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Sample records for astatine 219

  1. Organic chemistry of astatine

    International Nuclear Information System (INIS)

    The paper surveys the investigations on the chemical behaviour of astatine in organic systems and deals with the preparation and identification of its organic compounds. A discussion is given on some of the physico-chemical properties of these compounds determined by extrapolation techniques as well as by direct measurement. The biomedical importance of 211At-labelled compounds is briefly referred to. (authors)

  2. Bibliography of astatine chemistry and biomedical applications

    International Nuclear Information System (INIS)

    An overall bibliography is presented on astatine chemistry and on the biomedical applications of its 211At isotope. The references were grouped in the following chapters: General reviews; Discovery, Natural Occurence; Nuclear Data; Preparation, Handling, Radiation Risk; Physico-chemical Properties; Astatine Compounds and Chemical Reactions; Biological Effects and Applications. Entries are sorted alphabetically by authors name in each chapter, and cross-references to other chapters are provided if appropriate. (R.P.)

  3. Astatine-211: production and availability.

    Science.gov (United States)

    Zalutsky, Michael R; Pruszynski, Marek

    2011-07-01

    The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211 can be produced in reasonable yield from natural bismuth targets via the (209)Bi(α,2n)(211)At nuclear reaction utilizing straightforward methods. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of (210)At, which is problematic because of its 138.4-day half life α-particle emitting daughter, (210)Po. The intrinsic cost for producing (211)At is reasonably modest and comparable to that of commercially available (123)I. The major impediment to (211)At availability is attributed to the need for a medium energy α-particle beam for its production. On the other hand, there are about 30 cyclotrons in the world that have the beam characteristics required for (211)At production. PMID:22201707

  4. Recent advances in the organic chemistry of astatine

    International Nuclear Information System (INIS)

    Investigation on the chemical behaviour of astatine in the last decade are surveyed. The survey covers the physical and chemical properties of astatine, synthesis and identification of organic astatine compounds, their physicochemical properties. A special chapter is devoted to biomedical applications, including inorganic 211At species, 211At-labelled proteins and drugs. An extensive bibliography of the related literature is given. (N.T.) 129 refs.; 12 figs.; 14 tabs

  5. Dosimetrical considerations in astatine-211 radioimmunotherapy

    International Nuclear Information System (INIS)

    Several dosimetrical quantities have been suggested for use in alpha-particle dosimetry. To evaluate the expected biological effect when using these quantities, a Monte Carlo program was set to register the single-event distribution of both specific energy and alpha-particle track length to a cell nucleus (r=5.6 μm). Distributions were acquired for both 'bound' (simulating the effect of 211At-labelled antibodies bound to antigens on cell surfaces (r=7.0 μm)) as well as 'non-bound' (simulating 211At-labelled antibodies that have not bound to a cell) astatine-211. From these distributions, various theoretical cell survival curves were established for 3 different dosimetrical quantities, i.e. specific energy, number of alpha-particle hits and total track length. The survival curves for all quantities are presented for the corresponding mean absorbed dose in order to facilitate comparisons of the expected effects of using the 3 different quantities for both distributions of 211At decays. The theoretical survival curves presented here could, combined with experiments using 'bound' and 'non-bound' 211At in a single-cell suspension, reveal which dosimetrical quantity is most suitable for 211 At-radioimmunotherapy. (author)

  6. Discovery of the astatine, radon, francium, and radium isotopes

    OpenAIRE

    Fry, C; Thoennessen, M

    2012-01-01

    Currently, thirty-nine astatine, thirty-nine radon, thirty-five francium, and thirty-four radium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  7. Extraction of astatine isotopes for development of radiopharmaceuticals using a 211Rn-211At generator

    International Nuclear Information System (INIS)

    In order to utilize a 211At isotope, a promising α-emitter for radionuclide therapy, the chemical properties of astatine isotopes are studied. We have examined wet chemistry methods through the distribution ratios of astatine in liquid-liquid extraction. The astatine isotopes have been found to be well extracted into DIPE and MIBK. We observed that the distribution ratio of astatine isotopes increases with concentrations of HCl greater than 3 M, while it decreases with the HCl concentration less than 2 M. The results will be useful for development of the 211Rn-211At generator. (author)

  8. Astatine-211-Labeled Targeted Radiotherapeutics: An Update

    International Nuclear Information System (INIS)

    The heavy halogen 211At was first proposed for use in α-particle targeted radiotherapy more than 30 years ago and continues to be one of the most promising radionuclides for this purpose. Although its 7.2-h half life is not ideal for intravenously administered whole antibodies, it is compatible with the pharmacokinetics of antibody fragments, peptides, aptamers and organic molecules. Its diverse chemistry allows its incorporation into a wide array of targeting vehicles, relying on its chemical similarity to iodine to provide a useful point of departure. On the other hand, the relatively low carbon-astatine bond strength is challenging. In common with the other α-emitters being discussed at this symposium, lack of reliable availability is one of the biggest hurdles in the use of 211At for targeted radiotherapy. However, in the case of 211At, it is not a question of production cost or availability of target material, because 211At can be produced in reasonable yield from natural bismuth targets. Rather, the difficulty is the lack of cyclotrons equipped with the medium energy α-particle beams required for its production. If the infrastructure for producing 211At is to be improved to the stage where 211At-labeled radiopharmaceuticals can have a meaningful impact, several developments must occur. First, the ability to produce clinically relevant levels of 211At that can be shipped to remote locations in chemically tractable form must be demonstrated. Approaches under consideration include compensating for radiolysis-mediated effects and the consideration of alternative chemistries. Second, strategies for compensating for heterogeneities in dose deposition must be developed, hopefully in a way that is compatible with approval for human use. And third, it is essential that more clinical trials be performed with 211At-labeled therapeutics, particularly in settings of minimum residual disease where the radiobiological advantages of α-particles can be best exploited. Our

  9. Scrutinizing "Invisible" astatine: A challenge for modern density functionals.

    Science.gov (United States)

    Sergentu, Dumitru-Claudiu; David, Grégoire; Montavon, Gilles; Maurice, Rémi; Galland, Nicolas

    2016-06-01

    The main-group 6p elements did not receive much attention in the development of recent density functionals. In many cases it is still difficult to choose among the modern ones a relevant functional for various applications. Here, we illustrate the case of astatine species (At, Z = 85) and we report the first, and quite complete, benchmark study on several properties concerning such species. Insights on geometries, transition energies and thermodynamic properties of a set of 19 astatine species, for which reference experimental or theoretical data has been reported, are obtained with relativistic (two-component) density functional theory calculations. An extensive set of widely used functionals is employed. The hybrid meta-generalized gradient approximation (meta-GGA) PW6B95 functional is overall the best choice. It is worth noting that the range-separated HSE06 functional as well as the old and very popular B3LYP and PBE0 hybrid-GGAs appear to perform quite well too. Moreover, we found that astatine chemistry in solution can accurately be predicted using implicit solvent models, provided that specific parameters are used to build At cavities. © 2016 Wiley Periodicals, Inc. PMID:27059181

  10. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    CERN Document Server

    Rothe, S; Antalic, S; Borschevsky, A; Capponi, L; Cocolios, T E; De Witte, H; Eliav, E; Fedorov, D V; Fedosseev, V N; Fink, D A; Fritzsche, S; Ghys, L; Huyse, M; Imai, N; Kaldor, U; Kudryavtsev, Yu; Köster, U; Lane, J; Lassen, J; Liberati, V; Lynch, K M; Marsh, B A; Nishio, K; Pauwels, D; Pershina, V; Popescu, L; Procter, T J; Radulov, D; Raeder, S; Rajabali, M M; Rapisarda, E; Rossel, R E; Sandhu, K; Seliverstov, M D; Sjödin, A M; Van den Bergh, P; Van Duppen, P; Venhart, M; Wakabayashi, Y; Wendt K D A

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of smallest quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.317510(8) eV. New ab initio calculations were performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of super-heavy element 117, the heaviest homologue of astatine.

  11. Synthesis and Evaluation of Astatinated N-[2-(Maleimido)ethyl]-3-(trimethylstannyl)benzamide Immunoconjugates.

    Science.gov (United States)

    Aneheim, Emma; Gustafsson, Anna; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Svedhem, Sofia; Lindegren, Sture

    2016-03-16

    Effective treatment of metastasis is a great challenge in the treatment of different types of cancers. Targeted alpha therapy utilizes the short tissue range (50-100 μm) of α particles, making the method suitable for treatment of disseminated occult cancers in the form of microtumors or even single cancer cells. A promising radioactive nuclide for this type of therapy is astatine-211. Astatine-211 attached to tumor-specific antibodies as carrier molecules is a system currently under investigation for use in targeted alpha therapy. In the common radiolabeling procedure, astatine is coupled to the antibody arbitrarily on lysine residues. By instead coupling astatine to disulfide bridges in the antibody structure, the immunoreactivity of the antibody conjugates could possibly be increased. Here, the disulfide-based conjugation was performed using a new coupling reagent, maleimidoethyl 3-(trimethylstannyl)benzamide (MSB), and evaluated for chemical stability in vitro. The immunoconjugates were subsequently astatinated, resulting in both high radiochemical yield and high specific activity. The MSB-conjugate was shown to be stable with a long shelf life prior to the astatination. In a comparison of the in vivo distribution of the new immunoconjugate with other tin-based immunoconjugates in tumor-bearing mice, the MSB conjugation method was found to be a viable option for successful astatine labeling of different monoclonal antibodies. PMID:26791409

  12. Comment: 219 [Taxonomy Icon

    Lifescience Database Archive (English)

    Full Text Available Japanese medaka Oryzias latipes Oryzias_latipes_L.png 219.png Taxonomy icon (c) Database Center for Life Sci...ence licensed under CC Attribution2.1 Japan アイコン:メダカ HNI-Ⅱ系統バージョン bando 2010/02/15 15:31:07 2010/02/16 09:53:27 ...

  13. Astatine-211: production, injection into monoclonal antibodies radiological effect, possible application to cancer treatment

    International Nuclear Information System (INIS)

    Methods developed in the Laboratory of Nuclear Problems, JINR, for producing astatine-211 and injecting it into monoclonal antibodies are described. The use of its diethylene triamine penta-acetic acid complex is shown to be the most effective method of injecting astatine into a biomolecules. The biological effect of the α-particles emitted from the astatine-211 is investigated using Chinese hamster fibroblasts and Ehrlich carcinoma cells. It is established that the mitotic activity depression, number of degenerating cells, number of cells with chromosome aberrations, and cellular surviving fraction depend on the concentration of the radionuclide in the medium 'in vitro'. The RBE of α-particles in comparison with 60Co γ-rays is 3. Injection of astatine-211 absorbed on tellurium particles into mice with ascitic tumors resulted in prolongation of their life or elimination of the tumors. (author). 39 refs, 7 figs

  14. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    OpenAIRE

    Rothe, S.; A. N. Andreyev; Antalic, S; Borschevsky, A.; Capponi, L.; Cocolios, T.E.; Witte, H.; Eliav, E.; Fedorov, D. V.; Fedosseev, V. N.; Fink, D. A.; Fritzsche, S.; Ghys, L.; Huyse, M.; Imai, N.

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the io...

  15. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    Science.gov (United States)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Lindegren, Sture

    2015-07-01

    To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitted α-particles, this therapy is particularly suited to treating occult, disseminated cancers. Astatine is not intrinsically tumour-specific; therefore, it requires an appropriate tumour-specific targeting vector, which can guide the radiation to the cancer cells. Consequently, an appropriate method is required for coupling the nuclide to the vector. To increase the availability of astatine-211 radiopharmaceuticals for targeted alpha therapy, their production should be automated. Here, we present a method that combines dry distillation of astatine-211 and a synthesis module for producing radiopharmaceuticals into a process platform. This platform will standardize production of astatinated radiopharmaceuticals, and hence, it will facilitate large clinical studies focused on this promising, but chemically challenging, alpha-emitting radionuclide. In this work, we describe the process platform, and we demonstrate the production of both astaine-211, for preclinical use, and astatine-211 labelled antibodies.

  16. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    DEFF Research Database (Denmark)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Lindegren, Sture

    2015-01-01

    vector, which can guide the radiation to the cancer cells. Consequently, an appropriate method is required for coupling the nuclide to the vector. To increase the availability of astatine-211 radiopharmaceuticals for targeted alpha therapy, their production should be automated. Here, we present a method......To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical and...... challenging, alpha-emitting radionuclide. In this work, we describe the process platform, and we demonstrate the production of both astaine-211, for preclinical use, and astatine-211 labelled antibodies....

  17. Study of Astatine (III) reactions with O, S and N ligands in solution

    International Nuclear Information System (INIS)

    Full text of publication follows. Astatine (At, Z=85: [Xe]4f145d106s26p5) belongs to the halogen group and is located below iodine in the periodic table. One of its isotopes (211At) appears promising as a therapeutic agent in nuclear medicine (Ref.1) owing to the energy of the alpha particles emitted during the disintegration of its nucleus and its short physical half-life (7.2 h). Since there are no stable isotopes of astatine, the chemistry of this element remains poorly understood. Generally, At is supposed to behave as a halogen (Ref.2) but it has been shown recently in our group that astatine presents a metallic behaviour in aqueous solution: it notably exists as At+ and AtO+ species under the oxidation states +I and +III (Ref.3). At the present time, the number of studies dealing with the complexation properties of the cationic forms of astatine remains limited (Ref.4), owing to its low availability. In this work, we have investigated the reactions of AtO+ species with different hetero-atomic (N, S, O) model ligands. A combined approach based on experimental and theoretical studies has been used (Ref.5). On account of the difficulties of experimental investigations of astatine species, the reactivity of AtO+ was explored using a competition method founded on astatine distributions between two distinct phases. Furthermore, for each AtO+/ ligand complex, the nature of the species formed and the associated thermodynamic constants were determined by computational modeling (DFT calculations). In this framework, an original computational methodology was developed to take into account the specificities of astatine, notably the associated relativistic effects. The computed equilibrium constants have been confronted with the experimental results. This comparison demonstrates an outstanding coherence between experience and theory. Furthermore, the analysis of the results shows a key role of solvent effects on astatine chemistry. Lastly, a specific reactivity for the

  18. Some aspects of the organic, biological and inorganic chemistry of astatine

    International Nuclear Information System (INIS)

    Astatine has no stable isotopes and the radioactive isotopes with half-lives sufficiently long for chemical experiments (209At, 210At, 211At) must be produced artificially with a cyclotron or with a high energy accelerator by spallation of Th. This thesis deals with the synthesis and chemistry of At-compounds and the determination of some of their properties. (C.F.)

  19. Astatine-211 Pathway from Radiochemistry to Clinical Investigation

    International Nuclear Information System (INIS)

    Particularly in clinical settings where tumour burden is low and cancers are located in close proximity to essential normal tissue structures, α-particle emitting radionuclides can offer significant advantages for targeted radionuclide therapy. One of the first alpha emitters to be evaluated for this purpose is the 7.2-h half-life radiohalogen Astatine-211 (211At). From a commercialization-potential perspective 211At, is less appealing than the longer half-life alpha particle emitters Radium-223, Actinium-225 and Thorium-227, which have become the focus of many laboratories. However, if methods for providing a better supply of 211At could be developed, this alpha emitter would be the radionuclide of choice for many potential therapeutic applications. With regard to the production of 211At, this can be readily be accomplished by bombarding natural bismuth targets with 28−29.5 MeV alpha particles via the 209Bi(α,2n)211At reaction. The goal is to utilize an alpha particle beam energy that provides the required balance for maximizing 211At production while minimizing creation of 210At, which is problematic because of its 138.4-day half life alpha-particle emitting daughter, 210Po. For most intended clinical applications, alpha particle beam energy of about 29 MeV offers the best compromise between maximizing yield and providing 211At with sufficient radionuclidic purity for clinical use. Clinically relevant levels of 211At have been produced at several institutions using both internal and external cyclotron targets

  20. 22 CFR 219.160 - Communications.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Communications. 219.160 Section 219.160 Foreign... DEVELOPMENT § 219.160 Communications. (a) The agency shall take appropriate steps to ensure effective communication with applicants, participants, personnel of other Federal entities, and members of the public....

  1. 49 CFR 219.104 - Responsive action.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Responsive action. 219.104 Section 219.104..., DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Prohibitions § 219.104 Responsive action. (a... (e) of this section apply. (3)(i) This section does not apply to actions based on breath or...

  2. 33 CFR 117.219 - Pequonnock River.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Pequonnock River. 117.219 Section 117.219 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Connecticut § 117.219 Pequonnock River. (a)...

  3. 12 CFR 741.219 - Investment requirements.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Investment requirements. 741.219 Section 741.219 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS... Unions That Also Apply to Federally Insured State-Chartered Credit Unions § 741.219...

  4. An attempt to explore the production routes of Astatine radionuclides: Theoretical approach

    OpenAIRE

    Maiti, Moumita; Lahiri, Susanta

    2008-01-01

    In order to fulfil the recent thrust of Astatine radionuclides in the field of nuclear medicine various production routes have been explored in the present work. The possible production routes of $^{209-211}$At comprise both light and heavy ion induced reactions at the bombarding energy range starting from threshold to maximum 100 MeV energy. For this purpose, we have used the nuclear reaction model codes TALYS, ALICE91 and PACE-II. Excitation functions of those radionuclides, produced throug...

  5. Direct astatination of a tumour-binding protein, human epidermal growth factor, using nido-carborane as a prosthetic group

    International Nuclear Information System (INIS)

    A method for direct astatine labeling of proteins has been investigated. Binding sites for astatine were created by coupling of a nido-carborane derivative to a protein, the human epidermal growth factor (hEGF), using two different conjugation methods - by glutaraldehyde cross-linking or by introduction of sulfohydryl groups by Traut's reagent with subsequent linking of ANC-1 with m-maleimidobenzoyl-N-hydroxysulfosuccinimide ester. The conjugates were astatinated using the Chloramine-T method in high yield. The best labeling was obtained by the glutaraldehyde conjugate with an average yield of 68 ± 9%. In vitro stability tests indicated that the glutaraldehyde conjugated label was as stable as hEGF labeled with astatobenzoate. (author)

  6. 36 CFR 219.30 - Plan documentation.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Plan documentation. 219.30... National Forest System Land and Resource Management Planning Planning Documentation § 219.30 Plan documentation. A plan is a repository of documents that integrates and displays the desired...

  7. 48 CFR 219.808 - Contract negotiations.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract negotiations. 219..., DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (The 8(a) Program) 219.808 Contract negotiations....

  8. 48 CFR 219.708 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... OF DEFENSE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS The Small Business Subcontracting Program 219.708 Contract clauses. (b)(1)(A) Use the clause at 252.219-7003, Small Business Subcontracting Plan... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clauses....

  9. 48 CFR 219.1005 - Applicability.

    Science.gov (United States)

    2010-10-01

    ... Navigation System and Instrument Manufacturing 334511 (10) (i) Cellular and Other Wireless Telecommunications... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Applicability. 219.1005 Section 219.1005 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM,...

  10. 36 CFR 219.19 - Ecological, social, and economic sustainability.

    Science.gov (United States)

    2010-07-01

    ... economic sustainability. 219.19 Section 219.19 Parks, Forests, and Public Property FOREST SERVICE..., Social, and Economic Sustainability § 219.19 Ecological, social, and economic sustainability. Sustainability, composed of interdependent ecological, social, and economic elements, embodies the...

  11. Labelling prospects of astatine-211 with immunoglobulins (IgG): some general considerations

    International Nuclear Information System (INIS)

    The tumour therapeutic potential of the short lived alpha emitting radiohalogen 211At has been already been well recognised in the field of radioimmuno therapy. There is no evidence as such to show that astatine itself is a tumour seeking isotope. Therefore it has to be tagged to tumour seeking compound such as a drug or a protein preferably an antibody (IgG). In this communication, the labelling parameters which are required to be investigated for obtaining a stable product which could be useful as radioimmuno therapeutic agent, are described. (author). 6 refs

  12. Determination of the electron affinity of astatine and polonium by laser photodetachment

    CERN Multimedia

    We propose to conduct the first electron anity (EA) measurements of the two elements astatine (At) and polonium (Po). Collinear photodetachment spectroscopy will allow us to measure these quantities with an uncertainty limited only by the spectral linewidth of the laser. We plan to use negative ion beams of the two radioactive elements At and Po, which are only accessible on-line and at ISOLDE. The feasibility of our proposed method and the functionality of the experimental setup have been demonstrated at ISOLDE in o-line tests by the clear observation of the photodetachment threshold for stable iodine. This proposal is based on our Letter of Intent I-148 [1].

  13. Extraction of 211At-astatine from hydrochloric acid solutions by means of TOPO, TBP, and triphenylphosphine

    International Nuclear Information System (INIS)

    The extraction behaviour of astatine was studied under defined conditions from hydrochloride acid solutions (cHCl>0.1 M or 1 and 2M). Therefore other effects like adsorption, reduction or hydrolysis can be excluded. The present work describes the extraction with tri- n- octylphosphinoxide (TOPO), tri- n-butylphosphate (TBP) and tri-phenylphosphine in chloroform. (orig.)

  14. No-carrier-added astatination of N-succinimidyl-3-(tri-n-butylstannyl) benzoate (ATE) via electrophilic destannylation

    International Nuclear Information System (INIS)

    The no-carrier-added synthesis of N-succinimidyl 3-[211At]astato-benzoate from N-succinimidyl 3-(tri-n-butylstannyl)benzoate (ATE) is described. The nature of the solvent in which the 211At was isolated from the target was an important factor influencing both the radiochemical yields and the nature of the incorporated astatine activity. (orig.)

  15. 211At-Rh(16-S4-diol) complex as a precursor for astatine radiopharmaceuticals

    International Nuclear Information System (INIS)

    211At is one of the most promising radionuclides in α-radioimmunotherapy (α-RIT). Unfortunately, biomolecules labeled by direct electrophilic astatination are unstable due to the rapid loss of 211At under both in vitro and in vivo conditions. The present paper describes the results of our studies on attaching At- to the rhodium(III) complex with thioether ligand: 1,5,9,13-etrathiacyclohexadecane-3,11-diol (16-S4-diol). Rh3+ was chosen as a moderately soft metal cation which should form very strong bonds with soft At- anions, but first of all because of the kinetic inertness of low spin rhodium(III) d6 complexes. The 16-S4-diol ligand was selected due to formation of stable complexes with Rh3+. The experiments related to optimization of the reaction conditions were performed with the 131I, basing on a chemical similarity of I- to At-. The experiments with 211At were then carried out under the conditions found optimal for I-. The preliminary results are promising, and indicate a possibility for astatination of biomolecules by using the 211At-Rh(16-S4-diol) complex

  16. 36 CFR 219.7 - Plan decisions.

    Science.gov (United States)

    2010-07-01

    ...) Limitations on even-aged timber harvest methods; (2) Maximum size openings from timber harvest; (3) Methods... (§ 219.28). (e) Monitoring strategy. A monitoring strategy is required by each plan as described in §...

  17. 36 CFR 219.9 - Revision.

    Science.gov (United States)

    2010-07-01

    ...), and provide for an independent scientific peer review (§ 219.22) of the evaluation; (5) Identify new... conclusions from appropriate broad-scale assessments and local analyses, monitoring and evaluation...

  18. Dicty_cDB: CHR219 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CH (Link to library) CHR219 (Link to dictyBase) - - - Contig-U16511-1 CHR219P (Link to Original site) CHR...219F 609 CHR219Z 786 CHR219P 1375 - - Show CHR219 Library CH (Link to library) Clone ID CHR...e URL http://dictycdb.biol.tsukuba.ac.jp/CSM/CH/CHR2-A/CHR219Q.Seq.d/ Representative seq. ID CHR...219P (Link to Original site) Representative DNA sequence >CHR219 (CHR219Q) /CSM/CH/CHR2-A/CHR...ky**firs*ywswfkw**srrc*kprfirqircf*tsigsrrn*kprfgrscf*nhf*ir trsyssn*wsts*lyc*srnscss*inr*kcl*cllkhrtnittitt

  19. Radiological risk of actinon (219Rn)

    International Nuclear Information System (INIS)

    The research reported was designed to provide information on the following subjects: (1) development of the functional relations between exposure to the 219Rn decay chain and pertinent health effects; (2) specification of the circumstances under which a significant concentration of the decay chain may occur; (3) recommendation of an exposure standard which will provide protection of the public from significant elevation of health effects; and (4) an assessment of the impact of 219Rn on determinations of the concentration of the 222Rn decay chain and/or its precursors

  20. 36 CFR 219.18 - Role of advisory committees.

    Science.gov (United States)

    2010-07-01

    .... 219.18 Section 219.18 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE... members to the Secretary of Agriculture. Advisory committees used by other agencies may be utilized...)). Ecological, Social, and Economic Sustainability...

  1. 36 CFR 219.20 - Ecological sustainability.

    Science.gov (United States)

    2010-07-01

    ... under 50 CFR part 402. The plan decision documents must provide a rationale for adoption or rejection of... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Ecological sustainability... Sustainability § 219.20 Ecological sustainability. To achieve ecological sustainability, the responsible...

  2. 22 CFR 219.103 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... CFR 1613.702(f), which is made applicable to this part by § 219.140. Section 504 means section 504 of..., emotional or mental illness, and specific learning disabilities. The term “physical or mental impairment..., mental retardation, emotional illness, and drug addition and alcholism. (2) Major life...

  3. 49 CFR 199.219 - Pre-duty use.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Pre-duty use. 199.219 Section 199.219 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... Prevention Program § 199.219 Pre-duty use. Each operator shall prohibit a covered employee from using...

  4. 50 CFR 300.219 - Vessel monitoring system.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Vessel monitoring system. 300.219 Section 300.219 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Western and Central Pacific Fisheries for Highly Migratory Species § 300.219 Vessel monitoring system. (a) SAC and VMS Helpdesk...

  5. 20 CFR 219.23 - Evidence to prove death.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Evidence to prove death. 219.23 Section 219... EVIDENCE REQUIRED FOR PAYMENT Evidence of Age and Death § 219.23 Evidence to prove death. (a) Preferred evidence of death. The best evidence of a person's death is— (1) A certified copy of or extract from...

  6. 36 CFR 219.21 - Social and economic sustainability.

    Science.gov (United States)

    2010-07-01

    ... sustainability. 219.21 Section 219.21 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF... Economic Sustainability § 219.21 Social and economic sustainability. To contribute to economic and social sustainability, the responsible official involves interested and affected people in planning for National...

  7. 48 CFR 1353.219 - Small business programs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Small business programs. 1353.219 Section 1353.219 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE CLAUSES AND FORMS FORMS Prescription of Forms 1353.219 Small business programs. Use Form CD-570, Small Business...

  8. 48 CFR 653.219 - Small business programs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Small business programs. 653.219 Section 653.219 Federal Acquisition Regulations System DEPARTMENT OF STATE CLAUSES AND FORMS FORMS Prescription of Forms 653.219 Small business programs....

  9. 48 CFR 219.505 - Rejecting Small Business Administration recommendations.

    Science.gov (United States)

    2010-10-01

    ...-Asides for Small Business 219.505 Rejecting Small Business Administration recommendations. (b) The... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Rejecting Small Business Administration recommendations. 219.505 Section 219.505 Federal Acquisition Regulations System...

  10. Dicty_cDB: SHB219 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SH (Link to library) SHB219 (Link to dictyBase) - - - - SHB219P (Link to Original site) SHB219F ... sk*nvyryccnynifsinflcy*ntg*kiy*reksqksi*is**sts*ts*etc ... c*nr*tlfiwl*krsktk*klfl*frkeii*tpth*mlfqrty*lntisk ...

  11. 50 CFR 660.219 - Fixed gear identification and marking.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Fixed gear identification and marking. 660.219 Section 660.219 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... Groundfish-Limited Entry Fixed Gear Fisheries § 660.219 Fixed gear identification and marking. (a)...

  12. 48 CFR 219.705-4 - Reviewing the subcontracting plan.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Reviewing the subcontracting plan. 219.705-4 Section 219.705-4 Federal Acquisition Regulations System DEFENSE ACQUISITION... Subcontracting Program 219.705-4 Reviewing the subcontracting plan. (d) Challenge any subcontracting plan...

  13. 30 CFR 219.102 - Method of payment.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Method of payment. 219.102 Section 219.102... (EFT). Should a State prefer to receive its payment by EFT, it should request this payment method in... DISTRIBUTION AND DISBURSEMENT OF ROYALTIES, RENTALS, AND BONUSES Oil and Gas, Onshore § 219.102 Method...

  14. 48 CFR 219.811-3 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clauses. 219.811..., DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (The 8(a) Program) 219.811-3 Contract clauses. (1) Use the clause at 252.219-7009, Section...

  15. Unexpected Behavior of the Heaviest Halogen Astatine in the Nucleophilic Substitution of Aryliodonium Salts.

    Science.gov (United States)

    Guérard, François; Lee, Yong-Sok; Baidoo, Kwamena; Gestin, Jean-François; Brechbiel, Martin W

    2016-08-22

    Aryliodonium salts have become precursors of choice for the synthesis of (18) F-labeled tracers for nuclear imaging. However, little is known on the reactivity of these compounds with heavy halides, that is, radioiodide and astatide, at the radiotracer scale. In the first comparative study of radiohalogenation of aryliodonium salts with (125) I(-) and (211) At(-) , initial experiments on a model compound highlight the higher reactivity of astatide compared to iodide, which could not be anticipated from the trends previously observed within the halogen series. Kinetic studies indicate a significant difference in activation energy (Ea =23.5 and 17.1 kcal mol(-1) with (125) I(-) and (211) At(-) , respectively). Quantum chemical calculations suggest that astatination occurs via the monomeric form of an iodonium complex whereas iodination occurs via a heterodimeric iodonium intermediate. The good to excellent regioselectivity of halogenation and high yields achieved with diversely substituted aryliodonium salts indicate that this class of compounds is a promising alternative to the stannane chemistry currently used for heavy radiohalogen labeling of tracers in nuclear medicine. PMID:27305065

  16. Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

    CERN Document Server

    Andreyev, Andrei

    2013-01-01

    Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

  17. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

    Energy Technology Data Exchange (ETDEWEB)

    MICHAEL R. ZALUTSKY

    2012-08-08

    Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

  18. Dicty_cDB: AFM219 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available AF (Link to library) AFM219 (Link to dictyBase) - - - - - (Link to Original site) AFM219F 627 - ... v*vvvm lqeivmmvihvqlisvqsqpavfdl--- Frame B: fr**f*csr *kq*w*klsiryysynefr**iklfl**srifpn*wkri*crstip*ll** ... sktis*lsllcqnyq*sfhiqrf*ni*irr***clgih**kvgcrfgwftycsr e ny*sy*twscc**tlcn*flll*ktyfkinnsy*nnn*tsmsmv*flwc ...

  19. 20 CFR 219.24 - Evidence of presumed death.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Evidence of presumed death. 219.24 Section... EVIDENCE REQUIRED FOR PAYMENT Evidence of Age and Death § 219.24 Evidence of presumed death. When a person cannot be proven dead but evidence of death is needed, the Board may presume he or she died at a...

  20. 14 CFR 21.9 - Replacement and modification articles.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Replacement and modification articles. 21.9... CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS General § 21.9 Replacement and modification articles. (a) If a person knows, or should know, that a replacement or modification article is reasonably likely to...

  1. 48 CFR 1852.219-73 - Small business subcontracting plan.

    Science.gov (United States)

    2010-10-01

    ... Provisions and Clauses 1852.219-73 Small business subcontracting plan. As prescribed in 1819.708-70(a), insert the following provision: Small Business Subcontracting Plan (MAY 1999) (a) This provision is not... contain FAR clause 52.219-9, “Small Business Subcontracting Plan.” The apparent low bidder must submit...

  2. 49 CFR 219.211 - Analysis and follow-up.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Analysis and follow-up. 219.211 Section 219.211 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Analysis and follow-up. (a) The laboratory designated in appendix B to this part undertakes prompt...

  3. Dicty_cDB: CFF219 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CF (Link to library) CFF219 (Link to dictyBase) - - - Contig-U14176-1 CFF219Z (Link to Original ... lpi**k qpkkivqfhqs*ikfqvlvlll Frame C: ---rrhck*xt*car **kk*xlcccinycsrl*cwtrrch*stss**rtyxfixt*sws* scqsk ...

  4. 49 CFR 219.105 - Railroad's duty to prevent violations.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Railroad's duty to prevent violations. 219.105 Section 219.105 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD... duty to prevent violations. (a) A railroad may not, with actual knowledge, permit an employee to go...

  5. An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE, CERN

    CERN Document Server

    Rothe, Sebastian; Nörtershäuser, W

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at ISOLDE, CERN, by the addition of an all-solid state tuneable titanium: sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE, CERN, and at ISAC, TRIUMF, radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  6. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    Energy Technology Data Exchange (ETDEWEB)

    Rothe, Sebastian

    2012-09-24

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  7. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    International Nuclear Information System (INIS)

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  8. 49 CFR 219.302 - Prompt specimen collection; time limitation.

    Science.gov (United States)

    2010-10-01

    ... or drug testing under this section after the expiration of an eight-hour period from— (1) The time of... period. (f) (g) Section 219.23 prescribes the notice to an employee that is required to provide breath...

  9. Dicty_cDB: SLF219 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLF219 (Link to dictyBase) - - - Contig-U15420-1 SLF219Z (Link to Original ... ime mold (D.discoideum) transposable element Tdd-1 right ... terminal repeat and flanks. 293 e-158 5 M11340 |M1 ... K03070 |K03070.1 Slime mold (D.discoideum) DIRS-1 right ... inverted terminal repeat, clone CP19-1. 226 e-119 ...

  10. Stability and in vivo behavior of Rh[16aneS4-diol]211At complex: A potential precursor for astatine radiopharmaceuticals

    International Nuclear Information System (INIS)

    Introduction: The heavy halogen 211At is of great interest for targeted radiotherapy because it decays by the emission of short-range, high-energy α-particles. However, many astatine compounds that have been synthesized are unstable in vivo, providing motivation for seeking other 211At labeling strategies. One relatively unexplored approach is to utilize prosthetic groups based on astatinated rhodium (III) complex stabilized with a tetrathioether macrocyclic ligand – Rh[16aneS4-diol]211At. The purpose of the current study was to evaluate the in vitro and in vivo stability of this complex in comparison to its iodine analog – Rh[16aneS4-diol]131I. Methods: Rh[16aneS4-diol]211At and Rh[16aneS4-diol]131I complexes were synthesized and purified by HPLC. The stability of both complexes was evaluated in vitro by incubation in phosphate-buffered saline (PBS) and human serum at different temperatures. The in vivo behavior of the two radiohalogenated complexes was assessed by a paired-label biodistribution study in normal Balb/c mice. Results: Both complexes were synthesized in high yield and purity. Almost no degradation was observed for Rh[16aneS4-diol]131I in PBS over a 72 h incubation. The astatinated analog exhibited good stability in PBS over 14 h. A slow decline in the percentage of intact complex was observed for both tracers in human serum. In the biodistribution study, retention of 211At in most tissues was higher than that of 131I at all time points, especially in spleen and lungs. Renal clearance of Rh[16aneS4-diol]211At and Rh[16aneS4-diol]131I predominated, with 84.1 ± 2.3% and 94.6 ± 0.9% of injected dose excreted via the urine at 4 h. Conclusions: The Rh[16aneS4-diol]211At complex might be useful for constructing prosthetic groups for the astatination of biomolecules and further studies are planned to evaluate this possibility

  11. 48 CFR 52.219-10 - Incentive Subcontracting Program.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Incentive Subcontracting....219-10 Incentive Subcontracting Program. As prescribed in 19.708(c)(1), insert the following clause: Incentive Subcontracting Program (OCT 2001) (a) Of the total dollars it plans to spend under...

  12. 36 CFR 219.5 - Information development and interpretation.

    Science.gov (United States)

    2010-07-01

    ... PLANNING National Forest System Land and Resource Management Planning The Framework for Planning § 219.5...) Station Directors and Regional Foresters must have joint responsibility for Forest Service participation... assessments provide information regarding ecological, economic, or social issues that are broad in...

  13. 36 CFR 219.29 - Limitation on timber harvest.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Limitation on timber harvest... Limitation on timber harvest. (a) Estimate of the limitation of timber harvest. The responsible official must... for lands identified in § 219.28(c) cannot be combined. (b) Limitation of timber harvest....

  14. 26 CFR 1.219-1 - Deduction for retirement savings.

    Science.gov (United States)

    2010-04-01

    ..., the cost of current life insurance protection under an endowment contract described in paragraph (b)(3...'s age is $1.61 per thousand dollars of life insurance protection. The cost of current life insurance... current life insurance protection is $16.37 ($1.67 × 9.8). A's maximum deduction under section 219...

  15. 48 CFR 53.219 - Small Business Programs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Small Business Programs... (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.219 Small Business Programs. (a) The following form may be used in reporting small disadvantaged business contracting data: OF 312 (10/00),...

  16. 12 CFR 219.21 - Authority, purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... Authority, purpose and scope. This subpart of Regulation S (12 CFR part 219, subpart B) is issued by the... amended by the Annunzio-Wylie Anti-Money Laundering Act of 1992 (Pub. L. 102-550, Title XV; 106 Stat. 3672... promulgated and administered jointly by the Board and the Treasury and are codified in 31 CFR 103.11 and...

  17. Morphological differentiation of Streptomyces viridochromogenes E-219 on solid culture

    International Nuclear Information System (INIS)

    The Streptomyces viridochromogenes E-219 was derived from Streptomyces viridochromogenes CGMCC4.1119 treated with 60Co γ-rays irradiation and protoplast fusion. With the help of fluorescent probes, fluorescence microscope and electron microscopy, the morphology and development of E-219 on solid surface culture were investigated in this study. The effect of agarslant culture time on the production of Avilamycin was also studied to provide theoretical basis for industrial fermentation of selecting the appropriate seed to culture on the agarslant culture medium. The results implied that the development of colonies of Streptomyces viridochromogenes accompanied the intermittent hyhae apoptosis, and the production of spores was from the active mycelium. The colonial morphology of strain E-219 was significantly different from the original strain CGMCC4h1119. There were variegated hyphae formation in the stage of spore germination and initial hyphae development (10 h) with the live and dead segments alternated in a highly regular fashion within the same hypha. After the early single colony formation, the third phase was followed by profuse growth of the live segments derived from the variegated hypha, then the second apoptosis of the mycelia (48 h) was occurred with another quick growth, and sporulation was occurred at 96 h. Strain CGMCC4.1119 had spiral sporotrichial and round conidiophores with spike, whereas strain E-219 had linear sporotrichial, smooth and dylindrical conidiophore. The results of shake flask experiments indicated that the spores of E-219 had that highest activity when cultured on agarslant culture medium and incubated for 106 h with the production of avilamycin up to 1200 mg/L. (authors)

  18. 76 FR 50810 - Seventh Meeting: RTCA Special Committee 219: Attitude and Heading Reference System

    Science.gov (United States)

    2011-08-16

    ... Federal Aviation Administration Seventh Meeting: RTCA Special Committee 219: Attitude and Heading... Committee 219 meeting: Attitude and Heading Reference System. SUMMARY: The FAA is issuing this notice to advise the public of a meeting of RTCA Special Committee 219: Attitude and Heading Reference...

  19. 36 CFR 219.12 - Collaboration and cooperatively developed landscape goals.

    Science.gov (United States)

    2010-07-01

    ... cooperatively developed landscape goals. 219.12 Section 219.12 Parks, Forests, and Public Property FOREST... Collaborative Planning for Sustainability § 219.12 Collaboration and cooperatively developed landscape goals. (a... process. (b) Cooperatively developed landscape goals. (1) The responsible official and other...

  20. 48 CFR 1852.219-83 - Limitation of the principal investigator-SBIR program.

    Science.gov (United States)

    2010-10-01

    ... investigator-SBIR program. 1852.219-83 Section 1852.219-83 Federal Acquisition Regulations System NATIONAL... Provisions and Clauses 1852.219-83 Limitation of the principal investigator—SBIR program. As prescribed in 1819.7302(d), insert the following clause: Limitation of the Principal Investigator—SBIR Program...

  1. 48 CFR 1852.219-84 - Limitation of the principal investigator-STTR program.

    Science.gov (United States)

    2010-10-01

    ... investigator-STTR program. 1852.219-84 Section 1852.219-84 Federal Acquisition Regulations System NATIONAL... Provisions and Clauses 1852.219-84 Limitation of the principal investigator—STTR program. As prescribed in 1819.7302(e), insert the following clause: Limitation of the Principal Investigator—STTR Program...

  2. 26 CFR 2.1-9 - Valuation of securities in fund.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 14 2010-04-01 2010-04-01 false Valuation of securities in fund. 2.1-9 Section 2.1-9 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) MARITIME CONSTRUCTION RESERVE FUND § 2.1-9 Valuation of securities in fund. (a) Equivalent...

  3. 36 CFR 219.28 - Determination of land suitable for timber harvest.

    Science.gov (United States)

    2010-07-01

    ... suitable for timber harvest. 219.28 Section 219.28 Parks, Forests, and Public Property FOREST SERVICE... Considerations § 219.28 Determination of land suitable for timber harvest. (a) Lands where timber may not be... include: (1) Lands where timber harvest would violate statute, Executive Order, or regulation and...

  4. 40 CFR 80.219 - Designation and downstream requirements for GPA gasoline.

    Science.gov (United States)

    2010-07-01

    ... requirements for GPA gasoline. 80.219 Section 80.219 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY...-in Program § 80.219 Designation and downstream requirements for GPA gasoline. The requirements and... standards under § 80.216 as “GPA” gasoline. (b) Product transfer documents. (1) On each occasion that...

  5. Mass determination of K2-19b and K2-19c from radial velocities and transit timing variations

    CERN Document Server

    Nespral, D; Deeg, H J; Borsato, L; Fridlund, M C V; Barragan, O; Grziwa, S; Korth, J; Cabrera, J; Csizmadia, Sz; Nowak, G; Kuutma, T; Saario, J; Eigmuller, P; Erikson, A; Guenther, E W; Hatzes, A P; Rodriguez, P Montanes; Palle, E; Patzold, M; Prieto-Arranz, J; Rauer, H; Sebastian, D

    2016-01-01

    We present FIES@NOT and HARPS-N@TNG radial velocity follow-up observations of K2-19, a compact planetary system hosting three planets, of which the two larger ones, namely K2-19b and K2-19c, are close to the 3:2 mean motion resonance. The masses of these larger planets have previously been derived from transit timing only. An analysis considering only the radial velocity measurements is able to detect only K2-19b, the largest and more massive planet in the system, with a mass of $71.7\\pm6.3$ M${_\\oplus}$. We also used the TRADES code to simultaneously model both our RV measurements and the existing transit-timing measurements. We derived a mass of K2-19b of $59.5^{+7.2}_{-11.4}$ M${_\\oplus}$ and of K2-19c of $9.7^{+3.9}_{-2.0}$ M${_\\oplus}$. A prior K2-19b mass estimated by Barros 2015, based exclusively on transit timing measurements, is only consistent with our combined TTV and RV analysis, but not with our analysis based purely on RV measurements. K2-19b supports the suspicion that planet masses and densit...

  6. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D., Scott

    2011-12-14

    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  7. Establishment of radioactive astatine and iodine uptake in cancer cell lines expressing the human sodium/iodide symporter

    International Nuclear Information System (INIS)

    The sodium/iodide symporter (NIS) has been recognized as an attractive target for radioiodine-mediated cancer gene therapy. In this study we investigated the role of human NIS for cellular uptake of the high LET α-emitter astatine-211 (211At) in comparison with radioiodine as a potential radionuclide for future applications. A mammalian NIS expression vector was constructed and used to generate six stable NIS-expressing cancer cell lines (three derived from thyroid carcinoma, two from colon carcinoma, one from glioblastoma). Compared with the respective control cell lines, steady state radionuclide uptake of NIS-expressing cell lines increased up to 350-fold for iodine-123 (123I), 340-fold for technetium-99m pertechnetate (99mTcO4-) and 60-fold for 211At. Cellular 211At accumulation was found to be dependent on extracellular Na+ ions and displayed a similar sensitivity towards sodium perchlorate inhibition as radioiodide and 99mTcO4- uptake. Heterologous competition with unlabelled NaI decreased NIS-mediated 211At uptake to levels of NIS-negative control cells. Following uptake both radioiodide and 211At were rapidly (apparent t1/2 3-15 min) released by the cells as determined by wash-out experiments. Data of scintigraphic tumour imaging in a xenograft nude mice model of transplanted NIS-modified thyroid cells indicated that radionuclide uptake in NIS-expressing tumours was up to 70 times (123I), 25 times (99mTcO4-) and 10 times (211At) higher than in control tumours or normal tissues except stomach (3-5 times) and thyroid gland (5-10 times). Thirty-four percent and 14% of the administered activity of 123I and 211At, respectively, was found in NIS tumours by region of interest analysis (n=2). Compared with cell culture experiments, the effective half-life in vivo was greatly prolonged (6.5 h for 123I, 5.2 h for 211At) and preliminary dosimetric calculations indicate high tumour absorbed doses (3.5 Gy/MBqtumour for 131I and 50.3 Gy/MBqtumour for 211At). In

  8. Evaluation of Nitrogen Uptake and Growth Performance of Advanced Mutant Lines MR219-4 and MR219-9 Grown Under Aerobic Conditions

    International Nuclear Information System (INIS)

    Developing a good crop production management package; drought resistance variety, effective water and nutrient management in rice production practices is crucial for global climate change adaptation. A research project under IAEA RAS5065 (Supporting Climate-Proofing Rice Production Systems (CRiPS) Based on Nuclear Applications) was conducted from 2012 to 2013, in collaboration with MARDI. Two advanced mutant lines, MR219-4 and MR219-9 were used in this research project to evaluate growth, yield potential and fertilizer uptake under different water input condition (flooded and aerobic). The advanced mutant line MR219-9 showed comparable growth, yield and nitrogen uptake under both flooded and aerobic conditions. The yield and yield components are not significantly different from the parent variety (MR219) but total N uptake was lower than MR219 regardless of water regime. The field trial showed that MR219-9 has a better total N content which is comparable to the aerobic rice variety (MRIA 1) and this indicates that this advance mutant line MR219-9 is a potential aerobic rice variety. (author)

  9. Establishment of radioactive astatine and iodine uptake in cancer cell lines expressing the human sodium/iodide symporter

    Energy Technology Data Exchange (ETDEWEB)

    Petrich, T.; Helmeke, H.-J.; Meyer, G.J.; Knapp, W.H.; Poetter, E. [Department of Nuclear Medicine, Medizinische Hochschule Hannover (Germany)

    2002-07-01

    The sodium/iodide symporter (NIS) has been recognized as an attractive target for radioiodine-mediated cancer gene therapy. In this study we investigated the role of human NIS for cellular uptake of the high LET {alpha}-emitter astatine-211 ({sup 211}At) in comparison with radioiodine as a potential radionuclide for future applications. A mammalian NIS expression vector was constructed and used to generate six stable NIS-expressing cancer cell lines (three derived from thyroid carcinoma, two from colon carcinoma, one from glioblastoma). Compared with the respective control cell lines, steady state radionuclide uptake of NIS-expressing cell lines increased up to 350-fold for iodine-123 ({sup 123}I), 340-fold for technetium-99m pertechnetate ({sup 99m}TcO{sub 4}{sup -}) and 60-fold for {sup 211}At. Cellular {sup 211}At accumulation was found to be dependent on extracellular Na{sup +} ions and displayed a similar sensitivity towards sodium perchlorate inhibition as radioiodide and {sup 99m}TcO{sub 4}{sup -} uptake. Heterologous competition with unlabelled NaI decreased NIS-mediated {sup 211}At uptake to levels of NIS-negative control cells. Following uptake both radioiodide and {sup 211}At were rapidly (apparent t{sub 1/2} 3-15 min) released by the cells as determined by wash-out experiments. Data of scintigraphic tumour imaging in a xenograft nude mice model of transplanted NIS-modified thyroid cells indicated that radionuclide uptake in NIS-expressing tumours was up to 70 times ({sup 123}I), 25 times ({sup 99m}TcO{sub 4}{sup -}) and 10 times ({sup 211}At) higher than in control tumours or normal tissues except stomach (3-5 times) and thyroid gland (5-10 times). Thirty-four percent and 14% of the administered activity of {sup 123}I and {sup 211}At, respectively, was found in NIS tumours by region of interest analysis (n=2). Compared with cell culture experiments, the effective half-life in vivo was greatly prolonged (6.5 h for {sup 123}I, 5.2 h for {sup 211}At) and

  10. 20 CFR 219.40 - Evidence of relationship by equitable adoption-child.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Evidence of relationship by equitable adoption-child. 219.40 Section 219.40 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE... relationship by equitable adoption—child. (a) Preferred evidence. If the claimant is a person who claims to...

  11. 20 CFR 219.35 - Evidence that a marriage has ended.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Evidence that a marriage has ended. 219.35... EVIDENCE REQUIRED FOR PAYMENT Evidence of Relationship § 219.35 Evidence that a marriage has ended. (a) Preferred evidence. Preferred evidence that a marriage has ended is— (1) A certified copy of the decree...

  12. 20 CFR 219.32 - Evidence of a common-law marriage.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Evidence of a common-law marriage. 219.32... EVIDENCE REQUIRED FOR PAYMENT Evidence of Relationship § 219.32 Evidence of a common-law marriage. (a) Preferred evidence. Evidence of a common-law marriage must give the reasons why the informant believes...

  13. 20 CFR 219.33 - Evidence of a deemed valid marriage.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Evidence of a deemed valid marriage. 219.33... EVIDENCE REQUIRED FOR PAYMENT Evidence of Relationship § 219.33 Evidence of a deemed valid marriage. (a) Preferred evidence. Preferred evidence of a deemed valid marriage is— (1) Evidence of a ceremonial...

  14. 20 CFR 219.30 - When evidence of marriage is required.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false When evidence of marriage is required. 219.30... EVIDENCE REQUIRED FOR PAYMENT Evidence of Relationship § 219.30 When evidence of marriage is required. (a) When an application is filed for benefits. Documentary evidence of marriage is required when...

  15. 49 CFR 234.219 - Gate arm lights and light cable.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Gate arm lights and light cable. 234.219 Section... Maintenance, Inspection, and Testing Maintenance Standards § 234.219 Gate arm lights and light cable. Each gate arm light shall be maintained in such condition to be properly visible to approaching...

  16. 48 CFR 52.219-4 - Notice of price evaluation preference for HUBZone small business concerns.

    Science.gov (United States)

    2010-10-01

    ... successful offers from small business concerns. (2) The factor of 10 percent shall be applied on a line item... preference for HUBZone small business concerns. 52.219-4 Section 52.219-4 Federal Acquisition Regulations... business concerns. As prescribed in 19.1308(b), insert the following clause: Notice of Price...

  17. 48 CFR 52.219-7 - Notice of Partial Small Business Set-Aside.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Notice of Partial Small Business Set-Aside. 52.219-7 Section 52.219-7 Federal Acquisition Regulations System FEDERAL ACQUISITION... Federal Prison Industries, Inc., will be solicited and considered for both the set-aside and...

  18. 48 CFR 2452.219-70 - Small business subcontracting plan compliance.

    Science.gov (United States)

    2010-10-01

    ... of Provisions and Clauses 2452.219-70 Small business subcontracting plan compliance. As prescribed in 2419.708(d), insert the following provision: Small Business Subcontracting Plan Compliance (FEB 2006... the clause at FAR 52.219-9, Small Business Subcontracting Plan. (c) The government will...

  19. 14 CFR 91.219 - Altitude alerting system or device: Turbojet-powered civil airplanes.

    Science.gov (United States)

    2010-01-01

    ...: Turbojet-powered civil airplanes. 91.219 Section 91.219 Aeronautics and Space FEDERAL AVIATION... system or device: Turbojet-powered civil airplanes. (a) Except as provided in paragraph (d) of this section, no person may operate a turbojet-powered U.S.-registered civil airplane unless that airplane...

  20. 49 CFR Appendix C to Part 219 - Post-Accident Testing Specimen Collection

    Science.gov (United States)

    2010-10-01

    ... of specimen or dissipation of volatiles (ethyl alcohol). Note: If only cavity fluid is available... RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Pt. 219, App. C... Toxicological Testing (49 CFR part 219), describing the testing event and identifying the employees...

  1. Evaluation and characterization of advanced rice mutant line of rice (Oryza sativa), MR219-4 and MR219-9 under drought condition

    International Nuclear Information System (INIS)

    Two advance rice mutant lines, MR219-4 and MR219-9 derived from mutagenesis of Oryza sativa cv. MR219 with gamma radiation at 300 Gy were evaluated in simulated drought condition in the greenhouse at Malaysian Nuclear Agency. The mutants were evaluated simultaneously with ARN1, a drought resistant variety and MR211 a susceptible cultivar as a check. Randomized complete block design with three replicates was used in the experiment. The evaluation and selection were done based on leaf rolling and leaf drying as well as other agronomic traits, such as, number of tillers per plant, plant height, flag leaf area, grain weight per plant, grain yield per plant, 100-grain weight, harvest index, panicle length and plant biomass. The mutants MR219-4 showed moderate tolerance and MR219-9 showed tolerance to drought respectively as compare to the check variety (ARN1, MR211) and control MR219. Leaf rolling, leaf drying, days to flowering and days to maturity are valuable secondary traits that may provide additional information for selection because of associating with the plant survival under water stress. Further research on expression of drought-tolerant lines under different drought conditions is essential in order to identify particular traits that are associated with drought tolerance and high yield potential. Similarly the importance of secondary traits, relative to other putative traits for drought tolerance, needs to be tested in various environments. (author)

  2. 47 CFR 80.219 - Special requirements for narrow-band direct-printing (NB-DP) equipment.

    Science.gov (United States)

    2010-10-01

    ... reference in accordance with 5 U.S.C. 552(a) and 1 CFR part 51. Copies of these standards can be inspected...-printing (NB-DP) equipment. 80.219 Section 80.219 Telecommunication FEDERAL COMMUNICATIONS COMMISSION... § 80.219 Special requirements for narrow-band direct-printing (NB-DP) equipment. NB-DP and...

  3. 18 CFR 367.2190 - Account 219, Accumulated other comprehensive income.

    Science.gov (United States)

    2010-04-01

    ... POWER ACT AND NATURAL GAS ACT Balance Sheet Chart of Accounts Proprietary Capital § 367.2190 Account 219... COMPANY ACT OF 2005, FEDERAL POWER ACT AND NATURAL GAS ACT UNIFORM SYSTEM OF ACCOUNTS FOR...

  4. Durable donor engraftment after radioimmunotherapy using α-emitter astatine-211-labeled anti-CD45 antibody for conditioning in allogeneic hematopoietic cell transplantation.

    Science.gov (United States)

    Chen, Yun; Kornblit, Brian; Hamlin, Donald K; Sale, George E; Santos, Erlinda B; Wilbur, D Scott; Storer, Barry E; Storb, Rainer; Sandmaier, Brenda M

    2012-02-01

    To reduce toxicity associated with external γ-beam radiation, we investigated radioimmunotherapy with an anti-CD45 mAb labeled with the α-emitter, astatine-211 ((211)At), as a conditioning regimen in dog leukocyte antigen-identical hematopoietic cell transplantation (HCT). Dose-finding studies in 6 dogs treated with 100 to 618 μCi/kg (211)At-labeled anti-CD45 mAb (0.5 mg/kg) without HCT rescue demonstrated dose-dependent myelosuppression with subsequent autologous recovery, and transient liver toxicity in dogs treated with (211)At doses less than or equal to 405 μCi/kg. Higher doses of (211)At induced clinical liver failure. Subsequently, 8 dogs were conditioned with 155 to 625 μCi/kg (211)At-labeled anti-CD45 mAb (0.5 mg/kg) before HCT with dog leukocyte antigen-identical bone marrow followed by a short course of cyclosporine and mycophenolate mofetil immunosuppression. Neutropenia (1-146 cells/μL), lymphopenia (0-270 cells/μL), and thrombocytopenia (1500-6560 platelets/μL) with prompt recovery was observed. Seven dogs had long-term donor mononuclear cell chimerism (19%-58%), whereas 1 dog treated with the lowest (211)At dose (155 μCi/kg) had low donor mononuclear cell chimerism (5%). At the end of follow-up (18-53 weeks), only transient liver toxicity and no renal toxicity had been observed. In conclusion, conditioning with (211)At-labeled anti-CD45 mAb is safe and efficacious and provides a platform for future clinical trials of nonmyeloablative transplantation with radioimmunotherapy-based conditioning. PMID:22134165

  5. A Novel Zinc Finger Protein 219-like (ZNF219L) is Involved in the Regulation of Collagen Type 2 Alpha 1a (col2a1a) Gene Expression in Zebrafish Notochord

    OpenAIRE

    Lien, Huang-Wei; Yang, Chung-Hsiang; Cheng, Chia-Hsiung; Hung, Chin-Chun; Liao, Wei-Hao; Hwang, Pung-Pung; Han, Yu-San; Huang, Chang-Jen

    2013-01-01

    The notochord is required for body plan patterning in vertebrates, and defects in notochord development during embryogenesis can lead to diseases affecting the adult. It is therefore important to elucidate the gene regulatory mechanism underlying notochord formation. In this study, we cloned the zebrafish zinc finger 219-like (ZNF219L) based on mammalian ZNF219, which contains nine C2H2-type zinc finger domains. Through whole-mount in situ hybridization, we found that znf219L mRNA is mainly e...

  6. MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction

    DEFF Research Database (Denmark)

    Kocerha, Jannet; Faghihi, Mohammad Ali; Lopez-Toledano, Miguel A;

    2009-01-01

    significantly modulated behavioral responses associated with disrupted NMDA receptor transmission. Furthermore, pretreatment with the antipsychotic drugs haloperidol and clozapine prevented dizocilpine-induced effects on miR-219. Taken together, these data support an integral role for miR-219 in the expression......N-methyl-D-aspartate (NMDA) glutamate receptors are regulators of fast neurotransmission and synaptic plasticity in the brain. Disruption of NMDA-mediated glutamate signaling has been linked to behavioral deficits displayed in psychiatric disorders such as schizophrenia. Recently, noncoding RNA...... of behavioral aberrations associated with NMDA receptor hypofunction....

  7. 75 FR 25844 - Class Deviation From FAR 52.219-7, Notice of Partial Small Business Set-Aside

    Science.gov (United States)

    2010-05-10

    ... of the Secretary Class Deviation From FAR 52.219-7, Notice of Partial Small Business Set-Aside AGENCY... class deviation to the Federal Acquisition Regulation (FAR) regarding partial small business set-asides... Clause 52.219-7, Notice of Partial Small Business Set-Aside. DESC intends to use the clause in...

  8. 7 CFR 1726.405 - Inventory of work orders (RUS Form 219).

    Science.gov (United States)

    2010-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Contract Closeout § 1726.405 Inventory of work orders (RUS Form 219). Upon completion of the contract closeout, the... Policies and Procedures Common to Insured and Guaranteed Electric Loans, of this chapter....

  9. 36 CFR 223.219 - Sustainable harvest of special forest products.

    Science.gov (United States)

    2010-07-01

    ....219 Sustainable harvest of special forest products. (a) Sustainable harvest levels. Prior to offering... product's sustainable harvest level. A special forest product's sustainable harvest level is the total... forest officers may consult with other appropriate parties to determine sustainable harvest levels...

  10. 48 CFR 52.219-8 - Utilization of small business concerns.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Utilization of small... Clauses 52.219-8 Utilization of small business concerns. As prescribed in 19.708(a), insert the following clause: Utilization of Small Business Concerns (MAY 2004) (a) It is the policy of the United States...

  11. 48 CFR 752.219-8 - Utilization of small business concerns and small disadvantaged business concerns.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Utilization of small... AND CONTRACT CLAUSES Texts of Provisions and Clauses 752.219-8 Utilization of small business concerns..., provide the following information to the Office of Small and Disadvantaged Business Utilization...

  12. 20 CFR 219.31 - Evidence of a valid ceremonial marriage.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Evidence of a valid ceremonial marriage. 219... marriage. (a) Preferred evidence. Preferred evidence of a ceremonial marriage is— (1) A copy of the public record of the marriage, certified by the custodian of the record or by a Board employee; (2) A copy of...

  13. 27 CFR 28.219 - Return of wine withdrawn for export with benefit of drawback.

    Science.gov (United States)

    2010-04-01

    ... zone, may for good cause be returned under the applicable provisions of this part and 27 CFR part 24... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Return of wine withdrawn... Exportation of Wine With Benefit of Drawback § 28.219 Return of wine withdrawn for export with benefit...

  14. Evaluation of 3 Inch SN-219 Failure and S and SX Tank Farm Saltwell Piping

    International Nuclear Information System (INIS)

    Evaluation of direct buried piping currently in use or designated for future Saltwell pumping in S and SX Farms. Documented evaluation of failed S-103 saltwell pumping transfer line 3 inch SN-219. This evaluation is intended to reflect current status of Saltwell piping, when taken in context with referenced documents

  15. Sfragís and its metaphorical testimonial presence in 2 Timothy 2:19

    Directory of Open Access Journals (Sweden)

    Carlos Molina

    2011-03-01

    Full Text Available This article presented a metaphorical testimonial approach in the interpretation of 2 Timothy 2:19 and the use of sealing. As starting point, attention was given to the concept of ‘seal’ through the Old Testament and Ancient Near East. These periods attest the fact that sealing was also utilised in a figurative way as a sign of ownership, property and authenticity. Sfragís in 2 Timothy 2:19 describes the intimate relationship between Christ and his followers through the terms [foreign font omitted (personal and vital relationship that transcends in practice and [foreign font omitted (mainly an exterior knowledge]. These two vocables are in opposition to [foreign font omitted (to apostate from]. The message expressed in 2:19 exemplifies the principles that Christ lived by and he empowered his followers to stand by. Sfragís in 2 Timothy 2:19 is an imitatio Christi response against the [foreign font omitted] of moral standards and entertainment in the ancient Roman world. It includes a rapid contemporary reflection on practical faithfulness for today’s life. 

  16. 48 CFR 852.219-9 - VA Small business subcontracting plan minimum requirements.

    Science.gov (United States)

    2010-10-01

    ... Provisions and Clauses 852.219-9 VA Small business subcontracting plan minimum requirements. As prescribed in subpart 819.709, insert the following clause: VA Small Business Subcontracting Plan Minimum Requirements... plan, the minimum goals for award of subcontracts to service-disabled veteran-owned small...

  17. 25 CFR 2.19 - Action by Area Directors and Education Programs officials on appeal.

    Science.gov (United States)

    2010-04-01

    ...—Indian Affairs/Director (Indian Education Programs) shall render written decisions in all cases appealed... 25 Indians 1 2010-04-01 2010-04-01 false Action by Area Directors and Education Programs officials... AND PRACTICE APPEALS FROM ADMINISTRATIVE ACTIONS § 2.19 Action by Area Directors and...

  18. 48 CFR 252.219-7003 - Small business subcontracting plan (DoD contracts).

    Science.gov (United States)

    2010-10-01

    ... AND CONTRACT CLAUSES Text of Provisions And Clauses 252.219-7003 Small business subcontracting plan...-9, Small Business Subcontracting Plan, clause of this contract. (a) Definitions. Historically black... Education to meet the requirements of 34 CFR 608.2. The term also means any nonprofit research...

  19. 49 CFR 219.608 - FRA Administrator's determination of random alcohol testing rate.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false FRA Administrator's determination of random... Random Alcohol and Drug Testing Programs § 219.608 FRA Administrator's determination of random alcohol... percentage rate for random alcohol testing must be 25 percent of covered employees. (b) The...

  20. 49 CFR 219.602 - FRA Administrator's determination of random drug testing rate.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false FRA Administrator's determination of random drug... Random Alcohol and Drug Testing Programs § 219.602 FRA Administrator's determination of random drug... percentage rate for random drug testing must be 50 percent of covered employees. (b) The FRA...

  1. MicroRNA-219-5p Inhibits Morphine-Induced Apoptosis by Targeting Key Cell Cycle Regulator WEE1.

    Science.gov (United States)

    Lou, Wei; Zhang, Xingwang; Hu, Xiao-Ying; Hu, Ai-Rong

    2016-01-01

    BACKGROUND To identify the effects of microRNA (miR)-219-5p on morphine-induced apoptosis by targeting WEE1. MATERIAL AND METHODS Forty Balb/C mice (Toll-like receptor 9, TLR9 knockout) were randomly allocated to the experimental and control groups (20 in each group). The baseline miR-219-5p expression was detected using quantitative real-time PCR (qRT-PCR). After morphine was injected at 6 h on the 2nd and 6th days, experimental and control groups received miR-219-5p mimics or miRNA-negative control (NC), respectively, compound injection. Tissues and cells were later obtained from subjects in each group separately after mice were killed. TUNEL assay was used to investigate apoptosis in both groups. RAW264.7 cells were treated with miR-219-5p mimics and controls, respectively. After 24 h, 10 μM of morphine was added at 24 h. Cell apoptosis was assessed by flow cytometer. The WEE1 and Phospho-cdc2 (Tyr15) expressions were examined by Western blotting. RESULTS MiR-219-5p expression in the experimental group was significantly lower than that in the control group (P<0.05). Mice injected with miR-219-5p mimic experienced an evident increase in apoptosis rate compared with the control group (P<0.05). The miR-219-5p NC group and the morphine group both presented an elevated apoptosis rate compared with the blank control group (both, P<0.05). The apoptosis rate in the miR-219-5p mimic group was 10.06%, remarkably lower than in the miR-219-5p NC group and blank control group (both P<0.05). WEE1 and Tyr15 protein expressions in the miR-219-5p NC group and morphine group were obviously stronger than those in the blank control group (all P<0.05). In the miR-219-5p mimic group, WEE1 and Tyr15 protein expressions were significantly lower compared with those in the miR-219-5p NC group and morphine group (all P<0.05). CONCLUSIONS Morphine significantly downregulated the expression of miRNA-219-5p, which targets WEE1 to suppress Tyr15 expressions and activate Cdc2, thus inhibiting

  2. 41 CFR 302-3.219 - Is there a limit on how many times I may receive reimbursement for tour renewal travel?

    Science.gov (United States)

    2010-07-01

    ... many times I may receive reimbursement for tour renewal travel? 302-3.219 Section 302-3.219 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES RELOCATION....219 Is there a limit on how many times I may receive reimbursement for tour renewal travel? (a) If...

  3. Field Trial of 40 Gbit/s ETDM Prototype System over 219 km of Installed Single Mode Fiber

    Institute of Scientific and Technical Information of China (English)

    Sang Soo Lee; Hyun Woo Cho; Sang Kyu Lim; Ki Ho Han; Jin Soo Han; Moo Jung Chu; Je Soo Ko; Kyeong-Mo Yoon; Yong-Gi Lee

    2003-01-01

    Transmission of 40Gbit/s NRZ signal was successfully demonstrated over 219km of installed SMF in KT's Daejeon area network. After transmission, the measured power penalty was 0.5dB for all the tributary channels.

  4. The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model.

    Science.gov (United States)

    Murai, Kiyohito; Sun, Guoqiang; Ye, Peng; Tian, E; Yang, Su; Cui, Qi; Sun, Guihua; Trinh, Daniel; Sun, Olivia; Hong, Teresa; Wen, Zhexing; Kalkum, Markus; Riggs, Arthur D; Song, Hongjun; Ming, Guo-Li; Shi, Yanhong

    2016-01-01

    Dysregulated expression of miR-219, a brain-specific microRNA, has been observed in neurodevelopmental disorders, such as schizophrenia (SCZ). However, its role in normal mammalian neural stem cells (NSCs) and in SCZ pathogenesis remains unknown. We show here that the nuclear receptor TLX, an essential regulator of NSC proliferation and self-renewal, inhibits miR-219 processing. miR-219 suppresses mouse NSC proliferation downstream of TLX. Moreover, we demonstrate upregulation of miR-219 and downregulation of TLX expression in NSCs derived from SCZ patient iPSCs and DISC1-mutant isogenic iPSCs. SCZ NSCs exhibit reduced cell proliferation. Overexpression of TLX or inhibition of miR-219 action rescues the proliferative defect in SCZ NSCs. Therefore, this study uncovers an important role for TLX and miR-219 in both normal neurodevelopment and in SCZ patient iPSC-derived NSCs. Moreover, this study reveals an unexpected role for TLX in regulating microRNA processing, independent of its well-characterized role in transcriptional regulation. PMID:26965827

  5. Polychlorinated biphenyls (PCB) analysis report for solid sample from 219S tank 101

    Energy Technology Data Exchange (ETDEWEB)

    Diaz, L.A.

    1998-02-04

    One waste sample that was obtained with solids from tank 101 of 219S via a peristaltic pump equipped with a stainless steel tube and Norprene tubing (Phthalate free) was obtained in a glass jar with teflon lid was analyzed (with duplicate, matrix spike, and matrix spike duplicate) for PCBs as Aroclor mixtures by the Inorganic/Organic Chemistry Group. A soxhlet extraction procedure was used for extraction of the Aroclors from the sample. Analysis was performed using dual column confirmation gas chromatography/electron capture detection (GC/ECD). Results are presented.

  6. Polychlorinated biphenyls (PCB) analysis report for solid sample from 219S tank 101

    International Nuclear Information System (INIS)

    One waste sample that was obtained with solids from tank 101 of 219S via a peristaltic pump equipped with a stainless steel tube and Norprene tubing (Phthalate free) was obtained in a glass jar with teflon lid was analyzed (with duplicate, matrix spike, and matrix spike duplicate) for PCBs as Aroclor mixtures by the Inorganic/Organic Chemistry Group. A soxhlet extraction procedure was used for extraction of the Aroclors from the sample. Analysis was performed using dual column confirmation gas chromatography/electron capture detection (GC/ECD). Results are presented

  7. 219.3 W CW diode-side-pumped 1123 nm Nd:YAG laser

    Science.gov (United States)

    Li, C. Y.; Bo, Y.; Xu, Y. T.; Yang, F.; Wang, Z. C.; Wang, B. S.; Xu, J. L.; Gao, H. W.; Peng, Q. J.; Cui, D. F.; Xu, Z. Y.

    2010-07-01

    We demonstrate a high power continuous wave (CW) diode-side-pumped Nd:YAG laser operating at 1123 nm with a plano-plano configuration. By means of precise coating, a single 1123 nm wavelength is achieved. Under the pump power of 1080 W, an output power of 219.3 W is obtained, which corresponds to an optical-optical conversion efficiency of 20.3%. To the best of our knowledge, this is the highest output power for CW 1123 nm laser based on Nd:YAG crystal.

  8. Equation modifying program, L219 (EQMOD). Volume 2: Supplemental system design and maintenance document

    Science.gov (United States)

    Hirayama, M. Y.; Clemmons, R. E.; Miller, R. D.

    1979-01-01

    A digital computer program, L219 (EQMOD), available for execution on the CDC 6600 is described. The program modifies matrices according to card input instructions and prepares magnetic files of matrices suitable for use in the linear systems analysis program (QR) and the random harmonic analysis program L221 (TEV156). The particular field of application of the program is the modification of the theoretical equations of motion and load equations generated in DYLOFLEX by the equation of motion program (L217) and the load equation program (L218), respectively.

  9. ECNJEFI. A JEFI based 219-group neutron cross-section library: User's manual

    International Nuclear Information System (INIS)

    This manual describes the contents of the ECNJEF1 library. The ECNJEF1 library is a JEF1.1 based 219-group AMPX-Master library for reactor calculations with the AMPX/SCALE-system, e.g. the PASC-3 system as implemented at the Netherlands Energy Research Foundation in Petten, Netherlands. The group cross-section data were generated with NJOY and NPTXS/XLACS-2 from the AMPX system. The data on the ECNJEF1 library allows resolved-resonance treatment by NITAWL and/or unresolved resonance self-shielding by BONAMI. These codes are based upon the Nordheim and Bondarenko methods, respectively. (author). 10 refs., 7 tabs

  10. EJ1: a JEF1 based 219-group neutron cross-section library

    International Nuclear Information System (INIS)

    This manual describes the contents of the EJ1 library. The EJ1 library is a JEF1.1 based 219-group AMPX-Master library for reactor calculations with the AMPX/SCALE-3 system, e.g. the PASC-3 system, as implemented at ECN-Petten. The group cross-section data were generated with NJOY. The data on the EJ1 library allow resolved-resonance treatment by NITAWL and unresolved resonance self-shielding by BONAMI. These codes are based upon the Nordheim and Bondarenko methods, respectively. (author). 24 refs., 8 tabs

  11. Purification, crystallization and preliminary X-ray analysis of cytochrome P450 219A1 from Novosphingobium aromaticivorans DSM 12444

    International Nuclear Information System (INIS)

    A 2.4 Å resolution data set was collected from a crystal of CYP219A1. This is the first protein of a new P450 family from the oligotrophic organism N. aromaticivorans which can oxidize steroids and bind sesquiterpenoids. Cytochrome P450 enzymes catalyze a variety of reactions and are widely distributed in living organisms. In recent studies, the first members of five new families of cytochrome P450 enzymes have been identified, including cytochrome P450 219A1 (CYP219A1) from Novosphingobium aromaticivorans DSM 12444. It has also been reported that isolongifolen-9-one (C15H22O), a sesquiterpenoid ketone derivative, is a potential substrate for CYP219A1, inducing a ≥95% shift of the haem spin state to high spin upon binding. The CYP219A1 protein has been crystallized and single crystals have been studied by X-ray crystallography. Diffraction data were collected to 2.4 Å resolution. The crystals belonged to space group P6, with unit-cell parameters a = 93.1, b = 93.1, c = 98.0 Å. Preliminary X-ray diffraction data analysis revealed that the asymmetric unit contained one protein molecule

  12. Synthesis, radiochemistry and biological evaluation of a new somatostatin analogue (SDZ 219-387) labelled with technetium-99m

    International Nuclear Information System (INIS)

    A new derivative of octreotide SDZ 219-387 [PnAO-(D)Phe1-octreotide] was synthesized, which binds specifically and with high affinity to somatostatin receptors in vitro (pKi=9.79±0.16). This new somatostatin analogue chelates technetium-99m under mild labelling conditions in good yields. The resulting [99mTc]SDZ 219-387 was stable up to 6 h after labelling and could be isolated in a pure radiochemical and chemical form by high-perfomance liquid chromatographic purification. The intravenous administration of purified [99mTc]SDZ 219-387 revealed that the radioligand was rapidly cleared from circulation, and tumour uptake of 0.38% ID/g was observed at 1.5 h post injection. [99mTc]SDZ 219-387 specifically interacted with somatostatin binding sites on the tumour. However, the radioligand is highly lipophilic and excreted mainly through the hepatobiliary system. As a consequence, [99mTc]SDZ 219-387 exhibits increased background activity and therefore is not appropriate for the in vivo visualization of somatostatin receptor-positive tumours and/or their metastases in the abdomen. (orig.)

  13. Treatment of cultured glioma cells with the EGFR-TKI gefitinib (''Iressa'', ZD1839) increases the uptake of astatinated EGF despite the absence of gefitinib-mediated growth inhibition

    International Nuclear Information System (INIS)

    The EGFR-TKI (epidermal growth factor receptor tyrosine kinase inhibitor) gefitinib (''Iressa'', ZD1839), a reversible growth inhibitor of EGFR-expressing tumour cells, has been shown to enhance the antitumour effect of ionising radiation, and also to increase the uptake of radioiodinated EGF. Thus, combination of gefitinib treatment and radionuclide targeting is an interesting option for therapy of brain tumours that are difficult to treat with conventional methods. The aim of this study was to evaluate how pre-treatment with gefitinib affects binding of astatinated EGF (211At-EGF) to cultured glioma U343 cells, which express high levels of EGFR. The growth of U343 cells in the presence of gefitinib was investigated, and it was found that gefitinib does not significantly inhibit the growth of these cells. Nevertheless, the uptake of 211At-EGF in U343 cells was markedly increased (up to 3.5 times) in cells pre-treated with gefitinib (1 μM). This indicates that a combination of gefitinib treatment and radionuclide targeting to EGFR might be a useful therapeutic modality, even for patients who do not respond to treatment with gefitinib alone. (orig.)

  14. Photo-dynamical mass determination of the multi-planetary system K2-19

    CERN Document Server

    Barros, S C C; Demangeon, O; Tsantaki, M; Santerne, A; Armstrong, D J; Barrado, D; Brown, D; Deleuil, M; Lillo-Box, J; Osborn, H; Pollacco, D; Abe, L; Andre, P; Bendjoya, P; Boisse, I; Bonomo, A S; Bouchy, F; Bruno, G; Cerda, J Rey; Courcol, B; Díaz, R F; Hébrard, G; Kirk, J; Lachurié, J C; Lam, K W F; Martinez, P; McCormac, J; Moutou, C; Rajpurohit, A; Rivet, J -P; Spake, J; Suarez, O; Toublanc, D; Walker, S R

    2015-01-01

    K2-19 is the second multi-planetary system discovered with K2 observations. The system is composed of two Neptune size planets close to the 3:2 mean-motion resonance. To better characterise the system we obtained two additional transit observations of K2-19b and five additional radial velocity observations. These were combined with K2 data and fitted simultaneously with the system dynamics (photo-dynamical model) which increases the precision of the transit time measurements. The higher transit time precision allows us to detect the chopping signal of the dynamic interaction of the planets that in turn permits to uniquely characterise the system. Although the reflex motion of the star was not detected, dynamic modelling of the system allowed us to derive planetary masses of $M_b= 44 \\pm 12\\, M_{\\oplus}$ and $M_c = 15.9 \\pm 7.0\\, M_{\\oplus}$ for the inner and the outer planets respectively, leading to densities close to Uranus. We also show that our method allows the derivation of mass ratios using only the 80...

  15. Photodynamical mass determination of the multiplanetary system K2-19

    Science.gov (United States)

    Barros, S. C. C.; Almenara, J. M.; Demangeon, O.; Tsantaki, M.; Santerne, A.; Armstrong, D. J.; Barrado, D.; Brown, D.; Deleuil, M.; Lillo-Box, J.; Osborn, H.; Pollacco, D.; Abe, L.; Andre, P.; Bendjoya, P.; Boisse, I.; Bonomo, A. S.; Bouchy, F.; Bruno, G.; Cerda, J. Rey; Courcol, B.; Díaz, R. F.; Hébrard, G.; Kirk, J.; Lachurié, J. C.; Lam, K. W. F.; Martinez, P.; McCormac, J.; Moutou, C.; Rajpurohit, A.; Rivet, J.-P.; Spake, J.; Suarez, O.; Toublanc, D.; Walker, S. R.

    2015-12-01

    K2-19 is the second multiplanetary system discovered with K2 observations. The system is composed of two Neptune size planets close to the 3:2 mean-motion resonance. To better characterize the system we obtained two additional transit observations of K2-19b and five additional radial velocity observations. These were combined with K2 data and fitted simultaneously with the system dynamics (photodynamical model) which increases the precision of the transit time measurements. The higher transit time precision allows us to detect the chopping signal of the dynamic interaction of the planets that in turn permits to uniquely characterize the system. Although the reflex motion of the star was not detected, dynamic modelling of the system allowed us to derive planetary masses of Mb = 44 ± 12 M⊕ and Mc = 15.9 ± 7.0 M⊕ for the inner and the outer planets, respectively, leading to densities close to Uranus. We also show that our method allows the derivation of mass ratios using only the 80 d of observations during the first campaign of K2.

  16. A Novel Functional Missense Mutation p.T219A in Type 1 Gaucher's Disease

    Institute of Scientific and Technical Information of China (English)

    Lin-YuLiu; Fei Liu; Si-Chen Du; Sha-Yi Jiang; Hui-Jun Wang; Jin Zhang; Wei Wang

    2016-01-01

    Background:Gaucher's disease (GD) is an autosomal recessive disorder caused by a deficiency of acid β-glucosidase (glucocerebrosidase [GBA])that results in the accumulation of glucocerebroside within macrophages.Many mutations have been reported to be associated with this disorder.This study aimed to discover more mutations and provide data for the genetic pattern of the gene,which will help the development of quick and accurate genetic diagnostic tools for this disease.Methods:Genomic DNA was obtained from peripheral blood leukocytes of the patient and Sanger sequencing is used to sequence GBA gene.Sequence alignments of mammalian β-GBA (GCase) and three-dimensional protein structure prediction of the mutation were made.A construct of this mutant and its compound heterozygous counterpart were used to measure GCase in vitro.Results:GCase is relatively conserved at p.T219A.This novel mutation differs from its wild-type in structure.Moreover,it also causes a reduction in GCase enzyme activity.Conclusion:This novel mutation (c.655A>G,p.T219A) is a pathogenic missense mutation,which contributes to GD.

  17. 222-S radioactive liquid waste line replacement and 219-S secondary containment upgrade, Hanford Site, Richland, Washington

    International Nuclear Information System (INIS)

    The U.S. Department of Energy (DOE) is proposing to: (1) replace the 222-S Laboratory (222-S) radioactive liquid waste drain lines to the 219-S Waste Handling Facility (219-S); (2) upgrade 219-S by replacing or upgrading the waste storage tanks and providing secondary containment and seismic restraints to the concrete cells which house the tanks; and (3) replace the transfer lines from 219-S to the 241-SY Tank Farm. This environmental assessment (EA) has been prepared in compliance with the National Environmental Policy Act (NEPA) of 1969, as amended, the Council on Environmental Quality Regulations for Implementing the Procedural Provisions of NEPA (40 Code of Federal Regulations [CFR] 1500-1508), and the DOE Implementing Procedures for NEPA (10 CFR 1021). 222-S is used to perform analytical services on radioactive samples in support of the Tank Waste Remediation System and Hanford Site environmental restoration programs. Activities conducted at 222-S include decontamination of analytical processing and support equipment and disposal of nonarchived radioactive samples. These activities generate low-level liquid mixed waste. The liquid mixed waste is drained through pipelines in the 222-S service tunnels and underground concrete encasements, to two of three tanks in 219-S, where it is accumulated. 219-S is a treatment, storage, and/or disposal (TSD) unit, and is therefore required to meet Washington Administrative Code (WAC) 173-303, Dangerous Waste Regulations, and the associated requirements for secondary containment and leak detection. The service tunnels are periodically inspected by workers and decontaminated as necessary to maintain as low as reasonably achievable (ALARA) radiation levels. Although no contamination is reaching the environment from the service tunnels, the risk of worker exposure is present and could increase. 222-S is expected to remain in use for at least the next 30 years to serve the Hanford Site environmental cleanup mission

  18. Project specific quality assurance plan for Project W-178, 219-S secondary containment

    International Nuclear Information System (INIS)

    The scope of this Quality Assurance Program Plan (QAPP) is to provide a system of Quality Assurance reviews and verifications on the design, procurement and construction of the 219-S Secondary Containment Upgrade. The reviews and verifications will be on activities associated with design, procurement, and construction of the Secondary Containment Upgrade which includes, but is not limited to demolition, removal, new tank installation, tank 103 isolation, tank cell refurbishment, electrical, instrumentation, piping/tubing including supports, pump and valves, and special coatings. The full project scope is defined in the project Functional Design Criteria (FDC), SD-W178-FDC-001, and all activities must be in compliance with this FDC and related design documentation

  19. Measurement of the (211)Pb half-life using recoil atoms from (219)Rn decay.

    Science.gov (United States)

    Aitken-Smith, P M; Collins, S M

    2016-04-01

    The radioactive half-life of (211)Pb was measured, by α-particle counting of samples of radiochemically pure (211)Pb in equilibrium with its α-emitting progeny, (211)Bi and (211)Po. The samples were prepared by the collection of (215)Po recoil atoms from the decay of the (219)Rn decay progeny produced from a (223)Ra sample onto stainless steel discs. The radioactive decay of the (211)Pb was measured utilising a 2π proportional counter operating on the α plateau. A half-life of 36.164 (13)min was determined, which is in agreement with currently available literature. A full uncertainty budget is presented. A recommended half-life of T1/2((211)Pb)=36.161 (17)min has been evaluated from the current literature values. PMID:26773817

  20. MicroRNA-219-2-3p functions as a tumor suppressor in gastric cancer and is regulated by DNA methylation.

    Directory of Open Access Journals (Sweden)

    Huizi Lei

    Full Text Available BACKGROUND AIMS: Gastric cancer is the most frequent gastrointestinal tumor in adults and is the most lethal form of human cancer. Despite of the improvements in treatments, the underlying mechanism of gastric carcinogenesis is not well known. To define novel modulators that regulate susceptibility to tumorgenesis, we focused on miR-219-2-3p. METHODS: Quantitative RT-PCR was employed to investigate the level of miR-219-2-3p in gastric cancer (GC tissues (n = 113 and their matched adjacent normal tissues (n = 113. In vitro cell proliferation, apoptosis assays, cell migration, and invasion assays were performed to elucidate biological effects of miR-219-2-3p. Since silencing of miRNA by promoter CpG island methylation may be an important mechanism in tumorgenesis, GC cells were treated with 5-aza-2'-deoxycytidine and trichostatin A, and expression changes of miR-219-2-3p were subsequently examined by quantitative RT-PCR. Finally, the methylation status of CpG island upstream of miR-219-2-3p was analyzed by methylation-specific PCR in GC tissues (n = 22. RESULTS: miR-219-2-3p was down-regulated in GC and cell lines. In addition, the experiments documented the lower expression of miR-219-2-3p in GC specimens with higher grade and later stage tumors. Meanwhile, miR-219-2-3p exerted antiproliferative, proapoptotic, and antimetastatic roles and reduced levels of p-ERK1/2 in GC cells. Furthermore, 5-aza-2'-deoxycytidine and trichostatin A increased the expression (~2 fold of miR-219-2-3p in GC cells. By methylation-specific PCR, DNA methylation in the upstream region of miR-219-2-3p was detected in both adjacent normal tissues and cancer tissues. As expected, the methylation level was considerably higher in the miR-219-2-3p down-regulated group than up-regulated group. CONCLUSIONS: miR-219-2-3p is potentially involved in gastric cancer progression and metastasis by regulating ERK1/2-related signal pathways, which may provide a novel therapeutic strategy

  1. Spectroscopy of nuclei 215Fr and 219 Ac: a contribution to the study of the nuclear structure of light actinides

    International Nuclear Information System (INIS)

    Using α-particle and γ-ray spectroscopy, it has been possible to establish the high spin pattern in 215Fr and propose a decay scheme up to Iπ = (47/2+) containing six isomeric states. These results are interpreted using the recent version of the deformed Woods-Saxon model and the Strutinsky normalisation technique. A similar study in 219 Ac has revealed the existence of two quasi-bands each formed of states of alternating parity and connected by strong E1 transitions. This data for 219Ac fits better with the stable octupole deformation model, mainly because of the high-spin parity doublets observed for the first time, than with the α-cluster model

  2. Germination Response of MR 219 Rice Variety to Different Exposure Times and Periods of 2450 MHz Microwave Frequency

    OpenAIRE

    Daryush Talei; Alireza Valdiani; Mahmood Maziah; Mohammad Mohsenkhah

    2013-01-01

    Germination is a key process in plants' phenological cycles. Accelerating this process could lead to improvment of the seedling growth as well as the cultivation efficiency. To achieve this, the effect of microwave frequency on the germination of rice seeds was examined. The physiological feedbacks of the MR 219 rice variety in terms of seed germination rate (GR), germination percentage (GP), and mean germination time (MGT) were analyzed by exposing its seeds to 2450 MHz of microwave frequenc...

  3. {sup 18}F-labeling and biodistribution of the novel fluoro-quinolone antimicrobial agent, trovafloxacin (CP 99,219)

    Energy Technology Data Exchange (ETDEWEB)

    Babich, John W.; Rubin, Robert H.; Graham, Wendy A.; Wilkinson, Robert A.; Vincent, John; Fischman, Alan J

    1996-11-01

    [{sup 18}F]CP 99,219 [(1{alpha},5{alpha},6{alpha})-7-(6-amino-3-azabicyclo [3.1.0]hex-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid] was prepared by {sup 18}F for {sup 19} exchange followed by reverse-phase HPLC purification. Studies of the effects of reaction time and temperature on {sup 18}F incorporation demonstrated that heating 1.0 mg of CP 99,219 in 0.5 cc of DMSO with 4.5 mg of K{sub 2}CO{sub 3} and 24 mg of Kryptofix for 15 min at 160 deg. C results in the optimal compromise between radiochemical yield and purity. This method routinely provides radiochemical yields of 15-30% [EOS] with radiochemical purities of >97%. Varying the concentration of CP 99,219 in the reaction mixture had no effect on yield. Biodistribution studies in rats demonstrated that significant concentrations of drug accumulate in most tissues. The tissues with the highest concentrations of drug were intestine, liver, kidney, and stomach.

  4. Clinical analysis for 219 cases of moderate and severe ovarian hyperstimulation syndrome%中、重度卵巢过度刺激综合征219例临床分析

    Institute of Scientific and Technical Information of China (English)

    胡晶晶; 魏兆莲; 周平; 邹薇薇; 曹云霞

    2011-01-01

    Objective To investigate the clinical characteristics, treatment and prevention of ovarian hypers-timulation syndrome (OHSS) in assisted reproduction techniques (ART). Methods Clinical data of 219 moderate and severe OHSS cases who were received in vitro fertilization- embryo transfer (IVF- ET) or intracytoplasmic sperm injection (ICSI) in the First Affiliated Hospital of Anhui Medical University from March 2007 to December 2010, were analyzed retrospectively. Results OHSS occurred after controlled ovarian hyperstimulation treatment, the incidence was about 4. 2% (219/5 176). 177 (80. 8%) were moderate OHSS and 42 (19. 2%) were severe OHSS. The distribution of severe OHSS patients between early group (18 cases, 8.2%) and late group (24 cases, 11.0%) was signifiant different (P0. 05).Conclusions The clinical features of early and late onset group were quite different. Multiple pregnance was the risk factor of OHSS. Cryopreserving all embryos on the day of transfer or choose single embryo transfer can reduce the duration of OHSS symptoms effectively .%目的 研究辅助生殖技术中卵巢过度刺激综合征(ovarian hyperstimulation syndrome,OHSS)的临床特点、治疗和预防.方法 对安徽医科大学第一附属医院生殖中心2007年3月至2010年12月行体外受精-胚胎移植(in vitro fertilization- embryo transfer,IVF- ET)和卵细胞浆内单精子注射(intracytoplasmic sperm injection,ICSI)中发生中、重度OHSS的219例患者的临床资料进行回顾性分析.结果 在219例患者中,OHSS发生率的为4.2% (219/5 176),其中重度OHSS 42例(19.2%),中度OHSS 177例(80.8%).早发组重度OHSS发生率(18例,8.2%)与晚发组(24例,11.0%)比较,差异有统计学意义(P<0.001);取卵后发生OHSS的时间为l~19d,早发组平均发生时间为(2.2±1.8)d,晚发组为(12.4±3.4)d(P<0.001).主要表现为腹胀、恶心、呕吐和少量腹水患者占80.8% (177/219);合并胸水、少尿、血液浓缩、水电解

  5. Early prodromal symptoms and diagnoses before first psychotic episode in 219 inpatients with schizophrenia.

    Science.gov (United States)

    Shioiri, Toshiki; Shinada, Keita; Kuwabara, Hideki; Someya, Toshiyuki

    2007-08-01

    The authors examined the diagnosis before the onset of schizophrenia and retrospectively evaluated the presence/absence of early prodromal symptoms (EPS) and their types (such as depressive symptoms, anxiety symptoms, and obsessive-compulsive [OC] symptoms) and the period from the onset of these symptoms to that of schizophrenia in 219 inpatients with schizophrenia diagnosed according to the DSM-IV(-TR). A diagnosis was made before the onset of schizophrenia in 53 patients (24.2%). The diagnoses were mood disorder in 39 patients, anxiety disorder in seven, obsessive-compulsive disorder (OCD) in three, adjustment disorder in two, and eating disorder in two. EPS were present in 65 (29.7%) of all patients, slightly more frequent in female patients (male:female = 1:1.41). In the group with EPS, depressive symptoms (61.5%) were most frequently observed, followed by anxiety symptoms (23.1%) and OC symptoms (9.2%). The age at onset for each type of symptom was significantly lower for OC symptoms (14.5 +/- 2.4 years) than for the other symptoms (approx. 20 years). The mean period from the onset of each symptom to that of schizophrenia was the shortest for depressive symptoms (2.7 +/- 3.1 years) and the longest (>4 years) for OC symptoms. These results as well as previous studies in Western countries showed that more non-specific and general symptoms are frequently present for some years before the onset of schizophrenia. With consideration of this point, efforts toward early detection of schizophrenia are important. PMID:17610658

  6. ZZ AMPX-2/123, 123-Group Neutron Cross-Section Library from ENDF/B-4 by AMPX-2. ZZ AMPX-2/219, 219-Group Neutron Cross-Section Library from ENDF/B-4 by AMPX-2

    International Nuclear Information System (INIS)

    1 - Description of problem or function: Format: 'data base' for subsequent collapsing into both fine and broad group data in various formats (working and/or weighted ANISN, CCCC, etc.). Number of groups: AMPX-2/123 → 123 group structure; AMPX-2/219219 group structure. Nuclides: H, He, Li, Be, B, C, N, O, F, Na, Mg, Al, Si, Cl, K, Ca, Ti, V, Cr, Mn, Fe, Ni, Cu, Kr, Zirc, Mo, Tc, Rh, Ag, Cd, Xe, Sm, Eu, Gd, Dy, Cu, Ta, W, Re, Pb, Th, Pa, U, Np, Pu, Am, Cm. Origin: ENDF/B-IV. Weighting spectrum: Most data were generated using a standard flux over three energy ranges (fission - 1/E - Maxwellian) as point-to-fine-group cross sections weighing function. The AMPX-2 P3 123- and 219- Group Neutron Cross-Section Master Interface Libraries may be considered as 'data bases' for subsequent collapsing into both fine and broad group data in various formats (working and/or weighted ANISN, CCCC, etc.). The built-in 123 and 219 group structures have been used to process all available data of ENDF/B-IV. 2 - Method of solution: The program AMPX-2 has been used to generate the data. By various executions of the module XLACS-2 (XLACS for bound H-1 in some materials) a number of independent libraries were generated which then were combined using the AMPX-2 module AJAX. Most data were generated using a standard flux over three energy ranges (fission - 1/E - Maxwellian) as point-to-fine-group cross sections weighing function. For some structural materials (e.g. Fe, Cr,...) different master data sets were produced using a weighting function fission - 1/E sigma T(SS-304) - Maxwellian, and the three parts of the spectrum were joined at properly selected energies. For some nuclides (e.g. 238U and 240Pu) various master data sets have been produced which contain problem-dependent unresolved cross sections characterized by the associated potential scattering cross sections. Some data sets contain P3 thermal scattering matrices, for which ENDF/B File 7 S(alpha, beta) data were used, e

  7. High frequency plant regeneration from mature seed of elite, recalcitrant Malaysian indica rice ( Oryza sativa L.) CV. MR 219.

    Science.gov (United States)

    Sivakumar, P; Law, Y S; Ho, C-L; Harikrishna, Jennifer Ann

    2010-09-01

    An efficient in vitro plant regeneration system was established for elite, recalcitrant Malaysian indica rice, Oryza sativa L. CV. MR 219 using mature seeds as explant on Murashige and Skoog and Chu N6 media containing 2,4-dichlorophenoxy acetic acid and kinetin either alone or in different combinations. L-proline, casein hydrolysate and L-glutamine were added to callus induction media for enhancement of embryogenic callus induction. The highest frequency of friable callus induction (84%) was observed in N6 medium containing 2.5 mg l(-1) 2,4-dichlorophenoxy acetic acid, 0.2 mg l(-1) kinetin, 2.5 mg l(-1) L-proline, 300 mg l(-1) casein hydrolysate, 20 mg l(-1) L-glutamine and 30 g l(-1) sucrose under culture in continuous lighting conditions. The maximum regeneration frequency (71%) was observed, when 30-day-old N6 friable calli were cultured on MS medium supplemented with 3 mg l(-1) 6-benzyl aminopurine, 1 mg l(-1) naphthalene acetic acid, 2.5 mg l(-1) L-proline, 300 mg l(-1) casein hydrolysate and 3% maltose. Developed shoots were rooted in half strength MS medium supplemented with 2% sucrose and were successfully transplanted to soil with 95% survival. This protocol may be used for other recalcitrant indica rice genotypes and to transfer desirable genes in to Malaysian indica rice cultivar MR219 for crop improvement. PMID:20724277

  8. Amylose Content and Grain Length of New Rice Transgressive Variants Derived from a Cross Between O. rufipogon and Malaysian Rice Cultivar MR219

    Directory of Open Access Journals (Sweden)

    Parviz Fasahat

    2012-01-01

    Full Text Available Amylose content is one of the important grain quality properties of rice. A total of 10 new rice genotypes (BC2F7 generation derived from a cross between O. rufipogon Griff. accession IRGC105491 and O. sativa subspecies indica cv. MR219 with high yield were evaluated for amylose content in three environments in Peninsular Malaysia. One of the parents, a popular high yielding Malaysian rice cultivar MR219 was used as a check. Based on the average amylose content across the environments, the genotype G13 showed significantly (p < 0.05 different amylose content (23.88 % in comparison to other genotypes. Two genotypes G13 (25.7% and G15 (25.6% were higher than MR219 (25.1% in terms of amylose content in Sungai Besar environment. There was a positive (r2=0.018 but no significant correlation between amylose content and grain length.

  9. Association between apolipoprotein E promoter-219G/T polymorphism and total cholesterol level in patients with Alzheimer disease

    Institute of Scientific and Technical Information of China (English)

    Fang Liu; Xiao Sun; Jing Wang; Yan Kong; Li Cui; Xiangdang Shi

    2006-01-01

    BACKGROUND: Many researches have suggested that apolipoprotein E (APOE) and total cholesterol metabolism are closely related with dementia. In the supposed theory, 219 site of APOE promoter region is near gene coding region, so its polymorphism may result in the abnormality of APOE gene and protein expression,and finally lead to dementia.OBJECTIVE: To observe the association between APOE promoter-219G/T polymorphisms with serum total cholesterol in patients with Alzheimer disease, and compare it with non-dementia people.DESIGN: Case-control, comparative observation.SETTING: Department of Neurology, Fengtian Hospital of Shenyang Medical College.PARTICIPANTS: Fifty-five dementia patients including 27 males and 28 females aged (66±3) years and treated in the Department of Neurology, Fengtian Hospital were selected from January 2002 to December 2005 as the Alzheimer disease group. They all diagnosed according to the DSM- Ⅳ diagnostic criteria of Alzheimer disease instituted by American Psychiatry Association in 1994. Meanwhile, 44 none-dementia patients including 21 males and 23 females aged (66±3) years were selected from other clinical departments of Fengtian Hospital as control group. All the participants were informed the detection and agreed.METHODS: Genomic DNA was extracted from the peripheral blood of all subjects, then "NEST"PCR, DNA sequence and enzyme digestion were adopted to detect the expression of APOE promoter-219 polymorphism,following by biomedical statistics analysis based on the clinical total cholesterol level.MAIN OUTCOME MEASURES: Polymorphism of APOEpromoter-219 G/T and total cholesterol level.RESULTS: All 55 dementia patients and 44 non-dementia ones were involved in the result analysis. ①Allele and genotype frequency: The T allele frequency of the Alzheimer disease group was significantly higher than that in the control group [88.2% (97/110), 54.5% (48/88)], while G allele frequency was remarkably lower than that in the control group [11

  10. Amylose Content and Grain Length of New Rice Transgressive Variants Derived from a Cross Between O. rufipogon and Malaysian Rice Cultivar MR219

    OpenAIRE

    Parviz Fasahat; Kharidah Muhammad; Aminah Abdullah; Wickneswari Ratnam

    2012-01-01

    Amylose content is one of the important grain quality properties of rice. A total of 10 new rice genotypes (BC2F7 generation) derived from a cross between O. rufipogon Griff. accession IRGC105491 and O. sativa subspecies indica cv. MR219 with high yield were evaluated for amylose content in three environments in Peninsular Malaysia. One of the parents, a popular high yielding Malaysian rice cultivar MR219 was used as a check. Based on the average amylose content across the environments, the g...

  11. 冠心病患者ABCA1基因R219K多态性分析%Polymorphism of R219K of ABCA1 gene in patients with coronary artery disease

    Institute of Scientific and Technical Information of China (English)

    王旭东; 傅研; 姜惠杰

    2004-01-01

    目的:探讨三磷酸腺苷(ATP)结合盒子转运体1(ATP-binding cassette transporter 1;ABC1,ABCAI)基因多态性与冠心病(CHD)发病和病情程度的相关性.方法:使用多聚合酶链式反应(PCR)和错配酶促切割法检测了222例CHD患者和278例健康对照者的DNA,分析了该基因编码区R219K多态性位点的不同基因型频率,其分布特点以及与血脂、CHD疾病程度的相关性.结果:R219K的变异等位基因频率CHD组和对照组分别为43.9%、50.2%,P <0.05,变异基因型(KK)携带者频率在急性冠状动脉综合征(ACS)组:稳定型心绞痛(SAP)组:对照组为20.0%:26.9%:27.7%,其ACS组与对照组差异有统计学意义(P<0.05),而SAP组与对照组差异无统计学意义(P>0.05).CHD组中KK基因型携带者的三酰甘油(TG)水平低于RR基因型携带者[(1.31±0.62):(1.56±0.63)mmol/L,P<0.05],而高密度脂蛋白水平高于后者[(1.01±0.12):(0.96±0.14)mmol/L,P<0.05].结论:ABCA1基因R219K多态性不仅与血脂水平并与CHD发病及病情严重程度明显相关.由于总体对象中K等位基因具有较高的频率(47%),计算的人群归因危险度结果提示,使本研究对象中CHD的患者减少了12%.

  12. Astatination of closo-dodecaborate(2-) anion

    Czech Academy of Sciences Publication Activity Database

    Orlova, A.; Lebeda, Ondřej; Tolmachev, V.; Lundquist, H.; Carlsson, J.; Sjöberg, S.

    Cambridge : The Royal Society of Chemistry , 2000 - (Davidson, M.; Hughes, A.; Marder, T.; Wade , K.), s. 144-147 [Conference "Contemporary Boron Chemistry ". Durham (GB), 11.07.1999-15.07.1999] Institutional research plan: CEZ:AV0Z1048901 Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders

  13. Implementation in the reaction code system EMPIRE-2.19 of an advanced formalism for fission cross-section calculation

    International Nuclear Information System (INIS)

    Full text: The implementation in the reaction code system EMPIRE-2.19 of an advanced formalism for fission cross-section calculation has been completed. The formalism is based on the optical model for fission and can be applied for nuclei exhibiting double- or triple-humped barrier starting from sub-barrier excitation energies. The optical model for fission, initially developed to describe the resonant structure of the fission cross section at sub-barrier excitation energies due to the vibrational states in the second well of a double-humped fission barrier, was extended to light actinides by including the relations for the transmission coefficients through a complex triple-humped fission barrier. The real part of the fission barrier is parameterised as a function of the nucleus deformation by five smoothly joined parabolas. The imaginary potential is introduced only in the deformation range corresponding to the second well because the tertiary well is supposed to be shallow enough to neglect the damping of class III vibrational states. The transition states are assumed to be rotational states built on vibrational or non-collective band-heads. As the excitation energy increases, the shell effect, which causes the splitting of the outer barrier, diminishes and the outer humps lump into a single one. Therefore, in the present formalism, triple-humped barriers are associated only to the discrete transition states; the contribution of continuum to the fission coefficients is calculated considering a double-humped barrier. The parameters of the second single barrier equivalent with the outer humps are being determined from the condition of equal transmission coefficients. The saddle-point transition states in continuum are described by level densities (BCS below the critical energy and a modified version of Fermi Gas above) accounting for collective enhancements specific to the nuclear shape asymmetry at each saddle point . The neutron cross sections of 232Th in the

  14. 75 FR 32773 - Auction of 218-219 MHz Service and Phase II 220 MHz Service Licenses Scheduled for December 7...

    Science.gov (United States)

    2010-06-09

    ... and impede the deployment of service to the public, and an additional default payment of more than... COMMISSION Auction of 218-219 MHz Service and Phase II 220 MHz Service Licenses Scheduled for December 7... overnight U.S. Postal Service mail. All filings must be addressed to the Commission's Secretary, Attn:...

  15. 17 CFR 274.219 - Form N-17f-1, cover page for each certificate of accounting of securities and similar investments...

    Science.gov (United States)

    2010-04-01

    ... each certificate of accounting of securities and similar investments of a management investment company.... Editorial Note: For Federal Register citations affecting Form N-17f-1, see the List of CFR Sections Affected... PRESCRIBED UNDER THE INVESTMENT COMPANY ACT OF 1940 Forms for Other Statements § 274.219 Form N-17f-1,...

  16. Germination Response of MR 219 Rice Variety to Different Exposure Times and Periods of 2450 MHz Microwave Frequency

    Directory of Open Access Journals (Sweden)

    Daryush Talei

    2013-01-01

    Full Text Available Germination is a key process in plants' phenological cycles. Accelerating this process could lead to improvment of the seedling growth as well as the cultivation efficiency. To achieve this, the effect of microwave frequency on the germination of rice seeds was examined. The physiological feedbacks of the MR 219 rice variety in terms of seed germination rate (GR, germination percentage (GP, and mean germination time (MGT were analyzed by exposing its seeds to 2450 MHz of microwave frequency for one, four, seven, and ten hours. It was revealed that exposing the seeds to the microwave frequency for 10 hours resulted in the highest GP. This treatment led to 100% of germination after three days with a mean germination time of 2.1 days. Although the other exposure times of microwave frequency caused the moderate effects on germination with a GPa3 ranged from 93% to 98%, they failed to reduce the MGTa3. The results showed that ten-hour exposure times of microwave frequency for six days significantly facilitated and improved the germination indices (primary shoot and root length. Therefore, the technique is expected to benefit the improvement of rice seed germination considering its simplicity and efficacy in increasing the germination percentage and rate as well as the primary shoot and root length without causing any environmental toxicity.

  17. Introgression of Blast Resistance Genes (Putative Pi-b and Pi-kh) into Elite Rice Cultivar MR219 through Marker-Assisted Selection

    OpenAIRE

    Tanweer, Fatah A.; Rafii, Mohd Y.; Sijam, Kamaruzaman; Rahim, Harun A.; Ahmed, Fahim; ASHKANI, SADEGH; Latif, Mohammad A.

    2015-01-01

    Blast is the most common biotic stress leading to the reduction of rice yield in many rice-growing areas of the world, including Malaysia. Improvement of blast resistance of rice varieties cultivated in blast endemic areas is one of the most important objectives of rice breeding programs. In this study, the marker-assisted backcrossing strategy was applied to improve the blast resistance of the most popular Malaysian rice variety MR219 by introgressing blast resistance genes from the Pongsu S...

  18. Influence of ATP-Binding Cassette Transporter 1 R219K and M883I Polymorphisms on Development of Atherosclerosis: A Meta-Analysis of 58 Studies

    OpenAIRE

    Yin, Yan-Wei; Li, Jing-Cheng; Gao, Dong; Chen, Yan-Xiu; Li, Bing-Hu; Wang, Jing-Zhou; Liu, Yun; Liao, Shao-Qiong; Zhang, Ming-Jie; Chang-yue GAO; Zhang, Li-li

    2014-01-01

    Background Numerous epidemiological studies have evaluated the associations between ATP-binding cassette transporter 1 (ABCA1) R219K (rs2230806) and M883I (rs4149313) polymorphisms and atherosclerosis (AS), but results remain controversial. The purpose of the present study is to investigate whether these two polymorphisms facilitate the susceptibility to AS using a meta-analysis. Methods PubMed, Embase, Web of Science, Medline, Cochrane database, Clinicaltrials.gov, Current Controlled Trials,...

  19. 76 FR 70336 - Airworthiness Directives; Rolls-Royce plc RB211-524G2-19; -524G2-T-19; -524G3-19; -524G3-T-19...

    Science.gov (United States)

    2011-11-14

    ... April 11, 2000 (65 FR 19477-78). Authority for This Rulemaking Title 49 of the United States Code... Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant economic impact, positive or... plc RB211-524G2-19; -524G2- T-19; -524G3-19; -524G3-T-19; 524H2-19; -524H2-T-19; -524H-36; and -...

  20. Corrective Action Investigation Plan for Corrective Action Unit 219: Septic Systems and Injection Wells, Nevada Test Site, Nevada, Rev. No.: 0

    Energy Technology Data Exchange (ETDEWEB)

    David A. Strand

    2005-01-01

    The Corrective Action Investigation Plan for Corrective Action Unit 219, Septic Systems and Injection Wells, has been developed in accordance with the ''Federal Facility Agreement and Consent Order'' (1996) that was agreed to by the State of Nevada, the U.S. Department of Energy, and the U.S. Department of Defense. The purpose of the investigation is to ensure that adequate data are collected to provide sufficient and reliable information to identify, evaluate, and select technically viable corrective actions. Corrective Action Unit 219 is located in Areas 3, 16, and 23 of the Nevada Test Site, which is 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 219 is comprised of the six Corrective Action Sites (CASs) listed below: (1) 03-11-01, Steam Pipes and Asbestos Tiles; (2) 16-04-01, Septic Tanks (3); (3) 16-04-02, Distribution Box; (4) 16-04-03, Sewer Pipes; (5) 23-20-01, DNA Motor Pool Sewage and Waste System; and (6) 23-20-02, Injection Well. These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Additional information will be obtained by conducting a corrective action investigation prior to evaluating corrective action alternatives and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document.

  1. Characterization of the K2-19 Multiple-Transiting Planetary System via High-Dispersion Spectroscopy, AO Imaging, and Transit Timing Variations

    CERN Document Server

    Narita, Norio; Fukui, Akihiko; Hori, Yasunori; Sanchis-Ojeda, Roberto; Winn, Joshua N; Ryu, Tsuguru; Kusakabe, Nobuhiko; Kudo, Tomoyuki; Onitsuka, Masahiro; Delrez, Laetitia; Gillon, Michael; Jehin, Emmanuel; McCormac, James; Holman, Matthew; Izumiura, Hideyuki; Takeda, Yoichi; Tamura, Motohide; Yanagisawa, Kenshi

    2015-01-01

    K2-19 (EPIC201505350) is a unique planetary system in which two transiting planets with radii ~ 7 $R_{Earth}$ (inner planet b) and ~ 4 $R_{Earth}$ (outer planet c) have orbits that are nearly in a 3:2 mean-motion resonance. Here, we present results of ground-based follow-up observations for the K2-19 planetary system. We have performed high-dispersion spectroscopy and high-contrast adaptive-optics imaging of the host star with the HDS and HiCIAO on the Subaru 8.2m telescope. We find that the host star is relatively old (>8 Gyr) late G-type star ($T_{eff}$ ~ 5350 K, $M_s$ ~ 0.9 $M_{Sun}$, and $R_{s}$ ~ 0.9 $R_{Sun}$). We do not find any contaminating faint objects near the host star which could be responsible for (or dilute) the transit signals. We have also conducted transit follow-up photometry for the inner planet with KeplerCam on the FLWO 1.2m telescope, TRAPPISTCAM on the TRAPPIST 0.6m telescope, and MuSCAT on the OAO 1.88m telescope. We confirm the presence of transit-timing variations, as previously re...

  2. Yield Traits, Physico-chemical Characteristics and Nutritional Composition of MR219 M3 Generation and its Effect on Glycemic Index and Responses in Animal Model

    International Nuclear Information System (INIS)

    Mutation technique is a conventional breeding technique and it is very effective in improving of main crop characteristics such as yield traits, resistance to diseases and pests and nutritional qualities. In this study, MR219 seeds were treated with Carbon ion radiation (60 Gy) by AVF-Cyclotron at the Japan Atomic Energy Research Institute (JAERI), Takasaki, Japan and were planted at the Malaysian Nuclear Agency up to third mutant generation (M3). Thirty one M3 mutant lines (ML1 to ML31) were evaluated on morphological, yield and yield components, and were compared to the parental variety, MR219. Analysis of variance revealed that there was a significant difference among mutant lines in culm height, days to flowering, number of tillers, number of panicles, 1000 grain weight, total grain weight, total of dry matter, alkaline spreading value, gel consistency, amylose content, ash, crude protein, fat, dietary fibre, carbohydrate and energy. Mutant line ML21 had the best performance in majority of yield components and vegetative traits as compared to others mutant lines and parental variety. For nutritional composition, mutant lines namely ML31, ML21, ML10, ML19 were improved in crude protein content, dietary fibre and carbohydrate content. The estimation of glycemic index revealed that two mutant lines namely ML3 and ML30 can be consumed by diabetics. (author)

  3. Corrective Action Decision Document/Closure Report for Corrective Action Unit 219: Septic Systems and Injection Wells, Nevada Test Site, Nevada, Rev. No.: 0

    Energy Technology Data Exchange (ETDEWEB)

    David Strand

    2006-05-01

    This Corrective Action Decision Document/Closure Report has been prepared for Corrective Action Unit (CAU) 219, Septic Systems and Injection Wells, in Areas 3, 16, and 23 of the Nevada Test Site, Nevada, in accordance with the ''Federal Facility Agreement and Consent Order'' (1996). Corrective Action Unit 219 is comprised of the following corrective action sites (CASs): (1) 03-11-01, Steam Pipes and Asbestos Tiles; (2) 16-04-01, Septic Tanks (3); (3) 16-04-02, Distribution Box; (4) 16-04-03, Sewer Pipes; (5) 23-20-01, DNA Motor Pool Sewage and Waste System; and (6) 23-20-02, Injection Well. The purpose of this Corrective Action Decision Document/Closure Report is to provide justification and documentation supporting the recommendation for closure of CAU 219 with no further corrective action beyond the application of a use restriction at CASs 16-04-01, 16-04-02, and 16-04-03. To achieve this, corrective action investigation (CAI) activities were performed from June 20 through October 12, 2005, as set forth in the CAU 219 Corrective Action Investigation Plan and Record of Technical Change No. 1. A best management practice was implemented at CASs 16-04-01, 16-04-02, and 16-04-03, and corrective action was performed at CAS 23-20-01 between January and April 2006. In addition, a use restriction will be applied to CASs 16-04-01, 16-04-02, and 16-04-03 to provide additional protection to Nevada Test Site personnel. The purpose of the CAI was to fulfill the following data needs as defined during the data quality objective (DQO) process: (1) Determine whether contaminants of concern (COCs) are present. (2) If COCs are present, determine their nature and extent. (3) Provide sufficient information and data to complete appropriate corrective actions. The CAU 219 dataset from the investigation results was evaluated based on the data quality indicator parameters. This evaluation demonstrated the quality and acceptability of the dataset for use in fulfilling

  4. HDM2 antagonist MI-219 (spiro-oxindole, but not Nutlin-3 (cis-imidazoline, regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant B-cell lymphomas

    Directory of Open Access Journals (Sweden)

    Sosin Angela M

    2012-09-01

    Full Text Available Abstract Background Lymphomas frequently retain wild-type (wt p53 function but overexpress HDM2, thereby compromising p53 activity. Therefore, lymphoma is a suitable model for studying the therapeutic value of disrupting the HDM2-p53 interaction by small-molecule inhibitors (SMIs. HDM2 have been developed and are under various stages of preclinical and clinical investigation. Previously, we examined the anti-lymphoma activity of MI-319, the laboratory grade of a new class of HDM2 SMI, the spiro-oxindole, in follicular lymphoma. Since then, MI-219, the clinical grade has become readily available. This study further examines the preclinical effects and mechanisms of MI-219 in a panel of human lymphoma cell lines as well as a cohort of patient-derived B-lymphcytes for its potential clinical use. Results Preclinical assessment of MI-219 was evaluated by means of an in vitro and ex vivo approach and compared to Nutlin-3, the gold standard. Characterization of p53 activity and stability were assessed by quantitative PCR, Western blot, and immunoprecipitation. Biological outcome was measured using Trypan blue exclusion assay, Annexin V/PI, PARP and caspase-3 cleavage. Surprisingly, the overall biological effects of Nutlin-3 were more delayed (48 h while MI-219 triggered an earlier response (12-24 h, predominantly in the form of apoptotic cell death. Using a cell free autoubiquitination assay, neither agent interfered with HDM2 E3 ligase function. MI-219 was more effective in upregulating wt-p53 stabilization compared to Nutlin-3. MI-219, but not Nutlin-3, enhanced the autoubiquitination and degradation of HDM2. Conclusions Our data reveals unexpected differences between MI-219 and the well-studied Nutlin-3 in lymphoma cell lines and patient samples. We suggest a novel mechanism for MI-219 that alters the functional activity of HDM2 through enhanced autoubiquitination and degradation. Additionally, this mechanism appears to correspond to biological

  5. Folding model analysis of 58Ni + 64Ni elastic and inelastic scattering at Elab=203.8 and 219.2 MeV

    International Nuclear Information System (INIS)

    Angular distributions of elastic scattering of 58Ni by 64Ni and inelastic scattering leading to the first 2+ state in 58Ni or in 64Ni were measured at Elab=203.8 and 219.2 MeV. The data were analyzed in the frame of the folding model. A renormalization N of the folding potential consistently lower than unity (N∼0.65) is needed to reproduce the elastic scattering data. Coupled-channel calculations including the main inelastic channels explain partly this discrepancy. They reproduce the elastic and inelastic scattering data with a renormalization of N∼0.8 at both energies. Interference between Coulomb and nuclear excitation is shown to play an important role in the repulsive character of the polarization potential. (author) 38 refs.; 6 figs.; 1 tab

  6. Determination of optimum welding parameters in connecting high alloyed X53CrMnNiN219 and X45CrSi93 steels by friction welding

    Indian Academy of Sciences (India)

    Mehmet Uzkut; Bekir Sadik Ünlü; Mustafa Akdağ

    2011-07-01

    In this study, different welding parameters were applied to two different steels with high alloys and mechanical and metallographical investigations are performed. Thus, the optimum welding parameters were determined for these materials and working conditions. 12.30 diameter steel bars made up of 1.4871 (X53CrMnNiN219) and 1.4718 (X45CrSi93) steel were used as experimental material. The material loss increased with increase in friction and rotating pressure. No fracture at the welding region was observed and the highest fracture energy was identified in B5 group. Based on micro hardness investigation; the hardness profile reached its minimum value at the welding region.

  7. Transient climate simulations of the deglaciation 21-9 thousand years before present; PMIP4 Core experiment design and boundary conditions

    Science.gov (United States)

    Ivanovic, Ruza; Gregoire, Lauren; Kageyama, Masa; Roche, Didier; Valdes, Paul; Burke, Andrea; Drummond, Rosemarie; Peltier, W. Richard; Tarasov, Lev

    2016-04-01

    The last deglaciation, which marked the transition between the last glacial and present interglacial periods, was punctuated by a series of rapid (centennial and decadal) climate changes. Numerical climate models are useful for investigating mechanisms that underpin the events, especially now that some of the complex models can be run for multiple millennia. We have set up a Paleoclimate Modelling Intercomparison Project (PMIP) working group to coordinate efforts to run transient simulations of the last deglaciation, and to facilitate the dissemination of expertise between modellers and those engaged with reconstructing the climate of the last 21 thousand years. Here, we present the design of a coordinated Core simulation over the period 21-9 thousand years before present (ka) with time varying orbital forcing, greenhouse gases, ice sheets, and other geographical changes. A choice of two ice sheet reconstructions is given. Additional focussed simulations will also be coordinated on an ad-hoc basis by the working group, for example to investigate the effect of ice sheet and iceberg meltwater, and the uncertainty in other forcings. Some of these focussed simulations will concentrate on shorter durations around specific events to allow the more computationally expensive models to take part. Ivanovic, R. F., Gregoire, L. J., Kageyama, M., Roche, D. M., Valdes, P. J., Burke, A., Drummond, R., Peltier, W. R., and Tarasov, L.: Transient climate simulations of the deglaciation 21-9 thousand years before present; PMIP4 Core experiment design and boundary conditions, Geosci. Model Dev. Discuss., 8, 9045-9102, doi:10.5194/gmdd-8-9045-2015, 2015.

  8. 中国人内源性高甘油三酯血症患者ATP结合盒转运子A1基因R219K多态性研究%Analysis of ATP binding cassette A1 gene R219K polymorphism in patients with endogenous hypertriglyceridemia in Chinese population

    Institute of Scientific and Technical Information of China (English)

    吴银; 白怀; 刘瑞; 刘宇; 刘秉文

    2007-01-01

    目的 研究ATP结合盒转运子A1(ATP binding cassette A1, ABCA1)基因R219K多态性是否与中国人内源性高甘油三酯血症(hypertriglyceridemia, HTG)有关联,为探讨本病的分子遗传基础提供依据.方法 应用聚合酶链反应-限制性片段长度多态性分析法,对成都地区309名汉族人(200名正常人和109例内源性高甘油三酯血症患者)ABCA1基因R219K多态性位点进行分析.结果 中国人ABCA1基因R219K多态位点K等位基因频率在对照组和HTG组分别为0.472与0.436; HTG组和对照组R219K位点之间基因型和等位基因的频率差异无统计学意义.对照组和HTG组KK基因型携带者血清高密度脂蛋白胆固醇(high density lipoprotein-cholesterol, HDL-C)水平均较相应组RR基因型携带者显著升高[(1.48±0.45) mmol/L vs (1.27±0.29) mmol/L, P<0.05;(1.07±0.30) mmol/L vs (0.87±0.19) mmol/L, P<0.05];对照组RK型携带者血清甘油三酯水平较RR型携带者显著降低[(1.22±0.37) mmol/L vs (1.41±0.84) mmol/L, P<0.05],HTG组血清甘油三酯在RR、RK、KK型之间有逐渐降低的趋势[(3.82±2.02) mmol/L vs (3.42±1.67) mmol/L vs (3.33±1.43) mmol/L, P>0.05]; HTG组K等位基因携带者(RK或KK型者)总胆固醇(total cholesterol, TC)/HDL-C比值均较RR型携带者显著降低(KK vs RK vs RR:4.82±1.28 vs 5.42±1.62 vs 6.33±1.70, P<0.05).结论 ABCA1基因R219K多态性不仅与中国成都地区正常汉族人血清HDL-C、甘油三酯含量有关,而且还与内源性高甘油三酯血症患者血清HDL-C水平、TC/HDL-C比值相关联.

  9. Transient climate simulations of the deglaciation 21-9 thousand years before present (version 1) - PMIP4 Core experiment design and boundary conditions

    Science.gov (United States)

    Ivanovic, Ruza F.; Gregoire, Lauren J.; Kageyama, Masa; Roche, Didier M.; Valdes, Paul J.; Burke, Andrea; Drummond, Rosemarie; Peltier, W. Richard; Tarasov, Lev

    2016-07-01

    The last deglaciation, which marked the transition between the last glacial and present interglacial periods, was punctuated by a series of rapid (centennial and decadal) climate changes. Numerical climate models are useful for investigating mechanisms that underpin the climate change events, especially now that some of the complex models can be run for multiple millennia. We have set up a Paleoclimate Modelling Intercomparison Project (PMIP) working group to coordinate efforts to run transient simulations of the last deglaciation, and to facilitate the dissemination of expertise between modellers and those engaged with reconstructing the climate of the last 21 000 years. Here, we present the design of a coordinated Core experiment over the period 21-9 thousand years before present (ka) with time-varying orbital forcing, greenhouse gases, ice sheets and other geographical changes. A choice of two ice sheet reconstructions is given, and we make recommendations for prescribing ice meltwater (or not) in the Core experiment. Additional focussed simulations will also be coordinated on an ad hoc basis by the working group, for example to investigate more thoroughly the effect of ice meltwater on climate system evolution, and to examine the uncertainty in other forcings. Some of these focussed simulations will target shorter durations around specific events in order to understand them in more detail and allow for the more computationally expensive models to take part.

  10. Process for producing astatine-211 for radiopharmaceutical use

    International Nuclear Information System (INIS)

    A one-step chemical manipulation is described in combination with a distillation and collection process for producing At-211 comprising; a. providing a target of irradiated Bismuth coated to a predetermined thickness of a backing member, b. providing a vapor-producing still operably connected with a condenser that has a water cooled condensate collector formed of a dry silica gel mesh maintained at a temperature above the freezing point of water, and providing an effluent gas filter that is operably connected to receive effluent gas from the condenser, c. heating the target in the still at a temperature in the range of about 6300-6800C for a time period in the range of 50 to 80 minutes, to evole At-211 vapor from the target, c. providing a dry carrier gas having an oxygen concentration that is sufficient to form Bi/sub 2/O/sub 3/ thereby to essentially preclude vaporization of Bi metal, passing the carrier gas through the still to carry the At-211 vapor to the condenser, and to carry effluent from the condenser to the effluent gas filter, e. eluting At-211 from the condensate collector of the condenser with a controlled volume of eluent containing predetermined solvents that are compatible with a given desired radiopharmaceutical procedure, and f. collecting the At-211 in the controlled volume of eluent for use in the given radiopharmaceutical procedure

  11. Probabilistic risk assessment: Number 219

    International Nuclear Information System (INIS)

    This report describes a methodology for analyzing the safety of nuclear power plants. A historical overview of plants in the US is provided, and past, present, and future nuclear safety and risk assessment are discussed. A primer on nuclear power plants is provided with a discussion of pressurized water reactors (PWR) and boiling water reactors (BWR) and their operation and containment. Probabilistic Risk Assessment (PRA), utilizing both event-tree and fault-tree analysis, is discussed as a tool in reactor safety, decision making, and communications. (FI)

  12. Evaluation of Adenosine Triphosphate-Binding Cassette Transporter A1 (ABCA1) R219K and C-Reactive Protein Gene (CRP) +1059G/C Gene Polymorphisms in Susceptibility to Coronary Heart Disease.

    Science.gov (United States)

    Li, Jing-Fang; Peng, Dian-Ying; Ling, Mei; Yin, Yong

    2016-01-01

    BACKGROUND This meta-analysis investigated the correlation of ABCA1 R219K and C-Reactive Protein Gene (CRP) +1059G/C gene polymorphisms with susceptibility to coronary heart disease (CHD). MATERIAL AND METHODS We searched PubMed, Springer link, Wiley, EBSCO, Ovid, Wanfang database, VIP database, and China National Knowledge Infrastructure (CNKI) databases to retrieve published studies by keyword. Searches were filtered using our stringent inclusion and exclusion criteria. Resultant high-quality data collected from the final selected studies were analyzed using Comprehensive Meta-analysis 2.0 software. Eleven case-control studies involving 3053 CHD patients and 3403 healthy controls met our inclusion criteria. Seven studies were conducted in Asian populations, 3 studies were done in Caucasian populations, and 1 was in an African population. RESULTS Our major finding was that ABCA1 R219K polymorphism increased susceptibility to CHD in allele model (OR=0.729, 95% CI=0.559~0.949, P=0.019) and dominant model (OR=0.698, 95% CI=0.507~0.961, P=0.027). By contrast, we were unable to find any significant association between the CRP +1059G/C polymorphism and susceptibility to CHD (allele model: OR=1.170, 95% CI=0.782~1.751, P=0.444; dominant model: OR=1.175, 95% CI=0.768~1.797, P=0.457). CONCLUSIONS This meta-analysis provides convincing evidence that polymorphism of ABCA1 R219K is associated with susceptibility to CHD while the CRP +1059G/C polymorphism appears to have no correlation with susceptibility to CHD. PMID:27560308

  13. Evaluation of Adenosine Triphosphate-Binding Cassette Transporter A1 (ABCA1) R219K and C-Reactive Protein Gene (CRP) +1059G/C Gene Polymorphisms in Susceptibility to Coronary Heart Disease

    Science.gov (United States)

    Li, Jing-Fang; Peng, Dian-Ying; Ling, Mei; Yin, Yong

    2016-01-01

    Background This meta-analysis investigated the correlation of ABCA1 R219K and CRP +1059G/C gene polymorphisms with susceptibility to coronary heart disease (CHD). Material/Methods We searched PubMed, Springer link, Wiley, EBSCO, Ovid, Wanfang database, VIP database, and China National Knowledge Infrastructure (CNKI) databases to retrieve published studies by keyword. Searches were filtered using our stringent inclusion and exclusion criteria. Resultant high-quality data collected from the final selected studies were analyzed using Comprehensive Meta-analysis 2.0 software. Eleven case-control studies involving 3053 CHD patients and 3403 healthy controls met our inclusion criteria. Seven studies were conducted in Asian populations, 3 studies were done in Caucasian populations, and 1 was in an African population. Results Our major finding was that ABCA1 R219K polymorphism increased susceptibility to CHD in allele model (OR=0.729, 95% CI=0.559~0.949, P=0.019) and dominant model (OR=0.698, 95% CI=0.507~0.961, P=0.027). By contrast, we were unable to find any significant association between the CRP +1059G/C polymorphism and susceptibility to CHD (allele model: OR=1.170, 95% CI=0.782~1.751, P=0.444; dominant model: OR=1.175, 95% CI=0.768~1.797, P=0.457). Conclusions This meta-analysis provides convincing evidence that polymorphism of ABCA1 R219K is associated with susceptibility to CHD while the CRP +1059G/C polymorphism appears to have no correlation with susceptibility to CHD. PMID:27560308

  14. Development of X80M Steel Gradeφ1 219 mm×33 mm Pipeline Steel Pipe%X80M钢级φ1219 mm×33 mm管线钢管的开发

    Institute of Scientific and Technical Information of China (English)

    张志明; 韩秀林; 姜金星; 武占芳; 刘宏博; 刘鉴卫; 赵彪

    2015-01-01

    通过对X80M钢级Φ1 219 mm×33 mm大壁厚管线钢管千吨级的试制, 总结了大壁厚管线钢管开发的技术特点. 采用超低C, 控Mn, Nb和Ti微合金化成分设计和轻压下、 热机械控制工艺(TMCP)超快冷等工艺控制措施, 国内首次批量开发出了X80M钢级33 mm大壁厚管线钢. 其母材微观组织为细小针状铁素体加弥散粒状贝氏体. 通过制管后检测, 母材及焊缝的拉伸性能、 冲击韧性和止裂性能等完全满足陕京四线工程的要求.%Through kiloton trial production for X80M Φ1 219 mm ×33 mm pipeline steel pipe, it summarized the technical characteristics of line pipe with heavy wall thickness. By the use of ultra-low C, control Mn, Nb, Ti micro-alloying composition design and soft reduction, TMCP ultrafast cold and other control measures, the X80 pipeline steel with 33 mm thickness was developed firstly in China domestic. The microstructure of base metal consists of small timber acicular ferrite and diffuse granular bainite. Through the detection, the tensile properties, impact toughness of base metal and?weld, crack arrest performance fully meet the rigorous requirements of NO.4 Shaanxi Beijing pipeline project.

  15. 36 CFR 219.36 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... conditions and trends of ecosystem composition, structure, and processes are deemed useful for setting objectives for desired conditions and for judging the effectiveness of plan decisions. Responsible official... Policy Act (NEPA) and the Council on Environmental Quality regulations (40 CFR chapter V) as described...

  16. 20 CFR 219.2 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... some other person. Benefit means any employee annuity, spouse annuity, survivor annuity, or lump-sum... proves to the satisfaction of the Board that an individual meets a requirement for eligibility...

  17. 32 CFR 219.102 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... subject's environment that are performed for research purposes. Interaction includes communication or interpersonal contact between investigator and subject. “Private information” includes information...

  18. 36 CFR 219.1 - Purpose.

    Science.gov (United States)

    2010-07-01

    ... continuation of this array of benefits, this regulation affirms sustainability as the overall goal for... management of these lands. (3) Sustainability, composed of interdependent ecological, social, and economic... productivity of the land. Sustainability means meeting needs of the present generation without compromising...

  19. 12 CFR 219.3 - Cost reimbursement.

    Science.gov (United States)

    2010-01-01

    ... financial records pertaining to a customer, by written request, through: (i) A court order; (ii) A subpoena... industry category “Credit Intermediation and Related Activities” (NAICS Code Number 522000) (or successor...” represented by “total benefits” for the “Credit Intermediation and Related Activities” industry...

  20. 32 CFR 219.107 - IRB membership.

    Science.gov (United States)

    2010-07-01

    ... the institution. The IRB shall be sufficiently qualified through the experience and expertise of its members, and the diversity of the members, including consideration of race, gender, and cultural... IRB consists entirely of men or entirely of women, including the institution's consideration...

  1. 36 CFR 219.2 - Principles.

    Science.gov (United States)

    2010-07-01

    ... achievement of goals. (b) Planning contributes to social and economic sustainability by providing for a wide... responsive to a broad range of ecological, social, and economic. (5) Planning acknowledges the limits...

  2. Association between ε2/3/4, Promoter Polymorphism (−491A/T, −427T/C, and −219T/G at the Apolipoprotein E Gene, and Mental Retardation in Children from an Iodine Deficiency Area, China

    Directory of Open Access Journals (Sweden)

    Jun Li

    2014-01-01

    Full Text Available Background. Several common single-nucleotide polymorphisms (SNPs at apolipoprotein E (ApoE have been linked with late onset sporadic Alzheimer’s disease and declining normative cognitive ability in elder people, but we are unclear about their relationship with cognition in children. Results. We studied -491A/T, -427T/C, and -219G/T promoter polymorphisms and ε2/ε3/ε4 at ApoE among children with mental retardation (MR, n=130, borderline MR (n=124, and controls (n=334 from an iodine deficiency area in China. The allelic and genotypic distribution of individual locus did not significantly differ among three groups with Mantel-Haenszel χ2 test (P>0.05. However, frequencies of haplotype of -491A/-427T/-219T/ε4 were distributed as MR > borderline MR > controls (P uncorrected = 0.004, indicating that the presence of this haplotype may increase the risk of disease. Conclusions. In this large population-based study in children, we did not find any significant association between single locus of the four common ApoE polymorphisms (-491A/T, -427T/C, -219T/G, and ε2/3/4 and MR or borderline MR. However, we found that the presence of ATTε4 haplotype was associated with an increased risk of MR and borderline MR. Our present work may help enlarge our knowledge of the cognitive role of ApoE across the lifespan and the mechanisms of human cognition.

  3. Assessment of soil contamination by potentially toxic trace elements (PTSD) (As, Cd, Cu, Hg, Pb, Zn) in a lower plain of the Hron River according to Law no. 219/2008 Coll., by geo-accumulation index, anthropogenic factor and Tomlinson index

    International Nuclear Information System (INIS)

    Soil contamination by different PTSD may have different geogenic and anthropogenic origin and occurs in all countries of the world. The aim of this paper is to evaluate the soils contamination of a lower plain of the Hron River. This paper used the results of the thesis Soil contamination of the Hron River floodplain by trace elements (As, Cd, Cu, Hg, Pb, Zn) [1]. Soil contamination was evaluated by: Act. 219/2008 Coll. on the protection and use of agricultural land, by anthropogenic factor (AF), geo-accumulation index (IgeoE) and Tomlinson index - the index of the pollution load (PLI). (author)

  4. Evaluation of a Wet Chemistry Method for Isolation of Cyclotron Produced [211At]Astatine

    Directory of Open Access Journals (Sweden)

    Shigeki Watanabe

    2013-09-01

    Full Text Available A “wet chemistry” approach for isolation of 211At from an irradiated bismuth target is described. The approach involves five steps: (1 dissolution of bismuth target in conc. HNO3; (2 removal of the HNO3 by distillation; (3 dissolution of residue in 8 M HCl; (4 extraction of 211At from 8 M HCl into DIPE; and (5 extraction of 211At from DIPE into NaOH. Results from 55 “optimized” 211At isolation runs gave recovery yields of approximately 78% after decay and attenuation corrections. An attenuation-corrected average of 26 ± 3 mCi in the target provided isolated (actual yields of 16 ± 3 mCi of 211At. A sixth step, used for purification of 211At from trace metals, was evaluated in seven runs. In those runs, isolated 211At was distilled under reductive conditions to provide an average 71 ± 8% recovery. RadioHPLC analyses of the isolated 211At solutions, both initial and after distillation, were obtained to examine the 211At species present. The primary species of 211At present was astatide, but astatate and unidentified species were also observed. Studies to determine the effect of bismuth attenuation on 211At were conducted to estimate an attenuation factor (~1.33 for adjustment of 211At readings in the bismuth target.

  5. Final Report for grant entitled "Production of Astatine-211 for U.S. Investigators"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, Daniel Scott

    2012-12-12

    Alpha-particle emitting radionuclides hold great promise in the therapy of cancer, but few alpha-emitters are available to investigators to evaluate. Of the alpha-emitters that have properties amenable for use in humans, 211At is of particular interest as it does not have alpha-emitting daughter radionuclides. Thus, there is a high interest in having a source of 211At for sale to investigators in the US. Production of 211At is accomplished on a cyclotron using an alpha-particle beam irradiation of bismuth metal. Unfortunately, there are few cyclotrons available that can produce an alpha particle beam for that production. The University of Washington has a cyclotron, one of three in the U.S., that is currently producing 211At. In the proposed studies, the things necessary for production and shipment of 211At to other investigators will be put into place at UW. Of major importance is the efficient production and isolation of 211At in a form that can be readily used by other investigators. In the studies, production of 211At on the UW cyclotron will be optimized by determining the best beam energy and the highest beam current to maximize 211At production. As it would be very difficult for most investigators to isolate the 211At from the irradiated target, the 211At-isolation process will be optimized and automated to more safely and efficiently obtain the 211At for shipment. Additional tasks to make the 211At available for distribution include obtaining appropriate shipping vials and containers, putting into place the requisite standard operating procedures for Radiation Safety compliance at the levels of 211At activity to be produced / shipped, and working with the Department of Energy, Isotope Development and Production for Research and Applications Program, to take orders, make shipments and be reimbursed for costs of production and shipment.

  6. Astatination of nanoparticles containing silver as possible carriers of 211At

    Czech Academy of Sciences Publication Activity Database

    Lebeda, Ondřej; Kučka, Jan; Hrubý, Martin; Koňák, Čestmír; Kozempel, Ján

    2006-01-01

    Roč. 64, - (2006), s. 201-206. ISSN 0969-8043 R&D Projects: GA AV ČR KJB4048302; GA AV ČR KJB4050408 Institutional research plan: CEZ:AV0Z1048901 Keywords : nanoparticles * 211AT * Atalpha particle therapy Subject RIV: CH - Nuclear ; Quantum Chemistry Impact factor: 0.924, year: 2006

  7. Production of Astatine-211 at the Duke University Medical Center for its regional distribution

    Energy Technology Data Exchange (ETDEWEB)

    Zalutsky, Michael [Duke University Medical Center, Durham, NC (United States)

    2016-01-01

    Systemic targeted radiation therapy and radioimmunotherapy continue to be important tools in the treatment of certain cancers. Because of their high energy and short path length, alpha particle emitters such as 211At are more effective than either external beam x- ray or in vivo beta radiation in delivering potentially curative doses of radiation. The limited clinical trials that have been conducted to date have yielded encouraging responses in some patients, e.g., malignant brain tumors. In order to escalate the additional necessary research and development in radiochemistry, radiobiology and efficacy evaluation of alpha particle radiotherapeutics, it is universally agreed that access to an affordable, reliable supply of 211At is warranted. In conjunction with the Department of Energy's intent to enhance stable and radioactive isotope availability for research applications, it is the primary objective of this project to improve 211At production and purification capabilities at Duke so that this radionuclide can be supplied to researchers at other institutions throughout the US.The most widely used 211At production method involves the α,2n reaction on Bismuth using a cyclotron with beams ≤ 28 MeV. Yields can be enhanced with use of an internal target that allows for a higher alpha fluence plus efficient heat dissipation in the target. Both of these items are in place at Duke; however, in order to support production for multi-institutional use, irradiation campaigns in excess of 50 µAp and four hours duration will be needed. Further, post-irradiation processing equipment is lacking that will enable the distribution process. Financial support is sought for i) a shielded, ventilated processing/containment hood; ii) development of a post-irradiation target retrieval system; iii) fabrication of a 211At distillation and recovery module and iv) a performance review and, where needed, an enhancement of seven major subsystems that comprise the CS-30 Cyclotron. With these modifications in place, routine production of ≥200 mCi of At-211 should be readily achievable, given our methodological development of At-211 target preparation, internal target irradiation and dry distillation to recover the radionuclide.

  8. Investigation on the Full Thickness Repair Welding Process of X80Mφ1 219 mm×18.4 mm SAWH Pipe%X80M级准1219 mm×18.4 mm螺旋埋弧焊管全壁厚补焊工艺研究

    Institute of Scientific and Technical Information of China (English)

    杨军; 苟世峰; 符利兵; 陈长青

    2015-01-01

    利用夏比冲击、显微硬度和拉伸试验对6种焊材在相同补焊工艺下的全壁厚刨透补焊焊缝进行了性能对比研究,筛选出焊缝性能较优的对应补焊焊材。并以此焊材作为X80M级φ1219 mm ×18.4 mm螺旋埋弧焊管焊缝缺陷手工修补用专用焊材,进行了不同补焊工艺参数的全壁厚刨透补焊试验,并对补焊焊缝进行低温冲击试验,通过比较确定出X80M级φ1219 mm×18.4 mm螺旋埋弧焊管全壁厚刨透补焊工艺方案。结果表明,上海焊接器材厂生产的SH J557焊条用于X80M级φ1219 mm×18.4 mm螺旋埋弧焊管焊缝缺陷全壁厚刨透手工修补更为合适,各项性能指标更高;确定的补焊工艺参数合理可行,确保了补焊焊缝的质量和钢管的批量化生产。%The properties of full thickness repair welding seam that generated by 6 kinds of welding material under the same repair welding condition were comparatively investigated by V-notch Charpy impact toughness test, micro-hardness test and tensile test, and selected out the repair welding material matching with better weld performance. Taking the selected welding material as special welding material for manual repairing the weld defect in φ1 219 mm ×18.4 mm X80M SAWH pipe, the full thickness repair welding tests for the different welding process parameter were conducted, and the low temperature impact test for repair weld was carried out. Finally, it determined the repair welding process for φ1 219 mm×18.4 mm X80M SAWH pipe. The results indicated that the SHJ557 welding electrode produced by Shanghai Welding Equipment Factory is more suitable for the above repair welding process of φ1 219 mm ×18.4 mm X80M SAWH pipe, the various performance indexes are higher; the determined repair welding process parameters are reasonable, it ensures the quality of repair weld and the mass production of steel pipe.

  9. Dicty_cDB: CHM219 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available rkl*s*attnigngfeirtlfnelfll**trkcfrekrrnr*c*s l*vykirfw*kngvkireil*se*rkkipskkikpikti*v*...LYKTKNSINTLTFVDERRDKFFGKESRQEDKIAEQKLIAIS AGVKE--- ---*rdihniy*rekkiiilsnhkywkrirdpnii**iifiiinskmf*rkkke*mmlkf isl*n*ilvkk...yghhmd*qyihiwdyhy*iqyyyyyleqy*qmviqy*pnkkr ymkrtkky*q*kkhlki**iyikqktv*ih*pl*mkeetnflekkvdkrtrlqnkn**qy qqe*k--- ---tretftifikek...rtksg t*kerksissrrsi*kfnefi*nkkqykyinlcr*kkrqifwkrk*trgqdcrtkinsni srskr--- ---LERHSQYLLKRKENYNPKQPQIL...0 m3a: 0.00 m3b: 0.00 m_ : 0.00 36.0 %: extracellular, including cell wall 32.0 %: plasma membrane 20.0 %: endoplasmic re

  10. Dicty_cDB: VHM219 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available NNNNN Length of 5' end seq. 620 3' end seq. ID - 3' end seq. - Length of 3' end seq. - Connect...ed seq. ID - Connected seq. - Length of connected seq. - Full length Seq ID - Full length Seq. - Length of full length seq. - ... ...skrsf*nk*f*ism ftfnnnlihwfkcnihyshaillnpnwldvngclsywfngnw**lys*nffkesis*fny wnncnvtivis...) Oryza sativa Japonica Group genom... 109 5e-23 U09503_1( U09503 |pid:none) Arabidopsis thaliana Co...lumbia chloropl... 108 9e-23 AF229392_1( AF229392 |pid:none) Arabidopsis thaliana cultivar Colu... 1

  11. 29 CFR 1910.219 - Mechanical power-transmission apparatus.

    Science.gov (United States)

    2010-07-01

    ... described in paragraph (o)(5) of this section. (3) Tail rods or extension piston rods. Tail rods or extension piston rods shall be guarded in accordance with paragraphs (m) and (o) of this section, or by a... when rod is fully extended. (c) Shafting—(1) Installation. (i) Each continuous line of shafting...

  12. Dicty_cDB: VFA219 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available N BD092935 |BD092935.1 Methods and compositions for synthesis of long chain poly...unsaturated fatty acids in plants. 1213 0.0 3 BD082645 |BD082645.1 Methods and compositions for synthesis of... long chain polyunsaturated fatty acids. 1213 0.0 3 BD082630 |BD082630.1 Methods and compositions for synthe

  13. 24 CFR 884.219 - Overcrowded and underoccupied units.

    Science.gov (United States)

    2010-04-01

    ... Contract unit is larger than appropriate for the size of the Family in occupancy, housing assistance payments with respect to such unit will not be abated, unless the Owner fails to offer the Family a... reasonable time, HUD (or the PHA) will assist the Family in finding a suitable dwelling unit and require...

  14. 49 CFR 219.203 - Responsibilities of railroads and employees.

    Science.gov (United States)

    2010-10-01

    ... duty tour. An employee who has been transported to receive medical care is not released from duty for... testing does not excuse such refusal by the employee timely to provide the required specimens. (c)...

  15. 48 CFR 52.219-1 - Small Business Program Representations.

    Science.gov (United States)

    2010-10-01

    ... check the category in which its ownership falls: __ Black American. __ Hispanic American. __ Native American (American Indians, Eskimos, Aleuts, or Native Hawaiians). __ Asian-Pacific American (persons with... provision: Small Business Program Representations (MAY 2004) (a)(1) The North American...

  16. Dicty_cDB: VSF219 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 0.009 2 BU042820 |BU042820.1 PP_LEa0014B11f Peach developing fruit mesocarp Prunus persica cDNA clone PP_LE...a0014B11f, mRNA sequence. 52 0.010 1 BU041769 |BU041769.1 PP_LEa0010G24f Peach developing...32.1 PP_LEa0019F12f Peach developing fruit mesocarp Prunus persica cDNA clone PP_LEa0019F12f, mRNA sequence.

  17. 47 CFR 90.219 - Use of signal boosters.

    Science.gov (United States)

    2010-10-01

    ... fill in only weak signal areas and cannot extend the system's normal signal coverage area. (b) Class A... effective radiated power (ERP) of the unit to a maximum of 5 watts under all conditions. Class B broadband signal boosters are limited to 5 watts ERP for each authorized frequency that the booster is designed...

  18. 49 CFR 219.601 - Railroad random drug testing programs.

    Science.gov (United States)

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Random Alcohol and Drug Testing... be selected as the result of the exercise of discretion by the railroad. The selection method must...

  19. 20 CFR 725.219 - Duration of entitlement; child.

    Science.gov (United States)

    2010-04-01

    ...; (3) The child attains age 18; and (i) Is not a student (as defined in § 725.209(b)) during any part of the month in which the child attains age 18; and (ii) Is not under a disability (as defined in § 725.209(a)(2)(ii)) at that time; (4) If the child's entitlement beyond age 18 is based on his or...

  20. 36 CFR 219.4 - Identification and consideration of issues.

    Science.gov (United States)

    2010-07-01

    ... AGRICULTURE PLANNING National Forest System Land and Resource Management Planning The Framework for Planning... interested in or affected by National Forest System management; Presidential, Departmental, and Forest Service conservation leadership initiatives; cooperatively developed landscape goals (§...

  1. 49 CFR 219.9 - Responsibility for compliance.

    Science.gov (United States)

    2010-10-01

    .... (a) Any person (an entity of any type covered under 1 U.S.C. 1, including but not limited to the... the standard of liability for a railroad will vary depending upon the requirement involved. See, e.g...) Any independent contractor or other entity that performs covered service for a railroad has the...

  2. 34 CFR 685.219 - Public Service Loan Forgiveness Program.

    Science.gov (United States)

    2010-07-01

    ... organization that is publicly funded and whose principal activities pertain to crime prevention, control or reduction of crime, or the enforcement of criminal law. Military service, for uniformed members of the U.S... library or other school-based services; and (ii) Is not a business organized for profit, a labor union,...

  3. 48 CFR 52.219-9 - Small business subcontracting plan.

    Science.gov (United States)

    2010-10-01

    ... business, and women-owned small business concerns. If the offeror is submitting an individual contract plan... women-owned small business concerns, with a separate part for the basic contract and separate parts for... of this contract entitled “Utilization of Small Business Concerns” in all subcontracts that...

  4. Research and Development of X80 Grade SAWH Pipe with Size of φ1 219 mm×22.0 mm%X80级准1219 mm×22.0 mm螺旋埋弧焊管的研制

    Institute of Scientific and Technical Information of China (English)

    陈楠; 孙志刚; 李建一; 孙少卿; 祁超; 王海生

    2015-01-01

    The X80 grade hot-rolled coil with large wall thickness was manufactured by using the technology of low carbon, high manganese, Nb-Mo compound additive, micro alloying, clean smelting, controlled rolling and controlled cooling. Through research on steel pipe low tress forming technology, welding speed optimization, double rack ultrasonic testing technology, the X80 grade SAWH pipe with size of φ1 219 mm×22.0 mm was developed. The property tests were conducted in accordance with relevant technical standard. The test results showed that the transverse yield strength of pipe body is 580~670 MPa;the tensile strength is 665~770 MPa;the tensile strength of weld seam is 695~760 MPa;the hardness of welded joint is less than 268 HV10 Under-10℃,the average impact energy of pipe body in transverse is higher than 319 J;the average impact energy of HAZ is higher than 183 J, and the average impact energy of weld seam is higher than 137 J. Under 0℃,the DWTT shear area of pipe body in transverse is 100%. The pipe is with good mechanical properties and weldability.%采用低C高Mn及Nb-Mo复合添加、微合金化设计和洁净化冶炼、控轧控冷工艺制造的X80级大壁厚热轧卷板,通过钢管低应力成型、焊接速度优选以及双探架超声波检测等技术,成功开发出X80级准1219 mm×22.0 mm螺旋埋弧焊管。按标准要求对该产品进行了组批力学性能试验,试验结果显示:钢管管体横向屈服强度为580~670 MPa,抗拉强度为665~770 MPa,焊缝抗拉强度为695~760 MPa;焊接接头最大硬度小于268 HV10;-10℃管体横向平均冲击功大于319 J,热影响区平均冲击功大于183 J,焊缝平均冲击功大于137 J;0℃管体横向DWTT剪切面积均为100%。试验结果表明,钢管整体具有良好的力学性能和可焊性。

  5. Astatine-211 conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model

    Energy Technology Data Exchange (ETDEWEB)

    Green, Damian J.; Shadman, Mazyar; Jones, Jon C.; Frayo, Shani; Kenoyer, Aimee L.; Hylarides, Mark; Hamlin, Donald K.; Wilbur, D. Scott; Balkan, Ethan R.; Lin, Yukang; Miller, Brian W.; Frost, Sophia; Gopal, Ajay K.; Orozco, Johnnie J.; Gooley, Ted; Laird, Kelley L.; Till, B. G.; Back, Tom; Sandmaier, B. M.; Pagel, John M.; Press, Oliver W.

    2015-03-26

    Alpha emitting radionuclides release a large amount of energy within a few cell diameters and may be particularly effective for radioimmunotherapy targeting minimal residual disease (MRD) conditions in which micrometastatic disease satellites are broadly distributed. To evaluate this hypothesis, 211At conjugated 1F5 mAb (anti-CD20) was studied in both bulky lymphoma tumor xenograft and MRD animal models. Superior treatment responses to 211At conjugated 1F5 mAb were evident in the MRD setting. Lymphoma xenograft tumor bearing animals treated with doses of up to 48µCi of anti-CD20 211At-decaborate [211At-B10-1F5] experienced modest responses (0% cures but 2-3-fold prolongation of survival compared to negative controls). In contrast, 70% of animals in the MRD lymphoma model demonstrated complete eradication of disease when treated with 211At-B10-1F5 at a radiation dose that was less than one-third (15 µCi) of the highest dose given to xenograft animals. Tumor progression among untreated control animals in both models was uniformly lethal. After 130 days, no significant renal or hepatic toxicity is observed in the cured animals receiving 15 µCi of 211At-B10-1F5. These findings suggest that in a MRD lymphoma model, where isolated cells and tumor microclusters prevail, α-emitters may be uniquely efficacious.

  6. An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE,CERN

    OpenAIRE

    Rothe, Sebastian

    2012-01-01

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spec...

  7. Inactivation of human osteosarcoma cells in vitro by {sup 211}At-TP-3 monoclonal antibody: Comparison with astatine-211 and external-beam X rays

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, R.H. [Univ. of Oslo (Norway)]|[Institute for Cancer Research, Oslo (Norway); Bruland, O.S. [Institute for Cancer Research, Oslo (Norway); Hoff, P.; Alstad, J. [Univ. of Oslo (Norway); Lindmo, T. [Institute for Cancer Research, Oslo (Norway); Rofstad, E.K. [Norwegian Institute of Technology, Trondheim (Norway)

    1994-08-01

    The potential usefulness of {alpha}-particle radioimmunotherapy in the treatment of osteosarcoma was studied in vitro by using the monoclonal antibody TP-3 and cells of three human osteosarcoma cell lines (OHS, SAOS and KPDX) differing in antigen expression. Cell survival curves were established after treatment with (a) {sup 211}At-TP-3 of different specific activities, (b) {sup 211}At-labeled bovine serum albumin (BSA), (c) free {sup 211}At and (d) external-beam X rays. The three osteosarcoma cell lines showed similar survival curves, whether treated with external-beam X rays, {sup 211}At-BSA or free {sup 211}At. The D{sub o}`s were lower for free {sup 211}At than for {sup 211}At-BSA. The survival curves for {sup 211}At-TP-3 treatment, on the other hand, differed significantly among the cell lines, suggesting that sensitivity to {sup 211}At-TP-3 treatment was governed by cellular properties other than sensitivity to external-beam X rays. The cellular property most important for sensitivity to {sup 211}At-TP-3 treatment was the antigen expression. Cell inactivation after {sup 211}At-TP-3 treatment increased substantially with increasing specific activity of the {sup 211}At-TP-3. At high specific activities, the cytotoxic effect of {sup 211}At-TP-3 was significantly higher than that of {sup 211}At-BSA. In conclusion, {sup 211}At-TP-3 has the potential to give clinically favorable therapeutic ratios in the treatment of osteosarcoma. 39 refs., 5 figs., 2 tabs.

  8. Polychlorinated biphenyls (PCB) analysis report for solid sample for 219S tank 102

    International Nuclear Information System (INIS)

    One waste sample was analyzed (with duplicate, matrix spike, and matrix spike duplicate) for PCBs as Aroclor mixtures by the Inorganic/Organic Chemistry Group. A soxhlet extraction procedure was used for extraction of the Aroclors from the sample. Analysis was performed using dual column confirmation gas chromatography/electron capture detection (GC/ECD). Extraction follows closely method 354 C of SW-846, analysis follows SW-846 method 8082. A cross reference of laboratory sample number to the customer identification is given in a table

  9. Calibration of ground-based lidar instrument WLS7-219

    DEFF Research Database (Denmark)

    Gómez Arranz, Paula; Wagner, Rozenn

    This report presents the result of the lidar calibration performed for the given WLS7 Windcube at DTU’s test site for large wind turbine at Høvsøre, Denmark. Calibration is here understood as the establishment of a relation between the reference wind speed measurements with measurement...... uncertainties provided by measurement standard and corresponding lidar wind speed indications with associated measurement uncertainties. The lidar calibration concerns the 10 minute mean wind speed measurements. The comparison of the lidar measurements of the wind direction with that from wind vanes...... measurements are given for information only....

  10. Calibration of ground-based Lidar instrument WLS7-219

    DEFF Research Database (Denmark)

    Yordanova, Ginka; Gómez Arranz, Paula

    This report presents the result of the lidar calibration performed for the given WLS7 Windcube at DTU’s test site for large wind turbines at Høvsøre, Denmark. Calibration is here understood as the establishment of a relation between the reference wind speed measurements with measurement...... uncertainties provided by measurement standard and corresponding lidar wind speed indications with associated measurement uncertainties. The lidar calibration concerns the 10 minute mean wind speed measurements. The comparison of the lidar measurements of the wind direction with that from wind vanes...... measurements are given for information only....

  11. 49 CFR 219.201 - Events for which testing is required.

    Science.gov (United States)

    2010-10-01

    ... conveyance at a rail/highway grade crossing. No test may be required in the case of an accident/incident the... physical damage be specifically described. (2) A railroad must not require an employee to provide blood...

  12. 7 CFR 2.19 - Under Secretary for Food, Nutrition, and Consumer Services.

    Science.gov (United States)

    2010-01-01

    ... responsibilities. (vi) Serve as a consumer ombudsman and communication link between consumers and the Department... costs for use as standards by families of different sizes, sex-age composition, and economic...

  13. 28 CFR 2.219 - Maximum terms of imprisonment and supervised release.

    Science.gov (United States)

    2010-07-01

    .... 22-2105 Manslaughter 5 years 3 years. 22-2105, 4502 Manslaughter: armed * 5 years 5 years. 22-2201(e... degree 5 years 5 years. Manslaughter 5 years 5 years. Kidnapping 5 years 5 years. Assault with intent to... enforcement officer, second degree murder, manslaughter, kidnapping 5 years 3 years. Attempt/conspiracy...

  14. 2-[1-(9-Anthrylmethyl-1H-pyrazol-3-yl]pyridine

    Directory of Open Access Journals (Sweden)

    Shi-Lu Zhang

    2009-11-01

    Full Text Available The title compound, C23H17N3, can be used in coordination chemistry. The anthracene ring makes dihedral angles of 86.08 (5 and 76.63 (6°, respectively, with the pyridine and pyrazole rings. The dihedral angle between the pyrazole and pyrimidine rings is 11.79 (7°. In the structure, weak intermolecular C—H...N hydrogen bonds are observed.

  15. 20 CFR 219.37 - Evidence of natural parent or child relationship.

    Science.gov (United States)

    2010-04-01

    ... copy of the child's public or religious birth record. (b) Other evidence of parent or child... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Evidence of natural parent or child... parent or child relationship. (a) Preferred evidence. If the claimant is the natural parent of...

  16. 20 CFR 219.34 - When evidence that a marriage has ended is required.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false When evidence that a marriage has ended is... a marriage has ended is required. Evidence of how a previous marriage ended may be required to determine whether a later marriage is valid. If a widow or widower remarried after the employee's death...

  17. SUBTASK 2.19 – OPERATIONAL FLEXIBILITY OF CO2 TRANSPORT AND STORAGE

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, Melanie; Schlasner, Steven; Sorensen, James; Hamling, John

    2014-12-31

    Carbon dioxide (CO2) is produced in large quantities during electricity generation and by industrial processes. These CO2 streams vary in terms of both composition and mass flow rate, sometimes substantially. The impact of a varying CO2 stream on pipeline and storage operation is not fully understood in terms of either operability or infrastructure robustness. This study was performed to summarize basic background from the literature on the topic of operational flexibility of CO2 transport and storage, but the primary focus was on compiling real-world lessons learned about flexible operation of CO2 pipelines and storage from both large-scale field demonstrations and commercial operating experience. Modeling and pilot-scale results of research in this area were included to illustrate some of the questions that exist relative to operation of carbon capture and storage (CCS) projects with variable CO2 streams. It is hoped that this report’s real-world findings provide readers with useful information on the topic of transport and storage of variable CO2 streams. The real-world results were obtained from two sources. The first source consisted of five full-scale, commercial transport–storage projects: Sleipner, Snøhvit, In Salah, Weyburn, and Illinois Basin–Decatur. These scenarios were reviewed to determine the information that is available about CO2 stream variability/intermittency on these demonstration-scale projects. The five projects all experienced mass flow variability or an interruption in flow. In each case, pipeline and/or injection engineers were able to accommodate any issues that arose. Significant variability in composition has not been an issue at these five sites. The second source of real- world results was telephone interviews conducted with experts in CO2 pipeline transport, injection, and storage during which commercial anecdotal information was acquired to augment that found during the literature search of the five full-scale projects. The experts represented a range of disciplines and hailed from North America and Europe. Major findings of the study are that compression and transport of CO2 for enhanced oil recovery (EOR) purposes in the United States has shown that impurities are not likely to cause transport problems if CO2 stream composition standards are maintained and pressures are kept at 10.3 MPa or higher. Cyclic, or otherwise intermittent, CO2 supplies historically have not impacted in-field distribution pipeline networks, wellbore integrity, or reservoir conditions. The U.S. EOR industry has demonstrated that it is possible to adapt to variability and intermittency in CO2 supply through flexible operation of the pipeline and geologic storage facility. This CO2 transport and injection experience represents knowledge that can be applied in future CCS projects. A number of gaps in knowledge were identified that may benefit from future research and development, further enhancing the possibility for widespread application of CCS. This project was funded through the Energy & Environmental Research Center–U.S. Department of Energy Joint Program on Research and Development for Fossil Energy-Related Resources Cooperative Agreement No. DE-FC26-08NT43291. Nonfederal funding was provided by the IEA Greenhouse Gas R&D Programme.

  18. 20 CFR 219.55 - Evidence of school attendance for child age 18.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Evidence of school attendance for child age... school attendance for child age 18. The child will be asked to submit (on a form furnished by the Board... statement from an official of the school verifying that the child is attending school full-time. The...

  19. 48 CFR 52.219-3 - Notice of total HUBZone set-aside.

    Science.gov (United States)

    2010-10-01

    ... business concerns. (d) A HUBZone joint venture agrees that, in the performance of the contract, the... percent of the cost of personnel for contract performance will be spent for employees of the concern or... nonmanufacturer of the supplies), at least 50 percent of the cost of manufacturing, excluding the cost...

  20. 14 CFR 125.219 - Oxygen for medical use by passengers.

    Science.gov (United States)

    2010-01-01

    ... title 49 CFR parts 171, 172, and 173, except § 173.24(a)(1); (ii) When owned by the certificate holder... the form of a compressed gas as defined in title 49 CFR 173.300(a)— (i) When owned by the certificate... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Oxygen for medical use by passengers....

  1. 48 CFR 52.219-25 - Small Disadvantaged Business Participation Program-Disadvantaged Status and Reporting.

    Science.gov (United States)

    2010-10-01

    ...) (a) Disadvantaged status for joint venture partners, team members, and subcontractors. This clause addresses disadvantaged status for joint venture partners, teaming arrangement members, and subcontractors.... The Contractor shall obtain representations of small disadvantaged status from joint venture...

  2. 25 CFR 166.219 - How do I acquire a permit through negotiation?

    Science.gov (United States)

    2010-04-01

    ... arrangement, the permit may be granted to a joint venture or other legal entity owned, in part, by the Indian... the Indian landowner a partner, joint venturer, or associate of the permittees. (e) We will...

  3. 32 CFR 219.101 - To what does this policy apply?

    Science.gov (United States)

    2010-07-01

    ..., subpart C. The exemption at 45 CFR 46.101(b)(2), for research involving survey or interview procedures or... tests (cognitive, diagnostic, aptitude, achievement), survey procedures, interview procedures, or... assurances on file will abide by provisions of title 45 CFR part 46 subparts A-D. Some of the...

  4. 48 CFR 52.219-6 - Notice of Total Small Business Set-Aside.

    Science.gov (United States)

    2010-10-01

    ... following clause: Notice of Total Small Business Set-Aside (JUN 2003) (a) Definition. Small business concern... business concerns and Federal Prison Industries, Inc. (FPI). Offers received from concerns that are...

  5. 48 CFR 52.219-18 - Notification of Competition Limited to Eligible 8(a) Concerns.

    Science.gov (United States)

    2010-10-01

    ... made to the Small Business Administration, which will subcontract performance to the successful 8(a... that there are no small business manufacturers or processors in the Federal market in accordance with... of its stock or other ownership interest to any other party. (End of clause) Alternate I (APR...

  6. 14 CFR 120.219 - Handling of test results, record retention, and confidentiality.

    Science.gov (United States)

    2010-01-01

    ... requirement. In addition to the records required to be maintained under 49 CFR part 40, employers must..., you must use the Management Information System (MIS) form and instructions as required by 49 CFR part 40 (at 49 CFR 40.26 and appendix H to 49 CFR part 40). You may also use the electronic version of...

  7. Muon scattering at 219 GeV and the proton structure functions

    International Nuclear Information System (INIS)

    Results on the proton structure function, F2, are presented for 0.3 2 2 and 10 < v < 200 GeV. The results support the conclusions of earlier work at 97 and 147 GeV that scaling is violated. A new value for R = sigma/sub s//sigma/sub T/ = 0.44 +- 0.25 has been obtained using all the Fermilab proton measurements

  8. 48 CFR 252.219-7004 - Small business subcontracting plan (test program).

    Science.gov (United States)

    2010-10-01

    ... Subcontracting Plan (Test Program) (AUG 2008) (a) Definition. Subcontract, as used in this clause, means any... Contractor shall submit Standard Form (SF) 295, Summary Subcontract Report, in accordance with the... completed to include semi-annual cumulative— (i) Small business, small disadvantaged business, and...

  9. 36 CFR 219.16 - Relationships with interested individuals and organizations.

    Science.gov (United States)

    2010-07-01

    ..., DEPARTMENT OF AGRICULTURE PLANNING National Forest System Land and Resource Management Planning Collaborative... individuals and organizations to work collaboratively with one another to improve understanding and...

  10. Yeast Interacting Proteins Database: YPL031C, YPL219W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available ting the cellular response to nutrient levels and environmental conditions and progression through the cell ...e cellular response to nutrient levels and environmental conditions and progression through the cell cycle R

  11. 29 CFR 778.219 - Pay for foregoing holidays and vacations.

    Science.gov (United States)

    2010-07-01

    ... principle: (1) An employee whose rate of pay is $5 an hour and who usually works a 6-day 48-hour week is... earnings—$240. He foregoes his vacation and works 50 hours in the week in question. He is owed $250 as his... day. During the entire week he works a total of 50 hours. He is paid under his contract, $250...

  12. Codon 219 polymorphism of PRNP in healthy caucasians and Creutzfeldt-Jakob disease patients

    Energy Technology Data Exchange (ETDEWEB)

    Petraroli, R.; Pocchiari, M. [Instituto Superiore di Sanita, Rome (Italy)

    1996-04-01

    A number of point and insert mutations of the PrP gene (PRNP) have been linked to familial Creutzfeldt-Jakob disease (CJD) and Gerstmann-Straussler-Scheinker disease (GSS). Moreover, the methionine/valine homozygosity at the polymorphic codon 129 of PRNP may cause a predisposition to sporadic and iatrogenic CJD or may control the age at onset of familial cases carrying either the 144-bp insertion or codon 178, codon 198, and codon 210 pathogenic mutations in PRNP. In addition, the association of methionine or valine at codon 129 and the point mutation at codon 178 on the same allele seem to play an important role in determining either fatal familial insomnia or CJD. However, it is noteworthy that a relationship between codon 129 polymorphism and accelerated pathogenesis (early age at onset or shorter duration of the disease) has not been seen in familial CJD patients with codon 200 mutation or in GSS patients with codon 102 mutation, arguing that other, as yet unidentified, gene products or environmental factors, or both, may influence the clinical expression of these diseases. 17 refs.

  13. Low background counting of 222Rn, 220Rn and 219Rn with electrostatic counters

    Science.gov (United States)

    Mong, Brian; EXO-200 Collaboration; nEXO Collaboration

    2014-09-01

    The radon counting technique based on electrostatic precipitation of progenies in gas followed by alpha spectroscopy has been applied to support the material selection programs of low background, neutrino and dark matter experiments with emphasis on EXO. An array of 8 counters operated by Laurentian University at SNOLAB and the Waste Isolation Pilot Plant have reached the sensitivity of 10 atoms/day in the uranium, thorium and actinium chains. Hardware improvements are underway to further increase the capacity and sensitivity in support of nEXO. The radon counting technique based on electrostatic precipitation of progenies in gas followed by alpha spectroscopy has been applied to support the material selection programs of low background, neutrino and dark matter experiments with emphasis on EXO. An array of 8 counters operated by Laurentian University at SNOLAB and the Waste Isolation Pilot Plant have reached the sensitivity of 10 atoms/day in the uranium, thorium and actinium chains. Hardware improvements are underway to further increase the capacity and sensitivity in support of nEXO. Supported by NSERC Project Grants ``Search for Double Beta Decay with EXO.''

  14. La Desercion Escolar en los Niveles de Sexto y Noveno Grado: Una Comparacion Entre Zonas Rurales y Urbanas. Boletin 219 (The Educational Desertion in the 6th and 9th Grades: A Comparison Between Rural and Urban Zones. Bulletin 219).

    Science.gov (United States)

    Lopez, Maria I. Hernandez; And Others

    In 1962 and again in 1965, a group of sixth and ninth grade students in selected schools in four Puerto Rican communities were interviewed to investigate the factors influencing students' decision to withdraw from school before completing twelfth grade and to identify some characteristics of dropouts. Of 616 students interviewed in 1962, 20.9% of…

  15. Crystallization and preliminary crystallographic analysis of the catechol 2,3-dioxygenase PheB from Bacillus stearothermophilus BR219

    International Nuclear Information System (INIS)

    PheB, an extradiol-cleaving catecholic dioxygenase, was crystallized by the hanging-drop vapour-diffusion method using PEG 4000 as a precipitant. The crystal belongs to the orthorhombic system, space group P212121, and diffracts to 2.3 Å resolution. Class II extradiol-cleaving catecholic dioxygenase, a key enzyme of aromatic compound degradation in bacteria, cleaves the aromatic ring of catechol by adding two O atoms. PheB is one of the class II extradiol-cleaving catecholic dioxygenases and shows a high substrate specificity for catechol derivatives, which have one aromatic ring. In order to reveal the mechanism of the substrate specificity of PheB, PheB has been crystallized by the hanging-drop vapour-diffusion method using PEG 4000 as a precipitant. The space group of the obtained crystal was P212121, with unit-cell parameters a = 65.5, b = 119.2, c = 158.7 Å. The crystal diffracted to 2.3 Å resolution

  16. 32 CFR 219.103 - Assuring compliance with this policy-research conducted or supported by any Federal Department or...

    Science.gov (United States)

    2010-07-01

    ... capacity; indications of experience such as board certifications, licenses, etc., sufficient to describe..., member of governing panel or board, stockholder, paid or unpaid consultant. Changes in IRB membership..., and for which provisions are made for meeting space and sufficient staff to support the IRB's...

  17. Lithium-vanadium advanced blanket development. ITER final report on U.S. contribution: Task T219/T220

    International Nuclear Information System (INIS)

    The objective of this task is to develop the required data base and demonstrate the performance of a liquid lithium-vanadium advanced blanket design. The task has two main activities related to vanadium structural material and liquid lithium system developments. The vanadium alloy development activity included four subtasks: (1.1) baseline mechanical properties of non irradiated base metal and weld metal joints; (1.2) compatibility with liquid lithium; (1.3) material irradiation tests; and (1.4) development of material manufacturing and joining methods. The lithium blanket technology activity included four subtasks: (2.1) electrical insulation development and testing for liquid metal systems; (2.2) MHD pressure drop and heat transfer study for self-cooled liquid metal systems; (2.3) chemistry of liquid lithium; and (2.4) design, fabrication and testing of ITER relevant size blanket mockups. A summary of the progress and results obtained during the period 1995 and 1996 in each of the subtask areas is presented in this report

  18. 76 FR 16526 - Airworthiness Directives; Pratt & Whitney JT8D-209, -217, -217A, -217C, and -219 Series Turbofan...

    Science.gov (United States)

    2011-03-24

    .../stage 4 LPT turbine blades shroud wear and subsequent high-cycle fatigue. They suggested that the... stage and 4th stage low- pressure turbine (LPT) blades for shroud notch wear and replacement of the... prevent turbine blade failures that could result in uncontained engine debris and damage to the...

  19. 75 FR 56533 - Wireless Telecommunications Bureau Postpones Auction of 218-219 MHz Service and Phase II 220 MHz...

    Science.gov (United States)

    2010-09-16

    ... document announces the postponement of Auction 89. FOR FURTHER INFORMATION CONTACT: Wireless.... SUPPLEMENTARY INFORMATION: This is a summary of the Auction 89 Postponement Public Notice, which was released on August 26, 2010. The complete text of the Auction 89 Postponement Public Notice and related...

  20. Lithium-vanadium advanced blanket development. ITER final report on U.S. contribution: Task T219/T220

    Energy Technology Data Exchange (ETDEWEB)

    Smith, D.L.; Mattas, R.F. [comps.

    1997-07-01

    The objective of this task is to develop the required data base and demonstrate the performance of a liquid lithium-vanadium advanced blanket design. The task has two main activities related to vanadium structural material and liquid lithium system developments. The vanadium alloy development activity included four subtasks: (1.1) baseline mechanical properties of non irradiated base metal and weld metal joints; (1.2) compatibility with liquid lithium; (1.3) material irradiation tests; and (1.4) development of material manufacturing and joining methods. The lithium blanket technology activity included four subtasks: (2.1) electrical insulation development and testing for liquid metal systems; (2.2) MHD pressure drop and heat transfer study for self-cooled liquid metal systems; (2.3) chemistry of liquid lithium; and (2.4) design, fabrication and testing of ITER relevant size blanket mockups. A summary of the progress and results obtained during the period 1995 and 1996 in each of the subtask areas is presented in this report.

  1. Shelf-Life of ɛ-Lysyl-3-(Trimethylstannyl)Benzamide Immunoconjugates, Precursors for 211At Labeling of Antibodies

    OpenAIRE

    Aneheim, Emma; Halleröd, Jenny; Albertsson, Per; Jensen, Holger; Holgersson, Stellan; Lindegren, Sture

    2015-01-01

    Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it comes to the treatment of occult disseminated cancer. Preclinical research has proven effective, and patient studies have been initiated based on these results. However, a lack of production capacity and the complex radiochemistry of 211At are major obstacles for research and prospective clinical applications. In the present study, astatination of immunoconjugates, already prepared well in advance...

  2. Technical-evaluation report on the monitoring of electric power to the reactor-protection system for the Oyster Creek Nuclear Generating Station. (Docket No. 50-219)

    International Nuclear Information System (INIS)

    During the operating license review for Hatch 2, the Nuclear Regulatory Commission (NRC) staff raised a concern about the capability of the Class 1E reactor protection system (RPS) to operate after suffering sustained, abnormal voltage or frequency conditions from a non-Class 1E power supply. Abnormal voltage or frequency conditions could be produced as a result of one of the following causes: combinations of undetected, random single failures of the power supply components, or multiple failures of the power supply components caused by external phenomena such as a seismic event. The purpose of this report is to evaluate the licensees submittal with respect to the NRC criteria and present the reviewer's conclusion on the adequacy of the design modifications to protect the RPS from abnormal voltage and frequency conditions

  3. Proceedings of US/Japan workshop, Q219 on high heat flux components and plasma surface interactions for next fusion devices

    Energy Technology Data Exchange (ETDEWEB)

    Ulrickson, M.A.; Stevens, P.L.; Hino, T.; Hirohata, Y. [eds.

    1996-12-01

    This report contains the viewgraphs from the proceedings of US/Japan Workshop on High Heat Flux Components and Plasma Surface Interactions for Next Fusion Devices. Some of the general topics covered by this report are: PFC/PSI in tokamak and helical devices; development of high heat flux components; PSIS and plasma facing materials;tritium; and material damage.

  4. Improving Lowland Rice (O. sativa L. cv. MR219 Plant Growth Variables, Nutrients Uptake, and Nutrients Recovery Using Crude Humic Substances

    Directory of Open Access Journals (Sweden)

    Perumal Palanivell

    2015-01-01

    Full Text Available High cation exchange capacity and organic matter content of crude humic substances from compost could be exploited to reduce ammonia loss from urea and to as well improve rice growth and soil chemical properties for efficient nutrients utilization in lowland rice cultivation. Close-dynamic air flow system was used to determine the effects of crude humic substances on ammonia volatilization. A pot experiment was conducted to determine the effects of crude humic substances on rice plant growth, nutrients uptake, nutrients recovery, and soil chemical properties using an acid soil mixed with three rates of crude humic substances (20, 40, and 60 g pot−1. Standard procedures were used to evaluate rice plant dry matter production, nutrients uptake, nutrients recovery, and soil chemical properties. Application of crude humic substances increased ammonia volatilization. However, the lowest rate of crude humic substances (20 g pot−1 significantly improved total dry matter, nutrients uptake, nutrients recovery, and soil nutrients availability compared with crude humic substances (40 and 60 g pot−1 and the normal fertilization. Apart from improving growth of rice plants, crude humic substances can be used to ameliorate acid soils in rice cultivation. The findings of this study are being validated in our ongoing field trials.

  5. Reliability and measurement error of frontal and horizontal 3D spinal motion parameters in 219 patients with chronic low back pain

    DEFF Research Database (Denmark)

    Harsted, Steen; Mieritz, Rune M; Bronfort, Gert;

    2016-01-01

    were evaluated using intraclass correlation coefficients ICC(1,1) and Bland-Altman limits of agreement (LOAs). RESULTS: The reliability analysis based on the whole study sample showed ICC(1,1) coefficients varying between 0.68 and 0.73 for the frontal plane and 0.33 and 0.49 for the horizontal plane....... Relatively wide LOAs were observed for all parameters. Reliability measures in patient subgroups ICC(1,1) ranged between 0.55 and 0.81 for the frontal plane and 0.28 and 0.69 for the horizontal plane. Greater ICC(1,1) coefficients and smaller LOA were observed when patients were examined by the same examiner...

  6. 77 FR 62315 - Holiday CVS, L.L.C., d/b/a CVS/Pharmacy Nos. 219 and 5195; Decision and Order

    Science.gov (United States)

    2012-10-12

    ... that * * * as a pharmacist, she is not trained to diagnose, and it's up to the doctor to determine... pursuant to prescriptions, which raised red flags that a pharmacist could not resolve, and thus violated....; Revocation of Registration, 75 FR 78,745, 78,752-54 (2010). Pursuant to Agency practice, the decision...

  7. Integrated plant safety assessment: systematic evaluation program. Oyster Creek nuclear generating station. GPU Nuclear Corporation and Jersey Central Power and Light Company. Docket No. 50-219

    International Nuclear Information System (INIS)

    The Systematic Evaluation Program was initiated in February 1978 by the US Nuclear Regulatory Commission to review the designs of older operating nuclear reactor plants to reconfirm and document their safety. The review provides (1) an assessment of how these plants compare with current licensing safety requirements relating to selected issues, (2) a basis for deciding on how these differences should be resolved in an integrated plant review, and (3) a documented evaluation of plant safety. This report documents the review of the Oyster Creek Nuclear Generating Station (located in Ocean County, New Jersey), one of ten plants reviewed under Phase II of this program, and indicates how 137 topics selected for review under Phase I of the program were addressed. Equipment and procedural changes have been identified as a result of the review. It is expected that this report will be one of the bases in considering the issuance of a full-term operating license in place of the existing provisional operating license

  8. SU-E-J-219: A Dixon Based Pseudo-CT Generation Method for MR-Only Radiotherapy Treatment Planning of the Pelvis and Head and Neck

    Energy Technology Data Exchange (ETDEWEB)

    Maspero, M.; Meijer, G.J.; Lagendijk, J.J.W.; Berg, C.A.T. van den [Department of Radiotherapy, UMC Utrecht (Netherlands); Seevinck, P.R.; Viergever, M.A. [Image Science Institute, UMC Utrecht (Netherlands)

    2015-06-15

    Purpose: To develop an image processing method for MRI-based generation of electron density maps, known as pseudo-CT (pCT), without usage of model- or atlas-based segmentation, and to evaluate the method in the pelvic and head-neck region against CT. Methods: CT and MRI scans were obtained from the pelvic region of four patients in supine position using a flat table top only for CT. Stratified CT maps were generated by classifying each voxel based on HU ranges into one of four classes: air, adipose tissue, soft tissue or bone.A hierarchical region-selective algorithm, based on automatic thresholding and clustering, was used to classify tissues from MR Dixon reconstructed fat, In-Phase (IP) and Opposed-Phase (OP) images. First, a body mask was obtained by thresholding the IP image. Subsequently, an automatic threshold on the Dixon fat image differentiated soft and adipose tissue. K-means clustering on IP and OP images resulted in a mask that, via a connected neighborhood analysis, allowing the user to select the components corresponding to bone structures.The pCT was estimated through assignment of bulk HU to the tissue classes. Bone-only Digital Reconstructed Radiographs (DRR) were generated as well. The pCT images were rigidly registered to the stratified CT to allow a volumetric and voxelwise comparison. Moreover, pCTs were also calculated within the head-neck region in two volunteers using the same pipeline. Results: The volumetric comparison resulted in differences <1% for each tissue class. A voxelwise comparison showed a good classification, ranging from 64% to 98%. The primary misclassified classes were adipose/soft tissue and bone/soft tissue. As the patients have been imaged on different table tops, part of the misclassification error can be explained by misregistration. Conclusion: The proposed approach does not rely on an anatomy model providing the flexibility to successfully generate the pCT in two different body sites. This research is founded by ZonMw IMDI Programme, project name: “RASOR sharp: MRI based radiotherapy planning using a single MRI sequence”, project number: 10-104003010.

  9. Safety Evaluation Report related to the full-term operating license for Oyster Creek Nuclear Generating Station (Docket No. 50-219)

    International Nuclear Information System (INIS)

    The Safety Evaluation Report for the full-term operating license application filed by GPU Nuclear Corporation and Jersey Central Power ampersand Light Company for the Oyster Creek Nuclear Generating Station has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located in Ocean County, New Jersey. The staff concludes that the facility can continue to be operated without endangering the health and safety of the public. 1 figs., 5 tabs

  10. Proceedings of US/Japan workshop, Q219 on high heat flux components and plasma surface interactions for next fusion devices

    International Nuclear Information System (INIS)

    This report contains the viewgraphs from the proceedings of US/Japan Workshop on High Heat Flux Components and Plasma Surface Interactions for Next Fusion Devices. Some of the general topics covered by this report are: PFC/PSI in tokamak and helical devices; development of high heat flux components; PSIS and plasma facing materials;tritium; and material damage

  11. Investigations of the in Planta Expression of Active Cellobiohydrolase I: Cooperative Research and Development Final Report, CRADA Number CRD-07-219

    Energy Technology Data Exchange (ETDEWEB)

    Himmel, M.

    2011-02-01

    It was the purpose of this project to determine if cellulases produced in transgenic plants could effectively be utilized in the production of ethanol and other feedstock chemicals from lignocellulosic substrates.

  12. SU-E-J-219: Quantitative Evaluation of Motion Effects On Accuracy of Image-Guided Radiotherapy with Fiducial Markers Using CT Imaging

    International Nuclear Information System (INIS)

    Purpose: To investigate quantitatively patient motion effects on the localization accuracy of image-guided radiation with fiducial markers using axial CT (ACT), helical CT (HCT) and cone-beam CT (CBCT) using modeling and experimental phantom studies. Methods: Markers with different lengths (2.5 mm, 5 mm, 10 mm, and 20 mm) were inserted in a mobile thorax phantom which was imaged using ACT, HCT and CBCT. The phantom moved with sinusoidal motion with amplitudes ranging 0–20 mm and a frequency of 15 cycles-per-minute. Three parameters that include: apparent marker lengths, center position and distance between the centers of the markers were measured in the different CT images of the mobile phantom. A motion mathematical model was derived to predict the variations in the previous three parameters and their dependence on the motion in the different imaging modalities. Results: In CBCT, the measured marker lengths increased linearly with increase in motion amplitude. For example, the apparent length of the 10 mm marker was about 20 mm when phantom moved with amplitude of 5 mm. Although the markers have elongated, the center position and the distance between markers remained at the same position for different motion amplitudes in CBCT. These parameters were not affected by motion frequency and phase in CBCT. In HCT and ACT, the measured marker length, center and distance between markers varied irregularly with motion parameters. The apparent lengths of the markers varied with inverse of the phantom velocity which depends on motion frequency and phase. Similarly the center position and distance between markers varied inversely with phantom speed. Conclusion: Motion may lead to variations in maker length, center position and distance between markers using CT imaging. These effects should be considered in patient setup using image-guided radiation therapy based on fiducial markers matching using 2D-radiographs or volumetric CT imaging

  13. SU-E-J-219: A Dixon Based Pseudo-CT Generation Method for MR-Only Radiotherapy Treatment Planning of the Pelvis and Head and Neck

    International Nuclear Information System (INIS)

    Purpose: To develop an image processing method for MRI-based generation of electron density maps, known as pseudo-CT (pCT), without usage of model- or atlas-based segmentation, and to evaluate the method in the pelvic and head-neck region against CT. Methods: CT and MRI scans were obtained from the pelvic region of four patients in supine position using a flat table top only for CT. Stratified CT maps were generated by classifying each voxel based on HU ranges into one of four classes: air, adipose tissue, soft tissue or bone.A hierarchical region-selective algorithm, based on automatic thresholding and clustering, was used to classify tissues from MR Dixon reconstructed fat, In-Phase (IP) and Opposed-Phase (OP) images. First, a body mask was obtained by thresholding the IP image. Subsequently, an automatic threshold on the Dixon fat image differentiated soft and adipose tissue. K-means clustering on IP and OP images resulted in a mask that, via a connected neighborhood analysis, allowing the user to select the components corresponding to bone structures.The pCT was estimated through assignment of bulk HU to the tissue classes. Bone-only Digital Reconstructed Radiographs (DRR) were generated as well. The pCT images were rigidly registered to the stratified CT to allow a volumetric and voxelwise comparison. Moreover, pCTs were also calculated within the head-neck region in two volunteers using the same pipeline. Results: The volumetric comparison resulted in differences <1% for each tissue class. A voxelwise comparison showed a good classification, ranging from 64% to 98%. The primary misclassified classes were adipose/soft tissue and bone/soft tissue. As the patients have been imaged on different table tops, part of the misclassification error can be explained by misregistration. Conclusion: The proposed approach does not rely on an anatomy model providing the flexibility to successfully generate the pCT in two different body sites. This research is founded by ZonMw IMDI Programme, project name: “RASOR sharp: MRI based radiotherapy planning using a single MRI sequence”, project number: 10-104003010

  14. SU-E-J-219: Quantitative Evaluation of Motion Effects On Accuracy of Image-Guided Radiotherapy with Fiducial Markers Using CT Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Ali, I; Oyewale, S; Ahmad, S; Algan, O [University of Oklahoma Health Sciences, Oklahoma City, OK (United States); Alsbou, N [Department of Electrical and Computer Engineering, Ada, OH (United States)

    2014-06-01

    Purpose: To investigate quantitatively patient motion effects on the localization accuracy of image-guided radiation with fiducial markers using axial CT (ACT), helical CT (HCT) and cone-beam CT (CBCT) using modeling and experimental phantom studies. Methods: Markers with different lengths (2.5 mm, 5 mm, 10 mm, and 20 mm) were inserted in a mobile thorax phantom which was imaged using ACT, HCT and CBCT. The phantom moved with sinusoidal motion with amplitudes ranging 0–20 mm and a frequency of 15 cycles-per-minute. Three parameters that include: apparent marker lengths, center position and distance between the centers of the markers were measured in the different CT images of the mobile phantom. A motion mathematical model was derived to predict the variations in the previous three parameters and their dependence on the motion in the different imaging modalities. Results: In CBCT, the measured marker lengths increased linearly with increase in motion amplitude. For example, the apparent length of the 10 mm marker was about 20 mm when phantom moved with amplitude of 5 mm. Although the markers have elongated, the center position and the distance between markers remained at the same position for different motion amplitudes in CBCT. These parameters were not affected by motion frequency and phase in CBCT. In HCT and ACT, the measured marker length, center and distance between markers varied irregularly with motion parameters. The apparent lengths of the markers varied with inverse of the phantom velocity which depends on motion frequency and phase. Similarly the center position and distance between markers varied inversely with phantom speed. Conclusion: Motion may lead to variations in maker length, center position and distance between markers using CT imaging. These effects should be considered in patient setup using image-guided radiation therapy based on fiducial markers matching using 2D-radiographs or volumetric CT imaging.

  15. 中药贯序疗法治疗肝癌围肝动脉栓塞化疗期患者219例临床观察%Clinical Investigation on Chinese Herb Sequential Therapy for 219 Cases of Liver Cancer with Embolism of Peripheral Hepatic Artery at Chemotherapeutic Stage

    Institute of Scientific and Technical Information of China (English)

    苏小康; 周伟生; 徐发彬; 王芳军; 赵天清; 林宜胜; 温凤媚; 崔学教

    2004-01-01

    目的:探讨中药贯序治疗在肝癌围肝动脉栓塞术(TACE)中的作用.方法:收集438例中晚期肝癌行TACE患者,分为肝郁脾虚型(14%)、气滞血瘀型(42%)、湿热蕴结型(29%)、肝肾阴虚型(15%)4型,随症加减中药治疗.配对观察TACE术中碘油用量,术后肝储备功能、影像学资料、毒副反应和免疫功能的差别.结果:在中药贯序支持治疗下TACE术后患者肝功能CHILD-Pugh和ICGR15损害明显减轻(P<0.05),免疫抑制减轻,对抗发热、胃肠道反应、黄疸、腹水等毒副反应(P<0.01),也可以抑制脾脏肿大,但是对术中碘油用量、肿瘤大小和包膜形成影响不大(P>0.05).结论:围TACE中药贯序支持治疗可以减轻肝功能损害,对抗术后毒副反应,减轻免疫抑制,但对影像学资料和术中碘油用量影响不大.

  16. Shelf-life of ɛ-lysyl-3-(trimethylstannyl)benzamide immunoconjugates, precursors for 211At labeling of antibodies

    DEFF Research Database (Denmark)

    Aneheim, Emma; Halleröd, Jenny; Albertsson, Per;

    2015-01-01

    Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it comes to the treatment of occult disseminated cancer. Preclinical research has proven effective, and patient studies have been initiated based on these results. However, a lack of production capacity ...

  17. SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995

    Energy Technology Data Exchange (ETDEWEB)

    Jaszczak, R.J.

    1995-12-01

    Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed tomography (SPECT) quantification of iodine 123 and astatine 211; and the development and evaluation of SPECT pinhole imaging for low and medium energy photons.

  18. SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995

    International Nuclear Information System (INIS)

    Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed tomography (SPECT) quantification of iodine 123 and astatine 211; and the development and evaluation of SPECT pinhole imaging for low and medium energy photons

  19. Separation of 211At from irradiated bismuth target and labelling of a model protein

    International Nuclear Information System (INIS)

    Astatine-211 is a promising radionuclide for therapeutic use in nuclear medicine. An efficient method (70%) for radiochemical separation from the irradiated Bi-target has been described. The level of Bi contamination in the purified 2'11At-solution was estimated. Finally labelling of a model protein has been tried. (author). 14 refs

  20. 75 FR 3221 - Ruby Pipeline, L.L.C.; Notice of Availability of the Final Environmental Impact Statement for the...

    Science.gov (United States)

    2010-01-20

    ... 219, Section 219.35(b) (published in the Federal Register at 65 FR 67514 ; see also 36 CFR 219 Interpretive Rule published at 66 FR 1864 ) and found at http://www.fs.fed.us/appeals/appeals_related.php#app_work . The objection procedures found at 36 CFR 219.32 (published in the Federal Register at 65...

  1. Petrographic atlas characterisation of aggregates regarding potential reactivity to alkalis : RILEM TC 219-ACS recommended guidance AAR-1.2, for use with the RILEM AAR-1.1 petrographic examination method

    CERN Document Server

    Ribeiro, Maria; Broekmans, Maarten; Sims, Ian

    2016-01-01

    This RILEM AAR 1.2 Atlas is complementary to the petrographic method described in RILEM AAR 1.1. It is designed and intended to assist in the identification of alkali-reactive rock types in concrete aggregate by thin-section petrography. Additional issues include: • optical thin-section petrography conforming to RILEM AAR 1.1 is considered the prime assessment method for aggregate materials, being effective regarding cost and time. Unequivocal identification of minerals in very-fine grained rock types may however require use of supplementary methods. • the atlas adheres to internationally adopted schemes for rock classification and nomenclature, as recommended in AAR 1.1. Thus, rock types are classified as igneous, sedimentary or metamorphic based upon mineral content, microstructure and texture/fabric. • in addition, the atlas identifies known alkali-reactive silica types in each rock type presented. It also identifies consistent coincidence between certain lithologies and silica types; however, it ref...

  2. RILEM recommendations for the prevention of damage by alkali-aggregate reactions in new concrete structures state-of-the-art report of the RILEM technical committee 219-ACS

    CERN Document Server

    Sims, Ian

    2016-01-01

    This book contains the full set of RILEM Recommendations which have been produced to enable engineers, specifiers and testing houses to design and produce concrete which will not suffer damage arising from alkali reactions in the concrete. There are five recommended test methods for aggregates (designated AAR-1 to AAR-5), and an overall recommendation which describes how these should be used to enable a comprehensive aggregate assessment (AAR-0). Additionally, there are two Recommended International Specifications for concrete (AAR-7.1 & 7.2) and a Preliminary International Specification for dams and other hydro structures (AAR-7.3), which describe how the aggregate assessment can be combined with other measures in the design of the concrete to produce a concrete with a minimised risk of developing damage from alkali-aggregate reactions.

  3. PENGARUH PENGGUNAAN GLIKOL PADA INSEKTISIDA AQUA-K-OTHRINE 20 EW® (b.a. Deltamethrin 21.9 g/l TERHADAP NYAMUK Aedes aegypti dan Culex quinquefasciatus DENGAN METODA PENGASAPAN(Thermal Fogging

    Directory of Open Access Journals (Sweden)

    Hasan Boesri

    2011-12-01

    Full Text Available ENGLISHK-OTHRINE 20 EW® insecticides were tested in 100 and 200 ml/ha with the application of fumigation using pure water as solvent and mixture of water and glycol. It was equally effective to kill Ae. aegypti mosquitoes indoor and outdoor with the mortality of 100%. Similarly, the insecticide effectively provides mortality of 90.0 – 94.8% to the Cx. quinquefasciatus mosquitoes, indoor and outdoor. The effect of fumigation of K-Othrine 20 EW® insecticide using either pure or mixed solvent of water (9.5 l water + 0.5 l glycol showed no difference to the mortality of mosquitoes, but glycol solution produce the fog, so the particle could be spread out to all directions.INDONESIAPengujian insektisida K-OTHRINE 20 EW® dosis 100 dan 200 ml/ha telah dilakukan dengan aplikasi pengasapan menggunakan pelarut air dan campuran air dengan glikol. Hasil menunjukkan keduanya sama-sama efektif membunuh nyamuk Aedes aegypti di dalam dan luar rumah (kematian 100%; terhadap Culex quinquefasciatus di dalam dan luar rumah efektif memberikan kematian 90.0 – 90.8%. Pengaruh aplikasi pengasapan insektisida K-Othrine 20 EW® baik menggunakan pelarut air maupun campuran (9.5 l air + 0.5 l glikol menunjukkan tidak berbeda terhadap kematian nyamuk uji, perbedaan pada larutan yang ditambah glikol dapat mengeluarkan kabut sehingga partikel yang dikeluarkan dapat tersebar ke semua arah.

  4. Thermosalinograph data of the Hawaii Ocean Time-series (HOT) program in the North Pacific 100 Miles North of Oahu, Hawaii for Cruises HOT219-227 during 2010 (NODC Accession 0087988)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The HOT program makes repeated observations of the physics, biology and chemistry at a site approximately 100 km north of Oahu, Hawaii. Two stations are visited...

  5. Depaule Jean-Charles (avec la collaboration de Jean-Luc Arnaud, À travers le mur, Marseille, éditions Parenthèses, collection Eupalinos, 2014, 219 p.

    Directory of Open Access Journals (Sweden)

    Anna Madoeuf

    2014-09-01

    Full Text Available Saluons la réédition, aux éditions Parenthèses, dans la collection Eupalinos, d’À travers le mur, de Jean-Charles Depaule, ouvrage qui est tant une contribution rare et originale aux études urbaines, qu’un opus d’anthropologie sur l’espace habité, de même qu’une source de références multiples, notamment littéraires. « Rêver des lourdes portes, des passages en chicane et plus encore, peut-être des moucharabiehs perdus […] ». Cette sollicitation onirique et énigmatique, quatrième de couverture ...

  6. Application of solar energy to the supply of industrial process hot water: preliminary design and performance report. Volume I. Technical report. Aerotherm report TR-76-219. [For can washing at Campbell Soup Plant in Sacramento

    Energy Technology Data Exchange (ETDEWEB)

    None

    1976-10-14

    The design and performance of a solar hot water system for can washing at the Campbell Soup Plant in Sacramento, California, are presented. The collector field is located on the roof of the finished products warehouse of the Campbell Soup Sacramento plant. Water is supplied from a 3.8 cm (1/sup 1///sub 2/ in.) supply line which is located directly below an existing roof access hatch. A supply pipe will be brought up through that hatch. The water flow will then be split into two manifold lines which supply the dual rows of flat plate collectors. The preheated water from the flat plates is then passed into six sets of parallel connected concentrators. Each set consist of eight 1.83 x 3.05 m (6 x 10 foot) modules connected in series. The water from these units is gathered in a 3.8 cm (1/sup 1///sub 2/ in.) insulated pipe which transports it to the storage tank. This pipe will be attached to an existing pipe run until it reaches the can washing building. From there the pipe will follow the can washing building around to the storage tank. The storage tank is a 75,200 1 (20,000 gal) steel tank which is coated internally with a USDA approved phenolic liner. The outside of the tank is insulated. A 2.2 kw (3 hp) motor is used to pump the stored water for the tank into the can washing line. Detail drawings and descriptions of the collector field, installation, piping, controls, data acquisition equipment, and roof structure are included. Furthermore, a program schedule with equipment and manpower costs for successfully completing Phase II of this contract is included. Also included is an organization chart of the Phase II program personnel. (WHK)

  7. Hurdles for a Broader Use of 211At and for the Synthesis of 211At-Labelled Radiopharmaceuticals at High Activities for Clinical Use

    International Nuclear Information System (INIS)

    One of the key impediments to the use of 211At is the very well known deleterious effect of high radiation fields caused by its alpha particles on the synthesis of 211At-labelled radiopharmaceuticals. This is problematic because radiolysis-mediated effects can produce diminishing efficiency of electrophilic astatination reactions due to increasing deposition of radiation dose with increasing activities and with the passage of the time. Astatine-211 has chemical properties that permit complex labelling strategies and a longer half-life than 213Bi that makes it more suitable when the targeting molecule does not gain immediate access to the tumour cells. The first clinical evaluation was published in 2001 [2] in patients with brain tumour. Although this study circumvents many of the challenges to entering clinical studies with 211At and many obstacles had to be surmounted before clinical studies could be initiated, several problems were encountered in maintaining efficient labelling with escalating radiation dose of α-particle even with fresh 211At elution [3]. Astatine-211 also has an additional hurdle to overcome before to its clinical application in labelled radiopharmaceuticals related with its production and distribution. Among the potential group of promising α- emitter it is the only one produced by cyclotrons, but due to the scarcity of cyclotrons equipped with 25−30 MeV α-particle beams, it will of necessity be utilized in distant locations from the site of production. It presents a major chemical challenge because the diminishing efficiency of electrophilic astatination reactions with the passage of the time is well known, a problem likely related to the radiolysis produced by the high LET (linear energy transfer) meaning that large amounts of energy are deposited in a highly localized manner. This problem has been most comprehensively investigated to understand and evaluate the role of the radiolysis effects of astatine alpha particles in the synthesis

  8. $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with radioactive At beams

    CERN Multimedia

    We propose to study the $\\beta$-delayed fission, laser spectroscopy and radioactive decay of the newly available pure beams of neutron-deficient and neutron-rich astatine (Z=85) isotopes. The fission probability and the fission fragment distribution of the even-even isotopes $^{194,196}$Po following the $\\beta$-decay of the isotopes $^{194,196}$At will be studied with the Windmill setup. In-source laser spectroscopy will be performed on the entire astatine isotopic chain, using a combination of the Windmill setup, ISOLTRAP MR-ToF and ISOLDE Faraday. Radioactive decay data will be acquired at the Windmill setup throughout those studies and contribute to the global understanding of the phenomenon of shape coexistence in the neutron-deficient lead region.

  9. Production cross section of At radionuclides from $^{7}$Li+$^{\\textrm{nat}}$Pb and $^{9}$Be+$^{\\textrm{nat}}$Tl reactions

    CERN Document Server

    Maiti, Moumita

    2011-01-01

    Earlier we reported theoretical studies on the probable production of astatine radionuclides from $^{6,7}$Li and $^{9}$Be-induced reactions on natural lead and thalliun targets, respectively. For the first time, in this report, production of astatine radionuclides has been investigated experimentally with two heavy ion induced reactions: $^{9}$Be+$^{\\textrm{nat}}$Tl and $^{7}$Li+$^{\\textrm{nat}}$Pb. Formation cross sections of the evaporation residues, $^{207,208,209,210}$At, produced in (HI, xn) channel, have been measured by the stacked-foil technique followed by the off-line $\\gamma$-spectrometry at the low incident energies ($<$50 MeV). Measured excitation functions have been explained in terms of compound nuclear reaction mechanism using Weisskopf-Ewing and Hauser-Feshbach model. Absolute cross section values are lower than the respective theoretical predictions.

  10. Radiopharmaceutical Chemistry of Targeted Radiopharmaceutics. Synthesis of 211At-Labeled Radiopharmaceuticals at High Activities for Clinical Use

    International Nuclear Information System (INIS)

    Targeted α-particle radiotherapy is an appealing approach to cancer treatment because of the potential for delivering curative doses of radiation to tumor with minimal damage to normal tissue due to a range equivalent to only a few cell diameters. Compared with β-emitters they have significant advantages from a radiobiological perspective. The LET of 211At α-particles is more than 400 times higher than the β-particles emitted by 90Y, in addition the distance between ionizing events is almost the same as that between the two strands of DNA, yielding a high probability of creating non-repairable DNA damage. It gives the ability to kill cancer cells not compromised by hypoxia, dose rate effects or cell cycle position, enhancing their attractiveness for targeted radiotherapy. However, translation of the concept to the clinic has been slow, many obstacles had to be surmounted before clinical studies could be initiated, the first clinical evaluation of a 211At- labeled mAb was made in 2001. This study circumvents many of the challenges to entering clinical studies with 211At. But several problems were encountered in maintaining efficient labeling with escalating radiation dose of alpha-particle likely related to radiolysis. The impact of the radiolysis produced by the α-particle over the labeling chemistry is much higher in comparison with typical β-emitters due to a deposition of energy in the solvent in a highly localized manner two orders of magnitude per unit volume higher than 90Y or 131I. Due to these difficulties a comprehensive basic science study about the radiolytic effects of astatine alpha-particles over the synthesis of 211At-labeled radiopharmaceuticals was carried out. Its main goal was overcoming the problem of the synthesis of 211At-labeled radiopharmaceuticals at the high activities necessaries for therapy and also to extend the shelf life of astatine elutions. Briefly this study held several steps, the first one was to study the role of solvent

  11. Grids of Agricultural Pesticide Use in the Conterminous United States, 1997

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This spatial dataset consists of 219 1-kilometer (km) resolution grids depicting estimated agricultural use of 219 pesticides in 1997 for the conterminous United...

  12. Radiohalogenation of biomolecules. An experimental study on radiohalogen preparation, precursor synthesis, radiolabeling and biodistribution

    International Nuclear Information System (INIS)

    Radiohalogens are widely used in nuclear medicine, both as tool for diagnostic in vivo imaging, and in radionuclide therapy. This study deals with the use of radiohalogens; separation, precursor synthesis, labeling and biological behavior. The focus is on 211At and 124I, the former being a candidate for nuclide therapy and the latter potentially useful for diagnostic imaging and Auger-electron based radiotherapy. For astatine the separation, labeling and some biological behavior is described, and for iodine the latter two. Astatine was separated from an irradiated bismuth target by dry distillation. A novel cryotrap was developed for the isolation of astatine and subsequent synthesis of radiolabeled compounds. 5-[211At]astato-2'-deoxyuridine (AUdR) and N-succinimidyl-4-[211At]astatobenzoate (SAB) were synthesized in 95% respectively 90% radiochemical yields. The former is incorporated into DNA of proliferating cells and can therefore be used as an endoradiotherapeutic agent. The latter is a conjugate for the astatination of proteins. Human epidermal growth factor (hEGF) was tagged with astatine using three approaches: a) direct labeling of native hEGF, b) conjugation with SAB, and c) direct labeling of an hEGF - 7-(3-aminopropyl)-7,8-dicarba-nido-undecaborate(1-) conjugate. The overall labeling yields were 3.5% for direct labeling, 44% for SAB and 70% for the hEGF-nido-carborane conjugate. A new route to N-succinimidyl 3- and 4- [124I]iodobenzoate, two reagents for radioiodination of proteins is described affording 90% radiochemical yield. Three radioiodinated analogs of PK11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxyam ide, a peripheral-type benzodiazepine receptor antagonist, were synthesized. All three analogs were obtained in >90% radiochemical yield. Synthesis and application of 5-[124I]iodo-2'-deoxyuridine (IUdR) is presented. The closo-dodecaborate anion was evaluated as prosthetic group for radioiodination of macromolecules

  13. 211At production and recovery: first results of a new start

    International Nuclear Information System (INIS)

    Full text: 211At is the only alpha-emitting isotope which can be introduced into organic molecular structures by covalent chemical binding and possesses superior decay characteristics for therapeutic applications when compared with other alpha emitters. However, its production requires a minimum of 27,5 MeV alpha-particles, which are relatively rarely available. In view of the revival of alpha-therapy approaches a production of 211At has been set up at the MHH cyclotron (MC-35). The first aim of this project was to establish a target- and work-up-system for the reliable production of several ten MBq-quantities of 211At for animal- and cell-research. An aluminum-target-system holds a 1.3 cm diameter Bi-disc of 0.25 mm thickness. The disk is pressed onto a the aluminum backing with 2 tons/cm2. The front is covered with a 125 μm Al foil, cooled by a He jet which is separated from the vacuum by a 250 μm Ti foil. Starting with 27.5 MeV alpha-particles the resulting target-energy is 25 MeV. This relatively low energy is chosen to avoid any contamination with 210At and 210Po in the first experimental period. A beam current of 10 μA for 15 min (9 mCoulomb) yields 16.4 MBq 211At theoretically. Astatine is recovered from the target by a dry distillation technique, using various gases as a transport support-medium. The small all-quartz distillation-apparatus is heated up to 900 oC. Astatine is recovered in a small cool able vessel containing various trapping media. Distillation and trapping can be monitored with small radioactivity monitors. The whole system fits in a cubical 0.5 m glove box. Continuous monitoring of the distillation process allowed to optimize the heating rate, the transport support-medium and its flow-rate. Various trapping solutions were tested for their efficiency. Different beam dispersion in the target seems to influence the release and distillation of astatine from the molten bismuth-target. Two different release patterns were observed. The first

  14. Inclusive measurement of (p,πsup(-)xn) double charge exchange reactions on bismuth from threshold to 800 MeV

    International Nuclear Information System (INIS)

    The energy dependence of the total angle-integrated cross section for the production of astatine isotopes from (p,πsup(-)xn) double charge exchange reactions on bismuth (sup(209)Bi) was measured from 120 to 800 MeV using activation and radiochemical techniques. Chemical yields were estimated by direct radioassaying of sup(211)At activity in thin (approximately 1 mg/cmsup(2)), irradiated bismuth targets. Calculations of the contributions of secondary (2-step) reactions to these measured astatine yields were performed, based partially upon the observed sup(211)At activity although even at the highest energies, the contribution to products lighter than sup(207)At was negligible. These data for products with as many as 7 neutrons removed from the doubly coherent product (sup(210)At) display nearby gaussian shapes for the mass distributions of the astatine residues with the maximum occurring for about sup(204)At. The most probable momentum transfer deduced from these distributions for the initial πsup(-) production step was 335 MeV/c. The observed excitation functions display a behaviour similar to that observed for the yield of sup(210)Po from a (p,πsup(O)) reaction on sup(209)Bi, but radically different from that observed for inclusive πsup(-) reactions on a heavy nucleus. These data are discussed in terms of recent theoretical approaches to negative pion production from bismuth. In addition, a simple, schematic model is developed to treat the rapidly decreasing percentage of the total inclusive πsup(-) emission which is observed for this double charge exchange reaction. This model reflects the capacity of a nucleus to a source of internal energetic protons

  15. EFFECT OF MECHANICAL PROPERTIES OF MARTENSITE AND LOADING RATE ON DUAL PHASE STEELS

    OpenAIRE

    BAYRAM, Ali

    1998-01-01

    In this study, steel sheet materials were used in order to obtain dual-phase steel. Specimens for this purpose have been annealed in ferrite + astatine regions at the temperatures of 740, 760, 800 and 820 °C. The specimens were annealed at the different temperatures with corresponding times 20, 40 and 60 minutes and quenched into water. As a result of this dual-phase steels at different ferrite + martensite ratio were produced. Sheet specimens were tested at the range of loading rates of 1...

  16. Human radiation studies: Remembering the early years: Oral history of Dr. Patricia Wallace Durbin, Ph.D., conducted November 11, 1994

    International Nuclear Information System (INIS)

    This report is a transcript of an interview of Dr. Patricia Wallace Durbin by representatives of the US DOE Office of Human Radiation Research. Dr. Durbin was selected for this interview because of her knowledge of the human plutonium injections and her recollections of key figures, especially Joseph Hamilton. After a brief biographical sketch Dr. Durbin discusses her loss of research funding from DOE, her recollections concerning research into strontium metabolism as part of Project Sunshine, her recollections relating to the rationale for studies of human metabolism of radionuclides, her remembrances of Dr. Hamilton's Astatine and Plutonium research, and her experiences in gathering archival records concerning these researches

  17. AcEST: BP914632 [AcEST

    Lifescience Database Archive (English)

    Full Text Available ion tr|A2Q219|A2Q219_MEDTR Xanthine/uracil/vitamin C permease (Fragment) OS=Medicago truncatula...g significant alignments: (bits) Value tr|A2Q219|A2Q219_MEDTR Xanthine/uracil/vitamin... OS=Zea m... 35 2.8 >tr|A2Q219|A2Q219_MEDTR Xanthine/uracil/vitamin... 5.1 sp|P42345|FRAP_HUMAN FKBP12-rapamycin complex-associated protein... 30 5.1 s...lla paten... 44 0.006 tr|Q5N911|Q5N911_ORYSJ cDNA clone:J013164P20, full insert sequen... 40 0.087 tr|B8ACH2|B8ACH2_ORYSI Puta

  18. Dietary exposure to benzoates (E210-E213), parabens (E214-E219), nitrites (E249-E250), nitrates (E251-E252), BHA (E320), BHT (E321) and aspartame (E951) in children less than 3 years old in France.

    Science.gov (United States)

    Mancini, F R; Paul, D; Gauvreau, J; Volatier, J L; Vin, K; Hulin, M

    2015-01-01

    This study aimed to estimate the exposure to seven additives (benzoates, parabens, nitrites, nitrates, BHA, BHT and aspartame) in children aged less than 3 years old in France. A conservative approach, combining individual consumption data with maximum permitted levels, was carried out for all the additives. More refined estimates using occurrence data obtained from products' labels (collected by the French Observatory of Food Quality) were conducted for those additives that exceeded the acceptable daily intake (ADI). Information on additives' occurrence was obtained from the food labels. When the ADI was still exceeded, the exposure estimate was further refined using measured concentration data, if available. When using the maximum permitted level (MPL), the ADI was exceeded for benzoates (1.94 mg kg(-1) bw day(-1)), nitrites (0.09 mg kg(-1) bw day(-1)) and BHA (0.39 mg kg(-1) bw day(-1)) in 25%, 54% and 20% of the entire study population respectively. The main food contributors identified with this approach were current foods as these additives are not authorised in specific infant food: vegetable soups and broths for both benzoates and BHA, delicatessen and meat for nitrites. The exposure estimate was significantly reduced when using occurrence data, but in the upper-bound scenario the ADI was still exceeded significantly by the age group 13-36 months for benzoates (2%) and BHA (1%), and by the age group 7-12 months (16%) and 13-36 months (58%) for nitrites. Measured concentration data were available exclusively for nitrites and the results obtained using these data showed that the nitrites' intake was below the ADI for all the population considered in this study. These results suggest that refinement of exposure, based on the assessment of food levels, is needed to estimate the exposure of children to BHA and benzoates for which the risk of exceeding the ADI cannot be excluded when using occurrence data. PMID:25686474

  19. Decree of the State Office for Nuclear Safety No. 219/1997 of 22 August 1997 specifying details for emergency preparedness of nuclear facilities and workplaces handling ionizing radiation sources and specifying requirements for the contents of internal emergency plans and emergency rules

    International Nuclear Information System (INIS)

    The Decree addresses the following issues: definition of a radiological event and interventions to be accomplished if a radiological event takes place; emergency preparedness; establishing a radiological event; assessment of a radiological event; warnings, notifications and alarms during a radiological event; intervention - management, procedures, instructions; radiological situation monitoring programme; provisions to restrict human exposure; health care provisions; documentation; informing the State Office for Nuclear Safety; personnel instructions and training; emergency preparedness inspection; internal emergency plan; emergency rules; and related issues. (P.A.)

  20. Dicty_cDB: Contig-U06096-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available |||||||||||| Sbjct: 64 gaaatngatgntncaacnccaacaatggctgcaaanattttttnnccnttttcaattggt 123 Query: 124 ggnaatgttggngatgntacaacnccna...ctt 154 ||||||||||||||||||||||||||||||| Sbjct: 124 ggnaatgttggngatgntacaacnccnactt 154 Sc...us Query: 219 atcncaacnatnncaacaacnaactgaatcagaattacnaccnattcaaa 268 |||||||||||||||||||||||||||||||||||||||...||||||||||| Sbjct: 219 atcncaacnatnncaacaacnaactgaatcagaattacnaccnattcaaa 268 >Contig-U11917-1 (Contig-U1191...atgntncaacnccaacaatggctgcaaanattttttnnccnttttcaattggt 147 Query: 124 ggnaatgttggngatgntacaacnccnacttnaaaanaa

  1. Drug: D01883 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D01883 Drug Aniracetam (JAN/USAN/INN) C12H13NO3 219.0895 219.2365 D01883.gif Mental performance ... OANALEPTICS N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD ... AND NOOTROPICS N06BX Other psychostimulants and no ...

  2. 75 FR 65439 - Defense Federal Acquisition Regulation Supplement; Electronic Subcontracting Reporting System

    Science.gov (United States)

    2010-10-25

    ... contracts that meet the requirements of Section 211 of Public Law 95-507. (c) The Contractor shall-- (1..., rather than Standard Form 294--Subcontract Report for Individual Contracts, and Standard Form 295.... Section 219.708 is amended by revising paragraph (b)(1) to read as follows: 219.708 Contract clauses....

  3. EST Table: BY937615 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available BY937615 E_FL_e100_02B06_F_0 10/09/28 88 %/219 aa gb|EEZ97711.1| Ras opposite [Trib... aa gnl|Amel|GB12540-PA 10/09/10 88 %/219 aa gi|270001264|gb|EEZ97711.1| Ras opposite [Tribolium castaneum] FS768412 e100 ...

  4. Improving quality of care among COPD outpatients in Denmark 2008-2011

    DEFF Research Database (Denmark)

    Tøttenborg, Sandra Søgaard; Lange, P.; Thomsen, R.W.; Nielsen, Henrik; Johnsen, S.P.; Frausing Hansen, E.

    2013-01-01

    % for all indicators. Compared to 2008, a higher proportion of COPD outpatients in 2011 received annual measurements of the forced expiratory volume in one second in percent of predicted (FEV1% predicted) (RR 2.14, 95% CI, 2.09; 2.19), assessment of BMI (RR 2.24, 95% CI, 2.19; 2.29), assessment of...

  5. Functional design criteria radioactive liquid waste line replacement, Project W-087. Revision 3

    International Nuclear Information System (INIS)

    This document provides the functional design criteria for the 222-S Laboratory radioactive waste drain piping and transfer pipeline replacement. The project will replace the radioactive waste drain piping from the hot cells in 222-S to the 219-S Waste Handling Facility and provide a new waste transfer route from 219-S to the 244-S Catch Station in Tank Farms

  6. Frekventni odziv turbulentnog osnosimetriчnog mlaza vazduha na modifikaцijy zvuчnim osцilaцijama iz spoљaшњeg izvora pobude

    Czech Academy of Sciences Publication Activity Database

    Cvetinović, D.; Čantrak, S.; Tihon, Jaroslav; Drahoš, Jiří

    205-219, 3-4 (2009), s. 205-219. ISBN 0350-218X Institutional research plan: CEZ:AV0Z40720504 Keywords : turbulent axisymmetric jet * acoustic oscillations modi fication * impinging jet heat transfer Subject RIV: CI - Industrial Chemistry, Chemical Engineering

  7. 77 FR 76936 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

    Science.gov (United States)

    2012-12-31

    ..., Contractor Code of Business Ethics and Conduct, is the DoD Office of Inspector General at the following...'' and adding ``datafax (571) 372-6094'' in its place. PART 203--IMPROPER BUSINESS PRACTICES AND PERSONAL.../ CPF'' and adding ``DPAP/CPIC'' in its place. PART 219--SMALL BUSINESS PROGRAMS 219.202-1 0 8....

  8. 26 CFR 1.806-3 - Certain changes in reserves and assets.

    Science.gov (United States)

    2010-04-01

    ... assets were held, the numerator shall be the number of days during the taxable year which such reserves... the transfer. In computing the period held for purposes of the numerator, the day on which such... October 19, 1958, $70,000 ($64,000+$76,000=$140,000÷2) by the fraction 219/365 (the numerator of 219...

  9. Curing of the 2 mu DNA plasmid from Saccharomyces cerevisiae.

    OpenAIRE

    Toh-e, A; Wickner, R B

    1981-01-01

    The 2 mu DNA plasmid is often eliminated from yeast cells when they are transformed with the 2 mu DNA-LEU2-pMB9 composite plasmid pJDB219. Since pJDB219 is subsequently lost with high frequency, derivatives lacking all 2 mu DNA can be prepared from any strain.

  10. Modélisation pluie-débit en région tropicale humide : application des réseaux de neurones sur quatre stations hydrométriques du Bandama Blanc (Bada, Marabadiassa, Tortiya et Bou situées au Nord de la Côte d'Ivoire. Thèse de l'Université de Cocody (Côte d'Ivoire, 2007, 219 p.

    Directory of Open Access Journals (Sweden)

    Yao Blaise Koffi

    2009-12-01

    Full Text Available La relation pluie-débit fait l'objet de nombreuses études, à cause de son importance dans la mise en œuvre de nombreux projets de développement. La communauté scientifique, dans le souci de faire face aux problèmes d'eau, tels que les inondations et les sècheresses, utilise différents modèles. Mais ces modèles sont généralement confrontés à la non-linéarité de la relation pluie-débit. Dans le cas du Bandama Blanc, objet de cette étude, cette non-linéarité est accentuée par la présence de plusieurs barrages à vocation agro-pastorale situés dans la partie nord de la zone d'étude et qui utilisent les eaux de ce fleuve. Ce mémoire de thèse traite donc de la modélisation des débits mensuels du Bandama Blanc, aux stations de Bada, Marabadiassa, Tortiya et Bou, à l'aide des réseaux de neurones, déjà éprouvés dans ce contexte de relation non-linéaire. Elle projette de fournir des outils plus robustes aux hydrologues africains pour la simulation et la prévision des débits des rivières jaugées. Pour atteindre cet objectif, deux Perceptrons Multicouches entraînés avec l'algorithme de la rétropropagation de l'erreur ont été construits. Le premier modèle a été utilisé seulement en simulation et le second en simulation et en prévision. Le modèle conceptuel GR2M, a été utilisé pour valider les résultats obtenus avec les réseaux de neurones. Pour cette étude, une importante base de données climatiques (pluie et température et hydrométriques (débits mensuels a été utilisée. Les résultats obtenus sont forts satisfaisants et nettement supérieurs à ceux obtenus avec le modèle conceptuel global GR2M. En effet, les réseaux de neurones parviennent à expliquer plus de 70 % de la variation des débits, avec des coefficients de corrélation de Pearson qui excèdent 0,80. Cependant ces modèles arrivent difficilement à simuler et à faire la prévision des débits extrêmes (étiages et crues, à cause probablement du nombre réduit de données à notre disposition et de la séparation des bases de calage et de validation.The rainfall-runoff relationship is the subject of many studies because of its importance in the implementation of many development projects. The scientific community, in order to cope with water problems such as floods and droughts, used different models. But these models are usually faced with the non-linearity of the rainfall-runoff relationship. In the case of the Bandama Blanc purpose of this study, this non-linearity is enhanced by the presence of several agro-pastoral dams located in the northern part of the study area and using the waters of this river. This thesis therefore deals with the modeling of flows of Bandama Blanc hydrometric stations (Bada Marabadiassa, Tortiya and Bou using neural networks already experienced in the context of non-linear relationship. It plans to provide more robust tools to African hydrologist in the simulation and forecasting of river flows. To achieve this goal, two Multilayer Perceptrons trained with the backpropagation algorithm of error have been built. The first model was used only in simulation and the second in simulation and prediction. The conceptual model GR2M was used to validate the results obtained with neural networks. An extensive database climate (rainfall and temperature and river monthly flow was used in this study. The results obtained are very satisfactory and well above those obtained with the overall conceptual model GR2M. Indeed, neural networks are able to explain more than 70% of the variation in rates, with Pearson correlation coefficients exceeding 0.80. However, these models have difficulty to simulate and predict extremes flow probably because of the reduced number of data at our disposal and separation of bases calibration and validation.

  11. Source identification in two criminal cases using phylogenetic analysis of HIV-1 DNA sequences.

    Science.gov (United States)

    Scaduto, Diane I; Brown, Jeremy M; Haaland, Wade C; Zwickl, Derrick J; Hillis, David M; Metzker, Michael L

    2010-12-14

    Phylogenetic analysis has been widely used to test the a priori hypothesis of epidemiological clustering in suspected transmission chains of HIV-1. Among studies showing strong support for relatedness between HIV samples obtained from infected individuals, evidence for the direction of transmission between epidemiologically related pairs has been lacking. During transmission of HIV, a genetic bottleneck occurs, resulting in the paraphyly of source viruses with respect to those of the recipient. This paraphyly establishes the direction of transmission, from which the source can then be inferred. Here, we present methods and results from two criminal cases, State of Washington v Anthony Eugene Whitfield, case number 04-1-0617-5 (Superior Court of the State of Washington, Thurston County, 2004) and State of Texas v Philippe Padieu, case numbers 219-82276-07, 219-82277-07, 219-82278-07, 219-82279-07, 219-82280-07, and 219-82705-07 (219th Judicial District Court, Collin County, TX, 2009), which provided evidence that direction can be established from blinded case samples. The observed paraphyly from each case study led to the identification of an inferred source (i.e., index case), whose identity was revealed at trial to be that of the defendant. PMID:21078965

  12. EFFECT OF MECHANICAL PROPERTIES OF MARTENSITE AND LOADING RATE ON DUAL PHASE STEELS

    Directory of Open Access Journals (Sweden)

    Ali BAYRAM

    1998-03-01

    Full Text Available In this study, steel sheet materials were used in order to obtain dual-phase steel. Specimens for this purpose have been annealed in ferrite + astatine regions at the temperatures of 740, 760, 800 and 820 °C. The specimens were annealed at the different temperatures with corresponding times 20, 40 and 60 minutes and quenched into water. As a result of this dual-phase steels at different ferrite + martensite ratio were produced. Sheet specimens were tested at the range of loading rates of 10, 50 and 259 mm/min. Strength properties of dual-phase steels were investigated depending on annealing temperature, ratio of martensite and loading rate.

  13. A route for polonium 210 production from alpha-particle irradiated bismuth-209 target

    International Nuclear Information System (INIS)

    A method is proposed for production of polonium-210 via the 209Bi(α,3n)210 At nuclear reaction. Bombardment of a bismuth-209 target was performed with a 37 MeV alpha-particle beam that leads to the production of astatine-210 (T1/2 = 8.1 h), which decays to polonium-210. It is purified from the bismuth target matrix by employing liquid-liquid extraction using tributyl phosphate (TBP) in para-xylene from 7 M hydrochloric acid. Back extraction of polonium-210 was performed by 9 M nitric acid. This method allows to purify a tracer amount of Po-210 (2.6 x 10-13 mol) from macroscopic amount of Bi (2.8 x 10-2 mol).

  14. Effective bond orders from two-step spin–orbit coupling approaches: The I{sub 2}, At{sub 2}, IO{sup +}, and AtO{sup +} case studies

    Energy Technology Data Exchange (ETDEWEB)

    Maurice, Rémi, E-mail: remi.maurice@subatech.in2p3.fr; Montavon, Gilles [SUBATECH, CNRS UMR 6457, IN2P3/EMN Nantes/Université de Nantes, 4 rue Alfred Kastler, BP 20722, 44307 Nantes Cedex 3 (France); Réal, Florent; Gomes, André Severo Pereira; Vallet, Valérie [Laboratoire PhLAM, CNRS UMR 8523, Université de Lille, 59655 Villeneuve d’Ascq Cedex (France); Galland, Nicolas [CEISAM, UMR CNRS 6230, Université de Nantes, 2 rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3 (France)

    2015-03-07

    The nature of chemical bonds in heavy main-group diatomics is discussed from the viewpoint of effective bond orders, which are computed from spin–orbit wave functions resulting from spin–orbit configuration interaction calculations. The reliability of the relativistic correlated wave functions obtained in such two-step spin–orbit coupling frameworks is assessed by benchmark studies of the spectroscopic constants with respect to either experimental data, or state-of-the-art fully relativistic correlated calculations. The I{sub 2}, At{sub 2}, IO{sup +}, and AtO{sup +} species are considered, and differences and similarities between the astatine and iodine elements are highlighted. In particular, we demonstrate that spin–orbit coupling weakens the covalent character of the bond in At{sub 2} even more than electron correlation, making the consideration of spin–orbit coupling compulsory for discussing chemical bonding in heavy (6p) main group element systems.

  15. Effective bond orders from two-step spin–orbit coupling approaches: The I2, At2, IO+, and AtO+ case studies

    International Nuclear Information System (INIS)

    The nature of chemical bonds in heavy main-group diatomics is discussed from the viewpoint of effective bond orders, which are computed from spin–orbit wave functions resulting from spin–orbit configuration interaction calculations. The reliability of the relativistic correlated wave functions obtained in such two-step spin–orbit coupling frameworks is assessed by benchmark studies of the spectroscopic constants with respect to either experimental data, or state-of-the-art fully relativistic correlated calculations. The I2, At2, IO+, and AtO+ species are considered, and differences and similarities between the astatine and iodine elements are highlighted. In particular, we demonstrate that spin–orbit coupling weakens the covalent character of the bond in At2 even more than electron correlation, making the consideration of spin–orbit coupling compulsory for discussing chemical bonding in heavy (6p) main group element systems

  16. Different ways to improve the clinical effectiveness of radioimmunotherapy in solid tumors

    Directory of Open Access Journals (Sweden)

    Chatal Jean-Francois

    2009-09-01

    Full Text Available Radioimmunotherapy (RIT has been proven effective in the treatment of radiosensitive non-Hodgkin lymphoma but, for radioresistant solid tumors, new approaches are necessary to improve the clinical effectiveness. A real improvement has been the introduction of the pretargeting technology which appeared to be able to significantly increase tumor-to-normal organ uptake ratios.Another very promising approach consists in associating RIT with other treatment modalities. Finally the use of alpha particle-emitting radionuclides such as astatin-211 or bismuth-213 (alpha-RIT should allow to efficiently eradicate disseminated microscopic clusters of tumor cells or isolated tumor cells which fit well with the short path length of alpha particles.

  17. Sequential radioimmunotherapy with 177Lu- and 211At-labeled monoclonal antibody BR96 in a syngeneic rat colon carcinoma model

    DEFF Research Database (Denmark)

    Eriksson, Sophie E; Elgström, Erika; Bäck, Tom;

    2014-01-01

    UNLABELLED: Alpha-particle emitters, such as astatine-211 (211At), are generally considered suitable for the treatment of small cell clusters due to their short path length, while beta-particle emitters, for example, Lutetium-177 (177Lu), have a longer path length and are considered better for...... small, established tumors. A combination of such radionuclides may be successful in regimens of radioimmunotherapy. In this study, rats were treated by sequential administration of first a 177Lu-labeled antibody, followed by a 211At-labeled antibody 25 days later. METHODS: Rats bearing solid colon...... carcinoma tumors were treated with 400 MBq/kg body weight 177Lu-BR96. After 25 days, three groups of animals were given either 5 or 10 MBq/kg body weight of 211At-BR96 simultaneously with or without a blocking agent reducing halogen uptake in normal tissues. Control animals were not given any 211At-BR96...

  18. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    CERN Document Server

    Marsh, B A; Imai, N; Seliverstov, M D; Rothe, S; Sels, S; Capponi, L; Rossel, R E; Franchoo, S; Wendt, K; Focker, G J; Kalaninova, Z; Sjoedin, A M; Popescu, L; Nicol, T; Huyse, M; Radulov, D; Atanasov, D; Kesteloot, N; Borgmann, Ch; Cocolios, T E; Lecesne, N; Ghys, L; Pauwels, D; Rapisarda, E; Kreim, S; Liberati, V; Wolf, R N; Andel, B; Schweikhard, L; Lane, J; Derkx, X; Kudryavtsev, Yu; Zemlyanoy, S G; Fedosseev, V N; Lynch, K M; Rosenbusch, M; Van Duppen, P; Lunney, D; Manea, V; Barzakh, A E; Andreyev, A N; Truesdale, V; Flanagan, K T; Molkanov, P L; Koester, U; Van Beveren, C; Wienholtz, F; Goodacre, T Day; Antalic, S; Bastin, B; De Witte, H; Fink, D A; Fedorov, D V

    2013-01-01

    At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar fr...

  19. Development of 211At Chemistry for Labelling Biomolecules

    International Nuclear Information System (INIS)

    Our studies have demonstrated that high recovery of 211At can be obtained using a “wet chemistry” approach to isolation from the bismuth target. We have also demonstrated that direct labelling of antibody-B10 conjugates with 211At can be performed in high yields, and that the astatinated antibodies are stable to in vivo deastatination. While these results will allow us to enter clinical studies with 211At-labelled antibodies, the chemistry associated with 211At is not fully understood. Therefore, it is important that many more basic studies to be conducted with 211At, so the optimal labelling reagent for each type of disease-targeting agent becomes apparent

  20. Alpha particle induced DNA damage and repair in normal cultured thyrocytes of different proliferation status

    DEFF Research Database (Denmark)

    Lyckesvärd, Madeleine Nordén; Delle, Ulla; Kahu, Helena;

    2014-01-01

    Childhood exposure to ionizing radiation increases the risk of developing thyroid cancer later in life and this is suggested to be due to higher proliferation of the young thyroid. The interest of using high-LET alpha particles from Astatine-211 ((211)At), concentrated in the thyroid by the same...... levels of γH2AX decreased during the first 24h in both cycling and stationary cultures and complete repair was seen in all cultures but cycling cells exposed to (211)At. Compared to stationary cells alpha particles were more harmful for cycling cultures, an effect also seen at the pChk2 levels...... cultures at a modest level of damage, clearly demonstrating that cell cycle status influences the relative effectiveness of alpha particles....

  1. An improved synthesis of an 125I and 211At labelled benzamide for melanoma imaging

    International Nuclear Information System (INIS)

    Recent studies have indicated that benzamides can exhibit affinity for malignant melanoma and may be exploited diagnostically in the treatment of this cancer. Radioiodinated N-(2-diethylaminoethyl)-3-[123I/131I]iodo-4-methoxybenzamide (*I-IMBA) is a benzamide with promising diagnostic properties. A new synthesis procedure was developed to obtain 125I-IMBA suitable for use in vivo. The assets of the procedure include the use of less toxic reagents and better reproducible results when radiolabelling the precursor. The procedure also facilitates the synthesis of the astatinated N-(2-diethylaminoethyl)-3-[211At]astatine-4-methoxybenzamide (211At-AMBA), a new benzamide with a therapeutic potential. The regiospecific no-carrier-added 125I- and 211At-labeling of the benzamide is performed by demetalation of an organotin precursor. Using tributylstannyl as a leaving group, the radiochemical yield obtained after 15 minutes of reaction was 70 %-90 % for both 125I-IMBA and 211At-AMBA. The labelling was performed in a solution of MeOH:AcOH with NCS as the oxidising agent. The organotin precursor N-(2-diethylaminoethyl)-3-(tri-n-butylstannyl)-4-methoxy-benzamide was synthesized from 3-bromo-4-methoxybenzoic acid, with n-BuLi (2 eq) and Bu3SnCl (1 eq) in THF, giving 3-(tri-n-butylstannyl)-4-methoxybenzoic acid. The amide function was introduced by converting the acid group into an active N-succinimidyl-ester, a good leaving group in the reaction with 2-(diethylamino)ethylamine. The overall yield of the organotin precursor was 65 %

  2. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    Energy Technology Data Exchange (ETDEWEB)

    Marsh, B.A., E-mail: bruce.marsh@cern.ch [CERN, CH-1211 Geneva (Switzerland); Andel, B. [Comenius University, Bratislava (Slovakia); Andreyev, A.N. [University of York, Department of Physics, York YO10 5DD (United Kingdom); Antalic, S. [Comenius University, Bratislava (Slovakia); Atanasov, D. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Barzakh, A.E. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Bastin, B. [Grand Accérateur National d’Ions Lourds (GANIL), Bd Henri Becquerel, F-14076 Caen (France); Borgmann, Ch. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Capponi, L. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Cocolios, T.E.; Day Goodacre, T. [CERN, CH-1211 Geneva (Switzerland); University of Manchester, Manchester (United Kingdom); Dehairs, M. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Derkx, X. [University of the West of Scotland, School of Engineering, Paisley PA1 2BE (United Kingdom); De Witte, H. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Fedorov, D.V. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Fedosseev, V.N.; Focker, G.J. [CERN, CH-1211 Geneva (Switzerland); Fink, D.A. [Ruprecht-Karls Universität, Seminarstr. 2, 69117 Heidelberg (Germany); CERN, CH-1211 Geneva (Switzerland); Flanagan, K.T. [University of Manchester, Manchester (United Kingdom); Franchoo, S. [CSNSM-IN2P3-CNRS, Université Paris-Sud, 91406 Orsay (France); and others

    2013-12-15

    Highlights: • Upgrade of the lasers, detectors and data acquisition for in-source resonance ionization spectroscopy at ISOLDE. • First use of the ISOLTRAP MR-ToF MS in combination with laser spectroscopy at ISOLDE. • Resonance ionization of astatine for the study of its nuclear structure. -- Abstract: At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar free ionization using the Laser Ion Source Trap, LIST (Po); isobar selective particle identification using the multi-reflection time-of-flight mass separator (MR-ToF MS) of ISOLTRAP (Au, At). These are summarized as part of an overview of the current status of the in-source resonance ionization spectroscopy setup at ISOLDE.

  3. Dicty_cDB: Contig-U14270-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available |||||||||| Sbjct: 191 gttcaacacaatgcngntcngcaacatgctganccagntgccaagccagccgaattaacc 250 Query: 251 natgcccnagaattncaacaagaacaccna...||||||| Sbjct: 251 natgcccnagaattncaacaagaacaccnaagncaagnagctctcgcaaaacnncnngct 3...10 Query: 311 cgtattagncaacaaaatcntgtcaaacaagcngcccnanagaaacgaacctcgcnacgt 370 |||||||||||||||||||||||||||||...||||||||||||||||||||||||||||||| Sbjct: 311 cgtattagncaacaaaatcntgtcaaacaagcngcccnanagaaacgaacctcgcnacgt 370 ...ct: 219 cngctgctcngggggctgccaanccagttcaacacaatgcngntcngcaacatgctganc 160 Query: 225 cagntgccaagccagccgaattaaccnatgcccna

  4. 50 CFR Table 2d to Part 679 - Species Codes-Non-FMP Species

    Science.gov (United States)

    2010-10-01

    ... 220 Pacific tomcod 250 Poacher (Family Agonidae) 219 Prowfish 215 Ratfish 714 Rockfish, black (GOA) 142 Rockfish, blue (GOA) 167 Rockfish, dark 173 Sardine, Pacific (pilchard) 170 Sea cucumber, red...

  5. Drug: D03362 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D03362 Drug Trafermin (genetical recombination) (JAN); Trafermin (USAN/INN); Fiblast (TN) C764H1 ... 201N217O219S6 17111.7836 17122.4232 Stroke ... treatment; Fibroblast growth factor Therapeutic ca ...

  6. Oscillation and nonoscillation criteria for half-linear second order differential equations

    Czech Academy of Sciences Publication Activity Database

    Došlý, O.; Lomtatidze, Alexander

    2006-01-01

    Roč. 36, č. 2 (2006), s. 203-219. ISSN 0018-2079 Institutional research plan: CEZ:AV0Z10190503 Keywords : half-linear equation s * generalized Euler Equation * principal solution Subject RIV: BA - General Mathematics

  7. Comparison of the Chromosome Banding Pattern in the 2n = 5 6 Cytotypes of Nannospalax leucodon and N. xanthodon from Turkey

    Czech Academy of Sciences Publication Activity Database

    Arslan, A.; Arisoy, A.; Zima, Jan

    2014-01-01

    Roč. 2014, č. 121690 (2014), s. 121690. ISSN 1537-744X Institutional support: RVO:68081766 Keywords : mole rats * karyotype characteristics Subject RIV: EG - Zoology Impact factor: 1.219, year: 2013

  8. Doctoral Theses in Library and Information Science Completed in Indian Universities, 2001-2007

    Science.gov (United States)

    Mestri, D. D.

    2008-01-01

    Provides a complete listing and analysis of 219 doctoral theses submitted to the departments of library and information science (DLIS) in 45 Indian universities between January 2001 and December 2007. (Contains 10 tables.)

  9. Optimal Mirrleesean taxation in a Ben-Porath economy

    Czech Academy of Sciences Publication Activity Database

    Kapička, Marek

    2015-01-01

    Roč. 7, č. 2 (2015), s. 219-248. ISSN 1945-7707 Institutional support: RVO:67985998 Keywords : optimal taxes * unobservable human capital * income taxes Subject RIV: AH - Economics Impact factor: 3.780, year: 2014

  10. An exploratory study of the interaction of cognitive complexity, dogmatism, and repression-sensitization among college students

    Science.gov (United States)

    Starbird, Dannel H.; Biller, Henry B.

    1976-01-01

    A total of 219 male and female college students returned questionnaire measures relating to cognitive complexity, dogmatism, and repression-sensitization. Analyses revealed very complex interactions among the variables. (Author/SB)

  11. Dicty_cDB: SLA529 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 1999. 2.19 Translated Amino Acid sequence ffffffffffl*lattakynkpkrt*isskillfs*avsltnsltapaslpaf*eiskdi gvve...quence (All Frames) Frame A: ffffffffffl*lattakynkpkrt*isskillfs*avsltnsltapaslpaf*eiskdi gvveervipkfadsftks

  12. Comeniana aus dem Nachlass von Dietrich Mahnke. Die Korrespondenz zwischen Dietrich Mahnke und Dmitrij Tschižewskij aus dem Jahre 1935. Beilage: die Korrespondenz

    Czech Academy of Sciences Publication Activity Database

    Schifferová, Věra

    18/42/, - (2004), s. 219-223. ISSN 0231-5955 Institutional research plan: CEZ:AV0Z9009908 Keywords : The interpretation of Comenius * the pupils of Edmund Husserl * rationalism and mysticism Subject RIV: AA - Philosophy ; Religion

  13. Viability of Basidiomycete Strains after Cryopreservation: Compatison of Ewo Different Freezing Protocols

    Czech Academy of Sciences Publication Activity Database

    Homolka, Ladislav; Lisá, Ludmila; Nerud, František

    2003-01-01

    Roč. 48, č. 2 (2003), s. 219-226. ISSN 0015-5632 Institutional research plan: CEZ:AV0Z5020903 Keywords : basidiomycete strains * culture Subject RIV: EE - Microbiology, Virology Impact factor: 0.857, year: 2003

  14. Novel biophysical determination of miRNAs related to prostate and head and neck cancers

    Czech Academy of Sciences Publication Activity Database

    Hudcová, K.; Trnková, L.; Kejnovská, Iva; Vorlíčková, Michaela; Gumulec, J.; Kizek, R.; Masarik, M.

    2015-01-01

    Roč. 44, č. 3 (2015), s. 131-138. ISSN 0175-7571 Institutional support: RVO:68081707 Keywords : SQUAMOUS-CELL CARCINOMA * ELIMINATION VOLTAMMETRY * CYTOSINE SIGNALS Subject RIV: BO - Biophysics Impact factor: 2.219, year: 2014

  15. On Development of Medical Informatics Education via European Cooperation

    Czech Academy of Sciences Publication Activity Database

    Zvárová, Jana

    1998-01-01

    Roč. 50, - (1998), s. 219-223. ISSN 1386-5056 Keywords : information technologies * education * training * medical informatics * medical statistics * epidemiology Subject RIV: BB - Applied Statistics, Operational Research Impact factor: 0.357, year: 1998

  16. Gene : CBRC-ACAR-01-0376 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available 219.3| AGAP008244-PA [Anopheles gambiae str. PEST] gb|EAL39610.3| AGAP008244-PA [Anopheles gambiae str. PEST] 1e-143 37% MTIAGTSES...TGVQESTSPETTTAATTESTRAQETTSRDSTTASTSQTTVVQETTSPEGTTAATSEFPNAQETTSPESAKATSSQSTILSETTSPEGTIAGTSES...PRAQETTSLKSTKTPTSESTTLSETTSLERTIEGISESTVVQETTSLETTTAATTLSSRAQEITSPESTKIPTSESTTLSETTSSES...AMSATTESPRAQETTSPDITTAATSESTTLSEKTSPESTIAGTSQSTVVQETTSPEGTIAATSESPKAQETTSPESTKTAASESTPLPKTVSPESTITGRSES...TIVQETTSPDGTTAATSESTVVQETTSPESTTAATSESPRAQETTSPESTTAATPESSKLSETTSPESTIAGTSQSTVVQETTSPDSTTAATSESQRAHKTTSPESTKTAKSES

  17. U.S. Health Report Card Finds Racial, Ethnic Disparities Persist

    Science.gov (United States)

    ... percent in 2014). Childhood obesity rates varied widely, too. Hispanics ages 2 to 19 had the highest rate of obesity (21.9 percent) between 2011 and 2014 while Asians had the lowest rate (8.6 percent). Hispanic ...

  18. An open-label study to assess the effect of a single dose of Nebivolol and Ivabradine on heart rate and pulse wave velocity in hypertensive patients receiving amlodipine

    Directory of Open Access Journals (Sweden)

    Rama Mohan Pathapati

    2015-04-01

    Conclusions: Nebivolol is an effective HR lowering agent compared to Ivabradine. However, significant decrease in arterial stiffness was observed with Ivabradine. [Int J Basic Clin Pharmacol 2015; 4(2.000: 219-223

  19. Alternative models of entrance exams and access to higher education: the case of the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Konečný, Tomáš; Basl, J.; Mysliveček, Jan; Simonová, N.

    2012-01-01

    Roč. 63, č. 2 (2012), s. 219-235. ISSN 0018-1560 Institutional support: PRVOUK-P23 Keywords : higher education * admission exams * educational equity Subject RIV: AO - Sociology, Demography Impact factor: 0.937, year: 2012

  20. Evolutionary history of tree squirrels (Rodentia, Sciurini) based on multilocus phylogeny reconstruction

    Czech Academy of Sciences Publication Activity Database

    Pečnerová, P.; Martínková, Natália

    2012-01-01

    Roč. 41, č. 3 (2012), s. 211-219. ISSN 0300-3256 Institutional research plan: CEZ:AV0Z60930519 Keywords : phylogeny * Sciurus * biogeography * colonisation Subject RIV: EG - Zoology Impact factor: 2.793, year: 2012

  1. 22 CFR 1203.735-216 - Miscellaneous statutory provisions.

    Science.gov (United States)

    2010-04-01

    ... Government (18 U.S.C. 285). (15) The prohibition against political activities in subchapter III of chapter 73... (18 U.S.C. 219). (17) The prohibition against discrimination because of politics, race, religion,...

  2. Varianty Gellnerovy komedie Přístav manželství jako rozcestník jeho tvorby

    Czech Academy of Sciences Publication Activity Database

    Peisertová, Lucie

    2012-01-01

    Roč. 44, č. 2012 (2012), s. 201-219. ISSN 0231-5904 Institutional support: RVO:68378068 Keywords : Czech drama * Gellner, František * text ual criticism Subject RIV: AJ - Letters, Mass-media, Audiovision

  3. Microseismic monitoring in early Haynesville development

    Czech Academy of Sciences Publication Activity Database

    Duncan, P.M.; Barker, W.B.; Eisner, Leo; Smith, P.G.; Smith, K.; Williams-Stroud, S.

    Tulsa: AAPG, 2013 - (Hammes, U.; Gale, J.), s. 219-236. (AAPG Memoir. 105). ISBN 9780891813859 Institutional support: RVO:67985891 Keywords : microseismicity * shale gas * Haynesville Subject RIV: DC - Siesmology, Volcanology, Earth Structure

  4. Medline Plus

    Full Text Available ... Flash Player for free at www.adobe.com/products/flashplayer . The videos open in a second window. ... Angioplasty Stent Placement (Shawnee Mission Medical Center, Merriam, KS, 2/19/ ...

  5. Plant species richness-productivity relationships in a low-productive boreal region

    Czech Academy of Sciences Publication Activity Database

    Axmanová, I.; Chytrý, M.; Danihelka, Jiří; Lustyk, P.; Kočí, M.; Kubešová, S.; Horsák, M.; Cherosov, M. M.; Gogoleva, P. A.

    2013-01-01

    Roč. 214, č. 2 (2013), s. 207-219. ISSN 1385-0237 Institutional support: RVO:67985939 Keywords : competitive excluison * forest herb layer * grassland Subject RIV: EF - Botanics Impact factor: 1.640, year: 2013

  6. Prevalence of gestational diabetes mellitus, its associated risk factors and pregnancy outcomes at a rural setup in Central India

    Directory of Open Access Journals (Sweden)

    Kanika R. Kalyani

    2014-02-01

    Conclusion: GDM adversely affects maternal and fetal outcomes and its prevalence is steadily rising. Appropriate interventions are required for its control. [Int J Reprod Contracept Obstet Gynecol 2014; 3(1.000: 219-224

  7. EST data: 5872 [RED

    Lifescience Database Archive (English)

    Full Text Available RA0286 D23831 AU164531 DPlate 061 H02 TCGTGCACGCCGACGCGGTC TTGGTGAGGAAGTTGGCCTC >AC002329_18(AC0 ... nucleotide-disulphide oxidoreductases located from residues ... 197 to 219 [CAVCD...IGGGD]. ...

  8. EST data: 5857 [RED

    Lifescience Database Archive (English)

    Full Text Available RA0132 D23778 DPlate 061 A01 GCCGACCTCATGGACCGCTG GGTTCCAGAATGCGTCGGAG >AC002329_18(AC002329|pid ... nucleotide-disulphide oxidoreductases located from residues ... 197 to 219 [CAVCD...IGGGD]. ...

  9. Drug: D09952 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available ACE VTHQGLSSPV TKSFNRGEC (Disulfide bridge: 23-93; 139-199; H130-L219, Dimer) Peptide Treatment of Alzheim...er's disease monoclonal antibody beta-amyloid CAS: 1178862-65-1 PubChem: 124490631 ...

  10. Explanatory Style of Secondary Vocational Educators.

    Science.gov (United States)

    Hall, Helen C.; Smith, Bettye P.

    1999-01-01

    A study of the explanatory style of secondary vocational education in Georgia (n=219) indicated that most had an optimistic explanatory style. Business teachers were most likely and agriculture teachers least likely to use this style. (JOW)

  11. Red Pericarp Advanced Breeding Lines Derived from Oryza rufipogon × Oryza sativa: Physicochemical Properties, Total Antioxidant Activity, Phenolic Compounds and Vitamin E Content

    OpenAIRE

    Parviz Fasahat; Aminah Abdullah; Kharidah Muhammad; Tilakavati Karupaiah; Wickneswari Ratnam

    2012-01-01

    Two new red pericarp transgressive variants (advanced breeding lines from BC2F7 generation) with high yield, derived from a cross between the wild relative, O. rufipogon Griff. and O. sativa subsp. indica cv. MR219, were analysed to determine their proximate composition, total antioxidant activity, phenolic acid composition and tocochromanol content in comparison with two commonly consumed rice varieties, MR219 (brown coloured) and Thailand rice (red coloured). The red pericarp variants were ...

  12. Longitudinal view of the psychological correlates and antecedents of subjectively assessed psychosomatic problems

    Czech Academy of Sciences Publication Activity Database

    Slezáčková, Alena; Blatný, Marek; Millová, Katarína; Jelínek, Martin

    2011-01-01

    Roč. 26, č. 2 (2011), s. 219-219. ISSN 0887-0446. [European Health Psychology Conference: Engaging with Other Health Professions: Challenges and Perspectives /25./. 20.09.2011-24.09.2011, Hersonissos, Kréta] R&D Projects: GA ČR GAP407/10/2410 Institutional research plan: CEZ:AV0Z70250504 Keywords : psychosomatic problems * middle adulthood * subjectively assessed health Subject RIV: AN - Psychology

  13. Domain Modeling: NP_872414.2 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_872414.2 chr12 Crystal structure of a human Notch1 ankyrin domain mutant p2qc9b_ chr12/NP_872414.2.../NP_872414.2_apo_18-219.pdb p2he0a_ chr12/NP_872414.2/NP_872414.2_holo_18-219.pdb psi-blast 305L,306D,307H,308L,309V,340K EDO 1 ...

  14. Drug: D05274 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D05274 Drug Ornidazole (USAN/INN) C7H10ClN3O3 219.0411 219.6256 D05274.gif Anti-infective ATC co ... ICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS G01AF Imidazole ... derivatives G01AF06 Ornidazole D05274 Ornidazole ( ... S FOR SYSTEMIC USE J01X OTHER ANTIBACTERIALS J01XD Imidazole ... derivatives J01XD03 Ornidazole D05274 Ornidazole ( ...

  15. Isolation and characterization of a novel endoglucanase from a Bursaphelenchus xylophilus metagenomic library.

    Directory of Open Access Journals (Sweden)

    Lin Zhang

    Full Text Available A novel gene (designated as cen219 encoding endoglucanase was isolated from a Bursaphelenchus xylophilus metagenomic library by functional screening. Sequence analysis revealed that cen219 encoded a protein of 367 amino acids. SDS-PAGE analysis of purified endoglucanase suggested that Cen219 was a monomeric enzyme with a molecular mass of 40 kDa. The optimum temperature and pH for endoglucanase activity of Cen219 was separately 50 °C and 6.0. It was stable from 30 to 50 °C, and from pH 4.0 to 7.0. The activity was significantly enhanced by Mn(2+ and dramatically reduced by detergent SDS and metals Fe(3+, Cu(2+ or Hg(2+. The enzyme hydrolyzed a wide range of β-1, 3-, and β-1, 4-linked polysaccharides, with varying activities. Activities towards microcrystalline cellulose and filter paper were relatively high, while the highest activity was towards oat gum. The Km and Vmax of Cen219 towards CMC was 17.37 mg/ml and 333.33 U/mg, respectively. The findings have an insight into understanding the molecular basis of host-parasite interactions in B. xylophilus species. The properties also make Cen219 an interesting enzyme for biotechnological application.

  16. AcEST: BP917738 [AcEST

    Lifescience Database Archive (English)

    Full Text Available YMU001_000104_G10 219 Adiantum capillus-veneris mRNA. clone: YMU001_000104_G10. BP9177...38 CL2559Contig1 Show BP917738 Clone id YMU001_000104_G10 Library YMU01 Length 219 Definition Adiantum ca...pillus-veneris mRNA. clone: YMU001_000104_G10. Accession BP917738 Tissue type prothallium Developmental stag...s Res. 25:3389-3402. Query= BP917738|Adiantum capillus-veneris mRNA, clone: YMU001_000104_G10. (219 letters)... Res. 25:3389-3402. Query= BP917738|Adiantum capillus-veneris mRNA, clone: YMU001

  17. Elsevier收录材料科学类期刊可开放获取情况的调查与分析

    Institute of Scientific and Technical Information of China (English)

    何燕; 瞿其春; 张雪娟

    2014-01-01

    对Elsevier旗下的SDOL数据库中的219种材料科学类期刊进行有关OA方面的研究,调查发现,在OSD和DOAJ这两大OA平台上,这219种期刊的可OA情况不容乐观。在SDOL数据库中,可OA的材料科学类期刊种数为数不少,但其中可OA期刊全文的并不多。将这219种期刊区分为完全OA期刊、部分OA期刊和完全非OA期刊,并对其质量进行了对比研究,认为Elsevier中材料科学类期刊的OA情况不是十分乐观,需业界的进一步推动。

  18. Red Pericarp Advanced Breeding Lines Derived from Oryza rufipogon × Oryza sativa: Physicochemical Properties, Total Antioxidant Activity, Phenolic Compounds and Vitamin E Content

    Directory of Open Access Journals (Sweden)

    Parviz Fasahat

    2012-06-01

    Full Text Available Two new red pericarp transgressive variants (advanced breeding lines from BC2F7 generation with high yield, derived from a cross between the wild relative, O. rufipogon Griff. and O. sativa subsp. indica cv. MR219, were analysed to determine their proximate composition, total antioxidant activity, phenolic acid composition and tocochromanol content in comparison with two commonly consumed rice varieties, MR219 (brown coloured and Thailand rice (red coloured. The red pericarp variants were not significantly different in grain quality related traits. For fat content, neither variant showed any significant difference to the recurrent parent MR219, however for amylose content they possessed lower levels compared to MR219 but for both traits results were comparable to Thailand red rice. Variants G33 and G37 produced significantly (p<0.05 higher total phenolic content (0.49 and 0.51 mgGAE/g, respectively than the white control sample, MR219 (0.32 mgGAE/g but lower than Thailand red rice (1.59 mgGAE/g (p<0.05. Ferric-Reducing Ability Power (FRAP was significantly (p<0.01 higher in both variants compared to MR219 but lower than in Thailand red rice. For DPPH0 radical scavenging, both variants were not significantly different from both controls. Caffeic and ferulic acid detected in all samples were in higher amounts compared to the other compounds and hydroxycinnamic acids were considered as the main phenolic acids. Across all samples, the content of total E vitamin was higher in G37 and (-tocotrienol, which was the most abundant tocol. In conclusion both red pericarp variants can be used in cultivar development program for red rice with high nutritional value.

  19. A Study of Selected Isozymes in Capsicum baccatum, Capsicum eximium, Capsicum cardenasii and Two Interspecific F1 Hybrids in Capsicum Species

    OpenAIRE

    Ahmet Naci ONUS

    2000-01-01

    Selected isozymes were investigated in plants of Capsicum baccatum L. ( Solanaceae) accessions SA219 (P.G.Smith), Hawkes 6489 (P.G.Smith), Capsicum cardenasii Heiser and Smith accession SA268 (P.G.Smith), Capsicum eximium A.T.Hunz accession Hawkes 3860 (J.G.Hawkes) and two interspecific F1 hybrids, C. baccatum SA219 x C. eximium Hawkes 3860 and C. baccatum Hawkes 6489 x C. cardenasii SA 268. The standard technique of horizontal gel electrophoresis was employed. The gel was cut into severa...

  20. Fifth international symposium on the natural radiation environment (NRE - V). Book of abstracts

    International Nuclear Information System (INIS)

    Most of the 219 contributions Are on radon (to a much lesser extent: thoron) and its daughter products in dwellings and in the environment; on corresponding measuring instruments and - methods; on measurements done; and on radiation doses to professional workers and to the public. The section heading give a fairly good account of the subject matters treated. Measurement Techniques and Metrology (Nrs 1-33); Exposure to Natural Radiation in Non-Domestic Environments (34-56); Natural Radionuclides and Transfer Pathways (57-107); Radioactivity and Radiation in the Human Environment (108-183); Health Effects of Natural Radiation (184-205); Industrially Modified Levels of Radiation Exposure (206-219). (Quittner)

  1. AcEST: BP920795 [AcEST

    Lifescience Database Archive (English)

    Full Text Available YMU001_000141_F12 508 Adiantum capillus-veneris mRNA. clone: YMU001_000141_F12. BP920795 - Show ... 88 (47%), Gaps = 10/88 (11%) Frame = +3 Query: 264 DIY YTNVSRQTGNTSMPA-------YEASLGRATSTNYPLVNFLLSADADFVIG ... ALGS-- 416 DIY + R+ GN A Y + T Y L N+ +ADA+ VI A+GS Sbjct: 223 DIY ... itives = 23/46 (50%) Frame = +3 Query: 240 SKAYSRWWDIY YTNVSRQTGNTSMPAYEASLGRATSTNYPLVNFLL 377 S SRW + N T ... HYSVLYFSEGYISDIRGNTF 219 Query: 219 MQEVIEESKAYSRWWDIY YTNVSRQTGNTSMPAYEASLGRATSTNYPLVNFLLSADADFV 398 + +V ...

  2. Variables sociodemográficas y estilos de vida como predictores de la autovaloración de la salud de los inmigrantes en el País Vasco Sociodemographic variables and lifestyle as predictors of self-perceived health in immigrants in the Basque Country (Spain)

    OpenAIRE

    Elena Rodríguez Álvarez; Nerea Lanborena Elordui; Meftaha Senhaji; Celina Pereda Riguera

    2008-01-01

    Objetivo: Investigar la importancia de los factores sociodemográficos y de los estilos de vida en la autovaloración de la salud en los inmigrantes de origen magrebí, subsahariano, latinoamericano y europeo no comunitario del País Vasco. Métodos: Estudio descriptivo transversal con una muestra formada por 219 magrebíes (31,8%), 152 subsaharianos (22,1%), 167 latinoamericanos (24,2%) y 151 europeos no comunitarios (21,9%). La herramienta para la recopilación de datos fue la Encuesta de Salud de...

  3. Self-Limited versus Delayed Resolution of Acute Inflammation: Temporal Regulation of Pro-Resolving Mediators and MicroRNA

    OpenAIRE

    Gabrielle Fredman; Yongsheng Li; Jesmond Dalli; Nan Chiang; Serhan, Charles N.

    2012-01-01

    Mechanisms underlying delays in resolution programs of inflammation are of interest for many diseases. Here, we addressed delayed resolution of inflammation and identified specific microRNA (miR)-metabolipidomic signatures. Delayed resolution initiated by high-dose challenges decreased miR-219-5p expression along with increased leukotriene B4 (5-fold) and decreased (~3-fold) specialized pro-resolving mediators, e.g. protectin D1. Resolvin (Rv)E1 and RvD1 (1 nM) reduced miR-219-5p in human mac...

  4. AcEST: DK961289 [AcEST

    Lifescience Database Archive (English)

    Full Text Available TST39A01NGRL0009_L10 572 Adiantum capillus-veneris mRNA. clone: TST39A01NGRL0009_L10. 5' end seq ... LQDCQK--LTDLS 219 Query: 356 CKKL-KGLVNLRILNLAY-NDVTDA GMAYLKGLTNLEELNLDSC-KVGDAGL 502 K + +GL LR+LNL++ ++ ... SLSLCSCHISDDG 321 Query: 356 CKKL-KGLVNLRILNLAY-NDVTDA GMAYL-KGLTNLEELNLDSC-KVGDAGLE 505 ++ + + LR LN+ +TD ... 4/44 (9%) Frame = +2 Query: 365 LKGLVNLRILNLA--YNDVTDA GM--AYLKGLTNLEELNLDSCK 484 ++G+ N+ LNL+ YN +TD G+ A ... LQDCQK--LTDLS 219 Query: 356 CKKL-KGLVNLRILNLAY-NDVTDA GMAYLKGLTNLEELNLDSC-KVGDAGL 502 K + +GL LR+LNL++ ++ ...

  5. AcEST: DK947792 [AcEST

    Lifescience Database Archive (English)

    Full Text Available YMU02A01NGRM0001_A07 490 Adiantum capillus-veneris mRNA. clone: YMU02A01NGRM0001_A07. 5' end seq ... uery: 198 XXXXXXXXXXXRMKSGGNIVDYHGCEFFPERWFDLVVVLQTDNS ILYDRLMNR 356 M GGN+VD+HGCE+FPERWFDLV+VL+TD IL DRL ... VD 63 Query: 219 XXXXRMKSGGNIVDYHGCEFFPERWFDLVVVLQTDNS ILYDRLMNR 356 +M GG IVDYHGC+FFPERWF +V VL+TDNS ILY R ... L NR Sbjct: 64 ELENQMSEGGVIVDYHGCDFFPERWFHIVFVLKTDNS ILYKRLENR 109 >sp|Q5EB68|KAD6_RAT Adenylate kinase ... VD 63 Query: 219 XXXXRMKSGGNIVDYHGCEFFPERWFDLVVVLQTDNS ILYDRLMNR 356 +M GG IVDYHGC+FFPERWF +V VL+TDN ILY R ...

  6. Několik poznámek k problematice ochrany duševního vlastnictví

    Czech Academy of Sciences Publication Activity Database

    Krejčí, Jindřich

    2011-01-01

    Roč. 5, č. 2 (2011), s. 217-219. ISSN 1802-8152 R&D Projects: GA MŠk LM2010006 Institutional research plan: CEZ:AV0Z70280505 Keywords : social science databases * intellectual property rights * open access Subject RIV: AO - Sociology, Demography http://dav.soc.cas.cz/uploads/9aded5ef84867217588bfc788d640e8a3b0e50d2_DaVp217-219%20Krejci.pdf

  7. The local heat treatment technology for not easily accessible welded joints of sodium-conducting pipes in nuclear power stations

    International Nuclear Information System (INIS)

    Experimental works results in local heat treatment of not easily accessible welded joints for the nuclear power stations sodium-conducting pipes using flexible wired resistance heaters are described. Vertical welded joints 820x13, 630x13, 219x10 and 245x11 were studied. It was found out that for the tubes welded joints 219x10 and 245x11mm the normal process of austenization without reflectors inside the welded joint is achieved under heating by means of one electric heater. It was suggested that the electric heater capacity should be increased for tubes welded joints 820x13 and 630x13 mm

  8. Unfolding transitions in myosin give rise to the double-hyperbolic force-velocity relation in muscle

    DEFF Research Database (Denmark)

    Nielsen, Bjørn Gilbert

    2003-01-01

    This work presents an extension to a recent model of muscle contraction that was based on entropic elasticity (Nielsen 2002 J. Theor Biol. 219 99-119). By using entropic elasticity as the origin of muscle force, various possibilities emerge that can account for the presence of the double-hyperbol......This work presents an extension to a recent model of muscle contraction that was based on entropic elasticity (Nielsen 2002 J. Theor Biol. 219 99-119). By using entropic elasticity as the origin of muscle force, various possibilities emerge that can account for the presence of the double...

  9. UREDNIČKI OPOZIV RADA: Fleksibilni Fourierov stacionarni test BDP-a po stanovniku za Srednjoistočne europske zemlje

    OpenAIRE

    Chang, Hsu-Ling; Su, Chi-Wei; Zhu, Meng-Nan

    2011-01-01

    Statement of Retraction (Zb. rad. Ekon. fak. Rij. • 2012 • vol. 30 • sv. 2 • 219-219, http://www.efri.uniri.hr/dokumenti/zbornik-2012-2-retraction.pdf): Želimo obavijestiti poštovane čitatelje da je Urednički odbor časopisa Zbornik radova Ekonomskog fakulteta u Rijeci, časopis za ekonomsku teoriju i praksu/ Proceedings of Rijeka Faculty of Economics, Journal of Economics and Business povukao sljedeći članak iz publikacije: “Flexible Fourier Stationary Test in GDP per capita for Cent...

  10. Monolithic Hybrid and Passive Mode-Locked 40GHz Quantum Dot Laser Diodes

    DEFF Research Database (Denmark)

    Thompson, M. G.; Larsson, David; Rae, A. R.;

    2006-01-01

    For the first time hybrid and passive mode-locking jitter performance is investigated in 40GHz quantum-dot mode-locked lasers. Record low passive mode-locking jitter of 219fs is presented, along with promising hybrid mode-locking results of 124fs.......For the first time hybrid and passive mode-locking jitter performance is investigated in 40GHz quantum-dot mode-locked lasers. Record low passive mode-locking jitter of 219fs is presented, along with promising hybrid mode-locking results of 124fs....

  11. Resposta de plantas micropropagadas de abacaxizeiro à inoculação de bactérias diazotróficas em casa de vegetação Response of pineapple plantlets to inoculation with diazotrophic bacteria in greenhouse

    Directory of Open Access Journals (Sweden)

    Olmar Baller Weber

    2003-12-01

    Full Text Available O objetivo deste trabalho foi selecionar e avaliar bactérias diazotróficas isoladas de abacaxizeiro (Ananas comosus (L. Merril no desenvolvimento de cultivares micropropagadas da mesma espécie em casa de vegetação. Plantas da cultivar Perolera foram submetidas à inoculação com Asaia bogorensis (AB219 e cultivadas em tubetes, durante 145 dias, com as misturas: casca de arroz carbonizada, folha de carnaubeira triturada e vermicomposto; casca de arroz carbonizada, pó da casca do coco maduro e vermicomposto; casca de arroz carbonizada, vermiculita e vermicomposto. Plantas da cultivar Primavera receberam inóculos com o AB219 e bactérias relacionadas a Burkholderia cepacia (AB202 e AB213, enquanto plantas das cultivares Pérola e Smooth Cayenne receberam AB219 e AB213, sendo cultivadas, por 140 dias, em tubetes com a mistura de vermicomposto e vermiculita. A colonização dos abacaxizeiros pelas bactérias diazotróficas foi confirmada. As plantas da cultivar Perolera cresceram melhor em casca de arroz carbonizada, vermiculita e vermicomposto e responderam positivamente ao AB219. Já as plantas da cultivar Primavera não apresentaram resposta significativa à inoculação com AB219, AB202 e AB213. Houve incremento de 23,1% a 38,5% na matéria seca de raízes das plantas da cultivar Pérola na presença de AB213 e AB219, respectivamente. A presença de AB213 incrementou em 15,2% a matéria seca da parte aérea das plantas da cultivar Smooth Cayenne. Os resultados revelam a eficiência de bactérias diazotróficas na promoção do crescimento de abacaxizeiros.The objective of this work was to select and to evaluate isolates of diazotrophic bacteria associated to pineapple (Ananas comosus (L. Merril plants in the development of micropropagated plantlets of cultivars pineapple in greenhouse. Plantlets from the Perolera cultivar have been submitted to inoculation with Asaia bogorensis (AB219 and were cultivated during 145 days on the following

  12. The biokinetics of alpha-particle emitting radiopharmaceuticals

    International Nuclear Information System (INIS)

    The past two decades have seen wide interest in the application of alpha-particle emitting radionuclides for targeted endoradiotherapy and a large number of compounds labeled with 211At (T1/2 7.21 h), 212Bi (T1/2 1 h) or 213Bi (T1/2 0.78 h) have been studied. Knowledge of the biokinetic behaviour of such agents is important both for their optimal clinical exploitation and for general radiological protection purposes. Animal studies of the distribution and retention of 211At compounds, including ionic astatide, substituted aromatic compounds and labelled monoclonal antibodies, have provided new information on the biochemistry of astatine. With respect the thyroid gland the uptake of the astatide ion has been shown to be very much lower than that of the iodide ion. Less information is available for 212Bi-labelled radiopharmaceuticals. The available data for both 211At and 212Bi radiopharmaceuticals are reviewed. Cautious generic biokinetic models for inorganic and simple organic compounds of 211At and 212Bi; for [211At]-, and [212Bi]-biphosphonates and for [211At]-, and [212Bi]-monoclonal antibodies, are proposed for use in general radiological protection when compound-specific data are not available. (orig.)

  13. The radiolabeled monoclonal antibodies in immunoscintigraphy and radioimmunotherapy: current state and perspectives

    International Nuclear Information System (INIS)

    The antibodies can be satisfactorily labelled with technitium-99 m or indium-111 for tumor immunoscintigraphy. The immunoscintigraphy is not useful for the primary tumor diagnosis. It can be useful for the diagnosis of the some cancer extension and for recurrent tumor visualization. The immunoscintigraphy is widely competed with Positron Emission Tomography (PET) which gives accurate results. In the future the immunoscintigraphy, in pre-therapeutic stage, contribute to the estimation of the dose delivered to the tumor and to normal organs for adopting or not a radioimmunotherapy. The antibodies can also be labeled with Iodine-131 for an application in radioimmunotherapy (RIT). The RIT is efficient in the non-Hodgkin's lymphoma treatment because of their great radiosensitivity. Until now the results have been very modest in solid tumor treatment but methodological and biotechnological progresses have to improve the efficiency especially for the small tumors. In the future iodine-131 which requires the confinement (very expensive) of patients will be substituted by yttrium-90 beta emitter, more energetic than iodine-131 and can be injected in walking case. In the long term, the alpha emitter radionuclides (astatine-211 or bismuth-213) can be used for hematologic cancer treatment. In conclusion the future of radiolabeled monoclonal antibodies is essentially therapeutic. The radioimmunotherapy associated to the chemotherapy give promising perspectives for the radiosensitive cancer treatment and in general small solid tumor treatment (F.M.)

  14. Biological toxicity of intracellular radionuclide decay. Part of a coordinated programme on radiation biology of Auger emitters and their therapeutic applications

    International Nuclear Information System (INIS)

    Internal radiotherapy should be performed with short-lived radionuclides which emit high LET radiation and short ranged radiation, and accumulated within cancers. Based on these considerations, several radionuclides (tritium, copper-64, gallium-67, iodine-123, iodine 125, iodine-131 and astatine-211) were chosen and their toxicity was assessed using cell division in mammalian cultured cells as a criterion. It was apparent that the toxic effects obtained with 125I greatly exceeded those observed in cells treated with any other radionuclides. The possible hypotheses to explain the excessive radiosensitivity of 125I were discussed in relation to microdosimetry calculation. It was also found that the division delay induced by radionuclide decay is primarily due to damage to the cell nucleus but not to the plasma membrane. The key problem remains the development of agents which can serve as carriers for radionuclide accumulation within tumors. Although several promising approaches (Synkavit, tamoxifen, iododeoxyuridine, antibodies, liposomes) were investigated, only 125I-labelled Synkavit would be desirable for clinical application

  15. Study of Neutron-Deficient $^{202-205}$Fr Isotopes with Collinear Resonance Ionization Spectroscopy

    CERN Document Server

    De Schepper, Stijn; Cocolios, Thomas; Budincevic, Ivan

    The scope of this master’s thesis is the study of neutron-deficient $^{202−205}$Fr isotopes. These isotopes are inside the neutron-deficient lead region, a region that has shown evidence of shape coexistence. For this thesis, this discussion is limited to the phenomenon where a low lying excited state has a different shape than the ground state. Shape coexistence is caused by intruder states. These are single-particle Shell Model states that are perturbed in energy due to the interaction with a deformed core. In the neutron-deficient lead region the main proton intruder orbit is the 3s$_{1/2}$orbit. When going towards more neutron-deficient isotopes, deformation increases. The $\\pi3s_{1/2}$orbit will rise in energy and will eventually become the ground state in odd- A bismuth (Z=83) isotopes. It is also observed in odd-A astatine (Z=85) isotopes, already in less neutron-deficient nuclei. The same phenomenon is expected to be present francium (Z=87) isotopes already at $^{199}$Fr. Although it is currently ...

  16. The biokinetics of alpha-particle emitting radiopharmaceuticals

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, D.M. [School of Chemistry, Cardiff Univ., Cardiff (United Kingdom); Duffield, J.R. [Faculty of Applied Sciences, Univ. of the West of England, Bristol (United Kingdom)

    2005-07-01

    The past two decades have seen wide interest in the application of alpha-particle emitting radionuclides for targeted endoradiotherapy and a large number of compounds labeled with {sup 211}At (T{sup 1}/{sub 2} 7.21 h), {sup 212}Bi (T{sup 1}/{sub 2} 1 h) or {sup 213}Bi (T{sup 1}/{sub 2} 0.78 h) have been studied. Knowledge of the biokinetic behaviour of such agents is important both for their optimal clinical exploitation and for general radiological protection purposes. Animal studies of the distribution and retention of {sup 211}At compounds, including ionic astatide, substituted aromatic compounds and labelled monoclonal antibodies, have provided new information on the biochemistry of astatine. With respect the thyroid gland the uptake of the astatide ion has been shown to be very much lower than that of the iodide ion. Less information is available for {sup 212}Bi-labelled radiopharmaceuticals. The available data for both {sup 211}At and {sup 212}Bi radiopharmaceuticals are reviewed. Cautious generic biokinetic models for inorganic and simple organic compounds of {sup 211}At and {sup 212}Bi; for [{sup 211}At]-, and [{sup 212}Bi]-biphosphonates and for [{sup 211}At]-, and [{sup 212}Bi]-monoclonal antibodies, are proposed for use in general radiological protection when compound-specific data are not available. (orig.)

  17. Effect of cetuximab in combination with alpha-radioimmunotherapy in cultured squamous cell carcinomas

    International Nuclear Information System (INIS)

    Aim: The monoclonal antibody cetuximab, targeting the epidermal growth factor receptor (EGFR), is a promising molecular targeting agent to be used in combination with radiation for anticancer therapy. In this study, effects of cetuximab in combination with alpha-emitting radioimmunotherapy (RIT) in a panel of cultured human squamous cell carcinomas (SCCs) were assessed. Methods: SCC cell lines were characterized and treated with cetuximab in combination with anti-CD44v6 RIT using the astatinated chimeric monoclonal antibody U36 (211At-cMAb U36). Effects on 211At-cMAb U36 uptake, internalization and cell proliferation were then assessed in SCC cells. Results: Cetuximab in combination with 211At-cMAb U36 mediated increased growth inhibition compared to RIT or cetuximab alone in two cell lines. However, cetuximab also mediated radioprotective effects compared to RIT alone in two cell lines. The radioprotective effects occurred in the cell lines in which cetuximab clearly inhibited cell growth during radiation exposure. Cetuximab treatment also influenced 211At-cMAb-U36 uptake and internalization, suggesting interactions between CD44v6 and EGFR. Conclusions: Results from this study demonstrate the vast importance of further clarifying the mechanisms of cetuximab and radiation response, and the relationship between EGFR and suitable RIT targets. This is important not only in order to avoid potential radioprotective effects, but also in order to find and utilize potential synergistic effects from these combinations.

  18. Tumor immunotargeting using innovative radionuclides.

    Science.gov (United States)

    Kraeber-Bodéré, Françoise; Rousseau, Caroline; Bodet-Milin, Caroline; Mathieu, Cédric; Guérard, François; Frampas, Eric; Carlier, Thomas; Chouin, Nicolas; Haddad, Ferid; Chatal, Jean-François; Faivre-Chauvet, Alain; Chérel, Michel; Barbet, Jacques

    2015-01-01

    This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality. PMID:25679452

  19. Tumor Immunotargeting Using Innovative Radionuclides

    Directory of Open Access Journals (Sweden)

    Françoise Kraeber-Bodéré

    2015-02-01

    Full Text Available This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality.

  20. Proceedings of transuranium elements

    International Nuclear Information System (INIS)

    The identification of the first synthetic elements was established by chemical evidence. Conclusive proof of the synthesis of the first artificial element, technetium, was published in 1937 by Perrier and Segre. An essential aspect of their achievement was the prediction of the chemical properties of element 43, which had been missing from the periodic table and which was expected to have properties similar to those of manganese and rhenium. The discovery of other artificial elements, astatine and francium, was facilitated in 1939-1940 by the prediction of their chemical properties. A little more than 50 years ago, in the spring of 1940, Edwin McMillan and Philip Abelson synthesized element 93, neptunium, and confirmed its uniqueness by chemical means. On August 30, 1940, Glenn Seaborg, Arthur Wahl, and the late Joseph Kennedy began their neutron irradiations of uranium nitrate hexahydrate. A few months later they synthesized element 94, later named plutonium, by observing the alpha particles emitted from uranium oxide targets that had been bombarded with deuterons. Shortly thereafter they proved that is was the second transuranium element by establishing its unique oxidation-reduction behavior. The symposium honored the scientists and engineers whose vision and dedication led to the discovery of the transuranium elements and to the understanding of the influence of 5f electrons on their electronic structure and bonding. This volume represents a record of papers presented at the symposium

  1. Silver impregnated nanoparticles of titanium dioxide as carriers for {sup 211}At

    Energy Technology Data Exchange (ETDEWEB)

    Cedrowska, Edyta; Lyczko, Monika; Piotrowska, Agata; Bilewicz, Aleksander [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); Stolarz, Anna; Trcinska, Agnieszka [Warsaw Univ. (Poland). Heavy Ion Lab.; Szkliniarz, Katarzyna [Silesia Univ. Katowice (Poland). Inst. of Physics; Was, Bogdan [Polish Academy of Science, Cracow (Poland). Inst. of Nuclear Physics

    2016-08-01

    The {sup 211}At radioisotope exhibits very attractive nuclear properties for application in radionuclide therapy. Unfortunately use of {sup 211}At is limited, because astatine as the heaviest halogen forms weak bond with carbon atoms in the biomolecules which makes {sup 211}At bioconjugates unstable in physiological conditions. In our work we propose a new solution for binding of {sup 211}At which consists of using nanoparticles of titanium dioxide modified with silver atoms as carriers for {sup 211}At. Ag{sup +} cations have been absorbed on the nanometer-sized TiO{sub 2} particles (15 and 32 nm) through ion exchange process and were reduced in Tollens' reaction. The obtained TiO{sub 2}-Ag nanoparticles were labeled with {sup 211}At. It was found that labeling yields were almost quantitative under reducing conditions, while under oxidizing conditions they dropped to about 80%. The labeled nanoparticles exhibited very high stability in physiological salt, PBS buffer, solutions of peptides (0.001 M cysteine, 0.001 M glutathione) and in human blood serum. To make TiO{sub 2}/Ag nanoparticles well dispersed in water and biocompatible their surface was modified with a silane coupling agent containing poly(ethyleneglycol) molecules. The developed functionalization approach will allow us to attach biomolecules to the TiO{sub 2}/Ag surface.

  2. Development and radiotherapeutic application of 211At-labeled radiopharmaceuticals. Progress report, March 1, 1981-February 28, 1982

    International Nuclear Information System (INIS)

    This project is concerned with developing the potential of alpha-emitting radionuclides as agents for radiotherapy. Alpha-emitters seem ideally suited for his application because their high linear energy transfer and short range permit the deposition of considerable energy in a very small volume of tissue. Unlike the beta particles of 131I which have a range of about 1 to 2 mm in tissue, 5 to 7 MeV alpha particles would traverse only a few cell diameters. Among the available alpha-emitters, 211At appears most promising for therapeutic applications because, (1) it has some chemical similarities to iodine, an element that can readily be incorporated into numerous proteins and peptides, (2) it has a half-life that is long enough to permit chemical manipulation yet short enough to minimize destruction of healthy cells due to degradation of the label over time, (3) it can be produced conveniently using a cyclotron, and (4) alpha emission is associated with 100% of its decays with no accompanying beta emission. In the past year the evaluation of an astatine-tellurium colloid as an agent for the destruction of malignant ascites has been completed. The therapeutic efficacy of 211At-tellurium colloid has been compared with that of several beta-emitting radiocolloids. Studies on the application of monoclonal antibodies as carriers for selective delineation and destruction of malignant cell populations have also been initiated

  3. Nuclear and chemical data for life sciences

    International Nuclear Information System (INIS)

    Use of reactor produced radionuclides is popular in life sciences. However, cyclotron production of proton rich radionuclides are being more focused in recent times. These radionuclides have already gained attention in various fields, including life sciences, provided they are obtained in pure form. This article is a representative brief of our contributions in generating nuclear data for the production of proton rich radionuclides of terbium, astatine, technetium, ruthenium, cadmium, niobium, zirconium, rhenium, etc., which may have application in clinical, biological, agriculture studies or in basic research. The chemical data required to separate the product isotopes from the corresponding target matrix have been presented along with a few propositions of radiopharmaceuticals. It also emphasizes on the development of simple empirical technique, based on the nuclear reaction model analysis, to generate reliable nuclear data for the estimation of yield and angular distribution of emitted neutrons and light charged particles from light as well as heavy ion induced reactions on thick stopping targets. These data bear utmost important in radiation dosimetry. (author)

  4. Studies of Stable Octupole Deformations in the Radium Region

    CERN Multimedia

    2002-01-01

    The purpose of the present project is to locate and identify states in the atomic nuclei possessing stable pearshaped octupole deformation. Such states, formally related to the structures known in molecular physics, manifest themselves as families of parity doublets in odd nuclei.\\\\ \\\\ The best possibilities for observing stable octupole deformations are offered in the Ra-region. Both theoretical calculations and experimental indications support such expectations. Such indications are the non-observation of two-phonon octupole vibrational states in the ISOLDE studies of the even-even radium nuclei, and the reversed sign of the decoupling factor of the ground state band in |2|2|5Ra observed in the single-neutron transfer reactions. In order to establish the predicted strong E1 and E3-transitions between the parity doublets in odd nuclei with stable octupole deformations it is proposed to study conversion electrons in odd-mass francium radium and radon isotopes following the @b-decay of francium and astatine. \\...

  5. Effect of cetuximab in combination with alpha-radioimmunotherapy in cultured squamous cell carcinomas

    Energy Technology Data Exchange (ETDEWEB)

    Nestor, Marika, E-mail: marika.nestor@bms.uu.s [Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, S-751 85 Uppsala (Sweden); Unit of Biomedical Radiation Sciences, Department of Oncology, Radiology and Clinical Immunology, Uppsala University, S-751 85 Uppsala (Sweden); Sundstroem, Magnus [Unit of Molecular Pathology, Department of Genetics and Pathology, Uppsala University (Sweden); Anniko, Matti [Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, S-751 85 Uppsala (Sweden); Tolmachev, Vladimir [Unit of Biomedical Radiation Sciences, Department of Oncology, Radiology and Clinical Immunology, Uppsala University, S-751 85 Uppsala (Sweden)

    2011-01-15

    Aim: The monoclonal antibody cetuximab, targeting the epidermal growth factor receptor (EGFR), is a promising molecular targeting agent to be used in combination with radiation for anticancer therapy. In this study, effects of cetuximab in combination with alpha-emitting radioimmunotherapy (RIT) in a panel of cultured human squamous cell carcinomas (SCCs) were assessed. Methods: SCC cell lines were characterized and treated with cetuximab in combination with anti-CD44v6 RIT using the astatinated chimeric monoclonal antibody U36 ({sup 211}At-cMAb U36). Effects on {sup 211}At-cMAb U36 uptake, internalization and cell proliferation were then assessed in SCC cells. Results: Cetuximab in combination with {sup 211}At-cMAb U36 mediated increased growth inhibition compared to RIT or cetuximab alone in two cell lines. However, cetuximab also mediated radioprotective effects compared to RIT alone in two cell lines. The radioprotective effects occurred in the cell lines in which cetuximab clearly inhibited cell growth during radiation exposure. Cetuximab treatment also influenced {sup 211}At-cMAb-U36 uptake and internalization, suggesting interactions between CD44v6 and EGFR. Conclusions: Results from this study demonstrate the vast importance of further clarifying the mechanisms of cetuximab and radiation response, and the relationship between EGFR and suitable RIT targets. This is important not only in order to avoid potential radioprotective effects, but also in order to find and utilize potential synergistic effects from these combinations.

  6. Alpha particle emitters in medicine

    International Nuclear Information System (INIS)

    Radiation-induced cancer of bone, liver and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High dose rates at high LET, effectiveness under hypoxic conditions, and minimal expectancy of repair are additional advantages of alpha emitters over antibodies labeled with beta emitting radionuclides for cancer therapy. Cyclotron-produced astatine-211 (211At) and natural bismuth-212 (212Bi) have been proposed and are under extensive study in the United States and Europe. Radium-223 (223Ra) also has favorable properties as a potential alpha emitting label, including a short-lived daughter chain with four alpha emissions. The radiation dosimetry of internal alpha emitters is complex due to nonuniformly distributed sources, short particle tracks, and high relative specific ionization. The variations in dose at the cellular level may be extreme. Alpha-particle radiation dosimetry, therefore, must involve analysis of statistical energy deposition probabilities for cellular level targets. It must also account fully for nonuniform distributions of sources in tissues, source-target geometries, and particle-track physics. 18 refs., 4 figs

  7. Preparation of 211At-labeled humanized anti-Tac using 211At produced in disposable internal and external bismuth targets

    International Nuclear Information System (INIS)

    These studies describe the production and purification of 211At as well as the procedure for labeling humanized anti-Tac, the antibody to the α-chain of the IL-2 receptor (IL-2Rα), which has been shown to be a useful target for immunotherapy. The optimized protocol combines the advantages of the two-stage dry distillation procedure with the astatination of trialkylstannyl substances as labeling compounds for proteins. The 211At was produced by bombarding either an external or a recently developed disposable internal bismuth target with α-particles from a Cyclotron Corporation CS-30 cyclotron. The 211At was found to contain less than 0.01% 210At. The production rate for the external target was 0.15 mCi ± 0.056 μA-1 h-1 (n = 9) (5.55 MBq μA-1 h-1). The production rate for the internal target was 0.44 ± 0.14 mCi μA-1 h-1 (n = 16) (16.28 MBq μA-1 h-1)

  8. Kategorie výzdobného stylu na lineární keramice z Bylan

    Czech Academy of Sciences Publication Activity Database

    Květina, Petr; Končelová, Markéta

    2011-01-01

    Roč. 63, č. 2 (2011), s. 195-219. ISSN 0323-1267 R&D Projects: GA ČR(CZ) GAP405/11/1590 Institutional research plan: CEZ:AV0Z80020508 Keywords : Early Neolithic * style of pottery decoration * Bylany Subject RIV: AC - Archeology, Anthropology, Ethnology

  9. 2D hydrodynamic simulations of super star cluster winds in a bimodal regime

    Czech Academy of Sciences Publication Activity Database

    Wünsch, Richard; Palouš, Jan; Tenorio-Tagle, G.; Silich, S.

    2009-01-01

    Roč. 324, 2-4 (2009), s. 219-223. ISSN 0004-640X R&D Projects: GA MŠk(CZ) LC06014 Institutional research plan: CEZ:AV0Z10030501 Keywords : stellar wind s * star cluster s * dynamics of ISM Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 1.404, year: 2009

  10. A simulation analysis of an extension of one-dimensional speckle correlation method for detection of general in-plane translation

    Czech Academy of Sciences Publication Activity Database

    Hamarová, Ivana; Šmíd, Petr; Horváth, P.; Hrabovský, M.

    2014-01-01

    Roč. 2014, č. 1 (2014), "704368-1"-"704368-12". ISSN 1537-744X R&D Projects: GA ČR GA13-12301S Institutional support: RVO:68378271 Keywords : one -dimensional speckle correlation * speckle * general In-plane translation Subject RIV: BH - Optics, Masers, Lasers Impact factor: 1.219, year: 2013

  11. Biodegradation of spilled diesel fuel in agricultural soil: Effect of humates, zeolite, and bioaugmentation

    Czech Academy of Sciences Publication Activity Database

    Kuráň, P.; Trögl, J.; Nováková, J.; Pilařová, V.; Dáňová, P.; Pavlorková, J.; Kozler, J.; Novák, František; Popelka, J.

    -, č. 642427 (2014). ISSN 1537-744X Grant ostatní: GA MPO(CZ) FR-TI1/456 Institutional support: RVO:60077344 Keywords : biodegradation * spilled diesel fuel * agricultural soil Subject RIV: DK - Soil Contamination ; De-contamination incl. Pesticides Impact factor: 1.219, year: 2013 http://dx.doi.org/10.1155/2014/642427

  12. Single crystalline film scintillators based on the orthosilicate, perovskite and garnet compounds

    Czech Academy of Sciences Publication Activity Database

    Zorenko, Y.; Gorbenko, V.; Savchyn, V.; Voznyak, T.; Sidletskiy, O.; Grinyov, B.; Nikl, Martin; Mareš, Jiří A.; Martin, T.; Douissard, P.-A.

    2012-01-01

    Roč. 59, č. 5 (2012), s. 2260-2268. ISSN 0018-9499 R&D Projects: GA ČR GA202/08/0893 Institutional research plan: CEZ:AV0Z10100521 Keywords : Ce 3+ , Tb 3+ and Sc 3+ dopants * garnets Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.219, year: 2012

  13. Inventory of rodent damage to forests

    Czech Academy of Sciences Publication Activity Database

    Kamler, Jiří; Turek, K.; Homolka, Miloslav; Baňař, P.; Barančeková, Miroslava; Heroldová, Marta; Krojerová, Jarmila; Suchomel, J.; Purchart, L.

    2011-01-01

    Roč. 57, č. 5 (2011), s. 219-225. ISSN 1212-4834 R&D Projects: GA MZe QH72075 Institutional research plan: CEZ:AV0Z60930519 Keywords : bank vole * field vole * bark damage * forest protection Subject RIV: GK - Forestry http://www.agriculturejournals.cz/publicFiles/40074.pdf

  14. The lamellar spacing in self-assembling bacteriochlorophyll aggregates is proportional to the length of the esterifying alcohol

    Czech Academy of Sciences Publication Activity Database

    Pšenčík, J.; Torkkeli, M.; Župčanová, Anita; Vácha, František; Serimaa, R.E.; Tůma, R.

    2010-01-01

    Roč. 104, 2-3 (2010), s. 211-219. ISSN 0166-8595 R&D Projects: GA ČR GA206/09/0375 Institutional research plan: CEZ:AV0Z50510513 Keywords : Green photosynthetic bacteria * Chlorosome * Bacteriochlorophyll Subject RIV: CE - Biochemistry Impact factor: 2.410, year: 2010

  15. Comparative analysis of genome-wide divergence, domestication footprints and genome-wide association study of root traits for Gossypium hirsutum and Gossypium barbadense

    Science.gov (United States)

    Use of 10,129 singleton SNPs of known genomic location in tetraploid cotton provided unique opportunities to characterize genome-wide diversity among 440 Gossypium hirsutum and 219 G. barbadense cultivars and landrace accessions of widespread origin. Using genome-wide distributed SNPs, we examined ...

  16. N,3,4-Trisubstituted pyrrolidines by electron transfer-induced oxidative cyclizations of N-allylic beta-amino ester enolates

    Czech Academy of Sciences Publication Activity Database

    Jahn, Ullrich; Kafka, František; Pohl, Radek; Jones, P.G.

    2009-01-01

    Roč. 65, č. 52 (2009), s. 10917-10929. ISSN 0040-4020 Institutional research plan: CEZ:AV0Z40550506 Keywords : electron transfer * pyrrolidines * oxidation Subject RIV: CC - Organic Chemistry Impact factor: 3.219, year: 2009

  17. 36 CFR 223.279 - Personal use.

    Science.gov (United States)

    2010-07-01

    .... In conjunction with determining sustainable harvest levels under § 223.219, the responsible Forest... 223.279 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER Forest Botanical Products § 223.279 Personal use. (a)...

  18. Malakostratigrafie vchodového valu Medvědí jeskyně ve Slovenském ráji

    Czech Academy of Sciences Publication Activity Database

    Ložek, Vojen

    2012-01-01

    Roč. 2011, podzim (2012), s. 219-222. ISSN 0514-8057 Institutional research plan: CEZ:AV0Z30130516 Keywords : Slovenský raj * Medvedia Cave * entrance rampart * Holocene * Mollusca * foam sinter Subject RIV: DB - Geology ; Mineralogy http://www.geology.cz/zpravy/obsah/2011/zpravy_2011-49.pdf

  19. 75 FR 28606 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

    Science.gov (United States)

    2010-05-21

    ... July 30, 2009 (74 FR 38005), EPA sought comments on this ICR pursuant to 5 CFR 1320.8(d). EPA received... information is estimated to average 219 hours per response. Burden means the total time, effort, or financial..., due to a math error in the previous ICR. Also, there is an increase in both respondent and...

  20. Escherichia coli rpiA gene encoding ribose phosphate isomerase A

    DEFF Research Database (Denmark)

    Hove-Jensen, Bjarne; Maigaard, Marianne

    1993-01-01

    was sequenced and shown to harbor an open reading frame of 219 codons, sufficient to encode a polypeptide with an Mr of 22,845. The synthesis of the rpiA-encoded polypeptide was detected by analysis of minicells, which established the subunit Mr as 27,000. The assignment of the correct reading frame...

  1. Complexation of Eu3+ with a macrocyclic lactam receptor: Experimental and theoretical study

    Czech Academy of Sciences Publication Activity Database

    Makrlík, E.; Záliš, Stanislav; Sedláková, Zdeňka; Vaňura, P.

    2013-01-01

    Roč. 1038, APR 2013 (2013), s. 216-219. ISSN 0022-2860 Institutional support: RVO:61388955 ; RVO:61389013 Keywords : europium * macrocyclic lactam receptor * complexation Subject RIV: CF - Physical ; Theoretical Chemistry; CD - Macromolecular Chemistry (UMCH-V) Impact factor: 1.599, year: 2013

  2. [Christofer Herrmann. Kloster und Burg - die architektur des Deutschens Ordens im Pressen und Livland. In : Glaube, Macht und Pracht. GeistlicheGemeinschaften des Ostseeraums im Zeitalter der Backsteingotik] / Dennis Hortmuth

    Index Scriptorium Estoniae

    Hortmuth, Dennis

    2011-01-01

    Arvustus: Christofer Herrmann. Kloster und Burg - die Architektur des Deutschen Ordens in Preussen und Livland. In : Glaube, Macht und Pracht. GeistlicheGemeinschaften des Ostseeraums im Zeitalter der Backsteingotik (=Archäologie und Geschichte im Ostseeraum; Archaeology and History of the Baltic 6) Rahden : Verlag Marie Leidorf, 2009. S. 209-219. Saksa Ordu arhitektuurist Preisi- ja Liivimaal

  3. Facing Guilt: Role of Negative Affectivity, Need for Reparation, and Fear of Punishment in Leading to Prosocial Behaviour and Aggression

    Czech Academy of Sciences Publication Activity Database

    Caprara, G. V.; Barbaranelli, C.; Pastorelli, C.; Čermák, Ivo; Rozsa, S.

    2001-01-01

    Roč. 15, č. 3 (2001), s. 219-237. ISSN 0890-2070 Institutional research plan: CEZ:AV0Z7025918 Keywords : emotional predictors of aggression * Guilt * Negative Affectivity Subject RIV: AN - Psychology Impact factor: 1.081, year: 2001

  4. Molecular evidence for extra-pair paternity and intraspecific blood parasitism in the black-headed gull

    Czech Academy of Sciences Publication Activity Database

    Ležalová-Piálková, Radka

    Perth: International Society for Behavioral Ecology, 2010. s. 219. [Congress of the International Society for Behavioral Ecology /13./. 26.09.2010-01.10.2010, Perth] Institutional research plan: CEZ:AV0Z60930519 Keywords : black headed gull Subject RIV: EG - Zoology http://www.isbeperth2010.com/docs/ISBE%202010%20Abstract%20Book%20Final.pdf

  5. Sochařství z Mnichova v Čechách a čeští sochaří v Mnichově / Die Bildhauerkunst aus München in Böhmen und tschechische Bildhauer in München

    Czech Academy of Sciences Publication Activity Database

    Petrasová, Taťána

    Praha: Academia, 2012 - (Petrasová, T.; Prahl, R.), s. 219-256 ISBN 978-80-200-1889-2 R&D Projects: GA AV ČR IAA800330602 Institutional research plan: CEZ:AV0Z80330511 Keywords : Czech sculpture * 19th century * artistic schools Subject RIV: AL - Art, Architecture, Cultural Heritage

  6. Oratorium v Czechach, na Morawach i v Morawskiej czesci Slaska v XVII-XLIX wieku,

    Czech Academy of Sciences Publication Activity Database

    Freemanová, Michaela

    Vol. III. Wroclaw: Polskie stowarzyszenie pedagogow spiewu - Akademia muzyczna im. Karola Lipinskiego we Wroclawiu, 2005 - (Sasiadek,, E.; Werner, B.), s. 219-228. (Wokalistyka i Pedagogika Wokalna. IV). ISBN 83-86534-37-0. [Sesja naukowa Muzyka. Wroclaw (PL), 04.04.2000] Institutional research plan: CEZ:AV0Z9058907 Keywords : Oratorio * Bohemia * Silesia Subject RIV: AL - Art, Architecture, Cultural Heritage

  7. Ernst Mach a evoluční pojetí vědy

    Czech Academy of Sciences Publication Activity Database

    Havlík, Vladimír

    Vol. 2. Brno: Masarykova univerzita Brno, 2010 - (Dub, P.; Musilová, J.), s. 206-219 ISBN 978-80-210-4808-9. [Mach - Fyzika - Filosofie. Brno (CZ), 16.05.2008 -] Institutional research plan: CEZ:AV0Z90090514 Keywords : E. Mach * evolutionary epistemology * philosophy of science * empiriocriticism Subject RIV: AA - Philosophy ; Religion

  8. Regard de Jan Patočka sur T.G.Masaryk

    Czech Academy of Sciences Publication Activity Database

    Kohák, Erazim

    Paris: Institut d´études slaves, 2007, s. 211-219 R&D Projects: GA MŠk(CZ) LC06013 Institutional research plan: CEZ:AV0Z90090514 Keywords : Jan Patočka * T. G. Masaryk * Czech Philosophy Subject RIV: AA - Philosophy ; Religion

  9. Flow-induced vibration of circular cylindrical structures

    Energy Technology Data Exchange (ETDEWEB)

    Chen, S.S.

    1985-06-01

    This report summarizes the flow-induced vibration of circular cylinders in quiescent fluid, axial flow, and crossflow, and applications of the analytical methods and experimental data in design evaluation of various system components consisting of circular cylinders. 219 figs., 30 tabs. (JDB)

  10. Anti-Semitism on Campus.

    Science.gov (United States)

    Malaney, Gary D.; Williams, Elizabeth A.

    1994-01-01

    Investigated and compared Jewish (n=219) and non-Jewish (n=197) students' perceptions of the anti-Semitic atmosphere at University of Massachusetts at Amherst. Jewish students were significantly more likely to perceive anti-Semitic environment than were non-Jewish students. Nonetheless, 71.4% of non-Jewish students believed Jewish students were…

  11. Chemical composition of flesh of diploid and triploid population of tench (Tinca tinca, Linnaeus 1758)

    Czech Academy of Sciences Publication Activity Database

    Buchtová, H.; Vorlová, L.; Svobodová, Z.; Flajšhans, Martin

    2005-01-01

    Roč. 50, č. 5 (2005), s. 213-219. ISSN 1212-1819 Institutional research plan: CEZ:AV0Z50450515 Keywords : tench * genome polyploidy * dry matter Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 0.254, year: 2005

  12. The shape variability of human tibial epiphyses in an early medieval Great Moravian population (9th-10th century AD): A geometric morphometric assessment

    Czech Academy of Sciences Publication Activity Database

    Brzobohatá, Hana; Krajíček, V.; Velemínský, P.; Poláček, Lumír; Velemínská, J.

    2014-01-01

    Roč. 71, č. 3 (2014), s. 219-236. ISSN 0003-5548 Grant ostatní: GA UK(CZ) 613012 Institutional support: RVO:67985912 ; RVO:68081758 Keywords : geometric morphometrics * tibia * sex ual dimorphism * Great Moravian Empire * Early Middle Ages * socioeconomic status * optical scanning Subject RIV: AC - Archeology, Anthropology, Ethnology Impact factor: 0.250, year: 2014

  13. More Abstracts on Effects of Radiation on Electronic Devices

    Science.gov (United States)

    Bouquet, Frank L.

    1987-01-01

    Second volume of bibliography summarizes literature on radiation effects on new electronic devices. Includes those of protons, electrons, neutrons, gamma rays, and cosmic rays at energies up to about 20 GeV. Volume contains 219 abstracts from unclassified sources. Organized into four sections: dose-rate effects, new technology, post-irradiaton effects, and test environments.

  14. Analysis of major histocompatibility complex class II gene in water voles using capillary electrophoresis-single stranded conformation polymorphism

    Czech Academy of Sciences Publication Activity Database

    Bryja, Josef; Galan, M.; Charbonnel, N.; Cosson, J.-F.

    2005-01-01

    Roč. 5, č. 1 (2005), s. 173-176. ISSN 1471-8278 Institutional research plan: CEZ:AV0Z6093917 Keywords : water vole * population genetics Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 1.219, year: 2005

  15. What Do Employers Ask for in Advertisements for Special Education Positions?

    Science.gov (United States)

    Stephenson, Jennifer; Carter, Mark

    2014-01-01

    Although qualified special educators are more likely to provide effective teaching for students with disabilities and special education needs, it seems many teachers in special education and support positions are not qualified for this role. The study reported here provided analysis of 219 job advertisements for special education positions in…

  16. Electrochemical Evidence of Host-Guest Interactions. Change of Redox Mechanism of Fungicides Iprodione and Procymidone in the Nano-cavity of Cyclodextrins

    Czech Academy of Sciences Publication Activity Database

    Hromadová, Magdaléna; Pospíšil, Lubomír; Giannarelli, S.; Fuoco, R.; Colombini, M. P.

    2002-01-01

    Roč. 73, - (2002), s. 213-219. ISSN 0026-265X R&D Projects: GA MŠk OC D15.10; GA ČR GP203/02/P082 Institutional research plan: CEZ:AV0Z4040901 Keywords : electrochemical evidence * fungicide * cyclodextrin Subject RIV: CG - Electrochemistry Impact factor: 1.325, year: 2002

  17. Comorbidity of Migraine with ADHD

    Science.gov (United States)

    Fasmer, Ole Bernt; Riise, Trond; Lund, Anders; Dilsaver, Steven C.; Hundal, Oivind; Oedegaard, Ketil J.

    2012-01-01

    Objective: The purpose of this study was to investigate how often drugs used to treat migraine and ADHD are prescribed to the same patients to assess, indirectly, the comorbidity of these disorders. Method: We used data from the Norwegian prescription database for 2006, including the total Norwegian population (N = 4,640,219). Results:…

  18. Geochronology and characteristics of Ni-Cu-(PGE) mineralization at Rožany, Lusatian Granitoid Complex, Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Haluzová, Eva; Ackerman, Lukáš; Pašava, J.; Jonášová, Šárka; Svojtka, Martin; Hrstka, Tomáš; Veselovský, F.

    2015-01-01

    Roč. 60, č. 4 (2015), s. 219-236. ISSN 1802-6222 R&D Projects: GA ČR GA13-15390S Institutional support: RVO:67985831 Keywords : Ni-Cu-(PGE) * Lusatia * Re-Os * Bohemian Massif * sulphur Subject RIV: DD - Geochemistry Impact factor: 1.405, year: 2014

  19. Measurement of dose equivalent distribution on-board commercial jet aircraft

    Czech Academy of Sciences Publication Activity Database

    Kubančák, Ján; Ambrožová, Iva; Ploc, Ondřej; Pachnerová Brabcová, Kateřina; Štěpán, Václav; Uchihori, Y.

    2014-01-01

    Roč. 162, č. 3 (2014), s. 215-219. ISSN 0144-8420 Institutional support: RVO:61389005 Keywords : aircrew dosimetry * space weather * CERF Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders Impact factor: 0.913, year: 2014

  20. Increased expression of chemokine receptors CCR1 and CCR3 in nasal polyps: molecular basis for recruitment of the granulocyte infiltrate

    Czech Academy of Sciences Publication Activity Database

    Fundová, Petra; Funda, David; Kovář, D.; Holý, R.; Navara, M.; Tlaskalová-Hogenová, Helena

    2013-01-01

    Roč. 58, č. 3 (2013), s. 219-224. ISSN 0015-5632 R&D Projects: GA MZd NS10054 Institutional support: RVO:61388971 Keywords : INTESTINAL EPITHELIAL-CELLS * GM-CSF * TOLL-LIKE RECEPTORS Subject RIV: EE - Microbiology, Virology Impact factor: 1.145, year: 2013

  1. Predictors of Summer Sun Safety Practice Intentions among Rural High School Students

    Science.gov (United States)

    Cho, Hyunyi; Sands, Laura P.; Wilson, Kari M.

    2010-01-01

    To investigate the association between theoretically grounded psychosocial motivators and the sun safety practice intentions of rural youth. Method: A survey was given to 219 members of FFA (Future Farmers of America) at high schools in the rural Midwest (average age = 16). Results: Perceived self-efficacy, peer norms, response efficacy, and…

  2. Are We Still Afraid of Science?

    Czech Academy of Sciences Publication Activity Database

    Chvatík, Ivan

    Cham: Springer, 2015 - (Učník, L.; Chvatík, I.; Williams, A.), s. 211-219. (Contributions To Phenomenology. 76). ISBN 978-3-319-09827-2 Institutional support: RVO:67985955 Keywords : Hawking * grand design * multiverse theory * brain * free will * quantum fluctuation Subject RIV: AA - Philosophy ; Religion

  3. Thermally stimulated luminescence in Ce-doped yttrium oxyorthosilicate

    Czech Academy of Sciences Publication Activity Database

    Mihóková, Eva; Vávrů, K.; Horodyský, P.; Chewpraditkul, W.; Jarý, Vítězslav; Nikl, Martin

    2012-01-01

    Roč. 59, č. 5 (2012), s. 2085-2088. ISSN 0018-9499 R&D Projects: GA AV ČR KAN300100802 Institutional research plan: CEZ:AV0Z10100521 Keywords : oxide compounds * scintillation detectors * thermoluminescence Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.219, year: 2012

  4. Reduced chemical kinetic mechanisms for NOx emission prediction in biomass combustion

    DEFF Research Database (Denmark)

    Houshfar, Ehsan; Skreiberg, Øyvind; Glarborg, Peter;

    2012-01-01

    reactions and chemical species, that is, 35 species and 198 reactions, corresponding to 72% reduction in the number of reactions and, therefore, improving the computational time considerably. Yet, the model based on the reduced mechanism predicts correctly concentrations of NOx and CO that are essentially...... parameters on NOx emission. © 2012 Wiley Periodicals, Inc. Int J Chem Kinet 44: 219–231, 2012...

  5. The supernumerary cheek tooth in tabby/EDA mice-a reminiscence of the premolar in mouse ancestors

    Czech Academy of Sciences Publication Activity Database

    Peterková, Renata; Lesot, H.; Viriot, L.; Peterka, Miroslav

    2005-01-01

    Roč. 50, - (2005), s. 219-225. ISSN 0003-9969 R&D Projects: GA MŠk OC B23.002; GA ČR GA304/02/0448 Institutional research plan: CEZ:AV0Z5039906 Keywords : supernumerary tooth * molar * odontogenesis Subject RIV: EA - Cell Biology Impact factor: 1.288, year: 2005

  6. 36 CFR 228.102 - Leasing analyses and decisions.

    Science.gov (United States)

    2010-07-01

    ... at 43 CFR parts 1500-1508, and Forest Service implementing policies and procedures set forth in... accordance with the requirements of 36 CFR part 219 (Forest land and resource management planning) and/or, as... there is significant new information or circumstances as defined by 40 CFR 1502.9 requiring...

  7. Thermostability of multidomain proteins: chimeric mesophilic/thermophilic elongation factors EF-Tu

    Czech Academy of Sciences Publication Activity Database

    Šanderová, Hana; Maloň, Petr; Hůlková, Marta; Jonák, Jiří

    Oxford : Blackwell Publishing, 2004, s. 219. [Meeting of the Federation of the European Biochemical Societies /29./. Varšava (PL), 26.06.2004-01.07.2004] R&D Projects: GA ČR GA303/02/0689 Institutional research plan: CEZ:AV0Z5052915 Keywords : thermostability * EF-Tu * chimeric protein Subject RIV: EB - Genetics ; Molecular Biology

  8. Odešla Libuše Hynková

    Czech Academy of Sciences Publication Activity Database

    Stavělová, Daniela

    2012-01-01

    Roč. 22, č. 3 (2012), s. 219-220. ISSN 0862-8351 Institutional support: RVO:68378076 Keywords : Libuše Hynková * necrologue * dance * staging folklor * choreografy of traditional dance Subject RIV: AC - Archeology, Anthropology, Ethnology

  9. VYUŽITÍ ELEKTROCHEMICKÉ IMPEDANČNÍ SPEKTROSKOPIE PRO OBJASNĚNÍ ELEKTROCHEMICKÝCH VLASTNOSTÍ SMĚSÍ LECITINU A CHOLESTEROLU V MODELOVÝCH FOSFOLIPIDOVÝCH MEMBRÁNÁCH

    Czech Academy of Sciences Publication Activity Database

    Nováková, Kateřina; Navrátil, Tomáš; Šestáková, Ivana; Mareček, Vladimír; Chýlková, J.

    2014-01-01

    Roč. 108, č. 3 (2014), s. 219-225. ISSN 0009-2770 R&D Projects: GA ČR(CZ) GAP208/12/1645; GA ČR GA13-21704S Institutional support: RVO:61388955 Keywords : lecitine * cholesterol * biological membranes Subject RIV: CG - Electrochemistry Impact factor: 0.272, year: 2014

  10. 18 CFR 2.1c - Policy statement on consultation with Indian tribes in Commission proceedings.

    Science.gov (United States)

    2010-04-01

    ... (3) Is filed with the Secretary of the Commission. See generally 18 CFR 2.19. Statements of General..., administer justice, and manage and control their lands and resources. Through several Executive Orders and a... Commission's licensing and certificating processes and of the Commission's review of jurisdictional...

  11. Performance of Hamamatsu 64-anode photomultipliers for use with wavelength-shifting optical fibres

    International Nuclear Information System (INIS)

    Hamamatsu R5900-00-M64 and R7600-00-M64 photomultiplier tubes will be used with wavelength-shifting optical fibres to read out scintillator strips in the MINOS near detector. We report on measurements of the gain, efficiency, linearity, crosstalk, and dark noise of 232 of these PMTs, of which 219 met MINOS requirements

  12. 77 FR 74204 - Notice of Availability of the Record of Decision for the Final White-Tailed Deer Management Plan...

    Science.gov (United States)

    2012-12-13

    ... National Park Service Notice of Availability of the Record of Decision for the Final White-Tailed Deer...) announces the availability of the Record of Decision (ROD) for the Final White-tailed Deer Management Plan... (219) 395-1550. SUPPLEMENTARY INFORMATION: The NPS has issued a ROD for the Final White-tailed...

  13. Dialogičnost narativně-biografického interview

    Czech Academy of Sciences Publication Activity Database

    Kubáčková, Patricie

    Praha: ÚJČ AV Ř, 2005 - (Čmejrková, S.; Svobodová, I.), s. 219-235 ISBN 80-86496-23-6 R&D Projects: GA ČR GD405/03/H053 Institutional research plan: CEZ:AV0Z90610518 Keywords : narrative interview * sociolinguistics * ethnomethodology * phatic function Subject RIV: AI - Linguistics

  14. Domain Modeling: NP_003411.3 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_003411.3 chr3 CRYSTAL STRUCTURE OF A DESIGNED ZINC FINGER PROTEIN BOUND TO DNA c1meyf_ chr3/NP_003411.3.../NP_003411.3_holo_219-301.pdb blast 224C,226V,227C,228G,229K,230G,231F,232S,233Q,234S

  15. Domain Modeling: NP_001561.3 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_001561.3 chr3 Structural Basis for the Interaction of TAK1 Kinase with its Activ...ating Protein TAB1 p2evaa_ chr3/NP_001561.3/NP_001561.3_holo_194-543.pdb psi-blast 216I,217S,218Q,219G,224V,

  16. File list: His.Liv.10.AllAg.Liver [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.Liv.10.AllAg.Liver mm9 Histone Liver Liver SRX591723,SRX591725,SRX591727,SRX219...0338,SRX100343 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.Liv.10.AllAg.Liver.bed ...

  17. Dense Alternating Sign Matrices and Extensions

    Czech Academy of Sciences Publication Activity Database

    Fiedler, Miroslav; Hall, F.J.; Stroev, M.

    2014-01-01

    Roč. 444, 1 March (2014), s. 219-226. ISSN 0024-3795 Institutional support: RVO:67985807 Keywords : alternating sign matrix * dense matrix * totally unimodular matrix * combined matrix * generalized complementary basic matrix Subject RIV: BA - General Mathematics Impact factor: 0.939, year: 2014

  18. Complex Wedge-Shaped Matrices: A Generalization of Jacobi Matrices

    Czech Academy of Sciences Publication Activity Database

    Hnětynková, Iveta; Plešinger, M.

    2015-01-01

    Roč. 487, 15 December (2015), s. 203-219. ISSN 0024-3795 R&D Projects: GA ČR GA13-06684S Keywords : eigenvalues * eigenvector * wedge-shaped matrices * generalized Jacobi matrices * band (or block) Krylov subspace methods Subject RIV: BA - General Mathematics Impact factor: 0.939, year: 2014

  19. Word Problem for Knotted Residuated Lattices

    Czech Academy of Sciences Publication Activity Database

    Horčík, Rostislav

    2015-01-01

    Roč. 219, č. 5 (2015), s. 1548-1563. ISSN 0022-4049 R&D Projects: GA ČR GAP202/11/1632 Institutional support: RVO:67985807 Keywords : residuated lattice * knotted rule * word problem * residuated frame * semi-Thue system * square-free word Subject RIV: BA - General Mathematics Impact factor: 0.474, year: 2014

  20. File list: Oth.Dig.20.VSV-G.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Dig.20.VSV-G.AllCell hg19 TFs and others VSV-G Digestive tract SRX961218,SRX961...219 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.Dig.20.VSV-G.AllCell.bed ...

  1. File list: Oth.Dig.05.VSV-G.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Dig.05.VSV-G.AllCell hg19 TFs and others VSV-G Digestive tract SRX961218,SRX961...219 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.Dig.05.VSV-G.AllCell.bed ...

  2. File list: Oth.Dig.50.VSV-G.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Dig.50.VSV-G.AllCell hg19 TFs and others VSV-G Digestive tract SRX961218,SRX961...219 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.Dig.50.VSV-G.AllCell.bed ...

  3. File list: Oth.Dig.10.VSV-G.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Dig.10.VSV-G.AllCell hg19 TFs and others VSV-G Digestive tract SRX961218,SRX961...219 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.Dig.10.VSV-G.AllCell.bed ...

  4. Voltage clamp analysis of ajmaline-induced block of potassium currents in ventricular myocytes

    Czech Academy of Sciences Publication Activity Database

    Bahníková, M.; Matějovič, P.; Pásek, Michal; Šimurdová, M.; Šimurda, J.

    Brno : Brno University of Technology, 2002 - (Jan, J.; Kozumplík, J.; Provazník, I.), s. 217-219 ISBN 80-214-2633-0. ISSN 1211-412X. [Biosignal 2002. Brno (CZ), 26.06.2002-28.06.2002] Institutional research plan: CEZ:AV0Z2076919 Keywords : cardiac cell * potassium currents * ajmaline Subject RIV: BO - Biophysics

  5. Setting up a STAR Tier 2 Site at Golias/Prague Farm

    Czech Academy of Sciences Publication Activity Database

    Chaloupka, Petr; Jakl, Pavel; Kapitán, Jan; Zerola, Michal; Lauret, J.

    Vol. 219. Bristol : IOP Publishing Ltd, 2010 - (Gruntorad, J.; Lokajíček, M.), 072031 ISSN 1742-6588. [17th International Conference on Computing in High Energy and Nuclear Physics (CHEP). Prague (CZ), 21.05.2009-27.05.2009] Institutional support: RVO:61389005 Keywords : STAR Collaboration * RHIC * High Energy Nuclear Physics Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders

  6. Mechanisms and evolution of deceptive pollination in orchids

    Czech Academy of Sciences Publication Activity Database

    Jersáková, Jana; Johnson, S.D.; Kindlmann, Pavel

    2006-01-01

    Roč. 81, - (2006), s. 219-235. ISSN 1464-7931 Institutional research plan: CEZ:AV0Z60870520 Keywords : cross-pollination * floral deception * geitonogamy * inbreeding * nectar * Orchidaceae * pollinaria * reward * self-pollination Subject RIV: EF - Botanics Impact factor: 5.565, year: 2006

  7. Magnetic beads-based electrochemical immunosensor for monitoring allergenic food proteins

    Czech Academy of Sciences Publication Activity Database

    Čadková, M.; Metelka, R.; Holubová, L.; Horák, Daniel; Dvořáková, V.; Bílková, Z.; Korecká, L.

    2015-01-01

    Roč. 484, 1 September (2015), s. 4-8. ISSN 0003-2697 R&D Projects: GA ČR GAP206/12/0381 Institutional support: RVO:61389013 Keywords : electrochemical immunosensor * magnetic particles * ovalbumin Subject RIV: CB - Analytical Chemistry, Separation Impact factor: 2.219, year: 2014

  8. Genomic inbreeding and relationships among Holsteins, Jerseys, and Brown Swiss

    Science.gov (United States)

    Genomic measures of relationship and inbreeding within and across breeds were compared with pedigree measures using genotypes for 43,385 loci of 25,219 Holsteins, 3,068 Jerseys, and 872 Brown Swiss. Adjustment factors were estimated for means and regressions of genomic on pedigree relationships, for...

  9. 76 FR 13631 - Food and Drug Administration Modernization Act of 1997: Modifications to the List of Recognized...

    Science.gov (United States)

    2011-03-14

    .... Radiology 12-122 12-217 IEC 62083 Edition Withdrawn and 2.0:2009-09 Medical replaced with electrical newer... lens design modifications. H. Radiology 12-219 Medical electrical IEC 60336 (Fourth equipment--X-ray... of February 25, 1998 (63 FR 9561), FDA announced the availability of a guidance...

  10. The Division III Student-Athlete: Academic Performance, Campus Involvement and Growth.

    Science.gov (United States)

    Richard, Shaunette; Aries, Elizabeth

    1999-01-01

    A study of 219 seniors, including a broad spectrum of student-athletes, at a Division III school revealed that athletic participation did not impede academic success, or prevent involvement in most other extracurricular activities or with nonathletes. Athletes' personal growth was positively related to time spent with teammates in games and…

  11. Board Members' Views on Training and Development.

    Science.gov (United States)

    Weaver, Liz; Inglis, Sue

    1999-01-01

    A survey of 22 agency directors and 219 volunteer board members showed that 40% of members received 1-5 hours of training in the last 6 months, 47% none. Training needs included board roles and responsibilities, strategic planning, understanding the agency, and fundraising. Preferred methods were facilitated workshop/retreat or board-led training…

  12. 77 FR 57079 - National Board for Education Sciences; Meeting

    Science.gov (United States)

    2012-09-17

    ... National Board for Education Sciences; Meeting AGENCY: Institute of Education Sciences, Department of... agenda of an upcoming meeting of the National Board for Education Sciences. The notice also describes the...:(202) 219-1466; email: Monica.Herk@ed.gov . SUPPLEMENTARY INFORMATION: The National Board for...

  13. Legal and Illegal Colours

    DEFF Research Database (Denmark)

    Larsen, John Christian

    2008-01-01

    ://www.efsa.europa.eu/EFSA/efsa_locale-1178620753812_1178620765743.htm. Accessed 12.05.08.] and parabens [EFSA. (2004). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) related to para hydroxybenzoates (214e219). Opinion expressed on 13/07/2004. Available at http...

  14. Development and validation of a prognostic model for recurrent glioblastoma patients treated with bevacizumab and irinotecan

    DEFF Research Database (Denmark)

    Urup, Thomas; Dahlrot, Rikke Hedegaard; Grunnet, Kirsten;

    2016-01-01

    . MATERIAL AND METHODS: A total of 219 recurrent GBM patients treated with BEV plus irinotecan according to a previously published treatment protocol were included in the initial population. Prognostic models were generated by means of multivariate logistic and Cox regression analysis. RESULTS: In...

  15. Main: 1WEE [RPSD[Archive

    Lifescience Database Archive (English)

    Full Text Available 1WEE シロイヌナズナ Arabidopsis Arabidopsis thaliana (L.) Heynh. Hypothetical Protein F10c21.9 N ... 1g33420; Arabidopsis Thaliana Molecule: Phd Finger Family ... Protein; Chain: A; Fragment: Phd Domain; Engineere ... ama Solution Structure Of Phd Domain In Phd Finger Family ... Protein To Be Published Nmr, Structural Genomics, ...

  16. 75 FR 13422 - Federal Acquisition Regulation; FAR Case 2008-015, Payments Under Fixed-Price Architect-Engineer...

    Science.gov (United States)

    2010-03-19

    ... services work. Discussion and Analysis A proposed rule was published in the Federal Register at 74 FR 20666... Federal Acquisition Regulation; FAR Case 2008-015, Payments Under Fixed-Price Architect-Engineer Contracts.... Suzanne Neurauter, Procurement Analyst, at 202-219-0310. For information pertaining to status...

  17. 36 CFR 251.56 - Terms and conditions.

    Science.gov (United States)

    2010-07-01

    ... plan governing the area (36 CFR part 219). (c) Preconstruction approvals. Forest Service approval of... Special Uses § 251.56 Terms and conditions. (a) General. (1) Each special use authorization must contain... and economic interests; (B) Manage efficiently the lands subject to the use and adjacent thereto;...

  18. The Genetic and Environmental Covariation among Psychopathic Personality Traits, and Reactive and Proactive Aggression in Childhood

    Science.gov (United States)

    Bezdjian, Serena; Tuvblad, Catherine; Raine, Adrian; Baker, Laura A.

    2011-01-01

    The present study investigated the genetic and environmental covariance between psychopathic personality traits with reactive and proactive aggression in 9- to 10-year-old twins (N = 1,219). Psychopathic personality traits were assessed with the Child Psychopathy Scale (D. R. Lynam, 1997), while aggressive behaviors were assessed using the…

  19. Response of photosynthetic apparatus of spring barley (Hordeum vulgare L.) to combined effect of elevated CO2 concentration and different growth irradiances

    Czech Academy of Sciences Publication Activity Database

    Kurasová, I.; Kalina, J.; Štroch, M.; Urban, Otmar; Špunda, V.

    2003-01-01

    Roč. 41, č. 2 (2003), s. 209-219. ISSN 0300-3604 R&D Projects: GA ČR GA522/00/1381; GA MŠk LN00A141 Institutional research plan: CEZ:AV0Z6087904 Keywords : CO2 concentration * fluorescence * photosynthesis Subject RIV: ED - Physiology Impact factor: 0.661, year: 2003

  20. Pöökpuud kuupaisel : [luuletused] / L{u00E1szl̤ Nagy ; tlk. Ly Seppel, Andres Ehin

    Index Scriptorium Estoniae

    Nagy, L{u00E1szl̤

    2004-01-01

    Sisu: Pöökpuud kuupaistel ; Härmaehtes maipidu ; Kes kannab siis teisele kaldale armastuse? ; Linna vapp ; Haljas ingel ; Bart̤k ja kiskjad ; Pulmad ; Ümbersünd hõbedasse ; Elagu puud. Eluloolisi andmeid autori kohta lk. 219-220

  1. Utility of the Rosenberg Self-Esteem Scale

    Science.gov (United States)

    Davis, Clare; Kellett, Stephen; Beail, Nigel

    2009-01-01

    The Rosenberg Self-Esteem Scale (RSES) continues to be used to purportedly measure self-esteem of people with intellectual disabilities, despite the lack of sound evidence concerning its validity and reliability when employed with this population. The psychometric foundations of the RSES were analyzed here with a sample of 219 participants with…

  2. What Proportion of Preschool-Aged Children Consume Sweetened Beverages?

    Science.gov (United States)

    Nickelson, Jen; Lawrence, Jeannine C.; Parton, Jason M.; Knowlden, Adam P.; McDermott, Robert J.

    2014-01-01

    Background: Obesity affects nearly 17% of US children and youth 2-19?years old and 10% of infants and toddlers under the age of 2?years. One strategy for addressing obesity is to discourage sugar-sweetened beverage (SSB) consumption. Compared with their older school-aged counterparts, children =5?years depend largely on parents for the purchase…

  3. Endogenous development, pathogenicity and host specificity of Eimeria cahirinensis Couch, Blaustein, Duszynski, Shenbrot and Nevo, 1997 (Apicomplexa: Eimeriidae) from Acomys dimidiatus (Cretzschmar 1826) (Rodentia: Muridae) from the Near East

    Czech Academy of Sciences Publication Activity Database

    Kvičerová, Jana; Ptáčková, P.; Modrý, David

    2007-01-01

    Roč. 100, č. 2 (2007), s. 219-226. ISSN 0932-0113 R&D Projects: GA ČR GA524/03/1548 Institutional research plan: CEZ:AV0Z60220518 Keywords : Eimeria cahirinensis * Acomys * Near East Subject RIV: EG - Zoology Impact factor: 1.512, year: 2007

  4. Integrating Nutrition into the Physical Education Curriculum

    Science.gov (United States)

    Green, Heather L.

    2012-01-01

    Obesity among children and teens continues to be a major public health concern in the United States. Approximately 16.9% of children and adolescents age 2-19 years are obese. To address this epidemic, schools have been encouraged to develop a coordinated school health program, which includes an interdisciplinary approach to nutrition education.…

  5. Deviates' External Status and Opinion Patterns: Effects on Influence, Attractiveness, and Perceived Rationale.

    Science.gov (United States)

    Ruback, R. Barry; Gromme, Marcia A.

    1989-01-01

    Manipulated external status of a target by presenting person as ethnic majority female, ethnic minority male, or ethnic majority male discussing issue with four ethnic majority males. Subjects were college students (N=219). Results were consistent with previous research showing odd person in a group is more salient than other group members. (ABL)

  6. Biophysical insights into cancer transformation and treatment

    Czech Academy of Sciences Publication Activity Database

    Pokorný, Jiří; Foletti, A.; Kobilková, J.; Jandová, Anna; Vrba, J.; Vrba, J. jr.; Nedbalová, M.; Čoček, A.; Danani, A.; Tuszynski, J. A.

    2013-01-01

    Roč. 2013, č. 195028 (2013). ISSN 1537-744X R&D Projects: GA ČR(CZ) GAP102/11/0649 Institutional support: RVO:67985882 Keywords : fatty acid * mitochondrial membrane * cancer cell Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering Impact factor: 1.219, year: 2013

  7. Family Engagement in Literacy Activities: Revised Factor Structure for the Familia--An Instrument Examining Family Support for Early Literacy Development

    Science.gov (United States)

    Buhs, Eric S.; Welch, Greg; Burt, Jennifer; Knoche, Lisa

    2011-01-01

    This study evaluated a data-set drawn using "The Familia"--a measure originally developed to evaluate shared-reading activities. A newly developed set of conceptual supports and a confirmatory factor analysis (CFA) were applied to a new factor structure/model. Data were drawn from 219 young children and their families (mean age = 43 months)…

  8. Flow-induced vibration of circular cylindrical structures

    International Nuclear Information System (INIS)

    This report summarizes the flow-induced vibration of circular cylinders in quiescent fluid, axial flow, and crossflow, and applications of the analytical methods and experimental data in design evaluation of various system components consisting of circular cylinders. 219 figs., 30 tabs

  9. Odkaz Viktora Knappa české civilistice

    Czech Academy of Sciences Publication Activity Database

    Eliáš, Karel

    Plzeň: Aleš Čeněk, 2014 - (Gerloch, A.), s. 219-233 ISBN 978-80-7380-509-8 Institutional support: RVO:68378122 Keywords : eminent lawyer * civil law * theory of law Subject RIV: AG - Legal Sciences

  10. Effects of Welfare Participation on Marriage

    Science.gov (United States)

    Teitler, Julien O.; Reichman, Nancy E.; Nepomnyaschy, Lenna; Garfinkel, Irwin

    2009-01-01

    We investigated the widely held premise that welfare participation causes women to refrain from marriage. Using data from the Fragile Families and Child Wellbeing Study (N = 3,219), we employed an event history approach to study transitions to marriage among mothers who have had a nonmarital birth. We found that welfare participation reduces the…

  11. What Can We Learn from Toddlers about Categorical Perception of Color? Comments on Goldstein, Davidoff, and Roberson

    Science.gov (United States)

    Franklin, Anna; Wright, Oliver; Davies, Ian R. L.

    2009-01-01

    We comment on Goldstein, Davidoff, and Roberson's replication and extension ("Journal of Experimental Child Psychology, 102", 219-238 [2009]) of our study of the effect of toddlers' color term knowledge on their categorical perception (CP) of color ("Journal of Experimental Child Psychology, 90", 114-141 [2005]). First, we discuss how best to…

  12. Cognitive and Adaptive Functioning in 28 Girls with Rett Syndrome. Brief Report.

    Science.gov (United States)

    Perry, Adrienne; And Others

    1991-01-01

    This study of 28 girls (ages 2-19) with Rett Syndrome found profound handicaps in the intellectual and adaptive areas, according to standardized tests. Subjects seemed capable of learning some self-help skills at a basic level. The Cattell Mental Age was significantly negatively correlated with chronological age. (JDD)

  13. Electrochemically initiated degradation of a new energetic material 2,2-dinitroethene-1,1-diamine (FOX-7)

    Czech Academy of Sciences Publication Activity Database

    Šimková, Ludmila; Ludvík, Jiří

    Montréal : ECS, 2011. [ECS Meeting /219./. 01.05.2011-06.05.2011, Montreal] R&D Projects: GA ČR GAP206/11/0727 Institutional research plan: CEZ:AV0Z40400503 Keywords : electrochemistry * 2,2-dinitroethene-1,1-diamine Subject RIV: CG - Electrochemistry

  14. Management of upper gastrointestinal bleeding from portal hypertension: Elective or emergency operation?

    OpenAIRE

    Liu, Sen

    2014-01-01

    Objective : To evaluate the clinical outcome of emergency and elective operation of splenectomy with periesophagogastric devascularization in treating upper gastrointestinal hemorrhage resulted from portal hypertension. Methods : We retrospectively reviewed 219 patients of upper gastrointestinal hemorrhage resulted from portal hypertension treated using emergency or elective operation between Jul 2002 and Aug 2010. The clinical data were collected and analyzed. Results : In the group of elect...

  15. Polyimide based membranes for gas separation

    Czech Academy of Sciences Publication Activity Database

    Martin-Gil, V.; Sysel, P.; Hrabánek, Pavel; Fíla, V.

    Praha : VŠCHT Praha, 2014 - (Bouzek, K.), s. 216-219 ISBN 978-80-7080-889-4. [Moderní trendy v anorganických technologiích 2014 /4./. Praha (CZ), 11.06.2014-13.06.2014] Institutional support: RVO:61388955 Keywords : membrane synthesis * gas separation * copolyimide Subject RIV: CF - Physical ; Theoretical Chemistry

  16. Couples at risk following the death of their child : predictors of grief versus depression

    NARCIS (Netherlands)

    Wijngaards-de Meij, Leoniek; Stroebe, Margaret; Schut, Henk; Stroebe, Wolfgang; van den Bout, Jan; van der Heijden, Peter; Dijkstra, Iris

    2005-01-01

    This longitudinal study examined the relative impact of major variables for predicting adjustment (in terms of both grief and depression) among bereaved parents following the death of their child. Couples (N = 219) participated 6, 13, and 20 months postloss. Use of multilevel regression analyses ena

  17. Tertiary Structures of the Escherichia coli and Human Chromosome 21 Molecules of DNA

    Czech Academy of Sciences Publication Activity Database

    Hanzálek, Petr; Kypr, Jaroslav

    2001-01-01

    Roč. 283, č. 1 (2001), s. 219-223. ISSN 0006-291X R&D Projects: GA AV ČR IAA5004802 Institutional research plan: CEZ:AV0Z5004920 Keywords : DNA crystal structure s * phosphorus atom representation * genomic DNA molecules Subject RIV: BO - Biophysics Impact factor: 2.946, year: 2001

  18. Longitudinal Models of Socio-Economic Status: Impact on Positive Parenting Behaviors

    Science.gov (United States)

    Azad, Gazi; Blacher, Jan; Marcoulides, George

    2014-01-01

    Parenting research is frequently conducted without a thorough examination of socio-economic characteristics. In this study, longitudinal observations of positive parenting were conducted across six time points. Participants were 219 mothers of children with and without developmental delays. Mothers' positive parenting increased during early…

  19. Three anisotropic benchmark problems for adaptive finite element methods

    Czech Academy of Sciences Publication Activity Database

    Šolín, Pavel; Čertík, O.; Korous, L.

    2013-01-01

    Roč. 219, č. 13 (2013), s. 7286-7295. ISSN 0096-3003 R&D Projects: GA AV ČR IAA100760702 Institutional support: RVO:61388998 Keywords : benchmark problem * anisotropic solution * boundary layer Subject RIV: BA - General Mathematics Impact factor: 1.600, year: 2013

  20. Papel de las células NK y linfocitos T en la respuesta inmune frente a Chlamidophyla abortus en modelo murino / Carlos Manuel Martínez Cacéres; directores, Joaquín Sánchez Campillo, Antonio J. Buendía Marín y Jesús Salinas Lorente.

    OpenAIRE

    Martínez Cáceres, Carlos Manuel

    2006-01-01

    Tesis-Universidad de Murcia. Consulte la tesis en: BCA. GENERAL. ARCHIVO UNIVERSITARIO. T.M. 3026. Consulte la tesis en: BCA. GENERAL. Fac. Veterinaria. Departamentos. E002B TESIS 111. Consulte la tesis en: BCA. GENERAL. Fac. Veterinaria. Sala de estudio. Tesis-V 219.

  1. Activities and Accomplishments in Various Domains: Relationships with Creative Personality and Creative Motivation in Adolescence

    Science.gov (United States)

    Hong, Eunsook; Peng, Yun; O'Neil, Harold F., Jr.

    2014-01-01

    This study examined relationships between five personal traits and adolescents' creative activities and accomplishments in five domains--music, visual arts, creative writing, science, and technology. Participants were 439 tenth graders (220 males and 219 females) in China. The relationships were examined using confirmatory factor analysis.…

  2. THE SCHOOL ADMINISTRATOR AND ORGANIZATIONAL CHARACTER.

    Science.gov (United States)

    MINER, JOHN B.

    TO DETERMINE MAJOR FACTORS AFFECTING SELECTION AND PERFORMANCE OF SUPERVISORS IN SCHOOL ORGANIZATIONS, DATA WERE ANALYZED FROM A SCHOOL ADMINISTRATOR EVALUATION FORM FOR 219 ADMINISTRATIVE PERSONNEL (79.3 PERCENT OF 276 TOTAL), REPRESENTING LARGE CITY, MEDIUM CITY, SMALL CITY, AND CONSOLIDATED SCHOOL DISTRICTS IN THE PACIFIC NORTHWEST. APPLYING…

  3. Vývoj sociální struktury české společnosti 1988-1999

    Czech Academy of Sciences Publication Activity Database

    Machonin, Pavel; Gatnar, Lumír; Tuček, Milan

    Brno : Konvoj, 2000 - (Kučerová, S.), s. 205-219 ISBN 80-7302-000-9 R&D Projects: GA ČR GA403/98/0170 Institutional research plan: CEZ:AV0Z7028912 Keywords : czech society * social transformation * hybrid structure Subject RIV: AO - Sociology, Demography

  4. Palmyra Atoll Site 15P 3/31/2004 38-39M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Onemetersquare 1 meter x 1 meter benthic substrate at Palmyra Atoll, site 15P 05 52.219N, 162 02.697W, between 38 and 39 meters along a permanent transect.

  5. Resources for Increasing Physical Activity in Children and Youth

    Science.gov (United States)

    Ryan, Carol A.; Beighle, Aaron

    2010-01-01

    The number of children and youth who are overweight has reached epidemic proportions in the United States. According to the 2007-2008 National Health and Nutrition Examination Survey (NHANES) conducted by the Centers for Disease Control and Prevention (CDC), an estimated 17 percent of children and adolescents ages 2-19 years are obese. In…

  6. Psychiatric Disorders in Extremely Preterm Children: Longitudinal Finding at Age 11 Years in the EPICure Study

    Science.gov (United States)

    Johnson, Samantha; Hollis, Chris; Kochhar, Puja; Hennessy, Enid; Wolke, Dieter; Marlow, Neil

    2010-01-01

    Objective: To investigate the prevalence and risk factors for psychiatric disorders in extremely preterm children. Method: All babies born less than 26 weeks gestation in the United Kingdom and Ireland from March through December 1995 were recruited to the EPICure Study. Of 307 survivors at 11 years of age, 219 (71%) were assessed alongside 153…

  7. Physical, Social, and Perceived Availabilities of Alcohol and Last Month Alcohol Use in Rural and Small Urban Communities

    Science.gov (United States)

    Stanley, Linda R.; Henry, Kimberly L.; Swaim, Randall C.

    2011-01-01

    This study seeks to provide a greater understanding of the factors that determine the perceived availability of alcohol and its role in predicting adolescents' alcohol use. Participants were 151,703 7th-12th grade students (50% female) from a sample of 219 rural communities across the United States, with oversampling for predominantly…

  8. Optimal Mirrleesean taxation in a Ben-Porath economy

    Czech Academy of Sciences Publication Activity Database

    Kapička, Marek

    2015-01-01

    Roč. 7, č. 2 (2015), s. 219-248. ISSN 1945-7707 R&D Projects: GA ČR(CZ) GA13-29370S Institutional support: PRVOUK-P23 Keywords : optimal taxes * unobservable human capital * income taxes Subject RIV: AH - Economics Impact factor: 3.780, year: 2014

  9. A Study of the Effects of Automation on the Nature of the Work of the Draftsman in Industry, and the Innovative Programs of Instruction for Automated Drafting in Selected Junior Colleges in California to be Used for Curricular Revision. Final Report.

    Science.gov (United States)

    Husung, William T., Jr.

    Visits to 35 industries and professional offices throughout California and interviews of 219 draftsmen and supervisors were conducted to determine: (1) the effects of automation on the needs of industry for draftsmen with general versus specialized training, and (2) the curricular revisions in vocational drafting programs in junior colleges to…

  10. Zicht op vangsten recreatieve visserij : een nieuwe methode en eerste resultaten

    NARCIS (Netherlands)

    Graaf, de M.; Quak, J.

    2012-01-01

    Recreatieve vissers hebben in 2010 naar schatting 382 ton kabeljauw gevangen en daarvan 23 ton teruggezet. Die vangst is ruim tien procent van de commerciele vangst van 3.219 ton door de beroepsvissersvloot dat jaar. De gezamenlijke aalvangst door recreatieve vissers op zee en in binnenwater in 2010

  11. Plasmonic composites of semiconductive polyelectrolytes with metal nanoparticles

    Czech Academy of Sciences Publication Activity Database

    Pfleger, Jiří; Kazim, Samrana; Bondarev, D.; Vohlídal, J.

    Pennington : The Electrochemical Society, 2011. A_1294. [ECS Meeting /219./. 01.05.2011-06.05.2011, Montreal] R&D Projects: GA ČR GAP208/10/0941 Institutional research plan: CEZ:AV0Z40500505 Keywords : plasmonic nanoparticles * polyelectrolytes * conductive polymers Subject RIV: CF - Physical ; Theoretical Chemistry

  12. The Influence of Celebrity Exemplars on College Students' Smoking

    Science.gov (United States)

    Yoo, Woohyun

    2016-01-01

    Objective: This study examined the effect of celebrity smoking exemplars in health news on college students' perceptions of smoking-related health risks and smoking intentions. Participants and Methods: The data were collected using a Web-based survey of 219 undergraduate students at a large midwestern university in March 2011. Separate analyses…

  13. Dicty_cDB: CHN835 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available tical) Pinus taeda cDNA clone NXRV120_G11 5', mRNA sequence. 48 0.22 1 BA000026 |BA...005344.13 Zebrafish DNA sequence from clone CH211-219E17. 40 0.097 2 BQ699205 |BQ699205.1 NXRV120_G11_F NXRV (Nsf Xylem Root wood Ver

  14. Muscle Dysmorphia, Gender Role Stress, and Sociocultural Influences: An Exploratory Study

    Science.gov (United States)

    Readdy, Tucker; Watkins, Patti Lou; Cardinal, Bradley J.

    2011-01-01

    Our study explored the contribution of gender role stress (GRS) and sociocultural appearance demands to symptoms of muscle dysmorphia (MD) in a college sample of 219 women and 154 men. For women, five GRS subscales, sociocultural appearance demands, age, and frequency of aerobic exercise predicted MD symptoms (model R[superscript 2] = 0.33;…

  15. Palmyra Atoll Site 15P 3/31/2004 44-45M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Onemetersquare 1 meter x 1 meter benthic substrate at Palmyra Atoll, site 15P 05 52.219N, 162 02.697W, between 44 and 45 meters along a permanent transect.

  16. Large expansion of morphologically heterogeneous mammary epithelial cells, including the luminal phenotype, from human breast tumours

    Czech Academy of Sciences Publication Activity Database

    Krásná, Luboslava; Dudorkinová, D.; Vedralová, J.; Veselý, Pavel; Pokorná, Eva; Kudláčková, I.; Chaloupková, Alena; Petruželka, L.; Daneš, J.; Matoušková, Eva

    2002-01-01

    Roč. 2002, č. 71 (2002), s. 219-235. ISSN 0167-6806 Institutional research plan: CEZ:AV0Z5052915 Keywords : human breast tumours * in vitro cultivation * keratins Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.132, year: 2002

  17. Sociometry in team assessment and development

    Czech Academy of Sciences Publication Activity Database

    Šlechta, Petr

    Londýn : European Congress of Psychology, 2001. s. 219. [VII. European Congress of Psychology. 05.05.2001-07.05.2001, Londýn] Institutional research plan: CEZ:AV0Z7025918 Keywords : sociometry * teamwork training * team assessment Subject RIV: AN - Psychology

  18. 75 FR 28849 - Review of the Designation of Ansar al-Islam (aka Ansar Al-Sunnah and Other Aliases) as a Foreign...

    Science.gov (United States)

    2010-05-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Review of the Designation of Ansar al-Islam (aka Ansar Al-Sunnah and Other Aliases) as a Foreign Terrorist Organization Pursuant to Section 219 of the Immigration and Nationality Act, as Amended Based upon a review...

  19. Invasive species

    Czech Academy of Sciences Publication Activity Database

    Pyšek, Petr; Richardson, D. M.

    Vol. 5. Great Barrington : Berkshire Publishing Group, 2012 - (Craig, R.; Nagle, J.; Pardy, B.; Schmitz, O.; Smith, W.), s. 211-219 ISBN 978-1-933782-16-4 Institutional support: RVO:67985939 Keywords : plant invasions * invasibility * invasiveness Subject RIV: EF - Botanics

  20. 75 FR 2477 - Plan Development for Kiowa, Rita Blanca, Black Kettle and McClellan Creek National Grasslands...

    Science.gov (United States)

    2010-01-15

    ... using the provisions of the 1982 planning rule. Authority: 16 U.S.C. 1600-1614; 36 CFR 219.35 (74 FR... Grasslands, Colfax, Harding, Mora and Union Counties, NM; Dallam, Gray and Hemphill Counties, TX; Cimarron... applicable planning rule and how work done on the plan revision under the 2008 planning rule will be used...

  1. Fe2O3-SiO2 composites obtained by sol-gel synthesis

    Czech Academy of Sciences Publication Activity Database

    Savii, C.; Popovici, M.; Enache, C.; Šubrt, Jan; Nižňanský, Daniel; Bakardjieva, Snejana; Caizer, C.; Hrianca, I.

    2002-01-01

    Roč. 151, 1-4 (2002), s. 219-227. ISSN 0167-2738 R&D Projects: GA MŠk LN00A028 Institutional research plan: CEZ:AV0Z4032918 Keywords : sol-gel processing * magnetic properties * fine-particle systems Subject RIV: CA - Inorganic Chemistry Impact factor: 1.768, year: 2002

  2. Arginine-, D-arginine-vasopressin, and their inverso analogues in micellar and liposomic models of cell membrane: CD, NMR, and molecular dynamics studies

    Czech Academy of Sciences Publication Activity Database

    Lubecka, E. A.; Sikorska, E.; Sobolewski, D.; Prahl, A.; Slaninová, Jiřina; Ciarkowski, J.

    2015-01-01

    Roč. 44, č. 8 (2015), s. 727-743. ISSN 0175-7571 Institutional support: RVO:61388963 Keywords : antidiuretic agonists * anionic-zwitterionic micelles * liposomes * inverso analogues Subject RIV: CC - Organic Chemistry Impact factor: 2.219, year: 2014 http://link.springer.com/article/10.1007/s00249-015-1071-4/fulltext.html

  3. Palmyra Atoll Site 15P 3/31/2004 89-90M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Palmyra Atoll, site 15P (05 52.219N, 162 02.697W), between 89 and 90 meters along a permanent transect.

  4. Longitudinal Perspectives of Child Positive Impact on Families: Relationship to Disability and Culture

    Science.gov (United States)

    Blacher, Jan; Begum, Gazi F.; Marcoulides, George A.; Baker, Bruce L.

    2013-01-01

    This study examined mothers' perceptions of the positive impact of having a child with an intellectual disability. Trajectories of positive impact from 7 time points were developed using latent growth modeling and 2 predictors: culture (Anglo, Latino) and child disability status (intellectual disability, typical development). Data were from 219

  5. Composition of PM2.5 in Prague during the Year 2006

    Czech Academy of Sciences Publication Activity Database

    Schwarz, Jaroslav; Štefancová, Lucia; Novák, J.; Macek, V.; Smolík, Jiří

    Thessaloniki: Hellenic Association for Aerosol Research, 2008, T06A219P. [European Aerosol Conference 2008. Thessaloniki (GR), 24.08.2008-29.08.2008] Grant ostatní: NF(FI) CZ0049 Institutional research plan: CEZ:AV0Z40720504 Keywords : urban aerosol * chemical composition * carbonaceous particles Subject RIV: CF - Physical ; Theoretical Chemistry

  6. AcEST: BP913319 [AcEST

    Lifescience Database Archive (English)

    Full Text Available YMU001_000028_H11 491 Adiantum capillus-veneris mRNA. clone: YMU001_000028_H11. BP913319 CL4180C ... ives = 43/49 (87%) Frame = -2 Query: 490 GSWITFNQVVEPA IVPPWPLNGYVRGVTAKIVREILGDLQRECIHLAEM 344 GSW+ F QV+ ... NGYVRGVT +I+RE+L DLQ EC+ L+++ Sbjct: 171 GSWVNFQQVLEPA IVPPWPLNGYVRGVTERIIREMLADLQLECLRLSQV 219 >tr|A9TSV5 ...

  7. High levels of nuclear MYC protein predict the presence of MYC rearrangement in diffuse large B-cell lymphoma

    DEFF Research Database (Denmark)

    Green, Tina Marie; Nielsen, Ole; de Stricker, Karin;

    2012-01-01

    with poor prognosis in DLBCL. Fluorescence in situ hybridization and karyotyping are standard tests for detecting MYC aberrations, but these techniques are laborious and expensive. Here, we studied MYC status of 219 DLBCLs and Burkitt lymphomas using fluorescence in situ hybridization, immunohistochemistry...

  8. Quasistatic Delamination of Sandwich-Like Kirchhoff-Love Plates

    Czech Academy of Sciences Publication Activity Database

    Freddi, L.; Roubíček, Tomáš; Zanini, Ch.

    2013-01-01

    Roč. 113, č. 2 (2013), s. 219-250. ISSN 0374-3535 R&D Projects: GA ČR GAP201/10/0357 Institutional research plan: CEZ:AV0Z20760514 Keywords : adhesive contact * delamination * mixed modes Subject RIV: BA - General Mathematics Impact factor: 1.043, year: 2013

  9. Measurement of Perceived Parenting Style Influence on Academic Achievement among Saudi College Students

    Science.gov (United States)

    Alanizi, Faris Mayoof Mokheimer

    2010-01-01

    The purpose of this study was to examine the relation between academic achievement and parenting styles among Saudi college students. The participants in this study consisted of 349 male and 219 female college students, whose age ranged from 18-25 years. The instruments for the current study were: (a) an Arabic translation of the Revised Parental…

  10. Parallel intergrowths in cronstedtite-1T: determination of the degree of disorder

    Czech Academy of Sciences Publication Activity Database

    Hybler, Jiří

    2006-01-01

    Roč. 18, - (2006), s. 197-205. ISSN 0935-1221 R&D Projects: GA ČR(CZ) GA205/03/0439 Institutional research plan: CEZ:AV0Z10100521 Keywords : polytypism * disorder * layer silicate * parallel intergrowth * Durovic effect Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.219, year: 2006

  11. Drug: D02107 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available Indiclor (TN) InCl3 219.8104 221.177 D02107.gif Radioactive agent Therapeutic category: 4300 Therapeutic ca...tegory of drugs in Japan [BR:br08301] 4 Agents affecting cellular function 43 Radioactive drugs 430 Radioactive drugs 4300 Radio

  12. A first experimental test of multilevel game theory: the PD case

    Czech Academy of Sciences Publication Activity Database

    Hausken, K.; Ortmann, Andreas

    2008-01-01

    Roč. 15, č. 4 (2008), s. 261-264. ISSN 1350-4851 R&D Projects: GA MŠk LC542 Institutional research plan: CEZ:MSM0021620846 Keywords : multilevel game theory * prisoner's dilemma Subject RIV: AH - Economics Impact factor: 0.219, year: 2008

  13. 77 FR 14303 - Federal Acquisition Regulation; Women-Owned Small Business (WOSB) Program

    Science.gov (United States)

    2012-03-09

    ... Small Business (WOSB) Program Correction In rule document 2012-4475 appearing on pages 12913 through... Economically Disadvantaged Women-Owned Small Business (EDWOSB) Concerns (APR 2012) (15 U.S.C. 637(m)).'' 4. On...: ``(25) 52.219-30, Notice of Set-Aside for Women-Owned Small Business (WOSB) Concerns Eligible Under...

  14. 75 FR 40019 - In the Matter of the Review of the Designation of the Communist Party of the Philippines/New...

    Science.gov (United States)

    2010-07-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE In the Matter of the Review of the Designation of the Communist Party of the Philippines/New People's Army (aka CPP/NPA and Other Aliases) as a Foreign Terrorist Organization Pursuant to Section 219 of...

  15. Functional and structural diversity of soil microbial communities on colliery spoil heaps

    Czech Academy of Sciences Publication Activity Database

    Malý, S.; Elhottová, Dana; Frouz, Jan; Chroňáková, Alica; Krištůfek, Václav; Kalčík, Jiří; Picek, T.

    Zaragoza : Society for Ecological Restoration International, 2005. s. 219. [The World Conference on Ecological Restoration . 12.09.2005-18.09.2005, Zaragoza] Institutional research plan: CEZ:AV0Z60660521 Keywords : soil microbial community * Czech Republic * environmental factors Subject RIV: EH - Ecology, Behaviour

  16. Plasma blocks from nonlinear force generated skin acceleration for ignition of a fusion flame in nearly uncompressed solid DT

    Czech Academy of Sciences Publication Activity Database

    Hora, H.; Badziak, J.; Glowacz, S.; Jablonski, S.; Wolowski, J.; Skladanowski, Z.; Osman, F.; Cang, Y.; Zhang, J.; Peng, H.; He, X.; Miley, G. H.; Jungwirth, Karel; Rohlena, Karel; Ullschmied, Jiří

    2006-01-01

    Roč. 133, - (2006), s. 219-222. ISSN 1155-4339 R&D Projects: GA MŠk(CZ) LC528 Institutional research plan: CEZ:AV0Z10100523; CEZ:AV0Z20430508 Keywords : picosecond laser-pulses * driven * confinement * compression * densities Subject RIV: BH - Optics, Masers, Lasers Impact factor: 0.315, year: 2006

  17. High precision measurement of the tritium .beta.spectrum near its endpoint and upper limit on the neutrino mass

    Czech Academy of Sciences Publication Activity Database

    Weinheimer, Ch.; Degenddag, B.; Bleile, A.; Bonn, J.; Bornschein, L.; Kazachenko, O.; Kovalík, Alojz; Otten, E. W.

    1999-01-01

    Roč. 460, - (1999), s. 219-226. ISSN 0370-2693 R&D Projects: GA ČR GA202/96/0552; GA AV ČR KSK1048601 Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders Impact factor: 3.878, year: 1999

  18. 36 CFR 223.281 - Monitoring and revising sustainable harvest levels.

    Science.gov (United States)

    2010-07-01

    ... sustainable harvest levels. 223.281 Section 223.281 Parks, Forests, and Public Property FOREST SERVICE....281 Monitoring and revising sustainable harvest levels. The Forest Service shall monitor and revise sustainable harvest levels for forest botanical products in accordance with § 223.219 of subpart G....

  19. Epitaxial re-crystallization of the Ni/MgO(001) interfaces

    Czech Academy of Sciences Publication Activity Database

    Vacík, Jiří; Naramoto, H.; Yamamoto, S.; Narumi, K.

    2004-01-01

    Roč. 219, č. 20 (2004), s. 867-870. ISSN 0168-583X Institutional research plan: CEZ:AV0Z1048901 Keywords : Ni deposition * Mg0(001) substrate * annealing Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 0.997, year: 2004

  20. Study of the nickel-fullerene nano-structured thin films

    Czech Academy of Sciences Publication Activity Database

    Vacík, Jiří; Naramoto, H.; Narumi, K.; Yamamoto, S.; Abe, H.

    2004-01-01

    Roč. 219, č. 20 (2004), s. 862-866. ISSN 0168-583X Institutional research plan: CEZ:AV0Z1048901 Keywords : nickel * fullerene * magnesium oxide Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 0.997, year: 2004