Integration of ITER in-vessel diagnostic components in the vacuum vessel

International Nuclear Information System (INIS)

Encheva, A.; Bertalot, L.; Macklin, B.; Vayakis, G.; Walker, C.

2009-01-01

The integration of ITER in-vessel diagnostic components is an important engineering activity. The positioning of the diagnostic components must correlate not only with their functional specifications but also with the design of the major parts of ITER torus, in particular the vacuum vessel, blanket modules, blanket manifolds, divertor, and port plugs, some of which are not yet finally designed. Moreover, the recently introduced Edge Localised Mode (ELM)/Vertical Stability (VS) coils mounted on the vacuum vessel inner wall call for not only more than a simple review of the engineering design settled down for several years now, but also for a change in the in-vessel distribution of the diagnostic components and their full impact has yet to be determined. Meanwhile, the procurement arrangement (a document defining roles and responsibilities of ITER Organization and Domestic Agency(s) (DAs) for each in-kind procurement including technical scope of work, quality assurance requirements, schedule, administrative matters) for the vacuum vessel must be finalized. These make the interface process even more challenging in terms of meeting the vacuum vessel (VV) procurement arrangement's deadline. The process of planning the installation of all the ITER diagnostics and integrating their installation into the ITER Integrated Project Schedule (IPS) is now underway. This paper covers the progress made recently on updating and issuing the interfaces of the in-vessel diagnostic components with the vacuum vessel, outlines the requirements for their attachment and summarises the installation sequence.

The TPX vacuum vessel and in-vessel components

International Nuclear Information System (INIS)

Heitzenroeder, P.; Bialek, J.; Ellis, R.; Kessel, C.; Liew, S.

1994-01-01

The Tokamak Physics Experiment (TPX) is a superconducting tokamak with double-null diverters. TPX is designed for 1,000-second discharges with the capability of being upgraded to steady state operation. High neutron yields resulting from the long duration discharges require that special consideration be given to materials and maintainability. A unique feature of the TPX is the use of a low activation, titanium alloy vacuum vessel. Double-wall vessel construction is used since it offers an efficient solution for shielding, bakeout and cooling. Contained within the vacuum vessel are the passive coil system, Plasma Facing Components (PFCs), magnetic diagnostics, and the internal control coils. All PFCs utilize carbon-carbon composites for exposed surfaces

Dust processing device for inside of vacuum vessel of thermonuclear reactor

Energy Technology Data Exchange (ETDEWEB)

Okumura, Atsushi; Tsujimura, Seiichi; Takahashi, Kenji; Ueda, Yasutoshi; Kuwata, Masayasu; Onozuka, Masaki

1995-05-02

The device of the present invention can occasionally recover dusts in a vacuum vessel of a thermonuclear reactor. In addition, fine powdery dusts are never scattered to the vacuum vessel. Namely, a processing device main body comprises a locally sealed space in the vacuum vessel. A blow-up device blows up and floats dusts accumulated in the vacuum vessel to the processing device main body. A discharge plate electrically charges the floating dusts by discharge. An electrode collects the charged dusts. Collected dusts are recovered together with a pressurized gas through a dust recovering port to the outside of the processing device. With such a constitution, it is not necessary to release the vacuum vessel to the atmosphere and evacuate after the completion of the collection of the dusts on every time when the dusts are generated as in the prior art. It is no more necessary for an operator to enter into the vacuum vessel and recover the dusts. Since fine powdery dusts are never scattered in the vacuum vessel, no undesired effects are given to exhaustion facilities and instruments of the vacuum vessel. (I.S.).

Dust processing device for inside of vacuum vessel of thermonuclear reactor

International Nuclear Information System (INIS)

Okumura, Atsushi; Tsujimura, Seiichi; Takahashi, Kenji; Ueda, Yasutoshi; Kuwata, Masayasu; Onozuka, Masaki.

1995-01-01

The device of the present invention can occasionally recover dusts in a vacuum vessel of a thermonuclear reactor. In addition, fine powdery dusts are never scattered to the vacuum vessel. Namely, a processing device main body comprises a locally sealed space in the vacuum vessel. A blow-up device blows up and floats dusts accumulated in the vacuum vessel to the processing device main body. A discharge plate electrically charges the floating dusts by discharge. An electrode collects the charged dusts. Collected dusts are recovered together with a pressurized gas through a dust recovering port to the outside of the processing device. With such a constitution, it is not necessary to release the vacuum vessel to the atmosphere and evacuate after the completion of the collection of the dusts on every time when the dusts are generated as in the prior art. It is no more necessary for an operator to enter into the vacuum vessel and recover the dusts. Since fine powdery dusts are never scattered in the vacuum vessel, no undesired effects are given to exhaustion facilities and instruments of the vacuum vessel. (I.S.)

Structural Analysis of the NCSX Vacuum Vessel

International Nuclear Information System (INIS)

Fred Dahlgren; Art Brooks; Paul Goranson; Mike Cole; Peter Titus

2004-01-01

The NCSX (National Compact Stellarator Experiment) vacuum vessel has a rather unique shape being very closely coupled topologically to the three-fold stellarator symmetry of the plasma it contains. This shape does not permit the use of the common forms of pressure vessel analysis and necessitates the reliance on finite element analysis. The current paper describes the NCSX vacuum vessel stress analysis including external pressure, thermal, and electro-magnetic loading from internal plasma disruptions and bakeout temperatures of up to 400 degrees centigrade. Buckling and dynamic loading conditions are also considered

ITER cryostat main chamber and vacuum vessel pressure suppression system design

International Nuclear Information System (INIS)

Ito, Akira; Nakahira, Masataka; Takahashi, Hiroyuki; Tada, Eisuke; Nakashima, Yoshitane; Ueno, Osamu

1999-03-01

Design of Cryostat Main Chamber and Vacuum Vessel Pressure Suppression System (VVPS) of International Thermonuclear Experimental Reactor (ITER) has been conducted. The cryostat is a cylindrical vessel that includes in-vessel component such as vacuum vessel, superconducting toroidal coils and poloidal coils. This cryostat provides the adiabatic vacuum about 10 -4 Pa for the superconducting coils operating at 4 K and forms the second confinement barrier to tritium. The adiabatic vacuum is to reduce thermal loads applied to the superconducting coils and their supports so as to keep their temperature 4 K. The VVPS consists of a suppression tank located under the lower bio-shield and 4 relief pipes to connect the vacuum vessel and the suppression tank. The VVPS is to keep the maximum pressure rise of the vacuum vessel below the design value of 0.5 MPa in case of the in-vessel LOCA (water spillage from in-vessel component). The spilled water and steam are lead to the suppression tank through the relief pipes when the internal pressure of vacuum vessel is over 0.2 MPa, and then the internal pressure is kept below 0.5 MPa. This report summarizes the structural design of the cryostat main chamber and pressure suppression system, together with their fabrication and installation. (author)

ITER cryostat main chamber and vacuum vessel pressure suppression system design

Energy Technology Data Exchange (ETDEWEB)

Ito, Akira; Nakahira, Masataka; Takahashi, Hiroyuki; Tada, Eisuke [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Nakashima, Yoshitane; Ueno, Osamu

1999-03-01

Design of Cryostat Main Chamber and Vacuum Vessel Pressure Suppression System (VVPS) of International Thermonuclear Experimental Reactor (ITER) has been conducted. The cryostat is a cylindrical vessel that includes in-vessel component such as vacuum vessel, superconducting toroidal coils and poloidal coils. This cryostat provides the adiabatic vacuum about 10{sup -4} Pa for the superconducting coils operating at 4 K and forms the second confinement barrier to tritium. The adiabatic vacuum is to reduce thermal loads applied to the superconducting coils and their supports so as to keep their temperature 4 K. The VVPS consists of a suppression tank located under the lower bio-shield and 4 relief pipes to connect the vacuum vessel and the suppression tank. The VVPS is to keep the maximum pressure rise of the vacuum vessel below the design value of 0.5 MPa in case of the in-vessel LOCA (water spillage from in-vessel component). The spilled water and steam are lead to the suppression tank through the relief pipes when the internal pressure of vacuum vessel is over 0.2 MPa, and then the internal pressure is kept below 0.5 MPa. This report summarizes the structural design of the cryostat main chamber and pressure suppression system, together with their fabrication and installation. (author)

Vacuum distilling vessel

Energy Technology Data Exchange (ETDEWEB)

Reik, H

1928-12-27

Vacuum distilling vessel for mineral oil and the like, characterized by the ring-form or polyconal stiffeners arranged inside, suitably eccentric to the casing, being held at a distance from the casing by connecting members of such a height that in the resulting space if necessary can be arranged vapor-distributing pipes and a complete removal of the residue is possible.

Vacuum vessel of thermonuclear device and manufacturing method thereof

International Nuclear Information System (INIS)

Kurita, Genichi; Nagashima, Keisuke; Uchida, Takaho; Shibui, Masanao; Ebisawa, Katsuyuki; Nakagawa, Satoshi.

1997-01-01

The present invention provides a vacuum vessel of a thermonuclear device using, as a material of a plasma vacuum vessel, a material to be less activated and having excellent strength as well as a manufacturing method thereof. Namely, the vacuum vessel is made of titanium or a titanium alloy. In addition, a liner layer comprising a manganese alloy, nickel alloy, nickel-chromium alloy or aluminum or aluminum alloy is formed. With such a constitution, the wall substrate made of titanium or a titanium alloy can be isolated by the liner from hydrogen or plasmas. As a result, occlusion of hydrogen to titanium or the titanium alloy can be prevented thereby enabling to prevent degradation of the material of the wall substrate of the vacuum vessel. In addition, since the liner layer has relatively high electric resistance, a torus circumferential resistance value required for plasma ignition can be ensured by using it together with the vessel wall made of titanium alloy. (I.S.)

Baking of SST-1 vacuum vessel modules and sectors

International Nuclear Information System (INIS)

Pathan, Firozkhan S; Khan, Ziauddin; Yuvakiran, Paravastu; George, Siju; Ramesh, Gattu; Manthena, Himabindu; Shah, Virendrakumar; Raval, Dilip C; Thankey, Prashant L; Dhanani, Kalpesh R; Pradhan, Subrata

2012-01-01

SST-1 Tokamak is a steady state super-conducting tokamak for plasma discharge of 1000 sec duration. The plasma discharge of such long time duration can be obtained by reducing the impurities level, which will be possible only when SST-1 vacuum chamber is pumped to ultra high vacuum. In order to achieve UHV inside the chamber, the baking of complete vacuum chamber has to be carried out during pumping. For this purpose the C-channels are welded inside the vacuum vessel. During baking of vacuum vessel, these welded channels should be helium leak tight. Further, these U-channels will be in accessible under operational condition of SST-1. So, it will not possible to repair if any leak is developed during experiment. To avoid such circumstances, a dedicated high vacuum chamber is used for baking of the individual vacuum modules and sectors before assembly so that any fault during welding of the channels will be obtained and repaired. This paper represents the baking of vacuum vessel modules and sectors and their temperature distribution along the entire surface before assembly.

Fabrication of the vacuum vessel for JT-60 machine upgrade

International Nuclear Information System (INIS)

Uchikawa, T.; Takanabe, K.; Tsujimura, S.; Ue, K.; Oka, K.; Kuri, S.; Ioki, K.; Namiki, K.; Suzuki, Y.; Horliike, H.; Ninomiya, H.; Yamamoto, M.; Neyatani, Y.; Ando, T.; Matsukawa, M.

1992-01-01

The JT-60 tokamak was upgraded to double the plasma current to 6 MA. In the JT-60 machine upgrade (JT-60U), the vacuum vessel and poloidal field (PF) coils were renewed. The new vacuum vessel features a three-dimensionally curved, thin double-skin torus with multi-arc D-shaped cross section. The double-skin structure is strengthened with square pipes placed in between the outer and inner skins. Fabrication and site installation of the vessel was smoothly completed in February, 1991. This paper describes an overview of the JT-60U vacuum vessel construction

Vacuum vessel for the tandem Mirror Fusion Test Facility

International Nuclear Information System (INIS)

Gerich, J.W.

1986-01-01

In 1980, the US Department of Energy gave the Lawrence Livermore National Laboratory approval to design and build a tandem Mirror Fusion Test Facility (MFTF-B) to support the goals of the National Mirror Program. We designed the MFTF-B vacuum vessel both to maintain the required ultrahigh vacuum environment and to structurally support the 42 superconducting magnets plus auxiliary internal and external equipment. During our design work, we made extensive use of both simple and complex computer models to arrive at a cost-effective final configuration. As part of this work, we conducted a unique dynamic analysis to study the interaction of the 32,000-tonne concrete-shielding vault with the 2850-tonne vacuum vessel system. To maintain a vacuum of 2 x 10 -8 torr during the physics experiments inside the vessel, we designed a vacuum pumping system of enormous capacity. The vacuum vessel (4200-m 3 internal volume) has been fabricated and erected, and acceptance tests have been completed at the Livermore site. The rest of the machine has been assembled, and individual systems have been successfully checked. On October 1, 1985, we began a series of integrated engineering tests to verify the operation of all components as a complete system

Device for supporting the vacuum vessel of a thermonuclear device

International Nuclear Information System (INIS)

Sato, Hiroshi.

1980-01-01

Purpose: To hold a vacuum vessel securely at a predetermined position. Constitution: A vacuum vessel is supported on its one side to the standard mounting location of a support frame by way of a pin junction. The vacuum vessel is provided at its upper and lower positions with movable mounting portions, which are connected by way of connecting rods to fixed mounting locations on the upper and lower frames. The fixed mounting locations are disposed on a vertical plane including the axis of the torus center. This arrangement enables to hold even a large vacuum vessel at an exact predetermined position even under high temperature conditions without limiting the container's thermal expansion relative to the changes in temperature, thereby providing an extremely high rigidity against electromagnetic forces, earthquakes, etc. (Furukawa, Y.)

Design and construction of Alborz tokamak vacuum vessel system

International Nuclear Information System (INIS)

Mardani, M.; Amrollahi, R.; Koohestani, S.

2012-01-01

Highlights: ► The Alborz tokamak is a D-shape cross section tokamak that is under construction in Amirkabir University of Technology. ► As one of the key components for the device, the vacuum vessel can provide ultra-high vacuum and clean environment for the plasma operation. ► A limiter is a solid surface which defines the edge of the plasma and designed to protect the wall from the plasma, localizes the plasma–surface interaction and localizes the particle recycling. ► Structural analyses were confirmed by FEM model for dead weight, vacuum pressure and plasma disruptions loads. - Abstract: The Alborz tokamak is a D-shape cross section tokamak that is under construction in Amirkabir University of Technology. At the heart of the tokamak is the vacuum vessel and limiter which collectively are referred to as the vacuum vessel system. As one of the key components for the device, the vacuum vessel can provide ultra-high vacuum and clean environment for the plasma operation. The VV systems need upper and lower vertical ports, horizontal ports and oblique ports for diagnostics, vacuum pumping, gas puffing, and maintenance accesses. A limiter is a solid surface which defines the edge of the plasma and designed to protect the wall from the plasma, localizes the plasma–surface interaction and localizes the particle recycling. Basic structure analyses were confirmed by FEM model for dead weight, vacuum pressure and plasma disruptions loads. Stresses at general part of the VV body are lower than the structure material allowable stress (117 MPa) and this analysis show that the maximum stresses occur near the gravity support, and is about 98 MPa.

Vacuum vessels for the LHC magnets arrive at CERN

CERN Multimedia

2001-01-01

The first batch of pre-series vacuum vessels for the LHC dipole magnets has just been delivered to CERN. The vessels are components of the cryostats and will provide the thermal insulation for the superconducting magnets. The first batch of vacuum vessels for the LHC dipole magnets with the team taking part at CERN in ordering and installing them. Left to right : Claude Hauviller, Monique Dupont, Lloyd Williams, Franck Gavin, Alain Jacob, Christophe Vuitton, Davide Bozzini, Laure Sandri, Mikael Sjoholm and André de Saever. In 2006 all that will be seen of the LHC superconducting dipoles in the LHC tunnel will be a line of over 1230 blue cylindrical vacuum vessels. Ten vessels, each weighing 4 tonnes, are already at CERN. On 6 July the first batch of pre-series vessels reached the Lab-oratory from the firm SIMIC Spa whose works are near Savona in north-western Italy. Despite appearances, these 15-metre long, 1-metre diameter blue tubes are much more sophisticated than sections of a run-of-the-mill...

Analysis of effective electrical parameters for CFETR vacuum vessel

Energy Technology Data Exchange (ETDEWEB)

Liu, Xufeng; Xu, Weiwei, E-mail: wwxu@ipp.ac.cn; Du, Shuangsong; Zheng, Jinxing

2016-11-15

Highlights: • The eddy current distribution and variation of CFETR vacuum vessel during plasma disruption have been calculated. • Effective electrical parameters can be derived from the eddy current characters. • The method for eddy current and effective electrical parameters is suit for the complex shell with arbitrary shape. - Abstract: The electrical parameters of CFETR (China Fusion Engineering Test Reactor) vacuum vessel are very important to the design of control system and power supply system. Effective electrical parameters are relevant to the dynamic of eddy current. For complex structure, the distribution of eddy current can’t be obtained by analytical form. A method is presented to solve the eddy current of the vacuum vessel in this paper. The effective electrical parameters can be got from the eddy current distribution and variation. The time constant of the CFETR vacuum vessel is derived from the decay characteristics of the eddy current. And the effective resistance and inductance can be derived from the viewpoint of energy for a certain distribution of eddy current.

TORE SUPRA vacuum vessel and shield manufacturing

International Nuclear Information System (INIS)

Blateyron, J.; Lepez, R.

1984-01-01

TORE SUPRA vacuum vessel and vacuum chamber shield manufacturing in progress at Jeumont-Schneider consists of three main phases: - Detail engineering and manufacturing fixture construction; - Prototype section manufacturing and process preparation; - Construction of the 6 production modules. The welding techniques adopted, call for three special automatic processes: TIG, MIG and PLASMA welding which guarantee mechanical strength, vacuum tightness and absence of distortion. Production of the modules began July 1984. (author)

Device of supporting a vacuum plasma vessel

International Nuclear Information System (INIS)

Kanoi, Minoru; Hori, Yasuro.

1980-01-01

Purpose: To improve the earthquake-resistance of a vacuum plasma vessel by equalizing the natural vibrations of a vibrating system formed by supporting mechanisms of the respective sectors of the vessel. Constitution: The vacuum plasma vessel is constructed of bellows interposed among a plurality of thick sector-like rings and the rings, which are respectively supported by supporting mechanisms. Thus, the vibrating systems are divided into the rings interposed with the bellows, arms as the supporting mechanisms, and posts. The natural vibrations of these vibrating systems are equalized to each other by suitably adjusting the configurations and the sized of the arms and the posts or the weight or the like of the rings. Therefore, the respective rings become vibrated at the natural vibrations equal to each other so as to largely reduce the stresses produced at both ends of the bellows. Accordingly, it can remarkably improve the earthquake-resistance of the entire plasma vessel. (Sekiya, K.)

Initial conditioning of the TFTR vacuum vessel

International Nuclear Information System (INIS)

Dylla, H.F.; Blanchard, W.R.; Krawchuk, R.B.; Hawryluk, R.J.; Owens, D.K.

1984-01-01

We report on the initial conditioning of the Tokamak Fusion Test Reactor (TFTR) vacuum vessel prior to the initiation of first plasma discharges, and during subsequent operation with high power ohmically-heated plasmas. Following evacuation of the 86 m 3 vessel with the 10 4 1/s high vacuum pumping system, the vessel was conditioned by a 15 A dc glow discharge in H 2 at a pressure of 5 mTorr. Rapid-pulse discharge cleaning was used subsequently to preferentially condition the graphite plasma limiters. The effectiveness of the discharge cleaning was monitored by measuring the exhaust rates of the primary discharge products (CO/C 2 H 4 , CH 4 , and H 2 O). After 175 hours of glow discharge treatment, the equivalent of 50 monolayers of C and O was removed from the vessel, and the partial pressures of impurity gases were reduced to the range of 10 -9 -10 -10 Torr

Expanding plasma jet in a vacuum vessel

International Nuclear Information System (INIS)

Chutov, Yu.I.; Kravchenko, A.Yu.; Yakovetskij, V.S.

1998-01-01

The paper deals with numerical calculations of parameters of a supersonic quasi-neutral argon plasma jet expanding into a cylindrical vacuum vessel and interacting with its inner surface. A modified method of large particles was used, the complex set of hydrodynamic equations being broken into simpler components, each of which describes a separate physical process. Spatial distributions of the main parameters of the argon plasma jet were simulated at various times after the jet entering the vacuum vessel, the parameters being the jet velocity field, the full plasma pressure, the electron temperature, the temperature of heavy particles, and the degree of ionization. The results show a significant effect of plasma jet interaction on the plasma parameters. The jet interaction with the vessel walls may result e.g. in excitation of shock waves and rotational plasma motions. (J.U.)

NCSX Vacuum Vessel Fabrication

International Nuclear Information System (INIS)

Viola ME; Brown T; Heitzenroeder P; Malinowski F; Reiersen W; Sutton L; Goranson P; Nelson B; Cole M; Manuel M; McCorkle D.

2005-01-01

The National Compact Stellarator Experiment (NCSX) is being constructed at the Princeton Plasma Physics Laboratory (PPPL) in conjunction with the Oak Ridge National Laboratory (ORNL). The goal of this experiment is to develop a device which has the steady state properties of a traditional stellarator along with the high performance characteristics of a tokamak. A key element of this device is its highly shaped Inconel 625 vacuum vessel. This paper describes the manufacturing of the vessel. The vessel is being fabricated by Major Tool and Machine, Inc. (MTM) in three identical 120 o vessel segments, corresponding to the three NCSX field periods, in order to accommodate assembly of the device. The port extensions are welded on, leak checked, cut off within 1-inch of the vessel surface at MTM and then reattached at PPPL, to accommodate assembly of the close-fitting modular coils that surround the vessel. The 120 o vessel segments are formed by welding two 60 o segments together. Each 60 o segment is fabricated by welding ten press-formed panels together over a collapsible welding fixture which is needed to precisely position the panels. The vessel is joined at assembly by welding via custom machined 8-inch (20.3 cm) wide spacer ''spool pieces''. The vessel must have a total leak rate less than 5 X 10 -6 t-l/s, magnetic permeability less than 1.02(micro), and its contours must be within 0.188-inch (4.76 mm). It is scheduled for completion in January 2006

Progress and Achievements on the R&D Activities for ITER Vacuum Vessel

Energy Technology Data Exchange (ETDEWEB)

Nakahira, M. [Japan Atomic Energy Research Institute (JAERI); Koizumi, K. [Japan Atomic Energy Research Institute (JAERI); Takahashi, H. [Japan Atomic Energy Research Institute (JAERI); Onozuka, M. [ITER Joint Central Team, Garching, Germany; Ioki, K. [ITER Joint Central Team, Garching, Germany; Kuzumin, E. [D.V. Efremov Scientific Research Institute, St. Petersburg, Russia; Krylov, V. [D.V. Efremov Scientific Research Institute, St. Petersburg, Russia; Maslakowski, J. [Oak Ridge National Laboratory (ORNL); Nelson, Brad E [ORNL; Jones, L. [Max-Planck Institute, Garching, Germany; Danner, W. [Max-Planck Institute, Garching, Germany; Maisonnier, D. [Max-Planck Institute, Garching, Germany

2001-01-01

The ITER vacuum vessel (VV) is designed to be large double-walled structure with a D-shaped crosssection. The achievable fabrication tolerance of this structure was unknown due to the size and complexity of shape. The Full-scale Sector Model of ITER Vacuum Vessel, which was 15m in height, was fabricated and tested to obtain the fabrication and assembly tolerances. The model was fabricated within the target tolerance of 5mm and welding deformation during assembly operation was obtained. The port structure was also connected using remotized welding tools to demonstrate the basic maintenance activity. In parallel, the tests of advanced welding, cutting and inspection system were performed to improve the efficiency of fabrication and maintenance of the Vacuum Vessel. These activities show the feasibility of ITER Vacuum Vessel as feasible in a realistic way. This paper describes the major progress, achievement and latest status of the R&D activities on the ITER vacuum vessel.

Depressurization as a means of leak checking large vacuum vessels

International Nuclear Information System (INIS)

Callis, R.W.; Langhorn, A.; Petersen, P.I.; Ward, C.; Wesley, J.

1985-01-01

A common problem associated with large vacuum vessels used in magnetic confinement fusion experiments is that leak checking is hampered by the inaccessibility to most of the vacuum vessel surface. This inaccessibility is caused by the close proximity of magnetic coils, diagnostics and, for those vessels that are baked, the need to completely surround the vessel with a thermal insulation blanket. These obstructions reduce the effectiveness of the standard leak checking method of using a mass spectrometer and spraying a search gas such as helium on the vessel exterior. Even when the presence of helium is detected, its entry point into the vessel cannot always be pinpointed. This paper will describe a method of overcoming this problem. By slightly depressurizing the vessel, an influx of helium through the leak is created. The leak site can then be identified by personnel within the vessel using standard sniffing procedures. There are two conditions which make this method of leak checking practical. First, the vessel need only be depressurized 2 psi, thus allowing personnel inside to perform the sniffing operation. Second, the sniffing probe used (Leybold--Heraus ''Quick Test'') could detect a change in helium concentration as small as 100 ppb, which allows for faster scanning of the vessel inferior. Use of this technique to find an elusive 10 -3 Torrxl/s leak in the Doublet III tokamak vacuum vessel will be presented

Neutronics studies for the design of the European DEMO vacuum vessel

Energy Technology Data Exchange (ETDEWEB)

Flammini, Davide, E-mail: davide.flammini@enea.it [ENEA, Fusion Technical Unit, Nuclear Technologies Laboratory, Via Enrico Fermi 45, 00044 Frascati, Rome (Italy); Villari, Rosaria; Moro, Fabio; Pizzuto, Aldo [ENEA, Fusion Technical Unit, Nuclear Technologies Laboratory, Via Enrico Fermi 45, 00044 Frascati, Rome (Italy); Bachmann, Christian [EUROfusion Consortium, Boltzmannstr. 2, 85748 Garching (Germany)

2016-11-01

Highlights: • MCNP calculation of nuclear heating, damage, helium production and neutron flux in DEMO HCLL and HCPB vacuum vessel at the inboard equatorial plane. • Study of impact of the poloidal gap between blanket modules, for several gap width, on vacuum vessel nuclear quantities. • Effect of the gap on nuclear heating result to be moderate, however high values of nuclear heating are found, even far from the gap with HCLL blanket. • Radiation damage limit of 2.75 DPA is met with a 1 cm wide gap. Helium production results very sensitive to the gap width. • Comparison between HCLL and HCPB blankets is shown for nuclear heating and neutron flux in the vacuum vessel. - Abstract: The DEMO vacuum vessel, a massive water cooled double-walled steel vessel, is located behind breeding blankets and manifolds and it will be subjected to an intense neutron and photon irradiation. Therefore, a proper evaluation of the vessel nuclear heat loads is required to assure adequate cooling and, given the significant lifetime neutron fluence of DEMO, the radiation damage limit of the vessel needs to be carefully controlled. In the present work nuclear heating, radiation damage (DPA), helium production, neutron and photon fluxes have been calculated on the vacuum vessel at the inboard by means of MCNP5 using a 3D Helium Cooled Lithium Lead (HCLL) DEMO model with 1572 MW of fusion power. In particular, the effect of the poloidal gap between the breeding-blanket segments on vacuum vessel nuclear loads has been estimated varying the gap width from 0 to 5 cm. High values of the nuclear heating (≈1 W/cm{sup 3}), which might cause intense thermal stresses, were obtained in inboard equatorial zone. The effect of the poloidal gap on the nuclear heating resulted to be moderate (within 30%). The radiation damage limit of 2.75 DPA on the vessel is almost met with 1 cm of poloidal gap over DEMO lifetime. A comparison with Helium Cooled Pebble Bed blanket is also provided.

Welding distortion control in double walled KSTAR vacuum vessel fabrication

International Nuclear Information System (INIS)

Oh, D. W.; Lee, G. T.; Kim, H. K.; Yang, H. L.; Bak, J. S.

2004-01-01

The KSTAR(Korea Superconducting Tokamak Advanced Research) vacuum vessel is designed to be a double walled structure made of 12mm thick 316LN stainless steel with a D shaped cross-section about 4 m height. Vacuum vessel was pre-fabricated in two parts, 180 degree and 157.5 degree sectors in toroidal direction to meet the transportation purpose. These two parts have to be welded on site with ±2mm allowable fabrication tolerances. 1/3 scaled mock-up model was used to estimate the welding distortion and to ensure the weld quality of vacuum vessel. Gas Tungsten Arc Welding(GTAW), which has been approved by procedure qualification test, was used during mock-up test and vacuum vessel site fabrication. Welding distortion could be managed by allowing for distortion in opposite direction, by applying high restraint using lots of strong backs, by controlling the welding heat input with symmetrical welding sequence. The integrity of the site welding joint was assured by radiographic test, ultrasonic test and leak test with helium detecting method

Preliminary structural assessment of DEMO vacuum vessel against a vertical displacement event

International Nuclear Information System (INIS)

Mozzillo, Rocco; Tarallo, Andrea; Marzullo, Domenico; Bachmann, Christian; Di Gironimo, Giuseppe; Mazzone, Giuseppe

2016-01-01

Highlights: • The paper focuses on a preliminary structural analysis of the current concept design of DEMO vacuum vessel. • The Vacuum Vessel was checked against the VDE in combinations with the weight force of all components that the vessel shall bear. • Different configurations for the vacuum vessel supports are considered, showing that the best solution is VV supported at the lower port. • The analyses evaluated the “P damage” according to RCC-MRx code. - Abstract: This paper focuses on a preliminary structural analysis of the current concept design of DEMO vacuum vessel (VV). The VV structure is checked against a vertical load due to a Vertical Displacement Event in combination with the weight force of all components that the main vessel shall bear. Different configurations for the supports are considered. Results show that the greatest safety margins are reached when the tokamak is supported through the lower ports rather than the equatorial ports, though all analyzed configurations are compliant with RCC-MRx design rules.

Preliminary structural assessment of DEMO vacuum vessel against a vertical displacement event

Energy Technology Data Exchange (ETDEWEB)

Mozzillo, Rocco, E-mail: rocco.mozzillo@unina.it [CREATE, University of Naples Federico II, DII, P.le Tecchio 80, 80125, Naples (Italy); Tarallo, Andrea; Marzullo, Domenico [CREATE, University of Naples Federico II, DII, P.le Tecchio 80, 80125, Naples (Italy); Bachmann, Christian [EUROfusion PMU, Boltzmannstraße 2, 85748 Garching (Germany); Di Gironimo, Giuseppe [CREATE, University of Naples Federico II, DII, P.le Tecchio 80, 80125, Naples (Italy); Mazzone, Giuseppe [Unità Tecnica Fusione - ENEA C.R. Frascati, Via E. Fermi 45, 00044 Frascati (Italy)

2016-11-15

Highlights: • The paper focuses on a preliminary structural analysis of the current concept design of DEMO vacuum vessel. • The Vacuum Vessel was checked against the VDE in combinations with the weight force of all components that the vessel shall bear. • Different configurations for the vacuum vessel supports are considered, showing that the best solution is VV supported at the lower port. • The analyses evaluated the “P damage” according to RCC-MRx code. - Abstract: This paper focuses on a preliminary structural analysis of the current concept design of DEMO vacuum vessel (VV). The VV structure is checked against a vertical load due to a Vertical Displacement Event in combination with the weight force of all components that the main vessel shall bear. Different configurations for the supports are considered. Results show that the greatest safety margins are reached when the tokamak is supported through the lower ports rather than the equatorial ports, though all analyzed configurations are compliant with RCC-MRx design rules.

ATLAS Supplier Award for the ECT Vacuum Vessels

CERN Multimedia

Jenni, P

On 12 February the Netherlands firm Schelde Exotech was awarded the ATLAS Supplier Award for the construction of the two vacuum vessels for the ATLAS End- Cap Toroid (ECT) magnets. ATLAS Supplier Award ceremonies have now become something of a tradition. For the third consecutive year, ATLAS has given best supplier awards for the most exceptional contributors to the construction of the detector. The Netherlands firm Schelde Exotech has just received the award for the construction of the two vacuum vessels for the ECTs. With a diameter of 11 metres and a volume of 550 cubic metres, the ECT vacuum vessels are obviously impressive in scale. They consist of large aluminium plates and a stainless steel central bore tube. In order to obtain the required undulations, the firm had to develop a special assembly and welding technique. Despite the chambers' imposing size, a very high degree of precision has been achieved in their geometry. Moreover, the chambers, which were delivered in July 2002 to CERN, were built i...

New baking system for the RFX vacuum vessel

Energy Technology Data Exchange (ETDEWEB)

Collarin, P.; Luchetta, A.; Sonato, P.; Toigo, V.; Zaccaria, P.; Zollino, G. [Universita di Padova (Italy)

1996-12-31

A heating system based on eddy currents has been developed for the vacuum vessel of the RFX Reversed Field Pinch device. After a testing phase, carried out at low power, the final power supply system has been designed and installed. It has been used during last year to bake out the vessel and the graphite first wall up to 320{degree}C. Recently the heating system has been completed with a control system that allows for baking sessions with an automatic control of the vacuum vessel temperature and for pulse sessions with a heated first wall. After the description of the preliminary analyses and tests, and of the main characteristics of the power supply and control systems, the experimental results of the baking sessions performed during last year are presented. 6 refs., 7 figs.

New baking system for the RFX vacuum vessel

International Nuclear Information System (INIS)

Collarin, P.; Luchetta, A.; Sonato, P.; Toigo, V.; Zaccaria, P.; Zollino, G.

1996-01-01

A heating system based on eddy currents has been developed for the vacuum vessel of the RFX Reversed Field Pinch device. After a testing phase, carried out at low power, the final power supply system has been designed and installed. It has been used during last year to bake out the vessel and the graphite first wall up to 320 degree C. Recently the heating system has been completed with a control system that allows for baking sessions with an automatic control of the vacuum vessel temperature and for pulse sessions with a heated first wall. After the description of the preliminary analyses and tests, and of the main characteristics of the power supply and control systems, the experimental results of the baking sessions performed during last year are presented. 6 refs., 7 figs

Design and manufacturing of vacuum vessel of TPE-RX

Energy Technology Data Exchange (ETDEWEB)

Sago, H.; Kaguchi, H.; Orita, J.; Ishigami, Y. [Mitsubishi Heavy Industries Ltd., Kobe (Japan); Urata, K. [Mitsubishi Heavy Industries Ltd. (Japan). Nuclear Energy Systems Engineering Center; Hasegawa, M. [Mitsubishi Electric Co. (Japan). Nuclear Fusion Development; Yagi, Y.; Hirano, Y.; Shimada, T.; Sekine, S.; Sakakita, H. [Electrotechnical Lab. (Japan)

1998-07-01

Construction of a new, large reversed field pinch (RFP) machine called TPE-RX was complete at the end of 1997 as a successor of the previous TPE-1RM20 machine at the Electrotechnical Laboratory (ETL). RFP configuration has been successfully obtained in March 1998. This paper introduces structural design and manufacturing of the vacuum vessel of TPE-RX. The support positions were decided by structural analyses. The structural integrity of the vacuum vessel was evaluated by inelastic analyses. (author)

Design and manufacturing of vacuum vessel of TPE-RX

International Nuclear Information System (INIS)

Sago, H.; Kaguchi, H.; Orita, J.; Ishigami, Y.; Urata, K.

1998-01-01

Construction of a new, large reversed field pinch (RFP) machine called TPE-RX was complete at the end of 1997 as a successor of the previous TPE-1RM20 machine at the Electrotechnical Laboratory (ETL). RFP configuration has been successfully obtained in March 1998. This paper introduces structural design and manufacturing of the vacuum vessel of TPE-RX. The support positions were decided by structural analyses. The structural integrity of the vacuum vessel was evaluated by inelastic analyses. (author)

Progress of ITER vacuum vessel

Energy Technology Data Exchange (ETDEWEB)

Ioki, K., E-mail: Kimihiro.Ioki@iter.org [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Bayon, A. [F4E, c/ Josep Pla, No. 2, Torres Diagonal Litoral, Edificio B3, E-08019 Barcelona (Spain); Choi, C.H.; Daly, E.; Dani, S.; Davis, J.; Giraud, B.; Gribov, Y.; Hamlyn-Harris, C.; Jun, C.; Levesy, B. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Kim, B.C. [NFRI, 52 Yeoeundong Yuseonggu, Daejeon 305-333 (Korea, Republic of); Kuzmin, E. [NTC “Sintez”, Efremov Inst., 189631 Metallostroy, St. Petersburg (Russian Federation); Le Barbier, R.; Martinez, J.-M. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Pathak, H. [ITER-India, A-29, GIDC Electronic Estate, Sector 25, Gandhinagar 382025 (India); Preble, J. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Sa, J.W. [NFRI, 52 Yeoeundong Yuseonggu, Daejeon 305-333 (Korea, Republic of); Terasawa, A.; Utin, Yu. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); and others

2013-10-15

Highlights: ► This covers the overall status and progress of the ITER vacuum vessel activities. ► It includes design, R and D, manufacturing and approval process of the regulators. ► The baseline design was completed and now manufacturing designs are on-going. ► R and D includes ISI, dynamic test of keys and lip-seal welding/cutting technology. ► The VV suppliers produced full-scale mock-ups and started VV manufacturing. -- Abstract: Design modifications were implemented in the vacuum vessel (VV) baseline design in 2011–2012 for finalization. The modifications are mostly due to interface components, such as support rails and feedthroughs for the in-vessel coils (IVC). Manufacturing designs are being developed at the domestic agencies (DAs) based on the baseline design. The VV support design was also finalized and tests on scale mock-ups are under preparation. Design of the in-wall shielding (IWS) has progressed, considering the assembly methods and the required tolerances. Further modifications are required to be consistent with the DAs’ manufacturing designs. Dynamic tests on the inter-modular and stub keys to support the blanket modules are being performed to measure the dynamic amplification factor (DAF). An in-service inspection (ISI) plan has been developed and R and D was launched for ISI. Conceptual design of the VV instrumentation has been developed. The VV baseline design was approved by the agreed notified body (ANB) in accordance with the French Nuclear Pressure Equipment Order procedure.

Progress of ITER vacuum vessel

International Nuclear Information System (INIS)

Ioki, K.; Bayon, A.; Choi, C.H.; Daly, E.; Dani, S.; Davis, J.; Giraud, B.; Gribov, Y.; Hamlyn-Harris, C.; Jun, C.; Levesy, B.; Kim, B.C.; Kuzmin, E.; Le Barbier, R.; Martinez, J.-M.; Pathak, H.; Preble, J.; Sa, J.W.; Terasawa, A.; Utin, Yu.

2013-01-01

Highlights: ► This covers the overall status and progress of the ITER vacuum vessel activities. ► It includes design, R and D, manufacturing and approval process of the regulators. ► The baseline design was completed and now manufacturing designs are on-going. ► R and D includes ISI, dynamic test of keys and lip-seal welding/cutting technology. ► The VV suppliers produced full-scale mock-ups and started VV manufacturing. -- Abstract: Design modifications were implemented in the vacuum vessel (VV) baseline design in 2011–2012 for finalization. The modifications are mostly due to interface components, such as support rails and feedthroughs for the in-vessel coils (IVC). Manufacturing designs are being developed at the domestic agencies (DAs) based on the baseline design. The VV support design was also finalized and tests on scale mock-ups are under preparation. Design of the in-wall shielding (IWS) has progressed, considering the assembly methods and the required tolerances. Further modifications are required to be consistent with the DAs’ manufacturing designs. Dynamic tests on the inter-modular and stub keys to support the blanket modules are being performed to measure the dynamic amplification factor (DAF). An in-service inspection (ISI) plan has been developed and R and D was launched for ISI. Conceptual design of the VV instrumentation has been developed. The VV baseline design was approved by the agreed notified body (ANB) in accordance with the French Nuclear Pressure Equipment Order procedure

Electromagnetic forces on a metallic Tokamak vacuum vessel following a disruptive instability

International Nuclear Information System (INIS)

Eckhartt, D.

1979-04-01

During a 'hard' disruptive instability of a Tokamak plasma the current-carrying plasma is lost within a very short time, typically few milliseconds. If the plasma is contained in a metallic vacuum vessel, electric currents are set up in the vessel following the disappearance of the plasma current. These vessel currents together with the magnetic fields intersecting the vessel generate electromagnetic forces which appear as mechanical loads on the vessel. In the following note it is assumed that the vacuum vessel is surrounded by an 'outer equivalent' or 'flux-conserving' shell having a characteristic time of magnetic field penetration which is long compared to the time of existence of the vessel currents. This property defines the distribution of vessel current densities (and hence the load distribution) without referring to the exact mechanism or time sequence of events by which the plasma current is lost. Numerical examples of the electromagnetic force distribution from this model refer to parameters of the JET-device with the simplifying assumption of circular cross-sections for plasma current, vacuum vessel, and outer equivalent shell. (orig.)

Structural design and manufacturing of TPE-RX vacuum vessel

Energy Technology Data Exchange (ETDEWEB)

Sago, H.; Orita, J.; Kaguchi, H.; Ishigami, Y. [Mitsubishi Heavy Ind. Ltd., Kobe (Japan); Urata, K.; Kudough, F. [Mitsubishi Heavy Industries, Ltd., Tokyo (Japan); Hasegawa, M.; Oyabu, I. [Mitsubishi Electric Co., Tokyo (Japan); Yagi, Y.; Sekine, S.; Shimada, T.; Hirano, Y.; Sakakita, H.; Koguchi, H. [Electrotechnical Laboratory, Tsukuba (Japan)

1999-10-01

TPE-RX is a newly constructed, large-sized reversed field pinch (RFP) machine installed at the Electrotechnical Laboratory of the Ministry of International Trade and Industry in Japan. This is the third largest RFP in the world. Major and minor radii of the plasma are 1.72 and 0.45 m, respectively. TPE-RX aims to optimize plasma confinement up to 1 MA. RFP plasma configuration was successfully obtained in March 1998. This paper reports the structural design and manufacturing of the vacuum vessel of TPE-RX. The supporting system on the bellows sections of the vessel was designed based on a detailed finite element method. The integrity of the vacuum vessel against a plasma disruption has been confirmed using dynamic inelastic analyses. (orig.)

Structural design and manufacturing of TPE-RX vacuum vessel

International Nuclear Information System (INIS)

Sago, H.; Orita, J.; Kaguchi, H.; Ishigami, Y.; Urata, K.; Kudough, F.; Hasegawa, M.; Oyabu, I.; Yagi, Y.; Sekine, S.; Shimada, T.; Hirano, Y.; Sakakita, H.; Koguchi, H.

1999-01-01

TPE-RX is a newly constructed, large-sized reversed field pinch (RFP) machine installed at the Electrotechnical Laboratory of the Ministry of International Trade and Industry in Japan. This is the third largest RFP in the world. Major and minor radii of the plasma are 1.72 and 0.45 m, respectively. TPE-RX aims to optimize plasma confinement up to 1 MA. RFP plasma configuration was successfully obtained in March 1998. This paper reports the structural design and manufacturing of the vacuum vessel of TPE-RX. The supporting system on the bellows sections of the vessel was designed based on a detailed finite element method. The integrity of the vacuum vessel against a plasma disruption has been confirmed using dynamic inelastic analyses. (orig.)

Analysis of toroidal vacuum vessels for use in demonstration sized tokamak reactors

International Nuclear Information System (INIS)

Culbert, M.E.

1978-07-01

The vacuum vessel component of the tokamak fusion reactor is the subject of this study. The main objective of this paper was to provide guidance for the structural design of a thin wall externally pressurized toroidal vacuum vessel. The analyses are based on the available state-of-the-art analytical methods. The shortcomings of these analytical methods necessitated approximations and assumptions to be made throughout the study. A principal result of the study has been the identification of a viable vacuum vessel design for the Demonstration Tokamak Hybrid Reactor (DTHR) and The Next Step (TNS) Reactor

The baking analysis for vacuum vessel and plasma facing components of the KSTAR tokamak

International Nuclear Information System (INIS)

Lee, K. H.; Woo, H. K.; Im, K. H.; Cho, S. Y.; Kim, J. B.

2000-01-01

The base pressure of vacuum vessel of the KSTAR (Korea Superconducting Tokamak Advanced Research) Tokamak is to be a ultra high vacuum, 10 -6 ∼10 -7 Pa, to produce clean plasma with low impurity containments. For this purpose, the KSTAR vacuum vessel and plasma facing components need to be baked up to at least 250 .deg. C, 350 .deg. C respectively, within 24 hours by hot nitrogen gas from a separate baking/cooling line system to remove impurities from the plasma-material interaction surfaces before plasma operation. Here by applying the implicit numerical method to the heat balance equations of the system, overall temperature distributions of the KSTAR vacuum vessel and plasma facing components are obtained during the whole baking process. The model for 2-dimensional baking analysis are segmented into 9 imaginary sectors corresponding to each plasma facing component and has up-down symmetry. Under the resulting combined loads including dead weight, baking gas pressure, vacuum pressure and thermal loads, thermal stresses in the vacuum vessel during bakeout are calculated by using the ANSYS code. It is found that the vacuum vessel and its supports are structurally rigid based on the thermal stress analyses

The baking analysis for vacuum vessel and plasma facing components of the KSTAR tokamak

Energy Technology Data Exchange (ETDEWEB)

Lee, K. H.; Woo, H. K. [Chungnam National Univ., Taejon (Korea, Republic of); Im, K. H.; Cho, S. Y. [korea Basic Science Institute, Taejon (Korea, Republic of); Kim, J. B. [Hyundai Heavy Industries Co., Ltd., Ulsan (Korea, Republic of)

2000-07-01

The base pressure of vacuum vessel of the KSTAR (Korea Superconducting Tokamak Advanced Research) Tokamak is to be a ultra high vacuum, 10{sup -6}{approx}10{sup -7}Pa, to produce clean plasma with low impurity containments. For this purpose, the KSTAR vacuum vessel and plasma facing components need to be baked up to at least 250 .deg. C, 350 .deg. C respectively, within 24 hours by hot nitrogen gas from a separate baking/cooling line system to remove impurities from the plasma-material interaction surfaces before plasma operation. Here by applying the implicit numerical method to the heat balance equations of the system, overall temperature distributions of the KSTAR vacuum vessel and plasma facing components are obtained during the whole baking process. The model for 2-dimensional baking analysis are segmented into 9 imaginary sectors corresponding to each plasma facing component and has up-down symmetry. Under the resulting combined loads including dead weight, baking gas pressure, vacuum pressure and thermal loads, thermal stresses in the vacuum vessel during bakeout are calculated by using the ANSYS code. It is found that the vacuum vessel and its supports are structurally rigid based on the thermal stress analyses.

Vacuum vessel for plasma devices

International Nuclear Information System (INIS)

Yamada, Masao; Taguchi, Masami.

1975-01-01

Object: To permit effective utility of the space in the inner and outer sides of the container wall and also permit repeated assembly for use. Structure: Vacuum vessel wall sections are sealed together by means of welding bellows, and also flange portions formed at the end of the wall sections are coupled together by bolts and are sealed together with a seal ring and a seal cap secured by welding. (Nakamura, S.)

Structural analysis of the ITER vacuum vessel from disruption loading with halo asymmetry

International Nuclear Information System (INIS)

Riemer, B.W.; Sayer, R.O.

1996-01-01

Static structural analyses of the ITER vacuum vessel were performed with toroidally asymmetric disruption loads. Asymmetric halo current conditions were assumed to modify symmetric disruption loads which resulted in net lateral loading on the vacuum vessel torus. Structural analyses with the asymmetric loading indicated significantly higher vessel stress and blanket support forces than with symmetric disruption loads. A recent change in the vessel support design which provided toroidal constraints at each mid port was found to be effective in reducing torus lateral movement and vessel stress

The baking analysis for vacuum vessel and plasma facing components of the KSTAR tokamak

Energy Technology Data Exchange (ETDEWEB)

Lee, K.H. [Chungnam National University Graduate School, Taejeon (Korea); Im, K.H.; Cho, S.Y. [Korea Basic Science Institute, Taejeon (Korea); Kim, J.B. [Hyundai Heavy Industries Co., Ltd. (Korea); Woo, H.K. [Chungnam National University, Taejeon (Korea)

2000-11-01

The base pressure of vacuum vessel of the KSTAR (Korea Superconducting Tokamak Advanced Research) Tokamak is to be a ultra high vacuum, 10{sup -6} {approx} 10{sup -7} Pa, to produce clean plasma with low impurity containments. for this purpose, the KSTAR vacuum vessel and plasma facing components need to be baked up to at least 250 deg.C, 350 deg.C respectively, within 24 hours by hot nitrogen gas from a separate baking/cooling line system to remove impurities from the plasma-material interaction surfaces before plasma operation. Here by applying the implicit numerical method to the heat balance equations of the system, overall temperature distributions of the KSTAR vacuum vessel and plasma facing components are obtained during the whole baking process. The model for 2-dimensional baking analysis are segmented into 9 imaginary sectors corresponding to each plasma facing component and has up-down symmetry. Under the resulting combined loads including dead weight, baking gas pressure, vacuum pressure and thermal loads, thermal stresses in the vacuum vessel during bakeout are calculated by using the ANSYS code. It is found that the vacuum vessel and its supports are structurally rigid based on the thermal stress analyses. (author). 9 refs., 11 figs., 1 tab.

Status of the ITER vacuum vessel construction

Energy Technology Data Exchange (ETDEWEB)

Choi, C.H.; Sborchia, C.; Ioki, K.; Giraud, B.; Utin, Yu.; Sa, J.W. [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul Lez Durance (France); Wang, X., E-mail: xiaoyuwww@gmail.com [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul Lez Durance (France); Teissier, P.; Martinez, J.M.; Le Barbier, R.; Jun, C.; Dani, S.; Barabash, V.; Vertongen, P.; Alekseev, A. [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul Lez Durance (France); Jucker, P.; Bayon, A. [F4E, c/ Josep Pla, n. 2, Torres Diagonal Litoral, Edificio B3, E-08019 Barcelona (Spain); Pathak, H.; Raval, J. [ITER-India, IPR, A-29, Electronics Estate, GIDC, Sector-25, Gandhinagar 382025 (India); Ahn, H.J. [ITER Korea, National Fusion Research Institute, Daejeon (Korea, Republic of); and others

2014-10-15

Highlights: • Final design of the ITER vacuum vessel (VV). • Procurement of the ITER VV. • Manufacturing results of real scale mock-ups. • Manufacturing status of the VV in domestic agencies. - Abstract: The ITER vacuum vessel (VV) is under manufacturing by four domestic agencies after completion of engineering designs that have been approved by the Agreed Notified Body (ANB). Manufacturing designs of the VV have been being completed, component by component, by accommodating requirements of the RCC-MR 2007 edition. Manufacturing of the VV first sector has been started in February 2012 in Korea and in-wall shielding in May 2013 in India. EU will start manufacturing of its first sector from September 2013 and Russia the upper port by the end of 2013. All DAs have manufactured several mock-ups including real-size ones to justify/qualify and establish manufacturing techniques and procedures.

2XIIB vacuum vessel: a unique design

International Nuclear Information System (INIS)

Hibbs, S.M.; Calderon, M.O.

1975-01-01

The 2XIIB mirror confinement experiment makes unique demands on its vacuum system. The confinement coil set encloses a cavity whose surface is comprised of both simple and compound curves. Within this cavity and at the core of the machine is the operating vacuum which is on the order of 10 -9 Torr. The vacuum container fits inside the cavity, presenting an inside surface suitable for titanium getter pumping and a means of removing the heat load imposed by incandescent sublimator wires. In addition, the cavity is constructed of nonmagnetic and nonconducting materials (nonmetals) to avoid distortion of the pulsed confinement field. It is also isolated from mechanical shocks induced in the machine's main structure when the coils are pulsed. This paper describes the design, construction, and operation of the 2XIIB high-vacuum vessel that has been performing successfully since early 1974

Advanced toroidal facility vaccuum vessel stress analyses

International Nuclear Information System (INIS)

Hammonds, C.J.; Mayhall, J.A.

1987-01-01

The complex geometry of the Advance Toroidal Facility (ATF) vacuum vessel required special analysis techniques in investigating the structural behavior of the design. The response of a large-scale finite element model was found for transportation and operational loading. Several computer codes and systems, including the National Magnetic Fusion Energy Computer Center Cray machines, were implemented in accomplishing these analyses. The work combined complex methods that taxed the limits of both the codes and the computer systems involved. Using MSC/NASTRAN cyclic-symmetry solutions permitted using only 1/12 of the vessel geometry to mathematically analyze the entire vessel. This allowed the greater detail and accuracy demanded by the complex geometry of the vessel. Critical buckling-pressure analyses were performed with the same model. The development, results, and problems encountered in performing these analyses are described. 5 refs., 3 figs

Evaluation of structural reliability for vacuum vessel under external pressure and electromagnetic force

International Nuclear Information System (INIS)

Minato, Akio

1983-08-01

Static and dynamic structural analyses of the vacuum vessel for a Swimming Pool Type Tokamak Reactor (SPTR) have been conducted under the external pressure (hydraulic and atmospheric pressure) during normal operation or the electromagnetic force due to plasma disruption. The reactor structural design is based on the concept that the adjacent modules of the vacuum vessel are not connected mechanically with bolts in the torus inboard region each other, so as to save the required space for inserting the remote handling machine for tightenning and untightenning bolts in the region and to simplify the repair and maintenance of the reactor. The structural analyses of the vacuum vessel have been carried out under the external pressure and the electromagnetic force and the structural reliability against the static and dynamic loads is estimated. The several configurations of the lip seal between the modules, which is required to make a plasma vacuum boundary, have been proposed and the structural strength under the forced displacements due to the deformation of the vacuum vessel is also estimated. (author)

Eddy currents in a nonperiodic vacuum vessel induced by axisymmetric plasma motion

International Nuclear Information System (INIS)

DeLucia, J.

1985-12-01

A method is described for calculating the two-dimensional trajectory of a vertically or horizontally unstable axisymmetric tokamak plasma in the presence of a resistive vacuum vessel. The vessel is not assumed to have toroidal symmetry. The plasma is represented by a current-filament loop that is free to move vertically and to change its major radius. Its position is evolved in time self-consistently with the vacuum vessel eddy currents. The plasma current, internal inductance, and poloidal beta can be specified functions of time so that eddy currents resulting from a disruption can be modeled. The vacuum vessel is represented by a set of current-filaments whose positions and orientations are chosen to model the dominant eddy current paths. Although the specific application is to TFTR, the present model is of general applicability. 7 refs., 4 figs., 2 tabs

Design of the Intersector Welding Robot for vacuum vessel assembly and maintenance

International Nuclear Information System (INIS)

Jones, L.; Dagenais, J.-F.; Daenner, W.; Maisonnier, D.

2000-01-01

Next Step Fusion Devices require on-site (field weld) joining of sectors of the thick-walled vacuum vessel for structural and vacuum integrity. EFDA (European Fusion Development Agreement) is supporting an R and D programme to investigate processes for assembly of the vacuum vessel and to carry out cutting, re-welding and inspection for remote sector replacement, forming part of the overall VV/blanket research effort. In order to direct the process end-effectors along the field joint zone, a track-mounted Intersector Welding Robot (IWR) on a mock-up of a region of the vacuum vessel has been designed and is described in this paper. A rail-mounted hexapod type robot offers six axes of motion over a limited work envelope with high payload to robot weight ratio. A solution to the production of reduced pressure local vacuum is the installation of short, lightweight segments bolted to each other and the vessel wall. The various process heads can be mounted using end-effectors of special design. To minimise the supply and interface problems for the IWR prototype, its motion control and electronic systems will be embedded locally. A laser scan with camera forms the on-line seam tracking capability to compensate for rail and seam deviations

The vacuum vessel for the FTU device: design constraints and stress analysis

International Nuclear Information System (INIS)

Andreani, R.; Cecchini, A.; Gasparotto, M.; Lovisetto, L.; Migliori, S.; Pizzuto, A.

1984-01-01

The FTU vacuum vessel must withstand large electromagnetic loads due to the interactions between the eddy currents in the vessel and high magnetic fields of the machine, the atmospheric pressure and the severe thermal loads due to plasma losses and RF power not coupled to the plasma. In order to minimise the stresses on the vacuum chamber, an optimization of the wall thickness has been performed and, in order to assess the feasibility of the vessel, an extensive three dimensional finite element stress analysis has been developed. The main results obtained are illustrated. (author)

Structural analysis of the ITER Vacuum Vessel regarding 2012 ITER Project-Level Loads

Energy Technology Data Exchange (ETDEWEB)

Martinez, J.-M., E-mail: jean-marc.martinez@live.fr [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul lez Durance (France); Jun, C.H.; Portafaix, C.; Choi, C.-H.; Ioki, K.; Sannazzaro, G.; Sborchia, C. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul lez Durance (France); Cambazar, M.; Corti, Ph.; Pinori, K.; Sfarni, S.; Tailhardat, O. [Assystem EOS, 117 rue Jacquard, L' Atrium, 84120 Pertuis (France); Borrelly, S. [Sogeti High Tech, RE2, 180 rue René Descartes, Le Millenium – Bat C, 13857 Aix en Provence (France); Albin, V.; Pelletier, N. [SOM Calcul – Groupe ORTEC, 121 ancien Chemin de Cassis – Immeuble Grand Pré, 13009 Marseille (France)

2014-10-15

Highlights: • ITER Vacuum Vessel is a part of the first barrier to confine the plasma. • ITER Vacuum Vessel as Nuclear Pressure Equipment (NPE) necessitates a third party organization authorized by the French nuclear regulator to assure design, fabrication, conformance testing and quality assurance, i.e. Agreed Notified Body (ANB). • A revision of the ITER Project-Level Load Specification was implemented in April 2012. • ITER Vacuum Vessel Loads (seismic, pressure, thermal and electromagnetic loads) were summarized. • ITER Vacuum Vessel Structural Margins with regards to RCC-MR code were summarized. - Abstract: A revision of the ITER Project-Level Load Specification (to be used for all systems of the ITER machine) was implemented in April 2012. This revision supports ITER's licensing by accommodating requests from the French regulator to maintain consistency with the plasma physics database and our present understanding of plasma transients and electro-magnetic (EM) loads, to investigate the possibility of removing unnecessary conservatism in the load requirements and to review the list and definition of incidental cases. The purpose of this paper is to present the impact of this 2012 revision of the ITER Project-Level Load Specification (LS) on the ITER Vacuum Vessel (VV) loads and the main structural margins required by the applicable French code, RCC-MR.

Integration of cooking and vacuum cooling of carrots in a same vessel

Directory of Open Access Journals (Sweden)

Luiz Gustavo Gonçalves Rodrigues

2012-03-01

Full Text Available Cooked vegetables are commonly used in the preparation of ready-to-eat foods. The integration of cooking and cooling of carrots and vacuum cooling in a single vessel is described in this paper. The combination of different methods of cooking and vacuum cooling was investigated. Integrated processes of cooking and vacuum cooling in a same vessel enabled obtaining cooked and cooled carrots at the final temperature of 10 ºC, which is adequate for preparing ready-to-eat foods safely. When cooking and cooling steps were performed with the samples immersed in boiling water, the effective weight loss was approximately 3.6%. When the cooking step was performed with the samples in boiling water or steamed, and the vacuum cooling was applied after draining the boiling water, water loss ranged between 15 and 20%, which caused changes in the product texture. This problem can be solved with rehydration using a small amount of sterile cold water. The instrumental textural properties of carrots samples rehydrated at both vacuum and atmospheric conditions were very similar. Therefore, the integrated process of cooking and vacuum cooling of carrots in a single vessel is a feasible alternative for processing such kind of foods.

Temperature field and thermal stress analysis of the HT-7U vacuum vessel

International Nuclear Information System (INIS)

Song Yuntao; Yao Damao; Wu Songtao; Weng Peide

2000-01-01

The HT-7U vacuum vessel is an all-metal-welded double-wall interconnected with toroidal and poloidal stiffening ribs. The channels formed between the ribs and walls are filled with boride water as a nuclear shielding. On the vessel surface facing the plasma are installed cable-based Ohmic heaters. Prior to plasma operation the vessel is to be baked out and discharge cleaned at about 250 degree C. During baking out the non-uniformity of temperature distribution on the vacuum vessel will bring about serious thermal stress that can damage the vessel. In order to determine and optimize the design of the HT-7U vacuum vessel, a three-dimensional finite element model was performed to analyse its temperature field and thermal stress. the maximal thermal stress appeared on the round of lower vertical port and maximal deformation located just on the region between the upper vertical port and the horizontal port. The results show that the reinforced structure has a good capability of withstanding the thermal loads

Shielding performance of the NET vacuum vessel

International Nuclear Information System (INIS)

Arkuszewski, J.J.; Jaeger, J.F.

1988-01-01

To corroborate 1-D deterministic shielding calculations on the Next European Torus (NET) vacuum vessel/shield and shielding blanket, 3-D Monte Carlo calculations have been done with the MCNP code. This should provide information on the poloidal and the toroidal variations. Plasma source simulation and the geometrical model are described, as are other assumptions. The calculations are based on the extended plasma power of 714 MW. The results reported here are the heat deposition in various parts of the device, on the one hand, and the neutron and photon currents at the outer boundary of the vacuum vessel, on the other hand. The latter are needed for the detailed design of the super-conducting magnetic coils. A reasonable statistics has been obtained on the outboard side of the torus, though this cannot be said for the inboard side. The inboard is, however, much more toroidally symmetric than the outboard, so that other methods could be applied such as 2-D deterministic calculations, for instance. (author) 4 refs., 44 figs., 42 tabs

Fabrication progress of the ITER vacuum vessel sector in Korea

Energy Technology Data Exchange (ETDEWEB)

Kim, B.C., E-mail: bckim@nfri.re.kr [National Fusion Research Institute, Gwahangno 113, Yuseong-gu, Daejeon (Korea, Republic of); Lee, Y.J.; Hong, K.H.; Sa, J.W.; Kim, H.S.; Park, C.K.; Ahn, H.J.; Bak, J.S.; Jung, K.J. [National Fusion Research Institute, Gwahangno 113, Yuseong-gu, Daejeon (Korea, Republic of); Park, K.H.; Roh, B.R.; Kim, T.S.; Lee, J.S.; Jung, Y.H.; Sung, H.J.; Choi, S.Y.; Kim, H.G.; Kwon, I.K.; Kwon, T.H. [Hyundai Heavy Industries Co. Ltd., Dong-gu, Ulsan (Korea, Republic of)

2013-10-15

Highlights: ► Fabrication of ITER vacuum vessel sector full scale mock-up to develop fabrication procedures. ► The welding and nondestructive examination techniques conform to RCC-MR. ► The preparation of real manufacturing of ITER vacuum vessel sector. -- Abstract: As a participant of ITER project, ITER Korea has to supply two ITER vacuum vessel sectors (Sector no. 6, no. 1) of total nine ITER VV sectors. After the procurement arrangement with ITER Organization, ITER Korea made the contract with Hyundai Heavy Industries (HHI) for fabrication of two sectors. Then the start of the manufacturing design was initiated from January 2010. HHI made three real scale R and D mock-ups to verify the critical fabrication feasibility issues on electron beam welding, 3D forming, welding distortion and achievable tolerances. The documentation according to IO and the French nuclear safety regulation requirement, the qualification of welding and nondestructive examination procedures conform to RCC-MR 2007 were proceed in parallel. The mass production of raw material was done after receiving ANB (agreed notified body) verification of product/parts and shop qualification. The manufacturing drawing, manufacturing and inspection plan of VV sector with supporting fabrication procedures are also verified by ANB, accordingly the first cutting and forming of plates for VV sector fabrication started from February 2012. This paper reports the latest fabrication progress of ITER vacuum vessel Sector no. 6 that will be assembled as the first sector in the ITER pit. The overall fabrication route, R and D mock-up fabrication results with forming and welding distortion analysis, qualification status of welding and nondestructive examination (NDE) are also presented.

Testing program for burning plasma experiment vacuum vessel bolted joint

International Nuclear Information System (INIS)

Hsueh, P.K.; Khan, M.Z.; Swanson, J.; Feng, T.; Dinkevich, S.; Warren, J.

1992-01-01

As presently designed, the Burning Plasma Experiment vacuum vessel will be segmentally fabricated and assembled by bolted joints in the field. Due to geometry constraints, most of the bolted joints have significant eccentricity which causes the joint behavior to be sensitive to joint clamping forces. Experience indicates that as a result of this eccentricity, the joint will tend to open at the side closest to the applied load with the extent of the opening being dependent on the initial preload. In this paper analytical models coupled with a confirmatory testing program are developed to investigate and predict the non-linear behavior of the vacuum vessel bolted joint

MFTF-α+T end cell vacuum vessel and nuclear shield trade studies

International Nuclear Information System (INIS)

Kirchner, J.

1984-01-01

Three separate and distinct vacuum vessel and nuclear shield trade studies were performed in series. The studies are: vacuum topology, nuclear shield location and composition, and water bulk shield location and material selection

Thermal structural analysis of SST-1 vacuum vessel and cryostat assembly using ANSYS

International Nuclear Information System (INIS)

Santra, Prosenjit; Bedakihale, Vijay; Ranganath, Tata

2009-01-01

Steady state super-conducting tokamak-1 (SST-1) is a medium sized tokamak, which has been designed to produce a 'D' shaped double null divertor plasma and operate in quasi steady state (1000 s). SST-1 vacuum system comprises of plasma chamber (vacuum vessel, interconnecting rings, baking and cooling channels), and cryostat all made of SS 304L material designed to meet ultra high vacuum requirements for plasma generation and confinement. Prior to plasma shot and operation the vessel assembly is baked to 250/150 deg. C from room temperature and discharge cleaned to remove impurities/trapped gases from wall surfaces. Due to baking the non-uniform temperature pattern on the vessel assembly coupled with atmospheric pressure loading and self-weight give rise to high thermal-structural stresses, which needs to be analyzed in detail. In addition the vessel assembly being a thin shell vessel structure needs to be checked for critical buckling load caused by atmospheric and baking thermal loads. Considering symmetry of SST-1, 1/16th of the geometry is modeled for finite element (FE) analysis using ANSYS for different loading scenarios, e.g. self-weight, pressure loading considering normal operating conditions, and off-normal loads coupled with baking of vacuum vessel from room temperature 250 deg. C to 150 deg. C, buckling and modal analysis for future dynamic analysis. The paper will discuss details about SST-1 vacuum system/cryostat, solid and FE model of SST-1, different loading scenarios, material details and the stress codes used. We will also present the thermal structural results of FE analysis using ANSYS for various load cases being investigated and our observations under different loading conditions.

Novel method of aligning ATF-1 coils

International Nuclear Information System (INIS)

Rome, J.A.; Harris, J.H.; Neilson, G.H.; Jernigan, T.C.

1983-08-01

The coils for the Advanced Toroidal Facility (ATF-1) torsatron may be easily aligned before the machine is placed under vacuum. This is done by creating nulls in the magnetic field by energizing the coils in various configurations. All of the nulls in vertical bar B vector vertical bar occur on the z-axis. When the nulls coincide, the coils are properly aligned

Recovery process of wall condition in KSTAR vacuum vessel after temporal machine-vent for repair

Energy Technology Data Exchange (ETDEWEB)

Kim, Kwang Pyo, E-mail: kpkim@nfri.er.ke; Hong, Suk-Ho; Lee, Hyunmyung; Song, Jae-in; Jung, Nam-Yong; Lee, Kunsu; Chu, Yong; Kim, Hakkun; Park, Kaprai; Oh, Yeong-Kook

2015-10-15

Highlights: • Efforts have been made to obtain vacuum condition that is essential for the plasma experiments. • For example, the vacuum vessel should be vented to repair in-vessel components such as diagnostic shutter, and PFC damaged by high energy plasma. • Here, we present the recovery process of wall condition in KSTAR after temporal machine-vent for repair. • It is found that an acceptable vacuum condition has been achieved only by plasma based wall conditioning techniques such as baking, GDC, and boronization. • This study was that the proper recovering method of the vacuum condition should be developed according to the severity of the accident. - Abstract: Efforts have been made to obtain vacuum condition that is essential for the plasma experiments. Under certain situations, for example, the vacuum vessel should be vented to repair in-vessel components such as diagnostic shutter, exchange of window for diagnostic equipment, and PFC damaged by high energy plasma. For the quick restart of the campaign, a recovery process was established to make the vacuum condition acceptable for the plasma experiment. In this paper, we present the recovery process of wall condition in KSTAR after temporal machine-vent for repair. It is found that an acceptable vacuum condition has been achieved only by plasma based wall conditioning techniques such as baking, GDC, and boronization. This study was that the proper recovering method of the vacuum condition should be developed according to the severity of the accident.

Adenoviral gene transfer of angiostatic ATF-BPTI inhibits tumour growth

International Nuclear Information System (INIS)

Lefesvre, Pierre; Attema, Joline; Bekkum, Dirk van

2002-01-01

The outgrowth of new vessels – angiogenesis – in the tumour mass is considered to be a limiting factor of tumour growth. To inhibit the matrix lysis that is part of the tumour angiogenesis, we employed the chimeric protein mhATF-BPTI, composed of the receptor binding part of the urokinase (ATF) linked to an inhibitor of plasmin (BPTI). For delivery, recombinant adenovirus encoding the transgene of interest was injected intravenously or locally into the tumour. The anti tumour effect of this compound was compared to that of human endostatin and of mhATF alone in two different rat bronchial carcinomas growing either as subcutaneous implants or as metastases. Significant inhibition of the tumour growth and decrease of the number of lung metastasis was achieved when the concentration of mhATF-BPTI at the tumour site was above 400 of ng / g tissue. This concentration could be achieved via production by the liver, only if permissive to the recombinant adenovirus. When the tumour cells could be transduced, local delivery of the vector was enough to obtain a response. In the case of metastasis, the capacity of the lung tissue to concentrate the encoded protein was essential to reach the required therapeutic levels. Further, endostatin or mhATF could not reproduce the effects of mhATF-BPTI, at similar concentrations (mhATF) and even at 10-fold higher concentration (endostatin). The ATF-BPTI was shown to inhibit tumour growth of different rat lung tumours when critical concentration was reached. In these tumour models, endostatin or ATF induce almost no tumour response

Fabrication of the vacuum vessel of the Spanish stellarator TJ-II

International Nuclear Information System (INIS)

Botija, J.; Blaumoser, M.; Cal, E. de la; Garcia, A.; Tabares, F.; Molleta, L.; Rigadello, D.; Dal Maso, S.; Bevilacqua, G.

1995-01-01

TJ-II is a medium size stellarator under construction in Madrid, Spain. Its major plasma radius is 1.5 m and its minor plasma dimensions are 0.2m by 0.4m. The toroidal magnetic field on the axis is 1T. The bean shaped helical plasma is contained in a stainless steel vacuum vessel with a total of 96 ports, including 8 manholes to have access to its interior. The vacuum vessel will be baked at 150 C. Its complicated geometry along with the high tolerance requirements make this component a difficult manufacturing challenge. (orig.)

Structural analysis and manufacture for the vacuum vessel of experimental advanced superconducting tokamak (EAST) device

International Nuclear Information System (INIS)

Song Yuntao; Yao Damao; Wu Songata; Weng Peide

2006-01-01

The experimental advanced superconducting tokamak (EAST) is an advanced steady-state plasma physics experimental device, which has been approved by the Chinese government and is being constructed as the Chinese national nuclear fusion research project. The vacuum vessel, that is one of the key components, will have to withstand not only the electromagnetic force due to the plasma disruption and the Halo current, but also the pressure of boride water and the thermal stress due to the 250 deg. C baking out by the hot pressure nitrogen gas, or the 100 deg. C hot wall during plasma operation. This paper is a report of the mechanical analyses of the vacuum vessel. According to the allowable stress criteria of American Society of Mechanical Engineers, Boiler and Pressure Vessel Committee (ASME), the maximum integrated stress intensity on the vacuum vessel is 396 MPa, less than the allowable design stress intensity 3S m (441 MPa). At the same time, some key R and D issues are presented, which include supporting system, bellows and the assembly of the whole vacuum vessel

Plasma discharge in ferritic first wall vacuum vessel of the Hitachi Tokamak HT-2

International Nuclear Information System (INIS)

Abe, Mitsushi; Nakayama, Takeshi; Asano, Katsuhiko; Otsuka, Michio

1997-01-01

A tokamak discharge with ferritic material first wall was tried successfully. The Hitachi Tokamak HT-2 had a stainless steel SUS304 vacuum vessel and modified to have a ferritic plate first wall for experiments to investigate the possibility of ferritic material usage in magnetic fusion devices. The achieved vacuum pressure and times used for discharge cleaning was roughly identical with the stainless steel first wall or the original HT-2. We concluded that ferritic material vacuum vessel is possible for tokamaks. (author)

ITER vacuum vessel structural analysis completion during manufacturing phase

Energy Technology Data Exchange (ETDEWEB)

Martinez, J.-M., E-mail: jean-marc.martinez@live.fr [ITER Organization, Route Vinon sur Verdon, CS 90046, 13067, St. Paul lez Durance, Cedex (France); Alekseev, A.; Sborchia, C.; Choi, C.H.; Utin, Y.; Jun, C.H.; Terasawa, A.; Popova, E.; Xiang, B.; Sannazaro, G.; Lee, A.; Martin, A.; Teissier, P.; Sabourin, F. [ITER Organization, Route Vinon sur Verdon, CS 90046, 13067, St. Paul lez Durance, Cedex (France); Caixas, J.; Fernandez, E.; Zarzalejos, J.M. [F4E, c/Josep Pla, n.2, Torres Diagonal Litoral, Edificio B3, E-08019, Barcelona (Spain); Kim, H.-S.; Kim, Y.G. [ITER Korea, National Fusion Research Institute, Daejeon (Korea, Republic of); Privalova, E. [NTC “Sintez”, Efremov Inst., 189631 Metallostroy, St. Petersburg (Russian Federation); and others

2016-11-01

Highlights: • ITER Vacuum Vessel (VV) is a part of the first barrier to confine the plasma. • A Nuclear Pressure Equipment necessitates Agreed Notified Body to assure design, fabrication, and conformance testing and quality assurance. • Some supplementary RCC-MR margin targets have been considered to guarantee considerable structural margins in areas not inspected in operation. • Many manufacturing deviation requests (MDR) and project change requests (PCR) impose to re-evaluate the structural margin. • Several structural analyses were performed with global and local models to guarantee the structural integrity of the whole ITER Vacuum Vessel. - Abstract: Some years ago, analyses were performed by ITER Organization Central Team (IO-CT) to verify the structural integrity of the ITER vacuum vessel baseline design fixed in 2010 and classified as a Protection Important Component (PIC). The manufacturing phase leads the ITER Organization domestic agencies (IO-DA) and their contracted manufacturers to propose detailed design improvements to optimize the manufacturing or inspection process. These design and quality inspection changes can affect the structural margins with regards to the Codes&Standards and thus oblige to evaluate one more time the modified areas. This paper proposes an overview of the additional analyses already performed to guarantee the structural integrity of the manufacturing designs. In this way, CT and DAs have been strongly involved to keep the considerable margins obtained previously which were used to fix reasonable compensatory measures for the lack of In Service Inspections of a Nuclear Pressure Equipment (NPE).

ITER vacuum vessel structural analysis completion during manufacturing phase

International Nuclear Information System (INIS)

Martinez, J.-M.; Alekseev, A.; Sborchia, C.; Choi, C.H.; Utin, Y.; Jun, C.H.; Terasawa, A.; Popova, E.; Xiang, B.; Sannazaro, G.; Lee, A.; Martin, A.; Teissier, P.; Sabourin, F.; Caixas, J.; Fernandez, E.; Zarzalejos, J.M.; Kim, H.-S.; Kim, Y.G.; Privalova, E.

2016-01-01

Highlights: • ITER Vacuum Vessel (VV) is a part of the first barrier to confine the plasma. • A Nuclear Pressure Equipment necessitates Agreed Notified Body to assure design, fabrication, and conformance testing and quality assurance. • Some supplementary RCC-MR margin targets have been considered to guarantee considerable structural margins in areas not inspected in operation. • Many manufacturing deviation requests (MDR) and project change requests (PCR) impose to re-evaluate the structural margin. • Several structural analyses were performed with global and local models to guarantee the structural integrity of the whole ITER Vacuum Vessel. - Abstract: Some years ago, analyses were performed by ITER Organization Central Team (IO-CT) to verify the structural integrity of the ITER vacuum vessel baseline design fixed in 2010 and classified as a Protection Important Component (PIC). The manufacturing phase leads the ITER Organization domestic agencies (IO-DA) and their contracted manufacturers to propose detailed design improvements to optimize the manufacturing or inspection process. These design and quality inspection changes can affect the structural margins with regards to the Codes&Standards and thus oblige to evaluate one more time the modified areas. This paper proposes an overview of the additional analyses already performed to guarantee the structural integrity of the manufacturing designs. In this way, CT and DAs have been strongly involved to keep the considerable margins obtained previously which were used to fix reasonable compensatory measures for the lack of In Service Inspections of a Nuclear Pressure Equipment (NPE).

Design, fabrication and test of double-wall vacuum vessel for JT-60U

International Nuclear Information System (INIS)

Uchikawa, Takashi; Ioki, Kimihiro; Ninomiya, Hiromasa.

1994-01-01

A double-wall vacuum vessel was designed and fabricated for JT-60U (an upgraded machine of JT-60), which has a plasma current up to 6 MA and a large plasma volume (100 m 3 ). A new concept of Inconel 625 all-welded structure was adopted to the vessel, that comprises an inner plate, square tubes and an outer plate. The vacuum vessel with a multi-arc D-shaped cross section was fabricated by using hot-sizing press. The electromagnetic and structural analysis has been performed for plasma disruption loads. Dynamic responses of the vessel were measured during plasma disruptions, and the observed displacement had a good agreement with the result of FEM analysis. (author)

Structural analysis of the KSTAR vacuum vessel

Energy Technology Data Exchange (ETDEWEB)

In, Sang Ryul; Yoon, Byeong Joo [Korea Atomic Energy Research Institute, Taejon (Korea)

1998-10-01

Structure analysis of the vacuum vessel for the KSTAR tokamak which, is in the end phase of the conceptual design have been performed. Mechanical stresses and deformations of the vessel produced by constant forces due to atmospheric pressure, dead weight, fluid pressure, etc and various transient electromagnetic forces induced during tokamak operations were calculated as well as modal characteristics and buckling properties were investigated. Influences of the temperature gradient and the constraint condition of the support on the thermal stress and deformation of the vessel were analyzed. The thermal stress due to the temperature distribution on the vessel as supplying the N{sub 2} gas of 400 deg C through poloidal channels according to the recent baking concept were calculated. No severe problem in the robustness of the vessel was found when applying the constant pressures on the vessel. However the mechanical stress due to the EM force induced by halo currents flowing on the vessel and the plasma facing components (PFCs) far exceeded the allowable limit. Some reinforcing components should be added on the boundary of the PFC support and the vessel, and that of the vessel support and the vessel. A steep temperature gradient in the vicinity of the inlet and oulet of the heating gas produced a thermal stress much higher than allowable. It is necessary to make the temperature of the vessel as uniform as possible and to develop a new support concept which is flexible enough to accommodate a thermal expansion of a few cm while sufficiently strong to resist mechanical impacts. (author). 5 refs., 41 figs., 9 tabs.

Vacuum vessel for a nuclear fusion device

International Nuclear Information System (INIS)

Watanabe, Takashi; Sato, Hiroshi; Owada, Koro.

1976-01-01

Object: To provide a reinforcing member on a bellows portion to reduce a stress at the bellows portion thereby increasing the strength of a vessel. Structure: A vacuum vessel for a nuclear fusion device has a bellows portion and a wall thick portion. A support extended toward the bellows portion is secured inside of a toroidal section in order to reduce the stress at the bellows portion. An insulator is interposed between the support and the bellows portion and is retained on the support by a bolt. Since the stress may be reduced by the support, the wall thick of the bellows portion may be decreased to sufficiently secure the low electric resistance value. (Yoshihara, H.)

JT-60SA vacuum vessel manufacturing and assembly

Energy Technology Data Exchange (ETDEWEB)

Masaki, Kei, E-mail: masaki.kei@jaea.go.jp [Japan Atomic Energy Agency, Naka, Ibaraki-ken 311-0193 (Japan); Shibama, Yusuke K.; Sakurai, Shinji; Shibanuma, Kiyoshi; Sakasai, Akira [Japan Atomic Energy Agency, Naka, Ibaraki-ken 311-0193 (Japan)

2012-08-15

Highlights: Black-Right-Pointing-Pointer The design of the JT-60SA vacuum vessel body was completed with the demonstration of manufacturing procedure by the mock-up fabrication of the 20 Degree-Sign upper half of VV. Black-Right-Pointing-Pointer The actual VV manufacturing has started since November 2009. Black-Right-Pointing-Pointer The first product of the VV 40 Degree-Sign sector was completed in May 2011. Black-Right-Pointing-Pointer A basic VV assembly scenario and procedure were studied to complete the 360 Degree-Sign VV including positioning method and joint welding. - Abstract: The JT-60SA vacuum vessel (VV) has a D-shaped poloidal cross section and a toroidal configuration with 10 Degree-Sign segmented facets. A double wall structure is adopted to ensure high rigidity at operational load and high toroidal one-turn resistance. The material is 316L stainless steel with low cobalt content (<0.05%). The design temperatures of the VV at plasma operation and baking are 50 Degree-Sign C and 200 Degree-Sign C, respectively. In the double wall, boric-acid water is circulated at plasma operation to reduce the nuclear heating of the superconducting magnets. For baking, nitrogen gas is circulated in the double wall after draining of the boric-acid water. The manufacturing of the VV started in November 2009 after a fundamental welding R and D and a trial manufacturing of 20 Degree-Sign upper half mock-up. The manufacturing of the first VV 40 Degree-Sign sector was completed in May 2011. A basic concept and required jigs of the VV assembly were studied. This paper describes the design and manufacturing of the vacuum vessel. A plan of VV assembly in torus hall is also presented.

Demonstration tests for manufacturing the ITER vacuum vessel

International Nuclear Information System (INIS)

Shimizu, Katsusuke; Onozuka, Masanori; Usui, Yukinori; Urata, Kazuhiro; Tsujita, Yoshihiro; Nakahira, Masataka; Takeda, Nobukazu; Kakudate, Satoshi; Ohmori, Junji; Shibanuma, Kiyoshi

2007-01-01

Demonstration tests for manufacturing and assembly of the International Thermonuclear Experimental Reactor (ITER) vacuum vessel have been conducted to confirm manufacturing and assembly process of the vacuum vessel (VV). The full-scale partial mock-up fabrication was planned and is in progress. The results will be available in the near future. Field-joint assembly procedure has been demonstrated using a test stand. Due to limited accessibility to the outer shell at the field joint, some operations, including alignment of the splice plates, field-joint welding, and examination, were found to be very difficult. In addition, a demonstration test on the selected back-seal structures was performed. It was found that the tested structures have insufficient sealing capabilities and need further improvement. The applicability of ultrasonic testing methods has been investigated. Although side drilled holes of 2.4 mm in diameter were detected, detection of the slit-type defects and defect characterization were found to be difficult. Feasibility test of liquid penetrant testing has revealed that the selected liquid penetrant testing (LPT) solutions have sufficient low outgas rates and are applicable to the VV

Demonstration tests for manufacturing the ITER vacuum vessel

Energy Technology Data Exchange (ETDEWEB)

Shimizu, Katsusuke [Mitsubishi Heavy Industries, Ltd., Kobe Shipyard and Machinery Works, Wadasaki-cho 1-1-1, Hyogo-ku, Kobe 652-8585 (Japan)], E-mail: katsusuke_shimizu@mhi.co.jp; Onozuka, Masanori [Mitsubishi Heavy Industries, Ltd., Konan 2-16-5, Minato-ku, Tokyo 108-8215 (Japan); Usui, Yukinori; Urata, Kazuhiro; Tsujita, Yoshihiro [Mitsubishi Heavy Industries, Ltd., Kobe Shipyard and Machinery Works, Wadasaki-cho 1-1-1, Hyogo-ku, Kobe 652-8585 (Japan); Nakahira, Masataka; Takeda, Nobukazu; Kakudate, Satoshi; Ohmori, Junji; Shibanuma, Kiyoshi [Japan Atomic Energy Agency, Mukouyama 801-1, Naka-machi, Naka-gun, Ibaraki 311-0193 (Japan)

2007-10-15

Demonstration tests for manufacturing and assembly of the International Thermonuclear Experimental Reactor (ITER) vacuum vessel have been conducted to confirm manufacturing and assembly process of the vacuum vessel (VV). The full-scale partial mock-up fabrication was planned and is in progress. The results will be available in the near future. Field-joint assembly procedure has been demonstrated using a test stand. Due to limited accessibility to the outer shell at the field joint, some operations, including alignment of the splice plates, field-joint welding, and examination, were found to be very difficult. In addition, a demonstration test on the selected back-seal structures was performed. It was found that the tested structures have insufficient sealing capabilities and need further improvement. The applicability of ultrasonic testing methods has been investigated. Although side drilled holes of 2.4 mm in diameter were detected, detection of the slit-type defects and defect characterization were found to be difficult. Feasibility test of liquid penetrant testing has revealed that the selected liquid penetrant testing (LPT) solutions have sufficient low outgas rates and are applicable to the VV.

Role of Outgassing of ITER Vacuum Vessel In-Wall Shielding Materials in Leak Detection of ITER Vacuum Vessel

Science.gov (United States)

Maheshwari, A.; Pathak, H. A.; Mehta, B. K.; Phull, G. S.; Laad, R.; Shaikh, M. S.; George, S.; Joshi, K.; Khan, Z.

2017-04-01

ITER Vacuum Vessel is a torus-shaped, double wall structure. The space between the double walls of the VV is filled with In-Wall Shielding Blocks (IWS) and Water. The main purpose of IWS is to provide neutron shielding during ITER plasma operation and to reduce ripple of Toroidal Magnetic Field (TF). Although In-Wall Shield Blocks (IWS) will be submerged in water in between the walls of the ITER Vacuum Vessel (VV), Outgassing Rate (OGR) of IWS materials plays a significant role in leak detection of Vacuum Vessel of ITER. Thermal Outgassing Rate of a material critically depends on the Surface Roughness of material. During leak detection process using RGA equipped Leak detector and tracer gas Helium, there will be a spill over of mass 3 and mass 2 to mass 4 which creates a background reading. Helium background will have contribution of Hydrogen too. So it is necessary to ensure the low OGR of Hydrogen. To achieve an effective leak test it is required to obtain a background below 1 × 10-8 mbar 1 s-1 and hence the maximum Outgassing rate of IWS Materials should comply with the maximum Outgassing rate required for hydrogen i.e. 1 x 10-10 mbar 1 s-1 cm-2 at room temperature. As IWS Materials are special materials developed for ITER project, it is necessary to ensure the compliance of Outgassing rate with the requirement. There is a possibility of diffusing the gasses in material at the time of production. So, to validate the production process of materials as well as manufacturing of final product from this material, three coupons of each IWS material have been manufactured with the same technique which is being used in manufacturing of IWS blocks. Manufacturing records of these coupons have been approved by ITER-IO (International Organization). Outgassing rates of these coupons have been measured at room temperature and found in acceptable limit to obtain the required Helium Background. On the basis of these measurements, test reports have been generated and got

ATF2 Commissioning

Energy Technology Data Exchange (ETDEWEB)

Seryi, A.; /SLAC; Christian, G.; /KLTE-ATOMKI; Parker, B.; /BNL; Schulte, D.; Delahaye, J.-P.; Tomas, R.; Zimmermann, F.; /CERN; Wolski, A.; Elsen, E.; /Cockcroft Inst. /DESY; Sanuki, T.; /Tohoku U.; Gianfelice-Wendt, E.; Ross, M.; Wendt, M.; /Fermilab; Takahashi, T.; /Hiroshima U.; Bai, S.; Gao, J.; /Beijing, Inst. High Energy Phys.; Bolzon, B.; Geffroy, N.; Jeremie, A.; /Annecy, LAPP; Apsimon, R.; Burrows, P.; /Oxford U., JAI /Kyoto U., Inst. Chem. Res. /Kyungpook Natl. U. /Orsay, LAL /Phang Accelerator Lab /Royal Holloway, U. of London /SLAC /Daresbury /University Coll. London /Manchester U. /Univ. of Tokyo U.

2009-10-30

ATF2 is a final-focus test beam line that aims to focus the low-emittance beam from the ATF damping ring to a beam size of about 37 nm, and at the same time to demonstrate nm beam stability, using numerous advanced beam diagnostics and feedback tools. The construction has been finished at the end of 2008 and the beam commissioning of ATF2 has started in December of 2008. ATF2 is constructed and commissioned by ATF international collaborations with strong US, Asian and European participation.

ATF2 COMMISSIONING

CERN Document Server

Seryi, A; Parker, B; Schulte, D; Delahaye, J P; Tomas, R; Zimmermann, F; Wolski, A; Elsen, E; Sanuki, T; Gianfelice-Wendt, E; Ross, M; Wendt, M; Takahashi, T; Bai, S; Gao, J; Bolzon, B; Geffroy, N; Jeremie, A; Apsimon, R; Burrows, P; Constance, B; Perry, C; Resta-Lopez, J; Swinson, C; Araki, S; Aryshev, A; Hayano, H; Honda, Y; Kubo, K; Kume, T; Kuroda, S; Masuzawa, M; Naito, T; Okugi, T; Sugahara, R; Tauchi, T; Terunuma, N; Urakawa, J; Yokoya, K; Iwashita, Y; Sugimoto, T; Heo, A Y; Kim, E S; Kim, H S; Bambade, P; Renier, Y; Rimbault, C; Huang, J Y; Kim, S H; Park, Y J; Hwang, W H; Blair, G; Boogert, S; Karataev, P; Molloy, S; Amann, J; Bellomo, P; Lam, B; McCormick, D; Nelson, J; Paterson, E; Pivi, M; Raubenheimer, T; Spencer, C; Wang, M H; White, G; Wittmer, W; Woodley, M; Yan, Y; Zhou, F; Angal-Kalinin, D; Jones, J; Lyapin, A; Scarfe, A; Kamiya, Y; Komamiya, S; Oroku, M; Suehara, T; Yamanaka, T

2010-01-01

ATF2 is a final-focus test beam line that aims to focus the low-emittance beam from the ATF damping ring to a beam size of about 37 nm, and at the same time to demonstrate nm beam stability, using numerous advanced beam diagnostics and feedback tools. The construction has been finished at the end of 2008 and the beam commissioning of ATF2 has started in December of 2008. ATF2 is constructed and commissioned by ATF international collaborations with strong US, Asian and European participation.

Mechanical Property and Oxidation Behavior of ATF cladding developed in KAERI

Energy Technology Data Exchange (ETDEWEB)

Kim, Hyun-Gil; Kim, Il-Hyun; Jung, Yang-Il; Park, Dong-Jun; Park, Jung-Hwan; Park, Jeong-Yong; Koo, Yang-Hyun [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2015-10-15

To realize the coating cladding, coating material (Cr-based alloy) as well as coating technology (3D laser coating and arc ion plating combined with vacuum annealing) can be developed to meet the fuel cladding criteria. The coated Zr cladding can be produced after the optimization of coating technologies. The coated cladding sample showed the good oxidation/corrosion and adhesion properties without the spalling and/or severe interaction with the Zr alloy cladding from the various tests. Thus, it is known that the mechanical property and oxidation behavior of coated cladding concept developed in KAERI is reasonable for applying the ATF cladding in LWRs. At the present time various ATF concepts have been proposed and developing in many countries. The ATF concepts with potentially improved accident performance can be summarized to the coating cladding, Mo-Zr cladding, FeCrAl cladding, and SiCf/SiC cladding. Regarding the cladding performance, ATF cladding concepts will be evaluated with respect to the accident scenarios and normal operations of LWRs as well as to the fuel cladding fabrication.

Thick SS316 materials TIG welding development activities towards advanced fusion reactor vacuum vessel applications

Science.gov (United States)

Kumar, B. Ramesh; Gangradey, R.

2012-11-01

Advanced fusion reactors like ITER and up coming Indian DEMO devices are having challenges in terms of their materials design and fabrication procedures. The operation of these devices is having various loads like structural, thermo-mechanical and neutron irradiation effects on major systems like vacuum vessel, divertor, magnets and blanket modules. The concept of double wall vacuum vessel (VV) is proposed in view of protecting of major reactor subsystems like super conducting magnets, diagnostic systems and other critical components from high energy 14 MeV neutrons generated from fusion plasma produced by D-T reactions. The double walled vacuum vessel is used in combination with pressurized water circulation and some special grade borated steel blocks to shield these high energy neutrons effectively. The fabrication of sub components in VV are mainly used with high thickness SS materials in range of 20 mm- 60 mm of various grades based on the required protocols. The structural components of double wall vacuum vessel uses various parts like shields, ribs, shells and diagnostic vacuum ports. These components are to be developed with various welding techniques like TIG welding, Narrow gap TIG welding, Laser welding, Hybrid TIG laser welding, Electron beam welding based on requirement. In the present paper the samples of 20 mm and 40 mm thick SS 316 materials are developed with TIG welding process and their mechanical properties characterization with Tensile, Bend tests and Impact tests are carried out. In addition Vickers hardness tests and microstructural properties of Base metal, Heat Affected Zone (HAZ) and Weld Zone are done. TIG welding application with high thick SS materials in connection with vacuum vessel requirements and involved criticalities towards welding process are highlighted.

Thick SS316 materials TIG welding development activities towards advanced fusion reactor vacuum vessel applications

International Nuclear Information System (INIS)

Kumar, B Ramesh; Gangradey, R

2012-01-01

Advanced fusion reactors like ITER and up coming Indian DEMO devices are having challenges in terms of their materials design and fabrication procedures. The operation of these devices is having various loads like structural, thermo-mechanical and neutron irradiation effects on major systems like vacuum vessel, divertor, magnets and blanket modules. The concept of double wall vacuum vessel (VV) is proposed in view of protecting of major reactor subsystems like super conducting magnets, diagnostic systems and other critical components from high energy 14 MeV neutrons generated from fusion plasma produced by D-T reactions. The double walled vacuum vessel is used in combination with pressurized water circulation and some special grade borated steel blocks to shield these high energy neutrons effectively. The fabrication of sub components in VV are mainly used with high thickness SS materials in range of 20 mm- 60 mm of various grades based on the required protocols. The structural components of double wall vacuum vessel uses various parts like shields, ribs, shells and diagnostic vacuum ports. These components are to be developed with various welding techniques like TIG welding, Narrow gap TIG welding, Laser welding, Hybrid TIG laser welding, Electron beam welding based on requirement. In the present paper the samples of 20 mm and 40 mm thick SS 316 materials are developed with TIG welding process and their mechanical properties characterization with Tensile, Bend tests and Impact tests are carried out. In addition Vickers hardness tests and microstructural properties of Base metal, Heat Affected Zone (HAZ) and Weld Zone are done. TIG welding application with high thick SS materials in connection with vacuum vessel requirements and involved criticalities towards welding process are highlighted.

Structural design of shield-integrated thin-wall vacuum vessel and manufacturing qualification tests for International Thermonuclear Experimental Reactor (ITER)

International Nuclear Information System (INIS)

Shimizu, Katsusuke; Shibui, Masanao; Koizumi, Koichi; Kanamori, Naokazu; Nishio, Satoshi; Sasaki, Takashi; Tada, Eisuke

1992-09-01

Conceptual design of shield-integrated thin-wall vacuum vessel has been done for ITER (International Thermonuclear Experimental Reactor). The vacuum vessel concept is based on a thin-double-wall structure, which consists of inner and outer plates and rib stiffeners. Internal shielding structures, which provide neutron irradiation shielding to protect TF coils, are set up between the inner plate and the outer plate of the vessel to avoid complexity of machine systems such as supporting systems of blanket modules. The vacuum vessel is assembled/disassembled by remote handling, so that welding joints are chosen as on-site joint method from reliability of mechanical strength. From a view point of assembling TF coils, the vacuum vessel is separated at the side of port, and is divided into 32 segments similar to the ITER-CDA reference design. Separatrix sweeping coils are located in the vacuum vessel to reduce heat fluxes onto divertor plates. Here, the coil structure and attachment to the vacuum vessel have been investigated. A sectorized saddle-loop coil is available for assembling and disassembling the coil. To support electromagnetic loads on the coils, they are attached to the groove in the vacuum vessel by welding. Flexible multi-plate supporting structure (compression-type gravity support), which was designed during CDA, is optimized by investigating buckling and frequency response properties, and concept on manufacturing and fabrication of the gravity support are proposed. Partial model of the vacuum vessel is manufactured for trial, so that fundamental data on welding and fabrication are obtained. From mechanical property tests of weldment and partial models, mechanical intensity and behaviors of the weldment are obtained. Informations on FEM-modeling are obtained by comparing analysis results with experimental results. (author)

ITER vacuum vessel dynamic stress analysis of a disruption

International Nuclear Information System (INIS)

Riemer, B.W.; Conner, D.L.; Strickler, D.J.; Williamson, D.E.

1994-01-01

Dynamic stress analysis of the International Thermonuclear Experimental Reactor vacuum vessel loaded by disruption forces was performed. The deformation and stress results showed strong inertial effects when compared to static analyses. Maximum stress predicted dynamically was 300 MPa, but stress shown by static analysis from loads at the same point in time reached only 80 MPa. The analysis also provided a reaction load history in the vessel's supports which is essential in evaluating support design. The disruption forces were estimated by assuming a 25-MA plasma current decaying at 1 MA/ms while moving vertically. In addition to forces developed within the vessel, vertical loadings from the first wall/strong back assemblies and the divertor were applied to the vessel at their attachment points. The first 50 natural modes were also determined. The first mode's frequency was 6.0 Hz, and its shape is characterized by vertical displacement of the vessel inner leg. The predicted deformation of the vessel appeared similar to its first mode shape combined with radial contraction. Kinetic energy history from the analysis also correlated with the first mode frequency

Blanket and vacuum vessel design of the next tokamak. (Swimming pool type)

International Nuclear Information System (INIS)

Iida, H.; Minato, A.; Kitamura, K.

1983-01-01

The structural design study of a reactor module for a swimming pool type reactor (SPTR) was conducted. Since pool water plays the role of radiation shielding in the SPTR, the module does not have a solid shield. It consists of tritium breeding blankets, divertor collector plates and a vacuum vessel. The object of this study is to show the reactor module design which has a simple structure and a sufficient tritium breeding ratio. A large coverage of the plasma chamber surface with tritium breeding blanket is essential in order to obtain a high tritium breeding ratio. A breeding blanket is also placed behind the divertor collector plate, i.e. in the upper and lower region, as well as in the outboard and inboard regions of the module. A concept in which the first wall is an integral part of the blanket is employed to minimize the thickness of structural and cooling material brazed in front of the breeding material (Li 2 O) and to enhance the tritium breeding capability. In order to simplify the module structure the vacuum vessel and breeding blanket is also integrated in the inboard region. One of the features inherent in the swimming pool type reactor is an additional external force on the vacuum vessel, namely hydraulic pressure. A detailed structural analysis of the vacuum vessel is performed. Divertor collector plates are assemblies of co-axial tubes. They minimize the electromagnetic force on the plate induced by the plasma disruption. A thermal and structural analysis and life time estimation of the first wall and divertor collector plates are performed. (author)

Project management techniques used in the European Vacuum Vessel sectors procurement for ITER

Energy Technology Data Exchange (ETDEWEB)

Losasso, Marcello, E-mail: marcello.losasso@f4e.europa.eu [Fusion for Energy (F4E), Barcelona (Spain); Ortiz de Zuniga, Maria; Jones, Lawrence; Bayon, Angel; Arbogast, Jean-Francois; Caixas, Joan; Fernandez, Jose; Galvan, Stefano; Jover, Teresa [Fusion for Energy (F4E), Barcelona (Spain); Ioki, Kimihiro [ITER Organisation, Route de Vinon sur Verdon, 13115 Saint Paul Lez Durance (France); Lewczanin, Michal; Mico, Gonzalo; Pacheco, Jose Miguel [Fusion for Energy (F4E), Barcelona (Spain); Preble, Joseph [ITER Organisation, Route de Vinon sur Verdon, 13115 Saint Paul Lez Durance (France); Stamos, Vassilis; Trentea, Alexandru [Fusion for Energy (F4E), Barcelona (Spain)

2012-08-15

Highlights: Black-Right-Pointing-Pointer File name contains the directory tree structure with a string of three-letter acronyms, thereby enabling parent directory location when confronted with orphan files. Black-Right-Pointing-Pointer The management of the procurement procedure was carried out in an efficient and timely manner, achieving precisely the contract placement date foreseen at the start of the process. Black-Right-Pointing-Pointer The contract start-up has been effectively implemented and a flexible project management system has been put in place for an efficient monitoring of the contract. - Abstract: The contract for the seven European Sectors of the ITER Vacuum Vessel (VV) was placed at the end of 2010 with a consortium of three Italian companies. The task of placing and the initial take-off of this large and complex contract, one of the largest placed by F4E, the European Domestic Agency for ITER, is described. A stringent quality controlled system with a bespoke Vacuum Vessel Project Lifecycle Management system to control the information flow, based on ENOVIA SmarTeam, was developed to handle the storage and approval of Documentation including links to the F4E Vacuum Vessel system and ITER International Organization System interfaces. The VV Sector design and manufacturing schedule is based on Primavera software, which is cost loaded thus allowing F4E to carry out performance measurement with respect to its payments and commitments. This schedule is then integrated into the overall Vacuum Vessel schedule, which includes ancillary activities such as instruments, preliminary design and analysis. The VV Sector Risk Management included three separate risk analyses from F4E and the bidders, utilizing two different methodologies. These efforts will lead to an efficient and effective implementation of this contract, vital to the success of the ITER machine, since the Vacuum Vessel is the biggest single work package of Europe's contribution to ITER and

Vacuum vessel port structures for ITER-FEAT

International Nuclear Information System (INIS)

Utin, Yu.; Ioki, K.; Komarov, V.; Krylov, V.; Kuzmin, E.; Labusov, I.; Miki, N.; Onozuka, M.; Rozov, V.; Sannazzaro, G.; Tesini, A.; Yamada, M.; Barthel, Th.

2001-01-01

The equatorial and the upper port structures are the most loaded among those of the ITER-FEAT vacuum vessel (VV). For all of these ports, the VV closure plate and the in-port components are integrated into the port plug. The plugs/port structures are affected by plasma events and must withstand high mechanical loads. Based on typical port plugs, this paper presents the conceptual design of the port structures (with emphasis on the supporting system), and the results of analyses performed

Vacuum vessel port structures for ITER-FEAT

Energy Technology Data Exchange (ETDEWEB)

Utin, Yu.; Ioki, K.; Komarov, V.; Krylov, V.; Kuzmin, E.; Labusov, I.; Miki, N.; Onozuka, M.; Rozov, V.; Sannazzaro, G.; Tesini, A.; Yamada, M.; Barthel, Th

2001-11-01

The equatorial and the upper port structures are the most loaded among those of the ITER-FEAT vacuum vessel (VV). For all of these ports, the VV closure plate and the in-port components are integrated into the port plug. The plugs/port structures are affected by plasma events and must withstand high mechanical loads. Based on typical port plugs, this paper presents the conceptual design of the port structures (with emphasis on the supporting system), and the results of analyses performed.

Dutch supplier rewarded for manufacture of the two vacuum vessels for the ATLAS end-cap toroids

CERN Multimedia

Maximilien Brice

2003-01-01

The ATLAS collaboration has presented an award for outstanding supplier performance to Dutch firm Schelde Exotech. Based on a design by Rutherford Appleton Laboratory, UK, Schelde Exotech manufactured under a NIKHEF contract the two 500 m3 large vacuum vessels for the cryostats of the ATLAS end-cap toroids. These 11-metre diameter castellated aluminium vessels with stainless-steel bore tube are essentially made up of 40-mm-thick plates for the shells, 75-mm-thick plates for the endplates, and 150-mm-thick bars for the flanges. Because of transport constraints, the vessels were made in halves, temporarily sealed and vacuum tested at the works, then transported to CERN for final assembly and acceptance tests. Both vessels were vacuum-tight and the meticulous and clean way of working ensured that a high vacuum was obtained within a few days of pumping. The delivery to CERN was completed in July 2002. Representatives of Schelde Exotech are seen here receiving their award in the ATLAS assembly hall. In the backgro...

General and crevice corrosion study of the in-wall shielding materials for ITER vacuum vessel

Science.gov (United States)

Joshi, K. S.; Pathak, H. A.; Dayal, R. K.; Bafna, V. K.; Kimihiro, Ioki; Barabash, V.

2012-11-01

Vacuum vessel In-Wall Shield (IWS) will be inserted between the inner and outer shells of the ITER vacuum vessel. The behaviour of IWS in the vacuum vessel especially concerning the susceptibility to crevice of shielding block assemblies could cause rapid and extensive corrosion attacks. Even galvanic corrosion may be due to different metals in same electrolyte. IWS blocks are not accessible until life of the machine after closing of vacuum vessel. Hence, it is necessary to study the susceptibility of IWS materials to general corrosion and crevice corrosion under operations of ITER vacuum vessel. Corrosion properties of IWS materials were studied by using (i) Immersion technique and (ii) Electro-chemical Polarization techniques. All the sample materials were subjected to a series of examinations before and after immersion test, like Loss/Gain weight measurement, SEM analysis, and Optical stereo microscopy, measurement of surface profile and hardness of materials. After immersion test, SS 304B4 and SS 304B7 showed slight weight gain which indicate oxide layer formation on the surface of coupons. The SS 430 material showed negligible weight loss which indicates mild general corrosion effect. On visual observation with SEM and Metallography, all material showed pitting corrosion attack. All sample materials were subjected to series of measurements like Open Circuit potential, Cyclic polarization, Pitting potential, protection potential, Critical anodic current and SEM examination. All materials show pitting loop in OC2 operating condition. However, its absence in OC1 operating condition clearly indicates the activity of chloride ion to penetrate oxide layer on the sample surface, at higher temperature. The critical pitting temperature of all samples remains between 100° and 200°C.

Dynamic response of the JT-60 vacuum vessel under the electromagnetic forces

International Nuclear Information System (INIS)

Takatsu, H.; Shimizu, M.; Ohta, M.

1982-01-01

Dynamic response analyses of the JAERI Tokamak 60 (JT-60) vacuum vessel were carried out under three kinds of saddle-like electromagnetic forces. In the analysis, the dynamic response of the bellows was obtained by dividing it into three components; the first, caused by the forced deflection due to the displacement of an adjacent rigid ring; the second, caused by inertia force; and the third, caused by a saddle-like electromagnetic force. Eigenvalue analyses showed that the 20th mode is a typical rotation mode of the rigid ring around the major radius with a natural frequency of 46.3 Hz. From the results of the dynamic response analyses, the maximum displacement response of the rigid ring was 3.1 mm and remarkable dynamic response was observed in the case of plasma disruption with a time constant of 1 ms. In cases of start-up of the plasma current and plasma disruption with a time constant of 50 ms, the rigid ring vibrates quasi-statically. It is clear that the dynamic behavior of the vacuum vessel is governed mainly by the saddle-like electromagnetic force, with a smaller effect of the inverse saddle-like electromagnetic force on the dynamic response of the vacuum vessel. (orig.)

Development of a master model concept for DEMO vacuum vessel

International Nuclear Information System (INIS)

Mozzillo, Rocco; Marzullo, Domenico; Tarallo, Andrea; Bachmann, Christian; Di Gironimo, Giuseppe

2016-01-01

Highlights: • The present work concerns the development of a first master concept model for DEMO vacuum vessel. • A parametric-associative CAD master model concept of a DEMO VV sector has been developed in accordance with DEMO design guidelines. • A proper CAD design methodology has been implemented in view of the later FEM analyses based on “shell elements”. - Abstract: This paper describes the development of a master model concept of the DEMO vacuum vessel (VV) conducted within the framework of the EUROfusion Consortium. Starting from the VV space envelope defined in the DEMO baseline design 2014, the layout of the VV structure was preliminarily defined according to the design criteria provided in RCC-MRx. A surface modelling technique was adopted and efficiently linked to the finite element (FE) code to simplify future FE analyses. In view of possible changes to shape and structure during the conceptual design activities, a parametric design approach allows incorporating modifications to the model efficiently.

Development of a master model concept for DEMO vacuum vessel

Energy Technology Data Exchange (ETDEWEB)

Mozzillo, Rocco; Marzullo, Domenico; Tarallo, Andrea [CREATE, University of Naples Federico II, DII, P.le Tecchio 80, 80125, Naples (Italy); Bachmann, Christian [EUROfusion PMU, Boltzmannstraße 2, 85748 Garching (Germany); Di Gironimo, Giuseppe, E-mail: peppe.digironimo@gmail.com [CREATE, University of Naples Federico II, DII, P.le Tecchio 80, 80125, Naples (Italy)

2016-11-15

Highlights: • The present work concerns the development of a first master concept model for DEMO vacuum vessel. • A parametric-associative CAD master model concept of a DEMO VV sector has been developed in accordance with DEMO design guidelines. • A proper CAD design methodology has been implemented in view of the later FEM analyses based on “shell elements”. - Abstract: This paper describes the development of a master model concept of the DEMO vacuum vessel (VV) conducted within the framework of the EUROfusion Consortium. Starting from the VV space envelope defined in the DEMO baseline design 2014, the layout of the VV structure was preliminarily defined according to the design criteria provided in RCC-MRx. A surface modelling technique was adopted and efficiently linked to the finite element (FE) code to simplify future FE analyses. In view of possible changes to shape and structure during the conceptual design activities, a parametric design approach allows incorporating modifications to the model efficiently.

Manufacture, testing and assembly preparation of the JET vacuum vessel

International Nuclear Information System (INIS)

Arbez, J.; Baeumel, S.; Dean, J.R.; Duesling, G.; Froger, C.; Hemmerich, J.L.; Walravens, M.; Walter, K.; Winkel, T.

1983-01-01

To reach the target pressure of 10 -9 mbar, JET's double-walled Inconel vacuum vessel is being manufactured and assembled in clean conditions and with meticulous leak detection. Each octant (1/8 of the torus) is baked in an oven to 520 0 C and leak tested at 350 0 C to reveal leaks as small as 10 -9 mbar l/s, which are repaired. In service the vessel will be baked periodically to 500 0 C by CO 2 passing between its walls. The single-walled ports will be electrically heated. (author)

Design of vacuum vessel for Indian Test Facility (INTF) for 100 keV neutral beams

International Nuclear Information System (INIS)

Joshi, Jaydeep; Yadav, Ashish; Gangadharan, Roopesh; Prasad, Rambilas; Ulahannan, Shino; Rotti, Chandramouli; Bandyopadhyay, Mainak; Chakraborty, Arun

2015-01-01

Highlights: • Thickness calculation and optimization for the main shell, ducts, Dishends and top lid on the main shell. • Nozzle and flange design for the port openings. • Support structure design for the main shell and ducts. • FEA validation of the INTF vessel for operational, seismic and lifting condition. - Abstract: The Indian Test Facility (INTF) vacuum vessel is designed to install a full-scale test set-up of Diagnostic Neutral Beam (DNB) [1] for the qualification of beam parameters and the behavior of beam-line components prior to installation and operation in ITER. Vacuum vessel is designed in cylindrical shape having length of ∼9 m with diameter of ∼4.5 m and has a detachable top-lid for mounting as well as removal of internal components during installation and maintenance phases. The Vessel has hemispherical dish-ends with large openings for high-voltage bushing on one side and duct on another side. Vessel is provided with openings for hydraulic, cryo, gas-feed and diagnostics. Vessel duct is composed of three segments with length ranges from 3 m to 5 m with diameter of ∼1.5 m and one vessel at the end to house the second calorimeter. The objective of this paper is to present the design and analysis of vacuum vessel, with respect to its functional and operational requirements. The design calculations are done as per ASME-BPVC SectionVIII-Div.1 and subsequently Finite Element Analysis (FEM) method has been adopted to verify the design.

Design of vacuum vessel for Indian Test Facility (INTF) for 100 keV neutral beams

Energy Technology Data Exchange (ETDEWEB)

Joshi, Jaydeep, E-mail: Jaydeep.joshi@iter-india.org [ITER-India, Institute for Plasma Research, A29, GIDC Electronics Estate, Gandhinagar 382016, Gujarat (India); Yadav, Ashish; Gangadharan, Roopesh [ITER-India, Institute for Plasma Research, A29, GIDC Electronics Estate, Gandhinagar 382016, Gujarat (India); Prasad, Rambilas [Madan Mohan Malaviya University of Technology, Gorakhpur, Uttar Pradesh 273001 (India); Ulahannan, Shino [Airframe Aerodesigns Pvt. Ltd., HAL Airport Exit Road, Old Airport Road, Bengaluru 17 (India); Rotti, Chandramouli; Bandyopadhyay, Mainak; Chakraborty, Arun [ITER-India, Institute for Plasma Research, A29, GIDC Electronics Estate, Gandhinagar 382016, Gujarat (India)

2015-10-15

Highlights: • Thickness calculation and optimization for the main shell, ducts, Dishends and top lid on the main shell. • Nozzle and flange design for the port openings. • Support structure design for the main shell and ducts. • FEA validation of the INTF vessel for operational, seismic and lifting condition. - Abstract: The Indian Test Facility (INTF) vacuum vessel is designed to install a full-scale test set-up of Diagnostic Neutral Beam (DNB) [1] for the qualification of beam parameters and the behavior of beam-line components prior to installation and operation in ITER. Vacuum vessel is designed in cylindrical shape having length of ∼9 m with diameter of ∼4.5 m and has a detachable top-lid for mounting as well as removal of internal components during installation and maintenance phases. The Vessel has hemispherical dish-ends with large openings for high-voltage bushing on one side and duct on another side. Vessel is provided with openings for hydraulic, cryo, gas-feed and diagnostics. Vessel duct is composed of three segments with length ranges from 3 m to 5 m with diameter of ∼1.5 m and one vessel at the end to house the second calorimeter. The objective of this paper is to present the design and analysis of vacuum vessel, with respect to its functional and operational requirements. The design calculations are done as per ASME-BPVC SectionVIII-Div.1 and subsequently Finite Element Analysis (FEM) method has been adopted to verify the design.

ITER vacuum vessel design (D201 subtask 1.3 and subtask 3). Final report

International Nuclear Information System (INIS)

1996-01-01

ITER Task No. D201, Vacuum Vessel Design (Subtask 1.3 and Subtask 3), was initiated to propose and evaluate local vacuum vessel reinforcement alternatives in proximity to the Neutral Beam, Radial Mid-Plane, Top, and Divertor Ports. These areas were reported to be highly stressed regions based on the results of preliminary stress analyses performed by the USHT (US Home Team) and the ITER Joint Central Team (JCT) at the Garching JWS (Joint Work Site). Initial design activities focused on the divertor port region which was reported to experience the highest stress intensities. Existing stress analysis models and results were reviewed with the USHT stress analysts to obtain an overall understanding of the vessel response to the various applied loads. These reviews indicated that the reported stress intensities in the divertor port region were significantly affected by the loads applied to the vessel in adjacent regions

Assessing the feasibility of a high-temperature, helium-cooled vacuum vessel and first wall for the Vulcan tokamak conceptual design

International Nuclear Information System (INIS)

Barnard, H.S.; Hartwig, Z.S.; Olynyk, G.M.; Payne, J.E.

2012-01-01

The Vulcan conceptual design (R = 1.2 m, a = 0.3 m, B 0 = 7 T), a compact, steady-state tokamak for plasma–material interaction (PMI) science, must incorporate a vacuum vessel capable of operating at 1000 K in order to replicate the temperature-dependent physical chemistry that will govern PMI in a reactor. In addition, the Vulcan divertor must be capable of handling steady-state heat fluxes up to 10 MW m −2 so that integrated materials testing can be performed under reactor-relevant conditions. A conceptual design scoping study has been performed to assess the challenges involved in achieving such a configuration. The Vulcan vacuum system comprises an inner, primary vacuum vessel that is thermally and mechanically isolated from the outer, secondary vacuum vessel by a 10 cm vacuum gap. The thermal isolation minimizes heat conduction between the high-temperature helium-cooled primary vessel and the water-cooled secondary vessel. The mechanical isolation allows for thermal expansion and enables vertical removal of the primary vessel for maintenance or replacement. Access to the primary vessel for diagnostics, lower hybrid waveguides, and helium coolant is achieved through ∼1 m long intra-vessel pipes to minimize temperature gradients and is shown to be commensurate with the available port space in Vulcan. The isolated primary vacuum vessel is shown to be mechanically feasible and robust to plasma disruptions with analytic calculations and finite element analyses. Heat removal in the first wall and divertor, coupled with the ability to perform in situ maintenance and replacement of divertor components for scientific purposes, is achieved by combining existing helium-cooled techniques with innovative mechanical attachments of plasma facing components, either in plate-type helium-cooled modules or independently bolted, helium-jet impingement-cooled tiles. The vacuum vessel and first wall design enables a wide range of potential PFC materials and configurations to

ITER vacuum vessel, in vessel components and plasma facing materials

International Nuclear Information System (INIS)

Ioki, Kimihiro; Enoeda, M.; Federici, G.

2007-01-01

Design of the NB ports including duct liners under heat loads of the neutral beams has been developed. Design of the in-wall shielding has been developed in more details considering the supporting structure and the assembly method. The ferromagnetic inserts have previously not been installed in the outboard midplane region due to irregularity caused by the tangential ports for NB injection. Due to this configuration, the maximum ripple is relatively large (∝1 %) in a limited region of the plasma and the toroidal field flux lines fluctuate ∝10 mm in the FW region. To avoid these problems, additional ferromagnetic inserts are to be installed in the equatorial port region. Detailed studies were carried out on the ITER vacuum vessel to define appropriate codes and standards in the context of the ITER licensing in France. A set of draft documents regarding the ITER vacuum vessel structural code were prepared including an RCC-MR Addendum for the ITER VV with justified exceptions or modifications. The main deviation from the base Code is the extensive use of UT in lieu of radiography for the volumetric examination of all one-side access welds of the outer shell and field joint. The procurement allocation of blanket modules among 6 parties was fixed and the blanket module design has progressed in cooperation with parties. Fabrication of mock-ups for prequalification testing is under way and the tests will be performed in 2007-2008. Development of new beryllium materials is progressing in China and Russia. The ITER limiters will be installed in equatorial ports at two toroidal locations. The limiter plasma-facing surface protrudes ∝8 cm from the FW during the start-up and shutdown phase. In the new limiter concept, the limiters are retracted by ∝8 cm during the plasma flat top phase. This concept gives important advantages; (i) mitigation of the particle and heat loads due to disruptions, ELMs and blobs, (ii) improvement of the power coupling with the ICRH antenna

Development of remote welding equipment and techniques for the TFTR vacuum vessel

International Nuclear Information System (INIS)

Masson, L.S.; Watts, K.D.; Larson, R.A.; Aldrich, W.C.

1980-01-01

In the event that the TFTR vacuum vessel is damaged or one of the toroidal field coils fails after the system has become substantially activated, it is necessary to remotely remove and replace the damaged section of the vessel using remote handling procedures. This paper describes a welding system developed through the final design stage to perform the remote welding necessary during the replacement operation. Information is presented describing the vessel configuration, the replacement sequence, the welding system requirements, welder configuration, supporting systems, the weld development program and future development requirements

Simulation of VDE under intervention of vertical stability control and vertical electromagnetic force on the ITER vacuum vessel

International Nuclear Information System (INIS)

Miyamoto, S.; Sugihara, M.; Shinya, K.; Nakamura, Y.; Toshimitsu, S.; Lukash, V.E.; Khayrutdinov, R.R.; Sugie, T.; Kusama, Y.; Yoshino, R.

2012-01-01

Highlights: ► Taking account of intervention of VS control, VDE simulations were carried out. ► Malfunctioning of VS circuit (positive feedback) enhances the vertical force. ► The worst case was explored for vertical force on the ITER vacuum vessel. ► We confirmed the force is still within the design margin even if the worst case. - Abstract: Vertical displacement events (VDEs) and disruptions usually take place under intervention of vertical stability (VS) control and the vertical electromagnetic force induced on vacuum vessels is potentially influenced. This paper presents assessment of the force that arises from the VS control in ITER VDEs using a numerical simulation code DINA. The focus is on a possible malfunctioning of the ex-vessel VS control circuit: radial magnetic field is unintentionally applied to the direction of enhancing the vertical displacement further. Since this type of failure usually causes the largest forces (or halo currents) observed in the present experiments, this situation must be properly accommodated in the design of the ITER vacuum vessel. DINA analysis shows that although the ex-vessel VS control modifies radial field, it does not affect plasma motion and current quench behavior including halo current generation because the vacuum vessel shields the field created by the ex-vessel coils. Nevertheless, the VS control modifies the force on the vessel by directly acting on the eddy current carried by the conducting structures of the vessel. Although the worst case was explored in a range of plasma inductance and pattern of VS control in combination with the in-vessel VS control circuit, the result confirmed that the force is still within the design margin.

Lubricant coating of dowel for the ITER vacuum vessel gravity support

Energy Technology Data Exchange (ETDEWEB)

Kim, B.Y. [ITER Korea, National Fusion Research Institute, Daejeon 305-333 (Korea, Republic of); Ahn, H.J., E-mail: hjahn@nfri.re.kr [ITER Korea, National Fusion Research Institute, Daejeon 305-333 (Korea, Republic of); Bak, J.S. [ITER Korea, National Fusion Research Institute, Daejeon 305-333 (Korea, Republic of); Choi, C.H.; Ioki, K. [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul Lez Durance (France); Zauner, C. [KRP-Mechatec Engineering GbR, 85748 Garching b, Muenchen (Germany)

2012-08-15

The ITER vacuum vessel gravity supports located in the lower level shall sustain loads in radial, toroidal and vertical directions. The hinge type VVGS consists of two hinges, upper and lower blocks and dowels. In order to develop the design concept and verify the structural integrity of the hinge system, the design analysis has been performed in detail. Inclination of 15 Degree-Sign for the hinge based supporting system was introduced to provide centering force to make stable equilibrium state of the vacuum vessel. Due to this inclination the hinges are rotated by the radial expansion of the VV during operation and baking, respectively. If a dowel is seized in the hinge, the supporting system can be highly stressed due to the restrained displacement in the seized dowel. Therefore, solid lubricant coatings were suggested on dowels in order to avoid seizing in the sliding area. In this work, several sets of coupons were made with different coating materials to investigate the effect according to the selection of coating material. Also, a test facility was designed to cover the ITER relevant loading and boundary conditions, e.g. vacuum condition, temperature, contact pressure, cycles, etc. From those test results, the optimized coating method was found to avoid seizure of dowel in the ITER VVGS.

Materials requirements for the ITER vacuum vessel and in-vessel components - approaching the construction phase

International Nuclear Information System (INIS)

Barabash, V.; Ioki, K.; Pick, M.; Girard, J.P.; Merola, M.

2007-01-01

Full text of publication follows: The ITER activities are fully devoted toward its construction. In accordance with the ITER integrated project schedule, the procurement specifications for the manufacturing of the Vacuum Vessel should be prepared by March 2008 and the procurement specifications for the in-vessel components (first wall/blanket, divertor) by 2009. To update the design, considering design and technology evolution, the ITER Design Review has been launched. Among the various topics being discussed are the important issues related to selection of materials, material procurement, and assessment of performance during operation. The main requirements related to materials for the vacuum vessel and the in-vessel components are summarized in the paper. The specific licensing requirements are to be followed for structural materials of pressure and nuclear pressure equipment components for construction of ITER. In addition, the procurements in ITER will be done mostly 'in-kind' and it is assumed that materials for these components will be produced by different Parties. However, in accordance with the regulatory requirements and quality requirements for operation, common specifications and the general rules to fulfill these requirements are to be adopted. For some ITER components (e.g. first wall, divertor high heat flux components), the ultimate qualification of the joining technologies (Be/Cu, SS/Cu, CFC/Cu, W/Cu) is under final evaluation. Successful accomplishment of the qualification program will allow to proceed with procurements of the components for ITER. The criteria for acceptance of these components and materials after manufacturing are described and the main results will be reported. Additional materials issues, which come from the on-going manufacturing R and D program, will be also described. Finally, further materials activity during the construction phase, needs for final qualification and acceptance of materials are discussed. (authors)

Studies on structural analysis related to the design of the JT-60 vacuum vessel

International Nuclear Information System (INIS)

Takatsu, Hideyuki

1987-06-01

Studies on structural analysis of a vacuum vessel of tokamak-type fusion devices are presented. The present studies are proposals for the structural analysis procedures of the tokamak-type fusion devices and are composed of five parts, each of which covers the fundamental area required for the structural analysis and design; stress analysis, dynamic response analysis, fatigue evaluation, buckling analysis and seismic analysis. Special attention is paid to the critical component, bellows and the critical load, electromagnetic forces. A new finite element method modeling technique is proposed for the stress analysis of U-shaped bellows, where the bellows is replaced by an orthotropic plate having the same stiffness as the bellows. The applicability of the present modeling technique is confirmed by verification tests. Dynamic response and fatigue of the vacuum vessel are critical issues of the structural analysis and design of the tokamak-type fusion devices. Detailed dynamic response analyses of the JT-60 vacuum vessel are presented paying special attention to the dynamic behavior of the U-shaped bellows, where the above-mentioned modeling technique of the U-shaped bellows is applied. A fatigue evaluation method of the vacuum vessel under the dynamic electromagnetic forces is proposed, which utilizes the results of the detailed dynamic response analysis. In the present method, fatigue evaluation method for random loads is applied. Torsional fatigue strength of the welded bellows is experimentally evaluated aiming the application to the port of the fusion device and it is shown that the welded bellows reveals elastic buckling and spiral distortion under a small angle of tortion. Two formulae are proposed to evaluate the stress of the welded bellows under the forced angle of tortion. (author)

The design study of the JT-60SU device. No. 4. The vacuum vessel and cryostat of JT-60SU

International Nuclear Information System (INIS)

Neyatani, Yuzuru; Ushigusa, Kenkichi; Tobita, Kenji

1997-03-01

The vacuum vessel and the cryostat for the JT-60 Super Upgrade (JT-60SU) have been designed. Two types of the complex materials for the vacuum vessel were chosen on the basis of the avoidance of tritium occlusion and the low irradiation, i.e. (1) SUS316 covered by tungsten plate (30mm thickness) as a γ-ray shielding, (2) Ti-6Al-4V alloy covered by SUS430 plate (1mm thickness) as a tritium protector. Selecting the double skin type of vacuum vessel with toroidally continued structure gave the basic design of the vacuum vessel satisfying the design criteria of the vessel strength for the electromagnetic force, heat load and the property of radiation shielding. The characteristics of the SUS316 covered by tungsten plate type is that as the tungsten can shield the γ-ray, the dose rate inside the vacuum vessel during the maintenance can reduce effectively. The advantage of the Ti-6Al-4V alloy covered by SUS430 plate type vacuum vessel is the quick reduction of the radioactive isotope because of no production of the isotopes with long half-life periods. Channel type and vertical type of the divertor were designed. The sector type of toroidally separated structure was selected for the remote handling. The material of the armor plate was not determined because no material endure the high heat load on the divertor. The cryostat composing the dome and the tank was designed. The electromagnetic force by the eddy current, generated at the plasma start up phase and at the quench of CS super-conducting coil, were small compared to the force produced by the stress limit. (author)

Modeling the Thermal Mechanical Behavior of a 300 K Vacuum Vessel that is Cooled by Liquid Hydrogen in Film Boiling

International Nuclear Information System (INIS)

Yang, S.Q.; Green, M.A.; Lau, W.

2004-01-01

This report discusses the results from the rupture of a thin window that is part of a 20-liter liquid hydrogen vessel. This rupture will spill liquid hydrogen onto the walls and bottom of a 300 K cylindrical vacuum vessel. The spilled hydrogen goes into film boiling, which removes the thermal energy from the vacuum vessel wall. This report analyzes the transient heat transfer in the vessel and calculates the thermal deflection and stress that will result from the boiling liquid in contact with the vessel walls. This analysis was applied to aluminum and stainless steel vessels

ITER vacuum vessel fabrication plan and cost study (D 68) for the international thermonuclear experimental reactor

International Nuclear Information System (INIS)

1995-01-01

ITER Task No. 8, Vacuum Vessel Fabrication Plan and Cost Study (D68), was initiated to assess ITER vacuum vessel fabrication, assembly, and cost. The industrial team of Raytheon Engineers ampersand Constructors and Chicago Bridge ampersand Iron (Raytheon/CB ampersand I) reviewed the current vessel basis and prepared a manufacturing plan, assembly plan, and cost estimate commensurate with the present design. The guidance for the Raytheon/CB ampersand I assessment activities was prepared by the ITER Garching Work Site. This guidance provided in the form of work descriptions, sketches, drawings, and costing guidelines for each of the presently identified vacuum vessel Work Breakdown Structure (WBS) elements was compiled in ITER Garching Joint Work Site Memo (Draft No. 9 - G 15 MD 01 94-17-05 W 1). A copy of this document is provided as Appendix 1 to this report. Additional information and clarifications required for the Raytheon/CB ampersand I assessments were coordinated through the US Home Team (USHT) and its technical representative. Design details considered essential to the Task 8 assessments but not available from the ITER Joint Central Team (JCT) were generated by Raytheon/CB ampersand I and documented accordingly

Baking of the vacuum vessel prototype of the Spanish stellarator with a control system based on neural network

International Nuclear Information System (INIS)

Botija, J.; Alonso, J.; Blaumoser, M.

1995-01-01

To bake uniformly, up to 150 C, the vacuum vessel of the Spanish Stellarator TJ-II represents a difficult task to be demonstrated. In order to study the temperature distribution in the vessel, a prototype of this vacuum vessel, mounted in a stainless steel structure, has been heated by means of electrical panels and eddy currents. The induction heating system is provided applying 498 A/11.7 V at 50 Hz to the toroidal field coil located in the middle of the vessel prototype. Practically, this system only heats adequately the rings and poorly the so called groove of the vacuum vessel. On the contrary, the electrical heaters, with a power density of 0.5 W/cm 2 , heat the external part of the sectors and ports. The high density of temperature sensors ensures the uniformity of the heating process during the long heating cycles, making advisable a fault-tolerant control system based on Artificial Neural Networks (ANNs) that implements the control loop to regulate and protect both heating systems. This paper deals with the results of this experiment

An Approach for Selection of Flow Regime and Models for Conservative Evaluation of a Vessel Integrity Monitoring System for Water-Cooled Vacuum Vessels

International Nuclear Information System (INIS)

Pointer, W. David; Ruggles, Arthur E.

2003-01-01

Thin-walled vacuum containment vessels cooled by circulating water jackets are often utilized in research and industrial applications where isolation of equipment or experiments from the influences of the surrounding environment is desirable. The development of leaks in these vessels can result in costly downtime for the facility. A Vessel Integrity Monitoring System (VIMS) is developed to detect leak formation and estimate the size of the leak to allow evaluation of the risk associated with continued operation. A wide range of leak configurations and fluid flow phenomena are considered in the evaluation of the rate at which a tracer gas dissolved in the cooling jacket water is transported into the vacuum vessel. A methodology is presented that uses basic fluid flow models and careful evaluation of their ranges of applicability to provide a conservative estimate of the transport rates for the tracer gas and hence the time required for the VIMS to detect a leak of a given size

Baking system for ports of experimental advanced super-conducting tokamak vacuum vessel and thermal stress analysis

International Nuclear Information System (INIS)

Cheng Yali; Bao Liman; Song Yuntao; Yao Damao

2006-01-01

The baking system of Experimental Advanced Super-Conducting Toakamk (EAST) vacuum vessel is necessary to obtain the baking temperature of 150 degree C. In order to define suitable alloy heaters and achieve their reasonable layouts, thermal analysis was carried out with ANSYS code. The analysis results indicate that the temperature distribution and thermal stress of most parts of EAST vacuum vessel ports are uniform, satisfied for the requirement, and are safe based on ASME criterion. Feasible idea on reducing the stress focus is also considered. (authors)

ATF data management

International Nuclear Information System (INIS)

Kannan, K.L.; Baylor, L.R.

1988-01-01

Data management for the Advanced Toroidal Facility (ATF), a stellarator located at Oak Ridge National Laboratory, is provided by DMG, a locally developed, VAX-based software system. DMG is a data storage and retrieval software system that provides the user interface to ATF raw and analyzed data. Data are described in terms of data models and data types and are organized as signals into files, which are internally documented. The system was designed with user accessibility, software maintainability, and extensibility as primary goals. Extensibility features include compatibility with ATF as it moves from pulsed to steady-state operation and capability for use of the DMG system with experiments other than ATF. DMG is implemented as a run-time library of routines available as a shareable image. General-purpose and specialized data acquisition and analysis applications have been developed using the DMG system. This article describes the DMG system and the interfaces to it

Magnetic and electrical properties of ITER vacuum vessel steels

International Nuclear Information System (INIS)

Mergia, K.; Apostolopoulos, G.; Gjoka, M.; Niarchos, D.

2007-01-01

Full text of publication follows: Ferritic steel AISI 430 is a candidate material for the lTER vacuum vessel which will be used to limit the ripple in the toroidal magnetic field. The magnetic and electrical properties and their temperature dependence in the temperature range 300 - 900 K of AISI 430 ferritic stainless steels are presented. The temperature variation of the coercive field, remanence and saturation magnetization as well as electrical resistivity and the effect of annealing on these properties is discussed. (authors)

Pulse discharge cleaning of the vacuum vessel of HL-1 tokamak

International Nuclear Information System (INIS)

Li Guodong; Zhu Yukun; Xiao Zhenggui; Sun Shouqi; Ze Mingrui

1986-01-01

The HL-1 Tokamak was test-operated on September 21, 1984. During the period of vacuum conditioning, including 60 hours of baking up to 200 deg C and 7 x 10 4 shots of pulse discharge cleaning, the calculated quantities of carbon and oxygen removed are equivalent to 24 and 6 monolayers, respectively. Then, 124 shots of tokamak discharge were performed with low level plasma parameters. The plasma current and pulse length achieved were 60 kA and 85 ms at the toroidal magnetic field of 15 kG. This paper described the techniques used and the effect on discharge characteristics of bakeout and pulse discharge cleaning of the vacuum vessel

Diagnostics carried by a light multipurpose deployer for vacuum vessel interventions

Energy Technology Data Exchange (ETDEWEB)

Houry, M., E-mail: Michael.houry@cea.fr [CEA-IRFM, F-13108 Saint-Paul-Lez-Durance (France); Gargiulo, L.; Balorin, C.; Bruno, V.; Keller, D.; Roche, H. [CEA-IRFM, F-13108 Saint-Paul-Lez-Durance (France); Kammerer, N.; Measson, Y. [CEA, LIST, F-92265 Fontenay-aux-Roses (France); Carrel, F.; Schoepff, V. [CEA, LIST, F-91191 Gif-sur-Yvette (France)

2011-10-15

ITER will greatly rely on remote-handling operations to accomplish its scientific missions. Robotic systems will also be required to operate inside vacuum vessels in order to limit or replace human access, to intervene quickly between experimental sessions for in-vessel inspections and measurements, and to preserve the machine conditioning and thus improve machine availability. In this prospect, a multipurpose carrier prototype called Articulated Inspection Arm (AIA) was developed by CEA laboratories within the European work program. With an embedded camera, it successfully demonstrated close inspection feasibility inside Tore Supra tokamak. The AIA robot was designed for mini-invasive operations with interchangeable diagnostics to be plugged at its head. This covers various applications for the safety, the operation and the scientific mission (in-vessel inspection, plasma diagnostics calibrations or inner components analysis and treatments). This paper presents recent analysis and results obtain with diagnostics developed by CEA for in-vessel remote-handling intervention.

Diagnostics carried by a light multipurpose deployer for vacuum vessel interventions

International Nuclear Information System (INIS)

Houry, M.; Gargiulo, L.; Balorin, C.; Bruno, V.; Keller, D.; Roche, H.; Kammerer, N.; Measson, Y.; Carrel, F.; Schoepff, V.

2011-01-01

ITER will greatly rely on remote-handling operations to accomplish its scientific missions. Robotic systems will also be required to operate inside vacuum vessels in order to limit or replace human access, to intervene quickly between experimental sessions for in-vessel inspections and measurements, and to preserve the machine conditioning and thus improve machine availability. In this prospect, a multipurpose carrier prototype called Articulated Inspection Arm (AIA) was developed by CEA laboratories within the European work program. With an embedded camera, it successfully demonstrated close inspection feasibility inside Tore Supra tokamak. The AIA robot was designed for mini-invasive operations with interchangeable diagnostics to be plugged at its head. This covers various applications for the safety, the operation and the scientific mission (in-vessel inspection, plasma diagnostics calibrations or inner components analysis and treatments). This paper presents recent analysis and results obtain with diagnostics developed by CEA for in-vessel remote-handling intervention.

Analysis list: Atf4 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Atf4 Blood,Embryonic fibroblast,Epidermis + mm9 http://dbarchive.biosciencedbc.jp/k...yushu-u/mm9/target/Atf4.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Atf4.5.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/mm9/target/Atf4.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Atf...4.Blood.tsv,http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Atf4.Embryonic_fi...broblast.tsv,http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Atf4.Epidermis.tsv http://dbarchive.bioscience

Stress analysis of a double-wall vacuum vessel for ITER

International Nuclear Information System (INIS)

Conner, D.L.; Williamson, D.E.; Nelson, B.E.

1991-01-01

The preliminary structural analyses performed in support of the design of the vacuum vessel for the International Thermonuclear Experimental Reactor (ITER) are described. A thin, double-wall, all-welded structure is the proposed design concept analyzed. The results of the static stress analysis indicate the adequacy of such a structure. The effects of the proposed high-aspect-ratio design configuration on loading and stresses are also discussed. 4 refs., 6 figs., 1 tab

ATF2 Proposal v. 2

CERN Document Server

Grishanov, B I; Alabau-Pons, M; Angal-Kalinin, Deepa; Appleby, R; Araki, S; Bailey, I; Bambade, P; Bane, Karl Leopold Freitag; Barlow, R; Blair, G A; Bolzon, B; Boorman, G; Bosco, A; Brachmann, A; Braun, Hans Heinrich; Burrows, P N; Carter, J; Choi, J; Christian, Glenn B; Clarke, C; Dabiri-Khah, A; Dadoun, O; Danagulyan, S; Delerue, N; Dixit, S; Driouichi, C; Elsen E; Gao, J; Geffroy, N; Gronberg, J; Hartin, Anthony F; Hayano, H; Higashi, Y; Himel, T; Honda, Y; Howell, D; Huang, J Y; Iwashita, Y; Jenner, L; Jones, J; Jones, R; Jérémie, A; Kalinin, A; Kanazawa, K; Kang, H S; Karyotakis, Yu; Kim, E S; Kim, S; Komamiya, S; Kourevlev, German Yu; Kubo, K; Kumada, M; Kume, T; Kuriki, M; Kuroda, S; Liu, W; Logatchev, P V; Lyapin, A; Malton, S; Markiewicz, T W; Masuzawa, M; Mihara, T; Miller, D J; Molloy, S; Mtingwa, S; Naito, T; Nan-Phinney, Y; Napoly, O; Nelson, J; Okugi, T; Payet, J; Pei, G X; Pivi, M T F; Podgorny, F; Price, M; Raubenheimer, T O; Reichold, A; Ross, M; Sanuki, T; Schulte, Daniel; Seryi, R A; Solyak, N; Soo Ko In; Spencer, C M; Suehara, T; Sugahara, R; Takahashi, T; Takashi-Boogert, S; Tauchi, T; Telnov, Valery I; Tenenbaum, P G; Terunuma, N; Toge, N; Torrence, E; Urakawa, J; Urner, D; Vogel, V; Walker, N; Wang, J Q; Wendt, M; White, G; Wing, M; Wolski, A; Woodley, M; Yamaoka, H; Yokoya, K; Zimmermann, Frank

2006-01-01

For achieving the high luminosity required at the International Linear Collider (ILC), it is critical to focus the beams to nanometer size with the ILC Beam Delivery System (BDS), and to maintain the beam collision with a nanometer-scale stability. To establish the technologies associated with this ultra-high precision beam handling, it has been proposed to implement an ILC-like final focus optics in an extension of the existing extraction beamline of ATF at KEK. The ATF is considered to be the best platform for this exercise, since it provides an adequate ultra-low emittance electron beam in a manner dedicated to the development of ILC. The two major goals for this facility, called ATF2, are : (A) Achievement of a 37 nm beam size, and (B) control of beam position down to 2 nm level. The scientific justification for the ATF2 project and its technical design have been described in Volume 1 of the ATF2 Proposal [1]. We present here Volume 2 of the ATF2 Proposal, in which we present specifics of the construction...

Mechanical strength evaluation of the welded bellows for the ports of the JT-60 vacuum vessel

International Nuclear Information System (INIS)

Takatso, H.; Shimizu, M.; Yamamoto, M.

1983-01-01

Mechanical strength of the welded bellows for the ports of the JT-60 vacuum vessel was evaluated, laying the emphasis on the fatigue strength under the torsional electromagnetic force. The welded bellows were designed to be loaded with the forced deflection due to the relative displacement between the vacuum vessel and the external fixed point, the atmospheric pressure and the forced torsional angle due to the electromagnetic force. Stresses caused by the former two were estimated following the formulae proposed by the Kellogg Company. On the other hand, two formulae were established to estimate the stress caused by the last, after examining experimentally the behavior of the welded bellows under the torsional load; one is the shearing stress evaluation formula and the other is the axial bending stress evaluation formula. It was found that the welded bellows can easily buckle under the torsional load and the former formula corresponds to the case of non-buckling and the latter to the case of buckling. The present mechanical strength evaluation method was applied to the three kinds of the welded bellows to be used in the ports of the JT-60 vacuum vessel (neutral beam injection ports, vacuum pumping ports and the adjustable limiter ports) and it was confirmed that they have sufficient strength in the range of the design load conditions

Analysis list: Atf3 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Atf3 Blood,Pancreas + mm9 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Atf3.1.tsv http:...//dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Atf3.5.tsv http://dbarchive.biosciencedbc.jp/k...yushu-u/mm9/target/Atf3.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Atf3.Blood.tsv,http://dba...rchive.biosciencedbc.jp/kyushu-u/mm9/colo/Atf3.Pancreas.tsv http://dbarchive.bios...ciencedbc.jp/kyushu-u/mm9/colo/Blood.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Pancreas.gml ...

Analysis list: ATF4 [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available ATF4 Blood,Others + hg19 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/target/ATF...4.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/target/ATF4.5.tsv http://dbarchive.biosciencedbc.jp/...kyushu-u/hg19/target/ATF4.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/colo/ATF4.Blood.tsv,http://dbarchive.bioscience...dbc.jp/kyushu-u/hg19/colo/ATF4.Others.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/hg19/colo/Blood.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/colo/Others.gml ...

Manufacturing device for vacuum vessel of thermonuclear reactor and manufacturing method therefor

International Nuclear Information System (INIS)

Yanagi, Hiroshi; Shibui, Masanao; Uchida, Takaho

1998-01-01

The present invention provides a method of manufacturing a vacuum vessel of a thermonuclear reactor with no welding deformation. Namely, there are disposed a manufacturing device comprises a welding machine equipped with a plurality of welding torches which can conduct synchronizing welding and a torch positioning mechanism for positioning the plurality of welding torches each at an optional distance. Then, both ends of a splice plate can be welded by the plurality of welding torches under synchronization. Accordingly, joining portions of sectors of a vacuum vessel can be welded in the site with no deviation of beveling at joining portions between an outer wall and an inner wall with the splice plate due to welding deformation. In addition, the welding machine is mounted on a travelling type clamping mechanism stand or a travelling type clamping mechanism. With such a constitution, since the peripheries of the joining portions on the inner wall are clamped with each other by the travelling type clamping mechanism, no angular distortion is caused in any welded portion of the outer wall. (I.S.)

Structural analysis of the ITER vacuum vessel

Energy Technology Data Exchange (ETDEWEB)

Sannazzaro, G.; Ioki, K.; Johnson, G.; Onozuka, M.; Utin, Y. [ITER Joint Work Site, Garching (Germany); Nelson, B. [Oak Ridge National Lab., TN (United States); Swanson, J. [USHT, Raytheon, Princeton (United States)

1998-07-01

The ITER Vacuum Vessel (VV) must withstand a large number of loading conditions including electromagnetic, seismic, operational and upset pressure, thermal and test loads. All of the loading conditions and load combinations have been categorized and classified to permit the allowable stress to be defined in accordance with the recommendations of the ASME code. The most severe loading conditions for the VV are the toroidal field coil fast discharge (TFCFD) and the load combination of seismic and electromagnetic loads due to a plasma vertical instability. The areas of high stress are the regions around the VV and the blanket supports, and the attachment of the ports to the main shell. In all of the loading conditions and load combinations the calculated stresses are below the allowable values. (authors)

Vacuum Technology

Energy Technology Data Exchange (ETDEWEB)

Biltoft, P J

2004-10-15

The environmental condition called vacuum is created any time the pressure of a gas is reduced compared to atmospheric pressure. On earth we typically create a vacuum by connecting a pump capable of moving gas to a relatively leak free vessel. Through operation of the gas pump the number of gas molecules per unit volume is decreased within the vessel. As soon as one creates a vacuum natural forces (in this case entropy) work to restore equilibrium pressure; the practical effect of this is that gas molecules attempt to enter the evacuated space by any means possible. It is useful to think of vacuum in terms of a gas at a pressure below atmospheric pressure. In even the best vacuum vessels ever created there are approximately 3,500,000 molecules of gas per cubic meter of volume remaining inside the vessel. The lowest pressure environment known is in interstellar space where there are approximately four molecules of gas per cubic meter. Researchers are currently developing vacuum technology components (pumps, gauges, valves, etc.) using micro electro mechanical systems (MEMS) technology. Miniature vacuum components and systems will open the possibility for significant savings in energy cost and will open the doors to advances in electronics, manufacturing and semiconductor fabrication. In conclusion, an understanding of the basic principles of vacuum technology as presented in this summary is essential for the successful execution of all projects that involve vacuum technology. Using the principles described above, a practitioner of vacuum technology can design a vacuum system that will achieve the project requirements.

Hydrogen/hydrocarbon explosions in the ITER vacuum vessel

International Nuclear Information System (INIS)

Goranson, P.L.

1992-01-01

The consequences of H 2 /hydrocarbon detonations in the vacuum vessel (torus) of the International Thermonuclear Experimental Reactor (ITER) have been studied. The most likely scenario for such a detonation involves a water leak into the torus and a vent of the torus to atmosphere, permitting the formation of an explosive fuel-air mixture. The generation of fuel gases and possible sources of air or oxygen are reviewed, and the severity and effects of specific fuel-air mixture explosions are evaluated. Detonation or deflagration of an explosive mixture could result in pressures exceeding the maximum allowable torus pressure. Further studies to examine the design details and develop an event-tree study of events following a gas detonation are recommended

Kinematic and dynamic analysis of a serial-link robot for inspection process in EAST vacuum vessel

Energy Technology Data Exchange (ETDEWEB)

Peng Xuebing, E-mail: pengxb@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Sciences, P.O. Box 1126, Shushanhu Road 350, Hefei, Anhui 230031 (China); Yuan Jianjun; Zhang Weijun [Research Institute of Robotics, Mechanical Engineering School, Shanghai Jiao Tong University, No.800, Dong Chuan Road, Min Hang District, Shanghai 200240 (China); Yang Yang; Song Yuntao [Institute of Plasma Physics, Chinese Academy of Sciences, P.O. Box 1126, Shushanhu Road 350, Hefei, Anhui 230031 (China)

2012-08-15

Highlights: Black-Right-Pointing-Pointer A serial-link robot FIVIR is proposed for inspection of EAST PFCs between plasma shots. Black-Right-Pointing-Pointer The FIVIR is a function modular design and has specially designed curvilinear mechanism for axes 4-6. Black-Right-Pointing-Pointer The D-H coordinate systems, forward and inverse kinematic model can be easily established and solved for the FIVIR. Black-Right-Pointing-Pointer The FIVIR can fulfill the required workspace and has a good dynamic performance in the inspection process. - Abstract: The present paper introduces a serial-link robot which is named flexible in-vessel inspection robot (FIVIR) and developed for Experimental Advanced Superconducting Tokamak (EAST). The task of the robot is to carry process tools, such as viewing camera and leakage detector, to inspect the components installed inside of EAST vacuum vessel. The FIVIR can help to understand the physical phenomena which could be happened in the vacuum vessel during plasma operation and could be one part of EAST remote handling system if needed. The FIVIR was designed with the consideration of having easy control and a good mechanics property which drives it resulted in function modular design. The workspace simulation and kinematic analysis are given in this paper. The dynamic behavior of the FIVIR is studied by multi-body system simulation using ADAMS software. The study result shows the FIVIR has ascendant kinematic and dynamic performance and can fulfill the design requirement for inspection process in EAST vacuum vessel.

Kinematic and dynamic analysis of a serial-link robot for inspection process in EAST vacuum vessel

International Nuclear Information System (INIS)

Peng Xuebing; Yuan Jianjun; Zhang Weijun; Yang Yang; Song Yuntao

2012-01-01

Highlights: ► A serial-link robot FIVIR is proposed for inspection of EAST PFCs between plasma shots. ► The FIVIR is a function modular design and has specially designed curvilinear mechanism for axes 4–6. ► The D-H coordinate systems, forward and inverse kinematic model can be easily established and solved for the FIVIR. ► The FIVIR can fulfill the required workspace and has a good dynamic performance in the inspection process. - Abstract: The present paper introduces a serial-link robot which is named flexible in-vessel inspection robot (FIVIR) and developed for Experimental Advanced Superconducting Tokamak (EAST). The task of the robot is to carry process tools, such as viewing camera and leakage detector, to inspect the components installed inside of EAST vacuum vessel. The FIVIR can help to understand the physical phenomena which could be happened in the vacuum vessel during plasma operation and could be one part of EAST remote handling system if needed. The FIVIR was designed with the consideration of having easy control and a good mechanics property which drives it resulted in function modular design. The workspace simulation and kinematic analysis are given in this paper. The dynamic behavior of the FIVIR is studied by multi-body system simulation using ADAMS software. The study result shows the FIVIR has ascendant kinematic and dynamic performance and can fulfill the design requirement for inspection process in EAST vacuum vessel.

Calculation of voltages and currents induced in the vacuum vessel of ASDEX by plasma disruptions

International Nuclear Information System (INIS)

Preis, H.

1978-01-01

An approximation method is used to analyze the electromagnetic diffusion process induced in the walls of the ASDEX vacuum vessel by plasma disruptions. For this purpose the rotational-symmetric vessel is regarded as N = 82 circular conductors connected in parallel and inductively coupled with one another and with the plasma. The transient currents and voltages occurring in this circuit are calculated with computer programs. From the calculated currents it is possible to determine the time behavior of the distributions of the current density and magnetic force density in the vessel walls. (orig.) [de

Design and material selection for ITER first wall/blanket, divertor and vacuum vessel

Science.gov (United States)

Ioki, K.; Barabash, V.; Cardella, A.; Elio, F.; Gohar, Y.; Janeschitz, G.; Johnson, G.; Kalinin, G.; Lousteau, D.; Onozuka, M.; Parker, R.; Sannazzaro, G.; Tivey, R.

1998-10-01

Design and R&D have progressed on the ITER vacuum vessel, shielding and breeding blankets, and the divertor. The principal materials have been selected and the fabrication methods selected for most of the components based on design and R&D results. The resulting design changes are discussed for each system.

ATF3 represses PPARγ expression and inhibits adipocyte differentiation

Energy Technology Data Exchange (ETDEWEB)

Jang, Min-Kyung; Jung, Myeong Ho, E-mail: jung0603@pusan.ac.kr

2014-11-07

Highlights: • ATF3 decrease the expression of PPARγ and its target gene in 3T3-L1 adipocytes. • ATF3 represses the promoter activity of PPARγ2 gene. • ATF/CRE (−1537/−1530) is critical for ATF3-mediated downregulation of PPARγ. • ATF3 binds to the promoter region containing the ATF/CRE. • ER stress inhibits adipocyte differentiation through downregulation of PPARγ by ATF3. - Abstract: Activating transcription factor 3 (ATF3) is a stress-adaptive transcription factor that mediates cellular stress response signaling. We previously reported that ATF3 represses CCAAT/enhancer binding protein α (C/EBPα) expression and inhibits 3T3-L1 adipocyte differentiation. In this study, we explored potential role of ATF3 in negatively regulating peroxisome proliferator activated receptor-γ (PPARγ). ATF3 decreased the expression of PPARγ and its target gene in 3T3-L1 adipocytes. ATF3 also repressed the activity of −2.6 Kb promoter of mouse PPARγ2. Overexpression of PPARγ significantly prevented the ATF3-mediated inhibition of 3T3-L1 differentiation. Transfection studies with 5′ deleted-reporters showed that ATF3 repressed the activity of −2037 bp promoter, whereas it did not affect the activity of −1458 bp promoter, suggesting that ATF3 responsive element is located between the −2037 and −1458. An electrophoretic mobility shift assay and chromatin immunoprecipitation assay demonstrated that ATF3 binds to ATF/CRE site (5′-TGACGTTT-3′) between −1537 and −1530. Mutation of the ATF/CRE site abrogated ATF3-mediated transrepression of the PPARγ2 promoter. Treatment with thapsigargin, endoplasmic reticulum (ER) stress inducer, increased ATF3 expression, whereas it decreased PPARγ expression. ATF3 knockdown significantly blocked the thapsigargin-mediated downregulation of PPARγ expression. Furthermore, overexpression of PPARγ prevented inhibition of 3T3-L1 differentiation by thapsigargin. Collectively, these results suggest that ATF3-mediated

Electromagnetic loads and structural response of the CIT [Compact Ignition Tokamak] vacuum vessel to plasma disruptions

International Nuclear Information System (INIS)

Salem, S.L.; Listvinsky, G.; Lee, M.Y.; Bailey, C.

1987-01-01

Studies of the electromagnetic loads produced by a variety of plasma disruptions, and the resulting structural effects on the compact Ignition Tokamak (CIT) vacuum vessel (VV), have been performed to help optimize the VV design. A series of stationary and moving plasmas, with disruption rates from 0.7--10.0 MA/ms, have been analyzed using the EMPRES code to compute eddy currents and electromagnetic pressures, and the NASTRAN code to evaluate the structural response of the vacuum vessel. Key factors contributing to the magnitude of EM forces and resulting stresses on the vessel have been found to include disruption rate, and direction and synchronization of plasma motion with the onset of plasma current decay. As a result of these analyses, a number of design changes have been made, and design margins for the present 1.75 meter design have been improved over the original CIT configuration. 1 ref., 10 figs., 4 tabs

Chondrocytic Atf4 regulates osteoblast differentiation and function via Ihh.

Science.gov (United States)

Wang, Weiguang; Lian, Na; Ma, Yun; Li, Lingzhen; Gallant, Richard C; Elefteriou, Florent; Yang, Xiangli

2012-02-01

Atf4 is a leucine zipper-containing transcription factor that activates osteocalcin (Ocn) in osteoblasts and indian hedgehog (Ihh) in chondrocytes. The relative contribution of Atf4 in chondrocytes and osteoblasts to the regulation of skeletal development and bone formation is poorly understood. Investigations of the Atf4(-/-);Col2a1-Atf4 mouse model, in which Atf4 is selectively overexpressed in chondrocytes in an Atf4-null background, demonstrate that chondrocyte-derived Atf4 regulates osteogenesis during development and bone remodeling postnatally. Atf4 overexpression in chondrocytes of the Atf4(-/-);Col2a1-Atf4 double mutants corrects the reduction in stature and limb in Atf4(-/-) embryos and rectifies the decrease in Ihh expression, Hh signaling, proliferation and accelerated hypertrophy that characterize the Atf4(-/-) developing growth plate cartilages. Unexpectedly, this genetic manipulation also restores the expression of osteoblastic marker genes, namely Ocn and bone sialoprotein, in Atf4(-/-) developing bones. In Atf4(-/-);Col2a1-Atf4 adult mice, all the defective bone parameters found in Atf4(-/-) mice, including bone volume, trabecular number and thickness, and bone formation rate, are rescued. In addition, the conditioned media of ex vivo cultures from wild-type or Atf4(-/-);Col2a1-Atf4, but not Atf4(-/-) cartilage, corrects the differentiation defects of Atf4(-/-) bone marrow stromal cells and Ihh-blocking antibody eliminates this effect. Together, these data indicate that Atf4 in chondrocytes is required for normal Ihh expression and for its paracrine effect on osteoblast differentiation. Therefore, the cell-autonomous role of Atf4 in chondrocytes dominates the role of Atf4 in osteoblasts during development for the control of early osteogenesis and skeletal growth.

Design and material selection for ITER first wall/blanket, divertor and vacuum vessel

Energy Technology Data Exchange (ETDEWEB)

Ioki, K.; Barabash, V.; Cardella, A.; Elio, F.; Gohar, Y.; Janeschitz, G.; Johnson, G.; Kalinin, G.; Lousteau, D.; Onozuka, M.; Parker, R.; Sannazzaro, G.; Tivey, R. [ITER JCT, Garching (Germany)

1998-10-01

Design and R and D have progressed on the ITER vacuum vessel, shielding and breeding blankets, and the divertor. The principal materials have been selected and the fabrication methods selected for most of the components based on design and R and D results. The resulting design changes are discussed for each system. (orig.) 11 refs.

Aluminium vacuum vessel/first surface conceptual design for a commercial tokamak hybrid reactor

International Nuclear Information System (INIS)

Culbert, M.

1981-01-01

The purpose of this investigation was to develop a design concept for a commercial tokamak hybrid reactor (CTHR) vacuum vessel/first surface system which satisfies the engineering requirements for a commercial environment. An important distinction between the design constraints associated with 'pure' fusion and fusion-fission hybrid power reactors is that energy extraction from the first wall is not critical from the point of view of hybrid system economics. This allows the consideration of low temperature structural material for first wall application. The mechanical arrangement consists of a series of internally finned aluminium tube banks running poloidally around the torus. The coolant manifolds are at the top and bottom of the torus. The vessel is divided into sectors, the length of which depends on the spacing between TF coils. The tubes in each sector are welded to tube sheets which are in turn welded to semi-cylindrical manifolds which distribute the coolant uniformly to the tubes. The tubes, which are approx. equal to 2.5 cm in diameter at the manifold location, traverse the torus poloidal periphery and change from a circular cross section to a 2:1 elliptical cross section at the horizontal midplane. The arched tube is designed to be self-supporting between the manifold locations. The vacuum vessel's first surface will be plasma flamed sprayed aluminum applied to the tubular wall. (orig./GG)

Calculation of the electromagnetic forces on the ASDEX upgrade vacuum vessel on disruption of the plasma current

International Nuclear Information System (INIS)

Preis, H.

1986-01-01

This study investigates the magnetic field diffusion through the vacuum vessel of the ASDEX Upgrade tokamak that occurs on sudden disruption of the plasma current. Eddy currents are thereby produced in the vessel wall. Their time behaviour and distribution are determined. Furthermore, the vessel is permeated by various magnetic fields which, together with the eddy currents, exert magnetic forces in the vessel wall. These are also calculated. These numerical analyses are performed for two of the modes of operation envisaged for ASDEX Upgrade: the so-called limiter and single-null magnetic field configurations. (orig.)

Wall conditioning and leak localization in the advanced toroidal facility

International Nuclear Information System (INIS)

Langley, R.A.; Glowienka, J.C.; Mioduszewski, P.K.; Murakami, M.; Rayburn, T.F.; Simpkins, J.E.; Schwenterly, S.W.; Yarber, J.L.

1989-01-01

The Advanced Toroidal Facility (ATF) vacuum vessel and its internal components have been conditioned for plasma operation by baking, discharge cleaning with hydrogen and helium, and gettering with chromium and titanium. The plasma-facing surface of ATF consists mainly of stainless steel with some graphite; the outgassing area is dominated by the graphite because of its open porosity. Since this situation is somewhat different from that in other fusion plasma experiments, in which a single material dominates both the outgassing area and the plasma-facing area, different cleaning and conditioning techniques are required. The situation was aggravated by air leaks in the vacuum vessel, presumably resulting from baking and from vibration during plasma operation. The results of the various cleaning and conditioning techniques used are presented and compared on the basis of residual gas analysis and plasma performance. A technique for detecting leaks from the inside of the vacuum vessel is described; this technique was developed because access to the outside of the vessel is severely restricted by external components. 10 refs., 6 figs., 2 tabs

Wall conditioning and leak localization in the Advanced Toroidal Facility

International Nuclear Information System (INIS)

Langley, R.A.; Glowienka, J.C.; Mioduszewski, P.K.; Murakami, M.; Rayburn, T.F.; Simpkins, J.E.; Schwenterly, S.W.; Yarber, J.L.

1990-01-01

The Advanced Toroidal Facility (ATF) vacuum vessel and its internal components have been conditioned for plasma operation by baking, discharge cleaning with hydrogen and helium, and gettering with chromium and titanium. The plasma-facing surface of ATF consists mainly of stainless steel with some graphite; the outgassing area is dominated by the graphite because of its open porosity. Since this situation is somewhat different from that in other fusion plasma experiments, in which a single material dominates both the outgassing area and the plasma-facing area, different cleaning and conditioning techniques are required. The situation was aggravated by air leaks in the vacuum vessel, presumably resulting from baking and from vibration during plasma operation. The results of the various cleaning and conditioning techniques used are presented and compared on the basis of residual gas analysis and plasma performance. A technique for detecting leaks from the inside of the vacuum vessel is described. This technique was developed because access to the outside of the vessel is severely restricted by external components

ATF3 inhibits PPARγ-stimulated transactivation in adipocyte cells

Energy Technology Data Exchange (ETDEWEB)

Jang, Min-Kyung; Jung, Myeong Ho, E-mail: jung0603@pusan.ac.kr

2015-01-02

Highlights: • ATF3 inhibits PPARγ-stimulated transcriptional activation. • ATF3 interacts with PPARγ. • ATF3 suppresses p300-mediated transcriptional coactivation. • ATF3 decreases the binding of PPARγ and recruitment of p300 to PPRE. - Abstract: Previously, we reported that activating transcription factor 3 (ATF3) downregulates peroxisome proliferator activated receptor (PPARγ) gene expression and inhibits adipocyte differentiation in 3T3-L1 cells. Here, we investigated another role of ATF3 on the regulation of PPARγ activity. ATF3 inhibited PPARγ-stimulated transactivation of PPARγ responsive element (PPRE)-containing reporter or GAL4/PPARγ chimeric reporter. Thus, ATF3 effectively repressed rosiglitazone-stimulated expression of adipocyte fatty acid binding protein (aP2), PPARγ target gene, in 3T3-L1 cells. Coimmunoprecipitation and GST pulldown assay demonstrated that ATF3 interacted with PPARγ. Accordingly, ATF3 prevented PPARγ from binding to PPRE on the aP2 promoter. Furthermore, ATF3 suppressed p300-mediated transcriptional coactivation of PPRE-containing reporter. Chromatin immunoprecipitation assay showed that overexpression of ATF3 blocked both binding of PPARγ and recruitment of p300 to PPRE on aP2 promoter induced by rosiglitazone treatment in 3T3-L1 cells. Taken together, these results suggest that ATF3 interacts with PPARγ and represses PPARγ-mediated transactivation through suppression of p300-stimulated coactivation in 3T3-L1 cells, which may play a role in inhibition of adipocyte differentiation.

Design and performance tests of gas circulation heating of JT-60U vacuum vessel

International Nuclear Information System (INIS)

Yotsuga, M.; Masuzaki, T.; Sago, H.; Nishikane, M.; Uchikawa, T.; Iritani, Y.; Murakami, T.; Horiike, H.; Neyatani, Y.; Ninomiya, H.; Matsukawa, M.; Ando, T.; Miyachi, I.

1992-01-01

This paper reports that in the final stage of construction of the upgraded JT-60 device (JT-60U), baking tests of the vacuum vessel was performed. The vessel torus was heated-up to 300 degrees C by means of the nitrogen gas circulation system and electric heaters mounted on the outboard solid wall of the vessel. The design of the gas flow channels inside the double-wall structure of the vessel was done based on flow model tests, fluid analysis, and flow network analysis. The results of the baking tests were satisfactory. In maintaining 300 degrees C bake-out temperature, required heating power of the gas circulation system and outboard heaters was 520kW and 50kW, respectively. The temperature distribution over the vessel wall was within 300 ± 30 degrees C. It was also shown or suggested that heat-up and cool-down time is about 30 hours. The baking tests data have been reflected on operations for plasma experiments

Analysis on ingress of coolant event in vacuum vessel using modified TRAC-BF1 code

International Nuclear Information System (INIS)

Ajima, Toshio; Kurihara, Ryoichi; Seki, Yasushi

1999-08-01

The Transient Reactor Analysis Code (TRAC-BF1) was modified on the basis of ICE experimental results so as to analyze the Ingress of Coolant Event (ICE) in the vacuum vessel of a nuclear fusion reactor. In the previous report, the TRAC-BF1 code, which was originally developed for the safety analysis of a light water reactor, had been modified for the ICE of the fusion reactor. And the addition of the flat structural plate model to the VESSEL component and arbitrary appointment of the gravity direction had been added in the TRAC-BF1 code. This TRAC-BF1 code was further modified. The flat structural plate model of the VESSEL component was enabled to divide in multi layers having different materials, and a part of the multi layers could take a buried heater into consideration. Moreover, the TRAC-BF1 code was modified to analyze under the low-pressure condition close to vacuum within range of the steam table. This paper describes additional functions of the modified TRAC-BF1 code, analytical evaluation using ICE experimental data and the ITER model with final design report (FDR) data. (author)

FW/Blanket and vacuum vessel for RTO/RC ITER

International Nuclear Information System (INIS)

Ioki, K.; Barabash, V.; Cardella, A.; Elio, F.; Iida, H.; Johnson, G.; Kalinin, G.; Miki, N.; Onozuka, M.; Sannazzaro, G.; Utin, Y.; Yamada, M.

2000-01-01

The design has progressed on the vacuum vessel and First Wall (FW)/blanket for the Reduced Technical Objective/Reduced Cost (RTO/RC) ITER. The basic functions and structures are the same as for the 1998 ITER design. The design has been improved to achieve, along with the size reduction, ∼50% target reduction of the fabrication cost. The number of blanket modules has been minimized according to smaller dimensions of the machine and a higher payload capacity of the blanket Remote Handling tool. A concept without the back plate has been designed and assessed. The blanket module concept with flat separable FW panels has been developed to reduce the fabrication cost and future radioactive waste

FW/Blanket and vacuum vessel for RTO/RC ITER

Energy Technology Data Exchange (ETDEWEB)

Ioki, K. E-mail: iokik@itereu.de; Barabash, V.; Cardella, A.; Elio, F.; Iida, H.; Johnson, G.; Kalinin, G.; Miki, N.; Onozuka, M.; Sannazzaro, G.; Utin, Y.; Yamada, M

2000-11-01

The design has progressed on the vacuum vessel and First Wall (FW)/blanket for the Reduced Technical Objective/Reduced Cost (RTO/RC) ITER. The basic functions and structures are the same as for the 1998 ITER design. The design has been improved to achieve, along with the size reduction, {approx}50% target reduction of the fabrication cost. The number of blanket modules has been minimized according to smaller dimensions of the machine and a higher payload capacity of the blanket Remote Handling tool. A concept without the back plate has been designed and assessed. The blanket module concept with flat separable FW panels has been developed to reduce the fabrication cost and future radioactive waste.

Structural analysis of TFTR vacuum vessel bellows and bellows cover sections

International Nuclear Information System (INIS)

Driesen, G.

1975-10-01

A structural evaluation of the bellows and bellows cover sections was undertaken in order to confirm the structural integrity of these TFTR vacuum vessel components in the prescribed operating environment. The evaluations investigate component stability, stress, and deflection behavior. The products of this investigation appearing in this report include; (1) Structural verification of the vacuum bellows as currently defined in an operating environment of one atmosphere external pressure and 93 0 C (200 0 F) uniform temperature. (2) The establishment of a structurally adequate design configuration for the bellows cover section. (3) The presentation of a parametric study which indicates the effects of varying some bellows cover section parameters in order to obtain acceptable variations of this design configuration. (4) A verification of bellows and bellows cover section integrity to preclude a fatigue type failure for reactor startup and shutdown cyclic life in the design environment

The cellular transcription factor CREB corresponds to activating transcription factor 47 (ATF-47) and forms complexes with a group of polypeptides related to ATF-43.

Science.gov (United States)

Hurst, H C; Masson, N; Jones, N C; Lee, K A

1990-12-01

Promoter elements containing the sequence motif CGTCA are important for a variety of inducible responses at the transcriptional level. Multiple cellular factors specifically bind to these elements and are encoded by a multigene family. Among these factors, polypeptides termed activating transcription factor 43 (ATF-43) and ATF-47 have been purified from HeLa cells and a factor referred to as cyclic AMP response element-binding protein (CREB) has been isolated from PC12 cells and rat brain. We demonstrated that CREB and ATF-47 are identical and that CREB and ATF-43 form protein-protein complexes. We also found that the cis requirements for stable DNA binding by ATF-43 and CREB are different. Using antibodies to ATF-43 we have identified a group of polypeptides (ATF-43) in the size range from 40 to 43 kDa. ATF-43 polypeptides are related by their reactivity with anti-ATF-43, DNA-binding specificity, complex formation with CREB, heat stability, and phosphorylation by protein kinase A. Certain cell types vary in their ATF-43 complement, suggesting that CREB activity is modulated in a cell-type-specific manner through interaction with ATF-43. ATF-43 polypeptides do not appear simply to correspond to the gene products of the ATF multigene family, suggesting that the size of the ATF family at the protein level is even larger than predicted from cDNA-cloning studies.

BNL ATF II beamlines design

Energy Technology Data Exchange (ETDEWEB)

Fedurin, M. [Brookhaven National Lab. (BNL), Upton, NY (United States); Jing, Y. [Brookhaven National Lab. (BNL), Upton, NY (United States); Stratakis, D. [Brookhaven National Lab. (BNL), Upton, NY (United States); Swinson, C. [Brookhaven National Lab. (BNL), Upton, NY (United States)

2015-05-03

The Brookhaven National Laboratory. Accelerator Test Facility (BNL ATF) is currently undergoing a major upgrade (ATF-II). Together with a new location and much improved facilities, the ATF will see an upgrade in its major capabilities: electron beam energy and quality and CO₂ laser power. The electron beam energy will be increased in stages, first to 100-150 MeV followed by a further increase to 500 MeV. Combined with the planned increase in CO₂ laser power (from 1-100 TW), the ATF-II will be a powerful tool for Advanced Accelerator research. A high-brightness electron beam, produced by a photocathode gun, will be accelerated and optionally delivered to multiple beamlines. Besides the energy range (up to a possible 500 MeV in the final stage) the electron beam can be tailored to each experiment with options such as: small transverse beam size (<10 um), short bunch length (<100 fsec) and, combined short and small bunch options. This report gives a detailed overview of the ATFII capabilities and beamlines configuration.

Mineral trioxide aggregate induces osteoblastogenesis via Atf6

Directory of Open Access Journals (Sweden)

Toyonobu Maeda

2015-06-01

Full Text Available Mineral trioxide aggregate (MTA has been recommended for various uses in endodontics. To understand the effects of MTA on alveolar bone, we examined whether MTA induces osteoblastic differentiation using MC3T3-E1 cells. MTA enhanced mineralization concomitant with alkaline phosphatase activity in a dose- and time-dependent manner. MTA increased production of collagens (Type I and Type III and matrix metalloproteinases (MMP-9 and MMP-13, suggesting that MTA affects bone matrix remodeling. MTA also induced Bglap (osteocalcin but not Bmp2 (bone morphogenetic protein-2 mRNA expression. We observed induction of Atf6 (activating transcription factor 6, an endoplasmic reticulum (ER stress response transcription factor mRNA expression and activation of Atf6 by MTA treatment. Forced expression of p50Atf6 (active form of Atf6 markedly enhanced Bglap mRNA expression. Chromatin immunoprecipitation assay was performed to investigate the increase in p50Atf6 binding to the Bglap promoter region by MTA treatment. Furthermore, knockdown of Atf6 gene expression by introduction of Tet-on Atf6 shRNA expression vector abrogated MTA-induced mineralization. These results suggest that MTA induces in vitro osteoblastogenesis through the Atf6–osteocalcin axis as ER stress signaling. Therefore, MTA in endodontic treatment may affect alveolar bone healing in the resorbed region caused by pulpal infection.

A superconducting magnet upgrade of the ATF2 final focus

CERN Document Server

Parker, B; Escallier, J; He, P; Jain, P; Marone, A; Wanderer, P; Wu, KC; Hauviller, C; Marin, E; Tomas, R; Zimmermann, F; Bolzon, B; Jeremie, A; Kimura, N; Kubo, K; Kume, T; Kuroda, S; Okugi, T; Tauchi, T; Terunuma, N; Tomaru, T; Tsuchiya, K; Urakawa, J; Yamamoto, A; Bambade, P; Coe, P; Urner, D; Seryi, A; Spencer, C; White, G

2010-01-01

The ATF2 facility at KEK is a proving ground for linear collider technology with a well instrumented extracted beam line and Final Focus (FF). The primary ATF2 goal is to demonstrate the extreme beam demagnification and spot stability needed for a linear collider FF [1]. But the ATF2 FF uses water cooled magnets and the ILC baseline has a superconducting (SC) FF [2]. We plan to upgrade ATF2 and replace some of the warm FF magnets with SC FF magnets. The ATF2 SC magnets, like the ILC FF, will made via direct wind construction [3]. ATF2 coil winding is in progress at BNL and warm magnetic measurements indicate we have achieved good field quality. Studies indicate that having ATF2 FF magnets with larger aperture and better field quality should allow reducing the ATF2 FF beta function for study of focusing regimes relevant to CLIC [4]. The ATF2 magnet cryostat will have laser view ports for directly monitoring cold mass movement. We plan to make stability measurements at BNL and KEK to relate ATF2 FF magnet perfo...

Experimental and analytical investigations to air and steam ingress into the vacuum vessel of fusion reactors

International Nuclear Information System (INIS)

Kruessenberg, A.K.

1996-12-01

The basic fusion safety objective is the development of fusion power plants with features that protect individuals, society and the environment by establishing and maintaining an effective defence against radiological and other hazards. The most important specific principle is the establishment of three sequential levels of defence, characterized in priority order by prevention, protection and mitigation. The safety conscious selection of materials as one prevention feature gives the basis for the work described in this report. In order to protect the metallic first wall of fusion reactors from direct interaction with the plasma an extra armour is foreseen. Carbon offers the features low atomic number, high melting point, high thermal conductivity and good mechanical stability up to high temperatures making it to a favourite armour material. Looking on the safety behaviour of fusion reactors it has to be noted that carbon is unstable against oxidizing media like oxygen and steam at high temperatures und carbon has a high sorption capacity for radiologically important tritium. And tritium used as intermediate fuel in the actual reactor concepts is the one form radioactivity is present in fusion reactors. Accidents like loss of vacuum (LOVA) will lead to an air ingress into the vacuum vessel, oxidation of the hot carbon and a partial mobilization of the sorbed tritium. In a similar manner loss of coolant into vacuum (LOCIV) will lead to a water/steam ingress into the vacuum vessel, also accompanied by carbon oxidation and tritium release. (orig.)

Design and thermal/hydraulic characteristics of the ITER-FEAT vacuum vessel

International Nuclear Information System (INIS)

Onozuka, M.; Ioki, K.; Sannazzaro, G.; Utin, Y.; Yoshimura, H.

2001-01-01

Recent progress in structural design and thermal and hydraulic assessment of the vacuum vessel (VV) for ITER-FEAT is presented. Because of the direct attachment of the blanket modules to the VV, the module support structures are recessed into the double-wall VV, partially replacing the stiffening ribs between the VV shells to simplify the VV structure. Structural integrity of the VV is provided by the ribs and the module support structures with local reinforcement ribs. The detailed structural design of the VV taking account of the fabricability and code/standard acceptance is presented. Cost reduction of the VV fabrication using casting or forging is proposed. A high heat removal capability is required for the VV cooling to keep the thermal stress below the allowable. It is expected that natural thermo-gravitational convection due to the heat flux from the vessel wall to the water will enhance heat transfer characteristics even in the low flow velocity region

Design and thermal/hydraulic characteristics of the ITER-FEAT vacuum vessel

Energy Technology Data Exchange (ETDEWEB)

Onozuka, M. E-mail: onozukm@itereu.de; Ioki, K.; Sannazzaro, G.; Utin, Y.; Yoshimura, H

2001-11-01

Recent progress in structural design and thermal and hydraulic assessment of the vacuum vessel (VV) for ITER-FEAT is presented. Because of the direct attachment of the blanket modules to the VV, the module support structures are recessed into the double-wall VV, partially replacing the stiffening ribs between the VV shells to simplify the VV structure. Structural integrity of the VV is provided by the ribs and the module support structures with local reinforcement ribs. The detailed structural design of the VV taking account of the fabricability and code/standard acceptance is presented. Cost reduction of the VV fabrication using casting or forging is proposed. A high heat removal capability is required for the VV cooling to keep the thermal stress below the allowable. It is expected that natural thermo-gravitational convection due to the heat flux from the vessel wall to the water will enhance heat transfer characteristics even in the low flow velocity region.

Assembly of the sectors and ports of the ITER vacuum vessel

International Nuclear Information System (INIS)

Corino, S.; Moreno, R.

2014-01-01

The International Thermonuclear Experimental Reactor, ITER is a very complex Project that aims to prove the technical reliability of nuclear fusion. ITER has been Ensa's commitment to the future to strengthen as one of the main manufacturers of big equipment and services internationally in the nuclear field. Ensa started working on the qualification process to be able to bid for the 'Assembly of the ITER vacuum vessel' in June 2010, after two and a half years of pre-qualification, offers, clarifications and long technical meetings, that were followed by commercial meetings Ensa achieved its goal. The 30 of November, Ensa signed what at that time was the biggest of the supplies signed by IO (ITER Organization). A lot of efforts and hard work had been done in order to achieve this goal, but the hardest of all was yet to come, after the signature of the contract, Ensa has 7 years ahead to achieve the final goal, the assembly and welding of the 9 sectors that put together the ITER vacuum vessel and the 54 ports that will allow the assembly of the different auxiliary systems. The scope of the works to be performed can generally be divided into the following areas: - Welding of the sectors and ports; - Non-destructive tests; - Machining; - Dimensional Controls. In order to achieve this goal, the project has been divided into 3 different phases. - Development phase: January 2013 - July 2015; - Pre-production phase: July 2015 - February 2016; - Production phase: February 2016 - February 2020

Possible incorporation of a dee-shaped vacuum vessel in Doublet III

International Nuclear Information System (INIS)

Davis, L.; Rawls, J.M.

1979-11-01

The design of Doublet III allows relative straightforward incorporation of any of a number of possible dee-configuration vacuum vessels that can serve as relevant size tests of reactor regime devices. Configurations simulating those of JET, ETF and INTOR with plasma areas larger than TFTR can be attained with significant physics parameter results. Such modifications to Doublet III could be incorporated into planned upgrade activites with operations beginning in 1984, early enough to influence the designs of ETF and INTOR and test the scaling laws, poloidal coil system, and impurity control systems proposed for these ignition devices

ATF [Advanced Toroidal Facility] data management

International Nuclear Information System (INIS)

Kannan, K.L.; Baylor, L.R.

1988-01-01

Data management for the Advanced Toroidal Facility (ATF), a stellarator located at Oak Ridge National Laboratory (ORNL), is provided by DMG, a locally developed, VAX-based software system. DMG is a data storage and retrieval software system that provides the user interface to ATF raw and analyzed data. Data are described in terms of data models and data types and are organized as signals into files, which are internally documented. The system was designed with user accessibility, software maintainability, and extensibility as primary goals. Extensibility features include compatibility with ATF as it moves from pulsed to steady-state operation and capability for use of the DMG system with experiments other than ATF. DMG is implemented as a run-time library of routines available as a shareable image. General-purpose and specialized data acquisition and analysis applications have been developed using the DMG system. This paper describes the DMG system and the interfaces to it. 4 refs., 2 figs

Progress and achievements of R&D activities for the ITER vacuum vessel

Science.gov (United States)

Nakahira, M.; Takahashi, H.; Koizumi, K.; Onozuka, M.; Ioki, K.

2001-04-01

The Full Scale Sector Model Project, which was initiated in 1995 as one of the Seven Large Projects for ITER R&D, has been continued with the joint effort of the ITER Joint Central Team and the Japanese, Russian Federation and United States Home Teams. The fabrication of a full scale 18° toroidal sector, which is composed of two 9° sectors spliced at the port centre, was successfully completed in September 1997 with a dimensional accuracy of +/-3 mm for the total height and total width. Both sectors were shipped to the test site at the Japan Atomic Energy Research Institute and the integration test of the sectors was begun in October 1997. The integration test involves the adjustment of field joints, automatic narrow gap tungsten inert gas welding of field joints with splice plates and inspection of the joints by ultrasonic testing, as required for the initial assembly of the ITER vacuum vessel. This first demonstration of field joint welding and the performance test of the mechanical characteristics were completed in May 1998, and all the results obtained have satisfied the ITER design. In addition to these tests, integration with the midplane port extension fabricated by the Russian Home Team by using a fully remotized welding and cutting system developed by the US Home Team was completed in March 2000. The article describes the progress, achievements and latest status of the R&D activities for the ITER vacuum vessel.

Design and development of the ITER vacuum vessel

Energy Technology Data Exchange (ETDEWEB)

Koizumi, K.; Nakahira, M.; Itou, Y.; Tada, E. [Japan Atomic Energy Research Inst., Naka, Ibaraki (Japan); Johnson, G.; Ioki, K.; Elio, F.; Iizuka, T.; Sannazzaro, G.; Takahashi, K.; Utin, Y.; Onozuka, M. [ITER Joint Central Team (JCT), Garching (Germany); Nelson, B. [US Home Team, Oak Ridge National Laboratory (United States); Vallone, C. [EU Home Team, NET Team, Garching (Germany); Kuzmin, E. [RF Home Team, Efremov Institute, City (Russian Federation)

1998-09-01

In ITER, the vacuum vessel (VV) is designed to be a water cooled, double-walled toroidal structure made of 316LN stainless steel with a D-shaped cross section approximately 9 m wide and 15 m high. The design work which began at the beginning of the ITER-EDA is nearing completion by resolving the technical issues. In parallel with the design activities, the R and D program, full-scale VV sector model project, was initiated in 1995 to resolve the design and fabrication issues. The full-scale sector model corresponds to an 18 sector (9 sub-sector x 2) and is being fabricated on schedule. To date, 60% of the fabrication had been completed. The fabrication of full-scale model including sector-to-sector connection will be completed by the end of 1997 and performance tests are scheduled until the end of ITER-EDA. This paper describes the latest status of the ITER VV design and the full-scale sector model project. (orig.) 3 refs.

Clearance potential of ITER vacuum vessel activated materials

International Nuclear Information System (INIS)

Cepraga, D.G.; Cambi, G.; Frisoni, M.

2002-01-01

To demonstrate fusion's environmental attractiveness over the entire life cycle, a waste analysis is mandatory. The clearance is recommended by IAEA for releasing activated solid materials from regulatory control and for waste management policy. The paper focuses on the approach used to support waste analyses for ITER Generic Site Safety Report. The Material Unconditional Clearance Index of all the materials/zones on the equatorial mid-plane of ITER machine have been evaluated, based on IAEA-TECDOC-855. The Bonami-Nitawl-XSDNRPM sequence of the Scale-4.4a code system (using Vitenea-J library) has been firstly used for radiation transport analyses. Then the Anita-2000 code package is used for the activation calculation. The paper presents also, as an example, an application of the clearance indexes estimation for the ITER vacuum vessel materials. The results of the Anita-2000 have been compared with those obtained using the Fispact-99 activation code. (author)

IWR-solution for the ITER vacuum vessel assembly

Energy Technology Data Exchange (ETDEWEB)

Wu, H., E-mail: huapeng@lut.fi [Laboratory of Intelligent Machines, Lappeenranta University of Technology (Finland); Handroos, H. [Laboratory of Intelligent Machines, Lappeenranta University of Technology (Finland); Pela, P. [Tekes (Finland); Wang, Y. [Laboratory of Intelligent Machines, Lappeenranta University of Technology (Finland)

2011-10-15

The assembly of ITER vacuum vessel (VV) is still a very big challenge as the process can only be done from inside the VV. The welding of the VV assembly is carried out using the dedicated robotic systems. The main functions of the robots are: (i) measuring the actual space between every two sectors, (ii) positioning of the 150 kg splice plates between the sector shells, (iii) welding the splice plates to the sector shells, (iv) NDT of the welds, (v) repairing, including machining of the welds, (vi) He-leak tests of the welds, and (vii) the non-planned functions that may turn out. This paper presents a reasonable method to assemble the ITER VV. In this article, one parallel mobile robot, running on the track rail fixed on the wall inside the VV, is designed and tested. The assembling process, carried out by the mobile robot together with the welding robot, is presented.

Function and regulation of ATF 3 expression induced by ionizing radiation

International Nuclear Information System (INIS)

Fan, Feiyue; Wang, Yong; Du, Liqin; Zhan, Qimin

2008-01-01

Full text: Ionizing radiation results in a series of damages of mammalian cells as a genotoxic stress. There are some genes expressed after cells damaged, in which ATF 3, a member of ATF/CREB family of transcription factors, is one of them. In this report, we demonstrate that ATF 3 can be induced by ionizing radiation. The induction of ATF 3 protein requires normal status of p53 function in cells. There are some quantitative relationships between ATF 3 induction and dosages of radiation or time post-irradiation. In another word, ATF 3 expression induced by ionizing radiation present dose- and time-dependent. The regulation of ATF 3 expression refers to program of promoter and transcription. Radiation induces ATF 3 expression by activating the promoter and RNA transcription. In method of tetracycline-inducible system (tet-off), we have found that over-expression of ATF 3 protein brings caspase/PARP proteins into cleavage, which induces cell programmed death, and suppresses cell growth. Meanwhile, it was found that ATF 3 expression could slow down progression of cell from G 1 to S phase. It indicates ATF 3 protein might play a negative role in the control of cell cycle progression. It is very excited that expression of ATF 3 protein did not only suppress cell growth, but also demonstrated protecting effect of cell growth suppression resulting from ionizing radiation. It is suggested that ATF 3 protein might take part in the damage repair process of cells. (author)

Mechanical impacts of poloidal eddy currents on the continuous vacuum vessel of a tokamak

International Nuclear Information System (INIS)

In, Sang Ryul; Yoon, Byung Joo.

1996-11-01

Poloidal eddy currents are induced on the continuous torus vacuum vessel by changes of the toroidal field during the machine start-up (toroidal field coil charge), shut-down (toroidal field coil discharge) and plasma disruption (plasma diamagnetism change). Analytic forms for the eddy currents flowing on the vessel, consequent pressures and forces acting on it are presented in this report. The results are applied to typical operation modes of the KT-2 tokamak. Stress analysis for two typical operation modes of toroidal field damping during a machine shut-gown and plasma energy quench during a plasma disruption were carried out using 3D FEM code (ANSYS 5.2). (author). 5 tabs., 22 figs., 9 refs

Novel Robot Solutions for Carrying out Field Joint Welding and Machining in the Assembly of the Vacuum Vessel of ITER

International Nuclear Information System (INIS)

Pessi, P.

2009-01-01

It is necessary to use highly specialized robots in ITER (International Thermonuclear Experimental Reactor) both in the manufacturing and maintenance of the reactor due to a demanding environment. The sectors of the ITER vacuum vessel (VV) require more stringent tolerances than normally expected for the size of the structure involved. VV consists of nine sectors that are to be welded together. The vacuum vessel has a toroidal chamber structure. The task of the designed robot is to carry the welding apparatus along a path with a stringent tolerance during the assembly operation. In addition to the initial vacuum vessel assembly, after a limited running period, sectors need to be replaced for repair. Mechanisms with closed-loop kinematic chains are used in the design of robots in this work. One version is a purely parallel manipulator and another is a hybrid manipulator where the parallel and serial structures are combined. Traditional industrial robots that generally have the links actuated in series are inherently not very rigid and have poor dynamic performance in high speed and high dynamic loading conditions. Compared with open chain manipulators, parallel manipulators have high stiffness, high accuracy and a high force/torque capacity in a reduced workspace. Parallel manipulators have a mechanical architecture where all of the links are connected to the base and to the end-effector of the robot. The purpose of this thesis is to develop special parallel robots for the assembly, machining and repairing of the VV of the ITER. The process of the assembly and machining of the vacuum vessel needs a special robot. By studying the structure of the vacuum vessel, two novel parallel robots were designed and built; they have six and ten degrees of freedom driven by hydraulic cylinders and electrical servo motors. Kinematic models for the proposed robots were defined and two prototypes built. Experiments for machine cutting and laser welding with the 6-DOF robot were

Novel Robot Solutions for Carrying out Field Joint Welding and Machining in the Assembly of the Vacuum Vessel of ITER

Energy Technology Data Exchange (ETDEWEB)

Pessi, P.

2009-07-01

It is necessary to use highly specialized robots in ITER (International Thermonuclear Experimental Reactor) both in the manufacturing and maintenance of the reactor due to a demanding environment. The sectors of the ITER vacuum vessel (VV) require more stringent tolerances than normally expected for the size of the structure involved. VV consists of nine sectors that are to be welded together. The vacuum vessel has a toroidal chamber structure. The task of the designed robot is to carry the welding apparatus along a path with a stringent tolerance during the assembly operation. In addition to the initial vacuum vessel assembly, after a limited running period, sectors need to be replaced for repair. Mechanisms with closed-loop kinematic chains are used in the design of robots in this work. One version is a purely parallel manipulator and another is a hybrid manipulator where the parallel and serial structures are combined. Traditional industrial robots that generally have the links actuated in series are inherently not very rigid and have poor dynamic performance in high speed and high dynamic loading conditions. Compared with open chain manipulators, parallel manipulators have high stiffness, high accuracy and a high force/torque capacity in a reduced workspace. Parallel manipulators have a mechanical architecture where all of the links are connected to the base and to the end-effector of the robot. The purpose of this thesis is to develop special parallel robots for the assembly, machining and repairing of the VV of the ITER. The process of the assembly and machining of the vacuum vessel needs a special robot. By studying the structure of the vacuum vessel, two novel parallel robots were designed and built; they have six and ten degrees of freedom driven by hydraulic cylinders and electrical servo motors. Kinematic models for the proposed robots were defined and two prototypes built. Experiments for machine cutting and laser welding with the 6-DOF robot were

Vacuum system of SST-1 Tokamak

International Nuclear Information System (INIS)

Khan, Ziauddin; Pathan, Firozkhan; George, Siju; Semwal, Pratibha; Dhanani, Kalpesh; Paravastu, Yuvakiran; Thankey, Prashant; Ramesh, Gattu; Himabindu, Manthena; Pradhan, Subrata

2013-01-01

Highlights: ► Air leaks developed during ongoing SST-1 cooldown campaign were detected online using RGA. ► The presence of N 2 and O 2 gases with the ratio of their partial pressures with ∼3.81:1 confirmed the air leaks. ► Baking of SST-1 was done efficiently by flowing hot N 2 gas in C-channels welded on inner surfaces without any problem. ► In-house fabricated demountable bull nose couplers were demonstrated for high temperature and pressure applications. ► Cryopumping effect was observed when liquid helium cooled superconducting magnets reached below 63 K. -- Abstract: Vacuum chambers of Steady State Superconducting (SST-1) Tokamak comprises of the vacuum vessel and the cryostat. The plasma will be confined inside the vacuum vessel while the cryostat houses the superconducting magnet systems (TF and PF coils), LN 2 cooled thermal shields and hydraulics for these circuits. The vacuum vessel is an ultra-high (UHV) vacuum chamber while the cryostat is a high-vacuum (HV) chamber. In order to achieve UHV inside the vacuum vessel, it would be baked at 150 °C for longer duration. For this purpose, U-shaped baking channels are welded inside the vacuum vessel. The baking will be carried out by flowing hot nitrogen gas through these channels at 250 °C at 4.5 bar gauge pressure. During plasma operation, the pressure inside the vacuum vessel will be raised between 1.0 × 10 −4 mbar and 1.0 × 10 −5 mbar using piezoelectric valves and control system. An ultimate pressure of 4.78 × 10 −6 mbar is achieved inside the vacuum vessel after 100 h of pumping. The limitation is due to the development of few leaks of the order of 10 −5 mbar l/s at the critical locations of the vacuum vessel during baking which was confirmed with the presence of nitrogen gas and oxygen gas with the ratio of ∼3.81:1 indicating air leak. Similarly an ultimate vacuum of 2.24 × 10 −5 mbar is achieved inside the cryostat. Baking of the vacuum vessel up to 110 °C with ±10 �

Weld distortion prediction and control of the ITER vacuum vessel manufacturing mock-ups

International Nuclear Information System (INIS)

Ottolini, Marco; Barbensi, Andrea

2014-01-01

The fabrication of the ITER Vacuum Vessel Sectors is an unprecedented challenge, due to their dimensions, the close tolerances, the complex 'D' shape. The technological issues were faced by the production of full scale mock ups to confirm the manufacturing feasibility to achieve very tight tolerances and qualify the main manufacturing processes, by a step by step welding distortion control, by the qualification of not conventional NDT inspection techniques and by innovative 3D dimensional inspections. The Supplier is required to fabricate at least two mock ups, inboard and outboard, related to the manufacturing method of the VV Sectors, to demonstrate the control of the welding distortions to achieve tolerances, optimizing welding sequences and calibrating of welding distortions computer simulations. The stages of this preparatory activity are: prediction of welding distortion for fabrication mock ups representative of selected segments; demonstration that distortion predictions are consistent with experimental results from 3D dimensional inspection; understanding of reasons of possible deviations between numerical and experimental results and definition of action to solve these issues; demonstration that possible calculation simplifications, adopted to speed up the analysis process, do not affect significantly the welding distortion prediction. This paper describes the weld distortion prediction and control on the manufacturing mock-ups of ITER Vacuum Vessel Sectors, with particular emphasis to the lessons learned. (authors)

Brain-Derived Neurotrophic Factor Elevates Activating Transcription Factor 4 (ATF4 in Neurons and Promotes ATF4-Dependent Induction of Sesn2

Directory of Open Access Journals (Sweden)

Jin Liu

2018-03-01

Full Text Available Activating transcription factor 4 (ATF4 plays important physiologic roles in the brain including regulation of learning and memory as well as neuronal survival and death. Yet, outside of translational regulation by the eIF2α-dependent stress response pathway, there is little information about how its levels are controlled in neurons. Here, we show that brain-derived neurotrophic factor (BDNF promotes a rapid and sustained increase in neuronal ATF4 transcripts and protein levels. This increase is dependent on tropomyosin receptor kinase (TrkB signaling, but independent of levels of phosphorylated eIF2α. The elevation in ATF4 protein occurs both in nuclei and processes. Transcriptome analysis revealed that ATF4 mediates BDNF-promoted induction of Sesn2 which encodes Sestrin2, a protector against oxidative and genotoxic stresses and a mTor complex 1 inhibitor. In contrast, BDNF-elevated ATF4 did not affect expression of a number of other known ATF4 targets including several with pro-apoptotic activity. The capacity of BDNF to elevate neuronal ATF4 may thus represent a means to maintain this transcription factor at levels that provide neuroprotection and optimal brain function without risk of triggering neurodegeneration.

Manufacturing technology development for vacuum vessel and plasma facing components

International Nuclear Information System (INIS)

Laitinen, Arttu; Liimatainen, Jari; Hallila, Pentti

2005-01-01

Vacuum vessel and plasma facing components of the ITER construction including shield modules and primary first wall panels have great impact on the production costs and reliability of the installation. From the manufacturing technology point of view, accuracy of shape, properties of the various austenitic stainless steel/austenitic stainless steel interfaces or CuCrZr/austenitic stainless steel interfaces as well as those of the base materials are crucial for technical reliability of the construction. The current approach in plasma facing components has been utilisation of solid-HIP technology and solid-powder-HIP technology. Due to the large size of especially shield modules shape, control of the internal cavities and cooling channels is extremely demanding. This requires strict control of the raw materials and manufacturing parameters

Design study of a new vacuum vessel for Doublet III

International Nuclear Information System (INIS)

Rawls, J.M.; Davis, L.G.; Anderson, P.M.

1980-10-01

The principal thrust of the project was to examine a single design in enough depth to gain confidence in the feasibility and desirability of specific design features. However, a valuable spin-off of the project was to develop information of a more generic character to aid in future studies of possibilities for Doublet III. For example, we now feel that Doublet III can be reconfigured with any of a variety of new vacuum vessels, poloidal coil sets, and auxiliary heating systems within three years of project initiation, a period that is short compared to the time scale for developing a completely new facility. In addition, this can be accomplished at a fraction of the cost required to develop a comparable facility

DSTAR: A comprehensive tokamak resistive disruption model for vacuum vessel components

International Nuclear Information System (INIS)

Merrill, B.J.; Jardin, S.C.

1987-01-01

A computer code, DSTAR, has recently been developed to quantify the surface erosion and induced forces than can occur during major tokamak plasma disruptions. A disruption analysis has been performed for the TFCX fusion device. The limiters and inboard first wall were assumed to be clad with beryllium. Disruption simulations were performed with and without these structures present, to determine their electromagnetic influence. The results with structure show that the ablated wall material is transported poloidally, as well as radially, in the plasma causing the outermost regions of the plasma to cool. The plasma moves downward and deforms while maintaining contact with the lower limiter. This motion maintains the peak impurity radiant source directly above the exposed surface. For the disruption simulation without the vacuum vessel included, the plasma moves radially along the lower limiter until it contacts the inboard wall, causing ablation of this surface as well. The conclusion is drawn that disruption simulations that do not include both the thermal and electromagnetic response of the vaccum vessel will not result in an accurate prediction. (orig.)

ATF3 inhibits adipocyte differentiation of 3T3-L1 cells

International Nuclear Information System (INIS)

Jang, Min Kyung; Kim, Cho Hee; Seong, Je Kyung; Jung, Myeong Ho

2012-01-01

Highlights: ► Overexpression of ATF3 inhibits adipocyte differentiation in 3T3-L1 cells. ► Overexpression of ATF3 represses C/EBPα expression. ► ATF3 directly binds to mouse C/EBPα promoter spanning from −1928 to −1907. ► ATF3 may play a role in hypoxia-mediated inhibition of adipocyte differentiation. -- Abstract: ATF3 is a stress-adaptive gene that regulates proliferation or apoptosis under stress conditions. However, the role of ATF3 is unknown in adipocyte cells. Therefore, in this study, we investigated the functional role of ATF3 in adipocytes. Both lentivirus-mediated overexpression of ATF3 and stably-overexpressed ATF3 inhibited adipocyte differentiation in 3T3-L1 cells, as revealed by decreased lipid staining with oil red staining and reduction in adipogenic genes. Thapsigargin treatment and overexpression of ATF3 decreased C/EBPα transcript and repressed the activity of the 3.6-kb mouse C/EBPα promoter, demonstrating that ATF3 downregulates C/EBPα expression. Transfection studies using mutant constructs containing 5′-deletions in the C/EBPα promoter revealed that a putative ATF/CRE element, GGATGTCA, is located between −1921 and −1914. Electrophoretic mobility shift assay and chromatin immunoprecipitation assay demonstrated that ATF3 directly binds to mouse C/EBPα promoter spanning from −1928 to −1907. Both chemical hypoxia-mimetics or physical hypoxia led to reduce the C/EBPα mRNA and repress the promoter activity of the C/EBPα gene, whereas increase ATF3 mRNA, suggesting that ATF3 may contribute to the inhibition of adipocyte differentiation in hypoxia through downregulation of C/EBPα expression. Collectively, these results demonstrate that ATF3 represses the C/EBPα gene, resulting in inhibition of adipocyte differentiation, and thus plays a role in hypoxia-mediated inhibition of adipocyte differentiation.

Vacuum system of SST-1 Tokamak

Energy Technology Data Exchange (ETDEWEB)

Khan, Ziauddin, E-mail: ziauddin@ipr.res.in [Institute for Plasma Research, Near Indira Bridge, Bhat, Gandhinagar 382 428 (India); Pathan, Firozkhan; George, Siju; Semwal, Pratibha; Dhanani, Kalpesh; Paravastu, Yuvakiran; Thankey, Prashant; Ramesh, Gattu; Himabindu, Manthena; Pradhan, Subrata [Institute for Plasma Research, Near Indira Bridge, Bhat, Gandhinagar 382 428 (India)

2013-10-15

Highlights: ► Air leaks developed during ongoing SST-1 cooldown campaign were detected online using RGA. ► The presence of N{sub 2} and O{sub 2} gases with the ratio of their partial pressures with ∼3.81:1 confirmed the air leaks. ► Baking of SST-1 was done efficiently by flowing hot N{sub 2} gas in C-channels welded on inner surfaces without any problem. ► In-house fabricated demountable bull nose couplers were demonstrated for high temperature and pressure applications. ► Cryopumping effect was observed when liquid helium cooled superconducting magnets reached below 63 K. -- Abstract: Vacuum chambers of Steady State Superconducting (SST-1) Tokamak comprises of the vacuum vessel and the cryostat. The plasma will be confined inside the vacuum vessel while the cryostat houses the superconducting magnet systems (TF and PF coils), LN{sub 2} cooled thermal shields and hydraulics for these circuits. The vacuum vessel is an ultra-high (UHV) vacuum chamber while the cryostat is a high-vacuum (HV) chamber. In order to achieve UHV inside the vacuum vessel, it would be baked at 150 °C for longer duration. For this purpose, U-shaped baking channels are welded inside the vacuum vessel. The baking will be carried out by flowing hot nitrogen gas through these channels at 250 °C at 4.5 bar gauge pressure. During plasma operation, the pressure inside the vacuum vessel will be raised between 1.0 × 10{sup −4} mbar and 1.0 × 10{sup −5} mbar using piezoelectric valves and control system. An ultimate pressure of 4.78 × 10{sup −6} mbar is achieved inside the vacuum vessel after 100 h of pumping. The limitation is due to the development of few leaks of the order of 10{sup −5} mbar l/s at the critical locations of the vacuum vessel during baking which was confirmed with the presence of nitrogen gas and oxygen gas with the ratio of ∼3.81:1 indicating air leak. Similarly an ultimate vacuum of 2.24 × 10{sup −5} mbar is achieved inside the cryostat. Baking of the

Multi-scenario evaluation and specification of electromagnetic loads on ITER vacuum vessel

International Nuclear Information System (INIS)

Rozov, Vladimir; Martinez, J.-M.; Portafaix, C.; Sannazzaro, G.

2014-01-01

Highlights: • We present the results of multi-scenario analysis of EM loads on ITER vacuum vessel (VV). • The differentiation of models provides the economic way to perform big amount of calculations. • Functional approximation is proposed for distributed data/FE/numerical results specification. • Examples of specification of the load profiles by trigonometric polynomials (DHT) are given. • Principles of accounting for toroidal asymmetry at EM interactions in tokamak are considered. - Abstract: The electro-magnetic (EM) transients cause mechanical forces, which represent one of the most critical loads for the ITER vacuum vessel (VV). The paper is focused on the results of multi-scenario analysis and systematization of these EM loads, including specifically addressed pressures on shells and the net vertical force. The proposed mathematical model and computational technology, based on the use of integral parameters and operational analysis methods, enabled qualitative and quantitative analysis of the problem, time-efficient computations and systematic assessment of a large number of scenarios. The obtained estimates, found envelopes and peak values exemplify the principal loads on the VV and provide a database to support engineering load specifications. Special attention is given to the challenge of specification and documenting of the results in a form, suitable for using the data in engineering applications. The practical aspects of specification of distributed data, such as experimental and finite-element (FE) results, by analytical interpolants are discussed. The example of functional approximation of the load profiles by trigonometric polynomials based on discrete Hartley transform (DHT) is given

Multi-scenario evaluation and specification of electromagnetic loads on ITER vacuum vessel

Energy Technology Data Exchange (ETDEWEB)

Rozov, Vladimir, E-mail: vladimir.rozov@iter.org; Martinez, J.-M.; Portafaix, C.; Sannazzaro, G.

2014-10-15

Highlights: • We present the results of multi-scenario analysis of EM loads on ITER vacuum vessel (VV). • The differentiation of models provides the economic way to perform big amount of calculations. • Functional approximation is proposed for distributed data/FE/numerical results specification. • Examples of specification of the load profiles by trigonometric polynomials (DHT) are given. • Principles of accounting for toroidal asymmetry at EM interactions in tokamak are considered. - Abstract: The electro-magnetic (EM) transients cause mechanical forces, which represent one of the most critical loads for the ITER vacuum vessel (VV). The paper is focused on the results of multi-scenario analysis and systematization of these EM loads, including specifically addressed pressures on shells and the net vertical force. The proposed mathematical model and computational technology, based on the use of integral parameters and operational analysis methods, enabled qualitative and quantitative analysis of the problem, time-efficient computations and systematic assessment of a large number of scenarios. The obtained estimates, found envelopes and peak values exemplify the principal loads on the VV and provide a database to support engineering load specifications. Special attention is given to the challenge of specification and documenting of the results in a form, suitable for using the data in engineering applications. The practical aspects of specification of distributed data, such as experimental and finite-element (FE) results, by analytical interpolants are discussed. The example of functional approximation of the load profiles by trigonometric polynomials based on discrete Hartley transform (DHT) is given.

A mobile robot with parallel kinematics constructed under requirements for assembling and machining of the ITER vacuum vessel

International Nuclear Information System (INIS)

Pessi, P.; Huapeng Wu; Handroos, H.; Jones, L.

2006-01-01

ITER sectors require more stringent tolerances ± 5 mm than normally expected for the size of structure involved. The walls of ITER sectors are made of 60 mm thick stainless steel and are joined together by high efficiency structural and leak tight welds. In addition to the initial vacuum vessel assembly, sectors may have to be replaced for repair. Since commercially available machines are too heavy for the required machining operations and the lifting of a possible e-beam gun column system, and conventional robots lack the stiffness and accuracy in such machining condition, a new flexible, lightweight and mobile robotic machine is being considered. For the assembly of the ITER vacuum vessel sector, precise positioning of welding end-effectors, at some distance in a confined space from the available supports, will be required, which is not possible using conventional machines or robots. This paper presents a special robot, able to carry out welding and machining processes from inside the ITER vacuum vessel, consisting of a ten-degree-of-freedom parallel robot mounted on a carriage driven by electric motor/gearbox on a track. The robot consists of a Stewart platform based parallel mechanism. Water hydraulic cylinders are used as actuators to reach six degrees of freedom for parallel construction. Two linear and two rotational motions are used for enlargement the workspace of the manipulator. The robot carries both welding gun such as a TIG, hybrid laser or e-beam welding gun to weld the inner and outer walls of the ITER vacuum vessel sectors and machining tools to cut and milling the walls with necessary accuracy, it can also carry other tools and material to a required position inside the vacuum vessel . For assembling an on line six degrees of freedom seam finding algorithm has been developed, which enables the robot to find welding seam automatically in a very complex environment. In the machining multi flexible machining processes carried out automatically by

Fundamental study of a water jet injected into a vacuum vessel of fusion reactor under the ingress of coolant event

International Nuclear Information System (INIS)

Takase, Kazuyuki; Kunugi, Tomoaki; Seki, Yasushi; Kurihara, Ryouichi; Ueda, Shuzou

1996-01-01

As one of some transient sequences for the thermofluid safety in ITER, pressure rise and boiling heat transfer characteristics in a Tokamak vacuum vessel during an ingress of coolant event (ICE) are being investigated experimentally by using the preliminary ICE apparatus. The pressure rise rates in the vacuum vessel and the wall temperature distributions on the target plate were measured quantitatively and clarified at first. In addition, a two-phase flow under the ICE conditions was analyzed numerically for predicting the experimental results using one-dimensional transport equations and the drift-flux model. The experimental results were compared with the numerical results. It was found that the pressurization behavior during the ICE conditions could be estimated qualitatively by the present numerical analyses. 5 refs., 5 figs

Conditioning of SST-1 Tokamak Vacuum Vessel by Baking and Glow Discharge Cleaning

International Nuclear Information System (INIS)

Khan, Ziauddin; George, Siju; Semwal, Pratibha; Dhanani, Kalpeshkumar R.; Pathan, Firozkhan S.; Paravastu, Yuvakiran; Raval, Dilip C.; Babu, Gattu Ramesh; Khan, Mohammed Shoaib; Pradhan, Subrata

2016-01-01

Highlights: • SST-1 Tokamak was successfully commissioned. • Vacuum vessel was pumped down to 4.5 × 10"–"8 mbar after baking and continuous GDC. • GDC reduced the water vapour by additional 57% while oxygen was reduced by 50%. • Under this condition, an initial plasma breakdown with current of 40 kA for 75 ms was achieved. - Abstract: Steady-state Superconducting Tokamak (SST-1) vacuum vessel (VV) adopts moderate baking at 110 ± 10 °C and the limiters baking at 250 ± 10 °C for ∼ 200 h followed by glow discharge cleaning in hydrogen (GDC-H) with 0.15 A/m"2 current density towards its conditioning prior to plasma discharge experiment. The baking in SST-1 reduces the water (H_2O) vapor by 95% and oxygen (O_2) by 60% whereas the GDC reduces the water vapor by an additional 57% and oxygen by another 50% as measured with residual gas analyzer. The minimum breakdown voltage for H-GDC in SST-1 tokamak was experimentally observed to 300 V at 8 mbar cm. As a result of these adherences, SST-1 VV achieves an ultimate of 4.5 × 10"−"8 mbar with two turbo-molecular pumps with effective pumping speed of 3250 l/s. In the last campaign, SST-1 has achieved successful plasma breakdown, impurity burn through and a plasma current of ∼ 40 kA for 75 ms.

Conditioning of SST-1 Tokamak Vacuum Vessel by Baking and Glow Discharge Cleaning

Energy Technology Data Exchange (ETDEWEB)

Khan, Ziauddin, E-mail: ziauddin@ipr.res.in; George, Siju; Semwal, Pratibha; Dhanani, Kalpeshkumar R.; Pathan, Firozkhan S.; Paravastu, Yuvakiran; Raval, Dilip C.; Babu, Gattu Ramesh; Khan, Mohammed Shoaib; Pradhan, Subrata

2016-02-15

Highlights: • SST-1 Tokamak was successfully commissioned. • Vacuum vessel was pumped down to 4.5 × 10{sup –8} mbar after baking and continuous GDC. • GDC reduced the water vapour by additional 57% while oxygen was reduced by 50%. • Under this condition, an initial plasma breakdown with current of 40 kA for 75 ms was achieved. - Abstract: Steady-state Superconducting Tokamak (SST-1) vacuum vessel (VV) adopts moderate baking at 110 ± 10 °C and the limiters baking at 250 ± 10 °C for ∼ 200 h followed by glow discharge cleaning in hydrogen (GDC-H) with 0.15 A/m{sup 2} current density towards its conditioning prior to plasma discharge experiment. The baking in SST-1 reduces the water (H{sub 2}O) vapor by 95% and oxygen (O{sub 2}) by 60% whereas the GDC reduces the water vapor by an additional 57% and oxygen by another 50% as measured with residual gas analyzer. The minimum breakdown voltage for H-GDC in SST-1 tokamak was experimentally observed to 300 V at 8 mbar cm. As a result of these adherences, SST-1 VV achieves an ultimate of 4.5 × 10{sup −8} mbar with two turbo-molecular pumps with effective pumping speed of 3250 l/s. In the last campaign, SST-1 has achieved successful plasma breakdown, impurity burn through and a plasma current of ∼ 40 kA for 75 ms.

Progress and achievements of R and D activities for the ITER vacuum vessel

International Nuclear Information System (INIS)

Nakahira, M.; Takahashi, H.; Koizumi, K.; Onozuka, M.; Ioki, K.

2001-01-01

The Full Scale Sector Model Project, which was initiated in 1995 as one of the Seven Large Projects for ITER R and D, has been continued with the joint effort of the ITER Joint Central Team and the Japanese, Russian Federation and United States Home Teams. The fabrication of a full scale 18 deg. toroidal sector, which is composed of two 9 deg. sectors spliced at the port centre, was successfully completed in September 1997 with a dimensional accuracy of ±3 mm for the total height and total width. Both sectors were shipped to the test site at the Japan Atomic Energy Research Institute and the integration test of the sectors was begun in October 1997. The integration test involves the adjustment of field joints, automatic narrow gap tungsten inert gas welding of field joints with splice plates and inspection of the joints by ultrasonic testing, as required for the initial assembly of the ITER vacuum vessel. This first demonstration of field joint welding and the performance test of the mechanical characteristics were completed in May 1998, and all the results obtained have satisfied the ITER design. In addition to these tests, integration with the midplane port extension fabricated by the Russian Home Team by using a fully remotized welding and cutting system developed by the US Home Team was completed in March 2000. The article describes the progress, achievements and latest status of the R and D activities for the ITER vacuum vessel. (author)

Design and Structural Analysis for the Vacuum Vessel of Superconducting Tokamak JT-60SC

International Nuclear Information System (INIS)

Kudo, Y.; Sakurai, S.; Masaki, K.; Urata, K.; Sasajima, T.; Matsukawa, M.; Sakasai, A.; Ishida, S.

2003-01-01

A modification of the JT-60 is planned to be a superconducting tokamak (JT-60SC) in order to establish steady-state operation of high beta plasma for 100 s, and to ensure the applicability of ferritic steel as a reduced activation material for reactor relevant break-even class plasmas. This paper describes the detailed design of the vacuum vessel, which has a unique structure for cost effective manufacturing, as well as structural analysis results for a feasibility study

Temperature distributions in a Tokamak vacuum vessel of fusion reactor after the loss-of-vacuum-events occurred

International Nuclear Information System (INIS)

Takase, K.; Kunugi, T.; Shibata, M.; Seki, Y.

1998-01-01

If a loss-of-vacuum-event (LOVA) occurred in a fusion reactor, buoyancy-driven exchange flows would occur at breaches of a vacuum vessel (VV) due to the temperature difference between the inside and outside of the VV. The exchange flows may bring mixtures of activated materials and tritium in the VV to the outside through the breaches, and remove decay heat from the plasma-facing components of the VV. Therefore, the LOVA experiments were carried out under the condition that one or two breaches was opened and that the VV was heated to a maximum 200 C, using a small-scaled LOVA experimental apparatus. Air and helium gas were provided as working fluids. Fluid and wall temperature distributions in the VV were measured and the flow patterns in the VV were estimated by using these temperature distributions. It was found that: (1) the exchange mass in the VV depended on the breach positions; (2) the exchange flow at the single breach case became a counter-current flow when the breach was at the roof of the VV and a stratified flow when it was at the side wall; (3) and that at the double breach case, a one-way flow between two breaches was formed. (orig.)

Modeling and measurement of the motion of the DIII-D vacuum vessel during vertical instabilities

International Nuclear Information System (INIS)

Reis, E.; Blevins, R.D.; Jensen, T.H.; Luxon, J.L.; Petersen, P.I.; Strait, E.J.

1991-11-01

The motions of the D3-D vacuum vessel during vertical instabilities of elongated plasmas have been measured and studied over the past five years. The currents flowing in the vessel wall and the plasma scrapeoff layer were also measured and correlated to a physics model. These results provide a time history load distribution on the vessel which were input to a dynamic analysis for correlation to the measured motions. The structural model of the vessel using the loads developed from the measured vessel currents showed that the calculated displacement history correlated well with the measured values. The dynamic analysis provides a good estimate of the stresses and the maximum allowable deflection of the vessel. In addition, the vessel motions produce acoustic emissions at 21 Hertz that are sufficiently loud to be felt as well as heard by the D3-D operators. Time history measurements of the sounds were correlated to the vessel displacements. An analytical model of an oscillating sphere provided a reasonable correlation to the amplitude of the measured sounds. The correlation of the theoretical and measured vessel currents, the dynamic measurements and analysis, and the acoustic measurements and analysis show that: (1) The physics model can predict vessel forces for selected values of plasma resistivity. The model also predicts poloidal and toroidal wall currents which agree with measured values; (2) The force-time history from the above model, used in conjunction with an axisymmetric structural model of the vessel, predicts vessel motions which agree well with measured values; (3) The above results, input to a simple acoustic model predicts the magnitude of sounds emitted from the vessel during disruptions which agree with acoustic measurements; (4) Correlation of measured vessel motions with structural analysis shows that a maximum vertical motion of the vessel up to 0.24 in will not overstress the vessel or its supports. 11 refs., 10 figs., 1 tab

Proceedings of the SLAC/KEK ATF lattice workshop

International Nuclear Information System (INIS)

Urakawa, Junji

1993-04-01

The SLAC/KEK ATF Lattice Workshop was held on December 8-11, 1992 at KEK, National Laboratory for High Energy Physics. The purpose of this workshop is to critically review the ATF lattice design for any possible improvements, and also to bring SLAC colleagues up to date on recent progress at KEK. At KEK studies on intense multi-bunch beam acceleration and emittance reduction have been actively pursued, evolving into the ATF project since 1990. In 1991 we have launched a large scale reconstruction of the experimental hall. This is to build the shielded housing for the 1.54 GeV injector linac and the test damping ring. Our plan is to begin construction of the linac in March 1993. Some results from the discussions during the Workshop have been already incorporated in the revised ATF lattice design. (J.P.N.)

Critical issues of the structural integrity of the ITER-FEAT vacuum vessel

International Nuclear Information System (INIS)

Sannazzaro, G.; Barabaschi, P.; Elio, F.; Ioki, K.; Miki, N.; Onozuka, M.; Utin, Y.; Verrecchia, M.; Yoshimura, H.

2001-01-01

In the ITER-FEAT, the most severe loading conditions for the VV are the toroidal field coil fast discharge (TFCFD) and its load combination with electromagnetic loads due to a plasma vertical instability, which cause high compressive stresses in the VV inboard wall and increase the risk of buckling. Detailed analyses need to be performed to assess the stress level at the geometrical discontinuities and where concentrated loads are applied. The nuclear heating and the presence of gaps between the blanket modules cause concentrated nuclear heat loads. This paper describes the major structural issues of the ITER vacuum vessel (VV), and summarises the preliminary results of structural analyses

Critical issues of the structural integrity of the ITER-FEAT vacuum vessel

Energy Technology Data Exchange (ETDEWEB)

Sannazzaro, G. E-mail: sannazg@itereu.de; Barabaschi, P.; Elio, F.; Ioki, K.; Miki, N.; Onozuka, M.; Utin, Y.; Verrecchia, M.; Yoshimura, H

2001-11-01

In the ITER-FEAT, the most severe loading conditions for the VV are the toroidal field coil fast discharge (TFCFD) and its load combination with electromagnetic loads due to a plasma vertical instability, which cause high compressive stresses in the VV inboard wall and increase the risk of buckling. Detailed analyses need to be performed to assess the stress level at the geometrical discontinuities and where concentrated loads are applied. The nuclear heating and the presence of gaps between the blanket modules cause concentrated nuclear heat loads. This paper describes the major structural issues of the ITER vacuum vessel (VV), and summarises the preliminary results of structural analyses.

Influence of INCONEL 625 composition on the activation characteristics of the vacuum vessel of experimental fusion tokamaks

International Nuclear Information System (INIS)

Cambi, G.; Cepraga, D.G.; Boeriu, S.; Maganzani, I.

1995-01-01

The radioactive inventory, the decay heat and the contact dose rate of permanent components such as the vacuum vessel of two experimental fusion tokamaks, the compact IGNITOR-ULT and the ITER-EDA fusion machines, are evaluated by using the ENEA-Bologna integrated methodology. The vacuum vessel material considered is the INCONEL 625. The neutron flux is calculated using the VITAMIN-C 171-group library, based on EFF-2 data and the 1-D transport code XSDRNPM in the S 8 -P 3 approximation. The ANITA-2 code, using updated cross sections and decay data libraries based on EAF-3 and IRDF90 evaluation files is used for activation calculations. The fusion neutron source has been normalised to a neutron first wall load of 2 MW/m 2 and 1 MW/m 2 for IGNITOR-ULT and ITER, respectively. The material irradiation have been described by multistep time histories, resulting in the designed total fluence. Variations in the composition of INCONEL 625 have been assessed and their impact on the activation characteristics are discussed, also from the point of view of waste disposal. (orig.)

Design and R and D for the ITER vacuum vessel

International Nuclear Information System (INIS)

Ioki, K.; Johnson, G.; Onozuka, M.; Sannazzaro, G.; Utin, Y.; Iizuka, T.; Parker, R.; Koizumi, K.; Kuzmin, E.; Maisonnier, D.; Nelson, B.

1998-01-01

The current design and key R and D results for the Vacuum Vessel (VV) for the International Thermonuclear Experimental Reactor (ITER) are presented. During the past two years the basic VV design has remained unchanged. Additional details have been defined in key areas and recent R and D results have indicated where further improvements can be made. R and D results have also confirmed the feasibility of important aspects of the design such as limiting weld distortions to acceptable levels and achieving required tolerances with a large welded structure. Recent design progress includes the development of a structural design strategy for the VV, modification of the inboard structure, employment of ferromagnetic material between the VV shells, and confirmation of the cooling characteristics for the VV. This report presents the current design and how it has been affected by R and D results. (authors)

Design and R and D for the ITER vacuum vessel

Energy Technology Data Exchange (ETDEWEB)

Ioki, K.; Johnson, G.; Onozuka, M.; Sannazzaro, G.; Utin, Y.; Iizuka, T.; Parker, R. [ITER Joint Work Site, Garching (Germany); Koizumi, K. [Japan Atomic Energy Research Inst., Naka (Japan); Kuzmin, E. [Efremov Insitute, Saint Petersburg (Russian Federation); Maisonnier, D. [NET Team, Garching (Germany); Nelson, B. [Oak Ridge National Lab., TN (United States)

1998-07-01

The current design and key R and D results for the Vacuum Vessel (VV) for the International Thermonuclear Experimental Reactor (ITER) are presented. During the past two years the basic VV design has remained unchanged. Additional details have been defined in key areas and recent R and D results have indicated where further improvements can be made. R and D results have also confirmed the feasibility of important aspects of the design such as limiting weld distortions to acceptable levels and achieving required tolerances with a large welded structure. Recent design progress includes the development of a structural design strategy for the VV, modification of the inboard structure, employment of ferromagnetic material between the VV shells, and confirmation of the cooling characteristics for the VV. This report presents the current design and how it has been affected by R and D results. (authors)

The response of the prostate to circulating cholesterol: activating transcription factor 3 (ATF3 as a prominent node in a cholesterol-sensing network.

Directory of Open Access Journals (Sweden)

Jayoung Kim

Full Text Available Elevated circulating cholesterol is a systemic risk factor for cardiovascular disease and metabolic syndrome, however the manner in which the normal prostate responds to variations in cholesterol levels is poorly understood. In this study we addressed the molecular and cellular effects of elevated and suppressed levels of circulating cholesterol on the normal prostate. Integrated bioinformatic analysis was performed using DNA microarray data from two experimental formats: (1 ventral prostate from male mice with chronically elevated circulating cholesterol and (2 human prostate cells exposed acutely to cholesterol depletion. A cholesterol-sensitive gene expression network was constructed from these data and the transcription factor ATF3 was identified as a prominent node in the network. Validation experiments confirmed that elevated cholesterol reduced ATF3 expression and enhanced proliferation of prostate cells, while cholesterol depletion increased ATF3 levels and inhibited proliferation. Cholesterol reduction in vivo alleviated dense lymphomononuclear infiltrates in the periprostatic adipose tissue, which were closely associated with nerve tracts and blood vessels. These findings open new perspectives on the role of cholesterol in prostate health, and provide a novel role for ATF3, and associated proteins within a large signaling network, as a cholesterol-sensing mechanism.

Design of the ZTH vacuum liner

International Nuclear Information System (INIS)

Prince, P.P.; Dike, R.S.

1987-01-01

The current status of the ZTh vacuum liner design is covered by this report. ZTH will be the first experiment to be installed in the CPRF (Confinement Physics Research Facility) at the Los Alamos National Laboratory and is scheduled to be operational at the rated current of 4 MA in 1992. The vacuum vessel has a 2.4m major radius and a 40 cm minor radius. Operating parameters which drive the vacuum vessel mechanical design include a 300 C bakeout temperature, an armour support system capable of withstanding 25 kV, a high toroidal resistance, 1250 kPa magnetic loading, a 10 minute cycle time, and high positional accuracy with respect to the conducting shell. The vacuum vessel design features which satisfy the operating parameters are defined

Weld distortion prediction of the ITER Vacuum Vessel using Finite Element simulations

Energy Technology Data Exchange (ETDEWEB)

Caixas, Joan, E-mail: joan.caixas@f4e.europa.eu [F4E, c/ Josep Pla, n.2, Torres Diagonal Litoral, Edificio B3, E-08019 Barcelona (Spain); Guirao, Julio [Numerical Analysis Technologies, S. L., Marqués de San Esteban 52, Entlo, 33209 Gijon (Spain); Bayon, Angel; Jones, Lawrence; Arbogast, Jean François [F4E, c/ Josep Pla, n.2, Torres Diagonal Litoral, Edificio B3, E-08019 Barcelona (Spain); Barbensi, Andrea [Ansaldo Nucleare, Corso F.M. Perrone, 25, I-16152 Genoa (Italy); Dans, Andres [F4E, c/ Josep Pla, n.2, Torres Diagonal Litoral, Edificio B3, E-08019 Barcelona (Spain); Facca, Aldo [Mangiarotti, Pannellia di Sedegliano, I-33039 Sedegliano (UD) (Italy); Fernandez, Elena; Fernández, José [F4E, c/ Josep Pla, n.2, Torres Diagonal Litoral, Edificio B3, E-08019 Barcelona (Spain); Iglesias, Silvia [Numerical Analysis Technologies, S. L., Marqués de San Esteban 52, Entlo, 33209 Gijon (Spain); Jimenez, Marc; Jucker, Philippe; Micó, Gonzalo [F4E, c/ Josep Pla, n.2, Torres Diagonal Litoral, Edificio B3, E-08019 Barcelona (Spain); Ordieres, Javier [Numerical Analysis Technologies, S. L., Marqués de San Esteban 52, Entlo, 33209 Gijon (Spain); Pacheco, Jose Miguel [F4E, c/ Josep Pla, n.2, Torres Diagonal Litoral, Edificio B3, E-08019 Barcelona (Spain); Paoletti, Roberto [Walter Tosto, Via Erasmo Piaggio, 72, I-66100 Chieti Scalo (Italy); Sanguinetti, Gian Paolo [Ansaldo Nucleare, Corso F.M. Perrone, 25, I-16152 Genoa (Italy); Stamos, Vassilis [F4E, c/ Josep Pla, n.2, Torres Diagonal Litoral, Edificio B3, E-08019 Barcelona (Spain); Tacconelli, Massimiliano [Walter Tosto, Via Erasmo Piaggio, 72, I-66100 Chieti Scalo (Italy)

2013-10-15

Highlights: ► Computational simulations of the weld processes can rapidly assess different sequences. ► Prediction of welding distortion to optimize the manufacturing sequence. ► Accurate shape prediction after each manufacture phase allows to generate modified procedures and pre-compensate distortions. ► The simulation methodology is improved using condensed computation techniques with ANSYS in order to reduce computation resources. ► For each welding process, the models are calibrated with the results of coupons and mock-ups. -- Abstract: The as-welded surfaces of the ITER Vacuum Vessel sectors need to be within a very tight tolerance, without a full-scale prototype. In order to predict welding distortion and optimize the manufacturing sequence, the industrial contract includes extensive computational simulations of the weld processes which can rapidly assess different sequences. The accurate shape prediction, after each manufacturing phase, enables actual distortions to be compared with the welding simulations to generate modified procedures and pre-compensate distortions. While previous mock-ups used heavy welded-on jigs to try to restrain the distortions, this method allows the use of lightweight jigs and yields important cost and rework savings. In order to enable the optimization of different alternative welding sequences, the simulation methodology is improved using condensed computation techniques with ANSYS in order to reduce computational resources. For each welding process, the models are calibrated with the results of coupons and mock-ups. The calibration is used to construct representative models of each segment and sector. This paper describes the application to the construction of the Vacuum Vessel sector of the enhanced simulation methodology with condensed Finite Element computation techniques and results of the calibration on several test pieces for different types of welds.

Weld distortion prediction of the ITER Vacuum Vessel using Finite Element simulations

International Nuclear Information System (INIS)

Caixas, Joan; Guirao, Julio; Bayon, Angel; Jones, Lawrence; Arbogast, Jean François; Barbensi, Andrea; Dans, Andres; Facca, Aldo; Fernandez, Elena; Fernández, José; Iglesias, Silvia; Jimenez, Marc; Jucker, Philippe; Micó, Gonzalo; Ordieres, Javier; Pacheco, Jose Miguel; Paoletti, Roberto; Sanguinetti, Gian Paolo; Stamos, Vassilis; Tacconelli, Massimiliano

2013-01-01

Highlights: ► Computational simulations of the weld processes can rapidly assess different sequences. ► Prediction of welding distortion to optimize the manufacturing sequence. ► Accurate shape prediction after each manufacture phase allows to generate modified procedures and pre-compensate distortions. ► The simulation methodology is improved using condensed computation techniques with ANSYS in order to reduce computation resources. ► For each welding process, the models are calibrated with the results of coupons and mock-ups. -- Abstract: The as-welded surfaces of the ITER Vacuum Vessel sectors need to be within a very tight tolerance, without a full-scale prototype. In order to predict welding distortion and optimize the manufacturing sequence, the industrial contract includes extensive computational simulations of the weld processes which can rapidly assess different sequences. The accurate shape prediction, after each manufacturing phase, enables actual distortions to be compared with the welding simulations to generate modified procedures and pre-compensate distortions. While previous mock-ups used heavy welded-on jigs to try to restrain the distortions, this method allows the use of lightweight jigs and yields important cost and rework savings. In order to enable the optimization of different alternative welding sequences, the simulation methodology is improved using condensed computation techniques with ANSYS in order to reduce computational resources. For each welding process, the models are calibrated with the results of coupons and mock-ups. The calibration is used to construct representative models of each segment and sector. This paper describes the application to the construction of the Vacuum Vessel sector of the enhanced simulation methodology with condensed Finite Element computation techniques and results of the calibration on several test pieces for different types of welds

Vessel eddy current characteristics in SST-1 tokamak

Energy Technology Data Exchange (ETDEWEB)

Jana, Subrata; Pradhan, Subrata, E-mail: pradhan@ipr.res.in; Dhongde, Jasraj; Masand, Harish

2016-11-15

Highlights: • Eddy current distribution in the SST-1 vacuum vessel. • Circuit model analysis of eddy current. • A comparison of the field lines with and without the plasma column in identical conditions. • The influence of eddy current in magnetic NULL dynamics. - Abstract: Eddy current distribution in the vacuum vessel of the Steady state superconducting (SST-1) tokamak has been determined from the experimental data obtained using an array of internal voltage loops (flux loop) installed inside the vacuum vessel. A simple circuit model has been employed. The model takes into account the geometric and constructional features of SST-1 vacuum vessel. SST-1 vacuum vessel is a modified ‘D’ shaped vessel having major axis of 1.285 m and minor axis of 0.81 m and has been manufactured from non-magnetic stainless steel. The Plasma facing components installed inside the vacuum vessel are graphite blocks mounted on Copper Chromium Zirconium (CuCrZr) heat sink plates on inconel supports. During discharge of the central solenoid, eddy currents get generated in the vacuum vessel and passive supports on it. These eddy currents influence the early magnetic NULL dynamics and plasma break-down and start-up characteristics. The computed results obtained from the model have been benchmarked against experimental data obtained in large number of SST-1 plasma shots. The results are in good agreement. Once bench marked, the calculated eddy current based on flux loop signal and circuit equation model has been extended to the reconstruction of the overall B- field contours of SST-1 tokamak in the vessel region. A comparison of the field lines with and without the plasma column in identical conditions of the central solenoid and equilibrium field profiles has also been done with an aim to quantify the diagnostics responses in vacuum shots.

Assessment of the dynamic behaviours of the ITER Vacuum Vessel

Energy Technology Data Exchange (ETDEWEB)

Blocki, J., E-mail: jacek.blocki@f4e.europa.eu [Fusion for Energy, Josep Pla 2, Torres Diagonal Litoral B3, 08019 Barcelona (Spain); Combescure, D. [Fusion for Energy, Josep Pla 2, Torres Diagonal Litoral B3, 08019 Barcelona (Spain); Mazzone, G. [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul Lez Durance (France)

2013-10-15

Highlights: ► The cyclic symmetry structure with special boundary conditions has been analyzed. ► Results based on the FE solid model and on the FE shell model have been compared. ► The effect of the missing mass contained has been checked. -- Abstract: The dynamic behaviour of the ITER Vacuum Vessel (VV) under seismic loads will be assessed by carrying out the modal analysis and then by applying the response spectrum method which describes earthquake motions. The effect of the missing mass is included in this last analysis. Numerical results are based on two different Finite Element (FE) models and on three different methods by which natural frequencies and mode shapes are defined. It means, it is applied the cyclic symmetry method, the component mode synthesis method and the 360° FE model of the VV. Comparisons between obtained results for the different models and methods are presented.

Design of parallel intersector weld/cut robot for machining processes in ITER vacuum vessel

International Nuclear Information System (INIS)

Wu Huapeng; Handroos, Heikki; Kovanen, Janne; Rouvinen, Asko; Hannukainen, Petri; Saira, Tanja; Jones, Lawrence

2003-01-01

This paper presents a new parallel robot Penta-WH, which has five degrees of freedom driven by hydraulic cylinders. The manipulator has a large, singularity-free workspace and high stiffness and it acts as a transport device for welding, machining and inspection end-effectors inside the ITER vacuum vessel. The presented kinematic structure of a parallel robot is particularly suitable for the ITER environment. Analysis of the machining process for ITER, such as the machining methods and forces are given, and the kinematic analyses, such as workspace and force capacity are discussed

R and D status of the ATF damping ring

International Nuclear Information System (INIS)

Urakawa, Junji

1994-01-01

The KEK accelerator test facility (ATF) is under construction. This paper gives the status of the design studies, the various R and D works and the construction for the damping ring of the ATF. (author)

CAVITY BEAM POSITION MONITOR SYSTEM FOR ATF2

CERN Document Server

Boogert, S T; Cullinan, F; Joshi, N; Lyapin, A; Aryshev, A; Honda, Y; Naito, T; Terunuma, N; Urakara, J; Heo, A; Kim, E-S; Kim, Y I; McCormick, D; Frisch, J; Nelson, J; Smith, T; White, G R

2011-01-01

The Accelerator Test Facility 2 (ATF2) in KEK, Japan, is a prototype scaled demonstrator system for the final focus required for a future high energy lepton linear collider. The ATF2 beam-line is instrumented with a total of 41 high resolution C and S band resonant cavity beam position monitors (BPM) with associated mixer electronics and digitisers. In addition 4 high resolution BPMs have been recently installed at the interaction point, we briefly describe the first operational experience of these cavities in the ATF2 beam-line. The current status of the overall BPM system is also described, with a focus on operational techniques and performance.

Development and quality assessments of commercial heat production of ATF FeCrAl tubes

Energy Technology Data Exchange (ETDEWEB)

Yamamoto, Yukinori [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

2015-09-01

Development and quality assessment of the 2^nd generation ATF FeCrAl tube production with commercial manufacturers were conducted. The manufacturing partners include Sophisticated Alloys, Inc. (SAI), Butler, PA for FeCrAl alloy casting via vacuum induction melting, Oak Ridge National Laboratory (ORNL) for extrusion process to prepare the master bars/tubes to be tube-drawn, and Rhenium Alloys, Inc. (RAI), North Ridgeville, OH, for tube-drawing process. The masters bars have also been provided to Los Alamos National Laboratory (LANL) who works with Century Tubes, Inc., (CTI), San Diego, CA, as parallel tube production effort under the current program.

ATF [Advanced Toroidal Facility]-2 studies

International Nuclear Information System (INIS)

Lyon, J.F.; Carreras, B.A.; Dominguez, N.

1989-10-01

Design studies for a low-aspect-ratio, large next-generation stellarator, ATF-II, with high-current-density, high-field, stable NbTi/Cu helical windings are described. The design parameters are an average plasma radius of 0.52 m, a major radius of 2 m, and a field on axis of 4-5 T, with 10 to 15 MW of heating power. Such a device would be comparable in scope to other next-generation stellarators but would have roughly the same aspect ratio as the tokamaks without, however, the need for current drive to sustain steady-state operation. A number of low-aspect-ratio physics issues need to be addressed in the design of ATF-II, primarily compromises between high-beta capability and good confinement properties. A six-field-period Compact Torsatron is chosen as a reference design for ATF-II, and its main features and performance predictions are discussed. An integrated (beta capability and confinement) optimization approach and optimization of superconducting windings are also discussed. 36 refs., 13 figs., 2 tabs

Bake-Out Mobile Controls for Large Vacuum Systems

CERN Document Server

Blanchard, S; Gomes, P; Pereira, H; Kopylov, L; Merker, S; Mikheev, M

2014-01-01

Large vacuum systems at CERN (Large Hadron Collider - LHC, Low Energy Ion Rings - LEIR...) require bake-out to achieve ultra-high vacuum specifications. The bake-out cycle is used to decrease the outgassing rate of the vacuum vessel and to activate the Non-Evaporable Getter (NEG) thin film. Bake-out control is a Proportional-Integral-Derivative (PID) regulation with complex recipes, interlocks and troubleshooting management and remote control. It is based on mobile Programmable Logic Controller (PLC) cabinets, fieldbus network and Supervisory Control and Data Acquisition (SCADA) application. The CERN vacuum installations include more than 7 km of baked vessels; using mobile cabinets reduces considerably the cost of the control system. The cabinets are installed close to the vacuum vessels during the time of the bake-out cycle. Mobile cabinets can be used in any of the CERN vacuum facilities. Remote control is provided through a fieldbus network and a SCADA application

Bolted Ribs Analysis for the ITER Vacuum Vessel using Finite Element Submodelling Techniques

Energy Technology Data Exchange (ETDEWEB)

Zarzalejos, José María, E-mail: jose.zarzalejos@ext.f4e.europa.eu [External at F4E, c/Josep Pla, n.2, Torres Diagonal Litoral, Edificio B3, E-08019, Barcelona (Spain); Fernández, Elena; Caixas, Joan; Bayón, Angel [F4E, c/Josep Pla, n.2, Torres Diagonal Litoral, Edificio B3, E-08019, Barcelona (Spain); Polo, Joaquín [Iberdrola Ingeniería y Construcción, Avenida de Manoteras 20, 28050 Madrid (Spain); Guirao, Julio [Numerical Analysis Technologies, S L., Marqués de San Esteban 52, Entlo, 33209 Gijon (Spain); García Cid, Javier [Iberdrola Ingeniería y Construcción, Avenida de Manoteras 20, 28050 Madrid (Spain); Rodríguez, Eduardo [Mechanical Engineering Department EPSIG, University of Oviedo, Gijon (Spain)

2014-10-15

Highlights: • The ITER Vacuum Vessel Bolted Ribs assemblies are modelled using Finite Elements. • Finite Element submodelling techniques are used. • Stress results are obtained for all the assemblies and a post-processing is performed. • All the elements of the assemblies are compliant with the regulatory provisions. • Submodelling is a time-efficient solution to verify the structural integrity of this type of structures. - Abstract: The ITER Vacuum Vessel (VV) primary function is to enclose the plasmas produced by the ITER Tokamak. Since it acts as the first radiological barrier of the plasma, it is classified as a class 2 welded box structure, according to RCC-MR 2007. The VV is made of an inner and an outer D-shape, 60 mm-thick double shell connected through thick massive bars (housings) and toroidal and poloidal structural stiffening ribs. In order to provide neutronic shielding to the ex-vessel components, the space between shells is filled with borated steel plates, called In-Wall Shielding (IWS) blocks, and water. In general, these blocks are connected to the IWS ribs which are connected to adjacent housings. The development of a Finite Element model of the ITER VV including all its components in detail is unaffordable from the computational point of view due to the large number of degrees of freedom it would require. This limitation can be overcome by using submodelling techniques to simulate the behaviour of the bolted ribs assemblies. Submodelling is a Finite Element technique which allows getting more accurate results in a given region of a coarse model by generating an independent, finer model of the region under study. In this paper, the methodology and several simulations of the VV bolted ribs assemblies using submodelling techniques are presented. A stress assessment has been performed for the elements involved in the assembly considering possible types of failure and including stress classification and categorization techniques to analyse

Manufacturing, assembly and tests of SPIDER Vacuum Vessel to develop and test a prototype of ITER neutral beam ion source

Energy Technology Data Exchange (ETDEWEB)

Zaccaria, Pierluigi, E-mail: pierluigi.zaccaria@igi.cnr.it [Consorzio RFX (CNR, ENEA, INFN, Università di Padova, Acciaierie Venete S.p.A.), Padova (Italy); Valente, Matteo; Rigato, Wladi; Dal Bello, Samuele; Marcuzzi, Diego; Agostini, Fabio Degli; Rossetto, Federico; Tollin, Marco [Consorzio RFX (CNR, ENEA, INFN, Università di Padova, Acciaierie Venete S.p.A.), Padova (Italy); Masiello, Antonio [Fusion for Energy F4E, Barcelona (Spain); Corniani, Giorgio; Badalocchi, Matteo; Bettero, Riccardo; Rizzetto, Dario [Ettore Zanon S.p.A., Schio (VI) (Italy)

2015-10-15

Highlights: • The SPIDER experiment aims to qualify and optimize the ion source for ITER injectors. • The large SPIDER Vacuum Vessel was built and it is under testing at the supplier. • The main working and assembly steps for production are presented in the paper. - Abstract: The SPIDER experiment (Source for the Production of Ions of Deuterium Extracted from an RF plasma) aims to qualify and optimize the full size prototype of the negative ion source foreseen for MITICA (full size ITER injector prototype) and the ITER Heating and Current Drive Injectors. Both SPIDER and MITICA experiments are presently under construction at Consorzio RFX in Padova (I), with the financial support from IO (ITER Organization), Fusion for Energy, Italian research institutions and contributions from Japan and India Domestic Agencies. The vacuum vessel hosting the SPIDER in-vessel components (Beam Source and calorimeters) has been manufactured, assembled and tested during the last two years 2013–2014. The cylindrical vessel, about 6 m long and 4 m in diameter, is composed of two cylindrical modules and two torispherical lids at the ends. All the parts are made by AISI 304 L stainless steel. The possibility of opening/closing the vessel for monitoring, maintenance or modifications of internal components is guaranteed by bolted junctions and suitable movable support structures running on rails fixed to the building floor. A large number of ports, about one hundred, are present on the vessel walls for diagnostic and service purposes. The main working steps for construction and specific technological issues encountered and solved for production are presented in the paper. Assembly sequences and tests on site are furthermore described in detail, highlighting all the criteria and requirements for correct positioning and testing of performances.

Manufacturing, assembly and tests of SPIDER Vacuum Vessel to develop and test a prototype of ITER neutral beam ion source

International Nuclear Information System (INIS)

Zaccaria, Pierluigi; Valente, Matteo; Rigato, Wladi; Dal Bello, Samuele; Marcuzzi, Diego; Agostini, Fabio Degli; Rossetto, Federico; Tollin, Marco; Masiello, Antonio; Corniani, Giorgio; Badalocchi, Matteo; Bettero, Riccardo; Rizzetto, Dario

2015-01-01

Highlights: • The SPIDER experiment aims to qualify and optimize the ion source for ITER injectors. • The large SPIDER Vacuum Vessel was built and it is under testing at the supplier. • The main working and assembly steps for production are presented in the paper. - Abstract: The SPIDER experiment (Source for the Production of Ions of Deuterium Extracted from an RF plasma) aims to qualify and optimize the full size prototype of the negative ion source foreseen for MITICA (full size ITER injector prototype) and the ITER Heating and Current Drive Injectors. Both SPIDER and MITICA experiments are presently under construction at Consorzio RFX in Padova (I), with the financial support from IO (ITER Organization), Fusion for Energy, Italian research institutions and contributions from Japan and India Domestic Agencies. The vacuum vessel hosting the SPIDER in-vessel components (Beam Source and calorimeters) has been manufactured, assembled and tested during the last two years 2013–2014. The cylindrical vessel, about 6 m long and 4 m in diameter, is composed of two cylindrical modules and two torispherical lids at the ends. All the parts are made by AISI 304 L stainless steel. The possibility of opening/closing the vessel for monitoring, maintenance or modifications of internal components is guaranteed by bolted junctions and suitable movable support structures running on rails fixed to the building floor. A large number of ports, about one hundred, are present on the vessel walls for diagnostic and service purposes. The main working steps for construction and specific technological issues encountered and solved for production are presented in the paper. Assembly sequences and tests on site are furthermore described in detail, highlighting all the criteria and requirements for correct positioning and testing of performances.

ATF4 is involved in the regulation of simulated microgravity induced integrated stress response

Science.gov (United States)

Li, Yingxian; Li, Qi; Wang, Xiaogang; Sun, Qiao; Wan, Yumin; Li, Yinghui; Bai, Yanqiang

Objective: Many important metabolic and signaling pathways have been identified as being affected by microgravity, thereby altering cellular functions such as proliferation, differentiation, maturation and cell survival. It has been demonstrated that microgravity could induce all kinds of stress response such as endoplasmic reticulum stress and oxidative stress et al. ATF4 belongs to the ATF/CREB family of basic region leucine zipper transcription factors. ATF4 is induced by stress signals including anoxia/hypoxia, ER stress, amino acid deprivation and oxidative stress. ATF4 regulates the expression of genes involved in oxidative stress, amino acid synthesis, differentiation, metastasis and angiogenesis. The aim of this study was to examine the changes of ATF4 under microgravity, and to investigate the role of ATF4 in microgravity induced stress. MethodsMEF cells were cultured in clinostat to simulate microgravity. Reverse transcription polymerase chain reaction (RT-PCR) and western blotting were used to examine mRNA and protein levels of ATF4 expression under simulated microgravity in MEF cells. ROS levels were measured with the use of the fluorescent signal H2DCF-DA. GFP-XBP1 stably transfected cell lines was used to detect the extent of ER stress under microgravity by the intensity of GFP. Dual luciferase reporter assay was used to detect the activity of ATF4. Co-immunoprecipitation was performed to analyze protein interaction. Results: ATF4 protein levels in MEF cells increased under simulated microgravity. However, ATF4 mRNA levels were consistent. XBP1 splicing can be induced due to ER stress caused by simulated microgravity. At the same time, ROS levels were also increased. Increased ATF4 could promote the expression of CHOP, which is responsible for cell apoptosis. ATF4 also play an important role in cellular anti-oxidant stress. In ATF4 -/-MEF cells, the ROS levels after H2O2 treatment were obviously higher than that of wild type cells. HDAC4 was

Design and high order optimization of the ATF2 lattices

CERN Document Server

Marin, E; Woodley, M; Kubo, K; Okugi, T; Tauchi, T; Urakawa, J; Tomas, R

2013-01-01

The next generation of future linear colliders (LC) demands nano-meter beam sizes at the interaction point (IP) in order to reach the required luminosity. The final focus system (FFS) of a LC is meant to deliver such small beam sizes. The Accelerator Test Facility (ATF) aims to test the feasibility of the new local chromaticity correction scheme which the future LCs are based on. To this end the ATF2 nominal and ultra-low beta* lattices are design to vertically focus the beam at the IP to 37nm and 23nm, respectively if error-free lattices are considered. However simulations show that the measured field errors of the ATF2 magnets preclude to reach the mentioned spot sizes. This paper describes the optimization of high order aberrations of the ATF2 lattices in order to minimize the detrimental effect of the measured multipole components for both ATF2 lattices. Specifically three solutions are studied, the replacement of the last focusing quadrupole (QF1FF), insertion of octupole magnets and optics modification....

Simulation of LLCB TBM in-vessel first wall coolant break into ITER vacuum vessel by using RELAP/MOD3.4

International Nuclear Information System (INIS)

Tony Sandeep, K.; Chaudhari, Vilas; Rajendra Kumar, E.; Dutta, Anu; Singh, R.K.

2013-06-01

To prove Test Blanket Module (TBM) safety in International Thermonuclear Experimental Reactor (ITER), various accident scenarios are postulated . One of the postulated initiating events to be analysed is TBM First wall (FW) coolant leak in ITER Vacuum vessel (VV). This accident has been classified as a reference event for the TBM (probability of occurrence >1 E -06 /a). The postulated accident occurs as a result of small leak of TBM FW helium into ITER vacuum vessel (VV), caused by the TBM weld failure. The ingress of this TBM FW helium into ITER plasma induces intense plasma disruption that deposits 1.8 MJ/m 2 of plasma stored thermal energy onto the TBM FW over a period of 1 sec in duration (assumption). Runaway electrons in this process are lost from plasma current channel and cause multiple TBM and ITER FW cooling tube failures within 10 cm torriodal strip. The size of the break is identified as double ended rupture of all coolant channels within this strip around the reactor. For LLCB TBM this represents failure of 4 FW channels. The size of ITER FW break is 0.02 m 2 . Consequently, a simultaneous blow down of TBM FW helium and ITER FW water occurs, injecting helium and water into VV. This pressurisation causes the activation of VV pressure suppressions system and ingress of water into VV. This pressurisation causes the VV pressure suppressions system (VVPSS) to open in an attempt to contain the pressure below the safety limit of 0.2 MPa. This report is intended to do the above accident analysis and assessment of active components of TBM using RELAP code and hence prove its safety in ITER environment. (author)

Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription.

Science.gov (United States)

Wang, Weiguang; Lian, Na; Li, Lingzhen; Moss, Heather E; Wang, Weixi; Perrien, Daniel S; Elefteriou, Florent; Yang, Xiangli

2009-12-01

Activating transcription factor 4 (Atf4) is a leucine-zipper-containing protein of the cAMP response element-binding protein (CREB) family. Ablation of Atf4 (Atf4(-/-)) in mice leads to severe skeletal defects, including delayed ossification and low bone mass, short stature and short limbs. Atf4 is expressed in proliferative and prehypertrophic growth plate chondrocytes, suggesting an autonomous function of Atf4 in chondrocytes during endochondral ossification. In Atf4(-/-) growth plate, the typical columnar structure of proliferative chondrocytes is disturbed. The proliferative zone is shortened, whereas the hypertrophic zone is transiently expanded. The expression of Indian hedgehog (Ihh) is markedly decreased, whereas the expression of other chondrocyte marker genes, such as type II collagen (Col2a1), PTH/PTHrP receptor (Pth1r) and type X collagen (Col10a1), is normal. Furthermore, forced expression of Atf4 in chondrocytes induces endogenous Ihh mRNA, and Atf4 directly binds to the Ihh promoter and activates its transcription. Supporting these findings, reactivation of Hh signaling pharmacologically in mouse limb explants corrects the Atf4(-/-) chondrocyte proliferation and short limb phenotypes. This study thus identifies Atf4 as a novel transcriptional activator of Ihh in chondrocytes that paces longitudinal bone growth by controlling growth plate chondrocyte proliferation and differentiation.

Proposal to negotiate an amendment to an existing contract for the supply of additional vacuum vessels for the short-straight sections of the LHC

CERN Document Server

2005-01-01

This document concerns the proposal to negotiate an amendment to an existing contract for the supply of additional vacuum vessels for the short-straight sections of the LHC. For the reasons explained in this document, the Finance Committee is invited to approve an amendment to an existing contract with SLOVENSKE ENERGETICKE STROJARNE (SK) for the supply of 25 additional vacuum vessels for the short-straight sections for the LHC for an amount of 140 000 euros (216 999 Swiss francs), subject to revision for inflation, bringing the total to a maximum amount of 6 176 855 euros (9 574 097 Swiss francs), subject to revision for inflation. The rate of exchange used is that stipulated in the tender.

Status of the EU domestic agency electromagnetic analyses of ITER vacuum vessel and blanket modules

Energy Technology Data Exchange (ETDEWEB)

Testoni, P., E-mail: pietro.testoni@f4e.europa.eu [Fusion for Energy, Josep Plá n. 2, Torres Diagonal Litoral B3, 08019 Barcelona (Spain); Albanese, R. [Association Euratom/ENEA/CREATE, DIEL, Università Federico II di Napoli, Napoli 80125 (Italy); Lucca, F.; Roccella, M. [L.T. Calcoli S.a.S. Piazza Prinetti, 26/B, Merate, Lecco (Italy); Portone, A. [Fusion for Energy, Josep Plá n. 2, Torres Diagonal Litoral B3, 08019 Barcelona (Spain); Rubinacci, G. [Association Euratom/ENEA/CREATE, DIEL, Università Federico II di Napoli, Napoli 80125 (Italy); Ventre, S.; Villone, F. [Association Euratom/ENEA/CREATE, DAEIMI, Università di Cassino, Cassino 03043 (Italy)

2013-10-15

Highlights: Eddy and halo currents and corresponding Lorentz forces on the ITER vacuum vessel and blanket modules have been computed. VDEs and MDs belonging to cat III, II and I, and a magnet fast discharge have been simulated. The maximum vertical force in the VV (about 120 MN downwards) is experienced in VDE-DW-SLOW cat III. For the FW panel of blanket 18 the most demanding load case is the VDE downward cat III producing a radial torque of about 110 kNm. For the FW of blanket module 10 the most demanding load case is the VDE upward exp cat III producing a poloidal torque of about 130 kNm. -- Abstract: This paper presents the results of the electromagnetic analyses of the ITER vacuum vessel and blanket modules. A wide collection of electromagnetic transients has been simulated: VDEs and MDs belonging to cat III, II and I, and a magnet fast discharge. Eddy and halo currents and corresponding Lorentz forces have been computed using 3D solid FE models implemented in ANSYS and CARIDDI. The plasma equilibrium configurations (displacement and quench of the plasma current, toroidal flux variation due to the β drop and halo currents wetting the first wall) used as an input for the EM analyses have been supplied by the 2D axisymmetric code DINA. The paper describes in detail the methodology used for the analyses and the main results obtained.

Status of the EU domestic agency electromagnetic analyses of ITER vacuum vessel and blanket modules

International Nuclear Information System (INIS)

Testoni, P.; Albanese, R.; Lucca, F.; Roccella, M.; Portone, A.; Rubinacci, G.; Ventre, S.; Villone, F.

2013-01-01

Highlights: Eddy and halo currents and corresponding Lorentz forces on the ITER vacuum vessel and blanket modules have been computed. VDEs and MDs belonging to cat III, II and I, and a magnet fast discharge have been simulated. The maximum vertical force in the VV (about 120 MN downwards) is experienced in VDE-DW-SLOW cat III. For the FW panel of blanket 18 the most demanding load case is the VDE downward cat III producing a radial torque of about 110 kNm. For the FW of blanket module 10 the most demanding load case is the VDE upward exp cat III producing a poloidal torque of about 130 kNm. -- Abstract: This paper presents the results of the electromagnetic analyses of the ITER vacuum vessel and blanket modules. A wide collection of electromagnetic transients has been simulated: VDEs and MDs belonging to cat III, II and I, and a magnet fast discharge. Eddy and halo currents and corresponding Lorentz forces have been computed using 3D solid FE models implemented in ANSYS and CARIDDI. The plasma equilibrium configurations (displacement and quench of the plasma current, toroidal flux variation due to the β drop and halo currents wetting the first wall) used as an input for the EM analyses have been supplied by the 2D axisymmetric code DINA. The paper describes in detail the methodology used for the analyses and the main results obtained

Design and fabrication methods of FW/blanket, divertor and vacuum vessel for ITER

Science.gov (United States)

Ioki, K.; Barabash, V.; Cardella, A.; Elio, F.; Ibbott, C.; Janeschitz, G.; Johnson, G.; Kalinin, G.; Miki, N.; Onozuka, M.; Sannazzaro, G.; Tivey, R.; Utin, Y.; Yamada, M.

2000-12-01

Design has progressed on the vacuum vessel, FW/blanket and Divertor for the Reduced Technical Objective/Reduced Cost (RTO/RC) ITER. The basic functions and structures are the same as for the 1998 ITER design [K. Ioki et al., J. Nucl. Mater. 258-263 (1998) 74]. Design and fabrication methods of the components have been improved to achieve ˜50% reduction of the construction cost. Detailed blanket module designs with flat separable FW panels have been developed to reduce the fabrication cost and the future radioactive waste. Most of the R&D performed so far during the Engineering Design Activities (EDAs) are still applicable. Further cost reduction methods are also being investigated and additional R&D is being performed.

Structural analysis of support structure for ITER vacuum vessel

International Nuclear Information System (INIS)

Takeda, Nobukazu; Ohmori, Junji; Nakahira, Masataka

2004-12-01

ITER vacuum vessel (VV) is a safety component confining radioactive materials such as tritium and activated dust. An independent VV support structure with multiple flexible plates located at the bottom of VV lower port is proposed. This independent concept has two advantages: (1) thermal load due to the temperature deference between VV and the lower temperature components such as TF coil becomes lower and (2) the other components such as TF coil is categorized as a non-safety component because of its independence from VV. Stress analyses have been performed to assess the integrity of the VV support structure using a precisely modeled VV structure. As a result, (1) the maximum displacement of the VV corresponding to the relative displacement between VV and TF coil is found to be 15 mm, much less than the current design value of 100 mm, and (2) the stresses of the whole VV system including VV support are estimated to be less than the allowable ones defined by ASME Section III Subsection NF, respectively. Based on these assessments, the feasibility of the proposed independent VV support has been verified as a VV support. (author)

Static and dynamic analyses on the MFTF [Mirror Fusion Test Facility]-B Axicell Vacuum Vessel System: Final report

International Nuclear Information System (INIS)

Ng, D.S.

1986-09-01

The Mirror Fusion Test Facility (MFTF-B) at Lawrence Livermore National Laboratory (LLNL) is a large-scale, tandem-mirror-fusion experiment. MFTF-B comprises many highly interconnected systems, including a magnet array and a vacuum vessel. The vessel, which houses the magnet array, is supported by reinforced concrete piers and steel frames resting on an array of foundations and surrounded by a 7-ft-thick concrete shielding vault. The Pittsburgh-Des Moines (PDM) Corporation, which was awarded the contract to design and construct the vessel, carried out fixed-base static and dynamic analyses of a finite-element model of the axicell vessel and magnet systems, including the simulation of various loading conditions and three postulated earthquake excitations. Meanwhile, LLNL monitored PDM's analyses with modeling studies of its own, and independently evaluated the structural responses of the vessel in order to define design criteria for the interface members and other project equipment. The assumptions underlying the finite-element model and the behavior of the axicell vessel are described in detail in this report, with particular emphasis placed on comparing the LLNL and PDM studies and on analyzing the fixed-base behavior with the soil-structure interaction, which occurs between the vessel and the massive concrete vault wall during a postulated seismic event. The structural members that proved sensitive to the soil effect are also reevaluated

Kinematic analysis on rail development into vacuum vessel for ITER blanket maintenance

International Nuclear Information System (INIS)

Kakudate, Satoshi; Shibanuma, Kiyoshi

2006-01-01

The vehicle manipulator system for blanket maintenance is used as a main driving mechanism for rail development, and three driving mechanisms d1, d2 (or d2') and d3 are used as cycle sequence of the repeated operations for rail development. This repeated operation can develop the articulated rail into the vacuum vessel. The rail development scenario, kinematic analysis model for rail development without any driving mechanisms in the rail joints, equations defined the angular between two rail links, identification of rail link at repeated operation, numerical analysis results on rail deployment under the forced position control of l i+1 , new rail development scenario using two driving mechanisms d1 and d2''under one cycle sequence of the repeated operations, and rail development test are reported. (S.Y.)

Structural analysis of vacuum vessel and blanket support system for International Thermonuclear Experimental Reactor (ITER)

International Nuclear Information System (INIS)

Kitamura, Kazunori; Koizumi, Kouichi; Takatsu, Hideyuki; Tada, Eisuke; Shimane, Hideo.

1996-11-01

Structural analyses of vacuum vessel and blanket support system have been performed to examine their integrated structural behavior under the design loads and to assess their structural feasibility, with two kinds of three-dimensional (3-D) FEM models; a detailed model with 18deg sector region to investigate the detailed mechanical behaviors of the blanket and vessel components under the several symmetric loads, and a 180deg torus model with relatively coarser meshes to assess the structural responses under the asymmetric VDE load. The analytical results obtained by both models were also compared for the several symmetric loads to check the equivalent mechanical stiffness of the 180deg torus model. As the results, most of the vessel and blanket components have sufficient mechanical integrities with the stress level below the allowable limit of the materials, while the lower parts of inboard/outboard back plate need to be reinforced by increasing the thickness and/or mounting a toroidal ring support at the lower edge of the back plate. Two types of eigenvalue analyses were also conducted with the 180deg torus model to investigate natural frequencies of the vessel torus support system and to assess the mechanical integrity of the elastic stability under the asymmetric VDE load. Analytical results show that the mechanical stiffness of the vessel gravity support should be higher in the view point of a seismic response, and that those of the blanket support structures should also be increased for the buckling strength against the VDE vertical force. (author)

Lifetime measurement of ATF damping ring

International Nuclear Information System (INIS)

Okugi, T.; Hayano, H.; Kubo, K.; Naito, T.; Terunuma, N.; Urakawa, J.; Zimmermann, F.

1998-06-01

The purpose of the ATF damping ring is the development of technologies for producing a low emittance beam required in future linear colliders such as JLC. The lifetime of the damping ring is very short (typically a few minutes). It is limited by elastic beam-gas scattering along with a small dynamic aperture, and by single intra-beam scattering (Touschek effect). The Touschek lifetime strongly depends upon the charge density of the beam, especially, the size of the vertical emittance. In this paper, the authors report the results of beam lifetime measurements in the ATF damping ring and the estimation of the vertical emittance from these measurements

Turbomolecular pump vacuum system for the Princeton Large Torus

International Nuclear Information System (INIS)

Dylla, H.F.

1977-10-01

A turbomolecular pump vacuum system has been designed and installed on the Princeton Large Torus (PLT). Four vertical shaft, oil-bearing, 1500 l/s turbomolecular pumps have been interfaced to the 6400 liter PLT Vacuum vessel to provide a net pumping speed of 3000 l/s for H 2 . The particular requirements and problems of tokamak vacuum systems are enumerated. A vacuum control system is described which protects the vacuum vessel from contamination, and protects the turbomolecular pumps from damage under a variety of possible failure modes. The performance of the vacuum system is presented in terms of pumping speed measurements and residual gas behavior

Vacuum Systems Consensus Guideline for Department of Energy Accelerator Laboratories

Energy Technology Data Exchange (ETDEWEB)

Casey,R.; Haas, E.; Hseuh, H-C.; Kane, S.; Lessard, E.; Sharma, S.; Collins, J.; Toter, W. F.; Olis, D. R.; Pushka, D. R.; Ladd, P.; Jobe, R. K.

2008-09-09

Vacuum vessels, including evacuated chambers and insulated jacketed dewars, can pose a potential hazard to equipment and personnel from collapse, rupture due to back-fill pressurization, or implosion due to vacuum window failure. It is therefore important to design and operate vacuum systems in accordance with applicable and sound engineering principles. 10 CFR 851 defines requirements for pressure systems that also apply to vacuum vessels subject to back-fill pressurization. Such vacuum vessels are potentially subject to the requirements of the American Society of Mechanical Engineers (ASME) Pressure Vessel Code Section VIII (hereafter referred to as the 'Code'). However, the scope of the Code excludes vessels with internal or external operating pressure that do not exceed 15 pounds per square inch gauge (psig). Therefore, the requirements of the Code do not apply to vacuum systems provided that adequate pressure relief assures that the maximum internal pressure within the vacuum vessel is limited to less than 15 psig from all credible pressure sources, including failure scenarios. Vacuum vessels that cannot be protected from pressurization exceeding 15 psig are subject to the requirements of the Code. 10 CFR 851, Appendix A, Part 4, Pressure Safety, Section C addresses vacuum system requirements for such cases as follows: (c) When national consensus codes are not applicable (because of pressure range, vessel geometry, use of special materials, etc.), contractors must implement measures to provide equivalent protection and ensure a level of safety greater than or equal to the level of protection afforded by the ASME or applicable state or local code. Measures must include the following: (1) Design drawings, sketches, and calculations must be reviewed and approved by a qualified independent design professional (i.e., professional engineer). Documented organizational peer review is acceptable. (2) Qualified personnel must be used to perform examinations

Improvement of initial vacuum condition along 2008-2010 KSTAR campaign by vessel baking

Energy Technology Data Exchange (ETDEWEB)

Kim, Kwang Pyo, E-mail: kpkim@nfri.er.ke [National Fusion Research Institute, Gwahagno 113, Daejeon 305-333 (Korea, Republic of); Hong, S.H.; Jung, N.Y.; Kim, S.T.; Kim, H.T.; Lee, K.S.; Kim, K.M.; Bang, E.N.; Chang, Y.B.; Kim, H.K.; Chu, Y.; Kim, Y.O.; Park, S.H.; Woo, I.S.; Hong, J.S.; Kim, S.W.; Park, K.R.; Na, H.K.; Yang, H.L.; Kim, Y.S. [National Fusion Research Institute, Gwahagno 113, Daejeon 305-333 (Korea, Republic of)

2011-10-15

Korea Superconducting Tokamak Advanced Research (KSTAR) is upgraded for its KSTAR 3rd campaign for new target mission to produce the D-shaped plasma with a target plasma current of 500 kA and/or pulse length of 5 s. New Plasma Facing Components (PFCs) are installed which leads to the increase of the surface area of the vessel by a factor of about 5. The vacuum conditioning such as the vessel baking has been performed in order to remove various kinds of impurities including H{sub 2}O, carbon and oxygen for the plasma. The total outgassing rate in the KSTAR 1st campaign was measured as 1.5 x 10{sup -4} mbar l s{sup -1} which is increased by a factor of 3 (6.49 x 10{sup -4} mbar l s{sup -1}) in the KSTAR 3rd campaign. Nevertheless, the outgassing rates per unit area have been decreased from 9.31 x 10{sup -5} mbar l m{sup -2} s{sup -1} to 1.22 x 10{sup -5} mbar l m{sup -2} s{sup -1} due to the upgrade of baking system and series of baking operation.

Improvement of initial vacuum condition along 2008-2010 KSTAR campaign by vessel baking

International Nuclear Information System (INIS)

Kim, Kwang Pyo; Hong, S.H.; Jung, N.Y.; Kim, S.T.; Kim, H.T.; Lee, K.S.; Kim, K.M.; Bang, E.N.; Chang, Y.B.; Kim, H.K.; Chu, Y.; Kim, Y.O.; Park, S.H.; Woo, I.S.; Hong, J.S.; Kim, S.W.; Park, K.R.; Na, H.K.; Yang, H.L.; Kim, Y.S.

2011-01-01

Korea Superconducting Tokamak Advanced Research (KSTAR) is upgraded for its KSTAR 3rd campaign for new target mission to produce the D-shaped plasma with a target plasma current of 500 kA and/or pulse length of 5 s. New Plasma Facing Components (PFCs) are installed which leads to the increase of the surface area of the vessel by a factor of about 5. The vacuum conditioning such as the vessel baking has been performed in order to remove various kinds of impurities including H 2 O, carbon and oxygen for the plasma. The total outgassing rate in the KSTAR 1st campaign was measured as 1.5 x 10 -4 mbar l s -1 which is increased by a factor of 3 (6.49 x 10 -4 mbar l s -1 ) in the KSTAR 3rd campaign. Nevertheless, the outgassing rates per unit area have been decreased from 9.31 x 10 -5 mbar l m -2 s -1 to 1.22 x 10 -5 mbar l m -2 s -1 due to the upgrade of baking system and series of baking operation.

Experimental approach for adhesion strength of ATF cladding

Energy Technology Data Exchange (ETDEWEB)

Kim, Donghyun; Kim, Hyochan; Yang, Yongsik; In, Wangkee [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Kim, Haksung [Hanyang University, Seoul (Korea, Republic of)

2016-10-15

The quality of a coating depends on the quality of its adhesion bond strength between the coating and the underlying substrate. Therefore, it is essential to evaluate the adhesion properties of the coating. There are many available test methods for the evaluation of coatings adhesion bond strength. Considering these restrictions of the coated cladding, the scratch test is useful for evaluation of adhesion properties compared to other methods. The purpose of the present study is to analyze the possibility of adhesion bond strength evaluation of ATF coated cladding by scratch testing on coatings cross sections. Experimental approach for adhesion strength of ATF coated cladding was investigated in the present study. The scratch testing was chosen as a testing method. Uncoated zircaloy-4 tube was employed as a reference and plasma spray and arc ion coating were selected as a ATF coated claddings for comparison. As a result, adhesion strengths of specimens affect the measured normal and tangential forces. For the future, the test will be conducted for CrAl coated cladding by laser coating, which is the most promising ATF cladding. Computational analysis with finite element method will also be conducted to analyze a stress distribution in the cladding tube.

Advanced cutting, welding and inspection methods for vacuum vessel assembly and maintenance

Energy Technology Data Exchange (ETDEWEB)

Jones, L. E-mail: jonesl@ipp.mgg.de; Alfile, J.-P.; Aubert, Ph.; Punshon, C.; Daenner, W.; Kujanpaeae, V.; Maisonnier, D.; Serre, M.; Schreck, G.; Wykes, M

2000-11-01

ITER requires a 316 l stainless steel, double-skinned vacuum vessel (VV), each shell being 60 mm thick. EFDA (European Fusion Development Agreement) is investigating methods to be used for performing welding and NDT during VV assembly and also cutting and re-welding for remote sector replacement, including the development of an Intersector Welding Robot (IWR) [Jones et al. This conference]. To reduce the welding time, distortions and residual stresses of conventional welding, previous work concentrated on CO{sub 2} laser welding and cutting processes [Jones et al. Proc. Symp. Fusion Technol., Marseilles, 1998]. NdYAG laser now provides the focus for welding of the rearside root and for completing the weld for overhead positions with multipass filling. Electron beam (E-beam) welding with local vacuum offers a single-pass for most of the weld depth except for overhead positions. Plasma cutting has shown the capability to contain the backside dross and preliminary work with NdYAG laser cutting has shown good results. Automated ultrasonic inspection of assembly welds will be improved by the use of a phased array probe system that can focus the beam for accurate flaw location and sizing. This paper describes the recent results of process investigations in this R and D programme, involving five European sites and forming part of the overall VV/blanket research effort [W. Daenner et al. This conference].

CAVITY BEAM POSITION MONITOR SYSTEM FOR ATF2

CERN Document Server

Boogert, S T; Boorman, G; Molloy, S; Ross, M; Aryshev, A; Honda, Y; Terunuma, N; Urakawa, J; Kim, E S; Kim, Y I; Heo, A E; Lyapin, A; Swinson, C J; Frisch, J; McCormick, D M; Nelson, J; Smith, T; White, G R

2010-01-01

The Accelerator Test Facility 2 (ATF2) in KEK, Japan, is a prototype scaled demonstrator system for the final focus required for a future high energy lepton linear collider. The ATF2 beam-line is instrumented with a total of 38 C and S band resonant cavity beam position monitors (CBPM) with associated mixer electronics and digitizers. The current status of the BPM system is described, with a focus on operational techniques and performance.

Vibration measurement of accelerator tube table in ATF

International Nuclear Information System (INIS)

Nakayama, Y.; Sugahara, R.; Yamaoka, H.; Masuzawa, M.; Yamashita, S.

2004-01-01

Acceleration tube fixed to the table should not be a structure to amplify the vibration. Stability of ground is preferable for accelerator beam operation, and the beam control by extremely high resolution is especially demanded in GLC. Then, we have measured ground motion and table vibration in ATF at KEK. In this paper, some of analyzed results are shown, and we show the characteristics of vibration about the accelerator tube table in ATF. (author)

Design and fabrication methods of FW/blanket, divertor and vacuum vessel for ITER

International Nuclear Information System (INIS)

Ioki, K.; Barabash, V.; Cardella, A.; Elio, F.; Ibbott, C.; Janeschitz, G.; Johnson, G.; Kalinin, G.; Miki, N.; Onozuka, M.; Sannazzaro, G.; Tivey, R.; Utin, Y.; Yamada, M.

2000-01-01

Design has progressed on the vacuum vessel, FW/blanket and Divertor for the Reduced Technical Objective/Reduced Cost (RTO/RC) ITER. The basic functions and structures are the same as for the 1998 ITER design [K. Ioki et al., J. Nucl. Mater. 258-263 (1998) 74]. Design and fabrication methods of the components have been improved to achieve ∼50% reduction of the construction cost. Detailed blanket module designs with flat separable FW panels have been developed to reduce the fabrication cost and the future radioactive waste. Most of the R and D performed so far during the Engineering Design Activities (EDAs) are still applicable. Further cost reduction methods are also being investigated and additional R and D is being performed

Design and fabrication methods of FW/blanket, divertor and vacuum vessel for ITER

Energy Technology Data Exchange (ETDEWEB)

Ioki, K. E-mail: iokik@itereu.deiokik@ipp.mpg.de; Barabash, V.; Cardella, A.; Elio, F.; Ibbott, C.; Janeschitz, G.; Johnson, G.; Kalinin, G.; Miki, N.; Onozuka, M.; Sannazzaro, G.; Tivey, R.; Utin, Y.; Yamada, M

2000-12-01

Design has progressed on the vacuum vessel, FW/blanket and Divertor for the Reduced Technical Objective/Reduced Cost (RTO/RC) ITER. The basic functions and structures are the same as for the 1998 ITER design [K. Ioki et al., J. Nucl. Mater. 258-263 (1998) 74]. Design and fabrication methods of the components have been improved to achieve {approx}50% reduction of the construction cost. Detailed blanket module designs with flat separable FW panels have been developed to reduce the fabrication cost and the future radioactive waste. Most of the R and D performed so far during the Engineering Design Activities (EDAs) are still applicable. Further cost reduction methods are also being investigated and additional R and D is being performed.

Design progress of the ITER vacuum vessel sectors and port structures

International Nuclear Information System (INIS)

Utin, Yu.; Ioki, K.; Alekseev, A.; Bachmann, Ch.; Cho, S.; Chuyanov, V.; Jones, L.; Kuzmin, E.; Morimoto, M.; Nakahira, M.; Sannazzaro, G.

2007-01-01

Recent progress of the ITER vacuum vessel (VV) design is presented. As the ITER construction phase approaches, the VV design has been improved and developed in more detail with the focus on better performance, improved manufacture and reduced cost. Based on achievements of manufacturing studies, design improvement of the typical VV Sector (no. 1) has been nearly finalized. Design improvement of other sectors is in progress-in particular, of the VV Sectors no. 2 and no. 3 which interface with tangential ports for the neutral beam (NB) injection. For all sectors, the concept for the in-wall shielding has progressed and developed in more detail. The design progress of the VV sectors has been accompanied by the progress of the port structures. In particular, design of the NB ports was advanced with the focus on the beam-facing components to handle the heat input of the neutral beams. Structural analyses have been performed to validate all design improvements

Damping Wiggler Study at KEK-ATF

CERN Document Server

Naito, Takashi; Honda, Yosuke; Korostelev, Maxim S; Kubo, Kiyoshi; Kuriki, Masao; Kuroda, Shigeru; Muto, Toshiya; Nakamura, Norio; Ross, Marc; Sakai, Hiroshi; Terunuma, Nobuhiro; Urakawa, Junji; Zimmermann, Frank

2005-01-01

The effects by damping wiggler magnets have been studied at KEK-ATF. The damping ring of the KEK-ATF is a 1.3 GeV storage ring capable of producing ultra-low emittance electron beams. It is significant issue to realize fast damping in the damping ring. The tuning method with 4 sets of wiggler was investigated for the ultra-low emittance beam. The performance on the beam quality, which is related to the transverse (x and y) and the longitudinal (z and dp/p), has been measured by the SR monitor, the laser wire, the streak camera and the energy spread monitor at the extraction line. We report on the operation condition and the measurement results.

Thermal loads on the TJ-II Vacuum Vessel under Neutral Beam Injection

International Nuclear Information System (INIS)

Guasp, J.; Fuentes, C.; Liniers, M.

1996-01-01

In this study a numerical analysis of power loads on the complex 3D structure of the TJ-II Vacuum Vessel, moderated with reasonable accuracy, under NBI, is done. To do this it has been necessary to modify deeply the DENSB code for power loads in order to include the TJ-II VV wall parts as targets and as beam scrapers, allowing the possibility of self-shadowing. After a short description of the primitive version of the DENSB code (paragraph 2) and of the visualisation code MOVIE(paragraph 3), the DENSB upgrading are described (paragraphs 4,5) and finally the results are presented (paragraph 6). These code modifications and the improving on the visualization tools provide more realistic load evaluations, both with and without plasma, validating former results and showing clearly the VV zones that will need new protections. (Author)

Design of the ZTH vacuum liner

International Nuclear Information System (INIS)

Prince, P.P.; Dike, R.S.

1987-01-01

The current status of the ZTH vacuum liner design is covered by this report. ZTH will be the first experiment to be installed in the CPRF (Confinement Physics Research Facility) at the Los Alamos National Laboratory and is scheduled to be operational at the rated current of 4 MA in 1992. The vacuum vessel has a 2.4 m major radius and a 40 cm minor radius. Operating parameters which drive the vacuum vessel mechanical design include a 300 C bakeout temperature, an armour support system capable of withstanding 25 kV, a high toroidal resistance, 1250 kPa magnetic loading, a 10 minute cycle time, and high positional accuracy with respect to the conducting shell. The vacuum vessel design features which satisfy the operating parameters are defined. The liner is constructed of Inconel 625 and has a geometry which alternates sections of thin walled bellows with rigid ribs. These composite sections span between pairs of the 16 diagnostic stations to complete the torus. The thin bellows sections maximize the liner toroidal resistance and the ribs provide support and positional accuracy for the armour in relation to the conducting shell. Heat transfer from the vessel is controlled by a blanket wrap of ceramic fiber insulation and the heat flux is dissipated to a water cooling jacket in the conducting shell

ATF3 activates Stat3 phosphorylation through inhibition of p53 expression in skin cancer cells.

Science.gov (United States)

Hao, Zhen-Feng; Ao, Jun-Hong; Zhang, Jie; Su, You-Ming; Yang, Rong-Ya

2013-01-01

ATF3, a member of the ATF/CREB family of transcription factors, has been found to be selectively induced by calcineurin/NFAT inhibition and to enhance keratinocyte tumor formation, although the precise role of ATF3 in human skin cancer and possible mechanisms remain unknown. In this study, clinical analysis of 30 skin cancer patients and 30 normal donors revealed that ATF3 was accumulated in skin cancer tissues. Functional assays demonstrated that ATF3 significantly promoted skin cancer cell proliferation. Mechanically, ATF3 activated Stat3 phosphorylation in skin cancer cell through regulation of p53 expression. Moreover, the promotion effect of ATF3 on skin cancer cell proliferation was dependent on the p53-Stat3 signaling cascade. Together, the results indicate that ATF3 might promote skin cancer cell proliferation and enhance skin keratinocyte tumor development through inhibiting p53 expression and then activating Stat3 phosphorylation.

Structural Analysis for an Upper Port of the ITER Vacuum Vessel

International Nuclear Information System (INIS)

Yun-Seok Hong; Kwon, T. K.; Ahn, H. J.; Kim, Y.K.; Lee, C.D.

2006-01-01

The ITER vacuum vessel (VV) has numerous openings for the port structures including upper, equatorial, and lower ports used for equipment installation, utility feed through, vacuum pumping, and access into the vessel for maintenance. Every upper port, slanted upward slightly, has a trapezoidal/rectangular cross-section and consists of a port stub, a stub extension and a port extension with a connecting duct. To investigate the structural integrity and to increase the structural reliability of the VV and ports, the structural analyses of the upper port structure have been performed. The global structural analysis of the upper port with the in-port components has been carried out. The local analyses of a tangential key, an upper port flange, a connecting duct and a sealing unit have been performed. The design loads are dead weight, normal and abnormal pressure load, electromagnetic load, and seismic load in consideration of the dynamic amplification factors. The stress analyses were performed in a nonlinear elastic approach taking into account the contact surface between port extension flange and port plug flange. Two advanced designs from the ITER international team have been reviewed. To verify the strength of the reinforcing ribs for the connecting duct and of the fastening/sealing units, the local analyses utilizing the sub-modeling technique have been performed. The ASME code and the ITER design criteria were applied for the evaluation of the structural analysis results from the global and local analyses. The clearance between a port and a plug to accommodate the plug deformation has been assessed. The upper port flange based on the original design could withstand design loads, but there could be a gap on the flange surface under the design condition. The modified flange design, which is under the bolt friction only without tangential key was proposed. The deflection of the plug for an advanced design with a removable flange is higher than that for the original

An ATF4-ATG5 signaling in hypothalamic POMC neurons regulates obesity.

Science.gov (United States)

Xiao, Yuzhong; Deng, Yalan; Yuan, Feixiang; Xia, Tingting; Liu, Hao; Li, Zhigang; Chen, Shanghai; Liu, Zhixue; Ying, Hao; Liu, Yi; Zhai, Qiwei; Guo, Feifan

2017-06-03

ATF4 (activating transcription factor 4) is an important transcription factor that has many biological functions, while its role in hypothalamic POMC (pro-opiomelanocortin-α) neurons in the regulation of energy homeostasis has not been explored. We recently discovered that mice with an Atf4 deletion specific to POMC neurons (PAKO mice) are lean and have higher energy expenditure. Furthermore, these mice are resistant to high-fat diet (HFD)-induced obesity and obesity-related metabolic disorders. Mechanistically, we found the expression of ATG5 (autophagy-related 5) is upregulated in POMC neurons of PAKO mice, and ATF4 regulates ATG5 expression by binding directly to its promoter. Mice with Atf4 and Atg5 double knockout in POMC neurons have reduced energy expenditure and gain more fat mass compared with PAKO mice under a HFD. Finally, the effect of Atf4 knockout in POMC neurons is possibly mediated by enhanced ATG5-dependent macroautophagy/autophagy and α-melanocyte-stimulating hormone (α-MSH) production in the hypothalamus. Together, this work not only identifies a beneficial role for ATF4 in hypothalamic POMC neurons in the regulation of obesity, but also provides a new potential therapeutic target for obesity and obesity-related metabolic diseases.

Commissioning result of the KSTAR in-vessel cryo-pump

Energy Technology Data Exchange (ETDEWEB)

Chang, Y. B.; Lee, H. J.; Park, Y.M. [National Fusion Research Institute, Daejeon (Korea, Republic of); and others

2013-12-15

KSTAR in-vessel cryo-pump has been installed in the vacuum vessel top and bottom side with up-down symmetry for the better plasma density control in the D-shape H-mode. The cryogenic helium lines of the in-vessel cryo-pump are located at the vertical positions from the vacuum vessel torus center 2,000 mm. The inductive electrical potential has been optimized to reduce risk of electrical breakdown during plasma disruption. In-vessel cryo-pump consists of three parts of coaxial circular shape components; cryo-panel, thermal shield and particle shield. The cryo-panel is cooled down to below 4.5 K. The cryo-panel and thermal shields were made by Inconel 625 tube for higher mechanical strength. The thermal shields and their cooling tubes were annealed in air environment to improve the thermal radiation emissivity on the surface. Surface of cryo-panel was electro-polished to minimize the thermal radiation heat load. The in-vessel cryo-pump was pre-assembled on a test bed in 180 degree segment base. The leak test was carried out after the thermal shock between room temperature to LN2 one before installing them into vacuum vessel. Two segments were welded together in the vacuum vessel and final leak test was performed after the thermal shock. Commissioning of the in-vessel cryo-pump was carried out using a temporary liquid helium supply system.

A mobile robot with parallel kinematics to meet the requirements for assembling and machining the ITER vacuum vessel

Energy Technology Data Exchange (ETDEWEB)

Pessi, Pekka [Lappeenranta University of Technology, Lappeenranta (Finland)], E-mail: pessi@lut.fi; Wu, Huapeng; Handroos, Heikki [Lappeenranta University of Technology, Lappeenranta (Finland); Jones, Lawrence [EFDA Close Support Unit, Boltzmannstrasse 2, Garching D-85748 (Germany)

2007-10-15

The present paper introduces a mobile parallel robot developed for International Thermonuclear Experimental Reactor (ITER). The task of the robot is to carry out welding and machining processes inside the ITER vacuum vessel. The kinematic design of the robot has been optimized for the ITER access. The kinematic analysis is given in the paper. A virtual prototype of the parallel robot is built. A dynamic behavior of the whole robot is studied by the multi-body system simulation (MBS)

A mobile robot with parallel kinematics to meet the requirements for assembling and machining the ITER vacuum vessel

International Nuclear Information System (INIS)

Pessi, Pekka; Wu, Huapeng; Handroos, Heikki; Jones, Lawrence

2007-01-01

The present paper introduces a mobile parallel robot developed for International Thermonuclear Experimental Reactor (ITER). The task of the robot is to carry out welding and machining processes inside the ITER vacuum vessel. The kinematic design of the robot has been optimized for the ITER access. The kinematic analysis is given in the paper. A virtual prototype of the parallel robot is built. A dynamic behavior of the whole robot is studied by the multi-body system simulation (MBS)

Inverse Cerenkov laser acceleration experiment at ATF

International Nuclear Information System (INIS)

Wang, X.J.; Pogorelsky, I.; Fernow, R.; Kusche, K.P.; Liu, Y.; Kimura, W.D.; Kim, G.H.; Romea, R.D.; Steinhauer, L.C.

1994-01-01

Inverse Cerenkov laser acceleration was demonstrated using an axicon optical system at the Brookhaven Accelerator Test Facility (ATF). The ATF S-band linac and a high power 10.6 μm CO 2 laser were used for the experiment. Experimental arrangement and the laser and the electron beams synchronization are discussed. The electrons were accelerated more than 0.7 MeV for a 34 MW CO 2 laser power. More than 3.7 MeV acceleration was measured with 0.7 GW CO 2 laser power, which is more than 20 times of the previous ICA experiment. The experimental results are compared with computer program TRANSPORT simulations

p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization

Science.gov (United States)

Fox, Daniel K.; Ebert, Scott M.; Bongers, Kale S.; Dyle, Michael C.; Bullard, Steven A.; Dierdorff, Jason M.; Kunkel, Steven D.

2014-01-01

Immobilization causes skeletal muscle atrophy via complex signaling pathways that are not well understood. To better understand these pathways, we investigated the roles of p53 and ATF4, two transcription factors that mediate adaptations to a variety of cellular stresses. Using mouse models, we demonstrate that 3 days of muscle immobilization induces muscle atrophy and increases expression of p53 and ATF4. Furthermore, muscle fibers lacking p53 or ATF4 are partially resistant to immobilization-induced muscle atrophy, and forced expression of p53 or ATF4 induces muscle fiber atrophy in the absence of immobilization. Importantly, however, p53 and ATF4 do not require each other to promote atrophy, and coexpression of p53 and ATF4 induces more atrophy than either transcription factor alone. Moreover, muscle fibers lacking both p53 and ATF4 are more resistant to immobilization-induced atrophy than fibers lacking only p53 or ATF4. Interestingly, the independent and additive nature of the p53 and ATF4 pathways allows for combinatorial control of at least one downstream effector, p21. Using genome-wide mRNA expression arrays, we identified p21 mRNA as a skeletal muscle transcript that is highly induced in immobilized muscle via the combined actions of p53 and ATF4. Additionally, in mouse muscle, p21 induces atrophy in a manner that does not require immobilization, p53 or ATF4, and p21 is required for atrophy induced by immobilization, p53, and ATF4. Collectively, these results identify p53 and ATF4 as essential and complementary mediators of immobilization-induced muscle atrophy and discover p21 as a critical downstream effector of the p53 and ATF4 pathways. PMID:24895282

Weld defects analysis of 60 mm thick SS316L mock-ups of TIG and EB welds by ultrasonic inspection for fusion reactor vacuum vessel applications

International Nuclear Information System (INIS)

Buddu, Ramesh Kumar; Shaikh, Shamsuddin; Raole, P.M.; Sarkar, B.

2015-01-01

The present paper reports the weld quality inspections carried with 60 mm thick AISI welds of SS316L. The high thickness steel plates requirement is due to the specific applications in case of advanced fusion reactor structural components like vacuum vessel and others. Different kind welds are proposed for the thick plate joints like Tungsten Inert Gas (TIG) welding, Electron beam welding as per stringent conditions (like very low distortions and residual stresses) for the vacuum vessel fabrication. Mock-ups of laboratory scale welds are fabricated by TIG (multi-pass) and EB (double pass) process techniques and different weld quality inspections are carried by different NDT tests. The welds are examined with Liquid penetrant examination to check sub surface cracks/discontinuities towards the defects observation

Fluctuations and confinement in ATF

International Nuclear Information System (INIS)

Isler, R.C.; Harris, J.H.; Murakami, M.

1993-01-01

In the period immediately prior to the suspension of ATF operation in November, 1991, a great deal of emphasis was palced on investigations of the fundamental mechanisms controlling confinement in this device. At that time, measurements of the density fluctuations throughout the plasma volume indicated the existence of theoretically predicted dissipative trapped electron and resistive interchange instabilities. These identifications were supported by results of dynamic configuration scans of the magnetic fields during which the extent of the magnetic well, shear, and fraction of confined trapped particles were changed continuously. Interpretation of the data from these experiments has been an ongoing exercise. Most recently, analysis of discharges employing strong gas puffing to change density gradients and fluctuation levels have strengthened the view that dissipative trapped electron modes may be present but do not play a significant direct role in energy transport. The present paper summarizes the current understanding concerning the identification of instabilities and their relationship to confinement in ATF

Evaporation under vacuum condition

International Nuclear Information System (INIS)

Mizuta, Satoshi; Shibata, Yuki; Yuki, Kazuhisa; Hashizume, Hidetoshi; Toda, Saburo; Takase, Kazuyuki; Akimoto, Hajime

2000-01-01

In nuclear fusion reactor design, an event of water coolant ingress into its vacuum vessel is now being considered as one of the most probable accidents. In this report, the evaporation under vacuum condition is evaluated by using the evaporation model we have developed. The results show that shock-wave by the evaporation occurs whose behavior strongly depends on the initial conditions of vacuum. And in the case of lower initial pressure and temperature, the surface temp finally becomes higher than other conditions. (author)

Advanced Toroidal Facility

International Nuclear Information System (INIS)

Johnson, R.L.

1985-01-01

The Advanced Toroidal Facility (ATF) is a new magnetic confinement plasma device under construction at the Oak Ridge National Laboratory (ORNL) that will lead to improvements in toroidal magnetic fusion reactors. The ATF is a type of stellerator, known as a ''torsatron'' which theoretically has the capability to operate at greater than or equal to8% beta in steady state. The ATF plasma has a major radius of 2.1 m, an average minor radius of 0.3 m, and a field of 2 T for a 2 s duration or 1 T steady state. The ATF device consists of a helical field (HF) coil set, a set of poloidal field (PF) coils, an exterior shell structure to support the coils, and a thin, helically contoured vacuum vessel inside the coils. The ATF replaces the Impurities Studies Experiment (ISX-B) tokamak at ORNL and will use the ISX-B auxiliary systems including 4 MW of electron cyclotron heating. The ATF is scheduled to start operation in late 1986. An overview of the ATF device is presented, including details of the construction process envisioned. 9 refs., 7 figs., 3 tabs

Bolometric measurements in ATF

International Nuclear Information System (INIS)

Hiroe, S.; Wilgen, J.B.; Batchelor, D.B.; Bigelow, T.S.; Wing, W.R.; Bell, G.L.; Gandy, R.F.; Goldfinger, R.C.; Kindsfather, R.R.

1989-01-01

Bolometer measurements are made under various plasma conditions in ATF. Each bolometer module includes four pairs of detectors; each pair consists of a sensor and a reference detector. Two or three detector pairs in each module were installed with various types of aperture masks to serve as radiation detectors. The rest were completely shielded from plasma emissions and used as blind detectors to measure background levels. When electron cyclotron heating (ECH) power was applied to ATF, the radiation signal was more than 10 times higher than that expected for 100 kW of radiated power. Surprisingly, similar signal levels were observed on the blind detectors. It is hypothesized that the bolometers are sensitive to ECH power at 53 GHz. (This problem may be general in near-term fusion experiments, in which microwave power will be an important tool for plasma heating.) In this paper, experiments aimed at proving this hypothesis are reported; bolometric signals before and after chromium gettering are discussed; and measurements of the microwave power deposition profile around the torus, made by using the observed microwave interference with the blind detectors, are presented. 4 refs., 4 figs

Large eddy simulation of Loss of Vacuum Accident in STARDUST facility

International Nuclear Information System (INIS)

Benedetti, Miriam; Gaudio, Pasquale; Lupelli, Ivan; Malizia, Andrea; Porfiri, Maria Teresa; Richetta, Maria

2013-01-01

Highlights: ► Fusion safety, plasma material interaction. ► Numerical and experimental data comparison to analyze the consequences of Loss of Vacuum Accident that can provoke dust mobilization inside the Vacuum Vessel of the Nuclear Fusion Reactor ITER-like. -- Abstract: The development of computational fluid dynamic (CFD) models of air ingress into the vacuum vessel (VV) represents an important issue concerning the safety analysis of nuclear fusion devices, in particular in the field of dust mobilization. The present work deals with the large eddy simulations (LES) of fluid dynamic fields during a vessel filling at near vacuum conditions to support the safety study of Loss of Vacuum Accidents (LOVA) events triggered by air income. The model's results are compared to the experimental data provided by STARDUST facility at different pressurization rates (100 Pa/s, 300 Pa/s and 500 Pa/s). Simulation's results compare favorably with experimental data, demonstrating the possibility of implementing LES in large vacuum systems as tokamaks

Design and analysis of the vacuum vessel for RTO/RC-ITER

International Nuclear Information System (INIS)

Onozuka, M.; Ioki, K.; Johnson, G.; Kodama, T.; Sannazzaro, G.; Utin, Y.

2000-01-01

Recent progress in design and analysis of the vacuum vessel (VV) for the reduced technical objectives/reduced cost International Thermonuclear Experimental Reactor (RTO/RC-ITER) is presented. The basic VV design is similar to the previous ITER VV. However, because the back plate for the blanket modules could be eliminated, its previous functions could be transferred to the VV. For this option, the blanket modules are supported directly by the VV and the blanket coolant channels are structurally part of the VV double wall structure. In addition, a 'tight fitting' configuration is required to correctly position the modules' first wall. Although such modifications of the VV complicate its structure and increase its fabrication cost, the design of the VV is considered to be still feasible. The structural analyses of the VV have been conducted using several FE models of the VV, including global and local models. Although further assessment is required, based on the analyses performed to date, the structural aspects of the VV for the case without the back plate appear feasible

Design and analysis of the vacuum vessel for RTO/RC-ITER

Energy Technology Data Exchange (ETDEWEB)

Onozuka, M. E-mail: onozukm@itereu.de; Ioki, K.; Johnson, G.; Kodama, T.; Sannazzaro, G.; Utin, Y

2000-11-01

Recent progress in design and analysis of the vacuum vessel (VV) for the reduced technical objectives/reduced cost International Thermonuclear Experimental Reactor (RTO/RC-ITER) is presented. The basic VV design is similar to the previous ITER VV. However, because the back plate for the blanket modules could be eliminated, its previous functions could be transferred to the VV. For this option, the blanket modules are supported directly by the VV and the blanket coolant channels are structurally part of the VV double wall structure. In addition, a 'tight fitting' configuration is required to correctly position the modules' first wall. Although such modifications of the VV complicate its structure and increase its fabrication cost, the design of the VV is considered to be still feasible. The structural analyses of the VV have been conducted using several FE models of the VV, including global and local models. Although further assessment is required, based on the analyses performed to date, the structural aspects of the VV for the case without the back plate appear feasible.

The ATF [Advanced Toroidal Facility] Data Management System: [Final report

International Nuclear Information System (INIS)

Kannan, K.L.; Baylor, L.R.

1987-01-01

The Advanced Toroidal Facility (ATF) Data Management System (DMG) is a VAX-based software system that provides unified data access for ATF data acquisition and analysis. The system was designed with user accessibility, software maintainability, and extensibility as primary goals. This paper describes the layered architecture of the system design, the system implementation, use, and the data file structure. 3 refs., 1 fig

Mechanical properties and microstructural investigations of TIG welded 40 mm and 60 mm thick SS 316L samples for fusion reactor vacuum vessel applications

Energy Technology Data Exchange (ETDEWEB)

Buddu, Ramesh Kumar, E-mail: brkumar75@gmail.com; Chauhan, N.; Raole, P.M.

2014-12-15

Highlights: • Austenitic stainless steels (316L) of 40 mm and 60 mm thickness plates were joined by Tungsten Inert Gas welding (TIG) process which are probable materials for advanced fusion reactor vacuum vessel requirements. • Mechanical properties and detailed microstructure studies have been carried out for welded samples. • Fractography analysis of impact test specimens indicated ductile fracture mode in BM, HAZ and WZ samples. • Presence of delta ferrite phase was observed in the welded zone and ferrite number data was measured for the base and weld metal and was found high in welds. - Abstract: The development of advanced fusion reactors like DEMO will have various challenges in materials and fabrication. The vacuum vessel is important part of the fusion reactor. The double walled design for vacuum vessel with thicker stainless steel material (40–60 mm) has been proposed in the advanced fusion reactors like ITER. Different welding techniques will have to be used for such vacuum vessel development. The required mechanical, structural and other properties of stainless steels have to be maintained in these joining processes of components of various shapes and sizes in the form of plates, ribs, shells, etc. The present paper reports characterization of welding joints of SS316L plates with higher thicknesses like 40 mm and 60 mm, prepared using multi-pass Tungsten Inert Gas (TIG) welding process. The weld quality has been evaluated with non-destructive tests by X-ray radiography and ultrasonic methods. The mechanical properties like tensile, bend tests, Vickers hardness and impact fracture tests have been carried out for the weld samples. Tensile property test results indicate sound weld joints with efficiencies over 100%. Hardening was observed in the weld zone in non-uniform manner. Macro and microstructure studies have been carried out for Base Metal (BM), Heat Affected Zone (HAZ) and Weld Zone (WZ). Scanning Electron Microscopy (SEM) analysis carried

Mechanical properties and microstructural investigations of TIG welded 40 mm and 60 mm thick SS 316L samples for fusion reactor vacuum vessel applications

International Nuclear Information System (INIS)

Buddu, Ramesh Kumar; Chauhan, N.; Raole, P.M.

2014-01-01

Highlights: • Austenitic stainless steels (316L) of 40 mm and 60 mm thickness plates were joined by Tungsten Inert Gas welding (TIG) process which are probable materials for advanced fusion reactor vacuum vessel requirements. • Mechanical properties and detailed microstructure studies have been carried out for welded samples. • Fractography analysis of impact test specimens indicated ductile fracture mode in BM, HAZ and WZ samples. • Presence of delta ferrite phase was observed in the welded zone and ferrite number data was measured for the base and weld metal and was found high in welds. - Abstract: The development of advanced fusion reactors like DEMO will have various challenges in materials and fabrication. The vacuum vessel is important part of the fusion reactor. The double walled design for vacuum vessel with thicker stainless steel material (40–60 mm) has been proposed in the advanced fusion reactors like ITER. Different welding techniques will have to be used for such vacuum vessel development. The required mechanical, structural and other properties of stainless steels have to be maintained in these joining processes of components of various shapes and sizes in the form of plates, ribs, shells, etc. The present paper reports characterization of welding joints of SS316L plates with higher thicknesses like 40 mm and 60 mm, prepared using multi-pass Tungsten Inert Gas (TIG) welding process. The weld quality has been evaluated with non-destructive tests by X-ray radiography and ultrasonic methods. The mechanical properties like tensile, bend tests, Vickers hardness and impact fracture tests have been carried out for the weld samples. Tensile property test results indicate sound weld joints with efficiencies over 100%. Hardening was observed in the weld zone in non-uniform manner. Macro and microstructure studies have been carried out for Base Metal (BM), Heat Affected Zone (HAZ) and Weld Zone (WZ). Scanning Electron Microscopy (SEM) analysis carried

Activation of the JET vacuum vessel: a comparison of calculated with measured gamma-radiation fluxes and dose rates

International Nuclear Information System (INIS)

Jarvis, O.N.; Sadler, G.; Avery, A.; Verschuur, K.A.

1988-01-01

The gamma-radiation dose-rates inside the JET vacuum vessel due to induced radioactivity were measured at intervals throughout the 1986 period of operation, and the decay gamma energy spectrum was measured during the subsequent lengthy shutdown. The dose-rates were found to be in good agreement with values calculated using the neutron yield records compiled from the time-resolved neutron yield monitor responses for individual discharges. This result provides strong support for the reliability of the neutron yield monitor calibration. (author)

Impacts of lost fast ions on the TJ-II Vacuum Vessel during NBI

International Nuclear Information System (INIS)

Guasp, J.

1995-01-01

The possible deposition patterns, on the Vacuum Vessel, of lost fast ions during the balanced tangential NBI in TJ-II helical axis Stellarator are analysed theoretically, establishing the relation between those impact points, the plasma exit and birth positions and the magnetic configuration characteristics. It is shown that direct losses are the most important, mainly those produced by the beam injected with the same direction that the magnetic field, increasing with beam energy and plasma density but with impacts remaining fixed on well defined zones, a periodically distributed along the Hard Core cover plates, producing high loads at high densities. The remaining losses, except for the shine through ones that predominate at low density, are periodically distributed, with smooth maxima and produce very low loads. No overlapping between the different kind of losses or beams is observed. (Author) 6 refs

Impacts of lost fast ions on the TJ-II Vacuum vessel during NBI

International Nuclear Information System (INIS)

Guasp, J.

1995-09-01

The possible deposition patterns, on the Vacuum Vessel, of lost fast ions during the balanced tangential NBI in TJ-II helical axis Stellarator are analysed theoretically, establishing the relation between those impact points, the plasma exit and birth positions and positions and the magnetic configuration characteristics. It is shown that direct losses are the most important, mainly those produced by the beam injected with the same direction that the magnetic field, increasing with beam energy and plasma density but with impacts remaining fixed on well defined zones, a periodically distributed along the Hard Core cover plates, producing high loads at high densities. The remaining losses, except for the shine through ones that predominate at low density, are periodically distributed, with smooth maxima and produce very low loads. No overlapping between the different kind of losses or beams is observed

Electron cyclotron heating calculations for ATF

International Nuclear Information System (INIS)

Goldfinger, R.C.; Batchelor, D.B.

1986-03-01

The RAYS geometrical optics code has been used to calculate electron cyclotron wave propagation and heating in the Advanced Toroidal Facility (ATF) device under construction at Oak Ridge National Laboratory (ORNL). The intent of this work is to predict the outcome of various heating scenarios and to give guidance in designing an optimum heating system. Particular attention is paid to the effects of wave polarization and antenna location. We investigate first and second harmonic cyclotron heating with the parameters predicted for steady-state ATF operation. We also simulate the effect of wall reflections by calculating a uniform, isotropic flux of power radiating from the wall. These results, combined with the first-pass calculations, give a qualitative picture of the heat deposition profiles. From these results we identify the compromises that represent the optimum heating strategies for the ATF model considered here. Our basic conclusions are that second harmonic heating with the extraordinary mode (X-mode) gives the best result, with fundamental ordinary mode (O-mode) heating being slightly less efficient. Assuming the antenna location is restricted to the low magnetic field side, the antenna should be placed at phi = 0 0 (the toroidal angle where the helical coils are at the sides) for fundamental heating and at phi = 15 0 (where the helical coils are at the top and bottom) for second harmonic heating. These recommendations come directly from the ray tracing results as well as from a theoretical identification of the relevant factors affecting the heating

Gene expression analysis in human breast cancer associated blood vessels.

Directory of Open Access Journals (Sweden)

Dylan T Jones

Full Text Available Angiogenesis is essential for solid tumour growth, whilst the molecular profiles of tumour blood vessels have been reported to be different between cancer types. Although presently available anti-angiogenic strategies are providing some promise for the treatment of some cancers it is perhaps not surprisingly that, none of the anti-angiogenic agents available work on all tumours. Thus, the discovery of novel anti-angiogenic targets, relevant to individual cancer types, is required. Using Affymetrix microarray analysis of laser-captured, CD31-positive blood vessels we have identified 63 genes that are upregulated significantly (5-72 fold in angiogenic blood vessels associated with human invasive ductal carcinoma (IDC of the breast as compared with blood vessels in normal human breast. We tested the angiogenic capacity of a subset of these genes. Genes were selected based on either their known cellular functions, their enriched expression in endothelial cells and/or their sensitivity to anti-VEGF treatment; all features implicating their involvement in angiogenesis. For example, RRM2, a ribonucleotide reductase involved in DNA synthesis, was upregulated 32-fold in IDC-associated blood vessels; ATF1, a nuclear activating transcription factor involved in cellular growth and survival was upregulated 23-fold in IDC-associated blood vessels and HEX-B, a hexosaminidase involved in the breakdown of GM2 gangliosides, was upregulated 8-fold in IDC-associated blood vessels. Furthermore, in silico analysis confirmed that AFT1 and HEX-B also were enriched in endothelial cells when compared with non-endothelial cells. None of these genes have been reported previously to be involved in neovascularisation. However, our data establish that siRNA depletion of Rrm2, Atf1 or Hex-B had significant anti-angiogenic effects in VEGF-stimulated ex vivo mouse aortic ring assays. Overall, our results provide proof-of-principle that our approach can identify a cohort of

Plasma modeling of MFTF-B and the sensitivity to vacuum conditions

International Nuclear Information System (INIS)

Porter, G.D.; Rensink, M.

1984-01-01

The Mirror Fusion Test Facility (MFTF-B) is a large tandem mirror device currently under construction at Lawrence Livermore National Laboratory. The completed facility will consist of a large variety of components. Specifically, the vacuum vessel that houses the magnetic coils is basically a cylindrical vessel 60 m long and 11 m in diameter. The magnetics system consists of some 28 superconducting coils, each of which is located within the main vacuum vessel. Twenty of these coils are relatively simple solenoidal coils, but the remaining eight are of a more complicated design to provide an octupole component to certain regions of the magnetic field. The vacuum system is composed of a rough vacuum chain, used to evacuate the vessel from atmospheric pressure, and a high vacuum system, used to maintain good vacuum conditions during a plasma shot. High vacuum pumping is accomplished primarily by cryogenic panels cooled to 4.5 0 K. The MFTF-B coil set is shown together with typical axial profiles of magnetic field (a), electrostatic potential (b), and plasma density (c). The plasma is divided into nine regions axially, as labelled on the coil set in Figure 1. The central cell, which is completely azimuthally symmetric, contains a large volume plasma that is confined by a combination of the magnetic fields and the electrostatic potentials in the yin-yang cell

The JET high temperature in-vessel inspection system

International Nuclear Information System (INIS)

Businaro, T.; Cusack, R.; Calbiati, L.; Raimondi, T.

1989-01-01

The JET In-vessel Inspection System (IVIS) has been enhanced for operation under the following nominal conditions: vacuum vessel at 350 degC; vacuum vessel evacuated (∼10 -9 mbar); radiation dose during D-T phase 10 rads. The target resolution of the pictures is 2 mm at 5 m distance and tests on radiation resistance of the IVIS system are being carried out. Since June 1988, the new system is installed in the JET machine and the first inspections of the intire vessel at 250 degC have been satisfactory done. (author). 3 refs.; 6 figs.; 1 tab

Loss of ATF2 function leads to cranial motoneuron degeneration during embryonic mouse development.

Directory of Open Access Journals (Sweden)

Julien Ackermann

2011-04-01

Full Text Available The AP-1 family transcription factor ATF2 is essential for development and tissue maintenance in mammals. In particular, ATF2 is highly expressed and activated in the brain and previous studies using mouse knockouts have confirmed its requirement in the cerebellum as well as in vestibular sense organs. Here we present the analysis of the requirement for ATF2 in CNS development in mouse embryos, specifically in the brainstem. We discovered that neuron-specific inactivation of ATF2 leads to significant loss of motoneurons of the hypoglossal, abducens and facial nuclei. While the generation of ATF2 mutant motoneurons appears normal during early development, they undergo caspase-dependent and independent cell death during later embryonic and foetal stages. The loss of these motoneurons correlates with increased levels of stress activated MAP kinases, JNK and p38, as well as aberrant accumulation of phosphorylated neurofilament proteins, NF-H and NF-M, known substrates for these kinases. This, together with other neuropathological phenotypes, including aberrant vacuolisation and lipid accumulation, indicates that deficiency in ATF2 leads to neurodegeneration of subsets of somatic and visceral motoneurons of the brainstem. It also confirms that ATF2 has a critical role in limiting the activities of stress kinases JNK and p38 which are potent inducers of cell death in the CNS.

Design of the ZTH vacuum liner

International Nuclear Information System (INIS)

Prince, P.P.

1987-01-01

The current status of the ZTH vacuum liner design is covered by this report. ZTH will be the first experiment to be installed in the CPRF (Confinement Physics Research Facility) at the Los Alamos National Laboratory and is scheduled to be operational at 2 MA in 1990 and at the rated current of 4 MA in 1992. The vacuum vessel has a 2.4m major radius and a 40 cm minor radius. The vacuum vessel design features which satisfy the operating parameters are defined. The liner is constructed of Inconel 625 and has a geometry which alternates sections of thin walled bellows with rigid ribs. These composite sections span between pairs of the 16 diagnostic stations to complete the torus. The thin bellows sections maximize the liner toroidal resistance and the ribs provide support and positional accuracy for the armour in relation to the conducting shell. Heat transfer from the vessel is controlled by a blanket wrap of ceramic fiber insulation and the heat flux is dissipated to a water cooling jacket in the conducting shell. 7 figs., 1 tab

Assessment of W7-X plasma vessel pressurisation in case of LOCA taking into account in-vessel components

Energy Technology Data Exchange (ETDEWEB)

Urbonavičius, E., E-mail: Egidijus.Urbonavicius@lei.lt; Povilaitis, M., E-mail: Mantas.Povilaitis@lei.lt; Kontautas, A., E-mail: Aurimas.Kontautas@lei.lt

2015-11-15

Highlights: • Analysis of the vacuum vessel response to the LOCA in W7-X was performed using lumped-parameter codes COCOSYS and ASTEC. • Benchmarking of the results received with two codes provides more confidence in results and helps in identification of possible important differences in the modelling. • The performed analysis answered the questions set in the installed plasma vessel venting system during overpressure of PV in case of 40 mm diameter LOCA in “baking” mode. • Differences in time until opening the burst disk observed in ASTEC and COCOSYS results are caused by differences in heat transfer modelling. - Abstract: This paper presents the analysis of W7-X vacuum vessel response taking into account in-vessel components. A detailed analysis of the vacuum vessel response to the loss of coolant accident was performed using lumped-parameter codes COCOSYS and ASTEC. The performed analysis showed that the installed plasma vessel venting system prevents overpressure of PV in case of 40 mm diameter LOCA in “baking” mode. The performed analysis revealed differences in heat transfer modelling implemented in ASTEC and COCOSYS computer codes, which require further investigation to justify the correct approach for application to fusion facilities.

Assessment of W7-X plasma vessel pressurisation in case of LOCA taking into account in-vessel components

International Nuclear Information System (INIS)

Urbonavičius, E.; Povilaitis, M.; Kontautas, A.

2015-01-01

Highlights: • Analysis of the vacuum vessel response to the LOCA in W7-X was performed using lumped-parameter codes COCOSYS and ASTEC. • Benchmarking of the results received with two codes provides more confidence in results and helps in identification of possible important differences in the modelling. • The performed analysis answered the questions set in the installed plasma vessel venting system during overpressure of PV in case of 40 mm diameter LOCA in “baking” mode. • Differences in time until opening the burst disk observed in ASTEC and COCOSYS results are caused by differences in heat transfer modelling. - Abstract: This paper presents the analysis of W7-X vacuum vessel response taking into account in-vessel components. A detailed analysis of the vacuum vessel response to the loss of coolant accident was performed using lumped-parameter codes COCOSYS and ASTEC. The performed analysis showed that the installed plasma vessel venting system prevents overpressure of PV in case of 40 mm diameter LOCA in “baking” mode. The performed analysis revealed differences in heat transfer modelling implemented in ASTEC and COCOSYS computer codes, which require further investigation to justify the correct approach for application to fusion facilities.

Manufacturing preparations for the European Vacuum Vessel Sector for ITER

International Nuclear Information System (INIS)

Jones, Lawrence; Arbogast, Jean François; Bayon, Angel; Bianchi, Aldo; Caixas, Joan; Facca, Aldo; Fachin, Gianbattista; Fernández, José; Giraud, Benoit; Losasso, Marcello; Löwer, Thorsten; Micó, Gonzalo; Pacheco, Jose Miguel; Paoletti, Roberto; Sanguinetti, Gian Paolo; Stamos, Vassilis; Tacconelli, Massimiliano; Trentea, Alexandru; Utin, Yuri

2012-01-01

The contract for the seven European Sectors of the ITER Vacuum Vessel, which has very tight tolerances and high density of welding, was placed at the end of 2010 with AMW, a consortium of three companies. The start-up of the engineering, including R and D, design and analysis activities of this large and complex contract, one of the largest placed by F4E, the European Domestic Agency for ITER, is described. The statutory and regulatory requirements of ITER Organization and the French Nuclear Safety regulations have made the design development subject to rigorous controls. AMW was able to make use of the previous extensive R and D and prototype work carried out during the past 9 years, especially in relation to advanced welding and inspection techniques. The paper describes the manufacturing methodology with the focus on controlling distortion with predictions by analysis, avoiding use of welded-on jigs, and making use of low heat input narrow-gap welding with electron beam welding as far as possible and narrow-gap TIG when not. Further R and D and more than ten significant mock-ups are described. All these preparations will help to assure the successful manufacture of this critical path item of ITER.

Results from ITER Vacuum Vessel Sector Manufacturing Development in Europe

International Nuclear Information System (INIS)

Jones, L.

2006-01-01

Significant results have been achieved since the previous SOFT conference, when the manufacturing development work required to prepare for the ITER Vacuum Vessel Sector was described. The contract for the manufacture of a full-size, 20 Ton poloidal part of the inboard section, fabricated according to the ITER reference manufacturing route, including bracing fixtures, welding applications, restraint effects, and fit-up aspects is approaching completion. Since the main aim of the work is to establish the practicability of achieving the tight dimensional tolerances, an accompanying SYSWELD analysis programme has been validation by instrumented welding coupons, and then used for predicting the distortion of the actual construction. A local machining tool has been developed to allow the requirement for machining of the cylindrical features at a late stage of manufacture. Experimental and analytical work has also been carried out to establish the possibility of 3-D cold-forming large sections of walls of the VV. A manufacturing programme to validate an alternative method of fabricating parts of the double-walled VV, utilising e-beam welding only and avoiding the quality issues of the one-sided access and inspection of the closing welds is presented. This paper describes the results of the manufacturing development programme and the future activities. (author)

Impacts of the CX neutrals on the Vacuum Vessel of TJ-II during NBI

International Nuclear Information System (INIS)

Guasp, J.

1995-09-01

A numerical analysis of the impact patterns on the Vacuum Vessel produced by CX neutrals during the tangential balanced NBI in TJ-II Helical Axis Stellerator has been done. The results show periodical distribution with smooth maxima and mild loads, concentrated prefentlyon the HC plates. A certain preference of these neutral to emerge downwards from the plasma appears, as consequence of a similar trend for the trapped particles. The differences between the impacts produced by the beam paralel to the magnetic field and the opposite one are small, once more as a consequence of the loss of memory of trapped particles to initial direction. The dependence of loads with plasma density and beam energy follows the trend of CX losses, decreasing strongly with increasing density and decreasing, more smoothly, with energy

Manufacture of EAST VS In-Vessel Coil

International Nuclear Information System (INIS)

Long, Feng; Wu, Yu; Du, Shijun; Jin, Huan; Yu, Min; Han, Qiyang; Wan, Jiansheng; Liu, Bin; Qiao, Jingchun; Liu, Xiaochuan; Li, Chang; Cai, Denggang; Tong, Yunhua

2013-01-01

Highlights: • ITER like Stainless Steel Mineral Insulation Conductor (SSMIC) used for EAST Tokamak VS In-Vessel Coil manufacture first time. • Research on SSMIC fabrication was introduced in detail. • Two sets totally four single-turn VS coils were manufactured and installed in place symmetrically above and below the mid-plane in the vacuum vessel of EAST. • The manufacture and inspection of the EAST VS coil especially the joint for the SSMIC connection was described in detail. • The insulation resistances of all the VS coils have no significant reduction after endurance test. -- Abstract: In the ongoing latest update round of EAST (Experimental Advanced Superconducting Tokamak), two sets of two single-turn Vertical Stabilization (VS) coils were manufactured and installed symmetrically above and below the mid-plane in the vacuum vessel of EAST. The Stainless Steel Mineral Insulated Conductor (SSMIC) developed for ITER In-Vessel Coils (IVCs) in Institute of Plasma Physics, Chinese Academy of Science (ASIPP) was used for the EAST VS coils manufacture. Each turn poloidal field VS coil includes three internal joints in the vacuum vessel. The middle joint connects two pieces of conductor which together form an R2.3 m arc segment inside the vacuum vessel. The other two joints connect the arc segment with the two feeders near the port along the toroidal direction to bear lower electromagnetic loads during operation. Main processes and tests include material performances checking, conductor fabrication, joint connection and testing, coil forming, insulation performances measurement were described herein

ATF3, an HTLV-1 bZip factor binding protein, promotes proliferation of adult T-cell leukemia cells

Directory of Open Access Journals (Sweden)

Ohshima Koichi

2011-03-01

Full Text Available Abstract Background Adult T-cell leukemia (ATL is an aggressive malignancy of CD4+ T-cells caused by human T-cell leukemia virus type 1 (HTLV-1. The HTLV-1 bZIP factor (HBZ gene, which is encoded by the minus strand of the viral genome, is expressed as an antisense transcript in all ATL cases. By using yeast two-hybrid screening, we identified activating transcription factor 3 (ATF3 as an HBZ-interacting protein. ATF3 has been reported to be expressed in ATL cells, but its biological significance is not known. Results Immunoprecipitation analysis confirmed that ATF3 interacts with HBZ. Expression of ATF3 was upregulated in ATL cell lines and fresh ATL cases. Reporter assay revealed that ATF3 could interfere with the HTLV-1 Tax's transactivation of the 5' proviral long terminal repeat (LTR, doing so by affecting the ATF/CRE site, as well as HBZ. Suppressing ATF3 expression inhibited proliferation and strongly reduced the viability of ATL cells. As mechanisms of growth-promoting activity of ATF3, comparative expression profiling of ATF3 knockdown cells identified candidate genes that are critical for the cell cycle and cell death, including cell division cycle 2 (CDC2 and cyclin E2. ATF3 also enhanced p53 transcriptional activity, but this activity was suppressed by HBZ. Conclusions Thus, ATF3 expression has positive and negative effects on the proliferation and survival of ATL cells. HBZ impedes its negative effects, leaving ATF3 to promote proliferation of ATL cells via mechanisms including upregulation of CDC2 and cyclin E2. Both HBZ and ATF3 suppress Tax expression, which enables infected cells to escape the host immune system.

The loss of activating transcription factor 4 (ATF4) reduces bone toughness and fracture toughness.

Science.gov (United States)

Makowski, Alexander J; Uppuganti, Sasidhar; Wadeer, Sandra A; Whitehead, Jack M; Rowland, Barbara J; Granke, Mathilde; Mahadevan-Jansen, Anita; Yang, Xiangli; Nyman, Jeffry S

2014-05-01

Even though age-related changes to bone tissue affecting fracture risk are well characterized, only a few matrix-related factors have been identified as important to maintaining fracture resistance. As a gene critical to osteoblast differentiation, activating transcription factor 4 (ATF4) is possibly one of these important factors. To test the hypothesis that the loss of ATF4 affects the fracture resistance of bone beyond bone mass and structure, we harvested bones from Atf4+/+ and Atf4-/- littermates at 8 and 20 weeks of age (n≥9 per group) for bone assessment across several length scales. From whole bone mechanical tests in bending, femurs from Atf4-/- mice were found to be brittle with reduced toughness and fracture toughness compared to femurs from Atf4+/+ mice. However, there were no differences in material strength and in tissue hardness, as determined by nanoindentation, between the genotypes, irrespective of age. Tissue mineral density of the cortex at the point of loading as determined by micro-computed tomography was also not significantly different. However, by analyzing local composition by Raman Spectroscopy (RS), bone tissue of Atf4-/- mice was found to have higher mineral to collagen ratio compared to wild-type tissue, primarily at 20 weeks of age. From RS analysis of intact femurs at 2 orthogonal orientations relative to the polarization axis of the laser, we also found that the organizational-sensitive peak ratio, ν1Phosphate per Amide I, changed to a greater extent upon bone rotation for Atf4-deficient tissue, implying bone matrix organization may contribute to the brittleness phenotype. Target genes of ATF4 activity are not only important to osteoblast differentiation but also in maintaining bone toughness and fracture toughness. Published by Elsevier Inc.

The Loss of Activating Transcription Factor 4 (ATF4) Reduces Bone Toughness and Fracture Toughness

Science.gov (United States)

Makowski, Alexander J.; Uppuganti, Sasidhar; Waader, Sandra A.; Whitehead, Jack M.; Rowland, Barbara J.; Granke, Mathilde; Mahadevan-Jansen, Anita; Yang, Xiangli; Nyman, Jeffry S.

2014-01-01

Even though age-related changes to bone tissue affecting fracture risk are well characterized, only a few matrix-related factors have been identified as important to maintaining fracture resistance. As a gene critical to osteoblast differentiation, activating transcription factor 4 (ATF4) is possibly one of the seimportant factors. To test the hypothesis that the loss of ATF4 affects the fracture resistance of bone beyond bone mass and structure, we harvested bones from Atf4+/+ and Atf4−/− littermates at 8 and 20 weeks of age (n≥9 per group) for bone assessment across several length scales. From whole bone mechanical tests in bending, femurs from Atf4−/− mice were found to be brittle with reduced toughness and fracture toughness compared to femurs from Atf4+/+ mice. However, there were no differences in material strength and in tissue hardness, as determined by nanoindentation, between the genotypes, irrespective age. Tissue mineral density of the cortex at the point of loading as determined by micro-computed tomography was also not significantly different. However, by analyzing local composition by Raman Spectroscopy (RS), bone tissue of Atf4−/− mice was found to have higher mineral to collagen ratio compared to wild-type tissue, primarily at 20 weeks of age. From RS analysis of intact femurs at 2 orthogonal orientations relative to the polarization axis of the laser, we also found that the organizational-sensitive peak ratio, ν1 Phosphate per Amide I, changed to a greater extent upon bone rotation for Atf4-deficient tissue, implying bone matrix organization may contribute to the brittleness phenotype. Target genes of ATF4 activity are not only important to osteoblast differentiation but also maintaining bone toughness and fracture toughness. PMID:24509412

Selection of vacuum seals for EBT-P

International Nuclear Information System (INIS)

Dillow, C.F.; Adlon, G.L.; Stubblefield, V.E.

1981-01-01

Elmo Bumpy Torus Proof of Principle (EBT-P) is a magnetic fusion RandD facility being constructed by McDonnell Douglas Astronautics Company - St. Louis Division of Oak Ridge National Laboratory (ORNL). EBT-P is a truly unique fusion device requiring careful consideration in selecting both the primary vacuum seals on the toroidal vessel and the secondary vacuum seals in components such as vacuum pumps and and valves. The vacuum seal environment is described and the considerations in vacuum seal selection fully discussed. Methods for protecting vacuum seals in pumps and valves from the microwave environments are also presented

Integration test of ITER full-scale vacuum vessel sector

International Nuclear Information System (INIS)

Nakahira, M.; Koizumi, K.; Oka, K.

2001-01-01

The full-scale Sector Model Project, which was initiated in 1995 as one of the Large Seven R and D Projects, completed all R and D activities planned in the ITER-EDA period with the joint effort of the ITER Joint Central Team (JCT), the Japanese, the Russian Federation (RF) and the United States (US) Home Teams. The fabrication of a full-scale 18 toroidal sector, which is composed of two 9 sectors spliced at the port center, was successfully completed in September 1997 with the dimensional accuracy of ± 3 mm for the total height and total width. Both sectors were shipped to the test site in JAERI and the integration test was begun in October 1997. The integration test involves the adjustment of field joints, automatic Narrow Gap Tungsten Inert Gas (NG-TIG) welding of field joints with splice plates, and inspection of the joint by ultrasonic testing (UT), which are required for the initial assembly of ITER vacuum vessel. This first demonstration of field joint welding and performance test on the mechanical characteristics were completed in May 1998 and the all results obtained have satisfied the ITER design. In addition to these tests, the integration with the mid plane port extension fabricated by the Russian Home Team, and the cutting and re-welding test of field joints by using full-remotized welding and cutting system developed by the US Home Team, are planned as post EDA activities. (author)

Integration test of ITER full-scale vacuum vessel sector

International Nuclear Information System (INIS)

Nakahira, M.; Koizumi, K.; Oka, K.

1999-01-01

The full-scale Sector Model Project, which was initiated in 1995 as one of the Large Seven ITER R and D Projects, completed all R and D activities planned in the ITER-EDA period with the joint effort of the ITER Joint Central Team (JCT), the Japanese, the Russian Federation (RF) and the United States (US) Home Teams. The fabrication of a full-scale 18 toroidal sector, which is composed of two 9 sectors spliced at the port center, was successfully completed in September 1997 with the dimensional accuracy of - 3 mm for the total height and total width. Both sectors were shipped to the test site in JAERI and the integration test was begun in October 1997. The integration test involves the adjustment of field joints, automatic Narrow Gap Tungsten Inert Gas (NG-TIG) welding of field joints with splice plates, and inspection of the joint by ultrasonic testing (UT), which are required for the initial assembly of ITER vacuum vessel. This first demonstration of field joint welding and performance test on the mechanical characteristics were completed in May 1998 and the all results obtained have satisfied the ITER design. In addition to these tests, the integration with the mid plane port extension fabricated by the Russian Home Team, and the cutting and re-welding test of field joints by using full-remotized welding and cutting system developed by the US Home Team, are planned as post EDA activities. (author)

Development and control towards a parallel water hydraulic weld/cut robot for machining processes in ITER vacuum vessel

International Nuclear Information System (INIS)

Wu Huapeng; Handroos, Heikki; Pessi, Pekka; Kilkki, Juha; Jones, Lawrence

2005-01-01

This paper presents a special robot, able to carry out welding and machining processes from inside the ITER vacuum vessel (VV), consisting of a five degree-of-freedom parallel mechanism, mounted on a carriage driven by two electric motors on a rack. The kinematic design of the robot has been optimised for ITER access and a hydraulically actuated pre-prototype built. A hybrid controller is designed for the robot, including position, speed and pressure feedback loops to achieve high accuracy and high dynamic performances. Finally, the experimental tests are given and discussed

ATF2 spot size tuning using the rotation matrix

CERN Document Server

Scarfe, A; Jones, J K; Angal-Kalinin, D

2010-01-01

The Accelerator Test Facility (ATF2) at KEK aims to experimentally verify the local chromaticity correction scheme to achieve a vertical beam size of 37nm. The facility is a scaled down version of the final focus design proposed for the future linear colliders. In order to achieve this goal, high precision tuning methods are being developed. One of the methods proposed for ATF2 is a novel method known as the ‘rotation matrix’ method. Details of the development and testing of this method, including orthogonality optimisation and simulation methods, are presented.

Deflated-Victims of vacuum

International Nuclear Information System (INIS)

Sanders, Roy E.

2007-01-01

Atmospheric pressure combined with a partial vacuum within chemical plant or refinery tanks can result in some ego-deflating moments. This article will review three catastrophic vessel failures in detail and touch on several other incidents. A 4000-gal acid tank was destroyed by a siphoning action; a well maintained tank truck was destroyed during a routine delivery; and a large, brand new refinery mega-vessel collapsed as the steam within it condensed. Seasoned engineers are aware of the frail nature of tanks and provide safeguards or procedures to limit damages. The purpose of this paper is to ensure this new generation of chemical plant/refinery employees understand the problems of the past and take the necessary precautions to guard against tank damages created by partial vacuum conditions

Impacts of the Shine Through neutrals on the Vacuum Vessel of TJ-II during NBI

International Nuclear Information System (INIS)

Guasp, J.; Liniers, M.

1995-09-01

A numerical analysis of the impact patterns on the Vacuum Vessel produced by Shine through neutrals during the tangential balanced NBI in TJ-II Helical Axis Stellarator has been done. The results show two main concentrations. The first one the circular part of the Hard Core, near the zone of closest approach of the beam. The second one, the most important, around the beam exit, on the border between the plate of the HC cover and the sector wall. As expected, the Shine through loads decrease strongly with plasma density, predominating at low density at NBI start, decreasing quickly when density increases and increasing slightly with the beam energy. No overlapping with lost fast ions impacts is observed, that, in addition, show an opposite behaviour with density

In-vessel maintenance remote manipulator system

International Nuclear Information System (INIS)

Jimenez, E.

1978-01-01

The radiation environment within the Tokamak Fusion Test Reactor (TFTR) vacuum vessel necessitates the development of a Remote Manipulator System (RMS) to perform required periodic inspection and maintenance tasks. The RMS must be able to perform dexterous operations and handle loads that exceed human capabilities. The limited size of the access ports on the TFTR vacuum vessel and the performance profile, defined by the various handling requirements, present unique design constraints. The design approach and formulation of a RMS configuration which satisfies TFTR requirements is presented herein

The FONT5 Bunch-by-Bunch Position and Angle Feedback System at ATF2

Science.gov (United States)

Apsimon, R. J.; Bett, D. R.; Burrows, P. N.; Christian, G. B.; Constance, B.; Davis, M. R.; Gerbershagen, A.; Perry, C.; Resta-Lopez, J.

The FONT5 upstream beam-based feedback system at ATF2 is designed to correct the position and angle jitter at the entrance to the ATF2 final-focus system, and also to demonstrate a prototype intra-train feedback system for the International Linear Collider interaction point. We discuss the hardware, from stripline BPMs to kickers, and RF and digital signal processing, as well as presenting results from the latest beam tests at ATF2.

Design of large aperture, low mass vacuum windows

International Nuclear Information System (INIS)

Leonhardt, W.J.; Mapes, M.

1993-01-01

Large vacuum vessels are employed downstream of fixed targets in High Energy Physics experiments to provide a long path for particles to traverse without interacting with air molecules. These vessels generally have a large aperture opening known as a vacuum window which employs a thin membrane to preserve the vacuum environment yet allows the particles to pass through with a minimal effect on them. Several large windows have been built using a composite of Kevlar/Mylar including circular windows to a diameter of 96.5 cm and rectangular windows up to 193 cm x 86 cm. This paper describes the design, fabrication, testing and operating experience with these windows and relates the actual performance to theoretical predictions

ATF6α/β-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish.

Science.gov (United States)

Ishikawa, Tokiro; Okada, Tetsuya; Ishikawa-Fujiwara, Tomoko; Todo, Takeshi; Kamei, Yasuhiro; Shigenobu, Shuji; Tanaka, Minoru; Saito, Taro L; Yoshimura, Jun; Morishita, Shinichi; Toyoda, Atsushi; Sakaki, Yoshiyuki; Taniguchi, Yoshihito; Takeda, Shunichi; Mori, Kazutoshi

2013-05-01

ATF6α and ATF6β are membrane-bound transcription factors activated by regulated intramembrane proteolysis in response to endoplasmic reticulum (ER) stress to induce various ER quality control proteins. ATF6α- and ATF6β single-knockout mice develop normally, but ATF6α/β double knockout causes embryonic lethality, the reason for which is unknown. Here we show in medaka fish that ATF6α is primarily responsible for transcriptional induction of the major ER chaperone BiP and that ATF6α/β double knockout, but not ATF6α- or ATF6β single knockout, causes embryonic lethality, as in mice. Analyses of ER stress reporters reveal that ER stress occurs physiologically during medaka early embryonic development, particularly in the brain, otic vesicle, and notochord, resulting in ATF6α- and ATF6β-mediated induction of BiP, and that knockdown of the α1 chain of type VIII collagen reduces such ER stress. The absence of transcriptional induction of several ER chaperones in ATF6α/β double knockout causes more profound ER stress and impaired notochord development, which is partially rescued by overexpression of BiP. Thus ATF6α/β-mediated adjustment of chaperone levels to increased demands in the ER is essential for development of the notochord, which synthesizes and secretes large amounts of extracellular matrix proteins to serve as the body axis before formation of the vertebra.

Rationalization and utilization of double-wall vacuum vessel for tokamak fusion facility

International Nuclear Information System (INIS)

Nakahira, Masataka

2005-09-01

Vacuum Vessel (VV) of ITER is difficult to apply a non-destructive in-service inspection (ISI) and then new safety concept is needed. Present fabrication standards are not applicable to the VV, because the access is limited to the backside of closure weld of double wall. Fabrication tolerance of VV is ± 5mm even the structure is huge as high as 10m. This accuracy requires a rational method on the estimation of welding deformation. In this report, an inherent safety feature of the tokamak is proved closing up a special characteristic of termination of fusion reaction due to tiny water leak. A rational concept not to require ISI without sacrificing safety is shown based on this result. A partial penetration T-welded joint is proposed to establish a rational fabrication method of double wall. Strength and susceptibility to crevice corrosion is evaluated for this joint and feasibility is confirmed. A rational method of estimation of welding deformation for large and complex structure is proposed and the efficiency is shown by comparing analysis and experimental results of full-scale test. (author)

Impacts of the CX neutrals on the Vacuum Vessel of TJ-II during NBI

International Nuclear Information System (INIS)

Guasp, J.

1995-01-01

A numerical analysis of the impact patterns on the Vacuum Vessel produced by CX neutrals during the tangential balanced NBI in TJ-II Helical Axis Stellarator has been done. The results show periodical distributions with smooth maxima and mild loads, concentrated preferential on the HC plates. A certain preference of these neutral to emerge down wards from the plasma appears, as a consequence of a similar trend for the trapped particles. The differences between the impacts produced by the beam parallel to the magnetic field and the opposite one are small, once more as a consequence of the loss of memory of trapped particles to initial direction. The dependence of loads with plasma density and beam energy follows the trend of CX losses, decreasing strongly with increasing density and decreasing, more smoothly, with energy. (Author) 3 refs

The cellular transcription factor CREB corresponds to activating transcription factor 47 (ATF-47) and forms complexes with a group of polypeptides related to ATF-43.

OpenAIRE

Hurst, H C; Masson, N; Jones, N C; Lee, K A

1990-01-01

Promoter elements containing the sequence motif CGTCA are important for a variety of inducible responses at the transcriptional level. Multiple cellular factors specifically bind to these elements and are encoded by a multigene family. Among these factors, polypeptides termed activating transcription factor 43 (ATF-43) and ATF-47 have been purified from HeLa cells and a factor referred to as cyclic AMP response element-binding protein (CREB) has been isolated from PC12 cells and rat brain. We...

Metallurgy of steels for PWR pressure vessels

International Nuclear Information System (INIS)

Kepka, M.; Mocek, J.; Barackova, L.

1980-01-01

A survey and the chemical compositions are presented of reactor pressure vessel steels. The metallurgy is described of steel making for pressure vessels in Japan and the USSR. Both acidic and alkaline open-hearth steel is used for the manufacture of ingots. The leading world manufacturers of forging ingots for pressure vessels, however, exclusively use electric steel. Vacuum casting techniques are exclusively used. Experience is shown gained with the introduction of the manufacture of forging ingots for pressure vessels at SKODA, Plzen. The metallurgical procedure was tested utilizing alkaline open hearths, electric arc furnaces and facilities for vacuum casting of steel. Pure charge raw materials should be used for securing high steel purity. Prior to forging pressure vessel rings, not only should sufficiently big bottoms and heads be removed but also the ingot middle part should be scrapped showing higher contents of impurities and nonhomogeneous structure. (B.S.)

Metallurgy of steels for PWR pressure vessels

Energy Technology Data Exchange (ETDEWEB)

Kepka, M; Mocek, J; Barackova, L [Skoda, Plzen (Czechoslovakia)

1980-09-01

A survey and the chemical compositions are presented of reactor pressure vessel steels. The metallurgy is described of steel making for pressure vessels in Japan and the USSR. Both acidic and alkaline open-hearth steel is used for the manufacture of ingots. The leading world manufacturers of forging ingots for pressure vessels, however, exclusively use electric steel. Vacuum casting techniques are exclusively used. Experience is shown gained with the introduction of the manufacture of forging ingots for pressure vessels at SKODA, Plzen. The metallurgical procedure was tested utilizing alkaline open hearths, electric arc furnaces and facilities for vacuum casting of steel. Pure charge raw materials should be used for securing high steel purity. Prior to forging pressure vessel rings, not only should sufficiently big bottoms and heads be removed but also the ingot middle part should be scrapped showing higher contents of impurities and nonhomogeneous structure.

Engineering analysis of ITER In-Vessel Viewing System guide tube

Energy Technology Data Exchange (ETDEWEB)

Casal, Natalia, E-mail: natalia.casal@iter.org [ITER Organization, Route de Vinon sur Verdon, St Paul-lez-Durance (France); Bates, Philip [Fusion for Energy, Barcelona (Spain); Bede, Ottó [Oxford Technologies Ltd., Abingdon (United Kingdom); Damiani, Carlo; Dubus, Gregory [Fusion for Energy, Barcelona (Spain); Omran, Hassan [Oxford Technologies Ltd., Abingdon (United Kingdom); Palmer, Jim [ITER Organization, Route de Vinon sur Verdon, St Paul-lez-Durance (France); Puiu, Adrian [Fusion for Energy, Barcelona (Spain); Reichle, Roger; Suárez, Alejandro; Walker, Christopher; Walsh, Michael [ITER Organization, Route de Vinon sur Verdon, St Paul-lez-Durance (France)

2015-10-15

Highlights: • Conceptual design of IVVS Loads action on IVVS Dominant loads. • Seismic and baking conditions. • No active cooling needed for IVVS. • IVVS requires additional support points to avoid excessive deformation. - Abstract: The In Vessel Viewing System (IVVS) will be one of the essential machine diagnostic systems at ITER to provide information about the status of in-vessel and plasma facing components and to evaluate the dust inside the Vacuum Vessel. The current design consists of six scanning probes and their deployment systems, which are placed in dedicated ports at the divertor level. These units are located in resident guiding tubes 10 m long, which allow the IVVS probes to go from their storage location to the scanning position by means of a simple straight translation. Moreover, each resident tube is supported inside the corresponding Vacuum Vessel and Cryostat port extensions, which are part of the primary confinement barrier. As the Vacuum Vessel and the Cryostat will move with respect to each other during operation (especially during baking) and during incidents and accidents (disruptions, vertical displacement events, seismic events), the structural integrity of the resident tube and the surrounding vacuum boundaries would be compromised if the required flexibility and supports are not appropriately assured. This paper focuses on the integration of the present design of the IVVS into the Vacuum Vessel and Cryostat environment. It presents the adopted strategy to withstand all the main interfacing loads without damaging the confinement barriers and the corresponding analysis supporting it.

Design and performance of main vacuum pumping system of SST-1 Tokamak

Energy Technology Data Exchange (ETDEWEB)

Khan, Ziauddin, E-mail: ziauddin@ipr.res.in; Pathan, Firozkhan; George, Siju; Dhanani, Kalpesh; Paravastu, Yuvakiran; Semwal, Pratibha; Pradhan, Subrata

2014-01-15

Highlights: •SST-1 Tokamak was successfully commissioned. •Vacuum vessel and cryostat were pumped down to 6.3 × 10{sup −7} mbar and 1.3 × 10{sup −5} mbar. •Leaks developed during baking were detected in-situ by RGA and confirmed later on. •Cryo-pumping effect was observed when LN2 thermal shields reached below 273 K. •Non-standard aluminum wire-seals have shown leak tightness < 1.0 × 10{sup −9} mbar l/s. -- Abstract: Steady-state Superconducting Tokamak (SST-1) was installed and it is commissioning for overall vacuum integrity, magnet systems functionality in terms of successful cool down to 4.5 K and charging up to 10 kA current was started from August 2012. Plasma operation of 100 kA current for more than 100 ms was also envisaged. It is comprised of vacuum vessel (VV) and cryostat (CST). Vacuum vessel, an ultra-high (UHV) vacuum chamber with net volume of 23 m{sup 3} was maintained at the base pressure of 6.3 × 10{sup −7} mbar for plasma confinement. Cryostat, a high-vacuum (HV) chamber with empty volume 39 m{sup 3} housing superconducting magnet system, bubble thermal shields and hydraulics for these circuits, maintained at 1.3 × 10{sup −5} mbar in order to provide suitable environment for these components. In order to achieve these ultimate vacuums, two numbers of turbo-molecular pumps (TMP) are installed in vacuum vessel while three numbers of turbo-molecular pumps are installed in cryostat. Initial pumping of both the chambers was carried out by using suitable Roots pumps. PXI based real time controlled system is used for remote operation of the complete pumping operation. In order to achieve UHV inside the vacuum vessel, it was baked at 150 °C for longer duration. Aluminum wire-seals were used for all non-circular demountable ports and a leak tightness < 1.0 × 10{sup −9} mbar l/s were achieved.

Elmo Bumpy Torus proof of principle, Phase II: Title 1 report. Volume II. Toroidal vessel

International Nuclear Information System (INIS)

1982-01-01

The Toroidal Vessel provides the vacuum enclosure for containing the high temperature steady state plasma. In addition, the Toroidal Vessel must provide several viewing ports for plasma diagnostics, vacuum pumping ports for both high vacuum and roughing vacuum, feed-through ports for ECRH waveguides, limiter feed throughs for cooling and supporting the limiters, and ports for ion gages. The vessel must operate in an intense environment comprised of x-rays, microwaves, magnetic fields and plasma heat loads as well as the atmosphere pressure and gravity loads and the internal thermal stress loads due to heating and cooling of the torus. A key issue addressed was the choice of vacuum vessel seal and wall materials. In addition, during the course of the study, ORNL requested that horsecollar diagnostic ports be incorporated in the design. A comprehensive trade study was performed considering the vessel material issues in concert with the impact of the horsecollar port design. A change in baseline from an aluminum vessel with elastomer seals and circular diagnostic ports to austenitic stainless steel vessel with metal seals and horsecollar ports was agreed upon by both MDAC and ORNL towards the end of Title I

F4E R and D programme and results on in-vessel dust and tritium

International Nuclear Information System (INIS)

Le Guern, F.; Gulden, W.; Ciattaglia, S.; Counsell, G.; Bengaouer, A.; Brinster, J.; Dabbene, F.; Denkevitz, A.; Jordan, T.; Kuznetsov, M.; Porfiri, M.T.; Redlinger, R.; Roblin, Ph.; Roth, J.; Segre, J.; Sugiyama, K.; Tkatschenko, I.; Xu, Z.

2011-01-01

In a Tokamak vacuum vessel, plasma-wall interactions can result in the production of radioactive dust and H isotopes (including tritium) can be trapped both in in-vessel material and in dust. The vacuum vessel represents the most important confinement barrier to this radioactive material. In the event of an accident involving ingress of steam to the vacuum vessel, hydrogen could be produced by chemical reactions with hot metal and dust. Hydrogen isotopes could also be desorbed from in-vessel components, e.g. cryopumps. In events where an ingress of air to the vacuum vessel occurs, reaction of the air with hydrogen and/or dust therefore cannot be completely excluded. Due to the radiological risks highlighted by the safety evaluation studies for ITER in normal conditions (e.g. in-vessel maintenance chronic release) and accidental ones (e.g. challenge of vacuum vessel tightness in the event of a hydrogen/dust explosion with air), limitations on the accumulation of dust and tritium in the vacuum vessel are imposed as well as controls over the maximum extent of the quantity of accidental air ingress. ITER IO has defined a strategy for the control of in-vessel dust and tritium inventories below the safety limits based primarily on the measurement and removal of dust and tritium. In this context, this paper will report on the efforts under F4E responsibility to develop a number of the new ITER baseline systems. In particular this paper, after a review of safety constraints and ITER strategy, provides the status of: (1) tasks being launched on diagnostics for in-vessel dust inventory measurement, (2) experiments to enrich the data about the effectiveness of desorption of tritium from Be at 350 o C (divertor baking aiming to release significant amount of tritium trapped in Be co-deposit), (3) on-going R and D programme (experimental and numerical simulation) at FZK, CEA and ENEA on in-vacuum vessel H2 dust explosion.

Impacts of the Shine Through neutrals on the Vacuum Vessel of TJ-II during NBI

International Nuclear Information System (INIS)

Guasp, J.; Liniers, M.

1995-01-01

A numerical analysis of the impact patterns on the Vacuum Vessel produced by Shine Through neutrals during the tangential balanced NBI in TJ-II Helical Axis Stellarator has been done. The results show two main concentrations. The first one the circular part of the Hard Core, near the zone of closest approach of the beam. The second one, the most important, around the beam exit, on the border between the plate of the HC cover and the sector wall. As expected, the Shine Through loads decrease strongly with plasma density, predominating at low density at NBI start, decreasing quickly when density increases and increasing slightly with the beam energy. No overlapping with lost fast ions impacts is observed, that, in addition, show an opposite behaviour with density. (Author) 3 refs

Design of large aperture, low mass vacuum windows

International Nuclear Information System (INIS)

Leonhardt, W.J.; Mapes, M.

1993-01-01

Large vacuum vessels are employed downstream of fixed targets in High Energy Physics experiments to provide a long path for particles to transverse without interacting with air molecules. These vessels generally have a large aperture opening known as a open-quotes vacuum windowclose quotes which employs a thin membrane to preserve the vacuum environment yet allows the particles to pass through with a minimal effect on them. Several large windows have been built using a composite of Kevlar/Mylar including circular windows to a diameter of 96.5 cm and rectangular windows up to 193 cm x 86 cm. This paper describes the design, fabrication, testing and operating experience with these windows and relates the actual performance to theoretical predictions

Saccharomyces cerevisiae Atf1p is an alcohol acetyltransferase and a thioesterase in vitro.

Science.gov (United States)

Nancolas, Bethany; Bull, Ian D; Stenner, Richard; Dufour, Virginie; Curnow, Paul

2017-06-01

The alcohol-O-acyltransferases are bisubstrate enzymes that catalyse the transfer of acyl chains from an acyl-coenzyme A (CoA) donor to an acceptor alcohol. In the industrial yeast Saccharomyces cerevisiae this reaction produces acyl esters that are an important influence on the flavour of fermented beverages and foods. There is also a growing interest in using acyltransferases to produce bulk quantities of acyl esters in engineered microbial cell factories. However, the structure and function of the alcohol-O-acyltransferases remain only partly understood. Here, we recombinantly express, purify and characterize Atf1p, the major alcohol acetyltransferase from S. cerevisiae. We find that Atf1p is promiscuous with regard to the alcohol cosubstrate but that the acyltransfer activity is specific for acetyl-CoA. Additionally, we find that Atf1p is an efficient thioesterase in vitro with specificity towards medium-chain-length acyl-CoAs. Unexpectedly, we also find that mutating the supposed catalytic histidine (H191) within the conserved HXXXDG active site motif only moderately reduces the thioesterase activity of Atf1p. Our results imply a role for Atf1p in CoA homeostasis and suggest that engineering Atf1p to reduce the thioesterase activity could improve product yields of acetate esters from cellular factories. © 2017 The Authors. Yeast published by John Wiley & Sons, Ltd. © 2017 The Authors. Yeast published by John Wiley & Sons, Ltd.

Design and structural analysis of support structure for ITER vacuum vessel

International Nuclear Information System (INIS)

Takeda, Nobukazu; Ohmori, Junji; Nakahira, Masataka; Shibanuma, Kiyoshi

2004-01-01

The International Thermonuclear Experimental Reactor (ITER) vacuum vessel (VV) is a safety component confining radioactive materials such as tritium and activated dust. An independent VV support structure with multiple flexible plates located at the bottom of VV lower port is proposed as a new concept, which is deferent from the current design, i.e., the VV support is directly connected to the toroidal coils (TF coils). This independent concept has two advantages comparing to the current one: (1) thermal load due to the temperature deference between VV and TF coils becomes lower and (2) the TF coils are categorized as non-safety components because of its independence from VV. Stress Analyses have been performed to assess the integrity of the VV support structure using a precisely modeled VV structure. As a result, (1) the maximum displacement of the VV corresponding to the relative displacement between VV and TF coils is found to be 15 mm, much less than the current design clearance of 100 mm, and (2) the stresses of the whole VV system including VV support are estimated to be less than the allowable ones defined by ASME Section III Subsection NF, respectively. Based on these assessments, the feasibility of the proposed independent VV support has been verified as a VV support. (author)

ATF3 upregulation in glia during Wallerian degeneration: differential expression in peripheral nerves and CNS white matter

Directory of Open Access Journals (Sweden)

Coffin Robert S

2004-03-01

Full Text Available Abstract Background Many changes in gene expression occur in distal stumps of injured nerves but the transcriptional control of these events is poorly understood. We have examined the expression of the transcription factors ATF3 and c-Jun by non-neuronal cells during Wallerian degeneration following injury to sciatic nerves, dorsal roots and optic nerves of rats and mice, using immunohistochemistry and in situ hybridization. Results Following sciatic nerve injury – transection or transection and reanastomosis – ATF3 was strongly upregulated by endoneurial, but not perineurial cells, of the distal stumps of the nerves by 1 day post operation (dpo and remained strongly expressed in the endoneurium at 30 dpo when axonal regeneration was prevented. Most ATF3+ cells were immunoreactive for the Schwann cell marker, S100. When the nerve was transected and reanastomosed, allowing regeneration of axons, most ATF3 expression had been downregulated by 30 dpo. ATF3 expression was weaker in the proximal stumps of the injured nerves than in the distal stumps and present in fewer cells at all times after injury. ATF3 was upregulated by endoneurial cells in the distal stumps of injured neonatal rat sciatic nerves, but more weakly than in adult animals. ATF3 expression in transected sciatic nerves of mice was similar to that in rats. Following dorsal root injury in adult rats, ATF3 was upregulated in the part of the root between the lesion and the spinal cord (containing Schwann cells, beginning at 1 dpo, but not in the dorsal root entry zone or in the degenerating dorsal column of the spinal cord. Following optic nerve crush in adult rats, ATF3 was found in some cells at the injury site and small numbers of cells within the optic nerve displayed weak immunoreactivity. The pattern of expression of c-Jun in all types of nerve injury was similar to that of ATF3. Conclusion These findings raise the possibility that ATF3/c-Jun heterodimers may play a role in

Development of the C-Band BPM System for ATF2

CERN Document Server

Lyapin, A; Wing, M; Shin, S; Honda, Y; Tauchi, T; Terunuma, N; Heo, A; Kim, E; Kim, K; Ainsworth, R C E; Boogert, S T; Boorman, G; Molloy, S; McCormick, D; Nelson, J; White, G; Ward, D

2010-01-01

The ATF2 international collaboration is intending to demonstrate nanometre beam sizes required for the future Linear Colliders. An essential part of the beam diagnostics needed to achieve that goal is the high resolution cavity beam position monitors (BPMs). In this paper we report on the C-band system consisting of 32 BPMs spread over the whole length of the new ATF2 extraction beamline. We discuss the design of the BPMs and electronics, main features of the DAQ system, and the first operational experience with these BPMs.

ATF4, A Novel Mediator of the Anabolic Actions of PTH on Bone

Science.gov (United States)

2008-07-01

pathways. Lastly, PTH stimulation of Ocn expres- sion was lost by silent interfering RNA down-regulation of ATF4 in MC-4 cells and Atf4/ bone marrow...M 2000 Para- thyroid hormone-related protein downregulates bone sialoprotein gene ex- pression in cementoblasts: role of the protein kinase A pathway

Vacuum boundary modifications of the RFX-mod machine

Energy Technology Data Exchange (ETDEWEB)

Patel, Nisarg, E-mail: nisarg.patel@igi.cnr.it [University of Padova,Via 8 Febbraio 2, Padova 35122 (Italy); Consorzio RFX, Corso StatiUniti 4, Padova 35127 (Italy); Dalla Palma, Mauro; Dal Bello, Samuele; Grando, Luca; Peruzzo, Simone [Consorzio RFX, Corso StatiUniti 4, Padova 35127 (Italy); Sonato, Piergiorgio [University of Padova,Via 8 Febbraio 2, Padova 35122 (Italy); Consorzio RFX, Corso StatiUniti 4, Padova 35127 (Italy)

2016-11-01

Highlights: • Different vacuum sealing solutions are designed for cuts of Toroidal Support Structure. • New supporting rings are designed for In-TSS components. • Identified integration of the sub-assemblies. • Thermo-mechanical behaviour of components are verified against standard design rules. - Abstract: The results produced by experimental campaigns of RFX-mod shows the need to improve passive MHD control and minimise braking torque on plasma. These improvements require major mechanical changes on the present components of the machine including first wall, vacuum vessel, and toroidal support structure (TSS). The vacuum vessel will be removed and the first wall tiles will be directly supported by the passive stabilising shell, so increasing the poloidal cross section by 28 mm radially and bringing the passive stabilising shell as close as possible to the plasma boundary. This paper presents the mechanical design modifications of the torus assembly. Composite rings are designed to support the passive stabilising shell on the TSS. The vacuum boundary is shifted at the TSS by developing different joint solutions compatible with the stringent requirements of the present components: ceramic-metal brazed rings at the two poloidal joints, fully welded solution at the external equatorial joint, and resistive weld plate at the internal equatorial joint. The vacuum vessel portholes for pumping, fuelling, diagnostics, and sensor cable routing are redesigned to be integrated onto the TSS. The design is supported by thermo-mechanical analyses and verifications carried out applying load combinations corresponding to the expected load cases.

Lipopolysaccharide preconditioning protects hepatocytes from ischemia/reperfusion injury (IRI through inhibiting ATF4-CHOP pathway in mice.

Directory of Open Access Journals (Sweden)

Jianhua Rao

Full Text Available BACKGROUND: Low-dose lipopolysaccharide (LPS preconditioning-induced liver protection has been demonstrated during ischemia-reperfusion injury (IRI in several organs but has not been sufficiently elucidated underlying causal mechanism. This study investigated the role of low-dose LPS preconditioning on ATF4-CHOP pathway as well as the effects of the pathway on tissue injury and inflammation in a mouse model of liver partial-warm IRI. METHODS: LPS (100 µg/kg/d was injected intraperitoneally two days before ischemia. Hepatic injury was evaluated based on serum alanine aminotransferase levels, histopathology, and caspase-3 activity. The ATF4-CHOP pathway and its related apoptotic molecules were investigated after reperfusion. The role of LPS preconditioning on apoptosis and ATF4-CHOP pathway was examined in vitro. Moreover, the effects of the ATF4-CHOP pathway on apoptosis, Caspase-12, and Caspase-3 were determined with ATF4 small interfering RNA (siRNA. Inflammatory cytokine expression was also checked after reperfusion. Inflammatory cytokines and related signaling pathways were analyzed in vitro in macrophages treated by LPS preconditioning or ATF4 siRNA. RESULTS: LPS preconditioning significantly attenuated liver injury after IRI. As demonstrated by in vitro experiments, LPS preconditioning significantly reduced the upregulation of the ATF4-CHOP pathway and inhibited Caspase-12 and Caspase-3 activation after IRI. Later experiments showed that ATF4 knockdown significantly suppressed CHOP, cleaved caspase-12 and caspase-3 expression, as well as inhibited hepatocellular apoptosis. In addition, in mice pretreated with LPS, TNF-α and IL-6 were inhibited after reperfusion, whereas IL-10 was upregulated. Similarly, low-dose LPS significantly inhibited TNF-α, IL-6, ATF4-CHOP pathway, NF-κB pathway, and ERK1/2 in high-dose LPS-stimulated macrophages, whereas IL-10 and cytokine signaling (SOCS-3 suppressor were induced. Importantly, ATF4 siRNA is

Effects of limiter biasing on the ATF torsatron

International Nuclear Information System (INIS)

Uckan, T.; Baylor, L.R.; Bell, J.D.; Bigelow, T.S.; England, A.C.; Harris, J.H.; Isler, R.C.; Jernigan, T.C.; Lyon, J.F.; Ma, C.H.; Mioduszewski, P.K.; Murakami, M.; Rasmussen, D.A.; Wilgen, J.B.; Aceto, S.C.; Zielinski, J.J.

1992-09-01

Positive limiter biasing on the currentless Advanced Toroidal Facility (ATF) torsatron produces a significant increase in the particle confinement with no improvement in the energy confinement. Experiments have been carried out in 1-T plasmas with ∼400 kill of electron cyclotron heating ECM. Two rail limiters located at the last closed flux surface (LCFS), one at the top and one at the bottom of the device, are biased at positive and negative potentials with respect to the vessel. When the limiters are positively biased at up to 300 V, the density increases sharply to the ECH cutoff value. At the same time, the H α radiation drops, indicating that the particle confinement improves. When the density is kept constant, the H α radiation is further reduced and there is almost no change in the plasma stored energy. Under these conditions, the density profile becomes peaked and the electric field becomes outward-pointing outside the LCFS and more negative inside the LCFS. In contrast, negative biasing yields some reduction of the density and stored energy at constant gas feed, and the plasma potential profile remains the same. Biasing has almost no effect on the intrinsic impurity levels in the plasma

Expanded Fermilab pressure vessel directory program

Energy Technology Data Exchange (ETDEWEB)

Tanner, A.

1983-01-01

Several procedures have been written to manage the information pertaining to the vacuum tanks and pressure vessels for which the laboratory is responsible. These procedures have been named TANK1 for the vessels belonging to the Accelerator Division, TANK2 and TANK3 for the vessels belonging to the Research Division and to Technical Support respectively, and TANK4 for the vessels belonging to the Business Division. The operating procedures are otherwise identical in every respect.

Expanded Fermilab pressure vessel directory program

International Nuclear Information System (INIS)

Tanner, A.

1983-01-01

Several procedures have been written to manage the information pertaining to the vacuum tanks and pressure vessels for which the laboratory is responsible. These procedures have been named TANK1 for the vessels belonging to the Accelerator Division, TANK2 and TANK3 for the vessels belonging to the Research Division and to Technical Support respectively, and TANK4 for the vessels belonging to the Business Division. The operating procedures are otherwise identical in every respect

Vacuum technologies developed for at-400A Type B transportation and storage package

International Nuclear Information System (INIS)

Franklin, K.W.; Cockrell, G.D.

1995-01-01

The AT-400A TYPE B transportation and storage container will be used at Pantex Plant for the transportation and interim storage of plutonium pits. The AT-400A was designed by a joint effort between Sandia National Labs, Los Alamos National Labs, Lawrence Livermore National Laboratory, and Mason and Hanger-Silas Mason Co., Inc. In order to meet the requirements for transportation and storage, five different vacuum technologies had to be developed. The goals of the various vacuum technologies were to verify the plutonium pit was sealed, perform the assembly verification leak check in accordance with ANSI N-14.5 and to provide a final inert gas backfill in the containment vessel. This paper will discuss the following five vacuum technologies: (1) Pit Leak Testing, (2) Containment Vessel Purge and Backfill with tracer gas, (3) Containment Vessel Leak Testing, (4) Containment Vessel Purge and Final Backfill, and (5) Leak Testing of the Containment Vessel Gas Transfer tube

C/EBPγ Is a Critical Regulator of Cellular Stress Response Networks through Heterodimerization with ATF4

Science.gov (United States)

Huggins, Christopher J.; Mayekar, Manasi K.; Martin, Nancy; Saylor, Karen L.; Gonit, Mesfin; Jailwala, Parthav; Kasoji, Manjula; Haines, Diana C.; Quiñones, Octavio A.

2015-01-01

The integrated stress response (ISR) controls cellular adaptations to nutrient deprivation, redox imbalances, and endoplasmic reticulum (ER) stress. ISR genes are upregulated in stressed cells, primarily by the bZIP transcription factor ATF4 through its recruitment to cis-regulatory C/EBP:ATF response elements (CAREs) together with a dimeric partner of uncertain identity. Here, we show that C/EBPγ:ATF4 heterodimers, but not C/EBPβ:ATF4 dimers, are the predominant CARE-binding species in stressed cells. C/EBPγ and ATF4 associate with genomic CAREs in a mutually dependent manner and coregulate many ISR genes. In contrast, the C/EBP family members C/EBPβ and C/EBP homologous protein (CHOP) were largely dispensable for induction of stress genes. Cebpg−/− mouse embryonic fibroblasts (MEFs) proliferate poorly and exhibit oxidative stress due to reduced glutathione levels and impaired expression of several glutathione biosynthesis pathway genes. Cebpg−/− mice (C57BL/6 background) display reduced body size and microphthalmia, similar to ATF4-null animals. In addition, C/EBPγ-deficient newborns die from atelectasis and respiratory failure, which can be mitigated by in utero exposure to the antioxidant, N-acetyl-cysteine. Cebpg−/− mice on a mixed strain background showed improved viability but, upon aging, developed significantly fewer malignant solid tumors than WT animals. Our findings identify C/EBPγ as a novel antioxidant regulator and an obligatory ATF4 partner that controls redox homeostasis in normal and cancerous cells. PMID:26667036

Test of an undulated vacuum chamber for the ISR

CERN Multimedia

1975-01-01

This picture shows mechanical tests of an undulated vacuum chamber for downstream arms of ISR intersections. This chamber, made of 0.3 mm thick inconel, had inner dimensions of 150 mm by 50 mm. The deflection under vacuum is measured by dial gauges. On the left one sees the large vessel where vacuum chambers were tested at pressures above atmospheric pressure.

Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene

Science.gov (United States)

Maekawa, Toshio; Kim, Seungjoon; Nakai, Daisuke; Makino, Chieko; Takagi, Tsuyoshi; Ogura, Hiroo; Yamada, Kazuyuki; Chatton, Bruno; Ishii, Shunsuke

2010-01-01

Many symptoms induced by isolation rearing of rodents may be relevant to neuropsychiatric disorders, including depression. However, identities of transcription factors that regulate gene expression in response to chronic social isolation stress remain elusive. The transcription factor ATF-7 is structurally related to ATF-2, which is activated by various stresses, including inflammatory cytokines. Here, we report that Atf-7-deficient mice exhibit abnormal behaviours and increased 5-HT receptor 5B (Htr5b) mRNA levels in the dorsal raphe nuclei. ATF-7 silences the transcription of Htr5B by directly binding to its 5′-regulatory region, and mediates histone H3-K9 trimethylation via interaction with the ESET histone methyltransferase. Isolation-reared wild-type (WT) mice exhibit abnormal behaviours that resemble those of Atf-7-deficient mice. Upon social isolation stress, ATF-7 in the dorsal raphe nucleus is phosphorylated via p38 and is released from the Htr5b promoter, leading to the upregulation of Htr5b. Thus, ATF-7 may have a critical role in gene expression induced by social isolation stress. PMID:19893493

Isoproterenol Increases RANKL Expression in a ATF4/NFATc1-Dependent Manner in Mouse Osteoblastic Cells

Directory of Open Access Journals (Sweden)

Kyunghwa Baek

2017-10-01

Full Text Available Sympathetic nervous system stimulation-induced β-adrenergic signal transduction is known to induce bone loss and increase of osteoclast activity. Although isoproterenol, a nonspecific β-adrenergic receptor agonist, has been shown to increase receptor activator of NF-κB ligand (RANKL, the details of the regulatory mechanisms remain unclear. In the present study, we investigated the role of the nuclear factor of activated T-cells (NFAT in isoproterenol-induced RANKL expression in C2C12 and in primary cultured mouse calvarial cells. Isoproterenol increased nuclear factor of activated T-cells cytoplasmic 1 (NFATc1 and RANKL expressions at both mRNA and protein levels and increased NFAT reporter activity. NFATc1 knockdown blocked isoproterenol-mediated RANKL expression. Isoproterenol also promoted cAMP response element-binding protein 1 (CREB1 and activating transcription factor 4 (ATF4 phosphorylation. Isoproterenol-mediated transcriptional activation of NFAT was blocked by protein kinase A (PKA inhibitor H89. Isoproterenol-induced CREB1, ATF4, NFATc1, and RANKL expressions were suppressed by H89. Mutations in cAMP response element-like or NFAT-binding element suppressed isoproterenol-induced RANKL promoter activity. Chromatin immunoprecipitation analysis demonstrated that isoproterenol increased NFAT-binding and ATF4-binding activities on the mouse RANKL promoter, but did not increase CREB1-binding activity. Association of NFATc1 and ATF4 was not observed in a co-immunoprecipitation study. ATF4 knockdown suppressed isoproterenol-induced NFAT binding to the RANKL promoter, whereas NFATc1 knockdown did not suppress isoproterenol-induced ATF4 binding to the RANKL promoter. ATF4 knockdown suppressed isoproterenol-induced expressions of NFATc1 and RANKL. These results suggest that isoproterenol increases RANKL expression in an ATF4/NFATc1-dependent manner.

20 CFR 655.520 - Special provisions regarding automated vessels.

Science.gov (United States)

2010-04-01

... longshore work consisting of the use of automated self-unloading conveyor belt or vacuum-actuated systems on... use of automated self-unloading conveyor belt or vacuum-actuated equipment at the particular port...-unloading conveyor belt or vacuum-actuated systems on a vessel is the prevailing practice at a particular...

Basic experiments during loss of vacuum event (LOVE) in fusion experimental reactor

International Nuclear Information System (INIS)

Ogawa, Masuro; Kunugi, Tomoaki; Seki, Yasushi

1993-01-01

If a loss of vacuum event (LOVE) occurs due to damage of the vacuum vessel of a nuclear fusion experimental reactor, some chemical reactions such as a graphic oxidation and a buoyancy-driven exchange flow take place after equalization of the gas pressure between the inside and outside of the vacuum vessel. The graphite oxidation would generate inflammable carbon monoxide and release tritium retained in the graphite. The exchange flow through the breaches may transport the carbon monoxide and tritium out of the vacuum vessel. To add confidence to the safety evaluations and analyses, it is important to grasp the basic phenomena such as the exchange flow and the graphite oxidation. Experiments of the exchange flow and the graphite oxidation were carried out to obtain the exchange flow rate and the rate constant for the carbon monoxide combustion, respectively. These experimental results were compared with existing correlations. The authors plan a scaled-model test and a full-scale model test for the LOVE

Beam-based alignment at the KEK-ATF damping ring

International Nuclear Information System (INIS)

Woodley, Mark D.; Nelson, Janice; Ross, Marc; Turner, James; Wolski, A.; Kubo, Kiyoshi

2004-01-01

The damping rings of a future linear collider will have demanding alignment and stability requirements in order to achieve the low vertical emittance necessary for high luminosity. The Accelerator Test Facility (ATF) at KEK has successfully demonstrated the vertical emittance below 5 pm that is specified for the GLC/NLC Main Damping Rings. One contribution to this accomplishment has been the use of Beam Based Alignment (BBA) techniques. The mode of operation of the ATF presents particular challenges for BBA, and we describe here how we have deduced the offsets of the BPMs with respect to the quadrupoles. We also discuss a technique that allows for direct measurements of the beam-to-quad offsets

The CDK inhibitor p21 is a novel target gene of ATF4 and contributes to cell survival under ER stress.

Science.gov (United States)

Inoue, Yasumichi; Kawachi, Shiori; Ohkubo, Tsubasa; Nagasaka, Mai; Ito, Shogo; Fukuura, Keishi; Itoh, Yuka; Ohoka, Nobumichi; Morishita, Daisuke; Hayashi, Hidetoshi

2017-11-01

Activating transcription factor 4 (ATF4) is well known for its role in the endoplasmic reticulum (ER) stress response. ATF4 also transcriptionally induces multiple effectors that determine cell fate depending on cellular context. In addition, ATF4 can communicate both pro-apoptotic and pro-survival signals. How ATF4 mediates its prosurvival roles, however, requires further investigation. Here, we report that the CDK inhibitor p21 is a novel target gene of ATF4. We identified two ATF4-responsive elements, one of which directly binds ATF4, within the first intron of the p21 gene. Importantly, overexpression of p21 enhances cell survival following ER stress induction, while p21 knockdown increases cell death. These results suggest that p21 induction plays a vital role in the cellular response to ER stress and indicate that p21 is a prosurvival effector of ATF4. © 2017 Federation of European Biochemical Societies.

Functional analysis of atfA gene to stress response in pathogenic thermal dimorphic fungus Penicillium marneffei.

Directory of Open Access Journals (Sweden)

Panjaphorn Nimmanee

Full Text Available Penicillium marneffei, the pathogenic thermal dimorphic fungus is a causative agent of a fatal systemic disease, penicilliosis marneffei, in immunocompromised patients especially HIV patients. For growth and survival, this fungus has to adapt to environmental stresses outside and inside host cells and this adaptation requires stress signaling pathways and regulation of gene expression under various kinds of stresses. In this report, P. marneffei activating transcription factor (atfA gene encoding bZip-type transcription factor was characterized. To determine functions of this gene, atfA isogenic mutant strain was constructed using the modified split marker recombination method. The phenotypes and susceptibility to varieties of stresses including osmotic, oxidative, heat, UV, cell wall and cell membrane stresses of the mutant strain were compared with the wild type and the atfA complemented strains. Results demonstrated that the mRNA expression level of P. marneffei atfA gene increased under heat stress at 42°C. The atfA mutant was more sensitive to sodium dodecyl sulphate, amphotericin B and tert-butyl hydroperoxide than the wild type and complemented strains but not hydrogen peroxide, menadione, NaCl, sorbitol, calcofluor white, itraconazole, UV stresses and heat stress at 39°C. In addition, recovery of atfA mutant conidia after mouse and human macrophage infections was significantly decreased compared to those of wild type and complemented strains. These results indicated that the atfA gene was required by P. marneffei under specific stress conditions and might be necessary for fighting against host immune cells during the initiation of infection.

Fabrication of full-size mock-up for 10° section of ITER vacuum vessel thermal shield

Energy Technology Data Exchange (ETDEWEB)

Kang, Dong Kwon [ITER Korea, National Fusion Research Institute, Daejeon 305-333 (Korea, Republic of); Nam, Kwanwoo, E-mail: kwnam@nfri.re.kr [ITER Korea, National Fusion Research Institute, Daejeon 305-333 (Korea, Republic of); Kang, Kyoung-O; Noh, Chang Hyun; Chung, Wooho [ITER Korea, National Fusion Research Institute, Daejeon 305-333 (Korea, Republic of); Lim, Kisuk; Kang, Youngkil [SFA Engineering Corp., Asan-si, Chungcheongnam-do 336-873 (Korea, Republic of); Hamlyn-Harris, Craig; Her, Namil; Robby, Hicks [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St. Paul Lez Durance Cedex (France)

2015-10-15

In this paper, a full-scale prototype fabrication for vacuum vessel thermal shield (VVTS) of ITER tokamak is described and test results are reported. All the manufacturing processes except for silver coating were performed in the fabrication of 10° section of VVTS. Pre-qualification test was conducted to compare the vertical and the horizontal welding positions. After shell welding, shell distortion was measured and adjusted. Shell thickness change was also measured after buffing process. Specially, VVTS ports need large bending and complex welding of shell and flange. Bending method for the complex and long cooling tube layout especially for the VVTS ports was developed in detail. Dimensional inspection of the fabricated mock-up was performed with a 3D laser scanner and the scanning data was analyzed.

PcToll2 positively regulates the expression of antimicrobial peptides by promoting PcATF4 translocation into the nucleus.

Science.gov (United States)

Lan, Jiang-Feng; Zhao, Li-Juan; Wei, Shun; Wang, Yuan; Lin, Li; Li, Xin-Cang

2016-11-01

Drosophila Toll and mammalian Toll-like receptors (TLRs) are a family of evolutionarily conserved immune receptors that play a crucial role in the first-line defense against intruded pathogens. Activating transcription factor 4 (ATF4), a member of the ATF/CREB transcription factor family, is an important factor that participates in TLR signaling and other physiological processes. However, in crustaceans, whether ATF4 homologs were involved in TLR signaling remains unclear. In the current study, we identified a Toll homolog PcToll2 and a novel ATF4 homolog PcATF4 from Procambarus clarkii, and analyzed the likely regulatory activity of PcATF4 in PcToll2 signaling. The complete cDNA sequence of PcToll2 was 4175 bp long containing an open reading frame of 2820 bp encoding a 939-amino acid protein, and the cDNA sequence of PcATF4 was 2027 bp long with an open reading frame of 1296 bp encoding a 431-amino acid protein. PcToll2 and human TLR4 shared the high identity and they were grouped into a cluster. Furthermore, PcToll2 had a close relationship with other shrimp TLRs that possessed potential antibacterial activity. PcToll2 was highly expressed in the hemocytes, heart and gills, while PcATF4 mainly distributed in gills. Upon challenge with Vibrio parahemolyticus, PcToll2 and PcATF4 together with the antimicrobial peptides of ALF1 and ALF2 were significantly up-regulated in the hemocytes, and the PcATF4 was translocated into the nucleus. After PcToll2 silencing and challenge with Vibrio, the translocation of PcATF4 into the nucleus was inhibited and the expression of ALF1 and ALF2 was reduced, but the expression of PcDorsal and PcSTAT was not affected. Furthermore, after PcATF4 knockdown and challenge with or without Vibrio, the expression of ALF1 and ALF2 was also decreased while the expression of PcToll2 was upregulated. These results suggested that PcToll2 might regulate the expression of ALF1 and ALF2 by promoting the import of PcATF4, instead of the routine

Vacuum exhaust duct used for thermonuclear device

International Nuclear Information System (INIS)

Tachikawa, Nobuo; Kondo, Mitsuaki; Honda, Tsutomu.

1990-01-01

The present invention concerns a vacuum exhaust duct used for a thermonuclear device. A cylindrical metal liners is lined with a gap to the inside of a vacuum exhaust duct main body. Bellows are connected to both ends of the metal liners and the end of the bellows is welded to the vacuum exhaust duct main body. Futher, a heater is mounted to the metal liner on the side of the vacuum exhaust duct main body, and the metal liner is heated by the heater to conduct baking for the vacuum exhaust duct main body. Accordingly, since there is no requirement for elevating the temperature of the vacuum exhaust duct upon conducting baking, the vacuum exhaust duct scarcely suffers substantial deformation due to heat expansion. Further, there is also no substantial deformation for the bellows disposed between the outer circumference of the vacuum vessel and a portion of a vacuum exhaust duct, so that the durability of the bellows is greatly improved. (I.S.)

High-brightness electron beam diagnostics at the ATF

International Nuclear Information System (INIS)

Wang, X.J.; Ben-Zvi, I.

1996-01-01

The Brookhaven Accelerator Test Facility (ATF) is a dedicated user facility for accelerator physicists. Its design is optimized to explore laser acceleration and coherent radiation production. To characterize the low-emittance, picoseconds long electron beam produced by the ATF's photocathode RF gun, we have installed electron beam profile monitors for transverse emittance measurement, and developed a new technique to measure electron beam pulse length by chirping the electron beam energy. We have also developed a new technique to measure the ps slice emittance of a 10 ps long electron beam. Stripline beam position monitors were installed along the beam to monitor the electron beam position and intensity. A stripline beam position monitor was also used to monitor the timing jitter between the RF system and laser pulses. Transition radiation was used to measure electron beam energy, beam profile and electron beam bunch length

Reconstruction of vacuum magnetic flux in QUEST

International Nuclear Information System (INIS)

Ishiguro, Masaki; Hanada, Kazuaki; Nakamura, Kazuo

2010-01-01

It is important to determine the best method for reconstructing the magnetic flux when eddy currents are significantly induced during magnetic measurement in spherical tokamaks (STs). Four methods for this reconstruction are investigated, and the calculated magnetic fluxes are compared to those measured in the cavity of a vacuum vessel. The results show that the best method is the one that uses currents from virtual coils for reconstruction. In this method, the placement of the virtual coils is optimized with numerical simulations using the Akaike information criterion (AIC), which indicates the goodness of fit of models used to fit measured data. The virtual coils are set on a line 15 cm outside the vacuum vessel. (author)

Design of the MFTF external vacuum system

International Nuclear Information System (INIS)

Holl, P.M.

1979-01-01

As a result of major experiment success in the LLL mirror program on start-up and stabilization of plasmas in minimum-B magnetic geometry, a Mirror Fusion Test Facility (MFTF) is under construction. Completion is scheduled for September, 1981. MFTF will be used to bridge the gap between present day small mirror experiments and future fusion-reactor activity based on magnetic mirrors. The focal point of the Mirror Fusion Test Facility is the 35 foot diameter by 60 foot long vacuum vessel which encloses the superconducting magnets. High vacuum conditions in the vessel are required to establish and maintain a plasma, and to create and deliver energetic neutral atoms to heat the plasma at the central region

Vacuum Bellows, Vacuum Piping, Cryogenic Break, and Copper Joint Failure Rate Estimates for ITER Design Use

Energy Technology Data Exchange (ETDEWEB)

L. C. Cadwallader

2010-06-01

The ITER international project design teams are working to produce an engineering design in preparation for construction of the International Thermonuclear Experimental Reactor (ITER) tokamak. During the course of this work, questions have arisen in regard to safety barriers and equipment reliability as important facets of system design. The vacuum system designers have asked several questions about the reliability of vacuum bellows and vacuum piping. The vessel design team has asked about the reliability of electrical breaks and copper-copper joints used in cryogenic piping. Research into operating experiences of similar equipment has been performed to determine representative failure rates for these components. The following chapters give the research results and the findings for vacuum system bellows, power plant stainless steel piping (amended to represent vacuum system piping), cryogenic system electrical insulating breaks, and copper joints.

EAST-AIA deployment under vacuum: Calibration of laser diagnostic system using computer vision

Energy Technology Data Exchange (ETDEWEB)

Yang, Yang, E-mail: yangyang@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Sciences, 350 Shushanhu Rd, Hefei, Anhui (China); Song, Yuntao; Cheng, Yong; Feng, Hansheng; Wu, Zhenwei; Li, Yingying; Sun, Yongjun; Zheng, Lei [Institute of Plasma Physics, Chinese Academy of Sciences, 350 Shushanhu Rd, Hefei, Anhui (China); Bruno, Vincent; Eric, Villedieu [CEA-IRFM, F-13108 Saint-Paul-Lez-Durance (France)

2016-11-15

Highlights: • The first deployment of the EAST articulated inspection arm robot under vacuum is presented. • A computer vision based approach to measure the laser spot displacement is proposed. • An experiment on the real EAST tokamak is performed to validate the proposed measure approach, and the results shows that the measurement accuracy satisfies the requirement. - Abstract: For the operation of EAST tokamak, it is crucial to ensure that all the diagnostic systems are in the good condition in order to reflect the plasma status properly. However, most of the diagnostic systems are mounted inside the tokamak vacuum vessel, which makes them extremely difficult to maintain under high vacuum condition during the tokamak operation. Thanks to a system called EAST articulated inspection arm robot (EAST-AIA), the examination of these in-vessel diagnostic systems can be performed by an embedded camera carried by the robot. In this paper, a computer vision algorithm has been developed to calibrate a laser diagnostic system with the help of a monocular camera at the robot end. In order to estimate the displacement of the laser diagnostic system with respect to the vacuum vessel, several visual markers were attached to the inner wall. This experiment was conducted both on the EAST vacuum vessel mock-up and the real EAST tokamak under vacuum condition. As a result, the accuracy of the displacement measurement was within 3 mm under the current camera resolution, which satisfied the laser diagnostic system calibration.

The transcription factor ATF3 is upregulated during chondrocyte differentiation and represses cyclin D1 and A gene transcription

Directory of Open Access Journals (Sweden)

James Claudine G

2006-09-01

Full Text Available Abstract Background Coordinated chondrocyte proliferation and differentiation are required for normal endochondral bone growth. Transcription factors binding to the cyclicAMP response element (CRE are known to regulate these processes. One member of this family, Activating Tanscription Factor 3 (ATF3, is expressed during skeletogenesis and acts as a transcriptional repressor, but the function of this protein in chondrogenesis is unknown. Results Here we demonstrate that Atf3 mRNA levels increase during mouse chondrocyte differentiation in vitro and in vivo. In addition, Atf3 mRNA levels are increased in response to cytochalasin D treatment, an inducer of chondrocyte maturation. This is accompanied by increased Atf3 promoter activity in cytochalasin D-treated chondrocytes. We had shown earlier that transcription of the cell cycle genes cyclin D1 and cyclin A in chondrocytes is dependent on CREs. Here we demonstrate that overexpression of ATF3 in primary mouse chondrocytes results in reduced transcription of both genes, as well as decreased activity of a CRE reporter plasmid. Repression of cyclin A transcription by ATF3 required the CRE in the cyclin A promoter. In parallel, ATF3 overexpression reduces the activity of a SOX9-dependent promoter and increases the activity of a RUNX2-dependent promoter. Conclusion Our data suggest that transcriptional induction of the Atf3 gene in maturing chondrocytes results in down-regulation of cyclin D1 and cyclin A expression as well as activation of RUNX2-dependent transcription. Therefore, ATF3 induction appears to facilitate cell cycle exit and terminal differentiation of chondrocytes.

In-vessel remote maintenance of the Compact Ignition Tokamak

International Nuclear Information System (INIS)

Tabor, M.A.; Hager, E.R.; Creedon, R.L.; Fisher, M.V.; Atkin, S.D.

1987-01-01

The Compact Ignition Tokamak (CIT) is the first deuterium-tritium (D-T) fusion device that will study the physics of an ignited plasma. The ability of the tokamak vacuum vessel to be maintained remotely while under vacuum has not been fully demonstrated on previous machines, and this ability will be critical to the efficient and safe operation of ignition devices. Although manned entry into the CIT vacuum vessel will be possible during the nonactivated stages of operation, remotely automated equipment will be used to assist in initial assembly of the vessel as well as to maintain all in-vessel components once the D-T burn is achieved. Remote maintenance and operation will be routinely required for replacement of thermal protection tiles, inspection of components, leak detection, and repair welding activities. Conceptual design to support these remote maintenance activities has been integrated with the conceptual design of the in-vessel components to provide a complete and practical remote maintenance system for CIT. The primary remote assembly and maintenance operations on CIT will be accomplished through two dedicated 37- x 100-cm ports on the main toroidal vessel. Each port contains a single articulated boom manipulator (ABM), which is capable of accessing half of the torus. The proposed ABM consists of a movable carriage assembly, telescoping two-part mast, and articulated link sections. 1 ref

Overall behaviour of PFC integrated SST-1 vacuum system

Science.gov (United States)

Khan, Ziauddin; Raval, Dilip C.; Paravasu, Yuvakiran; Semwal, Pratibha; Dhanani, Kalpeshkumar R.; George, Siju; Shoaib, Mohammad; Prakash, Arun; Babu, Gattu R.; Thankey, Prashant; Pathan, Firozkhan S.; Pradhan, Subrata

2017-04-01

As a part of phase-I up-gradation of Steady-state Superconducting Tokamak (SST-1), Graphite Plasma Facing Components (PFCs) have been integrated inside SST-1 vacuum vessel as a first wall (FW) during Nov 14 and May 2015. The SST-1 FW has a total surface area of the installed PFCs exposed to plasma is ∼ 40 m2 which is nearly 50% of the total surface area of stainless steel vacuum chamber (∼75 m2). The volume of the vessel within the PFCs is ∼ 16 m3. After the integration of PFCs, the entire vessel as well as the PFC cooling/baking circuits has been qualified with an integrated helium leak tightness of baked at 250 °C for nearly 20 hours employing hot nitrogen gas to remove the absorbed water vapours. Thereafter, Helium glow discharges cleaning were carried out towards the removal of surface impurities. The pump down characteristics of SST-1 vacuum chamber and the changes in the residual gaseous impurities after the installation of the PFCs will be discussed in this paper.

Visual tritium imaging of In-Vessel surfaces

International Nuclear Information System (INIS)

Gentile, C. A.; Zweben, S. J.; Skinner, C. H.; Young, K. M.; Langish, S. W.; Nishi, M. F.; Shu, W. M.; Parker, J.; Isobe, K.

2000-01-01

A imaging detector has been developed for the purpose of providing a non-destructive, real time method of determining tritium concentrations on the surface of internal TFTR vacuum vessel components. The detector employs a green phosphor screen (P31, zinc sulfide: copper) with a wave length peak of 530 nm, a charge-coupled device (CCD) camera linked to a computer, and a detection chamber for inserting components recovered from the vacuum vessel. This detector is capable of determining tritium concentrations on the surfaces. The detector provides a method of imaging tritium deposition on the surfaces in a fairly rapid fashion

Visual tritium imaging of in-vessel surfaces

International Nuclear Information System (INIS)

Gentile, C.A.; Zweben, S.J.; Skinner, C.H.; Young, K.M.; Langish, S.W.; Nishi, M.F.; Shu, W.M.; Parker, J.; Isobe, K.

2000-01-01

An imaging detector has been developed for the purpose of providing a non-destructive, real time method of determining tritium concentrations on the surface of internal TFTR vacuum vessel components. The detector employs a green phosphor screen (P31, zinc sulfide: copper) with a wave length peak of 530 nm, a charge-coupled device (CCD) camera linked to a computer, and a detection chamber for inserting components recovered from the vacuum vessel. This detector is capable of determining tritium concentrations on the surfaces. The detector provides a method of imaging tritium deposition on the surfaces in a fairly rapid fashion

Transcriptome-Based Modeling Reveals that Oxidative Stress Induces Modulation of the AtfA-Dependent Signaling Networks in Aspergillus nidulans

Directory of Open Access Journals (Sweden)

Erzsébet Orosz

2017-01-01

Full Text Available To better understand the molecular functions of the master stress-response regulator AtfA in Aspergillus nidulans, transcriptomic analyses of the atfA null mutant and the appropriate control strains exposed to menadione sodium bisulfite- (MSB-, t-butylhydroperoxide- and diamide-induced oxidative stresses were performed. Several elements of oxidative stress response were differentially expressed. Many of them, including the downregulation of the mitotic cell cycle, as the MSB stress-specific upregulation of FeS cluster assembly and the MSB stress-specific downregulation of nitrate reduction, tricarboxylic acid cycle, and ER to Golgi vesicle-mediated transport, showed AtfA dependence. To elucidate the potential global regulatory role of AtfA governing expression of a high number of genes with very versatile biological functions, we devised a model based on the comprehensive transcriptomic data. Our model suggests that an important function of AtfA is to modulate the transduction of stress signals. Although it may regulate directly only a limited number of genes, these include elements of the signaling network, for example, members of the two-component signal transduction systems. AtfA acts in a stress-specific manner, which may increase further the number and diversity of AtfA-dependent genes. Our model sheds light on the versatility of the physiological functions of AtfA and its orthologs in fungi.

A first glance at the initial ATF experimental results

International Nuclear Information System (INIS)

Carreras, B.A.; Dominguez, N.; Leboeuf, J.N.; Lynch, V.E.; Charlton, L.A.

1989-05-01

In the initial phase of ATF operation, the plasma minor radius and the edge rotational transform were reduced by field errors. This caused an effective change of the magnetic configuration: it improved the stability properties but worsened the equilibrium properties. The threshold for the second stability regime was lowered to β 0 /approximately/ 1.5%. Experimental profile data are compatible with operation in the second stability regime, and the achieved beta values, β 0 /approximately/ 3%, are well beyond the theoretically calculated threshold. Magnetic fluctuation measurements showed the effects of beta self-stabilization. They are in reasonable agreement with the predictions of the theory and support the evidence that ATF has already operated in the second stability regime. 24 refs., 20 figs., 1 tab

Advanced light source vacuum policy and vacuum guidelines for beamlines and experiment endstations

International Nuclear Information System (INIS)

Hussain, Z.

1995-08-01

The purpose of this document is to: (1) Explain the ALS vacuum policy and specifications for beamlines and experiment endstations. (2) Provide guidelines related to ALS vacuum policy to assist in designing beamlines which are in accordance with ALS vacuum policy. This document supersedes LSBL-116. The Advanced Light Source is a third generation synchrotron radiation source whose beam lifetime depends on the quality of the vacuum in the storage ring and the connecting beamlines. The storage ring and most of the beamlines share a common vacuum and are operated under ultra-high-vacuum (UHV) conditions. All endstations and beamline equipment must be operated so as to avoid contamination of beamline components, and must include proper safeguards to protect the storage ring vacuum from an accidental break in the beamline or endstation vacuum systems. The primary gas load during operation is due to thermal desorption and electron/photon induced desorption of contaminants from the interior of the vacuum vessel and its components. The desorption rates are considerably higher for hydrocarbon contamination, thus considerable emphasis is placed on eliminating these sources of contaminants. All vacuum components in a beamline and endstation must meet the ALS vacuum specifications. The vacuum design of both beamlines and endstations must be approved by the ALS Beamline Review Committee (BRC) before vacuum connections to the storage ring are made. The vacuum design is first checked during the Beamline Design Review (BDR) held before construction of the beamline equipment begins. Any deviation from the ALS vacuum specifications must be approved by the BRC prior to installation of the equipment on the ALS floor. Any modification that is incorporated into a vacuum assembly without the written approval of the BRC is done at the user's risk and may lead to rejection of the whole assembly

Structural damages prevention of the ITER vacuum vessel and ports by elasto-plastic analysis with regards to RCC-MR

Energy Technology Data Exchange (ETDEWEB)

Martinez, Jean-Marc, E-mail: jean-marc.martinez@iter.org [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St. Paul Lez Durance Cedex (France); Jun, Chang Hoon; Portafaix, Christophe; Alekseev, Alexander; Sborchia, Carlo; Choi, Chang-Ho [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St. Paul Lez Durance Cedex (France); Albin, Vincent [SOM Calcul – Groupe ORTEC, 121 ancien Chemin de Cassis – Immeuble Grand Pré, 13009 Marseille (France); Borrelly, Stephane [Sogeti High Tech, RE2, 180 rue René Descartes, Le Millenium – Bat C, 13857 Aix en Provence (France); Cambazar, Magali [Assystem EOS, 117 rue Jacquard, 84120 Pertuis (France); Gaucher, Thomas [SOM Calcul – Groupe ORTEC, 121 ancien Chemin de Cassis – Immeuble Grand Pré, 13009 Marseille (France); Sfarni, Samir; Tailhardat, Olivier [Assystem EOS, 117 rue Jacquard, 84120 Pertuis (France)

2015-10-15

Highlights: • ITER vacuum vessel (VV) is a part of the first barrier to confine the plasma. • ITER VV as NPE necessitates a third party organization authorized by the French nuclear regulator to assure design, fabrication, and conformance testing and quality assurance, i.e. ANB. • Several types of damages have to be prevented in order to guarantee the structural integrity with regards to RCC-MR. • It is usual to employ non-linear analysis when the “classical” elastic analysis reaches its limit of linear application. • Several structural analyses were performed with many different global and local models of the whole ITER VV. - Abstract: Several types of damages have to be prevented in order to guarantee the structural integrity of a structure with regards to RCC-MR; the P-type damages which can result from the application to a structure of a steadily and regularly increasing loading or a constant loading and the S-type damages during operational loading conditions which can only result from repeated application of loadings associated to the progressive deformations and fatigue. Following RCC-MR, the S-type damages prevention has to be started only when the structural integrity is guaranteed against P-type damages. The verification of the last one on the ITER vacuum vessel and ports has been performed by limit analysis with elasto-(perfectly)plastic material behavior. It is usual to employ non-linear analysis when the “classical” elastic analysis reaches its limit of linear application. Some elasto-plastic analyses have been performed considering several cyclic loadings to evaluate also more realistic structural margins of the against S-type damages.

An FPGA-based Bunch-by-Bunch Position and Angle Feedback System at ATF2

CERN Document Server

Christian, G B; Bett, D R; Burrows, P N; Constance, B; Davis, M R; Gerbershagen, A; Perry, C; Resta Lopez, J

2011-01-01

The FONT5 intra-train feedback system serves as a prototype for an interaction point beam-based feedback system for future electron-positron colliders, such as the International Linear Collider. The system has been tested on the KEK Accelerator Test Facility (ATF) and is deployed to stabilise the beam orbit at the ATF2. The goal of this system is to correct both position and angle jitter in the vertical plane, providing stability of ~1 micron at the entrance to the ATF2 final-focus system. The system comprises three stripline beam position monitors (BPMs) and two stripline kickers, custom low-latency analogue front-end BPM processors, a custom FPGA-based digital processing board with fast ADCs, and custom kicker-drive amplifiers. An overview of the hardware, and the latest results from beam tests at ATF2, will be presented. The total latency of the system with coupled position and angle feedback loops operating simultaneously was measured to be approximately 140 ns. The greatest degree of correction observed ...

Thermofluid experiments for Fusion Reactor Safety. Visualization of exchange flows through breaches of a vacuum vessel in a fusion reactor under the LOVA condition

International Nuclear Information System (INIS)

Fujii, Sadao; Shibazaki, Hiroaki; Takase, Kazuyuki; Kunugi, Tomoaki.

1997-01-01

Exchange flow rates through breaches of a vacuum vessel in a fusion reactor under the LOVA (Loss of VAcuum event) conditions were measured quantitatively by using a preliminary LOVA apparatus and exchange flow patterns over the breach were visualized qualitatively by smoke. Velocity distributions in the exchange flows were predicted from the observed flow patterns by using the correlation method in the flow visualization procedures. Mean velocities calculated from the predicted velocity distributions at the outside of the breach were in good agreement with the LOVA experimental results when the exchange flow velocities were low. It was found that the present flow visualization and the image processing system might be an useful procedure to evaluate the exchange flow rates. (author)

Measurements of flux surfaces in the ATF torsatron

International Nuclear Information System (INIS)

England, A.C.; Colchin, R.J.; Harris, J.H.; Hillis, D.L.; Jernigan, T.C.; Anderson, F.S.B.

1989-01-01

Flux surfaces in the advanced toroidal facility (ATF) torsatron have been measured using electron-beam techniques. The beam was injected toroidally and impinged on a phosphor-coated screen located ∼ 180 degrees from the gun. The gun was mounted on a drive mechanism that enabled the beam to scan the entire cross section of the last closed flux surface in ATF. The screen material was st. steel, coated with ZnO:Zn (P-15 or P-24) phosphor, and the transparency was ∼ 90%. The emitted light was detected with an image-intensified CCD camera that viewed the mesh through a nearby port. The images were displayed directly on a TV monitor and stored on video tape. Frames from the video tape were transferred to a computer, where the image was enhanced and transformed to remove spatial distortions due to the lens and the viewing angle of the camera

Essential role of eIF5-mimic protein in animal development is linked to control of ATF4 expression

Science.gov (United States)

Translational control of ATF4 through upstream ORFs (uORFs) plays an important role in eukaryotic gene regulation. While ATF4 translation is typically induced by inhibitory phosphorylation of eIF2, ATF4 translation can be also induced by expression of a new translational inhibitor protein, eIF5-mimi...

Heat flux to the helium cryogenic system elements in the case of incidental vacuum vessel ventilation with atmospheric air

CERN Multimedia

CERN. Geneva

2016-01-01

The selection process for size in safety equipment for cold vessels or process pipes in cryogenic systems should take into consideration the incidental ventilation of the vacuum vessel with atmospheric air. In this case, a significant heat input toward the cold elements of the system can be expected. A number of experimental investigations have been done for the elements at liquid helium temperature which have been covered with 10 layers of MLI. The typical values of the heat flux were measured in a range of 3.7 to 5.0 kW/m2 of the element surface. The helium temperature parts are typically surrounded by thermal shields that are kept in a temperature range of 50-80K. On the external side, the thermal shields are covered with 30-40 layers of MLI while on the internal side, the shields are bare. The theoretical calculations of heat flux to the thermal shield, with respect to the possibility of air condensation and freezing on the bare side of the thermal shield, show that the heat flux to the thermal shield can...

SAMS: The synchronization and monitoring system for ATF [Advanced Toroidal Facility] data acquisition

International Nuclear Information System (INIS)

Greenwood, D.E.

1987-01-01

SAMS performs much of the synchronization of the distributed data acquisition system for the Advanced Toroidal Facility (ATF). SAMS is responsible for propagating shot information and managing te data system directories and logical names. This paper describes how SAMS communicates with other processes, both within the VAX cluster that supports most of the ATF data acquisition and on VAXes that are connected to the cluster via DECnet. 3 refs

Design features of the KSTAR in-vessel control coils

Energy Technology Data Exchange (ETDEWEB)

Kim, H.K. [National Fusion Research Institute (NFRI), 52 Yeoeun-dong, Yusung-ku, Daejeon, 305-333 (Korea, Republic of)], E-mail: hkkim@nfri.re.kr; Yang, H.L.; Kim, G.H.; Kim, Jin-Yong; Jhang, Hogun; Bak, J.S.; Lee, G.S. [National Fusion Research Institute (NFRI), 52 Yeoeun-dong, Yusung-ku, Daejeon, 305-333 (Korea, Republic of)

2009-06-15

In-vessel control coils (IVCCs) are to be used for the fast plasma position control, field error correction (FEC), and resistive wall mode (RWM) stabilization for the Korea Superconducting Tokamak Advanced Research (KSTAR) device. The IVCC system comprises 16 segments to be unified into a single set to achieve following remarkable engineering advantages; (1) enhancement of the coil system reliability with no welding or brazing works inside the vacuum vessel, (2) simplification in fabrication and installation owing to coils being fabricated outside the vacuum vessel and installed after device assembly, and (3) easy repair and maintenance of the coil system. Each segment is designed in 8 turns coil of 32 mm x 15 mm rectangular oxygen free high conductive copper with a 7 mm diameter internal coolant hole. The conductors are enclosed in 2 mm thick Inconel 625 rectangular welded vacuum jacket with epoxy/glass insulation. Structural analyses were implemented to evaluate structural safety against electromagnetic loads acting on the IVCC for the various operation scenarios using finite element analysis. This paper describes the design features and structural analysis results of the KSTAR in-vessel control coils.

Study of radiation heat transfer between PFC and vacuum vessel during SST-1 baking

Energy Technology Data Exchange (ETDEWEB)

Chaudhuri, Paritosh E-mail: paritosh@ipr.res.in; Chenna Reddy, D.; Santra, P.; Khirwadkar, S.; Ravi Pragash, N.; Saxena, Y.C

2003-01-01

Steady-state superconducting tokamak (SST-1) is a medium size tokamak with superconducting magnetic field coils. Plasma facing components (PFC) of SST-1 are placed inside the vacuum vessel (VV) of the tokamak and are designed to be compatible for steady-state operation. The main consideration in the design of the PFC is the steady-state heat removal of up to 1 MW/m{sup 2}. In addition to remove high heat fluxes, the PFC are also designed to be compatible for baking at high temperature. Since it is difficult to calculate the radiation heat loads between PFC and VV in a 3-D irregular geometry, a simplified model of concentric cylinders has been chosen for the purpose of estimation of the power requirements and the thermal responses of PFC and VV during their bakeout phases. Thermal responses of the PFC and VV have been analysed and the analytical results have been compared with 2-D finite element analysis using ANSYS. The radiation losses between PFC and VV also have been evaluated on the actual model containing all PFC inside the VV.

Modeling and analysis of alternative concept of ITER vacuum vessel primary heat transfer system

International Nuclear Information System (INIS)

Carbajo, Juan; Yoder, Graydon; Dell'Orco, G.; Curd, Warren; Kim, Seokho

2010-01-01

A RELAP5-3D model of the ITER (Latin for 'the way') vacuum vessel (VV) primary heat transfer system has been developed to evaluate a proposed design change that relocates the heat exchangers (HXs) from the exterior of the tokamak building to the interior. This alternative design protects the HXs from external hazards such as wind, tornado, and aircraft crash. The proposed design integrates the VV HXs into a VV pressure suppression system (VVPSS) tank that contains water to condense vapour in case of a leak into the plasma chamber. The proposal is to also use this water as the ultimate sink when removing decay heat from the VV system. The RELAP5-3D model has been run under normal operating and abnormal (decay heat) conditions. Results indicate that this alternative design is feasible, with no effects on the VVPSS tank under normal operation and with tank temperature and pressure increasing under decay heat conditions resulting in a requirement to remove steam generated if the VVPSS tank low pressure must be maintained.

Deciphering the role of the signal- and Sty1 kinase-dependent phosphorylation of the stress-responsive transcription factor Atf1 on gene activation.

Science.gov (United States)

Salat-Canela, Clàudia; Paulo, Esther; Sánchez-Mir, Laura; Carmona, Mercè; Ayté, José; Oliva, Baldo; Hidalgo, Elena

2017-08-18

Adaptation to stress triggers the most dramatic shift in gene expression in fission yeast ( Schizosaccharomyces pombe ), and this response is driven by signaling via the MAPK Sty1. Upon activation, Sty1 accumulates in the nucleus and stimulates expression of hundreds of genes via the nuclear transcription factor Atf1, including expression of atf1 itself. However, the role of stress-induced, Sty1-mediated Atf1 phosphorylation in transcriptional activation is unclear. To this end, we expressed Atf1 phosphorylation mutants from a constitutive promoter to uncouple Atf1 activity from endogenous, stress-activated Atf1 expression. We found that cells expressing a nonphosphorylatable Atf1 variant are sensitive to oxidative stress because of impaired transcription of a subset of stress genes whose expression is also controlled by another transcription factor, Pap1. Furthermore, cells expressing a phospho-mimicking Atf1 mutant display enhanced stress resistance, and although expression of the Pap1-dependent genes still relied on stress induction, another subset of stress-responsive genes was constitutively expressed in these cells. We also observed that, in cells expressing the phospho-mimicking Atf1 mutant, the presence of Sty1 was completely dispensable, with all stress defects of Sty1-deficient cells being suppressed by expression of the Atf1 mutant. We further demonstrated that Sty1-mediated Atf1 phosphorylation does not stimulate binding of Atf1 to DNA but, rather, establishes a platform of interactions with the basal transcriptional machinery to facilitate transcription initiation. In summary, our results provide evidence that Atf1 phosphorylation by the MAPK Sty1 is required for oxidative stress responses in fission yeast cells by promoting transcription initiation. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

Magnetic analysis including the field due to vacuum vessel eddy currents in the Hitachi Tokamak (HT-2)

International Nuclear Information System (INIS)

Abe, Mitsushi; Takeuchi, Kazuhiro; Fukumoto, Hideshi; Otsuka, Michio

1989-01-01

A magnetic analysis to determine plasma surface position is applied to the magnetic data of the Hitachi Tokamak (HT-2). The analysis takes account of toroidal eddy currents on the vacuum vessel wall. Magnetic probes in HT-2 are placed on both sides of the wall (plasma side and outside), making it possible to determine magnitudes of eddy currents which flow in the toroidal direction. The magnitudes of the coil currents and eddy currents are determined so as to reproduce the measured magnetic fields, and to reconstruct flux surfaces and plasma surface are reconstructed. Taking into account the eddy currents, the determination errors of the plasma surface position are reduced by up to 1/2.3 during start-up and terminating phases, compared with the case without eddy currents. (author)

Multi Optical Transition Radiation System for ATF2

International Nuclear Information System (INIS)

Alabau-Gonzalvo, Javier

2012-01-01

In this paper we describe the design, installation and first calibration tests of a Multi Optical Transition Radiation System in the beam diagnostic section of the Extraction (EXT) line of ATF2, close to the multi wire scanner system. This system will be a valuable tool for measuring beam sizes and emittances coming from the ATF Damping Ring. With an optical resolution of about 2 (micro)m an original OTR design (OTR1X) located after the septum at the entrance of the EXT line demonstrated the ability to measure a 5.5 (micro)m beam size in one beam pulse and to take many fast measurements. This gives the OTR the ability to measure the beam emittance with high statistics, giving a low error and a good understanding of emittance jitter. Furthermore the nearby wire scanners will be a definitive test of the OTR as a beam emittance diagnostic device. The multi-OTR system design proposed here is based on the existing OTR1X.

ATF5 polymorphisms influence ATF function and response to treatment in children with childhood acute lymphoblastic leukemia

OpenAIRE

Rousseau, Julie; Gagné, Vincent; Labuda, Malgorzata; Beaubois, Cyrielle; Sinnett, Daniel; Laverdière, Caroline; Moghrabi, Albert; Sallan, Stephen E.; Silverman, Lewis B.; Neuberg, Donna; Kutok, Jeffery L.; Krajinovic, Maja

2011-01-01

Asparaginase is a standard and critical component in the therapy of childhood acute lymphoblastic leukemia. Asparagine synthetase (ASNS) and the basic region leucine zipper activating transcription factor 5 (ATF5) and arginosuccinate synthase 1 (ASS1) have been shown to mediate the antileukemic effect of asparaginase and to display variable expression between leukemia cells that are resistant and sensitive to treatment. Fourteen polymorphisms in the regulatory and coding regions of these gene...

ASME Section VIII Recertification of a 33,000 Gallon Vacuum-jacketed LH2 Storage Vessel for Densified Hydrogen Testing at NASA Kennedy Space Center

Science.gov (United States)

Swanger, Adam M.; Notardonato, William U.; Jumper, Kevin M.

2015-01-01

The Ground Operations Demonstration Unit for Liquid Hydrogen (GODU-LH2) has been developed at NASA Kennedy Space Center in Florida. GODU-LH2 has three main objectives: zero-loss storage and transfer, liquefaction, and densification of liquid hydrogen. A cryogenic refrigerator has been integrated into an existing, previously certified, 33,000 gallon vacuum-jacketed storage vessel built by Minnesota Valley Engineering in 1991 for the Titan program. The dewar has an inner diameter of 9.5 and a length of 71.5; original design temperature and pressure ranges are -423 F to 100 F and 0 to 95 psig respectively. During densification operations the liquid temperature will be decreased below the normal boiling point by the refrigerator, and consequently the pressure inside the inner vessel will be sub-atmospheric. These new operational conditions rendered the original certification invalid, so an effort was undertaken to recertify the tank to the new pressure and temperature requirements (-12.7 to 95 psig and -433 F to 100 F respectively) per ASME Boiler and Pressure Vessel Code, Section VIII, Division 1. This paper will discuss the unique design, analysis and implementation issues encountered during the vessel recertification process.

ATF-1 torsatron studies

International Nuclear Information System (INIS)

Lyon, J.F.; Carreras, B.A.; Charlton, L.A.

1983-01-01

The main advances in the ORNL Stellarator Program since the 1982 IAEA Conference have been: (1) engineering design of the ATF-1 torsatron; (2) extension of 3-D MHD equilibrium and stability studies and calculations of helical axis configurations; (3) study of stable equilibria with greater than or equal to 8% and direct access to the second stability regime; (4) 3-D Monte Carlo and analytic transport calculations which show a large reduction in transport at low collisionality for the absolute value of e phi'/T' greater than or equal to 1; (5) calculation of ambipolar electric fields; and (b) calculation of well confined ion drift surfaces in the ergodic field region outside the last closed flux surface

Signaling dynamics of palmitate-induced ER stress responses mediated by ATF4 in HepG2 cells

Directory of Open Access Journals (Sweden)

Cho Hyunju

2013-01-01

Full Text Available Abstract Background Palmitic acid, the most common saturated free fatty acid, has been implicated in ER (endoplasmic reticulum stress-mediated apoptosis. This lipoapotosis is dependent, in part, on the upregulation of the activating transcription factor-4 (ATF4. To better understand the mechanisms by which palmitate upregulates the expression level of ATF4, we integrated literature information on palmitate-induced ER stress signaling into a discrete dynamic model. The model provides an in silico framework that enables simulations and predictions. The model predictions were confirmed through further experiments in human hepatocellular carcinoma (HepG2 cells and the results were used to update the model and our current understanding of the signaling induced by palmitate. Results The three key things from the in silico simulation and experimental results are: 1 palmitate induces different signaling pathways (PKR (double-stranded RNA-activated protein kinase, PERK (PKR-like ER kinase, PKA (cyclic AMP (cAMP-dependent protein kinase A in a time dependent-manner, 2 both ATF4 and CREB1 (cAMP-responsive element-binding protein 1 interact with the Atf4 promoter to contribute to a prolonged accumulation of ATF4, and 3 CREB1 is involved in ER-stress induced apoptosis upon palmitate treatment, by regulating ATF4 expression and possibly Ca2+ dependent-CaM (calmodulin signaling pathway. Conclusion The in silico model helped to delineate the essential signaling pathways in palmitate-mediated apoptosis.

Alternatives of ITER vacuum vessel support system

International Nuclear Information System (INIS)

Ohmori, Junji; Kitamura, Kazunori; Araki, Masanori; Ohno, Isamu; Shoji, Teruaki

2002-07-01

Optional designs of vacuum vessel (VV) support have been performed for the International Thermonuclear Experimental Reactor (ITER) to reduce stresses and buckling concern of the flexible plate structure in ITER-FDR. One of the optional designs is hanging type VV support concept that consists of top hanging supports at the top of VV and middle radial stoppers in the middle of outboard VV. The hanging supports are located at the toroidal field (TF) coil inboard top region (R∼5400 mm) using the narrow window space surrounded by a poloidal field coil (PF1) and TF coil. The radial stoppers are located inside TF coil cases in the TF coil outboard middle region (R∼9300 mm). The upper flange connection of the radial stoppers should slide in vertical direction to eliminate thermal stress produced by relative thermal displacement between VV wall and TF coil case. Both supports consist of flexible plates and are mounted on 18 locations in toroidal direction. The radial and toroidal reaction forces are shared with the hanging supports and the radial stoppers. However, the vertical force is sustained by only the hanging supports. The others are compressive type support concept that consists of nine VV supports located in alternate divertor port regions in toroidal direction. Two designs have been performed for the VV support concept. One is mounted on TF inter-coil structures (OIS) and the other is on cryostat ring. The compressive support on TF coil OIS is dependent on TF coil movement but that on cryostat is independent. In the optional designs, the bending stress due to the relative thermal displacement between TF coil and VV is classified to primary stress according to ASME Sec. III NF. The stress due to TF coil displacement is also considered as primary stress. The stress due to non-uniform temperature distribution of the flexible plate is classified to secondary stress. The preliminary structural assessments for the optional designs have been performed for all load

RIA simulation tests using driver tube for ATF cladding

Energy Technology Data Exchange (ETDEWEB)

Cinbiz, Mahmut N. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Brown, N. R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Lowden, R. R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Linton, K. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Terrani, K. A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

2017-07-01

Pellet-cladding mechanical interaction (PCMI) is a potential failure mechanism for accident-tolerant fuel (ATF) cladding candidates during a reactivity-initiated accident (RIA). This report summarizes Fiscal Year (FY) 2017 research activities that were undertaken to evaluate the PCMI-like hoop-strain-driven mechanical response of ATF cladding candidates. To achieve various RIA-like conditions, a modified-burst test (MBT) device was developed to produce different mechanical pulses. The calibration of the MBT instrument was accomplished by performing mechanical tests on unirradiated Generation-I iron-chromium-aluminum (FeCrAl) alloy samples. Shakedown tests were also conducted in both FY 2016 and FY 2017 using unirradiated hydrided ZIRLO™ tube samples. This milestone report focuses on testing of ATF materials, but the benchmark tests with hydrided ZIRLO™ tube samples are documented in a recent journal article.a For the calibration and benchmark tests, the hoop strain was monitored using strain gauges attached to the sample surface in the hoop direction. A novel digital image correlation (DIC) system composed of a single high-speed camera and an array of six mirrors was developed for the MBT instrument to better resolve the failure behavior of samples and to provide useful data for validation of high-fidelity modeling and simulation tools. The DIC system enable a 360° view of a sample’s outer surface. This feature was added to the instrument to determine the precise failure location on a sample’s surface for strain predictions. The DIC system was tested on several silicon carbide fiber/silicon carbide matrix (SiC/SiC) composite tube samples at various pressurization rates of the driver tube (which correspond to the strain rates for the samples). The hoop strains for various loading conditions were determined for the SiC/SiC composite tube samples. Future work is planned to enhance understanding of the failure behavior of the ATF cladding candidates of age

Qualification of phased array ultrasonic examination on T-joint weld of austenitic stainless steel for ITER vacuum vessel

Energy Technology Data Exchange (ETDEWEB)

Kim, G.H. [ITER Korea, National Fusion Research Institute, Daejeon 305-333 (Korea, Republic of); Park, C.K., E-mail: love879@hanmail.net [ITER Korea, National Fusion Research Institute, Daejeon 305-333 (Korea, Republic of); Jin, S.W.; Kim, H.S.; Hong, K.H.; Lee, Y.J.; Ahn, H.J.; Chung, W. [ITER Korea, National Fusion Research Institute, Daejeon 305-333 (Korea, Republic of); Jung, Y.H.; Roh, B.R. [Hyundai Heavy Industries Co. Ltd., Ulsan 682-792 (Korea, Republic of); Sa, J.W.; Choi, C.H. [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St. Paul Lez Durance Cedex (France)

2016-11-01

Highlights: • PAUT techniques has been developed by Hyundai Heavy Industries Co., LTD (HHI) and Korea Domestic Agency (KODA) to verify and settle down instrument calibration, test procedures, image processing, and so on. As the first step of development for PAUT technique, Several dozens of qualification blocks with artificial defects, which are parallel side drilled hole, embedded lack of fusion, embedded repair weld notch, and so on, have been designed and fabricated to simulate all potential defects during welding process. Real UT qualification group-1 for T-joint weld was successfully conducted in front of ANB inspector. • In this paper, remarkable progresses of UT qualification are presented for ITER vacuum vessel. - Abstract: Full penetration welding and 100% volumetric examination are required for all welds of pressure retaining parts of the ITER Vacuum Vessel (VV) according to RCC-MR Code and French Order of Nuclear Pressure Equipment (ESPN). The NDE requirement is one of important technical issues because radiographic examination (RT) is not applicable to many welding joints. Therefore the ultrasonic examination (UT) has been selected as an alternative method. Generally the UT on the austenitic welds is regarded as a great challenge due to the high attenuation and dispersion of the ultrasonic signal. In this paper, Phased array ultrasonic examination (PAUT) has been introduced on double sided T-shape austenitic welds of the ITER VV as a major NDE method as well as RT. Several dozens of qualification blocks with artificial defects, which are parallel side drilled hole, embedded lack of fusion, embedded repair weld notch, embedded parallel vertical notch, and so on, have been designed and fabricated to simulate all potential defects during welding process. PAUT techniques on the thick austenitic welds have been developed taking into account the acceptance criteria. Test procedure including calibration of equipment is derived and qualified through

Structural analysis of the JT-60SA cryostat vessel body

Energy Technology Data Exchange (ETDEWEB)

Botija, José, E-mail: jose.botija@ciemat.es [Association EURATOM – CIEMAT, Avda. Complutense 40, 28040 Madrid (Spain); Alonso, Javier; Fernández, Pilar; Medrano, Mercedes; Ramos, Francisco; Rincon, Esther; Soleto, Alfonso [Association EURATOM – CIEMAT, Avda. Complutense 40, 28040 Madrid (Spain); Davis, Sam; Di Pietro, Enrico; Tomarchio, Valerio [Fusion for Energy, JT-60SA European Home Team, 85748 Garching bei Munchen (Germany); Masaki, Kei; Sakasai, Akira; Shibama, Yusuke [JAEA – Japan Atomic Energy Agency, Naka Fusion Institute, Ibaraki 311-0193 (Japan)

2013-10-15

Highlights: ► Structural analysis to validate the JT-60SA cryostat vessel body design. ► Design code ASME 2007 “Boiler and Pressure Vessel Code. Section VIII”. ► First buckling mode: load multiplier of 10.644, higher than the minimum factor 4.7. ► Elastic and elastic–plastic stress analysis meets ASME against plastic collapse. ► Bolted fasteners have been analyzed showing small gaps closed by strong welding. -- Abstract: The JT-60SA cryostat is a stainless steel vacuum vessel (14 m diameter, 16 m height) which encloses the Tokamak providing the vacuum environment (10{sup −3} Pa) necessary to limit the transmission of thermal loads to the components at cryogenic temperature. It must withstand both external atmospheric pressure during normal operation and internal overpressure in case of an accident. The paper summarizes the structural analyses performed in order to validate the JT-60SA cryostat vessel body design. It comprises several analyses: a buckling analysis to demonstrate stability under the external pressure; an elastic and an elastic–plastic stress analysis according to ASME VIII rules, to evaluate resistance to plastic collapse including localized stress concentrations; and, finally, a detailed analysis with bolted fasteners in order to evaluate the behavior of the flanges, assuring the integrity of the vacuum sealing welds of the cryostat vessel body.

Optimized Baking of the DIII-D Vessel

International Nuclear Information System (INIS)

Anderson, P.M.; Kellman, A.G.

1999-01-01

The DIII-D tokamak vacuum vessel baking system is used to heat the vessel walls and internal hardware to an average temperature of 350 C to allow rapid conditioning of the vacuum surfaces. The system combines inductive heating and a circulating hot air system to provide rapid heating with temperature uniformity required by stress considerations. In recent years, the time to reach 350 C had increased from 9 hrs to 14 hrs. To understand and remedy this sluggish heating rate, an evaluation of the baking system was recently performed. The evaluation indicated that the mass of additional in-vessel hardware (50% increase in mass) was primarily responsible. This paper reports on this analysis and the results of the addition of an electric air heater and procedural changes that have been implemented. Preliminary results indicate that the time to 350 C has been decreased to 4.5 hours and the temperature uniformity has improved

ITER-FEAT vacuum vessel and blanket design features and implications for the R&D programme

Science.gov (United States)

Ioki, K.; Dänner, W.; Koizumi, K.; Krylov, V. A.; Cardella, A.; Elio, F.; Onozuka, M.; ITER Joint Central Team; ITER Home Teams

2001-03-01

A configuration in which the vacuum vessel (VV) fits tightly to the plasma aids the passive plasma vertical stability, and ferromagnetic material in the VV reduces the toroidal field ripple. The blanket modules are supported directly by the VV. A full scale VV sector model has provided critical information related to fabrication technology and for testing the magnitude of welding distortions and achievable tolerances. This R&D validated the fundamental feasibility of the double wall VV design. The blanket module configuration consists of a shield body to which a separate first wall is mounted. The separate first wall has a facet geometry consisting of multiple flat panels, where 3-D machining will not be required. A configuration with deep slits minimizes the induced eddy currents and loads. The feasibility and robustness of solid hot isostatic pressing joining were demonstrated in the R&D by manufacturing and testing several small and medium scale mock-ups and finally two prototypes. Remote handling tests and assembly tests of a blanket module have demonstrated the basic feasibility of its installation and removal.

Manufacturing and maintenance technologies developed for a thick-wall structure of the ITER vacuum vessel

International Nuclear Information System (INIS)

Onozuka, M.; Alfile, J.P.; Aubert, Ph.; Dagenais, J.-F.; Grebennikov, D.; Ioki, K.; Jones, L.; Koizumi, K.; Krylov, V.; Maslakowski, J.; Nakahira, M.; Nelson, B.; Punshon, C.; Roy, O.; Schreck, G.

2001-01-01

Development of welding, cutting and non-destructive testing (NDT) techniques, and development of remotized systems have been carried out for on-site manufacturing and maintenance of the thick-wall structure of the International Thermonuclear Experimental Reactor (ITER) vacuum vessel (VV). Conventional techniques, including tungsten inert gas welding, plasma cutting, and ultrasonic inspection, have been improved and optimized for the application to thick austenitic stainless steel plates. In addition, advanced methods have been investigated, including reduced-pressure electron-beam and multi-pass neodymium-doped yttrium aluminum garnet (NdYAG) laser welding, NdYAG laser cutting, and electro-magnetic acoustic transducer inspection, to improve cost and technical performance. Two types of remotized systems with different payloads have been investigated and one of them has been fabricated and demonstrated in field joint welding, cutting, and NDT tests on test mockups and full-scale ITER VV sector models. The progress and results of this development to date provide a high level of confidence that the manufacturing and maintenance of the ITER VV is feasible

Manufacturing and maintenance technologies developed for a thick-wall structure of the ITER vacuum vessel

Energy Technology Data Exchange (ETDEWEB)

Onozuka, M. E-mail: onozukm@itereu.de; Alfile, J.P.; Aubert, Ph.; Dagenais, J.-F.; Grebennikov, D.; Ioki, K.; Jones, L.; Koizumi, K.; Krylov, V.; Maslakowski, J.; Nakahira, M.; Nelson, B.; Punshon, C.; Roy, O.; Schreck, G

2001-09-01

Development of welding, cutting and non-destructive testing (NDT) techniques, and development of remotized systems have been carried out for on-site manufacturing and maintenance of the thick-wall structure of the International Thermonuclear Experimental Reactor (ITER) vacuum vessel (VV). Conventional techniques, including tungsten inert gas welding, plasma cutting, and ultrasonic inspection, have been improved and optimized for the application to thick austenitic stainless steel plates. In addition, advanced methods have been investigated, including reduced-pressure electron-beam and multi-pass neodymium-doped yttrium aluminum garnet (NdYAG) laser welding, NdYAG laser cutting, and electro-magnetic acoustic transducer inspection, to improve cost and technical performance. Two types of remotized systems with different payloads have been investigated and one of them has been fabricated and demonstrated in field joint welding, cutting, and NDT tests on test mockups and full-scale ITER VV sector models. The progress and results of this development to date provide a high level of confidence that the manufacturing and maintenance of the ITER VV is feasible.

TSC [Tokamak Simulation Code] disruption scenarios and CIT [Compact Ignition Tokamak] vacuum vessel force evolution

International Nuclear Information System (INIS)

Sayer, R.O.; Peng, Y.K.M.; Strickler, D.J.; Jardin, S.C.

1990-01-01

The Tokamak Simulation Code and the TWIR postprocessor code have been used to develop credible plasma disruption scenarios for the Compact Ignition Tokamak (CIT) in order to predict the evolution of forces on CIT conducting structures and to provide results required for detailed structural design analysis. The extreme values of net radial and vertical vacuum vessel (VV) forces were found to be F R =-12.0 MN/rad and F Z =-3.0 MN/rad, respectively, for the CIT 2.1-m, 11-MA design. Net VV force evolution was found to be altered significantly by two mechanisms not noted previously. The first, due to poloidal VV currents arising from increased plasma paramagnetism during thermal quench, reduces the magnitude of the extreme F R by 15-50% and modifies the distribution of forces substantially. The second effect is that slower plasma current decay rates give more severe net vertical VV loads because the current decay occurs when the plasma has moved farther from midplane than is the case for faster decay rates. 7 refs., 9 figs., 1 tab

Design of vessel baking system and thermal radiation shields for SST-1

International Nuclear Information System (INIS)

Kumar, E.R.; Nagabhushana, S.; Pathak, H.A.; Panigrahi, S.; Nath, T.R.; Babu, A.V.S; Gangradey, R.; Patel, R.J.; Saxena, Y.C.

1998-01-01

SST-1 is a Steady State Tokamak with a major radius of 1.1 m, minor radius of 0.2 m and toroidal field of 3.0 T. The toroidal and poloidal field coils of SST-1 are superconducting. One of the main objectives of SST-1 is to demonstrate steady state particle removal and active plasma density control which states the necessity of wall conditioning. The vacuum vessel will be baked up to 525 K by passing hot nitrogen gas through the U - channels welded on the inner surface of vacuum vessel. The required mass flow rate at 5 bar is 0.712 Kg/s to maintain 525 K wall temperature in steady state. Superconducting coils operating at 4.5 K will be protected against thermal radiation from hot surfaces using liquid nitrogen cooled panels operating at 87 K. Maximum 1200 litres/hour liquid nitrogen is required during vessel baking. The design of vacuum vessel baking system and thermal radiation shields and related flow analysis are presented here. (authors)

Design of vessel baking system and thermal radiation shields for SST-1

Energy Technology Data Exchange (ETDEWEB)

Kumar, E.R.; Nagabhushana, S.; Pathak, H.A.; Panigrahi, S.; Nath, T.R.; Babu, A.V.S; Gangradey, R.; Patel, R.J.; Saxena, Y.C. [Institute for Plasma Research, Gandhinagar (India)

1998-07-01

SST-1 is a Steady State Tokamak with a major radius of 1.1 m, minor radius of 0.2 m and toroidal field of 3.0 T. The toroidal and poloidal field coils of SST-1 are superconducting. One of the main objectives of SST-1 is to demonstrate steady state particle removal and active plasma density control which states the necessity of wall conditioning. The vacuum vessel will be baked up to 525 K by passing hot nitrogen gas through the U - channels welded on the inner surface of vacuum vessel. The required mass flow rate at 5 bar is 0.712 Kg/s to maintain 525 K wall temperature in steady state. Superconducting coils operating at 4.5 K will be protected against thermal radiation from hot surfaces using liquid nitrogen cooled panels operating at 87 K. Maximum 1200 litres/hour liquid nitrogen is required during vessel baking. The design of vacuum vessel baking system and thermal radiation shields and related flow analysis are presented here. (authors)

A simple in-vessel/FW component viewing system for SST-1

International Nuclear Information System (INIS)

Santra, Prosenjit; Biswas, Prabal; Vasava, Kirit R.; Jaiswal, Snehal; Parekh, Tejas; Chauhan, Pradeep; Patel, Hiteshkumar; Pradhan, Subrata

2015-01-01

A simple compact system is being proposed for in-situ visual inspection of around 3800 First Wall (FW) graphite (armour) tiles in the vacuum vessel of SST-1 tokamak. The 2 DOF, manual driven system (permanently stationed inside vacuum vessel behind outer passive stabilizer) at top and bottom mid-plane locations consist of a rack and pinion mechanism operating a arm with a CCD camera/LED mounted on it, moving over a cam profile to cover approximately 1/8 th of the toroidal span of the vacuum vessel both at interior top/bottom locations with in the FW modules. The camera and LED light should withstand the ultrahigh vacuum conditions, prolonged baking temperatures of around 200°C along with high electromagnetic forces inside the vessel. This system can be operated remotely in-between shots from outside the VV through a linear motion feed through providing linear moment to a rack and pinion mechanism connected to the arm. This mechanism provides a better viewing of the inside FW components and vessel wall surface of tokamak with simple engineering and operational effort. Any information can be acquired from system regarding damages to FWC due to interaction with plasma as well as damage of other support structures inside VV. In comparison to more complicated and complex inspection system used in other tokamaks, this mechanism can be used for frequent in vessel visual inspection, which limits the system to be small, simple, occupying less space and custom made. This system is cheap with a minimum time for realization of the concept. The paper will present the conceptual and engineering design aspect of the in-viewing system, CAD images, its advantages and limitations, camera and LED details, data acquisition and the present status of realization of the project. (author)

Acoustic isolation vessel for measurement of the background noise in microphones

Science.gov (United States)

Ngo, Kim C. T.; Zuckerwar, Allan J.

1993-01-01

An acoustic isolation vessel has been developed to measure the background noise in microphones. The test microphone is installed in an inner vessel, which is suspended within an outer vessel, and the intervening air space is evacuated to a high vacuum. An analytical expression for the transmission coefficient is derived, based on a five-media model, and compared to experiment. At an isolation vacuum of 5 x 10 exp -6 Torr the experimental transmission coefficient was found to be lower than -155 dB at frequencies ranging from 40 to 1200 Hz. Measurements of the A-weighted noise levels of commercial condenser microphones of four different sizes show good agreement with published values.

ATF1 and RAS in exosomes are potential clinical diagnostic markers for cervical cancer.

Science.gov (United States)

Shi, Yanhua; Wang, Wei; Yang, Baozhi; Tian, Hongge

2017-10-01

Cervical cancer is one of the most common cancers among women worldwide. It is highly lethal yet can be treated when found in early stage. Thus, early detection is of significant important for early diagnosis of cervical cancer. Exosomes have been used as biomarkers in clinical diagnosis. It is unknown that whether blood exosomes associated with cervical cancer can be detected and if these exosomes can accurately represent the developmental stage of cervical cancer. Mouse models were made out of a relapsed cervical cancer patient's tumour sample for original and recurrent cervical cancer, and gene analysis in both tumours and exosomes in these mouse models were performed. We found that activating transcription factor 1 (ATF1) and RAS genes were significantly up-regulated in tumours of both primary and recurrent cervical cancer mouse model, and they can also be detected in the blood exosomes of the mouse model. Our results indicated that ATF1 and RAS could be potential candidate biomarkers for cervical cancer in early diagnosis. ATF1 and RAS genes were found significantly elevated in tumours of primary and recurrent cervical cancer mouse model, and they were also detected in the blood exosomes. Therefore, ATF1 and RAS could be used as a diagnostic marker for cervical cancer in the future. Copyright © 2017 John Wiley & Sons, Ltd.

Studies of plasma performance and transport in the advanced toroidal facility (ATF)

International Nuclear Information System (INIS)

Neilson, G.H.; Bigelow, T.S.; Carreras, B.A.

1989-01-01

An overview of recent ATF experimental results and program plans is presented, with emphasis on the role of magnetic configuration controls in transport studies. The ATF operating space is bounded by a density limit that effectively sets a limit on the energy confinement time τ E . Although this limit is not solely due to impurities, it has recently been raised by improved cleanliness following titanium gettering. This has led to collapse-free neutral beam injection (NBI) discharges with global τ E ∼ 16 ms. Preliminary experiments show that stored energy and bootstrap current are sensitive to details of the magnetic configuration. 13 refs., 8 figs

ATF3 mediates inhibitory effects of ethanol on hepatic gluconeogenesis.

Science.gov (United States)

Tsai, Wen-Wei; Matsumura, Shigenobu; Liu, Weiyi; Phillips, Naomi G; Sonntag, Tim; Hao, Ergeng; Lee, Soon; Hai, Tsonwin; Montminy, Marc

2015-03-03

Increases in circulating glucagon during fasting maintain glucose balance by stimulating hepatic gluconeogenesis. Acute ethanol intoxication promotes fasting hypoglycemia through an increase in hepatic NADH, which inhibits hepatic gluconeogenesis by reducing the conversion of lactate to pyruvate. Here we show that acute ethanol exposure also lowers fasting blood glucose concentrations by inhibiting the CREB-mediated activation of the gluconeogenic program in response to glucagon. Ethanol exposure blocked the recruitment of CREB and its coactivator CRTC2 to gluconeogenic promoters by up-regulating ATF3, a transcriptional repressor that also binds to cAMP-responsive elements and thereby down-regulates gluconeogenic genes. Targeted disruption of ATF3 decreased the effects of ethanol in fasted mice and in cultured hepatocytes. These results illustrate how the induction of transcription factors with overlapping specificity can lead to cross-coupling between stress and hormone-sensitive pathways.

Vacuum leak test technique of JT-60

International Nuclear Information System (INIS)

Kaminaga, Atsushi; Arai, Takashi; Kodama, Kozo; Sasaki, Noboru; Saidoh, Masahiro

1998-01-01

Since a vacuum vessel of JT-60 is very large (167 m 3 ) and is combined with many components, such as magnetic coils, neutral beam injection systems and RF heating systems, etc., the position of leak testing exceeds 700. The two kind of techniques for vacuum leak test used in JT-60 has been described. Firstly the probe helium gas can be fed remotely in the three-dimensionally sectioned 54 regions of the JT-60 torus. The leak test was very rapidly performed by using this method. Secondly the helium detector system has been modified by the additional installation of the cryopump, which reduced the background level of the deuterium gas. The sensitivity of vacuum leak test with the cryopump was two orders of magnitude larger than that of without it. The examples of the performed vacuum leak test are stated. The vacuum leaks during experiments were 9 times. They were caused by thermal strain and plasma discharge. The vacuum leaks just after maintenance are 36 times which mainly caused by mis-installation. (author)

Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition

International Nuclear Information System (INIS)

Hackl, Christina; Stoeltzing, Oliver; Lang, Sven A; Moser, Christian; Mori, Akira; Fichtner-Feigl, Stefan; Hellerbrand, Claus; Dietmeier, Wolfgang; Schlitt, Hans J; Geissler, Edward K

2010-01-01

Activating transcription factor-3 (ATF3) is involved in the complex process of cellular stress response. However, its exact role in cancer is discussed controversially because both tumor suppressive and oncogenic effects have been described. Here we followed-up on our previous observation that inhibition of Hsp90 may increase ATF3 expression and sought to determine the role of ATF3 in colon cancer. Regulation of ATF3 was determined in cancer cells using signaling inhibitors and a heat-shock protein-90 (Hsp90) antagonist. Human HCT116 cancer cells were stably transfected with an ATF3-shRNA or a luciferase-shRNA expression plasmid and alterations in cell motility were assessed in migration assays. The impact of ATF3 down-regulation on cancer growth and metastasis were investigated in a subcutaneous tumor model, a model of hepatic tumor growth and in a model of peritoneal carcinomatosis. Human colon cancer tissues were analyzed for ATF3 expression. The results show that therapeutic Hsp90 inhibition substantially up-regulates the expression of ATF3 in various cancer cells, including colon, gastric and pancreatic cancer. This effect was evident both in vitro and in vivo. RNAi mediated knock-down of ATF3 in HCT116 colon cancer cells significantly increased cancer cell migration in vitro. Moreover, in xenogenic mouse models, ATF3 knock-down promoted subcutaneous tumor growth and hepatic metastasis, as well as peritoneal carcinomatosis. Importantly, ATF3 expression was lower in human colon cancer specimens, as compared to corresponding normal surrounding tissues, suggesting that ATF3 may represent a down-regulated tumor suppressor in colon cancer. In conclusion, ATF3 down-regulation in colon cancer promotes tumor growth and metastasis. Considering that blocking Hsp90 induces ATF3 expression, Hsp90 inhibition may represent a valid strategy to treat metastatic colon cancer by up-regulating this anti-metastatic transcription factor

Overview of the ATF [Advanced Toroidal Facility] Program

International Nuclear Information System (INIS)

Lyon, J.F.; Aceto, S.C.; Anderson, F.S.B.

1989-01-01

Initial operation of ATF showed narrow pressure profiles and second stability behavior at lower beta than expected and revealed uncompensated dipoles in the HF winding leads that have since been corrected. Energy confinement times obtained with neutral beam injection and electron cyclotron heating roughly follow the LHD scaling. However, a plasma collapse is observed with NBI 6 refs., 9 figs

Wire alignment system for ATF LINAC

International Nuclear Information System (INIS)

Hayano, H.; Takeda, S.; Matsumoto, H.; Matsui, T.

1994-01-01

A wire based alignment system is adopted to make less than 40μm precision alignment for injector linac of Accelerator Test Facility (ATF). The system consists of two stretched SUS wires, pickup coils and active mover stages. The position of pickup coils in a mount which will be installed into LINAC stages is set to the calculated wire position prior to installation. All of LINAC stages are then moved to keep the calculated position by the active mover. The test results of wire position detection in a long term are described. (author)

Filling the vacuum at LHCb

CERN Multimedia

Katarina Anthony

2013-01-01

Last month, the Vacuum, Surfaces and Coatings (VSC) group was tasked with an unusually delicate operation in the LHCb experiment cavern: removing the LHC beam pipe while keeping the sensitive Vertex Locator vacuum vessel (VELO) completely isolated from the action.   The VSC group seal off the VELO beam pipe with a flange. Image: Gloria Corti. LHCb’s VELO detector is one of the crown jewels of the experiment. With detector elements surrounded by a vacuum, it gets as close as 5 cm from the beam. Fantastic for physics, but difficult for all-important access. “Because of the sensitivity of the VELO detector and its proximity to the beam, the collaboration decided not to bake (see box) its portion of the beam pipe,” says Giulia Lanza (TE-VSC-LBV), the expert in charge of the beam vacuum operation. “Our group was therefore asked to remove the rest of the LHC beam pipe while keeping the VELO portion of the pipe completely isolated. This work...

A proposal of ITER vacuum vessel fabrication specification and results of the full-scale partial mock-up test

International Nuclear Information System (INIS)

Nakahira, M.; Takeda, N.; Kakudate, S.; Onozuka, M.

2008-01-01

The structure and fabrication methods of the ITER vacuum vessel (VV) have been investigated and defined by the ITER International Team (IT). However, some of the current technical specifications are difficult to be achieved from the manufacturing point of view. To solve such an issue, this paper proposes an alternative specification of the VV to the IT's design. A series of the fabrication and assembly procedures for the mock-up are presented, together with candidates of welding configurations. Finally, the paper summarizes the results of mock-up fabrication, such as non-destructive examination of weld lines, obtained welding deformation and issues revealed from the fabrication experience. Based on the results, it is suggested that several issues such as clarification of conditions of repair welding, demonstration of welding distortion control and detectability/localization of internal defects should be solved before manufacturing the ITER VV

Simulation of Diffusive Lithium Evaporation Onto the NSTX Vessel Walls

International Nuclear Information System (INIS)

Stotler, D.P.; Skinner, C.H.; Blanchard, W.R.; Krstic, P.S.; Kugel, H.W.; Schneider, H.; Zakharov, L.E.

2010-01-01

A model for simulating the diffusive evaporation of lithium into a helium filled NSTX vacuum vessel is described and validated against an initial set of deposition experiments. The DEGAS 2 based model consists of a three-dimensional representation of the vacuum vessel, the elastic scattering process, and a kinetic description of the evaporated atoms. Additional assumptions are required to account for deuterium out-gassing during the validation experiments. The model agrees with the data over a range of pressures to within the estimated uncertainties. Suggestions are made for more discriminating experiments that will lead to an improved model.

Safety Analysis in Large Volume Vacuum Systems Like Tokamak: Experiments and Numerical Simulation to Analyze Vacuum Ruptures Consequences

Directory of Open Access Journals (Sweden)

A. Malizia

2014-01-01

Full Text Available The large volume vacuum systems are used in many industrial operations and research laboratories. Accidents in these systems should have a relevant economical and safety impact. A loss of vacuum accident (LOVA due to a failure of the main vacuum vessel can result in a fast pressurization of the vessel and consequent mobilization dispersion of hazardous internal material through the braches. It is clear that the influence of flow fields, consequence of accidents like LOVA, on dust resuspension is a key safety issue. In order to develop this analysis an experimental facility is been developed: STARDUST. This last facility has been used to improve the knowledge about LOVA to replicate a condition more similar to appropriate operative condition like to kamaks. By the experimental data the boundary conditions have been extrapolated to give the proper input for the 2D thermofluid-dynamics numerical simulations, developed by the commercial CFD numerical code. The benchmark of numerical simulation results with the experimental ones has been used to validate and tune the 2D thermofluid-dynamics numerical model that has been developed by the authors to replicate the LOVA conditions inside STARDUST. In present work, the facility, materials, numerical model, and relevant results will be presented.

ATF1 Modulates the Heat Shock Response by Regulating the Stress-Inducible Heat Shock Factor 1 Transcription Complex

Science.gov (United States)

Takii, Ryosuke; Fujimoto, Mitsuaki; Tan, Ke; Takaki, Eiichi; Hayashida, Naoki; Nakato, Ryuichiro; Shirahige, Katsuhiko

2014-01-01

The heat shock response is an evolutionally conserved adaptive response to high temperatures that controls proteostasis capacity and is regulated mainly by an ancient heat shock factor (HSF). However, the regulation of target genes by the stress-inducible HSF1 transcription complex has not yet been examined in detail in mammalian cells. In the present study, we demonstrated that HSF1 interacted with members of the ATF1/CREB family involved in metabolic homeostasis and recruited them on the HSP70 promoter in response to heat shock. The HSF1 transcription complex, including the chromatin-remodeling factor BRG1 and lysine acetyltransferases p300 and CREB-binding protein (CBP), was formed in a manner that was dependent on the phosphorylation of ATF1. ATF1-BRG1 promoted the establishment of an active chromatin state and HSP70 expression during heat shock, whereas ATF1-p300/CBP accelerated the shutdown of HSF1 DNA-binding activity during recovery from acute stress, possibly through the acetylation of HSF1. Furthermore, ATF1 markedly affected the resistance to heat shock. These results revealed the unanticipated complexity of the primitive heat shock response mechanism, which is connected to metabolic adaptation. PMID:25312646

VEGF-A isoforms differentially regulate ATF-2-dependent VCAM-1 gene expression and endothelial-leukocyte interactions.

Science.gov (United States)

Fearnley, Gareth W; Odell, Adam F; Latham, Antony M; Mughal, Nadeem A; Bruns, Alexander F; Burgoyne, Nicholas J; Homer-Vanniasinkam, Shervanthi; Zachary, Ian C; Hollstein, Monica C; Wheatcroft, Stephen B; Ponnambalam, Sreenivasan

2014-08-15

Vascular endothelial growth factor A (VEGF-A) regulates many aspects of vascular physiology. VEGF-A stimulates signal transduction pathways that modulate endothelial outputs such as cell migration, proliferation, tubulogenesis, and cell-cell interactions. Multiple VEGF-A isoforms exist, but the biological significance of this is unclear. Here we analyzed VEGF-A isoform-specific stimulation of VCAM-1 gene expression, which controls endothelial-leukocyte interactions, and show that this is dependent on both ERK1/2 and activating transcription factor-2 (ATF-2). VEGF-A isoforms showed differential ERK1/2 and p38 MAPK phosphorylation kinetics. A key feature of VEGF-A isoform-specific ERK1/2 activation and nuclear translocation was increased phosphorylation of ATF-2 on threonine residue 71 (T71). Using reverse genetics, we showed ATF-2 to be functionally required for VEGF-A-stimulated endothelial VCAM-1 gene expression. ATF-2 knockdown blocked VEGF-A-stimulated VCAM-1 expression and endothelial-leukocyte interactions. ATF-2 was also required for other endothelial cell outputs, such as cell migration and tubulogenesis. In contrast, VCAM-1 was essential only for promoting endothelial-leukocyte interactions. This work presents a new paradigm for understanding how soluble growth factor isoforms program complex cellular outputs and responses by modulating signal transduction pathways. © 2014 Fearnley et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Vacuum system and cleaning techniques in the FTU machines

International Nuclear Information System (INIS)

Alessandrini, C.; Apicella, M.L.; Ferro, C.

1988-01-01

FTU (Frascati Tokamak Upgrade) is a high magnetic field (8T) tokamak under construction at the Frascati Energy Research Center (ENEA). Its vacuum systems has been already manifactured and is presently being assembled. It consist of an all metallic fully welded vessel, pumped by six turbomolecular pumps. The vacuum system has been dimensioned to allow a base pressure lower than 2.6 x 10 -6 Pa. The paper reports the design philosophy of the vacuum system. The results of the cleaning techniques performed on a 1:1 scale toroidal sector of FTU are also presented and discussed

Operational Experiences Tuning the ATF2 Final Focus Optics Towards Obtaining a 37nm Electron Beam IP Spot Size

CERN Document Server

White, Glen; Woodley, Mark; Bai, Sha; Bambade, Philip; Renier, Yves; Bolzon, Benoit; Kamiya, Yoshio; Komamiya, Sachio; Oroku, Masahiro; Yamaguchi, Yohei; Yamanaka, Takashi; Kubo, Kiyoshi; Kuroda, Shigeru; Okugi, Toshiyuki; Tauchi, Toshiaki; Marin, Eduardo

2010-01-01

The primary aim of the ATF2 research accelerator is to test a scaled version of the final focus optics planned for use in next-generation linear lepton colliders. ATF2 consists of a 1.3 GeV linac, damping ring providing lowemittance electron beams (<12pm in the vertical plane), extraction line and final focus optics. The design details of the final focus optics and implementation at ATF2 are presented elsewhere. The ATF2 accelerator is currently being commissioned, with a staged approach to achieving the design IP spot size. It is expected that as we implement more demanding optics and reduce the vertical beta function at the IP, the tuning becomes more difficult and takes longer. We present here a description of the implementation of the tuning procedures and describe operational experiences and performances

Performance Comparison of Different System Identification Algorithms for FACET and ATF2

CERN Document Server

Pfingstner, J; Schulte, D

2013-01-01

Good system knowledge is an essential ingredient for the operation of modern accelerator facilities. For example, beam-based alignment algorithms and orbit feedbacks rely strongly on a precise measurement of the orbit response matrix. The quality of the measurement of this matrix can be improved over time by statistically combining the effects of small system excitations with the help of system identification algorithms. These small excitations can be applied in a parasitic mode without stopping the accelerator operation (on-line). In this work, different system identification algorithms are used in simulation studies for the response matrix measurement at ATF2. The results for ATF2 are finally compared with the results for FACET, latter originating from an earlier work.

An analytical method for calculating stresses and strains of ATF cladding based on thick walled theory

Energy Technology Data Exchange (ETDEWEB)

Kim, Dong Hyun; Kim, Hak Sung [Hanyang University, Seoul (Korea, Republic of); Kim, Hyo Chan; Yang, Yong Sik; In, Wang kee [KAERI, Daejeon (Korea, Republic of)

2016-05-15

In this paper, an analytical method based on thick walled theory has been studied to calculate stress and strain of ATF cladding. In order to prescribe boundary conditions of the analytical method, two algorithms were employed which are called subroutine 'Cladf' and 'Couple' of FRACAS, respectively. To evaluate the developed method, equivalent model using finite element method was established and stress components of the method were compared with those of equivalent FE model. One of promising ATF concepts is the coated cladding, which take advantages such as high melting point, a high neutron economy, and low tritium permeation rate. To evaluate the mechanical behavior and performance of the coated cladding, we need to develop the specified model to simulate the ATF behaviors in the reactor. In particular, the model for simulation of stress and strain for the coated cladding should be developed because the previous model, which is 'FRACAS', is for one body model. The FRACAS module employs the analytical method based on thin walled theory. According to thin-walled theory, radial stress is defined as zero but this assumption is not suitable for ATF cladding because value of the radial stress is not negligible in the case of ATF cladding. Recently, a structural model for multi-layered ceramic cylinders based on thick-walled theory was developed. Also, FE-based numerical simulation such as BISON has been developed to evaluate fuel performance. An analytical method that calculates stress components of ATF cladding was developed in this study. Thick-walled theory was used to derive equations for calculating stress and strain. To solve for these equations, boundary and loading conditions were obtained by subroutine 'Cladf' and 'Couple' and applied to the analytical method. To evaluate the developed method, equivalent FE model was established and its results were compared to those of analytical model. Based on the

A beam-profile monitor for the BNL Accelerator Test Facility (ATF)

International Nuclear Information System (INIS)

Russell, D.P.; McDonald, K.T.

1989-01-01

A beam-profile monitor has been designed to diagnose the 5-MeV high-brightness electron beam from the rf gun of the BNL Accelerator Test Facility (ATF). The monitor consists of a phosphor screen viewed by a CCD camera. The video images are digitized and stored by a framegrabber and analyzed by an IBM PC-AT to extract the emittance. Details of the hardware configuration are presented, along with the spatial resolution of the system measured as a function of phosphor-screen thickness. The strategies which will be used to measure the transverse and longitudinal emittances are briefly mentioned. The system should be capable of measuring a transverse geometric emittance of around 1 mm-mrad, as will be typical of the ATF beam. 6 refs., 2 figs

v-src induction of the TIS10/PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element.

Science.gov (United States)

Xie, W; Fletcher, B S; Andersen, R D; Herschman, H R

1994-10-01

We recently reported the cloning of a mitogen-inducible prostaglandin synthase gene, TIS10/PGS2. In addition to growth factors and tumor promoters, the v-src oncogene induces TIS10/PGS2 expression in 3T3 cells. Deletion analysis, using luciferase reporters, identifies a region between -80 and -40 nucleotides 5' of the TIS10/PGS2 transcription start site that mediates pp60v-src induction in 3T3 cells. This region contains the sequence CGTCACGTG, which includes overlapping ATF/CRE (CGTCA) and E-box (CACGTG) sequences. Gel shift-oligonucleotide competition experiments with nuclear extracts from cells stably transfected with a temperature-sensitive v-src gene demonstrate that the CGTCACGTG sequence can bind proteins at both the ATF/CRE and E-box sequences. Dominant-negative CREB and Myc proteins that bind DNA, but do not transactivate, block v-src induction of a luciferase reporter driven by the first 80 nucleotides of the TIS10/PGS2 promoter. Mutational analysis distinguishes which TIS10/PGS2 cis-acting element mediates pp60v-src induction. E-box mutation has no effect on the fold induction in response to pp60v-src. In contrast, ATF/CRE mutation attenuates the pp60v-src response. Antibody supershift and methylation interference experiments demonstrate that CREB and at least one other ATF transcription factor in these extracts bind to the TIS10/PGS2 ATF/CRE element. Expression of a dominant-negative ras gene also blocks TIS10/PGS2 induction by v-src. Our data suggest that Ras mediates pp60v-src activation of an ATF transcription factor, leading to induced TIS10/PGS2 expression via the ATF/CRE element of the TIS10/PGS2 promoter. This is the first description of v-src activation of gene expression via an ATF/CRE element.

Software design of the hybrid robot machine for ITER vacuum vessel assembly and maintenance

Energy Technology Data Exchange (ETDEWEB)

Li, Ming, E-mail: Ming.Li@lut.fi [Laboratory of Intelligent Machines, Lappeenranta University of Technology (Finland); Wu, Huapeng; Handroos, Heikki [Laboratory of Intelligent Machines, Lappeenranta University of Technology (Finland); Yang, Guangyou [School of Mechanical Engineering, Hubei University of Technology, Wuhan (China)

2013-10-15

A specific software design is elaborated in this paper for the hybrid robot machine used for the ITER vacuum vessel (VV) assembly and maintenance. In order to provide the multi-machining-function as well as the complicated, flexible and customizable GUI designing satisfying the non-standardized VV assembly process in one hand, and in another hand guarantee the stringent machining precision in the real-time motion control of robot machine, a client–server-control software architecture is proposed, which separates the user interaction, data communication and robot control implementation into different software layers. Correspondingly, three particular application protocols upon the TCP/IP are designed to transmit the data, command and status between the client and the server so as to deal with the abundant data streaming in the software. In order not to be affected by the graphic user interface (GUI) modification process in the future experiment in VV assembly working field, the real-time control system is realized as a stand-alone module in the architecture to guarantee the controlling performance of the robot machine. After completing the software development, a milling operation is tested on the robot machine, and the result demonstrates that both the specific GUI operability and the real-time motion control performance could be guaranteed adequately in the software design.

Software design of the hybrid robot machine for ITER vacuum vessel assembly and maintenance

International Nuclear Information System (INIS)

Li, Ming; Wu, Huapeng; Handroos, Heikki; Yang, Guangyou

2013-01-01

A specific software design is elaborated in this paper for the hybrid robot machine used for the ITER vacuum vessel (VV) assembly and maintenance. In order to provide the multi-machining-function as well as the complicated, flexible and customizable GUI designing satisfying the non-standardized VV assembly process in one hand, and in another hand guarantee the stringent machining precision in the real-time motion control of robot machine, a client–server-control software architecture is proposed, which separates the user interaction, data communication and robot control implementation into different software layers. Correspondingly, three particular application protocols upon the TCP/IP are designed to transmit the data, command and status between the client and the server so as to deal with the abundant data streaming in the software. In order not to be affected by the graphic user interface (GUI) modification process in the future experiment in VV assembly working field, the real-time control system is realized as a stand-alone module in the architecture to guarantee the controlling performance of the robot machine. After completing the software development, a milling operation is tested on the robot machine, and the result demonstrates that both the specific GUI operability and the real-time motion control performance could be guaranteed adequately in the software design

The ATF [Advanced Toroidal Facility] Status and Control System

International Nuclear Information System (INIS)

Baylor, L.R.; Devan, W.R.; Sumner, J.N.; Alban, A.M.

1987-01-01

The Advanced Toroidal Facility (ATF) Status and Control System (SCS) is a programmable controller-based state monitoring and supervisory control system. This paper describes the SCS implementation and its use of a host computer to run a commercially available software package that provides color graphic interactive displays, alarm logging, and archiving of state data

ITER-FEAT vacuum vessel and blanket design features and implications for the R and D programme

International Nuclear Information System (INIS)

Ioki, K.; Cardella, A.; Elio, F.; Onozuka, M.; Daenner, W.; Koizumi, K.; Krylov, V.A.

2001-01-01

A configuration in which the vacuum vessel (VV) fits tightly to the plasma aids the passive plasma vertical stability, and ferromagnetic material in the VV reduces the toroidal field ripple. The blanket modules are supported directly by the VV. A full scale VV sector model has provided critical information related to fabrication technology and for testing the magnitude of welding distortions and achievable tolerances. This R and D validated the fundamental feasibility of the double wall VV design. The blanket module configuration consists of a shield body to which a separate first wall is mounted. The separate first wall has a facet geometry consisting of multiple flat panels, where 3-D machining will not be required. A configuration with deep slits minimizes the induced eddy currents and loads. The feasibility and robustness of solid hot isostatic pressing joining were demonstrated in the R and D by manufacturing and testing several small and medium scale mock-ups and finally two prototypes. Remote handling tests and assembly tests of a blanket module have demonstrated the basic feasibility of its installation and removal. (author)

Experimental results of the ATF in-line injection system

International Nuclear Information System (INIS)

Wang, X.J.; Srinivasan-Rao, T.; Batchelor, K.

1995-01-01

The initial experimental results of the Brookhaven accelerator test facility (ATF) in-line injector is presented. The ATF in-line injector employed a full copper RF gun with a pair of solenoid magnets for emittance compensation. The maximum acceleration field of the RF gun was measured to be 130 MV/m. The electron yield from the copper cathode was maximized using p- polarized laser and the Schottky effect. The quantum efficiency under optimum conditions was measured to be 0.04%. The measured electron bunch length was less than 11 ps, which agreed with the laser pulse length measurement using a streak camera. The normalized rms. emittance for 0.25 nC charge is 0.9 ± 0.1 mm-mrad, which is almost four times smaller than the emittance predicted by the space-charge effect for a non-emittance compensation photocathode RF gun. The normalized rms for 0.6 nC charge was measured range from 1 to 3 mm-mrad. This measurement was first experimental demonstration of emittance compensation in a high-gradient, S-band photocathode RF gun

A proposal of ITER vacuum vessel fabrication specification and results of the full-scale partial mock-up test

Energy Technology Data Exchange (ETDEWEB)

Nakahira, M. [Japan Atomic Energy Agency, Mukouyama 801-1, Naka-machi, Naka-gun, Ibaraki 311-0193 (Japan)], E-mail: nakahira.masataka@jaea.go.jp; Takeda, N.; Kakudate, S. [Japan Atomic Energy Agency, Mukouyama 801-1, Naka-machi, Naka-gun, Ibaraki 311-0193 (Japan); Onozuka, M. [Mitsubishi Nuclear Energy Systems, Inc., 1700K Street NW, Suite 440, Washington, DC 20006 (United States)

2008-12-15

The structure and fabrication methods of the ITER vacuum vessel (VV) have been investigated and defined by the ITER International Team (IT). However, some of the current technical specifications are difficult to be achieved from the manufacturing point of view. To solve such an issue, this paper proposes an alternative specification of the VV to the IT's design. A series of the fabrication and assembly procedures for the mock-up are presented, together with candidates of welding configurations. Finally, the paper summarizes the results of mock-up fabrication, such as non-destructive examination of weld lines, obtained welding deformation and issues revealed from the fabrication experience. Based on the results, it is suggested that several issues such as clarification of conditions of repair welding, demonstration of welding distortion control and detectability/localization of internal defects should be solved before manufacturing the ITER VV.

Frontline Science: ATF3 is responsible for the inhibition of TNF-α release and the impaired migration of acute ethanol-exposed monocytes and macrophages.

Science.gov (United States)

Hu, Chaojie; Meng, Xiaoming; Huang, Cheng; Shen, Chenlin; Li, Jun

2017-03-01

Binge drinking represses host innate immunity and leads to a high risk of infection. Acute EtOH-pretreated macrophages exhibit a decreased production of proinflammatory mediators in response to LPS. ATF3 is induced and counter-regulates the LPS/TLR4 inflammatory cascade. Here, we investigated the potential role of ATF3 in LPS tolerance in acute ethanol-pretreated macrophages. We found that there was an inverse correlation between ATF3 and LPS-induced TNF-α production in acute ethanol-pretreated murine monocytes and macrophages. The knockdown of ATF3 attenuated the inhibitory effects of acute ethanol treatment on LPS-induced TNF-α production. Furthermore, ChIP assays and co-IP demonstrated that ATF3, together with HDAC1, negatively modulated the transcription of TNF-α. In binge-drinking mice challenged with LPS, an up-regulation of ATF3 and HDAC1 and a concomitant decrease in TNF-α were observed. Given that HDAC1 was concomitantly induced in acute ethanol-exposed monocytes and macrophages, we used the HDACi TSA or silenced HDAC1 to explore the role of HDAC1 in acute ethanol-treated macrophages. Our results revealed that TSA treatment and HDAC1 knockdown prevented acute ethanol-induced ATF3 expression and the inhibition of TNF-α transcription. These data indicated a dual role for HDAC1 in acute ethanol-induced LPS tolerance. Furthermore, we showed that the induction of ATF3 led to the impaired migration of BM monocytes and macrophages. Overall, we present a novel role for ATF3 in the inhibition of LPS-induced TNF-α and in the impairment of monocyte and macrophage migration. © Society for Leukocyte Biology.

ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma.

Science.gov (United States)

Linares, Juan F; Cordes, Thekla; Duran, Angeles; Reina-Campos, Miguel; Valencia, Tania; Ahn, Christopher S; Castilla, Elias A; Moscat, Jorge; Metallo, Christian M; Diaz-Meco, Maria T

2017-12-05

Tumors undergo nutrient stress and need to reprogram their metabolism to survive. The stroma may play a critical role in this process by providing nutrients to support the epithelial compartment of the tumor. Here we show that p62 deficiency in stromal fibroblasts promotes resistance to glutamine deprivation by the direct control of ATF4 stability through its p62-mediated polyubiquitination. ATF4 upregulation by p62 deficiency in the stroma activates glucose carbon flux through a pyruvate carboxylase-asparagine synthase cascade that results in asparagine generation as a source of nitrogen for stroma and tumor epithelial proliferation. Thus, p62 directly targets nuclear transcription factors to control metabolic reprogramming in the microenvironment and repress tumorigenesis, and identifies ATF4 as a synthetic vulnerability in p62-deficient tumor stroma. Copyright © 2017 Elsevier Inc. All rights reserved.

Analysis of the effect of the Electron-Beam welding sequence for a fixed manufacturing route using finite element simulations applied to ITER vacuum vessel manufacture

Energy Technology Data Exchange (ETDEWEB)

Martín-Menéndez, Cristina, E-mail: cristina@natec-ingenieros.com [Numerical Analysis Technologies, S.L. Marqués de San Esteban No. 52, 33206 Gijón (Spain); Rodríguez, Eduardo [Department of Mechanical Engineering, University of Oviedo, Campus de Gijón, 33203 Gijón (Spain); Ottolini, Marco [Ansaldo Nucleare S.p.A., Corso Perrone 25, 16152 Genova (Italy); Caixas, Joan [F4E, c/Josep Pla, n.2, Torres Diagonal Litoral, Edificio B3, E-08019 Barcelona (Spain); Guirao, Julio [Numerical Analysis Technologies, S.L. Marqués de San Esteban No. 52, 33206 Gijón (Spain)

2016-03-15

Highlights: • The simulation methodology employed in this paper is able to adapt inside a complex manufacturing route. • The effect of the sequence is lower in a highly constrained assembly than in a lowly constrained one. • The most relevant influence on the distortions is the jigs design, instead of the welding sequence. • The welding distortion analysis should be used as a guidance to design and improve the manufacturing strategy. - Abstract: The ITER Vacuum Vessel Sectors have very tight tolerances and high density of welding. Therefore, prediction and reduction of welding distortion are critical to allow the final assembly with the other Vacuum Vessel Sectors without the production of a full scale prototype. In this paper, the effect of the welding sequence in the distortions inside a fixed manufacturing route and in a highly constrained assembly is studied in the poloidal segment named inboard (PS1). This is one of the four poloidal segments (PS) assembled for the sector. Moreover, some restrictions and limitations in the welding sequence related to the manufacturing process are explained. The results obtained show that the effect of the sequence is lower in a highly constrained assembly than in a low constrained one. A prototype manufactured by AMW consortium (PS1 mock-up) is used in order to validate the finite element method welding simulation employed. The obtained results confirmed that for Electron-Beam welds, both the welding simulation and the mock-up show a low value of distortions.

mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4

Directory of Open Access Journals (Sweden)

Yeonwoo Park

2017-05-01

Full Text Available The mammalian target of rapamycin complex 1 (mTORC1 is a master regulator of cell growth that is commonly deregulated in human diseases. Here we find that mTORC1 controls a transcriptional program encoding amino acid transporters and metabolic enzymes through a mechanism also used to regulate protein synthesis. Bioinformatic analysis of mTORC1-responsive mRNAs identified a promoter element recognized by activating transcription factor 4 (ATF4, a key effector of the integrated stress response. ATF4 translation is normally induced by the phosphorylation of eukaryotic initiation factor 2 alpha (eIF2α through a mechanism that requires upstream open reading frames (uORFs in the ATF4 5′ UTR. mTORC1 also controls ATF4 translation through uORFs, but independently of changes in eIF2α phosphorylation. mTORC1 instead employs the 4E-binding protein (4E-BP family of translation repressors. These results link mTORC1-regulated demand for protein synthesis with an ATF4-regulated transcriptional program that controls the supply of amino acids to the translation machinery.

Conceptual design of EAST flexible in-vessel inspection system

International Nuclear Information System (INIS)

Peng, X.B.; Song, Y.T.; Li, C.C.; Lei, M.Z.; Li, G.

2010-01-01

Remote handling technology, especially the flexible in-vessel inspection system (FIVIS) without breaking the working condition of the vacuum vessel, has been identified as one major challenge on the maintenance for the future tokamak fusion reactor. The FIVIS introduced here is specially developed for EAST superconducting tokamak that has actively cooled plasma facing components (PFCs). It aims flexible close-up inspection of EAST PFCs to help the understanding of operation issues that could occur in the vacuum vessel. This paper resumes the preliminary work of the FIVIS project, including the requirement analysis and the development of the conceptual design. The FIVIS consists out of a long reach multi-articulated manipulator and a process tool. The manipulator has a modular design for its subsystems and can reach all areas of the first wall in the distance of 15 mm and in the range of ±90 o along toroidal direction. It will be folded and hidden in the designated horizontal port during plasma discharge period.

Manufacturing progress on the first sector and lower ports for ITER vacuum vessel

Energy Technology Data Exchange (ETDEWEB)

Ahn, H.J., E-mail: hjahn@nfri.re.kr [National Fusion Research Institute, Daejeon 305-333 (Korea, Republic of); Kim, H.S.; Kim, G.H.; Park, C.K.; Hong, G.H.; Jin, S.W.; Lee, H.G.; Jung, K.J. [National Fusion Research Institute, Daejeon 305-333 (Korea, Republic of); Lee, J.S.; Kim, T.S.; Won, J.G.; Roh, B.R.; Park, K.H. [Hyundai Heavy Industries Co. Ltd., Ulsan 682-792 (Korea, Republic of); Sa, J.W.; Choi, C.H.; Sborchia, C. [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul-lez-Durance (France)

2016-11-01

Highlights: • All manufacturing drawings of the first sector of VV have been completed. • Full scale mock-ups have been constructed to verify fabrication procedure. • Qualifications for welding and forming are done and for NDE are ongoing. • Manufacturing progress is around 40% for the sector and LPSE up to the end of 2015. - Abstract: Manufacturing design of Korean sectors and ports for the ITER Vacuum Vessel (VV) has been developed to comply with the tight tolerance and severe inspection requirements. The first VV sector and lower ports are being fabricated slowly under strict regulations after verification using several real scale mock-ups and qualifications for welding, forming and NDE. During three years after start of fabrication, manufacturing progress on four poloidal segments of the first sector is that (1) all inner shells were welded, (2) forgings for complicate components have been machined, (3) port stubs and poloidal T-ribs were assembled, and (4) machined components are welded on the inner shells by narrow-gap TIG welding and electron beam welding. The progress of lower ports is that (1) inner shells of stub extensions were bent and treated with heat, (2) T-ribs were fabricated and examined by qualified phased array UT, (3) supporting pads and gussets have been machined, and (4) inner shells are assembled with T-ribs and machined forgings. The progress rate of manufacturing is around 40% up to the end of 2015 for the first sector and lower port stub extensions.

Design of bunch compressing system with suppression of coherent synchrotron radiation for ATF upgrade

International Nuclear Information System (INIS)

Jing, Yichao; Fedurin, Mikhail; Stratakis, Diktys

2015-01-01

One of the operation modes for Accelerator Test Facility (ATF) upgrade is to provide high peak current, high quality electron beam for users. Such operation requires a bunch compressing system with a very large compression ratio. The CSR originating from the strong compressors generally could greatly degrade the quality of the electron beam. In this paper, we present our design for the entire bunch compressing system that will limit the effect of CSR on the e-beam@s quality. We discuss and detail the performance from the start to end simulation of such a compressor for ATF.

Study of ITER equatorial port plug handling system and vacuum sealing interface

Energy Technology Data Exchange (ETDEWEB)

Martins, Jean-Pierre [Association Euratom CEA, CEA/DSM/IRFM, Cadarache, F-13108 Saint-Paul-lez-Durance (France)], E-mail: jean-pierre.martins@cea.fr; Doceul, Louis; Marol, Sebastien; Delchie, Elise [Association Euratom CEA, CEA/DSM/IRFM, Cadarache, F-13108 Saint-Paul-lez-Durance (France); Cordier, Jean-Jacques; Levesy, Bruno; Tesini, Alessandro [ITER International Organization, F-13108 Saint-Paul-lez-Durance cedex (France); Ciattaglia, Emanuela [EFDA CSU - Garching, Boltzmannstr. 2, D-85748 Garching (Germany); Tivey, Richard [Max-Planck-Institut fuer Plasmaphysik, Boltzmannstr. 2, 85748 Garching (Germany); Gillier, Rene; Abbes, Christophe [GARLOCK - Sealing Technologies - 90, rue de la roche du Geai, F-42029 St-Etienne cedex 1 (France)

2009-06-15

In the field of the ITER port plug engineering and integration task, CEA has contributed to define proposals concerning the port plugs vacuum sealing interface with the vessel flange and the equatorial plug handling. The 2001 baseline vacuum flange sealing consisted of TIG welding of a 316L strip plate on to U shapes. This arrangement presented some issues like welding access, implementation of tools, lip consumption, complex local leak test, continuous leak checking. Therefore, an alternate sealing solution based on the use of metallic gaskets is proposed. The different technical aspects are discussed to explain how this design can simplify the maintenance and deal with safety and vacuum requirements. The design of the mechanical attachment and vacuum sealing of the plug has constantly evolved, but the associated remote handling equipment was not systematically reviewed. An update of the cask and maintenance procedure was studied in order to design it in accordance with the last generic plug flange design. This includes a concept of a gripping system that uses the plug flange bolting area and, to help the remote handling process, a cantilever assisting system is suggested to increase the reliability of the transfer operation between vacuum vessel and cask.

Multistage charged particle accelerator, with high-vacuum insulation

International Nuclear Information System (INIS)

Holl, P.

1976-01-01

A multistage charged-particle accelerator for operating with accelerating voltages higher than 150 kV is described. The device consists essentially of a high-voltage insulator, a source for producing charged particles, a Wehnelt cylinder, an anode, and a post-accelerating tube containing stack-wise positioned post-accelerating electrodes. A high vacuum is used for insulating the parts carrying the high voltages, and at least one cylindrical screen surrounding these parts is interposed between them and the vacuum vessel, which can itself also function as a cylindrical screen

Opportunities for the LWR ATF materials development program to contribute to the LBE-cooled ADS materials qualification program

Energy Technology Data Exchange (ETDEWEB)

Gong, Xing, E-mail: gongxingzfl@hotmail.com [Department of ATF R& D, Nuclear Fuel Research and Development Center, China Nuclear Power Technology Research Institute Co., Ltd., China General Nuclear Power Corporation (CGN), Shenzhen, 518026 (China); Li, Rui, E-mail: li-rui@cgnpc.com.cn [Department of ATF R& D, Nuclear Fuel Research and Development Center, China Nuclear Power Technology Research Institute Co., Ltd., China General Nuclear Power Corporation (CGN), Shenzhen, 518026 (China); Sun, Maozhou; Ren, Qisen [Department of ATF R& D, Nuclear Fuel Research and Development Center, China Nuclear Power Technology Research Institute Co., Ltd., China General Nuclear Power Corporation (CGN), Shenzhen, 518026 (China); Liu, Tong, E-mail: liutong@cgnpc.com.cn [Department of ATF R& D, Nuclear Fuel Research and Development Center, China Nuclear Power Technology Research Institute Co., Ltd., China General Nuclear Power Corporation (CGN), Shenzhen, 518026 (China); Short, Michael P., E-mail: hereiam@mit.edu [Department of Nuclear Science and Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA, 02139 (United States)

2016-12-15

Accelerator-driven systems (ADS) are a promising approach for nuclear waste disposal. Nevertheless, the principal candidate materials proposed for ADS construction, such as the ferritic/martensitic steel, T91, and austenitic stainless steels, 316L and 15-15Ti, are not fully compatible with the liquid lead-bismuth eutectic (LBE) coolant. Under some operating conditions, liquid metal embrittlement (LME) or liquid metal corrosion (LMC) may occur in these steels when exposed to LBE. These environmentally-induced material degradation effects pose a threat to ADS reactor safety, as failure of the materials could initiate a severe accident, in which fission products are released into the coolant. Meanwhile, parallel efforts to develop accident-tolerant fuels (ATF) in light water reactors (LWRs) could provide both general materials design philosophies and specific material solutions to the ADS program. In this paper, the potential contributions of the ATF materials development program to the ADS materials qualification program are evaluated and discussed in terms of service conditions and materials performance requirements. Several specific areas where coordinated development may benefit both programs, including composite materials and selected coatings, are discussed. - Highlights: • ATF materials developed for LWRs could be candidate materials for the LBE-cooled ADS program. • Similar material design and protection philosophies are utilized in both programs. • Unique challenges of LBE-cooled ADS systems could possibly be addressed by LWR ATF materials. • More coordinated testing should be performed between the ATF and ADS programs.

Studies of emittance growth in the ATF

International Nuclear Information System (INIS)

Zimmermann, F.

1997-03-01

Several different mechanisms of emittance growth in the Accelerator Test Facility (ATF) at KEK are investigated: the author calculates rise times of the fast beam-ion instability for the damping ring (DR), and discusses the emittance growth caused by coherent synchrotron radiation in the beam-transport line (BT), the effect of quadrupole wake fields in the injector linac, and, finally, a single-bunch head-tail ion effect that can occur in both the DR and the BT. A first attempt to measure the quadrupole wake on the real machine is also reported

Chatter suppression methods of a robot machine for ITER vacuum vessel assembly and maintenance

International Nuclear Information System (INIS)

Wu, Huapeng; Wang, Yongbo; Li, Ming; Al-Saedi, Mazin; Handroos, Heikki

2014-01-01

Highlights: •A redundant 10-DOF serial-parallel hybrid robot for ITER assembly and maintains is presented. •A dynamic model of the robot is developed. •A feedback and feedforward controller is presented to suppress machining vibration of the robot. -- Abstract: In the process of assembly and maintenance of ITER vacuum vessel (ITER VV), various machining tasks including threading, milling, welding-defects cutting and flexible hose boring are required to be performed from inside of ITER VV by on-site machining tools. Robot machine is a promising option for these tasks, but great chatter (machine vibration) would happen in the machining process. The chatter vibration will deteriorate the robot accuracy and surface quality, and even cause some damages on the end-effector tools and the robot structure itself. This paper introduces two vibration control methods, one is passive and another is active vibration control. For the passive vibration control, a parallel mechanism is presented to increase the stiffness of robot machine; for the active vibration control, a hybrid control method combining feedforward controller and nonlinear feedback controller is introduced for chatter suppression. A dynamic model and its chatter vibration phenomena of a hybrid robot is demonstrated. Simulation results are given based on the proposed hybrid robot machine which is developed for the ITER VV assembly and maintenance

Chatter suppression methods of a robot machine for ITER vacuum vessel assembly and maintenance

Energy Technology Data Exchange (ETDEWEB)

Wu, Huapeng; Wang, Yongbo, E-mail: yongbo.wang@lut.fi; Li, Ming; Al-Saedi, Mazin; Handroos, Heikki

2014-10-15

Highlights: •A redundant 10-DOF serial-parallel hybrid robot for ITER assembly and maintains is presented. •A dynamic model of the robot is developed. •A feedback and feedforward controller is presented to suppress machining vibration of the robot. -- Abstract: In the process of assembly and maintenance of ITER vacuum vessel (ITER VV), various machining tasks including threading, milling, welding-defects cutting and flexible hose boring are required to be performed from inside of ITER VV by on-site machining tools. Robot machine is a promising option for these tasks, but great chatter (machine vibration) would happen in the machining process. The chatter vibration will deteriorate the robot accuracy and surface quality, and even cause some damages on the end-effector tools and the robot structure itself. This paper introduces two vibration control methods, one is passive and another is active vibration control. For the passive vibration control, a parallel mechanism is presented to increase the stiffness of robot machine; for the active vibration control, a hybrid control method combining feedforward controller and nonlinear feedback controller is introduced for chatter suppression. A dynamic model and its chatter vibration phenomena of a hybrid robot is demonstrated. Simulation results are given based on the proposed hybrid robot machine which is developed for the ITER VV assembly and maintenance.

Preliminary electromagnetic, thermal and mechanical design for first wall and vacuum vessel of FAST

Energy Technology Data Exchange (ETDEWEB)

Lucca, F., E-mail: Flavio.Lucca@LTCalcoli.it [LT Calcoli srl, Piazza Prinetti 26/B, 23807 Merate, LC (Italy); Bertolini, C. [LT Calcoli srl, Piazza Prinetti 26/B, 23807 Merate, LC (Italy); Crescenzi, F.; Crisanti, F. [C.R. ENEA Frascati – UT FUS, Via E. Fermi 45, IT-00044 Frascati, RM (Italy); Di Gironimo, G. [CREATE, Università di Napoli Federico II, P.le Tecchio 80, 80125 Napoli (Italy); Labate, C. [CREATE, Università di Napoli Parthenope, Via Acton 38, 80133 Napoli (Italy); Manzoni, M.; Marconi, M.; Pagani, I. [LT Calcoli srl, Piazza Prinetti 26/B, 23807 Merate, LC (Italy); Ramogida, G. [C.R. ENEA Frascati – UT FUS, Via E. Fermi 45, IT-00044 Frascati, RM (Italy); Renno, F. [CREATE, Università di Napoli Federico II, P.le Tecchio 80, 80125 Napoli (Italy); Roccella, M. [LT Calcoli srl, Piazza Prinetti 26/B, 23807 Merate, LC (Italy); Roccella, S. [C.R. ENEA Frascati – UT FUS, Via E. Fermi 45, IT-00044 Frascati, RM (Italy); Viganò, F. [LT Calcoli srl, Piazza Prinetti 26/B, 23807 Merate, LC (Italy)

2015-10-15

The fusion advanced study torus (FAST), with its compact design, high toroidal field and plasma current, faces many of the problems met by ITER, and at the same time anticipates much of the DEMO relevant physics and technology. The conceptual design of the first wall (FW) and the vacuum vessel (VV) has been defined on the basis of FAST operative conditions and of “Snow Flakes” (SF) magnetic topology, which is also relevant for DEMO. The EM loads are one of the most critical load components for the FW and the VV during plasma disruptions and a first dimensioning of these components for such loads is mandatory. During this first phase of R&D activities the conceptual design of the FW and VV have been assessed estimating, by means of FE simulations, the EM loads due to a typical vertical disruption event (VDE) in FAST. EM loads were then transferred on a FE mechanical model of the FAST structures and the mechanical response of the FW and VV design for the analyzed VDE event was assessed. The results indicate that design criteria are not fully satisfied by the current drawing of the VV and FW components. The most critical regions have been individuated and the effect of some geometrical and material changes has been checked in order to improve the structure.

ATF4- and CHOP-Dependent Induction of FGF21 through Endoplasmic Reticulum Stress

Directory of Open Access Journals (Sweden)

Xiao-shan Wan

2014-01-01

Full Text Available Fibroblast growth factor 21 (FGF21 is an important endogenous regulator involved in the regulation of glucose and lipid metabolism. FGF21 expression is strongly induced in animal and human subjects with metabolic diseases, but little is known about the molecular mechanism. Endoplasmic reticulum (ER stress plays an essential role in metabolic homeostasis and is observed in numerous pathological processes, including type 2 diabetes, overweight, nonalcoholic fatty liver disease (NAFLD. In this study, we investigate the correlation between the expression of FGF21 and ER stress. We demonstrated that TG-induced ER stress directly regulated the expression and secretion of FGF21 in a dose- and time-dependent manner. FGF21 is the target gene for activating transcription factor 4 (ATF4 and CCAAT enhancer binding protein homologous protein (CHOP. Suppression of CHOP impaired the transcriptional activation of FGF21 by TG-induced ER stress in CHOP−/− mouse primary hepatocytes (MPH, and overexpression of ATF4 and CHOP resulted in FGF21 promoter activation to initiate the transcriptional programme. In mRNA stability assay, we indicated that ER stress increased the half-life of mRNA of FGF21 significantly. In conclusion, FGF21 expression is regulated by ER stress via ATF- and CHOP-dependent transcriptional mechanism and posttranscriptional mechanism, respectively.

Nickel hydrogen multicell common pressure vessel battery development update

Science.gov (United States)

Zagrodnik, Jeffrey P.; Jones, Kenneth R.

1992-01-01

The technology background and design qualification of the multicell common pressure vessel nickel hydrogen battery are described. The results of full flight qualification, including random vibration at 19.5 g for two minutes in each axis, electrical characterization in a thermal vacuum chamber, and mass spectroscopy vessel leak detection are reviewed and 12.7 cm qualification and 25.4 cm design adaptation are discussed.

Down-regulation of ATF2 in the inhibition of T-2-toxin-induced chondrocyte apoptosis by selenium chondroitin sulfate nanoparticles

Science.gov (United States)

Han, Jing; Guo, Xiong

2013-12-01

Selenium chondroitin sulfate nanoparticles (SeCS) with a size range of 30-200 nm were obtained in our previous study. Meanwhile, the up-regulated expression of ATF2 mRNA and protein levels could be observed in the cartilage from Kashin-Beck disease (KBD) patients. In this paper, we investigated the inhibition effect of SeCS on T-2-toxin-induced apoptosis of chondrocyte from KBD patients. Here, we found that when the chondrocytes were treated with T-2 toxin, the chondrocyte apoptosis performed in a concentration-dependent manner. The apoptosis of chondrocyte induced by T-2 toxin involved the increased levels of ATF2, JNK and p38 mRNAs and related protein expression. SeCS could partly block the T-2-toxin-induced chondrocyte apoptosis by decreasing the expression of ATF2, JNK and p38 mRNAs and p-JNK, p-38, ATF2 and p-ATF2 proteins. JNK and p38 pathways involved in the apoptosis of chondrocyte induced by T-2 toxin, and SeCS was efficient in the inhibition of chondrocyte apoptosis by T-2 toxin. These results suggested that SeCS had a potential for further prevention and treatment for KBD as well as other selenium deficiency disease.

Trajectory planning of tokamak flexible in-vessel inspection robot

Energy Technology Data Exchange (ETDEWEB)

Wang, Hesheng [Department of Automation, Shanghai Jiao Tong University, 200240 Shanghai (China); Key Laboratory of System Control and Information Processing, Ministry of Education of China, 200240 Shanghai (China); Chen, Weidong, E-mail: wdchen@sjtu.edu.cn [Department of Automation, Shanghai Jiao Tong University, 200240 Shanghai (China); Key Laboratory of System Control and Information Processing, Ministry of Education of China, 200240 Shanghai (China); Lai, Yinping; He, Tao [Department of Automation, Shanghai Jiao Tong University, 200240 Shanghai (China); Key Laboratory of System Control and Information Processing, Ministry of Education of China, 200240 Shanghai (China)

2015-10-15

Highlights: • A tokamak flexible in-vessel inspection robot is designed. • Two trajectory planning methods are used to ensure the full coverage of the first wall scanning. • The method is tested on a simulated platform of EAST with the flexible in-vessel inspection robot. • Experimental results show the effectiveness of the proposed algorithm. - Abstract: Tokamak flexible in-vessel inspection robot is mainly designed to carry a camera for close observation of the first wall of the vacuum vessel, which is essential for the maintenance of the future tokamak reactor without breaking the working condition of the vacuum vessel. A tokamak flexible in-vessel inspection robot is designed. In order to improve efficiency of the remote maintenance, it is necessary to design a corresponding trajectory planning algorithm to complete the automatic full coverage scanning of the complex tokamak cavity. Two different trajectory planning methods, RS (rough scanning) and FS (fine scanning), according to different demands of the task, are used to ensure the full coverage of the first wall scanning. To quickly locate the damage position, the first trajectory planning method is targeted for quick and wide-ranging scan of the tokamak D-shaped section, and the second one is for careful observation. Furthermore, both of the two different trajectory planning methods can ensure the full coverage of the first wall scanning with an optimal end posture. The method is tested on a simulated platform of EAST (Experimental Advanced Superconducting Tokamak) with the flexible in-vessel inspection robot, and the results show the effectiveness of the proposed algorithm.

Trajectory planning of tokamak flexible in-vessel inspection robot

International Nuclear Information System (INIS)

Wang, Hesheng; Chen, Weidong; Lai, Yinping; He, Tao

2015-01-01

Highlights: • A tokamak flexible in-vessel inspection robot is designed. • Two trajectory planning methods are used to ensure the full coverage of the first wall scanning. • The method is tested on a simulated platform of EAST with the flexible in-vessel inspection robot. • Experimental results show the effectiveness of the proposed algorithm. - Abstract: Tokamak flexible in-vessel inspection robot is mainly designed to carry a camera for close observation of the first wall of the vacuum vessel, which is essential for the maintenance of the future tokamak reactor without breaking the working condition of the vacuum vessel. A tokamak flexible in-vessel inspection robot is designed. In order to improve efficiency of the remote maintenance, it is necessary to design a corresponding trajectory planning algorithm to complete the automatic full coverage scanning of the complex tokamak cavity. Two different trajectory planning methods, RS (rough scanning) and FS (fine scanning), according to different demands of the task, are used to ensure the full coverage of the first wall scanning. To quickly locate the damage position, the first trajectory planning method is targeted for quick and wide-ranging scan of the tokamak D-shaped section, and the second one is for careful observation. Furthermore, both of the two different trajectory planning methods can ensure the full coverage of the first wall scanning with an optimal end posture. The method is tested on a simulated platform of EAST (Experimental Advanced Superconducting Tokamak) with the flexible in-vessel inspection robot, and the results show the effectiveness of the proposed algorithm.

The LACARA Vacuum Laser Accelerator Experiment: Beam Positioning and Alignment in a Strong Magnetic Field

International Nuclear Information System (INIS)

Shchelkunov, Sergey V.; Marshall, T. C.; Hirshfield, J. L.; Wang, Changbiao; LaPointe, M. A.

2006-01-01

LACARA (laser cyclotron auto-resonance accelerator) is a vacuum laser accelerator of electrons that is under construction at the Accelerator Test Facility (ATF), Brookhaven National Laboratory. It is expected that the experiment will be assembled by September 2006; this paper presents progress towards this goal. According to numerical studies, as an electron bunch moves along the LACARA solenoidal magnetic field (∼5.2 T, length ∼1 m), it will be accelerated from 50 to ∼75 MeV by interacting with a 0.8 TW Gaussian-mode circularly polarized optical pulse provided by the ATF CO2 10.6μm laser system. The LACARA laser transport optics must handle 10 J and be capable of forming a Gaussian beam inside the solenoid with a 1.4 mm waist and a Rayleigh range of 60 cm. The electron optics must transport a bunch having input emittance of 0.015 mm-mrad and 100 μm waist through the magnet. Precision alignment between the electron beam and the solenoid magnetic axis is required, and a method to achieve this is described in detail. Emittance- filtering may be necessary to yield an accelerated bunch having a narrow (∼1%) energy-spread

Distinct Residues Contribute to Motility Repression and Autoregulation in the Proteus mirabilis Fimbria-Associated Transcriptional Regulator AtfJ.

Science.gov (United States)

Bode, Nadine J; Chan, Kun-Wei; Kong, Xiang-Peng; Pearson, Melanie M

2016-08-01

Proteus mirabilis contributes to a significant number of catheter-associated urinary tract infections, where coordinated regulation of adherence and motility is critical for ascending disease progression. Previously, the mannose-resistant Proteus-like (MR/P) fimbria-associated transcriptional regulator MrpJ has been shown to both repress motility and directly induce the transcription of its own operon; in addition, it affects the expression of a wide range of cellular processes. Interestingly, 14 additional mrpJ paralogs are included in the P. mirabilis genome. Looking at a selection of MrpJ paralogs, we discovered that these proteins, which consistently repress motility, also have nonidentical functions that include cross-regulation of fimbrial operons. A subset of paralogs, including AtfJ (encoded by the ambient temperature fimbrial operon), Fim8J, and MrpJ, are capable of autoinduction. We identified an element of the atf promoter extending from 487 to 655 nucleotides upstream of the transcriptional start site that is responsive to AtfJ, and we found that AtfJ directly binds this fragment. Mutational analysis of AtfJ revealed that its two identified functions, autoregulation and motility repression, are not invariably linked. Residues within the DNA-binding helix-turn-helix domain are required for motility repression but not necessarily autoregulation. Likewise, the C-terminal domain is dispensable for motility repression but is essential for autoregulation. Supported by a three-dimensional (3D) structural model, we hypothesize that the C-terminal domain confers unique regulatory capacities on the AtfJ family of regulators. Balancing adherence with motility is essential for uropathogens to successfully establish a foothold in their host. Proteus mirabilis uses a fimbria-associated transcriptional regulator to switch between these antagonistic processes by increasing fimbrial adherence while simultaneously downregulating flagella. The discovery of multiple

Latest Performance Results from the FONT5 Intra-train Beam Position and Angle Feedback System at ATF2

CERN Document Server

Christian, G B; Bett, D R; Blaskovic Kraljevic, N; Burrows, P N; Davis, M R; Gerbershagen, A; Perry, C; Constance, B; Resta-Lopez, J

2012-01-01

A prototype Interaction Point beam-based feedback system for future electron-positron colliders, such as the International Linear Collider, has been designed and tested on the extraction line of the KEK Accelerator Test Facility (ATF). The FONT5 intra-train feedback system aims to stabilize the beam orbit by correcting both the position and angle jitter in the vertical plane on bunch-tobunch time scales, providing micron-level stability at the entrance to the ATF2 final-focus system. The system comprises three stripline beam position monitors (BPMs) and two stripline kickers, custom low-latency analogue front-end BPM processors, a custom FPGA-based digital processing board with fast ADCs, and custom kickerdrive amplifiers. The latest results from beam tests at ATF2 will be presented, including the system latency and correction performance.

FIR interferometer and scattering measurements of ATF

International Nuclear Information System (INIS)

Ma, C.H.; Hutchinson, D.P.; Fockedey, Y.; Vander Sluis, K.L.; Bennett, C.A.

1989-01-01

A 15-channel far-infrared (FIR) interferometer system has been constructed to measure the electron densities on the ATF plasmas. The system consists of a pair of cw 214-μm difluoromethane (CH 2 F 2 ) lasers, optically pumped by separate CO 2 lasers. The large number of channels is achieved by the use of reflective beam expansion optics to create a beam of 2 cm /times/ 45 cm. After passing through the plasma discharge, the elongated beam produced by the cylindrical mirrors is dissected by an array of 15 off-axis paraboloid reflectors, each of which illuminates a single Schottky-diode detector. The use of the beam expanding optics system reduces the number of optical elements required for the interferometer to approximately 2-3 per channel. The FIR laser beams are transported from the laser room to the experimental area by 25 mm i.d. dielectric waveguides purged with dry nitrogen. The system can also be operated at a wavelength of 119-μm by changing the gas in FIR laser cavities to methanol for high density experiments. Details of the system are described. A study is underway to determine the optimum design of a FIR scattering system for the ATF. This scattering system will be used to investigate density fluctuations with scale lengths from 0.1 cm to the plasma radius. The laser for this scattering system may be operated at wavelengths of 447, 307, 214, 184, and 119 μm with power levels of 100 to 500 mW. A summary of the study is presented. 6 refs., 1 fig

The Brookhaven ATF low-emittance beam line

International Nuclear Information System (INIS)

Wang, X.J.; Kirk, H.G.

1991-01-01

One component of the experimental program at the Brookhaven Accelerator Test Facility (ATF) consists of a class of experiments which will study the acceleration of electrons through micron-size structures which are exposed in coincidence to a 100 GW CO 2 laser beam. These experiments require the development and control of an electron beam with geometric emittances on the order of 10 -10 m-rad and intensities on the order of 10 6 electrons. In this paper, the authors describe the strategies for producing such beams and the effects of higher-order aberrations. Particle tracking results are presented for the final-focus system

The Insulation Vacuum Barrier for the Large Hadron Collider (LHC) Magnet Cryostats

CERN Document Server

Castoldi, M; Parma, Vittorio; Skoczen, Blazej; Trilhe, P

2000-01-01

The sectorisation of the insulation vacuum of the LHC magnet cryostats, housing the superconducting magnets, which operate in a 1.9 K superfluid helium bath, is achieved by means of vacuum barriers. Each vacuum barrier is a leak-tight austenitic stainless steel thin-wall structure, mainly composed of large diameter (between 0.6 m and 0.9 m) bellows and concentric corrugated cylinders. It is mounted in the Short Straight Section (SSS) [1], between the magnet helium enclosure and the vacuum vessel. This paper presents the design of the vacuum barrier, concentrating mostly on its expected thermal performance, to fulfil the tight LHC heat in-leak budgets. Pressure and leak test results, confirming the mechanical design of two prototypes manufactured in industry, and the preparation of one of these vacuum barriers for cryogenic testing in an SSS prototype, are also mentioned.

Fast wave heating experiments in the ion cyclotron range of frequencies on ATF

Energy Technology Data Exchange (ETDEWEB)

Kwon, M; Shepard, T D; Goulding, R H [Oak Ridge National Lab., TN (United States); and others

1992-07-01

Fast wave heating experiments in the ion cyclotron range of frequencies (ICRF) were performed on target plasmas produced by 350 kW of electron cyclotron heating at 53 GHz and also by neutral beam injection in the Advanced Toroidal Facility (ATF). Various heating regimes were investigated in the frequency range between 9.2 MHz and 28.8 MHz with magnetic fields of 0.95 T and 1.9 T on axis. The nominal pulse lengths of up to 200 kW RF power were in the range between 100 and 400 ms. Data from spectroscopy, loading measurements, and edge RF and Langmuir probes were used to characterize the RF induced effects on the ATF plasma. In the hydrogen minority regime at low plasma density, large suprathermal ion tails were observed with a neutral particle analyser. At high density (n-bar{sub e} {>=} 5.0 x 10{sup 13} cm{sup -3}) substantial increases in antenna loading were observed, but ICRF power was insufficient to produce definitive heating results. A two-dimensional RF heating code, ORION, and a Fokker-Planck code, RFTRANS, were used to simulate these experiments. A simulation of future high power, higher density experiments in ATF indicates improved bulk heating results due to the improved loading and more efficient thermalization of the minority tail. (author). 29 refs, 16 figs, 3 tabs.

Heat dissipation research on the water-cooling channel of HL-2M in-vessel coils

Energy Technology Data Exchange (ETDEWEB)

Jiang, J., E-mail: jiangjiaming@swip.ac.cn; Liu, Y.; Chen, Q.; Ji, X.Q.

2017-04-15

Highlights: • The joule heat of in-vessel coils is very difficult to dissipate inside HL-2M vacuum vessel. • Heat dissipation model of the coil includes the joule heat model, the heat conduction model and the heat transfer model. • The CFD analysis has been done for the coil-water cooling, with comparison with the date of theoretical analysis and experiment. • The result shows water-cooling channel is good for the joule heat transfer and taken away. - Abstract: HL-2M in-vessel coils are positioned in high vacuum circumstance, and they will generate joule heat when they carry 15 kA electrical current, but joule heat is very difficult to dissipate in vacuum, so a hollow cable with 8 mm inner diameter is design as water-cooling channel for heat convection. By using the methods of the theoretical derivation, together with CFD numeric simulation method and the experiment of the heat transfer, the water channel of HL-2M in-vessel coils has been studied, and the temperature of HL-2M in-vessel coils under different cooling water flow rates is obtained and acceptable. Simultaneously, the external cooling water supply system parameters for the water-cooling channel of the coils are estimated. Three methods’ results are in good agreement; the theoretical model is verified and could be popularized for predicting the temperature rise of HL-2M in-vessel coils.

Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation

International Nuclear Information System (INIS)

Kim, Kook Hwan; Jeong, Yeon Taek; Kim, Seong Hun; Jung, Hye Seung; Park, Kyong Soo; Lee, Hae-Youn; Lee, Myung-Shik

2013-01-01

Highlights: •Metformin induces FGF21 expression in an AMPK independent manner. •Metformin enhances FGF21 expression by inhibiting mitochondrial complex I activity. •The PERK-eIF2α-ATF4 axis is required for metformin-induced FGF21 expression. •Metformin activates the ATF4-FGF21 axis in the liver of mouse. •Metformin increases serum FGF21 level in diabetic human subjects. -- Abstract: Fibroblast growth factor 21 (FGF21) is an endocrine hormone that exhibits anti-obesity and anti-diabetes effects. Because metformin is widely used as a glucose-lowering agent in patients with type 2 diabetes (T2D), we investigated whether metformin modulates FGF21 expression in cell lines, and in mice or human subjects. We found that metformin increased the expression and release of FGF21 in a diverse set of cell types, including rat hepatoma FaO, primary mouse hepatocytes, and mouse embryonic fibroblasts (MEFs). Intriguingly, AMP-activated protein kinase (AMPK) was dispensable for the induction of FGF21 by metformin. Mammalian target of rapamycin complex 1 (mTORC1) and peroxisome proliferator-activated receptor α (PPARα), which are additional targets of metformin, were not involved in metformin-induced FGF21 expression. Importantly, inhibition of mitochondrial complex I activity by metformin resulted in FGF21 induction through PKR-like ER kinase (PERK)-eukaryotic translation factor 2α (eIF2α)-activating transcription factor 4 (ATF4). We showed that metformin activated ATF4 and increased FGF21 expression in the livers of mice, which led to increased serum levels of FGF21. We also found that serum FGF21 level was increased in human subjects with T2D after metformin therapy for 6 months. In conclusion, our results indicate that metformin induced expression of FGF21 through an ATF4-dependent mechanism by inhibiting mitochondrial respiration independently of AMPK. Therefore, FGF21 induction by metformin might explain a portion of the beneficial metabolic effects of metformin

Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation

Energy Technology Data Exchange (ETDEWEB)

Kim, Kook Hwan [Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong Gangnam-gu, Seoul 135-710 (Korea, Republic of); Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University School of Medicine, 50 Irwon-dong Gangnam-gu, Seoul 135-710 (Korea, Republic of); Jeong, Yeon Taek [Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong Gangnam-gu, Seoul 135-710 (Korea, Republic of); Kim, Seong Hun [Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University School of Medicine, 50 Irwon-dong Gangnam-gu, Seoul 135-710 (Korea, Republic of); Jung, Hye Seung; Park, Kyong Soo [Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong Chongno-gu, Seoul 110-744 (Korea, Republic of); Lee, Hae-Youn [Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong Gangnam-gu, Seoul 135-710 (Korea, Republic of); Lee, Myung-Shik, E-mail: mslee0923@skku.edu [Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong Gangnam-gu, Seoul 135-710 (Korea, Republic of); Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University School of Medicine, 50 Irwon-dong Gangnam-gu, Seoul 135-710 (Korea, Republic of)

2013-10-11

Highlights: •Metformin induces FGF21 expression in an AMPK independent manner. •Metformin enhances FGF21 expression by inhibiting mitochondrial complex I activity. •The PERK-eIF2α-ATF4 axis is required for metformin-induced FGF21 expression. •Metformin activates the ATF4-FGF21 axis in the liver of mouse. •Metformin increases serum FGF21 level in diabetic human subjects. -- Abstract: Fibroblast growth factor 21 (FGF21) is an endocrine hormone that exhibits anti-obesity and anti-diabetes effects. Because metformin is widely used as a glucose-lowering agent in patients with type 2 diabetes (T2D), we investigated whether metformin modulates FGF21 expression in cell lines, and in mice or human subjects. We found that metformin increased the expression and release of FGF21 in a diverse set of cell types, including rat hepatoma FaO, primary mouse hepatocytes, and mouse embryonic fibroblasts (MEFs). Intriguingly, AMP-activated protein kinase (AMPK) was dispensable for the induction of FGF21 by metformin. Mammalian target of rapamycin complex 1 (mTORC1) and peroxisome proliferator-activated receptor α (PPARα), which are additional targets of metformin, were not involved in metformin-induced FGF21 expression. Importantly, inhibition of mitochondrial complex I activity by metformin resulted in FGF21 induction through PKR-like ER kinase (PERK)-eukaryotic translation factor 2α (eIF2α)-activating transcription factor 4 (ATF4). We showed that metformin activated ATF4 and increased FGF21 expression in the livers of mice, which led to increased serum levels of FGF21. We also found that serum FGF21 level was increased in human subjects with T2D after metformin therapy for 6 months. In conclusion, our results indicate that metformin induced expression of FGF21 through an ATF4-dependent mechanism by inhibiting mitochondrial respiration independently of AMPK. Therefore, FGF21 induction by metformin might explain a portion of the beneficial metabolic effects of metformin.

Remote maintenance of in-vessel components in Tokamak Fusion Test Reactor

International Nuclear Information System (INIS)

Loesser, G.D.; Heitzenroeder, P.; Kungl, D.; Dylla, H.F.; Cerdan, G.

1990-01-01

The Tokamak Fusion Test Reactor (TFTR) will generate a total of 3 x 10 21 neutrons during its planned D-T operational period. A maintenance manipulator has been designed and tested to minimize personnel radiation during in-vessel maintenance activities. Its functions include visual inspection, first-wall tile replacement, cleaning, diagnostics calibrations and leak detection. To meet these objectives, the TFTR maintenance manipulator is required to be operable in the TFTR high vacuum environment, typically -8 torr, ( -6 Pa). Geometrically, the manipulator must extend 180 0 in either direction around the torus to assure complete coverage of the vessel first-wall. The manipulator consists of a movable carriage, and movable articulated link sections which are driven by electrical actuators. The boom has vertical load capacity of 455 kg and lateral load capacity of 46 kg. The boom can either be fitted with a general inspection arm or dextrous slave arms. The general inspection arm is designed to hold the leak detector and an inspection camera; it is capable of rotation along two axes and has a linkage system which permits motion normal to the vacuum vessel wall. All systems except the dextrous slave arms are operable in a vacuum. (author)

Application of ion scattering spectrometers for the observation of process of cleaning of surfaces of materials for vacuum vessel

International Nuclear Information System (INIS)

Akashi, Ken-ya; Miyahara, Akira; Sagara, Akio.

1978-01-01

The impurity gas emitted from the surfaces of vacuum vessels was investigated by using the shadowing effect of the covering atoms. The ion scattering spectrometer used for the experiment consists of an ion source, a test sample, an energy analyzer and an ion detector. The evacuation system comprises a turbomolecular pump, a Ti-sublimation pump and an ion pump. The achieved final gas pressure is 5 x 10 -10 Torr. The ion beam intensity to a sample is 10 micro ampere/cm 2 , and the ion energy is about 1 to 1.5 keV. The quantity of oxygen on the surface of a sample molybdenum was measured in the process of evacuation. The concentration of surface oxygen decreased with the gas pressure of the system. It was found that residual oxygen was observed after the sputter etching with Ar ion impact on the surface. The reason of this residual oxygen was considered. (Kato, T.)

Vacuum exhaustion system for thermonuclear reactor and cryopump thereof

International Nuclear Information System (INIS)

Kobayashi, Shigetada.

1992-01-01

An impurity removing device is connected to a gas exhaust side of a plasma vacuum vessel by way of a gate valve, a cryopump is connected to the exit side of the device by way of an exit valve, a fuel transfer line is disposed for transferring fuels to a fuel purification system and a vacuum pump line is disposed to an exhaust gas line. Further, a tritium monitor is disposed to an exhaustion line and the line on the side of the exit of the monitor is branched into two ways, in which a tritium transfer pipe is disposed to one of them and an atmosphere release pipe is disposed on the other of them by way of an atmosphere releasing valve. Further, a condensation shebron is disposed for flowing in and out fuel isotope gases discharged from the plasma vacuum vessel, and a funnel discharge pipe is disposed for discharging a liquefied and condensed fluid. Since the gases to be exhausted are liquefied and condensed without coagulation or coagulation products are removed while operating the pump, the exhaust gases are processed continuously to reduce tritium inventory and make the regeneration step unnecessary and remarkably improve the heat efficiency. (N.H.)

Electromagnetic and structural analyses of the vacuum vessel and plasma facing components for EAST

International Nuclear Information System (INIS)

Xu, Weiwei; Liu, Xufeng; Song, Yuntao; Li, Jun; Lu, Mingxuan

2013-01-01

Highlights: • The electromagnetic and structural responses of VV and PFCs for EAST are analyzed. • A detailed finite element model of the VV including PFCs is established. • The two most dangerous scenarios, major disruptions and downward VDEs are considered. • The distribution patterns of eddy currents, EMFs and torques on PFCs are analyzed. -- Abstract: During plasma disruptions, time-varying eddy currents are induced in the vacuum vessel (VV) and Plasma Facing Components (PFCs) of EAST. Additionally, halo currents flow partly through these structures during the vertical displacement events (VDEs). Under the high magnetic field circumstances, the resulting electromagnetic forces (EMFs) and torques are large. In this paper, eddy currents and EMFs on EAST VV, PFCs and their supports are calculated by analytical and numerical methods. ANSYS software is employed to evaluate eddy currents on VV, PFCs and their structural responses. To learn the electromagnetic and structural response of the whole structure more accurately, a detailed finite element model is established. The two most dangerous scenarios, major disruptions and downward VDEs, are examined. It is found that distribution patterns of eddy currents for various PFCs differ greatly, therefore resulting in different EMFs and torques. It can be seen that for certain PFCs the transient reaction force are severe. Results obtained here may set up a preliminary foundation for the future dynamic response research of EAST VV and PFCs which will provide a theoretical basis for the future engineering design of tokamak devices

v-src Induction of the TIS10/PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element

Energy Technology Data Exchange (ETDEWEB)

Xie, W.; Fletcher, B.S.; Andersen, R.D.; Herschman, H.R. [Univ. of California, Los Angeles, CA (United States)

1994-10-01

The authors recently reported the cloning of a mitogen-inducible prostaglandin synthase gene, TIS10/PGS2. In addition to growth factor and tumor promoters, the v-src oncogene induces TIS10/PGS2 expression in 3T3 cells. Deletion analysis, using luciferase reporters, identifies a region between -80 and -40 nucleotides 5{prime} of the TIS10/PGS2 transcription start site that mediates pp60{sup v-src} induction in 3T3 cells. This region contains the sequence CGTCACGTG, which includes overlapping ATF/CRE (CGTCA) and E-box (CACGTG) sequences. Gel shift-oligonucleotide competition experiments with nuclear extracts from cells stably transfected with a temperature-sensitive v-src gene demonstrate that the CGTCACGTG sequence can bind proteins at both the AFT/CRE and E-box sequences. Dominant-negative CREB and Myc proteins that bind DNA, but do not transactivate, block v-src induction of a luciferase reporter driven by the first 80 nucleotides of the TIS10/PGS2 promoter. Mutational analysis distinguishes which TIS10/PGS2 cis-acting element mediates pp60{sup v-src} induction. E-box mutation has no effect on the fold induction in response to pp60{sup v-src}. In contrast, ATF/CRE mutation attenuates the pp{sup v-src} response. Antibody supershift and methylation interference experiments demonstrate that CREB and at least one other ATF transcription factor in these extracts bind to the TIS10/PGS2 ATF/CRE element. Expression of a dominant-negative ras gene also blocks TIS10/PGS2 induction by v-src. The data suggest that Ras mediates pp60{sup v-src} activation of an ATF transcription factor, leading to induced TIS10/PGS2 expression via the ATF/CRE element of the TIS10/PGS2 promoter. This is the first description of v-src activation of gene expression via an ATF/CRE element. 64 refs., 8 figs.

Larval hemolymph of rhinoceros beetle, Allomyrina dichotoma, enhances insulin secretion through ATF3 gene expression in INS-1 pancreatic β-cells.

Science.gov (United States)

Kim, Seung-Whan; Suh, Hyun-Woo; Yoo, Bo-Kyung; Kwon, Kisang; Yu, Kweon; Choi, Ji-Young; Kwon, O-Yu

2018-05-22

In this study, we show that INS-1 pancreatic β-cells treated for 2 h with hemolymph of larvae of rhinoceros beetle, Allomyrina dichotoma, secreted about twice as much insulin compared to control cells without such treatment. Activating transcription factor 3 (ATF3) was the highest upregulated gene in DNA chip analysis. The A. dichotoma hemolymph dose-dependently induced increased expression levels of genes encoding ATF3 and insulin. Conversely, treatment with ATF3 siRNA inhibited expression levels of both genes and curbed insulin secretion. These results suggest that the A. dichotoma hemolymph has potential for treating and preventing diabetes or diabetes-related complications.

ITER diagnostic system: Vacuum interface

Energy Technology Data Exchange (ETDEWEB)

Patel, K.M., E-mail: Kaushal.Patel@iter.org [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-Lez-Durance (France); Udintsev, V.S.; Hughes, S.; Walker, C.I.; Andrew, P.; Barnsley, R.; Bertalot, L. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-Lez-Durance (France); Drevon, J.M. [Bertin Technologies, BP 22, 13762 Aix-en Provence cedex 3 (France); Encheva, A. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-Lez-Durance (France); Kashchuk, Y. [Institution “PROJECT CENTER ITER”, 1, Akademika Kurchatova pl., Moscow (Russian Federation); Maquet, Ph. [Bertin Technologies, BP 22, 13762 Aix-en Provence cedex 3 (France); Pearce, R.; Taylor, N.; Vayakis, G.; Walsh, M.J. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-Lez-Durance (France)

2013-10-15

Diagnostics play an essential role for the successful operation of the ITER tokamak. They provide the means to observe control and to measure plasma during the operation of ITER tokamak. The components of the diagnostic system in the ITER tokamak will be installed in the vacuum vessel, in the cryostat, in the upper, equatorial and divertor ports, in the divertor cassettes and racks, as well as in various buildings. Diagnostic components that are placed in a high radiation environment are expected to operate for the life of ITER. There are approx. 45 diagnostic systems located on ITER. Some diagnostics incorporate direct or independently pumped extensions to maintain their necessary vacuum conditions. They require a base pressure less than 10{sup −7} Pa, irrespective of plasma operation, and a leak rate of less than 10{sup −10} Pa m{sup 3} s{sup −1}. In all the cases it is essential to maintain the ITER closed fuel cycle. These directly coupled diagnostic systems are an integral part of the ITER vacuum containment and are therefore subject to the same design requirements for tritium and active gas confinement, for all normal and accidental conditions. All the diagnostics, whether or not pumped, incorporate penetration of the vacuum boundary (i.e. window assembly, vacuum feedthrough etc.) and demountable joints. Monitored guard volumes are provided for all elements of the vacuum boundary that are judged to be vulnerable by virtue of their construction, material, load specification etc. Standard arrangements are made for their construction and for the monitoring, evacuating and leak testing of these volumes. Diagnostic systems are incorporated at more than 20 ports on ITER. This paper will describe typical and particular arrangements of pumped diagnostic and monitored guard volume. The status of the diagnostic vacuum systems, which are at the start of their detailed design, will be outlined and the specific features of the vacuum systems in ports and extensions

ITER diagnostic system: Vacuum interface