tentorial cavernous angioma with profuse bleeding. Case report.

    Science.gov (United States)

    Mori, Hiroshi; Koike, Toshiro; Endo, Shin; Takii, Yoshitaka; Uzuka, Takeo; Takahashi, Hitoshi; Ito, Jusuke; Tanaka, Ryuichi

    2009-01-01

    This 15-year-old boy with a tentorial cavernous angioma reported occasional headache and scintillation in his left visual field. Magnetic resonance imaging revealed a well-demarcated, homogeneously enhanced tumor originating from the right cerebellar tentorium and extending into both the supratentorial and infratentorial spaces. Although a meningioma was suspected, vertebral artery angiography revealed a thickened meningeal branch originating from the right posterior inferior cerebellar artery and flecked tumor stain with pooling of contrast medium until the late venous phase. A cavernous angioma of the tentorium was suspected based on this finding, and as expected from the radiological findings, profuse bleeding was encountered during tumor removal. The histological diagnosis was a cavernous angioma. A cavernous angioma of the tentorium is extremely rare but should be differentiated from a meningioma preoperatively given that a cavernous angioma of dural origin tends to bleed massively during removal.

  13. Endovascular treatment of carotid cavernous sinus fistula: A systematic review

    Science.gov (United States)

    Korkmazer, Bora; Kocak, Burak; Tureci, Ercan; Islak, Civan; Kocer, Naci; Kizilkilic, Osman

    2013-01-01

    Carotid cavernous sinus fistulas are abnormal communications between the carotid system and the cavernous sinus. Several classification schemes have described carotid cavernous sinus fistulas according to etiology, hemodynamic features, or the angiographic arterial architecture. Increased pressure within the cavernous sinus appears to be the main factor in pathophysiology. The clinical features are related to size, exact location, and duration of the fistula, adequacy and route of venous drainage and the presence of arterial/venous collaterals. Noninvasive imaging (computed tomography, magnetic resonance, computed tomography angiography, magnetic resonance angiography, Doppler) is often used in the initial work-up of a possible carotid cavernous sinus fistulas. Cerebral angiography is the gold standard for the definitive diagnosis, classification, and planning of treatment for these lesions. The endovascular approach has evolved as the mainstay therapy for definitive treatment in situations including clinical emergencies. Conservative treatment, surgery and radiosurgery constitute other management options for these lesions. PMID:23671750

  14. Clean tracks for ATLAS

    CERN Multimedia

    2006-01-01

    First cosmic ray tracks in the integrated ATLAS barrel SCT and TRT tracking detectors. A snap-shot of a cosmic ray event seen in the different layers of both the SCT and TRT detectors. The ATLAS Inner Detector Integration Team celebrated a major success recently, when clean tracks of cosmic rays were detected in the completed semiconductor tracker (SCT) and transition radiation tracker (TRT) barrels. These tracking tests come just months after the successful insertion of the SCT into the TRT (See Bulletin 09/2006). The cosmic ray test is important for the experiment because, after 15 years of hard work, it is the last test performed on the fully assembled barrel before lowering it into the ATLAS cavern. The two trackers work together to provide millions of channels so that particles' tracks can be identified and measured with great accuracy. According to the team, the preliminary results were very encouraging. After first checks of noise levels in the final detectors, a critical goal was to study their re...

  15. Optical coherence tomography of the rat cavernous nerves

    Science.gov (United States)

    Fried, Nathaniel M.; Rais-Bahrami, Soroush; Lagoda, Gwen A.; Chuang, Ying; Burnett, Arthur L.; Su, Li-Ming

    2007-02-01

    Improvements in identification, imaging, and visualization of the cavernous nerves during radical prostatectomy, which are responsible for erectile function, may improve nerve preservation and postoperative potency. Optical coherence tomography (OCT) is capable of real-time, high-resolution, cross-sectional, in vivo tissue imaging. The rat prostate serves as an excellent model for studying the use of OCT for imaging the cavernous nerves, as the rat cavernous nerve is a large, visible, and distinct bundle allowing for easy identification with OCT in addition to histologic confirmation. Imaging was performed with the Niris OCT system and a handheld 8 Fr probe, capable of acquiring real-time images with 11-μm axial and 25-μm lateral resolution in tissue. Open surgical exposure of the prostate was performed on a total of 6 male rats, and OCT images of the prostate, cavernous nerve, pelvic plexus ganglion, seminal vesicle, blood vessels, and periprostatic fat were acquired. Cavernous nerve electrical stimulation with simultaneous intracorporeal pressure measurements was performed to confirm proper identification of the cavernous nerves. The prostate and cavernous nerves were also processed for histologic analysis and further confirmation. Cross-sectional and longitudinal OCT images of the cavernous nerves were acquired and compared with histologic sections. The cavernous nerve and ganglion could be differentiated from the surrounding prostate gland, seminal vesicle, blood vessels, bladder, and fatty tissue. We report preliminary results of OCT images of the rat cavernous nerves with histologic correlation and erectile stimulation measurements, thus providing interpretation of prostate structures as they appear in OCT images.

  16. ATLAS : civil engineering at Point 1

    CERN Multimedia

    2002-01-01

    The ATLAS experimental area is located in Point 1, just across the main CERN entrance, in the commune of Meyrin. There people are ever so busy to finish the different infrastructures for ATLAS. Real underground video.

  17. ATLAS: civil engineering Point 1

    CERN Multimedia

    Jean-Claude Vialis

    1998-01-01

    Different phases of the SX 15 realisation to Point 1 : zone of the ATLAS experiment 00:13:43 Realization of the concrete floor 19-10-1998 00:29:26 Putting up the metal rails for the roof 19-10-1998 00:33:42 Road alignment entering to POINT1 and in Bollot wood 27-10-1998 00:41:53 General sight of the buildings in construction Building SX gives the cover for the work at the experiment It is used to shelter the Pit and the work for the underground cavern as well as for covering the ground work with big cranes that allows the lowering of the components belonging to the detector. The hall is also used as a detector part storage and cover during the assembly. It shelters small workshops of mechanics and electronics necessary for the assembly and the maintenance of the ATLAS experiment.

  18. Meningioma and cavernous angioma following childhood radiotherapy

    Directory of Open Access Journals (Sweden)

    Baheti Akshay

    2010-01-01

    Full Text Available Prophylactic cranial irradiation has been a part of multimodality management of acute lymphoblastic leukemia (ALL. With optimum treatment and the resultant long-term cure rates, long-term side effects of radiation including radiation-induced neoplasms have been increasingly unearthed. We report a rare case of development of both a meningioma and a cavernous angioma following prophylactic cranial irradiation as a part of treatment of ALL. Regular follow-up and high index of suspicion for late radiation sequelae after treatment are therefore justifiable in leukemia survivors with history of prophylactic cranial irradiation.

  19. Benign Mass in Tonsil- Cavernous Hemangioma

    Science.gov (United States)

    Joseph, Sumitha; Prakash, M.; Mohammed, Hafida K; Govar, Aberna

    2013-01-01

    Cavernous hemangioma is also called as ‘ANGIOMA CAVERNOSUM’ or ‘CAVERNOMA’ as benign lesion of blood vessels. They are similar to strawberry hemangioma but deeply situated. Although most often associated with skin it is also sometimes found in mucous membrane, brain and the viscera. The diagnosis of hemangiomas is mainly based on clinical evaluation . Isolated hemangiomas in the tonsillar tissue is a rare occurance. In this we report had a case of adult tonsillar hemangioma of left side associated with recurrent tonsillitis . He was effectively managed surgically without any complications. PMID:24298502

  20. Cavernous lymphangioma arising from uterine corpus.

    Science.gov (United States)

    Furui, Tatsuro; Imai, Atsushi; Yokoyama, Yasuhiro; Sato, Eriko; Tamaya, Teruhiko

    2003-07-01

    A rare case of giant uterine lymphangioma was experienced. A 44-year-old female noted a rapidly grown abdominal tumor and its accompanied symptoms, progressive abdominal distension, lumbago, and developed leg edema. Ultrasonography made a possible diagnosis of a huge ovarian tumor; postoperative diagnosis was cavernous lymphangioma arising from the uterus. According to the literature, lymphangioma itself is a rare tumor, and giant lymphangioma arising from uterine corpus is extremely rare. We experienced an extremely rare case of uterine lymphangioma and ultrasound tomography better imaged the tumor inside.

  1. CD105 expression in oral capillary hemangiomas and cavernous hemangiomas.

    Science.gov (United States)

    Matsumoto, Naoyuki; Tsuchiya, Motomi; Nomoto, Shouta; Matsue, Yasuyoshi; Nishikawa, Yohichi; Takamura, Tsuyoshi; Oki, Hidero; Komiyama, Kazuo

    2015-03-01

    Capillary hemangioma (capillary lobular hemangioma) and cavernous hemangioma (venous malformation) are relatively common oral tumors/malformations and are characterized by increased numbers of normal and abnormal blood vessels. However, the causes of these lesions are not well understood. CD105 (endoglin) is predominantly expressed in proliferating blood endothelial cells (ECs). We analyzed expressions of CD105, CD34, von Willebrand factor, Ki-67, cyclooxygenase-2 (COX-2), and vascular endothelial growth factor (VEGF)-A in 31 capillary hemangiomas and 34 cavernous hemangiomas. Staining scores were calculated as the product of the proportion score and intensity score. Morphologically normal oral mucosa specimens (n = 10) were simultaneously evaluated as normal controls. As compared with cavernous hemangiomas and normal controls, capillary hemangiomas had higher staining scores for CD105, VEGF-A, and COX-2. The Ki-67 labeling index was significantly higher in capillary hemangiomas than in cavernous hemangiomas and normal controls (P characteristics of capillary and cavernous hemangiomas are quite different. The ECs of capillary hemangiomas actively proliferated and were generally regulated by VEGF-A. In contrast, the ECs of cavernous hemangiomas lacked proliferative activity. These results suggest that angiogenesis and vasodilatation of pre-existing blood vessels are important in the development of capillary hemangioma and cavernous hemangioma, respectively.

  2. Quantitative Susceptibility Mapping in Cerebral Cavernous Malformations: Clinical Correlations.

    Science.gov (United States)

    Tan, H; Zhang, L; Mikati, A G; Girard, R; Khanna, O; Fam, M D; Liu, T; Wang, Y; Edelman, R R; Christoforidis, G; Awad, I A

    2016-07-01

    Quantitative susceptibility mapping has been shown to assess iron content in cerebral cavernous malformations. In this study, our aim was to correlate lesional iron deposition assessed by quantitative susceptibility mapping with clinical and disease features in patients with cerebral cavernous malformations. Patients underwent routine clinical scans in addition to quantitative susceptibility mapping on 3T systems. Data from 105 patients met the inclusion criteria. Cerebral cavernous malformation lesions identified on susceptibility maps were cross-verified by T2-weighted images and differentiated on the basis of prior overt hemorrhage. Mean susceptibility per cerebral cavernous malformation lesion (χ̄lesion) was measured to correlate with lesion volume, age at scanning, and hemorrhagic history. Temporal rates of change in χ̄lesion were evaluated in 33 patients. Average χ̄lesion per patient was positively correlated with patient age at scanning (P cavernous malformation lesions with prior overt hemorrhages exhibited higher χ̄lesion than those without (P cavernous malformation lesions, higher mean quantitative susceptibility mapping signal in hemorrhagic lesions, and minimum longitudinal quantitative susceptibility mapping signal change in clinically stable lesions. Quantitative susceptibility mapping has the potential to be a novel imaging biomarker supplementing conventional imaging in cerebral cavernous malformations. The clinical significance of such measures merits further study. © 2016 by American Journal of Neuroradiology.

  3. 6 June 2008 - Chancellor F. Tomàs Vert, University of Valencia, visiting ATLAS control room and experimental area with Collaboration Spokesperson P. Jenni.

    CERN Multimedia

    Mona Schweizer

    2008-01-01

    6 June 2008 - Chancellor F. Tomàs Vert, University of Valencia, visiting ATLAS control room and experimental area with Collaboration Spokesperson P. Jenni. Other participants: Prof. Francisco José Botella, Director, Instituto de Fisica Corpuscular, University of València and CSIC Prof. José Peñarrocha, Dean, Faculty of Physics Prof. Antonio Ferrer, Instituto de Fisica Corpuscular, University of València and CSIC Prof. Antonio Pich, University of València, Member of IFIC (CSIC - Univ. València), Coordinator of CPAN, Spanish National Centre for Particle, Astroparticle and Nuclear Physics.

  4. Beta adrenergic receptors in human cavernous tissue

    Energy Technology Data Exchange (ETDEWEB)

    Dhabuwala, C.B.; Ramakrishna, C.V.; Anderson, G.F.

    1985-04-01

    Beta adrenergic receptor binding was performed with /sup 125/I iodocyanopindolol on human cavernous tissue membrane fractions from normal tissue and transsexual procedures obtained postoperatively, as well as from postmortem sources. Isotherm binding studies on normal fresh tissues indicated that the receptor density was 9.1 fmoles/mg. with a KD of 23 pM. Tissue stored at room temperature for 4 to 6 hours, then at 4C in saline solution for 19 to 20 hours before freezing showed no significant changes in receptor density or affinity, and provided evidence for the stability of postmortem tissue obtained within the same time period. Beta receptor density of 2 cavernous preparations from transsexual procedures was not significantly different from normal control tissues, and showed that high concentrations of estrogen received by these patients had no effect on beta adrenergic receptor density. Displacement of /sup 125/iodocyanopindolol by 5 beta adrenergic agents demonstrated that 1-propranolol had the greatest affinity followed by ICI 118,551, zinterol, metoprolol and practolol. When the results of these displacement studies were subjected to Scatfit, non- linear regression line analysis, a single binding site was described. Based on the relative potency of the selective beta adrenergic agents it appears that these receptors were of the beta 2 subtype.

  5. Molecular diagnosis in cerebral cavernous malformations.

    Science.gov (United States)

    Mondejar, R; Lucas, M

    2017-10-01

    Cerebral cavernous malformations (CCMs; OMIM 116860) are enlarged vascular cavities without intervening brain parenchyma whose estimated prevalence in the general population is between 0.1% and 0.5%. Familial CCM is an autosomal dominant disease with incomplete clinical and radiological penetrance. Three genes have been linked to development of the lesions: CCM1/KRIT1, CCM2/MGC4607, and CCM3/PDCD10. The aetiological mutation is not detected in a large percentage of cases and new approaches are therefore needed. The aim of this review is to analyse current molecular techniques and the possible mutations or variations which can be detected in a molecular genetics or molecular biology laboratory. Likewise, we will analyse other alternatives that may help detect mutations in those patients showing negative results. A molecular diagnosis of cerebral cavernous malformations should provide at least the copy number variation and sequencing of CCM genes. In addition, appropriate genetic counselling is a crucial source of information and support for patients and their relatives. Copyright © 2015 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

  6. A tough truck for ATLAS

    CERN Multimedia

    2003-01-01

    One of the mobile support structures that will be used to manoeuvre and assemble components of the ATLAS detector in its cavern was put through its paces at the end of July and passed its load tests with flying colours. The tests, which involved the surveyors taking measurements to detect any load-induced mechanical deformations, were carried out in Building 191. "The "truck" has been subjected to static tests with loads of up to 1250 tonnes and can carry and transport on air cushions a nominal load of up to 1000 tonnes at a top speed of 30 cm per minute," explains project leader Tommi Nyman. "It took two weeks to assemble the truck's components, the last of which arrived at CERN on 24 June. It then took a further 20 days to load the truck up for the test." The 8.5 metre-high truck will be used for final assembly of some of the ATLAS components, including the calorimeters, in cavern UX15. This powerful device is the result of a collaboration between CERN and the Henryk Niewodniczanski Institute of Nuclear ...

  7. Strategic petroleum reserve caverns casing damage update 1997

    Energy Technology Data Exchange (ETDEWEB)

    Munson, D.E.; Molecke, M.A.; Neal, J.T. [and others

    1998-01-01

    Hanging casing strings are used for oil and brine transfer in the domal salt storage caverns of the Strategic Petroleum Reserve (SPR). Damage to these casings is of concern because hanging string replacement is costly and because of implications on cavern stability. Although the causes of casing damage are not always well defined, many events leading to damage are assumed to be the result of salt falls impacting the hanging strings. However, in some cases, operational aspects may be suspected. The history of damage to hanging strings is updated in this study to include the most recent events. Potential general domal and local operational and material factors that could influence the tendency for caverns to have salt falls are examined in detail. As a result of this examination, general factors, such as salt dome anomalies and crude type, and most of the operational factors, such as geometry, location and depressurizations, are not believed to be primary causes of casing damage. Further analysis is presented of the accumulation of insolubles during cavern solutioning and accumulation of salt fall material on the cavern floor. Inaccuracies in sump geometry probably make relative cavern insolubles contents uncertain. However, determination of the salt fall accumulations, which are more accurate, suggest that the caverns with the largest salt fall accumulations show the greatest number of hanging string events. There is good correlation between the accumulation rate and the number of events when the event numbers are corrected to an equivalent number for a single hanging string in a quiescent, operating cavern. The principal factor that determines the propensity for a cavern to exhibit this behavior is thought to be the effect of impurity content on the fracture behavior of salt.

  8. Protective effect of annexin-A1 against irreversible damage to cavernous tissue after cavernous nerve injury in the rat.

    Science.gov (United States)

    Facio, Fernando N; Burnett, Arthur L

    2012-11-01

    Study Type - Aetiology (case control) Level of Evidence 3b. What's known on the subject? and What does the study add? Penile rehabilitation is still controversial regarding good results. Our study shows a non-invasive treatment option to recovery after cavernous nervous damage. The assessment of changes in the intracavernous pressure and karyometry demonstrates the protective effect of annexin-A1 in an animal model of cavernous nerve injury. We found that annexin-A1 effectively preserved erectile function, evidently through significantly protecting the corpus cavernosum tissue against fibrosis. • To evaluate the protective effect of annexin-A1 against irreversible damage to cavernous tissue after cavernous nerve injury. • Thirty Sprague-Dawley male rats were divided into 3 groups; sham-operated rats (n= 10), bilateral cavernous nerve injury treated intravenously with 100 µg/kg annexin-A1 (n= 10), and a crush group of rats submitted to bilateral cavernous nerve injury and vehicle (n= 10). Groups were compared in respect to intracavernous pressure and karyometric parameters. • After annexin-A1 treatment, the maximum changes in intracavernous pressure responses were significantly higher in the annexin-A1 group compared to the vehicle-only group on the 7(th) postoperative day (p-value cavernous nerve injury. We found that annexin-A1 effectively preserved erectile function, evidently through significantly protecting the corpus cavernosum tissue against fibrosis. © 2012 BJU INTERNATIONAL.

  9. Geometrical versus rheological transient creep closure in a salt cavern

    Science.gov (United States)

    Bérest, Pierre; Karimi-Jafari, Mehdi; Brouard, Benoît

    2017-11-01

    An in-situ test performed in a brine-filled cavern proves that, when brine pressure decreases rapidly, the creep closure rate increases drastically. Conversely, a rapid pressure increase leads to ;reverse; creep closure: cavern volume increases, even when, at cavern depth, fluid pressure is lower than geostatic pressure. It is tempting to explain these two phenomena by transient salt creep, a characteristic feature of salt rheological behavior commonly observed during laboratory creep tests. In fact, computations performed on an idealized cylindrical cavern excavated from a Norton-Hoff rock mass (a constitutive law that includes no transient component) prove that these two phenomena are, at least partly, of a structural nature: their origin is in the slow redistribution of stresses following any pressure change.

  10. Cavernous sinus syndrome secondary to intracranial lymphoma in a cat.

    Science.gov (United States)

    Guevar, Julien; Gutierrez-Quintana, Rodrigo; Peplinski, George; Helm, Jenny R; Penderis, Jacques

    2014-06-01

    Cavernous sinus syndrome is characterised by internal and external ophthalmoplegia and sensory deficits over the head due to combined deficits of the three cranial nerves (CNs) responsible for the eye movements and pupil function (CN III, IV, VI) and at least one branch of the trigeminal nerve (CN V). It has rarely been described in cats and may occur secondarily to inflammatory, infectious or neoplastic lesions within the region of the cavernous sinus on the ventral aspect of the calvarium. This report describes the clinical and magnetic resonance imaging findings in a 14-year-old domestic shorthair cat with neurological deficits compatible with cavernous sinus syndrome caused by presumptive extranodal lymphoma. Treatment with chemotherapy resulted in clinical and imaging remission. Identification of the neurological deficits in cavernous sinus syndrome allows accurate neuroanatomical localisation in order to target diagnostic imaging studies. © ISFM and AAFP 2013.

  11. Therapeutic surprise! Photodynamic therapy for cavernous haemangioma of the disc

    Directory of Open Access Journals (Sweden)

    Mahesh P Shanmugam

    2017-01-01

    Full Text Available Purpose: To report the response of cavernous haemangioma of the disc to PDT. Methods and Patients: A 32 years old lady presented to us with complaints of sudden onset of blurry vision in her right eye. What seemed initially as polypoidal choroidal vasculopathy turned out as cavernous haemangioma of the disc after pneumatic displacement of the sub-retinal haeme. She was treated with PDT as she was prone to recurrent haemorrhage from the lesion due to her low platelet count. Results: Complete regression of the cavernous haemangioma was noted as early as the second week itself and remained regressed for 4 months. Conclusion: PDT can be safe option for patients presenting with symptomatic cavernous haemangioma of the disc or retina.

  12. Fibrosis of corpus cavernosum in animals following cavernous nerve ablation

    National Research Council Canada - National Science Library

    Hu, Wan-Li; Hu, Li-Quan; Song, Jian; Li, Shi-Wen; Zheng, Xin-Min; Cheng, Bei; Tian, Bing-Chun

    2004-01-01

    To investigate alterations of smooth muscle cells and collagen fibers in corpus cavernosum following cavernous neurectomy and its relation to the expression of transforming growth factor-beta1 (TGF-beta1...

  13. Therapeutic surprise! Photodynamic therapy for cavernous haemangioma of the disc.

    Science.gov (United States)

    Shanmugam, Mahesh P; Ramanjulu, Rajesh; Dwivedi, Shyamal; Barigali, Aditya; Havanje, Ajith

    2017-08-01

    To report the response of cavernous haemangioma of the disc to PDT. A 32 years old lady presented to us with complaints of sudden onset of blurry vision in her right eye. What seemed initially as polypoidal choroidal vasculopathy turned out as cavernous haemangioma of the disc after pneumatic displacement of the sub-retinal haeme. She was treated with PDT as she was prone to recurrent haemorrhage from the lesion due to her low platelet count. Complete regression of the cavernous haemangioma was noted as early as the second week itself and remained regressed for 4 months. PDT can be safe option for patients presenting with symptomatic cavernous haemangioma of the disc or retina.

  14. Lateral Transorbital Neuroendoscopic Approach to the Lateral Cavernous Sinus

    Science.gov (United States)

    Bly, Randall A.; Ramakrishna, Rohan; Ferreira, Manuel; Moe, Kris S.

    2013-01-01

    Objective To design and assess the quality of a novel lateral retrocanthal endoscopic approach to the lateral cavernous sinus. Design Computer modeling software was used to optimize the geometry of the surgical pathway, which was confirmed on cadaver specimens. We calculated trajectories and surgically accessible areas to the middle fossa while applying a constraint on the amount of soft tissue retraction. Setting Virtual computer model to simulate the surgical approach and cadaver laboratory. Participants The authors. Main Outcome Measures Adequate surgical access to the lateral cavernous sinus and adjacent regions as determined by operations on the cadaver specimens. Additionally, geometric limitations were imposed as determined by the model so that retraction on soft tissue structures was maintained at a clinically safe distance. Results Our calculations revealed adequate access to the lateral cavernous sinus, Meckel cave, orbital apex, and middle fossa floor. Cadaveric testing revealed sufficient access to these areas using cavernous sinus. PMID:24498584

  15. Natural history of cerebral cavernous malformations.

    Science.gov (United States)

    Ene, Chibawanye; Kaul, Anand; Kim, Louis

    2017-01-01

    Cerebral cavernous malformations (CCM) are vascular abnormalities of the central nervous system with an incidence of 0.4-0.5% and an annual rate of hemorrhage ranging from 0.7% to 1%. Most lesions are located in the cerebral hemisphere but some occur in deeper locations such as the basal ganglia and pons. The most common symptoms during presentation are headache, seizures, and focal neurologic deficits. Surgery remains the most effective treatment modality for symptomatic CCM, while the management of incidental CCM remains controversial. Factors associated with increased risk of hemorrhage include being female and less than 40 years old. This finding, however, is not consistent in all natural history studies evaluated. During follow-up, the most important and consistent risk factor for rebleed was a prior hemorrhage. Here, we provide an indepth but concise review of the literature regarding the natural history of CCMs. © 2017 Elsevier B.V. All rights reserved.

  16. Cerebral cavernous malformation proteins at a glance

    Science.gov (United States)

    Draheim, Kyle M.; Fisher, Oriana S.; Boggon, Titus J.; Calderwood, David A.

    2014-01-01

    ABSTRACT Loss-of-function mutations in genes encoding KRIT1 (also known as CCM1), CCM2 (also known as OSM and malcavernin) or PDCD10 (also known as CCM3) cause cerebral cavernous malformations (CCMs). These abnormalities are characterized by dilated leaky blood vessels, especially in the neurovasculature, that result in increased risk of stroke, focal neurological defects and seizures. The three CCM proteins can exist in a trimeric complex, and each of these essential multi-domain adaptor proteins also interacts with a range of signaling, cytoskeletal and adaptor proteins, presumably accounting for their roles in a range of basic cellular processes including cell adhesion, migration, polarity and apoptosis. In this Cell Science at a Glance article and the accompanying poster, we provide an overview of current models of CCM protein function focusing on how known protein–protein interactions might contribute to cellular phenotypes and highlighting gaps in our current understanding. PMID:24481819

  17. Interactive evolution concept for analyzing a rock salt cavern under cyclic thermo-mechanical loading

    Science.gov (United States)

    König, Diethard; Mahmoudi, Elham; Khaledi, Kavan; von Blumenthal, Achim; Schanz, Tom

    2016-04-01

    The excess electricity produced by renewable energy sources available during off-peak periods of consumption can be used e.g. to produce and compress hydrogen or to compress air. Afterwards the pressurized gas is stored in the rock salt cavities. During this process, thermo-mechanical cyclic loading is applied to the rock salt surrounding the cavern. Compared to the operation of conventional storage caverns in rock salt the frequencies of filling and discharging cycles and therefore the thermo-mechanical loading cycles are much higher, e.g. daily or weekly compared to seasonally or yearly. The stress strain behavior of rock salt as well as the deformation behavior and the stability of caverns in rock salt under such loading conditions are unknown. To overcome this, existing experimental studies have to be supplemented by exploring the behavior of rock salt under combined thermo-mechanical cyclic loading. Existing constitutive relations have to be extended to cover degradation of rock salt under thermo-mechanical cyclic loading. At least the complex system of a cavern in rock salt under these loading conditions has to be analyzed by numerical modeling taking into account the uncertainties due to limited access in large depth to investigate material composition and properties. An interactive evolution concept is presented to link the different components of such a study - experimental modeling, constitutive modeling and numerical modeling. A triaxial experimental setup is designed to characterize the cyclic thermo-mechanical behavior of rock salt. The imposed boundary conditions in the experimental setup are assumed to be similar to the stress state obtained from a full-scale numerical simulation. The computational model relies primarily on the governing constitutive model for predicting the behavior of rock salt cavity. Hence, a sophisticated elasto-viscoplastic creep constitutive model is developed to take into account the dilatancy and damage progress, as well as

  18. ATLAS Civil Engineering Point 1

    CERN Multimedia

    Jean-Claude Vialis

    2000-01-01

    Different phases of realisation to Point 1 : zone of the ATLAS experiment The ATLAS experimental area is located in Point 1, just across the main CERN entrance, in the commune of Meyrin. There people are ever so busy to finish the different infrastructures for ATLAS. Real underground video. When passing throw the walls the succeeding can be heard and seen. The film has original working sound.

  19. Borehole and cavern radar for geological and geotechnical exploration in salt cavern construction; Das Bohrloch- und Kavernenradar zur geologischen und geotechnischen Erkundung im Salzkavernenbau

    Energy Technology Data Exchange (ETDEWEB)

    Petrat, L.; Siever, K. [Deutsche Montan Technologie GmbH, Essen (Germany); Gaulke, K. [NWKG, Nord-West Kavernengesellschaft, Wilhelmshaven (Germany); Kleinefeld, B. [DEEP. Underground und Engineering GmbH, Bad Zwischenahn (Germany); Behlau, J. [Bundesanstalt fuer Geowissenschaften und Rohstoffe, Hannover (Germany)

    2005-08-01

    The DMT borehole and cavern radar system is used in the Ruestringen cavern field near Wilhelmshaven by Nord-West Kavernengesellschaft mbH (NWKG). The radar measurements provide important information for the development of a geological 3D model of the deposit and for validating the interpretation of the zone in front of the face. The results will help to optimize cavern operation and to develop a selective brine concept for new and extended caverns. An example is presented to show the analysis procedure, from data acquisition to data processing to the establishment of the geological model of the deposit and cavern field. (orig.)

  20. ATLAS Christmas lunch

    CERN Multimedia

    Francois Butin; Markus Nordberg

    The end of the year ATLAS pit lunch is now a well established tradition: the 4th edition took place in the most prestigious place at CERN; the "Globe de l'innovation", or simply "the Globe". This end-of-year event is the opportunity to thank all those working so hard at Point 1. The first event took place in December 2003. At that time, there was no Globe yet, and the party took place in SX1 building, at the top of the shafts leading to the ATLAS cavern, with some 100 guests. In December 2004, we had the privilege to be the first to organize a lunch in the Globe with some 200 guests. Since then, many have followed our example! Well, almost: we were requested to refrain from serving "Tartiflette" again in there (a Savoyard specialty, using vast amounts of Reblochon, a smelly cheese...). It was said to have left a poignant odour for following events throughout 2004... Long queues formed for this special event. In December 2005, we were authorized to party in the Globe again (once we promised we would b...

  1. 30 January 2012 - Danish National Research Foundation Chairman of board K. Bock and University of Copenhagen Rector R. Hemmingsen visiting ATLAS underground experimental area, CERN Control Centre and ALICE underground experimental area, throughout accompanied by J. Dines Hansen and B. Svane Nielsen; signing the guest book with CERN Director for Research and Scientific Computing S. Bertolucci and Head of International Relations F. Pauss.

    CERN Multimedia

    Jean-Claude Gadmer

    2012-01-01

    30 January 2012 - Danish National Research Foundation Chairman of board K. Bock and University of Copenhagen Rector R. Hemmingsen visiting ATLAS underground experimental area, CERN Control Centre and ALICE underground experimental area, throughout accompanied by J. Dines Hansen and B. Svane Nielsen; signing the guest book with CERN Director for Research and Scientific Computing S. Bertolucci and Head of International Relations F. Pauss.

  2. Cerebral cavernous malformations. Serial magnetic resonance imaging findings in patients with and without gamma knife surgery

    Energy Technology Data Exchange (ETDEWEB)

    Yoon Pyeong-Ho; Kim, Dong-Ik; Jeon Pyoung; Ryu, Young-Hoon; Hwang, Geum-Joo; Park, Sang-Joon [Yonsei Univ., Seoul (Korea, Republic of). Coll. of Medicine

    1998-10-01

    To classify the cerebral cavernous malformations and to investigate the natural history of cavernous malformations according to the classification, 41 patients with 61 cavernous malformations (40 cavernous malformations from 22 patients treated with gamma knife surgery) were regularly followed up using MR imaging for a mean period of 25.5 months in treated cavernous malformations and 20.7 months in untreated cavernous malformations, respectively. Cavernous malformations were classified into four types. Follow-up MR images were analyzed to evaluate changes in size, signal intensity, rebleeding, and perilesional adverse reaction of irradiation. A total of 61 cavernous malformations including 17 in type I, 23 in type II, 10 in type III, and 11 in type IV showed usual degradation of blood product in 22 cavernous malformations, no change in shape and signal intensity in 31 cavernous malformations, and eight cavernous malformations with rebleedings in the serial MR images. In these eight cavernous malformations with rebleedings, six occurred in type II and two in type III, but none in type I or IV. Rebleedings were more frequent in type II than in other types. Adverse reaction of irradiation was observed in five of 22 patients treated with gamma knife surgery. Although most cerebral cavernous malformations showed evolution of hemorrhage or no change in size or shape on follow-up MR images, cerebral cavernous malformations represented as mixture of subacute and chronic hemorrhage with hemosiderin rim (type II) have a higher frequency to rebleed than other types of cerebral cavernous malformations. Cerebral cavernous malformations represented as hemosiderin deposition without central core (type IV) have a lower tendency to rebleed than other types and do not need any treatment. Most of the adverse reaction of irradiation after gamma knife surgery around cavernous malformations are transient findings and are considered to be perilesional edema. (K.H)

  3. Features of Bayou Choctaw SPR caverns and internal structure of the salt dome.

    Energy Technology Data Exchange (ETDEWEB)

    Munson, Darrell E.

    2007-07-01

    The intent of this study is to examine the internal structure of the Bayou Choctaw salt dome utilizing the information obtained from graphical representations of sonar survey data of the internal cavern surfaces. Many of the Bayou Choctaw caverns have been abandoned. Some existing caverns were purchased by the Strategic Petroleum Reserve (SPR) program and have rather convoluted histories and complex cavern geometries. In fact, these caverns are typically poorly documented and are not particularly constructive to this study. Only two Bayou Choctaw caverns, 101 and 102, which were constructed using well-controlled solutioning methods, are well documented. One of these was constructed by the SPR for their use while the other was constructed and traded for another existing cavern. Consequently, compared to the SPR caverns of the West Hackberry and Big Hill domes, it is more difficult to obtain a general impression of the stratigraphy of the dome. Indeed, caverns of Bayou Choctaw show features significantly different than those encountered in the other two SPR facilities. In the number of abandoned caverns, and some of those existing caverns purchased by the SPR, extremely irregular solutioning has occurred. The two SPR constructed caverns suggest that some sections of the caverns may have undergone very regular solutioning to form uniform cylindrical shapes. Although it is not usually productive to speculate, some suggestions that point to the behavior of the Bayou Choctaw dome are examined. Also the primary differences in the Bayou Choctaw dome and the other SPR domes are noted.

  4. ADVANCED UNDERGROUND GAS STORAGE CONCEPTS REFRIGERATED-MINED CAVERN STORAGE

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-09-01

    Limited demand and high cost has prevented the construction of hard rock caverns in this country for a number of years. The storage of natural gas in mined caverns may prove technically feasible if the geology of the targeted market area is suitable; and economically feasible if the cost and convenience of service is competitive with alternative available storage methods for peak supply requirements. It is believed that mined cavern storage can provide the advantages of high delivery rates and multiple fill-withdrawal cycles in areas where salt cavern storage is not possible. In this research project, PB-KBB merged advanced mining technologies and gas refrigeration techniques to develop conceptual designs and cost estimates to demonstrate the commercialization potential of the storage of refrigerated natural gas in hard rock caverns. Five regions of the U.S.A. were studied for underground storage development and PB-KBB reviewed the literature to determine if the geology of these regions was suitable for siting hard rock storage caverns. Area gas market conditions in these regions were also studied to determine the need for such storage. Based on an analysis of many factors, a possible site was determined to be in Howard and Montgomery Counties, Maryland. The area has compatible geology and a gas industry infrastructure for the nearby market populous of Baltimore and Washington D.C.. As Gas temperature is lowered, the compressibility of the gas reaches an optimum value. The compressibility of the gas, and the resultant gas density, is a function of temperature and pressure. This relationship can be used to commercial advantage by reducing the size of a storage cavern for a given working volume of natural gas. This study looks at this relationship and and the potential for commercialization of the process in a storage application. A conceptual process design, and cavern design were developed for various operating conditions. Potential site locations were considered

  5. 2nd February 2011-Vice-Chancellor of Jammu University-Prof. Varun Sahni-India visiting ALICE cavern and LHC Tunnel

    CERN Multimedia

    Sylvain Chapeland

    2011-01-01

    Photo 1-2,4-8:The delegation visiting the ATLAS cavern Photo 3:ALICE Collaboration Spokesperson P. Giubellino+ALICE Collaboration University of Jammu S. Mahajan+ALICE Collaboration University of Jammu A. Bhasin+ALICE Collaboration Universita degli Studi di Torino R. Bala+V. Sahni+Adviser for India R.Voss+S. Arriaga+ALICE Collaboration University of Jammu A. Gupta Photo 9-13:The delegation visiting the LHC tunnel at Point 2 Photo 14-22: Signature of the Guest Book with R. Voss

  6. Making ATLAS Data from CERN Accessible to the General Public: The Development and Evaluation of a Learning Resource in Experimental Particle Physics

    CERN Document Server

    AUTHOR|(CDS)2243922; Ekelin, Svea Magdalena; Lund-Jensen, Bengt; Christiansen, Iben

    2017-08-15

    In 2016, the ATLAS experiment at CERN released data from 100 trillion proton-proton collisions to the general public. In connection to this release the ATLAS Outreach group has developed several tools for visualizing and analyzing the data, one of which is a Histogram analyzer. The focus of this project is to bridge the gap between the general public's knowledge in physics and what is needed to use this Histogram analyzer. The project consists of both the development and an evaluation of a learning resource that explains experimental particle physics for a general public audience. The learning resource is a website making use of analogies and two perspectives on learning: Variation Theory and Cognitive Load Theory. The evaluation of the website was done using a survey with 10 respondents and it focused on whether analogies and the perspectives on learning helped their understanding. In general the respondents found the analogies to be helpful for their learning, and to some degree they found the explanations ...

  7. Concomitant multiple cavernous hemangiomas and venous angioma of the orbit.

    Science.gov (United States)

    Wang, Xianggui; Yan, Jianhua

    2014-07-01

    The coexistence of multiple cavernous hemangiomas and venous malformation is an extremely rare clinical condition. In this report, we describe a patient showing initial multiple cavernous hemangiomas followed years later by a recurrence of multiple cavernous hemangiomas along with the appearance of venous angioma coexisting in the same orbit. A 52-year-old woman was referred with a gradually progressive proptosis and upward displacement of her left eye that were present for 10 years. The clinical features, computed tomography and ultrasonography examination, surgery, and histopathologic findings from this patient with multiple cavernous hemangiomas coexisting with venous angioma in the same orbit are presented. Color Doppler ultrasonography and computed tomography scan displayed more than 10 well-defined homogenous masses in the left orbit measuring 0.5 × 0.5 to 1.0 × 0.8 cm with no blood flow. Anterior orbitotomy of the left eye was performed. Fifteen accessible, distinct, red-purple, round masses were excised with tumors measuring 0.5 × 0.5 × 0.6 to 1.0 × 1.0 × 1.0 cm. Histopathologic analysis confirmed the diagnosis of multiple cavernous hemangiomas. Eight years later, she again developed left proptosis. Color Doppler ultrasonography and computed tomography disclosed multiple smoothly outlined homogeneous masses in the left orbit ranging in size from 5 × 4 to 28 × 16 mm, along with some scattered, high-density, vein-stone shadows within the mass. An anterior orbitotomy was again performed. At surgery, 4 violaceous, well-defined, and cone-shaped masses were removed with minimal bleeding. Histopathologic examination confirmed the diagnosis of multiple cavernous hemangiomas with coexisting venous angioma. There was no recurrence of orbital hemangioma at 2 years after the second surgery. Orbital cavernous hemangioma and venous angioma may share a yet-to-be-described common link.

  8. Transvenous embolization of a carotid cavernous fistula complicated by a hematoma at the tentorial edge.

    Science.gov (United States)

    Baharvahdat, Humain; Shabestari, Mahmoud M; Zabihyan, Samira; Etemadresaei, Hamid; Blanc, Raphäel; Piotin, Michel

    2014-01-01

    Indirect (dural) carotid cavernous fistulae are generally treated by endovascular surgery primary transvenous embolization that is safe and effective. We describe here a case of a left indirect carotid cavernous fistula that presented with proptosis and eye redness. The patient underwent transvenous embolization of carotid cavernous sinus. The procedure was complicated by a haemorrhage from the cavernous sinus. The post procedural CT scan showed a haematoma at the tentorial edge. Precise diagnosis and prompt treatment could prevent severe complications.

  9. Cavernous hemangioma of the submandibular gland with parapharyngeal extension in an adult: Case report.

    Science.gov (United States)

    Azadarmaki, Roya; Then, Matthew T; Walia, Rohit; Lango, Miriam N

    2016-02-01

    Cavernous hemangiomas of the submandibular gland are rare. Signs and symptoms typically resemble those of sialolithiasis and chronic sialadenitis. If a lesion extends into the parapharyngeal space, otalgia and sore throat can result. Spontaneous regression is not a characteristic of cavernous hemangiomas. Surgical excision is a management option. We report the case of an adult with a submandibular gland cavernous hemangioma with parapharyngeal extension.

  10. Diagnostic imaging of cerebral cavernous angioma : case report and review of the literature

    OpenAIRE

    Darocha, Janusz; Homa, Jarosław; Dudek, Daniel; Guz, Wiesław; Samojedny, Antoni

    2014-01-01

    Background: Cerebrovascular malformations are classified as cavernous malformations, arteriovenous malformations, developmental venous anomalies and capillary telangiectasias. Cavernous angioma is the second most common form of cerebrovascular malformations and constitutes up to 10-15% of the total incidence rate. Clinical features include epilepsy, focal deficits, headaches, or hemorrhages; cavernous angioma may also remain clinically silent. Case Report: Presented is a rare case of multiple...

  11. Combination Therapy Using Human Adipose-derived Stem Cells on the Cavernous Nerve and Low-energy Shockwaves on the Corpus Cavernosum in a Rat Model of Post-prostatectomy Erectile Dysfunction.

    Science.gov (United States)

    Jeon, Seung Hwan; Shrestha, Kshitiz Raj; Kim, Richard Y; Jung, Ae Ryang; Park, Yong Hyun; Kwon, Ohseong; Kim, Ga Eun; Kim, So Hyun; Kim, Ki Hean; Lee, Ji Youl

    2016-02-01

    To investigate combined therapeutic efficacy of human adipose-derived stem cells (h-ADSCs) application on injured cavernous nerve and low-energy shockwave therapy (SWT) on the corpus cavernosum in a rat model of post-prostatectomy erectile dysfunction. Rats were randomly divided into 5 groups: control, bilateral cavernous nerve injury (BCNI), adipose-derived stem cell (ADSC) (BCNI group with h-ADSCs on the cavernous nerve), SWT (BCNI group with low-energy SWT on the corpus cavernosum), and ADSC/SWT (BCNI group with a combination of h-ADSCs and low-energy SWT). After 4 weeks, erectile function was assessed using intracavernosal pressure. The cavernous nerves and penile tissue were evaluated through immunostaining, Western blotting, and a cyclic guanosine monophosphate assay. ADSC/SWT significantly improved intracavernosal pressure compared to the other experimental group. ADSC had significantly increased β-III tubulin expression of the cavernous nerve, and SWT had a markedly enhanced vascular endothelial growth factor expression in corpus cavernosum. The ADSC/SWT group had a significantly increased in alpha smooth muscle actin content (P corpus cavernosum. In this study, h-ADSCs showed an effect on the recovery of injured cavernous nerve and low-energy SWT improved angiogenesis in the corpus cavernosum. The h-ADSCs combined with low-energy SWT showed beneficial effect on the recovery of erectile function in a rat model of postprostatectomy erectile dysfunction. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. CAVERN ROOF STABILITY FOR NATURAL GAS STORAGE IN BEDDED SALT

    Energy Technology Data Exchange (ETDEWEB)

    DeVries, Kerry L; Mellegard, Kirby D; Callahan, Gary D; Goodman, William M

    2005-06-01

    This report documents research performed to develop a new stress-based criterion for predicting the onset of damage in salt formations surrounding natural gas storage caverns. Laboratory tests were conducted to investigate the effects of shear stress, mean stress, pore pressure, temperature, and Lode angle on the strength and creep characteristics of salt. The laboratory test data were used in the development of the new criterion. The laboratory results indicate that the strength of salt strongly depends on the mean stress and Lode angle. The strength of the salt does not appear to be sensitive to temperature. Pore pressure effects were not readily apparent until a significant level of damage was induced and the permeability was increased to allow penetration of the liquid permeant. Utilizing the new criterion, numerical simulations were used to estimate the minimum allowable gas pressure for hypothetical storage caverns located in a bedded salt formation. The simulations performed illustrate the influence that cavern roof span, depth, roof salt thickness, shale thickness, and shale stiffness have on the allowable operating pressure range. Interestingly, comparison of predictions using the new criterion with that of a commonly used criterion indicate that lower minimum gas pressures may be allowed for caverns at shallow depths. However, as cavern depth is increased, less conservative estimates for minimum gas pressure were determined by the new criterion.

  13. Surgical Outcomes of Cavernous Sinus Syndrome in Pituitary Adenomas.

    Science.gov (United States)

    Fu, Weilun; Duan, Lian; Geng, Sumin

    2017-11-01

    The type of pituitary adenoma with a manifestation that includes cavernous sinus syndrome is rare. Based on the clinical data of 70 patients, this study investigated the pathogenesis, imaging characteristics, and prognostic factors of pituitary adenoma with cavernous sinus syndrome. We conducted a retrospective analysis of the characteristics of patients with pituitary adenoma with cavernous sinus syndrome who received surgical treatment. The patients were classified into different prognosis groups according to the time required for them to recover from the cavernous sinus syndrome. Univariate analyses were conducted for the correlations between the prognosis and factors. Of the 3598 cases of pituitary adenomas, 70 (1.95%) presented cavernous sinus syndrome. Of the patients, 55.7% recovered within 2 weeks of surgery, 24.3% recovered from 2 weeks to 1 year after surgery, and 20% had not returned to normal after more than 1 year after surgery. Univariate analyses showed that shorter disease duration (P syndrome differs depending on the mechanism of the syndrome. There was no significant difference in the prognosis between patients with total pituitary adenoma resection and subtotal resection. Timely surgery within 100 days of symptom occurrence, Knosp grade 0-2, and associated pituitary apoplexy are predictive factors of good prognosis. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. Propranolol Treatment of Cavernous Malformations with Symptomatic Hemorrhage.

    Science.gov (United States)

    Zabramski, Joseph M; Kalani, M Yashar S; Filippidis, Aristotelis S; Spetzler, Robert F

    2016-04-01

    Cerebral cavernous malformations are more common than generally thought, affecting approximately 1 in every 250 adults. Most of these lesions are asymptomatic or have a relatively benign course, but a small minority behave aggressively and present with recurrent episodes of symptomatic hemorrhage. A safe and effective medical treatment option for the management of this latter group would be useful. Propranolol has recently been shown to be effective in the treatment of infantile hemangioma, a close pathologic counterpart of cavernous malformations. These results suggest a potential role for propranolol treatment in the management of patients with symptomatic cavernous malformations. Low-dose propranolol (20 mg, three times daily) was used to treat 2 adult female patients in their mid- to late fifties, both of whom had symptomatic cavernous malformations and a history of repeated hemorrhage. Serial magnetic resonance imaging studies after the initiation of propranolol demonstrated regression of the lesions and no evidence of recurrent hemorrhage. Propranolol may offer a safe and effective treatment for patients who have cavernous malformations with symptomatic hemorrhage. Additional studies are needed to confirm these findings. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. Pharmacodynamics of intracavernously injected drugs and cavernous wall resistance.

    Science.gov (United States)

    de Meyer, J M; Oosterlinck, W

    1997-01-01

    It was our aim to investigate whether drug transfer from the cavernous bodies to the systemic circulation after intracavernous (i.c.) injection is influenced by the resistance of the cavernous wall. i.c. injection of 62.5 micrograms digoxin as a tracer. (1) In 32 volunteers; in 5 together with the vasocontractor norepinephrine, in 20 together with a 'trimix' of vasodilators, in 7 alone without vasoactive drug. Plasma digoxin levels were measured after 5, 10 and 15 min. (2) Together with a trimix of vasodilators, in 30 men presenting a normal cavernosometry and in 30 men presenting an abnormal one. Plasma digoxin levels were measured after 2, 3, 5, 6, 10 and 15 min. (1) One minute after i.c. injection, the plasma peak of digoxin was 40 times higher (p < 0.01) after injection with norepinephrine than after injection with vasodilators. (2) There was a statistically significantly (p < 0.01) higher plasma digoxin level 5, 6, 10 and 15 min after injection in the 30 patients presenting an abnormal cavernosometry than in the 30 patients presenting a normal one. Drug transfer from the cavernous bodies to the systemic circulation is highly influenced by the resistance of the cavernous wall. It seems possible to diagnose cavernous leakage by means of a peripheral dosage of a routinely dosable drug, injected i.c. together with vasodilators.

  16. Diffuse Cavernous Hemangioma of the Colon.

    Science.gov (United States)

    Mirioglu, S; Cavus, B; Iliaz, R; Besisik, F

    2016-01-01

    A 70-year-old man was admitted to our clinic with a history of rectal bleeding and constipation, his colonoscopy revealed varicosities and bluish nodular lesions of the rectum (Figure 1). Abdominal CT showed multiple nodular lesions beginning from the distal descending colon and extending to the rectum, calcifications suggesting phleboliths were also seen in these lesions. A contrast enhanced pelvic MRI demonstrated multiple tubular lesions showing hyperintensity on T2-weighted images and hypointensity on T1-weighted images, consistent with the affected areas on the CT scan (Figure 2). It was a diffuse cavernous hemangioma, which mostly affects the rectosigmoid colon in the gastrointestinal tract, and can clinically mimic internal hemorrhoids, ulcerative colitis or cancer (1). Gastrointestinal hemangioma is a rare benign vascular neoplasm, and might be associated with a congenital disorder like Osler-Weber-Rendu disease, Maffucci's syndrome, Klippel-Trénaunay syndrome, or the congenital blue rubber bleb nevus syndrome (2). Even though there are different medical treatment options targeting VEGF and FGF-mediated pathways such as bevacizumab and thalidomide, and endoscopic approaches like sclerotherapy and electrocautery; complete resection of the hemangioma is the only curative treatment method (1, 3). Therefore, the patient was referred to department of surgery for a definitive treatment, and lost to follow-up.

  17. Surgical treatment of cerebral cavernous malformations.

    Science.gov (United States)

    Davies, J M; Kim, H; Lawton, M T

    2015-09-01

    Cerebral cavernous malformations (CMs) are clusters of abnormally-formed, thin-walled blood vessels that tend to hemorrhage, resulting in focal neurological deficits, seizures, and even death, depending on the location of the lesion and extent of bleeding. Management of cerebral CMs can be reduced to the decision to observe or to surgically resect. The objective of the paper was to review options for surgical management of cerebral CMs. A university-based CM practice was examined for: 1) anatomical distribution of operatively managed CMs; and 2) surgical approaches to eloquent CMs. Although cerebral CMs can occur throughout the brain and can lead to significant neurological morbidity, even in highly eloquent locations, such as the brainstem, thalamus, and basal ganglia, experience demonstrates that the majority of CMs can be safely resected and that patients tend to experience long-term improvement in neurological function. The keys to good patient outcomes lie in appropriate patient selection and in thoughtful choice of a surgical approach that minimizes transgression of normal structures.

  18. Vascular permeability in cerebral cavernous malformations.

    Science.gov (United States)

    Mikati, Abdul G; Khanna, Omaditya; Zhang, Lingjiao; Girard, Romuald; Shenkar, Robert; Guo, Xiaodong; Shah, Akash; Larsson, Henrik B W; Tan, Huan; Li, Luying; Wishnoff, Matthew S; Shi, Changbin; Christoforidis, Gregory A; Awad, Issam A

    2015-10-01

    Patients with the familial form of cerebral cavernous malformations (CCMs) are haploinsufficient for the CCM1, CCM2, or CCM3 gene. Loss of corresponding CCM proteins increases RhoA kinase-mediated endothelial permeability in vitro, and in mouse brains in vivo. A prospective case-controlled observational study investigated whether the brains of human subjects with familial CCM show vascular hyperpermeability by dynamic contrast-enhanced quantitative perfusion magnetic resonance imaging, in comparison with CCM cases without familial disease, and whether lesional or brain vascular permeability correlates with CCM disease activity. Permeability in white matter far (WMF) from lesions was significantly greater in familial than in sporadic cases, but was similar in CCM lesions. Permeability in WMF increased with age in sporadic patients, but not in familial cases. Patients with more aggressive familial CCM disease had greater WMF permeability compared to those with milder disease phenotype, but similar lesion permeability. Subjects receiving statin medications for routine cardiovascular indications had a trend of lower WMF, but not lesion, permeability. This is the first demonstration of brain vascular hyperpermeability in humans with an autosomal dominant disease, as predicted mechanistically. Brain permeability, more than lesion permeability, may serve as a biomarker of CCM disease activity, and help calibrate potential drug therapy.

  19. Multiple cerebrospinal cavernous angiomas.

    Science.gov (United States)

    Kodeeswaran, M; Udesh, Reshmi; Ramya, L; Jothi Kumar, S

    2016-09-20

    Cavernous angiomas represent 5-12% of all spinal vascular lesions and 1% of all intramedullary lesions in pediatric patients. Intramedullary spinal cavernomas are relatively rare with only 24 cases reported till date to the best of our knowledge. A 15 -year-old boy presented to the clinic with acute onset motor weakness in all four limbs. He was diagnosed with multiple cerebral cavernomas and an acutely bleeding spinal cavernoma. Complete surgical excision of the spinal cavernoma was done. Postoperatively the patient's weakness gradually improved to a power of 4/5 in all his limbs over a period of 10 days. Only 24 cases of pediatric spinal cavernomas have been reported in the current literature. Current consensus on management of these rare lesions is based on previously published case reports/series and surgery appears to be the only definitive treatment. Further studies regarding any non-surgical expectant management appears warranted. Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author 2016.

  20. Vascular permeability in cerebral cavernous malformations

    Science.gov (United States)

    Mikati, Abdul G; Khanna, Omaditya; Zhang, Lingjiao; Girard, Romuald; Shenkar, Robert; Guo, Xiaodong; Shah, Akash; Larsson, Henrik BW; Tan, Huan; Li, Luying; Wishnoff, Matthew S; Shi, Changbin; Christoforidis, Gregory A; Awad, Issam A

    2015-01-01

    Patients with the familial form of cerebral cavernous malformations (CCMs) are haploinsufficient for the CCM1, CCM2, or CCM3 gene. Loss of corresponding CCM proteins increases RhoA kinase-mediated endothelial permeability in vitro, and in mouse brains in vivo. A prospective case-controlled observational study investigated whether the brains of human subjects with familial CCM show vascular hyperpermeability by dynamic contrast-enhanced quantitative perfusion magnetic resonance imaging, in comparison with CCM cases without familial disease, and whether lesional or brain vascular permeability correlates with CCM disease activity. Permeability in white matter far (WMF) from lesions was significantly greater in familial than in sporadic cases, but was similar in CCM lesions. Permeability in WMF increased with age in sporadic patients, but not in familial cases. Patients with more aggressive familial CCM disease had greater WMF permeability compared to those with milder disease phenotype, but similar lesion permeability. Subjects receiving statin medications for routine cardiovascular indications had a trend of lower WMF, but not lesion, permeability. This is the first demonstration of brain vascular hyperpermeability in humans with an autosomal dominant disease, as predicted mechanistically. Brain permeability, more than lesion permeability, may serve as a biomarker of CCM disease activity, and help calibrate potential drug therapy. PMID:25966944

  1. Spontaneous Direct Carotid-Cavernous Fistula in an Elderly Patient

    Directory of Open Access Journals (Sweden)

    Sirakov Stanimir S.

    2017-12-01

    Full Text Available We describe the case of an 83-year-old woman with left-sided ophthalmoplegia. She had no family history of connective tissue disease. The computed tomography study found a dilated left cavernous sinus. The conventional cerebral panangiography confirmed the diagnosis - a direct carotid-cavernous fistula (CCF, with no evidence of ruptured aneurysm. The woman underwent endovascular treatment with coiling of the cavernous sinus in combination with application of the Onyx embolic agent in the fistula. During the first 48 hours after the embolization the local pain, exophthalmos and conjunctival injection of the left eye were significantly ameliorated. The pulsatile tinnitus on the left disappeared and the ptosis of the left eyelid partially recovered. Selective angiography is the best method for the diagnosis and classification of CCF. Currently, treatment is possible with low mortality and morbidity rates. The endovascular intervention is able to completely occlude the fistula and maintain adequate blood fl ow through the carotid artery.

  2. Concomitant cavernous hemangioma and venous angioma of the orbit.

    Science.gov (United States)

    Kodama, Tatsuo; Tane, Nobuhiro; Ohira, Akihiro; Matsuoka, Yotaro; Maruyama, Riruke

    2004-01-01

    An unusual case of cavernous hemangioma coexisting with venous angioma in the ipsilateral orbit is described. A 67-year-old woman had a mass in the lower eyelid of her right eye and proptosis. Imaging examinations showed two masses connected to each other in the extraconal space of the right orbit. Anterior orbitotomy was performed to remove the tumors. Histopathological evaluation of the anteriorly located tumor revealed cavernous hemangioma. The posteriorly located tumor was found to be a venous angioma. Endothelial cells in both tumors showed positive immunostaining for factor VIII-related antigen and smooth muscle actin. Immunoreactivity of smooth muscle actin was more prominent in the interstitium of the posteriorly located tumor. Coexistence of cavernous hemangioma and venous angioma in the same area suggests that they are a continuum and of the same origin. Copyright Japanese Ophthalmological Society 2004

  3. Optical stimulation of the cavernous nerves in the rat prostate

    Science.gov (United States)

    Fried, Nathaniel M.; Lagoda, Gwen A.; Scott, Nicholas J.; Su, Li-Ming; Burnett, Arthur L.

    2008-02-01

    Laser nerve stimulation has recently been studied as an alternative to electrical stimulation in neuroscience. Advantages include non-contact stimulation, improved spatial selectivity, and elimination of electrical stimulation artifacts. This study explores laser stimulation of the rat cavernous nerves, as a potential alternative to electrical nerve mapping during nerve-sparing radical prostatectomy. The cavernous nerves were surgically exposed in a total of 10 male rats. A Thulium fiber laser stimulated the nerves, with a wavelength of 1870 nm, pulse energy of 7.5 mJ, radiant exposure of 1 J/cm2, pulse duration of 2.5 ms, pulse rate of 10 Hz, and 1-mm laser spot diameter, for a stimulation time of 60 s. A significant increase in the intracavernosal pressure was detected upon laser stimulation, with pressure returning to baseline levels after stimulation. This study demonstrates the feasibility of non-contact laser stimulation of the cavernous nerves using near-infrared laser radiation.

  4. Cavernous hemangioma of the posterior mediastinum with bony invasion.

    Science.gov (United States)

    Yun, Takamasa; Suzuki, Hidemi; Tagawa, Tetsuzo; Iwata, Takekazu; Mizobuchi, Teruaki; Yoshida, Shigetoshi; Yamazaki, Masashi; Yoshino, Ichiro

    2016-01-01

    We herein report a case of a cavernous hemangioma of the posterior mediastinum treated with surgical resection. Mediastinal hemangiomas are rare and diagnosis is difficult prior to operation. A 58-year-old female was referred to our hospital for back pain and a tumor in the left posterior mediastinum that was detected by chest computed tomography (CT). CT showed a tumor adjacent to the left side of the fifth thoracic vertebrae measuring 60 × 50 mm with invasion into and destruction of the 5th rib. The tumor was resected successfully via hemilaminectomy with costotransversectomy, and was revealed to be a cavernous hemangioma histologically. 1 year and 5 months after surgery, the patient was asymptomatic and without a recurrence. Hemangiomas are usually considered benign but sometimes behave aggressively with destruction of the neighboring structures. We consider en bloc resection to be safe and effective for aggressive cavernous hemangiomas of the posterior mediastinum.

  5. Cavernous neurotomy causes hypoxia and fibrosis in rat corpus cavernosum.

    Science.gov (United States)

    Leungwattanakij, Somboon; Bivalacqua, Trinity J; Usta, Mustafa F; Yang, Dae-Yul; Hyun, Jae-Seog; Champion, Hunter C; Abdel-Mageed, Asim B; Hellstrom, Wayne J G

    2003-01-01

    The etiologies of erectile dysfunction (ED) after nerve-sparing radical prostatectomy have not been clearly elucidated. The aim of this study was to evaluate the effects of cavernous nerve injury on cavernous fibrosis, and to consider measures to prevent irreversible damage to the cavernous tissues. Twenty male Sprague-Dawley rats constituted the study population. The animals were divided into 2 groups; group 1 consisted of sham-operated rats (n = 10), and group 2 consisted of rats that underwent incision of both cavernous nerves (n = 10). Three months later, all rats underwent intracavernous papaverine injection (300 and 600 mg), and intracorporal pressures were recorded. Transforming growth factor-beta(1) (TGF-beta(1)) messenger RNA (mRNA) expression from rat penile tissue was measured using reverse transcriptase-polymerase chain reaction. Hypoxia-inducible factor-1alpha (HIF-1alpha), TGF-beta(1), and collagen I and III protein expressions were determined by Western blot analysis and immunohistochemical staining. Erectile function as studied with intracavernosal papaverine injection and histological analysis of penile cross-sections at 3 months was similar in both groups. TGF-beta(1) mRNA expression, HIF-1alpha, TGF-beta(1), and collagen I and III protein expressions were significantly greater in the neurotomy group. Immunohistochemical staining for TGF-beta(1), HIF-1alpha, and collagen III were qualitatively more positive in the neurotomy group, whereas collagen I staining was similar. This study demonstrates an increase in TGF-beta(1), HIF-1alpha, and collagen III synthesis in rat cavernosal smooth musculature after cavernous neurotomies. In theory, cavernous fibrosis may be reduced by employing various vasoactive agents or interventions that increase oxygenation to the corporal tissues during the postoperative period.

  6. 28 August 2013 - Director of Technical Quality Management Head of ESTEC Establishment European Space Agency F. Ongaro visiting the LHC tunnel at Point 1 with Technology Department Head F. Bordry and Technology Department J.-P. Tock; visiting the ATLAS experimental area with ATLAS Deputy Spokesperson T. Wengler and signing the guest book with CERN Director-General R. Heuer. Accompanied throughout by F. Bordry and V. Parma.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    28 August 2013 - Director of Technical Quality Management Head of ESTEC Establishment European Space Agency F. Ongaro visiting the LHC tunnel at Point 1 with Technology Department Head F. Bordry and Technology Department J.-P. Tock; visiting the ATLAS experimental area with ATLAS Deputy Spokesperson T. Wengler and signing the guest book with CERN Director-General R. Heuer. Accompanied throughout by F. Bordry and V. Parma.

  7. Clinical spectrum of spontaneous carotid-cavernous fistula

    Directory of Open Access Journals (Sweden)

    Das Jayanta

    2007-01-01

    Full Text Available A carotid-cavernous fistula (CCF is an abnormal communication between the cavernous sinus and the carotid arterial system. A CCF is divided into two categories, direct and indirect. Direct fistulas usually account for 70 to 90% of all CCF. Spontaneous, low-flow fistulas are usually associated with atherosclerosis, hypertension and collagen vascular disease or may develop in females during peripartum period. The elderly age group, especially women are at increased risk. We report three cases of spontaneous CCF presenting with ocular manifestations and hypertension, without any collagen vascular disease. One case was a direct variety and the other two were of indirect variety.

  8. Congenital bilateral plexiform neurofibromas of the cavernous sinuses

    Energy Technology Data Exchange (ETDEWEB)

    Meersschaut, V.A.; Kros, J.M.; Catsman-Berrevoets, C.E.; Lequin, M.H. [Dept. of Paediatric Radiology, Univ. Hospital Rotterdam, Rotterdam (Netherlands)

    2003-04-01

    We report the CT and MRI findings of congenital bilateral plexiform neurofibromas of the cavernous sinuses in a 2-month-old girl. Contrast-enhanced CT showed enhancement of masses in both cavernous sinuses and enlargement of both superior orbital fissures. On MRI the masses were isointense with muscle on T1-weighted images, hypointense on T2-weighted images and showed strong homogeneous enhancement on contrast-enhanced T1-weighted images. A dural tail sign was observed. The diagnosis was proven by biopsy. (orig.)

  9. The big wheels of ATLAS

    CERN Multimedia

    2006-01-01

    The ATLAS cavern is filling up at an impressive rate. The installation of the first of the big wheels of the muon spectrometer, a thin gap chamber (TGC) wheel, was completed in September. The muon spectrometer will include four big moving wheels at each end, each measuring 25 metres in diameter. Of the eight wheels in total, six will be composed of thin gap chambers for the muon trigger system and the other two will consist of monitored drift tubes (MDTs) to measure the position of the muons (see Bulletin No. 13/2006). The installation of the 688 muon chambers in the barrel is progressing well, with three-quarters of them already installed between the coils of the toroid magnet.

  10. Radiological features of childhood giant cavernous malformations

    Energy Technology Data Exchange (ETDEWEB)

    Ozgen, Burce; Senocak, Efsun; Oguz, Kader K. [Hacettepe University, Department of Radiology, Faculty of Medicine, Ankara (Turkey); Soylemezoglu, Figen [Hacettepe University, Department of Pathology, School of Medicine, Ankara (Turkey); Akalan, Nejat [Hacettepe University, Department of Neurosurgery, School of Medicine, Ankara (Turkey)

    2011-04-15

    Giant cavernous malformations (GCM) are very large, low-flow vascular malformations, which usually have atypical imaging features and are commonly misdiagnosed preoperatively as neoplasms or vascular malformations. These lesions have mostly been reported in children. As cavernomas show different features in children compared to adults, we evaluated the imaging features of pediatric GCMs in order to help in the preoperative diagnosis of these malformations. Brain MR studies of nine children (mean age of 4 years; 8 months-9 years) with biopsy-proven GCM were retrospectively evaluated. We defined GCMs as cavernomas of {>=}4 cm. Lesions were evaluated regarding their size, location, signal characteristics, general appearance (uni/multilocular) as well as regarding the presence of mass effect, edema, and fluid-fluid levels and were classified according to the Mottolese classification of pediatric cavernomas. Lesion locations were parietal (n = 5), frontal (n = 2), temporal, and intraventricular. Seven lesions were in the periventricular region (with five in the periatrial region). Six patients had T1 hyperintense multilobulated lesions with ''bubbles of blood'' appearance and three patients had heterogeneous lesions with reticular core. All lesions had mass effect, edema (marked in four cases), and peripheral hemosiderin rim. Fluid-fluid levels were also common (n = 7). Most of our lesions (six of nine) were classified as type IIIA, two as type IIIC, and one as type IA. In children, a GCM should be considered in case of very large hemorrhagic intra-axial mass with ''bubbles of blood'' multicystic appearance, surrounding hemosiderin ring, fluid-fluid levels, and accompanying edema-mass effect, especially in the periatrial location. (orig.)

  11. Characterization of radiation-induced cavernous malformations and comparison with a nonradiation cavernous malformation cohort.

    Science.gov (United States)

    Cutsforth-Gregory, Jeremy K; Lanzino, Giuseppe; Link, Michael J; Brown, Robert D; Flemming, Kelly D

    2015-05-01

    The objective of this study was to characterize the clinical features of radiation-induced cavernous malformations (RICMs). The authors retrospectively reviewed the clinical and radiological characteristics of patients with RICMs. The features of these RICMs were then compared with features of nonradiation cavernous malformations (CMs) in 270 patients. Thirty-two patients with RICMs were identified (56.2% men), with a median age of 31.1 years at RICM diagnosis. The median latency from radiation treatment to RICM diagnosis was 12.0 years (interquartile range 5.0-19.6 years). RICMs were always within the previous radiation port. RICMs were symptomatic at diagnosis in 46.9%, and were associated with symptomatic intracranial hemorrhage at any time in 43.8%. Older age at the time of radiation treatment and higher radiation dose were associated with shorter latency. RICMs tended to be diagnosed at a younger age than nonradiation CMs (median 31.1 vs 42.4 years, respectively; p = 0.054) but were significantly less likely to be symptomatic at the time of diagnosis (46.9% vs 65.8%, respectively; p = 0.036). RICMs were more likely to be multiple CMs than nonradiation CMs (p = 0.0002). Prospectively, the risk of symptomatic hemorrhage was 4.2% for RICMs and 2.3% for nonradiation CMs per person-year (p = 0.556). In the absence of symptoms at presentation, the risk of hemorrhage for RICMs was higher than for nonradiation CMs (4.2% vs 0.35%, respectively; p = 0.118). In this patient population, RICMs occurred within the radiation port approximately 12 years after radiation treatment. Compared with nonradiation CMs, RICMs were more likely to occur as multiple CMs, to present at a younger age, and were at least as likely to cause symptomatic hemorrhage.

  12. Endovascular treat- ment of post- traumatic carotid- cavernous ...

    African Journals Online (AJOL)

    Kurt

    Types B, C and D are all indirect. (or dural) fistulae. The angioarchitec- ture of these is analogous to dural arteriovenous fistulae (AVFs) occur- ... penetrating trauma, ruptured intra- cavernous carotid aneurysms, colla- gen deficiency syndromes (such as. Ehlers-Danlos IV syndrome), fibro- muscular dysplasia and arterial dis-.

  13. Lowering End-cap YE-1 in the CMS cavern

    CERN Document Server

    2008-01-01

    On Tuesday 22 January, the dance of the CMS end-caps came to an end with the lowering of YE-1, the heaviest of them all. After a spectacular lowering operation lsting ten hours, this mammoth component completed the 100-metre descent and was gently placed on the floor of the CMS cavern to the applause of the many onlookers.

  14. NA62 cavern and sub-detectors 2017

    CERN Multimedia

    Graham, Connor

    2017-01-01

    The NA62 cavern, with the completed detector, during breaks in data taking in July 2017. Pictures from 05-07-17 by Dan Protopopescu and pictures from 08-07-17 by Connor Graham (Both Glasgow-affiliated). Includes pictures of the whole experiment, safety systems and sub-detector elements.

  15. Hepatic cavernous hemangioma in cirrhotic liver: imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Jeong Sik; Kim, Ki Whang; Park, Mi Suk; Yoon, Sang Wook [College of Medicine, Yonsei University, Seoul (Korea, Republic of)

    2000-12-01

    To document the imaging findings of hepatic cavernous hemangioma detected in cirrhotic liver. The imaging findings of 14 hepatic cavernous hemangiomas in ten patients with liver cirrhosis were retrospectively analyzed. A diagnosis of hepatic cavernous hemangioma was based on the findings of two or more of the following imaging studies: MR, including contrast-enhanced dynamic imaging (n=10), dynamic CT (n=4), hepatic arteriography (n=9), and US (n=10). The mean size of the 14 hepatic hemangioma was 0.9 (range, 0.5-1.5) cm in the longest dimension. In 11 of these (79%), contrast-enhanced dynamic CT and MR imaging showed rapid contrast enhancement of the entire lesion during the early phase, and hepatic arteriography revealed globular enhancement and rapid filling-in. On contrast-enhanced MR images, three lesions (21%) showed partial enhancement until the 5-min delayed phases. US indicated that while three slowly enhancing lesions were homogeneously hyperechoic, 9 (82%) of 11 showing rapid enhancement were not delineated. The majority of hepatic cavernous hemangiomas detected in cirrhotic liver are small in size, and in many, hepatic arteriography and/or contrast-enhanced dynamic CT and MR imaging demonstrates rapid enhancement. US, however, fails to distinguish a lesion of this kind from its cirrhotic background. (author)

  16. A Numerical Study of Underground Cavern Stability by Geostress Characteristics

    Directory of Open Access Journals (Sweden)

    Xiao-Jing Li

    2016-01-01

    Full Text Available The stability of underground cavities is of increasing importance considering the predominant cavity locations built up in high mountain and canyon environments. Such cavity locations are characterized by a high initial in situ stress, which results in brittle fracture and deformation of the surrounding rock during cavity construction. This paper presents a numerical study of underground cavern stability considering four factors, namely, mechanical property of surrounding rock, cavern burial depth, lateral pressure coefficient in horizontal direction, and the angle included between plant longitudinal axis and horizontal principal stress. Analytical methods including the key point displacement in side wall, plastic zone volume, and splitting fracture volume are used to characterize the stability of underground cavern. A modified formula to predict side wall displacement is proposed based on prior work, which is applicable to 3D computation model by taking horizontal geostress in two directions into account. Eventually, the optimal layout of underground cavern is put forward under different conditions of geostress field.

  17. Analysis of SPR salt cavern remedial leach program 2013.

    Energy Technology Data Exchange (ETDEWEB)

    Weber, Paula D.; Gutierrez, Karen A.; Lord, David L.; Rudeen, David Keith

    2013-09-01

    The storage caverns of the US Strategic Petroleum Reserve (SPR) exhibit creep behavior resulting in reduction of storage capacity over time. Maintenance of oil storage capacity requires periodic controlled leaching named remedial leach. The 30 MMB sale in summer 2011 provided space available to facilitate leaching operations. The objective of this report is to present the results and analyses of remedial leach activity at the SPR following the 2011 sale until mid-January 2013. This report focuses on caverns BH101, BH104, WH105 and WH106. Three of the four hanging strings were damaged resulting in deviations from normal leach patterns; however, the deviations did not affect the immediate geomechanical stability of the caverns. Significant leaching occurred in the toes of the caverns likely decreasing the number of available drawdowns until P/D ratio criteria are met. SANSMIC shows good agreement with sonar data and reasonably predicted the location and size of the enhanced leaching region resulting from string breakage.

  18. A Case of Brainstem Cavernous Angioma Presenting with Persistent Hiccups

    Directory of Open Access Journals (Sweden)

    Mohammad Ali Arami

    2010-08-01

    Full Text Available Intractable hiccup most be considered as a symptom of underlying serious pathologies. We report a case of medulla oblongata cavernous angima presented with persistant hiccup and without any improvement during routine nonpharmacologic and pharmacologic treatment regimns. The patient is under our follow up visits and surgery is very high risk for this young girl.

  19. Indocyanine green videoangiography of optic cavernous angioma - case report - .

    Science.gov (United States)

    Murai, Yasuo; Adachi, Koji; Koketsu, Kenta; Teramoto, Akira

    2011-01-01

    The intraoperative findings of an indocyanine green videoangiography (ICG-VAG) study of a cavernous angioma located in the optic chiasm are reported. A 23-year-old Japanese man suddenly developed visual field loss, and magnetic resonance imaging suggested the presence of a suprasellar tumor in contact with the optic chiasm. Preoperative angiography did not clearly show any tumor shadow. Right fronto-temporal craniotomy was performed, and an aggregation of blood vessels was seen on the right surface of the optic chiasm. Cavernous angioma was suspected. ICG-VAG was begun 22 seconds after the beginning of contrast agent infusion via a peripheral blood vessel. The lesion remained unstained, although the brain surface, an artery superior to the optic nerve, and veins were visualized. The cavernous angioma was resected following surface coagulation. ICG-VAG is currently being evaluated for future application in the differential diagnosis based on imaging findings, and the present case provides an important example of intraoperative ICG-VAG imaging of an unoperated cavernous angioma.

  20. Trigonal cavernous angioma presenting with selective ventricular exclusion.

    Science.gov (United States)

    Prada, F; Saladino, A; Giombini, S

    2010-12-01

    We present a case of a patient with an intraventricular cavernous angioma originating from the splenium of the corpus callosum presenting with intracranial hypertension syndrome. In our case the growth of the lesion from the corpus callosum toward the ventricular spaces determined the direct exclusion of the occipital and temporal horn of the left lateral ventricle.

  1. Endothelial TLR4 and the microbiome drive cerebral cavernous malformations

    NARCIS (Netherlands)

    Tang, Alan T.; Hoi, Jaesung P. C.; Kotzin, Jonathan J.; Yang, Yiqing; Hong, Courtney C.; Hobson, Nicholas; Girard, Romuald; Zeineddine, Hussein A.; Lightle, Rhonda; Moore, Thomas; Cao, Ying; Shenkar, Robert; Chen, Mei; Mericko, Patricia; Yang, Jisheng; Li, Li; Tanes, Ceylan; Kobuley, Dmytro; Vosa, Urmo; Whitehead, Kevin J.; Li, Dean Y.; Franke, Lude; Hart, Blaine; Schwaninger, Markus; Henao-Mejia, Jorge; Morrison, Leslie; Kim, Helen; Awad, Issam A.; Zheng, Xiangjian; Kahn, Mark L.

    2017-01-01

    Cerebral cavernous malformations (CCMs) are a cause of stroke and seizure for which no effective medical therapies yet exist. CCMs arise from the loss of an adaptor complex that negatively regulates MEKK3-KLF2/4 signalling in brain endothelial cells, but upstream activators of this disease pathway

  2. A Case of Brainstem Cavernous Angioma Presenting with Persistent Hiccups

    Directory of Open Access Journals (Sweden)

    Mohammad Ali Arami

    2010-07-01

    Full Text Available "nIntractable hiccup most be considered as a symptom of underlying serious pathologies. We report a case of medulla oblongata cavernous angima presented with persistant hiccup and without any improvement during routine nonpharmacologic and pharmacologic treatment regimns. The patient is under our follow up visits and surgery is very high risk for this young girl.

  3. Urethral cavernous hemangioma in a female patient: a rare entity ...

    African Journals Online (AJOL)

    Genitourinary hemangiomas are rare entities of the urinary system. We reported a female patient who suffered dyspareunia and intermitant hematuria that was proved as urethral cavernous hemangioma. Despite its benign nature, hemangiomas may recur due to incomplet excision. Pan African Medical Journal 2015; 22 ...

  4. Soft tissue cavernous haemangioma: Photo essay | Girma | Journal ...

    African Journals Online (AJOL)

    Soft tissue cavernous haemangioma: Photo essay. Edom Girma, Asfaw Atnafu. http://dx.doi.org/10.4314/jemp.v4i1.10614 · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL · News.

  5. Congenital cerebral cavernous malformations in an infant: A case report

    Directory of Open Access Journals (Sweden)

    Jennifer L. Quon

    2014-12-01

    Full Text Available Abusive head trauma is a leading cause of infant death, but other causes of intracranial hemorrhage must be systematically excluded. Here we present a case of multiple hemorrhagic cavernous malformations that was initially thought to be indicative of abusive head trauma. Using a clinical decision-making framework, we provide insight into child abuse diagnostics.

  6. Congenital cerebral cavernous malformations in an infant: A case report

    OpenAIRE

    Quon, Jennifer L.; Grant, Ryan A.; Asnes, Andrea G.; DiLuna, Michael L

    2014-01-01

    Abusive head trauma is a leading cause of infant death, but other causes of intracranial hemorrhage must be systematically excluded. Here we present a case of multiple hemorrhagic cavernous malformations that was initially thought to be indicative of abusive head trauma. Using a clinical decision-making framework, we provide insight into child abuse diagnostics.

  7. Traumatic carotid-cavernous fistula presenting as massive epistaxis.

    Science.gov (United States)

    Wyrick, Deidre; Smith, Samuel D; Dassinger, Melvin S

    2013-04-01

    Carotid-cavernous sinus fistulae (CCF) are a rare complication with the potential for great morbidity including intracranial hemorrhage, blindness, cranial nerve palsy and stroke. Traumatic CCF are the most common type of CCF. Here we discuss a patient who sustained blunt head trauma and had substantial epistaxis, requiring massive transfusion, intraoperatively due to unrecognized CCF. Copyright © 2013 Elsevier Inc. All rights reserved.

  8. Novel Evidence-Based Classification of Cavernous Venous Occlusive Disease.

    Science.gov (United States)

    Pathak, Ram A; Rawal, Bhupendra; Li, Zhuo; Broderick, Gregory A

    2016-10-01

    The primary aim of our study was to determine whether an evidence-based rationale could categorize cavernous venous occlusive disease into mild, moderate and severe erectile dysfunction. A total of 863 patients underwent color duplex Doppler ultrasound from January 2010 to June 2013 performed by a single urologist. We identified a cohort of 75 patients (8.7%) with a diagnosis of cavernous venous occlusive disease based on a unilateral resistive index less than 0.9, and right and left peak systolic velocity 35 cm per second or less after visual sexual stimulation. At a median followup of 13 months patients were evaluated for treatment efficacy. A total of 75 patients with a median age of 60 years (range 19 to 83) and a mean body mass index of 26.3 kg/m(2) (range 19.0 to 39.3) satisfied the criteria of cavernous venous occlusive disease. When substratified into tertiles, resistive index cutoffs were obtained, including mild cavernous venous occlusive disease-81.6 to 94.0, moderate disease-72.6 to 81.5 and severe disease-59.5 to 72.5. Using these 3 groups the phosphodiesterase type 5-inhibitor failure rate (p = 0.017) and SHIM (Sexual Health Inventory for Men) score categories (1 to 10 vs 11 to 20, p = 0.030) were statistically significantly different for mild, moderate and severe cavernous venous occlusive disease. Treatment satisfaction was also statistically significantly different. Penile prosthetic placement was a more common outcome among patients with erectile dysfunction and more severe cavernous venous occlusive disease. Our retrospective analysis supports a correlation between the phosphodiesterase type 5 inhibitor failure rate, SHIM score and the rate of surgical intervention using resistive index values. Our data further suggest that an evidence-based classification of cavernous venous occlusive disease by color Doppler ultrasound is possible and can triage patients to penile prosthetic placement. Copyright © 2016 American Urological Association

  9. Discovery Mondays: 'The civil engineering genius of the 100-metre deep underground caverns'

    CERN Multimedia

    2004-01-01

    CERN is first and foremost a place where physicists study particle collisions. But to be able to observe the infinitely small, they need huge pieces of equipment, the accelerators and detectors, whose construction, some 100 metres below the earth's surface calls on the services of other fascinating disciplines. Take civil engineering, for example. For the construction of the LHC some 420 000 cubic metres of rock have had to be excavated for the 6500 metres of tunnel, 6 new shafts and 32 underground chambers and caverns. To avoid disrupting other experiments in progress, the work on these exceptional structures has had to be done without creating vibrations. The ATLAS experiment hall, a huge cathedral-like structure 100 metres below ground, is another mind-blowing feat of civil engineering. Its construction involved the use of ground-breaking technology, such as the system for suspending the ceiling put in place during the excavation work. At the next Discovery Monday, the specialists responsible for...

  10. Ultrastructural changes of penile cavernous tissue in multiple sclerotic rats.

    Science.gov (United States)

    Jiang, Jun; He, Yanzheng; Jiang, Rui

    2009-08-01

    Multiple sclerosis (MS) is one of the important risk factors resulting in erectile dysfunction (ED). The ultrastructure of corpus cavernous of the penis have an important role in the mechanism of erection. It is suggested that different medical conditions produce similar degenerative tissue responses. We investigated the ultrastructural changes of penile cavernous tissue and its association with ED in multiple sclerotic rats. After induction of multiple sclerosis in rat, maximum intracavernosal pressure/mean arterial pressure (ICP(max)/MAP) in the severity multiple sclerotic rats (group A),moderate multiple sclerotic rats (group C), and age-matched control rat (group B) were observed and compared. The ultrastructure of the penile cavernous tissue was studied by transmission electron microscope. Expression of neuronal nitric oxide synthase (nNOS) in penile tissue were examined immunohistochemically. Severity MS (score 3) not only significantly decrease the ICPmax/MAP x 100 and the expression of nNOS, but also might affect the ultrastructure of the penis. The ICP(max)/MAP x 100 in group A was significantly less than in group B and group C at 3 V (5.65 +/- 1.78, 20.49 +/- 5.84, and 12.78 +/- 5.76, respectively) and at 5 V (6.70 +/- 1.39, 23.66 +/- 5.19, and 16.95 +/- 3.31, respectively) stimulation voltage, respectively (P cavernous tissue of group A rats. The function of penile erection is affected by MS, and the ultrastructural pathological changes of the penile cavernous tissue may be one of the important mechanisms of ED caused by severity MS.

  11. Endoscopic supraorbital extradural approach to the cavernous sinus: a cadaver study.

    Science.gov (United States)

    Komatsu, Fuminari; Komatsu, Mika; Inoue, Tooru; Tschabitscher, Manfred

    2011-05-01

    The cavernous sinus is a small complex structure located at the central base of the skull. Recent extensive use of endoscopy has provided less invasive approaches to the cavernous sinus via endonasal routes, although transcranial routes play an important role in the approach to the cavernous sinus. The aims of this study were to evaluate the feasibility of the purely endoscopic transcranial approach to the cavernous sinus through the supraorbital keyhole and to better understand the distorted anatomy of the cavernous sinus via endoscopy. Eight fresh cadavers were studied using 4-mm 0° and 30° endoscopes to develop a surgical approach and to identify surgical landmarks. The endoscopic supraorbital extradural approach was divided into 4 stages: entry into the extradural anterior cranial fossa, exposure of the middle cranial fossa and the periorbita, exposure of the superior cavernous sinus, and exposure of the lateral cavernous sinus. This approach provided superb views of the cavernous sinus structures, especially through the clinoidal (Dolenc) triangle. The lateral wall of the cavernous sinus, including the infratrochlear (Parkinson) triangle and anteromedial (Mullan) triangle, was also clearly demonstrated. An endoscopic supraorbital extradural approach offers excellent exposure of the superior and lateral walls of the cavernous sinus with minimal invasiveness via the transcranial route. This approach could be an alternative to the conventional transcranial approach.

  12. Celebration for the ATLAS Barrel Toroid magnet

    CERN Multimedia

    2007-01-01

    Representatives from Funding Agencies and Barrel Toroid Magnet Laboratories during the ceremony. From left to right: Jean Zinn-Justin (Head of DAPNIA/CEA/Saclay), CERN Director-General Robert Aymar, and Roberto Petronzio (President INFN).Allan Clark (DPNC University Geneva) and Enrique Fernandez (IFAE Barcelona) were among the guests visiting the ATLAS cavern. The barrel toroid is visible in the background. A celebration took place at Point 1 on 13 December to toast the recent powering-up of the ATLAS barrel toroid magnet to full field (Bulletin No. 47-48/06). About 70 guests were invited to attend, mainly composed of representatives from funding partners and key members of the laboratory management teams of the barrel toroid magnet, representing CEA France, INFN Italy, BMBF Germany, Spain, Sweden, Switzerland, Russia, JINR Dubna and CERN. An introductory speech by ATLAS spokesperson Peter Jenni the scene for evening. This was followed by the ATLAS magnet system project leader Herman Ten Kate's account of the...

  13. A Time for Atlases and Atlases for Time

    Science.gov (United States)

    Livneh, Yoav; Mizrahi, Adi

    2009-01-01

    Advances in neuroanatomy and computational power are leading to the construction of new digital brain atlases. Atlases are rising as indispensable tools for comparing anatomical data as well as being stimulators of new hypotheses and experimental designs. Brain atlases describe nervous systems which are inherently plastic and variable. Thus, the levels of brain plasticity and stereotypy would be important to evaluate as limiting factors in the context of static brain atlases. In this review, we discuss the extent of structural changes which neurons undergo over time, and how these changes would impact the static nature of atlases. We describe the anatomical stereotypy between neurons of the same type, highlighting the differences between invertebrates and vertebrates. We review some recent experimental advances in our understanding of anatomical dynamics in adult neural circuits, and how these are modulated by the organism's experience. In this respect, we discuss some analogies between brain atlases and the sequenced genome and the emerging epigenome. We argue that variability and plasticity of neurons are substantially high, and should thus be considered as integral features of high-resolution digital brain atlases. PMID:20204142

  14. A time for atlases and atlases for time

    Directory of Open Access Journals (Sweden)

    Yoav Livneh

    2010-02-01

    Full Text Available Advances in neuroanatomy and computational power are leading to the construction of new digital brain atlases. Atlases are rising as indispensable tools for comparing anatomical data as well as being stimulators of new hypotheses and experimental designs. Brain atlases describe nervous systems which are inherently plastic and variable. Thus, the levels of brain plasticity and stereotypy would be important to evaluate as limiting factors in the context of static brain atlases. In this review, we discuss the extent of structural changes which neurons undergo over time, and how these changes would impact the static nature of atlases. We describe the anatomical stereotypy between neurons of the same type, highlighting the differences between invertebrates and vertebrates. We review some recent experimental advances in our understanding of anatomical dynamics in adult neural circuits, and how these are modulated by the organism’s experience. In this respect, we discuss some analogies between brain atlases and the sequenced genome and the emerging epigenome. We argue that variability and plasticity of neurons are substantially high, and should thus be considered as integral features of high-resolution digital brain atlases.

  15. T.D Lee and Lisa Randall visit ATLAS

    CERN Multimedia

    Pauline Gagnon

    Professor Tsung-Dao Lee, who received the Nobel Prize for Physics in 1957 for postulating that parity is not conserved in weak interactions, visited the ATLAS detector this month. He is seen here in the company of Peter Jenni, spokesperson for ATLAS. T.D. Lee is still very active at over 80, pursuing his theory work to this day. Professor Lisa Randall from Harvard University, the well-known theorist behind the Randall-Sundrum theory for extra dimensions, was also part of the group visiting the ATLAS detector. She is seen here with Fabiola Gianotti, deputy spokesperson for ATLAS. Lisa Randall's two initial papers have been quoted both more than 2500 times, making her the most cited theoretical physicist in the world in the last five years as of last autumn - a total of about 10,000 citations! One wonders here if Peter is pointing to a CP-violating graviton spotted in the ATLAS cavern... From left to right: Fabiola Gianotti, Gustaaf Brooijmans, convener of the ATLAS Exotics physics gro...

  16. Sensitivity of storage field performance to geologic and cavern design parameters in salt domes.

    Energy Technology Data Exchange (ETDEWEB)

    Ehgartner, Brian L. (Sandia National Laboratories, Albuquerque, NM); Park, Byoung Yoon

    2009-03-01

    A sensitivity study was performed utilizing a three dimensional finite element model to assess allowable cavern field sizes for strategic petroleum reserve salt domes. A potential exists for tensile fracturing and dilatancy damage to salt that can compromise the integrity of a cavern field in situations where high extraction ratios exist. The effects of salt creep rate, depth of salt dome top, dome size, caprock thickness, elastic moduli of caprock and surrounding rock, lateral stress ratio of surrounding rock, cavern size, depth of cavern, and number of caverns are examined numerically. As a result, a correlation table between the parameters and the impact on the performance of storage field was established. In general, slower salt creep rates, deeper depth of salt dome top, larger elastic moduli of caprock and surrounding rock, and a smaller radius of cavern are better for structural performance of the salt dome.

  17. Histotopography of the female cavernous nerve: a study using donated fetuses and adult cadavers.

    Science.gov (United States)

    Kato, Masao; Niikura, Hitoshi; Yaegashi, Nobuo; Murakami, Gen; Tatsumi, Haruyuki; Matsubara, Akio

    2008-12-01

    The purpose of this study was to identify the histotopography of the female cavernous nerve. The study used semi-serial horizontal sections of seven fetuses and ten adult cadavers. In fetuses, the female cavernous nerve ran anteriorly between the distal vagina and the levator ani and entered the corpus cavernosum clitoridis. Its course through the argental hiatus was similar to that of the male cavernous nerve. However, the fascial arrangement along the female cavernous nerve was different from that of the three male fetuses included in this study. In female adults, the putative cavernous nerve was found running along the lateral aspect of the rhabdosphincter, along the superior surface of the urethrovaginal sphincter and around the lateral end of the latter sphincter. Because the female cavernous nerve and lateral vaginal wall are closely related, surgical treatment along the mid- and distal urethra should be conducted cautiously so as not to injure the perivaginal autonomic nerves.

  18. The new European wind atlas

    DEFF Research Database (Denmark)

    Lundtang Petersen, Erik; Troen, Ib; Ejsing Jørgensen, Hans

    2014-01-01

    European Wind Atlas” aiming at reducing overall uncertainties in determining wind conditions; standing on three legs: A data bank from a series of intensive measuring campaigns; a thorough examination and redesign of the model chain from global, mesoscale to microscale models and creation of the wind atlas...... database. Although the project participants will come from the 27 member states it is envisioned that the project will be opened for global participation through test benches for model development and sharing of data – climatologically as well as experimental. Experiences from national wind atlases...... will be utilized, such as the Indian, the South African, the Finnish, the German, the Canadian atlases and others....

  19. Demonstrated rapid growth of a corpus callosum cavernous angioma within a short period of time.

    Science.gov (United States)

    Ozer, E; Yücesoy, K; Kalemci, O

    2005-12-01

    Cavernous angiomas are uncommon central nervous system vascular malformations. They occur in the corpus callosum very rarely. In this study we report a case of corpus callosum cavernous angioma which demonstrated rapid growth within a short period of time. Corpus callosum cavernous angiomas have distinct features regarding growth and should be treated more carefully by giving more importance to surgical removal rather than a conservative approach.

  20. Event visualization in ATLAS

    Science.gov (United States)

    Bianchi, R. M.; Boudreau, J.; Konstantinidis, N.; Martyniuk, A. C.; Moyse, E.; Thomas, J.; Waugh, B. M.; Yallup, D. P.; ATLAS Collaboration

    2017-10-01

    At the beginning, HEP experiments made use of photographical images both to record and store experimental data and to illustrate their findings. Then the experiments evolved and needed to find ways to visualize their data. With the availability of computer graphics, software packages to display event data and the detector geometry started to be developed. Here, an overview of the usage of event display tools in HEP is presented. Then the case of the ATLAS experiment is considered in more detail and two widely used event display packages are presented, Atlantis and VP1, focusing on the software technologies they employ, as well as their strengths, differences and their usage in the experiment: from physics analysis to detector development, and from online monitoring to outreach and communication. Towards the end, the other ATLAS visualization tools will be briefly presented as well. Future development plans and improvements in the ATLAS event display packages will also be discussed.

  1. Event visualization in ATLAS

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00211497; The ATLAS collaboration; Boudreau, Joseph; Konstantinidis, Nikolaos; Martyniuk, Alex; Moyse, Edward; Thomas, Juergen; Waugh, Ben; Yallup, David

    2017-01-01

    At the beginning, HEP experiments made use of photographical images both to record and store experimental data and to illustrate their findings. Then the experiments evolved and needed to find ways to visualize their data. With the availability of computer graphics, software packages to display event data and the detector geometry started to be developed. Here, an overview of the usage of event display tools in HEP is presented. Then the case of the ATLAS experiment is considered in more detail and two widely used event display packages are presented, Atlantis and VP1, focusing on the software technologies they employ, as well as their strengths, differences and their usage in the experiment: from physics analysis to detector development, and from online monitoring to outreach and communication. Towards the end, the other ATLAS visualization tools will be briefly presented as well. Future development plans and improvements in the ATLAS event display packages will also be discussed.

  2. Ruptured Persistent Trigeminal Artery Causing Direct Cavernous Sinus Fistula Treated with Pipeline Embolization and Minimal Coiling.

    Science.gov (United States)

    Yoon, Nam K; Awad, Al-Wala; Gee, James M; Taussky, Philipp

    2018-01-01

    Rupture of a persistent trigeminal artery associated with development of a cavernous sinus fistula in a traumatic setting is rare. These arteries are typically treated with coil embolization of the cavernous sinus. We present the case of a 42-year-old woman who developed a direct cavernous carotid fistula after a motor vehicle accident. Angiographic imaging revealed a rupture point of a persistent trigeminal artery as it connected with the cavernous segment of the internal carotid artery, causing a cavernous sinus fistula. Coiling of the cavernous sinus was abandoned after placement of 1 coil because of coil herniation into the internal carotid artery. A Pipeline embolization device was placed to oppose the coil against the intima and keep the lumen open. The combination of coil embolization and flow diversion acutely decreased the fistulous flow. Surprisingly, an angiographic follow-up at 6 months showed complete fistula occlusion despite placement of only 1 coil into the cavernous sinus. We report a rare case where undercoiling of the cavernous sinus occluded a cavernous sinus fistula because of the adjunct use of a Pipeline embolization device in the presence of a traumatic rupture of a persistent trigeminal artery. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. STORAGE OF CHILLED NATURAL GAS IN BEDDED SALT STORAGE CAVERNS

    Energy Technology Data Exchange (ETDEWEB)

    JOel D. Dieland; Kirby D. Mellegard

    2001-11-01

    This report provides the results of a two-phase study that examines the economic and technical feasibility of converting a conventional natural gas storage facility in bedded salt into a refrigerated natural gas storage facility for the purpose of increasing the working gas capacity of the facility. The conceptual design used to evaluate this conversion is based on the design that was developed for the planned Avoca facility in Steuben County, New York. By decreasing the cavern storage temperature from 43 C to -29 C (110 F to -20 F), the working gas capacity of the facility can be increased by about 70 percent (from 1.2 x 10{sup 8} Nm{sup 3} or 4.4 billion cubic feet (Bcf) to 2.0 x 10{sup 8} Nm{sup 3} or 7.5 Bcf) while maintaining the original design minimum and maximum cavern pressures. In Phase I of the study, laboratory tests were conducted to determine the thermal conductivity of salt at low temperatures. Finite element heat transfer calculations were then made to determine the refrigeration loads required to maintain the caverns at a temperature of -29 C (-20 F). This was followed by a preliminary equipment design and a cost analysis for the converted facility. The capital cost of additional equipment and its installation required for refrigerated storage is estimated to be about $13,310,000 or $160 per thousand Nm{sup 3} ($4.29 per thousand cubic feet (Mcf)) of additional working gas capacity. The additional operating costs include maintenance refrigeration costs to maintain the cavern at -29 C (-20 F) and processing costs to condition the gas during injection and withdrawal. The maintenance refrigeration cost, based on the current energy cost of about $13.65 per megawatt-hour (MW-hr) ($4 per million British thermal units (MMBtu)), is expected to be about $316,000 after the first year and to decrease as the rock surrounding the cavern is cooled. After 10 years, the cost of maintenance refrigeration based on the $13.65 per MW-hr ($4 per MMBtu) energy cost is

  4. [Therapeutic effect of gamma knife on intracranial cavernous angioma].

    Science.gov (United States)

    Jia, Ge; Zhang, Junmei; Ma, Zhiming; Qiu, Bin; Hou, Yonghong

    2014-12-01

    To evaluate the therapeutic effect of gamma knife on patients with intracranial cavernous angioma (CA). The medical records of 122 patients (134 lesions) who underwent radiosurgery were reviewed retrospectively. Th e average follow-up period was 43 months. No patient died. One patient underwent CA resection. In patients with epilepsy, 83% patients showed alleviation of seizures. About 44% of the lesions shrank in size after treatment with gamma knife radiosurgery (59/134). Seven cases had hemorrhage again after radiosurgery, and the overall annual hemorrhage rate was 1.6%. Edema was found in 11.5% patients (14/122) and all patients showed improvement aft er treatment. Gamma knife is a safe treatment for CA, which could obviously improve the symptoms of epilepsy. Gamma knife radiosurgery is the fi rst option for the treatment of cavernous sinus angiomas.

  5. Surgical treatment of large and giant cavernous carotid aneurysms

    Science.gov (United States)

    Sriamornrattanakul, Kitiporn; Sakarunchai, Ittichai; Yamashiro, Kei; Yamada, Yasuhiro; Suyama, Daisuke; Kawase, Tsukasa; Kato, Yoko

    2017-01-01

    Cavernous carotid aneurysms (CCAs) are uncommon pathologic entities. Extradural place and the skull base location make this type of an aneurysm different in clinical features and treatment techniques. Direct aneurysm clipping is technically difficult and results in a significant postoperative neurological deficit. Therefore, several techniques of indirect surgical treatment were developed with different surgical outcomes, such as proximal occlusion of internal carotid artery (ICA) or trapping with or without bypass (superficial temporal artery-middle cerebral artery bypass or high-flow bypass). High-flow bypass with proximal ICA occlusion seems to be the most appropriate surgical treatment for CCA because of the high rate of symptom improvement, aneurysm thrombosis, and minimal postoperative complications. However, in cases of CCA presented with direct carotid-cavernous fistula, the appropriate surgical treatment is high-flow bypass with aneurysm trapping, which the fistula can be obliterated immediately after surgery. PMID:28761512

  6. Cluster Headache Secondary to Macroprolactinoma with Ipsilateral Cavernous Sinus Invasion

    Directory of Open Access Journals (Sweden)

    M. J. Levy

    2012-01-01

    Full Text Available We present a 25 year-old man with episodic cluster headache that was refractory to all standard pharmacological prophylactic and abortive treatments. Because of the lack of response, an MRI brain was performed which showed a large pituitary tumour with ipsilateral cavernous sinus invasion. The serum prolactin was significantly elevated at 54,700 miU/L (50–400 confirming a macro-prolactinoma. Within a few days of cabergoline therapy the headache resolved. He continues to be headache free several years after starting the dopamine agonist. This case highlights the importance of imaging the pituitary fossa in patients with refractory cluster headache, It also raises the potential anatomical importance of the cavernous sinus in pituitary-associated headache.

  7. Adult primary retroperitoneal cavernous hemangioma: a case report

    Directory of Open Access Journals (Sweden)

    He Hang

    2012-12-01

    Full Text Available Abstract Primary retroperitoneal cavernous hemangioma (PRCH in an adult is extremely rare. We report on the diagnosis and treatment of a patient with PRCH with subtle clinical features and atypical findings on imaging scans. A 38-year-old man was admitted to hospital with a 5-day history of epigastralgia after alcohol drinking. Using various imaging methods, we found a giant cyst-like retroperitoneal mass compressing the surrounding organs. Surgical resection of the tumor was performed, and the mass was found to be a cavernous hemangioma measuring 90 × 80 × 60 mm, with a thick fibrotic wall and extensive intracystic hemorrhage. Physicians should be aware that PRCH may mimic a cystic neoplasm, and that a large tumor size probably indicates intracystic hemorrhage. Surgical resection is a curative approach for PRCH.

  8. Novel image analysis of corpus cavernous tissue in impotent men.

    Science.gov (United States)

    Lin, J S; Lin, Y M; Chow, N H; Wang, S T; Sun, Y N

    2000-02-01

    To objectively evaluate the contents of corpus cavernous tissue in impotent men using an automated novel image analysis system. Thirty-three impotent men and 2 normal potent men (controls) underwent corpus cavernous biopsies. The procedures were performed using a Biopty gun under local anesthesia. The obtained specimens were stained with Masson's trichome technique, and the collagen fiber contents were evaluated by a computerized morphometric analysis method. In addition, we estimated the intraobserver and interobserver reliability of this automated image analysis system. No major complication was noted during or after the biopsies. Of the 33 impotent patients, 3 were diagnosed as having psychogenic, 11 as having arteriogenic, 13 as having venogenic, 1 as having neurogenic, and 5 as having idiopathic impotence. The collagen fiber percentages in the 35 men were as follows: normal potent: 48.2% +/- 1.4%, psychogenic 55.2% +/- 11.6%, arteriogenic 73.2% +/- 4.4%, venogenic 66.5% +/- 4.2%, neurogenic 76.9%, and idiopathic 77.4% +/- 4.2%. Significant differences were found between the normal potent and arteriogenic groups (P image analysis system. This method significantly reduced the amount of variation introduced by the intra-rater reliability of a technician compared with the manual method. The present automated image analysis system is believed to be a reliable, accurate quantitative measurement tool for studies of penile tissue. Cavernous biopsy is a rapid, safe, and representative modality to study penile disease. An increase in cavernous collagen fibers (or corporal fibrosis) is considered an important factor in impaired erectile function.

  9. Cavernous Hemangioma of the Rib: A Rare Diagnosis

    Directory of Open Access Journals (Sweden)

    Stavros Gourgiotis

    2010-01-01

    Full Text Available Hemangioma of the rib is an uncommon benign vascular tumour. A case of rib hemangioma in a 29-year-old woman is presented. Chest roentgenogram and computed tomography revealed a mass along the inner surface of the 7th left rib with bone destruction. She underwent resection of the 7th rib. The pathologic diagnosis was cavernous hemangioma. Hemangiomas of the rib are rare tumours but should be kept in mind in the differential diagnosis of rib tumours.

  10. Cavernous lymph angioma of the ileal mesentery; A case report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Joung Sook; Chang, Young Woong; Koo, Chul Hoe [Chun Cheon Medical Center, Chuncheon (Korea, Republic of)

    1989-06-15

    Lymph angiomas are benign tumors of the lymphatic vessels and classified into three kinds; simple, cavenous and cystic type. They occur mainly in children, most commonly as cystic hygromas in the neck but rarely in the abdominal cavity as lymph angiomas in the mesentery and small intestine. We have experienced an unusual case of cavernous lymph angioma of ileal mesentery demonstrated chiefly as solid mass in ultrasonography and CT and report the case briefly with reviewing the literature.

  11. Cavernous Angioma of the Corpus Callosum Presenting with Acute Psychosis

    OpenAIRE

    Giacomo Pavesi; Francesco Causin; Alberto Feletti

    2014-01-01

    Psychiatric symptoms may occasionally be related to anatomic alterations of brain structures. Particularly, corpus callosum lesions seem to play a role in the change of patients’ behavior. We present a case of a sudden psychotic attack presumably due to a hemorrhagic cavernous angioma of the corpus callosum, which was surgically removed with complete resolution of symptoms. Although a developmental defect like agenesis or lipoma is present in the majority of these cases, a growing lesion of t...

  12. Configuration of Fibrous and Adipose Tissues in the Cavernous Sinus

    Science.gov (United States)

    Liang, Liang; Gao, Fei; Xu, Qunyuan; Zhang, Ming

    2014-01-01

    Objective Three-dimensional anatomical appreciation of the matrix of the cavernous sinus is one of the crucial necessities for a better understanding of tissue patterning and various disorders in the sinus. The purpose of this study was to reveal configuration of fibrous and adipose components in the cavernous sinus and their relationship with the cranial nerves and vessels in the sinus and meningeal sinus wall. Materials and Methods Nineteen cadavers (8 females and 11 males; age range, 54–89 years; mean age, 75 years) were prepared as transverse (6 sets), coronal (3 sets) and sagittal (10 sets) plastinated sections that were examined at both macroscopic and microscopic levels. Results Two types of the web-like fibrous networks were identified and localized in the cavernous sinus. A dural trabecular network constituted a skeleton-frame in the sinus and contributed to the sleeves of intracavernous cranial nerves III, IV, V1, V2 and VI. A fine trabecular network, or adipose tissue, was the matrix of the sinus and was mainly distributed along the medial side of the intracavernous cranial nerves, forming a dumbbell-shaped adipose zone in the sinus. Conclusions This study revealed the nature, fine architecture and localization of the fine and dural trabecular networks in the cavernous sinus and their relationship with intracavernous cranial nerves and vessels. The results may be valuable for better understanding of tissue patterning in the cranial base and better evaluation of intracavernous disorders, e.g. the growth direction and extent of intracavernous tumors. PMID:24586578

  13. Relative Evaluation of the Independent Volume Measures of Caverns

    Energy Technology Data Exchange (ETDEWEB)

    MUNSON,DARRELL E.

    2000-08-01

    Throughout the construction and operation of the caverns of the Strategic Petroleum Reserve (SPR), three types of cavern volume measurements have been maintained. These are: (1) the calculated solution volume determined during initial construction by solution mining and any subsequent solutioning during oil transfers, (2) the calculated sonar volume determined through sonar surveys of the cavern dimensions, and (3) the direct metering of oil to determine the volume of the cavern occupied by the oil. The objective of this study is to compare these measurements to each other and determine, if possible, the uncertainties associated with a given type of measurement. Over time, each type of measurement has acquired a customary, or an industry accepted, stated uncertainty. This uncertainty is not necessarily the result of a technical analysis. Ultimately there is one definitive quantity, the oil volume measure by the oil custody transfer meters, taken by all parties to the transfer as the correct ledger amount and for which the SPR Project is accountable. However, subsequent transfers within a site may not be with meters of the same accuracy. In this study, a very simple theory of the perfect relationship is used to evaluate the correlation (deviation) of the various measures. This theory permits separation of uncertainty and bias. Each of the four SPR sites are examined, first with comparisons between the calculated solution volumes and the sonar volumes determined during construction, then with comparisons of the oil inventories and the sonar volumes obtained either by surveying through brine prior to oil filling or through the oil directly.

  14. Evoked cavernous activity: measuring penile autonomic innervation following pelvic surgery.

    Science.gov (United States)

    Yilmaz, U; Ellis, W; Lange, P; Yang, C

    2006-01-01

    To assess cavernous nerve integrity, we measured evoked cavernous activity (ECA) in 16 men who underwent nerve sparing radical prostatectomy (NS group) and 11 men who underwent non-nerve-sparing surgery (non-NS group). The right median nerve was electrically stimulated and ECA was recorded with two concentric electromyography needles placed into the right and left cavernous bodies. We simultaneously recorded hand and foot sympathetic skin responses (SSRs) as controls. All subjects had recordable SSR, and all subjects following nerve-sparing radical prostatectomy had reproducible ECA. Of the 11 non-NS subjects, eight had no response, indicating interrupted corporal innervation. Three subjects had reproducible ECA, one of whom had a very late latency, suggesting residual innervation was present. The mean latencies of ECA were similar to foot SSR mean latencies (P>0.05), but not to hand SSR latencies. The non-NS group was significantly different from the NS group for the presence of ECA (PECA is a viable method of evaluating the autonomic innervation of the penis.

  15. Bryan Mound SPR cavern 113 remedial leach stage 1 analysis.

    Energy Technology Data Exchange (ETDEWEB)

    Rudeen, David Keith; Weber, Paula D.; Lord, David L.

    2013-08-01

    The U.S. Strategic Petroleum Reserve implemented the first stage of a leach plan in 2011-2012 to expand storage volume in the existing Bryan Mound 113 cavern from a starting volume of 7.4 million barrels (MMB) to its design volume of 11.2 MMB. The first stage was terminated several months earlier than expected in August, 2012, as the upper section of the leach zone expanded outward more quickly than design. The oil-brine interface was then re-positioned with the intent to resume leaching in the second stage configuration. This report evaluates the as-built configuration of the cavern at the end of the first stage, and recommends changes to the second stage plan in order to accommodate for the variance between the first stage plan and the as-built cavern. SANSMIC leach code simulations are presented and compared with sonar surveys in order to aid in the analysis and offer projections of likely outcomes from the revised plan for the second stage leach.

  16. Challenges of constructing salt cavern gas storage in China

    Science.gov (United States)

    Xia, Yan; Yuan, Guangjie; Ban, Fansheng; Zhuang, Xiaoqian; Li, Jingcui

    2017-11-01

    After more than ten years of research and engineering practice in salt cavern gas storage, the engineering technology of geology, drilling, leaching, completion, operation and monitoring system has been established. With the rapid growth of domestic consumption of natural gas, the requirement of underground gas storage is increasing. Because high-quality rock salt resources about 1000m depth are relatively scarce, the salt cavern gas storages will be built in deep rock salt. According to the current domestic conventional construction technical scheme, construction in deep salt formations will face many problems such as circulating pressure increasing, tubing blockage, deformation failure, higher completion risk and so on, caused by depth and the complex geological conditions. Considering these difficulties, the differences between current technical scheme and the construction scheme of twin well and big hole are analyzed, and the results show that the technical scheme of twin well and big hole have obvious advantages in reducing the circulating pressure loss, tubing blockage and failure risk, and they can be the alternative schemes to solve the technical difficulties of constructing salt cavern gas storages in the deep rock salt.

  17. A Case of Atopic Myelitis with Cervical Cavernous Angioma

    Directory of Open Access Journals (Sweden)

    Miyuki Fukuda

    2017-01-01

    Full Text Available Atopic myelitis, a type of myelitis which appears in patients with elevated serum levels of immunoglobulin E (IgE, occurs more commonly in the cervical spinal cord, but this mechanism has not yet been elucidated. Herein, we experienced a case of atopic myelitis developed during the growth of cervical cavernous angioma caused by bleeding. A 37-year-old woman suffered from hand swelling caused by a house cat licking. At the same time when cavernous angioma had grown, she experienced a numbness in her four extremities, and multifocal peritumoral hyperintense spinal cord signals were seen. The diagnosis of atopic myelitis was made because we observed significantly elevated levels of specific IgE antibody to cat dander. Symptoms disappeared immediately after steroid pulse therapy. We subsequently resected a cavernous angioma, and eosinophil invasion was found inside it. This is the first case report of atopic myelitis which developed in association with spinal cord vascular lesions. A local blood-brain barrier breakdown due to hemorrhagic lesions of the spinal cord may have contributed to the onset of atopic myelitis.

  18. Outcome of LINAC radiosurgery for a cavernous angioma

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Se Mie; Chie, Eui Kyu; Kim, Il Han; Ha, Sung Whan; Park, Charn Il [College of Medicine, Seoul National Univ., Seoul (Korea, Republic of); Park, Suk Won [College of Medicine, Halym Univ., Seoul (Korea, Republic of)

    2003-03-01

    To establish the role of stereotactic radiosurgery using a linear accelerator for the treatment of patients with cavernous angioma. Between February 1995 and May 1997, 11 patients with cavernous angioma were treated with stereotactic radiosurgery using a linear accelerator. Diagnoses were based on the magnetic resonance imaging in 8 patients, and the histological in 3. The vascular lesions were located in the brainstem (5 cases), cerebellum (2 cases) thalamus (1 case) and cerebrum (3 cases), The clinical presentation at onset included previous intracerebral hemorrhages (9 cases) and seizures (2 cases). All patients were treated with a linac-based radiosurgery. The median dose of radiation delivered was 16 Gy ranging from 14 to 24 Gy, which was typically prescribed to the 80% isodose surface (range 50-80%), corresponding to the periphery of the lesion with a single isocenter. Ten patients were followed-up. The median follow-up was 49 months ranging from 8 to 73 months, during which time two patients developed an intracerebral hemorrhage, 1 at 8 months, with the other at 64 months post radiosurgery. One patient developed neurological deficit after radiosurgery, and two developed an edema on the T2 weighted images of the MRI surrounding the radiosurgical target. The use of stereotactic radiosurgery in the treatment of a cavernous angioma may be effective in the prevention of rebleeding, and can be safely delivered. However, a longer follow-up period will be required.

  19. A Case of Atopic Myelitis with Cervical Cavernous Angioma

    Science.gov (United States)

    Manabe, Hiroaki; Sasaki, Nobuhiro; Kuroda, Masayuki; Hoshimaru, Minoru

    2017-01-01

    Atopic myelitis, a type of myelitis which appears in patients with elevated serum levels of immunoglobulin E (IgE), occurs more commonly in the cervical spinal cord, but this mechanism has not yet been elucidated. Herein, we experienced a case of atopic myelitis developed during the growth of cervical cavernous angioma caused by bleeding. A 37-year-old woman suffered from hand swelling caused by a house cat licking. At the same time when cavernous angioma had grown, she experienced a numbness in her four extremities, and multifocal peritumoral hyperintense spinal cord signals were seen. The diagnosis of atopic myelitis was made because we observed significantly elevated levels of specific IgE antibody to cat dander. Symptoms disappeared immediately after steroid pulse therapy. We subsequently resected a cavernous angioma, and eosinophil invasion was found inside it. This is the first case report of atopic myelitis which developed in association with spinal cord vascular lesions. A local blood-brain barrier breakdown due to hemorrhagic lesions of the spinal cord may have contributed to the onset of atopic myelitis. PMID:28757876

  20. Gas hydrates in gas storage caverns; Gashydrate bei der Gaskavernenspeicherung

    Energy Technology Data Exchange (ETDEWEB)

    Groenefeld, P. [Kavernen Bau- und Betriebs-GmbH, Hannover (Germany)

    1997-12-31

    Given appropriate pressure and temperature conditions the storage of natural gas in salt caverns can lead to the formation of gas hydrates in the producing well or aboveground operating facilities. This is attributable to the stored gas becoming more or less saturated with water vapour. The present contribution describes the humidity, pressure, and temperature conditions conducive to gas hydrate formation. It also deals with the reduction of the gas removal capacity resulting from gas hydrate formation, and possible measures for preventing hydrate formation such as injection of glycol, the reduction of water vapour absorption from the cavern sump, and dewatering of the cavern sump. (MSK) [Deutsch] Bei der Speicherung von Erdgas in Salzkavernen kann es unter entsprechenden Druck- und Temperaturverhaeltnissen zur Gashydratbildung in den Foerdersonden oder obertaegigen Betriebseinrichtungen kommen, weil sich das eingelagerte Gas mehr oder weniger mit Wasserdampf aufsaettigt. Im Folgenden werden die Feuchtigkeits-, Druck- und Temperaturbedingungen, die zur Hydratbildung fuehren erlaeutert. Ebenso werden die Verringerung der Auslagerungskapazitaet durch die Hydratbildung, Massnahmen zur Verhinderung der Hydratbildung wie die Injektion von Glykol, die Verringerung der Wasserdampfaufnahme aus dem Kavernensumpf und die Entwaesserung der Kavernensumpfs selbst beschrieben.

  1. Fibrosis of corpus cavernosum in animals following cavernous nerve ablation.

    Science.gov (United States)

    Hu, Wan-Li; Hu, Li-Quan; Song, Jian; Li, Shi-Wen; Zheng, Xin-Min; Cheng, Bei; Tian, Bing-Chun

    2004-06-01

    To investigate alterations of smooth muscle cells and collagen fibers in corpus cavernosum following cavernous neurectomy and its relation to the expression of transforming growth factor-beta1 (TGF-beta1). Ten adult male SD rats (neurectomy group) were subject to a bilateral cavernous nerve (CN) resection aseptically under an operating microscope, with 6 sham-operated rats as the control. Fifteen weeks after the operation, the penile specimens were collected and prepared for quantitative-analyzing of ratio of smooth muscle to collagen fibers in corpus cavernosum with confocal microscopy, and for detecting the expression of TGF-beta1 by RT-PCR and western-blot. Smooth muscle cells that show red color after fluorescent-labeling with tetramethylrhodamine isothiocyanate-phalloidin and collagen fibers that produce green autofluorescence after paraformaldehyde fixation were clearly identified under the confocal microscope. Quantification of fluorescent intensity showed that the ratio of smooth muscle to collagen fibers in corpus cavernosum in neurectomy group was 0.265 +/- 0.125, which was significantly lower than that in sham-operated group (0.760 +/- 0.196, Pcorpus cavernosum, which may be related to an increased expression of TGF-beta1 induced by hypoxia in cavernous tissue after denervation.

  2. Endovascular treatment of carotid-cavernous vascular lesions

    Directory of Open Access Journals (Sweden)

    GUILHERME BRASILEIRO DE AGUIAR

    Full Text Available ABSTRACT Objective: to evaluate the endovascular treatment of vascular lesions of the cavernous segment of the internal carotidartery (ICA performed at our institution. Methods: we conducted a descriptive, retrospective and prospective study of patients with aneurysms of the cavernous portion of the ICA or with direct carotid-cavernous fistulas (dCCF undergoing endovascular treatment. Results: we included 26 patients with intracavernous aneurysms and ten with dCCF. All aneurysms were treated with ICA occlusion. Those with dCCF were treated with occlusion in seven cases and with selective fistula occlusion in the remaining three. There was improvement of pain and ocular proptosis in all patients with dCCF. In patients with intracavernous aneurysms, the incidence of retro-orbital pain fell from 84.6% to 30.8% after treatment. The endovascular treatment decreased the dysfunction of affected cranial nerves in both groups, especially the oculomotor one. Conclusion: the endovascular treatment significantly improved the symptoms in the patients studied, especially those related to pain and oculomotor nerve dysfunction.

  3. Infiltration of Martian outflow channel floodwaters into lowland cavernous systems

    Science.gov (United States)

    Rodriguez, J. Alexis P.; Bourke, Mary; Tanaka, Kenneth L.; Miyamoto, Hideaki; Kargel, Jeffrey; Baker, Victor; Fairén, Alberto G.; Davies, Richard J.; Bridget, Lynne; Santiago, Rogelio Linares; Hernández, Mario Zarroca; Berman, Daniel C.

    2012-11-01

    The hydrosphere of Mars has remained mostly concealed within the subsurface for the past ∼3.5 Gyr. Localized rupturing of the permafrost-capped crust led to voluminous groundwater discharges that carved some of the largest known channels in the solar system. However, our knowledge of the nature of the flows and their ultimate fate remains incomplete, partly because diagnostic landforms at outflow channel termini have been largely destroyed or buried. The Hebrus Valles outflow channels were excavated by fluid discharges that emanated from two point sources, and they mostly terminate in systems of fractures and depressions within the northern plains. Our investigation indicates that outflow channel floodwaters were captured and reabsorbed into the subsurface in zones where caverns developed within the northern plains. These findings imply that the study region comprises the only known location in the Martian northern lowlands where the fate of outflow channel discharges can be assessed with confidence. We propose that evacuation of subsurface materials via mud volcanism was an important process in cavern formation. Our conceptual model provides a hypothesis to account for the fate of sediments and fluids from some of the Martian outflow channels. It also reveals a mechanism for lowland cavern formation and upper crustal volatile enrichment after the development of the Martian global cryosphere.

  4. An analysis of flow dynamics in cerebral cavernous malformation and orbital cavernous angioma using indocyanine green videoangiography.

    Science.gov (United States)

    Murakami, Kensuke; Endo, Toshiki; Tominaga, Teiji

    2012-07-01

    Cerebral cavernous malformations (CCMs) are known to be vascular anomalies with low perfusion because of being angiographically occult. We attempted direct visualization of blood flow within CCMs and orbital cavernous angiomas (CAs), and analyzed flow dynamics using indocyanine green videoangiography (ICG-VAG). This series included seven CCMs and two orbital CAs. ICG-VAG was performed to visualize blood flow of the lesions before resection. Time to peak of staining was evaluated by reviewing recorded ICG-VAG. In five of seven CCMs, stain was identified. CCMs were seen as avascular areas in both arterial and venous phases, and were stained gradually. Stain was maximized late after venous phase. The orbital CAs were also stained lately, but more intensely than CCMs. The present study directly demonstrated slow and low perfusion within CCM and orbital CA using ICG-VAG. On the basis of characteristic flow dynamics of CCMs, intraoperative ICG-VAG provides useful information in microsurgical resection.

  5. The CERN cryogenic test facility for the ATLAS barrel toroid magnets

    CERN Document Server

    Haug, F; Delruelle, N; Orlic, J P; Passardi, Giorgio; Tischhauser, Johann

    2000-01-01

    The superconducting magnet system of the ATLAS detector will consist of a central solenoid, two end-cap toroidal magnets (ECT) and the barrel toroid magnet (BT) made of eight coils symmetrically placed around the central axis of the detector. The magnets will be tested individually in a 5000 m/sup 2/ experimental area prior to their final installation at an underground cavern of the LHC Collider. For the BT magnets, a dedicated cryogenic test facility has been designed which is currently under the construction and commissioning phase. A liquid nitrogen pre-cooling unit and a 1200 W@4.5K refrigerator will allow flexible operating conditions via a rather complex distribution and transfer line system. Flow of two-phase helium for cooling the coils is provided by centrifugal pumps immersed in a saturated liquid helium bath. The integration of the pumps in an existing cryostat required the adoption of novel mechanical solutions. Tests conducted permitted the validation of the technical design of the cryostat and i...

  6. The CERN Cryogenic Test Facility for the Atlas Barrel Toroid Magnets

    CERN Document Server

    Haug, F; Delruelle, N; Orlic, J P; Passardi, Giorgio; Tischhauser, Johann

    1999-01-01

    The superconducting magnet system of the ATLAS detector will consist of a central solenoid, two end-cap toroidal magnets (ECT) and the barrel toroid magnet (BT) made of eight coils symmetrically placed around the central axis of the detector. The magnets will be tested individually in a 5000 m2 experimental area prior to their final installation at an underground cavern of the LHC Collider. For the BT magnets, a dedicated cryogenic test facility has been designed which is currently under the construction and commissioning phase. A liquid nitrogen pre-cooling unit and a 1200 W@4.5K refrigerator will allow flexible operating conditions via a rather complex distribution and transfer line system. Flow of two-phase helium for cooling the coils is provided by centrifugal pumps immersed in a saturated liquid helium bath. The integration of the pumps in an existing cryostat required the adoption of novel mechanical solutions. Tests conducted permitted the validation of the technical design of the cryostat and its ins...

  7. Cavernous sinus cavernous hemangioma: imaging features and therapeutic effect of Gamma Knife radiosurgery.

    Science.gov (United States)

    Anqi, Xiao; Zhang, Shangfu; Jiahe, Xiao; Chao, You

    2014-12-01

    To investigate the imaging features of cavernous sinus cavernous hemangioma (CSCH) and evaluate the therapeutic effect of Gamma Knife radiosurgery (GKRS) in treatment of CSCH. Fifteen patients with CSCH treated by GKRS in our institute, including 6 males and 9 females, age range 20-77 years old, were analyzed retrospectively. Three of them were given craniotomies as the initial therapy. All cases had performed conventional and contrast-enhanced MRI and 5 patients underwent dynamic enhanced MRI preoperatively. In 6 cases, the multi-directional continuous data of axial, coronal and sagittal enhanced MRI were acquired. Three cases performed digital subtraction angiography (DSA) simultaneously. The diagnoses of lesions were determined mainly depending on typical imaging features. In 3 patients, the diagnoses of CSCH were confirmed histopathologically. The radiation dosimetry was done with a goal of conformal and selective coverage of the lesion with a 50% prescription isodose line. The mean marginal dose constituted 13.4 Gy (range 10-16 Gy). After GKRS was performed, all patients were arranged regular clinical and MRI follow-up every 6 months during the first 12 months, and once per year thereafter. On MRI, the lesions were typically demonstrated as iso/hypo-intensities on T1WI and remarkable hyper-intensities on T2WI, and apparent homogeneous enhancement. The phenomenon of dynamic enhancement was found in 11 cases. The progressive enhancing process from heterogeneous to uniform was displayed in the 5 patients performed same-slice dynamic MRI, including imaging characteristics of 'edge to center' enhancement in 2 case. In the other 6 cases, the delayed homogeneous enhancement of lesion was observed. Ten patients obtained radiological follow-up results after GKRS. Reviewing the follow-up data of 8 patients during the period of 3-6 months, the lesions were apparently shrunk in 5 patients with shrinkage rate of 20.8-46.8%. In 4 patients with imaging follow-up during the

  8. Analysis of cavern and well stability at the West Hackberry SPR site using a full-dome model.

    Energy Technology Data Exchange (ETDEWEB)

    Sobolik, Steven R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-08-01

    This report presents computational analyses that simulate the structural response of caverns at the Strategic Petroleum Reserve (SPR) West Hackberry site. The cavern field comprises 22 caverns. Five caverns (6, 7, 8, 9, 11) were acquired from industry and have unusual shapes and a history dating back to 1946. The other 17 caverns (101-117) were leached according to SPR standards in the mid-1980s and have tall cylindrical shapes. The history of the caverns and their shapes are simulated in a three-dimensional geomechanics model of the site that predicts deformations, strains, and stresses. Future leaching scenarios corresponding to oil drawdowns using fresh water are also simulated by increasing the volume of the caverns. Cavern pressures are varied in the model to capture operational practices in the field. The results of the finite element model are interpreted to provide information on the current and future status of subsidence, well integrity, and cavern stability. The most significant results in this report are relevant to Cavern 6. The cavern is shaped like a bowl with a large ceiling span and is in close proximity to Cavern 9. The analyses predict tensile stresses at the edge of the ceiling during repressurization of Cavern 6 following workover conditions. During a workover the cavern is at low pressure to service a well. The wellhead pressures are atmospheric. When the workover is complete, the cavern is repressurized. The resulting elastic stresses are sufficient to cause tension around the edge of the large ceiling span. With time, these stresses relax to a compressive state because of salt creep. However, the potential for salt fracture and propagation exists, particularly towards Cavern 9. With only 200 feet of salt between the caverns, the operational consequences must be examined if the two caverns become connected. A critical time may be during a workover of Cavern 9 in part because of the operational vulnerabilities, but also because dilatant damage

  9. Geomechanical Analysis and Design Considerations for Thin-Bedded Salt Caverns

    Energy Technology Data Exchange (ETDEWEB)

    Michael S. Bruno

    2005-06-15

    The bedded salt formations located throughout the United States are layered and interspersed with non-salt materials such as anhydrite, shale, dolomite and limestone. The salt layers often contain significant impurities. GRI and DOE have initialized this research proposal in order to increase the gas storage capabilities by providing operators with improved geotechnical design and operating guidelines for thin bedded salt caverns. Terralog has summarized the geologic conditions, pressure conditions, and critical design factors that may lead to: (1) Fracture in heterogeneous materials; (2) Differential deformation and bedding plane slip; (3) Propagation of damage around single and multiple cavern; and (4) Improved design recommendations for single and multiple cavern configurations in various bedded salt environments. The existing caverns within both the Permian Basin Complex and the Michigan and Appalachian Basins are normally found between 300 m to 1,000 m (1,000 ft to 3,300 ft) depth depending on local geology and salt dissolution depth. Currently, active cavern operations are found in the Midland and Anadarko Basins within the Permian Basin Complex and in the Appalachian and Michigan Basins. The Palo Duro and Delaware Basins within the Permian Basin Complex also offer salt cavern development potential. Terralog developed a number of numerical models for caverns located in thin bedded salt. A modified creep viscoplastic model has been developed and implemented in Flac3D to simulate the response of salt at the Permian, Michigan and Appalachian Basins. The formulation of the viscoplastic salt model, which is based on an empirical creep law developed for Waste Isolation Pilot Plant (WIPP) Program, is combined with the Drucker-Prager model to include the formation of damage and failure. The Permian salt lab test data provided by Pfeifle et al. 1983, are used to validate the assumptions made in the material model development. For the actual cavern simulations two

  10. Structural Stability Monitoring of a Physical Model Test on an Underground Cavern Group during Deep Excavations Using FBG Sensors.

    Science.gov (United States)

    Li, Yong; Wang, Hanpeng; Zhu, Weishen; Li, Shucai; Liu, Jian

    2015-08-31

    Fiber Bragg Grating (FBG) sensors are comprehensively recognized as a structural stability monitoring device for all kinds of geo-materials by either embedding into or bonding onto the structural entities. The physical model in geotechnical engineering, which could accurately simulate the construction processes and the effects on the stability of underground caverns on the basis of satisfying the similarity principles, is an actual physical entity. Using a physical model test of underground caverns in Shuangjiangkou Hydropower Station, FBG sensors were used to determine how to model the small displacements of some key monitoring points in the large-scale physical model during excavation. In the process of building the test specimen, it is most successful to embed FBG sensors in the physical model through making an opening and adding some quick-set silicon. The experimental results show that the FBG sensor has higher measuring accuracy than other conventional sensors like electrical resistance strain gages and extensometers. The experimental results are also in good agreement with the numerical simulation results. In conclusion, FBG sensors could effectively measure small displacements of monitoring points in the whole process of the physical model test. The experimental results reveal the deformation and failure characteristics of the surrounding rock mass and make some guidance for the in situ engineering construction.

  11. Structural Stability Monitoring of a Physical Model Test on an Underground Cavern Group during Deep Excavations Using FBG Sensors

    Directory of Open Access Journals (Sweden)

    Yong Li

    2015-08-01

    Full Text Available Fiber Bragg Grating (FBG sensors are comprehensively recognized as a structural stability monitoring device for all kinds of geo-materials by either embedding into or bonding onto the structural entities. The physical model in geotechnical engineering, which could accurately simulate the construction processes and the effects on the stability of underground caverns on the basis of satisfying the similarity principles, is an actual physical entity. Using a physical model test of underground caverns in Shuangjiangkou Hydropower Station, FBG sensors were used to determine how to model the small displacements of some key monitoring points in the large-scale physical model during excavation. In the process of building the test specimen, it is most successful to embed FBG sensors in the physical model through making an opening and adding some quick-set silicon. The experimental results show that the FBG sensor has higher measuring accuracy than other conventional sensors like electrical resistance strain gages and extensometers. The experimental results are also in good agreement with the numerical simulation results. In conclusion, FBG sensors could effectively measure small displacements of monitoring points in the whole process of the physical model test. The experimental results reveal the deformation and failure characteristics of the surrounding rock mass and make some guidance for the in situ engineering construction.

  12. Onyx embolization of dural arteriovenous fistulas of the cavernous sinus through the superior pharyngeal branch of the ascending pharyngeal artery

    OpenAIRE

    Pero, Guglielmo; Quilici, Luca; Piano, Mariangela; Valvassori, Luca; Boccardi, Edoardo

    2014-01-01

    We report three cases of dural arteriovenous fistula (DAVF) of the cavernous sinus treated by Onyx injection through the superior pharyngeal branch of the ascending pharyngeal artery. The treatment of choice of DAVFs of the cavernous sinus is endovascular, and it is preferentially done via transvenous occlusion of the cavernous sinus. The cavernous sinus can be reached through either the inferior petrosal sinus or the superior ophthalmic vein. When these venous routes are occluded, the first ...

  13. Features of West Hackberry SPR Caverns and Internal Structure Of the Salt Dome

    Energy Technology Data Exchange (ETDEWEB)

    Munson, Darrell Eugene [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Underground Storage Technology Dept.

    2006-09-01

    The intent of this report is to examine the internal structure of the West Hackberry salt dome utilizing the information from the geometric configuration of the internal cavern surfaces obtained from graphical representations of sonar survey data. In a general sense, the caverns of West Hackberry are remarkable in the symmetry of their shapes. There are only rather moderate deviations from what would be considered an ideal cylindrical solution mining geometry in these caverns. This finding is in marked contrast to the directional solutioning found in the elliptical cross sectioned, sometimes winged, caverns of Big Hill. None of the persistent lineaments prevalent in Big Hill caverns are evident in West Hackberry caverns. Irregularities of the West Hackberry caverns are restricted to preferential solution formed pits and protuberances with moderate dimensions. In fact, the principal characteristic of West Hackberry caverns is the often large sections of smooth and cylindrical cavern wall. Differences in the cavern characteristics between West Hackberry and Big Hill suggest that the former dome is quite homogeneous, while the latter still retains strong remnants of the interbeds of the original bedded Louann salt. One possible explanation is that the source of the two domes, while both from the Louann mother salt, differs. While the source of the Big Hill dome is directly from the mother salt bed, it appears that the West Hackberry arises from a laterally extruded sill of the mother salt. Consequently, the amount of deformation, and hence, mixing of the salt and interbed material in the extruded sill is significantly greater than would be the case for the directly formed diapir. In West Hackberry, remnants of interbeds apparently no longer exist. An important aspect of the construction of the West Hackberry caverns is the evidence of an attempt to use a uniform solutioning construction practice. This uniformity involved the utilization of single well solutioning and

  14. Intra-Root Cavernous Angioma of the Cauda Equina : A Case Report and Review of the Literature

    Science.gov (United States)

    Chun, Sang Woo; Lee, Tae Hoon; Koo, Hye Soo

    2010-01-01

    Authors experienced intra-root cavernous angioma which is very rare case among cavernous angiomas of cauda equina. Our intra-root cavernous angioma was confirmed by findings from operating field and microscopic examination. We report this case with review of the literature. PMID:20461171

  15. Novel Optical Methods for Identification, Imaging, and Preservation of the Cavernous Nerves Responsible for Penile Erections during Prostate Cancer Surgery

    Science.gov (United States)

    2011-03-01

    Novel Optical Methods for Identification, Imaging, and Preservation of the Cavernous Nerves Responsible for Penile Erections during Prostate...5a. CONTRACT NUMBER Preservation of the Cavernous Nerves Responsible for Penile Erections During Prostate Cancer Surgery 5b. GRANT...understanding of the location of the cavernous nerves, which are responsible for erectile function. Advances in id entification and preservation of

  16. Intra-Root Cavernous Angioma of the Cauda Equina : A Case Report and Review of the Literature

    OpenAIRE

    Chun, Sang Woo; Kim, Sang Jin; Lee, Tae Hoon; Koo, Hye Soo

    2010-01-01

    Authors experienced intra-root cavernous angioma which is very rare case among cavernous angiomas of cauda equina. Our intra-root cavernous angioma was confirmed by findings from operating field and microscopic examination. We report this case with review of the literature.

  17. Cavernous angioma: a clinical study of 35 cases with review of the literature.

    Science.gov (United States)

    Ebrahimi, Azadeh; Etemadifar, Masoud; Ardestani, Pooneh M; Maghzi, Amir H; Jaffe, Stephen; Nejadnik, Hossein

    2009-10-01

    Cavernous angioma is a vascular malformation which can be found in any region within the central nervous system. There are few clinical and demographic cavernous angioma studies with large sample sizes. Therefore, the present study was designed to provide further information on the clinical and demographic characteristics of cavernous angioma using a relatively large sample of Persian patients. Patients with cavernous angioma were recruited from the outpatient neurology clinics in Isfahan, Iran, from October 2003 to October 2006. In all cases, the diagnosis of cavernous angioma was based on brain magnetic resonance imaging. There were 35 patients (female/male: 17 : 18) identified with cavernous angioma. The mean age at presentation was 28.8 years. Initial manifestations included seizures in 16, headache in 11 and intracranial hemorrhage in eight patients. During follow-up, all patients experienced seizures and 19 developed headaches. Depression, vertigo, nausea, vomiting, disequilibrium, loss of consciousness and sensorimotor symptoms were also observed. Some of the findings of the present study were in accordance with previous studies. However, more of our patients with positive family history had solitary rather than multiple lesions, and more of our patients had generalized tonic-clonic seizures rather than partial seizures. Moreover, our data demonstrated that if there is a history of cavernous angioma with intracranial hemorrhage in family members, the presenting cavernous angioma patient is more prone to intracranial hemorrhage.

  18. Endovascular management of dural fistulas into the cavernous sinus. A systematic review

    Directory of Open Access Journals (Sweden)

    Moscote-Salazar Luis Rafael

    2014-06-01

    Full Text Available Background: Dural fistula to the cavernous sinus (DFCS is an infrequent pathology that consists in the anomalous communication between the meningeal branches of the internal carotid artery (ICA and/or the external carotid artery (ECA and the cavernous sinus. Aim: To perform a systematic review to evaluate clinical and imaging findings in DFCS, and current indications for treatment.

  19. Penile duplex pharmaco-ultrasonography revisited: revalidation of the parameters of the cavernous arterial response

    NARCIS (Netherlands)

    Speel, T. G. W.; van Langen, H.; Wijkstra, H.; Meuleman, E. J. H.

    2003-01-01

    PURPOSE: We revalidate parameters of the cavernous arterial response (peak systolic blood flow velocity) and acceleration time using penile duplex pharmaco-ultrasonography. MATERIALS AND METHODS: Blood flow velocity in the cavernous artery following pharmaco-stimulation was determined with duplex

  20. ATLAS's inner detector installed in the heart of the experiment

    CERN Multimedia

    2006-01-01

    The ATLAS collaboration recently celebrated a major engineering milestone, namely the transport and installation of the central part of the inner detector (ID-barrel) into the ATLAS detector. Right: Engineers and technicians work to carefully align and install the inner detector in the centre of ATLAS.Left: The crane used in the carefully coordinated effort by the ATLAS collaboration to lower down the fragile inner detector 100 metres underground to its new home. Many members of the collaboration gathered to witness this moment at Point 1. After years of design, construction and commissioning, the two outer detectors (TRT and SCT) of the inner detector barrel (ID-barrel) were moved from the SR1 cleanroom to the ATLAS cavern. The barrel was moved across the car park from Building 2175 to SX1. Although only a journey of about 100 metres, this required weeks of planning and some degree of luck as far as the weather was concerned. Special measures were in place to minimize shock and vibration during transportati...

  1. Increased number of white matter lesions in patients with familial cerebral cavernous malformations.

    Science.gov (United States)

    Golden, M J; Morrison, L A; Kim, H; Hart, B L

    2015-05-01

    Familial cerebral cavernous malformations, an autosomal dominant disorder, result in excess morbidity and mortality in affected patients. The disorder is most prevalent in the Southwest United States, where the affected families are most often carriers of the CCM1-KRIT1 Common Hispanic Mutation. The brain and spinal cord parenchyma in these individuals is usually affected by multiple cavernous malformations. Previous studies have shown abnormalities of endothelial cell junctions and the blood-brain barrier in cerebral cavernous malformations. Endothelial cell abnormalities have also been described in pathologic studies of white matter hyperintensities. We compared the prevalence of white matter hyperintensities in a population with known familial cerebral cavernous malformations. We examined 191 subjects with familial cerebral cavernous malformations who were enrolled into an institutional review board-approved study. All carry the same Common Hispanic Mutation in the CCM1 gene. Each subject underwent 3T MR imaging, including gradient recalled-echo, SWI, and FLAIR sequences. The number of cavernous malformations and the number of nonhemorrhagic white matter hyperintensities were counted. Subjects older than 60 years of age were excluded due to the high prevalence of white matter lesions in this population, and children younger than 6 were excluded due to potential sedation requirements. Logistic regression analysis was performed to determine the prevalence of abnormal white matter hyperintensities in those with familial cerebral cavernous malformations compared with healthy controls or those with sporadic cerebral cavernous malformation within the familial cerebral cavernous malformations group; it was also performed to evaluate the associations between abnormal white matter hyperintensities and age, sex, headaches, thyroid disease, diabetes, hypertension, hyperlipidemia, seizure history, or modified Rankin Scale score. Familial CCM1 carriers have a higher

  2. Commissioning of the ATLAS Liquid Argon Calorimeter

    CERN Document Server

    Gibson, A; The ATLAS collaboration

    2009-01-01

    The Liquid Argon calorimeter (LAr) is one of the main sub-detectors in the ATLAS experiment at the LHC. It provides precision measurements of electrons, photons, jets and missing transverse energy produced in the LHC pp collisions. The LAr calorimeter has been installed in the ATLAS cavern and filled with liquid argon since 2006. The electronic calibration of the readout system, a critical system for precision measurements, has been continuously exercised in the commissioning phase, resulting in a fully commissioned calorimeter with its readout and a small number of problematic channels. A total of only 0.02% of the read out channels are dead beyond repair and 0.4% need special treatment for calibration. Throughout the last two years a large amount of calibration data has been collected. Cosmic muon data, first triggered via specially developed trigger boards on the LVL1 output of the Tile calorimeter and later with the standard ATLAS LVL1 calorimeter trigger, have been recorded at various stages of commissio...

  3. Giant cavernous malformations in young adults: report of two cases, radiological findings and surgical consequences.

    Science.gov (United States)

    Parizel, M R; Menovsky, T; Van Marck, V; Lammens, M; Parizel, P M

    2014-01-01

    Cerebral cavernous malformations, also known as cavernous angioma or cavernoma, are a type of vascular disorder. They consist of abnormally large vascular cavities or sinusoid channels of varying size. The majority of cavernous malformations in the brain are small and do not always present with symptoms. A minority of large cavernous malformations, known as giant cavernous malformations (GCM), can cause neurological symptoms (such as headaches, focal neurologic deficits and seizures), which are probably related to hemorrhage and mass effect. GCM grow steadily in size over time, due to repetitive episodes of bleeding. The purpose of this paper is to document two case reports of patients with GCM, illustrate the radiological appearance, discuss the neurosurgical consequences, and to provide a literature analysis.

  4. Cavernous angioma of the cauda equina: a case report and systematic review of the literature.

    Science.gov (United States)

    Nie, Q-B; Chen, Z; Jian, F-Z; Wu, H; Ling, F

    2012-01-01

    Cavernous angioma is an uncommon vascular malformation of the central nervous system with a tumoural aspect. Spinal cavernous angioma mainly occurs within vertebral bodies; only 3-5% of tumours are located entirely in the vertebral canal. This case report describes a case of cavernous angioma, originating from the nerve roots of the cauda equina at the L1 level, in a 57-year-old woman presenting with acute lower back pain. The lesion was surgically resected 6 months after symptom onset and the structural integrity of the nerve root was maintained. Histopathological examination confirmed the diagnosis of cavernous angioma. The patient experienced no postoperative neurological deficit or recurrence. The diagnosis, histopathological features and surgical treatment of this case are presented, together with a literature review of clinical details and surgical procedures undertaken in cases of cavernous angioma of the cauda equina.

  5. Cavernous sinus syndrome associated with metastatic colorectal cancer and perineural spread along the trigeminal nerve.

    Science.gov (United States)

    Nassrallah, Georges; Sun, Vincent; Guiot, Marie-Christine; Mikhail, Mikel; Arthurs, Bryan

    2017-06-01

    We report the case of a patient with cavernous sinus syndrome associated with biopsy-confirmed metastasis from colorectal cancer. A patient known for laryngeal carcinoma and metastatic colorectal carcinoma presented with symptoms of left trigeminal neuralgia and progressive, near-complete ophthalmoplegia. Magnetic resonance imaging (MRI) revealed a mass in the left cavernous sinus, extending into Meckel's cave with perineural spread along the mandibular branch of the left trigeminal nerve. A transsphenoidal biopsy was performed and demonstrated metastatic colon adenocarcinoma. We review the existing literature on colorectal cancer associated cavernous sinus syndrome. Cavernous sinus metastasis from colorectal cancer is exceedingly rare. We report the second case of this entity with histopathologic confirmation, and the first case with concurrent perineural spread involving the trigeminal nerve. Cavernous sinus metastasis may represent a poor prognostic factor in colorectal cancer.

  6. 24 October 2014 - President of the Republic of Ecuador R. Correa Delgado signing the guest book with Vice President L. Moreno and Director for Research and Scientific Computing S. Bertolucci.

    CERN Multimedia

    Guillaume, Jeanneret

    2014-01-01

    visiting the ATLAS experimental cavern with Collaboration PSokesperson D. Charlton and ATLAS User F. Monticelli; throughout accompanied by Adviser for Ecuador J. Salicio Diez and Director for Research and Scientific Computing S. Bertolucci.

  7. Direct orbital puncture of the cavernous sinus for the treatment of a carotid-cavernous dural AV fistula with a concomitant venous/lymphatic malformation.

    Science.gov (United States)

    Coumou, Adriaan D; van den Berg, René; Bot, Joost C; Beetsma, Daan B; Saeed, Peerooz

    2014-02-01

    A 37- year old male with a long history of a left orbital venous/lympathic malformation presented with ocular injection, increased proptosis and reduced left vision. Angiography demonstrated a carotid cavernous dural AV fistula combined with a concomitant venous/lymphatic malformation. After attempts at transvenous embolization, a direct uncomplicated transorbital puncture of the cavernous sinus via a lateral orbitotomy was performed with complete resolution of ocular symptoms.

  8. Atlas civil engineering

    CERN Multimedia

    2002-01-01

    The first things lowered to the cavern were not parts of the new detector or parts for the accelerator rather than the machines digging the cavern bigger and lifts that transport stones and other excess material up to the surface. This work was very demanding already.

  9. Development of a Micro Pixel Chamber for the ATLAS Upgrade

    CERN Document Server

    Ochi, Atsuhiko; Komai, Hidetoshi; Edo, Yuki; Yamaguchi, Takahiro

    2012-01-01

    The Micro Pixel Chamber (μ-PIC) is being developed a sacandidate for the muon system of the ATLAS detector for upgrading in LHC experiments. The μ-PIC is a micro-pattern gaseous detector that doesn’t have floating structure such as wires, mesh, or foil. This detector can be made by printed-circuit-board (PCB) technology, which is commercially available and suited for mass production. Operation tests have been performed under high flux neutrons under similar conditions to the ATLAS cavern. Spark rates are measured using several gas mixtures under 7 MeV neutron irradiation, and good properties were observed using neon, ethane, and CF4 mixture of gases.Using resistive materials as electrodes, we are also developing a new μ-PIC, which is not expected to damage the electrodes in the case of discharge sparks.

  10. Interconnected cavernous structure of bacterial fruiting bodies.

    Directory of Open Access Journals (Sweden)

    Cameron W Harvey

    Full Text Available The formation of spore-filled fruiting bodies by myxobacteria is a fascinating case of multicellular self-organization by bacteria. The organization of Myxococcus xanthus into fruiting bodies has long been studied not only as an important example of collective motion of bacteria, but also as a simplified model for developmental morphogenesis. Sporulation within the nascent fruiting body requires signaling between moving cells in order that the rod-shaped self-propelled cells differentiate into spores at the appropriate time. Probing the three-dimensional structure of myxobacteria fruiting bodies has previously presented a challenge due to limitations of different imaging methods. A new technique using Infrared Optical Coherence Tomography (OCT revealed previously unknown details of the internal structure of M. xanthus fruiting bodies consisting of interconnected pockets of relative high and low spore density regions. To make sense of the experimentally observed structure, modeling and computer simulations were used to test a hypothesized mechanism that could produce high-density pockets of spores. The mechanism consists of self-propelled cells aligning with each other and signaling by end-to-end contact to coordinate the process of differentiation resulting in a pattern of clusters observed in the experiment. The integration of novel OCT experimental techniques with computational simulations can provide new insight into the mechanisms that can give rise to the pattern formation seen in other biological systems such as dictyostelids, social amoeba known to form multicellular aggregates observed as slugs under starvation conditions.

  11. Cavernous angioma of brain stem mimicking multiple sclerosis.

    Science.gov (United States)

    Honczarenko, K; Fryze, C; Nowacki, P; Osuch, Z; Grzelec, H; Fabian, A

    1995-01-01

    A 14-year-old boy was admitted to our Department due to peripheral palsy of right VII and bilateral of the VI cranial nerves, spasticity, cerebellar symptoms as well as to dysphagia and dysarthria. In general, he was hospitalized 13 times because of the disease of a relapsing-remitting and next progressive course. He died 31 years after onset of the disease. Multiple sclerosis was diagnosed. Brain autopsy revealed tumor involving almost all brain stem structures and a part of right cerebellar hemisphere. Histologically, cavernous angioma was diagnosed.

  12. Cavernous angioma of the corpus callosum presenting with acute psychosis.

    Science.gov (United States)

    Pavesi, Giacomo; Causin, Francesco; Feletti, Alberto

    2014-01-01

    Psychiatric symptoms may occasionally be related to anatomic alterations of brain structures. Particularly, corpus callosum lesions seem to play a role in the change of patients' behavior. We present a case of a sudden psychotic attack presumably due to a hemorrhagic cavernous angioma of the corpus callosum, which was surgically removed with complete resolution of symptoms. Although a developmental defect like agenesis or lipoma is present in the majority of these cases, a growing lesion of the corpus callosum can rarely be the primary cause. Since it is potentially possible to cure these patients, clinicians should be aware of this association.

  13. Cavernous Angioma of the Corpus Callosum Presenting with Acute Psychosis

    Directory of Open Access Journals (Sweden)

    Giacomo Pavesi

    2014-01-01

    Full Text Available Psychiatric symptoms may occasionally be related to anatomic alterations of brain structures. Particularly, corpus callosum lesions seem to play a role in the change of patients’ behavior. We present a case of a sudden psychotic attack presumably due to a hemorrhagic cavernous angioma of the corpus callosum, which was surgically removed with complete resolution of symptoms. Although a developmental defect like agenesis or lipoma is present in the majority of these cases, a growing lesion of the corpus callosum can rarely be the primary cause. Since it is potentially possible to cure these patients, clinicians should be aware of this association.

  14. Neodymium YAG laser for treatment of oral cavernous hemangiomas

    Science.gov (United States)

    Bradley, Paul F.

    1999-02-01

    Oral cavernous haemangiomas are common lesions which may require treatment due to episodes of bleeding when bitten or deformity particularly when involving the lips and/or cheeks. Surgery can be hazardous due to haemorrhage while cryosurgery tends to be tedious for large lesions and be accompanied by major oedema. Sclerosants produce hard bulky masses. Embolization is seldom helpful due to lack of arterial feeders. The Nd:YAG laser is proving a useful modality in the oro-facial region and appeared worth investigating for these lesions in a laboratory animal model, by thermography and in the clinical situation.

  15. 16 December 2011 - Israeli Minister of Industry, Trade and Labour S.Simhon visiting ATLAS undeground area, ATLAS visitor centre and LHC tunnel with Senior Physicist G. Mikenberg. ATLAS Collaboration Former Spokesperson is also present.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    Israeli minister of industry, trade and labour, Shalom Simhon, was welcomed in the ATLAS visitor centre before he toured the ATLAS underground experimental area, where he could see the ATLAS detector. He also had a chance to see the LHC tunnel and the CERN Control Centre.

  16. Literature Survey Concerning the Feasibility of Remedial Leach for Select Phase I Caverns

    Energy Technology Data Exchange (ETDEWEB)

    Weber, Paula D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Flores, Karen A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lord, David L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-09-01

    Bryan Mound 5 ( BM5 ) and West Hackberry 9 ( WH9 ) have the potential to create a significant amount of new storage space should the caverns be deemed "leach - ready". This study discusses the original drilling history of the caverns, surrounding geology, current stability, and, based on this culmination of data, makes a preliminary assessment of the leach potential for the cavern. The risks associated with leaching BM5 present substantial problems for the SPR . The odd shape and large amount of insoluble material make it difficult to de termine whether a targeted leach would have the desired effect and create useable ullage or further distort the shape with preferential leaching . T he likelihood of salt falls and damaged or severed casing string is significant . In addition, a targeted le ach would require the relocation of approximately 27 MMB of oil . Due to the abundance of unknown factors associated with this cavern, a targeted leach of BM5 is not recommended. A targeted leaching of the neck of WH 9 could potentially eliminate or diminis h the mid - cavern ledge result ing in a more stable cavern with a more favorable shape. A better understanding of the composition of the surrounding salt and a less complicated leaching history yields more confidence in the ability to successfully leach this region. A targeted leach of WH9 can be recommended upon the completion of a full leach plan with consideration of the impacts upon nearby caverns .

  17. Superior Ophthalmic Vein Access for Embolization of an Indirect Carotid Cavernous Fistula.

    Science.gov (United States)

    Haider, Ali S; Garg, Prabhat; Leonard, Dean; Osumah, Tijani; Khan, Umair; Vayalumkal, Steven; Lee, Lyndon K; Nguyen, Phu; Gilliland, Grant; Layton, Kennith F

    2017-09-01

    Carotid cavernous fistulae (CCF) are defined as abnormal connections between the carotid circulation and cavernous sinus. CCFs can be categorized as being direct or indirect. Direct CCFs are usually associated with trauma, whereas indirect CCFs are associated with revascularization following cavernous sinus thrombosis. We present a case of a 53-year-old male who presented with tinnitus, proptosis, conjunctivitis, and blurry vision. The patient had a recent endovascular transvenous embolization that was only partially successful, with a residual carotid cavernous fistula draining to the left superior ophthalmic vein and multiple cortical veins. A physical examination of the patient showed elevated intraocular pressures bilaterally. The patient had a high-flow indirect carotid cavernous fistula with bilateral superior ophthalmic vein (SOV) and retrograde cortical vein drainage. The SOV was punctured with a micropuncture needle and was used to successfully gain access to the cavernous sinus. Multiple coils were placed in the posterior aspect of the sinus until there was complete occlusion of venous flow. Coils were packed up to the posterior aspect of the orbit near the junction of the cavernous sinus with the SOV, and the embolization was successful. Indirect CCFs have gradual onset and are usually low-flow. Low-flow CCFs might improve with medical management.Some CCFs may cause ocular manifestations and can be symptomatically managed with prism therapy or ocular patching for diplopia, lubrication for keratopathy, or topical agents for elevated intraocular pressures. However, patients presenting with persistent ocular morbidity may require surgical or endovascular intervention.

  18. Transorbital Cavernous Sinus Direct Puncture : Alternative to treat dural arteriovenous fistula.

    Science.gov (United States)

    Trivelato, Felipe Padovani; Manzato, Luciano Bambini; Filho, Paulo Moacir Mesquita; Ulhôa, Alexandre Cordeiro; Vanzin, José Ricardo; Abud, Daniel Giansante; Rezende, Marco Túlio Salles

    2016-08-09

    The authors present a retrospective series of their clinical experience in the treatment of cavernous dural arteriovenous fistulas (DAVF) by direct transorbital puncture of the cavernous sinus as an alternative to the endovascular approach. Between October 2012 and September 2014, eight patients harboring cavernous DAVF underwent percutaneous treatment by direct transorbital puncture of the cavernous sinus at three institutions. All patients presented with ocular symptoms. Standard endovascular approaches, including transvenous and transarterial routes, were primarily attempted without success in all cases. Direct puncture was performed through two different approaches, namely inferolateral and superomedial. The entry point was the inferior and superior eyelid, respectively. Embolization was performed with coils or Onyx (Covidien, Irvine, CA). Immediate and late angiographies were used to evaluate the occlusion of the fistula. Of the patients seven had complete occlusion of the cavernous DAVFs noted on the immediate and follow-up angiograms and one patient had residual filling but reduction of the shunt resulted in clinical improvement. None of the patients had worsening of neurological function. One case was complicated by inadvertent internal carotid puncture but without clinical manifestations. One patient experienced postoperative superior ophthalmic vein thrombosis. In very specific cases, when endovascular access is not possible or fails to occlude cavernous DAVF, direct transorbital puncture of the cavernous sinus was shown to be feasible, safe and very effective.

  19. Mongolian Atlas

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Climatic atlas dated 1985, in Mongolian, with introductory material also in Russian and English. One hundred eight pages in single page PDFs.

  20. A Variable-Parameter Creep Damage Model Incorporating the Effects of Loading Frequency for Rock Salt and Its Application in a Bedded Storage Cavern

    Science.gov (United States)

    Ma, Linjian; Wang, Mingyang; Zhang, Ning; Fan, Pengxian; Li, Jie

    2017-09-01

    Laboratory tests were conducted to assess the effects of the loading frequency on the time-dependent behavior and damage properties of rock salt under confining stress states. Axial two-stage irreversible deformation based on the loci of the minimum load of each cycle was observed, and this observation was similar to the result of conventional creep tests under static loads. The unloading modulus decreased exponentially with respect to time, and the damage variable was represented in terms of the decay of the material stiffness. To account for the effects of the loading frequency on the time-dependent degradation of rock salt, a unified damage evolution equation was formulated based on the experimental results. A creep damage model of rock salt was proposed by introducing non-stationary modular components into the Burgers viscoelastic model. Numerical simulation was performed using the newly developed model to evaluate the stability and serviceability of a storage cavern in a bedded salt formation under various loading scenarios. The simulated results indicate that a lower injection-withdrawal frequency results in a greater volume convergence rate and a wider dilatancy region of the storage cavern. Additionally, the stress concentration and dilatancy of the surrounding rock mass extend much deeper into the mudstone interbeds than into other regions of the cavern.

  1. Transplantation of muscle-derived stem cells into the corpus cavernosum restores erectile function in a rat model of cavernous nerve injury.

    Science.gov (United States)

    Woo, Jang Chun; Bae, Woong Jin; Kim, Su Jin; Kim, Sung Dae; Sohn, Dong Wan; Hong, Sung Hoo; Lee, Ji Youl; Hwang, Tae-Kon; Sung, Young Chul; Kim, Sae Woong

    2011-05-01

    Muscle-derived stem cells (MDSCs) harvested from skeletal muscles have the advantage of providing easier access and do not pose the immunogenic risks of embryonic stem cells. We investigated the effect of intracavernosal transplantation of MDSCs on erectile function in rats with bilateral cavernous nerve injury. Adult male white rats underwent experimentation in 3 groups: group I, sham operation; group II, bilateral cavernous nerve injury; group III, bilateral cavernous nerve injury with MDSC injection. MDSCs were harvested from the femoral muscle of rats and were then injected into the cavernosum. Survival of MDSCs and measurement of erectile function was studied after 4 weeks. We checked the intracavernosal pressure (ICP) and obtained penile tissue. The expression of cyclic guanosine monophosphate (cGMP) was analyzed. Four weeks after transplantation, PKH-26-labeled MDSCs were identified in the cavernosal tissues of group III. Peak ICP and the drop rate of group II were 52±8.7 mmHg and 34±6.5 mmHg/min, respectively, whereas peak ICP and the drop rate of group III were 97±15.6 mmHg and 17±4.9 mmHg/min, respectively, showing that erectile function improved after MDSC transplantation (pcavernous nerve injury rat model, intracavernosal transplantation of MDSCs showed acceptable survival of MDSCs as well as improvement of erectile function.

  2. Role of Delta-Notch signaling in cerebral cavernous malformations.

    Science.gov (United States)

    Kar, Souvik; Baisantry, Arpita; Nabavi, Arya; Bertalanffy, Helmut

    2016-10-01

    Cerebral cavernous malformations (CCM) commonly known as cavernous hemangioma are associated with abnormally enlarged thin-walled blood vessels. As a result, these dilated capillaries are prone to leakage and result in hemorrhages. Clinically, such hemorrhages lead to severe headaches, focal neurological deficits, and epileptic seizures. CCM is caused by loss of function mutations in one of the three well-known CCM genes: Krev interaction trapped 1 (KRIT1), OSM, and programmed cell death 10 (PDCD10). Loss of CCM genes have been shown to be synergistically related to decreased Notch signaling and excessive angiogenesis. Despite recent evidences indicating that Notch signaling plays a pivotal role in regulating angiogenesis, the role of Notch in CCM development and progression is still not clear. Here, we provide an update literature review on the current knowledge of the structure of Notch receptor and its ligands, its relevance to angiogenesis and more precisely to CCM pathogenesis. In addition to reviewing the current literatures, this review will also focus on the cross talk between Delta-Notch and vascular endothelial growth factor (VEGF) signaling in angiogenesis and in CCM pathogenesis. Understanding the role of Notch signaling in CCM development and progression might help provide a better insight for novel anti-angiogenic therapies.

  3. PDCD10 gene mutations in multiple cerebral cavernous malformations.

    Science.gov (United States)

    Cigoli, Maria Sole; Avemaria, Francesca; De Benedetti, Stefano; Gesu, Giovanni P; Accorsi, Lucio Giordano; Parmigiani, Stefano; Corona, Maria Franca; Capra, Valeria; Mosca, Andrea; Giovannini, Simona; Notturno, Francesca; Ciccocioppo, Fausta; Volpi, Lilia; Estienne, Margherita; De Michele, Giuseppe; Antenora, Antonella; Bilo, Leda; Tavoni, Antonietta; Zamponi, Nelia; Alfei, Enrico; Baranello, Giovanni; Riva, Daria; Penco, Silvana

    2014-01-01

    Cerebral cavernous malformations (CCMs) are vascular abnormalities that may cause seizures, intracerebral haemorrhages, and focal neurological deficits. Familial form shows an autosomal dominant pattern of inheritance with incomplete penetrance and variable clinical expression. Three genes have been identified causing familial CCM: KRIT1/CCM1, MGC4607/CCM2, and PDCD10/CCM3. Aim of this study is to report additional PDCD10/CCM3 families poorly described so far which account for 10-15% of hereditary cerebral cavernous malformations. Our group investigated 87 consecutive Italian affected individuals (i.e. positive Magnetic Resonance Imaging) with multiple/familial CCM through direct sequencing and Multiplex Ligation-Dependent Probe Amplification (MLPA) analysis. We identified mutations in over 97.7% of cases, and PDCD10/CCM3 accounts for 13.1%. PDCD10/CCM3 molecular screening revealed four already known mutations and four novel ones. The mutated patients show an earlier onset of clinical manifestations as compared to CCM1/CCM2 mutated patients. The study of further families carrying mutations in PDCD10/CCM3 may help define a possible correlation between genotype and phenotype; an accurate clinical follow up of the subjects would help define more precisely whether mutations in PDCD10/CCM3 lead to a characteristic phenotype.

  4. PDCD10 gene mutations in multiple cerebral cavernous malformations.

    Directory of Open Access Journals (Sweden)

    Maria Sole Cigoli

    Full Text Available Cerebral cavernous malformations (CCMs are vascular abnormalities that may cause seizures, intracerebral haemorrhages, and focal neurological deficits. Familial form shows an autosomal dominant pattern of inheritance with incomplete penetrance and variable clinical expression. Three genes have been identified causing familial CCM: KRIT1/CCM1, MGC4607/CCM2, and PDCD10/CCM3. Aim of this study is to report additional PDCD10/CCM3 families poorly described so far which account for 10-15% of hereditary cerebral cavernous malformations. Our group investigated 87 consecutive Italian affected individuals (i.e. positive Magnetic Resonance Imaging with multiple/familial CCM through direct sequencing and Multiplex Ligation-Dependent Probe Amplification (MLPA analysis. We identified mutations in over 97.7% of cases, and PDCD10/CCM3 accounts for 13.1%. PDCD10/CCM3 molecular screening revealed four already known mutations and four novel ones. The mutated patients show an earlier onset of clinical manifestations as compared to CCM1/CCM2 mutated patients. The study of further families carrying mutations in PDCD10/CCM3 may help define a possible correlation between genotype and phenotype; an accurate clinical follow up of the subjects would help define more precisely whether mutations in PDCD10/CCM3 lead to a characteristic phenotype.

  5. Nitrogen Monitoring of West Hackberry 117 Cavern Wells

    Energy Technology Data Exchange (ETDEWEB)

    Bettin, Giorgia [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lord, David L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-02-01

    U.S. Strategic Petroleum Reserve (SPR) oil storage cavern West Hackberry 117 was tested under extended nitrogen monitoring following a successful mechanical integrity test in order to validate a newly developed hydrostatic column model to be used to differentiate between normal "tight" well behavior and small-leak behavior under nitrogen. High resolution wireline pressure and temperature data were collected during the test period and used in conjunction with the hydrostatic column model to predict the nitrogen/oil interface and the pressure along the entire fluid column from the bradenhead flange nominally at ground surface to bottom of brine pool. Results here and for other SPR caverns have shown that wells under long term nitrogen monitoring do not necessarily pressurize with a relative rate (P N2 /P brine) of 1. The theoretical relative pressure rate depends on the well configuration, pressure and the location of the nitrogen-oil interface and varies from well to well. For the case of WH117 the predicted rates were 0.73 for well A and 0.92 for well B. The measured relative pressurization rate for well B was consistent with the model prediction, while well A rate was found to be between 0.58-0.68. A number of possible reasons for the discrepancy between the model and measured rates of well A are possible. These include modeling inaccuracy, measurement inaccuracy or the possibility of the presence of a very small leak (below the latest calculated minimum detectable leak rate).

  6. Intraosseous cystic cavernous angioma with occipital skull osteolysis

    Directory of Open Access Journals (Sweden)

    Sakyo Hirai, MD

    2014-09-01

    Full Text Available Intraosseous cavernous angiomas (CAs of the skull are rare, and those cases that appear are commonly localized in the frontal bone. Computed tomography (CT and Magnetic resonance imaging (MRI typically show a well-defined intradiploic lytic mass with homogeneous enhancement. We describe an intraosseous cystic CA of the occipital skull in a 46-year-old man who presented with transient right-sided deafness and posterior cervical pain. MRI revealed a large (3.7 cm × 3.2 cm × 4.1 cm extra-axial tumor, compressing the right cerebellar hemisphere, with heterogeneous peripheral enhancement. A CT scan showed osteolytic change of the occipital skull. The tumor was totally resected via a suboccipital approach. Intraoperatively, we found a mainly cystic tumor containing xanthochromic fluid. Histologically, the tumor was diagnosed as a cavernous angioma. This is the first reported case of an intraosseous CA of the skull with cyst formation. The characteristic radiological imaging of the presented case mimicked a malignant tumor with peripheral enhancement and prominent osteolytic change.

  7. Cavernous malformation of the optic chiasm: Neuro-endoscopic removal.

    Science.gov (United States)

    Venkataramana, N K; Rao, Shailesh A V; Arun, L N; Krishna, C

    2016-01-01

    Cavernous malformations (CMs) arising from the optic nerve and chiasm are extremely rare. In large autopsy series, CMs were estimated to range from 0.02 to 0.13% in the general population. However, with introduction of MRI, these lesions were found more often than previously thought, ranging from 0.2% to 0.4%. Only 29 cases have been reported according to our knowledge. Most patients present with drop in visual acuity and visual field. Although MRI findings of cavernous malformations have been reported, they may not be diagnostic enough. Among the 29 reported, 16 underwent total resection with good results. In some, resection was complicated by damage to the surrounding neural tissue. Surgical removal is the recommended treatment to restore or preserve vision and to eliminate the risk of future hemorrhage. However, the anatomical location and eloquence of nearby neural structures can make these lesions difficult to access and remove. CMs appear to occur in every age group (range 4 months to 84 years mean-34.6 years) ith an approximately equal male to female ratio. They typically present with chiasmal apoplexy, characterized by sudden visual loss, acute headaches, retro orbital pain, and nausea.

  8. Maintenance of the contractile phenotype in corpus cavernosum smooth muscle cells by Myocardin gene therapy ameliorates erectile dysfunction in bilateral cavernous nerve injury rats.

    Science.gov (United States)

    Zhang, H-B; Wang, Z-Q; Chen, F-Z; Ding, W; Liu, W-B; Chen, Z-R; He, S-H; Wei, A-Y

    2017-07-01

    The pathophysiology of erectile dysfunction post radical prostatectomy is not clearly clarified, and the low efficacy of traditional PDE5i treatment remains a major complaint in contemporary practice. This study aimed to demonstrate phenotypic modulation in bilateral cavernous nerve injury (BCNI) rats within 7 days, and subsequently validate gene therapy with Myocardin (Mycod) by maintaining a contractile phenotype in corpus cavernosum smooth muscle cells. Initially, 36 male rats were randomly divided into BCNI and negative control (NC) groups for histological and phenotypic molecular measurements at 3, 5, and 7 days. Afterwards, an additional 30 rats received a single intra-cavernous injection of 50 μL PBS, Ad-Myocd (1 × 1011  pfu/ml) or Ad-vector for 10 animals each, namely the NC+PBS, BCNI+Ad-Myocd, and BCNI+Ad-vector groups. Finally, the validity and mechanism of Myocd transfection was explored at 21 days in vivo and 48 h in vitro. Western blotting showed canonical declines in Myocd, α-SMA, and Calponin expression, as well as elevated Osteopontin (OPN) expression, before corporeal morphological and SM-to-collagen ratio changes at day 5 after injury. Overexpression of Myocd maintained the contractile phenotype of corpus cavernosum smooth muscle cells, ameliorated bilateral cavernous nerve injury rat erectile dysfunction, as well as promoted cell contractility and suppressed proliferative capacity. Simultaneously, confocal imaging revealed up-regulation and co-localization of serum response factor in gene-transferred cells. In conclusion, our study is the first to investigate corpus cavernosum smooth muscle cells phenotypes in the early stages of cavernous injury model rats, and Myocd reversed phenotypic modulation by activating serum response factor. The experimental results demonstrated the validity of gene therapy for erectile dysfunction. © 2017 American Society of Andrology and European Academy of Andrology.

  9. Endovascular Coil Occlusion of Traumatic Intradural Aneurysm with Presentation as Carotid Cavernous Fistula

    Directory of Open Access Journals (Sweden)

    Lakshmi S P Karanam

    2014-01-01

    Full Text Available Carotid cavernous fistulae (CCF are abnormal communication between cavernous segment of the internal carotid artery and cavernous sinus. These entities are usually encountered in 0.2-0.8% of patients with traumatic skull base fractures. Traumatic cerebral aneurysms are rare and account for less than 1% of intracranial aneurysms. CCF due to ruptured intradural traumatic aneurysm is very rare and difficult to treat by surgical methods. We present one such case of a 40-year-old man with post-traumatic CCF due to a ruptured intradural aneurysm successfully treated with endovascular embolization.

  10. Acute presentation of solitary spinal epidural cavernous angioma in a child.

    Science.gov (United States)

    Khalatbari, Mahmoud Reza; Hamidi, Mehrdokht; Moharamzad, Yashar

    2013-05-01

    Solitary spinal epidural cavernous angiomas are rare lesions, especially in paediatric age group. They are infrequently considered in the differential diagnosis of spinal epidural masses in children. We report a case of solitary epidural cavernous angioma of the thoracic spine in a child presenting with acute onset of back pain and myelopathy. Magnetic resonance imaging of the thoracic spine demonstrated a posterior epidural mass at T6-T8 levels with compression of the spinal cord. Using microsurgical technique and bipolar coagulation, total excision of the lesion was achieved. Histopathological examination confirmed the diagnosis of cavernous angioma. At the five-year follow-up, there was no recurrence of the tumour.

  11. A rare case of an extra-axial cavernous angioma in the cerebellopontine angle

    Directory of Open Access Journals (Sweden)

    Rajesh K Ghanta

    2013-01-01

    Full Text Available Intracranial extra-axial cavernous angiomas are rare lesions. We report a rare case of extra-axial cavernous angioma in the cerebellopontine angle (CPA in a 50-year-old male, who presented with lower cranial nerve palsy and gait ataxia. Computed tomography (CT scan of the brain showed a hyperdense lesion in the left cerebellopontine angle. The lesion was totally excised by the retrosigmoid approach and a pathological examination confirmed the lesion to be a cavernous angioma. Following surgery, the lower cranial nerve palsy recovered significantly.

  12. A rare case of an extra-axial cavernous angioma in the cerebellopontine angle.

    Science.gov (United States)

    Ghanta, Rajesh K; Tangella, Perumallu; Koti, Kalyan; Dandamudi, Srinivas

    2013-04-01

    Intracranial extra-axial cavernous angiomas are rare lesions. We report a rare case of extra-axial cavernous angioma in the cerebellopontine angle (CPA) in a 50-year-old male, who presented with lower cranial nerve palsy and gait ataxia. Computed tomography (CT) scan of the brain showed a hyperdense lesion in the left cerebellopontine angle. The lesion was totally excised by the retrosigmoid approach and a pathological examination confirmed the lesion to be a cavernous angioma. Following surgery, the lower cranial nerve palsy recovered significantly.

  13. A Giant Scrotal Cavernous Hemangioma Extending to the Penis and Perineum: A Case Report

    Directory of Open Access Journals (Sweden)

    Osman Ergün

    2009-10-01

    Full Text Available Cavernous hemangioma is a congenital, benign vascular tumor that occurs in the deep dermis and subcutaneous tissue. Scrotal hemangiomas are rare entities and are usually diagnosed in childhood. Adult scrotal hemangiomas are also extremely rare. They are infrequently encountered in adults because they are usually removed in childhood. Urologists often face difficulties in deciding surgery to treat a genital cavernous hemangioma. Here, we report a case of scrotal cavernous hemangioma that involved the entire penis and scrotum, and extended to the perineum in a 44-year-old man, and we review the literature.

  14. A giant scrotal cavernous hemangioma extending to the penis and perineum: a case report.

    Science.gov (United States)

    Ergün, Osman; Ceylan, Berit Gokce; Armagan, Abdullah; Kapucuoglu, Nilgun; Ceyhan, A Murat; Perk, Hakki

    2009-10-01

    Cavernous hemangioma is a congenital, benign vascular tumor that occurs in the deep dermis and subcutaneous tissue. Scrotal hemangiomas are rare entities and are usually diagnosed in childhood. Adult scrotal hemangiomas are also extremely rare. They are infrequently encountered in adults because they are usually removed in childhood. Urologists often face difficulties in deciding surgery to treat a genital cavernous hemangioma. Here, we report a case of scrotal cavernous hemangioma that involved the entire penis and scrotum, and extended to the perineum in a 44-year-old man, and we review the literature.

  15. Ascending Spinal Cord Infarction Secondary to Recurrent Spinal Cord Cavernous Malformation Hemorrhage.

    Science.gov (United States)

    Huntley, Geoffrey D; Ruff, Michael W; Hicks, Stephen B; Yost, Micah D; Fulgham, Jimmy R

    2017-04-01

    We report a case of a 58-year-old Hispanic man who developed ascending paraparesis over several weeks secondary to recurrent hemorrhages and resulting in spinal cord ischemia from a low thoracic spinal cord cavernous malformation. The patient's deterioration was attributed to recurrent hemorrhage of a thoracic intramedullary cavernous malformation at T11 resulting in vascular congestion and spinal cord ischemia. The patient was found to have a heterozygous mutation on exon 13 of gene KRIT1, which was consistent with autosomal dominant familial cerebral cavernous malformations. Expedited surgical intervention potentially could have prevented this patient's progressive paraplegia. Copyright © 2017 National Stroke Association. Published by Elsevier Inc. All rights reserved.

  16. Carotid-Cavernous Fistula as a Complication of Facial Trauma: A Case Report

    Science.gov (United States)

    Lazaridou, Maria; Bourlidou, Eleni; Kontos, Konstantinos; Mangoudi, Doxa

    2014-01-01

    Posttraumatic carotid-cavernous fistula is a very rare complication that can occur in patients with craniomaxillofacial trauma. Symptoms involve headache, diplopia, ptosis of the upper lid, conjunctival chemosis, pulsating exophthalmos, and ophthalmoplegia. Diagnosis can be challenging because various pathologic entities can present with similar symptoms such as superior orbital fissure syndrome, orbital apex syndrome, retrobulbar hematoma, and cavernous sinus syndrome. However, accurate and early diagnosis is of utmost importance because treatment delay may lead to blindness or permanent neurologic deficits. In this article, a case of posttraumatic carotid-cavernous fistula that was twice misdiagnosed is presented. PMID:26269734

  17. Cavernous angioma of the cavernous sinus: imaging findings Angioma cavernoso do seio cavernoso: achados aos exames de imagem

    Directory of Open Access Journals (Sweden)

    Jose Luiz Furtado de Mendonça

    2004-12-01

    Full Text Available Cavernous angiomas (cavernomas of the cavernous sinus are uncommon, with only scattered reports in literature. Unlike their parenchymatous counterparts, they are intensely enhancing para-sellar masses, iso/hypointense in T1- and hyperintense in T2-weighted images. Differential diagnosis with para-sellar meningiomas and schwannomas can be difficult. We report three cases of this condition, describing findings of diffusion-weighted imaging in this kind of lesion for the first time in literature.Angiomas cavernosos (cavernomas do seio cavernoso são lesões incomuns, com poucos relatos na literatura especializada. Ao contrário dos cavernomas parenquimatosos, são massas para-selares intensamente captantes, isointensas a hipointensas em T1 e hiperintensas em T2 nas imagens de ressonância magnética. O diagnóstico diferencial com meningiomas e schwannomas para-selares pode ser difícil. Relatamos os achados de imagem de três casos desta entidade, descrevendo os achados da ressonância magnética ponderada em difusão neste tipo de lesão pela primeira vez na literatura.

  18. 18 December 2012 -Portuguese President of FCT M. Seabra visiting the Computing Centre with IT Department Head F. Hemmer, ATLAS experimental area with Collaboration Spokesperson F. Gianotti and A. Henriques Correia, in the LHC tunnel at Point 2 and CMS experimental area with Deputy Spokesperson J. Varela, signing an administrative agreement with Director-General R. Heuer; LIP President J. M. Gago and Delegate to CERN Council G. Barreia present.

    CERN Document Server

    Samuel Morier-Genoud

    2012-01-01

    18 December 2012 -Portuguese President of FCT M. Seabra visiting the Computing Centre with IT Department Head F. Hemmer, ATLAS experimental area with Collaboration Spokesperson F. Gianotti and A. Henriques Correia, in the LHC tunnel at Point 2 and CMS experimental area with Deputy Spokesperson J. Varela, signing an administrative agreement with Director-General R. Heuer; LIP President J. M. Gago and Delegate to CERN Council G. Barreia present.

  19. COMP-angiopoietin-1 promotes cavernous angiogenesis in a type 2 diabetic rat model.

    Science.gov (United States)

    Kim, Sun-Ouck; Lee, Hyun-Suk; Ahn, Kyuyoun; Park, Kwangsung

    2013-05-01

    Cartilage oligomeric matrix protein-angiopoietin-1 (COMP-Ang1) is an angiogenic factor for vascular angiogenesis. The aim was to investigate the effect of an intracavernosal injection of COMP-Ang1 on cavernosal angiogenesis in a diabetic rat model. Male Otsuka Long-Evans Tokushima Fatty (OLETF) rats made up the experimental group (1 yr old) and Long-Evans Tokushima Otsuka (LETO) rats made up the control group. The experimental group was divided into vehicle only, 10 µg COMP-Ang1, and 20 µg COMP-Ang1. COMP-Ang1 was injected into the corpus cavernosum of the penis. After 4 weeks, the penile tissues of the rats were obtained for immunohistochemistry and Western blot analysis. The immunoreactivity of PECAM-1 and VEGF was increased in the COMP-Ang1 group compared with the vehicle only group. Moreover, the expression of PECAM-1 and VEGF was notably augmented in the 20 µg Comp Ang-1 group. In the immunoblotting study, the expression of PECAM-1 and VEGF protein was significantly less in the OLEFT rats than in the control LETO rats. However, this expression was restored to control level after intracavernosal injection of COMP-Ang1. These results show that an intracavernosal injection of COMP-Ang1 enhances cavernous angiogenesis by structurally reinforcing the cavernosal endothelium.

  20. 13 February 2012 - World Economic Forum Founder and Executive Chairman K. Schwab and Chairperson and Co-Founder Schwab Foundation for Social Entrepreneurship H. Schwab (Mrs)in the ATLAS experimental area at LHC Point 1 with Collaboration Former Spokesperson P. Jenni; signing the guest book with CERN Director-General R. Heuer and Head of International Relations F. Pauss.

    CERN Multimedia

    Jean-Claude Gadmer

    2012-01-01

    13 February 2012 - World Economic Forum Founder and Executive Chairman K. Schwab and Chairperson and Co-Founder Schwab Foundation for Social Entrepreneurship H. Schwab (Mrs)in the ATLAS experimental area at LHC Point 1 with Collaboration Former Spokesperson P. Jenni; signing the guest book with CERN Director-General R. Heuer and Head of International Relations F. Pauss.

  1. 31st August 2011 - Government of Japan R. Chubachi, Executive Member of the Council for Science and Technology Policy, Cabinet Office, Vice Chairman, Representative Corporate Executive Officer and Member of the Board, Sony Corporation, visiting the ATLAS experimental area with Former Collaboration Spokesperson P. Jenni and Senior physicist T. Kondo.

    CERN Multimedia

    Raphaël Piguet

    2011-01-01

    31st August 2011 - Government of Japan R. Chubachi, Executive Member of the Council for Science and Technology Policy, Cabinet Office, Vice Chairman, Representative Corporate Executive Officer and Member of the Board, Sony Corporation, visiting the ATLAS experimental area with Former Collaboration Spokesperson P. Jenni and Senior physicist T. Kondo.

  2. 24 January 2012 - British Vice-Chancellor of the University of Cambridge Sir Leszek Borysiewicz signing the guest book with CERN Director-General, visiting ATLAS experimental area with Collaboration Deputy Spokesperson D. Charlton and Sm18 with engineer R. Veness.

    CERN Multimedia

    Jean-Claude Gadmer

    2012-01-01

    24 January 2012 - British Vice-Chancellor of the University of Cambridge Sir Leszek Borysiewicz signing the guest book with CERN Director-General, visiting ATLAS experimental area with Collaboration Deputy Spokesperson D. Charlton and Sm18 with engineer R. Veness.

  3. 24 February 2012 - Polish Vice-Rectors AGH University of Science and Technology Cracow visiting the ATLAS underground experimental area with Former Collaboration Spokesperson P. Jenni; Vice Rector J. Lis signs a collaboration agreement with A. Unnervik; Adviser T. Kurtyka and A. Siemko accompany the delegation throughout.

    CERN Multimedia

    Jean-Claude Gadmer

    2012-01-01

    24 February 2012 - Polish Vice-Rectors AGH University of Science and Technology Cracow visiting the ATLAS underground experimental area with Former Collaboration Spokesperson P. Jenni; Vice Rector J. Lis signs a collaboration agreement with A. Unnervik; Adviser T. Kurtyka and A. Siemko accompany the delegation throughout.

  4. 16 February 2012 - Permanent Representative of the Russian Federation to the United Nations Office and other international organisations at Geneva Ambassador A.Borodavkin signing the the guest book with CERN Director-General R. Heuer; visiting ATLAS underground experimental area with Collaboration Members O. Fedin, S. Malyukov and A. Romaniouk; throughout accompanied by Adviser T. Kurtyka.

    CERN Multimedia

    Maximilien Brice

    2012-01-01

    16 February 2012 - Permanent Representative of the Russian Federation to the United Nations Office and other international organisations at Geneva Ambassador A.Borodavkin signing the the guest book with CERN Director-General R. Heuer; visiting ATLAS underground experimental area with Collaboration Members O. Fedin, S. Malyukov and A. Romaniouk; throughout accompanied by Adviser T. Kurtyka.

  5. 13th February 2012 - German CEO Barmenia Insurance Group and Chair of the Hochschulrat Board of Governors of the Bergische Universitaet Wuppertal J. Beutelmann visiting ATLAS experimental area and signing the guest book with CERN Director-General R. Heuer and Advise R. Voss.

    CERN Multimedia

    Maximilien Brice

    2012-01-01

    13th February 2012 - German CEO Barmenia Insurance Group and Chair of the Hochschulrat Board of Governors of the Bergische Universitaet Wuppertal J. Beutelmann visiting ATLAS experimental area and signing the guest book with CERN Director-General R. Heuer and Advise R. Voss.

  6. 19 August 2013 - German Member of the Parliament of North Rhine-Westphalia M.-S. Abel MdL visiting the ATLAS experimental area with Senior physicist C. Rembser and German members of the collaboration B. Heinemann with G. Gaycken and D. Hirschbuehl.

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    19 August 2013 - German Member of the Parliament of North Rhine-Westphalia M.-S. Abel MdL visiting the ATLAS experimental area with Senior physicist C. Rembser and German members of the collaboration B. Heinemann with G. Gaycken and D. Hirschbuehl.

  7. 29 January 2009 - Italian Minister for Foreign Affairs F. Frattini, visiting the ATLAS experimental area with Director-General R. Heuer and Collaboration Spokesperson P. Jenni.

    CERN Multimedia

    Maximilien Brice

    2009-01-01

    Present during the ATLAS undegrround visit: Dr Fabiola Gianotti,ATLAS CollaborationDeputy Spokesperson and Spokesperson Designate; Dr Monica Pepe-Altarelli, LHCb Collaboration CERN Team Leader; Prof. Guido Tonelli,CMS Collaboration, Deputy Spokesperson; Prof. Roberto Petronzio, INFN President. CERN participants present in the audience during the presentations by the Director-General R. Heuer and by Prof. Antonino Zichichi, ALICE Collaboration, University of Bologna: Prof. Sergio Bertolucci,Director for Research and Scientific Computing; Prof. Felicitas Pauss, Coordinator for External Relations Coordinator; Prof. Carlo Rubbia, CERN Former Director-General, Nobel Prize in Physics 1984; Dr Jurgen Schukraft, ALICE Collaboration Spokesperson. Members of the delegation in the audience: Ambassador to the UN, H. Exc. Mr Caracciolo di Vetri; Ambassador Alain G.M. Economides,Capo di Gabinetto; Prof. Antonio Bettanini\tCons. dell’On. Ministro per le Relazioni istituzionali; On. Mario Pescante and Min. Plen Maurizio Mas...

  8. A method for the construction of strongly reduced representations of ATLAS experimental uncertainties and the application thereof to the jet energy scale

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00439393; The ATLAS collaboration

    2016-01-01

    A method is presented for the reduction of large sets of related uncertainty sources into strongly reduced representations which retain a suitable level of correlation information for use in many cases. The method provides a self-consistent means of determining whether a given analysis is sensitive to the loss of correlation information arising from the reduction procedure. The method is applied to the ATLAS Jet Energy Scale (JES) uncertainty, demonstrating that the set of 60+ independent sources can be reduced to form a representation constructed of 3 nuisance parameters. By forming a set of four such representations, it is shown that JES correlation information is retained or probed over the full parameter space to within an average of 1%. This procedure is expected to significantly reduce the computational requirements placed upon early ATLAS searches in the upcoming 2015 dataset while still providing sufficient performance and correlation structure to avoid changing the analysis results.

  9. Endoscope-assisted transsphenoidal puncture of the cavernous sinus for embolization of carotid-cavernous fistula in a neurosurgical hybrid operating suite.

    Science.gov (United States)

    Tang, Chien-Lun; Liao, Chih-Hsiang; Chen, Wen-Hsien; Shen, Shih-Chieh; Lee, Chung-Hsin; Lee, Hsu-Tung; Tsuei, Yuang-Seng

    2017-08-01

    Endovascular embolization is the treatment of choice for carotid-cavernous fistulas (CCFs), but failure to catheterize the cavernous sinus may occur as a result of vessel tortuosity, hypoplasia, or stenosis. In addition to conventional transvenous or transarterial routes, alternative approaches should be considered. The authors present a case in which a straightforward route to the CCF was accessed via transsphenoidal puncture of the cavernous sinus in a neurosurgical hybrid operating suite. This 82-year-old man presented with severe chemosis and proptosis of the right eye. Digital subtraction angiography revealed a Type B CCF with a feeding artery arising from the meningohypophyseal trunk of the right cavernous segment of the internal carotid artery. The CCF drained through a thrombosed right superior ophthalmic vein that ended deep in the orbit; there were no patent sinuses or venous plexuses connecting to the CCF. An endoscope-assisted transsphenoidal puncture created direct access to the nidus for embolization. Embolic agents were deployed through the puncture needle to achieve complete obliteration. Endoscope-assisted transsphenoidal puncture of the cavernous sinus is a feasible alternative to treat difficult-to-access CCFs in a neurosurgical hybrid operating suite.

  10. The performance of ATLAS detector

    CERN Document Server

    2011-01-01

    The ATLAS detector at the CERN Large Hadron Collider is an apparatus of unprecedented complexity, designed to probe physics in proton-proton collisions at centre-of-mass energies up to 14 TeV. It was installed in its underground cavern at the LHC during the period 2004 to 2008. Testing of individual subsystems began immediately with calibration systems and cosmic rays, and by 2008 full detector systems could be operated with the planned infrastructure, readout, and monitoring systems. Several commissioning runs of the full detector were organized in 2008 and 2009. During these runs the detector was operated continuously for several months with its readout triggered by cosmic ray muons. At the same time, regular calibrations of individual detector systems were made. In the course of these runs, signals from tens of millions of cosmic ray events were recorded. These commissioning runs continued until the first beam-beam collisions in late 2009. This volume is a collection of seven performance papers based on d...

  11. Cosmic ray runs acquired with ATLAS muon stations

    CERN Multimedia

    Cerutti, F.

    Starting in the fall 2005 several cosmic ray runs have been acquired in the ATLAS pit with six muon stations. These were three large outer and three large middle chambers of the feet sector (sector 13) that have been readout in the ATLAS cavern. In the first data taking period the trigger was based on two large scintillators (~300x30 cm2) positioned in sector 13 just below the large chambers. In this first run the precision chambers (the Monitored Drift Tubes) were operated in a close to final configuration. Typical trigger rates with this setup were of the order of 1 Hz. Several data sets of 10k events were acquired with final electronics up to the muon ROD and analysed with ATHENA-based software. These data allowed the first checks of the functionality and efficiency of the MDT stations in the ATLAS pit and the first measurement of the FE electronics noise in the ATLAS environment. A few event were also collected in a combined run with the TILE barrel calorimeter. An event display of a cosmic ray a...

  12. Preliminary Technical and Legal Evaluation of Disposing of Nonhazardous Oil Field Waste into Salt Caverns

    National Research Council Canada - National Science Library

    Veil, John

    1996-01-01

    .... These caverns are either created incidentally as a result of salt recovery or intentionally to create an underground chamber that can be used for storing hydrocarbon products or compressed air...

  13. Spinal epidural cavernous angioma: two case reports and review of the literature.

    Science.gov (United States)

    Bayri, Yaşar; Ekşi, Murat Şakir; Yalçınkaya Koç, Demet; Konya, Deniz

    2015-01-01

    Cavernous angiomas are vascular malformations that occur most frequently in the supratentorial area of the central nervous system (CNS). Spinal epidural occurrence is rare. This article describes 2 cases of spinal epidural cavernous angioma. The lesions were hypo- to isointense on T1-weighted magnetic resonance images (MRIs) and hyperintense on T2-weighted images. Both were enhanced homogenously with intravenous contrast. Total resection was achieved in both cases, and the lesions were histopathologically diagnosed as cavernous angiomas. The patients' symptoms regressed postsurgery. Although the MRI features of cavernous angiomas are well known, spinal epidural occurrence is rare and many differential diagnoses have similar clinical and imaging findings. It is important to definitively diagnose these lesions prior to surgery in order to prevent possible intraoperative complications such as massive bleeding and to maximize chances for complete resection. In addition to case descriptions, this article includes a thorough literature review to raise clinical awareness about this well-known but rare spinal entity.

  14. Transient behaviour of deep underground salt caverns; Comportement transitoire des cavites salines profondes

    Energy Technology Data Exchange (ETDEWEB)

    Karimi-Jafari, M

    2007-11-15

    This work deals with the transient behaviour of deep underground salt caverns. It has been shown that a cavern is a complex system, in which there are mechanical, thermal, chemical and hydraulic evolutions. The importance of the transient evolutions, particularly the role of the 'reverse' creep in the interpretation of the tightness test in a salt cavern is revealed. Creep is characterized by a formulation of the behaviour law which presents the advantage, in a practical point of view, to only have a reduced number of parameters while accounting of the essential of what it is observed. The initiation of the rupture in the effective traction in a salt cavern rapidly pressurized is discussed. A model fitted to a very long term behaviour (after abandonment) is developed too. In this case too, a lot of phenomena, more or less coupled, occur, when the existing literature took only into account some phenomena. (O.M.)

  15. Vascular permeability and iron deposition biomarkers in longitudinal follow-up of cerebral cavernous malformations

    DEFF Research Database (Denmark)

    Girard, Romuald; Fam, Maged D; Zeineddine, Hussein A

    2017-01-01

    OBJECTIVE Vascular permeability and iron leakage are central features of cerebral cavernous malformation (CCM) pathogenesis. The authors aimed to correlate prospective clinical behavior of CCM lesions with longitudinal changes in biomarkers of dynamic contrast-enhanced quantitative permeability...

  16. FAM222B Is Not a Likely Novel Candidate Gene for Cerebral Cavernous Malformations

    NARCIS (Netherlands)

    Spiegler, Stefanie; Kirchmaier, Bettina; Rath, Matthias; Korenke, G. Christoph; Tetzlaff, Fabian; Van De Vorst, Maartje; Neveling, Kornelia; Acker-Palmer, Amparo; Kuss, Andreas W.; Gilissen, Christian; Fischer, Andreas; Schulte-Merker, Stefan; Felbor, Ute

    2016-01-01

    Cerebral cavernous malformations (CCMs) are prevalent slow-flow vascular lesions which harbour the risk to develop intracranial haemorrhages, focal neurological deficits, and epileptic seizures. Autosomal dominantly inherited CCMs were found to be associated with heterozygous inactivating mutations

  17. Significance of Confined Cavernous Systems for Outflow Channel Water Sources, Reactivation Mechanisms and Chaos Formation

    Science.gov (United States)

    Rodriguez, J. A. P.; Sasaki, S.; Miyamoto, H.; Dohm, J. M.

    2004-03-01

    Vast amounts of water released from the confined cavernous systems played an important role in the excavation of the outflow channels. Headsource reactivation happened due to ground subsidence and subsequent increase in hydrostatic pressure.

  18. Cavernous carotid aneurysms: a new treatment paradigm in the era of flow diversion.

    Science.gov (United States)

    Raper, Daniel M S; Ding, Dale; Peterson, Eric C; Crowley, Richard W; Liu, Kenneth C; Chalouhi, Nohra; Hasan, David M; Dumont, Aaron S; Jabbour, Pascal; Starke, Robert M

    2017-02-01

    Cavernous carotid aneurysms can cause significant symptomatology through mass effect and may rupture, resulting in carotid-cavernous fistula or epistaxis. Traditional treatment options included endovascular or surgical parent vessel occlusion, or embolization; in the last decade, the development of flow-diverting stents has changed the management paradigm for these lesions. Areas covered: In this review, we summarize the natural history, clinical presentation, and evolution of treatment options for cavernous carotid aneurysms and discuss developments likely to influence treatment strategies in the future. We performed a Medline search for relevant review articles and original reports and additional searches based on review of referenced articles, abstracts, and conference presentations. Expert commentary: Long-term data are still required to fully assess the efficacy of endoluminal reconstruction using flow diversion, but this approach appears to offer an attractive therapy for many cavernous carotid aneurysms requiring intervention.

  19. Dural carotid cavernous sinus fistula presenting as isolated oculomotor nerve palsy: Case report

    Directory of Open Access Journals (Sweden)

    Şehnaz Arıcı

    2015-04-01

    Full Text Available Indirect (dural carotid cavernous fistula is formed by the connection between meningeal branches of the internal carotid artery and the cavernous sinüs, and low flow circulation with low pressure is occured. Proptosis, ophtalmoplegia, headache, scleral and conjuctival hyperemia expanding around the eyeball can be observed. A forty-eight year old female patient with a background of diabetes mellitus and hypertension was admitted with complaints of double vision. Isolated oculomotor nerve palsy was found in neurological examination and an indirect carotid cavernous fistula was revealed by digital subtraction angiography. Our case with carotid cavernous fistula as a rare cause of isolated oculomotor nerve palsy is worth to be reported.

  20. EXAMINE AND EVALUATE A PROCESS TO USE SALT CAVERNS TO RECEIVE SHIP BORNE LIQUEFIED NATURAL GAS

    Energy Technology Data Exchange (ETDEWEB)

    Michael M. McCall; William M. Bishop; D. Braxton Scherz

    2003-04-24

    The goal of the U.S. Department of Energy cooperative research project is to define, describe, and validate, a process to utilize salt caverns to receive and store the cargoes of LNG ships. The project defines the process as receiving LNG from a ship, pumping the LNG up to cavern injection pressures, warming it to cavern compatible temperatures, injecting the warmed vapor directly into salt caverns for storage, and distribution to the pipeline network. The performance of work under this agreement is based on U.S. Patent 5,511,905, and other U.S. and Foreign pending patent applications. The cost sharing participants in the research are The National Energy Technology Laboratory (U.S. Department of Energy), BP America Production Company, Bluewater Offshore Production Systems (U.S.A.), Inc., and HNG Storage, L.P. Initial results indicate that a salt cavern based receiving terminal could be built at about half the capital cost, less than half the operating costs and would have significantly higher delivery capacity, shorter construction time, and be much more secure than a conventional liquid tank based terminal. There is a significant body of knowledge and practice concerning natural gas storage in salt caverns, and there is a considerable body of knowledge and practice in handling LNG, but there has never been any attempt to develop a process whereby the two technologies can be combined. Salt cavern storage is infinitely more secure than surface storage tanks, far less susceptible to accidents or terrorist acts, and much more acceptable to the community. The project team developed conceptual designs of two salt cavern based LNG terminals, one with caverns located in Calcasieu Parish Louisiana, and the second in Vermilion block 179 about 50 miles offshore Louisiana. These conceptual designs were compared to conventional tank based LNG terminals and demonstrate superior security, economy and capacity. The potential for the development of LNG receiving terminals

  1. The superior ophthalmic vein approach for the treatment of carotid-cavernous fistulas: our first experience

    Directory of Open Access Journals (Sweden)

    Chiriac A.

    2016-06-01

    Full Text Available Complex cavernous sinus fistulae (CCF are still a technical challenge to neurovascular team. The most commonly performed treatment consists in endovascular embolization of the lesion through an arterial or venous approach. Not always these conventional routes are feasible, requiring alternative routes. We report a case of a 44-year-old woman with a complex indirect (Barrow D carotid cavernous sinus fistula treated by two interventional sessions that imposing a retrograde direct transvenous approach via the superior ophthalmic vein.

  2. Dural arteriovenous fistulas of the cavernous sinus - clinical case and treatment

    Directory of Open Access Journals (Sweden)

    Chiriac A.

    2014-06-01

    Full Text Available The purpose of our article is to present the results of our treatment of dural arteriovenous fistula of the cavernous sinus by glue embolization of the external carotid artery feeders. By this case presentation we try to clarify the clinical course, with the dural carotid cavernous fistula (CCF, characterizing a pallet of symptoms, paying special attention to radiological finding and endovascular treatment.

  3. Bleeding from a cavernous angioma mimicking rupture of a middle cerebral artery aneurysm

    Energy Technology Data Exchange (ETDEWEB)

    Krings, T. [Dept. of Neuroradiology, Univ. Hospital of the University of Technology, Aachen (Germany); Dept. of Neurosurgery, University Hospital of the University of Technology, Aachen (Germany); Mayfrank, L. [Dept. of Neurosurgery, University Hospital of the University of Technology, Aachen (Germany); Thron, A. [Dept. of Neuroradiology, Univ. Hospital of the University of Technology, Aachen (Germany)

    2001-11-01

    Cavernous angiomas and aneurysms may both present with acute cerebral haemorrhage. We present a case in which the coexistence of an unruptured aneurysm obscured the diagnosis of cerebral haemorrhage from a cavernous angioma. Although this association was presumably coincidental, this case demonstrates that obvious pathology (an angiographically proven aneurysm at the site of haemorrhage) may reduce awareness of other, possibly more common, causes of cerebral haemorrhage. (orig.)

  4. [Clinical features and surgical treatment effect of patients with cardiac cavernous hemangioma].

    Science.gov (United States)

    Yang, Q L; Tang, B; Zhou, X H; Wang, J P; Wang, H Y; Wang, S Y

    2017-09-24

    Objective: To investigate the clinical features and surgical treatment effect of patients with cardiac cavernous hemangioma. Methods: Clinical data of 9 patients (5 male, aged from 4 to 53 years old) with cardiac cavernous hemangioma, who underwent surgical treatment from November 2002 to March 2015 and the diagnosis of cardiac cavernous hemangioma was confirmed by postoperative histological examination, were retrospectively analyzed. Effects of surgical treatment were analyzed. Results: Four patients were asymptomatic (heart murmur presented in 3 patients during physical examination). Three patients presented with palpitation, chest distress, and short of breath. One patient presented with epigastric discomfort and another patient presented with intermittent fever for more than 10 months. ST and T wave changes of electrocardiogram were found in 2 patients, cardiac mass was detected in the right heart chamber in 5 patients by echocardiography, and no cardiac mass was detected the rest 4 patients. Cardiac masses were resected en bloc, then the adjacent tissues were repaired in 7 patients, and mass was partially resected due to the involvement with adjacent heart structure. No cardiac mass was found during operation in 1 case, impaired mitral valve structure was excised and postoperative pathologically confirmed as cardiac valve cavernous angioma on the excised mitral valve structure. No signs of recurrence or enlargement of cardiac cavernous hemangioma were found during the 11(10, 11)years follow up. Conclusions: There is no specific clinical feature for patients with cardiac cavernous hemangioma. It is difficult to detect the cardiac valve cavernous angioma by echocardiography before surgery. Individualized surgical treatment is associated with good clinical outcome in this patient cohort. However, the clinical features and surgical treatment effect of patients with cardiac cavernous hemangioma still need to investigate in large sample trial.

  5. Septic Cavernous Sinus Thrombosis: Case Report and Review of the Literature

    Science.gov (United States)

    Weerasinghe, Dinushi; Lueck, Christian J.

    2016-01-01

    ABSTRACT Septic cavernous sinus thrombosis is a rare but serious complication of infection of the cavernous sinuses. There are no randomised, controlled trials of management of this condition and existing reviews of the literature are somewhat dated. The authors report a case with a favourable outcome and then present the findings of a literature review of the management of this condition. Outcome data suggest that corticosteroids are of equivocal benefit whereas antibiotics and anticoagulation are beneficial. PMID:27928417

  6. Prospective Hemorrhage Rates of Cerebral Cavernous Malformations in Children and Adolescents Based on MRI Appearance.

    Science.gov (United States)

    Nikoubashman, O; Di Rocco, F; Davagnanam, I; Mankad, K; Zerah, M; Wiesmann, M

    2015-11-01

    Current classifications of cerebral cavernous malformations focus solely on morphologic aspects. Our aim was to provide a morphologic classification that reflects hemorrhage rates. We retrospectively categorized 355 cavernous malformations of 70 children and adolescents according to their morphologic appearance on MR imaging and calculated prospective hemorrhage rates on the basis of survival functions for 255 lesions in 25 patients with a radiologic observation period of >180 days. Overall, there were 199 MR imaging examinations with 1558 distinct cavernous malformation observations during a cumulative observation period of 1094.2 lesion-years. The mean hemorrhage rate of all 355 cavernous malformations was 4.5% per lesion-year. According to Kaplan-Meier survival models, Zabramski type I and II cavernous malformations had a significantly higher hemorrhage rate than type III and IV lesions. The presence of acute or subacute blood-degradation products was the strongest indicator for an increased hemorrhage risk (P = .036, Cox regression): The mean annual hemorrhage rate and mean hemorrhage-free interval for cavernous malformations with and without signs of acute or subacute blood degradation products were 23.4% and 22.6 months and 3.4% and 27.9 months, respectively. Dot-sized cavernous malformations, visible in T2* and not or barely visible in T1WI and T2WI sequences, had a mean annual hemorrhage rate of 1.3% and a mean hemorrhage-free interval of 37.8 months. It is possible to predict hemorrhage rates based on the Zabramski classification. Our findings imply a tripartite classification distinguishing lesions with and without acute or subacute blood degradation products and dot-sized cavernous malformations. © 2015 by American Journal of Neuroradiology.

  7. Disposal of NORM-Contaminated Oil Field Wastes in Salt Caverns

    Energy Technology Data Exchange (ETDEWEB)

    Blunt, D.L.; Elcock, D.; Smith, K.P.; Tomasko, D.; Viel, J.A.; and Williams, G.P.

    1999-01-21

    In 1995, the U.S. Department of Energy (DOE), Office of Fossil Energy, asked Argonne National Laboratory (Argonne) to conduct a preliminary technical and legal evaluation of disposing of nonhazardous oil field waste (NOW) into salt caverns. That study concluded that disposal of NOW into salt caverns is feasible and legal. If caverns are sited and designed well, operated carefully, closed properly, and monitored routinely, they can be a suitable means of disposing of NOW (Veil et al. 1996). Considering these findings and the increased U.S. interest in using salt caverns for NOW disposal, the Office of Fossil Energy asked Argonne to conduct further research on the cost of cavern disposal compared with the cost of more traditional NOW disposal methods and on preliminary identification and investigation of the risks associated with such disposal. The cost study (Veil 1997) found that disposal costs at the four permitted disposal caverns in the United States were comparable to or lower than the costs of other disposal facilities in the same geographic area. The risk study (Tomasko et al. 1997) estimated that both cancer and noncancer human health risks from drinking water that had been contaminated by releases of cavern contents were significantly lower than the accepted risk thresholds. Since 1992, DOE has funded Argonne to conduct a series of studies evaluating issues related to management and disposal of oil field wastes contaminated with naturally occurring radioactive material (NORM). Included among these studies were radiological dose assessments of several different NORM disposal options (Smith et al. 1996). In 1997, DOE asked Argonne to conduct additional analyses on waste disposal in salt caverns, except that this time the wastes to be evaluated would be those types of oil field wastes that are contaminated by NORM. This report describes these analyses. Throughout the remainder of this report, the term ''NORM waste'' is used to mean &apos

  8. Management of Cerebral Cavernous Malformations: From Diagnosis to Treatment

    Directory of Open Access Journals (Sweden)

    Nikolaos Mouchtouris

    2015-01-01

    Full Text Available Cerebral cavernous malformations are the most common vascular malformations and can be found in many locations in the brain. If left untreated, cavernomas may lead to intracerebral hemorrhage, seizures, focal neurological deficits, or headaches. As they are angiographically occult, their diagnosis relies on various MR imaging techniques, which detect different characteristics of the lesions as well as aiding in planning the surgical treatment. The clinical presentation and the location of the lesion are the most important factors involved in determining the optimal course of treatment of cavernomas. We concisely review the literature and discuss the advantages and limitations of each of the three available methods of treatment—microsurgical resection, stereotactic radiosurgery, and conservative management—depending on the lesion characteristics.

  9. Epileptic Seizures Induced by a Spontaneous Carotid Cavernous Fistula

    Directory of Open Access Journals (Sweden)

    Güner Koyuncu Çelik

    2016-01-01

    Full Text Available A 79-year-old woman was admitted to our emergency department with complaints of fainting and loss of consciousness three times during the past month. She was diagnosed with epilepsy and started to be treated with antiepileptic drug. Physical examination showed, in the left eye, chemosis, limited eye movements in all directions, and minimal exophthalmos as unexisting symptoms on admission developed on the sixth day. Orbital magnetic resonance imaging (MRI and digital subtraction angiography (DSA imaging revealed a carotid cavernous fistula (CCF. Epileptic attacks and ophthalmic findings previously present but diagnosed during our examinations were determined to ameliorate completely after performing the coil embolization. Based on literature, we present the first case with nontraumatic CCF manifesting with epileptic seizures and intermittent eye symptoms in the present report.

  10. CAVERNOUS HEMANGIOMALIKE CHANGES IN A CHOROIDAL MELANOMA AFTER BRACHYTHERAPY.

    Science.gov (United States)

    Lopez, Michael; Johnson, Jean G; Margo, Curtis E; Pavan, Peter R

    2016-01-01

    To describe a degenerative vascular change in a treated choroidal melanoma that clinically simulated late treatment failure. Observational case report. A 79-year-old man with choroidal melanoma treated 15 years earlier with iodine-125 brachytherapy demonstrated substantial increase in size of this once stable tumor. The eye was removed because of concern of late treatment failure. Histologically, the tumor consisted of melanocytes with no mitotic activity and virtually no Ki-67 expression. Roughly half the lesion was composed of cavernous blood-filled spaces lined by bland CD34+ and CD31+ endothelial cells. Late degenerative changes in the vasculature of treated uveal melanoma can result in tumor enlargement, which may raise clinical concerns over treatment failure and neoplastic potential.

  11. Cavernous sinus syndrome due to osteochondromatosis in a cat.

    Science.gov (United States)

    Perazzi, Anna; Bernardini, Marco; Mandara, Maria T; De Benedictis, Giulia M; De Strobel, Francesca; Zotti, Alessandro

    2013-12-01

    A 1-year-old sexually intact male Korat cat was referred for ophthalmological consultation due to anisocoria. Mydriasis with external ophthalmoplegia and absence of pupillary light responses in the right eye and nasofacial hypalgesia were seen. Cavernous sinus syndrome (CSS) was suspected. Bilateral deformities of the jaw and phalangeal bones, severe spinal pain and abnormal conformation of the lumbar spine were also present. Radiographic examination revealed several mineralised masses in the appendicular and axial skeleton, indicative of multiple cartilaginous exostoses. For further investigation of the CSS-related neurological deficits, the cat underwent computed tomography (CT) examination of the skull. CT images revealed a non-vascularised, calcified, amorphous mass originating from the right lateral skull base and superimposing on the sella turcica. Based on the severity of diffuse lesions and owing to the clinical signs of extreme pain, the cat was euthanased. A diffuse skeletal and intracranial osteochondromatosis was diagnosed histologically.

  12. Management of cerebral cavernous malformations: from diagnosis to treatment.

    Science.gov (United States)

    Mouchtouris, Nikolaos; Chalouhi, Nohra; Chitale, Ameet; Starke, Robert M; Tjoumakaris, Stavropoula I; Rosenwasser, Robert H; Jabbour, Pascal M

    2015-01-01

    Cerebral cavernous malformations are the most common vascular malformations and can be found in many locations in the brain. If left untreated, cavernomas may lead to intracerebral hemorrhage, seizures, focal neurological deficits, or headaches. As they are angiographically occult, their diagnosis relies on various MR imaging techniques, which detect different characteristics of the lesions as well as aiding in planning the surgical treatment. The clinical presentation and the location of the lesion are the most important factors involved in determining the optimal course of treatment of cavernomas. We concisely review the literature and discuss the advantages and limitations of each of the three available methods of treatment--microsurgical resection, stereotactic radiosurgery, and conservative management--depending on the lesion characteristics.

  13. Observations on vapor pressure in SPR caverns : sources.

    Energy Technology Data Exchange (ETDEWEB)

    Munson, Darrell Eugene

    2010-05-01

    The oil of the Strategic Petroleum Reserve (SPR) represents a national response to any potential emergency or intentional restriction of crude oil supply to this country, and conforms to International Agreements to maintain such a reserve. As assurance this reserve oil will be available in a timely manner should a restriction in supply occur, the oil of the reserve must meet certain transportation criteria. The transportation criteria require that the oil does not evolve dangerous gas, either explosive or toxic, while in the process of transport to, or storage at, the destination facility. This requirement can be a challenge because the stored oil can acquire dissolved gases while in the SPR. There have been a series of reports analyzing in exceptional detail the reasons for the increases, or regains, in gas content; however, there remains some uncertainty in these explanations and an inability to predict why the regains occur. Where the regains are prohibitive and exceed the criteria, the oil must undergo degasification, where excess portions of the volatile gas are removed. There are only two known sources of gas regain, one is the salt dome formation itself which may contain gas inclusions from which gas can be released during oil processing or storage, and the second is increases of the gases release by the volatile components of the crude oil itself during storage, especially if the stored oil undergoes heating or is subject to biological generation processes. In this work, the earlier analyses are reexamined and significant alterations in conclusions are proposed. The alterations are based on how the fluid exchanges of brine and oil uptake gas released from domal salt during solutioning, and thereafter, during further exchanges of fluids. Transparency of the brine/oil interface and the transfer of gas across this interface remains an important unanswered question. The contribution from creep induced damage releasing gas from the salt surrounding the cavern is

  14. CNS cavernous haemangioma: "popcorn" in the brain and spinal cord.

    Science.gov (United States)

    Hegde, A N; Mohan, S; Lim, C C T

    2012-04-01

    Cavernous haemangiomas (CH) are relatively uncommon non-shunting vascular malformations of the central nervous system and can present with seizures or with neurological deficits due to haemorrhage. Radiologists can often suggest the diagnosis of CH based on characteristic magnetic resonance imaging (MRI) features, thus avoiding further invasive procedures such as digital subtraction angiography or surgical biopsy. Although typical MRI appearance combined with the presence of multiple focal low signal lesions on T2*-weighted images or the presence of one or more developmental venous anomaly within the brain can improve the diagnostic confidence, serial imaging studies are often required if a solitary CH presents at a time when the imaging appearances had not yet matured to the typical "popcorn" appearance. Copyright © 2011 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

  15. Purely neuroendoscopic resection of an intraventricular cavernous angioma: case report.

    Science.gov (United States)

    Giannetti, Alexandre Varella

    2013-01-01

    Intraventricular cavernomas are rare and generally treated by microsurgical approach. With the advances in neuroendoscopy, intraventricular lesions have been managed by this technique. However, tumor size and vascular nature are considered restrictive factors. As far as we are concerned, there are two cases in the literature of intraventricular cavernoma resection done by neuroendoscopy. We describe a case of a man who presented with hydrocephalus secondary to a mesencephalic cavernoma and a second cavernous angioma located at the dorsum thalamus. This second lesion was successfully removed using a pure neuroendoscopic technique at the same time as a third ventriculostomy was performed. As neuroendoscopy evolves, we see that lesions considered impossible to be managed by neuroendoscopy before today are being treated with the advantages that the minimally invasive surgery offers. Georg Thieme Verlag KG Stuttgart · New York.

  16. Management of Cerebral Cavernous Malformations: From Diagnosis to Treatment

    Science.gov (United States)

    Mouchtouris, Nikolaos; Chitale, Ameet; Starke, Robert M.; Tjoumakaris, Stavropoula I.; Rosenwasser, Robert H.; Jabbour, Pascal M.

    2015-01-01

    Cerebral cavernous malformations are the most common vascular malformations and can be found in many locations in the brain. If left untreated, cavernomas may lead to intracerebral hemorrhage, seizures, focal neurological deficits, or headaches. As they are angiographically occult, their diagnosis relies on various MR imaging techniques, which detect different characteristics of the lesions as well as aiding in planning the surgical treatment. The clinical presentation and the location of the lesion are the most important factors involved in determining the optimal course of treatment of cavernomas. We concisely review the literature and discuss the advantages and limitations of each of the three available methods of treatment—microsurgical resection, stereotactic radiosurgery, and conservative management—depending on the lesion characteristics. PMID:25629087

  17. Virtual Visit to the ATLAS Control Room by the University of Genova

    CERN Multimedia

    ATLAS Experiment

    2012-01-01

    The ATLAS Virtual Visit is included in the program of the Course in Particle and Nuclear Experimental Physics at the Physics Department of the Genova University. Students are introduced to experimental techniques and instrumentation and run few experiences in the laboratory. Besides that, they visit the Department groups that are involved both in Nuclear or High Energy Particle physics experiments. In this context, the ATLAS team will open them the doors to laboratory where ~1/3 of the Pixel detector has been built and where we are currently assembling and qualifying part of the electrical services and modules for the Insertable B layer (IBL) that will be installed in 2014 in ATLAS. Students will be introduced to LHC, ATLAS and the physics program before having the possibility to meet ATLAS physicists in ATLAS control room. http://atlas-live-virtual-visit.web.cern.ch/atlas-live-virtual-visit/2012/Genova-2012.html

  18. Virtual Visit to the ATLAS Control Room by the Genova University

    CERN Multimedia

    2013-01-01

    The ATLAS Virtual Visit is included in the program of the Course in Particle and Nuclear Experimental Physics at the Physics Department of the Genova University. Students are introduced to experimental techniques and instrumentation and run few experiences in the laboratory. Besides that, they visit the Department groups that are involved both in Nuclear or High Energy Particle physics experiments. In this context, the ATLAS team will open them the doors to laboratory where ~1/3 of the Pixel detector has been built and where we are currently assembling and qualifying part of the electrical services and modules for the Insertable B layer (IBL) that will be installed in 2014 in ATLAS. Students will be introduced to LHC, ATLAS and the physics program before having the possibility to meet ATLAS physicists in ATLAS control room. http://atlas-live-virtual-visit.web.cern.ch/atlas-live-virtual-visit/2013/Genova-2013_1.html

  19. Virtual Visit to the ATLAS Control Room by the Genova University

    CERN Multimedia

    2013-01-01

    The ATLAS Virtual Visit is included in the program of the Course in Particle and Nuclear Experimental Physics at the Physics Department of the Genova University. Students are introduced to experimental techniques and instrumentation and run few experiences in the laboratory. Besides that, they visit the Department groups that are involved both in Nuclear or High Energy Particle physics experiments. In this context, the ATLAS team will open them the doors to laboratory where ~1/3 of the Pixel detector has been built and where we are currently assembling and qualifying part of the electrical services and modules for the Insertable B layer (IBL) that will be installed in 2014 in ATLAS. Students will be introduced to LHC, ATLAS and the physics program before having the possibility to meet ATLAS physicists in ATLAS control room. http://atlas-live-virtual-visit.web.cern.ch/atlas-live-virtual-visit/2013/Genova-2013_2.html

  20. Mutation prevalence of cerebral cavernous malformation genes in Spanish patients.

    Directory of Open Access Journals (Sweden)

    Rufino Mondéjar

    Full Text Available OBJECTIVE: To study the molecular genetic and clinical features of cerebral cavernous malformations (CCM in a cohort of Spanish patients. METHODS: We analyzed the CCM1, CCM2, and CCM3 genes by MLPA and direct sequencing of exons and intronic boundaries in 94 familial forms and 41 sporadic cases of CCM patients of Spanish extraction. When available, RNA studies were performed seeking for alternative or cryptic splicing. RESULTS: A total of 26 pathogenic mutations, 22 of which predict truncated proteins, were identified in 29 familial forms and in three sporadic cases. The repertoire includes six novel non-sense and frameshift mutations in CCM1 and CCM3. We also found four missense mutations, one of them located at the third NPXY motif of CCM1 and another one that leads to cryptic splicing of CCM1 exon 6. We found four genomic deletions with the loss of the whole CCM2 gene in one patient and a partial loss of CCM1and CCM2 genes in three other patients. Four families had mutations in CCM3. The results include a high frequency of intronic variants, although most of them localize out of consensus splicing sequences. The main symptoms associated to clinical debut consisted of cerebral haemorrhage, migraines and epileptic seizures. The rare co-occurrence of CCM with Noonan and Chiari syndromes and delayed menarche is reported. CONCLUSIONS: Analysis of CCM genes by sequencing and MLPA has detected mutations in almost 35% of a Spanish cohort (36% of familial cases and 10% of sporadic patients. The results include 13 new mutations of CCM genes and the main clinical symptoms that deserves consideration in molecular diagnosis and genetic counselling of cerebral cavernous malformations.

  1. Presentation, natural history, and management of carotid cavernous aneurysms.

    Science.gov (United States)

    Stiebel-Kalish, Hadas; Kalish, Yuval; Bar-On, Ruth Huna; Setton, Avi; Niimi, Yasu; Berenstein, Alejandro; Kupersmith, Mark J

    2005-11-01

    We present the largest reported cohort of carotid cavernous aneurysms (CCA), comparing the neuro-ophthalmic presentation, complications, and outcome with and without endovascular treatment. Retrospective review of 185 patients with 206 CCAs examined between 1980 and 2001 at a tertiary neuro-ophthalmology and neurovascular service. Patients' symptoms and findings at presentation were recorded and compared with those at outcome. The effect of treatment on outcome and on complication rate was analyzed using the chi test, multivariate analysis of covariance, model-selection log-linear analysis, and multinomial logistic regression. Long-term follow-up was available for 189 of 206 CCAs. Seventy-four CCAs underwent treatment (endovascular, 67 [91%]; surgical treatment, 6 [9%]), and 115 were followed for an average of 4 years, two of which required later treatment. Treatment reduced the incidence and severity of pain, even after adjusting for the severity of initial pain (F(1,192 = 9.59, P = 0.002). Treatment did not significantly affect the patient's final diplopia after adjusting for their initial diplopia (F(1, 182 = 2.01, P = 0.158). Statistical examination revealed that the treated group had a higher proportion of neurological and visual complications than people who were not treated (2(2). = 25.26, P = 0.0003). Endovascular treatment of carotid cavernous aneurysms leads to a significantly higher rate of pain resolution compared with untreated patients, even after adjusting for initial pain severity. Diplopia may not resolve after treatment. The results of this study underscore our approach indicating treatment only in cases of debilitating pain, visual loss from compression, or diplopia in primary gaze or in patients with risk factors for major complications such as pre-existing coagulopathy or sphenoid sinus erosion.

  2. Fractal Prediction of Grouting Volume for Treating Karst Caverns along a Shield Tunneling Alignment

    Directory of Open Access Journals (Sweden)

    Wen-Chieh Cheng

    2017-06-01

    Full Text Available Karst geology is common in China, and buried karst formations are widely distributed in Guangdong province. In the process of shield tunneling, the abundant water resources present in karst caverns could lead to the potential for high water ingress, and a subsequent in situ stress change-induced stratum collapse. The development and distribution of karst caverns should therefore be identified and investigated prior to shield tunnel construction. Grouting is an efficient measure to stabilize karst caverns. The total volume of karst caverns along the shield tunneling alignment, and its relationship with the required volume of grouts, should be evaluated in the preliminary design phase. Conventionally, the total volume of karst caverns is empirically estimated based on limited geological drilling hole data; however, accurate results are rarely obtained. This study investigates the hydrogeology and engineering geology of Guangzhou, the capital of Guangdong province, and determines the fractal characteristics of the karst caverns along the tunnel section of Guangzhou metro line no. 9. The karst grouting coefficients (VR were found to vary from 0.11 in the case of inadequate drilling holes to 1.1 in the case where adequate drilling holes are provided. A grouting design guideline was furthermore developed in this study for future projects in karst areas.

  3. Surgical resolution of trigeminal neuralgia due to intra-axial compression by pontine cavernous angioma.

    Science.gov (United States)

    Cenzato, Marco; Stefini, Roberto; Ambrosi, Claudia; Latronico, Nicola; Milani, Davide

    2010-01-01

    Trigeminal neuralgia is usually caused by microvascular conflict with the fifth cranial nerve in the pontocerebellar angle. Rarely is it secondary to other extra-axial or intra-axial lesions. Few cases of trigeminal neuralgia due to cavernous angiomas have been reported in the literature. This is the first report of surgical decompression of the intra-axial trigeminal nerve tract from a deep pontine cavernous angioma. A 45-year-old man came to our attention for frequent and intense left facial pain episodes compatible with trigeminal neuralgia in the V1 and V2 branches, poorly responsive to carbamazepine treatment. Magnetic resonance imaging revealed a left posterolateral pontine cavernous angioma. No neurovascular conflict was found. The cavernous angioma was surgically excised. No new neurological deficit arose and the pain episodes completely disappeared. Trigeminal neuralgia can occur occasionally secondary to the compressive effect of a pontine cavernous angioma. In this patient surgical removal of the cavernous angioma can be considered a successful and relatively safe treatment. Copyright © 2010 Elsevier Inc. All rights reserved.

  4. [Restoration of erectile function by reconstructing cavernous nerves with sural nerve grafts].

    Science.gov (United States)

    Cui, Diansheng; Hu, Liquan; Li, Shiwen; Zheng, Xinmin

    2004-05-01

    To investigate the restoration of erectile function by reconstructing cavernous nerves with sural nerve grafts. Forty-eight male Sprague-Dawley rats(3-4 m old and 300-400 g) were randomly divided into three groups: the sham-operated group (n = 16) underwent pelvic exploration without transection of the cavernous nerve; the nerve ablation group (n = 16) had a 5 mm segment of the cavernous nerve excised bilaterally; the graft group (n = 16) had a 5 mm segment of the cavernous nerve excised bilaterally, followed by immediate microsurgical reconstruction with an interposition graft of the sural nerve. The cavernous nerves of each group were electrostimulated to determine their potency after 2 and 4 months. And fluorescent retrograde-transported material Fluoro-Gold(FG) was injected into the penis. FG-labeled neuron cells in whole mounts of major pelvic ganglions were observed five days after injection. Electrical stimulation produced no erection in either the nerve ablation or the graft group, but 100% erection in the sham-operated group after 2 months. The numbers of FG-labeled neurons significantly differed between the nerve ablation group and the graft group. After 4 months erection examination showed statistical significance in the difference between the graft group and the nerve ablation group(P Cavernous nerve grafting can successfully restore erectile dysfunction in rats after surgical injury.

  5. [Dural cavernous angioma:a case report and review of the literature].

    Science.gov (United States)

    Sakakibara, Yohtaro; Taguchi, Yoshio; Nakamura, Homare; Matsumori, Takashi; Wakui, Daisuke; Kono, Takao; Aida, Yoshio

    2015-05-01

    Here, we report a case of dural cavernous angioma. A 54-year-old man presented with headache in his right frontal area for the previous few weeks. Computed tomography (CT) and magnetic resonance imaging revealed a well-demarcated extramedullary mass, 3 x 2.5cm in size, within the subdural space at the right frontal region. The mass was not enhanced on a contrast-enhanced CT scan, and heterogeneously enhanced after administration of Gd-DTPA on magnetic resonance images. Cerebral angiography revealed an avascular mass. Right frontal craniotomy was performed. On surgery, the mass was found to be mainly extramedullar, and partially intramedullar. No adhesion between the mass and the overlying dura was observed. It was removed in an en bloc fashion. The pathological diagnosis was cavernous angioma. The patient's headache was resolved soon after surgery. Cavernous angiomas are usually intramedullar in the subcortical white matter of the cerebral hemispheres;extramedullary cavernous angiomas are rare. Extramedullary dural cavernous angiomas located in the subdural space at the cerebral convexity are extremely rare. They usually present with headache or mass signs, and resemble meningioma radiologically. During surgery they are easily resected with minimal blood loss. Dural cavernous angiomas should be considered in the differential diagnosis of intradural extramedullary mass at the cerebral convexity.

  6. Carotid-cavernous fistula: current concepts in aetiology, investigation, and management.

    Science.gov (United States)

    Henderson, A D; Miller, N R

    2017-11-03

    A carotid-cavernous fistula (CCF) is an abnormal communication between arteries and veins within the cavernous sinus and may be classified as either direct or dural. Direct CCFs are characterized by a direct connection between the internal carotid artery (ICA) and the cavernous sinus, whereas dural CCFs result from an indirect connection involving cavernous arterial branches and the cavernous sinus. Direct CCFs frequently are traumatic in origin and also may be caused by rupture of an ICA aneurysm within the cavernous sinus, Ehlers-Danlos syndrome type IV, or iatrogenic intervention. Causes of dural CCFs include hypertension, fibromuscular dysplasia, Ehlers-Danlos type IV, and dissection of the ICA. Evaluation of a suspected CCF often involves non-invasive imaging techniques, including standard tonometry, pneumotonometry, ultrasound, computed tomographic scanning and angiography, and/or magnetic resonance imaging and angiography, but the gold standard for classification and diagnosis remains digital subtraction angiography. When a direct CCF is confirmed, first-line treatment is endovascular intervention, which may be accomplished using detachable balloons, coils, liquid embolic agents, or a combination of these tools. As dural CCFs often resolve spontaneously, low-risk cases may be managed conservatively. When invasive treatment is warranted, endovascular intervention or stereotactic radiosurgery may be performed. Modern endovascular techniques offer the ability to successfully treat CCFs with a low morbidity and virtually no mortality.Eye advance online publication, 3 November 2017; doi:10.1038/eye.2017.240.

  7. Simultaneous and sequential hemorrhage of multiple cerebral cavernous malformations: a case report.

    Science.gov (United States)

    Louis, Nundia; Marsh, Robert

    2016-02-09

    The etiology of cerebral cavernous malformation hemorrhage is not well understood. Causative physiologic parameters preceding hemorrhagic cavernous malformation events are often not reported. We present a case of an individual with sequential simultaneous hemorrhages in multiple cerebral cavernous malformations with a new onset diagnosis of hypertension. A 42-year-old white man was admitted to our facility with worsening headache, left facial and tongue numbness, dizziness, diplopia, and elevated blood pressure. His past medical history was significant for new onset diagnosis of hypertension and chronic seasonal allergies. Serial imaging over the ensuing 8 days revealed sequential hemorrhagic lesions. He underwent suboccipital craniotomy for resection of the lesions located in the fourth ventricle and right cerebellum. One month after surgery, he had near complete resolution of his symptoms with mild residual vertigo but symptomatic chronic hypertension. Many studies have focused on genetic and inflammatory mechanisms contributing to cerebral cavernous malformation rupture, but few have reported on the potential of hemodynamic changes contributing to cerebral cavernous malformation rupture. Systemic blood pressure changes clearly have an effect on angioma pressures. When considering the histopathological features of cerebral cavernous malformation architecture, changes in arterial pressure could cause meaningful alterations in hemorrhage propensity and patterns.

  8. The cavernous sinus in cluster headache - a quantitative structural magnetic resonance imaging study.

    Science.gov (United States)

    Arkink, Enrico B; Schoonman, Guus G; van Vliet, Jorine A; Bakels, Hannah S; Sneeboer, Marjolein Am; Haan, Joost; van Buchem, Mark A; Ferrari, Michel D; Kruit, Mark C

    2017-03-01

    Background It has been hypothesized that a constitutionally narrow cavernous sinus might predispose individuals to cluster headache. Cavernous sinus dimensions, however, have never been assessed. Methods In this case-control study, we measured the dimensions of the cavernous sinus, skull base, internal carotid and pituitary gland with high-resolution T2-weighted magnetic resonance imaging in 25 episodic, 24 chronic and 13 probable cluster headache patients, 8 chronic paroxysmal hemicrania patients and 22 headache-free controls. Dimensions were compared between groups, correcting for age, sex and transcranial diameter. Results On qualitative inspection, no relevant pathology or anatomic variants that were previously associated with cluster headache or chronic paroxysmal hemicranias were observed in the cavernous sinus or paracavernous structures. The left-to-right transcranial diameter at the temporal fossa level (mean ± SD) was larger in the headache groups (episodic cluster headache: 147.5 ± 7.3 mm, p = 0.044; chronic cluster headache: 150.2 ± 7.3 mm, p cavernous sinus and surrounding structures between headache patients and controls. Conclusion Patients with cluster headache or chronic paroxysmal hemicrania had wider skulls than headache-free controls, but the proportional dimensions of the cavernous sinus were similar.

  9. COMPUTED TOMOGRAPHIC AND ULTRASONOGRAPHIC CHARACTERISTICS OF CAVERNOUS TRANSFORMATION OF THE OBSTRUCTED PORTAL VEIN IN SMALL ANIMALS.

    Science.gov (United States)

    Specchi, Swan; Pey, Pascaline; Ledda, Gianluca; Lustgarten, Meghann; Thrall, Donald; Bertolini, Giovanna

    2015-01-01

    In humans, the process of development of collateral vessels with hepatopetal flow around the portal vein in order to bypass an obstruction is called "cavernous transformation of the portal vein." The purpose of this retrospective, cross-sectional, multicentric study was to describe presumed cavernous transformation of the portal vein in small animals with portal vein obstruction using ultrasound and multidetector-row computed tomography (MDCT). Databases from three different institutions were searched for patients with an imaging diagnosis of cavernous transformation of the portal vein secondary to portal vein obstruction of any cause. Images were retrieved and reanalyzed. With MDCT-angiography, two main portoportal collateral pathways were identified: short tortuous portoportal veins around/inside the thrombus and long portoportal collaterals bypassing the site of portal obstruction. Three subtypes of the long collaterals, often coexisting, were identified. Branches of the hepatic artery where involved in collateral circulation in nine cases. Concomitant acquired portosystemic shunts were identified in six patients. With ultrasound, cavernous transformation of the portal vein was suspected in three dogs and one cat based on visualization of multiple and tortuous vascular structures corresponding to periportal collaterals. In conclusion, the current study provided descriptive MDCT and ultrasonographic characteristics of presumed cavernous transformation of the portal vein in a sample of small animals. Cavernous transformation of the portal vein could occur as a single condition or could be concurrent with acquired portosystemic shunts. © 2015 American College of Veterinary Radiology.

  10. Risk analyses for disposing nonhazardous oil field wastes in salt caverns

    Energy Technology Data Exchange (ETDEWEB)

    Tomasko, D.; Elcock, D.; Veil, J.; Caudle, D.

    1997-12-01

    Salt caverns have been used for several decades to store various hydrocarbon products. In the past few years, four facilities in the US have been permitted to dispose nonhazardous oil field wastes in salt caverns. Several other disposal caverns have been permitted in Canada and Europe. This report evaluates the possibility that adverse human health effects could result from exposure to contaminants released from the caverns in domal salt formations used for nonhazardous oil field waste disposal. The evaluation assumes normal operations but considers the possibility of leaks in cavern seals and cavern walls during the post-closure phase of operation. In this assessment, several steps were followed to identify possible human health risks. At the broadest level, these steps include identifying a reasonable set of contaminants of possible concern, identifying how humans could be exposed to these contaminants, assessing the toxicities of these contaminants, estimating their intakes, and characterizing their associated human health risks. The contaminants of concern for the assessment are benzene, cadmium, arsenic, and chromium. These were selected as being components of oil field waste and having a likelihood to remain in solution for a long enough time to reach a human receptor.

  11. 14 February 2012 - Vice-President of the Senate of the Parliament of the Czech Republic A. Gajduskova signing the guest book with CERN Director-General R. Heuer; visiting ATLAS experimental area with Collaboration Spokesperson F. Gianotti. Ambassador Sequensova to the UN accompanies the Vice-President.

    CERN Multimedia

    Maximilien Brice

    2012-01-01

    Vice-president of the Senate of the Parliament of the Czech Republic, Alena Gajduskova was welcomed to CERN by Rolf Heuer, CERN’s director-general, on 14 and 15 February. Her time at CERN included the ATLAS Visitor Centre and underground experimental area, the LHC tunnel, the LHC superconducting-magnet test hall and the ALICE underground experimental area. She also heard a presentation on the LHC Computing Grid Project at CERN’s Computer Centre.

  12. The ATLAS Detector Control System

    CERN Document Server

    Schlenker, S; Kersten, S; Hirschbuehl, D; Braun, H; Poblaguev, A; Oliveira Damazio, D; Talyshev, A; Zimmermann, S; Franz, S; Gutzwiller, O; Hartert, J; Mindur, B; Tsarouchas, CA; Caforio, D; Sbarra, C; Olszowska, J; Hajduk, Z; Banas, E; Wynne, B; Robichaud-Veronneau, A; Nemecek, S; Thompson, PD; Mandic, I; Deliyergiyev, M; Polini, A; Kovalenko, S; Khomutnikov, V; Filimonov, V; Bindi, M; Stanecka, E; Martin, T; Lantzsch, K; Hoffmann, D; Huber, J; Mountricha, E; Santos, HF; Ribeiro, G; Barillari, T; Habring, J; Arabidze, G; Boterenbrood, H; Hart, R; Marques Vinagre, F; Lafarguette, P; Tartarelli, GF; Nagai, K; D'Auria, S; Chekulaev, S; Phillips, P; Ertel, E; Brenner, R; Leontsinis, S; Mitrevski, J; Grassi, V; Karakostas, K; Iakovidis, G.; Marchese, F; Aielli, G

    2011-01-01

    The ATLAS experiment is one of the multi-purpose experiments at the Large Hadron Collider (LHC), constructed to study elementary particle interactions in collisions of high-energy proton beams. Twelve different sub-detectors as well as the common experimental infrastructure are supervised by the Detector Control System (DCS). The DCS enables equipment supervision of all ATLAS sub-detectors by using a system of >130 server machines running the industrial SCADA product PVSS. This highly distributed system reads, processes and archives of the order of 106 operational parameters. Higher level control system layers allow for automatic control procedures, efficient error recognition and handling, and manage the communication with external systems such as the LHC. This contribution firstly describes the status of the ATLAS DCS and the experience gained during the LHC commissioning and the first physics data taking operation period. Secondly, the future evolution and maintenance constraints for the coming years an...

  13. Japan's exploration of vertical holes and subsurface caverns on the Moon and Mars

    Science.gov (United States)

    Haruyama, J.; Kawano, I.; Kubota, T.; Yoshida, K.; Kawakatsu, Y.; Kato, H.; Otsuki, M.; Watanabe, K.; Nishibori, T.; Yamamoto, Y.; Iwata, T.; Ishigami, G.; Yamada, T. T.

    2013-12-01

    Recently, gigantic vertical holes exceeding several tens of meters in diameter and depth were discovered on the Moon and Mars. Based on high-resolution image data, lunar holes and some Martian pits (called 'holes' hereafter) are probably skylights of subsurface caverns such as lava tubes or magma chambers. We are starting preparations for exploring the caverns through the vertical holes. The holes and subsurface caverns have high potential as resources for scientific studies. Various important geological and mineralogical processes could be uniquely and effectively observed inside these holes and subsurface caverns. The exposed fresh lava layers on the vertical walls of the lunar and Martian holes would provide information on volcanic eruption histories. The lava layers may also provide information on past magnetic fields of the celestial bodies. The regolith layers may be sandwiched between lava layers and may preserve volatile elements including solar wind protons that could be a clue to understanding past solar activities. Water molecules from solar winds or cometary/meteorite impacts may be stored inside the caverns because of mild temperatures there. The fresh lava materials forming the walls and floors of caverns might trap endogenic volatiles from magma eruptions that will be key materials for revealing the formation and early evolution of the Moon and Mars. Furthermore, the Martian subsurface caverns are highly expected to be life cradles where the temperatures are probably stable and that are free from ultra-violet and other cosmic rays that break chemical bonds, thus avoiding polymerization of molecules. Discovering extraterrestrial life and its varieties is one of our ultimate scientific purposes for exploring the lunar and Martian subsurface caverns. In addition to scientific interests, lunar and Martian subsurface caverns are excellent candidates for future lunar bases. We expect such caverns to have high potential due to stable temperatures; absence

  14. A new model of cavern diameter based on a validated CFD study on stirring of a highly shear-thinning fluid.

    Science.gov (United States)

    Story, Anna; Jaworski, Zdzisław

    2017-01-01

    Results of numerical simulations of momentum transfer for a highly shear-thinning fluid (0.2% Carbopol) in a stirred tank equipped with a Prochem Maxflo T type impeller are presented. The simulation results were validated using LDA data and both tangential and axial force measurements in the laminar and early transitional flow range. A good agreement between the predicted and experimental results of the local fluid velocity components was found. From the predicted and experimental values of both tangential and axial forces, the power number, Po, and thrust number, Th, were also calculated. Values of the absolute relative deviations were below 4.0 and 10.5%, respectively, for Po and Th, which confirms a satisfactory agreement with experiments. An intensive mixing zone, known as cavern, was observed near the impeller. In this zone, the local values of fluid velocity, strain rate, Metzner-Otto coefficient, shear stress and intensity of energy dissipation were all characterized by strong variability. Based on the results of experimental study a new model using non-dimensional impeller force number was proposed to predict the cavern diameter. Comparative numerical simulations were also carried out for a Newtonian fluid (water) and their results were similarly well verified using LDA measurements, as well as experimental power number values.

  15. Electrocautery-induced cavernous nerve injury in rats that mimics radical prostatectomy in humans.

    Science.gov (United States)

    Song, Lu-Jie; Zhu, Jian-Qiang; Xie, Min-Kai; Wang, Yong-Chuan; Li, Hong-Bin; Cui, Zhi-Qiang; Lu, Hong-Kai; Xu, Yue-Min

    2014-07-01

    To investigate the early and delayed effects of cavernous nerve electrocautery injury (CNEI) in a rat model, with the expectation that this model could be used to test rehabilitation therapies for erectile dysfunction (ED) after radical prostatectomy (RP). In all, 30 male Sprague-Dawley rats were randomly divided equally into two groups (15 per group). The control group received CNs exposure surgery only and the experimental group received bilateral CNEI. At 1, 4 and 16 weeks after surgery (five rats at each time point), the ratio of maximal intracavernosal pressure (ICP) to mean arterial pressure (MAP) was measured in the two groups. Neurofilament expression in the dorsal penile nerves was assessed by immunofluorescent staining and Masson's trichrome staining was used to assess the smooth muscle to collagen ratio in both groups. At the 1-week follow-up, the mean ICP/MAP was significantly lower in the CNEI group compared with the control group, at 9.94% vs 70.06% (P 0.05). The smooth muscle to collagen ratio in the CNEI group was significantly lower than in the control group at the 4- and 16-week follow-ups (P corpus cavernosum. This may provide a basis for studying potential preventative measures or treatment strategies to ameliorate ED caused by CNEI during RP. © 2013 The Authors. BJU International © 2013 BJU International.

  16. Construction of the bridge in the cavern in the Vrata tunnel (Croatia)

    Science.gov (United States)

    Garasic, Mladen; Sasa Kovacevic, Meho; Juric-Kacunic, Danijela

    2010-05-01

    In the Dinaric karst system in Croatia some 11500 speleological objects have been explored so far, more than 1000 of which were discovered during construction works. Such speleological objects without natural entrance on the terrain surface (which are called "caverns") have been discovered on the construction sites of the highways. Over the past twenty years they have been systematically investigated and treated. A special kind of remediation was conducted in the cavern's large hall of the "Vrata" tunnel on the Zagreb - Rijeka highway. Due to size, shape, cavern's position and hydrogeological parameters (fissured and karstified aquifers) within the karst system it was necessary to design and construct a 58 m bridge over the cavern. In addition, the cavern's vault had to be reinforced and stabilized, as the overburden was very thin. The beam-and -stringer grid with special anchors was used. The cavern's rehabilitation in the "Vrata" tunnel was a unique undertaking, and the bridge (without piers) is the cavern's longest bridge in the world. A speleological object of large dimensions was discovered in the "Vrata"tunnel's right tube on the Rijeka-Zagreb highway. Speleological, geotechnical, engineering geological and hydrogeological investigation works were carried out for the purpose of preservation the speleological object (cavern). On the basis of classification results of rock masses and conducted numerical analyses the support system for the cavern's vault stabilization was selected. The support system's elements include the beam-and-stringer grid constructed on the terrain's surface above the cavern, tendons and geotechnical anchors. To ensure stability of the speleological object, and to conduct the backward numerical analyses the measurement of vertical deformations from the terrain's surface along the rock's mass by means of sliding micrometers was undertaken. Backward numerical analyses combined with geotechnical measurements enable safer and more rational

  17. Advanced Underground Gas Storage Concepts: Refrigerated-Mined Cavern Storage, Final Report

    Energy Technology Data Exchange (ETDEWEB)

    none

    1998-09-30

    Over the past 40 years, cavern storage of LPG's, petrochemicals, such as ethylene and propylene, and other petroleum products has increased dramatically. In 1991, the Gas Processors Association (GPA) lists the total U.S. underground storage capacity for LPG's and related products of approximately 519 million barrels (82.5 million cubic meters) in 1,122 separate caverns. Of this total, 70 are hard rock caverns and the remaining 1,052 are caverns in salt deposits. However, along the eastern seaboard of the U.S. and the Pacific northwest, salt deposits are not available and therefore, storage in hard rocks is required. Limited demand and high cost has prevented the construction of hard rock caverns in this country for a number of years. The storage of natural gas in mined caverns may prove technically feasible if the geology of the targeted market area is suitable; and economically feasible if the cost and convenience of service is competitive with alternative available storage methods for peak supply requirements. Competing methods include LNG facilities and remote underground storage combined with pipeline transportation to the area. It is believed that mined cavern storage can provide the advantages of high delivery rates and multiple fill withdrawal cycles in areas where salt cavern storage is not possible. In this research project, PB-KBB merged advanced mining technologies and gas refrigeration techniques to develop conceptual designs and cost estimates to demonstrate the commercialization potential of the storage of refrigerated natural gas in hard rock caverns. DOE has identified five regions, that have not had favorable geological conditions for underground storage development: New England, Mid-Atlantic (NY/NJ), South Atlantic (DL/MD/VA), South Atlantic (NC/SC/GA), and the Pacific Northwest (WA/OR). PB-KBB reviewed published literature and in-house databases of the geology of these regions to determine suitability of hard rock formations for siting

  18. 19 September 2011 - Austrian State Secretary for European and International Affairs W. Waldner, signing the guest book with Head of International Relations F. Pauss; visiting CMS service cavern with Collaboration Spokesperson G. Tonelli and the LHC superconducting magnet test hall with M. Zerlauth.

    CERN Multimedia

    Benoît Jeannet

    2011-01-01

    Austrian state secretary for foreign affairs, Wolfgang Waldner, left, was welcomed to CERN by Felicitas Pauss, head of international relations at CERN, on 19 September. While at CERN, he toured the CMS control room and underground experimental service cavern, the LHC superconducting magnet test hall, and the Universe of Particles exhibition in the Globe of Science and Innovation.

  19. SUSY (ATLAS)

    CERN Document Server

    Sopczak, Andre; The ATLAS collaboration

    2017-01-01

    During the data-taking period at LHC (Run-II), several searches for supersymmetric particles were performed. The results from searches by the ATLAS collaborations are concisely reviewed. Model-independent and model-dependent limits on new particle production are set, and interpretations in supersymmetric models are given.

  20. ATLAS Story

    CERN Multimedia

    AUTHOR|(CDS)2108663

    2012-01-01

    This film produced in July 2012 explains how fundamental research connects to Society and what benefits collaborative way of working can and may generate in the future, using ATLAS Collaboration as a case study. The film is intellectually inspired by the book "Collisions and Collaboration" (OUP) by Max Boisot (ed.), see: collisionsandcollaboration.com. The film is directed by Andrew Millington (OMNI Communications)

  1. SUSY (ATLAS)

    CERN Document Server

    Sopczak, Andre; The ATLAS collaboration

    2017-01-01

    During the LHC Run-II data-taking period, several searches for supersymmetric particles were performed by the ATLAS collaboration. The results from these searches are concisely reviewed. Model-independent and model-dependent limits on new particle production are set, and interpretations in supersymmetric models are given.

  2. ATLAS Thesis Award 2017

    CERN Multimedia

    Anthony, Katarina

    2018-01-01

    Winners of the ATLAS Thesis Award were presented with certificates and glass cubes during a ceremony on 22 February, 2018. They are pictured here with Karl Jakobs (ATLAS Spokesperson), Max Klein (ATLAS Collaboration Board Chair) and Katsuo Tokushuku (ATLAS Collaboration Board Deputy Chair).

  3. ATLAS Outreach Highlights

    CERN Document Server

    Cheatham, Susan; The ATLAS collaboration

    2016-01-01

    The ATLAS outreach team is very active, promoting particle physics to a broad range of audiences including physicists, general public, policy makers, students and teachers, and media. A selection of current outreach activities and new projects will be presented. Recent highlights include the new ATLAS public website and ATLAS Open Data, the very recent public release of 1 fb-1 of ATLAS data.

  4. ATLAS Data Preservation Policy

    CERN Document Server

    The ATLAS collaboration

    2015-01-01

    The principal intent of this document is to describe the ATLAS policy ensuring that its data are maintained reliably in a form accessible to ATLAS members. A separate document describes the ATLAS policy for making its data available, and potentially useful, to scientists who are not members of ATLAS.

  5. Technical challenges of the Large Hadron Collider experiments (ATLAS and CMS).

    Science.gov (United States)

    Ball, Austin

    2015-01-13

    This review article introduces the design of the general purpose experiments ATLAS and CMS, which independently discovered the Higgs boson, showing how generic features are motivated by the characteristics needed to explore the physics landscape made accessible by the Large Hadron Collider accelerator, whose high collision rate creates an extremely challenging operating environment for instrumentation. Examples of the very different component designs chosen by the two experiment collaborations are highlighted, as an introduction to briefly describing techniques used in the construction of some of these elements and, subsequently, in the assembly of both detection systems in their respective underground caverns.

  6. Direct orbital puncture of the cavernous sinus for the treatment of a carotid-cavernous dural AV fistula with a concomitant venous/lymphatic malformation

    NARCIS (Netherlands)

    Coumou, Adriaan D.; van den Berg, René; Bot, Joost C.; Beetsma, Daan B.; Saeed, Peerooz

    2014-01-01

    A 37- year old male with a long history of a left orbital venous/lympathic malformation presented with ocular injection, increased proptosis and reduced left vision. Angiography demonstrated a carotid cavernous dural AV fistula combined with a concomitant venous/lymphatic malformation. After

  7. ATLAS - Civil Engineering - Underground Point 1

    CERN Document Server

    Jacob-Rols, J.

    2001-01-01

    Photo1-UX15 cavern April 10, 2001 Photo2-UX15 cavern April 10, 2001 Photo3-UX15 cavern April 10, 2001 Photo4-USA15 cavern April 10, 2001 Photo5-USA15 cavern April 10, 2001 Photo6-UX15 vault July 02, 2001 Photo7-UX15 cavern July 02, 2001 Photo8-USA15 cavern July 02, 2001 Photo9-USA15 cavern July 02, 2001 Photo10-USA15 Finishing works August 08, 2001 Photo11-USA15 Finishing works August 08, 2001 Photo12-Reception USA15 cervern August 08, 2001 Photo13-USA15 Finishing works August 08, 2001 Photo14-USA15 Finishing works August 08, 2001

  8. Visualization of hydraulic connections using Borehole Array around LPG Underground Storage Cavern

    Science.gov (United States)

    Shimo, M.; Mashimo, H.; Maejima, T.; Aoki, K.

    2006-12-01

    This paper presents a systematic approach to visualize the hydraulic connections within the fractured rock mass around the underground LPG storage caverns using array of water injection boreholes. By taking advantage that water injection boreholes are located so as to cover the storage caverns, a complete sketch of hydraulic conditions around the caverns, such as locations of water conducting fractures, hydraulic conductivity and groundwater pressure can be obtained. Applicability of the proposed techniques have been tested in an on-going construction project operated by JOGMEC, Japan Oil, Gas and Metals National Corporation, at Namikata, Western part of Japan. Three 26m x 30m x 485m caverns, located at 150 - 200 m below the ground surface in a granitic rock, are under construction. By systematically monitoring the pressure responses between the neighboring boreholes during drilling of total 387 boreholes around the two propane caverns, a spatial profile of the hydraulic connections and hydraulic conductivity around the caverns has been successfully obtained. Locations of localized depressurized zones created during an arch excavation have been detected by monitoring pressure in each borehole after stopping water supply to that borehole temporarily. Measurement has been conducted using each one of the 302 boreholes, one at a time. Observation shows that there is a clear correlation between total pressure drop and pressure gradient versus time curve on semi-logarithmic plot, dH/log10t, as expected by the numerical prediction. Regions where dH/log10t is larger than a certain criteria, determined by a numerical simulation for flow around a cavern in a rock with uniform hydraulic conductivity, have been evaluated as a depressurized zone caused by insufficient water supply, possibly due to existence of the high permeable zones. Separate pore pressure measurement around the caverns also supports this interpretation that a low pressure is prevailing near the borehole

  9. A noisy zygoma fracture--complication of carotid-cavernous sinus fistula: total recovery of monocular blindness and frozen-eye after endoarterial coil embolization.

    NARCIS (Netherlands)

    Bierenbroodspot, F.; Damme, P.A. van; Cruysberg, J.R.M.

    2005-01-01

    A case of a patient with a zygoma fracture in combination with a carotid-cavernous sinus fistula--an arterio-venous fistula between the internal carotid artery and the cavernous sinus--is presented. The most frequent cause is trauma, but the carotid-cavernous sinus fistula itself may have been the

  10. An object-oriented approach to deploying highly configurable Web interfaces for the ATLAS experiment

    Science.gov (United States)

    Lange, Bruno; Maidantchik, Carmen; Pommes, Kathy; Pavani, Varlen; Arosa, Breno; Abreu, Igor

    2015-12-01

    The ATLAS Technical Coordination disposes of 17 Web systems to support its operation. These applications, whilst ranging from managing the process of publishing scientific papers to monitoring radiation levels in the equipment in the experimental cavern, are constantly prone to changes in requirements due to the collaborative nature of the experiment and its management. In this context, a Web framework is proposed to unify the generation of the supporting interfaces. FENCE assembles classes to build applications by making extensive use of JSON configuration files. It relies heavily on Glance, a technology that was set forth in 2003 to create an abstraction layer on top of the heterogeneous sources that store the technical coordination data. Once Glance maps out the database modeling, records can be referenced in the configuration files by wrapping unique identifiers around double enclosing brackets. The deployed content can be individually secured by attaching clearance attributes to their description thus ensuring that view/edit privileges are granted to eligible users only. The framework also provides tools for securely writing into a database. Fully HTML5-compliant multi-step forms can be generated from their JSON description to assure that the submitted data comply with a series of constraints. Input validation is carried out primarily on the server- side but, following progressive enhancement guidelines, verification might also be performed on the client-side by enabling specific markup data attributes which are then handed over to the jQuery validation plug-in. User monitoring is accomplished by thoroughly logging user requests along with any POST data. Documentation is built from the source code using the phpDocumentor tool and made readily available for developers online. Fence, therefore, speeds up the implementation of Web interfaces and reduces the response time to requirement changes by minimizing maintenance overhead.

  11. Percutaneous Biopsy of Lesions in the Cavernous Sinus: A Systematic Review.

    Science.gov (United States)

    Dellaretti, Marcos; Almeida, Júlio César de; Martins, Warley Carvalho da Silva; Faria, Marcello Penholate

    2017-12-01

    A wide variety of lesions may develop in the cavernous sinus region, including tumors or pseudotumors of inflammatory origin. Sometimes imaging is insufficient to ascertain a pathologic diagnosis. Percutaneous biopsy performed through the foramen ovale route may aid therapeutic decision making, avoiding unnecessary open surgery when lesions are confirmed to be nonsurgical or unresectable. We conducted a systematic review to determine the efficacy of percutaneous biopsy of cavernous sinus lesions. A systematic search in PubMed, LILACS, Web of Science, and Scopus yielded 4495 potentially eligible abstracts. Fourteen studies describing 75 biopsy procedures for lesions in the cavernous sinus region were reviewed. The primary outcome measure was diagnostic success. Data were analyzed according to standard systemic review techniques. A diagnosis was obtained in 65 of the 75 cases described in the literature. Among all series, only 3 patients had permanent deficits. No individual studies reported mortality. The histopathologic evaluation revealed neoplastic diseases in 58 lesions. Meningiomas were found in 26 biopsy samples. Nonneoplastic diseases, originating from infectious, inflammatory, or deposition diseases, accounted for 6 biopsy samples. Percutaneous biopsy of cavernous sinus lesions is effective for diagnosis. Biopsy can be performed in patients with cavernous sinus masses, especially when neuroimaging fails to provide sufficient histopathologic data. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Cavernous angioma of the vestibular nerve: case report and literature review.

    Science.gov (United States)

    Adachi, Kazuhide; Yoshida, Kazunari; Akiyama, Takekazu; Kawase, Takeshi

    2008-07-01

    To date, 50 cases of cavernous angioma in the CPA have been reported, and previous reports did not describe the tumor's site of origin. We describe a case of a small, extraaxial cavernous angioma of the vestibular nerve. We also propose a reclassification system for cavernous angioma of the CPA based on the tumor's site of origin. A 39-year-old female patient had recurrent deteriorating vertigo and a right hearing disturbance. Magnetic resonance imaging revealed a cavernous angioma of the right CPA. Surgery was performed through a right lateral suboccipital approach. In the present case, the mass was attached to and covered the cisternal portion of the vestibular nerve, and it contained microvessels that were fed from the vascular plexus of the vestibular nerve. The tumor was resected en bloc, and the microvessels feeding it were cauterized. On the basis of our review of 50 cases of cavernous angioma of the CPA, we propose that these tumors can be classified according to whether they develop from the venous plexus of the dura matter or of a cranial nerve. We also suggest that the site of origin affects the postoperative symptoms.

  13. A case of dumbbell-shaped epidural cavernous angioma in the lumbar spine.

    Science.gov (United States)

    Yunoki, Masatoshi; Suzuki, Kenta; Uneda, Atsuhito; Yoshino, Kimihiro

    2015-01-01

    Most spinal cavernous haemangiomas occur in the vertebral body and purely extradural cavernous hemangiomas without any vertebral body involvement is rare and account for only 4% of all extradural spinal tumors. Dumbbell-shaped spinal cavernous angioma is extremely rare, only 10 cases have been reported in the literature. A 77-year-old female presented with a one-year history of lumbago and right-sided L3 dermatomal hypoesthesia. A dumbbell mass at the L2/3 vertebral level was identified on lumbar MRI. The lesion was irregularly shaped and isointense on T1W and hyperintense on T2W and DWI images with homogenous contrast enhancement. A presumptive diagnosis was schwannoma, but other malignant neoplasms were also considered because of its irregular shape, minimally dilated neural foramen and the involvement of the non-enhanced L3 nerve root. The patient underwent surgery with a lateral extracavitary approach. A histopathological examination revealed cavernous hemangioma. Cavernous hemangioma should be included in the differential diagnosis of dumbbell-shaped spinal tumors when the intervertebral foramina is not highly dilated and non-enhanced nerve root is identified in the tumor.

  14. Successful removal of a huge hypervascular tentorial cavernous angioma after preoperative endovascular embolization.

    Science.gov (United States)

    Yoshimura, Junichi; Tsukamoto, Yoshihiro; Sano, Masakazu; Hasegawa, Hitoshi; Nishino, Kazuhiko; Saito, Akihiko; Fukuda, Masafumi; Okamoto, Kouichirou; Fujii, Yukihiko

    2014-07-01

    The authors report a rare case of a huge hypervascular tentorial cavernous angioma treated with preoperative endovascular embolization, followed by successful gross-total removal. A 15-year-old girl presented with scintillation, diplopia, and papilledema. Computed tomography and MRI studies revealed a huge irregularly shaped tumor located in the right occipital and suboccipital regions. The tumor, which had both intra- and extradural components, showed marked enhancement and invasion of the overlying occipital bone. Angiography revealed marked tumor stain, with blood supply mainly from a large branch of the left posterior meningeal artery. Therefore, this lesion was diagnosed as a tentorium-based extraaxial tumor. For differential diagnosis, meningioma, hemangiopericytoma, and malignant skull tumor were considered. Tumor feeders were endovascularly embolized with particles of polyvinyl alcohol. On the following day, the tumor was safely gross totally removed with minimum blood loss. Histopathological examination confirmed the diagnosis of cavernous angioma. To date, there have been no reports of tentorium-based cavernous angiomas endovascularly embolized preoperatively. A tentorial cavernous angioma is most likely to show massive intraoperative bleeding. Therefore, preoperative embolization appears to be quite useful for safe maximum resection. Hence, the authors assert that the differential diagnosis of tentorium-based tumors should include tentorial cavernous angioma, for which preoperative endovascular embolization should be considered.

  15. Nature and hydrological relevance of the Shalbatana complex underground cavernous system

    Science.gov (United States)

    Rodriguez, Jose Alexis Palmero; Sasaki, Sho; Miyamoto, Hideaki

    2003-03-01

    The geomorphology of the North East trending long fractured depression between the Ganges Chasma and the Shalbatana Vallis headwater source region is examined and interpreted to be the result of collapse of part of an extensive underground cavernous system. We propose that this cavernous system undermines at least a valley, which extends from the vicinities of the Ganges Chasma and terminates in the Shalbatana Vallis headwater source region and the Aromatum Chaos. We believe that the origin of this cavernous system was related to the formation and interconnection of discrete cavernous bodies and propose a hypothesis, which involves the interaction of permafrost and intrusive magmatism to explain their formation. The Shalbatana Vallis headwater source is interpreted as produced by a Noachian impact crater and surface collapse over part of the underground cavernous system. Finally, we propose that the water sources, which were involved in the excavation of the Shalbatana and Ravis outflow channels might have included water segregated from the permafrost through interaction of intrusive magmatism and permafrost, water drained from a paleolake in the Ganges Chasma and water released from the catastrophic evacuation of confined aquifers.

  16. Cavernous sinus syndrome as the first manifestation of metastatic breast disease.

    Science.gov (United States)

    Seixas, N B; Belsuzarri, T A B; Belsuzarri, N C B; Pozetti, M; Araujo, J F M

    2017-01-01

    The cavernous sinus is a venous plexus crossed by vital neurovascular structures. Metastases to the region are uncommon and often associated with a headache, facial pain, or progressive neurological deficit in III, IV, and VI cranial nerves. The treatment options are surgery, including endoscopic approach, radiotherapy, radiosurgery, and chemotherapy. We report the case of a 26-year-old female with cavernous sinus syndrome due to breast cancer metastasis, who was subjected to chemotherapy with complete neurological recovery. A literature review was performed using the databases Bireme, Pubmed, Cochrane, Lilacs and Medline with the keywords: cavernous sinus/metastasis/surgery/radiosurgery for multiple management options review. Cavernous sinus metastases are rare, and the cavernous sinus syndrome is rarely the first sign of cancer, especially in young patients. Because the syndrome has multiple causes, the history of rapid progression and atypical image findings can arise suggesting metastatic diseases. As in our case, the image was suggestive of meningioma, however, the clinical presentation and further investigations led us to suspect as a metastatic disease. The therapeutic decision considers clinical and functional status, the extent of primary and metastatic disease, radiological study, tumor histopathology, and biological behavior. Often associated with significant symptoms and disseminated systemic disease, nowadays radiosurgery is the first and less invasive strategy, offering low risk of new deficits, clinical improvement, and good local control. The prognosis depends on early treatment and disease staging because mortality is associated with progression of cancer.

  17. Cavernous sinus invasion by pituitary macroadenomas: neuroradiological, clinical and surgical correlation

    Directory of Open Access Journals (Sweden)

    CUKIERT ARTHUR

    1998-01-01

    Full Text Available The classical imaging gold-standard for this diagnosis is the presence of tumor lateral to the carotid artery. Seventeen patients with pituitary macroadenomas with intraoperative confirmation of cavernous sinus invasion were studied with MRI. Only 8 patients had tumor lateral to the carotid artery; 13 had tumor within the carotid syphon and all lacked the ring enhancement of the medial wall of the cavernous sinus. In 10 patients, widening of the posterior double leaflets of the cavernous sinus could be. All patients were operated by the transesphenoidal route. Only one patient was cured by surgery alone. Only 3 patients disclosing the above mentioned MRI features were identified in a series of 250 patients and did not have cavernous sinus invasion. The present criteria proved to be useful in the pre-operative diagnosis of cavenous sinus invasion and patients' counselling. Pre-operative diagnosis of cavernous sinus invasion of pituitary tumors has a great impact in the management of such patients.

  18. Association between trauma and acute hemorrhage of cavernous malformations in children: report of 3 cases.

    Science.gov (United States)

    Fanous, Andrew A; Jowdy, Patrick K; Lipinski, Lindsay J; Balos, Lucia L; Li, Veetai

    2016-09-01

    OBJECTIVE Cavernous hemangiomas are benign congenital vascular abnormalities. Intracerebral cavernous hemangiomas have an appreciable risk of spontaneous hemorrhage. Little is known as to whether head trauma increases the risk of bleeding for these lesions. In this study, the authors present a case series of 3 patients with posttraumatic nonspontaneous hemorrhage of intracerebral cavernous malformations (CMs). For the first time, to the authors' knowledge, they propose that trauma might constitute a risk factor for acute hemorrhage in intracerebral cavernomas. METHODS The authors reviewed the charts of all patients with a new diagnosis of intracerebral cavernoma at their pediatric hospital between 2010 and 2014. Patients with a history of head trauma prior to presentation were subsequently studied to identify features common to these posttraumatic, hemorrhage-prone lesions. RESULTS A history of head trauma was identified in 3 of 19 cases. These 3 patients presented with seizures and/or headaches and were found to have acute hemorrhage within a cavernous hemangioma. None of these patients had any history of abnormal neurological symptoms. All 3 abnormal vascular lesions had associated developmental venous anomalies (DVAs). The 3 patients underwent resection of their respective vascular abnormalities, and the diagnosis of cavernous hemangioma was confirmed with postsurgical tissue pathology. All 3 patients had complete resolution of symptoms following complete excision of their lesions. CONCLUSIONS Trauma may represent a risk factor for acute hemorrhage in patients with CMs. The presence of associated DVAs may represent a risk factor for posttraumatic hemorrhage of cavernomas. Excision should be considered in such cases, if feasible.

  19. Endoscope-assisted resection of cavernous angioma at the foramen of Monro: a case report.

    Science.gov (United States)

    Matsumoto, Yuji; Kurozumi, Kazuhiko; Shimazu, Yousuke; Ichikawa, Tomotsugu; Date, Isao

    2016-01-01

    Intraventricular cavernous angiomas are rare pathological entities, and those located at the foramen of Monro are even rarer. We herein present a case of cavernous angioma at the foramen of Monro that was successfully treated by neuroendoscope-assisted surgical removal, and review the relevant literature. A 65-year-old woman had experienced headache and vomiting for 10 days before admission to another hospital. Magnetic resonance imaging (MRI) showed a mass at the foramen of Monro, and obstructive hydrocephalus of both lateral ventricles. The patient was then referred to our hospital. Neurological examination on admission to our hospital showed memory disturbance (Mini-Mental State Examination 20/30) and wide-based gait. A cavernous angioma at the foramen of Monro was diagnosed based on the typical popcorn-like appearance of the lesion on MRI. The lesion was completely removed by neuroendoscope-assisted transcortical surgery with the Viewsite Brain Access System (Vycor Medical Inc., Boca Raton, FL), leading to a reduction in the size of the ventricles. The resected mass was histologically confirmed to be cavernous angioma. The patient's symptoms resolved immediately and there were no postoperative complications. Minimally invasive neuroendoscope-assisted surgery was used to successfully treat a cavernous angioma at the foramen of Monro.

  20. Preliminary results of a new tool to evaluate cavernous body fibrosis following radical prostatectomy: penile elastography.

    Science.gov (United States)

    Hamidi, N; Altinbas, N K; Gokce, M I; Suer, E; Yagci, C; Baltaci, S; Turkolmez, K

    2017-09-01

    Development of cavernous tissue fibrosis due to neurovascular bundle damage during radical prostatectomy has been shown in many trials with invasive methods. In this study, we evaluated the changes in cavernous tissue elasticity by elastography in patients who underwent radical prostatectomy with or without neurovascular bundle preservation. Data from 65 patients underwent open retropubic radical prostatectomy between April 2014 and December 2015 was collected prospectively. Patients were grouped with respect to nerve-sparing status (non-, unilateral, and bilateral nerve sparing). International Index of Erectile Function scores, penile lengths, and elasticity scores were recorded at preoperative and postoperative follow-up visits (at 3rd and 6th months). The primary endpoint of the study was to evaluate the changes of the elasticity scores in all groups. Elasticity scores were measured with real-time elastography by a single experienced radiologist. Mean age, baseline total testosterone level, IIEF-5 score, elasticity scores of the cavernous body, and penile length were comparable in all groups. At postoperative 3rd and 6th months, statistically significant higher (in favor for fibrosis) mean cavernous body elasticity scores (p = 0.0001), lower mean IIEF-5 scores (p = 0.0001), and shorter penile lengths (p cavernous tissue fibrosis. © 2017 American Society of Andrology and European Academy of Andrology.

  1. 19 January 2011 - Korean Vice Minister II of Education, Science and Technology K.Chang-Kyung with Adviser R. Voss, Director-General R. Heuer and head of International Relations F. Pauss; in the LHC tunnel at Point 5 and CMS experimental cavern with Collaboration Spokesperson G. Tonelli.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    Korean vice-minister II of education, science and technology, Kim Chang-Kyung, visiting the CMS experimental area at CERN on 19 January. He also had the opportunity to view part of the LHC tunnel, as well as to visit the CERN Control Centre.

  2. A method for the construction of strongly reduced representations of ATLAS experimental uncertainties and the application thereof to the jet energy scale

    CERN Document Server

    The ATLAS collaboration

    2015-01-01

    A method is presented for the reduction of large sets of related uncertainty sources into strongly reduced representations which retain a suitable level of correlation information for use in many cases. So long as the search or measurement is not sensitive to the details of the correlations associated with the uncertainty source, this procedure can be used to reduce the complexity of the analysis. The method provides a self-consistent means of determining whether a given analysis is sensitive to the loss of correlation information arising from the reduction procedure. The method is applied to the ATLAS Jet Energy Scale (JES) uncertainty, demonstrating that the set of 67 independent sources can be strongly reduced to form a representation constructed of 3 nuisance parameters. By forming a set of four such representations, it is shown that JES correlation information is retained or probed over the full parameter space to within an average of 1%. This procedure is expected to significantly reduce the computation...

  3. A benchmark approach to hemorrhage risk management of cavernous malformations.

    Science.gov (United States)

    Kashefiolasl, Sepide; Bruder, Markus; Brawanski, Nina; Herrmann, Eva; Seifert, Volker; Tritt, Stephanie; Konczalla, Juergen

    2018-02-02

    Despite the low annual risk of hemorrhage associated with a cavernous malformation (CM) (0.6%-1.1% per year), the risk of rehemorrhage rate and severity of neurologic deficits is significantly higher; therefore, we aimed to evaluate the rupture risk of CMs depending on various factors. We retrospectively analyzed medical records of all patients with CM admitted to our institution between 1999 and April 2016. Cavernoma volume, location of the lesion, existence of a developmental venous anomaly (DVA), number of cavernomas, and patient characteristics (sex, age, hypertension, and antithrombotic therapy) were assessed. One hundred fifty-four patients with CM were included; 89 (58%) ruptured CMs were identified. In statistical univariable analysis, the existence of a DVA was significantly higher in the ruptured cavernoma group ( p DVA ( p DVA ( p DVA are associated with a higher hemorrhage risk. CM volume (≥1 cm 3 ) and the existence of a DVA were independently in accordance with the anatomical location high risk factors for CM rupture. © 2018 American Academy of Neurology.

  4. Treatment Outcome Of Seizures Associated With Intracranial Cavernous Angiomas

    Directory of Open Access Journals (Sweden)

    Nievera Conrad C

    1999-01-01

    Full Text Available Seizures are among the typical presentations of intracranial cavernous angiomas (ICA. Twenty-one patients (age range: 2 to 53 years treated for seizures associated with ICA between 1983 and 1997 were restrospectively studied to evaluate their outcome following medical or surgical intervention. The mean interval between seizure onset and initial presentation at our institution was 7.6 years. Seizures were simple partial in 3 patients, complex partial in 15 and secondarily generalized tonic-clonic in 13. The commonest site of the lesion was the temporal lobe (52%. Multiple angiomas were observed in 5 (24% patients. Seven (32% patients were medically-managed with antiepileptic therapy and 14 (68% underwent either lesionectomy with resection of the epileptogenic zone (9 patients or temporal lobectomy (5 patients. Mean follow-up time was 4 years (range: 3 months to 14 years. Of the medically-managed patients, 3 (43% remained seizure-free whereas 4 (57% continued to have seizures with an average frequency of one per day. Of the surgically-managed patients, 12 (86% became seizure-free and 2 (14% had no more than two seizures per year. Surgery appears to be extremely effective in the management of seizures associated with ICA and should receive a strong and early consideration in patients who fail medical therapy.

  5. Treatment of traumatic carotid cavernous fistulas using detachable balloons

    Energy Technology Data Exchange (ETDEWEB)

    Han, Moon Hee; Han, Joon Koo; Chang, Kee Hyun [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1989-10-15

    Since the introduction of the concept of detachable balloon technique to occlude arteriovenous fistulas, this technique has become the treatment of choice in the management of traumatic carotid cavernous fistulas (CCF). We tried the occlusion of fistula using detachable balloons in 30 consecutive cases of traumatic CCF and the result of our experience is reported. Transarterial approach with manually-tied latex balloons is tried in all cases and the fistulas were successfully occlude in 28 cases of all. In 20 cases, internal carotid artery was preserved and the arterial lumen was occluded along with fistula opening in 9 cases. In rest of 2 cases, surgical ligation was done because of procedure-related thromboembolism and incomplete occlusion of fistula. We experienced hemiparesis as a major complication in 3 cases. In one of them, the symptom developed during occlusion tolerance test, one just after insertion of guiding catheter into the internal carotid artery, and in one case 2 days after the occlusion of internal carotid artery. In one case, the procedure was performed by the direct puncture of carotid artery because of the ligation of common carotid artery by previous surgery. It is suggested that the systemic heparinization during the procedure is indispensable and starting the procedure with No 9 balloon is considered reasonable.

  6. Endothelial TLR4 and the microbiome drive cerebral cavernous malformations.

    Science.gov (United States)

    Tang, Alan T; Choi, Jaesung P; Kotzin, Jonathan J; Yang, Yiqing; Hong, Courtney C; Hobson, Nicholas; Girard, Romuald; Zeineddine, Hussein A; Lightle, Rhonda; Moore, Thomas; Cao, Ying; Shenkar, Robert; Chen, Mei; Mericko, Patricia; Yang, Jisheng; Li, Li; Tanes, Ceylan; Kobuley, Dmytro; Võsa, Urmo; Whitehead, Kevin J; Li, Dean Y; Franke, Lude; Hart, Blaine; Schwaninger, Markus; Henao-Mejia, Jorge; Morrison, Leslie; Kim, Helen; Awad, Issam A; Zheng, Xiangjian; Kahn, Mark L

    2017-05-18

    Cerebral cavernous malformations (CCMs) are a cause of stroke and seizure for which no effective medical therapies yet exist. CCMs arise from the loss of an adaptor complex that negatively regulates MEKK3-KLF2/4 signalling in brain endothelial cells, but upstream activators of this disease pathway have yet to be identified. Here we identify endothelial Toll-like receptor 4 (TLR4) and the gut microbiome as critical stimulants of CCM formation. Activation of TLR4 by Gram-negative bacteria or lipopolysaccharide accelerates CCM formation, and genetic or pharmacologic blockade of TLR4 signalling prevents CCM formation in mice. Polymorphisms that increase expression of the TLR4 gene or the gene encoding its co-receptor CD14 are associated with higher CCM lesion burden in humans. Germ-free mice are protected from CCM formation, and a single course of antibiotics permanently alters CCM susceptibility in mice. These studies identify unexpected roles for the microbiome and innate immune signalling in the pathogenesis of a cerebrovascular disease, as well as strategies for its treatment.

  7. Discovery of familial cerebral cavernous malformation in a Saudi population

    Science.gov (United States)

    Nahrir, Shahpar; Al-Hameed, Majed H; Al-Sinaidi, Omar A; Al Shakweer, Wafa

    2013-01-01

    Familial cerebral cavernous malformation is a rare entity. It has been described commonly among the Hispanic population and sparsely among the Italian, French, Swedish and Chinese populations. We discovered two families with this condition among the Saudi population for the first time. Both the index patients had a seizure as a prominent manifestation of their underlying structural lesion. One of them had recurrent attacks of bleeding in the cavernoma leading to a focal neurological deficit. The siblings and the parents of both the patients were screened using CT of the brain imaging. Two members within each family were found to have symptomatic cavernoma. A molecular genetics study revealed heterozygous KRIT1/CCM1 for a frameshift mutation in one of the patients. No detectable mutation was found in the other patient. These cases illustrate the existence of this condition beyond the commonly known geographical area of higher prevalence. Moreover, KRIT1/CCM1 might be the possible target gene that is mutated in this region. PMID:24265337

  8. Endoport-assisted microsurgical resection of cerebral cavernous malformations.

    Science.gov (United States)

    Ding, Dale; Starke, Robert M; Crowley, R Webster; Liu, Kenneth C

    2015-06-01

    The aim of this case series is to describe the surgical technique and postoperative outcomes for endoport-assisted microsurgical resection (EAMR) of cerebral cavernous malformations (CCM). Significant manipulation of subcortical white matter tracts may be necessary for the successful resection of CCM located in deep brain regions. Minimally invasive neurosurgical devices such as endoport systems can decrease disruption of the cortex and white matter tracts overlying deep-seated CCM through small cranial and dural openings. The role of endoport technology in modern CCM surgery is incompletely understood. Three patients with symptomatic CCM underwent EAMR at our institution using the BrainPath endoport system (NICO Corporation, Indianapolis, IN, USA). Complete resection was achieved in two patients. One patient with a large 4.5cm callosal CCM was left with a small residual lesion. There were no postoperative complications and all patients were functionally independent (modified Rankin Scale score 2 or less) at follow-up. Based on our initial experience with EAMR for CCM we believe the endoport can be an effective alternative to traditional retractor systems. Due to the nature of the small craniotomy and durotomy performed for endoport placement EAMR has the potential to improve surgical outcomes by reducing postoperative pain, analgesic requirements and hospital stays. Therefore, EAMR may be considered for appropriately selected CCM patients, although additional experience is necessary to improve our understanding of its role in CCM management. Copyright © 2015 Elsevier Ltd. All rights reserved.

  9. Ultrastructural analysis of vascular features in cerebral cavernous malformations.

    Science.gov (United States)

    Tanriover, Gamze; Sozen, Berna; Seker, Askin; Kilic, Turker; Gunel, Murat; Demir, Necdet

    2013-04-01

    Investigation of the structure of vascular malformations highlights the pathogenic mechanisms underlying their clinical behavior. One of the vascular malformations is called cerebral cavernous malformation (CCM). However, the ultrastructural features of the vascular malformations are not defined in detail. We aimed to investigate the ultrastructural features of CCMs using transmission (TEM), scanning (SEM) electron microscopy, and also immunohistochemistry methods with antibodies against CCM proteins such as CCM2 and CCM3. CCM tissues (n=6) microsurgically excised from patients for conventional indications. CCM2 and CCM3 were strongly detected in the vascular endothelium. However, there was a very weak immunostaining in stroma. SEM observations revealed that there were ruptures and damages in the luminal endothelium, possibly due to the damage of intercellular junctions. TEM observations also showed a few ruptures and detachments between the endothelium and basal lamina as observed with partially damages and disconnections. The architecture of pericytes showed protrusions and shrinkages. Our results suggest that the thin vessel walls of CCMs were lacking of subendothelial support and intact basal lamina underlying the endothelial cells. This study is so far the first study attempting to show human CCM lesions with SEM. We believe that an understanding of the ultrastructural features of these lesions by light and electron microscopy techniques would help to understand the pathology of these diseases. Copyright © 2012 Elsevier B.V. All rights reserved.

  10. Cerebral cavernous malformations: natural history and clinical management.

    Science.gov (United States)

    Gross, Bradley A; Du, Rose

    2015-01-01

    Cavernous malformations (CMs) are angiographically-occult clusters of dilated sinusoidal channels that may present clinically with seizures, focal neurological deficits and/or hemorrhage. Across natural history studies, the annual hemorrhage rate ranged from 1.6-3.1% per patient-year, decreasing to 0.08-0.2% per patient-year for incidental CMs and to 0.3-0.6% for the collective group of unruptured CMs. Prior hemorrhage is a significant risk factor for subsequent CM hemorrhage. Hemorrhage clustering, particularly within the first 2 years, is an established phenomenon that may confound results of natural history studies evaluating the rate of rehemorrhage. Indeed, rehemorrhage rates for hemorrhagic CMs range from 4.5-22.9% in the literature. Surgical resection is the gold standard treatment for surgically-accessible, symptomatic CMs. Incidental CMs or minimally symptomatic, surgically inaccessible eloquent lesions may be considered for observation. Stereotactic radiosurgery is a controversial treatment approach of consideration only for cases of highly aggressive, surgically inaccessible CMs.

  11. Giant cavernous hepatic hemangioma shrunk by use of sorafenib.

    Science.gov (United States)

    Yamashita, Satoyoshi; Okita, Kohsuke; Harada, Katsunori; Hirano, Atsuyoshi; Kimura, Teruaki; Kato, Akira; Okita, Kiwamu

    2013-02-01

    Here we report a case of a 76-year-old man with a giant cavernous hepatic hemangioma of more than 20 cm in diameter. Since the hepatic hemangioma was actually growing and might possibly rupture and he complained of abdominal symptoms, we decided to perform interventional therapy. First we performed transcatheter arterial embolization (TAE) of the hepatic arteries. However, since this was not sufficiently effective, we added sorafenib (600 mg/day). As a result, the tumor shrank with symptomatic improvement. Subsequently, an adverse event occurred, and we suspended the sorafenib therapy. Then, the tumor began to grow, and we resumed administering sorafenib at 400 mg/day. The tumor shrank again, and we continued the sorafenib therapy thereafter. The tumor shrinkage, although possibly induced by the effect of TAE, is considered primarily due to the effect of treatment with sorafenib, because (1) TAE did not sufficiently reduce the blood supply to the inside of the tumor; (2) other tumors shrank in the area not targeted by TAE; and (3) the tumor grew during suspension of sorafenib therapy and shrank again after resuming the treatment.

  12. Cerebral cavernous malformations with diffuse manifestation: A benign entity?

    Science.gov (United States)

    Tsutsumi, Satoshi; Ogino, Ikuko; Miyajima, Masakazu; Arai, Hajime; Ito, Masanori; Yasumoto, Yukimasa

    2016-08-15

    Cerebral cavernous malformations (CCMs) are a distinct cerebrovascular disease. A fraction of CCMs present as diffuse manifestations distributed over the cerebral hemispheres, cerebellum, and brainstem. The purpose of the present study was to explore the clinical picture of such CCMs. This study assessed the appearance of CCMs on magnetic resonance (MR) images, the presence of genetic mutations using the polymerase chain reaction method, and disease course over long-term follow-up in a total of 10 patients with diffuse CCMs. The 10 patients were Japanese and comprised 5 males and 5 females with a mean age of 48.7years. Three of them presented with seizures, two with headache and intracerebral hemorrhage, two with numbness, and one with dizziness, while the remaining two were asymptomatic. Genetic analysis revealed CCM1 mutations in four patients, CCM2 mutations in three, and a CCM3 mutation in one. In a family with 2 CCM2 patients, the appearance of sustained diffuse CCMs on MR images significantly differed between the 2 patients despite the mutation being identical. During the mean follow-up period of 13.7years, none of the 10 patients showed evidence of neurological deterioration or symptomatic hemorrhage. The appearance of their CCMs on MRI did not show significant changes. Eight patients maintained normal neurological function. CCMs with diffuse manifestation is a hereditary disease with satisfactory prognosis. Unrecognized genomic mutations may be involved in the genesis of these CCMs. Copyright © 2016 Elsevier B.V. All rights reserved.

  13. Surgical management of cavernous malformations coursing with drug resistant epilepsy

    Directory of Open Access Journals (Sweden)

    Mario Arturo Alonso-Vanegas

    2012-01-01

    Full Text Available Cerebral cavernous malformations (CM are dynamic lesions characterized by continuous size changes and repeated bleeding. When involving cortical tissue, CM pose a significant risk for the development of drug-resistant epilepsy, which is thought to be result of an altered neuronal network caused by the lesion itself and its blood degradation products. Preoperative evaluation should comprise a complete seizure history, neurological examination, epilepsy-oriented MRI, EEG, video-EEG, completed with SPECT, PET, functional MRI and/or invasive monitoring as needed. Radiosurgery shows variable rates of seizure freedom and a high incidence of complications, thus microsurgical resection remains the optimal treatment for CM coursing with drug-resistant epilepsy.Two thirds of patients reach Engel I class at three-year follow-up, regardless of lobar location. Those with secondarily generalized seizures, a higher seizure frequency, and generalized abnormalities on preoperative or postoperative EEG, show poorer outcomes, while factors such as gender, duration of epilepsy, lesion size, age, bleeding at the time of surgery, do not correlate consistently with seizure outcome. Electrocorticography and a meticulous removal of all cortical hemosiderin –beyond pure lesionectomy– reduce the risk of symptomatic recurrences.

  14. Endoscopic endonasal resection of cavernous hemangioma of the palate

    Directory of Open Access Journals (Sweden)

    Kristina Piastro

    2017-11-01

    Full Text Available Hemangiomas are a common presentation in the head and neck, but intraosseous hemangiomas are exceedingly rare and account for only 1% of bone tumors. The hard palate is a unique anatomic structure consisting of mucosa rich in minor salivary glands, and is firmly attached to the palatine process of the maxilla and the horizontal plate of the palatine bone. Neoplasms of the hard palate are extremely rare and may display unique characteristics and histologic findings. Whether benign or malignant, the therapy of choice for such tumors is surgical excision performed through a transoral approach, which carries a significant risk of oronasal and oroantral fistula formation. This paper describes the use of an endoscopic endonasal technique for resection of a rare case of a cavernous hemangioma of the hard palate. Resection of favorable benign lesions like palatal hemangiomas are more likely to be successful via this endoscopic endonasal technique which avoids the traditional transoral palatal approach and thus reduces the risk of oronasal and oroantral fistulae. No complications in the immediate postoperative nor within a 1-year follow-up period were observed.

  15. Introduction to cerebral cavernous malformation: a brief review

    Science.gov (United States)

    Kim, Jaehong

    2016-01-01

    The disease known as cerebral cavernous malformations mostly occurs in the central nervous system, and their typical histological presentations are multiple lumen formation and vascular leakage at the brain capillary level, resulting in disruption of the blood-brain barrier. These abnormalities result in severe neurological symptoms such as seizures, focal neurological deficits and hemorrhagic strokes. CCM research has identified ‘loss of function’ mutations of three ccm genes responsible for the disease and also complex regulation of multiple signaling pathways including the WNT/β-catenin pathway, TGF-β and Notch signaling by the ccm genes. Although CCM research is a relatively new and small scientific field, as CCM research has the potential to regulate systemic blood vessel permeability and angiogenesis including that of the blood-brain barrier, this field is growing rapidly. In this review, I will provide a brief overview of CCM pathogenesis and function of ccm genes based on recent progress in CCM research. [BMB Reports 2016; 49(5): 255-262] PMID:26923303

  16. Genetics of Cerebral Cavernous Malformations: Current Status and Future Prospects

    Science.gov (United States)

    Choquet, H.; Pawlikowska, L.; Lawton, M. T.; Kim, H.

    2015-01-01

    Cerebral cavernous malformations (CCM) are vascular lesions which affect up to 0.5% of the general population, predisposing to headaches, seizures, cerebral hemorrhages and focal neurological deficits. CCM occurs in both sporadic and familial forms; familial cases follow an autosomal-dominant mode of inheritance and are caused by mutations in CCM1 (KRIT1), CCM2 (MGC4607), or CCM3 (PDCD10). Somatic mutations within the three CCM genes have been identified in CCM lesions from both sporadic and familial patients. We reviewed articles published in PubMed in English prior to March 2015 and provide an update on CCM mutations and the screening strategies used to identify them. Further, we summarize the specific clinical features related to CCM genotypes. As 5 to 15% of familial CCM cases remain genetically unexplained, we also discuss future approaches to expand understanding of the genetic architecture of CCM. Finally, we discuss possible genetic modifiers of CCM disease severity and progression. Understanding the genetic architecture of CCM is essential for an earlier diagnosis of the disease, predictive testing of at-risk patients, and design of targeted medical therapies of which there are currently none available. PMID:25900426

  17. Bow-tie risk assessment combining causes and effects applied to gasoil storage in an abandoned salt cavern,

    NARCIS (Netherlands)

    Visser, K; Hendriks, D.; Wildenborg, T.; Duijne, H.

    2014-01-01

    A semi-quantitative risk assessment is presented for the storage of gas oil in depleted salt caverns in the Twente region, the Netherlands. It is based on a bow-tie model, in which an incident, leakage of gas oil from the storage system (cavern and wells), is evaluated by assessing its possible

  18. ATLAS Recordings

    CERN Multimedia

    Steven Goldfarb; Mitch McLachlan; Homer A. Neal

    Web Archives of ATLAS Plenary Sessions, Workshops, Meetings, and Tutorials from 2005 until this past month are available via the University of Michigan portal here. Most recent additions include the Trigger-Aware Analysis Tutorial by Monika Wielers on March 23 and the ROOT Workshop held at CERN on March 26-27.Viewing requires a standard web browser with RealPlayer plug-in (included in most browsers automatically) and works on any major platform. Lectures can be viewed directly over the web or downloaded locally.In addition, you will find access to a variety of general tutorials and events via the portal.Feedback WelcomeOur group is making arrangements now to record plenary sessions, tutorials, and other important ATLAS events for 2007. Your suggestions for potential recording, as well as your feedback on existing archives is always welcome. Please contact us at wlap@umich.edu. Thank you.Enjoy the Lectures!

  19. Contralateral transvenous approach and embolization with 360° guglielmi detachable coils for the treatment of cavernous sinus dural fistula.

    Science.gov (United States)

    Zenteno, Marco; Jorge, Santos-Franco; Rafael, Moscote-Salazar Luis; Raphael, AlvisMiranda Hernando; Gabriel, Alcala-Cerra; Ángel, Lee

    2015-01-01

    carotid-cavernous fistulas are spontaneours acquired connections between the carotid artery and the cavernous cavernous sinus, being classified as direct or indirect; being usually diagnosed in postmenopausal women, but are also associated with other pathoogies such as pregnancy, sinusitis and cavernous sinus thrombosis. They are clinically characterized by ophthalmological symptoms and pulsatile tinnitus. A 51-year-old woman who started her current condition about 4 years ago with pulsatile tinnitus, to which were added progressively: Pain, conjunctival erythema, right eye proptosis and the occasional headache of moderate intensity. Caotid-cavernous fistula wes diagnosed, for the technical difficulty inherent in the case was made a contralateral transvenous approach and embolization with 360° GDG coils, with successful evolution of the patient. The endovascular management of these lesions is currently possible with excellent results.

  20. Effect of Ginkgo biloba Extract (EGb-761) on Recovery of Erectile Dysfunction in Bilateral Cavernous Nerve Injury Rat Model.

    Science.gov (United States)

    Wu, Yi-No; Liao, Chun-Hou; Chen, Kuo-Chiang; Liu, Shih-Ping; Chiang, Han-Sun

    2015-05-01

    To investigate whether the therapeutic effect of Ginkgo biloba extract (GBE) in a rat model can improve erectile dysfunction after bilateral cavernous nerve injury. Forty-three male Sprague-Dawley rats underwent cavernous nerve crush injury and were randomized into 4 groups, including: vehicle only, high-dose GBE, medium-dose GBE, and low-dose GBE. Eight animals underwent sham operation. Four weeks later, erectile function was assessed by cavernous nerve electrostimulation, and penile tissue was collected for histologic analysis. Significant recovery of erectile function was observed in the high-dose GBE group in a dose-dependent manner as compared with the vehicle-only group (P corpus cavernosum after bilateral cavernous nerve injury. These implications indicate the beneficial effects of GBE use in the repair of the cavernous nerve and recovery of erectile function after radical prostatectomy. Copyright © 2015 Elsevier Inc. All rights reserved.