WorldWideScience

Sample records for astatine 219

  1. Bibliography of astatine chemistry and biomedical applications

    International Nuclear Information System (INIS)

    An overall bibliography is presented on astatine chemistry and on the biomedical applications of its 211At isotope. The references were grouped in the following chapters: General reviews; Discovery, Natural Occurence; Nuclear Data; Preparation, Handling, Radiation Risk; Physico-chemical Properties; Astatine Compounds and Chemical Reactions; Biological Effects and Applications. Entries are sorted alphabetically by authors name in each chapter, and cross-references to other chapters are provided if appropriate. (R.P.)

  2. Astatine-211: production and availability.

    Science.gov (United States)

    Zalutsky, Michael R; Pruszynski, Marek

    2011-07-01

    The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211 can be produced in reasonable yield from natural bismuth targets via the (209)Bi(α,2n)(211)At nuclear reaction utilizing straightforward methods. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of (210)At, which is problematic because of its 138.4-day half life α-particle emitting daughter, (210)Po. The intrinsic cost for producing (211)At is reasonably modest and comparable to that of commercially available (123)I. The major impediment to (211)At availability is attributed to the need for a medium energy α-particle beam for its production. On the other hand, there are about 30 cyclotrons in the world that have the beam characteristics required for (211)At production. PMID:22201707

  3. Adsorption interaction of astatine species with quartz and gold surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Serov, A. [Paul Scherrer Institute, Villigen (Switzerland). Lab. for Radiochemistry and Environmental Chemistry; Bern Univ. (Switzerland). Dept. for Chemistry and Biochemistry; Aksenov, N.; Bozhikov, G. [Joint Institute for Nuclear Research, Dubna (RU). Flerov Lab. of Nuclear Reactions] (and others)

    2011-07-01

    The adsorption interaction of various astatine species with quartz and gold surfaces was investigated by gas chromatography methods. Due to variations of the redox potential of the carrier gas elemental astatine, astatine oxide and hypo-astatic acid have been produced. The identification of the astatine compounds is based on the analogy assumption to the gas phase chemistry of the closest homologues in group 17 of the periodic table, iodine and bromine. The deposition temperatures as well as enthalpies of adsorption have been determined for the astatine species. The enhancement of the metallic character within group 17 towards higher Z is clearly confirmed. Macroscopic properties (sublimation enthalpy) of previously unstudied AtO{sub 2} and HAtO were estimated. The determined data for elemental astatine were compared to available literature data. Based on the obtained experimental results possible designs of experiments for studying of chemical properties of the recently discovered element 117 can be suggested. (orig.)

  4. Recent advances in the organic chemistry of astatine

    International Nuclear Information System (INIS)

    Investigation on the chemical behaviour of astatine in the last decade are surveyed. The survey covers the physical and chemical properties of astatine, synthesis and identification of organic astatine compounds, their physicochemical properties. A special chapter is devoted to biomedical applications, including inorganic 211At species, 211At-labelled proteins and drugs. An extensive bibliography of the related literature is given. (N.T.) 129 refs.; 12 figs.; 14 tabs

  5. 219-S chemical compatibility

    Energy Technology Data Exchange (ETDEWEB)

    GOODWIN, L.D.

    1999-08-31

    This document consists of tables of the materials that make up the ''wetted'' parts of the 219-S waste handling facility and a combination of manufacturer lists of chemicals that are not recommended.

  6. Discovery of the astatine, radon, francium, and radium isotopes

    CERN Document Server

    Fry, C

    2012-01-01

    Currently, thirty-nine astatine, thirty-nine radon, thirty-five francium, and thirty-four radium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  7. Extraction of astatine isotopes for development of radiopharmaceuticals using a 211Rn-211At generator

    International Nuclear Information System (INIS)

    In order to utilize a 211At isotope, a promising α-emitter for radionuclide therapy, the chemical properties of astatine isotopes are studied. We have examined wet chemistry methods through the distribution ratios of astatine in liquid-liquid extraction. The astatine isotopes have been found to be well extracted into DIPE and MIBK. We observed that the distribution ratio of astatine isotopes increases with concentrations of HCl greater than 3 M, while it decreases with the HCl concentration less than 2 M. The results will be useful for development of the 211Rn-211At generator. (author)

  8. Astatine-211-Labeled Targeted Radiotherapeutics: An Update

    International Nuclear Information System (INIS)

    The heavy halogen 211At was first proposed for use in α-particle targeted radiotherapy more than 30 years ago and continues to be one of the most promising radionuclides for this purpose. Although its 7.2-h half life is not ideal for intravenously administered whole antibodies, it is compatible with the pharmacokinetics of antibody fragments, peptides, aptamers and organic molecules. Its diverse chemistry allows its incorporation into a wide array of targeting vehicles, relying on its chemical similarity to iodine to provide a useful point of departure. On the other hand, the relatively low carbon-astatine bond strength is challenging. In common with the other α-emitters being discussed at this symposium, lack of reliable availability is one of the biggest hurdles in the use of 211At for targeted radiotherapy. However, in the case of 211At, it is not a question of production cost or availability of target material, because 211At can be produced in reasonable yield from natural bismuth targets. Rather, the difficulty is the lack of cyclotrons equipped with the medium energy α-particle beams required for its production. If the infrastructure for producing 211At is to be improved to the stage where 211At-labeled radiopharmaceuticals can have a meaningful impact, several developments must occur. First, the ability to produce clinically relevant levels of 211At that can be shipped to remote locations in chemically tractable form must be demonstrated. Approaches under consideration include compensating for radiolysis-mediated effects and the consideration of alternative chemistries. Second, strategies for compensating for heterogeneities in dose deposition must be developed, hopefully in a way that is compatible with approval for human use. And third, it is essential that more clinical trials be performed with 211At-labeled therapeutics, particularly in settings of minimum residual disease where the radiobiological advantages of α-particles can be best exploited. Our

  9. Comment: 219 [Taxonomy Icon

    Lifescience Database Archive (English)

    Full Text Available Japanese medaka Oryzias latipes Oryzias_latipes_L.png 219.png Taxonomy icon (c) Database Center for Life Sci...ence licensed under CC Attribution2.1 Japan アイコン:メダカ HNI-Ⅱ系統バージョン bando 2010/02/15 15:31:07 2010/02/16 09:53:27 ...

  10. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    CERN Document Server

    Rothe, S; Antalic, S; Borschevsky, A; Capponi, L; Cocolios, T E; De Witte, H; Eliav, E; Fedorov, D V; Fedosseev, V N; Fink, D A; Fritzsche, S; Ghys, L; Huyse, M; Imai, N; Kaldor, U; Kudryavtsev, Yu; Köster, U; Lane, J; Lassen, J; Liberati, V; Lynch, K M; Marsh, B A; Nishio, K; Pauwels, D; Pershina, V; Popescu, L; Procter, T J; Radulov, D; Raeder, S; Rajabali, M M; Rapisarda, E; Rossel, R E; Sandhu, K; Seliverstov, M D; Sjödin, A M; Van den Bergh, P; Van Duppen, P; Venhart, M; Wakabayashi, Y; Wendt K D A

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of smallest quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.317510(8) eV. New ab initio calculations were performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of super-heavy element 117, the heaviest homologue of astatine.

  11. Synthesis and Evaluation of Astatinated N-[2-(Maleimido)ethyl]-3-(trimethylstannyl)benzamide Immunoconjugates.

    Science.gov (United States)

    Aneheim, Emma; Gustafsson, Anna; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Svedhem, Sofia; Lindegren, Sture

    2016-03-16

    Effective treatment of metastasis is a great challenge in the treatment of different types of cancers. Targeted alpha therapy utilizes the short tissue range (50-100 μm) of α particles, making the method suitable for treatment of disseminated occult cancers in the form of microtumors or even single cancer cells. A promising radioactive nuclide for this type of therapy is astatine-211. Astatine-211 attached to tumor-specific antibodies as carrier molecules is a system currently under investigation for use in targeted alpha therapy. In the common radiolabeling procedure, astatine is coupled to the antibody arbitrarily on lysine residues. By instead coupling astatine to disulfide bridges in the antibody structure, the immunoreactivity of the antibody conjugates could possibly be increased. Here, the disulfide-based conjugation was performed using a new coupling reagent, maleimidoethyl 3-(trimethylstannyl)benzamide (MSB), and evaluated for chemical stability in vitro. The immunoconjugates were subsequently astatinated, resulting in both high radiochemical yield and high specific activity. The MSB-conjugate was shown to be stable with a long shelf life prior to the astatination. In a comparison of the in vivo distribution of the new immunoconjugate with other tin-based immunoconjugates in tumor-bearing mice, the MSB conjugation method was found to be a viable option for successful astatine labeling of different monoclonal antibodies. PMID:26791409

  12. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    OpenAIRE

    Rothe, S.; A. N. Andreyev; Antalic, S; Borschevsky, A.; Capponi, L.; Cocolios, T.E.; Witte, H.; Eliav, E.; Fedorov, D. V.; Fedosseev, V. N.; Fink, D. A.; Fritzsche, S.; Ghys, L.; Huyse, M.; Imai, N.

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the io...

  13. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    DEFF Research Database (Denmark)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom;

    2015-01-01

    To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical...... and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitted α-particles, this therapy is particularly suited to treating occult, disseminated cancers. Astatine is not intrinsically tumour-specific; therefore, it requires an appropriate tumour-specific targeting...... vector, which can guide the radiation to the cancer cells. Consequently, an appropriate method is required for coupling the nuclide to the vector. To increase the availability of astatine-211 radiopharmaceuticals for targeted alpha therapy, their production should be automated. Here, we present a method...

  14. Study of Astatine (III) reactions with O, S and N ligands in solution

    International Nuclear Information System (INIS)

    Full text of publication follows. Astatine (At, Z=85: [Xe]4f145d106s26p5) belongs to the halogen group and is located below iodine in the periodic table. One of its isotopes (211At) appears promising as a therapeutic agent in nuclear medicine (Ref.1) owing to the energy of the alpha particles emitted during the disintegration of its nucleus and its short physical half-life (7.2 h). Since there are no stable isotopes of astatine, the chemistry of this element remains poorly understood. Generally, At is supposed to behave as a halogen (Ref.2) but it has been shown recently in our group that astatine presents a metallic behaviour in aqueous solution: it notably exists as At+ and AtO+ species under the oxidation states +I and +III (Ref.3). At the present time, the number of studies dealing with the complexation properties of the cationic forms of astatine remains limited (Ref.4), owing to its low availability. In this work, we have investigated the reactions of AtO+ species with different hetero-atomic (N, S, O) model ligands. A combined approach based on experimental and theoretical studies has been used (Ref.5). On account of the difficulties of experimental investigations of astatine species, the reactivity of AtO+ was explored using a competition method founded on astatine distributions between two distinct phases. Furthermore, for each AtO+/ ligand complex, the nature of the species formed and the associated thermodynamic constants were determined by computational modeling (DFT calculations). In this framework, an original computational methodology was developed to take into account the specificities of astatine, notably the associated relativistic effects. The computed equilibrium constants have been confronted with the experimental results. This comparison demonstrates an outstanding coherence between experience and theory. Furthermore, the analysis of the results shows a key role of solvent effects on astatine chemistry. Lastly, a specific reactivity for the

  15. 12 CFR 741.219 - Investment requirements.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Investment requirements. 741.219 Section 741.219 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS... Unions That Also Apply to Federally Insured State-Chartered Credit Unions § 741.219...

  16. 33 CFR 117.219 - Pequonnock River.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Pequonnock River. 117.219 Section 117.219 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Connecticut § 117.219 Pequonnock River. (a)...

  17. 49 CFR 219.104 - Responsive action.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Responsive action. 219.104 Section 219.104..., DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Prohibitions § 219.104 Responsive action. (a... (e) of this section apply. (3)(i) This section does not apply to actions based on breath or...

  18. 22 CFR 219.160 - Communications.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Communications. 219.160 Section 219.160 Foreign... DEVELOPMENT § 219.160 Communications. (a) The agency shall take appropriate steps to ensure effective communication with applicants, participants, personnel of other Federal entities, and members of the public....

  19. 32 CFR 219.114 - Cooperative research.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Cooperative research. 219.114 Section 219.114...) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.114 Cooperative research. Cooperative research projects are... cooperative research projects, each institution is responsible for safeguarding the rights and welfare...

  20. 49 CFR 219.17 - Construction.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Construction. 219.17 Section 219.17 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE General § 219.17 Construction. Nothing in this part— (a)...

  1. Some aspects of the organic, biological and inorganic chemistry of astatine

    International Nuclear Information System (INIS)

    Astatine has no stable isotopes and the radioactive isotopes with half-lives sufficiently long for chemical experiments (209At, 210At, 211At) must be produced artificially with a cyclotron or with a high energy accelerator by spallation of Th. This thesis deals with the synthesis and chemistry of At-compounds and the determination of some of their properties. (C.F.)

  2. Astatine-211 Pathway from Radiochemistry to Clinical Investigation

    International Nuclear Information System (INIS)

    Particularly in clinical settings where tumour burden is low and cancers are located in close proximity to essential normal tissue structures, α-particle emitting radionuclides can offer significant advantages for targeted radionuclide therapy. One of the first alpha emitters to be evaluated for this purpose is the 7.2-h half-life radiohalogen Astatine-211 (211At). From a commercialization-potential perspective 211At, is less appealing than the longer half-life alpha particle emitters Radium-223, Actinium-225 and Thorium-227, which have become the focus of many laboratories. However, if methods for providing a better supply of 211At could be developed, this alpha emitter would be the radionuclide of choice for many potential therapeutic applications. With regard to the production of 211At, this can be readily be accomplished by bombarding natural bismuth targets with 28−29.5 MeV alpha particles via the 209Bi(α,2n)211At reaction. The goal is to utilize an alpha particle beam energy that provides the required balance for maximizing 211At production while minimizing creation of 210At, which is problematic because of its 138.4-day half life alpha-particle emitting daughter, 210Po. For most intended clinical applications, alpha particle beam energy of about 29 MeV offers the best compromise between maximizing yield and providing 211At with sufficient radionuclidic purity for clinical use. Clinically relevant levels of 211At have been produced at several institutions using both internal and external cyclotron targets

  3. 36 CFR 219.30 - Plan documentation.

    Science.gov (United States)

    2010-07-01

    ... Section 219.30 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PLANNING National Forest System Land and Resource Management Planning Planning Documentation § 219.30 Plan... other information relevant to how the plan area is to be managed. Planning documents should be...

  4. 48 CFR 219.808 - Contract negotiations.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract negotiations. 219..., DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (The 8(a) Program) 219.808 Contract negotiations....

  5. 48 CFR 219.708 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... OF DEFENSE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS The Small Business Subcontracting Program 219.708 Contract clauses. (b)(1)(A) Use the clause at 252.219-7003, Small Business Subcontracting Plan... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clauses....

  6. 28 CFR 2.19 - Information considered.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Information considered. 2.19 Section 2.19 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND RECOMMITMENT OF PRISONERS..., no recommendation (including a prosecutorial recommendation pursuant to a plea agreement) may...

  7. 36 CFR 219.19 - Ecological, social, and economic sustainability.

    Science.gov (United States)

    2010-07-01

    ... economic sustainability. 219.19 Section 219.19 Parks, Forests, and Public Property FOREST SERVICE..., Social, and Economic Sustainability § 219.19 Ecological, social, and economic sustainability. Sustainability, composed of interdependent ecological, social, and economic elements, embodies the...

  8. An attempt to explore the production routes of Astatine radionuclides: Theoretical approach

    OpenAIRE

    Maiti, Moumita; Lahiri, Susanta

    2008-01-01

    In order to fulfil the recent thrust of Astatine radionuclides in the field of nuclear medicine various production routes have been explored in the present work. The possible production routes of $^{209-211}$At comprise both light and heavy ion induced reactions at the bombarding energy range starting from threshold to maximum 100 MeV energy. For this purpose, we have used the nuclear reaction model codes TALYS, ALICE91 and PACE-II. Excitation functions of those radionuclides, produced throug...

  9. 36 CFR 219.10 - Site-specific decisions.

    Science.gov (United States)

    2010-07-01

    ... PLANNING National Forest System Land and Resource Management Planning The Framework for Planning § 219.10... consistent with §§ 219.12 through 219.18, follow the planning framework described in §§ 219.4 through...

  10. Dicty_cDB: CHR219 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CH (Link to library) CHR219 (Link to dictyBase) - - - Contig-U16511-1 CHR219P (Link to Original site) CHR...219F 609 CHR219Z 786 CHR219P 1375 - - Show CHR219 Library CH (Link to library) Clone ID CHR...e URL http://dictycdb.biol.tsukuba.ac.jp/CSM/CH/CHR2-A/CHR219Q.Seq.d/ Representative seq. ID CHR...219P (Link to Original site) Representative DNA sequence >CHR219 (CHR219Q) /CSM/CH/CHR2-A/CHR...ky**firs*ywswfkw**srrc*kprfirqircf*tsigsrrn*kprfgrscf*nhf*ir trsyssn*wsts*lyc*srnscss*inr*kcl*cllkhrtnittitt

  11. 49 CFR 571.219 - Standard No. 219; Windshield zone intrusion.

    Science.gov (United States)

    2010-10-01

    ... Federal Motor Vehicle Safety Standards § 571.219 Standard No. 219; Windshield zone intrusion. S1. Scope.... S3. Application. This standard applies to passenger cars and to multipurpose passenger vehicles... removable windshields. S4. Definitions. Daylight Opening (DLO) means the maximum unobstructed...

  12. Determination of the electron affinity of astatine and polonium by laser photodetachment

    CERN Multimedia

    We propose to conduct the first electron anity (EA) measurements of the two elements astatine (At) and polonium (Po). Collinear photodetachment spectroscopy will allow us to measure these quantities with an uncertainty limited only by the spectral linewidth of the laser. We plan to use negative ion beams of the two radioactive elements At and Po, which are only accessible on-line and at ISOLDE. The feasibility of our proposed method and the functionality of the experimental setup have been demonstrated at ISOLDE in o-line tests by the clear observation of the photodetachment threshold for stable iodine. This proposal is based on our Letter of Intent I-148 [1].

  13. Radiological risk of actinon (/sup 219/Rn)

    Energy Technology Data Exchange (ETDEWEB)

    Crawford, D.J.

    1981-12-01

    The research reported was designed to provide information on the following subjects: (1) development of the functional relations between exposure to the /sup 219/Rn decay chain and pertinent health effects; (2) specification of the circumstances under which a significant concentration of the decay chain may occur; (3) recommendation of an exposure standard which will provide protection of the public from significant elevation of health effects; and (4) an assessment of the impact of /sup 219/Rn on determinations of the concentration of the /sup 222/Rn decay chain and/or its precursors.

  14. Radiological risk of actinon (219Rn)

    International Nuclear Information System (INIS)

    The research reported was designed to provide information on the following subjects: (1) development of the functional relations between exposure to the 219Rn decay chain and pertinent health effects; (2) specification of the circumstances under which a significant concentration of the decay chain may occur; (3) recommendation of an exposure standard which will provide protection of the public from significant elevation of health effects; and (4) an assessment of the impact of 219Rn on determinations of the concentration of the 222Rn decay chain and/or its precursors

  15. 36 CFR 219.3 - Overview.

    Science.gov (United States)

    2010-07-01

    ... Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PLANNING National Forest System Land and Resource Management Planning The Framework for Planning § 219.3 Overview. (a) The planning framework. Land and resource management planning is a flexible process for fitting solutions...

  16. 36 CFR 219.9 - Revision.

    Science.gov (United States)

    2010-07-01

    ... Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PLANNING National Forest System Land and Resource Management Planning The Framework for Planning § 219.9 Revision. (a) Application... is a review of the overall management of a unit of the National Forest System and an opportunity...

  17. 36 CFR 219.2 - Principles.

    Science.gov (United States)

    2010-07-01

    ... Forest System Land and Resource Management Planning Purpose and Principles § 219.2 Principles. The... planning to guide management of the National Forest System is to maintain or restore ecological... American people in the management of the national forests and grasslands. (e) Planning is an...

  18. 49 CFR 219.23 - Railroad policies.

    Science.gov (United States)

    2010-10-01

    ... .02 or greater but less than .04. (12) Information concerning the effects of alcohol misuse on an..., DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE General § 219.23 Railroad policies. (a) Whenever a breath or body fluid test is required of an employee under this part, the railroad must...

  19. 36 CFR 219.20 - Ecological sustainability.

    Science.gov (United States)

    2010-07-01

    ... under 50 CFR part 402. The plan decision documents must provide a rationale for adoption or rejection of... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Ecological sustainability... Sustainability § 219.20 Ecological sustainability. To achieve ecological sustainability, the responsible...

  20. 32 CFR 219.107 - IRB membership.

    Science.gov (United States)

    2010-07-01

    ... PROTECTION OF HUMAN SUBJECTS § 219.107 IRB membership. (a) Each IRB shall have at least five members, with... members, and the diversity of the members, including consideration of race, gender, and cultural... counsel in safeguarding the rights and welfare of human subjects. In addition to possessing...

  1. 49 CFR 219.301 - Testing for reasonable cause.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Testing for reasonable cause. 219.301 Section 219... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Testing for Cause § 219.301 Testing for reasonable cause. (a) Authorization. A railroad may, under the conditions specified in...

  2. 48 CFR 219.804 - Evaluation, offering, and acceptance.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Evaluation, offering, and acceptance. 219.804 Section 219.804 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... Business Administration (The 8(a) Program) 219.804 Evaluation, offering, and acceptance. When...

  3. 48 CFR 219.811-3 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clauses. 219.811..., DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (The 8(a) Program) 219.811-3 Contract clauses. (1) Use the clause at 252.219-7009, Section...

  4. 48 CFR 219.505 - Rejecting Small Business Administration recommendations.

    Science.gov (United States)

    2010-10-01

    ...-Asides for Small Business 219.505 Rejecting Small Business Administration recommendations. (b) The... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Rejecting Small Business Administration recommendations. 219.505 Section 219.505 Federal Acquisition Regulations System...

  5. 48 CFR 219.705-4 - Reviewing the subcontracting plan.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Reviewing the subcontracting plan. 219.705-4 Section 219.705-4 Federal Acquisition Regulations System DEFENSE ACQUISITION... Subcontracting Program 219.705-4 Reviewing the subcontracting plan. (d) Challenge any subcontracting plan...

  6. 20 CFR 219.23 - Evidence to prove death.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Evidence to prove death. 219.23 Section 219... EVIDENCE REQUIRED FOR PAYMENT Evidence of Age and Death § 219.23 Evidence to prove death. (a) Preferred evidence of death. The best evidence of a person's death is— (1) A certified copy of or extract from...

  7. 30 CFR 219.102 - Method of payment.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Method of payment. 219.102 Section 219.102... (EFT). Should a State prefer to receive its payment by EFT, it should request this payment method in... DISTRIBUTION AND DISBURSEMENT OF ROYALTIES, RENTALS, AND BONUSES Oil and Gas, Onshore § 219.102 Method...

  8. 29 CFR 825.219 - Rights of a key employee.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Rights of a key employee. 825.219 Section 825.219 Labor....219 Rights of a key employee. (a) An employer who believes that reinstatement may be denied to a key... recover its cost of health benefit premiums. A key employee's rights under FMLA continue unless and...

  9. 40 CFR 86.219-94 - CVS calibration.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false CVS calibration. 86.219-94 Section 86.219-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... Later Model Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New...

  10. 49 CFR 219.105 - Railroad's duty to prevent violations.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Railroad's duty to prevent violations. 219.105 Section 219.105 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD... duty to prevent violations. (a) A railroad may not, with actual knowledge, permit an employee to go...

  11. 49 CFR 1542.219 - Supplementing law enforcement personnel.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Supplementing law enforcement personnel. 1542.219... Operations § 1542.219 Supplementing law enforcement personnel. (a) When TSA decides, after being notified by... private law enforcement personnel are available to carry out the requirements of § 1542.215, TSA...

  12. 49 CFR 219.11 - General conditions for chemical tests.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false General conditions for chemical tests. 219.11 Section 219.11 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD... for chemical tests. (a) Any employee who performs covered service for a railroad is deemed to...

  13. 14 CFR 21.9 - Replacement and modification articles.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Replacement and modification articles. 21.9... CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS General § 21.9 Replacement and modification articles. (a) If a person knows, or should know, that a replacement or modification article is reasonably likely to...

  14. 49 CFR 1544.219 - Carriage of accessible weapons.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Carriage of accessible weapons. 1544.219 Section...: AIR CARRIERS AND COMMERCIAL OPERATORS Operations § 1544.219 Carriage of accessible weapons. (a... weapons, do not apply to a law enforcement officer (LEO) aboard a flight for which screening is...

  15. 20 CFR 219.24 - Evidence of presumed death.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Evidence of presumed death. 219.24 Section... EVIDENCE REQUIRED FOR PAYMENT Evidence of Age and Death § 219.24 Evidence of presumed death. When a person cannot be proven dead but evidence of death is needed, the Board may presume he or she died at a...

  16. 48 CFR 1852.219-73 - Small business subcontracting plan.

    Science.gov (United States)

    2010-10-01

    ... Provisions and Clauses 1852.219-73 Small business subcontracting plan. As prescribed in 1819.708-70(a), insert the following provision: Small Business Subcontracting Plan (MAY 1999) (a) This provision is not... contain FAR clause 52.219-9, “Small Business Subcontracting Plan.” The apparent low bidder must submit...

  17. 49 CFR 219.211 - Analysis and follow-up.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Analysis and follow-up. 219.211 Section 219.211 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Analysis and follow-up. (a) The laboratory designated in appendix B to this part undertakes prompt...

  18. Unexpected Behavior of the Heaviest Halogen Astatine in the Nucleophilic Substitution of Aryliodonium Salts.

    Science.gov (United States)

    Guérard, François; Lee, Yong-Sok; Baidoo, Kwamena; Gestin, Jean-François; Brechbiel, Martin W

    2016-08-22

    Aryliodonium salts have become precursors of choice for the synthesis of (18) F-labeled tracers for nuclear imaging. However, little is known on the reactivity of these compounds with heavy halides, that is, radioiodide and astatide, at the radiotracer scale. In the first comparative study of radiohalogenation of aryliodonium salts with (125) I(-) and (211) At(-) , initial experiments on a model compound highlight the higher reactivity of astatide compared to iodide, which could not be anticipated from the trends previously observed within the halogen series. Kinetic studies indicate a significant difference in activation energy (Ea =23.5 and 17.1 kcal mol(-1) with (125) I(-) and (211) At(-) , respectively). Quantum chemical calculations suggest that astatination occurs via the monomeric form of an iodonium complex whereas iodination occurs via a heterodimeric iodonium intermediate. The good to excellent regioselectivity of halogenation and high yields achieved with diversely substituted aryliodonium salts indicate that this class of compounds is a promising alternative to the stannane chemistry currently used for heavy radiohalogen labeling of tracers in nuclear medicine. PMID:27305065

  19. Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

    CERN Document Server

    Andreyev, Andrei

    2013-01-01

    Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

  20. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

    Energy Technology Data Exchange (ETDEWEB)

    MICHAEL R. ZALUTSKY

    2012-08-08

    Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

  1. 49 CFR 219.302 - Prompt specimen collection; time limitation.

    Science.gov (United States)

    2010-10-01

    ... or drug testing under this section after the expiration of an eight-hour period from— (1) The time of... period. (f) (g) Section 219.23 prescribes the notice to an employee that is required to provide breath...

  2. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    Energy Technology Data Exchange (ETDEWEB)

    Rothe, Sebastian

    2012-09-24

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  3. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    International Nuclear Information System (INIS)

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  4. Radiobiological Effects of Alpha-Particles from Astatine-211: From DNA Damage to Cell Death

    Energy Technology Data Exchange (ETDEWEB)

    Claesson, Kristina

    2011-05-15

    In recent years, the use of high linear energy transfer (LET) radiation for radiotherapeutic applications has gained increased interest. Astatine-211 (211At) is an alpha-particle emitting radionuclide, promising for targeted radioimmunotherapy of isolated tumor cells and microscopic clusters. To improve development of safe radiotherapy using 211At it is important to increase our knowledge of the radiobiological effects in cells. During radiotherapy, both tumors and adjacent normal tissue will be irradiated and therefore, it is of importance to understand differences in the radio response between proliferating and resting cells. The aim of this thesis was to investigate effects in fibroblasts with different proliferation status after irradiation with alpha-particles from 211At or X-rays, from inflicted DNA damage, to cellular responses and biological consequences. Throughout this work, irradiation was performed with alpha-particles from 211A or X-rays. The induction and repair of double-strand breaks (DSBs) in human normal fibroblasts were investigated using pulsed-field gel electrophoresis and fragment analysis. The relative biological effectiveness (RBE) of 211At for DSB induction varied between 1.4 and 3.1. A small increase of DSBs was observed in cycling cells compared to stationary cells. The repair kinetics was slower after 211At and more residual damage was found after 24 h. Comparison between cells with different proliferation status showed that the repair was inefficient in cycling cells with more residual damage, regardless of radiation quality. Activation of cell cycle arrests was investigated using immunofluorescent labeling of the checkpoint kinase Chk2 and by measuring cell cycle distributions with flow cytometry analysis. After alpha-particle irradiation, the average number of Chk2-foci was larger and the cells had a more affected cell cycle progression for several weeks compared with X-irradiated cells, indicating a more powerful arrest after 211At

  5. 50 CFR 300.219 - Vessel monitoring system.

    Science.gov (United States)

    2010-10-01

    ... system. (a) SAC and VMS Helpdesk contact information and business hours. The contact information for the..., Hawaii Standard Time. The contact information for the NOAA Office of Law Enforcement's VMS Helpdesk for the purpose of this section is: telephone: (888) 219-9228; e-mail: ole.helpdesk@noaa.gov. The...

  6. 9 CFR 93.219 - Declaration for poultry.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Declaration for poultry. 93.219... AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS IMPORTATION OF CERTAIN ANIMALS, BIRDS, FISH, AND POULTRY, AND CERTAIN ANIMAL, BIRD, AND POULTRY PRODUCTS;...

  7. 48 CFR 52.219-10 - Incentive Subcontracting Program.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Incentive Subcontracting....219-10 Incentive Subcontracting Program. As prescribed in 19.708(c)(1), insert the following clause: Incentive Subcontracting Program (OCT 2001) (a) Of the total dollars it plans to spend under...

  8. 36 CFR 219.5 - Information development and interpretation.

    Science.gov (United States)

    2010-07-01

    ... PLANNING National Forest System Land and Resource Management Planning The Framework for Planning § 219.5...) Station Directors and Regional Foresters must have joint responsibility for Forest Service participation... assessments provide information regarding ecological, economic, or social issues that are broad in...

  9. 26 CFR 1.219-2 - Definition of active participant.

    Science.gov (United States)

    2010-04-01

    ... age is not an active participant by reason of his participation in that plan. (c) Money purchase plan... 26 Internal Revenue 3 2010-04-01 2010-04-01 false Definition of active participant. 1.219-2... active participant. (a) In general. This section defines the term active participant for individuals...

  10. 36 CFR 219.11 - Monitoring and evaluation for adaptive management.

    Science.gov (United States)

    2010-07-01

    ... adaptive management. 219.11 Section 219.11 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PLANNING National Forest System Land and Resource Management Planning The Framework for Planning § 219.11 Monitoring and evaluation for adaptive management. (a) Plan monitoring...

  11. 36 CFR 219.22 - The overall role of science in planning.

    Science.gov (United States)

    2010-07-01

    ... in planning. 219.22 Section 219.22 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PLANNING National Forest System Land and Resource Management Planning The Contribution of Science § 219.22 The overall role of science in planning. (a) The responsible official must ensure that the...

  12. 36 CFR 219.31 - Maintenance of the plan and planning records.

    Science.gov (United States)

    2010-07-01

    ... planning records. 219.31 Section 219.31 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PLANNING National Forest System Land and Resource Management Planning Planning Documentation § 219.31 Maintenance of the plan and planning records. (a) Each National Forest or Grassland...

  13. 76 FR 50810 - Seventh Meeting: RTCA Special Committee 219: Attitude and Heading Reference System

    Science.gov (United States)

    2011-08-16

    ... Committee 219 meeting: Attitude and Heading Reference System. SUMMARY: The FAA is issuing this notice to advise the public of a meeting of RTCA Special Committee 219: Attitude and Heading Reference System... Federal Aviation Administration Seventh Meeting: RTCA Special Committee 219: Attitude and...

  14. 75 FR 49550 - Fifth Meeting: RTCA Special Committee 219: Attitude and Heading Reference System (AHRS)

    Science.gov (United States)

    2010-08-13

    ...: Notice of RTCA Special Committee 219: Attitude and Heading Reference System (AHRS). SUMMARY: The FAA is issuing this notice to advise the public of a meeting of ] RTCA Special Committee 219: Attitude and... Federal Aviation Administration Fifth Meeting: RTCA Special Committee 219: Attitude and Heading...

  15. 48 CFR 1852.219-83 - Limitation of the principal investigator-SBIR program.

    Science.gov (United States)

    2010-10-01

    ... investigator-SBIR program. 1852.219-83 Section 1852.219-83 Federal Acquisition Regulations System NATIONAL... Provisions and Clauses 1852.219-83 Limitation of the principal investigator—SBIR program. As prescribed in 1819.7302(d), insert the following clause: Limitation of the Principal Investigator—SBIR Program...

  16. 48 CFR 1852.219-84 - Limitation of the principal investigator-STTR program.

    Science.gov (United States)

    2010-10-01

    ... investigator-STTR program. 1852.219-84 Section 1852.219-84 Federal Acquisition Regulations System NATIONAL... Provisions and Clauses 1852.219-84 Limitation of the principal investigator—STTR program. As prescribed in 1819.7302(e), insert the following clause: Limitation of the Principal Investigator—STTR Program...

  17. 48 CFR 1552.219-74 - Small disadvantaged business participation evaluation factor.

    Science.gov (United States)

    2010-10-01

    ... business participation evaluation factor. 1552.219-74 Section 1552.219-74 Federal Acquisition Regulations... Texts of Provisions and Clauses 1552.219-74 Small disadvantaged business participation evaluation factor. As prescribed in 1519.204(c), insert the following clause: Small Disadvantaged Business...

  18. 40 CFR 80.219 - Designation and downstream requirements for GPA gasoline.

    Science.gov (United States)

    2010-07-01

    ... requirements for GPA gasoline. 80.219 Section 80.219 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY...-in Program § 80.219 Designation and downstream requirements for GPA gasoline. The requirements and... standards under § 80.216 as “GPA” gasoline. (b) Product transfer documents. (1) On each occasion that...

  19. 36 CFR 219.12 - Collaboration and cooperatively developed landscape goals.

    Science.gov (United States)

    2010-07-01

    ... cooperatively developed landscape goals. 219.12 Section 219.12 Parks, Forests, and Public Property FOREST... Collaborative Planning for Sustainability § 219.12 Collaboration and cooperatively developed landscape goals. (a... process. (b) Cooperatively developed landscape goals. (1) The responsible official and other...

  20. 48 CFR 52.219-7 - Notice of Partial Small Business Set-Aside.

    Science.gov (United States)

    2010-10-01

    ... the acquisition is for a product in a class for which the Small Business Administration has determined... Business Set-Aside. 52.219-7 Section 52.219-7 Federal Acquisition Regulations System FEDERAL ACQUISITION... Clauses 52.219-7 Notice of Partial Small Business Set-Aside. As prescribed in 19.508(d), insert...

  1. 48 CFR 52.219-6 - Notice of Total Small Business Set-Aside.

    Science.gov (United States)

    2010-10-01

    ... is for a product in a class for which the Small Business Administration has determined that there are... Business Set-Aside. 52.219-6 Section 52.219-6 Federal Acquisition Regulations System FEDERAL ACQUISITION... Clauses 52.219-6 Notice of Total Small Business Set-Aside. As prescribed in 19.508(c), insert...

  2. 49 CFR 219.611 - Test result indicating prohibited alcohol concentration; procedures.

    Science.gov (United States)

    2010-10-01

    ... concentration; procedures. 219.611 Section 219.611 Transportation Other Regulations Relating to Transportation... concentration; procedures. Procedures for administrative handling by the railroad in the event an employee's confirmation test indicates an alcohol concentration of .04 or greater are set forth in § 219.104....

  3. 26 CFR 2.1-9 - Valuation of securities in fund.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 14 2010-04-01 2010-04-01 false Valuation of securities in fund. 2.1-9 Section 2.1-9 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) MARITIME CONSTRUCTION RESERVE FUND § 2.1-9 Valuation of securities in fund. (a) Equivalent...

  4. 48 CFR 752.219-8 - Utilization of small business concerns and small disadvantaged business concerns.

    Science.gov (United States)

    2010-10-01

    ... business concerns and small disadvantaged business concerns. 752.219-8 Section 752.219-8 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions and Clauses 752.219-8 Utilization of small business...

  5. Anesthetic and surgical complications in 219 cases of myotonic dystrophy.

    Science.gov (United States)

    Mathieu, J; Allard, P; Gobeil, G; Girard, M; De Braekeleer, M; Bégin, P

    1997-12-01

    The objective of this study was to assess the frequency, type, and severity of perioperative complications after a first surgery under general anesthesia in patients with myotonic dystrophy (DM) and to measure the association with suspected risk factors. Numerous cases of perioperative complications in DM patients have been reported. Hazards have been associated with the use of thiopentone, suxamethonium, neostigmine, and halothane. A retrospective study of perioperative complications was conducted for 219 DM patients who had their first surgery under general anesthesia at the Chicoutimi Hospital. The overall frequency of complications was 8.2% (18 of 219). Most complications (16 of 18) were pulmonary, including five patients with acute ventilatory failure necessitating ventilatory support, four patients with atelectasis, and three patients with pneumonia. Using multivariate analysis, we found that the risk of perioperative pulmonary complications (PPC) was significantly higher after an upper abdominal surgery (odds ratio (OR), 24.4; 95% CI, 4.0 to 149.3) and for patients with a severe muscular disability, as assessed by the presence of proximal limb weakness (OR, 14.1; 95% CI, 1.5 to 134.4). The likelihood of PPC was not related to any specific anesthetic drug. Because of the increased risk of PPC, careful monitoring during the early postoperative period, protection of upper airways, chest physiotherapy, and incentive spirometry are mandatory in all symptomatic DM patients, particularly those with a severe muscular disability or those who have undergone an upper abdominal surgery.

  6. Antivirus effects of extract Jn219 in experimental models of rotavirus infection%Jn219抗轮状病毒的实验研究

    Institute of Scientific and Technical Information of China (English)

    高华英; 司书毅; 李妍; 李鹏; 孟红

    2008-01-01

    目的 探讨真菌提取物Jn219在体内、外抗轮状病毒的作用.方法 利用含有Jn219的提取物,通过轮状病毒(RV)-MA104体外细胞感染模型,研究Jn219体外抗RV的作用;采用RV-乳鼠感染模型和疗效模型,以病理学、免疫组化技术探讨Jn219体内抑制病毒增殖、保护肠黏膜的作用.结果 Jn219在体外表现抑制RV SA11在MA104细胞增殖的作用,其半数抑毒浓度为1:384.92,抑毒指数为76.92;Jn219在体内抑制了病毒的复制,缓解了RV SA11感染引起的乳鼠腹泻,降低了乳鼠病死率,减轻了RV感染引起的肠道病理性变化.结论 Jn219在体外、体内均有抑制RV复制的作用.%Objective To observe the antivirus effects of extract Jn219 from epiphyte on rotavirus in vitro and in vivo. Methods Using a model of rotavirus(RV)-MA104, we tested the antiviral activity of Jn219 in vitro. Furthermore, effects of inhibiting RV duplication and protecting mucous membrane were studied by using pathological and immunohisto-chemical techniques in neonatal mice models of infection and therapy. Results Jn219 inhibited RV duplication and at-tenuated the cytopathogenic effect of RV SA11-infected MA104. The IC50 is 1 : 384.92. TI: ED50/IC50 = 76.92. Further more, Jn219 also inhibited RV duplication in vivo, extenuated the diarrhea and decreased the mortality in neonatal mice infected by RV SA11. Cytopathogenic effects in mucous membrane of small intestine were inhibited. Conclusions Jn219 can inhibit RV duplication either in RV SA11-infected MA104 or in mice models.

  7. Evaluation and characterization of advanced rice mutant line of rice (Oryza sativa), MR219-4 and MR219-9 under drought condition

    International Nuclear Information System (INIS)

    Two advance rice mutant lines, MR219-4 and MR219-9 derived from mutagenesis of Oryza sativa cv. MR219 with gamma radiation at 300 Gy were evaluated in simulated drought condition in the greenhouse at Malaysian Nuclear Agency. The mutants were evaluated simultaneously with ARN1, a drought resistant variety and MR211 a susceptible cultivar as a check. Randomized complete block design with three replicates was used in the experiment. The evaluation and selection were done based on leaf rolling and leaf drying as well as other agronomic traits, such as, number of tillers per plant, plant height, flag leaf area, grain weight per plant, grain yield per plant, 100-grain weight, harvest index, panicle length and plant biomass. The mutants MR219-4 showed moderate tolerance and MR219-9 showed tolerance to drought respectively as compare to the check variety (ARN1, MR211) and control MR219. Leaf rolling, leaf drying, days to flowering and days to maturity are valuable secondary traits that may provide additional information for selection because of associating with the plant survival under water stress. Further research on expression of drought-tolerant lines under different drought conditions is essential in order to identify particular traits that are associated with drought tolerance and high yield potential. Similarly the importance of secondary traits, relative to other putative traits for drought tolerance, needs to be tested in various environments. (author)

  8. 49 CFR 238.219 - Truck-to-car-body attachment.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Truck-to-car-body attachment. 238.219 Section 238... I Passenger Equipment § 238.219 Truck-to-car-body attachment. Passenger equipment shall have a truck-to-car-body attachment with an ultimate strength sufficient to resist without failure the...

  9. 20 CFR 219.40 - Evidence of relationship by equitable adoption-child.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Evidence of relationship by equitable adoption-child. 219.40 Section 219.40 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE... relationship by equitable adoption—child. (a) Preferred evidence. If the claimant is a person who claims to...

  10. 76 FR 80447 - Eighth Meeting: RTCA Special Committee 219: Attitude and Heading Reference Systems (AHRS)

    Science.gov (United States)

    2011-12-23

    ... Federal Aviation Administration Eighth Meeting: RTCA Special Committee 219: Attitude and Heading Reference...). ACTION: Notice of RTCA Special Committee 219: Attitude and Heading Reference Systems (AHRS). SUMMARY: The FAA is issuing this notice to advise the public of the eighth meeting of RTCA Special Committee...

  11. 48 CFR 52.219-4 - Notice of price evaluation preference for HUBZone small business concerns.

    Science.gov (United States)

    2010-10-01

    ... successful offers from small business concerns. (2) The factor of 10 percent shall be applied on a line item... preference for HUBZone small business concerns. 52.219-4 Section 52.219-4 Federal Acquisition Regulations... business concerns. As prescribed in 19.1308(b), insert the following clause: Notice of Price...

  12. 48 CFR 52.219-23 - Notice of Price Evaluation Adjustment for Small Disadvantaged Business Concerns.

    Science.gov (United States)

    2010-10-01

    ... disadvantaged business concern in accordance with 13 CFR 124, subpart B, and a decision on that application is... disadvantaged business concerns that have not waived the adjustment; and (ii) An otherwise successful offer from... Adjustment for Small Disadvantaged Business Concerns. 52.219-23 Section 52.219-23 Federal...

  13. 32 CFR 219.123 - Early termination of research support: Evaluation of applications and proposals.

    Science.gov (United States)

    2010-07-01

    ....123 Early termination of research support: Evaluation of applications and proposals. (a) The... 32 National Defense 2 2010-07-01 2010-07-01 false Early termination of research support: Evaluation of applications and proposals. 219.123 Section 219.123 National Defense Department of...

  14. 48 CFR 652.219-70 - Department of State Subcontracting Goals.

    Science.gov (United States)

    2010-10-01

    ... Subcontracting Goals. 652.219-70 Section 652.219-70 Federal Acquisition Regulations System DEPARTMENT OF STATE... Department of State Subcontracting Goals. As prescribed in 619.708-70, insert a provision substantially the same as follows: Department of State Subcontracting Goals (APR 2004) (a) The offeror shall provide...

  15. 20 CFR 219.30 - When evidence of marriage is required.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false When evidence of marriage is required. 219.30... EVIDENCE REQUIRED FOR PAYMENT Evidence of Relationship § 219.30 When evidence of marriage is required. (a) When an application is filed for benefits. Documentary evidence of marriage is required when...

  16. 20 CFR 219.33 - Evidence of a deemed valid marriage.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Evidence of a deemed valid marriage. 219.33... EVIDENCE REQUIRED FOR PAYMENT Evidence of Relationship § 219.33 Evidence of a deemed valid marriage. (a) Preferred evidence. Preferred evidence of a deemed valid marriage is— (1) Evidence of a ceremonial...

  17. 20 CFR 219.32 - Evidence of a common-law marriage.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Evidence of a common-law marriage. 219.32... EVIDENCE REQUIRED FOR PAYMENT Evidence of Relationship § 219.32 Evidence of a common-law marriage. (a) Preferred evidence. Evidence of a common-law marriage must give the reasons why the informant believes...

  18. 49 CFR 219.102 - Prohibition on abuse of controlled substances.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Prohibition on abuse of controlled substances. 219....102 Prohibition on abuse of controlled substances. No employee who performs covered service may use a controlled substance at any time, whether on duty or off duty, except as permitted by § 219.103....

  19. 48 CFR 2452.219-70 - Small business subcontracting plan compliance.

    Science.gov (United States)

    2010-10-01

    ... of Provisions and Clauses 2452.219-70 Small business subcontracting plan compliance. As prescribed in 2419.708(d), insert the following provision: Small Business Subcontracting Plan Compliance (FEB 2006... the clause at FAR 52.219-9, Small Business Subcontracting Plan. (c) The government will...

  20. 20 CFR 219.53 - Evidence of having a child in care.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Evidence of having a child in care. 219.53... EVIDENCE REQUIRED FOR PAYMENT Other Evidence Requirements § 219.53 Evidence of having a child in care. (a) Preferred evidence of having a child in care. Preferred evidence of having a child in care is— (1) If...

  1. 47 CFR 95.803 - 218-219MHz Service description.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false 218-219MHz Service description. 95.803 Section 95.803 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO... description. (a) The 218-219 MHz Service is authorized for system licensees to provide communication...

  2. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D., Scott

    2011-12-14

    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  3. Extraction and purification of {sup 227}Ac and development of solid {sup 219}Rn source

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Quan; Qiu, Shoukang; Xiao, Detao; Zhou, Yaohui; An, Xiaogang [University of South China, Hengyang (China). Radon Key Laboratory of Hunan Province/School of Nuclear Science and Technology

    2014-04-01

    The method of {sup 227}Ac extraction and purification from high-grade uranium ore and the test results of solid {sup 219}Rn source made from {sup 227}Ac are reported in this paper. With five years of follow-up monitoring, radiochemical purity of {sup 227}Ac and the emanation power of solid {sup 219}Rn source has been checked by emanation method and γ-spectrometry, the results showed that {sup 228}Th, {sup 231}Pa and {sup 226}Ra have been effectively removed and the emanation power of {sup 219}Rn source is about 80%. The long-term test results also showed that the {sup 219}Rn emanation rate remains stable in a wide air humidity range (40% ∝ 90%). Though the {sup 219}Rn source has not been accurately calibrated yet, it has been applied in the research for delay coincidence measurement of {sup 223}Ra. (orig.)

  4. 47 CFR 80.219 - Special requirements for narrow-band direct-printing (NB-DP) equipment.

    Science.gov (United States)

    2010-10-01

    ... reference in accordance with 5 U.S.C. 552(a) and 1 CFR part 51. Copies of these standards can be inspected...-printing (NB-DP) equipment. 80.219 Section 80.219 Telecommunication FEDERAL COMMUNICATIONS COMMISSION... § 80.219 Special requirements for narrow-band direct-printing (NB-DP) equipment. NB-DP and...

  5. 32 CFR 219.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

    Science.gov (United States)

    2010-07-01

    ... proposals for research to be conducted or supported by a Federal Department or Agency. 219.120 Section 219...) MISCELLANEOUS PROTECTION OF HUMAN SUBJECTS § 219.120 Evaluation and disposition of applications and proposals for research to be conducted or supported by a Federal Department or Agency. (a) The department...

  6. 47 CFR 95.219 - (R/C Rule 19) How do I answer correspondence from the FCC?

    Science.gov (United States)

    2010-10-01

    ... from the FCC? 95.219 Section 95.219 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED... You Need to Know § 95.219 (R/C Rule 19) How do I answer correspondence from the FCC? (a) If it appears to the FCC that you have violated the Communications Act or FCC rules, the FCC may send you...

  7. 20 CFR 219.35 - Evidence that a marriage has ended.

    Science.gov (United States)

    2010-04-01

    ... divorce or annulment; or (2) Evidence of the death (See § 219.23) of a party to the marriage. (b) Other..., the claimant must explain the reason therefor and submit other convincing evidence that the...

  8. A Novel Zinc Finger Protein 219-like (ZNF219L) is Involved in the Regulation of Collagen Type 2 Alpha 1a (col2a1a) Gene Expression in Zebrafish Notochord

    OpenAIRE

    Lien, Huang-Wei; Yang, Chung-Hsiang; Cheng, Chia-Hsiung; Hung, Chin-Chun; Liao, Wei-Hao; Hwang, Pung-Pung; Han, Yu-San; Huang, Chang-Jen

    2013-01-01

    The notochord is required for body plan patterning in vertebrates, and defects in notochord development during embryogenesis can lead to diseases affecting the adult. It is therefore important to elucidate the gene regulatory mechanism underlying notochord formation. In this study, we cloned the zebrafish zinc finger 219-like (ZNF219L) based on mammalian ZNF219, which contains nine C2H2-type zinc finger domains. Through whole-mount in situ hybridization, we found that znf219L mRNA is mainly e...

  9. Antibody C219 recognizes an α-helical epitope on P-glycoprotein

    OpenAIRE

    van den Elsen, Jean M. H.; Douglas A Kuntz; Hoedemaeker, Flip J.; Rose, David R

    1999-01-01

    The ABC transporter, P-glycoprotein, is an integral membrane protein that mediates the ATP-driven efflux of drugs from multidrug-resistant cancer and HIV-infected cells. Anti-P-glycoprotein antibody C219 binds to both of the ATP-binding regions of P-glycoprotein and has been shown to inhibit its ATPase activity and drug binding capacity. C219 has been widely used in a clinical setting as a tumor marker, but recent observations of cross-reactivity with other proteins, including the c-erbB2 pro...

  10. MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction

    DEFF Research Database (Denmark)

    Kocerha, Jannet; Faghihi, Mohammad Ali; Lopez-Toledano, Miguel A;

    2009-01-01

    N-methyl-D-aspartate (NMDA) glutamate receptors are regulators of fast neurotransmission and synaptic plasticity in the brain. Disruption of NMDA-mediated glutamate signaling has been linked to behavioral deficits displayed in psychiatric disorders such as schizophrenia. Recently, noncoding RNA...... significantly modulated behavioral responses associated with disrupted NMDA receptor transmission. Furthermore, pretreatment with the antipsychotic drugs haloperidol and clozapine prevented dizocilpine-induced effects on miR-219. Taken together, these data support an integral role for miR-219 in the expression...

  11. 38 CFR 21.219 - Supplies consisting of clothing, magazines and periodicals, and items which may be personally...

    Science.gov (United States)

    2010-07-01

    ... clothing, magazines and periodicals, and items which may be personally used by the veteran. 21.219 Section....219 Supplies consisting of clothing, magazines and periodicals, and items which may be personally used... will be supplied. (b) Furnishing magazines and periodicals. Appropriate past issues of...

  12. 48 CFR 52.219-19 - Small Business Concern Representation for the Small Business Competitiveness Demonstration Program.

    Science.gov (United States)

    2010-10-01

    ... Representation for the Small Business Competitiveness Demonstration Program. 52.219-19 Section 52.219-19 Federal... Representation for the Small Business Competitiveness Demonstration Program. As prescribed in 19.1008(a), insert the following provision: Small Business Concern Representation for the Small Business...

  13. 36 CFR 219.14 - Involvement of State and local governments.

    Science.gov (United States)

    2010-07-01

    ... OF AGRICULTURE PLANNING National Forest System Land and Resource Management Planning Collaborative Planning for Sustainability § 219.14 Involvement of State and local governments. The responsible official... the planning process, including the identification of issues; and (b) Contribute to the...

  14. 7 CFR 1726.405 - Inventory of work orders (RUS Form 219).

    Science.gov (United States)

    2010-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Contract Closeout § 1726.405 Inventory of work orders (RUS Form 219). Upon completion of the contract closeout, the... Policies and Procedures Common to Insured and Guaranteed Electric Loans, of this chapter....

  15. 48 CFR 252.219-7003 - Small business subcontracting plan (DoD contracts).

    Science.gov (United States)

    2010-10-01

    ... AND CONTRACT CLAUSES Text of Provisions And Clauses 252.219-7003 Small business subcontracting plan...-9, Small Business Subcontracting Plan, clause of this contract. (a) Definitions. Historically black... Education to meet the requirements of 34 CFR 608.2. The term also means any nonprofit research...

  16. 49 CFR Appendix C to Part 219 - Post-Accident Testing Specimen Collection

    Science.gov (United States)

    2010-10-01

    ... for forensic toxicology. B. Specimens requested, in order of preference: a. Blood—20 milliliters or...-Accident Testing Blood/Urine Custody and Control Form (49 CFR part 219) (Form FRA F 6180.74 (revised.... Collection of blood and urine specimens is required to be conducted at an independent medical...

  17. Evaluation of 3 Inch SN-219 Failure and S and SX Tank Farm Saltwell Piping

    International Nuclear Information System (INIS)

    Evaluation of direct buried piping currently in use or designated for future Saltwell pumping in S and SX Farms. Documented evaluation of failed S-103 saltwell pumping transfer line 3 inch SN-219. This evaluation is intended to reflect current status of Saltwell piping, when taken in context with referenced documents

  18. 48 CFR 52.219-8 - Utilization of small business concerns.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Utilization of small... Clauses 52.219-8 Utilization of small business concerns. As prescribed in 19.708(a), insert the following clause: Utilization of Small Business Concerns (MAY 2004) (a) It is the policy of the United States...

  19. 20 CFR 219.31 - Evidence of a valid ceremonial marriage.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Evidence of a valid ceremonial marriage. 219... marriage. (a) Preferred evidence. Preferred evidence of a ceremonial marriage is— (1) A copy of the public record of the marriage, certified by the custodian of the record or by a Board employee; (2) A copy of...

  20. 48 CFR 852.219-9 - VA Small business subcontracting plan minimum requirements.

    Science.gov (United States)

    2010-10-01

    ... Provisions and Clauses 852.219-9 VA Small business subcontracting plan minimum requirements. As prescribed in subpart 819.709, insert the following clause: VA Small Business Subcontracting Plan Minimum Requirements... plan, the minimum goals for award of subcontracts to service-disabled veteran-owned small...

  1. 36 CFR 223.219 - Sustainable harvest of special forest products.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Sustainable harvest of....219 Sustainable harvest of special forest products. (a) Sustainable harvest levels. Prior to offering... product's sustainable harvest level. A special forest product's sustainable harvest level is the...

  2. 25 CFR 2.19 - Action by Area Directors and Education Programs officials on appeal.

    Science.gov (United States)

    2010-04-01

    ...—Indian Affairs/Director (Indian Education Programs) shall render written decisions in all cases appealed... 25 Indians 1 2010-04-01 2010-04-01 false Action by Area Directors and Education Programs officials... AND PRACTICE APPEALS FROM ADMINISTRATIVE ACTIONS § 2.19 Action by Area Directors and...

  3. 41 CFR 302-3.219 - Is there a limit on how many times I may receive reimbursement for tour renewal travel?

    Science.gov (United States)

    2010-07-01

    ... many times I may receive reimbursement for tour renewal travel? 302-3.219 Section 302-3.219 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES RELOCATION....219 Is there a limit on how many times I may receive reimbursement for tour renewal travel? (a) If...

  4. Conceptual design report, 219-S secondary containment upgrade, Project W-178

    Energy Technology Data Exchange (ETDEWEB)

    Beyer, J.J. [Kaiser Engineers Hanford Co., Richland, WA (United States)

    1993-05-01

    The 219-S Facility is located in the 200-West Area on the Hanford Site and was constructed in 1951. The facility receives and treats liquid, low-level mixed waste from the 222-S Laboratory prior to transfer of that waste to the SY Tank Farm. The 219-S Facility consists of Cell A containing Tanks 101 and 102 and Cell B containing Tank 103 and a spare space. Project W-178 will modify the 219-S Facility to bring it into compliance with the tank system standards in WAC 173-303-640. The secondary containment upgrade will consist of a stainless steel cell liner in both Cell A and the spare space in Cell B. Additionally, Cell B will be modified by taking Tank 103 out of service and installing a new tank: Tank 104. The construction work will be accomplished in phases to minimize service interruption to the 222-S Laboratory. The proposed design and construction method is the most cost effective of four alternatives evaluated during a value engineering session. Project W-178 is a fiscal year 1995 Line Item. Total estimated construction costs of the project are $2,600,000; other project costs are $710,000. The total project cost is $3,300,000.

  5. Field Trial of 40 Gbit/s ETDM Prototype System over 219 km of Installed Single Mode Fiber

    Institute of Scientific and Technical Information of China (English)

    Sang Soo Lee; Hyun Woo Cho; Sang Kyu Lim; Ki Ho Han; Jin Soo Han; Moo Jung Chu; Je Soo Ko; Kyeong-Mo Yoon; Yong-Gi Lee

    2003-01-01

    Transmission of 40Gbit/s NRZ signal was successfully demonstrated over 219km of installed SMF in KT's Daejeon area network. After transmission, the measured power penalty was 0.5dB for all the tributary channels.

  6. The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model.

    Science.gov (United States)

    Murai, Kiyohito; Sun, Guoqiang; Ye, Peng; Tian, E; Yang, Su; Cui, Qi; Sun, Guihua; Trinh, Daniel; Sun, Olivia; Hong, Teresa; Wen, Zhexing; Kalkum, Markus; Riggs, Arthur D; Song, Hongjun; Ming, Guo-li; Shi, Yanhong

    2016-03-11

    Dysregulated expression of miR-219, a brain-specific microRNA, has been observed in neurodevelopmental disorders, such as schizophrenia (SCZ). However, its role in normal mammalian neural stem cells (NSCs) and in SCZ pathogenesis remains unknown. We show here that the nuclear receptor TLX, an essential regulator of NSC proliferation and self-renewal, inhibits miR-219 processing. miR-219 suppresses mouse NSC proliferation downstream of TLX. Moreover, we demonstrate upregulation of miR-219 and downregulation of TLX expression in NSCs derived from SCZ patient iPSCs and DISC1-mutant isogenic iPSCs. SCZ NSCs exhibit reduced cell proliferation. Overexpression of TLX or inhibition of miR-219 action rescues the proliferative defect in SCZ NSCs. Therefore, this study uncovers an important role for TLX and miR-219 in both normal neurodevelopment and in SCZ patient iPSC-derived NSCs. Moreover, this study reveals an unexpected role for TLX in regulating microRNA processing, independent of its well-characterized role in transcriptional regulation.

  7. MicroRNA-219-5p Inhibits Morphine-Induced Apoptosis by Targeting Key Cell Cycle Regulator WEE1.

    Science.gov (United States)

    Lou, Wei; Zhang, Xingwang; Hu, Xiao-Ying; Hu, Ai-Rong

    2016-01-01

    BACKGROUND To identify the effects of microRNA (miR)-219-5p on morphine-induced apoptosis by targeting WEE1. MATERIAL AND METHODS Forty Balb/C mice (Toll-like receptor 9, TLR9 knockout) were randomly allocated to the experimental and control groups (20 in each group). The baseline miR-219-5p expression was detected using quantitative real-time PCR (qRT-PCR). After morphine was injected at 6 h on the 2nd and 6th days, experimental and control groups received miR-219-5p mimics or miRNA-negative control (NC), respectively, compound injection. Tissues and cells were later obtained from subjects in each group separately after mice were killed. TUNEL assay was used to investigate apoptosis in both groups. RAW264.7 cells were treated with miR-219-5p mimics and controls, respectively. After 24 h, 10 μM of morphine was added at 24 h. Cell apoptosis was assessed by flow cytometer. The WEE1 and Phospho-cdc2 (Tyr15) expressions were examined by Western blotting. RESULTS MiR-219-5p expression in the experimental group was significantly lower than that in the control group (PWEE1 and Tyr15 protein expressions in the miR-219-5p NC group and morphine group were obviously stronger than those in the blank control group (all PWEE1 and Tyr15 protein expressions were significantly lower compared with those in the miR-219-5p NC group and morphine group (all PWEE1 to suppress Tyr15 expressions and activate Cdc2, thus inhibiting the morphine-induced macrophage apoptosis. PMID:27253431

  8. Inverse Compton X-rays from the radio galaxy 3C 219

    CERN Document Server

    Comastri, A; Dallacasa, D; Bondi, M; Pedani, M; Setti, G

    2003-01-01

    We report the results from a Chandra observation of the powerful nearby (z=0.1744) radio galaxy 3C 219. We find evidence for non-thermal X-ray emission from the radio lobes which fits fairly well with a combination of inverse Compton scattering of Cosmic Microwave Background radiation and of nuclear photons with the relativistic electrons in the lobes. The comparison between radio synchrotron and IC emission yields a magnetic field strength significantly lower (about a factor 3) than that calculated under minimum energy conditions; the source energetics is then dominated by the relativistic particles.

  9. Equation modifying program, L219 (EQMOD). Volume 2: Supplemental system design and maintenance document

    Science.gov (United States)

    Hirayama, M. Y.; Clemmons, R. E.; Miller, R. D.

    1979-01-01

    A digital computer program, L219 (EQMOD), available for execution on the CDC 6600 is described. The program modifies matrices according to card input instructions and prepares magnetic files of matrices suitable for use in the linear systems analysis program (QR) and the random harmonic analysis program L221 (TEV156). The particular field of application of the program is the modification of the theoretical equations of motion and load equations generated in DYLOFLEX by the equation of motion program (L217) and the load equation program (L218), respectively.

  10. Polychlorinated biphenyls (PCB) analysis report for solid sample from 219S tank 101

    Energy Technology Data Exchange (ETDEWEB)

    Diaz, L.A.

    1998-02-04

    One waste sample that was obtained with solids from tank 101 of 219S via a peristaltic pump equipped with a stainless steel tube and Norprene tubing (Phthalate free) was obtained in a glass jar with teflon lid was analyzed (with duplicate, matrix spike, and matrix spike duplicate) for PCBs as Aroclor mixtures by the Inorganic/Organic Chemistry Group. A soxhlet extraction procedure was used for extraction of the Aroclors from the sample. Analysis was performed using dual column confirmation gas chromatography/electron capture detection (GC/ECD). Results are presented.

  11. Polychlorinated biphenyls (PCB) analysis report for solid sample from 219S tank 101

    International Nuclear Information System (INIS)

    One waste sample that was obtained with solids from tank 101 of 219S via a peristaltic pump equipped with a stainless steel tube and Norprene tubing (Phthalate free) was obtained in a glass jar with teflon lid was analyzed (with duplicate, matrix spike, and matrix spike duplicate) for PCBs as Aroclor mixtures by the Inorganic/Organic Chemistry Group. A soxhlet extraction procedure was used for extraction of the Aroclors from the sample. Analysis was performed using dual column confirmation gas chromatography/electron capture detection (GC/ECD). Results are presented

  12. 219.3 W CW diode-side-pumped 1123 nm Nd:YAG laser

    Science.gov (United States)

    Li, C. Y.; Bo, Y.; Xu, Y. T.; Yang, F.; Wang, Z. C.; Wang, B. S.; Xu, J. L.; Gao, H. W.; Peng, Q. J.; Cui, D. F.; Xu, Z. Y.

    2010-07-01

    We demonstrate a high power continuous wave (CW) diode-side-pumped Nd:YAG laser operating at 1123 nm with a plano-plano configuration. By means of precise coating, a single 1123 nm wavelength is achieved. Under the pump power of 1080 W, an output power of 219.3 W is obtained, which corresponds to an optical-optical conversion efficiency of 20.3%. To the best of our knowledge, this is the highest output power for CW 1123 nm laser based on Nd:YAG crystal.

  13. Synthesis, radiochemistry and biological evaluation of a new somatostatin analogue (SDZ 219-387) labelled with technetium-99m

    International Nuclear Information System (INIS)

    A new derivative of octreotide SDZ 219-387 [PnAO-(D)Phe1-octreotide] was synthesized, which binds specifically and with high affinity to somatostatin receptors in vitro (pKi=9.79±0.16). This new somatostatin analogue chelates technetium-99m under mild labelling conditions in good yields. The resulting [99mTc]SDZ 219-387 was stable up to 6 h after labelling and could be isolated in a pure radiochemical and chemical form by high-perfomance liquid chromatographic purification. The intravenous administration of purified [99mTc]SDZ 219-387 revealed that the radioligand was rapidly cleared from circulation, and tumour uptake of 0.38% ID/g was observed at 1.5 h post injection. [99mTc]SDZ 219-387 specifically interacted with somatostatin binding sites on the tumour. However, the radioligand is highly lipophilic and excreted mainly through the hepatobiliary system. As a consequence, [99mTc]SDZ 219-387 exhibits increased background activity and therefore is not appropriate for the in vivo visualization of somatostatin receptor-positive tumours and/or their metastases in the abdomen. (orig.)

  14. A Novel Functional Missense Mutation p.T219A in Type 1 Gaucher's Disease

    Institute of Scientific and Technical Information of China (English)

    Lin-YuLiu; Fei Liu; Si-Chen Du; Sha-Yi Jiang; Hui-Jun Wang; Jin Zhang; Wei Wang

    2016-01-01

    Background:Gaucher's disease (GD) is an autosomal recessive disorder caused by a deficiency of acid β-glucosidase (glucocerebrosidase [GBA])that results in the accumulation of glucocerebroside within macrophages.Many mutations have been reported to be associated with this disorder.This study aimed to discover more mutations and provide data for the genetic pattern of the gene,which will help the development of quick and accurate genetic diagnostic tools for this disease.Methods:Genomic DNA was obtained from peripheral blood leukocytes of the patient and Sanger sequencing is used to sequence GBA gene.Sequence alignments of mammalian β-GBA (GCase) and three-dimensional protein structure prediction of the mutation were made.A construct of this mutant and its compound heterozygous counterpart were used to measure GCase in vitro.Results:GCase is relatively conserved at p.T219A.This novel mutation differs from its wild-type in structure.Moreover,it also causes a reduction in GCase enzyme activity.Conclusion:This novel mutation (c.655A>G,p.T219A) is a pathogenic missense mutation,which contributes to GD.

  15. Photo-dynamical mass determination of the multi-planetary system K2-19

    CERN Document Server

    Barros, S C C; Demangeon, O; Tsantaki, M; Santerne, A; Armstrong, D J; Barrado, D; Brown, D; Deleuil, M; Lillo-Box, J; Osborn, H; Pollacco, D; Abe, L; Andre, P; Bendjoya, P; Boisse, I; Bonomo, A S; Bouchy, F; Bruno, G; Cerda, J Rey; Courcol, B; Díaz, R F; Hébrard, G; Kirk, J; Lachurié, J C; Lam, K W F; Martinez, P; McCormac, J; Moutou, C; Rajpurohit, A; Rivet, J -P; Spake, J; Suarez, O; Toublanc, D; Walker, S R

    2015-01-01

    K2-19 is the second multi-planetary system discovered with K2 observations. The system is composed of two Neptune size planets close to the 3:2 mean-motion resonance. To better characterise the system we obtained two additional transit observations of K2-19b and five additional radial velocity observations. These were combined with K2 data and fitted simultaneously with the system dynamics (photo-dynamical model) which increases the precision of the transit time measurements. The higher transit time precision allows us to detect the chopping signal of the dynamic interaction of the planets that in turn permits to uniquely characterise the system. Although the reflex motion of the star was not detected, dynamic modelling of the system allowed us to derive planetary masses of $M_b= 44 \\pm 12\\, M_{\\oplus}$ and $M_c = 15.9 \\pm 7.0\\, M_{\\oplus}$ for the inner and the outer planets respectively, leading to densities close to Uranus. We also show that our method allows the derivation of mass ratios using only the 80...

  16. Photodynamical mass determination of the multiplanetary system K2-19

    Science.gov (United States)

    Barros, S. C. C.; Almenara, J. M.; Demangeon, O.; Tsantaki, M.; Santerne, A.; Armstrong, D. J.; Barrado, D.; Brown, D.; Deleuil, M.; Lillo-Box, J.; Osborn, H.; Pollacco, D.; Abe, L.; Andre, P.; Bendjoya, P.; Boisse, I.; Bonomo, A. S.; Bouchy, F.; Bruno, G.; Cerda, J. Rey; Courcol, B.; Díaz, R. F.; Hébrard, G.; Kirk, J.; Lachurié, J. C.; Lam, K. W. F.; Martinez, P.; McCormac, J.; Moutou, C.; Rajpurohit, A.; Rivet, J.-P.; Spake, J.; Suarez, O.; Toublanc, D.; Walker, S. R.

    2015-12-01

    K2-19 is the second multiplanetary system discovered with K2 observations. The system is composed of two Neptune size planets close to the 3:2 mean-motion resonance. To better characterize the system we obtained two additional transit observations of K2-19b and five additional radial velocity observations. These were combined with K2 data and fitted simultaneously with the system dynamics (photodynamical model) which increases the precision of the transit time measurements. The higher transit time precision allows us to detect the chopping signal of the dynamic interaction of the planets that in turn permits to uniquely characterize the system. Although the reflex motion of the star was not detected, dynamic modelling of the system allowed us to derive planetary masses of Mb = 44 ± 12 M⊕ and Mc = 15.9 ± 7.0 M⊕ for the inner and the outer planets, respectively, leading to densities close to Uranus. We also show that our method allows the derivation of mass ratios using only the 80 d of observations during the first campaign of K2.

  17. Effect of miR-219-5p on malignant phenotype of glioblastoma cells%MiR-219-5p对人脑成胶质细胞瘤恶性表型的影响

    Institute of Scientific and Technical Information of China (English)

    刘彦伟; 颜伟; 王永志; 张伟; 游赣; 唐铠

    2012-01-01

    目的:探讨miR-219-5p对人脑成胶质细胞瘤(glioblastoma,GBM)的恶性表型——增殖、凋亡和侵袭的影响,初步寻找与miR-219-5p发挥抑癌作用有关的靶点基因.方法:在60例GBM组织中分析miR-219-5p表达水平及mRNA表达谱,筛选与miR-219-5p表达量呈负相关的mRNA;选取前50个相关性最大的mRNA,用基因功能分析软件DAVID从中筛选出与GBM恶性进展相关的2组mRNA;最后用4个在线靶点预测网站从这2组中预测miR-219-5p的潜在靶点.采用MTT法、流式细胞术和Transwell实验初步验证miR-219-5p对GBM细胞增殖、凋亡和侵袭的影响.结果:60例GBM组织中筛出14个与增殖和凋亡相关的基因和5个与侵袭相关的基因(P<0.001);在这19个候选基因中预测到4个基因(TWIST1、MYO1B、WEE1和SPRED2)是miR-219-5p的潜在靶点.实验初步证明,miR-219-5p能够抑制GBM细胞的增殖和侵袭以及促进细胞凋亡(P<0.05).结论:MiR-219-5p可能通过作用于多个靶点对GBM的恶性表型起到抑制作用.%Objective: To investigate the effect of rniR-219-5p on malignant phenotype of glioblastoma cells involving proliferation, apoptosis and invasion, and to preliminarily determine the candidate target genes of miR-219-5p related to the inhibition of cancer. Methods: The inverse relationship between mRNAs and miR-219-5p in glioblastoma tissues from sixty cases was obtained by analysis of miR-219-5p expression level and mRNA expression profiling. DAVID software for functional analysis was employed to analyze the functions of the top 50 mRNAs and screen out two sets of mRNAs related to glioblastoma progression. The target genes of miR-219-5p were screened out from the two sets of miRNAs on four websites of online target-binding prediction. MTT assay, flow cytometry (FCM) assay and Transwell assay were performed to detect the effects of miR-219-5p on the proliferation, apoptosis and invasion of human glioblastoma cells, respectively. Results: Fourteen

  18. 222-S radioactive liquid waste line replacement and 219-S secondary containment upgrade, Hanford Site, Richland, Washington

    International Nuclear Information System (INIS)

    The U.S. Department of Energy (DOE) is proposing to: (1) replace the 222-S Laboratory (222-S) radioactive liquid waste drain lines to the 219-S Waste Handling Facility (219-S); (2) upgrade 219-S by replacing or upgrading the waste storage tanks and providing secondary containment and seismic restraints to the concrete cells which house the tanks; and (3) replace the transfer lines from 219-S to the 241-SY Tank Farm. This environmental assessment (EA) has been prepared in compliance with the National Environmental Policy Act (NEPA) of 1969, as amended, the Council on Environmental Quality Regulations for Implementing the Procedural Provisions of NEPA (40 Code of Federal Regulations [CFR] 1500-1508), and the DOE Implementing Procedures for NEPA (10 CFR 1021). 222-S is used to perform analytical services on radioactive samples in support of the Tank Waste Remediation System and Hanford Site environmental restoration programs. Activities conducted at 222-S include decontamination of analytical processing and support equipment and disposal of nonarchived radioactive samples. These activities generate low-level liquid mixed waste. The liquid mixed waste is drained through pipelines in the 222-S service tunnels and underground concrete encasements, to two of three tanks in 219-S, where it is accumulated. 219-S is a treatment, storage, and/or disposal (TSD) unit, and is therefore required to meet Washington Administrative Code (WAC) 173-303, Dangerous Waste Regulations, and the associated requirements for secondary containment and leak detection. The service tunnels are periodically inspected by workers and decontaminated as necessary to maintain as low as reasonably achievable (ALARA) radiation levels. Although no contamination is reaching the environment from the service tunnels, the risk of worker exposure is present and could increase. 222-S is expected to remain in use for at least the next 30 years to serve the Hanford Site environmental cleanup mission

  19. 固体219Rn 源的γ能谱法放射性纯度检验%Determination of Radioactivity Purity of Solid 219 Rn Source by γ-ray Spectrometry

    Institute of Scientific and Technical Information of China (English)

    唐泉; 安小刚; 丘寿康

    2014-01-01

    对利用从铀矿石中提取得到的227 Ac制备的固体219 Rn源进行了γ能谱分析,确定了227 Ac的4个子体核素227 T h、223 Ra、219 Rn和211 Bi的活度,并分析了能对219 Rn造成干扰的222 Rn、220 Rn母体核素226 Ra、224 Ra的活度。待227 Ac及其子体达到放射性平衡后,通过测量227 Th的235.97、256.25 keV ,223 Ra的154.21 keV ,219 Rn的401.81 keV ,211 Bi的351.059 keV共5条γ射线,最终确定固体219 Rn源中227 T h、223 Ra、219 Rn和211 Bi的活度为(1069±3)、(1079±5)、(1095±13)、(1096±14)和(11089±4) Bq ,固体219 Rn源的平均活度为(1093±8) Bq;通过测量224 Ra子体212 Pb的238.632 keV、208 T l的583.191 keVγ射线以及226 Ra子体214 Bi的609.312、1120.287 keV γ射线得到226 Ra与224 Ra的平均活度分别为5.12 Bq及0.433 Bq ,远低于固体219 Rn源的平均活度,说明固体219 Rn源放射性纯度较高。以上结果表明,此源有望制成标准固体219 Rn源以用于延迟符合法测223 Ra、227 Ac装置的刻度。%Radioactivity purity of the solid 219 Rn source made using 227 Ac extracted from uranium ore were determined by γ‐spectrometry .The activities of 227 Th ,223 Ra ,219 Rn and 211 Bi produced by the decay of 227 Ac and the contents of 226 Ra ,224 Ra w hich generates 222 Rn ,220 Rn to affect the purity of actinide in this source were analyzed after 227 Ac in radioactive equilibrium with its daughter nuclides . The γ‐ray energy used for the determination of these daughter nuclides of 227 Ac are 235.97 ,256.25 keV for 227 Th , 154.21 keV for 223Ra ,401.81 keV for 219Rn ,and 351.059 keV for 211Bi .Through the analysis ,the results are acquired that their activities are (1 069 ± 3 ) , (1 079 ± 5 ) , (1 095 ± 13) ,(1 096 ± 14) and (11 089 ± 4) Bq respectively ,and the average activity of solid 219 Rn source is (1 093 ± 8) Bq .The activities of 226 Ra and 224 Ra in this source are 5.12 Bq and 0.433 Bq respectively

  20. Measurement of the (211)Pb half-life using recoil atoms from (219)Rn decay.

    Science.gov (United States)

    Aitken-Smith, P M; Collins, S M

    2016-04-01

    The radioactive half-life of (211)Pb was measured, by α-particle counting of samples of radiochemically pure (211)Pb in equilibrium with its α-emitting progeny, (211)Bi and (211)Po. The samples were prepared by the collection of (215)Po recoil atoms from the decay of the (219)Rn decay progeny produced from a (223)Ra sample onto stainless steel discs. The radioactive decay of the (211)Pb was measured utilising a 2π proportional counter operating on the α plateau. A half-life of 36.164 (13)min was determined, which is in agreement with currently available literature. A full uncertainty budget is presented. A recommended half-life of T1/2((211)Pb)=36.161 (17)min has been evaluated from the current literature values. PMID:26773817

  1. Downregulation of miR-219 enhances brain-derived neurotrophic factor production in mouse dorsal root ganglia to mediate morphine analgesic tolerance by upregulating CaMKIIγ

    Science.gov (United States)

    Hu, Xue-Ming; Cao, Shou-Bin; Zhang, Hai-Long; Lyu, Dong-Mei; Chen, Li-Ping; Xu, Heng; Pan, Zhi-Qiang

    2016-01-01

    Background Increasing evidence suggests that microRNAs are functionally involved in the initiation and maintenance of pain hypersensitivity, including chronic morphine analgesic tolerance, through the posttranscriptional regulation of pain-related genes. We have previously demonstrated that miR-219 regulates inflammatory pain in the spinal cord by targeting calcium/calmodulin-dependent protein kinase II gamma (CaMKIIγ). However, whether miR-219 regulates CaMKIIγ expression in the dorsal root ganglia to mediate morphine tolerance remains unclear. Results MiR-219 expression was downregulated and CaMKIIγ expression was upregulated in mouse dorsal root ganglia following chronic morphine treatment. The changes in miR-219 and CaMKIIγ expression closely correlated with the development of morphine tolerance, which was measured using the reduction of percentage of maximum potential efficiency to thermal stimuli. Morphine tolerance was markedly delayed by upregulating miR-219 expression using miR-219 mimics or downregulating CaMKIIγ expression using CaMKIIγ small interfering RNA. The protein and mRNA expression of brain-derived neurotrophic factor were also induced in dorsal root ganglia by prolonged morphine exposure in a time-dependent manner, which were transcriptionally regulated by miR-219 and CaMKIIγ. Scavenging brain-derived neurotrophic factor via tyrosine receptor kinase B-Fc partially attenuated morphine tolerance. Moreover, functional inhibition of miR-219 via miR-219-sponge in naive mice elicited thermal hyperalgesia and spinal neuronal sensitization, which were both suppressed by CaMKIIγ small interfering RNA or tyrosine receptor kinase B-Fc. Conclusions These results demonstrate that miR-219 contributes to the development of chronic tolerance to morphine analgesia in mouse dorsal root ganglia by targeting CaMKIIγ and enhancing CaMKIIγ-dependent brain-derived neurotrophic factor expression. PMID:27599867

  2. MicroRNA-219-2-3p functions as a tumor suppressor in gastric cancer and is regulated by DNA methylation.

    Directory of Open Access Journals (Sweden)

    Huizi Lei

    Full Text Available BACKGROUND AIMS: Gastric cancer is the most frequent gastrointestinal tumor in adults and is the most lethal form of human cancer. Despite of the improvements in treatments, the underlying mechanism of gastric carcinogenesis is not well known. To define novel modulators that regulate susceptibility to tumorgenesis, we focused on miR-219-2-3p. METHODS: Quantitative RT-PCR was employed to investigate the level of miR-219-2-3p in gastric cancer (GC tissues (n = 113 and their matched adjacent normal tissues (n = 113. In vitro cell proliferation, apoptosis assays, cell migration, and invasion assays were performed to elucidate biological effects of miR-219-2-3p. Since silencing of miRNA by promoter CpG island methylation may be an important mechanism in tumorgenesis, GC cells were treated with 5-aza-2'-deoxycytidine and trichostatin A, and expression changes of miR-219-2-3p were subsequently examined by quantitative RT-PCR. Finally, the methylation status of CpG island upstream of miR-219-2-3p was analyzed by methylation-specific PCR in GC tissues (n = 22. RESULTS: miR-219-2-3p was down-regulated in GC and cell lines. In addition, the experiments documented the lower expression of miR-219-2-3p in GC specimens with higher grade and later stage tumors. Meanwhile, miR-219-2-3p exerted antiproliferative, proapoptotic, and antimetastatic roles and reduced levels of p-ERK1/2 in GC cells. Furthermore, 5-aza-2'-deoxycytidine and trichostatin A increased the expression (~2 fold of miR-219-2-3p in GC cells. By methylation-specific PCR, DNA methylation in the upstream region of miR-219-2-3p was detected in both adjacent normal tissues and cancer tissues. As expected, the methylation level was considerably higher in the miR-219-2-3p down-regulated group than up-regulated group. CONCLUSIONS: miR-219-2-3p is potentially involved in gastric cancer progression and metastasis by regulating ERK1/2-related signal pathways, which may provide a novel therapeutic strategy

  3. 76 FR 8620 - Airworthiness Directives; Pratt & Whitney JT8D-209, -217, -217A, -217C, and -219 Turbofan Engines

    Science.gov (United States)

    2011-02-15

    ...We are superseding an existing airworthiness directive (AD) for Pratt & Whitney (PW) JT8D-209, -217, -217A, -217C, and -219 turbofan engines. That AD currently requires revisions to the engine manufacturer's time limits section (TLS) to include enhanced inspection of selected critical life-limited parts at each piece-part opportunity. This new AD modifies the TLS of the manufacturer's engine......

  4. Germination Response of MR 219 Rice Variety to Different Exposure Times and Periods of 2450 MHz Microwave Frequency

    OpenAIRE

    Daryush Talei; Alireza Valdiani; Mahmood Maziah; Mohammad Mohsenkhah

    2013-01-01

    Germination is a key process in plants' phenological cycles. Accelerating this process could lead to improvment of the seedling growth as well as the cultivation efficiency. To achieve this, the effect of microwave frequency on the germination of rice seeds was examined. The physiological feedbacks of the MR 219 rice variety in terms of seed germination rate (GR), germination percentage (GP), and mean germination time (MGT) were analyzed by exposing its seeds to 2450 MHz of microwave frequenc...

  5. {sup 18}F-labeling and biodistribution of the novel fluoro-quinolone antimicrobial agent, trovafloxacin (CP 99,219)

    Energy Technology Data Exchange (ETDEWEB)

    Babich, John W.; Rubin, Robert H.; Graham, Wendy A.; Wilkinson, Robert A.; Vincent, John; Fischman, Alan J

    1996-11-01

    [{sup 18}F]CP 99,219 [(1{alpha},5{alpha},6{alpha})-7-(6-amino-3-azabicyclo [3.1.0]hex-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid] was prepared by {sup 18}F for {sup 19} exchange followed by reverse-phase HPLC purification. Studies of the effects of reaction time and temperature on {sup 18}F incorporation demonstrated that heating 1.0 mg of CP 99,219 in 0.5 cc of DMSO with 4.5 mg of K{sub 2}CO{sub 3} and 24 mg of Kryptofix for 15 min at 160 deg. C results in the optimal compromise between radiochemical yield and purity. This method routinely provides radiochemical yields of 15-30% [EOS] with radiochemical purities of >97%. Varying the concentration of CP 99,219 in the reaction mixture had no effect on yield. Biodistribution studies in rats demonstrated that significant concentrations of drug accumulate in most tissues. The tissues with the highest concentrations of drug were intestine, liver, kidney, and stomach.

  6. Clinical analysis for 219 cases of moderate and severe ovarian hyperstimulation syndrome%中、重度卵巢过度刺激综合征219例临床分析

    Institute of Scientific and Technical Information of China (English)

    胡晶晶; 魏兆莲; 周平; 邹薇薇; 曹云霞

    2011-01-01

    Objective To investigate the clinical characteristics, treatment and prevention of ovarian hypers-timulation syndrome (OHSS) in assisted reproduction techniques (ART). Methods Clinical data of 219 moderate and severe OHSS cases who were received in vitro fertilization- embryo transfer (IVF- ET) or intracytoplasmic sperm injection (ICSI) in the First Affiliated Hospital of Anhui Medical University from March 2007 to December 2010, were analyzed retrospectively. Results OHSS occurred after controlled ovarian hyperstimulation treatment, the incidence was about 4. 2% (219/5 176). 177 (80. 8%) were moderate OHSS and 42 (19. 2%) were severe OHSS. The distribution of severe OHSS patients between early group (18 cases, 8.2%) and late group (24 cases, 11.0%) was signifiant different (P0. 05).Conclusions The clinical features of early and late onset group were quite different. Multiple pregnance was the risk factor of OHSS. Cryopreserving all embryos on the day of transfer or choose single embryo transfer can reduce the duration of OHSS symptoms effectively .%目的 研究辅助生殖技术中卵巢过度刺激综合征(ovarian hyperstimulation syndrome,OHSS)的临床特点、治疗和预防.方法 对安徽医科大学第一附属医院生殖中心2007年3月至2010年12月行体外受精-胚胎移植(in vitro fertilization- embryo transfer,IVF- ET)和卵细胞浆内单精子注射(intracytoplasmic sperm injection,ICSI)中发生中、重度OHSS的219例患者的临床资料进行回顾性分析.结果 在219例患者中,OHSS发生率的为4.2% (219/5 176),其中重度OHSS 42例(19.2%),中度OHSS 177例(80.8%).早发组重度OHSS发生率(18例,8.2%)与晚发组(24例,11.0%)比较,差异有统计学意义(P<0.001);取卵后发生OHSS的时间为l~19d,早发组平均发生时间为(2.2±1.8)d,晚发组为(12.4±3.4)d(P<0.001).主要表现为腹胀、恶心、呕吐和少量腹水患者占80.8% (177/219);合并胸水、少尿、血液浓缩、水电解

  7. INFERIOR TURBINECTOMY FOR NASAL OBSTRUCTION-STUDY O F 219 CASES

    Directory of Open Access Journals (Sweden)

    Santhosh

    2013-03-01

    Full Text Available ABSTRACT: OBJECTIVE : To determine the success rate of inferior turbine ctomy for nasal obstruction. To study complications of inferior turb inectomy. To study the histopathological changes in the inferior turbinate specimens. METHOD : This prospective, single blinded, randomized study of 219 consecutive patients carried out in two tertiary le vel centres from January 2010 to October 2011. The patients were asse ssed preoperatively and postoperatively both subjectively and objectively. The patients who were refractory to the directed conservative treatment for chronic nasal obstruction underwent i nferior turbinectomy on both sides and septoplasty if required. The inferior turbinectomy spe cimen was sent for histopathological examination. NOSE Questionnaires were used for subj ective assessment and rigid nasal endoscopy used for objective assessment. Follow up do ne at 1 week, 1 month and 6 months after surgery. Friedman test applied for assessment o f the improvement. RESULTS : 92 % (n=203 of patients relieved of nasal obstruction fo r which they approached. The improvement is statistically significant both subjectively and objectively. The common complications in present study is postoperative nasal synechia which o ccurred in 5% (n=10. Bleeding occurred in 4%(n=8. Dryness and crusting occurred in 2%(n=4 and foul odour in 2% (n=4. The present study also showed that most common cause for turbinate enlargement is chronic nonspecific inflammatory hypertrophy followed by aller gic turbinate hypertrophy. CONCLUSION : -The results show that inferior turbinectomy is t he good method of achieving relief from the nasal obstruction with minimal morb idity. Histopathological examination showed that most common cause of turbinate enlargem ent is chronic non specific turbinate hypertrophy and it proves beyond doubt that unnecessa ry excessive antiallergic treatment should be avoided in patients with chronic nasal obs truction KEY WORDS: inferior

  8. Association between apolipoprotein E promoter-219G/T polymorphism and total cholesterol level in patients with Alzheimer disease

    Institute of Scientific and Technical Information of China (English)

    Fang Liu; Xiao Sun; Jing Wang; Yan Kong; Li Cui; Xiangdang Shi

    2006-01-01

    BACKGROUND: Many researches have suggested that apolipoprotein E (APOE) and total cholesterol metabolism are closely related with dementia. In the supposed theory, 219 site of APOE promoter region is near gene coding region, so its polymorphism may result in the abnormality of APOE gene and protein expression,and finally lead to dementia.OBJECTIVE: To observe the association between APOE promoter-219G/T polymorphisms with serum total cholesterol in patients with Alzheimer disease, and compare it with non-dementia people.DESIGN: Case-control, comparative observation.SETTING: Department of Neurology, Fengtian Hospital of Shenyang Medical College.PARTICIPANTS: Fifty-five dementia patients including 27 males and 28 females aged (66±3) years and treated in the Department of Neurology, Fengtian Hospital were selected from January 2002 to December 2005 as the Alzheimer disease group. They all diagnosed according to the DSM- Ⅳ diagnostic criteria of Alzheimer disease instituted by American Psychiatry Association in 1994. Meanwhile, 44 none-dementia patients including 21 males and 23 females aged (66±3) years were selected from other clinical departments of Fengtian Hospital as control group. All the participants were informed the detection and agreed.METHODS: Genomic DNA was extracted from the peripheral blood of all subjects, then "NEST"PCR, DNA sequence and enzyme digestion were adopted to detect the expression of APOE promoter-219 polymorphism,following by biomedical statistics analysis based on the clinical total cholesterol level.MAIN OUTCOME MEASURES: Polymorphism of APOEpromoter-219 G/T and total cholesterol level.RESULTS: All 55 dementia patients and 44 non-dementia ones were involved in the result analysis. ①Allele and genotype frequency: The T allele frequency of the Alzheimer disease group was significantly higher than that in the control group [88.2% (97/110), 54.5% (48/88)], while G allele frequency was remarkably lower than that in the control group [11

  9. Amylose Content and Grain Length of New Rice Transgressive Variants Derived from a Cross Between O. rufipogon and Malaysian Rice Cultivar MR219

    Directory of Open Access Journals (Sweden)

    Parviz Fasahat

    2012-01-01

    Full Text Available Amylose content is one of the important grain quality properties of rice. A total of 10 new rice genotypes (BC2F7 generation derived from a cross between O. rufipogon Griff. accession IRGC105491 and O. sativa subspecies indica cv. MR219 with high yield were evaluated for amylose content in three environments in Peninsular Malaysia. One of the parents, a popular high yielding Malaysian rice cultivar MR219 was used as a check. Based on the average amylose content across the environments, the genotype G13 showed significantly (p < 0.05 different amylose content (23.88 % in comparison to other genotypes. Two genotypes G13 (25.7% and G15 (25.6% were higher than MR219 (25.1% in terms of amylose content in Sungai Besar environment. There was a positive (r2=0.018 but no significant correlation between amylose content and grain length.

  10. 冠心病患者ABCA1基因R219K多态性分析%Polymorphism of R219K of ABCA1 gene in patients with coronary artery disease

    Institute of Scientific and Technical Information of China (English)

    王旭东; 傅研; 姜惠杰

    2004-01-01

    目的:探讨三磷酸腺苷(ATP)结合盒子转运体1(ATP-binding cassette transporter 1;ABC1,ABCAI)基因多态性与冠心病(CHD)发病和病情程度的相关性.方法:使用多聚合酶链式反应(PCR)和错配酶促切割法检测了222例CHD患者和278例健康对照者的DNA,分析了该基因编码区R219K多态性位点的不同基因型频率,其分布特点以及与血脂、CHD疾病程度的相关性.结果:R219K的变异等位基因频率CHD组和对照组分别为43.9%、50.2%,P <0.05,变异基因型(KK)携带者频率在急性冠状动脉综合征(ACS)组:稳定型心绞痛(SAP)组:对照组为20.0%:26.9%:27.7%,其ACS组与对照组差异有统计学意义(P<0.05),而SAP组与对照组差异无统计学意义(P>0.05).CHD组中KK基因型携带者的三酰甘油(TG)水平低于RR基因型携带者[(1.31±0.62):(1.56±0.63)mmol/L,P<0.05],而高密度脂蛋白水平高于后者[(1.01±0.12):(0.96±0.14)mmol/L,P<0.05].结论:ABCA1基因R219K多态性不仅与血脂水平并与CHD发病及病情严重程度明显相关.由于总体对象中K等位基因具有较高的频率(47%),计算的人群归因危险度结果提示,使本研究对象中CHD的患者减少了12%.

  11. miR-219基因及其靶基因CAMK2G多态性与精神分裂症的关联研究%Association study of the polymorphisms in miR-219 gene and its target gene CAMK2G with schizophrenia

    Institute of Scientific and Technical Information of China (English)

    张燕霞; 汪栋祥; 李华芳; 傅迎美; 禹顺英

    2013-01-01

    Objectives This study aims to determine the potential association between polymorphisms in miR-219 gene and its target gene CAMK2G and schizophrenia. Methods Two SNPs (rs 107822 in miR-219 and rs2306327 in CAMK2G)were selected and genotyped by the TaqMan genotyping assay in a case-control study with 1041 schizophrenia cases and 953 healthy controls in Chinese Han population. Secondary structure of miR-219 with rs 107822 was constructed via the CentroidFold software. Results The allele frequency distribution of rs 107822 was statistically different between schizophrenia and healthy controls (χ2=7.33, P=0.007). Logistic regression analyses showed that the additive inheritance model was the best model for the gennotyping data of rs 107822 (P=0.0072). Individuals who carried the C allele were associated with significantly decreased risk of developing schizophrenia (OR=0.84, 95 % CI=0.74~ 0.95). Structure prediction by software found that secondary structure of miR-219 primary trancript (pri-miR-219) was changed when the T allele at rs 107822 was mutated to Callele. No statistical difference was found between cases and controls with regard to the allele or genotype distribution of rs2306327 .Conclusions These findings suggest that polymorphism rs l07822 in miR-219 gene may be associated with schizophrenia in the Chinese Han population.%目的 探讨微小核糖核苷酸-219(microRNA-219,miR-219)及其靶基因钙离子/钙调蛋白依赖性蛋白激酶Ⅱγ(Ca2+/calmodulin-dependent protein kinase Ⅱ gamma,CAMK2G)多态性与精神分裂症的关系. 方法 采用TaqMan探针基因分型技术在中国汉族人群中对1041例精神分裂症患者和953例正常对照者进行miR-219基因rs107822和CAMK2G基因rs2306327的分型.利用二级结构预测软件CentroidFold预测rs107822对miR-219二级结构影响.结果 miR-219基因rs107822多态的等位基因分布在患者组与正常对照组之间差异有统计学意义(x2=7.33,P=0.007);

  12. Implementation in the reaction code system EMPIRE-2.19 of an advanced formalism for fission cross-section calculation

    International Nuclear Information System (INIS)

    Full text: The implementation in the reaction code system EMPIRE-2.19 of an advanced formalism for fission cross-section calculation has been completed. The formalism is based on the optical model for fission and can be applied for nuclei exhibiting double- or triple-humped barrier starting from sub-barrier excitation energies. The optical model for fission, initially developed to describe the resonant structure of the fission cross section at sub-barrier excitation energies due to the vibrational states in the second well of a double-humped fission barrier, was extended to light actinides by including the relations for the transmission coefficients through a complex triple-humped fission barrier. The real part of the fission barrier is parameterised as a function of the nucleus deformation by five smoothly joined parabolas. The imaginary potential is introduced only in the deformation range corresponding to the second well because the tertiary well is supposed to be shallow enough to neglect the damping of class III vibrational states. The transition states are assumed to be rotational states built on vibrational or non-collective band-heads. As the excitation energy increases, the shell effect, which causes the splitting of the outer barrier, diminishes and the outer humps lump into a single one. Therefore, in the present formalism, triple-humped barriers are associated only to the discrete transition states; the contribution of continuum to the fission coefficients is calculated considering a double-humped barrier. The parameters of the second single barrier equivalent with the outer humps are being determined from the condition of equal transmission coefficients. The saddle-point transition states in continuum are described by level densities (BCS below the critical energy and a modified version of Fermi Gas above) accounting for collective enhancements specific to the nuclear shape asymmetry at each saddle point . The neutron cross sections of 232Th in the

  13. 75 FR 32773 - Auction of 218-219 MHz Service and Phase II 220 MHz Service Licenses Scheduled for December 7...

    Science.gov (United States)

    2010-06-09

    ... or fasteners. Any envelopes must be disposed of before entering the building. Commercial overnight.... Auction 89 will offer 1,420 licenses in the 218-219 MHz Service: 716 A Block licenses and 704 B Block... Bureau proposes to divide the auction into at least two stages, each characterized by a...

  14. Immunophenotypes and Cytogenetic Alterations in 219 Cases of Diffuse Large B-cell Lymphoma%219例弥漫性大B 细胞淋巴瘤免疫表型及遗传学特征分析

    Institute of Scientific and Technical Information of China (English)

    管冰心; 潘毅; 房爱菊; 梁艳; 霍颖颖; 孙保存; 王华庆; 付凯; 孟斌

    2012-01-01

    Objective: To investigate the immunophenotypes, subtypes based on Hans algorithm, and alterations of Bcl-2 and Bcl-6 gene in diffuse large B-cell lymphoma ( DLBCL) from Chinese patients. Methods: The expression of CD10, BCL-6, MUM1, BCL-2, Ki67 and other markers were detected by immunohistochemistry in tissue microarrays of 219 DLBCL cases. Hans algorithm was applied to classify DLBCL into GCB and non-GCB subtypes. Interphase fluorescence in situ hybridization ( FISH ) was used to detect the incidence of Bcl-2 and Bcl-6 gene alterations. Other seven studies published in the last two years on DLBCL from China were collected and analyzed. Results: (1) This study: ① of 219 DLBCL cases, non-GCB subtype ( 165 cases, 75.3 % ) was significantly more common than GCB subtype ( 54 cases, 24.7 %)(P< 0.001). ② Bcl-2 gene alteration was detected in 49 cases (25.8 %), including 5 cases with the t (14 ; 18) (2.6 %) which all existed in GCB subtype, and 44 cases of Bcl-2 amplification ( 23.2 % ) which existed in GCB subtype in 4 cases ( 8.5 % ) and in non-GCB subtype in 40 cases (28.0 %){P = 0.013). ③ Bcl-6 gene rearrangement was detected in 42 cases (22.1 %), which was in GCB in 7 cases (14.9 % ) and was in non-GCB in 35 cases (24.5 % ) (P = 0.189). ④ a significant negative correlation between Bcl-2 gene amplification and Bcl-6 gene rearrangement was seen (r = - 0.179 6, P = 0.016 8). Amongst 5 cases having the t (14 ; 18) translocation, 2 cases accompanied by Bcl-6 gene rearrangement. Forty-nine cases with Bcl-2 gene alterations including translocation and amplification were all but one expressing BCL-2 protein, and there was no significant association between Bcl-6 gene rearrangement and BCL-6 protein expression ( P = 0.726 ). ⑤ there was no significant difference between nodal and extranodal DLBCLs in immunophenotypes, subtypes based on Hans algorithm, and Bcl-2 and Bcl-6 gene alterations (P = 0.462, P = 0.426 and P = 0.167). (2) Comprehensive analysis of eight

  15. Germination Response of MR 219 Rice Variety to Different Exposure Times and Periods of 2450 MHz Microwave Frequency

    Directory of Open Access Journals (Sweden)

    Daryush Talei

    2013-01-01

    Full Text Available Germination is a key process in plants' phenological cycles. Accelerating this process could lead to improvment of the seedling growth as well as the cultivation efficiency. To achieve this, the effect of microwave frequency on the germination of rice seeds was examined. The physiological feedbacks of the MR 219 rice variety in terms of seed germination rate (GR, germination percentage (GP, and mean germination time (MGT were analyzed by exposing its seeds to 2450 MHz of microwave frequency for one, four, seven, and ten hours. It was revealed that exposing the seeds to the microwave frequency for 10 hours resulted in the highest GP. This treatment led to 100% of germination after three days with a mean germination time of 2.1 days. Although the other exposure times of microwave frequency caused the moderate effects on germination with a GPa3 ranged from 93% to 98%, they failed to reduce the MGTa3. The results showed that ten-hour exposure times of microwave frequency for six days significantly facilitated and improved the germination indices (primary shoot and root length. Therefore, the technique is expected to benefit the improvement of rice seed germination considering its simplicity and efficacy in increasing the germination percentage and rate as well as the primary shoot and root length without causing any environmental toxicity.

  16. Influence of ATP-Binding Cassette Transporter 1 R219K and M883I Polymorphisms on Development of Atherosclerosis: A Meta-Analysis of 58 Studies

    OpenAIRE

    Yin, Yan-Wei; Li, Jing-Cheng; Gao, Dong; Chen, Yan-Xiu; Li, Bing-Hu; Wang, Jing-Zhou; Liu, Yun; Liao, Shao-Qiong; Zhang, Ming-Jie; Chang-yue GAO; Zhang, Li-li

    2014-01-01

    Background Numerous epidemiological studies have evaluated the associations between ATP-binding cassette transporter 1 (ABCA1) R219K (rs2230806) and M883I (rs4149313) polymorphisms and atherosclerosis (AS), but results remain controversial. The purpose of the present study is to investigate whether these two polymorphisms facilitate the susceptibility to AS using a meta-analysis. Methods PubMed, Embase, Web of Science, Medline, Cochrane database, Clinicaltrials.gov, Current Controlled Trials,...

  17. 76 FR 70336 - Airworthiness Directives; Rolls-Royce plc RB211-524G2-19; -524G2-T-19; -524G3-19; -524G3-T-19...

    Science.gov (United States)

    2011-11-14

    ... April 11, 2000 (65 FR 19477-78). Authority for This Rulemaking Title 49 of the United States Code... Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant economic impact, positive or... plc RB211-524G2-19; -524G2- T-19; -524G3-19; -524G3-T-19; 524H2-19; -524H2-T-19; -524H-36; and -...

  18. Infection of domestic dogs in peru by zoonotic bartonella species: a cross-sectional prevalence study of 219 asymptomatic dogs.

    Science.gov (United States)

    Diniz, Pedro Paulo V P; Morton, Bridget A; Tngrian, Maryam; Kachani, Malika; Barrón, Eduardo A; Gavidia, Cesar M; Gilman, Robert H; Angulo, Noelia P; Brenner, Elliott C; Lerner, Richard; Chomel, Bruno B

    2013-01-01

    Bartonella species are emerging infectious organisms transmitted by arthropods capable of causing long-lasting infection in mammalian hosts. Among over 30 species described from four continents to date, 15 are known to infect humans, with eight of these capable of infecting dogs as well. B. bacilliformis is the only species described infecting humans in Peru; however, several other Bartonella species were detected in small mammals, bats, ticks, and fleas in that country. The objective of this study was to determine the serological and/or molecular prevalence of Bartonella species in asymptomatic dogs in Peru in order to indirectly evaluate the potential for human exposure to zoonotic Bartonella species. A convenient sample of 219 healthy dogs was obtained from five cities and three villages in Peru. EDTA-blood samples were collected from 205 dogs, whereas serum samples were available from 108 dogs. The EDTA-blood samples were screened by PCR followed by nucleotide sequencing for species identification. Antibodies against B. vinsonii berkhoffii and B. rochalimae were detected by IFA (cut-off of 1∶64). Bartonella DNA was detected in 21 of the 205 dogs (10%). Fifteen dogs were infected with B. rochalimae, while six dogs were infected with B. v. berkhoffii genotype III. Seropositivity for B. rochalimae was detected in 67 dogs (62%), and for B. v. berkhoffii in 43 (40%) of the 108 dogs. Reciprocal titers ≥1∶256 for B. rochalimae were detected in 19% of dogs, and for B. v. berkhoffii in 6.5% of dogs. This study identifies for the first time a population of dogs exposed to or infected with zoonotic Bartonella species, suggesting that domestic dogs may be the natural reservoir of these zoonotic organisms. Since dogs are epidemiological sentinels, Peruvian humans may be exposed to infections with B. rochalimae or B. v. berkhoffii. PMID:24040427

  19. Infection of domestic dogs in peru by zoonotic bartonella species: a cross-sectional prevalence study of 219 asymptomatic dogs.

    Directory of Open Access Journals (Sweden)

    Pedro Paulo V P Diniz

    Full Text Available Bartonella species are emerging infectious organisms transmitted by arthropods capable of causing long-lasting infection in mammalian hosts. Among over 30 species described from four continents to date, 15 are known to infect humans, with eight of these capable of infecting dogs as well. B. bacilliformis is the only species described infecting humans in Peru; however, several other Bartonella species were detected in small mammals, bats, ticks, and fleas in that country. The objective of this study was to determine the serological and/or molecular prevalence of Bartonella species in asymptomatic dogs in Peru in order to indirectly evaluate the potential for human exposure to zoonotic Bartonella species. A convenient sample of 219 healthy dogs was obtained from five cities and three villages in Peru. EDTA-blood samples were collected from 205 dogs, whereas serum samples were available from 108 dogs. The EDTA-blood samples were screened by PCR followed by nucleotide sequencing for species identification. Antibodies against B. vinsonii berkhoffii and B. rochalimae were detected by IFA (cut-off of 1∶64. Bartonella DNA was detected in 21 of the 205 dogs (10%. Fifteen dogs were infected with B. rochalimae, while six dogs were infected with B. v. berkhoffii genotype III. Seropositivity for B. rochalimae was detected in 67 dogs (62%, and for B. v. berkhoffii in 43 (40% of the 108 dogs. Reciprocal titers ≥1∶256 for B. rochalimae were detected in 19% of dogs, and for B. v. berkhoffii in 6.5% of dogs. This study identifies for the first time a population of dogs exposed to or infected with zoonotic Bartonella species, suggesting that domestic dogs may be the natural reservoir of these zoonotic organisms. Since dogs are epidemiological sentinels, Peruvian humans may be exposed to infections with B. rochalimae or B. v. berkhoffii.

  20. Corrective Action Investigation Plan for Corrective Action Unit 219: Septic Systems and Injection Wells, Nevada Test Site, Nevada, Rev. No.: 0

    Energy Technology Data Exchange (ETDEWEB)

    David A. Strand

    2005-01-01

    The Corrective Action Investigation Plan for Corrective Action Unit 219, Septic Systems and Injection Wells, has been developed in accordance with the ''Federal Facility Agreement and Consent Order'' (1996) that was agreed to by the State of Nevada, the U.S. Department of Energy, and the U.S. Department of Defense. The purpose of the investigation is to ensure that adequate data are collected to provide sufficient and reliable information to identify, evaluate, and select technically viable corrective actions. Corrective Action Unit 219 is located in Areas 3, 16, and 23 of the Nevada Test Site, which is 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 219 is comprised of the six Corrective Action Sites (CASs) listed below: (1) 03-11-01, Steam Pipes and Asbestos Tiles; (2) 16-04-01, Septic Tanks (3); (3) 16-04-02, Distribution Box; (4) 16-04-03, Sewer Pipes; (5) 23-20-01, DNA Motor Pool Sewage and Waste System; and (6) 23-20-02, Injection Well. These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Additional information will be obtained by conducting a corrective action investigation prior to evaluating corrective action alternatives and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document.

  1. Dynamical decay process of {sup 219,} {sup 220}Ra{sup *} formed in {sup 10,} {sup 11}B+{sup 209}Bi reactions

    Energy Technology Data Exchange (ETDEWEB)

    Sawhney, G.; Sharma, M.K. [Thapar University, School of Physics and Materials Science, Punjab (India)

    2012-05-15

    The excitation functions for both the evaporation residue and fission have been calculated for {sup 10}B +{sup 209}Bi and {sup 11}B+{sup 209}Bi reactions forming compound systems {sup 219,220}Ra{sup *}, using the dynamical cluster-decay model (DCM) with effects of deformations and orientations of the nuclei included in it. In addition to this, the excitation functions for complete fusion (CF) are obtained by summing the fission cross-sections, neutron evaporation and charged particle evaporation residue cross-sections produced through the {alpha}xn and pxn (x = 2, 3, 4) emission channels for the {sup 219}Ra system at various incident centre-of-mass energies. Experimentally the CF cross-sections are suppressed and the observed suppression is attributed to the low binding energy of {sup 10,11}B which breaks up into charged fragments. The reported complete fusion (CF) and incomplete fusion (ICF) excitation functions for the {sup 219}Ra system are found to be nicely fitted by the calculations performed in the framework of DCM, without invoking a significant contribution from quasi-fission. Although DCM has been applied for a number of compound nucleus decay studies in the recent past, the same is being used here in reference to ICF and subsequent decay processes along with the CF process. Interestingly the main contribution to complete fusion cross-section comes from the fission cross-section at higher incident energies, which in DCM is found to consist of an asymmetric fission window, shown to arise due to the deformation and orientation effects of formation and decay fragments. (orig.)

  2. Correlation between R219K polymorphism in the ATP-binding cassette transporter A1 gene and ischemic stroke in young adults%ABCA1基因R219K多态性与青年缺血性脑卒中的相关性研究

    Institute of Scientific and Technical Information of China (English)

    刘竞丽; 李劲频; 汪晓玲

    2009-01-01

    Objective To investigate the correlation between the R219K polymorphism in the ATP-binding cassette transporter A1 (ABCA1) gene and arterial ischemic stroke in young adults. Methods The R219K polymorphism in the ABCA1 from 131 young patients with ischemic stroke and 135 age- and gender-matched controls was explored using polymerase chain reaction technique. The level of plasma lipids in the two groups was determined and carotid ultrasonography was employed to measure the carotid intima-media thickness (IMT). Results The frequency distributions of R219K genotype was significantly different between young patients and controls, and the patients held fewer KK genotypes than the the controls (P0.05); the level of HDL-C in the K allele carriers was significantly higher as compared with that in the non-K allele carriers (P0.05);而携带者HDL-C水平较非携带者增高,差异有统计学意义(P0.05),而携带者的颈动脉内膜、中膜厚度较非携带者明显减少,差异有统计学意义(P<0.05). 结论 ABCA1基因R219K多态性与青年缺血性脑卒中的遗传易感性相关,其中K等位基因可能对缺血性脑卒中有保护作用.推测其保护机制为通过升高血浆HDL-C水平起到减缓颈动脉内膜、中膜增厚,避免动脉粥样硬化的作用.

  3. Characterization of the K2-19 Multiple-Transiting Planetary System via High-Dispersion Spectroscopy, AO Imaging, and Transit Timing Variations

    CERN Document Server

    Narita, Norio; Fukui, Akihiko; Hori, Yasunori; Sanchis-Ojeda, Roberto; Winn, Joshua N; Ryu, Tsuguru; Kusakabe, Nobuhiko; Kudo, Tomoyuki; Onitsuka, Masahiro; Delrez, Laetitia; Gillon, Michael; Jehin, Emmanuel; McCormac, James; Holman, Matthew; Izumiura, Hideyuki; Takeda, Yoichi; Tamura, Motohide; Yanagisawa, Kenshi

    2015-01-01

    K2-19 (EPIC201505350) is a unique planetary system in which two transiting planets with radii ~ 7 $R_{Earth}$ (inner planet b) and ~ 4 $R_{Earth}$ (outer planet c) have orbits that are nearly in a 3:2 mean-motion resonance. Here, we present results of ground-based follow-up observations for the K2-19 planetary system. We have performed high-dispersion spectroscopy and high-contrast adaptive-optics imaging of the host star with the HDS and HiCIAO on the Subaru 8.2m telescope. We find that the host star is relatively old (>8 Gyr) late G-type star ($T_{eff}$ ~ 5350 K, $M_s$ ~ 0.9 $M_{Sun}$, and $R_{s}$ ~ 0.9 $R_{Sun}$). We do not find any contaminating faint objects near the host star which could be responsible for (or dilute) the transit signals. We have also conducted transit follow-up photometry for the inner planet with KeplerCam on the FLWO 1.2m telescope, TRAPPISTCAM on the TRAPPIST 0.6m telescope, and MuSCAT on the OAO 1.88m telescope. We confirm the presence of transit-timing variations, as previously re...

  4. 儿童脑萎缩的CT诊断(附219例分析)%CT diagnosis of cerebral atrophy in children

    Institute of Scientific and Technical Information of China (English)

    施益平; 郑文龙; 吴爱琴

    2008-01-01

    目的:探讨儿童脑萎缩的CT表现,提高对本病的认识.方法:回顾性分析经头颅CT检查、临床资料完整的儿童脑萎缩219例.结果:219例中,广泛性脑萎缩150例(占68.5%),局限性脑萎缩69例(占31.5%).广泛性脑萎缩CT表现为脑沟、脑池增宽、加深,脑室不同程度扩大;局限性脑萎缩表现为局部脑沟、脑池扩大、加深或脑室扩大.结论:儿童脑萎缩具有明确的CT特征表现,CT检查能提供临床可靠的影像学诊断依据.

  5. Yield Traits, Physico-chemical Characteristics and Nutritional Composition of MR219 M3 Generation and its Effect on Glycemic Index and Responses in Animal Model

    International Nuclear Information System (INIS)

    Mutation technique is a conventional breeding technique and it is very effective in improving of main crop characteristics such as yield traits, resistance to diseases and pests and nutritional qualities. In this study, MR219 seeds were treated with Carbon ion radiation (60 Gy) by AVF-Cyclotron at the Japan Atomic Energy Research Institute (JAERI), Takasaki, Japan and were planted at the Malaysian Nuclear Agency up to third mutant generation (M3). Thirty one M3 mutant lines (ML1 to ML31) were evaluated on morphological, yield and yield components, and were compared to the parental variety, MR219. Analysis of variance revealed that there was a significant difference among mutant lines in culm height, days to flowering, number of tillers, number of panicles, 1000 grain weight, total grain weight, total of dry matter, alkaline spreading value, gel consistency, amylose content, ash, crude protein, fat, dietary fibre, carbohydrate and energy. Mutant line ML21 had the best performance in majority of yield components and vegetative traits as compared to others mutant lines and parental variety. For nutritional composition, mutant lines namely ML31, ML21, ML10, ML19 were improved in crude protein content, dietary fibre and carbohydrate content. The estimation of glycemic index revealed that two mutant lines namely ML3 and ML30 can be consumed by diabetics. (author)

  6. Corrective Action Decision Document/Closure Report for Corrective Action Unit 219: Septic Systems and Injection Wells, Nevada Test Site, Nevada, Rev. No.: 0

    Energy Technology Data Exchange (ETDEWEB)

    David Strand

    2006-05-01

    This Corrective Action Decision Document/Closure Report has been prepared for Corrective Action Unit (CAU) 219, Septic Systems and Injection Wells, in Areas 3, 16, and 23 of the Nevada Test Site, Nevada, in accordance with the ''Federal Facility Agreement and Consent Order'' (1996). Corrective Action Unit 219 is comprised of the following corrective action sites (CASs): (1) 03-11-01, Steam Pipes and Asbestos Tiles; (2) 16-04-01, Septic Tanks (3); (3) 16-04-02, Distribution Box; (4) 16-04-03, Sewer Pipes; (5) 23-20-01, DNA Motor Pool Sewage and Waste System; and (6) 23-20-02, Injection Well. The purpose of this Corrective Action Decision Document/Closure Report is to provide justification and documentation supporting the recommendation for closure of CAU 219 with no further corrective action beyond the application of a use restriction at CASs 16-04-01, 16-04-02, and 16-04-03. To achieve this, corrective action investigation (CAI) activities were performed from June 20 through October 12, 2005, as set forth in the CAU 219 Corrective Action Investigation Plan and Record of Technical Change No. 1. A best management practice was implemented at CASs 16-04-01, 16-04-02, and 16-04-03, and corrective action was performed at CAS 23-20-01 between January and April 2006. In addition, a use restriction will be applied to CASs 16-04-01, 16-04-02, and 16-04-03 to provide additional protection to Nevada Test Site personnel. The purpose of the CAI was to fulfill the following data needs as defined during the data quality objective (DQO) process: (1) Determine whether contaminants of concern (COCs) are present. (2) If COCs are present, determine their nature and extent. (3) Provide sufficient information and data to complete appropriate corrective actions. The CAU 219 dataset from the investigation results was evaluated based on the data quality indicator parameters. This evaluation demonstrated the quality and acceptability of the dataset for use in fulfilling

  7. Discovery of Eclipsing Binary Central Stars in the Planetary Nebulae M 3-16, H 2-29 and M 2-19

    CERN Document Server

    Miszalski, B; Moffat, A F J; Parker, Q A; Udalski, A

    2008-01-01

    Progress in understanding the formation and evolution of planetary nebulae (PN) has been restricted by a paucity of well-determined central star masses. To address this deficiency we aim to (i) significantly increase the number of known eclipsing binary central stars of PN (CSPN), and subsequently (ii) directly obtain their masses and absolute dimensions by combining their light-curve parameters with planned radial velocity data. Using photometric data from the third phase of the Optical Gravitational Lensing Experiment (OGLE) we have searched for periodic variability in a large sample of PN towards the Galactic Bulge using Fourier and phase-dispersion minimisation techniques. Among some dozen periodically variable CSPN found, we report here on three new eclipsing binaries: M 3-16, H 2-29 and M 2-19. We present images, confirmatory spectroscopy and light-curves of the systems.

  8. Determination of optimum welding parameters in connecting high alloyed X53CrMnNiN219 and X45CrSi93 steels by friction welding

    Indian Academy of Sciences (India)

    Mehmet Uzkut; Bekir Sadik Ünlü; Mustafa Akdağ

    2011-07-01

    In this study, different welding parameters were applied to two different steels with high alloys and mechanical and metallographical investigations are performed. Thus, the optimum welding parameters were determined for these materials and working conditions. 12.30 diameter steel bars made up of 1.4871 (X53CrMnNiN219) and 1.4718 (X45CrSi93) steel were used as experimental material. The material loss increased with increase in friction and rotating pressure. No fracture at the welding region was observed and the highest fracture energy was identified in B5 group. Based on micro hardness investigation; the hardness profile reached its minimum value at the welding region.

  9. Leptin receptor isoform 219.1: an example of protein evolution by LINE-1-mediated human-specific retrotransposition of a coding SVA element.

    Science.gov (United States)

    Damert, Annette; Löwer, Johannes; Löwer, Roswitha

    2004-04-01

    Phylogenetically new insertions of repetitive sequences may contribute to genome evolution by altering the function of preexisting proteins. One example is the SVA sequence, which forms the C-terminal coding exon of the human leptin receptor isoform 219.1. Here, we report that the SVA insertion into the LEPR locus has occurred after divergence of humans and chimpanzees. The SVA element was inserted into a Hal-1/LINE element present in all monkeys and apes tested. Structural features point toward an integration event that was mediated by the L1 protein machinery acting in trans. Thus, our findings add evidence to the hypothesis that retrotransposition events are a driving force in genomic evolution and that the presence or absence of specific retroelements are one distinguishing feature that separates humans from chimpanzees.

  10. Transient climate simulations of the deglaciation 21-9 thousand years before present; PMIP4 Core experiment design and boundary conditions

    Science.gov (United States)

    Ivanovic, Ruza; Gregoire, Lauren; Kageyama, Masa; Roche, Didier; Valdes, Paul; Burke, Andrea; Drummond, Rosemarie; Peltier, W. Richard; Tarasov, Lev

    2016-04-01

    The last deglaciation, which marked the transition between the last glacial and present interglacial periods, was punctuated by a series of rapid (centennial and decadal) climate changes. Numerical climate models are useful for investigating mechanisms that underpin the events, especially now that some of the complex models can be run for multiple millennia. We have set up a Paleoclimate Modelling Intercomparison Project (PMIP) working group to coordinate efforts to run transient simulations of the last deglaciation, and to facilitate the dissemination of expertise between modellers and those engaged with reconstructing the climate of the last 21 thousand years. Here, we present the design of a coordinated Core simulation over the period 21-9 thousand years before present (ka) with time varying orbital forcing, greenhouse gases, ice sheets, and other geographical changes. A choice of two ice sheet reconstructions is given. Additional focussed simulations will also be coordinated on an ad-hoc basis by the working group, for example to investigate the effect of ice sheet and iceberg meltwater, and the uncertainty in other forcings. Some of these focussed simulations will concentrate on shorter durations around specific events to allow the more computationally expensive models to take part. Ivanovic, R. F., Gregoire, L. J., Kageyama, M., Roche, D. M., Valdes, P. J., Burke, A., Drummond, R., Peltier, W. R., and Tarasov, L.: Transient climate simulations of the deglaciation 21-9 thousand years before present; PMIP4 Core experiment design and boundary conditions, Geosci. Model Dev. Discuss., 8, 9045-9102, doi:10.5194/gmdd-8-9045-2015, 2015.

  11. 中国人内源性高甘油三酯血症患者ATP结合盒转运子A1基因R219K多态性研究%Analysis of ATP binding cassette A1 gene R219K polymorphism in patients with endogenous hypertriglyceridemia in Chinese population

    Institute of Scientific and Technical Information of China (English)

    吴银; 白怀; 刘瑞; 刘宇; 刘秉文

    2007-01-01

    目的 研究ATP结合盒转运子A1(ATP binding cassette A1, ABCA1)基因R219K多态性是否与中国人内源性高甘油三酯血症(hypertriglyceridemia, HTG)有关联,为探讨本病的分子遗传基础提供依据.方法 应用聚合酶链反应-限制性片段长度多态性分析法,对成都地区309名汉族人(200名正常人和109例内源性高甘油三酯血症患者)ABCA1基因R219K多态性位点进行分析.结果 中国人ABCA1基因R219K多态位点K等位基因频率在对照组和HTG组分别为0.472与0.436; HTG组和对照组R219K位点之间基因型和等位基因的频率差异无统计学意义.对照组和HTG组KK基因型携带者血清高密度脂蛋白胆固醇(high density lipoprotein-cholesterol, HDL-C)水平均较相应组RR基因型携带者显著升高[(1.48±0.45) mmol/L vs (1.27±0.29) mmol/L, P<0.05;(1.07±0.30) mmol/L vs (0.87±0.19) mmol/L, P<0.05];对照组RK型携带者血清甘油三酯水平较RR型携带者显著降低[(1.22±0.37) mmol/L vs (1.41±0.84) mmol/L, P<0.05],HTG组血清甘油三酯在RR、RK、KK型之间有逐渐降低的趋势[(3.82±2.02) mmol/L vs (3.42±1.67) mmol/L vs (3.33±1.43) mmol/L, P>0.05]; HTG组K等位基因携带者(RK或KK型者)总胆固醇(total cholesterol, TC)/HDL-C比值均较RR型携带者显著降低(KK vs RK vs RR:4.82±1.28 vs 5.42±1.62 vs 6.33±1.70, P<0.05).结论 ABCA1基因R219K多态性不仅与中国成都地区正常汉族人血清HDL-C、甘油三酯含量有关,而且还与内源性高甘油三酯血症患者血清HDL-C水平、TC/HDL-C比值相关联.

  12. Transient climate simulations of the deglaciation 21-9 thousand years before present (version 1) - PMIP4 Core experiment design and boundary conditions

    Science.gov (United States)

    Ivanovic, Ruza F.; Gregoire, Lauren J.; Kageyama, Masa; Roche, Didier M.; Valdes, Paul J.; Burke, Andrea; Drummond, Rosemarie; Peltier, W. Richard; Tarasov, Lev

    2016-07-01

    The last deglaciation, which marked the transition between the last glacial and present interglacial periods, was punctuated by a series of rapid (centennial and decadal) climate changes. Numerical climate models are useful for investigating mechanisms that underpin the climate change events, especially now that some of the complex models can be run for multiple millennia. We have set up a Paleoclimate Modelling Intercomparison Project (PMIP) working group to coordinate efforts to run transient simulations of the last deglaciation, and to facilitate the dissemination of expertise between modellers and those engaged with reconstructing the climate of the last 21 000 years. Here, we present the design of a coordinated Core experiment over the period 21-9 thousand years before present (ka) with time-varying orbital forcing, greenhouse gases, ice sheets and other geographical changes. A choice of two ice sheet reconstructions is given, and we make recommendations for prescribing ice meltwater (or not) in the Core experiment. Additional focussed simulations will also be coordinated on an ad hoc basis by the working group, for example to investigate more thoroughly the effect of ice meltwater on climate system evolution, and to examine the uncertainty in other forcings. Some of these focussed simulations will target shorter durations around specific events in order to understand them in more detail and allow for the more computationally expensive models to take part.

  13. Past "earthquake/tsunami" event deposits found in the Japan Trench: Results from the Sonne SO219A and Mirai MR12-E01 cruises

    Science.gov (United States)

    Ikehara, K.; Kanamatsu, T.; Strasser, M.; Fink, H.; Nagahashi, Y.; Usami, K.; Wefer, G.

    2012-12-01

    Epicenter of the 2011 off the Pacific Coast of Tohoku earthquake located under the sea floor. The large sea-floor displacement is inferred from the repeated bathymetric surveys. Because the Japan Trench is a remarkable depression near the epicenter, the gravity flows generated by the earthquake and its related phenomena might be focused in the depression (more than 7500 m in water depth) and might form the gravity flow deposits. Therefore, the Japan Trench is a target area to detect the past earthquake event deposits. To obtain the past earthquake records, we conducted two cruises; Sonne SO219A and Mirai MR12-E01 cruises. All of the cores obtained from the Japan Trench floor by two cruises showed the same lithostratigraphy. The 2011 event deposits, which were composed of thin sand at base and diatomaceous mud/ooze with multistoried upward fining grading structure, occurred at the uppermost part of the cores. Below the 2011 event deposit, at least three thick (several tens cm to a few meter thick) turbidite units were recognized. Third turbidite unit was very unique and was characterized by the calcareous nanno fossil bearing turbidite muds suggesting the transportation from upper-mid slope. A volcanic ash from the Towada volcano intercalated in hemipelagic mud between second and third turbidite units. Preliminary results on our tephra correlation using geochemical and petrographic properties suggest that the ash might be correlative to Towada-a ash, which occurred just above the Jogan tsunami deposits on the Sendai Plain. Exact correlation of the ash layer is very important to connect the deep-sea event deposits in the Japan Trench and on-shore tsunami deposits on the Sendai Plain.

  14. Evaluation of Adenosine Triphosphate-Binding Cassette Transporter A1 (ABCA1) R219K and C-Reactive Protein Gene (CRP) +1059G/C Gene Polymorphisms in Susceptibility to Coronary Heart Disease.

    Science.gov (United States)

    Li, Jing-Fang; Peng, Dian-Ying; Ling, Mei; Yin, Yong

    2016-01-01

    BACKGROUND This meta-analysis investigated the correlation of ABCA1 R219K and C-Reactive Protein Gene (CRP) +1059G/C gene polymorphisms with susceptibility to coronary heart disease (CHD). MATERIAL AND METHODS We searched PubMed, Springer link, Wiley, EBSCO, Ovid, Wanfang database, VIP database, and China National Knowledge Infrastructure (CNKI) databases to retrieve published studies by keyword. Searches were filtered using our stringent inclusion and exclusion criteria. Resultant high-quality data collected from the final selected studies were analyzed using Comprehensive Meta-analysis 2.0 software. Eleven case-control studies involving 3053 CHD patients and 3403 healthy controls met our inclusion criteria. Seven studies were conducted in Asian populations, 3 studies were done in Caucasian populations, and 1 was in an African population. RESULTS Our major finding was that ABCA1 R219K polymorphism increased susceptibility to CHD in allele model (OR=0.729, 95% CI=0.559~0.949, P=0.019) and dominant model (OR=0.698, 95% CI=0.507~0.961, P=0.027). By contrast, we were unable to find any significant association between the CRP +1059G/C polymorphism and susceptibility to CHD (allele model: OR=1.170, 95% CI=0.782~1.751, P=0.444; dominant model: OR=1.175, 95% CI=0.768~1.797, P=0.457). CONCLUSIONS This meta-analysis provides convincing evidence that polymorphism of ABCA1 R219K is associated with susceptibility to CHD while the CRP +1059G/C polymorphism appears to have no correlation with susceptibility to CHD. PMID:27560308

  15. Evaluation of Adenosine Triphosphate-Binding Cassette Transporter A1 (ABCA1) R219K and C-Reactive Protein Gene (CRP) +1059G/C Gene Polymorphisms in Susceptibility to Coronary Heart Disease.

    Science.gov (United States)

    Li, Jing-Fang; Peng, Dian-Ying; Ling, Mei; Yin, Yong

    2016-08-25

    BACKGROUND This meta-analysis investigated the correlation of ABCA1 R219K and C-Reactive Protein Gene (CRP) +1059G/C gene polymorphisms with susceptibility to coronary heart disease (CHD). MATERIAL AND METHODS We searched PubMed, Springer link, Wiley, EBSCO, Ovid, Wanfang database, VIP database, and China National Knowledge Infrastructure (CNKI) databases to retrieve published studies by keyword. Searches were filtered using our stringent inclusion and exclusion criteria. Resultant high-quality data collected from the final selected studies were analyzed using Comprehensive Meta-analysis 2.0 software. Eleven case-control studies involving 3053 CHD patients and 3403 healthy controls met our inclusion criteria. Seven studies were conducted in Asian populations, 3 studies were done in Caucasian populations, and 1 was in an African population. RESULTS Our major finding was that ABCA1 R219K polymorphism increased susceptibility to CHD in allele model (OR=0.729, 95% CI=0.559~0.949, P=0.019) and dominant model (OR=0.698, 95% CI=0.507~0.961, P=0.027). By contrast, we were unable to find any significant association between the CRP +1059G/C polymorphism and susceptibility to CHD (allele model: OR=1.170, 95% CI=0.782~1.751, P=0.444; dominant model: OR=1.175, 95% CI=0.768~1.797, P=0.457). CONCLUSIONS This meta-analysis provides convincing evidence that polymorphism of ABCA1 R219K is associated with susceptibility to CHD while the CRP +1059G/C polymorphism appears to have no correlation with susceptibility to CHD.

  16. Evaluation of Adenosine Triphosphate-Binding Cassette Transporter A1 (ABCA1) R219K and C-Reactive Protein Gene (CRP) +1059G/C Gene Polymorphisms in Susceptibility to Coronary Heart Disease

    Science.gov (United States)

    Li, Jing-Fang; Peng, Dian-Ying; Ling, Mei; Yin, Yong

    2016-01-01

    Background This meta-analysis investigated the correlation of ABCA1 R219K and CRP +1059G/C gene polymorphisms with susceptibility to coronary heart disease (CHD). Material/Methods We searched PubMed, Springer link, Wiley, EBSCO, Ovid, Wanfang database, VIP database, and China National Knowledge Infrastructure (CNKI) databases to retrieve published studies by keyword. Searches were filtered using our stringent inclusion and exclusion criteria. Resultant high-quality data collected from the final selected studies were analyzed using Comprehensive Meta-analysis 2.0 software. Eleven case-control studies involving 3053 CHD patients and 3403 healthy controls met our inclusion criteria. Seven studies were conducted in Asian populations, 3 studies were done in Caucasian populations, and 1 was in an African population. Results Our major finding was that ABCA1 R219K polymorphism increased susceptibility to CHD in allele model (OR=0.729, 95% CI=0.559~0.949, P=0.019) and dominant model (OR=0.698, 95% CI=0.507~0.961, P=0.027). By contrast, we were unable to find any significant association between the CRP +1059G/C polymorphism and susceptibility to CHD (allele model: OR=1.170, 95% CI=0.782~1.751, P=0.444; dominant model: OR=1.175, 95% CI=0.768~1.797, P=0.457). Conclusions This meta-analysis provides convincing evidence that polymorphism of ABCA1 R219K is associated with susceptibility to CHD while the CRP +1059G/C polymorphism appears to have no correlation with susceptibility to CHD. PMID:27560308

  17. Development of X80M Steel Gradeφ1 219 mm×33 mm Pipeline Steel Pipe%X80M钢级φ1219 mm×33 mm管线钢管的开发

    Institute of Scientific and Technical Information of China (English)

    张志明; 韩秀林; 姜金星; 武占芳; 刘宏博; 刘鉴卫; 赵彪

    2015-01-01

    通过对X80M钢级Φ1 219 mm×33 mm大壁厚管线钢管千吨级的试制, 总结了大壁厚管线钢管开发的技术特点. 采用超低C, 控Mn, Nb和Ti微合金化成分设计和轻压下、 热机械控制工艺(TMCP)超快冷等工艺控制措施, 国内首次批量开发出了X80M钢级33 mm大壁厚管线钢. 其母材微观组织为细小针状铁素体加弥散粒状贝氏体. 通过制管后检测, 母材及焊缝的拉伸性能、 冲击韧性和止裂性能等完全满足陕京四线工程的要求.%Through kiloton trial production for X80M Φ1 219 mm ×33 mm pipeline steel pipe, it summarized the technical characteristics of line pipe with heavy wall thickness. By the use of ultra-low C, control Mn, Nb, Ti micro-alloying composition design and soft reduction, TMCP ultrafast cold and other control measures, the X80 pipeline steel with 33 mm thickness was developed firstly in China domestic. The microstructure of base metal consists of small timber acicular ferrite and diffuse granular bainite. Through the detection, the tensile properties, impact toughness of base metal and?weld, crack arrest performance fully meet the rigorous requirements of NO.4 Shaanxi Beijing pipeline project.

  18. Results of serum drug concentration of Digoxin and adverse reactions analysis%219例地高辛血药浓度监测结果及不良反应分析

    Institute of Scientific and Technical Information of China (English)

    傅海媛

    2016-01-01

    Objective To summarize the results of serum drug concentration of digoxin in the hospital for clinical rational use . Methods Serum concentration of digoxin(219 cases)was determined by access immunoassay system and the results were statisti‐cally analyzed .Results there were 7 cases drug adverse reactions(ADR)with the serum drug concentration in the therapeutic win‐dow (0 .5‐2ng/mL) ,meanwhile ,9 cases ADR with the serum drug concentration higher than the maximun effective concentration (>2 .0ng/mL) .Conclusion Timely and effective monitoring of digoxin serum concentration should be established ,to individualize the treatment programs ,ensure the efficacy and reduce the occurrence of adverse reactions .%目的:对本院2015年1~9月地高辛血药浓度监测结果进行回顾性分析,为临床合理用药提供参考。方法采用全自动免疫分析仪对219例口服地高辛患者进行血药浓度的检测,并对监测结果及药品不良反应(ADR )进行统计、分析。结果地高辛血药浓度在0.5‐2.0ng/mL有153例(1.03±0.31ng/mL),发生7例不良反应;<0.5ng/mL有30例(0.3±0.13ng/mL);>2.0 ng/mL有36例(3.06±0.78 ng/mL),共9例不良反应。结论及时有效的监测地高辛血药浓度,实行个体化治疗,降低不良反应发生率。

  19. Potential for Cell-Transplant Therapy with Human Neuronal Precursors to Treat Neuropathic Pain in Models of PNS and CNS Injury: Comparison of hNT2.17 and hNT2.19 Cell Lines

    Directory of Open Access Journals (Sweden)

    Mary J. Eaton

    2012-01-01

    Full Text Available Effective treatment of sensory neuropathies in peripheral neuropathies and spinal cord injury (SCI is one of the most difficult problems in modern clinical practice. Cell therapy to release antinociceptive agents near the injured spinal cord is a logical next step in the development of treatment modalities. But few clinical trials, especially for chronic pain, have tested the potential of transplant of cells to treat chronic pain. Cell lines derived from the human neuronal NT2 cell line parentage, the hNT2.17 and hNT2.19 lines, which synthesize and release the neurotransmitters gamma-aminobutyric acid (GABA and serotonin (5HT, respectively, have been used to evaluate the potential of cell-based release of antinociceptive agents near the lumbar dorsal (horn spinal sensory cell centers to relieve neuropathic pain after PNS (partial nerve and diabetes-related injury and CNS (spinal cord injury damage in rat models. Both cell lines transplants potently and permanently reverse behavioral hypersensitivity without inducing tumors or other complications after grafting. Functioning as cellular minipumps for antinociception, human neuronal precursors, like these NT2-derived cell lines, would likely provide a useful adjuvant or replacement for current pharmacological treatments for neuropathic pain.

  20. 37 CFR 1.219 - Early publication.

    Science.gov (United States)

    2010-07-01

    ... COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES National Processing Provisions Publication of... copy of the application in compliance with the Office electronic filing system requirements pursuant...

  1. 33 CFR 136.219 - Authorized claimants.

    Science.gov (United States)

    2010-07-01

    ..., without regard to the ownership or management of the resources. (b) A claim for loss of profits or impairment of earning capacity due to loss of subsistence use of natural resources must be included as...

  2. 12 CFR 219.3 - Cost reimbursement.

    Science.gov (United States)

    2010-01-01

    ... that the financial institution use programming or other higher level technical services of a computer... of extracting electronically stored records, based on computer time and necessary supplies; however, personnel time for computer searches may be paid for at the rates set for computer support...

  3. 22 CFR 219.103 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... following body systems: Neurological; musculoskeletal; special sense organs; respiratory, including speech organs; cardiovascular; reproductive; digestive; genitourinary; hemic and lymphatic; skin; and endocrine... impairments, cerebral palsy, epilepsy, muscular dystrophy, multiple sclerosis, cancer, heart disease,...

  4. 36 CFR 219.1 - Purpose.

    Science.gov (United States)

    2010-07-01

    ... 1948, as amended by the Federal Water Pollution Control Act Amendments of 1977 and the Water Quality..., forage, timber, wildlife and fish, biological diversity, productive soils, clean air and water, and minerals. They also afford intangible benefits such as beauty, inspiration, and wonder. (2) To assure...

  5. 49 CFR 21.9 - Compliance information.

    Science.gov (United States)

    2010-10-01

    ... should have available for the Secretary racial and ethnic data showing the extent to which members of... discrimination assured them by the Act and this part. ... participants. Each recipient shall make available to participants, beneficiaries, and other interested...

  6. 6 CFR 21.9 - Compliance information.

    Science.gov (United States)

    2010-01-01

    ... its obligations under this part. In general, recipients should have available for the Secretary racial... necessary to apprise such persons of the protections against discrimination assured them by the Act and this... available to participants, beneficiaries, and other interested persons such information regarding...

  7. 48 CFR 219.1005 - Applicability.

    Science.gov (United States)

    2010-10-01

    ... OF DEFENSE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Small Business Competitiveness... construction projects or military family housing projects are exempt from the Small Business Competitiveness... prohibited under the Small Business Competitiveness Demonstration Program, when an ESB set-aside is...

  8. 48 CFR 219.1007 - Procedures.

    Science.gov (United States)

    2010-10-01

    ... OF DEFENSE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Small Business Competitiveness... document, alternative means may be used to identify the contract as an award under the Small Business Competitiveness Demonstration Program. (b)(1) The Director, Small Business Programs, Office of the Under...

  9. 36 CFR 219.36 - Definitions.

    Science.gov (United States)

    2010-07-01

    ..., road construction, timber harvest, and the introduction of exotic species. Diversity of plant and... aquatic and terrestrial habitats, roads and other structural developments, human uses, and invasive and... cycling, water movement, disturbance, and succession. Ecosystem structure: The biological and...

  10. Association between ε2/3/4, Promoter Polymorphism (−491A/T, −427T/C, and −219T/G at the Apolipoprotein E Gene, and Mental Retardation in Children from an Iodine Deficiency Area, China

    Directory of Open Access Journals (Sweden)

    Jun Li

    2014-01-01

    Full Text Available Background. Several common single-nucleotide polymorphisms (SNPs at apolipoprotein E (ApoE have been linked with late onset sporadic Alzheimer’s disease and declining normative cognitive ability in elder people, but we are unclear about their relationship with cognition in children. Results. We studied -491A/T, -427T/C, and -219G/T promoter polymorphisms and ε2/ε3/ε4 at ApoE among children with mental retardation (MR, n=130, borderline MR (n=124, and controls (n=334 from an iodine deficiency area in China. The allelic and genotypic distribution of individual locus did not significantly differ among three groups with Mantel-Haenszel χ2 test (P>0.05. However, frequencies of haplotype of -491A/-427T/-219T/ε4 were distributed as MR > borderline MR > controls (P uncorrected = 0.004, indicating that the presence of this haplotype may increase the risk of disease. Conclusions. In this large population-based study in children, we did not find any significant association between single locus of the four common ApoE polymorphisms (-491A/T, -427T/C, -219T/G, and ε2/3/4 and MR or borderline MR. However, we found that the presence of ATTε4 haplotype was associated with an increased risk of MR and borderline MR. Our present work may help enlarge our knowledge of the cognitive role of ApoE across the lifespan and the mechanisms of human cognition.

  11. ATP结合盒转运子1R219K基因多态性与阿尔茨海默病相关性研究%Research on association between polymorphism of ATP-binding cassette transporter A1 and Alzheimer's disease

    Institute of Scientific and Technical Information of China (English)

    王娟; 陈卫蓉; 肖志杰

    2013-01-01

    Objective To assess the effect of single-nucleotide polymorphisms (SNPs) in the cholesterol-related genes ABCA1 exon R219K variation on the risk of AD and cognitive function.Methods Using case-control study,a total of sporadic 104 AD patients and 104 individuals above 60 years without cognitive impairment from a population of Chinese Han nationality in Changsha area were studied to determine the polymorphisms of ABCA1 R219K.Adopt SPSS 13.0 for statistical analysis.Results There were significant differences in the frequencies of three genotypes (RR、RK and KK) between the AD patients and controls (x2 =8.777,P =0.012).The frequency of KK genotype in AD group is obviously lower than that of controls (x2 =5.261,P =0.022).The frequency of KK+RK genotype in AD patients was 54.8%,was significantly lower than that of controls (70.2%,P =0.022).There was significantly higher levels of HDL-C,apoA-I and cognitive scores in the carriers of KK genotype and K allele (P < 0.05).There was significantly higher levels of MMSE and WMS scores in the carriers of K K genotype and K allele (P < 0.05).Further in accordance with memory types including long-term memory,short-term memory,transient memory,compared with RR genotype,the scores of short-term memory,transient memory of RK,KK and RK + KK genotypes were higher (P < 0.05),but there was no significant difference in the score of long-term memory (P > 0.05).Multifactor logistic regression analysis showed that carrying K allele was a single protective factor for AD.Conclusions The polymorphism of ABCA1R219K is associated with AD.Carrying K allele may play a positive role in serum lipids and cognition,and produce a protective effect on risk of AD.%目的 探讨胆固醇相关基因ABCA1外显子R219K遗传变异对阿尔茨海默病(AD)发病风险及认知功能的影响.方法 采用病例对照研究方法测定湖南长沙地区汉族人群104例散发性AD患者以及104名60岁以上认知功能正常者的ABCA1R219K

  12. Evaluation of a Wet Chemistry Method for Isolation of Cyclotron Produced [211At]Astatine

    Directory of Open Access Journals (Sweden)

    Shigeki Watanabe

    2013-09-01

    Full Text Available A “wet chemistry” approach for isolation of 211At from an irradiated bismuth target is described. The approach involves five steps: (1 dissolution of bismuth target in conc. HNO3; (2 removal of the HNO3 by distillation; (3 dissolution of residue in 8 M HCl; (4 extraction of 211At from 8 M HCl into DIPE; and (5 extraction of 211At from DIPE into NaOH. Results from 55 “optimized” 211At isolation runs gave recovery yields of approximately 78% after decay and attenuation corrections. An attenuation-corrected average of 26 ± 3 mCi in the target provided isolated (actual yields of 16 ± 3 mCi of 211At. A sixth step, used for purification of 211At from trace metals, was evaluated in seven runs. In those runs, isolated 211At was distilled under reductive conditions to provide an average 71 ± 8% recovery. RadioHPLC analyses of the isolated 211At solutions, both initial and after distillation, were obtained to examine the 211At species present. The primary species of 211At present was astatide, but astatate and unidentified species were also observed. Studies to determine the effect of bismuth attenuation on 211At were conducted to estimate an attenuation factor (~1.33 for adjustment of 211At readings in the bismuth target.

  13. Production of Astatine-211 at the Duke University Medical Center for its regional distribution

    Energy Technology Data Exchange (ETDEWEB)

    Zalutsky, Michael [Duke University Medical Center, Durham, NC (United States)

    2016-01-01

    Systemic targeted radiation therapy and radioimmunotherapy continue to be important tools in the treatment of certain cancers. Because of their high energy and short path length, alpha particle emitters such as 211At are more effective than either external beam x- ray or in vivo beta radiation in delivering potentially curative doses of radiation. The limited clinical trials that have been conducted to date have yielded encouraging responses in some patients, e.g., malignant brain tumors. In order to escalate the additional necessary research and development in radiochemistry, radiobiology and efficacy evaluation of alpha particle radiotherapeutics, it is universally agreed that access to an affordable, reliable supply of 211At is warranted. In conjunction with the Department of Energy's intent to enhance stable and radioactive isotope availability for research applications, it is the primary objective of this project to improve 211At production and purification capabilities at Duke so that this radionuclide can be supplied to researchers at other institutions throughout the US.The most widely used 211At production method involves the α,2n reaction on Bismuth using a cyclotron with beams ≤ 28 MeV. Yields can be enhanced with use of an internal target that allows for a higher alpha fluence plus efficient heat dissipation in the target. Both of these items are in place at Duke; however, in order to support production for multi-institutional use, irradiation campaigns in excess of 50 µAp and four hours duration will be needed. Further, post-irradiation processing equipment is lacking that will enable the distribution process. Financial support is sought for i) a shielded, ventilated processing/containment hood; ii) development of a post-irradiation target retrieval system; iii) fabrication of a 211At distillation and recovery module and iv) a performance review and, where needed, an enhancement of seven major subsystems that comprise the CS-30 Cyclotron. With these modifications in place, routine production of ≥200 mCi of At-211 should be readily achievable, given our methodological development of At-211 target preparation, internal target irradiation and dry distillation to recover the radionuclide.

  14. Final Report for grant entitled "Production of Astatine-211 for U.S. Investigators"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, Daniel Scott

    2012-12-12

    Alpha-particle emitting radionuclides hold great promise in the therapy of cancer, but few alpha-emitters are available to investigators to evaluate. Of the alpha-emitters that have properties amenable for use in humans, 211At is of particular interest as it does not have alpha-emitting daughter radionuclides. Thus, there is a high interest in having a source of 211At for sale to investigators in the US. Production of 211At is accomplished on a cyclotron using an alpha-particle beam irradiation of bismuth metal. Unfortunately, there are few cyclotrons available that can produce an alpha particle beam for that production. The University of Washington has a cyclotron, one of three in the U.S., that is currently producing 211At. In the proposed studies, the things necessary for production and shipment of 211At to other investigators will be put into place at UW. Of major importance is the efficient production and isolation of 211At in a form that can be readily used by other investigators. In the studies, production of 211At on the UW cyclotron will be optimized by determining the best beam energy and the highest beam current to maximize 211At production. As it would be very difficult for most investigators to isolate the 211At from the irradiated target, the 211At-isolation process will be optimized and automated to more safely and efficiently obtain the 211At for shipment. Additional tasks to make the 211At available for distribution include obtaining appropriate shipping vials and containers, putting into place the requisite standard operating procedures for Radiation Safety compliance at the levels of 211At activity to be produced / shipped, and working with the Department of Energy, Isotope Development and Production for Research and Applications Program, to take orders, make shipments and be reimbursed for costs of production and shipment.

  15. Investigation on the Full Thickness Repair Welding Process of X80Mφ1 219 mm×18.4 mm SAWH Pipe%X80M级准1219 mm×18.4 mm螺旋埋弧焊管全壁厚补焊工艺研究

    Institute of Scientific and Technical Information of China (English)

    杨军; 苟世峰; 符利兵; 陈长青

    2015-01-01

    利用夏比冲击、显微硬度和拉伸试验对6种焊材在相同补焊工艺下的全壁厚刨透补焊焊缝进行了性能对比研究,筛选出焊缝性能较优的对应补焊焊材。并以此焊材作为X80M级φ1219 mm ×18.4 mm螺旋埋弧焊管焊缝缺陷手工修补用专用焊材,进行了不同补焊工艺参数的全壁厚刨透补焊试验,并对补焊焊缝进行低温冲击试验,通过比较确定出X80M级φ1219 mm×18.4 mm螺旋埋弧焊管全壁厚刨透补焊工艺方案。结果表明,上海焊接器材厂生产的SH J557焊条用于X80M级φ1219 mm×18.4 mm螺旋埋弧焊管焊缝缺陷全壁厚刨透手工修补更为合适,各项性能指标更高;确定的补焊工艺参数合理可行,确保了补焊焊缝的质量和钢管的批量化生产。%The properties of full thickness repair welding seam that generated by 6 kinds of welding material under the same repair welding condition were comparatively investigated by V-notch Charpy impact toughness test, micro-hardness test and tensile test, and selected out the repair welding material matching with better weld performance. Taking the selected welding material as special welding material for manual repairing the weld defect in φ1 219 mm ×18.4 mm X80M SAWH pipe, the full thickness repair welding tests for the different welding process parameter were conducted, and the low temperature impact test for repair weld was carried out. Finally, it determined the repair welding process for φ1 219 mm×18.4 mm X80M SAWH pipe. The results indicated that the SHJ557 welding electrode produced by Shanghai Welding Equipment Factory is more suitable for the above repair welding process of φ1 219 mm ×18.4 mm X80M SAWH pipe, the various performance indexes are higher; the determined repair welding process parameters are reasonable, it ensures the quality of repair weld and the mass production of steel pipe.

  16. 36 CFR 219.17 - Interaction with private landowners.

    Science.gov (United States)

    2010-07-01

    ... AGRICULTURE PLANNING National Forest System Land and Resource Management Planning Collaborative Planning for... activities; (c) Potential conditions and activities on the adjacent lands that may affect management...

  17. 36 CFR 219.13 - Coordination among Federal agencies.

    Science.gov (United States)

    2010-07-01

    ... AGRICULTURE PLANNING National Forest System Land and Resource Management Planning Collaborative Planning for... proposed actions; (b) For the streamlined coordination of Federal agency policies, resource management... management plans....

  18. 36 CFR 219.4 - Identification and consideration of issues.

    Science.gov (United States)

    2010-07-01

    ... AGRICULTURE PLANNING National Forest System Land and Resource Management Planning The Framework for Planning... interested in or affected by National Forest System management; Presidential, Departmental, and...

  19. 36 CFR 219.24 - Science consistency evaluations.

    Science.gov (United States)

    2010-07-01

    ... AGRICULTURE PLANNING National Forest System Land and Resource Management Planning The Contribution of Science... available science. (b) The science advisory board is responsible for organizing and conducting a...

  20. Dicty_cDB: VSF219 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 0.009 2 BU042820 |BU042820.1 PP_LEa0014B11f Peach developing fruit mesocarp Prunus persica cDNA clone PP_LE...a0014B11f, mRNA sequence. 52 0.010 1 BU041769 |BU041769.1 PP_LEa0010G24f Peach developing...32.1 PP_LEa0019F12f Peach developing fruit mesocarp Prunus persica cDNA clone PP_LEa0019F12f, mRNA sequence.

  1. 49 CFR 219.903 - Retention of drug testing records.

    Science.gov (United States)

    2010-10-01

    .... (4) Records related to employee training: (i) Materials on drug abuse awareness, including a copy of... the following records for a minimum of five years: (i) A summary record of each covered employee's... verifying the existence of a medical explanation of the inability of a covered employee to provide...

  2. Dicty_cDB: VFA219 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available N BD092935 |BD092935.1 Methods and compositions for synthesis of long chain poly...unsaturated fatty acids in plants. 1213 0.0 3 BD082645 |BD082645.1 Methods and compositions for synthesis of... long chain polyunsaturated fatty acids. 1213 0.0 3 BD082630 |BD082630.1 Methods and compositions for synthe

  3. Dicty_cDB: SSD219 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available LYLYYT SGEKKDIPFVPKFAPAFNPKTAGSHSGTKGAKGVVKSKHG*ik*******ii*yits*st fqsysnsthyhyhhiqnlkpkkkkkkkkkkklynnc--- ...YLYYT SGEKKDIPFVPKFAPAFNPKTAGSHSGTKGAKGVVKSKHG*ik*******ii*yits*st fqsysnsthyhyhhiqnlkpkkkkkkkkkkklynn

  4. Dicty_cDB: SHH219 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available cleotide Sequence of the Haemophilus influenzae Rd Genome,Fragments Thereof, and Uses Thereof. 44 9e-05 2 U3.... 44 1e-04 2 BD425742 |BD425742.1 The Nucleotide Sequence of the Haemophilus influenzae Rd Genome,Fragments Thereof, and Uses

  5. 36 CFR 219.18 - Role of advisory committees.

    Science.gov (United States)

    2010-07-01

    ... PLANNING National Forest System Land and Resource Management Planning Collaborative Planning for... variety of public purposes, particularly those groups organized to develop landscape goals (§...

  6. 48 CFR 52.219-9 - Small business subcontracting plan.

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    2010-10-01

    ... identification of the types planned for subcontracting to— (i) Small business concerns; (ii) Veteran-owned small... excessively long, reasonable effort shall be made to give all such small business concerns an opportunity to... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Small...

  7. 20 CFR 725.219 - Duration of entitlement; child.

    Science.gov (United States)

    2010-04-01

    ...; (3) The child attains age 18; and (i) Is not a student (as defined in § 725.209(b)) during any part of the month in which the child attains age 18; and (ii) Is not under a disability (as defined in § 725.209(a)(2)(ii)) at that time; (4) If the child's entitlement beyond age 18 is based on his or...

  8. 36 CFR 219.21 - Social and economic sustainability.

    Science.gov (United States)

    2010-07-01

    ... consistent with the requirements of ecological sustainability, the estimated cost of providing them, and the... economic benefits to communities through natural resource restoration strategies; (iv) Other social or... opportunities, wage levels, local tax bases, federal revenue sharing, the ability to support...

  9. 48 CFR 53.219 - Small Business Programs.

    Science.gov (United States)

    2010-10-01

    ... for use in reporting small business (including Alaska Native Corporations and Indian tribes), veteran... disadvantaged business (including Alaska Native Corporations and Indian tribes) and women-owned small business... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Small Business...

  10. 48 CFR 52.219-22 - Small Disadvantaged Business Status.

    Science.gov (United States)

    2010-10-01

    ... Joint Ventures. The offeror represents, as part of its offer, that it is a joint venture that complies... Business Administration or a Private Certifier in accordance with 13 CFR part 124, subpart B. For joint... in the joint venture....

  11. 29 CFR 1910.219 - Mechanical power-transmission apparatus.

    Science.gov (United States)

    2010-07-01

    ...) (ii) (2) Wood guards. (i) Wood guards may be used in the woodworking and chemical industries, in industries where the presence of fumes or where manufacturing conditions would cause the rapid deterioration... belt and pulley guard. (3) For the Textile Industry, because of the presence of excessive deposits...

  12. Dicty_cDB: VFB219 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ( AY785660 |pid:none) Trypanosoma cruzi strain Dm 28 c c... 405 e-111 AY785657_1( AY785657 |pid:none) Trypanosoma cruzi strain Colomb...ian... 405 e-111 protein update 2009. 6.17 PSORT psg: 0.

  13. 34 CFR 685.219 - Public Service Loan Forgiveness Program.

    Science.gov (United States)

    2010-07-01

    ... organization that is publicly funded and whose principal activities pertain to crime prevention, control or reduction of crime, or the enforcement of criminal law. Military service, for uniformed members of the U.S... library or other school-based services; and (ii) Is not a business organized for profit, a labor union,...

  14. 36 CFR 219.25 - Science advisory boards.

    Science.gov (United States)

    2010-07-01

    ... Science advisory boards. (a) National science advisory board. The Forest Service Deputy Chief for Research... social sciences. (b) Regional science advisory boards. Based upon needs identified by Regional Forester(s... including, but not limited to, the physical, biological, economic, and social sciences. Regional...

  15. 48 CFR 52.219-1 - Small Business Program Representations.

    Science.gov (United States)

    2010-10-01

    ... check the category in which its ownership falls: __ Black American. __ Hispanic American. __ Native American (American Indians, Eskimos, Aleuts, or Native Hawaiians). __ Asian-Pacific American (persons with... provision: Small Business Program Representations (MAY 2004) (a)(1) The North American...

  16. Dicty_cDB: SFD219 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 90353.1 sae68c10.y1 Gm-c1064 Glycine max cDNA clone GENOME SYSTEMS CLONE ID: Gm-c1064-3212 5' similar to TR:...049 Glycine max cDNA clone GENOME SYSTEMS CLONE ID: Gm-c1049-1199 5' similar to T...c1007 Glycine max cDNA clone GENOME SYSTEMS CLONE ID: Gm-c1007-2626 5' similar to TR:O65744 O65744 GDP DISSO...TION INHIBITOR. ;, mRNA sequence. 62 4e-08 2 BI315670 |BI315670.1 saf75f12.y1 Gm-c1078 Glycine max cDNA clone GENOME SYSTEMS...sequence. 62 1e-07 2 AI437629 |AI437629.1 sa37e09.y1 Gm-c1004 Glycine max cDNA clone GENOME SYSTEMS

  17. 30 CFR 219.410 - What does this subpart contain?

    Science.gov (United States)

    2010-07-01

    ..., Louisiana, Mississippi, and Texas (collectively identified as the Gulf producing States); to eligible coastal political subdivisions within those States; and to the Land and Water Conservation Fund. Shared... coastal protection, including conservation, coastal restoration, hurricane protection, and...

  18. 47 CFR 90.219 - Use of signal boosters.

    Science.gov (United States)

    2010-10-01

    ... to operate radio systems in the frequency bands above 150 MHz may employ signal boosters at fixed... fill in only weak signal areas and cannot extend the system's normal signal coverage area. (b) Class A... effective radiated power (ERP) of the unit to a maximum of 5 watts under all conditions. Class B...

  19. Research and Development of X80 Grade SAWH Pipe with Size of φ1 219 mm×22.0 mm%X80级准1219 mm×22.0 mm螺旋埋弧焊管的研制

    Institute of Scientific and Technical Information of China (English)

    陈楠; 孙志刚; 李建一; 孙少卿; 祁超; 王海生

    2015-01-01

    The X80 grade hot-rolled coil with large wall thickness was manufactured by using the technology of low carbon, high manganese, Nb-Mo compound additive, micro alloying, clean smelting, controlled rolling and controlled cooling. Through research on steel pipe low tress forming technology, welding speed optimization, double rack ultrasonic testing technology, the X80 grade SAWH pipe with size of φ1 219 mm×22.0 mm was developed. The property tests were conducted in accordance with relevant technical standard. The test results showed that the transverse yield strength of pipe body is 580~670 MPa;the tensile strength is 665~770 MPa;the tensile strength of weld seam is 695~760 MPa;the hardness of welded joint is less than 268 HV10 Under-10℃,the average impact energy of pipe body in transverse is higher than 319 J;the average impact energy of HAZ is higher than 183 J, and the average impact energy of weld seam is higher than 137 J. Under 0℃,the DWTT shear area of pipe body in transverse is 100%. The pipe is with good mechanical properties and weldability.%采用低C高Mn及Nb-Mo复合添加、微合金化设计和洁净化冶炼、控轧控冷工艺制造的X80级大壁厚热轧卷板,通过钢管低应力成型、焊接速度优选以及双探架超声波检测等技术,成功开发出X80级准1219 mm×22.0 mm螺旋埋弧焊管。按标准要求对该产品进行了组批力学性能试验,试验结果显示:钢管管体横向屈服强度为580~670 MPa,抗拉强度为665~770 MPa,焊缝抗拉强度为695~760 MPa;焊接接头最大硬度小于268 HV10;-10℃管体横向平均冲击功大于319 J,热影响区平均冲击功大于183 J,焊缝平均冲击功大于137 J;0℃管体横向DWTT剪切面积均为100%。试验结果表明,钢管整体具有良好的力学性能和可焊性。

  20. An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE,CERN

    OpenAIRE

    Rothe, Sebastian

    2012-01-01

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spec...

  1. Low background counting of 222Rn, 220Rn and 219Rn with electrostatic counters

    Science.gov (United States)

    Mong, Brian; EXO-200 Collaboration; nEXO Collaboration

    2014-09-01

    The radon counting technique based on electrostatic precipitation of progenies in gas followed by alpha spectroscopy has been applied to support the material selection programs of low background, neutrino and dark matter experiments with emphasis on EXO. An array of 8 counters operated by Laurentian University at SNOLAB and the Waste Isolation Pilot Plant have reached the sensitivity of 10 atoms/day in the uranium, thorium and actinium chains. Hardware improvements are underway to further increase the capacity and sensitivity in support of nEXO. The radon counting technique based on electrostatic precipitation of progenies in gas followed by alpha spectroscopy has been applied to support the material selection programs of low background, neutrino and dark matter experiments with emphasis on EXO. An array of 8 counters operated by Laurentian University at SNOLAB and the Waste Isolation Pilot Plant have reached the sensitivity of 10 atoms/day in the uranium, thorium and actinium chains. Hardware improvements are underway to further increase the capacity and sensitivity in support of nEXO. Supported by NSERC Project Grants ``Search for Double Beta Decay with EXO.''

  2. 29 CFR 778.219 - Pay for foregoing holidays and vacations.

    Science.gov (United States)

    2010-07-01

    ... for working. Suppose an employee who is entitled to such a paid idle holiday or paid vacation foregoes... received $90 pay for working on the holiday—double time for 9 hours of work. Thus, clearly, all of the pay..., certain payments made to an employee for periods during which he performs no work because of a holiday...

  3. 28 CFR 2.219 - Maximum terms of imprisonment and supervised release.

    Science.gov (United States)

    2010-07-01

    ... schedule I or II drugs other than above (e.g., marijuana/hashish), or schedule III drugs 3 years 2 years... II drugs other than above (e.g., marijuana, hashish, methamphetamine), or schedule III or IV drugs 3.... If schedule I or II drugs other than above (e.g., marijuana, hashish), or schedule III or IV drugs...

  4. 7 CFR 2.19 - Under Secretary for Food, Nutrition, and Consumer Services.

    Science.gov (United States)

    2010-01-01

    .... (vii) Approve the designation of agency Consumer Affairs Contacts. (3) Related to human nutrition... 7 Agriculture 1 2010-01-01 2010-01-01 false Under Secretary for Food, Nutrition, and Consumer..., Nutrition, and Consumer Services. (a) The following delegations of authority are made by the Secretary...

  5. 49 CFR 219.201 - Events for which testing is required.

    Science.gov (United States)

    2010-10-01

    ... conveyance at a rail/highway grade crossing. No test may be required in the case of an accident/incident the... physical damage be specifically described. (2) A railroad must not require an employee to provide blood...

  6. 36 CFR 219.16 - Relationships with interested individuals and organizations.

    Science.gov (United States)

    2010-07-01

    ..., DEPARTMENT OF AGRICULTURE PLANNING National Forest System Land and Resource Management Planning Collaborative... individuals and organizations to work collaboratively with one another to improve understanding and...

  7. 48 CFR 1052.219-70 - SF 294 and SF 295 Reporting.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false SF 294 and SF 295... SF 294 and SF 295 Reporting. Per DTAR 1019.708-70(a), insert the following clause: SF 294 and SF 295... Small Business Subcontracting Plan” in Section I and the contract schedule, SF 294 and SF 295...

  8. 20 CFR 219.55 - Evidence of school attendance for child age 18.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Evidence of school attendance for child age... school attendance for child age 18. The child will be asked to submit (on a form furnished by the Board... statement from an official of the school verifying that the child is attending school full-time. The...

  9. Codon 219 polymorphism of PRNP in healthy caucasians and Creutzfeldt-Jakob disease patients

    Energy Technology Data Exchange (ETDEWEB)

    Petraroli, R.; Pocchiari, M. [Instituto Superiore di Sanita, Rome (Italy)

    1996-04-01

    A number of point and insert mutations of the PrP gene (PRNP) have been linked to familial Creutzfeldt-Jakob disease (CJD) and Gerstmann-Straussler-Scheinker disease (GSS). Moreover, the methionine/valine homozygosity at the polymorphic codon 129 of PRNP may cause a predisposition to sporadic and iatrogenic CJD or may control the age at onset of familial cases carrying either the 144-bp insertion or codon 178, codon 198, and codon 210 pathogenic mutations in PRNP. In addition, the association of methionine or valine at codon 129 and the point mutation at codon 178 on the same allele seem to play an important role in determining either fatal familial insomnia or CJD. However, it is noteworthy that a relationship between codon 129 polymorphism and accelerated pathogenesis (early age at onset or shorter duration of the disease) has not been seen in familial CJD patients with codon 200 mutation or in GSS patients with codon 102 mutation, arguing that other, as yet unidentified, gene products or environmental factors, or both, may influence the clinical expression of these diseases. 17 refs.

  10. 14 CFR 125.219 - Oxygen for medical use by passengers.

    Science.gov (United States)

    2010-01-01

    ... title 49 CFR parts 171, 172, and 173, except § 173.24(a)(1); (ii) When owned by the certificate holder... the form of a compressed gas as defined in title 49 CFR 173.300(a)— (i) When owned by the certificate... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Oxygen for medical use by passengers....

  11. 20 CFR 219.21 - Types of evidence to prove age.

    Science.gov (United States)

    2010-04-01

    ...) Selective service registration record. (9) Census record. (10) School record. (11) Vaccination record. (12... registration of birth made before age 5. (b) Other evidence of age. If an individual cannot obtain...

  12. 14 CFR 120.219 - Handling of test results, record retention, and confidentiality.

    Science.gov (United States)

    2010-01-01

    ... requirement. In addition to the records required to be maintained under 49 CFR part 40, employers must..., you must use the Management Information System (MIS) form and instructions as required by 49 CFR part 40 (at 49 CFR 40.26 and appendix H to 49 CFR part 40). You may also use the electronic version of...

  13. Morphological and biochemical responses of Oryza sativa L. (cultivar MR219) to ion beam irradiation

    Institute of Scientific and Technical Information of China (English)

    Anna Pick Kiong LING; Ying Chian UNG; Sobri HUSSEIN; Abdul Rahim HARUN; Atsushi TANAKA; Hase YOSHIHIRO

    2013-01-01

    Objective:Heavy ion beam, which has emerged as a new mutagen in the mutation breeding of crops and ornamental plants, is expected to result in the induction of novel mutations. This study investigates the morphological and biochemical responses of Oryza sativa toward different doses of carbon ion beam irradiation. Methods: In this study, the dry seeds of O. sativa were irradiated at 0, 20, 40, 60, 80, 100, and 120 Gy, fol owed by in-vitro germination under control ed conditions. Morphological and biochemical studies were conducted to investigate the morphological and physiological responses of O. sativa towards ion beam irradiation. Results: The study demonstrated that low doses (10 Gy) of ion beam have a stimulating effect on the height, root length, and fresh weight of the plantlets but not on the number of leaves. Meanwhile, doses higher than 10 Gy caused reductions in all the morphological parameters studied as compared to the control samples. The highest total soluble protein content [(2.11±0.47) mg/g FW] was observed in plantlets irradiated at 20 Gy. All irradiated plantlets were found to have 0.85%to 58.32%higher specific activity of peroxidase as compared to the control samples. The present study also revealed that low doses of ion beam (10 and 20 Gy) had negligible effect on the total chlorophyl content of O. sativa plantlets while 40 Gy had a stimulating effect on the chlorophyll content. Plantlets irradiated between 40 to 120 Gy were shown to be 0.38%to 9.98%higher in total soluble nitrogen content which, however, was not significantly different from the control samples. Conclusions:Carbon ion beam irradiation administered at low to moderate doses of 10 to 40 Gy may induce O. sativa mutants with superior characteristics.

  14. 20 CFR 219.34 - When evidence that a marriage has ended is required.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false When evidence that a marriage has ended is... a marriage has ended is required. Evidence of how a previous marriage ended may be required to determine whether a later marriage is valid. If a widow or widower remarried after the employee's death...

  15. Calibration of ground-based lidar instrument WLS7-219

    DEFF Research Database (Denmark)

    Gómez Arranz, Paula; Wagner, Rozenn

    This report presents the result of the lidar calibration performed for the given WLS7 Windcube at DTU’s test site for large wind turbine at Høvsøre, Denmark. Calibration is here understood as the establishment of a relation between the reference wind speed measurements with measurement uncertaint...

  16. Calibration of ground-based Lidar instrument WLS7-219

    DEFF Research Database (Denmark)

    Yordanova, Ginka; Gómez Arranz, Paula

    This report presents the result of the lidar calibration performed for the given WLS7 Windcube at DTU’s test site for large wind turbines at Høvsøre, Denmark. Calibration is here understood as the establishment of a relation between the reference wind speed measurements with measurement uncertain...

  17. SUBTASK 2.19 – OPERATIONAL FLEXIBILITY OF CO2 TRANSPORT AND STORAGE

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, Melanie; Schlasner, Steven; Sorensen, James; Hamling, John

    2014-12-31

    Carbon dioxide (CO2) is produced in large quantities during electricity generation and by industrial processes. These CO2 streams vary in terms of both composition and mass flow rate, sometimes substantially. The impact of a varying CO2 stream on pipeline and storage operation is not fully understood in terms of either operability or infrastructure robustness. This study was performed to summarize basic background from the literature on the topic of operational flexibility of CO2 transport and storage, but the primary focus was on compiling real-world lessons learned about flexible operation of CO2 pipelines and storage from both large-scale field demonstrations and commercial operating experience. Modeling and pilot-scale results of research in this area were included to illustrate some of the questions that exist relative to operation of carbon capture and storage (CCS) projects with variable CO2 streams. It is hoped that this report’s real-world findings provide readers with useful information on the topic of transport and storage of variable CO2 streams. The real-world results were obtained from two sources. The first source consisted of five full-scale, commercial transport–storage projects: Sleipner, Snøhvit, In Salah, Weyburn, and Illinois Basin–Decatur. These scenarios were reviewed to determine the information that is available about CO2 stream variability/intermittency on these demonstration-scale projects. The five projects all experienced mass flow variability or an interruption in flow. In each case, pipeline and/or injection engineers were able to accommodate any issues that arose. Significant variability in composition has not been an issue at these five sites. The second source of real- world results was telephone interviews conducted with experts in CO2 pipeline transport, injection, and storage during which commercial anecdotal information was acquired to augment that found during the literature search of the five full-scale projects. The experts represented a range of disciplines and hailed from North America and Europe. Major findings of the study are that compression and transport of CO2 for enhanced oil recovery (EOR) purposes in the United States has shown that impurities are not likely to cause transport problems if CO2 stream composition standards are maintained and pressures are kept at 10.3 MPa or higher. Cyclic, or otherwise intermittent, CO2 supplies historically have not impacted in-field distribution pipeline networks, wellbore integrity, or reservoir conditions. The U.S. EOR industry has demonstrated that it is possible to adapt to variability and intermittency in CO2 supply through flexible operation of the pipeline and geologic storage facility. This CO2 transport and injection experience represents knowledge that can be applied in future CCS projects. A number of gaps in knowledge were identified that may benefit from future research and development, further enhancing the possibility for widespread application of CCS. This project was funded through the Energy & Environmental Research Center–U.S. Department of Energy Joint Program on Research and Development for Fossil Energy-Related Resources Cooperative Agreement No. DE-FC26-08NT43291. Nonfederal funding was provided by the IEA Greenhouse Gas R&D Programme.

  18. 32 CFR 219.119 - Research undertaken without the intention of involving human subjects.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Research undertaken without the intention of... undertaken without the intention of involving human subjects. In the event research is undertaken without the intention of involving human subjects, but it is later proposed to involve human subjects in the...

  19. 48 CFR 52.219-18 - Notification of Competition Limited to Eligible 8(a) Concerns.

    Science.gov (United States)

    2010-10-01

    ... the acquisition is for a product in a class for which the Small Business Administration has determined... Eligible 8(a) Concerns (JUN 2003) (a) Offers are solicited only from small business concerns expressly certified by the Small Business Administration (SBA) for participation in the SBA's 8(a) Program and...

  20. 48 CFR 252.219-7004 - Small business subcontracting plan (test program).

    Science.gov (United States)

    2010-10-01

    ... Subcontracting Plan (Test Program) (AUG 2008) (a) Definition. Subcontract, as used in this clause, means any... Contractor shall submit Standard Form (SF) 295, Summary Subcontract Report, in accordance with the... completed to include semi-annual cumulative— (i) Small business, small disadvantaged business, and...

  1. Yeast Interacting Proteins Database: YPL031C, YPL219W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available ting the cellular response to nutrient levels and environmental conditions and progression through the cell ...e cellular response to nutrient levels and environmental conditions and progression through the cell cycle R

  2. 32 CFR 219.101 - To what does this policy apply?

    Science.gov (United States)

    2010-07-01

    ... benefits or services under those programs. (6) Taste and food quality evaluation and consumer acceptance... agency head may adopt such procedural modifications as may be appropriate from an administrative... which are designed to study, evaluate, or otherwise examine: (i) Public benefit or service programs;...

  3. La Desercion Escolar en los Niveles de Sexto y Noveno Grado: Una Comparacion Entre Zonas Rurales y Urbanas. Boletin 219 (The Educational Desertion in the 6th and 9th Grades: A Comparison Between Rural and Urban Zones. Bulletin 219).

    Science.gov (United States)

    Lopez, Maria I. Hernandez; And Others

    In 1962 and again in 1965, a group of sixth and ninth grade students in selected schools in four Puerto Rican communities were interviewed to investigate the factors influencing students' decision to withdraw from school before completing twelfth grade and to identify some characteristics of dropouts. Of 616 students interviewed in 1962, 20.9% of…

  4. ПC-219车辆轮对轴承圈过盈量检测仪%Interference tester for the bearing rings on wheelsets of ПC - 219 railcars

    Institute of Scientific and Technical Information of China (English)

    胥金荣

    2006-01-01

      与铁路行车安全紧密相关的问题之一,就是缺少用于批量检测轴承内圈在轮对车轴上套装可靠过盈量的仪器.目前所使用的常规方法,其可靠性较低.因为它是以套装之前测量轴承圈和轮对车轴的直径为依据的,并没有考虑到轴承圈的加热和与车轴的机械连接,这些随机工艺过程中的许多因素对套装质量将产生较大的影响.

  5. Lithium-vanadium advanced blanket development. ITER final report on U.S. contribution: Task T219/T220

    Energy Technology Data Exchange (ETDEWEB)

    Smith, D.L.; Mattas, R.F. [comps.

    1997-07-01

    The objective of this task is to develop the required data base and demonstrate the performance of a liquid lithium-vanadium advanced blanket design. The task has two main activities related to vanadium structural material and liquid lithium system developments. The vanadium alloy development activity included four subtasks: (1.1) baseline mechanical properties of non irradiated base metal and weld metal joints; (1.2) compatibility with liquid lithium; (1.3) material irradiation tests; and (1.4) development of material manufacturing and joining methods. The lithium blanket technology activity included four subtasks: (2.1) electrical insulation development and testing for liquid metal systems; (2.2) MHD pressure drop and heat transfer study for self-cooled liquid metal systems; (2.3) chemistry of liquid lithium; and (2.4) design, fabrication and testing of ITER relevant size blanket mockups. A summary of the progress and results obtained during the period 1995 and 1996 in each of the subtask areas is presented in this report.

  6. 30 CFR 219.416 - How will the qualified OCS revenues be allocated to coastal political subdivisions within the...

    Science.gov (United States)

    2010-07-01

    ... political subdivisions in the proportion that each coastal political subdivision's miles of coastline bears to the number of miles of coastline of all coastal political subdivisions in the producing State. Except that, for the State of Louisiana, proxy coastline lengths for coastal political...

  7. 30 CFR 219.417 - How will MMS disburse qualified OCS revenues to the coastal political subdivisions if, during any...

    Science.gov (United States)

    2010-07-01

    ... political subdivision's miles of coastline bears to the number of miles of coastline of all coastal political subdivisions in the State. Except that, for the State of Louisiana, proxy coastline lengths for coastal political subdivisions without a coastline will be considered to be 1/3 the average length of...

  8. 30 CFR 219.414 - How will MMS determine each Gulf producing State's share of the qualified OCS revenues?

    Science.gov (United States)

    2010-07-01

    ... the geographic centers of each applicable leased tract to each Gulf producing State's coastline. (b... on the State's coastline that are closest to the geographic centers of the applicable leased...

  9. 75 FR 12968 - Airworthiness Directives; Pratt & Whitney JT8D-209, -217, -217C, and -219 Turbofan Engines

    Science.gov (United States)

    2010-03-18

    ... (62 FR 4902). ADDRESSES: You can get the service information identified in this AD from Pratt... proposed AD in the Federal Register on December 21, 2009 (74 FR 67831). That action proposed to require...'' under DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and (3) Will not have...

  10. 75 FR 38052 - Airworthiness Directives; Pratt & Whitney JT8D-209, -217, -217A, -217C, and -219 Series Turbofan...

    Science.gov (United States)

    2010-07-01

    ... April 11, 2000 (65 FR 19477-78). Examining the AD Docket You may examine the AD docket on the Internet... 39 by superseding AD 2005-02- 03, Amendment 39-13948 (70 FR 3867, January 27, 2005). That AD requires... Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Would not have a...

  11. 76 FR 16526 - Airworthiness Directives; Pratt & Whitney JT8D-209, -217, -217A, -217C, and -219 Series Turbofan...

    Science.gov (United States)

    2011-03-24

    ...We are superseding an existing airworthiness directive (AD) for the products listed above. That AD currently requires initial and repetitive torque inspections of the 3rd stage and 4th stage low- pressure turbine (LPT) blades for shroud notch wear and replacement of the blade if wear limits are exceeded. That AD also requires replacing LPT-to-exhaust case bolts and nuts with bolts and nuts......

  12. 75 FR 50945 - Airworthiness Directives; Pratt & Whitney JT8D-209, -217, -217A, -217C, and -219 Turbofan Engines

    Science.gov (United States)

    2010-08-18

    ... complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477-78...-02, Amendment 39-14242 (70 FR 52004, September 1, 2005), to require revisions to the TLS of the... Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Would not have a...

  13. 75 FR 25844 - Class Deviation From FAR 52.219-7, Notice of Partial Small Business Set-Aside

    Science.gov (United States)

    2010-05-10

    ... portion at a price higher than its offer price under the non-set-aside portion. The proposed revisions are... DOCUMENT. I237.06 NOTICE OF PARTIAL SMALL BUSINESS SET-ASIDE (DEVIATION) (DESC) (a) DEFINITION. Small... negotiated as to price and an evaluation will be made as though there were no set-aside. (4) For the...

  14. 75 FR 53533 - Procedures for the Handling of Retaliation Complaints Under Section 219 of the Consumer Product...

    Science.gov (United States)

    2010-08-31

    ...: take affirmative action to abate the violation; reinstate the complainant to his or her former position together with the compensation of that position (including back pay) and restore the terms, conditions, and... finds that the complaint is frivolous or has been brought in bad faith. Within 60 days of the...

  15. Jürgen Jaspers: De klank van de stad. Stedelijke meertaligheid en interculturele communicatie (red.). Leuven, ACCO, 2009. 219 blz.

    NARCIS (Netherlands)

    Nortier, J.M.

    2010-01-01

    De klank van de stad is geschreven naar aanleiding van een congres over hetzelfde thema, stedelijke meertaligheid (maart 2008, Antwerpen). De auteurs waren in meerderheid sprekers bij het congres die hun presentaties in soms wat gewijzigde vorm hebben opgeschreven. Iedereen die wel eens te maken hee

  16. 48 CFR 52.219-21 - Small Business Size Representation for Targeted Industry Categories Under the Small Business...

    Science.gov (United States)

    2010-10-01

    ... Representation for Targeted Industry Categories Under the Small Business Competitiveness Demonstration Program... Competitiveness Demonstration Program. As prescribed in 19.1008(c), insert the following provision: Small Business Size Representation for Targeted Industry Categories Under the Small Business...

  17. 50 CFR 226.219 - Critical habitat for the Southern Distinct Population Segment of North American Green Sturgeon...

    Science.gov (United States)

    2010-10-01

    ....); Richardson Bay, unnamed tributary (37°54′2″ N./122°31′36″ W.); San Antonio Creek, unnamed tributary (38°9′45... areas and bays and estuaries are delineated by the COLREGS lines (33 CFR 80). Critical habitat in... following coastal bays and estuaries in California, Oregon, and Washington: (i) San Francisco Bay, San...

  18. 32 CFR 219.103 - Assuring compliance with this policy-research conducted or supported by any Federal Department or...

    Science.gov (United States)

    2010-07-01

    ..., declaration, or statement of ethical principles, or a statement formulated by the institution itself. This... principles governing the institution in the discharge of its responsibilities for protecting the rights and... institution. (Approved by the Office of Management and Budget under Control Number 0990-0260)...

  19. Compound list: simvastatin [Open TG-GATEs

    Lifescience Database Archive (English)

    Full Text Available simvastatin SST 00117 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/simv...astatin.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/simv...astatin.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/simv...archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/simvastatin.Rat.in_vivo.Liver.Repeat.zip ...

  20. Integrated plant safety assessment: systematic evaluation program. Oyster Creek nuclear generating station. GPU Nuclear Corporation and Jersey Central Power and Light Company. Docket No. 50-219

    International Nuclear Information System (INIS)

    The Systematic Evaluation Program was initiated in February 1978 by the US Nuclear Regulatory Commission to review the designs of older operating nuclear reactor plants to reconfirm and document their safety. The review provides (1) an assessment of how these plants compare with current licensing safety requirements relating to selected issues, (2) a basis for deciding on how these differences should be resolved in an integrated plant review, and (3) a documented evaluation of plant safety. This report documents the review of the Oyster Creek Nuclear Generating Station (located in Ocean County, New Jersey), one of ten plants reviewed under Phase II of this program, and indicates how 137 topics selected for review under Phase I of the program were addressed. Equipment and procedural changes have been identified as a result of the review. It is expected that this report will be one of the bases in considering the issuance of a full-term operating license in place of the existing provisional operating license

  1. P2-19: The Effect of item Repetition on Item-Context Association Depends on the Prior Exposure of Items

    Directory of Open Access Journals (Sweden)

    Hongmi Lee

    2012-10-01

    Full Text Available Previous studies have reported conflicting findings on whether item repetition has beneficial or detrimental effects on source memory. To reconcile such contradictions, we investigated whether the degree of pre-exposure of items can be a potential modulating factor. The experimental procedures spanned two consecutive days. On Day 1, participants were exposed to a set of unfamiliar faces. On Day 2, the same faces presented on the previous day were used again in half of the participants, whereas novel faces were used for the other half. Day 2 procedures consisted of three successive phases: item repetition, source association, and source memory test. In the item repetition phase, half of the face stimuli were repeatedly presented while participants were making male/female judgments. During the source association phase, both the repeated and the unrepeated faces appeared in one of the four locations on the screen. Finally, participants were tested on the location in which a given face was presented during the previous phase and reported the confidence of their memory. Source memory accuracy was measured as the percentage of correct non-guess trials. As results, we found a significant interaction between prior exposure and repetition. Repetition impaired source memory when the items had been pre-exposed on Day 1, while it led to greater accuracy in novel ones. These results show that pre-experimental exposure can modulate the effects of repetition on associative binding between an item and its contextual information, suggesting that pre-existing representation and novelty signal interact to form new episodic memory.

  2. Proceedings of US/Japan workshop, Q219 on high heat flux components and plasma surface interactions for next fusion devices

    Energy Technology Data Exchange (ETDEWEB)

    Ulrickson, M.A.; Stevens, P.L.; Hino, T.; Hirohata, Y. [eds.

    1996-12-01

    This report contains the viewgraphs from the proceedings of US/Japan Workshop on High Heat Flux Components and Plasma Surface Interactions for Next Fusion Devices. Some of the general topics covered by this report are: PFC/PSI in tokamak and helical devices; development of high heat flux components; PSIS and plasma facing materials;tritium; and material damage.

  3. Proceedings of US/Japan workshop, Q219 on high heat flux components and plasma surface interactions for next fusion devices

    International Nuclear Information System (INIS)

    This report contains the viewgraphs from the proceedings of US/Japan Workshop on High Heat Flux Components and Plasma Surface Interactions for Next Fusion Devices. Some of the general topics covered by this report are: PFC/PSI in tokamak and helical devices; development of high heat flux components; PSIS and plasma facing materials;tritium; and material damage

  4. SU-E-J-219: A Dixon Based Pseudo-CT Generation Method for MR-Only Radiotherapy Treatment Planning of the Pelvis and Head and Neck

    International Nuclear Information System (INIS)

    Purpose: To develop an image processing method for MRI-based generation of electron density maps, known as pseudo-CT (pCT), without usage of model- or atlas-based segmentation, and to evaluate the method in the pelvic and head-neck region against CT. Methods: CT and MRI scans were obtained from the pelvic region of four patients in supine position using a flat table top only for CT. Stratified CT maps were generated by classifying each voxel based on HU ranges into one of four classes: air, adipose tissue, soft tissue or bone.A hierarchical region-selective algorithm, based on automatic thresholding and clustering, was used to classify tissues from MR Dixon reconstructed fat, In-Phase (IP) and Opposed-Phase (OP) images. First, a body mask was obtained by thresholding the IP image. Subsequently, an automatic threshold on the Dixon fat image differentiated soft and adipose tissue. K-means clustering on IP and OP images resulted in a mask that, via a connected neighborhood analysis, allowing the user to select the components corresponding to bone structures.The pCT was estimated through assignment of bulk HU to the tissue classes. Bone-only Digital Reconstructed Radiographs (DRR) were generated as well. The pCT images were rigidly registered to the stratified CT to allow a volumetric and voxelwise comparison. Moreover, pCTs were also calculated within the head-neck region in two volunteers using the same pipeline. Results: The volumetric comparison resulted in differences <1% for each tissue class. A voxelwise comparison showed a good classification, ranging from 64% to 98%. The primary misclassified classes were adipose/soft tissue and bone/soft tissue. As the patients have been imaged on different table tops, part of the misclassification error can be explained by misregistration. Conclusion: The proposed approach does not rely on an anatomy model providing the flexibility to successfully generate the pCT in two different body sites. This research is founded by ZonMw IMDI Programme, project name: “RASOR sharp: MRI based radiotherapy planning using a single MRI sequence”, project number: 10-104003010

  5. 77 FR 62315 - Holiday CVS, L.L.C., d/b/a CVS/Pharmacy Nos. 219 and 5195; Decision and Order

    Science.gov (United States)

    2012-10-12

    ... controlled substance prescriptions. See Ralph J. Bertolino, d/b/a Ralph J. Bertolino Pharmacy, 55 FR 4729... East Main Street Pharmacy, 75 FR 66,149, 66,158 (2010) (noting expert's testimony that `` t is well... abused controlled substances. Ralph J. Bertolino, d/b/a/Ralph J. Bertolino Pharmacy, 55 FR 4,729,...

  6. 77 FR 62346 - Holiday CVS, L.L.C., d/b/a CVS/Pharmacy Nos. 219 and 5195; Denial of Request for Redactions

    Science.gov (United States)

    2012-10-12

    ... protection. Resp. Req. at 4-5 (citing Penick Corp., 68 FR 6947 (2003); Johnson Matthey, 67 FR 39041 (2002... determination to continue to protect the information from disclosure in the final order. See Penick, 68 FR at 6948; Johnson Matthey, 67 FR at 39041. Moreover, each of these cases involved a challenge to...

  7. Investigations of the in Planta Expression of Active Cellobiohydrolase I: Cooperative Research and Development Final Report, CRADA Number CRD-07-219

    Energy Technology Data Exchange (ETDEWEB)

    Himmel, M.

    2011-02-01

    It was the purpose of this project to determine if cellulases produced in transgenic plants could effectively be utilized in the production of ethanol and other feedstock chemicals from lignocellulosic substrates.

  8. Synthesis and Characterization of Unsymmetrical (10,11), (26,27)- Dimide-2,19-disulfonic acid Phthalocyanine Zinc Dipotassium Salt

    Institute of Scientific and Technical Information of China (English)

    PENG Yi-Ru; LIN Zhi-Peng; HUANG Feng-Hua; LIU Li-Zheng

    2003-01-01

    @@ Metallophthalocyanines (MPcs) are generally obtained by templated reaction using metal salts and aromatic ortho-dinitrile or dicarboxylic anhyrides. [1] Published routes for preparing amphiphilic phthalocyanine mostly involve one of two methods: "in a plot" reaction and in situ reaction, [2] i. e. condensation of two different substituted precursors in appropriate statistical rate. The first method unavoidably leads to a product with much more complicated mixture, so that it needs tedious separation. While the second method in which the synthesis of amphiphilic phthalocyine is performed by mixed condensation of two types of precursors (hydrophic and lipophilic) which differ substantially in their physical properties and reactivities require arduously selection of optimal reaction conditions.

  9. Improving Lowland Rice (O. sativa L. cv. MR219) Plant Growth Variables, Nutrients Uptake, and Nutrients Recovery Using Crude Humic Substances.

    Science.gov (United States)

    Palanivell, Perumal; Ahmed, Osumanu Haruna; Ab Majid, Nik Muhamad; Jalloh, Mohamadu Boyie; Susilawati, Kasim

    2015-01-01

    High cation exchange capacity and organic matter content of crude humic substances from compost could be exploited to reduce ammonia loss from urea and to as well improve rice growth and soil chemical properties for efficient nutrients utilization in lowland rice cultivation. Close-dynamic air flow system was used to determine the effects of crude humic substances on ammonia volatilization. A pot experiment was conducted to determine the effects of crude humic substances on rice plant growth, nutrients uptake, nutrients recovery, and soil chemical properties using an acid soil mixed with three rates of crude humic substances (20, 40, and 60 g pot(-1)). Standard procedures were used to evaluate rice plant dry matter production, nutrients uptake, nutrients recovery, and soil chemical properties. Application of crude humic substances increased ammonia volatilization. However, the lowest rate of crude humic substances (20 g pot(-1)) significantly improved total dry matter, nutrients uptake, nutrients recovery, and soil nutrients availability compared with crude humic substances (40 and 60 g pot(-1)) and the normal fertilization. Apart from improving growth of rice plants, crude humic substances can be used to ameliorate acid soils in rice cultivation. The findings of this study are being validated in our ongoing field trials.

  10. Improving Lowland Rice (O. sativa L. cv. MR219 Plant Growth Variables, Nutrients Uptake, and Nutrients Recovery Using Crude Humic Substances

    Directory of Open Access Journals (Sweden)

    Perumal Palanivell

    2015-01-01

    Full Text Available High cation exchange capacity and organic matter content of crude humic substances from compost could be exploited to reduce ammonia loss from urea and to as well improve rice growth and soil chemical properties for efficient nutrients utilization in lowland rice cultivation. Close-dynamic air flow system was used to determine the effects of crude humic substances on ammonia volatilization. A pot experiment was conducted to determine the effects of crude humic substances on rice plant growth, nutrients uptake, nutrients recovery, and soil chemical properties using an acid soil mixed with three rates of crude humic substances (20, 40, and 60 g pot−1. Standard procedures were used to evaluate rice plant dry matter production, nutrients uptake, nutrients recovery, and soil chemical properties. Application of crude humic substances increased ammonia volatilization. However, the lowest rate of crude humic substances (20 g pot−1 significantly improved total dry matter, nutrients uptake, nutrients recovery, and soil nutrients availability compared with crude humic substances (40 and 60 g pot−1 and the normal fertilization. Apart from improving growth of rice plants, crude humic substances can be used to ameliorate acid soils in rice cultivation. The findings of this study are being validated in our ongoing field trials.

  11. SU-E-J-219: A Dixon Based Pseudo-CT Generation Method for MR-Only Radiotherapy Treatment Planning of the Pelvis and Head and Neck

    Energy Technology Data Exchange (ETDEWEB)

    Maspero, M.; Meijer, G.J.; Lagendijk, J.J.W.; Berg, C.A.T. van den [Department of Radiotherapy, UMC Utrecht (Netherlands); Seevinck, P.R.; Viergever, M.A. [Image Science Institute, UMC Utrecht (Netherlands)

    2015-06-15

    Purpose: To develop an image processing method for MRI-based generation of electron density maps, known as pseudo-CT (pCT), without usage of model- or atlas-based segmentation, and to evaluate the method in the pelvic and head-neck region against CT. Methods: CT and MRI scans were obtained from the pelvic region of four patients in supine position using a flat table top only for CT. Stratified CT maps were generated by classifying each voxel based on HU ranges into one of four classes: air, adipose tissue, soft tissue or bone.A hierarchical region-selective algorithm, based on automatic thresholding and clustering, was used to classify tissues from MR Dixon reconstructed fat, In-Phase (IP) and Opposed-Phase (OP) images. First, a body mask was obtained by thresholding the IP image. Subsequently, an automatic threshold on the Dixon fat image differentiated soft and adipose tissue. K-means clustering on IP and OP images resulted in a mask that, via a connected neighborhood analysis, allowing the user to select the components corresponding to bone structures.The pCT was estimated through assignment of bulk HU to the tissue classes. Bone-only Digital Reconstructed Radiographs (DRR) were generated as well. The pCT images were rigidly registered to the stratified CT to allow a volumetric and voxelwise comparison. Moreover, pCTs were also calculated within the head-neck region in two volunteers using the same pipeline. Results: The volumetric comparison resulted in differences <1% for each tissue class. A voxelwise comparison showed a good classification, ranging from 64% to 98%. The primary misclassified classes were adipose/soft tissue and bone/soft tissue. As the patients have been imaged on different table tops, part of the misclassification error can be explained by misregistration. Conclusion: The proposed approach does not rely on an anatomy model providing the flexibility to successfully generate the pCT in two different body sites. This research is founded by ZonMw IMDI Programme, project name: “RASOR sharp: MRI based radiotherapy planning using a single MRI sequence”, project number: 10-104003010.

  12. Reliability and measurement error of frontal and horizontal 3D spinal motion parameters in 219 patients with chronic low back pain

    DEFF Research Database (Denmark)

    Harsted, Steen; Mieritz, Rune M; Bronfort, Gert;

    2016-01-01

    were evaluated using intraclass correlation coefficients ICC(1,1) and Bland-Altman limits of agreement (LOAs). RESULTS: The reliability analysis based on the whole study sample showed ICC(1,1) coefficients varying between 0.68 and 0.73 for the frontal plane and 0.33 and 0.49 for the horizontal plane....... Relatively wide LOAs were observed for all parameters. Reliability measures in patient subgroups ICC(1,1) ranged between 0.55 and 0.81 for the frontal plane and 0.28 and 0.69 for the horizontal plane. Greater ICC(1,1) coefficients and smaller LOA were observed when patients were examined by the same examiner...

  13. Safety Evaluation Report related to the full-term operating license for Oyster Creek Nuclear Generating Station (Docket No. 50-219)

    International Nuclear Information System (INIS)

    The Safety Evaluation Report for the full-term operating license application filed by GPU Nuclear Corporation and Jersey Central Power ampersand Light Company for the Oyster Creek Nuclear Generating Station has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The facility is located in Ocean County, New Jersey. The staff concludes that the facility can continue to be operated without endangering the health and safety of the public. 1 figs., 5 tabs

  14. SU-E-J-219: Quantitative Evaluation of Motion Effects On Accuracy of Image-Guided Radiotherapy with Fiducial Markers Using CT Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Ali, I; Oyewale, S; Ahmad, S; Algan, O [University of Oklahoma Health Sciences, Oklahoma City, OK (United States); Alsbou, N [Department of Electrical and Computer Engineering, Ada, OH (United States)

    2014-06-01

    Purpose: To investigate quantitatively patient motion effects on the localization accuracy of image-guided radiation with fiducial markers using axial CT (ACT), helical CT (HCT) and cone-beam CT (CBCT) using modeling and experimental phantom studies. Methods: Markers with different lengths (2.5 mm, 5 mm, 10 mm, and 20 mm) were inserted in a mobile thorax phantom which was imaged using ACT, HCT and CBCT. The phantom moved with sinusoidal motion with amplitudes ranging 0–20 mm and a frequency of 15 cycles-per-minute. Three parameters that include: apparent marker lengths, center position and distance between the centers of the markers were measured in the different CT images of the mobile phantom. A motion mathematical model was derived to predict the variations in the previous three parameters and their dependence on the motion in the different imaging modalities. Results: In CBCT, the measured marker lengths increased linearly with increase in motion amplitude. For example, the apparent length of the 10 mm marker was about 20 mm when phantom moved with amplitude of 5 mm. Although the markers have elongated, the center position and the distance between markers remained at the same position for different motion amplitudes in CBCT. These parameters were not affected by motion frequency and phase in CBCT. In HCT and ACT, the measured marker length, center and distance between markers varied irregularly with motion parameters. The apparent lengths of the markers varied with inverse of the phantom velocity which depends on motion frequency and phase. Similarly the center position and distance between markers varied inversely with phantom speed. Conclusion: Motion may lead to variations in maker length, center position and distance between markers using CT imaging. These effects should be considered in patient setup using image-guided radiation therapy based on fiducial markers matching using 2D-radiographs or volumetric CT imaging.

  15. 中药贯序疗法治疗肝癌围肝动脉栓塞化疗期患者219例临床观察%Clinical Investigation on Chinese Herb Sequential Therapy for 219 Cases of Liver Cancer with Embolism of Peripheral Hepatic Artery at Chemotherapeutic Stage

    Institute of Scientific and Technical Information of China (English)

    苏小康; 周伟生; 徐发彬; 王芳军; 赵天清; 林宜胜; 温凤媚; 崔学教

    2004-01-01

    目的:探讨中药贯序治疗在肝癌围肝动脉栓塞术(TACE)中的作用.方法:收集438例中晚期肝癌行TACE患者,分为肝郁脾虚型(14%)、气滞血瘀型(42%)、湿热蕴结型(29%)、肝肾阴虚型(15%)4型,随症加减中药治疗.配对观察TACE术中碘油用量,术后肝储备功能、影像学资料、毒副反应和免疫功能的差别.结果:在中药贯序支持治疗下TACE术后患者肝功能CHILD-Pugh和ICGR15损害明显减轻(P<0.05),免疫抑制减轻,对抗发热、胃肠道反应、黄疸、腹水等毒副反应(P<0.01),也可以抑制脾脏肿大,但是对术中碘油用量、肿瘤大小和包膜形成影响不大(P>0.05).结论:围TACE中药贯序支持治疗可以减轻肝功能损害,对抗术后毒副反应,减轻免疫抑制,但对影像学资料和术中碘油用量影响不大.

  16. SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995

    Energy Technology Data Exchange (ETDEWEB)

    Jaszczak, R.J.

    1995-12-01

    Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed tomography (SPECT) quantification of iodine 123 and astatine 211; and the development and evaluation of SPECT pinhole imaging for low and medium energy photons.

  17. Shelf-life of ɛ-lysyl-3-(trimethylstannyl)benzamide immunoconjugates, precursors for 211At labeling of antibodies

    DEFF Research Database (Denmark)

    Aneheim, Emma; Halleröd, Jenny; Albertsson, Per;

    2015-01-01

    Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it comes to the treatment of occult disseminated cancer. Preclinical research has proven effective, and patient studies have been initiated based on these results. However, a lack of production capacity...

  18. 10 CFR Appendix B to Part 20 - Annual Limits on Intake (ALIs) and Derived Air Concentrations (DACs) of Radionuclides for...

    Science.gov (United States)

    2010-01-01

    .... Actinium Ac 89 Aluminum Al 13 Americium Am 95 Antimony Sb 51 Argon Ar 18 Arsenic As 33 Astatine At 85... Curium Cm 96 Dysprosium Dy 66 Einsteinium Es 99 Erbium Er 68 Europium Eu 63 Fermium Fm 100 Fluorine F...

  19. SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995

    International Nuclear Information System (INIS)

    Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed tomography (SPECT) quantification of iodine 123 and astatine 211; and the development and evaluation of SPECT pinhole imaging for low and medium energy photons

  20. 75 FR 3221 - Ruby Pipeline, L.L.C.; Notice of Availability of the Final Environmental Impact Statement for the...

    Science.gov (United States)

    2010-01-20

    ... 219, Section 219.35(b) (published in the Federal Register at 65 FR 67514 ; see also 36 CFR 219 Interpretive Rule published at 66 FR 1864 ) and found at http://www.fs.fed.us/appeals/appeals_related.php#app_work . The objection procedures found at 36 CFR 219.32 (published in the Federal Register at 65...

  1. Application of solar energy to the supply of industrial process hot water: preliminary design and performance report. Volume I. Technical report. Aerotherm report TR-76-219. [For can washing at Campbell Soup Plant in Sacramento

    Energy Technology Data Exchange (ETDEWEB)

    None

    1976-10-14

    The design and performance of a solar hot water system for can washing at the Campbell Soup Plant in Sacramento, California, are presented. The collector field is located on the roof of the finished products warehouse of the Campbell Soup Sacramento plant. Water is supplied from a 3.8 cm (1/sup 1///sub 2/ in.) supply line which is located directly below an existing roof access hatch. A supply pipe will be brought up through that hatch. The water flow will then be split into two manifold lines which supply the dual rows of flat plate collectors. The preheated water from the flat plates is then passed into six sets of parallel connected concentrators. Each set consist of eight 1.83 x 3.05 m (6 x 10 foot) modules connected in series. The water from these units is gathered in a 3.8 cm (1/sup 1///sub 2/ in.) insulated pipe which transports it to the storage tank. This pipe will be attached to an existing pipe run until it reaches the can washing building. From there the pipe will follow the can washing building around to the storage tank. The storage tank is a 75,200 1 (20,000 gal) steel tank which is coated internally with a USDA approved phenolic liner. The outside of the tank is insulated. A 2.2 kw (3 hp) motor is used to pump the stored water for the tank into the can washing line. Detail drawings and descriptions of the collector field, installation, piping, controls, data acquisition equipment, and roof structure are included. Furthermore, a program schedule with equipment and manpower costs for successfully completing Phase II of this contract is included. Also included is an organization chart of the Phase II program personnel. (WHK)

  2. Hyperspectral surface materials map of quadrangles 3666 and 3766, Balkh (219), Mazar-e Sharif (220), Qarqin (213), and Hazara Toghai (214) quadrangles, Afghanistan, showing carbonates, phyllosilicates, sulfates, altered minerals, and other materials

    Science.gov (United States)

    Kokaly, Raymond F.; King, Trude V.V.; Hoefen, Todd M.; Livo, Keith E.; Johnson, Michaela R.; Giles, Stuart A.

    2013-01-01

    This map shows the spatial distribution of selected carbonates, phyllosilicates, sulfates, altered minerals, and other materials derived from analysis of airborne HyMap™ imaging spectrometer (hyperspectral) data of Afghanistan collected in late 2007. The map is one in a series of U.S. Geological Survey/Afghanistan Geological Survey quadrangle maps covering Afghanistan. Flown at an altitude of 50,000 feet (15,240 meters (m)), the HyMap™ imaging spectrometer measured reflected sunlight in 128 channels, covering wavelengths between 0.4 and 2.5 μm. The data were georeferenced, atmospherically corrected and converted to apparent surface reflectance, empirically adjusted using ground-based reflectance measurements, and combined into a mosaic with 23-m pixel spacing. Variations in water vapor and dust content of the atmosphere, in solar angle, and in surface elevation complicated correction; therefore, some classification differences may be present between adjacent flight lines. The reflectance spectrum of each pixel of HyMap™ imaging spectrometer data was compared to the reference materials in a spectral library of minerals, vegetation, water, and other materials. Minerals occurring abundantly at the surface and those having unique spectral features were easily detected and discriminated, while minerals having slightly different compositions but similar spectral features were less easily discriminated; thus, some map classes consist of several minerals having similar spectra, such as “Epidote or chlorite.” A designation of “Not classified” was assigned to the pixel when there was no match with reference spectra.

  3. Hyperspectral surface materials map of quadrangles 3666 and 3766, Balkh (219), Mazar-e Sharif (220), Qarqin (213), and Hazara Toghai (214) quadrangles, Afghanistan, showing iron-bearing minerals and other materials

    Science.gov (United States)

    King, Trude V.V.; Hoefen, Todd M.; Kokaly, Raymond F.; Livo, Keith E.; Johnson, Michaela R.; Giles, Stuart A.

    2013-01-01

    This map shows the spatial distribution of selected iron-bearing minerals and other materials derived from analysis of airborne HyMap™ imaging spectrometer (hyperspectral) data of Afghanistan collected in late 2007. This map is one in a series of U.S. Geological Survey/Afghanistan Geological Survey quadrangle maps covering Afghanistan. Flown at an altitude of 50,000 feet (15,240 meters (m)), the HyMap™ imaging spectrometer measured reflected sunlight in 128 channels, covering wavelengths between 0.4 and 2.5 μm. The data were georeferenced, atmospherically corrected and converted to apparent surface reflectance, empirically adjusted using ground-based reflectance measurements, and combined into a mosaic with 23-m pixel spacing. Variations in water vapor and dust content of the atmosphere, in solar angle, and in surface elevation complicated correction; therefore, some classification differences may be present between adjacent flight lines. The reflectance spectrum of each pixel of HyMap™ imaging spectrometer data was compared to the reference materials in a spectral library of minerals, vegetation, water, and other materials. Minerals occurring abundantly at the surface and those having unique spectral features were easily detected and discriminated, while minerals having slightly different compositions but similar spectral features were less easily discriminated; thus, some map classes consist of several minerals having similar spectra, such as “Goethite and jarosite.” A designation of “Not classified” was assigned to the pixel when there was no match with reference spectra.

  4. Petrographic atlas characterisation of aggregates regarding potential reactivity to alkalis : RILEM TC 219-ACS recommended guidance AAR-1.2, for use with the RILEM AAR-1.1 petrographic examination method

    CERN Document Server

    Ribeiro, Maria; Broekmans, Maarten; Sims, Ian

    2016-01-01

    This RILEM AAR 1.2 Atlas is complementary to the petrographic method described in RILEM AAR 1.1. It is designed and intended to assist in the identification of alkali-reactive rock types in concrete aggregate by thin-section petrography. Additional issues include: • optical thin-section petrography conforming to RILEM AAR 1.1 is considered the prime assessment method for aggregate materials, being effective regarding cost and time. Unequivocal identification of minerals in very-fine grained rock types may however require use of supplementary methods. • the atlas adheres to internationally adopted schemes for rock classification and nomenclature, as recommended in AAR 1.1. Thus, rock types are classified as igneous, sedimentary or metamorphic based upon mineral content, microstructure and texture/fabric. • in addition, the atlas identifies known alkali-reactive silica types in each rock type presented. It also identifies consistent coincidence between certain lithologies and silica types; however, it ref...

  5. RILEM recommendations for the prevention of damage by alkali-aggregate reactions in new concrete structures state-of-the-art report of the RILEM technical committee 219-ACS

    CERN Document Server

    Sims, Ian

    2016-01-01

    This book contains the full set of RILEM Recommendations which have been produced to enable engineers, specifiers and testing houses to design and produce concrete which will not suffer damage arising from alkali reactions in the concrete. There are five recommended test methods for aggregates (designated AAR-1 to AAR-5), and an overall recommendation which describes how these should be used to enable a comprehensive aggregate assessment (AAR-0). Additionally, there are two Recommended International Specifications for concrete (AAR-7.1 & 7.2) and a Preliminary International Specification for dams and other hydro structures (AAR-7.3), which describe how the aggregate assessment can be combined with other measures in the design of the concrete to produce a concrete with a minimised risk of developing damage from alkali-aggregate reactions.

  6. Depaule Jean-Charles (avec la collaboration de Jean-Luc Arnaud, À travers le mur, Marseille, éditions Parenthèses, collection Eupalinos, 2014, 219 p.

    Directory of Open Access Journals (Sweden)

    Anna Madoeuf

    2014-09-01

    Full Text Available Saluons la réédition, aux éditions Parenthèses, dans la collection Eupalinos, d’À travers le mur, de Jean-Charles Depaule, ouvrage qui est tant une contribution rare et originale aux études urbaines, qu’un opus d’anthropologie sur l’espace habité, de même qu’une source de références multiples, notamment littéraires. « Rêver des lourdes portes, des passages en chicane et plus encore, peut-être des moucharabiehs perdus […] ». Cette sollicitation onirique et énigmatique, quatrième de couverture ...

  7. PENGARUH PENGGUNAAN GLIKOL PADA INSEKTISIDA AQUA-K-OTHRINE 20 EW® (b.a. Deltamethrin 21.9 g/l TERHADAP NYAMUK Aedes aegypti dan Culex quinquefasciatus DENGAN METODA PENGASAPAN(Thermal Fogging

    Directory of Open Access Journals (Sweden)

    Hasan Boesri

    2011-12-01

    Full Text Available ENGLISHK-OTHRINE 20 EW® insecticides were tested in 100 and 200 ml/ha with the application of fumigation using pure water as solvent and mixture of water and glycol. It was equally effective to kill Ae. aegypti mosquitoes indoor and outdoor with the mortality of 100%. Similarly, the insecticide effectively provides mortality of 90.0 – 94.8% to the Cx. quinquefasciatus mosquitoes, indoor and outdoor. The effect of fumigation of K-Othrine 20 EW® insecticide using either pure or mixed solvent of water (9.5 l water + 0.5 l glycol showed no difference to the mortality of mosquitoes, but glycol solution produce the fog, so the particle could be spread out to all directions.INDONESIAPengujian insektisida K-OTHRINE 20 EW® dosis 100 dan 200 ml/ha telah dilakukan dengan aplikasi pengasapan menggunakan pelarut air dan campuran air dengan glikol. Hasil menunjukkan keduanya sama-sama efektif membunuh nyamuk Aedes aegypti di dalam dan luar rumah (kematian 100%; terhadap Culex quinquefasciatus di dalam dan luar rumah efektif memberikan kematian 90.0 – 90.8%. Pengaruh aplikasi pengasapan insektisida K-Othrine 20 EW® baik menggunakan pelarut air maupun campuran (9.5 l air + 0.5 l glikol menunjukkan tidak berbeda terhadap kematian nyamuk uji, perbedaan pada larutan yang ditambah glikol dapat mengeluarkan kabut sehingga partikel yang dikeluarkan dapat tersebar ke semua arah.

  8. Hurdles for a Broader Use of 211At and for the Synthesis of 211At-Labelled Radiopharmaceuticals at High Activities for Clinical Use

    International Nuclear Information System (INIS)

    One of the key impediments to the use of 211At is the very well known deleterious effect of high radiation fields caused by its alpha particles on the synthesis of 211At-labelled radiopharmaceuticals. This is problematic because radiolysis-mediated effects can produce diminishing efficiency of electrophilic astatination reactions due to increasing deposition of radiation dose with increasing activities and with the passage of the time. Astatine-211 has chemical properties that permit complex labelling strategies and a longer half-life than 213Bi that makes it more suitable when the targeting molecule does not gain immediate access to the tumour cells. The first clinical evaluation was published in 2001 [2] in patients with brain tumour. Although this study circumvents many of the challenges to entering clinical studies with 211At and many obstacles had to be surmounted before clinical studies could be initiated, several problems were encountered in maintaining efficient labelling with escalating radiation dose of α-particle even with fresh 211At elution [3]. Astatine-211 also has an additional hurdle to overcome before to its clinical application in labelled radiopharmaceuticals related with its production and distribution. Among the potential group of promising α- emitter it is the only one produced by cyclotrons, but due to the scarcity of cyclotrons equipped with 25−30 MeV α-particle beams, it will of necessity be utilized in distant locations from the site of production. It presents a major chemical challenge because the diminishing efficiency of electrophilic astatination reactions with the passage of the time is well known, a problem likely related to the radiolysis produced by the high LET (linear energy transfer) meaning that large amounts of energy are deposited in a highly localized manner. This problem has been most comprehensively investigated to understand and evaluate the role of the radiolysis effects of astatine alpha particles in the synthesis

  9. $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with radioactive At beams

    CERN Multimedia

    We propose to study the $\\beta$-delayed fission, laser spectroscopy and radioactive decay of the newly available pure beams of neutron-deficient and neutron-rich astatine (Z=85) isotopes. The fission probability and the fission fragment distribution of the even-even isotopes $^{194,196}$Po following the $\\beta$-decay of the isotopes $^{194,196}$At will be studied with the Windmill setup. In-source laser spectroscopy will be performed on the entire astatine isotopic chain, using a combination of the Windmill setup, ISOLTRAP MR-ToF and ISOLDE Faraday. Radioactive decay data will be acquired at the Windmill setup throughout those studies and contribute to the global understanding of the phenomenon of shape coexistence in the neutron-deficient lead region.

  10. Production cross section of At radionuclides from $^{7}$Li+$^{\\textrm{nat}}$Pb and $^{9}$Be+$^{\\textrm{nat}}$Tl reactions

    CERN Document Server

    Maiti, Moumita

    2011-01-01

    Earlier we reported theoretical studies on the probable production of astatine radionuclides from $^{6,7}$Li and $^{9}$Be-induced reactions on natural lead and thalliun targets, respectively. For the first time, in this report, production of astatine radionuclides has been investigated experimentally with two heavy ion induced reactions: $^{9}$Be+$^{\\textrm{nat}}$Tl and $^{7}$Li+$^{\\textrm{nat}}$Pb. Formation cross sections of the evaporation residues, $^{207,208,209,210}$At, produced in (HI, xn) channel, have been measured by the stacked-foil technique followed by the off-line $\\gamma$-spectrometry at the low incident energies ($<$50 MeV). Measured excitation functions have been explained in terms of compound nuclear reaction mechanism using Weisskopf-Ewing and Hauser-Feshbach model. Absolute cross section values are lower than the respective theoretical predictions.

  11. Grids of Agricultural Pesticide Use in the Conterminous United States, 1997

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This spatial dataset consists of 219 1-kilometer (km) resolution grids depicting estimated agricultural use of 219 pesticides in 1997 for the conterminous United...

  12. Radiopharmaceutical Chemistry of Targeted Radiopharmaceutics. Synthesis of 211At-Labeled Radiopharmaceuticals at High Activities for Clinical Use

    International Nuclear Information System (INIS)

    Targeted α-particle radiotherapy is an appealing approach to cancer treatment because of the potential for delivering curative doses of radiation to tumor with minimal damage to normal tissue due to a range equivalent to only a few cell diameters. Compared with β-emitters they have significant advantages from a radiobiological perspective. The LET of 211At α-particles is more than 400 times higher than the β-particles emitted by 90Y, in addition the distance between ionizing events is almost the same as that between the two strands of DNA, yielding a high probability of creating non-repairable DNA damage. It gives the ability to kill cancer cells not compromised by hypoxia, dose rate effects or cell cycle position, enhancing their attractiveness for targeted radiotherapy. However, translation of the concept to the clinic has been slow, many obstacles had to be surmounted before clinical studies could be initiated, the first clinical evaluation of a 211At- labeled mAb was made in 2001. This study circumvents many of the challenges to entering clinical studies with 211At. But several problems were encountered in maintaining efficient labeling with escalating radiation dose of alpha-particle likely related to radiolysis. The impact of the radiolysis produced by the α-particle over the labeling chemistry is much higher in comparison with typical β-emitters due to a deposition of energy in the solvent in a highly localized manner two orders of magnitude per unit volume higher than 90Y or 131I. Due to these difficulties a comprehensive basic science study about the radiolytic effects of astatine alpha-particles over the synthesis of 211At-labeled radiopharmaceuticals was carried out. Its main goal was overcoming the problem of the synthesis of 211At-labeled radiopharmaceuticals at the high activities necessaries for therapy and also to extend the shelf life of astatine elutions. Briefly this study held several steps, the first one was to study the role of solvent

  13. Dietary exposure to benzoates (E210-E213), parabens (E214-E219), nitrites (E249-E250), nitrates (E251-E252), BHA (E320), BHT (E321) and aspartame (E951) in children less than 3 years old in France.

    Science.gov (United States)

    Mancini, F R; Paul, D; Gauvreau, J; Volatier, J L; Vin, K; Hulin, M

    2015-01-01

    This study aimed to estimate the exposure to seven additives (benzoates, parabens, nitrites, nitrates, BHA, BHT and aspartame) in children aged less than 3 years old in France. A conservative approach, combining individual consumption data with maximum permitted levels, was carried out for all the additives. More refined estimates using occurrence data obtained from products' labels (collected by the French Observatory of Food Quality) were conducted for those additives that exceeded the acceptable daily intake (ADI). Information on additives' occurrence was obtained from the food labels. When the ADI was still exceeded, the exposure estimate was further refined using measured concentration data, if available. When using the maximum permitted level (MPL), the ADI was exceeded for benzoates (1.94 mg kg(-1) bw day(-1)), nitrites (0.09 mg kg(-1) bw day(-1)) and BHA (0.39 mg kg(-1) bw day(-1)) in 25%, 54% and 20% of the entire study population respectively. The main food contributors identified with this approach were current foods as these additives are not authorised in specific infant food: vegetable soups and broths for both benzoates and BHA, delicatessen and meat for nitrites. The exposure estimate was significantly reduced when using occurrence data, but in the upper-bound scenario the ADI was still exceeded significantly by the age group 13-36 months for benzoates (2%) and BHA (1%), and by the age group 7-12 months (16%) and 13-36 months (58%) for nitrites. Measured concentration data were available exclusively for nitrites and the results obtained using these data showed that the nitrites' intake was below the ADI for all the population considered in this study. These results suggest that refinement of exposure, based on the assessment of food levels, is needed to estimate the exposure of children to BHA and benzoates for which the risk of exceeding the ADI cannot be excluded when using occurrence data. PMID:25686474

  14. Dietary exposure to benzoates (E210-E213), parabens (E214-E219), nitrites (E249-E250), nitrates (E251-E252), BHA (E320), BHT (E321) and aspartame (E951) in children less than 3 years old in France.

    Science.gov (United States)

    Mancini, F R; Paul, D; Gauvreau, J; Volatier, J L; Vin, K; Hulin, M

    2015-01-01

    This study aimed to estimate the exposure to seven additives (benzoates, parabens, nitrites, nitrates, BHA, BHT and aspartame) in children aged less than 3 years old in France. A conservative approach, combining individual consumption data with maximum permitted levels, was carried out for all the additives. More refined estimates using occurrence data obtained from products' labels (collected by the French Observatory of Food Quality) were conducted for those additives that exceeded the acceptable daily intake (ADI). Information on additives' occurrence was obtained from the food labels. When the ADI was still exceeded, the exposure estimate was further refined using measured concentration data, if available. When using the maximum permitted level (MPL), the ADI was exceeded for benzoates (1.94 mg kg(-1) bw day(-1)), nitrites (0.09 mg kg(-1) bw day(-1)) and BHA (0.39 mg kg(-1) bw day(-1)) in 25%, 54% and 20% of the entire study population respectively. The main food contributors identified with this approach were current foods as these additives are not authorised in specific infant food: vegetable soups and broths for both benzoates and BHA, delicatessen and meat for nitrites. The exposure estimate was significantly reduced when using occurrence data, but in the upper-bound scenario the ADI was still exceeded significantly by the age group 13-36 months for benzoates (2%) and BHA (1%), and by the age group 7-12 months (16%) and 13-36 months (58%) for nitrites. Measured concentration data were available exclusively for nitrites and the results obtained using these data showed that the nitrites' intake was below the ADI for all the population considered in this study. These results suggest that refinement of exposure, based on the assessment of food levels, is needed to estimate the exposure of children to BHA and benzoates for which the risk of exceeding the ADI cannot be excluded when using occurrence data.

  15. Decree of the State Office for Nuclear Safety No. 219/1997 of 22 August 1997 specifying details for emergency preparedness of nuclear facilities and workplaces handling ionizing radiation sources and specifying requirements for the contents of internal emergency plans and emergency rules

    International Nuclear Information System (INIS)

    The Decree addresses the following issues: definition of a radiological event and interventions to be accomplished if a radiological event takes place; emergency preparedness; establishing a radiological event; assessment of a radiological event; warnings, notifications and alarms during a radiological event; intervention - management, procedures, instructions; radiological situation monitoring programme; provisions to restrict human exposure; health care provisions; documentation; informing the State Office for Nuclear Safety; personnel instructions and training; emergency preparedness inspection; internal emergency plan; emergency rules; and related issues. (P.A.)

  16. Inclusive measurement of (p,πsup(-)xn) double charge exchange reactions on bismuth from threshold to 800 MeV

    International Nuclear Information System (INIS)

    The energy dependence of the total angle-integrated cross section for the production of astatine isotopes from (p,πsup(-)xn) double charge exchange reactions on bismuth (sup(209)Bi) was measured from 120 to 800 MeV using activation and radiochemical techniques. Chemical yields were estimated by direct radioassaying of sup(211)At activity in thin (approximately 1 mg/cmsup(2)), irradiated bismuth targets. Calculations of the contributions of secondary (2-step) reactions to these measured astatine yields were performed, based partially upon the observed sup(211)At activity although even at the highest energies, the contribution to products lighter than sup(207)At was negligible. These data for products with as many as 7 neutrons removed from the doubly coherent product (sup(210)At) display nearby gaussian shapes for the mass distributions of the astatine residues with the maximum occurring for about sup(204)At. The most probable momentum transfer deduced from these distributions for the initial πsup(-) production step was 335 MeV/c. The observed excitation functions display a behaviour similar to that observed for the yield of sup(210)Po from a (p,πsup(O)) reaction on sup(209)Bi, but radically different from that observed for inclusive πsup(-) reactions on a heavy nucleus. These data are discussed in terms of recent theoretical approaches to negative pion production from bismuth. In addition, a simple, schematic model is developed to treat the rapidly decreasing percentage of the total inclusive πsup(-) emission which is observed for this double charge exchange reaction. This model reflects the capacity of a nucleus to a source of internal energetic protons

  17. Human radiation studies: Remembering the early years: Oral history of Dr. Patricia Wallace Durbin, Ph.D., conducted November 11, 1994

    International Nuclear Information System (INIS)

    This report is a transcript of an interview of Dr. Patricia Wallace Durbin by representatives of the US DOE Office of Human Radiation Research. Dr. Durbin was selected for this interview because of her knowledge of the human plutonium injections and her recollections of key figures, especially Joseph Hamilton. After a brief biographical sketch Dr. Durbin discusses her loss of research funding from DOE, her recollections concerning research into strontium metabolism as part of Project Sunshine, her recollections relating to the rationale for studies of human metabolism of radionuclides, her remembrances of Dr. Hamilton's Astatine and Plutonium research, and her experiences in gathering archival records concerning these researches

  18. EFFECT OF MECHANICAL PROPERTIES OF MARTENSITE AND LOADING RATE ON DUAL PHASE STEELS

    OpenAIRE

    BAYRAM, Ali

    1998-01-01

    In this study, steel sheet materials were used in order to obtain dual-phase steel. Specimens for this purpose have been annealed in ferrite + astatine regions at the temperatures of 740, 760, 800 and 820 °C. The specimens were annealed at the different temperatures with corresponding times 20, 40 and 60 minutes and quenched into water. As a result of this dual-phase steels at different ferrite + martensite ratio were produced. Sheet specimens were tested at the range of loading rates of 1...

  19. EST Table: FS871503 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS871503 E_FL_fner_45K10_R_0 10/09/28 90 %/219 aa ref|NP_001036841.1| Annexin IX is...oform A [Bombyx mori] dbj|BAA92809.1| annexin IX-A [Bombyx mori] 10/09/11 73 %/219 aa FBpp0280989|DpseGA1909...1|gene:ANXB9 10/09/10 61 %/219 aa gnl|Amel|GB16448-PA 10/09/10 73 %/219 aa gi|91092420|ref|XP_967931.1| PREDICTED: similar to Annexin IX CG5730-PC [Tribolium castaneum] FS780436 fner ...

  20. Dicty_cDB: Contig-U13619-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available aaggc 490 Query: 491 tcaagatctttatgaagaggangatactgatcgtgcattattattaagtgaaaaagcagc 550 ||||||||||||||||||||||...|||||||||||||||||||||||||||||||||||||| Sbjct: 491 tcaagatctttatgaagaggangatactgat...|||||||||||||| Sbjct: 219 tgttcagtatatgaaaaagatcgntgaaaaaggtgcatgggcaatcatattancaaaggc 160 Query: 491 tcaagatctttatgaagagganga...|||||||||||||||||||||||||||||||||||||| Sbjct: 159 tcaagatctttatgaagaggangatactgatcgtgcattattattaagtgaaaaagca

  1. Dicty_cDB: Contig-U04658-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available tagtgaacaagtaaacatattttcagaagangaagaaaccgaagtaaaa 218 ||||||||||||||||||||||||||||||||||||||||||||||||||||||...|||||| Sbjct: 159 aatatttcaaatagtgaacaagtaaacatattttcagaagangaagaaaccgaagtaaaa 21...| Sbjct: 159 aatatttcaaatagtgaacaagtaaacatattttcagaagangaagaaaccgaagtaaaa 218 Query: 219 ggtgaaaaagatatagaat...acatggttctccattgtcagatattaaaacaccaaaacctttatatttt 158 Query: 159 aatatttcaaatagtg...aacaagtaaacatattttcagaagangaagaaaccgaagtaaaa 218 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||

  2. Alpha-decay studies of the new isotopes sup 1 sup 9 sup 1 At and sup 1 sup 9 sup 3 At

    CERN Document Server

    Kettunen, H; Grahn, T; Greenlees, P T; Jones, P; Julin, R; Juutinen, S; Keenan, A; Kuusiniemi, P; Leino, M; Leppaenen, A P; Nieminen, P; Pakarinen, J; Rahkila, P; Uusitalo, J

    2003-01-01

    Detailed alpha-decay studies have been performed for the neutron-deficient isotopes sup 1 sup 9 sup 1 At and sup 1 sup 9 sup 3 At. The nuclei were produced in fusion-evaporation reactions of sup 5 sup 4 Fe and sup 5 sup 6 Fe ions with a sup 1 sup 4 sup 1 Pr target. The fusion products were separated in-flight using a gas-filled recoil separator and implanted into a position-sensitive silicon detector. The isotopes were identified using position, time and energy correlations between the implants and subsequent alpha-decays. Three alpha-decaying states were identified for sup 1 sup 9 sup 3 At and two for sup 1 sup 9 sup 1 At. The spin and parity of the initial states in the astatine isotopes were deduced based on unhindered alpha-decays to states in the bismuth daughter nuclei. In both astatine isotopes the 1/2 sup + intruder state was determined to be the ground state and a 7/2 sup - state to be the first-excited state. In sup 1 sup 9 sup 3 At the alpha-decay of the 13/2 sup + state was observed in coincidence...

  3. Rationalization of the solvation effects on the AtO+ ground-state change.

    Science.gov (United States)

    Ayed, Tahra; Réal, Florent; Montavon, Gilles; Galland, Nicolas

    2013-09-12

    (211)At radionuclide is of considerable interest as a radiotherapeutic agent for targeted alpha therapy in nuclear medicine, but major obstacles remain because the basic chemistry of astatine (At) is not well understood. The AtO(+) cationic form might be currently used for (211)At-labeling protocols in aqueous solution and has proved to readily react with inorganic/organic ligands. But AtO(+) reactivity must be hindered at first glance by spin restriction quantum rules: the ground state of the free cation has a dominant triplet character. Investigating AtO(+) clustered with an increasing number of water molecules and using various flavors of relativistic quantum methods, we found that AtO(+) adopts in solution a Kramers restricted closed-shell configuration resembling a scalar-relativistic singlet. The ground-state change was traced back to strong interactions, namely, attractive electrostatic interactions and charge transfer, with water molecules of the first solvation shell that lift up the degeneracy of the frontier π* molecular orbitals (MOs). This peculiarity brings an alternative explanation to the highly variable reproducibility reported for some astatine reactions: depending on the production protocols (with distillation in gas-phase or "wet chemistry" extraction), (211)At may or may not readily react. PMID:23944251

  4. Dicty_cDB: Contig-U06096-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available |||||||||||| Sbjct: 64 gaaatngatgntncaacnccaacaatggctgcaaanattttttnnccnttttcaattggt 123 Query: 124 ggnaatgttggngatgntacaacnccna...ctt 154 ||||||||||||||||||||||||||||||| Sbjct: 124 ggnaatgttggngatgntacaacnccnactt 154 Sc...us Query: 219 atcncaacnatnncaacaacnaactgaatcagaattacnaccnattcaaa 268 |||||||||||||||||||||||||||||||||||||||...||||||||||| Sbjct: 219 atcncaacnatnncaacaacnaactgaatcagaattacnaccnattcaaa 268 >Contig-U11917-1 (Contig-U1191...atgntncaacnccaacaatggctgcaaanattttttnnccnttttcaattggt 147 Query: 124 ggnaatgttggngatgntacaacnccnacttnaaaanaa

  5. 75 FR 53280 - National Board for Education Sciences

    Science.gov (United States)

    2010-08-31

    ... CONTACT: Norma Garza, Executive Director, National Board for Education Sciences, 555 New Jersey Ave., NW., Room 602K, Washington, DC 20208; phone: (202) 219-2195; fax: (202) 219-1466; e-mail: Norma.Garza@ed.gov... alternative format) should notify Norma Garza no later than September 20. We will attempt to meet requests...

  6. 75 FR 13265 - National Board for Education Sciences

    Science.gov (United States)

    2010-03-19

    .... ADDRESSES: 80 F Street, NW., Room 100, Washington, DC 20208. FOR FURTHER INFORMATION CONTACT: Norma Garza..., DC 20208; phone: (202) 219-2195; fax: (202) 219- 1466; e-mail: Norma.Garza@ed.gov . Individuals who...:30 p.m. A final agenda will be available from Norma Garza (see contact information above) on March...

  7. 77 FR 44144 - National Forest System Land Management Planning; Correction

    Science.gov (United States)

    2012-07-27

    ... Forest Service 36 CFR Part 219 RIN 0596-AD02 National Forest System Land Management Planning; Correction...) published a National Forest System land management planning rule in the Federal Register, on April 9, 2012..., Subpart A--National Forest System Land Management Planning (36 CFR part 219, subpart A). One...

  8. 77 FR 76936 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

    Science.gov (United States)

    2012-12-31

    ..., Contractor Code of Business Ethics and Conduct, is the DoD Office of Inspector General at the following...'' and adding ``datafax (571) 372-6094'' in its place. PART 203--IMPROPER BUSINESS PRACTICES AND PERSONAL.../ CPF'' and adding ``DPAP/CPIC'' in its place. PART 219--SMALL BUSINESS PROGRAMS 219.202-1 0 8....

  9. 75 FR 40019 - In the Matter of the Review of the Designation of the Communist Party of the Philippines/New...

    Science.gov (United States)

    2010-07-13

    ... Matter of the Review of the Designation of the Communist Party of the Philippines/New People's Army (aka... matter pursuant to Section 219(a)(4)(C) of the Immigration and Nationality Act, as amended (8 U.S.C. 1189... organization as a foreign terrorist organization, pursuant to Section 219 of the INA (8 U.S.C. 1189), shall...

  10. EST Table: BY937615 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available BY937615 E_FL_e100_02B06_F_0 10/09/28 88 %/219 aa gb|EEZ97711.1| Ras opposite [Trib... aa gnl|Amel|GB12540-PA 10/09/10 88 %/219 aa gi|270001264|gb|EEZ97711.1| Ras opposite [Tribolium castaneum] FS768412 e100 ...

  11. 48 CFR 4.1202 - Solicitation provision and contract clause.

    Science.gov (United States)

    2010-10-01

    ... Low Bids. (k) 52.219-19, Small Business Concern Representation for the Small Business Competitiveness... the Small Business Competitiveness Demonstration Program. (m) 52.219-22, Small Disadvantaged Business... Identification. (d) 52.204-5, Women-Owned Business (Other Than Small Business). (e) 52.209-5,...

  12. 48 CFR 52.204-8 - Annual Representations and Certifications.

    Science.gov (United States)

    2010-10-01

    ... Officer: __(i) 52.219-19, Small Business Concern Representation for the Small Business Competitiveness... Under the Small Business Competitiveness Demonstration Program. ___(iii) 52.219-22, Small Disadvantaged... Classification System (NAICS) code for this acquisition is _______ . (2) The small business size standard...

  13. Modélisation pluie-débit en région tropicale humide : application des réseaux de neurones sur quatre stations hydrométriques du Bandama Blanc (Bada, Marabadiassa, Tortiya et Bou situées au Nord de la Côte d'Ivoire. Thèse de l'Université de Cocody (Côte d'Ivoire, 2007, 219 p.

    Directory of Open Access Journals (Sweden)

    Yao Blaise Koffi

    2009-12-01

    Full Text Available La relation pluie-débit fait l'objet de nombreuses études, à cause de son importance dans la mise en œuvre de nombreux projets de développement. La communauté scientifique, dans le souci de faire face aux problèmes d'eau, tels que les inondations et les sècheresses, utilise différents modèles. Mais ces modèles sont généralement confrontés à la non-linéarité de la relation pluie-débit. Dans le cas du Bandama Blanc, objet de cette étude, cette non-linéarité est accentuée par la présence de plusieurs barrages à vocation agro-pastorale situés dans la partie nord de la zone d'étude et qui utilisent les eaux de ce fleuve. Ce mémoire de thèse traite donc de la modélisation des débits mensuels du Bandama Blanc, aux stations de Bada, Marabadiassa, Tortiya et Bou, à l'aide des réseaux de neurones, déjà éprouvés dans ce contexte de relation non-linéaire. Elle projette de fournir des outils plus robustes aux hydrologues africains pour la simulation et la prévision des débits des rivières jaugées. Pour atteindre cet objectif, deux Perceptrons Multicouches entraînés avec l'algorithme de la rétropropagation de l'erreur ont été construits. Le premier modèle a été utilisé seulement en simulation et le second en simulation et en prévision. Le modèle conceptuel GR2M, a été utilisé pour valider les résultats obtenus avec les réseaux de neurones. Pour cette étude, une importante base de données climatiques (pluie et température et hydrométriques (débits mensuels a été utilisée. Les résultats obtenus sont forts satisfaisants et nettement supérieurs à ceux obtenus avec le modèle conceptuel global GR2M. En effet, les réseaux de neurones parviennent à expliquer plus de 70 % de la variation des débits, avec des coefficients de corrélation de Pearson qui excèdent 0,80. Cependant ces modèles arrivent difficilement à simuler et à faire la prévision des débits extrêmes (étiages et crues, à cause probablement du nombre réduit de données à notre disposition et de la séparation des bases de calage et de validation.The rainfall-runoff relationship is the subject of many studies because of its importance in the implementation of many development projects. The scientific community, in order to cope with water problems such as floods and droughts, used different models. But these models are usually faced with the non-linearity of the rainfall-runoff relationship. In the case of the Bandama Blanc purpose of this study, this non-linearity is enhanced by the presence of several agro-pastoral dams located in the northern part of the study area and using the waters of this river. This thesis therefore deals with the modeling of flows of Bandama Blanc hydrometric stations (Bada Marabadiassa, Tortiya and Bou using neural networks already experienced in the context of non-linear relationship. It plans to provide more robust tools to African hydrologist in the simulation and forecasting of river flows. To achieve this goal, two Multilayer Perceptrons trained with the backpropagation algorithm of error have been built. The first model was used only in simulation and the second in simulation and prediction. The conceptual model GR2M was used to validate the results obtained with neural networks. An extensive database climate (rainfall and temperature and river monthly flow was used in this study. The results obtained are very satisfactory and well above those obtained with the overall conceptual model GR2M. Indeed, neural networks are able to explain more than 70% of the variation in rates, with Pearson correlation coefficients exceeding 0.80. However, these models have difficulty to simulate and predict extremes flow probably because of the reduced number of data at our disposal and separation of bases calibration and validation.

  14. Source identification in two criminal cases using phylogenetic analysis of HIV-1 DNA sequences.

    Science.gov (United States)

    Scaduto, Diane I; Brown, Jeremy M; Haaland, Wade C; Zwickl, Derrick J; Hillis, David M; Metzker, Michael L

    2010-12-14

    Phylogenetic analysis has been widely used to test the a priori hypothesis of epidemiological clustering in suspected transmission chains of HIV-1. Among studies showing strong support for relatedness between HIV samples obtained from infected individuals, evidence for the direction of transmission between epidemiologically related pairs has been lacking. During transmission of HIV, a genetic bottleneck occurs, resulting in the paraphyly of source viruses with respect to those of the recipient. This paraphyly establishes the direction of transmission, from which the source can then be inferred. Here, we present methods and results from two criminal cases, State of Washington v Anthony Eugene Whitfield, case number 04-1-0617-5 (Superior Court of the State of Washington, Thurston County, 2004) and State of Texas v Philippe Padieu, case numbers 219-82276-07, 219-82277-07, 219-82278-07, 219-82279-07, 219-82280-07, and 219-82705-07 (219th Judicial District Court, Collin County, TX, 2009), which provided evidence that direction can be established from blinded case samples. The observed paraphyly from each case study led to the identification of an inferred source (i.e., index case), whose identity was revealed at trial to be that of the defendant. PMID:21078965

  15. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    CERN Document Server

    Marsh, B A; Imai, N; Seliverstov, M D; Rothe, S; Sels, S; Capponi, L; Rossel, R E; Franchoo, S; Wendt, K; Focker, G J; Kalaninova, Z; Sjoedin, A M; Popescu, L; Nicol, T; Huyse, M; Radulov, D; Atanasov, D; Kesteloot, N; Borgmann, Ch; Cocolios, T E; Lecesne, N; Ghys, L; Pauwels, D; Rapisarda, E; Kreim, S; Liberati, V; Wolf, R N; Andel, B; Schweikhard, L; Lane, J; Derkx, X; Kudryavtsev, Yu; Zemlyanoy, S G; Fedosseev, V N; Lynch, K M; Rosenbusch, M; Van Duppen, P; Lunney, D; Manea, V; Barzakh, A E; Andreyev, A N; Truesdale, V; Flanagan, K T; Molkanov, P L; Koester, U; Van Beveren, C; Wienholtz, F; Goodacre, T Day; Antalic, S; Bastin, B; De Witte, H; Fink, D A; Fedorov, D V

    2013-01-01

    At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar fr...

  16. Development of 211At Chemistry for Labelling Biomolecules

    International Nuclear Information System (INIS)

    Our studies have demonstrated that high recovery of 211At can be obtained using a “wet chemistry” approach to isolation from the bismuth target. We have also demonstrated that direct labelling of antibody-B10 conjugates with 211At can be performed in high yields, and that the astatinated antibodies are stable to in vivo deastatination. While these results will allow us to enter clinical studies with 211At-labelled antibodies, the chemistry associated with 211At is not fully understood. Therefore, it is important that many more basic studies to be conducted with 211At, so the optimal labelling reagent for each type of disease-targeting agent becomes apparent

  17. Alpha particle induced DNA damage and repair in normal cultured thyrocytes of different proliferation status

    DEFF Research Database (Denmark)

    Lyckesvärd, Madeleine Nordén; Delle, Ulla; Kahu, Helena;

    2014-01-01

    Childhood exposure to ionizing radiation increases the risk of developing thyroid cancer later in life and this is suggested to be due to higher proliferation of the young thyroid. The interest of using high-LET alpha particles from Astatine-211 ((211)At), concentrated in the thyroid by the same...... levels of γH2AX decreased during the first 24h in both cycling and stationary cultures and complete repair was seen in all cultures but cycling cells exposed to (211)At. Compared to stationary cells alpha particles were more harmful for cycling cultures, an effect also seen at the pChk2 levels...... cultures at a modest level of damage, clearly demonstrating that cell cycle status influences the relative effectiveness of alpha particles....

  18. EFFECT OF MECHANICAL PROPERTIES OF MARTENSITE AND LOADING RATE ON DUAL PHASE STEELS

    Directory of Open Access Journals (Sweden)

    Ali BAYRAM

    1998-03-01

    Full Text Available In this study, steel sheet materials were used in order to obtain dual-phase steel. Specimens for this purpose have been annealed in ferrite + astatine regions at the temperatures of 740, 760, 800 and 820 °C. The specimens were annealed at the different temperatures with corresponding times 20, 40 and 60 minutes and quenched into water. As a result of this dual-phase steels at different ferrite + martensite ratio were produced. Sheet specimens were tested at the range of loading rates of 10, 50 and 259 mm/min. Strength properties of dual-phase steels were investigated depending on annealing temperature, ratio of martensite and loading rate.

  19. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    Energy Technology Data Exchange (ETDEWEB)

    Marsh, B.A., E-mail: bruce.marsh@cern.ch [CERN, CH-1211 Geneva (Switzerland); Andel, B. [Comenius University, Bratislava (Slovakia); Andreyev, A.N. [University of York, Department of Physics, York YO10 5DD (United Kingdom); Antalic, S. [Comenius University, Bratislava (Slovakia); Atanasov, D. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Barzakh, A.E. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Bastin, B. [Grand Accérateur National d’Ions Lourds (GANIL), Bd Henri Becquerel, F-14076 Caen (France); Borgmann, Ch. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Capponi, L. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Cocolios, T.E.; Day Goodacre, T. [CERN, CH-1211 Geneva (Switzerland); University of Manchester, Manchester (United Kingdom); Dehairs, M. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Derkx, X. [University of the West of Scotland, School of Engineering, Paisley PA1 2BE (United Kingdom); De Witte, H. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Fedorov, D.V. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Fedosseev, V.N.; Focker, G.J. [CERN, CH-1211 Geneva (Switzerland); Fink, D.A. [Ruprecht-Karls Universität, Seminarstr. 2, 69117 Heidelberg (Germany); CERN, CH-1211 Geneva (Switzerland); Flanagan, K.T. [University of Manchester, Manchester (United Kingdom); Franchoo, S. [CSNSM-IN2P3-CNRS, Université Paris-Sud, 91406 Orsay (France); and others

    2013-12-15

    Highlights: • Upgrade of the lasers, detectors and data acquisition for in-source resonance ionization spectroscopy at ISOLDE. • First use of the ISOLTRAP MR-ToF MS in combination with laser spectroscopy at ISOLDE. • Resonance ionization of astatine for the study of its nuclear structure. -- Abstract: At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar free ionization using the Laser Ion Source Trap, LIST (Po); isobar selective particle identification using the multi-reflection time-of-flight mass separator (MR-ToF MS) of ISOLTRAP (Au, At). These are summarized as part of an overview of the current status of the in-source resonance ionization spectroscopy setup at ISOLDE.

  20. Dicty_cDB: Contig-U14270-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available |||||||||| Sbjct: 191 gttcaacacaatgcngntcngcaacatgctganccagntgccaagccagccgaattaacc 250 Query: 251 natgcccnagaattncaacaagaacaccna...||||||| Sbjct: 251 natgcccnagaattncaacaagaacaccnaagncaagnagctctcgcaaaacnncnngct 3...10 Query: 311 cgtattagncaacaaaatcntgtcaaacaagcngcccnanagaaacgaacctcgcnacgt 370 |||||||||||||||||||||||||||||...||||||||||||||||||||||||||||||| Sbjct: 311 cgtattagncaacaaaatcntgtcaaacaagcngcccnanagaaacgaacctcgcnacgt 370 ...ct: 219 cngctgctcngggggctgccaanccagttcaacacaatgcngntcngcaacatgctganc 160 Query: 225 cagntgccaagccagccgaattaaccnatgcccna

  1. Ühiskonna kihistumine kui raskendav tegur riigi suhtlemisel rahvaga / Agu Uudelepp

    Index Scriptorium Estoniae

    Uudelepp, Agu, 1974-

    2002-01-01

    Bibliogr. lk. 219. Poliitikud peaksid rahvaga rääkides arvestama 4 etappi: veenmise eeltöö, usaldusväärsuse saavutamine, sõnumi koostamine ja edastamisviisi valimine ning emotsioonide äratamine

  2. Data of evolutionary structure change: 1WQLA-2GBXE [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1WQLA-2GBXE 1WQL 2GBX A E NWSDEEIKALVDEEKGLLDPRIFSDQDLYEIELERVFAR...HHHHHHHHHHHHHHH HHHHGGG HHHHHHHH 0 1WQL... A 1WQLA KTSYV-YSEEALEU CA 219 ASP CA 198 1WQL... A 1WQLA EKEAFCDCGFD <

  3. An open-label study to assess the effect of a single dose of Nebivolol and Ivabradine on heart rate and pulse wave velocity in hypertensive patients receiving amlodipine

    Directory of Open Access Journals (Sweden)

    Rama Mohan Pathapati

    2015-04-01

    Conclusions: Nebivolol is an effective HR lowering agent compared to Ivabradine. However, significant decrease in arterial stiffness was observed with Ivabradine. [Int J Basic Clin Pharmacol 2015; 4(2.000: 219-223

  4. An exploratory study of the interaction of cognitive complexity, dogmatism, and repression-sensitization among college students

    Science.gov (United States)

    Starbird, Dannel H.; Biller, Henry B.

    1976-01-01

    A total of 219 male and female college students returned questionnaire measures relating to cognitive complexity, dogmatism, and repression-sensitization. Analyses revealed very complex interactions among the variables. (Author/SB)

  5. 40 CFR 80.365 - What records must be kept?

    Science.gov (United States)

    2010-07-01

    ...; and (iv) If appropriate, the designation of the batch as GPA gasoline under § 80.219, California... allotments; and for credit generation or use starting in 2004, separately kept for GPA gasoline and...

  6. Gene : CBRC-ACAR-01-0376 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available 219.3| AGAP008244-PA [Anopheles gambiae str. PEST] gb|EAL39610.3| AGAP008244-PA [Anopheles gambiae str. PEST...GTIAGTSESPRAQETTSLKSTKTPTSESTTLSETTSLERTIEGISESTVVQETTSLETTTAATTLSSRAQEITSPESTKIP...TSESTTLSETTSSESAMSATTESPRAQETTSPDITTAATSESTTLSEKTSPESTIAGTSQSTVVQETTSPEGTIAATSESPKAQETTSPESTKTAASESTPLPKTVSPEST...ITGRSESTIVQETTSPDGTTAATSESTVVQETTSPESTTAATSESPRAQETTSPESTTAATPESSKLSETTSPESTIAGTSQSTVVQETTSPDSTTAATSESQRAHKTTSPEST...KTAKSESTTVSVTISPECTIAGTSESTVVQKNTFPESTTAATSESTPLSETTSPESTIARTSESIVVQETTSPEST

  7. Doctoral Theses in Library and Information Science Completed in Indian Universities, 2001-2007

    Science.gov (United States)

    Mestri, D. D.

    2008-01-01

    Provides a complete listing and analysis of 219 doctoral theses submitted to the departments of library and information science (DLIS) in 45 Indian universities between January 2001 and December 2007. (Contains 10 tables.)

  8. 78 FR 77710 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

    Science.gov (United States)

    2013-12-24

    ...., Bridgeport, 13001049 Brown--Henry House, 818 Fields Ave., Frankfort, 13001050 Point Breeze, 219 Riverview St... Madison County Churchill Weavers, 100 Churchill Dr., Berea, 13001054 Trimble County Norfolk Farm...

  9. 22 CFR 1203.735-216 - Miscellaneous statutory provisions.

    Science.gov (United States)

    2010-04-01

    ... Government (18 U.S.C. 285). (15) The prohibition against political activities in subchapter III of chapter 73... (18 U.S.C. 219). (17) The prohibition against discrimination because of politics, race, religion,...

  10. Main: GBOXSORBCS1 [PLACE

    Lifescience Database Archive (English)

    Full Text Available .) RBCS-1 gene promoter; Located between -219 and -212; G-box trimer confers relatively high level expression in roots; RBCS-1; G-box; root; spinach (Spinacia oleracea) TCCACGTGGT ...

  11. Drug: D09952 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available ACE VTHQGLSSPV TKSFNRGEC (Disulfide bridge: 23-93; 139-199; H130-L219, Dimer) Peptide Treatment of Alzheim...er's disease monoclonal antibody beta-amyloid CAS: 1178862-65-1 PubChem: 124490631 ...

  12. Medline Plus

    Full Text Available ... Flash Player for free at www.adobe.com/products/flashplayer . The videos open in a second window. ... Angioplasty Stent Placement (Shawnee Mission Medical Center, Merriam, KS, 2/19/ ...

  13. U.S. Health Report Card Finds Racial, Ethnic Disparities Persist

    Science.gov (United States)

    ... percent in 2014). Childhood obesity rates varied widely, too. Hispanics ages 2 to 19 had the highest rate of obesity (21.9 percent) between 2011 and 2014 while Asians had the lowest rate (8.6 percent). Hispanic ...

  14. Explanatory Style of Secondary Vocational Educators.

    Science.gov (United States)

    Hall, Helen C.; Smith, Bettye P.

    1999-01-01

    A study of the explanatory style of secondary vocational education in Georgia (n=219) indicated that most had an optimistic explanatory style. Business teachers were most likely and agriculture teachers least likely to use this style. (JOW)

  15. Domain Modeling: NP_872414.2 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_872414.2 chr12 Crystal structure of a human Notch1 ankyrin domain mutant p2qc9b_ chr12/NP_872414.2.../NP_872414.2_apo_18-219.pdb p2he0a_ chr12/NP_872414.2/NP_872414.2_holo_18-219.pdb psi-blast 305L,306D,307H,308L,309V,340K EDO 1 ...

  16. Mechanisms of protein sequence divergence and incompatibility.

    Directory of Open Access Journals (Sweden)

    Alon Wellner

    Full Text Available Alignments of orthologous protein sequences convey a complex picture. Some positions are utterly conserved whilst others have diverged to variable degrees. Amongst the latter, many are non-exchangeable between extant sequences. How do functionally critical and highly conserved residues diverge? Why and how did these exchanges become incompatible within contemporary sequences? Our model is phosphoglycerate kinase (PGK, where lysine 219 is an essential active-site residue completely conserved throughout Eukaryota and Bacteria, and serine is found only in archaeal PGKs. Contemporary sequences tested exhibited complete loss of function upon exchanges at 219. However, a directed evolution experiment revealed that two mutations were sufficient for human PGK to become functional with serine at position 219. These two mutations made position 219 permissive not only for serine and lysine, but also to a range of other amino acids seen in archaeal PGKs. The identified trajectories that enabled exchanges at 219 show marked sign epistasis - a relatively small loss of function with respect to one amino acid (lysine versus a large gain with another (serine, and other amino acids. Our findings support the view that, as theoretically described, the trajectories underlining the divergence of critical positions are dominated by sign epistatic interactions. Such trajectories are an outcome of rare mutational combinations. Nonetheless, as suggested by the laboratory enabled K219S exchange, given enough time and variability in selection levels, even utterly conserved and functionally essential residues may change.

  17. Isolation and characterization of a novel endoglucanase from a Bursaphelenchus xylophilus metagenomic library.

    Directory of Open Access Journals (Sweden)

    Lin Zhang

    Full Text Available A novel gene (designated as cen219 encoding endoglucanase was isolated from a Bursaphelenchus xylophilus metagenomic library by functional screening. Sequence analysis revealed that cen219 encoded a protein of 367 amino acids. SDS-PAGE analysis of purified endoglucanase suggested that Cen219 was a monomeric enzyme with a molecular mass of 40 kDa. The optimum temperature and pH for endoglucanase activity of Cen219 was separately 50 °C and 6.0. It was stable from 30 to 50 °C, and from pH 4.0 to 7.0. The activity was significantly enhanced by Mn(2+ and dramatically reduced by detergent SDS and metals Fe(3+, Cu(2+ or Hg(2+. The enzyme hydrolyzed a wide range of β-1, 3-, and β-1, 4-linked polysaccharides, with varying activities. Activities towards microcrystalline cellulose and filter paper were relatively high, while the highest activity was towards oat gum. The Km and Vmax of Cen219 towards CMC was 17.37 mg/ml and 333.33 U/mg, respectively. The findings have an insight into understanding the molecular basis of host-parasite interactions in B. xylophilus species. The properties also make Cen219 an interesting enzyme for biotechnological application.

  18. AcEST: BP917738 [AcEST

    Lifescience Database Archive (English)

    Full Text Available YMU001_000104_G10 219 Adiantum capillus-veneris mRNA. clone: YMU001_000104_G10. BP9177...38 CL2559Contig1 Show BP917738 Clone id YMU001_000104_G10 Library YMU01 Length 219 Definition Adiantum ca...pillus-veneris mRNA. clone: YMU001_000104_G10. Accession BP917738 Tissue type prothallium Developmental stag...s Res. 25:3389-3402. Query= BP917738|Adiantum capillus-veneris mRNA, clone: YMU001_000104_G10. (219 letters)... Res. 25:3389-3402. Query= BP917738|Adiantum capillus-veneris mRNA, clone: YMU001

  19. Posttranslational Modifications of Human Thrombin Activatable Fibrinolysis Inhibitor (TAFI): Evidence for a large shift in isoelectric point and reduced solubility upon activation

    DEFF Research Database (Denmark)

    Valnickova, Zuzana; Christensen, Trine; Skottrup, Peter;

    2006-01-01

    dramatically from pH 5 toward pH 8 upon activation and (ii) TAFIa is significantly less soluble than TAFI. The structural bases for these observations were investigated by characterizing all post-translational modifications, including attached glycans and disulfide connectivity. The analyses revealed that all...... five potential N-glycosylation sites were utilized including Asn22, Asn51, Asn63, Asn86 (located in the activation peptide), and Asn219 (located in the catalytic domain). Asn219 was also found in an unglycosylated variant. Four of the glycans, Asn51, Asn63, Asn86, and Asn219 displayed...... microheterogeneity, while the glycan attached to Asn22 appeared to be homogeneous. In addition, bisecting GlcNAc attached to the trimannose core was detected, suggesting an origin other than the liver. Monosaccharide composition and LC-MS/MS analyses did not produce evidence for O glycosylation. TAFI contains eight...

  20. Elsevier收录材料科学类期刊可开放获取情况的调查与分析

    Institute of Scientific and Technical Information of China (English)

    何燕; 瞿其春; 张雪娟

    2014-01-01

    对Elsevier旗下的SDOL数据库中的219种材料科学类期刊进行有关OA方面的研究,调查发现,在OSD和DOAJ这两大OA平台上,这219种期刊的可OA情况不容乐观。在SDOL数据库中,可OA的材料科学类期刊种数为数不少,但其中可OA期刊全文的并不多。将这219种期刊区分为完全OA期刊、部分OA期刊和完全非OA期刊,并对其质量进行了对比研究,认为Elsevier中材料科学类期刊的OA情况不是十分乐观,需业界的进一步推动。

  1. UREDNIČKI OPOZIV RADA: Fleksibilni Fourierov stacionarni test BDP-a po stanovniku za Srednjoistočne europske zemlje

    OpenAIRE

    Chang, Hsu-Ling; Su, Chi-Wei; Zhu, Meng-Nan

    2011-01-01

    Statement of Retraction (Zb. rad. Ekon. fak. Rij. • 2012 • vol. 30 • sv. 2 • 219-219, http://www.efri.uniri.hr/dokumenti/zbornik-2012-2-retraction.pdf): Želimo obavijestiti poštovane čitatelje da je Urednički odbor časopisa Zbornik radova Ekonomskog fakulteta u Rijeci, časopis za ekonomsku teoriju i praksu/ Proceedings of Rijeka Faculty of Economics, Journal of Economics and Business povukao sljedeći članak iz publikacije: “Flexible Fourier Stationary Test in GDP per capita for Cent...

  2. A Study of Selected Isozymes in Capsicum baccatum, Capsicum eximium, Capsicum cardenasii and Two Interspecific F1 Hybrids in Capsicum Species

    OpenAIRE

    Ahmet Naci ONUS

    2000-01-01

    Selected isozymes were investigated in plants of Capsicum baccatum L. ( Solanaceae) accessions SA219 (P.G.Smith), Hawkes 6489 (P.G.Smith), Capsicum cardenasii Heiser and Smith accession SA268 (P.G.Smith), Capsicum eximium A.T.Hunz accession Hawkes 3860 (J.G.Hawkes) and two interspecific F1 hybrids, C. baccatum SA219 x C. eximium Hawkes 3860 and C. baccatum Hawkes 6489 x C. cardenasii SA 268. The standard technique of horizontal gel electrophoresis was employed. The gel was cut into severa...

  3. Fifth international symposium on the natural radiation environment (NRE - V). Book of abstracts

    International Nuclear Information System (INIS)

    Most of the 219 contributions Are on radon (to a much lesser extent: thoron) and its daughter products in dwellings and in the environment; on corresponding measuring instruments and - methods; on measurements done; and on radiation doses to professional workers and to the public. The section heading give a fairly good account of the subject matters treated. Measurement Techniques and Metrology (Nrs 1-33); Exposure to Natural Radiation in Non-Domestic Environments (34-56); Natural Radionuclides and Transfer Pathways (57-107); Radioactivity and Radiation in the Human Environment (108-183); Health Effects of Natural Radiation (184-205); Industrially Modified Levels of Radiation Exposure (206-219). (Quittner)

  4. Self-Limited versus Delayed Resolution of Acute Inflammation: Temporal Regulation of Pro-Resolving Mediators and MicroRNA

    OpenAIRE

    Gabrielle Fredman; Yongsheng Li; Jesmond Dalli; Nan Chiang; Serhan, Charles N.

    2012-01-01

    Mechanisms underlying delays in resolution programs of inflammation are of interest for many diseases. Here, we addressed delayed resolution of inflammation and identified specific microRNA (miR)-metabolipidomic signatures. Delayed resolution initiated by high-dose challenges decreased miR-219-5p expression along with increased leukotriene B4 (5-fold) and decreased (~3-fold) specialized pro-resolving mediators, e.g. protectin D1. Resolvin (Rv)E1 and RvD1 (1 nM) reduced miR-219-5p in human mac...

  5. Monolithic Hybrid and Passive Mode-Locked 40GHz Quantum Dot Laser Diodes

    DEFF Research Database (Denmark)

    Thompson, M. G.; Larsson, David; Rae, A. R.;

    2006-01-01

    For the first time hybrid and passive mode-locking jitter performance is investigated in 40GHz quantum-dot mode-locked lasers. Record low passive mode-locking jitter of 219fs is presented, along with promising hybrid mode-locking results of 124fs.......For the first time hybrid and passive mode-locking jitter performance is investigated in 40GHz quantum-dot mode-locked lasers. Record low passive mode-locking jitter of 219fs is presented, along with promising hybrid mode-locking results of 124fs....

  6. Mortality due to injuries in Maputo City, Mozambique

    DEFF Research Database (Denmark)

    Nizamo, Hanifa; Meyrowitsch, Dan Wolf; Zacarias, Eugénio;

    2006-01-01

    Records of all registered deaths due to injuries maintained by the Legal Medicine Department in Maputo City for the period 1 January to 31 December 2000 were reviewed. Among the 1135 registered deaths, road traffic injuries accounted for the most common underlying cause of death (43.7%), followed...... by firearm discharge (8.7%) and burns (7.8%). For all deaths, skull fracture (21.9%), organ system injury (17.2%) and brain tissue injury (9.3%) were the most important intermediate causes of death and among the immediate causes of death acute anaemia (21.9%) was the most common followed by asphyxia (14...

  7. Resposta de plantas micropropagadas de abacaxizeiro à inoculação de bactérias diazotróficas em casa de vegetação Response of pineapple plantlets to inoculation with diazotrophic bacteria in greenhouse

    Directory of Open Access Journals (Sweden)

    Olmar Baller Weber

    2003-12-01

    Full Text Available O objetivo deste trabalho foi selecionar e avaliar bactérias diazotróficas isoladas de abacaxizeiro (Ananas comosus (L. Merril no desenvolvimento de cultivares micropropagadas da mesma espécie em casa de vegetação. Plantas da cultivar Perolera foram submetidas à inoculação com Asaia bogorensis (AB219 e cultivadas em tubetes, durante 145 dias, com as misturas: casca de arroz carbonizada, folha de carnaubeira triturada e vermicomposto; casca de arroz carbonizada, pó da casca do coco maduro e vermicomposto; casca de arroz carbonizada, vermiculita e vermicomposto. Plantas da cultivar Primavera receberam inóculos com o AB219 e bactérias relacionadas a Burkholderia cepacia (AB202 e AB213, enquanto plantas das cultivares Pérola e Smooth Cayenne receberam AB219 e AB213, sendo cultivadas, por 140 dias, em tubetes com a mistura de vermicomposto e vermiculita. A colonização dos abacaxizeiros pelas bactérias diazotróficas foi confirmada. As plantas da cultivar Perolera cresceram melhor em casca de arroz carbonizada, vermiculita e vermicomposto e responderam positivamente ao AB219. Já as plantas da cultivar Primavera não apresentaram resposta significativa à inoculação com AB219, AB202 e AB213. Houve incremento de 23,1% a 38,5% na matéria seca de raízes das plantas da cultivar Pérola na presença de AB213 e AB219, respectivamente. A presença de AB213 incrementou em 15,2% a matéria seca da parte aérea das plantas da cultivar Smooth Cayenne. Os resultados revelam a eficiência de bactérias diazotróficas na promoção do crescimento de abacaxizeiros.The objective of this work was to select and to evaluate isolates of diazotrophic bacteria associated to pineapple (Ananas comosus (L. Merril plants in the development of micropropagated plantlets of cultivars pineapple in greenhouse. Plantlets from the Perolera cultivar have been submitted to inoculation with Asaia bogorensis (AB219 and were cultivated during 145 days on the following

  8. Study of Neutron-Deficient $^{202-205}$Fr Isotopes with Collinear Resonance Ionization Spectroscopy

    CERN Document Server

    De Schepper, Stijn; Cocolios, Thomas; Budincevic, Ivan

    The scope of this master’s thesis is the study of neutron-deficient $^{202−205}$Fr isotopes. These isotopes are inside the neutron-deficient lead region, a region that has shown evidence of shape coexistence. For this thesis, this discussion is limited to the phenomenon where a low lying excited state has a different shape than the ground state. Shape coexistence is caused by intruder states. These are single-particle Shell Model states that are perturbed in energy due to the interaction with a deformed core. In the neutron-deficient lead region the main proton intruder orbit is the 3s$_{1/2}$orbit. When going towards more neutron-deficient isotopes, deformation increases. The $\\pi3s_{1/2}$orbit will rise in energy and will eventually become the ground state in odd- A bismuth (Z=83) isotopes. It is also observed in odd-A astatine (Z=85) isotopes, already in less neutron-deficient nuclei. The same phenomenon is expected to be present francium (Z=87) isotopes already at $^{199}$Fr. Although it is currently ...

  9. The biokinetics of alpha-particle emitting radiopharmaceuticals

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, D.M. [School of Chemistry, Cardiff Univ., Cardiff (United Kingdom); Duffield, J.R. [Faculty of Applied Sciences, Univ. of the West of England, Bristol (United Kingdom)

    2005-07-01

    The past two decades have seen wide interest in the application of alpha-particle emitting radionuclides for targeted endoradiotherapy and a large number of compounds labeled with {sup 211}At (T{sup 1}/{sub 2} 7.21 h), {sup 212}Bi (T{sup 1}/{sub 2} 1 h) or {sup 213}Bi (T{sup 1}/{sub 2} 0.78 h) have been studied. Knowledge of the biokinetic behaviour of such agents is important both for their optimal clinical exploitation and for general radiological protection purposes. Animal studies of the distribution and retention of {sup 211}At compounds, including ionic astatide, substituted aromatic compounds and labelled monoclonal antibodies, have provided new information on the biochemistry of astatine. With respect the thyroid gland the uptake of the astatide ion has been shown to be very much lower than that of the iodide ion. Less information is available for {sup 212}Bi-labelled radiopharmaceuticals. The available data for both {sup 211}At and {sup 212}Bi radiopharmaceuticals are reviewed. Cautious generic biokinetic models for inorganic and simple organic compounds of {sup 211}At and {sup 212}Bi; for [{sup 211}At]-, and [{sup 212}Bi]-biphosphonates and for [{sup 211}At]-, and [{sup 212}Bi]-monoclonal antibodies, are proposed for use in general radiological protection when compound-specific data are not available. (orig.)

  10. Combined effect of gefitinib ('Iressa', ZD1839) and targeted radiotherapy with {sup 211}At-EGF

    Energy Technology Data Exchange (ETDEWEB)

    Sundberg, Aasa Liljegren; Orlova, Anna; Gedda, Lars; Tolmachev, Vladimir; Carlsson, Joergen [Division of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, 751 85, Uppsala (Sweden); Almqvist, Ylva [Division of Radiology, Uppsala University, Uppsala (Sweden); Blomquist, Erik [Division of Oncology, Uppsala University, Uppsala (Sweden); Jensen, Holger J. [Department of Clinical Physiology and Nuclear Medicine, PET and Cyclotron Unit, Rigshospitalet, Copenhagen (Denmark)

    2003-10-01

    The EGFR-TKI (epidermal growth factor receptor tyrosine kinase inhibitor) gefitinib ['Iressa' (trademark of the AstraZeneca group of companies), ZD1839] increases the cellular uptake of radiolabelled epidermal growth factor (EGF). We investigated gefitinib treatment combined with astatine-211 EGF targeting in vitro using two cell lines expressing high levels of EGFR: A431 (sensitive to gefitinib) and U343MGaCl2:1 (resistant to gefitinib). In both cell lines, the uptake of {sup 211}At-EGF was markedly increased by concomitant treatment with gefitinib. Survival was investigated using both a clonogenic survival assay and a cell growth assay. Combined gefitinib and {sup 211}At-EGF treatment reduced the survival of U343 cells 3.5-fold compared with {sup 211}At-EGF alone. In A431 cells, {sup 211}At-EGF treatment resulted in very low survival, but combined treatment with gefitinib increased the survival by about 20-fold. These results indicate that combined treatment with gefitinib might increase the effect of ligand-mediated radionuclide therapy in gefitinib-resistant tumours and decrease the effect of such therapy in gefitinib-sensitive tumours. (orig.)

  11. Alpha particle emitters in medicine

    International Nuclear Information System (INIS)

    Radiation-induced cancer of bone, liver and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High dose rates at high LET, effectiveness under hypoxic conditions, and minimal expectancy of repair are additional advantages of alpha emitters over antibodies labeled with beta emitting radionuclides for cancer therapy. Cyclotron-produced astatine-211 (211At) and natural bismuth-212 (212Bi) have been proposed and are under extensive study in the United States and Europe. Radium-223 (223Ra) also has favorable properties as a potential alpha emitting label, including a short-lived daughter chain with four alpha emissions. The radiation dosimetry of internal alpha emitters is complex due to nonuniformly distributed sources, short particle tracks, and high relative specific ionization. The variations in dose at the cellular level may be extreme. Alpha-particle radiation dosimetry, therefore, must involve analysis of statistical energy deposition probabilities for cellular level targets. It must also account fully for nonuniform distributions of sources in tissues, source-target geometries, and particle-track physics. 18 refs., 4 figs

  12. Tumor Immunotargeting Using Innovative Radionuclides

    Directory of Open Access Journals (Sweden)

    Françoise Kraeber-Bodéré

    2015-02-01

    Full Text Available This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality.

  13. Development of Reagents for Application of At-211 to Targeted Radionuclide Therapy of Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D. Scott

    2011-12-23

    This grant covered only a period of 4 months as the major portion of the award was returned to DOE due to an award of funding from NIH that covered the same research objectives. A letter regarding the termination of the research is attached as the last page of the Final Report. The research conducted was limited due to the short period of this grant, but the results obtained in that period are outlined in the Final Report. The studies addressed in the research effort were directed at a problem that is of critical importance to the in vivo application of the alpha-particle emitting radionuclide At-211. That problem, low in vivo stability of many astatinated molecules, severely limits the use of At-211 in therapeutic applications. The advances sought in the studies were expected to expand the types of biomolecules that can be used as carriers of At-211, and provide improved in vivo targeting of the radiation dose compared with the dose delivered to normal tissue.

  14. Tumor immunotargeting using innovative radionuclides.

    Science.gov (United States)

    Kraeber-Bodéré, Françoise; Rousseau, Caroline; Bodet-Milin, Caroline; Mathieu, Cédric; Guérard, François; Frampas, Eric; Carlier, Thomas; Chouin, Nicolas; Haddad, Ferid; Chatal, Jean-François; Faivre-Chauvet, Alain; Chérel, Michel; Barbet, Jacques

    2015-01-01

    This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality. PMID:25679452

  15. SPECT assay of radiolabeled monoclonal antibodies. Progress report, September 1, 1992--August 24, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Jaszczak, R.J.

    1993-08-20

    The overall goal of this project is to improve the effectiveness of single photon emission computed tomography (SPECT) to image and quantify radiolabeled monoclonal antibodies. During the past year, we have made significant progress toward this goal, and this report summarizes that work. Our efforts have been mainly directed along three fronts. First, we have developed and tested new reconstruction methods including three-dimensional iterative algorithms that model non-uniform attenuation and distance-dependent detector response. Both fan beam and parallel beam collimator geometries have been modeled and novel ways of improving the efficiency of the computationally intensive methods have been introduced. Second, an ultra-high resolution, small field-of-view pinhole collimator has been constructed and evaluated. Reconstructed spatial resolution of 1 to 3 mm (FWHM) has been achieved in phantom scans with a useful field-of-view of 9 to 10 cm. Finally, we have investigated the ability of SPECT to image and quantify astatine-211 distributions. Reconstructed images of phantom data demonstrated quantitative accuracy to within 10% with proper attenuation and scatter compensation.

  16. Silver impregnated nanoparticles of titanium dioxide as carriers for {sup 211}At

    Energy Technology Data Exchange (ETDEWEB)

    Cedrowska, Edyta; Lyczko, Monika; Piotrowska, Agata; Bilewicz, Aleksander [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); Stolarz, Anna; Trcinska, Agnieszka [Warsaw Univ. (Poland). Heavy Ion Lab.; Szkliniarz, Katarzyna [Silesia Univ. Katowice (Poland). Inst. of Physics; Was, Bogdan [Polish Academy of Science, Cracow (Poland). Inst. of Nuclear Physics

    2016-08-01

    The {sup 211}At radioisotope exhibits very attractive nuclear properties for application in radionuclide therapy. Unfortunately use of {sup 211}At is limited, because astatine as the heaviest halogen forms weak bond with carbon atoms in the biomolecules which makes {sup 211}At bioconjugates unstable in physiological conditions. In our work we propose a new solution for binding of {sup 211}At which consists of using nanoparticles of titanium dioxide modified with silver atoms as carriers for {sup 211}At. Ag{sup +} cations have been absorbed on the nanometer-sized TiO{sub 2} particles (15 and 32 nm) through ion exchange process and were reduced in Tollens' reaction. The obtained TiO{sub 2}-Ag nanoparticles were labeled with {sup 211}At. It was found that labeling yields were almost quantitative under reducing conditions, while under oxidizing conditions they dropped to about 80%. The labeled nanoparticles exhibited very high stability in physiological salt, PBS buffer, solutions of peptides (0.001 M cysteine, 0.001 M glutathione) and in human blood serum. To make TiO{sub 2}/Ag nanoparticles well dispersed in water and biocompatible their surface was modified with a silane coupling agent containing poly(ethyleneglycol) molecules. The developed functionalization approach will allow us to attach biomolecules to the TiO{sub 2}/Ag surface.

  17. Nuclear and chemical data for life sciences

    International Nuclear Information System (INIS)

    Use of reactor produced radionuclides is popular in life sciences. However, cyclotron production of proton rich radionuclides are being more focused in recent times. These radionuclides have already gained attention in various fields, including life sciences, provided they are obtained in pure form. This article is a representative brief of our contributions in generating nuclear data for the production of proton rich radionuclides of terbium, astatine, technetium, ruthenium, cadmium, niobium, zirconium, rhenium, etc., which may have application in clinical, biological, agriculture studies or in basic research. The chemical data required to separate the product isotopes from the corresponding target matrix have been presented along with a few propositions of radiopharmaceuticals. It also emphasizes on the development of simple empirical technique, based on the nuclear reaction model analysis, to generate reliable nuclear data for the estimation of yield and angular distribution of emitted neutrons and light charged particles from light as well as heavy ion induced reactions on thick stopping targets. These data bear utmost important in radiation dosimetry. (author)

  18. Studies of Stable Octupole Deformations in the Radium Region

    CERN Multimedia

    2002-01-01

    The purpose of the present project is to locate and identify states in the atomic nuclei possessing stable pearshaped octupole deformation. Such states, formally related to the structures known in molecular physics, manifest themselves as families of parity doublets in odd nuclei.\\\\ \\\\ The best possibilities for observing stable octupole deformations are offered in the Ra-region. Both theoretical calculations and experimental indications support such expectations. Such indications are the non-observation of two-phonon octupole vibrational states in the ISOLDE studies of the even-even radium nuclei, and the reversed sign of the decoupling factor of the ground state band in |2|2|5Ra observed in the single-neutron transfer reactions. In order to establish the predicted strong E1 and E3-transitions between the parity doublets in odd nuclei with stable octupole deformations it is proposed to study conversion electrons in odd-mass francium radium and radon isotopes following the @b-decay of francium and astatine. \\...

  19. Alpha particle emitters in medicine

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, D.R.

    1989-09-01

    Radiation-induced cancer of bone, liver and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High dose rates at high LET, effectiveness under hypoxic conditions, and minimal expectancy of repair are additional advantages of alpha emitters over antibodies labeled with beta emitting radionuclides for cancer therapy. Cyclotron-produced astatine-211 ({sup 211}At) and natural bismuth-212 ({sup 212}Bi) have been proposed and are under extensive study in the United States and Europe. Radium-223 ({sup 223}Ra) also has favorable properties as a potential alpha emitting label, including a short-lived daughter chain with four alpha emissions. The radiation dosimetry of internal alpha emitters is complex due to nonuniformly distributed sources, short particle tracks, and high relative specific ionization. The variations in dose at the cellular level may be extreme. Alpha-particle radiation dosimetry, therefore, must involve analysis of statistical energy deposition probabilities for cellular level targets. It must also account fully for nonuniform distributions of sources in tissues, source-target geometries, and particle-track physics. 18 refs., 4 figs.

  20. [Christofer Herrmann. Kloster und Burg - die architektur des Deutschens Ordens im Pressen und Livland. In : Glaube, Macht und Pracht. GeistlicheGemeinschaften des Ostseeraums im Zeitalter der Backsteingotik] / Dennis Hortmuth

    Index Scriptorium Estoniae

    Hortmuth, Dennis

    2011-01-01

    Arvustus: Christofer Herrmann. Kloster und Burg - die Architektur des Deutschen Ordens in Preussen und Livland. In : Glaube, Macht und Pracht. GeistlicheGemeinschaften des Ostseeraums im Zeitalter der Backsteingotik (=Archäologie und Geschichte im Ostseeraum; Archaeology and History of the Baltic 6) Rahden : Verlag Marie Leidorf, 2009. S. 209-219. Saksa Ordu arhitektuurist Preisi- ja Liivimaal

  1. Prevalence of genes encoding pyrogenic toxin superantigens and exfoliative toxins among strains of Staphylococcus aureus isolated from blood and nasal specimens

    NARCIS (Netherlands)

    Becker, Karsten; Friedrich, Alexander W; Lubritz, Gabriele; Weilert, Maria; Peters, Georg; Von Eiff, Christof

    2003-01-01

    A total of 429 different Staphylococcus aureus isolates encompassing 219 blood isolates and 210 isolates taken from anterior nares were systematically searched by two multiplex PCR-DNA enzyme immunoassays (PCR-DEIA) for exfoliative toxin (ET) genes eta and etb, as well as for the classical members o

  2. An On-Line Computerized Personnel-Payroll Dream.

    Science.gov (United States)

    Francis, E. E.

    1979-01-01

    Niles Township School District 219, Skokie, Illinois, has rebuilt its personnel and payroll program. The new system provides a data bank for storage of any and all information required by both the personnel and payroll departments on each district employee. (Author/MLF)

  3. Religion and Pet Loss: Afterlife Beliefs, Religious Coping, Prayer and Their Associations with Sorrow

    Science.gov (United States)

    Lee, Sherman A.

    2016-01-01

    This study examined the relationship between religion and sorrow among a sample of 219 owners of deceased pets (the sample was predominantly comprised of white, female, educated Christians). The results indicated that the vast majority of the participants believed that their pets' souls reside in a better place and that they will reunite with them…

  4. 75 FR 74127 - In the Matter of the Review of the Designation of Islamic Movement of Uzbekistan (IMU and Other...

    Science.gov (United States)

    2010-11-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE In the Matter of the Review of the Designation of Islamic Movement of Uzbekistan (IMU and Other Aliases) as a Foreign Terrorist Organization Pursuant to Section 219 of the Immigration and Nationality Act, as...

  5. The Effect of Childhood Trauma on Later Psychological Adjustment

    Science.gov (United States)

    Browne, Caroline; Winkelman, Cecelia

    2007-01-01

    This study examined whether adult attachment and cognitive distortion mediate the relationship between childhood trauma and psychological adjustment. The participants were 219 students (40 men and 117 women) enrolled in a university degree. Participants completed the Childhood Trauma Questionnaire, which assessed retrospective accounts of…

  6. Cognitive and Adaptive Functioning in 28 Girls with Rett Syndrome. Brief Report.

    Science.gov (United States)

    Perry, Adrienne; And Others

    1991-01-01

    This study of 28 girls (ages 2-19) with Rett Syndrome found profound handicaps in the intellectual and adaptive areas, according to standardized tests. Subjects seemed capable of learning some self-help skills at a basic level. The Cattell Mental Age was significantly negatively correlated with chronological age. (JDD)

  7. File list: His.Liv.10.AllAg.Liver [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.Liv.10.AllAg.Liver mm9 Histone Liver Liver SRX591723,SRX591725,SRX591727,SRX219...0338,SRX100343 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.Liv.10.AllAg.Liver.bed ...

  8. Characteristics of Absenteeism in Nursing Home Staff.

    Science.gov (United States)

    Cohen-Mansfield, Jiska; Rosenthal, Alvin S.

    This study investigated factors associated with absenteeism among nursing staff (N=219) at a long-term care facility. Four absenteeism measures were calculated from personnel records for each month of the year: no pay (the sum of unscheduled, unpaid sick, and leave without pay), part day (the sum of arrived late and left early), paid sick, and…

  9. 75 FR 27200 - Amateur Service Rules

    Science.gov (United States)

    2010-05-14

    ...., primary or secondary services), the basic principle is the equality of right to operate. Accordingly... harmful interference to, and must accept interference from, international broadcast stations whose...: (i) The FCC in the Automated Maritime Telecommunications System (AMTS), the 218-219 MHz Service,...

  10. 47 CFR 97.303 - Frequency sharing requirements.

    Science.gov (United States)

    2010-10-01

    ... right to operate. Accordingly, stations of each service in one Region or sub-Region must operate so as... MHz segment must not cause harmful interference to, and must accept interference from, international... authorized by: (i) The FCC in the Automated Maritime Telecommunications System (AMTS), the 218-219...

  11. Obesity and Socioeconomic Status in Children and Adolescents: United States, 2005-2008. NCHS Data Brief. Number 51

    Science.gov (United States)

    Ogden, Cynthia L.; Lamb, Molly M.; Carroll, Margaret D.; Flegal, Katherine M.

    2010-01-01

    In 2007-2008 almost 17% of children and adolescents aged 2-19 years were obese. Childhood obesity often tracks to adulthood and, in the short run, childhood obesity can lead to psychosocial problems and cardiovascular risk factors such as high blood pressure, high cholesterol, and abnormal glucose tolerance or diabetes. Studies have suggested that…

  12. Family Engagement in Literacy Activities: Revised Factor Structure for the Familia--An Instrument Examining Family Support for Early Literacy Development

    Science.gov (United States)

    Buhs, Eric S.; Welch, Greg; Burt, Jennifer; Knoche, Lisa

    2011-01-01

    This study evaluated a data-set drawn using "The Familia"--a measure originally developed to evaluate shared-reading activities. A newly developed set of conceptual supports and a confirmatory factor analysis (CFA) were applied to a new factor structure/model. Data were drawn from 219 young children and their families (mean age = 43 months)…

  13. Data of evolutionary structure change: 1ALCA-1VEDA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1ALCA-1VEDA 1ALC 1VED A A KQFTKCELSQNL--YDIDGYGRIALPELICTMFHTSGYD...CA 233 THR CA 295 GLU CA 388 TYR CA 428 1VED... A 1VEDA ASP CA 290 1VED A 1VED... CA 249 GLU CA 193 GLN CA 219 TRP CA 312 1VED

  14. More Abstracts on Effects of Radiation on Electronic Devices

    Science.gov (United States)

    Bouquet, Frank L.

    1987-01-01

    Second volume of bibliography summarizes literature on radiation effects on new electronic devices. Includes those of protons, electrons, neutrons, gamma rays, and cosmic rays at energies up to about 20 GeV. Volume contains 219 abstracts from unclassified sources. Organized into four sections: dose-rate effects, new technology, post-irradiaton effects, and test environments.

  15. Comparative analysis of genome-wide divergence, domestication footprints and genome-wide association study of root traits for Gossypium hirsutum and Gossypium barbadense

    Science.gov (United States)

    Use of 10,129 singleton SNPs of known genomic location in tetraploid cotton provided unique opportunities to characterize genome-wide diversity among 440 Gossypium hirsutum and 219 G. barbadense cultivars and landrace accessions of widespread origin. Using genome-wide distributed SNPs, we examined ...

  16. Prevalence and heterogeneity of Hemolysin gene vhh among hatchery isolates of Vibrio harveyi in India

    Digital Repository Service at National Institute of Oceanography (India)

    Parvathi, A.; George, J.; Kumar, S.

    :1239-1247. 11    12. Defoirdt T, Boon N, Sorgeloos P, Verstraete W, Bossier P (2008) Quorum sensing and quorum quenching in Vibrio harveyi:lessons learned from in vivo work. The ISME J 2:19–26 13. Fukui Y, Sawabe T (2007) Improved one-step colony PCR...

  17. InterProScan Result: FS871990 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available N 8.7e-117 T IPR008826 Selenium-binding protein Molecular Function: selenium binding (GO:0008430) ... ...FS871990 FS871990_6_ORF1 8FA219BDCFB30DBF PANTHER PTHR23300 SELENIUM-BINDING PROTEI

  18. AcEST: DK945209 [AcEST

    Lifescience Database Archive (English)

    Full Text Available 2.19 [Nov-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, ...length - Score (bit) - E-value - Report BLASTX 2.2.19 [Nov-02-2008] Reference: Altschul, Stephen F., Thoma

  19. AcEST: DK947237 [AcEST

    Lifescience Database Archive (English)

    Full Text Available it) - E-value - Report BLASTX 2.2.19 [Nov-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejan...2.19 [Nov-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang,

  20. AcEST: DK947690 [AcEST

    Lifescience Database Archive (English)

    Full Text Available .2.19 [Nov-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang,... length - Score (bit) - E-value - Report BLASTX 2.2.19 [Nov-02-2008] Reference: Altschul, Stephen F., Thom...as L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and D

  1. What Proportion of Preschool-Aged Children Consume Sweetened Beverages?

    Science.gov (United States)

    Nickelson, Jen; Lawrence, Jeannine C.; Parton, Jason M.; Knowlden, Adam P.; McDermott, Robert J.

    2014-01-01

    Background: Obesity affects nearly 17% of US children and youth 2-19?years old and 10% of infants and toddlers under the age of 2?years. One strategy for addressing obesity is to discourage sugar-sweetened beverage (SSB) consumption. Compared with their older school-aged counterparts, children =5?years depend largely on parents for the purchase…

  2. Board Members' Views on Training and Development.

    Science.gov (United States)

    Weaver, Liz; Inglis, Sue

    1999-01-01

    A survey of 22 agency directors and 219 volunteer board members showed that 40% of members received 1-5 hours of training in the last 6 months, 47% none. Training needs included board roles and responsibilities, strategic planning, understanding the agency, and fundraising. Preferred methods were facilitated workshop/retreat or board-led training…

  3. 77 FR 57079 - National Board for Education Sciences; Meeting

    Science.gov (United States)

    2012-09-17

    ... National Board for Education Sciences; Meeting AGENCY: Institute of Education Sciences, Department of... agenda of an upcoming meeting of the National Board for Education Sciences. The notice also describes the...:(202) 219-1466; email: Monica.Herk@ed.gov . SUPPLEMENTARY INFORMATION: The National Board for...

  4. What Do Employers Ask for in Advertisements for Special Education Positions?

    Science.gov (United States)

    Stephenson, Jennifer; Carter, Mark

    2014-01-01

    Although qualified special educators are more likely to provide effective teaching for students with disabilities and special education needs, it seems many teachers in special education and support positions are not qualified for this role. The study reported here provided analysis of 219 job advertisements for special education positions in…

  5. 16 CFR 1512.5 - Requirements for braking system.

    Science.gov (United States)

    2010-01-01

    ... highest gear ratio at a pedal crank rate of 60 revolutions per minute), 3 the stopping distance shall be 4...) or greater (in its highest gear ratio at a pedal crank rate of 60 revolutions per minute), 3 the... gear development greater than 6.67 m (21.9 ft) in the bicycle's highest gear ratio. Gear development...

  6. The Division III Student-Athlete: Academic Performance, Campus Involvement and Growth.

    Science.gov (United States)

    Richard, Shaunette; Aries, Elizabeth

    1999-01-01

    A study of 219 seniors, including a broad spectrum of student-athletes, at a Division III school revealed that athletic participation did not impede academic success, or prevent involvement in most other extracurricular activities or with nonathletes. Athletes' personal growth was positively related to time spent with teammates in games and…

  7. 48 CFR 1819.7302 - NASA contract clauses.

    Science.gov (United States)

    2010-10-01

    ... ADMINISTRATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Small Business Innovation Research (SBIR) and Small... I contracts awarded under the Small Business Innovation Research (SBIR) Program established pursuant to Public Law 97-219 (the Small Business Innovation Development Act of 1982). (b)...

  8. The Influence of Celebrity Exemplars on College Students' Smoking

    Science.gov (United States)

    Yoo, Woohyun

    2016-01-01

    Objective: This study examined the effect of celebrity smoking exemplars in health news on college students' perceptions of smoking-related health risks and smoking intentions. Participants and Methods: The data were collected using a Web-based survey of 219 undergraduate students at a large midwestern university in March 2011. Separate analyses…

  9. 75 FR 13422 - Federal Acquisition Regulation; FAR Case 2008-015, Payments Under Fixed-Price Architect-Engineer...

    Science.gov (United States)

    2010-03-19

    ... services work. Discussion and Analysis A proposed rule was published in the Federal Register at 74 FR 20666... Federal Acquisition Regulation; FAR Case 2008-015, Payments Under Fixed-Price Architect-Engineer Contracts.... Suzanne Neurauter, Procurement Analyst, at 202-219-0310. For information pertaining to status...

  10. Development and validation of a prognostic model for recurrent glioblastoma patients treated with bevacizumab and irinotecan

    DEFF Research Database (Denmark)

    Urup, Thomas; Dahlrot, Rikke Hedegaard; Grunnet, Kirsten;

    2016-01-01

    . MATERIAL AND METHODS: A total of 219 recurrent GBM patients treated with BEV plus irinotecan according to a previously published treatment protocol were included in the initial population. Prognostic models were generated by means of multivariate logistic and Cox regression analysis. RESULTS: In...

  11. AcEST: BP920856 [AcEST

    Lifescience Database Archive (English)

    Full Text Available sphatase OS=Streptococcus... 33 0.59 sp|A0JNC4|ELOV7_BOVIN Elongation of very long chain fatty acids ... 30 ...TH 219 R Q E VTH Sbjct: 136 RRHQGVEPQVTH 147 >sp|A0JNC4|ELOV7_BOVIN Elongation of very long chain fatty acid

  12. 48 CFR 1219.812 - Contract administration.

    Science.gov (United States)

    2010-10-01

    ... to 15 U.S.C. 637(a) (21). These contracts contain the clause at (TAR) 48 CFR 1252.219-71, Section 8(a... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract administration... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Contracting with the Small Business Administration (The...

  13. 48 CFR 19.1407 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clauses. 19.1407... PROGRAMS SMALL BUSINESS PROGRAMS Service-Disabled Veteran-Owned Small Business Procurement Program 19.1407 Contract clauses. The contracting officer shall insert the clause 52.219-27, Notice of Total...

  14. 48 CFR 19.1104 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clause. 19.1104... PROGRAMS SMALL BUSINESS PROGRAMS Price Evaluation Adjustment for Small Disadvantaged Business Concerns 19.1104 Contract clause. Insert the clause at 52.219-23, Notice of Price Evaluation Adjustment for...

  15. 48 CFR 1319.811-3 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1319.811... PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (the 8(a) Program) 1319.811-3 Contract clauses. (a) The contracting officer shall insert the clause 1352.219-70, Section...

  16. 48 CFR 1019.811-3 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1019.811... PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (The 8(a) Program) 1019.811-3 Contract clauses. (d)(3) Insert theclause at DTAR 1052.219-18, Notification of...

  17. 48 CFR 819.709 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... PROGRAMS SMALL BUSINESS PROGRAMS The Small Business Subcontracting Program 819.709 Contract clause. The contracting officer shall insert VAAR clause 852.219-9, Small Business Subcontracting Plan Minimum... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause....

  18. 48 CFR 19.811-3 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clauses. 19.811-3... PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (the 8(a) Program) 19.811-3 Contract clauses. (a) The contracting officer shall insert the clause at 52.219-11, Special...

  19. 48 CFR 19.1308 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clauses. 19.1308... PROGRAMS SMALL BUSINESS PROGRAMS Historically Underutilized Business Zone (HUBZone) Program 19.1308 Contract clauses. (a) The contracting officer shall insert the clause 52.219-3, Notice of Total HUBZone...

  20. Performance of Hamamatsu 64-anode photomultipliers for use with wavelength--shifting optical fibres

    CERN Document Server

    Tagg, N; Weber, A; Cabrera, A; Miyagawa, P S; Barker, M A; Lang, K; Michael, D; Saakyan, R; Thomas, J

    2004-01-01

    Hamamatsu R5900-00-M64 and R7600-00-M64 photomultiplier tubes will be used with wavelength--shifting optical fibres to read out scintillator strips in the MINOS near detector. We report on measurements of the gain, efficiency, linearity, crosstalk, and dark noise of 232 of these PMTs, of which 219 met MINOS requirements.

  1. 75 FR 58348 - Revision of the Shoshone National Forest Land and Resource Management Plan

    Science.gov (United States)

    2010-09-24

    ... planning rule, commonly known as the 2000 planning rule, in the Federal Register (74 FR 242, pages 67059... accepted and considered. Authority: 16 U.S.C. 1600-1614; 36 CFR 219.35 [74 FR 67073- 67074]. Dated... Forest Service Revision of the Shoshone National Forest Land and Resource Management Plan AGENCY:...

  2. 78 FR 69814 - Revision of the Land Management Plan for El Yunque National Forest

    Science.gov (United States)

    2013-11-21

    ... 2012 Forest Planning Rule (36 CFR part 219), the planning process encompases three-stages: Assessment... Pedro Rios, Forest Planning Team Leader, at the address identified above, or by sending an email to...; ] DEPARTMENT OF AGRICULTURE Forest Service Revision of the Land Management Plan for El Yunque National...

  3. 78 FR 23491 - National Forest System Land Management Planning; Correction

    Science.gov (United States)

    2013-04-19

    ... Forest Service 36 CFR Part 219 RIN 0596-AB86 National Forest System Land Management Planning; Correction...-1104. FOR FURTHER INFORMATION CONTACT: Ecosystem Management Coordination staff's Planning Specialist... management plans (the planning rule). The National Forest Management Act (NFMA) at 16 U.S.C....

  4. The Relationship between Sensation-Seeking and Eysenck's Dimensions of Personality.

    Science.gov (United States)

    Eysenck, Sybil; Zuckerman, Marvin

    1978-01-01

    The Eysenck Personality Questionnaire (EPQ) and the Sensation-Seeking Scale were administered to 219 American undergraduates and 879 English twins. Sensation-seeking was positively correlated to EPQ-measured traits of extraversion and psychoticism. There was no relationship between sensation-seeking and the trait dimension of neuroticism.…

  5. Integrating Nutrition into the Physical Education Curriculum

    Science.gov (United States)

    Green, Heather L.

    2012-01-01

    Obesity among children and teens continues to be a major public health concern in the United States. Approximately 16.9% of children and adolescents age 2-19 years are obese. To address this epidemic, schools have been encouraged to develop a coordinated school health program, which includes an interdisciplinary approach to nutrition education.…

  6. File list: Oth.Dig.50.VSV-G.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Dig.50.VSV-G.AllCell hg19 TFs and others VSV-G Digestive tract SRX961218,SRX961...219 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.Dig.50.VSV-G.AllCell.bed ...

  7. File list: Oth.Dig.20.VSV-G.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Dig.20.VSV-G.AllCell hg19 TFs and others VSV-G Digestive tract SRX961218,SRX961...219 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.Dig.20.VSV-G.AllCell.bed ...

  8. File list: Oth.Dig.05.VSV-G.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Dig.05.VSV-G.AllCell hg19 TFs and others VSV-G Digestive tract SRX961218,SRX961...219 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.Dig.05.VSV-G.AllCell.bed ...

  9. File list: Oth.Dig.10.VSV-G.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Dig.10.VSV-G.AllCell hg19 TFs and others VSV-G Digestive tract SRX961218,SRX961...219 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.Dig.10.VSV-G.AllCell.bed ...

  10. Main: AMMORESIIUDCRNIA1 [PLACE

    Lifescience Database Archive (English)

    Full Text Available AMMORESIIUDCRNIA1 S000374 31-Jul-2001 (last modified) uchi Motifs (IIU and IID) fou...nd in the Chlamydomonas (C.R.) Nia1 gene promoter; Involved in ammonium-response; Located between -231 and -...219 and also between -76 and -65; Involved in Nia1 transcription activation; W=T/A; nitrate reductase; ammonium response; Chlamydomonas reinhardtii GGWAGGGT ...

  11. A Comparison Study of United States and African Students on Perceptions of Obesity and Thinness.

    Science.gov (United States)

    Cogan, Jeanine C.; And Others

    1996-01-01

    College students in Ghana (n=349) and the United States (n=219) completed questionnaires about perceptions about weight, dieting, and ideal bodies. Students in Ghana were more accepting of large body size. Findings illustrated that perceptions of ideal body size and corresponding behaviors are influenced by culture and gender. (SLD)

  12. Ozarenije, ili lesnitsa, vedushtshaja k ikone / Valentina Siig

    Index Scriptorium Estoniae

    Siig, Valentina

    2007-01-01

    Ikooninäitus "Õigeusklik ikoon Eestis" Vene kultuurikeskuse galeriis Tallinnas, eksponeeritud 18-20. sajandist 97 ikooni. Näituse külastatavusest. Ikoonimaalija Aleksandr Balajevi (1947) eluloost, maalitud ikoonidest. Ill. lk. 217 ja 219 kunstniku 7 ikooni

  13. Aleksander Tassa arhiiv ootab uurijaid / Anne Untera

    Index Scriptorium Estoniae

    Untera, Anne, 1951-

    2008-01-01

    Aleksander Tassale (1882-1955) pühendatud kunstinäitus Kristjan Raua majamuuseumis kuni 29. III, teabepäev 27. II. Aleksander Tassa elutööst kunstniku, kirjaniku, kunsti uurija ja muuseumitöötajana (ERM, EKM), Pallase kunstiühingu asutaja ja juhina jm. Aleksander Tassa arhiivist Eesti Kirjandusmuuseumis (EKLA, F 219)

  14. Sociocultural Influences on Body Image Concerns of Young Chinese Males

    Science.gov (United States)

    Jackson, Todd; Chen, Hong

    2008-01-01

    This research assessed the extent to which sociocultural factors implicated in explanations of weight dissatisfaction among young Western females extend to sources of body image concern in emerging adult and adolescent males from the People's Republic of China. In Study 1, 219 Mainland Chinese male university students completed measures of stature…

  15. AcEST: DK962281 [AcEST

    Lifescience Database Archive (English)

    Full Text Available 0_BAMOL UDP-glucose dehydrogenase OS=Bambusa oldh... 219 8e-56 tr|Q84TT8|Q84TT8_COLES UDP-glucose dehydrogenase OS=Colocasia...LTEWDEFKTLDYKKIYDNMQKPAFLFDGRNVIDPEKLREIGFIVYSIGKPLDPWLKDMPA 478 >tr|Q84TT8|Q84TT8_COLES UDP-glucose dehydrogenase OS=Colocasia

  16. THE SCHOOL ADMINISTRATOR AND ORGANIZATIONAL CHARACTER.

    Science.gov (United States)

    MINER, JOHN B.

    TO DETERMINE MAJOR FACTORS AFFECTING SELECTION AND PERFORMANCE OF SUPERVISORS IN SCHOOL ORGANIZATIONS, DATA WERE ANALYZED FROM A SCHOOL ADMINISTRATOR EVALUATION FORM FOR 219 ADMINISTRATIVE PERSONNEL (79.3 PERCENT OF 276 TOTAL), REPRESENTING LARGE CITY, MEDIUM CITY, SMALL CITY, AND CONSOLIDATED SCHOOL DISTRICTS IN THE PACIFIC NORTHWEST. APPLYING…

  17. Nonlinear Quality of Life Index

    CERN Document Server

    Zinovyev, A

    2010-01-01

    This paper includes supplementary material for the paper [A.N. Gorban, A. Zinovyev, Principal manifolds and graphs in practice: from molecular biology to dynamical systems, International Journal of Neural Systems 20 (3) (2010), 219-232. E-print: arXiv:1001.1122 [cs.NE

  18. Lightcurve and Rotation Period Determination for 2616 Lesya and (28910) 2000 NH11

    Science.gov (United States)

    Salvaggio, Fabio; Franco, Lorenzo; Marchini, Alessandro; Papini, Riccardo

    2016-04-01

    Photometric observations of the main-belt asteroids 2616 Lesya and (28910) 2000 NH11 were made in 2015 December. For 2616 Lesya, analysis found a bimodal lightcurve with a period of 9.219 ± 0.001 h. For (28910) 2000 NHA, the result was a bimodal lightcurve with a period of 5.970 ± 0.002 h.

  19. 78 FR 15969 - Request for Nominations to Serve on Board of Trustees for the Cobell Education Scholarship Fund

    Science.gov (United States)

    2013-03-13

    ... to lizzie_marsters@ios.doi.gov . FOR FURTHER INFORMATION CONTACT: Lizzie Marsters, Chief of Staff to the Deputy Secretary, at lizzie_marsters@ios.doi.gov or call 202-219-7499. SUPPLEMENTARY INFORMATION...., Room 6118, Washington, DC 20240 or email to lizzie_marsters@ios.doi.gov . Dated: March 7, 2013....

  20. 78 FR 23283 - Request for Nominations To Serve on Board of Trustees for the Cobell Education Scholarship Fund

    Science.gov (United States)

    2013-04-18

    ... to lizzie_marsters@ios.doi.gov . FOR FURTHER INFORMATION CONTACT: Lizzie Marsters, Chief of Staff to the Deputy Secretary, at lizzie_marsters@ios.doi.gov or call 202-219-7499. SUPPLEMENTARY INFORMATION..., Washington, DC 20240 or email to lizzie_marsters@ios.doi.gov . Dated: April 15, 2013. David J. Hayes,...

  1. 48 CFR 52.244-6 - Subcontracts for Commercial Items.

    Science.gov (United States)

    2010-10-01

    ... clauses in subcontracts for commercial items: (i) 52.203-13, Contractor Code of Business Ethics and... Recovery Act. (iii) 52.219-8, Utilization of Small Business Concerns (MAY 2004) (15 U.S.C. 637(d)(2) and (3... subcontracts to small business concerns) exceeds $650,000 ($1.5 million for construction of any public...

  2. A Cross-Cultural Analysis of Interpersonal Needs.

    Science.gov (United States)

    Cambra, Ronald E.; Klopf, Donald W.

    The Fundamental Interpersonal Relations Orientation--Behavior (FIRO-B) was administered to 504 Japanese, 219 Australian, 73 Korean, and 397 United States college students to assess interpersonal needs in the four cultures. The FIRO-B provides ratings for inclusion, control, and affection needs on an "expressed" dimension to indicate the behavior…

  3. Further Validation of the Iowa Sleep Disturbances Inventory

    Science.gov (United States)

    Koffel, Erin

    2011-01-01

    This study examined the reliability and validity of an expanded version of the Iowa Sleep Disturbances Inventory (ISDI; Koffel & Watson, 2010) in 2 samples (219 college students and 200 psychiatric patients). The expanded ISDI includes the scales Sleep Paralysis and Sleep Hallucinations. These scales, along with the Nightmares scale, help define a…

  4. Long-Run Impact of the Thirty Cent Revision in Ontario's Minimum Wage on Five Industries.

    Science.gov (United States)

    McKenna, Ian B.

    To determine the effect of a legislated increase in the minimum wage in Ontario, 219 establishments in five industries were surveyed. The industries were shoe factories; luggage, handbag, and small leather goods manufacturers; hosiery mills, children's clothing industry; and the foundation garment industry. Data were gathered at three different…

  5. Merula Javanica (Horse.) and M. fumida (S. Müll.) two distinct species

    NARCIS (Netherlands)

    Finsch, O.

    1899-01-01

    Seeb. Cat. Br. M. V, 1881, p. 279 (part. only spec. a, b, c Types). id. Ibis 1893, p. 219 (Note). Owing to the incorrect diagnosis given by Horsfield 1) of his » Tardus javanicus it would be impossible to refer on this species at all, if not, fortunately, the types were preserved in the Collection o

  6. 78 FR 26069 - Top RX Pharmacy; Decision and Order

    Science.gov (United States)

    2013-05-03

    .../Pharmacy Nos. 219 and 5195, 77 FR 62316, 62317-22 (2012). Order Pursuant to the authority vested in me by... Weir Battershell, 76 FR 44359, 44368 n.27 (2011), for the proposition that ``although a registrant's... the public interest. See 76 FR at 44368 n.27. Thus, evidence of non-compliance with provisions of...

  7. Palmyra Atoll Site 15P 3/31/2004 89-90M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Palmyra Atoll, site 15P (05 52.219N, 162 02.697W), between 89 and 90 meters along a permanent transect.

  8. 50 CFR 300.222 - Prohibitions.

    Science.gov (United States)

    2010-10-01

    ... United States, including any laws related to carrying vessel observers or the operation of VMS units, as... install, activate, or operate a VMS unit as required in § 300.219(c). (l) In the event of VMS unit failure or interruption, fail to repair or replace a VMS unit, fail to notify the SAC and follow...

  9. Partnered Decisions? U.S. Couples and Medical Help-Seeking for Infertility

    Science.gov (United States)

    Johnson, Katherine M.; Johnson, David R.

    2009-01-01

    We examined male partners' influence on the decision to seek medical help for infertility using the National Study of Fertility Barriers. Building upon an existing help-seeking framework, we incorporated characteristics of both partners from 219 heterosexual couples who had ever perceived a fertility problem. In logistic regression analyses, we…

  10. 77 FR 31347 - Tennessee Gas Pipeline Company, L.L.C.; Notice of Availability of the Environmental Assessment...

    Science.gov (United States)

    2012-05-25

    ... markets in Ohio and Tennessee. \\1\\ A pipeline loop is a segment of pipe constructed parallel to an... stations to provide bi-directional natural gas flow: Station 219 in Mercer County, Station 303 in Venango... encourages electronic filing of comments and has expert staff available to assist you at (202) 502-8258...

  11. Drug: D02107 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available Indiclor (TN) InCl3 219.8104 221.177 D02107.gif Radioactive agent Therapeutic category: 4300 Therapeutic category of drugs... in Japan [BR:br08301] 4 Agents affecting cellular function 43 Radioactive drugs 430 Radioactive drugs... 4300 Radioactive drugs D02107 Indium (111In) chloride injection (JP16);

  12. Resources for Increasing Physical Activity in Children and Youth

    Science.gov (United States)

    Ryan, Carol A.; Beighle, Aaron

    2010-01-01

    The number of children and youth who are overweight has reached epidemic proportions in the United States. According to the 2007-2008 National Health and Nutrition Examination Survey (NHANES) conducted by the Centers for Disease Control and Prevention (CDC), an estimated 17 percent of children and adolescents ages 2-19 years are obese. In…

  13. 78 FR 69927 - In the Matter of the Review of the Designation of the Kurdistan Worker's Party (and Other Aliases...

    Science.gov (United States)

    2013-11-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE In the Matter of the Review of the Designation of the Kurdistan Worker's Party (and Other Aliases) as a Foreign Terrorist Organization Pursuant to Section 219 of the Immigration and Nationality Act, as Amended Based...

  14. 75 FR 13265 - Request for Public Comment on Maintenance of Expenditure (MOE) Proposed Policy as Amended on 2-19-10

    Science.gov (United States)

    2010-03-19

    ... COMMISSION Request for Public Comment on Maintenance of Expenditure (MOE) Proposed Policy as Amended on 2-19.... SUMMARY: The EAC seeks public comment on a Maintenance of Expenditure (MOE) Proposed Policy as Amended on.... SUPPLEMENTARY INFORMATION: The following is the complete text of the Maintenance of Expenditure (MOE)...

  15. AcEST: DK953538 [AcEST

    Lifescience Database Archive (English)

    Full Text Available FVHVLRERHEV 219 >sp|Q6P7K0|CMBL_XENTR Carboxymethylenebutenolidase homolog OS=Xenopus tropicalis GN=cmbl PE=...84 LEQVSLLEEKLKVHSKVDFQVKVFP 208 >sp|Q5XH09|CMBL_XENLA Carboxymethylenebutenolidase homolog OS=Xenopus laevis GN=cmb

  16. Association of ATP-Binding Cassette Transporter A1 Gene Polymorphisms in Type 2 Diabetes Mellitus among Malaysians

    Directory of Open Access Journals (Sweden)

    Polin Haghvirdizadeh

    2015-01-01

    Full Text Available Background. Type 2 diabetes mellitus (T2DM is a complex polygenic disorder characterized by impaired insulin resistance, insulin secretion, and dysregulation of lipid and protein metabolism with environmental and genetic factors. ATP-binding cassette transporter A1 (ABCA1 gene polymorphisms are reported as the one of the genetic risk factors for T2DM in various populations with conflicting results. This study was conducted based on PCR-HRM to determine the frequency of ABCA1 gene by rs2230806 (R219K, rs1800977 (C69T, and rs9282541 (R230C polymorphisms Malaysian subjects. Methods. A total of 164 T2DM and 165 controls were recruited and their genotypes for ABCA1 gene polymorphisms were determined based on the real time high resolution melting analysis. Results. There was a significant difference between the subjects in terms of age, BMI, FPG, HbA1c, HDL, LDL, and TG P<0.05. There was a significant association between HOM of R219K P=0.005, among Malaysian subjects; moreover, allele frequency revealed the significant difference in A allele of R219K P=0.003. But, there was no significant difference in genotypic and allelic frequencies of C69T and R230C polymorphism. Conclusion. R219K polymorphism of ABCA1 gene can be considered as a genetic risk factor for T2DM subjects among Malaysians.

  17. Escherichia coli rpiA gene encoding ribose phosphate isomerase A

    DEFF Research Database (Denmark)

    Hove-Jensen, Bjarne; Maigaard, Marianne

    1993-01-01

    was sequenced and shown to harbor an open reading frame of 219 codons, sufficient to encode a polypeptide with an Mr of 22,845. The synthesis of the rpiA-encoded polypeptide was detected by analysis of minicells, which established the subunit Mr as 27,000. The assignment of the correct reading frame...

  18. Flow-induced vibration of circular cylindrical structures

    Energy Technology Data Exchange (ETDEWEB)

    Chen, S.S.

    1985-06-01

    This report summarizes the flow-induced vibration of circular cylinders in quiescent fluid, axial flow, and crossflow, and applications of the analytical methods and experimental data in design evaluation of various system components consisting of circular cylinders. 219 figs., 30 tabs. (JDB)

  19. AcEST: DK948146 [AcEST

    Lifescience Database Archive (English)

    Full Text Available ne and TPR repeat-containing pr... 30 8.2 sp|A2R3F3|SHE9_ASPNC Sensitive to high expression protein 9 homo.....QLQPEQGAAYVTYGQTLARNGS 710 Query: 221 R 219 R Sbjct: 711 R 711 >sp|A2R3F3|SHE9_ASPNC Sensitive

  20. Validating a Measure of Teacher Intentions to Integrate Technology in Education in Turkey, Spain and the USA

    Science.gov (United States)

    Perkmen, Serkan; Antonenko, Pavlo; Caracuel, Alfonso

    2016-01-01

    The main purpose of this study was to examine the validity of the Teacher Intentions to Integrate Technology in Education Scale using pre-service teacher samples from three countries on three continents--Turkey, Spain and the United States. Study participants were 550 pre-service teachers from three universities in Turkey, Spain and the USA (219,…

  1. 48 CFR 215.304 - Evaluation factors and significant subfactors.

    Science.gov (United States)

    2010-10-01

    ... require use of the clause at FAR 52.219-9, Small Business Subcontracting Plan, other than those based on... extent to which offerors identify and commit to small business and historically black college or... addressing the extent of small business and historically black college or university and minority...

  2. 78 FR 59913 - Revision of the Land Management Plan for the Francis Marion National Forest

    Science.gov (United States)

    2013-09-30

    ... Forest Planning Rule (36 CFR Part 219), the planning process encompases three-stages: assessment, plan... second stage of the planning process, which is the development of the land management plan revision. The... the National Forest Management Act (NFMA) of 1976 describe the strategic direction for management...

  3. Domain Modeling: NP_787125.1 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_787125.1 chr13 Crystal Structure of Human Fibroblast Growth Factor Homologous Fa...ctor 2A (FHF2A), also referred to as Fibroblast Growth Factor 13A (FGF13A) p3hbwb_ chr13/NP_787125.1/NP_787125.1_apo_71-219.pdb blast 0 ...

  4. Factors that may facilitate or hinder a family-focus in the treatment of parents with a mental illness

    NARCIS (Netherlands)

    Lauritzen, C.; Reedtz, C.; Doesum, K.T.M. van; Martinussen, M.

    2015-01-01

    Children with mentally ill parents are at risk of developing mental health problems themselves. To enhance early support for these children may prevent mental health problems from being transmitted from one generation to the next. The sample (N = 219) included health professionals in a large univers

  5. 76 FR 13617 - Office of Federal High-Performance Green Buildings (OFHPGB); Notice of GSA Bulletin OFHPGB 2011...

    Science.gov (United States)

    2011-03-14

    ... ADMINISTRATION Office of Federal High-Performance Green Buildings (OFHPGB); Notice of GSA Bulletin OFHPGB 2011... of Federal High-Performance Green Buildings at (202) 219-1522. Please cite OFHPGB Bulletin 2011-OGP-1... can provide significant incentive for contractors to meet or exceed energy reduction requirements....

  6. Deviates' External Status and Opinion Patterns: Effects on Influence, Attractiveness, and Perceived Rationale.

    Science.gov (United States)

    Ruback, R. Barry; Gromme, Marcia A.

    1989-01-01

    Manipulated external status of a target by presenting person as ethnic majority female, ethnic minority male, or ethnic majority male discussing issue with four ethnic majority males. Subjects were college students (N=219). Results were consistent with previous research showing odd person in a group is more salient than other group members. (ABL)

  7. Flow-induced vibration of circular cylindrical structures

    International Nuclear Information System (INIS)

    This report summarizes the flow-induced vibration of circular cylinders in quiescent fluid, axial flow, and crossflow, and applications of the analytical methods and experimental data in design evaluation of various system components consisting of circular cylinders. 219 figs., 30 tabs

  8. European Bat Lyssaviruses, the Netherlands

    NARCIS (Netherlands)

    Poel, van der W.H.M.; Heide, van der R.; Verstraten, E.R.A.M.; Kramps, J.A.

    2005-01-01

    To study European bat lyssavirus (EBLV) in bat reservoirs in the Netherlands, native bats have been tested for rabies since 1984. For all collected bats, data including species, age, sex, and date and location found were recorded. A total of 1,219 serotine bats, Eptesicus serotinus, were tested, and

  9. 77 FR 38267 - Information Collection; Request for Comment; Objections to New Land Management Plans, Plan...

    Science.gov (United States)

    2012-06-27

    ... by Title 36, Code of Federal Regulations, Part 219-Planning, Subpart A-National Forest System Land... Deputy Chief, National Forest System. BILLING CODE 3410-11-P ... Forest Service Information Collection; Request for Comment; Objections to New Land Management Plans,...

  10. Hydrogeochemical and stream sediment reconnaissance data display and listing for the Marfa NTMS Quadrangle, Texas

    International Nuclear Information System (INIS)

    An abbreviated form of the HSSR Basic Data Report, consisting of field and laboratory data for 181 groundwater and 219 stream sediment samples, for the Marfa Quadrangle, Texas is presented. Detailed geochemical projects were previously reported for parts of the Marfa Quadrangle, therefore, reconnaissance samples were collected in areas not included in the detailed geochemical projects

  11. Domestic Abuse and Child Contact: Positioning Children in the Decision-Making Process

    Science.gov (United States)

    Holt, Stephanie

    2011-01-01

    Drawing on a three-year Irish research study, this paper focuses on the decision-making process in child contact, specifically the assessment and management of risk of continuing abuse to young people previously exposed to domestic abuse. A mixed methodological approach involved the completion of survey questionnaires by 219 mothers and the…

  12. 75 FR 28849 - Review of the Designation of Ansar al-Islam (aka Ansar Al-Sunnah and Other Aliases) as a Foreign...

    Science.gov (United States)

    2010-05-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Review of the Designation of Ansar al-Islam (aka Ansar Al-Sunnah and Other Aliases) as a Foreign Terrorist Organization Pursuant to Section 219 of the Immigration and Nationality Act, as Amended Based upon a review...

  13. Comorbidity of Migraine with ADHD

    Science.gov (United States)

    Fasmer, Ole Bernt; Riise, Trond; Lund, Anders; Dilsaver, Steven C.; Hundal, Oivind; Oedegaard, Ketil J.

    2012-01-01

    Objective: The purpose of this study was to investigate how often drugs used to treat migraine and ADHD are prescribed to the same patients to assess, indirectly, the comorbidity of these disorders. Method: We used data from the Norwegian prescription database for 2006, including the total Norwegian population (N = 4,640,219). Results:…

  14. Real world thirty-day mortality in female patients with acute myocardial infarction from Beijing

    Institute of Scientific and Technical Information of China (English)

    宋雷

    2013-01-01

    Objective To evaluate the gender differences on the short-term outcomes of patients with acute myocardial in-farction in the real world.Methods A total of 471 consecutive patients[male 368 (78.1%) and female103 (21.9%) ]with acute myocardial infarction<72 hours in cardiac care unit were included.The clinical data,

  15. Data of evolutionary structure change: 1ACPA-2DEVC [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1ACPA-2DEVC 1ACP 2DEV A C STIEERVKKIIGEQLGVKQEEVTNNASFVEDLGADSLDT...HHH EEE EEEEEEE EEEEEEEEEE -------- 0 1ACP... A 1ACPA EEAEK-----IT...> ARG CA 219 LYS CA 147 THR CA 173 1ACP... A 1ACPA ELVMALEEEFDT

  16. Engine Tune-Up Service. Unit 5: Fuel and Carburetion Systems. Student Guide. Automotive Mechanics Curriculum.

    Science.gov (United States)

    Goodson, Ludy

    This student guide is for Unit 5, Fuel and Carburetion Systems, in the Engine Tune-Up Service portion of the Automotive Mechanics Curriculum. It deals with inspecting and servicing the fuel and carburetion systems. A companion review exercise book and posttests are available separately as CE 031 218-219. An introduction tells how this unit fits…

  17. Studies on ageing and the severity of radiographic joint damage in rheumatoid arthritis

    NARCIS (Netherlands)

    Mangnus, Lukas; van Steenbergen, Hanna W.; Lindqvist, Elisabet; Brouwer, Elisabeth; Reijnierse, Monique; Huizinga, Tom W. J.; Gregersen, Peter K.; Berglin, Ewa; Rantapaa-Dahlqvist, Solbritt; van der Heijde, Desiree; van der Helm-van Mil, Annette H. M.

    2015-01-01

    Introduction: The western population is ageing. It is unknown whether age at diagnosis affects the severity of Rheumatoid Arthritis (RA), we therefore performed the present study. Method: 1,875 RA-patients (7,219 radiographs) included in five European and North-American cohorts (Leiden-EAC, Wichita,

  18. 77 FR 58828 - Northern Indiana Public Service Company; Notice of Petition for Declaratory Order

    Science.gov (United States)

    2012-09-24

    ... Expansion Plan process. \\1\\ 16 U.S.C. 824e, 824s(a) (2006). FPA Section 219 was added as part of the Energy...), appeal dismissed sub nom., Am. Pub. Power Ass'n. v. FERC, No. 07-1050, 2007 U.S.App. LEXIS 11908...

  19. Performance of Hamamatsu 64-anode photomultipliers for use with wavelength-shifting optical fibres

    International Nuclear Information System (INIS)

    Hamamatsu R5900-00-M64 and R7600-00-M64 photomultiplier tubes will be used with wavelength-shifting optical fibres to read out scintillator strips in the MINOS near detector. We report on measurements of the gain, efficiency, linearity, crosstalk, and dark noise of 232 of these PMTs, of which 219 met MINOS requirements

  20. A Cross-Cultural Study of Children's Perceptions of Selected Religious Concepts.

    Science.gov (United States)

    Nazar, Fatima; Kouzekanani, Kamiar

    2003-01-01

    A survey of 219 children from a kindergarten in the United States and a Kuwaiti kindergarten and Indian private preschool in Kuwait examined children's perceptions of God, death, and the afterlife. The common responses of the children suggest that although different views of Islam, Christianity, and Hinduism may appear contradictory, they are all…

  1. Investigation of a gas-catcher/ion guide system using alpha-decay recoil products

    Energy Technology Data Exchange (ETDEWEB)

    Peraejaervi, K. E-mail: kari.perajarvi@phys.jyu.fi; Huikari, J.; Rinta-Antila, S.; Dendooven, P

    2002-04-22

    {sup 219}Rn recoils from the alpha decay of {sup 223}Ra have been used to study the efficiency and delay time distributions of a gas-catcher/ion guide system. Ions with charge states up to +4 were coming out of the gas cell. Combining efficiency and delay time measurements, ion survival times in plasma free conditions can be deduced.

  2. Dicty_cDB: CHN835 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available tical) Pinus taeda cDNA clone NXRV120_G11 5', mRNA sequence. 48 0.22 1 BA000026 |BA...005344.13 Zebrafish DNA sequence from clone CH211-219E17. 40 0.097 2 BQ699205 |BQ699205.1 NXRV120_G11_F NXRV (Nsf Xylem Root wood Ver

  3. Management of upper gastrointestinal bleeding from portal hypertension: Elective or emergency operation?

    OpenAIRE

    Liu, Sen

    2014-01-01

    Objective : To evaluate the clinical outcome of emergency and elective operation of splenectomy with periesophagogastric devascularization in treating upper gastrointestinal hemorrhage resulted from portal hypertension. Methods : We retrospectively reviewed 219 patients of upper gastrointestinal hemorrhage resulted from portal hypertension treated using emergency or elective operation between Jul 2002 and Aug 2010. The clinical data were collected and analyzed. Results : In the group of elect...

  4. Effects of Welfare Participation on Marriage

    Science.gov (United States)

    Teitler, Julien O.; Reichman, Nancy E.; Nepomnyaschy, Lenna; Garfinkel, Irwin

    2009-01-01

    We investigated the widely held premise that welfare participation causes women to refrain from marriage. Using data from the Fragile Families and Child Wellbeing Study (N = 3,219), we employed an event history approach to study transitions to marriage among mothers who have had a nonmarital birth. We found that welfare participation reduces the…

  5. 36 CFR 228.102 - Leasing analyses and decisions.

    Science.gov (United States)

    2010-07-01

    ... at 43 CFR parts 1500-1508, and Forest Service implementing policies and procedures set forth in... accordance with the requirements of 36 CFR part 219 (Forest land and resource management planning) and/or, as... there is significant new information or circumstances as defined by 40 CFR 1502.9 requiring...

  6. 48 CFR 207.172 - Human research.

    Science.gov (United States)

    2010-10-01

    ... compliance with 32 CFR Part 219, Protection of Human Subjects; and (b) Must have a Human Research Protection... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Human research. 207.172... OF DEFENSE ACQUISITION PLANNING ACQUISITION PLANNING Acquisition Plans 207.172 Human research. Any...

  7. What Can We Learn from Toddlers about Categorical Perception of Color? Comments on Goldstein, Davidoff, and Roberson

    Science.gov (United States)

    Franklin, Anna; Wright, Oliver; Davies, Ian R. L.

    2009-01-01

    We comment on Goldstein, Davidoff, and Roberson's replication and extension ("Journal of Experimental Child Psychology, 102", 219-238 [2009]) of our study of the effect of toddlers' color term knowledge on their categorical perception (CP) of color ("Journal of Experimental Child Psychology, 90", 114-141 [2005]). First, we discuss how best to…

  8. Papel de las células NK y linfocitos T en la respuesta inmune frente a Chlamidophyla abortus en modelo murino / Carlos Manuel Martínez Cacéres; directores, Joaquín Sánchez Campillo, Antonio J. Buendía Marín y Jesús Salinas Lorente.

    OpenAIRE

    Martínez Cáceres, Carlos Manuel

    2006-01-01

    Tesis-Universidad de Murcia. Consulte la tesis en: BCA. GENERAL. ARCHIVO UNIVERSITARIO. T.M. 3026. Consulte la tesis en: BCA. GENERAL. Fac. Veterinaria. Departamentos. E002B TESIS 111. Consulte la tesis en: BCA. GENERAL. Fac. Veterinaria. Sala de estudio. Tesis-V 219.

  9. Longitudinal Models of Socio-Economic Status: Impact on Positive Parenting Behaviors

    Science.gov (United States)

    Azad, Gazi; Blacher, Jan; Marcoulides, George

    2014-01-01

    Parenting research is frequently conducted without a thorough examination of socio-economic characteristics. In this study, longitudinal observations of positive parenting were conducted across six time points. Participants were 219 mothers of children with and without developmental delays. Mothers' positive parenting increased during early…

  10. Pre-adolescent gender differences in associations between temperament, coping and mood

    NARCIS (Netherlands)

    G.M. de Boo; M. Spiering

    2010-01-01

    Relationships between temperament, coping, depressive and aggressive mood in 8-12-year-old boys (n = 185) and girls (n = 219) were investigated, with a focus on gender differences. Children completed two self-report questionnaires: the Early Adolescent Temperament Questionnaire-Revised and Children'

  11. 7 CFR 2.42 - Administrator, Farm Service Agency.

    Science.gov (United States)

    2010-01-01

    ...), except as delegated to the Under Secretary for Food, Nutrition, and Consumer Services in § 2.19 and to... and Consumer Service and the Agricultural Marketing Service in the procurement, handling, payment, and... Older Americans Act of 1965, as amended (42 U.S.C. 3030a), and section 4(a) of the Agriculture...

  12. Evaluating the Effectiveness of a School-Based Counselling Service in the UK

    Science.gov (United States)

    Fox, Claire L.; Butler, Ian

    2009-01-01

    Despite the growth of school counselling in the UK, very few studies have examined its effectiveness. As part of a wider evaluation of the work of the NSPCC Schools Counselling Project, 219 pupils aged 11-17 years completed the TEEN CORE questionnaire before receiving counselling; 104 of these pupils also completed a questionnaire after…

  13. The Geology of Chile

    OpenAIRE

    Cabrera, Lluís; Calafat, A.; Gimeno, D.; Liesa, M.; Proenza, J.; Sàbat, F.; Sáez, Alberto; Santanach, Pere

    2008-01-01

    6 páginas.-- Book review of "The Geology of Chile", by Teresa Moreno and Wes Gibbons (eds.) (2007). Geological Society. London (United Kingdom). 414 pages, 286 figures including maps, charts and pictures; 27, 5 x 21 cm, ISBN 978-1- 86239-219-9 (hardback) and ISBN 978-1-86239-220-5 (softback).

  14. Predictors of Summer Sun Safety Practice Intentions among Rural High School Students

    Science.gov (United States)

    Cho, Hyunyi; Sands, Laura P.; Wilson, Kari M.

    2010-01-01

    To investigate the association between theoretically grounded psychosocial motivators and the sun safety practice intentions of rural youth. Method: A survey was given to 219 members of FFA (Future Farmers of America) at high schools in the rural Midwest (average age = 16). Results: Perceived self-efficacy, peer norms, response efficacy, and…

  15. 77 FR 44307 - In the Matter of the Review of the Designation of the Islamic Resistance Movement (Hamas and...

    Science.gov (United States)

    2012-07-27

    ... terrorist organization have not changed in such a manner as to warrant revocation of the designation and... Matter of the Review of the Designation of the Islamic Resistance Movement (Hamas and Other Aliases) As a Foreign Terrorist Organization pursuant to Section 219 of the Immigration and Nationality Act, as...

  16. The quenched invariance principle for random walks in random environments admitting a bounded cycle representation

    OpenAIRE

    Deuschel, Jean-Dominique; Kösters, Holger

    2008-01-01

    We derive a quenched invariance principle for random walks in random environments whose transition probabilities are defined in terms of weighted cycles of bounded length. To this end, we adapt the proof for random walks among random conductances by Sidoravicius and Sznitman (Probab. Theory Related Fields 129 (2004) 219--244) to the non-reversible setting.

  17. Comparison of Qinzhou bay wetland landscape information extraction by three methods

    Directory of Open Access Journals (Sweden)

    X. Chang

    2014-04-01

    and OO is 219 km2, 193.70 km2, 217.40 km2 respectively. The result indicates that SC is in the f irst place, followed by OO approach, and the third DT method when used to extract Qingzhou Bay coastal wetland.

  18. Liver transplantation

    OpenAIRE

    Rodríguez-Perálvarez, M; De La Mata, M; Burroughs, A K

    2014-01-01

    Purpose of review: Long-term survival of liver transplant recipients is threatened by increased rates of de-novo malignancy and recurrence of hepatocellular carcinoma (HCC), both events tightly related to immunosuppression. Recent findings: There is accumulating evidence linking increased exposure to immunosuppressants and carcinogenesis, particularly concerning calcineurin inhibitors (CNIs), azathioprine and antilymphocyte agents. A recent study including 219 HCC transplanted patients sh...

  19. 49 CFR 175.10 - Exceptions for passengers, crewmembers, and air operators.

    Science.gov (United States)

    2010-10-01

    ... protective case in carry-on or checked baggage. (8) Small arms ammunition for personal use carried by a.... This paragraph does not apply to persons traveling under the provisions of 49 CFR 1544.219. (9) One... prevent unintentional functioning during transport. (15) A wheelchair or other battery-powered...

  20. 76 FR 24410 - Financial Crimes Enforcement Network; Comprehensive Iran Sanctions, Accountability, and...

    Science.gov (United States)

    2011-05-02

    ... Foreign Accounts, 71 FR 496 (Jan. 4, 2006). \\16\\ Anti-Money Laundering Requirements--Correspondent..., 67 FR 60562 (Sept. 26, 2002). \\17\\ Id. VII. Paperwork Reduction Act The collection of information... section 219(a) of the Immigration and Nationality Act (8 U.S.C. 1189(a)) or support for acts...

  1. Domain Modeling: NP_003411.3 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_003411.3 chr3 CRYSTAL STRUCTURE OF A DESIGNED ZINC FINGER PROTEIN BOUND TO DNA c1meyf_ chr3/NP_003411.3.../NP_003411.3_holo_219-301.pdb blast 224C,226V,227C,228G,229K,230G,231F,232S,233Q,234S

  2. Domain Modeling: NP_001561.3 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_001561.3 chr3 Structural Basis for the Interaction of TAK1 Kinase with its Activ...ating Protein TAB1 p2evaa_ chr3/NP_001561.3/NP_001561.3_holo_194-543.pdb psi-blast 216I,217S,218Q,219G,224V,

  3. Licorice consumption as a cause of posterior reversible encephalopathy syndrome : a case report

    NARCIS (Netherlands)

    van Beers, Eduard J; Stam, Jan; van den Bergh, Walter M

    2011-01-01

    INTRODUCTION: A 49-year-old woman was admitted to our hospital because of thunderclap headache and blurred vision. At the time of presentation, her blood pressure was 219/100 mmHg, her arterial pH was 7.64 and her potassium level was 2.7 mM/l. METHODS: The combination of sequential computed tomograp

  4. 77 FR 71163 - Federal Motor Vehicle Safety Standards; Windshield Zone Intrusion

    Science.gov (United States)

    2012-11-29

    ... longer necessary. \\1\\ 73 FR 38372. Our belief stemmed from the fact that FMVSS No. 219 had succeeded in... on State regulation. The consumer advocacy organizations and the insurance consortium did not support..., Mitsubishi, Porsche, Toyota, and Volkswagen. A. The Changing Vehicle Fleet Public Citizen/CAS stated,...

  5. 77 FR 55191 - Fishing Capacity Reduction Program for the Pacific Coast Groundfish Fishery

    Science.gov (United States)

    2012-09-07

    ... (69 FR 67100) proposing regulations to implement an industry fee system for repaying the reduction loan. The final rule was published July 13, 2005 (70 FR 40225) and fee collection began on September 8... National Oceanic and Atmospheric Administration RIN 0648-XC219 Fishing Capacity Reduction Program for...

  6. Regulations on the Management of Re- call of Defective Auto Products to be Implemented Next Year

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    On October 10, Regulations on the Manage- ment of Recall of Defective Auto Products was ap- proved to implement on January l, 2013 by No. 219 Executive Meeting of the State Council. The product quality supervision departments of the State Council are responsible for supervising and managing the recall of the national defective auto products.

  7. Extraction of radioactive positive ions across the surface of superfluid helium : A new method to produce cold radioactive nuclear beams

    NARCIS (Netherlands)

    Huang, WX; Dendooven, P; Gloos, K; Takahashi, N; Pekola, JP; Aysto, J

    2003-01-01

    Alpha-decay recoils Rn-219 were stopped in superfluid helium and positive ions were extracted by electric field into the vapour phase. This first quantitative observation of extraction was successfully conducted using highly sensitive radioactivity detection. The efficiency for extraction across the

  8. AcEST: DK947284 [AcEST

    Lifescience Database Archive (English)

    Full Text Available bit) - E-value - Report BLASTX 2.2.19 [Nov-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro....2.19 [Nov-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang,

  9. AcEST: BP920082 [AcEST

    Lifescience Database Archive (English)

    Full Text Available .2.19 [Nov-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang,...l, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J

  10. AcEST: DK946508 [AcEST

    Lifescience Database Archive (English)

    Full Text Available it) - E-value - Report BLASTX 2.2.19 [Nov-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro...2.19 [Nov-02-2008] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang,

  11. Analyzes of genome-wide association follow-up study for calving traits in dairy cattle

    DEFF Research Database (Denmark)

    Höglund, Johanna Karolina; Guldbrandtsen, Bernt; Lund, Mogens Sandø;

    2012-01-01

    nearly twice the sample size of other two subsets allowed the detection of far more significant associations than the two smaller subsets. The number of significant SNPs in REF (older bulls) was about four times higher compare to VAL (younger bulls) though both had similar sample sizes, 2,219 and 2...

  12. 77 FR 21791 - Proposed Flood Hazard Determinations

    Science.gov (United States)

    2012-04-11

    ..., North Haven, CT 06473. Bracken County, Kentucky, and Incorporated Areas Maps Available for Inspection Online at: http://www.bakeraecom.com/index.php/kentucky/bracken/ City of Augusta City Offices, 219 Main... of Bracken County. Bracken County Courthouse, 116 West Miami Street, Brooksville, KY 41004....

  13. Utility of the Rosenberg Self-Esteem Scale

    Science.gov (United States)

    Davis, Clare; Kellett, Stephen; Beail, Nigel

    2009-01-01

    The Rosenberg Self-Esteem Scale (RSES) continues to be used to purportedly measure self-esteem of people with intellectual disabilities, despite the lack of sound evidence concerning its validity and reliability when employed with this population. The psychometric foundations of the RSES were analyzed here with a sample of 219 participants with…

  14. Couples at risk following the death of their child : predictors of grief versus depression

    NARCIS (Netherlands)

    Wijngaards-de Meij, Leoniek; Stroebe, Margaret; Schut, Henk; Stroebe, Wolfgang; van den Bout, Jan; van der Heijden, Peter; Dijkstra, Iris

    2005-01-01

    This longitudinal study examined the relative impact of major variables for predicting adjustment (in terms of both grief and depression) among bereaved parents following the death of their child. Couples (N = 219) participated 6, 13, and 20 months postloss. Use of multilevel regression analyses ena

  15. Improving Alcohol Screening for College Students: Screening for Alcohol Misuse amongst College Students with a Simple Modification to the CAGE Questionnaire

    Science.gov (United States)

    Taylor, Purcell; El-Sabawi, Taleed; Cangin, Causenge

    2016-01-01

    Objective: To improve the CAGE (Cut down, Annoyed, Guilty, Eye opener) questionnaire's predictive accuracy in screening college students. Participants: The sample consisted of 219 midwestern university students who self-administered a confidential survey. Methods: Exploratory factor analysis, confirmatory factor analysis, receiver operating…

  16. Diagnosing Paroxysmal Atrial Fibrillation in Patients With Ischemic Strokes and Transient Ischemic Attacks Using Echocardiographic Measurements of Left Atrium Function

    DEFF Research Database (Denmark)

    Skaarup, Kristoffer Grundtvig; Christensen, Hanne; Høst, Nis;

    2016-01-01

    AF in patients with ischemic stroke (IS) and transient ischemic attack (TIA). We retrospectively analyzed 219 patients who after acute IS or TIA underwent a transthoracic echocardiographic examination. Patients were designated as patients with paroxysmal AF if they had one or more reported incidents...

  17. Circumstances Surrounding Male Sexual Assault and Rape: Findings from the National Violence against Women Survey

    Science.gov (United States)

    Light, David; Monk-Turner, Elizabeth

    2009-01-01

    Much work in the area of male sexual assault and rape relies on small clinical samples. From these samples, researchers reported that most male victims were physically injured during the attack and that penetration occurred. This work rests on a subsample of 219 men from the 1994-1996 Violence and Threats of Violence Against Women and Men in the…

  18. The Genetic and Environmental Covariation among Psychopathic Personality Traits, and Reactive and Proactive Aggression in Childhood

    Science.gov (United States)

    Bezdjian, Serena; Tuvblad, Catherine; Raine, Adrian; Baker, Laura A.

    2011-01-01

    The present study investigated the genetic and environmental covariance between psychopathic personality traits with reactive and proactive aggression in 9- to 10-year-old twins (N = 1,219). Psychopathic personality traits were assessed with the Child Psychopathy Scale (D. R. Lynam, 1997), while aggressive behaviors were assessed using the…

  19. Towards effective interventions for transgender people and their clients to prevent HIV infection and transmission : A study of the psychological determinants, sexual behavior s, and socio-demographic characteristics related to condom use and health care use

    NARCIS (Netherlands)

    Prabawanti, Ciptasari

    2015-01-01

    In Indonesia, transgender people (waria) have the second highest HIV prevalence (21.9%), the first being people who inject drugs (36.4%). To reduce HIV incidence among transgender people and prevent HIV transmission, they should have access to all prevention services including education, prevention

  20. Palmyra Atoll Site 15P 3/31/2004 98-99M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Palmyra Atoll, site 15P (05 52.219N, 162 02.697W), between 98 and 99 meters along a permanent transect.