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Sample records for astatine 216

  1. Bibliography of astatine chemistry and biomedical applications

    International Nuclear Information System (INIS)

    An overall bibliography is presented on astatine chemistry and on the biomedical applications of its 211At isotope. The references were grouped in the following chapters: General reviews; Discovery, Natural Occurence; Nuclear Data; Preparation, Handling, Radiation Risk; Physico-chemical Properties; Astatine Compounds and Chemical Reactions; Biological Effects and Applications. Entries are sorted alphabetically by authors name in each chapter, and cross-references to other chapters are provided if appropriate. (R.P.)

  2. Astatine-211: production and availability.

    Science.gov (United States)

    Zalutsky, Michael R; Pruszynski, Marek

    2011-07-01

    The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211 can be produced in reasonable yield from natural bismuth targets via the (209)Bi(α,2n)(211)At nuclear reaction utilizing straightforward methods. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of (210)At, which is problematic because of its 138.4-day half life α-particle emitting daughter, (210)Po. The intrinsic cost for producing (211)At is reasonably modest and comparable to that of commercially available (123)I. The major impediment to (211)At availability is attributed to the need for a medium energy α-particle beam for its production. On the other hand, there are about 30 cyclotrons in the world that have the beam characteristics required for (211)At production. PMID:22201707

  3. Adsorption interaction of astatine species with quartz and gold surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Serov, A. [Paul Scherrer Institute, Villigen (Switzerland). Lab. for Radiochemistry and Environmental Chemistry; Bern Univ. (Switzerland). Dept. for Chemistry and Biochemistry; Aksenov, N.; Bozhikov, G. [Joint Institute for Nuclear Research, Dubna (RU). Flerov Lab. of Nuclear Reactions] (and others)

    2011-07-01

    The adsorption interaction of various astatine species with quartz and gold surfaces was investigated by gas chromatography methods. Due to variations of the redox potential of the carrier gas elemental astatine, astatine oxide and hypo-astatic acid have been produced. The identification of the astatine compounds is based on the analogy assumption to the gas phase chemistry of the closest homologues in group 17 of the periodic table, iodine and bromine. The deposition temperatures as well as enthalpies of adsorption have been determined for the astatine species. The enhancement of the metallic character within group 17 towards higher Z is clearly confirmed. Macroscopic properties (sublimation enthalpy) of previously unstudied AtO{sub 2} and HAtO were estimated. The determined data for elemental astatine were compared to available literature data. Based on the obtained experimental results possible designs of experiments for studying of chemical properties of the recently discovered element 117 can be suggested. (orig.)

  4. Recent advances in the organic chemistry of astatine

    International Nuclear Information System (INIS)

    Investigation on the chemical behaviour of astatine in the last decade are surveyed. The survey covers the physical and chemical properties of astatine, synthesis and identification of organic astatine compounds, their physicochemical properties. A special chapter is devoted to biomedical applications, including inorganic 211At species, 211At-labelled proteins and drugs. An extensive bibliography of the related literature is given. (N.T.) 129 refs.; 12 figs.; 14 tabs

  5. Discovery of the astatine, radon, francium, and radium isotopes

    CERN Document Server

    Fry, C

    2012-01-01

    Currently, thirty-nine astatine, thirty-nine radon, thirty-five francium, and thirty-four radium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  6. Extraction of astatine isotopes for development of radiopharmaceuticals using a 211Rn-211At generator

    International Nuclear Information System (INIS)

    In order to utilize a 211At isotope, a promising α-emitter for radionuclide therapy, the chemical properties of astatine isotopes are studied. We have examined wet chemistry methods through the distribution ratios of astatine in liquid-liquid extraction. The astatine isotopes have been found to be well extracted into DIPE and MIBK. We observed that the distribution ratio of astatine isotopes increases with concentrations of HCl greater than 3 M, while it decreases with the HCl concentration less than 2 M. The results will be useful for development of the 211Rn-211At generator. (author)

  7. XMGT 216 courses/snaptutorial

    OpenAIRE

    Paul Marlowe

    2015-01-01

    For more classes visit www.snaptutorial.com   XMGT 216 Week 1 CheckPoint Ethical Theories Chart XMGT 216 Week 1 Discussion Question 1 & 2 XMGT 216 Week 2 CheckPoint Clarifying Personal Values XMGT 216 Week 2 Assignment Business Ethics Reflection XMGT 216 Week 3 CheckPoint Ethics Awareness Inventory XMGT 216 Week 3 Discussion Question 1 & 2 XMGT 216 Week 4 Assignment Ethical Issues and Management Paper XMGT 216 Week 4 CheckPoint Short Case M...

  8. Astatine-211-Labeled Targeted Radiotherapeutics: An Update

    International Nuclear Information System (INIS)

    The heavy halogen 211At was first proposed for use in α-particle targeted radiotherapy more than 30 years ago and continues to be one of the most promising radionuclides for this purpose. Although its 7.2-h half life is not ideal for intravenously administered whole antibodies, it is compatible with the pharmacokinetics of antibody fragments, peptides, aptamers and organic molecules. Its diverse chemistry allows its incorporation into a wide array of targeting vehicles, relying on its chemical similarity to iodine to provide a useful point of departure. On the other hand, the relatively low carbon-astatine bond strength is challenging. In common with the other α-emitters being discussed at this symposium, lack of reliable availability is one of the biggest hurdles in the use of 211At for targeted radiotherapy. However, in the case of 211At, it is not a question of production cost or availability of target material, because 211At can be produced in reasonable yield from natural bismuth targets. Rather, the difficulty is the lack of cyclotrons equipped with the medium energy α-particle beams required for its production. If the infrastructure for producing 211At is to be improved to the stage where 211At-labeled radiopharmaceuticals can have a meaningful impact, several developments must occur. First, the ability to produce clinically relevant levels of 211At that can be shipped to remote locations in chemically tractable form must be demonstrated. Approaches under consideration include compensating for radiolysis-mediated effects and the consideration of alternative chemistries. Second, strategies for compensating for heterogeneities in dose deposition must be developed, hopefully in a way that is compatible with approval for human use. And third, it is essential that more clinical trials be performed with 211At-labeled therapeutics, particularly in settings of minimum residual disease where the radiobiological advantages of α-particles can be best exploited. Our

  9. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    CERN Document Server

    Rothe, S; Antalic, S; Borschevsky, A; Capponi, L; Cocolios, T E; De Witte, H; Eliav, E; Fedorov, D V; Fedosseev, V N; Fink, D A; Fritzsche, S; Ghys, L; Huyse, M; Imai, N; Kaldor, U; Kudryavtsev, Yu; Köster, U; Lane, J; Lassen, J; Liberati, V; Lynch, K M; Marsh, B A; Nishio, K; Pauwels, D; Pershina, V; Popescu, L; Procter, T J; Radulov, D; Raeder, S; Rajabali, M M; Rapisarda, E; Rossel, R E; Sandhu, K; Seliverstov, M D; Sjödin, A M; Van den Bergh, P; Van Duppen, P; Venhart, M; Wakabayashi, Y; Wendt K D A

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of smallest quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.317510(8) eV. New ab initio calculations were performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of super-heavy element 117, the heaviest homologue of astatine.

  10. XMGT 216 Courses Tutorial / indigohelp

    OpenAIRE

    XMISSION

    2015-01-01

    XMGT 216 Week 1 CheckPoint Ethical Theories Chart XMGT 216 Week 1 Discussion Question 1 & 2 XMGT 216 Week 2 CheckPoint Clarifying Personal Values XMGT 216 Week 2 Assignment Business Ethics Reflection XMGT 216 Week 3 CheckPoint Ethics Awareness Inventory XMGT 216 Week 3 Discussion Question 1 & 2 XMGT 216 Week 4 Assignment Ethical Issues and Management Paper XMGT 216 Week 4 CheckPoint Short Case Management XMGT 216 Week 5 CheckPoint Management Case Study ...

  11. Synthesis and Evaluation of Astatinated N-[2-(Maleimido)ethyl]-3-(trimethylstannyl)benzamide Immunoconjugates.

    Science.gov (United States)

    Aneheim, Emma; Gustafsson, Anna; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Svedhem, Sofia; Lindegren, Sture

    2016-03-16

    Effective treatment of metastasis is a great challenge in the treatment of different types of cancers. Targeted alpha therapy utilizes the short tissue range (50-100 μm) of α particles, making the method suitable for treatment of disseminated occult cancers in the form of microtumors or even single cancer cells. A promising radioactive nuclide for this type of therapy is astatine-211. Astatine-211 attached to tumor-specific antibodies as carrier molecules is a system currently under investigation for use in targeted alpha therapy. In the common radiolabeling procedure, astatine is coupled to the antibody arbitrarily on lysine residues. By instead coupling astatine to disulfide bridges in the antibody structure, the immunoreactivity of the antibody conjugates could possibly be increased. Here, the disulfide-based conjugation was performed using a new coupling reagent, maleimidoethyl 3-(trimethylstannyl)benzamide (MSB), and evaluated for chemical stability in vitro. The immunoconjugates were subsequently astatinated, resulting in both high radiochemical yield and high specific activity. The MSB-conjugate was shown to be stable with a long shelf life prior to the astatination. In a comparison of the in vivo distribution of the new immunoconjugate with other tin-based immunoconjugates in tumor-bearing mice, the MSB conjugation method was found to be a viable option for successful astatine labeling of different monoclonal antibodies. PMID:26791409

  12. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    OpenAIRE

    Rothe, S.; A. N. Andreyev; Antalic, S; Borschevsky, A.; Capponi, L.; Cocolios, T.E.; Witte, H.; Eliav, E.; Fedorov, D. V.; Fedosseev, V. N.; Fink, D. A.; Fritzsche, S.; Ghys, L.; Huyse, M.; Imai, N.

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the io...

  13. XMGT 216 UOP Tutorial/Uoptutorial

    OpenAIRE

    David Lawrence

    2015-01-01

    For more course tutorials visit www.uoptutorial.com     XMGT 216 week 1 CheckPoint Ethical Theories Chart XMGT 216 week 1 Discussion Question 1 & 2 XMGT 216 week 2 CheckPoint Clarifying Personal Values XMGT 216 week 2 Assignment Business Ethics Reflection XMGT 216 week 3 CheckPoint Ethics Awareness Inventory XMGT 216 week 3 Discussion Question 1 & 2 XMGT 216 week 4 Assignment Ethical Issues and Management Paper XMGT 216 week 4 Chec...

  14. XMGT 216 Course tutorial/uophelp

    OpenAIRE

    SXZX

    2015-01-01

    XMGT 216 Entire Course For more course tutorials visit www.uophelp.com     XMGT 216 Week 1 CheckPoint Ethical Theories Chart XMGT 216 Week 1 Discussion Question 1 & 2 XMGT 216 Week 2 CheckPoint Clarifying Personal Values XMGT 216 Week 2 Assignment Business Ethics Reflection XMGT 216 Week 3 CheckPoint Ethics Awareness Inventory XMGT 216 Week 3 Discussion Question 1 & 2 XMGT 216 Week 4 Assignment Ethical Issues and Management Paper ...

  15. XMGT 216 UOP Tutorial Course/Uoptutorial

    OpenAIRE

    anemone221

    2015-01-01

    For More Course Tutorials Visit www.uoptutorial.com     XMGT 216 week 1 CheckPoint Ethical Theories Chart XMGT 216 week 1 Discussion Question 1 & 2 XMGT 216 week 2 CheckPoint Clarifying Personal Values XMGT 216 week 2 Assignment Business Ethics Reflection XMGT 216 week 3 CheckPoint Ethics Awareness Inventory XMGT 216 week 3 Discussion Question 1 & 2 XMGT 216 week 4 Assignment Ethical Issues and Management Paper XMGT 216 week 4 Chec...

  16. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    DEFF Research Database (Denmark)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom;

    2015-01-01

    To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical...... and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitted α-particles, this therapy is particularly suited to treating occult, disseminated cancers. Astatine is not intrinsically tumour-specific; therefore, it requires an appropriate tumour-specific targeting...... vector, which can guide the radiation to the cancer cells. Consequently, an appropriate method is required for coupling the nuclide to the vector. To increase the availability of astatine-211 radiopharmaceuticals for targeted alpha therapy, their production should be automated. Here, we present a method...

  17. Study of Astatine (III) reactions with O, S and N ligands in solution

    International Nuclear Information System (INIS)

    Full text of publication follows. Astatine (At, Z=85: [Xe]4f145d106s26p5) belongs to the halogen group and is located below iodine in the periodic table. One of its isotopes (211At) appears promising as a therapeutic agent in nuclear medicine (Ref.1) owing to the energy of the alpha particles emitted during the disintegration of its nucleus and its short physical half-life (7.2 h). Since there are no stable isotopes of astatine, the chemistry of this element remains poorly understood. Generally, At is supposed to behave as a halogen (Ref.2) but it has been shown recently in our group that astatine presents a metallic behaviour in aqueous solution: it notably exists as At+ and AtO+ species under the oxidation states +I and +III (Ref.3). At the present time, the number of studies dealing with the complexation properties of the cationic forms of astatine remains limited (Ref.4), owing to its low availability. In this work, we have investigated the reactions of AtO+ species with different hetero-atomic (N, S, O) model ligands. A combined approach based on experimental and theoretical studies has been used (Ref.5). On account of the difficulties of experimental investigations of astatine species, the reactivity of AtO+ was explored using a competition method founded on astatine distributions between two distinct phases. Furthermore, for each AtO+/ ligand complex, the nature of the species formed and the associated thermodynamic constants were determined by computational modeling (DFT calculations). In this framework, an original computational methodology was developed to take into account the specificities of astatine, notably the associated relativistic effects. The computed equilibrium constants have been confronted with the experimental results. This comparison demonstrates an outstanding coherence between experience and theory. Furthermore, the analysis of the results shows a key role of solvent effects on astatine chemistry. Lastly, a specific reactivity for the

  18. Some aspects of the organic, biological and inorganic chemistry of astatine

    International Nuclear Information System (INIS)

    Astatine has no stable isotopes and the radioactive isotopes with half-lives sufficiently long for chemical experiments (209At, 210At, 211At) must be produced artificially with a cyclotron or with a high energy accelerator by spallation of Th. This thesis deals with the synthesis and chemistry of At-compounds and the determination of some of their properties. (C.F.)

  19. Astatine-211 Pathway from Radiochemistry to Clinical Investigation

    International Nuclear Information System (INIS)

    Particularly in clinical settings where tumour burden is low and cancers are located in close proximity to essential normal tissue structures, α-particle emitting radionuclides can offer significant advantages for targeted radionuclide therapy. One of the first alpha emitters to be evaluated for this purpose is the 7.2-h half-life radiohalogen Astatine-211 (211At). From a commercialization-potential perspective 211At, is less appealing than the longer half-life alpha particle emitters Radium-223, Actinium-225 and Thorium-227, which have become the focus of many laboratories. However, if methods for providing a better supply of 211At could be developed, this alpha emitter would be the radionuclide of choice for many potential therapeutic applications. With regard to the production of 211At, this can be readily be accomplished by bombarding natural bismuth targets with 28−29.5 MeV alpha particles via the 209Bi(α,2n)211At reaction. The goal is to utilize an alpha particle beam energy that provides the required balance for maximizing 211At production while minimizing creation of 210At, which is problematic because of its 138.4-day half life alpha-particle emitting daughter, 210Po. For most intended clinical applications, alpha particle beam energy of about 29 MeV offers the best compromise between maximizing yield and providing 211At with sufficient radionuclidic purity for clinical use. Clinically relevant levels of 211At have been produced at several institutions using both internal and external cyclotron targets

  20. An attempt to explore the production routes of Astatine radionuclides: Theoretical approach

    OpenAIRE

    Maiti, Moumita; Lahiri, Susanta

    2008-01-01

    In order to fulfil the recent thrust of Astatine radionuclides in the field of nuclear medicine various production routes have been explored in the present work. The possible production routes of $^{209-211}$At comprise both light and heavy ion induced reactions at the bombarding energy range starting from threshold to maximum 100 MeV energy. For this purpose, we have used the nuclear reaction model codes TALYS, ALICE91 and PACE-II. Excitation functions of those radionuclides, produced throug...

  1. 32 CFR 216.5 - Responsibilities.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 216.5 Section 216.5 National... § 216.5 Responsibilities. (a) The PDUSD(P&R), under the Under Secretary of Defense for Personnel and... appropriate preparations to carry out their responsibilities should a covered school be determined...

  2. 50 CFR 216.42 - Photography. [Reserved

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Photography. 216.42 Section 216.42 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION... Special Exceptions § 216.42 Photography....

  3. 12 CFR 741.216 - Flood insurance.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Flood insurance. 741.216 Section 741.216 Banks... INSURANCE Regulations Codified Elsewhere in NCUA's Regulations as Applying to Federal Credit Unions That Also Apply to Federally Insured State-Chartered Credit Unions § 741.216 Flood insurance. Any...

  4. 50 CFR 216.87 - Wildlife research.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Wildlife research. 216.87 Section 216.87... Pribilof Islands Administration § 216.87 Wildlife research. (a) Wildlife research, other than research on... to the following conditions: (1) Any person or agency, seeking to conduct such research shall...

  5. 22 CFR 216.8 - Public hearings.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Public hearings. 216.8 Section 216.8 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ENVIRONMENTAL PROCEDURES § 216.8 Public hearings. (a) In most instances AID will be able to gain the benefit of public participation in the impact statement...

  6. 50 CFR 216.82 - Dogs prohibited.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Dogs prohibited. 216.82 Section 216.82... Pribilof Islands Administration § 216.82 Dogs prohibited. In order to prevent molestation of fur seal herds, the landing of any dogs at Pribilof Islands is prohibited....

  7. 29 CFR 500.216 - Substituted service.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Substituted service. 500.216 Section 500.216 Labor... Service § 500.216 Substituted service. (a) Pursuant to section 102(5) of the Act, the Secretary, when so designated by a court, shall accept service of summons in any action arising under the Act or...

  8. Determination of the electron affinity of astatine and polonium by laser photodetachment

    CERN Multimedia

    We propose to conduct the first electron anity (EA) measurements of the two elements astatine (At) and polonium (Po). Collinear photodetachment spectroscopy will allow us to measure these quantities with an uncertainty limited only by the spectral linewidth of the laser. We plan to use negative ion beams of the two radioactive elements At and Po, which are only accessible on-line and at ISOLDE. The feasibility of our proposed method and the functionality of the experimental setup have been demonstrated at ISOLDE in o-line tests by the clear observation of the photodetachment threshold for stable iodine. This proposal is based on our Letter of Intent I-148 [1].

  9. 31 CFR 0.216 - Privacy Act.

    Science.gov (United States)

    2010-07-01

    ... 1974, as amended (5 U.S.C. 552a), shall comply with the conduct regulations delineated in 31 CFR 1.28(b). ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Privacy Act. 0.216 Section 0.216... RULES OF CONDUCT Rules of Conduct § 0.216 Privacy Act. Employees involved in the design,...

  10. Dicty_cDB: CFD216 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CF (Link to library) CFD216 (Link to dictyBase) - - - Contig-U16368-1 CFD216P (Link to Original site) CFD...216F 604 CFD216Z 406 CFD216P 1010 - - Show CFD216 Library CF (Link to library) Clone ID CFD...e URL http://dictycdb.biol.tsukuba.ac.jp/CSM/CF/CFD2-A/CFD216Q.Seq.d/ Representative seq. ID CFD...216P (Link to Original site) Representative DNA sequence >CFD216 (CFD216Q) /CSM/CF/CFD2-A/CFD...Score E Sequences producing significant alignments: (bits) Value CFD216 (CFD216Q) /CSM/CF/CFD2-A/CFD216Q.Seq

  11. 22 CFR 216.3 - Procedures.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Procedures. 216.3 Section 216.3 Foreign..., before a final decision is made to provide A.I.D. funding for the action. (2) Threshold decision. (i) The... procurement or use, or both, of pesticides for research or limited field evaluation purposes by or under...

  12. 32 CFR 216.6 - Information requirements.

    Science.gov (United States)

    2010-07-01

    ... EDUCATION § 216.6 Information requirements. The information requirements identified at § 216.5(b) and (c)(1..., ABC University, Anywhere, USA 12345-9876. Dear Dr. Doe: I understand that military recruiting... listing, age (or year of birth), level of education (e.g., freshman, sophomore, or degree awarded for...

  13. 36 CFR 216.5 - Documentation.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Documentation. 216.5 Section... PUBLIC IN THE FORMULATION OF FOREST SERVICE DIRECTIVES § 216.5 Documentation. The responsible Forest... reasons therefor, in a concise written summary. The summary may be combined with documentation required...

  14. 31 CFR 800.216 - Foreign person.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Foreign person. 800.216 Section 800... TAKEOVERS BY FOREIGN PERSONS Definitions § 800.216 Foreign person. The term foreign person means: (a) Any foreign national, foreign government, or foreign entity; or (b) Any entity over which control is...

  15. 18 CFR 157.216 - Abandonment.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Abandonment. 157.216 Section 157.216 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT... firm contract; or (2) A facility that did or could now qualify for automatic authorization as...

  16. 48 CFR 216.405 - Cost-reimbursement incentive contracts.

    Science.gov (United States)

    2010-10-01

    ... incentive contracts. 216.405 Section 216.405 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 216.405 Cost-reimbursement incentive contracts....

  17. 29 CFR 1603.216 - Summary decision.

    Science.gov (United States)

    2010-07-01

    ... EXEMPT STATE AND LOCAL GOVERNMENT EMPLOYEE COMPLAINTS OF EMPLOYMENT DISCRIMINATION UNDER SECTION 304 OF THE GOVERNMENT EMPLOYEE RIGHTS ACT OF 1991 Hearings § 1603.216 Summary decision. Upon motion of...

  18. Dicty_cDB: SSI216 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSI216 (Link to dictyBase) - - - Contig-U16483-1 SSI216Z (Link to Original si...ycdb.biol.tsukuba.ac.jp/CSM/SS/SSI2-A/SSI216Q.Seq.d/ Representative seq. ID SSI216Z (Link to Original si...te) - - SSI216Z 644 - - - - Show SSI216 Library SS (Link to library) Clone ID SSI216 (Link to... dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U16483-1 Original site URL http://dict...te) Representative DNA sequence >SSI216 (SSI216Q) /CSM/SS/SSI2-A/SSI216Q.Seq.d/ XXXXX

  19. Unexpected Behavior of the Heaviest Halogen Astatine in the Nucleophilic Substitution of Aryliodonium Salts.

    Science.gov (United States)

    Guérard, François; Lee, Yong-Sok; Baidoo, Kwamena; Gestin, Jean-François; Brechbiel, Martin W

    2016-08-22

    Aryliodonium salts have become precursors of choice for the synthesis of (18) F-labeled tracers for nuclear imaging. However, little is known on the reactivity of these compounds with heavy halides, that is, radioiodide and astatide, at the radiotracer scale. In the first comparative study of radiohalogenation of aryliodonium salts with (125) I(-) and (211) At(-) , initial experiments on a model compound highlight the higher reactivity of astatide compared to iodide, which could not be anticipated from the trends previously observed within the halogen series. Kinetic studies indicate a significant difference in activation energy (Ea =23.5 and 17.1 kcal mol(-1) with (125) I(-) and (211) At(-) , respectively). Quantum chemical calculations suggest that astatination occurs via the monomeric form of an iodonium complex whereas iodination occurs via a heterodimeric iodonium intermediate. The good to excellent regioselectivity of halogenation and high yields achieved with diversely substituted aryliodonium salts indicate that this class of compounds is a promising alternative to the stannane chemistry currently used for heavy radiohalogen labeling of tracers in nuclear medicine. PMID:27305065

  20. Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

    CERN Document Server

    Andreyev, Andrei

    2013-01-01

    Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

  1. 27 CFR 28.216 - Export marks.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.216... Export marks. In addition to the marks and brands required to be placed on packages or other bulk... “Export” on the Government side of each case or Government head of each container before removal...

  2. 20 CFR 498.216 - Witnesses.

    Science.gov (United States)

    2010-04-01

    ... § 498.216 Witnesses. (a) Except as provided in paragraph (b) of this section, testimony at the hearing..., testimony (other than expert testimony) may be admitted in the form of a written statement. Any such written statement must be provided to all other parties along with the last known address of such witness, in...

  3. 22 CFR 216.1 - Introduction.

    Science.gov (United States)

    2010-04-01

    ... Statement is further described in § 216.7 infra. (6) Project Identification Document (PID). An internal A.I... environment. (12) Minor donor. For purposes of these procedures, A.I.D. is a minor donor to a multidonor... of the estimated project cost and the environmental procedures of the donor in control of...

  4. 32 CFR 552.216 - Violations.

    Science.gov (United States)

    2010-07-01

    ... on the Installation of Aberdeen Proving Ground, Maryland § 552.216 Violations. (a) A person is in violation of the terms of this subpart if: (1) That person enters or remains upon Aberdeen Proving Ground..., Aberdeen Proving Ground pursuant to the terms of § 552.214; or (2) That person enters upon or remains...

  5. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

    Energy Technology Data Exchange (ETDEWEB)

    MICHAEL R. ZALUTSKY

    2012-08-08

    Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

  6. 25 CFR 216.7 - Approval of mining plan.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Approval of mining plan. 216.7 Section 216.7 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS SURFACE EXPLORATION, MINING, AND RECLAMATION OF LANDS General Provisions § 216.7 Approval of mining plan. (a) Before surface mining...

  7. 9 CFR 113.216 - Bovine Rhinotracheitis Vaccine, Killed Virus.

    Science.gov (United States)

    2010-01-01

    ... Virus. 113.216 Section 113.216 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.216 Bovine Rhinotracheitis Vaccine, Killed Virus. Infectious...

  8. 40 CFR 86.216-94 - Calibrations, frequency and overview.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Calibrations, frequency and overview. 86.216-94 Section 86.216-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... New Medium-Duty Passenger Vehicles; Cold Temperature Test Procedures § 86.216-94...

  9. 40 CFR 2.216-2.300 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false 2.216-2.300 Section 2.216-2.300 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PUBLIC INFORMATION Confidentiality of Business Information §§ 2.216-2.300...

  10. 29 CFR 2.16 - Conduct of hearings.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Conduct of hearings. 2.16 Section 2.16 Labor Office of the Secretary of Labor GENERAL REGULATIONS Audiovisual Coverage of Administrative Hearings § 2.16 Conduct of... setting up or using equipment needed for its audiovisual coverage....

  11. 42 CFR 57.216a - Performance standard.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Performance standard. 57.216a Section 57.216a... Professions Student Loans § 57.216a Performance standard. On June 30, 1984, and on each June 30 thereafter, except as provided in paragraph (b) of this section, each school must have a default rate (as...

  12. 49 CFR 216.27 - Reservation of authority and discretion.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Reservation of authority and discretion. 216.27 Section 216.27 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD..., LOCOMOTIVE AND EQUIPMENT Emergency Order-Track § 216.27 Reservation of authority and discretion. The FRA...

  13. 216-B-3 expansion ponds closure plan

    Energy Technology Data Exchange (ETDEWEB)

    1994-10-01

    This document describes the activities for clean closure under the Resource Conservation and Recovery Act of 1976 (RCRA) of the 216-B-3 Expansion Ponds. The 216-B-3 Expansion Ponds are operated by the US Department of Energy, Richland Operations Office (DOE-RL) and co-operated by Westinghouse Hanford Company (Westinghouse Hanford). The 216-B-3 Expansion Ponds consists of a series of three earthen, unlined, interconnected ponds that receive waste water from various 200 East Area operating facilities. The 3A, 3B, and 3C ponds are referred to as Expansion Ponds because they expanded the capability of the B Pond System. Waste water (primarily cooling water, steam condensate, and sanitary water) from various 200 East Area facilities is discharged to the Bypass pipe (Project X-009). Water discharged to the Bypass pipe flows directly into the 216-B-3C Pond. The ponds were operated in a cascade mode, where the Main Pond overflowed into the 3A Pond and the 3A Pond overflowed into the 3C Pond. The 3B Pond has not received waste water since May 1985; however, when in operation, the 3B Pond received overflow from the 3A Pond. In the past, waste water discharges to the Expansion Ponds had the potential to have contained mixed waste (radioactive waste and dangerous waste). The radioactive portion of mixed waste has been interpreted by the US Department of Energy (DOE) to be regulated under the Atomic Energy Act of 1954; the dangerous waste portion of mixed waste is regulated under RCRA.

  14. 216-B-3 expansion ponds closure plan

    International Nuclear Information System (INIS)

    This document describes the activities for clean closure under the Resource Conservation and Recovery Act of 1976 (RCRA) of the 216-B-3 Expansion Ponds. The 216-B-3 Expansion Ponds are operated by the US Department of Energy, Richland Operations Office (DOE-RL) and co-operated by Westinghouse Hanford Company (Westinghouse Hanford). The 216-B-3 Expansion Ponds consists of a series of three earthen, unlined, interconnected ponds that receive waste water from various 200 East Area operating facilities. The 3A, 3B, and 3C ponds are referred to as Expansion Ponds because they expanded the capability of the B Pond System. Waste water (primarily cooling water, steam condensate, and sanitary water) from various 200 East Area facilities is discharged to the Bypass pipe (Project X-009). Water discharged to the Bypass pipe flows directly into the 216-B-3C Pond. The ponds were operated in a cascade mode, where the Main Pond overflowed into the 3A Pond and the 3A Pond overflowed into the 3C Pond. The 3B Pond has not received waste water since May 1985; however, when in operation, the 3B Pond received overflow from the 3A Pond. In the past, waste water discharges to the Expansion Ponds had the potential to have contained mixed waste (radioactive waste and dangerous waste). The radioactive portion of mixed waste has been interpreted by the US Department of Energy (DOE) to be regulated under the Atomic Energy Act of 1954; the dangerous waste portion of mixed waste is regulated under RCRA

  15. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    Energy Technology Data Exchange (ETDEWEB)

    Rothe, Sebastian

    2012-09-24

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  16. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    International Nuclear Information System (INIS)

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  17. 50 CFR 216.256 - Applications for Letters of Authorization.

    Science.gov (United States)

    2010-10-01

    ... ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND... in the Gulf of Mexico § 216.256 Applications for Letters of Authorization. To incidentally...

  18. Radiobiological Effects of Alpha-Particles from Astatine-211: From DNA Damage to Cell Death

    Energy Technology Data Exchange (ETDEWEB)

    Claesson, Kristina

    2011-05-15

    In recent years, the use of high linear energy transfer (LET) radiation for radiotherapeutic applications has gained increased interest. Astatine-211 (211At) is an alpha-particle emitting radionuclide, promising for targeted radioimmunotherapy of isolated tumor cells and microscopic clusters. To improve development of safe radiotherapy using 211At it is important to increase our knowledge of the radiobiological effects in cells. During radiotherapy, both tumors and adjacent normal tissue will be irradiated and therefore, it is of importance to understand differences in the radio response between proliferating and resting cells. The aim of this thesis was to investigate effects in fibroblasts with different proliferation status after irradiation with alpha-particles from 211At or X-rays, from inflicted DNA damage, to cellular responses and biological consequences. Throughout this work, irradiation was performed with alpha-particles from 211A or X-rays. The induction and repair of double-strand breaks (DSBs) in human normal fibroblasts were investigated using pulsed-field gel electrophoresis and fragment analysis. The relative biological effectiveness (RBE) of 211At for DSB induction varied between 1.4 and 3.1. A small increase of DSBs was observed in cycling cells compared to stationary cells. The repair kinetics was slower after 211At and more residual damage was found after 24 h. Comparison between cells with different proliferation status showed that the repair was inefficient in cycling cells with more residual damage, regardless of radiation quality. Activation of cell cycle arrests was investigated using immunofluorescent labeling of the checkpoint kinase Chk2 and by measuring cell cycle distributions with flow cytometry analysis. After alpha-particle irradiation, the average number of Chk2-foci was larger and the cells had a more affected cell cycle progression for several weeks compared with X-irradiated cells, indicating a more powerful arrest after 211At

  19. 27 CFR 40.216a - Notice for pipe tobacco.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Notice for pipe tobacco. 40.216a Section 40.216a Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) TOBACCO MANUFACTURE OF TOBACCO PRODUCTS, CIGARETTE...

  20. 34 CFR 682.216 - Teacher loan forgiveness program.

    Science.gov (United States)

    2010-07-01

    ... teacher is permitted to and does satisfy rigorous subject knowledge and skills tests by taking competency... 34 Education 3 2010-07-01 2010-07-01 false Teacher loan forgiveness program. 682.216 Section 682... § 682.216 Teacher loan forgiveness program. (a) General. (1) The teacher loan forgiveness program...

  1. 50 CFR 216.91 - Dolphin-safe labeling standards.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Dolphin-safe labeling standards. 216.91... MAMMALS Dolphin Safe Tuna Labeling § 216.91 Dolphin-safe labeling standards. (a) It is a violation of... include on the label of those products the term “dolphin-safe” or any other term or symbol that claims...

  2. 50 CFR 216.71 - Allowable take of fur seals.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Allowable take of fur seals. 216.71... MAMMALS Pribilof Islands, Taking for Subsistence Purposes § 216.71 Allowable take of fur seals. Pribilovians may take fur seals on the Pribilof Islands if such taking is (a) For subsistence uses, and (b)...

  3. 50 CFR 216.83 - Importation of birds or mammals.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Importation of birds or mammals. 216.83... ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS Pribilof Islands Administration § 216.83 Importation of birds or mammals. No mammals or...

  4. 48 CFR 52.216-10 - Incentive Fee.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Incentive Fee. 52.216-10 Section 52.216-10 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED...) Inconsistencies. In the event of any language inconsistencies between this clause and provisioning documents...

  5. 28 CFR 2.216 - Revocation hearing procedure.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Revocation hearing procedure. 2.216 Section 2.216 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND RECOMMITMENT... identity of a confidential informant or result in harm to any person, that information may be withheld...

  6. 47 CFR 36.216 - Uncollectible revenue-Account 5300.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Uncollectible revenue-Account 5300. 36.216..., REVENUES, EXPENSES, TAXES AND RESERVES FOR TELECOMMUNICATIONS COMPANIES 1 Operating Revenues and Certain Income Accounts Operating Revenues § 36.216 Uncollectible revenue—Account 5300. The amounts in...

  7. 48 CFR 52.216-6 - Price Redetermination-Retroactive.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Price Redetermination-Retroactive. 52.216-6 Section 52.216-6 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... of the excess has been applied to the liquidation of progress payments, then that portion...

  8. 48 CFR 1852.216-81 - Estimated cost.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Estimated cost. 1852.216-81... Estimated cost. As prescribed in 1816.307-70(d), insert the following clause: Estimated cost (DEC 1988) The total estimated cost for complete performance of this contract is $ . See FAR clause 52.216-11,...

  9. 20 CFR 802.216 - Service and form of papers.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Service and form of papers. 802.216 Section... Prereview Procedures Initial Processing § 802.216 Service and form of papers. (a) All papers filed with the...), date of signature, and certificate of service. (b) For each paper filed with the Board, the...

  10. 36 CFR 2.16 - Horses and pack animals.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Horses and pack animals. 2.16... RESOURCE PROTECTION, PUBLIC USE AND RECREATION § 2.16 Horses and pack animals. The following are prohibited: (a) The use of animals other than those designated as “pack animals” for purposes of...

  11. 50 CFR 216.4 - Other laws and regulations.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Other laws and regulations. 216.4 Section... ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS Introduction § 216.4 Other laws and regulations. (a) Federal. Nothing in this part, nor any...

  12. 46 CFR 153.216 - Shower and eyewash fountains.

    Science.gov (United States)

    2010-10-01

    ... Vessel Requirements § 153.216 Shower and eyewash fountains. (a) Each non-self-propelled ship must have a fixed or portable shower and eyewash fountain that operates during cargo transfer and meets paragraph (c... 46 Shipping 5 2010-10-01 2010-10-01 false Shower and eyewash fountains. 153.216 Section...

  13. 12 CFR 216.1 - Purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... CONSUMER FINANCIAL INFORMATION (REGULATION P) § 216.1 Purpose and scope. (a) Purpose. This part governs the... who obtain financial products or services primarily for personal, family, or household purposes...

  14. Soil/sediment characterization for 216-A-29 ditch

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, R.M.

    1997-03-01

    This document provides a detailed description of the environmental samples collected from the 216-A-29 Ditch in 1988. Tables summarizing the laboratory data for radionuclides, metals, and soil chemistry are included.

  15. 50 CFR 216.259 - Modifications to Letters of Authorization.

    Science.gov (United States)

    2010-10-01

    ... ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND... in the Gulf of Mexico § 216.259 Modifications to Letters of Authorization. (a) Except as provided...

  16. 50 CFR 216.252 - Permissible methods of taking.

    Science.gov (United States)

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE... Mexico § 216.252 Permissible methods of taking. (a) Under Letters of Authorization issued pursuant...

  17. 50 CFR 216.257 - Letters of Authorization.

    Science.gov (United States)

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE... Mexico § 216.257 Letters of Authorization. (a) A Letter of Authorization, unless suspended or...

  18. 48 CFR 252.216-7001 - Economic price adjustment-nonstandard steel items.

    Science.gov (United States)

    2010-10-01

    ...-nonstandard steel items. 252.216-7001 Section 252.216-7001 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.216-7001 Economic price adjustment—nonstandard steel items. As prescribed in 216.203-4-70(b), use the following clause: Economic Price Adjustment—Nonstandard Steel...

  19. Results of 1998 spectral gamma-ray monitoring of boreholes at the 216-Z-1A tile field, 216-Z-9 trench, and 216-Z-12 crib

    International Nuclear Information System (INIS)

    This document describes the results of fiscal year 1998 vadose zone monitoring of three inactive liquid waste disposal facilities associated with the Plutonium Finishing Plant: the 216-Z-1A tile field, the 216-Z-9 trench, and the 216-Z-12 crib. Monitoring consisted of spectral gamma-ray logging of 21 boreholes. This work was performed by Pacific Northwest National Laboratory in conjunction with Three Rivers Scientific and Waste management Federal Services, inc. Northwest Operations. These three liquid waste disposal facilities were chosen for monitoring because they were identified as containing some of the most significant sources of radioactive contamination in the Hanford Site vadose zone. The basic question addressed by this logging activity is ''Has the configuration of subsurface contamination changed since it was last measured?'' Previous borehole logging and laboratory analyses provide the baseline data to help answer this question

  20. 216-U-10 Pond and 216-Z-19 Ditch characterization studies

    Energy Technology Data Exchange (ETDEWEB)

    Last, G.V.; Duncan, D.W.; Graham, M.J.; Hall, M.D.; Hall, V.W.; Landeen, D.S.; Leitz, J.G.; Mitchell, R.M.

    1994-02-01

    The chemical, reprocessing of spent nuclear fuels at the US Department of Energy`s Hanford Site has generated large volumes of radioactive liquid effluents. The majority of these effluents have been used strictly for cooling or other supportive functions and have been discharged to ditches and ponds. The 216-U-10 Pond and 216-Z-19 Ditch are two such disposal facilities. These facilities are components of an integrated system of ditches, ponds, and overflow facilities collectively referred to as the U-Pond disposal system. The U-Pond system has been used since 1943 and has received a large variety of radioisotopes from several sources. This study covered tho major aspects of the environment, including wind resuspension, biological uptake and transport, geologic distribution in surface and subsurface sediments, and ground-water impacts. The long-term use of U-Pond and the Z-19 Ditch has resulted in the localized accumulation of transuranic and fission product inventories as a result of sorption and filtration of particulates onto the uppermost sediments.

  1. 216-U-10 Pond and 216-Z-19 Ditch characterization studies

    International Nuclear Information System (INIS)

    The chemical, reprocessing of spent nuclear fuels at the US Department of Energy's Hanford Site has generated large volumes of radioactive liquid effluents. The majority of these effluents have been used strictly for cooling or other supportive functions and have been discharged to ditches and ponds. The 216-U-10 Pond and 216-Z-19 Ditch are two such disposal facilities. These facilities are components of an integrated system of ditches, ponds, and overflow facilities collectively referred to as the U-Pond disposal system. The U-Pond system has been used since 1943 and has received a large variety of radioisotopes from several sources. This study covered tho major aspects of the environment, including wind resuspension, biological uptake and transport, geologic distribution in surface and subsurface sediments, and ground-water impacts. The long-term use of U-Pond and the Z-19 Ditch has resulted in the localized accumulation of transuranic and fission product inventories as a result of sorption and filtration of particulates onto the uppermost sediments

  2. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D., Scott

    2011-12-14

    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  3. Combination RCRA groundwater monitoring plan for the 216-A-10, 216-A-36B, and 216-A-37-1 PUREX cribs

    Energy Technology Data Exchange (ETDEWEB)

    Lindberg, J.W.

    1997-06-01

    This document presents a groundwater quality assessment monitoring plan, under Resource Conservation and Recovery Act of 1976 (RCRA) regulatory requirements for three RCRA sites in the Hanford Site`s 200 East Area: 216-A-10, 216-A-36B, and 216-A-37-1 cribs (PUREX cribs). The objectives of this monitoring plan are to combine the three facilities into one groundwater quality assessment program and to assess the nature, extent, and rate of contaminant migration from these facilities. A groundwater quality assessment plan is proposed because at least one downgradient well in the existing monitoring well networks has concentrations of groundwater constituents indicating that the facilities have contributed to groundwater contamination. The proposed combined groundwater monitoring well network includes 11 existing near-field wells to monitor contamination in the aquifer in the immediate vicinity of the PUREX cribs. Because groundwater contamination from these cribs is known to have migrated as far away as the 300 Area (more than 25 km from the PUREX cribs), the plan proposes to use results of groundwater analyses from 57 additional wells monitored to meet environmental monitoring requirements of US Department of Energy Order 5400.1 to supplement the near-field data. Assessments of data collected from these wells will help with a future decision of whether additional wells are needed.

  4. Satraplatin: BMS 182751, BMY 45594, JM 216.

    Science.gov (United States)

    2007-01-01

    Satraplatin [BMS 182751, BMY 45594, JM 216] belongs to a series of orally-active platinum compounds with anticancer activity. It was jointly originated by Bristol-Myers Squibb, Johnson Matthey and the Institute of Cancer Research in the UK; however, Johnson Matthey has since ceased involvement with drug development. Subsequently, the agent has been licensed to and is under development with GPC Biotech, Pharmion and Spectrum Pharmaceuticals. Clinical trials are underway to evaluate satraplatin among patients with different tumour types, including prostate, breast, cervical and lung cancers. The compound is under regulatory review with the US FDA for the treatment of hormone-refractory prostate cancer. NeoTherapeutics (now Spectrum Pharmaceuticals) granted GPC Biotech an exclusive worldwide licence to develop and market satraplatin in October 2002. Under the terms of the agreement, GPC Biotech is fully funding development costs and commercialisation requirements for the drug. The deal also involves GPC Biotech paying a signing fee, milestone and royalty payments. Spectrum is a member of a joint development committee headed by GPC Biotech to govern development of satraplatin. Previously in October 2001, NeoOncoRx (Spectrum Pharmaceuticals) gained the rights to develop and market the compound worldwide. In December 2005, GPC Biotech and Pharmion Corporation entered into a co-development and license agreement for satraplatin. Under the agreement terms, Pharmion has exclusive commercialisation rights for Europe, Turkey, the Middle East, Australia and New Zealand, while GPC Biotech retains rights to North America and all other territories. Pharmion made an upfront payment of $US37.1 million to GPC Biotech, which included reimbursement for past clinical development costs plus funding for ongoing and certain clinical development activities to be jointly conducted by the companies. In addition, both parties will pursue a joint development plan for satraplatin in a variety of

  5. 75 FR 80885 - Fifteenth Meeting: EUROCAE WG-72: RTCA Special Committee 216: Aeronautical Systems Security...

    Science.gov (United States)

    2010-12-23

    ... PMC/ICC action on SC 216 TOR. Publication Progress and Update. Subgroup and Action Item Reports. Plenary review of EUROCAE Council and RTCA PMC actions on ED-202 and SC-216 TOR. Continuation of...

  6. 27 CFR 555.216 - Repair of magazines.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Repair of magazines. 555... EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Storage § 555.216 Repair of magazines. Before repairing the interior of magazines, all explosive materials are to be removed and the...

  7. 48 CFR 1252.216-72 - Performance evaluation plan.

    Science.gov (United States)

    2010-10-01

    ....216-72 Performance evaluation plan. As prescribed in (TAR) 48 CFR 1216.406(b), insert the following clause: Performance Evaluation Plan (OCT 1994) (a) A Performance Evaluation Plan shall be unilaterally... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Performance...

  8. 48 CFR 2452.216-73 - Performance evaluation plan.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Performance evaluation plan... 2452.216-73 Performance evaluation plan. As prescribed in 2416.406(e)(3), insert the following clause in all award fee contracts: Performance Evaluation Plan (AUG 1987) (a) The Government...

  9. 48 CFR 3052.216-72 - Performance evaluation plan.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Performance evaluation... CONTRACT CLAUSES Text of Provisions and Clauses 3052.216-72 Performance evaluation plan. As prescribed in (HSAR) 48 CFR 3016.406(e)(i)(ii), insert a clause substantially the same as the following:...

  10. 9 CFR 93.216 - Poultry from Canada.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Poultry from Canada. 93.216 Section 93... EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS IMPORTATION OF CERTAIN ANIMALS, BIRDS, FISH, AND POULTRY, AND CERTAIN ANIMAL, BIRD, AND POULTRY PRODUCTS; REQUIREMENTS FOR MEANS...

  11. 48 CFR 216.403 - Fixed-price incentive contracts.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Fixed-price incentive... SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 216.403 Fixed-price incentive contracts....

  12. 48 CFR 1852.216-83 - Fixed price incentive.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Fixed price incentive. 1852... 1852.216-83 Fixed price incentive. As prescribed in 1816.406-70(c), insert the following clause: Fixed Price Incentive (OCT 1996) The target cost of this contract is $___. The Target profit of this...

  13. 48 CFR 52.216-5 - Price Redetermination-Prospective.

    Science.gov (United States)

    2010-10-01

    ... exceed any ceiling price included in the contract. (b) Definition. Costs, as used in this clause, means... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Price Redetermination....216-5 Price Redetermination—Prospective. As prescribed in 16.205-4, insert the following clause:...

  14. 48 CFR 1652.216-70 - Accounting and price adjustment.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Accounting and price... of FEHBP Clauses 1652.216-70 Accounting and price adjustment. As prescribed in section 1616.7001, the... (community rated). Accounting and Price Adjustment (JAN 2003) (a) Annual Accounting Statement. The...

  15. 40 CFR 98.216 - Data reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Miscellaneous Uses of Carbonate § 98.216 Data reporting...) Annual CO2 emissions from miscellaneous carbonate use (metric tons). (b) Annual mass of each carbonate... to calculate emissions. (e) If you followed the calculation method of § 98.213(b)(1)(i), you...

  16. 12 CFR Appendix A to Part 216 - Model Privacy Form

    Science.gov (United States)

    2010-01-01

    ... the FCRA and 12 CFR part 222, subpart C, with respect to the initial notice and opt-out and any... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Model Privacy Form A Appendix A to Part 216 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM PRIVACY...

  17. 48 CFR 216.601 - Time-and-materials contracts.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Time-and-materials... SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Time-And-Materials, Labor-Hour, and Letter Contracts 216.601 Time-and-materials contracts. (d) Limitations. (i)...

  18. 50 CFR 216.255 - Requirements for monitoring and reporting.

    Science.gov (United States)

    2010-10-01

    ... ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND... in the Gulf of Mexico § 216.255 Requirements for monitoring and reporting. (a) The Holder of the... mammals that inhabit the northern Gulf of Mexico; (2) Have on-site marine mammal observers approved...

  19. 48 CFR 1852.216-88 - Performance incentive.

    Science.gov (United States)

    2010-10-01

    ... below the standard performance level, the Contractor will either pay the amount due the Government or... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Performance incentive. 1852... 1852.216-88 Performance incentive. As prescribed in 1816.406-70(f), insert the following...

  20. 31 CFR 31.216 - Communications with Treasury employees.

    Science.gov (United States)

    2010-07-01

    ... employee, except as permitted by Government-Wide Ethics Rules, 5 CFR part 2635. (3) Solicit or obtain from... TROUBLED ASSET RELIEF PROGRAM Conflicts of Interest § 31.216 Communications with Treasury employees. (a... employee with personal or direct responsibility for that procurement. (2) Offer, give, or promise to...

  1. Adsorption gas chromatography with 150-ms 216Po

    International Nuclear Information System (INIS)

    A gas chromatography apparatus was developed, which allows experiments with volatile radionuclides having shorter half-lives than one second. This apparatus was tested with the 150-ms isotope 216Po. Experimental data were compared with a Monte Carlo model to determine the adsorption enthalpy ΔHa. (author) 2 figs., 2 refs

  2. 50 CFR 216.45 - General Authorization for Level B harassment for scientific research.

    Science.gov (United States)

    2010-10-01

    ... harassment for scientific research. 216.45 Section 216.45 Wildlife and Fisheries NATIONAL MARINE FISHERIES... Authorization for Level B harassment for scientific research. (a) General Authorization. (1) Persons are..., as defined in § 216.3, for purposes of bona fide scientific research Provided, That: (i) They...

  3. 50 CFR 216.41 - Permits for scientific research and enhancement.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Permits for scientific research and... AND IMPORTING OF MARINE MAMMALS Special Exceptions § 216.41 Permits for scientific research and enhancement. In addition to the requirements under §§ 216.33 through 216.38, permits for scientific...

  4. 20 CFR 408.216 - Are you a World War II veteran?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Are you a World War II veteran? 408.216 Section 408.216 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS SVB Qualification and Entitlement Military Service § 408.216 Are you a World War...

  5. 12 CFR 216.12 - Limits on sharing account number information for marketing purposes.

    Science.gov (United States)

    2010-01-01

    ... third party for use in telemarketing, direct mail marketing, or other marketing through electronic mail... for marketing purposes. 216.12 Section 216.12 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF... Disclosures § 216.12 Limits on sharing account number information for marketing purposes. (a)...

  6. Nuclear structure of 216Ra at high spin

    Indian Academy of Sciences (India)

    S Muralithar; G Rodrigues; R P Singh; R K Bhowmik; P Mukherjee; B Sethi; I Mukherjee

    2012-09-01

    High-spin states of 216Ra ( = 88, = 128) have been investigated through 209Bi(10B, 3n) reaction at an incident beam energy of 55 MeV and 209Bi(11B, 4n) reaction at incident beam energies ranging from 65 to 78 MeV. Based on coincidence data, the level scheme for 216Ra has been considerably extended up to $∼ 33\\hbar$ spin and 7.2 MeV excitation energy in the present experiment with placement of 28 new -transitions over what has been reported earlier. Tentative spin-parity assignments are done for the newly proposed levels on the basis of the DCO ratios corresponding to strong gates. Empirical shell model calculations were carried out to provide an understanding of the underlying nuclear structure.

  7. Existing data on the 216-Z liquid waste sites

    International Nuclear Information System (INIS)

    During 36 years of operation at the Hanford Site, the ground has been used for disposal of liquid and solid transuranic and/or low-level wastes. Liquid waste was disposed in surface and subsurface cribs, trenches, French drains, reverse wells, ditches and ponds. Disposal structures associated with Z Plant received liquid waste from plutonium finishing and reclamation, waste treatment and laboratory operations. The nineteen 216-Z sites have received 83% of the plutonium discharged to 325 liquid waste facilities at the Hanford Site. The purpose of this document is to support the Hanford Defense Waste Environmental Impact Statement by drawing the existing data together for the 216-Z liquid waste disposal sites. This document provides an interim reference while a sitewide Waste Information Data System (WIDS) is developed and put on line. Eventually these and additional site data for all Hanford waste disposal sites will be available on WIDS. Compilation of existing data is the first step in evaluating the need and developing the technology for long-term management of these waste sites. The scope of this document is confined to data describing the status of the 216-Z waste sites as of December 31, 1979. Information and sketches are taken from existing documents and drawings

  8. Addiction-Related Effects of DOV 216,303 and Cocaine

    DEFF Research Database (Denmark)

    Sørensen, Gunnar; Husum, Henriette; Brennum, Lise T;

    2014-01-01

    , and we measured monoamine receptor occupancy as well as brain and plasma exposure. DOV 216,303 was self-administered acutely in the same dose range as cocaine. However, in the CPP model, DOV 216,303 did not induce place preference at doses where cocaine caused place preference. Higher doses of DOV 216......DOV 216,303, an inhibitor of serotonin, noradrenaline and dopamine reuptake, belongs to a new line of drugs called 'triple reuptake inhibitors' that have been proposed for treatment of depression. The addictive drug cocaine has similar mechanism of action and exerts rewarding effects by blocking...... of DOV 216,303, we conducted a comparative study of addiction-related effects of DOV 216,303 and cocaine in mice using acute self-administration, conditioned place preference (CPP) and drug-induced hyperlocomotion. Effects on accumbal extracellular dopamine levels were determined using microdialysis...

  9. 27 CFR 40.216b - Notice for roll-your-own tobacco.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Notice for roll-your-own tobacco. 40.216b Section 40.216b Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) TOBACCO MANUFACTURE OF TOBACCO PRODUCTS, CIGARETTE...

  10. 32 CFR Appendix A of Part 216 - Military Recruiting Sample Letter of Inquiry

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Military Recruiting Sample Letter of Inquiry A Appendix A of Part 216 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF... INSTITUTIONS OF HIGHER EDUCATION Information requirements. Pt. 216, App. A Appendix A of Part...

  11. 12 CFR 216.15 - Other exceptions to notice and opt out requirements.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Other exceptions to notice and opt out requirements. 216.15 Section 216.15 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL..., agencies that are rating you, persons that are assessing your compliance with industry standards, and...

  12. 30 CFR 77.216-5 - Water, sediment or slurry impoundments and impounding structures; abandonment.

    Science.gov (United States)

    2010-07-01

    ..., sediment, or slurry impoundment and impounding structure which meets the requirements of 30 CFR 77.216(a... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Water, sediment or slurry impoundments and... AND SURFACE WORK AREAS OF UNDERGROUND COAL MINES Surface Installations § 77.216-5 Water, sediment...

  13. 50 CFR 216.107 - Incidental harassment authorization for Arctic waters.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Incidental harassment authorization for... Incidental to Specified Activities § 216.107 Incidental harassment authorization for Arctic waters. (a... authorized under § 216.105, incidental harassment authorizations may be issued, following a 30-day...

  14. 50 CFR 216.108 - Requirements for monitoring and reporting under incidental harassment authorizations for Arctic...

    Science.gov (United States)

    2010-10-01

    ... under incidental harassment authorizations for Arctic waters. 216.108 Section 216.108 Wildlife and... for monitoring and reporting under incidental harassment authorizations for Arctic waters. (a) Holders of an incidental harassment authorization in Arctic waters and their employees, agents, and...

  15. 48 CFR 216.405-1 - Cost-plus-incentive-fee contracts.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Cost-plus-incentive-fee... REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 216.405-1 Cost-plus-incentive-fee contracts. See PGI 216.405-1 for guidance on the use of...

  16. 50 CFR 216.21 - Actions permitted by international treaty, convention, or agreement.

    Science.gov (United States)

    2010-10-01

    ..., convention, or agreement. 216.21 Section 216.21 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE... international treaty, convention, or agreement. The MMPA and these regulations shall not apply to the extent that they are inconsistent with the provisions of any international treaty, convention or agreement,...

  17. Removal of Uranium in Drinking Water: Brimac Environmental Services, Inc. Brimac HA 216 Adsorptive Media

    Science.gov (United States)

    The Brimac HA 216 Adsorptive Media was tested for uranium (U) removal from a drinking water source (well water) at Grappone Toyota located in Bow, New Hampshire. The HA 216 media is a hydroxyapatite-based material. A pilot unit, consisting of a TIGG Corporation Cansorb® C-5 ste...

  18. 48 CFR 52.216-16 - Incentive Price Revision-Firm Target.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Incentive Price Revision-Firm Target. 52.216-16 Section 52.216-16 Federal Acquisition Regulations System FEDERAL ACQUISITION... liquidation of progress payments, then that portion may, instead of being refunded, be added to...

  19. 48 CFR 52.216-17 - Incentive Price Revision-Successive Targets.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Incentive Price Revision-Successive Targets. 52.216-17 Section 52.216-17 Federal Acquisition Regulations System FEDERAL ACQUISITION... liquidation of progress payments, then that portion may, instead of being refunded, be added to...

  20. 20 CFR 216.32 - Who is eligible for a disability annuity.

    Science.gov (United States)

    2010-04-01

    ... retirement age; and (2) Has a current connection with the railroad industry; and has either: (3) Completed 20....32 Section 216.32 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT ELIGIBILITY FOR AN ANNUITY Employee Annuity § 216.32 Who is eligible for a disability...

  1. 20 CFR 216.52 - Who is eligible for an annuity as a divorced spouse.

    Science.gov (United States)

    2010-04-01

    ...) Have attained retirement age; or (e) Have attained age 62 but be under retirement age. The annuity is reduced for each month the spouse is under retirement age at the time the annuity begins. ... spouse. 216.52 Section 216.52 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER...

  2. 20 CFR 216.23 - Work which does not affect eligibility.

    Science.gov (United States)

    2010-04-01

    ... RETIREMENT ACT ELIGIBILITY FOR AN ANNUITY Railroad and Last Non-Railroad Employment § 216.23 Work which does... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Work which does not affect eligibility. 216... his or her annuity: (a) Work for a railway labor organization. An individual may work for a...

  3. 32 CFR Appendix B to Part 216 - ROTC Sample Letter of Inquiry

    Science.gov (United States)

    2010-07-01

    ... INSTITUTIONS OF HIGHER EDUCATION Pt. 216, App. B Appendix B to Part 216—ROTC Sample Letter of Inquiry (Tailor letter to situation presented) Dr. Jane Smith, President, ABC University, Anywhere, USA 12345-9876. Dear... institution of higher education, or to an individual, to be available solely for student financial...

  4. 22 CFR 216.9 - Bilateral and multilateral studies and concise reviews of environmental issues.

    Science.gov (United States)

    2010-04-01

    ... reviews of environmental issues. 216.9 Section 216.9 Foreign Relations AGENCY FOR INTERNATIONAL... environmental issues. Notwithstanding anything to the contrary in these procedures, the Administrator may... United States is a member or participant; or (b) Concise reviews of the environmental issues...

  5. 50 CFR 216.13 - Prohibited uses, possession, transportation, sales, and permits.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Prohibited uses, possession, transportation, sales, and permits. 216.13 Section 216.13 Wildlife and Fisheries NATIONAL MARINE FISHERIES..., possession, transportation, sales, and permits. It is unlawful for: (a) Any person to use any port, harbor...

  6. 1 CFR 21.6 - Notice of expiration of codified material.

    Science.gov (United States)

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Notice of expiration of codified material. 21.6 Section 21.6 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL... expiration of codified material. Whenever a codified regulation expires after a specified period by its...

  7. Ataxia and Hypogonadotropic Hypogonadism with Intrafamilial Variability Caused by RNF216 Mutation.

    Science.gov (United States)

    Alqwaifly, Mohammed; Bohlega, Saeed

    2016-06-15

    Gordon Holmes syndrome (GHS) is a distinct phenotype of autosomal recessive cerebellar ataxia, characterized by ataxia, dementia, reproductive defects and hypogonadism; it has been recently found to be associated with RNF216 mutation. We performed whole-exome sequencing and filtered the resulting novel variants by the coordinates of the shared autozygome. We identified a novel splicing variant in RNF216 that is likely to abolish the canonical splice site at the junction of exon/intron 13 (NM_207111.3:c.2061G>A). We herein report two patients with GHS caused by a novel RNF216 mutation as the first follow up report on RNF216-related GHS, and show interfamilial variability of phenotype supporting the previously reported RNF216-related cases. PMID:27441066

  8. Groundwater impact assessment report for the 216-U-14 Ditch

    Energy Technology Data Exchange (ETDEWEB)

    Singleton, K.M.; Lindsey, K.A.

    1994-01-01

    Groundwater impact assessments are conducted at liquid effluent receiving sites on the Hanford Site to determine hydrologic and contaminant impacts caused by discharging wastewater to the soil column. The assessments conducted are pursuant to the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement) Milestone M-17-00A and M-17-00B, as agreed by the US Department of Energy (DOE), Washington State Department of Ecology (Ecology), and the US Environmental Protection Agency (EPA) (Ecology et al. 1992). This report assesses impacts on the groundwater and vadose zone from wastewater discharged to the 216-U-14 Ditch. Contemporary effluent waste streams of interest are 242-S Evaporator Steam Condensate and UO{sub 3}/U Plant wastewater.

  9. 40 CFR 80.216 - What standards apply to gasoline produced or imported for use in the GPA?

    Science.gov (United States)

    2010-07-01

    ... produced or imported for use in the GPA? 80.216 Section 80.216 Protection of Environment ENVIRONMENTAL... Geographic Phase-in Program § 80.216 What standards apply to gasoline produced or imported for use in the GPA... in the geographic phase-in area under § 80.215, and designated as GPA gasoline under §...

  10. 32 CFR 724.216 - Failure to appear at a hearing or respond to a scheduling notice.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Failure to appear at a hearing or respond to a scheduling notice. 724.216 Section 724.216 National Defense Department of Defense (Continued) DEPARTMENT OF... § 724.216 Failure to appear at a hearing or respond to a scheduling notice. (a) Except as...

  11. An analysis of 216 cases of syncope%晕厥216例临床分析

    Institute of Scientific and Technical Information of China (English)

    周影

    2013-01-01

      Objective To analyze the clinical features, precipitating factors and potential risks of patients with syncope. Methods The methods of retrospective study were used to analyze the clinical data of 216 cases of syncope. Results There were 170 cases of neural reflex syncope (accounting for 79 percent of the total cases) and 46 cases of syncope caused by organic diseases (accounting for 21 percent of the total cases). Conclusion Generally an episode of syncope is the result of transient cerebral dysfunction, which is a benign course without any sequela. However, as for the young, the people with basic diseases (such as hypertension, diabetes mellitus, coronary heart disease, etc.) and the aged, an episode of syncope implies severe cardiac, cerebral and other organs' dysfunction of the patients, which demands emergency treatment to save lives.%  目的分析晕厥患者的临床特点、诱发因素、潜在风险。方法回顾性分析216例晕厥患者的临床资料。结果神经反射性晕厥170例,占发病人数的79%;器质性疾病所致晕厥46例,占发病人数的21%。结论晕厥通常为一过性脑功能障碍,发作后无后遗症,呈良性经过。但部分年轻人,合并高血压、糖尿病、冠心病等基础疾病者,老年人发生晕厥,提示已有严重的心、脑及其他器官功能损害,需要紧急处理,否则威胁患者生命。

  12. State Environmental Policy Act (SEPA) Environmental Checklist Form 216-B-3 Expansion Ponds Closure Plan

    International Nuclear Information System (INIS)

    The 216-B-3 Expansion Ponds Closure Plan (Revision 1) consists of a Part A Dangerous Waste Permit Application and a Resource Conservation and Recovery Act Closure Plan. An explanation of the Part A submitted with this document is provided at the beginning of the Part A Section. The closure plan consists of nine chapters and five appendices. The 216-B-3 Pond System consists of a series of four earthen, unlined, interconnected ponds and the 216-B-3-3 Ditch that receive waste water from various 200 East Area operating facilities. These four ponds, collectively. Waste water (primarily cooling water, steam condensate, and sanitary water) from various 200 East Area facilities is discharged to the 216-B-3-3 Ditch. Water discharged to the 216-8-3-3 Ditch flows directly into the 216-B-3 Pond. In the past, waste water discharges to B Pond and the 216-B-3-3 Ditch contained mixed waste (radioactive waste and dangerous waste). The radioactive portion of mixed waste has been interpreted by the US Department of Energy (DOE) to be regulated under the Atomic Energy Act of 1954; the nonradioactive dangerous portion of mixed waste is regulated under RCRA. Mixed waste also may be considered a hazardous substance under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) when considering remediation of waste sites

  13. 40 CFR 90.903 - Exclusions, application of section 216 (10) and (11) of the Act.

    Science.gov (United States)

    2010-07-01

    ... section 216(10) of the Act, an internal combustion engine (including the fuel system) that is not used in a motor vehicle is deemed a nonroad engine, if it meets the definition in subpart A of this...

  14. 40 CFR 89.903 - Application of section 216(10) of the Act.

    Science.gov (United States)

    2010-07-01

    ... the applicability of section 216(10) of the Act, an internal combustion engine (including the fuel system) that is not used in a motor vehicle is deemed a nonroad engine if it meets the definition...

  15. Guillem Fabre, “Pus dels majors” (BdT 216.2; Id., “Hon mais vey, pus truep sordeyor” (BdT 216.1

    Directory of Open Access Journals (Sweden)

    Linda Paterson

    2013-03-01

    Full Text Available The historical circumstances of Guillem Fabre’s two surviving sirventes has given rise to widely divergent views. This essay builds on Parducci’s contextualisation of BdT 216.2 during the War of the Sicilian Vespers and the so-called Aragonese crusade by the French against Pere III of Aragon in 1284-1285. It argues that Guillem is likely to be referring to events say entre nos because Narbonne was the focal point of the gathering French army and preaching of the crusade. All other textual details are compatible with this period and best explained by this context. But while Parducci places the sirventes in May 1285, it must in fact have preceded the death of Martin IV on 29 March, since his speedily-appointed successor Honorius IV could not be blamed for not having preached a crusade against the heathen before the conflict degenerated into further atrocities. Furthermore a slightly earlier timing better explains the allusion to “the best-known man in the world”, the obvious candidate at this time being Charles of Anjou. Guillem probably composed BdT 216.2 during the build-up to war in 1284, before the death of Charles in January 1285, during the period of war preparations and propaganda speeches. It is also argued here that, pace Parducci, BdT 216.1 did not necessarily precede BdT 216.2.

  16. Interim-status groundwater monitoring plan for the 216-B-63 trench. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Sweeney, M.D.

    1995-06-13

    This document outlines the groundwater monitoring plan for interim-status detection-level monitoring of the 216-B-63 Trench. This is a revision of the initial groundwater monitoring plan prepared for Westinghouse Hanford Company (WHC) by Bjornstad and Dudziak (1989). The 216-B-63 Trench, located at the Hanford Site in south-central Washington State, is an open, unlined, earthern trench approximately 1.2 m (4 ft) wide at the bottom, 427 m (1400 ft) long, and 3 m (10 ft) deep that received wastewater containing hazardous waste and radioactive materials from B Plant, located in the 200 East Area. Liquid effluent discharge to the 216-B-63 Trench began in March 1970 and ceased in February 1992. The trench is now managed by Waste Tank Operations.

  17. Groundwater impact assessment report for the 216-S-26 Crib, 200 West Area

    Energy Technology Data Exchange (ETDEWEB)

    Lindberg, J.W.; Evelo, S.D.; Alexander, D.J.

    1993-11-01

    This report assesses the impact of wastewater discharged to the 216-S-26 Crib on groundwater quality. The 216-S-26 Crib, located in the southern 200 West Area, has been in use since 1984 to dispose of liquid effluents from the 222-S Laboratory Complex. The 222-S Laboratory Complex effluent stream includes wastewater from four sources: the 222-S Laboratory, the 219-S Waste Storage Facility, the 222-SA Chemical Standards Laboratory, and the 291-S Exhaust Fan Control House and Stack. Based on assessment of groundwater chemistry and flow data, contaminant transport predictions, and groundwater chemistry data, the 216-S-26 Crib has minimal influence on groundwater contamination in the southern 200 West Area.

  18. Groundwater impact assessment report for the 216-S-26 Crib, 200 West Area

    International Nuclear Information System (INIS)

    This report assesses the impact of wastewater discharged to the 216-S-26 Crib on groundwater quality. The 216-S-26 Crib, located in the southern 200 West Area, has been in use since 1984 to dispose of liquid effluents from the 222-S Laboratory Complex. The 222-S Laboratory Complex effluent stream includes wastewater from four sources: the 222-S Laboratory, the 219-S Waste Storage Facility, the 222-SA Chemical Standards Laboratory, and the 291-S Exhaust Fan Control House and Stack. Based on assessment of groundwater chemistry and flow data, contaminant transport predictions, and groundwater chemistry data, the 216-S-26 Crib has minimal influence on groundwater contamination in the southern 200 West Area

  19. 50 CFR 216.46 - U.S. citizens on foreign flag vessels operating under the International Dolphin Conservation...

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false U.S. citizens on foreign flag vessels operating under the International Dolphin Conservation Program. 216.46 Section 216.46 Wildlife and Fisheries....46 U.S. citizens on foreign flag vessels operating under the International Dolphin...

  20. 50 CFR 216.16 - Prohibitions under the General Authorization for Level B harassment for scientific research.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Prohibitions under the General Authorization for Level B harassment for scientific research. 216.16 Section 216.16 Wildlife and Fisheries... Prohibitions under the General Authorization for Level B harassment for scientific research. It shall...

  1. 48 CFR 2452.216-70 - Estimated cost, base fee and award fee.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Estimated cost, base fee... Provisions and Clauses 2452.216-70 Estimated cost, base fee and award fee. As prescribed in 2416.406(e)(1), insert the following clause in all cost-plus-award-fee contracts: Estimated Cost, Base Fee and Award...

  2. 50 CFR 216.95 - Official mark for “Dolphin-safe” tuna products.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Official mark for âDolphin-safeâ tuna... AND IMPORTING OF MARINE MAMMALS Dolphin Safe Tuna Labeling § 216.95 Official mark for “Dolphin-safe... Department of Commerce that may be used to label tuna products that meet the “dolphin-safe” standards...

  3. 30 CFR 77.216-4 - Water, sediment or slurry impoundments and impounding structures; reporting requirements...

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Water, sediment or slurry impoundments and....216-4 Water, sediment or slurry impoundments and impounding structures; reporting requirements... of the initial plan approval, the person owning, operating, or controlling a water, sediment,...

  4. 30 CFR 77.216-1 - Water, sediment or slurry impoundments and impounding structures; identification.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Water, sediment or slurry impoundments and... AND SURFACE WORK AREAS OF UNDERGROUND COAL MINES Surface Installations § 77.216-1 Water, sediment or..., operating, or controlling the structure, shall be located on or immediately adjacent to each water,...

  5. 30 CFR 77.216-3 - Water, sediment, or slurry impoundments and impounding structures; inspection requirements...

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Water, sediment, or slurry impoundments and... COAL MINES Surface Installations § 77.216-3 Water, sediment, or slurry impoundments and impounding structures; inspection requirements; correction of hazards; program requirements. (a) All water, sediment,...

  6. 30 CFR 77.216 - Water, sediment, or slurry impoundments and impounding structures; general.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Water, sediment, or slurry impoundments and... WORK AREAS OF UNDERGROUND COAL MINES Surface Installations § 77.216 Water, sediment, or slurry... structures which impound water, sediment, or slurry shall be required if such an existing or...

  7. 76 FR 27987 - Foreign-Trade Zone 216-Olympia, Washington; Application for Reorganization Under Alternative Site...

    Science.gov (United States)

    2011-05-13

    ... zone under the alternative site framework (ASF) adopted by the Board (74 FR 1170, 1/12/09 (correction 74 FR 3987, 1/22/09); 75 FR 71069-71070, 11/22/10). The ASF is an option for grantees for the..., 2011. FTZ 216 was approved by the Board on August 16, 1996 (Board Order 836, 61 FR 45408,...

  8. Interim-status groundwater monitoring plan for the 216-B-63 trench

    Energy Technology Data Exchange (ETDEWEB)

    Sweeney, M.D.

    1995-02-09

    This document outlines the groundwater monitoring plan, under RCRA regulations in 40 CFR 265 Subpart F and WAC173-300-400, for the 216-B-63 Trench. This interim status facility is being sampled under detection monitoring criteria and this plan provides current program conditions and requirements.

  9. 20 CFR 216.67 - “Child in care.”

    Science.gov (United States)

    2010-04-01

    ... is payable based upon having the child in care. (b) Social Security Act. In order to establish...” found in the Social Security Act is used. Under this definition, a child must be under age 16 or under a... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false âChild in care.â 216.67 Section...

  10. 50 CFR 216.22 - Taking by State or local government officials.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Taking by State or local government... AND IMPORTING OF MARINE MAMMALS General Exceptions § 216.22 Taking by State or local government officials. (a) A State or local government official or employee may take a marine mammal in the...

  11. 48 CFR 1852.216-73 - Estimated cost and cost sharing.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Estimated cost and cost... and Clauses 1852.216-73 Estimated cost and cost sharing. As prescribed in 1816.307-70(a), insert the following clause: Estimated Cost and Cost Sharing (DEC 1991) (a) It is estimated that the total cost...

  12. 48 CFR 1852.216-84 - Estimated cost and incentive fee.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Estimated cost and... Provisions and Clauses 1852.216-84 Estimated cost and incentive fee. As prescribed in 1816.406-70(d), insert the following clause: Estimated Cost and Incentive Fee (OCT 1996) The target cost of this contract...

  13. 48 CFR 1852.216-85 - Estimated cost and award fee.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Estimated cost and award... and Clauses 1852.216-85 Estimated cost and award fee. As prescribed in 1816.406-70(e), insert the following clause: Estimated Cost and Award Fee (SEP 1993) The estimated cost of this contract is $___....

  14. 48 CFR 1552.216-76 - Estimated cost and cost-sharing.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Estimated cost and cost... 1552.216-76 Estimated cost and cost-sharing. As prescribed in 1516.307(c), insert the following clause: Estimated Cost and Cost-Sharing (APR 1996) (a) The total estimated cost of performing the work under...

  15. 48 CFR 2452.216-77 - Estimated quantities-requirements contract.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Estimated quantities... Provisions and Clauses 2452.216-77 Estimated quantities—requirements contract. As prescribed in 2416.506-70(c), insert the following provision: Estimated Quantities—Requirements Contract (FEB 2006) In accordance...

  16. 48 CFR 1852.216-74 - Estimated cost and fixed fee.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Estimated cost and fixed... and Clauses 1852.216-74 Estimated cost and fixed fee. As prescribed in 1816.307-70(b), insert the following clause: Estimated Cost and Fixed Fee (DEC 1991) The estimated cost of this contract...

  17. 20 CFR 216.22 - Work as an employee which affects payment.

    Science.gov (United States)

    2010-04-01

    ... RETIREMENT ACT ELIGIBILITY FOR AN ANNUITY Railroad and Last Non-Railroad Employment § 216.22 Work as an employee which affects payment. (a) Work for a railroad employer. Work for pay as an employee of a railroad... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Work as an employee which affects...

  18. 20 CFR 216.24 - Relinquishment of rights to return to work.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Relinquishment of rights to return to work... RETIREMENT ACT ELIGIBILITY FOR AN ANNUITY Railroad and Last Non-Railroad Employment § 216.24 Relinquishment of rights to return to work. (a) What return to work rights must be given up. Before an...

  19. 50 CFR 216.250 - Specified activity and specified geographical region.

    Science.gov (United States)

    2010-10-01

    ... OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE... Weapon Missions in the Gulf of Mexico § 216.250 Specified activity and specified geographical region. (a... within the Eglin Air Force Base Gulf Test and Training Range within the northern Gulf of Mexico....

  20. 50 CFR 216.211 - Specified activity and specified geographical region.

    Science.gov (United States)

    2010-10-01

    ... OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE.... Gulf of Mexico § 216.211 Specified activity and specified geographical region. (a) Regulations in this... Mexico adjacent to the coasts of Texas, Mississippi, Louisiana, Alabama, and Florida. The incidental,...

  1. 20 CFR 725.216 - Determination of relationship; surviving divorced spouse.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determination of relationship; surviving... Benefits) § 725.216 Determination of relationship; surviving divorced spouse. An individual will be considered to be the surviving divorced spouse of a deceased miner in a claim considered under this part...

  2. 20 CFR 216.66 - Who is an employee's surviving divorced spouse.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Who is an employee's surviving divorced... RAILROAD RETIREMENT ACT ELIGIBILITY FOR AN ANNUITY Widow(er), Surviving Divorced Spouse, and Remarried Widow(er) Annuities § 216.66 Who is an employee's surviving divorced spouse. An individual who...

  3. Groundwater impact assessment for the 216-U-17 Crib, 200 West Area

    International Nuclear Information System (INIS)

    As required by the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement milestone M-17-00A), this report assesses the impact to groundwater from discharge of process condensate to the ground at the 216-U-17 Crib. The assessment considers impacts associated with moisture movement through soil beneath the crib and the potential transport of contaminants to the groundwater

  4. Groundwater impact assessment for the 216-U-17 Crib, 200 West Area

    Energy Technology Data Exchange (ETDEWEB)

    Reidel, S.P.; Johnson, V.G.; Kline, N.W.

    1993-06-01

    As required by the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement milestone M-17-00A), this report assesses the impact to groundwater from discharge of process condensate to the ground at the 216-U-17 Crib. The assessment considers impacts associated with moisture movement through soil beneath the crib and the potential transport of contaminants to the groundwater.

  5. 12 CFR 216.4 - Initial privacy notice to consumers required.

    Science.gov (United States)

    2010-01-01

    ... consumer's loan. (d) Existing customers. When an existing customer obtains a new financial product or... SYSTEM PRIVACY OF CONSUMER FINANCIAL INFORMATION (REGULATION P) Privacy and Opt Out Notices § 216.4... provided in paragraph (e) of this section; and (2) Consumer. A consumer, before you disclose any...

  6. 19 CFR 146.52 - Manipulation, manufacture, exhibition or destruction; Customs Form 216.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Manipulation, manufacture, exhibition or... Merchandise in a Zone § 146.52 Manipulation, manufacture, exhibition or destruction; Customs Form 216. (a... approved manipulation, manufacture, exhibition, or certification of destruction (other than by a...

  7. 33 CFR 110.216 - Pacific Ocean at Santa Catalina Island, Calif.

    Science.gov (United States)

    2010-07-01

    ... HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.216 Pacific Ocean at Santa...°19′16.7″ W. (b) The regulations. (1) The Descanso Bay anchorage is reserved for yachts and other.... Fixed mooring piles or stakes are prohibited. (2) The Isthmus Cove anchorage shall be available...

  8. 29 CFR 825.216 - Limitations on an employee's right to reinstatement.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Limitations on an employee's right to reinstatement. 825... Family and Medical Leave Act § 825.216 Limitations on an employee's right to reinstatement. (a) An employee has no greater right to reinstatement or to other benefits and conditions of employment than...

  9. Regulation of the P2X7R by microRNA-216b in human breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Zheng, Luming [Department of Breast and Thyroid, Jinan Military General Hospital, Jinan 250031, Shandong Province (China); Zhang, Xukui [Department of General Surgery, Jinan Military General Hospital, Jinan 250031, Shandong Province (China); Yang, Feng [Department of General Surgery, Shanghai Ninth People’s Hospital, Shanghai 200011 (China); Zhu, Jian; Zhou, Peng; Yu, Fang; Hou, Lei; Xiao, Lei; He, Qingqing [Department of Breast and Thyroid, Jinan Military General Hospital, Jinan 250031, Shandong Province (China); Wang, Baocheng, E-mail: wangbaocheng4w4@163.com [Department of Oncology, Jinan Military General Hospital, Jinan 250031, Shandong Province (China)

    2014-09-12

    Highlights: • We suggest the expression level of miR-216b and P2X7R in breast cancer tissues and cell lines. • We demonstrated that miR-216b directly targets and inhibits P2X7R. • We suggested miR-216b can attenuate ATP/P2X7R signaling pathways and induced Bcl-2/caspase-3 pathway. - Abstract: Breast cancer is the most common cancer in women around the world. However, the molecular mechanisms underlying breast cancer pathogenesis are only partially understood. Here, in this study, we found that P2X7R was up-regulated and miR-216b was down-regulated in breast cancer cell lines and tissues. Using bioinformatic analysis and 3′UTR luciferase reporter assay, we determined P2X7R can be directly targeted by miR-216b, which can down-regulate endogenous P2X7R mRNA and protein levels. Ectopic expression of miR-216b mimics leads to inhibited cell growth and apoptosis, while blocking expression of the miR-216b results in increased cell proliferation. Furthermore, our findings demonstrate that knockdown of P2X7R promotes apoptosis in breast cancer cells through down-regulating Bcl-2 and increasing the cleavage caspase-3 protein level. Finally, we confirmed that down-regulation of miR-216b in breast cancer is inversely associated with P2X7R expression level. Together, these findings establish miR-216b as a novel regulator of P2X7R and a potential therapeutic target for breast cancer.

  10. 216例合并HIV/AIDS患者围手术期的心理护理

    Institute of Scientific and Technical Information of China (English)

    韦庆旭

    2014-01-01

    目的:通过对216例合并HIV/AIDS患者围手术期的心理护理,探讨合并HIV/AIDS患者围手术期的心理护理方法。方法:对216例合并HIV/AIDS患者进行术前、术中、术后心理护理和随访。结果通过对216例合并HIV/AIDS患者的心理护理,减轻了心理负担疗效果好,达满意。

  11. Features of thin spatial structure of the quasar 3C216 at decameter lengths of waves

    Science.gov (United States)

    Megn, A. V.; Rashkovskiy, S. L.; Shepelev, V. A.; Inytin, G. A.; Vashchishin, R. V.; Brazhenko, A. I.; Koshoviy, V. V.; Lozinskiy, A. B.

    2010-01-01

    The results of interferometric researches of the quasar 3C216 have been presented. The model of brightness distribution of the quasar at frequencies of 20 and 25 MHz and spectra of its details at frequencies below 1 GHz have been refined. It was found out, that at decameter lengths the radio image of 3C216 has three components. It consists of a compact component having the size limited by scattering, an extended component with the size of 4.5'' and a halo with the size about 23''. The northeast hot spot (instead of the core, as it was supposed earlier) is the dominating compact component at decameter waves. The self-absorption effect in the northeast hot spot has been detected.

  12. Borehole Summary Report for the 216-B-2-2 Ditch

    International Nuclear Information System (INIS)

    The purpose of this borehole summary report is to provide the results of the drilling and sampling as a data package. The 216-B-2-2 Ditch borehole data will be evaluated with other existing data during remedial investigation/feasibility study (RI/FS) work plan development for the Gable Mountain Pond/B-Pond and Ditches Cooling Water Group (200-CW-1 ). Additional characterization needs for the ditch, as well as for the 200-CW-1 Waste Group in general, will be defined in an RI/FS work plan for the 200-CW-1 Waste Group planned for preparation in fiscal year 1999. After characterization activities have been completed for the waste group, the information (including the 216-B-2-2 borehole data) will be collectively evaluated and documented in a remedial investigation report

  13. Hirschsprung′s disease: Role of rectal suction biopsy - data on 216 specimens

    OpenAIRE

    Rahman Zillur; Hannan Jafrul; Islam Saiful

    2010-01-01

    Background: The diagnosis of Hirschsprung′s disease (HD) is dependent on the histological study of rectal ganglion cells, and an open rectal biopsy was the mainstay that required general anaesthesia (GA) and carried risk of postoperative rectal bleeding. Suction rectal biopsy later gained wide acceptance and became the choice as there is no requirement of GA and virtual absence of any complications. Materials and Methods: A retrospective review of the histological findings of 216 recta...

  14. Hirschsprung’s disease: Role of rectal suction biopsy - data on 216 specimens

    OpenAIRE

    Rahman, Zillur; Hannan, Jafrul; Saiful ISLAM

    2010-01-01

    Background: The diagnosis of Hirschsprung’s disease (HD) is dependent on the histological study of rectal ganglion cells, and an open rectal biopsy was the mainstay that required general anaesthesia (GA) and carried risk of postoperative rectal bleeding. Suction rectal biopsy later gained wide acceptance and became the choice as there is no requirement of GA and virtual absence of any complications. Materials and Methods: A retrospective review of the histological findings of 216 rectal sucti...

  15. 47 CFR 15.242 - Operation in the bands 174-216 MHz and 470-668 MHz.

    Science.gov (United States)

    2010-10-01

    ... bands 174-216 MHz and 470-668 MHz. (a) The marketing and operation of intentional radiators under the... implementation of the digital television services. The operating frequencies of the part 15 devices may need...

  16. 77 FR 29682 - Gulf of Mexico, Outer Continental Shelf, Central Planning Area, Oil and Gas Lease Sale 216/222

    Science.gov (United States)

    2012-05-18

    ... Availability (NOA) of a Record of Decision (ROD) on a Final Supplemental Environmental Impact Statement (SEIS... Area (CPA) Lease Sale 216/222 Authority: This NOA is published pursuant to the regulations (40 CFR...

  17. H_2^{16}O and H_2^{18}O Maser Emission from Gas-Dust Clouds

    CERN Document Server

    Nesterenok, Aleksandr; 10.1134/S1063773711070036

    2011-01-01

    The collisional pumping of H_2^{16}O and H_2^{18}O masers in hot dense gas-dust clouds has been simulated numerically. New data on the rate coefficients for collisional transitions from Faure et al. (2007) were used in the calculations. The possibility of detecting H_2^{18}O emission in 22.2-GHz H_2^{16}O maser sources is investigated. The medium is shown to become optically thick in the H_2^{16}O lines for which an inverted level population is observed at H_2O column densities of ~10^{19}-10^{20} cm^{-2}. A simultaneous observation of H_2^{18}O emission and H_2^{16}O maser emission in the same source will allow the physical conditions in the gas-dust cloud to be refined.

  18. DDO216-A1: a central globular cluster in a low-luminosity transition type galaxy

    CERN Document Server

    Cole, Andrew A; Skillman, Evan D; Williams, Benjamin F; Dolphin, Andrew E; Johnson, L Clifton; McConnachie, Alan W; Boylan-Kolchin, Michael; Dalcanton, Julianne; Governato, Fabio; Madau, Piero; Shen, Sijing; Vogelsberger, Mark

    2016-01-01

    We confirm that the object DDO216-A1 is a substantial globular cluster at the center of Local Group galaxy DDO216 (the Pegasus dwarf irregular), using Hubble Space Telescope ACS imaging. By fitting isochrones, we find the cluster metallicity to be -1.6 +/-0.2, for reddening E(B-V) = 0.16 +/-0.02; the best-fit age is 12.3 +/-0.8 Gyr. There are ~30 RR Lyrae variables in the cluster; the magnitude of the fundamental mode pulsators gives a distance modulus of 24.77 +/-0.08 - identical to the host galaxy. The ratio of overtone to fundamental mode variables and their mean periods make DDO216-A1 an Oosterhoff Type I cluster. We find an I-band central surface brightness 20.85 +/-0.17 F814W mag per square arcsecond, half-light radius of 3.1 arcsec (13.4 pc), and absolute magnitude M814 = -7.90 +/-0.16 (approximately 10^5 solar masses). King models fit to the cluster give the core radius and concentration index, r_c = 2.1" +/-0.9" and c = 1.24 +/-0.39. The cluster is an "extended" cluster somewhat typical of some dwarf...

  19. Definitive ideal-gas thermochemical functions of the H$_2$$^{16}$O molecule

    CERN Document Server

    Furtenbacher, Tibor; Hruby, Jan; Kyuberis, Aleksandra A; Zobov, Nikolai F; Polyansky, Oleg L; Tennyson, Jonathan; Császár, Attila G

    2016-01-01

    $Q_{\\rm int}$($T$), of the H$_2$$^{16}$O molecule is reported for temperatures between 0 and 6000 K. Determination of $Q_{\\rm int}$($T$) is principally based on the direct summation technique involving all accurate experimental energy levels known for H$_2$$^{16}$O (almost 20~000 rovibrational energies including an almost complete list up to a relative energy of 7500 \\cm), augmented with a less accurate but complete list of first-principles computed rovibrational energy levels up to the first dissociation limit, about 41~000 \\cm\\ (the latter list includes close to one million bound rovibrational energy levels up to $J = 69$, where $J$ is the rotational quantum number). Partition functions are developed for {\\it ortho}- and {\\it para}-H$_2$$^{16}$O as well as for their equilibrium mixture. Unbound rovibrational states above the first dissociation limit are considered using an approximate model treatment. The effect of the excited electronic states on the thermochemical functions is neglected, as their contribu...

  20. miR-216a regulates snx5, a novel notch signaling pathway component, during zebrafish retinal development.

    Science.gov (United States)

    Olena, Abigail F; Rao, Mahesh B; Thatcher, Elizabeth J; Wu, Shu-Yu; Patton, James G

    2015-04-01

    Precise regulation of Notch signaling is essential for normal vertebrate development. Mind bomb (Mib) is a ubiquitin ligase that is required for activation of Notch by Notch׳s ligand, Delta. Sorting Nexin 5 (SNX5) co-localizes with Mib and Delta complexes and has been shown to directly bind to Mib. We show that microRNA-216a (miR-216a) is expressed in the retina during early development and regulates snx5 to precisely regulate Notch signaling. miR-216a and snx5 have complementary expression patterns. Knocking down miR-216a and/or overexpression of snx5 resulted in increased Notch activation. Conversely, knocking down snx5 and/or miR-216a overexpression caused a decrease in Notch activation. We propose a model in which SNX5, precisely controlled by miR-216a, is a vital partner of Mib in promoting endocytosis of Delta and subsequent activation of Notch signaling.

  1. φX216, a P2-like bacteriophage with broad Burkholderia pseudomallei and B. mallei strain infectivity

    Directory of Open Access Journals (Sweden)

    Kvitko Brian H

    2012-12-01

    Full Text Available Abstract Background Burkholderia pseudomallei and B. mallei are closely related Category B Select Agents of bioterrorism and the causative agents of the diseases melioidosis and glanders, respectively. Rapid phage-based diagnostic tools would greatly benefit early recognition and treatment of these diseases. There is extensive strain-to-strain variation in B. pseudomallei genome content due in part to the presence or absence of integrated prophages. Several phages have previously been isolated from B. pseudomallei lysogens, for example φK96243, φ1026b and φ52237. Results We have isolated a P2-like bacteriophage, φX216, which infects 78% of all B. pseudomallei strains tested. φX216 also infects B. mallei, but not other Burkholderia species, including the closely related B. thailandensis and B. oklahomensis. The nature of the φX216 host receptor remains unclear but evidence indicates that in B. mallei φX216 uses lipopolysaccharide O-antigen but a different receptor in B. pseudomallei. The 37,637 bp genome of φX216 encodes 47 predicted open reading frames and shares 99.8% pairwise identity and an identical strain host range with bacteriophage φ52237. Closely related P2-like prophages appear to be widely distributed among B. pseudomallei strains but both φX216 and φ52237 readily infect prophage carrying strains. Conclusions The broad strain infectivity and high specificity for B. pseudomallei and B. mallei indicate that φX216 will provide a good platform for the development of phage-based diagnostics for these bacteria.

  2. Post-Closure RCRA Groundwater Monitoring Plan for the 216-S-10 Pond and Ditch

    International Nuclear Information System (INIS)

    The purpose of this plan is to provide a post-closure groundwater monitoring program for the 216-S-10 Pond and Ditch (S-10) treatment, storage, and/or disposal (TSD) unit. The plan incorporates the sum of knowledge about the potential for groundwater contamination to originate from the S-10, including groundwater monitoring results, hydrogeology, and operational history. The S-10 has not received liquid waste since October 1991. The closure of S-10 has been coordinated with the 200-CS-1 source operable unit in accordance with the Tri-Party Agreement interim milestones M-20-39 and M-15-39C. The S-10 is closely situated among other waste sites of very similar operational histories. The proximity of the S-10 to the other facilities (216-S-17 pond, 216-S-11 Pond, 216-S-5,6 cribs, 216-S-16 ditch and pond, and 216-U-9 ditch) indicate that at least some observed groundwater contamination beneath and downgradient of S-10 could have originated from waste sites other than S-10. Hence, it may not be feasible to strictly discriminate between the contributions of each waste site to groundwater contamination beneath the S-10. A post-closure groundwater monitoring network is proposed that will include the drilling of three new wells to replace wells that have gone dry. When completed, the revised network will meet the intent for groundwater monitoring network under WAC 173-303-645, and enable an improved understanding of groundwater contamination at the S-10. Site-specific sampling constituents are based on the dangerous waste constituents of concern relating to RCRA TSD unit operations (TSD unit constituents) identified in the Part A Permit Application. Thus, a constituent is selected for monitoring if it is: A dangerous waste constituent identified in the Part A Permit Application, or A mobile decomposition product (i.e., nitrate from nitrite) of a Part A constituent, or A reliable indicator of the site-specific contaminants (i.e., specific conductance). Using these criteria

  3. Asteroid 2015 DB216: a recurring co-orbital companion to Uranus

    Science.gov (United States)

    de la Fuente Marcos, C.; de la Fuente Marcos, R.

    2015-10-01

    Minor bodies trapped in 1:1 co-orbital resonances with a host planet could be relevant to explain the origin of captured satellites. Among the giant planets, Uranus has one of the smallest known populations of co-orbitals, three objects, and all of them are short-lived. Asteroid 2015 DB216 has an orbital period that matches well that of Uranus, and here we investigate its dynamical state. Direct N-body calculations are used to assess the current status of this object, reconstruct its immediate dynamical past, and explore its future orbital evolution. A covariance matrix-based Monte Carlo scheme is presented and applied to study its short-term stability. We find that 2015 DB216 is trapped in a temporary co-orbital resonance with Uranus, the fourth known minor body to do so. A detailed analysis of its dynamical evolution shows that it is an unstable but recurring co-orbital companion to Uranus. It currently follows an asymmetric horseshoe trajectory that will last for at least 10 kyr, but it may remain inside Uranus' co-orbital zone for millions of years. As in the case of other transient Uranian co-orbitals, complex multibody ephemeral mean motion resonances trigger the switching between the various resonant co-orbital states. The new Uranian co-orbital exhibits a secular behaviour markedly different from that of the other known Uranian co-orbitals because of its higher inclination, nearly 38°. Given its rather unusual discovery circumstances, the presence of 2015 DB216 hints at the existence of a relatively large population of objects moving in similar orbits.

  4. Asteroid 2015 DB216: a recurring co-orbital companion to Uranus

    OpenAIRE

    Marcos, C. de la Fuente; Marcos, R. de la Fuente

    2015-01-01

    Minor bodies trapped in 1:1 co-orbital resonances with a host planet could be relevant to explain the origin of captured satellites. Among the giant planets, Uranus has one of the smallest known populations of co-orbitals, three objects, and all of them are short-lived. Asteroid 2015 DB216 has an orbital period that matches well that of Uranus, and here we investigate its dynamical state. Direct N-body calculations are used to assess the current status of this object, reconstruct its immediat...

  5. Summary and analysis of 216 GHz polarimetric measurements of in-situ rain

    Science.gov (United States)

    Hedden, Abigail S.; Wikner, David A.; Bradley, Russell W.

    2015-05-01

    The Army Research Laboratory (ARL) has developed a polarimetric frequency-modulated continuous-wave (FMCW) instrumentation radar that has been used to study the polarization and backscatter properties of in-situ rain in the 220 GHz atmospheric window. A summary of the preliminary measurements is presented in this work including an analysis of the co-polarization backscatter and attenuation characteristics measured at 216 GHz. A marginal detection of the copolarization backscatter signature of rain was made during a series of fast-moving, heavy downpour thunderstorm events. A detection limit of -40±3 dB[m2/m3] was found for the VV-polarization cross section per unit volume for rain rates up to 150 mm/hr. Co-polarization (VV- and HH-polarization) attenuation characteristics measured at high rain rates (< 20 mm/hr) were well described by a Joss thunderstorm drop distribution in the high frequency limit, where drop size is much greater than the observation wavelength. Observations at 216 GHz suggest attenuation levels of 8-10 dB/km at rain rates above 20 mm/hr, strengthening previous evidence that attenuation through rain is independent of frequency under high rain rate conditions. Attenuation measurements at lower rain rates (< 20 mm/hr) were qualitatively consistent with both Laws and Parsons and Joss thunderstorm distributions.

  6. Detection of Star Formation in the Unusually Cold Giant Molecular Cloud G216

    CERN Document Server

    Megeath, S T; Young, E; Allen, T; Pipher, J L; Wilson, T L

    2009-01-01

    The giant molecular cloud G216-2.5, also known as Maddalena's cloud or the Maddalena-Thaddeus cloud, is distinguished by an unusual combination of high gas mass (1-6 x 10^5) solar masses, low kinetic temperatures (10 K), and the lack of bright far infrared emission. Although star formation has been detected in neighboring satellite clouds, little evidence for star formation has been found in the main body of this cloud. Using a combination of mid-infrared observations with the IRAC and MIPS instruments onboard the Spitzer space telescope, and near-IR images taken with the Flamingos camera on the KPNO 2.1-meter, we identify a population of 41 young stars with disks and 33 protostars in the center of the cloud. Most of the young stellar objects are coincident with a filamentary structure of dense gas detected in CS (2-1). These observations show that the main body of G216 is actively forming stars, although at a low stellar density comparable to that found in the Taurus cloud.

  7. The Xinglong 2.16-m Telescope: Current Instruments and Scientific Projects

    CERN Document Server

    Fan, Zhou; Jiang, Xiaojun; Wu, Hong; Li, Hongbin; Huang, Yang; Xu, Dawei; Hu, Zhongwen; Zhu, Yinan; Wang, Jianfeng; Komossa, Stefanie; Zhang, Xiaoming

    2016-01-01

    The Xinglong 2.16-m reflector is the first 2-meter class astronomical telescope in China. It was jointly designed and built by the Nanjing Astronomical Instruments Factory (NAIF), Beijing Astronomical Observatory (now National Astronomical Observatories, Chinese Academy of Sciences, NAOC) and Institute of Automation, Chinese Academy of Sciences in 1989. It is Ritchey-Chr\\'{e}tien (R-C) reflector on an English equatorial mount and the effective aperture is 2.16 meters. It had been the largest optical telescope in China for $\\sim18$ years until the Guoshoujing Telescope (also called Large Sky Area Multi-Object Fiber Spectroscopic Telescope, LAMOST) and the Lijiang 2.4-m telescope were built. At present, there are three main instruments on the Cassegrain focus available: the Beijing Faint Object Spectrograph and Camera (BFOSC) for direct imaging and low resolution ($R\\sim500-2000$) spectroscopy, the spectrograph made by Optomechanics Research Inc. (OMR) for low resolution spectroscopy (the spectral resolutions a...

  8. Hirschsprung′s disease: Role of rectal suction biopsy - data on 216 specimens

    Directory of Open Access Journals (Sweden)

    Rahman Zillur

    2010-01-01

    Full Text Available Background: The diagnosis of Hirschsprung′s disease (HD is dependent on the histological study of rectal ganglion cells, and an open rectal biopsy was the mainstay that required general anaesthesia (GA and carried risk of postoperative rectal bleeding. Suction rectal biopsy later gained wide acceptance and became the choice as there is no requirement of GA and virtual absence of any complications. Materials and Methods: A retrospective review of the histological findings of 216 rectal suction biopsies studied from 2005 to 2009. Results: There were 143 male and 73 female children. 196 (90.7% children were within 1 year of age. Among 216 rectal suction biopsies 181 (83.80% were aganglionic, 27 (12.5% were ganglionic and 8 (3.7% were inadequate. Majority of patients were of less than 1 year of age (94.47%. Conclusions : The rectal suction biopsy is a bed side procedure, safe, cheap and time saving. There is high degree of accuracy, simplicity and absence of complications.

  9. Asteroid 2015 DB216: a recurring co-orbital companion to Uranus

    CERN Document Server

    Marcos, C de la Fuente

    2015-01-01

    Minor bodies trapped in 1:1 co-orbital resonances with a host planet could be relevant to explain the origin of captured satellites. Among the giant planets, Uranus has one of the smallest known populations of co-orbitals, three objects, and all of them are short-lived. Asteroid 2015 DB216 has an orbital period that matches well that of Uranus, and here we investigate its dynamical state. Direct N-body calculations are used to assess the current status of this object, reconstruct its immediate dynamical past, and explore its future orbital evolution. A covariance matrix-based Monte Carlo scheme is presented and applied to study its short-term stability. We find that 2015 DB216 is trapped in a temporary co-orbital resonance with Uranus, the fourth known minor body to do so. A detailed analysis of its dynamical evolution shows that it is an unstable but recurring co-orbital companion to Uranus. It currently follows an asymmetric horseshoe trajectory that will last for at least 10 kyr, but it may remain inside U...

  10. The Xinglong 2.16-m Telescope: Current Instruments and Scientific Projects

    Science.gov (United States)

    Fan, Zhou; Wang, Huijuan; Jiang, Xiaojun; Wu, Hong; Li, Hongbin; Huang, Yang; Xu, Dawei; Hu, Zhongwen; Zhu, Yinan; Wang, Jianfeng; Komossa, Stefanie; Zhang, Xiaoming

    2016-11-01

    The Xinglong 2.16-m reflector is the first 2-m class astronomical telescope in China. It was jointly designed and built by the Nanjing Astronomical Instruments Factory (NAIF), Beijing Astronomical Observatory (now National Astronomical Observatories, Chinese Academy of Sciences, NAOC), and Institute of Automation, Chinese Academy of Sciences in 1989. It is a Ritchey-Chrétien (R-C) reflector on an English equatorial mount and the effective aperture is 2.16 m. It had been the largest optical telescope in China for ∼18 years until the Guoshoujing Telescope (also called Large Sky Area Multi-Object Fiber Spectroscopic Telescope, LAMOST) and the Lijiang 2.4-m telescope were built. At present, there are three main instruments on the Cassegrain focus available: the Beijing Faint Object Spectrograph and Camera (BFOSC) for direct imaging and low-resolution (R ∼ 500–2000) spectroscopy, the spectrograph made by Optomechanics Research Inc. (OMR) for low-resolution spectroscopy (the spectral resolutions are similar to those of BFOSC) and the fiber-fed High Resolution Spectrograph (HRS; R ∼ 30,000–65,000). The telescope is widely open to astronomers all over China as well as international astronomical observers. Each year there are more than 40 ongoing observing projects, including 6–8 key projects. Recently, some new techniques and instruments (e.g., astro-frequency comb calibration system, polarimeter, and adaptive optics) have been or will be tested on the telescope to extend its observing abilities.

  11. 20 CFR 652.216 - May the One-Stop operator provide guidance to State merit-staff employees in accordance with the...

    Science.gov (United States)

    2010-04-01

    ... State merit-staff employees in accordance with the Act? 652.216 Section 652.216 Employees' Benefits... operator provide guidance to State merit-staff employees in accordance with the Act? Yes, the One-Stop... accountability of State merit-staff employees funded under the Act, remain under the authority of the...

  12. Separation and Biochemical Properties of Protein Mp-21.6 from Momordica charantia%苦瓜Mp-21.6蛋白的分离及生化特性

    Institute of Scientific and Technical Information of China (English)

    蔡马; 于群; 朱新产

    2011-01-01

    为研究苦瓜蛋白的有效分离技术与抑菌活性,本实验采用(NH4)2SO4分级分离油苦瓜(Momordica charantia L.)蛋白质,将SephadexG-100凝胶柱在DEAE-52阴离子交换柱色谱上作站上串联,分步聚集纯化出苦瓜蛋白Mp-21.6.SDS-PAGE凝胶电泳显示单一蛋白条带;经生化分析鉴定,Mp-21.6 (Momordica protein of 21.6 kD)蛋白的分子量为21.6 kD,等电点pI=9.6;双向还原SDS-PAGE确定苦瓜蛋白Mp-21.6仅存在链内二硫健;Aacomplement软件的基于氨基酸组成比较发现,Mp-21.6类似于RNMC_MOMCH [Ribonuclease MC (RNase MC,EC=3.1.27.1)].抑菌试验显示Mp-21.6对大肠杆菌(Escherichia coli)、金黄色葡萄球菌(Staphylococcus aure us)、沙门氏菌(Salmonellab sp)、枯草芽胞杆菌(Bacillus sabtilis)、啤酒酵母(Saccharomyces cerevisiae)和黄曲霉(Aspergillus flavus)产生明显的抑菌活性,其最小抑菌浓度(MIC)远低于苯甲酸钠.随着苦瓜蛋白的逐级分离纯化,其清除羟自由基和总抗氧化能力均有上升的趋势.研究结果提示,苦瓜Mp-21.6蛋白具有广谱抗菌活性及显著的抗氧化能力,利用区隔性分离方式,分级提纯苦瓜的生物活性蛋白,将能开发出有发展潜力的新型抗菌药物.%In order to investigate technology of isolation and purification, and antimicrobial activity of pulp protein, in this paper, protein Mp-21.6 was isolated and purified from the pulp (Momordica charantia L.) by ammonium sulphate fractionation chromatographies on Sephadex G -100 and DEAE-52. And the protein was analyzed via SDS-PAGE and biochemical determination. The results showed that Mp-21.6 was homogeneous single band with molecular weight of 21.6 kD and pi 9.6. Mp-21.6 protein had intrachain disulfide bond by reductive two-dimensional electrophoresis. And Mp-21.6 was similar to RNMCMOMCH [Ribonuclease MC (Rnase MC, EC=3.1.27.1)] compared with amino acids by Aacomplement software. Antimicrobial activities of the protein were detected by

  13. Fission characteristics of 216Ra formed in heavy-ion induced reactions

    Indian Academy of Sciences (India)

    Hadi Eslamizadeh

    2013-11-01

    A Kramers-modified statistical model is used to calculate the cross-section of the evaporation residue, fission cross-section, average pre-fission multiplicities of protons and -particles for 216Ra formed in 19F + 197Au reactions and results are compared with the experimental data. To calculate these quantities, the effects of temperature and spin K about the symmetry axis have been considered in the calculations of the potential energy surfaces and the fission widths. It is shown that the results of the calculations using values of the temperature coefficient of the effective potential = 0.008 ± 0.003 MeV−2 and scaling factor of the fission-barrier height $r_{s} = 1.004 ± 0.002$ are in good agreement with the experimental data.

  14. Energetic sub-2-cycle laser with 216  W average power.

    Science.gov (United States)

    Hädrich, Steffen; Kienel, Marco; Müller, Michael; Klenke, Arno; Rothhardt, Jan; Klas, Robert; Gottschall, Thomas; Eidam, Tino; Drozdy, András; Jójárt, Péter; Várallyay, Zoltán; Cormier, Eric; Osvay, Károly; Tünnermann, Andreas; Limpert, Jens

    2016-09-15

    Few-cycle lasers are essential for many research areas such as attosecond physics that promise to address fundamental questions in science and technology. Therefore, further advancements are connected to significant progress in the underlying laser technology. Here, two-stage nonlinear compression of a 660 W femtosecond fiber laser system is utilized to achieve unprecedented average power levels of energetic ultrashort or even few-cycle laser pulses. In a first compression step, 408 W, 320 μJ, 30 fs pulses are achieved, which can be further compressed to 216 W, 170 μJ, 6.3 fs pulses in a second compression stage. To the best of our knowledge, this is the highest average power few-cycle laser system presented so far. It is expected to significantly advance the fields of high harmonic generation and attosecond science. PMID:27628390

  15. Ground water impact assessment report for the 216-B-3 Pond system

    International Nuclear Information System (INIS)

    Ground water impact assessments were required for a number of liquid effluent receiving sites according to the Hanford Federal Facility Agreement and Consent Order Milestones M-17-00A and M-17-00B, as agreed upon by the US Department of Energy. This report is one of the last three assessments required and addresses the impact of continued discharge of uncontaminated wastewater to the 216-B-3C expansion lobe of the B Pond system in the 200 East Area until June 1997. Evaluation of past and projected effluent volumes and composition, geohydrology of the receiving site, and contaminant plume distribution patterns, combined with ground water modeling, were used to assess both changes in ground water flow regime and contaminant-related impacts

  16. Energetic sub-2-cycle laser with 216  W average power.

    Science.gov (United States)

    Hädrich, Steffen; Kienel, Marco; Müller, Michael; Klenke, Arno; Rothhardt, Jan; Klas, Robert; Gottschall, Thomas; Eidam, Tino; Drozdy, András; Jójárt, Péter; Várallyay, Zoltán; Cormier, Eric; Osvay, Károly; Tünnermann, Andreas; Limpert, Jens

    2016-09-15

    Few-cycle lasers are essential for many research areas such as attosecond physics that promise to address fundamental questions in science and technology. Therefore, further advancements are connected to significant progress in the underlying laser technology. Here, two-stage nonlinear compression of a 660 W femtosecond fiber laser system is utilized to achieve unprecedented average power levels of energetic ultrashort or even few-cycle laser pulses. In a first compression step, 408 W, 320 μJ, 30 fs pulses are achieved, which can be further compressed to 216 W, 170 μJ, 6.3 fs pulses in a second compression stage. To the best of our knowledge, this is the highest average power few-cycle laser system presented so far. It is expected to significantly advance the fields of high harmonic generation and attosecond science.

  17. Ground water impact assessment report for the 216-B-3 Pond system

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, V.G.; Law, A.G.; Reidel, S.P.; Evelo, S.D.; Barnett, D.B.; Sweeney, M.D.

    1995-01-01

    Ground water impact assessments were required for a number of liquid effluent receiving sites according to the Hanford Federal Facility Agreement and Consent Order Milestones M-17-00A and M-17-00B, as agreed upon by the US Department of Energy. This report is one of the last three assessments required and addresses the impact of continued discharge of uncontaminated wastewater to the 216-B-3C expansion lobe of the B Pond system in the 200 East Area until June 1997. Evaluation of past and projected effluent volumes and composition, geohydrology of the receiving site, and contaminant plume distribution patterns, combined with ground water modeling, were used to assess both changes in ground water flow regime and contaminant-related impacts.

  18. Groundwater monitoring plan for the Hanford Site 216-B-3 pond RCRA facility

    Energy Technology Data Exchange (ETDEWEB)

    Barnett, D.B.; Chou, C.J.

    1998-06-01

    The 216-B-3 pond system was a series of ponds for disposal of liquid effluent from past Hanford production facilities. In operation since 1945, the B Pond system has been a RCRA facility since 1986, with Resource Conservation and Recovery Act (RCRA) interim-status groundwater monitoring in place since 1988. In 1994, discharges were diverted from the main pond, where the greatest potential for contamination was thought to reside, to the 3C expansion pond. In 1997, all discharges to the pond system were discontinued. In 1990, the B Pond system was elevated from detection groundwater monitoring to an assessment-level status because total organic halogens and total organic carbon were found to exceed critical means in two wells. Subsequent groundwater quality assessment failed to find any specific hazardous waste contaminant that could have accounted for the exceedances, which were largely isolated in occurrence. Thus, it was recommended that the facility be returned to detection-level monitoring.

  19. 50 CFR 216.92 - Dolphin-safe requirements for tuna harvested in the ETP by large purse seine vessels.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Dolphin-safe requirements for tuna... MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS Dolphin Safe Tuna Labeling § 216.92 Dolphin-safe requirements for tuna harvested in the ETP by large purse seine vessels. (a)...

  20. 30 CFR 77.216-2 - Water, sediment, or slurry impoundments and impounding structures; minimum plan requirements...

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Water, sediment, or slurry impoundments and... COAL MINES Surface Installations § 77.216-2 Water, sediment, or slurry impoundments and impounding... under design storm conditions, sediment or slurry level, water level and other information pertinent...

  1. Treatability Test Report: Characterization of Vadose Zone Carbon Tetrachloride Source Strength Using Tomographic Methods at the 216-Z-9 Site

    Energy Technology Data Exchange (ETDEWEB)

    Truex, Michael J.; Carroll, Kenneth C.; Rohay, Virginia J.; Mackley, Rob D.; Parker, Kyle R.

    2012-09-28

    A treatability test was conducted in 2011 at the 216-Z-9 Trench to evaluate methods for collecting characterization information that supports refined assessment of SVE performance goals based on impact to groundwater. The characterization information can also provide input to operational strategies for continued SVE operation and decisions regarding closure of the SVE system or transition to other remedies, if necessary.

  2. Clinicopathological features and prognostic factors of 216 cases with primary gastrointestinal tract non-Hodgkin’s lymphoma

    Institute of Scientific and Technical Information of China (English)

    尹文娟

    2013-01-01

    Objective To investigate the clinicopathological features of primary gastrointestinal non-Hodgkin’s lymphomas (PGI-NHL) and their prognostic values.Methods The clinical and pathological data of 216 patients diagnosed as PGI-NHL from Zhejiang Cancer Hospital were

  3. 20 CFR 216.68 - Disability period for widow(er), surviving divorced spouse, or remarried widow(er).

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Disability period for widow(er), surviving... BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT ELIGIBILITY FOR AN ANNUITY Widow(er), Surviving Divorced Spouse, and Remarried Widow(er) Annuities § 216.68 Disability period for widow(er),...

  4. NCDC216: A New Multistate Group for Water Management and Quality for Ornamental Crop Production and Health

    Science.gov (United States)

    We have established a USDA multistate development committee (NCDC216) to create a project focused on water management and quality for ornamental crop production and health. The nursery and greenhouse industry ranks 5th (>$14.6 billion) among all US agriculture commodities and within the top 5 commod...

  5. Constraints on the size of Asteroid (216) Kleopatra using stress analysis

    Science.gov (United States)

    Hirabayashi, M.; Scheeres, D. J.

    2013-12-01

    We investigate the stable size of Asteroid (216) Kleopatra by considering structural constraints on this body. Comprehensive radar observations (Ostro et al. 2000, Science) were used to estimate a shape model for this asteroid. Their estimation revealed that the shape looks like a dog-bone, the mean radius is 54.3 km (with uncertainty as large as 25%), and the surface seems similar to lunar surface regolith. However, 10 years later, Descamps et al. (2011, Icarus) performed near-infrared adaptive optics (AO) imaging with the W.M. Keck II telescope and found that although the shape may be consistent with their observation result, their size appeared to be larger than the Ostro size (by a factor of about 1.24). Our motivation in this study is to investigate structural stability constraints on the size of this asteroid. Across the stated range of uncertainty we find significant differences in the necessary angle of friction and cohesion for the body to avoid plastic deformation. We use the following physical parameters as fixed: a mass of 4.64e18 kg (Descamps et al. 2011, Icarus), a rotation period of 5.385 hr (Magnusson 1990, Icarus), and the Ostro et al. shape. We use the Drucker-Prager criterion to describe the rheology of the asteroid's material. Furthermore, we determine the friction angle from the fact that the surface of this asteroid is similar to lunar surface regolith, whose porosity ranges from 33% to 55%. According to Scott (1963), a soil with porosity of 44% (the mean value of the lunar surface porosity) has a friction angle of 32 degrees (which we use as our nominal value). Since the interior structure is unknown, we assume that the body is homogeneous. We first analyze the stable size by using the upper bound theorem from limit analysis on the assumption that this asteroid's materials are cohesionless. Based on this theorem, for any static surface traction and body force, the yield due to a smooth and convex yield envelope associated with the volume

  6. Minimally invasive percutaneous nephrolithotomy for the treatment of upper ureteral calculi:A Report of 216 cases%微创经皮肾镜取石术治疗输尿管上段结石216

    Institute of Scientific and Technical Information of China (English)

    马宇杰; 黄志远; 杨建设; 张毅; 王威; 何育霖

    2010-01-01

    目的 探讨微创经皮肾镜取石术(minimally invasive percutaneous nephrolithotomy,MPCNL)治疗输尿管上段结石的疗效.方法 2004年7月至2010年1月对采用MPCNL治疗的216例输尿管上段结石患者的临床资料进行回顾性分析.结果 216例均为一期取石,结石清除率98.5%,平均手术时间70 min,术中平均估计出血量50 ml,无严重并发症发生.结论 MPCNL治疗输尿管上段结石,结石清除率高,创伤小,出血少,恢复快,安全有效.

  7. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2013. Scientific Opinion on Flavouring Group Evaluation 216, Revision 1 (FGE.216Rev1). Consideration of genotoxic potential for α,β-unsaturated 2-Phenyl -2-Alkenals from Subgroup 3.3 of FGE.19

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Binderup, Mona-Lise; Lund, Pia;

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate the genotoxic potential of five flavouring substances from subgroup 3.3 of FGE.19. In the Flavouring Group Evaluation 216 (FGE.216) additional genotoxicity...

  8. Risk factors associated with typhoid fever in children aged 2-16 years in Karachi, Pakistan.

    Science.gov (United States)

    Khan, M I; Ochiai, R L; Soofi, S B; Von-Seidlein, L; Khan, M J; Sahito, S M; Habib, M A; Puri, M K; Park, J K; You, Y A; Ali, M; Nizami, S Q; Acosta, C J; Bradley-Sack, R; Clemens, J D; Bhutta, Z A

    2012-04-01

    We analysed the data from the control group in a typhoid vaccine trial in Karachi to assess the differences in individual-, household- and cluster-level characteristics for developing typhoid fever. The annual incidence of typhoid in children aged 2-16 years in the control arm of the vaccine trial was 151/100 000 population. After adjustment, the risk of typhoid was lower with increasing age [risk ratio (RR) 0·89, 95% confidence interval (CI) 0·83-0·95], was higher with an increase in population density (RR 1·13, 95% CI 1·05-1·21) and was lower in the households using a safe drinking-water source (RR 0·63, 95% CI 0·41-0·99). Typhoid fever affects younger children living in areas of high population density and lack of access to safe water in Pakistan. A combination of environmental and biological interventions is required to prevent the continued epidemiological and economic impact of typhoid fever in high-risk areas of Pakistan.

  9. ASASSN-15oi: A Rapidly Evolving, Luminous Tidal Disruption Event at 216 Mpc

    CERN Document Server

    Holoien, T W -S; Prieto, J L; Grupe, D; Chen, Ping; Godoy-Rivera, D; Stanek, K Z; Shappee, B J; Dong, Subo; Brown, J S; Basu, U; Beacom, J F; Bersier, D; Brimacombe, J; Carlson, E K; Falco, E; Johnston, E; Madore, B F; Pojmanski, G; Seibert, M

    2016-01-01

    We present ground-based and Swift photometric and spectroscopic observations of the tidal disruption event (TDE) ASASSN-15oi, discovered at the center of 2MASX J20390918-3045201 ($d\\simeq216$ Mpc) by the All-Sky Automated Survey for SuperNovae (ASAS-SN). The source peaked at a bolometric luminosity of $L\\simeq1.9\\times10^{44}$ ergs s$^{-1}$ and radiated a total energy of $E\\simeq5.0\\times10^{50}$ ergs over the $\\sim3.5$ months of observations. The early optical/UV emission of the source can be fit by a blackbody with temperature increasing from $T\\sim2\\times10^4$ K to $T\\sim6\\times10^4$ K while the luminosity declines from $L\\simeq1.9\\times10^{44}$ ergs s$^{-1}$ to $L\\simeq2.8\\times10^{43}$ ergs s$^{-1}$, requiring the photosphere to be shrinking rapidly. The optical/UV luminosity decline is broadly consistent with an exponential decline, $L\\propto e^{-t/t_0}$, with $t_0\\simeq35$ days. ASASSN-15oi also exhibits roughly constant soft X-ray emission that is significantly weaker than the optical/UV emission. Spe...

  10. Three Alginate Lyases from Marine Bacterium Pseudomonas fluorescens HZJ216: Purification and Characterization

    Energy Technology Data Exchange (ETDEWEB)

    Liyan, Li [Ocean University of China, Qingdao, PRC; Jiang, Xiaolu [Ocean University of China, Qingdao, PRC; Wang, Peng [Ocean University of China, Qingdao, PRC; Guan, Huashi [Ocean University of China, Qingdao, PRC; Guo, Hong [ORNL

    2010-01-01

    Three alginate lyases (A, B, and C) from an alginate-degrading marine bacterium strain HZJ216 isolated from brown seaweed in the Yellow Sea of China and identified preliminarily as Pseudomonas fluorescens are purified, and their biochemical properties are described. Molecular masses of the three enzymes are determined by SDS-PAGE to be 60.25, 36, and 23 kDa with isoelectric points of 4, 4.36, and 4.59, respectively. Investigations of these enzymes at different pH and temperatures show that they are most active at pH 7.0 and 35 C. Alginate lyases A and B are stable in the pH range of 5.0 9.0, while alginate lyase C is stable in the pH range of 5.0 7.0. Among the metal ions tested, additions of Na+, K+, and Mg2+ ions can enhance the enzyme activities while Fe2+, Fe3+, Ba2+, and Zn2+ ions show inhibitory effects. The substrate specificity results demonstrate that alginate lyase C has the specificity for G block while alginate lyases A and B have the activities for both M and G blocks. It is the first report about extracellular alginate lyases with high alginate-degrading activity from P. fluorescens.

  11. 4$\\pi$ detector for study of Zeno effect using 220Rn -> 216Po alpha->alpha correlated chains

    CERN Document Server

    Nadderd, L; Subotic, K; Polyakov, A N; Lobanov, Y V; Rykhlyuk, A V

    2015-01-01

    First test of the 4pi detector for study of exponential law of radioactive decay and possibility of observation of Zeno effect [1-3], measuring the mean life of 216Po is presented. This detector consists of two surface-barrier n-Si(Au) detectors placed in the close contact ( 4T1/2. Both, the data acquisition system and the vacuum chamber design are presented in brief.

  12. The predicted impacts to the groundwater and Columbia River from ammoniated water discharges to the 216-A-36B crib

    International Nuclear Information System (INIS)

    Impact from past and potential future discharges of ammoniated water to the 216-A-36B crib have on groundwater and river concentrations of hazardous chemical constitutents are studied. Until August 1987, the 216-A-36B crib, located in the 200-East Area of the Hanford Site, accepted ammoniated water discharges. Although this study addresses known hazardous chemical constituents associated with such discharges, the primary concern is the discharge of NH4OH because of its microbiological conversion to NO2/sup /minus// and NO3/sup /minus//. As a result of fuel decladding operations, material balance calculations indicate that NH4OH has been discharged to the 216-A-36B crib in amounts that exceed reportable quantities under the Comprehensive Environmental Response, Compensation and Liability Act of 1980. Although flow to the crib is relatively constant, the estimated NH4OH discharge varies from negligible to a maximum of 10,000 g-molesh. Because these discharges are intermittent, the concentration delivered to the groundwater is a function of soil sorption, microbiological conversion rates of NH4+ to NO2/sup /minus// and NO3/sup /minus//, and groundwater dispersion. This report provides results based on the assumptions of maximum, nominal, and discountinued NH4OH discharges to the crib. Consequently, the results show maximum and realistic estimates of NH4+, NO2/sup /minus// and NO3/sup /minus// concentrations in the groundwater

  13. ASASSN-15oi: A Rapidly Evolving, Luminous Tidal Disruption Event at 216 Mpc

    Science.gov (United States)

    Holoien, T. W.-S.; Kochanek, C. S.; Prieto, J. L.; Grupe, D.; Chen, Ping; Godoy-Rivera, D.; Stanek, K. Z.; Shappee, B. J.; Dong, Subo; Brown, J. S.; Basu, U.; Beacom, J. F.; Bersier, D.; Brimacombe, J.; Carlson, E. K.; Falco, E.; Johnston, E.; Madore, B. F.; Pojmanski, G.; Seibert, M.

    2016-09-01

    We present ground-based and Swift photometric and spectroscopic observations of the tidal disruption event (TDE) ASASSN-15oi, discovered at the center of 2MASX J20390918-3045201 (d ≃ 216 Mpc) by the All-Sky Automated Survey for SuperNovae (ASAS-SN). The source peaked at a bolometric luminosity of L ≃ 1.3 × 1044 ergs s-1 and radiated a total energy of E ≃ 6.6 × 1050 ergs over the first ˜3.5 months of observations. The early optical/UV emission of the source can be fit by a blackbody with temperature increasing from T ˜ 2 × 104 K to T ˜ 4 × 104 K while the luminosity declines from L ≃ 1.3 × 1044 ergs s-1 to L ≃ 2.3 × 1043 ergs s-1, requiring the photosphere to be shrinking rapidly. The optical/UV luminosity decline during this period is most consistent with an exponential decline, L∝ e^{-(t-t_0)/τ}, with τ ≃ 46.5 days for t0 ≃ 57241.6 (MJD), while a power-law decline of L∝(t - t0)-α with t0 ≃ 57212.3 and α = 1.62 provides a moderately worse fit. ASASSN-15oi also exhibits roughly constant soft X-ray emission that is significantly weaker than the optical/UV emission. Spectra of the source show broad helium emission lines and strong blue continuum emission in early epochs, although these features fade rapidly and are not present ˜3 months after discovery. The early spectroscopic features and color evolution of ASASSN-15oi are consistent with a TDE, but the rapid spectral evolution is unique among optically-selected TDEs.

  14. Energetic constraints on a rapid gamma-ray flare in PKS 1222+216

    Science.gov (United States)

    Nalewajko, Krzysztof; Begelman, Mitchell C.; Cerutti, Benoît.; Uzdensky, Dmitri A.; Sikora, Marek

    2012-10-01

    We study theoretical implications of a rapid very high energy (VHE) flare detected by MAGIC in the flat spectrum radio quasar PKS 1222+216. The minimum distance from the jet origin at which this flare could be produced is 0.5 pc. A moderate Doppler factor of the VHE source, D VHE ˜20, is allowed by all opacity constraints. The concurrent high-energy (HE) emission observed by Fermi provides estimates of the total jet power and the jet magnetic field strength. Energetic constraints for the VHE flare are extremely tight: for an isotropic particle distribution, they require a huge comoving energy density in the emitting region and a very efficient radiative process. We disfavour hadronic processes due to their low radiative efficiency, as well as the synchrotron scenario recently proposed for the case of HE flares in the Crab nebula, since the parameters needed to overcome the radiative losses are quite extreme. The VHE emission can be explained by the synchrotron self-Compton mechanism for D VHE ˜20 or by the external radiation Compton mechanism involving the infrared radiation of the dusty torus for D VHE ˜50. After discussing several alternative scenarios, we propose that the extreme energy density constraint can be satisfied when the emission comes from highly anisotropic short-lived bunches of particles formed by the kinetic beaming mechanism in magnetic reconnection sites. By focusing the emitting particles into very narrow beams, this mechanism allows one to relax the causality constraint on the source size, decreasing the required energy density by four orders of magnitude.

  15. STUDY OF CLINICAL PROFILE AND OUTCOME OF 216 VICTIMS OF CHEST TRAUMA IN TERTIARY CARE CENTRE OF CENTRAL INDIA

    Directory of Open Access Journals (Sweden)

    Sanjay

    2015-11-01

    Full Text Available This observational study of 216 victims of chest injuries was carried out at Sri Aurobindo Medical College and Postgraduate Institute of Indore (India. The study was conducted from 1st January 2010 to 30th June 2014 in the Department of Surgery at Sri Aurobindo Medical College and Postgraduate Institute, Indore. Polytrauma is recognized as the leading cause of death and disability in first four decades of life and the third most common cause of death. Chest is the central portion of body which contains vital organs of utmost importance. As chest is a large and exposed portion, it is vulnerable to impact injuries which are frequently life threatening. This study was carried out to quantify the problem of chest injuries in the population at large with special reference to various clinical presentations and outcome of management at our centre. Although blunt and penetrating injuries both were included in the study, but blunt injuries were commoner (82.4%. Road traffic accident was responsible for 57.4% cases. A total of 120 patients out of 216 (55.5% were between 21 to 40 years of age. More than eighty percent victims were males. Musculoskeletal injuries (Long bone fractures etc., were the most common associated injuries. Twenty six (22.23% out of 216 died due to their injuries or complications. Twenty five percent were managed conservatively and were discharged in a satisfactory condition. One hundred and fifty nine needed thoracostomy, the commonest operative intervention. Overall outcome of chest injuries largely depends on magnitude and location of concomitant injuries. Prompt diagnosis of problem and immediate surgical intervention are the most important factors in the efficient management of chest injuries.

  16. A Retrospective Clinical Analysis of 216 Patients With Non-ST Segment Elevation Myocardial Infarction

    Institute of Scientific and Technical Information of China (English)

    Manish Pradhan; Shuxian Zhou; Juan Lei; Zesheng Liu

    2008-01-01

    Objectives To analyze the clinical characteristics of 216 patients with non-ST segment elevation myocardial infarc-tion (NSTEMI). Methods A retrospective analysis was used. Two hundred and sixteen NSTEMI patients were divid-ed into two groups: ①according to the age: age 178 μmol. L-1 group. Seven hundred and eighty six acute myocardial infarction (AMI) patients during the same period were divided into ST seg-ment elevation myocardial infarction (STEMI) group and NSTEMI group. Clinical characteristics of the patients in th e two groups were compared. Results ① The number of NSTEMI patients in age ≥65 years group is significantly grea-ter than that in age 178 μmol· L-1) and triple ves-sel disease. Fewer patients in this group received coronary artery angiography (CAG), percutaneous coronary interven-tion (PCI) and coronary artery bypass graft (CABG). More number of deaths in this group compared with the age 4 group is significantly greater than that in TIMI score 4 group comparing with TIMI score ≤4 group. ③ Obviously, more number of elderly patients, non-insulin dependant diabetes mellitus (NIDDM), patients with cardiac troponin T (CTnT) >3.0 ng · L-1 and deaths occurred in sCr > 178 μmol · L-1 group. @ STEMI and NSTEMI patients were compared in same time frame as follows: fewer NSTEMI patients and more elderly patients had no chest pain, NID-DM, hypertension, dyslipidemia, left main coronary artery (LMCA) disease while CTnT ≥3.0 ng· ml-1; fewer pa- tients with aneurysm (30 days) underwent CAG, PCI and CABG treatment. However, there were no significant differ-ences in smokers, patients with less than 50% stenosis in any vessel, 1 -3 vessel disease, acute left ventricle heart fail-ure, cardiogenic shock, serious arrhythmia and deaths. ⑤ The multivariate logistic regression analysis showed that death in NSTEMI was directly influenced by malignant arrhythmias with age ≥ 70 years. Conclusions Patients with NSTEMI were older, had more risk factors

  17. Influence of Neutron Shell Closure (Nc=126) on Prescission Particle Emission of Fissioning Systems 216,224Th

    Institute of Scientific and Technical Information of China (English)

    叶巍

    2003-01-01

    The effect of neutron shell closure Nc = 126 on the prescission-particle emission of 216Th and 224Th nuclei is investigated within the framework of an extensive Smoluchowski equation. It is found that there is a large difference in the prescission neutron multiplicity for the two Th nuclei, indicating a strong shell effect in neutron emission. Moreover, shell effects on particle emission are also investigated as functions of excitation energy,angular momentum and nuclear viscosity. The results show that with increasing excitation energy shell effects in prefission neutron evolve from continual strength to gradual weakness. Both high angular momenta and low viscosity weaken the shell effects on the particle emission.

  18. 中西结合治疗216例犬细小病毒病疗效观察%Clinical Observation of 216 Cases of Canine Parvovirus Disease by Treatment of Combining TCM and WM

    Institute of Scientific and Technical Information of China (English)

    宋洋铭; 叶得河

    2012-01-01

    通过临床症状、流行病学特点和犬细小病毒抗原试剂盒对疑似细小病毒感染的216例病犬进行确诊,并对确诊为细小病毒感染的部分病例进行抗体水平检测,以判断其预后,采用中西结合的综合措施治疗发病犬,治愈率达到70%,提出了有效的预防措施.%Author confirmed 216 cases of suspected canine parvovirus disease through the clinical signs, epidemiological characteristics and antigen rapid canine parvovirus test kit, to determine its prognosis, author detected antibody level of some cases of confirmed canine parvovirus disease, in addition, author achieved cure rate of 70% by comprehensive measures of treatment of combining TCM and WM, at last author propose effective prevention measures for canine parvovirus disease.

  19. Breast-conserving surgery and combined therapy for women breast cancer:a report of 216 cases%216例女性乳腺癌保乳手术及综合治疗的临床分析

    Institute of Scientific and Technical Information of China (English)

    Xianju Qin; Junxue Chen; Hongwei Zhang; Dafang Zhao; Hua Zhang; Wenjie Luo; Qian Huang; Shixian Lian; Hanxing Tong

    2007-01-01

    Objective:To explore the therapeutic effect and associated techniques of breast-conserving therapy on patients with clinical stage Ⅰand stage Ⅱ breasl cancer.Methods:216 female patients with breast cancer underwent breast-conserving therapy from December 1993 to October 2004.Their data were analyzed retrospectively.The breast-conserving therapy consisted of lumpectomy or quadrant removal of the breast,postoperative radiotherapy.chemotherapy and endocrine therapy.of them.209 patients underwent axillary lymph node dissection.Results:There were no operative complications.216patients were followed-up 3 to 147 months.the medial follow-up time was 78 months.The local recurrence rate was 1.85%.Two patients died and one of them was not related with breast cancer.Presence or absence of fibrosis,shape of breast,asymmetry,pigmentation and handle were taken into consideration for cosmetic evaluation by the patients and experienced breast surgeon.Breasts were scored cosmetically asexcellent and good in 199 patients.the rate of satisfactory was92.13%.Conclusion:Breast-conserving therapy for early breast cancer is a safe and effective therapy.It has less trauma and less complications and can also raise the quality of life in the patients.But we must obey the strict indications and reasonable techniques.

  20. 40 CFR 265 interim status indicator-evaluation ground-water monitoring plan for the 216-B-63 trench

    International Nuclear Information System (INIS)

    This document outlines a ground-water monitoring plan for the 216-B-63 trench located in the northeast corner of the 200-East Area on the Hanford Site in southeastern Washington State. It has been determined that hazardous materials (corrosives) were disposed of to the trench during past operations. Installation of an interim-status ground-water monitoring system is required to determine whether hazardous chemicals are leaching to the ground water from beneath the trench. This document summarizes the existing data that are available from near the 216-B-63 trench and presents a plan to determine the extent of ground-water contamination, if any, derived from the trench. The plan calls for the installation of four new monitoring wells located near the west end of the trench. These wells will be used to monitor ground-water levels and water quality immediately adjacent to the trench. Two existing RCRA monitoring wells, which are located near the trench and hydraulically upgradient of it, will be used as background wells. 46 refs., 15 figs., 12 tabs

  1. 宫腔内人工授精治疗不育症216例疗效观察

    Institute of Scientific and Technical Information of China (English)

    贾韶彤; 席向红; 刘鑫

    2006-01-01

    为观察男性不育症患者宫腔内人工授精(IUI)临床疗效,回顾性分析行IUI的216例患者的临床资料.患者4组:A组正常精液自然周期的卵泡成熟后采用IUI;B组正常精液采用促排卵后行IUI治疗;C组精液分析异常(精液不液化、少精症、弱精子症等)自然周期的卵泡成熟后采用IUI;D组免疫性不育(男性血清抗精了抗体阳性)自然周期的卵泡成熟后采用IUI.结果,216例男性不育患者进行245个周期的IUI,妊娠33例,妊娠率15.28%;正常精液促排卵进行IUI治疗的B组妊娠率最高,为19.04%.表明IUI适用于男方因素引起的不孕.

  2. Vadose Zone Contaminant Fate and Transport Analysis for the 216-B-26 Trench

    Energy Technology Data Exchange (ETDEWEB)

    Ward, Andy L.; Gee, Glendon W.; Zhang, Z. F.; Keller, Jason M.

    2004-10-14

    The BC Cribs and Trenches, part of the 200 TW 1 OU waste sites, received about 30 Mgal of scavenged tank waste, with possibly the largest inventory of 99Tc ever disposed to the soil at Hanford and site remediation is being accelerated. The purpose of this work was to develop a conceptual model for contaminant fate and transport at the 216-B-26 Trench site to support identification and development and evaluation of remediation alternatives. Large concentrations of 99Tc high above the water table implicated stratigraphy in the control of the downward migration. The current conceptual model accounts for small-scale stratigraphy; site-specific changes soil properties; tilted layers; and lateral spreading. It assumes the layers are spatially continuous causing water and solutes to move laterally across the boundary if conditions permit. Water influx at the surface is assumed to be steady. Model parameters were generated with pedotransfer functions; these were coupled high resolution neutron moisture logs that provided information on the underlying heterogeneity on a scale of 3 inches. Two approaches were used to evaluate the impact of remedial options on transport. In the first, a 1-D convolution solution to the convective-dispersive equation was used, assuming steady flow. This model was used to predict future movement of the existing plume using the mean and depth dependent moisture content. In the second approach, the STOMP model was used to first predict the current plume distribution followed by its future migration. Redistribution of the 99Tc plume was simulated for the no-action alternative and on-site capping. Hypothetical caps limiting recharge to 1.0, 0.5, and 0.1 mm yr-1 were considered and assumed not to degrade in the long term. Results show that arrival time of the MCLs, the peak arrival time, and the arrival time of the center of mass increased with decreasing recharge rate. The 1-D convolution model is easy to apply and can easily accommodate initial

  3. A program to compute three-dimensional subsonic unsteady aerodynamic characteristics using the doublet lattice method, L216 (DUBFLEX). Volume 2: Supplemental system design and maintenance document

    Science.gov (United States)

    Harrison, B. A.; Richard, M.

    1979-01-01

    The information necessary for execution of the digital computer program L216 on the CDC 6600 is described. L216 characteristics are based on the doublet lattice method. Arbitrary aerodynamic configurations may be represented with combinations of nonplanar lifting surfaces composed of finite constant pressure panel elements, and axially summetric slender bodies composed of constant pressure line elements. Program input consists of configuration geometry, aerodynamic parameters, and modal data; output includes element geometry, pressure difference distributions, integrated aerodynamic coefficients, stability derivatives, generalized aerodynamic forces, and aerodynamic influence coefficient matrices. Optionally, modal data may be input on magnetic field (tape or disk), and certain geometric and aerodynamic output may be saved for subsequent use.

  4. Carbon Tetrachloride Flow and Transport in the Subsurface of the 216-Z-18 Crib and 216-Z-1A Tile Field at the Hanford Site: Multifluid Flow Simulations and Conceptual Model Update

    Energy Technology Data Exchange (ETDEWEB)

    Oostrom, Mart; Rockhold, Mark L.; Thorne, Paul D.; Last, George V.; Truex, Michael J.

    2006-10-31

    Carbon tetrachloride (CT) was discharged to the 216-Z-9, Z-1A, and Z-18 waste sites that are included in the 200-PW-1 Operable Unit in Hanford 200 West Area. Fluor Hanford, Inc. is conducting a Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) remedial investigation/feasibility study (RI/FS) for the 200-PW-1 Operable Unit. As part of this overall effort, Pacific Northwest National Laboratory (PNNL) was contracted to improve the conceptual model of how CT is distributed in the Hanford 200 West Area subsurface through use of numerical flow and transport modeling. This work supports the U.S. Department of Energy's (DOE's) efforts to characterize the nature and distribution of CT in the 200 West Area and subsequently select an appropriate final remedy.

  5. 216例急性脑血管病的心电图特异性改变

    Institute of Scientific and Technical Information of China (English)

    刘素娟; 马建龙; 刘武杰

    2001-01-01

    @@近几年来,有关急性脑血管病(acute cerebro-vascular disease ACVD)心电图改变的报道逐渐增多,ACVD可引起多种心电图异常已受到国内外学者公认,但对其发生机制众说不一。近6年来,我们观察了216例数据完整的ACVD的心电图改变,现将其总结分析并对其发生机制及其治疗进行探讨。

  6. Carbon Tetrachloride Flow and Transport in the Subsurface of the 216-Z-9 Trench at the Hanford Site

    Science.gov (United States)

    Oostrom, M.; Rockhold, M.; Truex, M.; Thorne, P.; Last, G.; Rohay, V.

    2006-12-01

    Three-dimensional modeling was conducted with layered and heterogeneous models to enhance the conceptual model of CT distribution in the vertical and lateral direction beneath the 216-Z-9 trench and to investigate the effects of soil vapor extraction (SVE). This work supports the U.S. Department of Energy's (DOE's) efforts to characterize the nature and distribution of CT in the 200 West Area and subsequently select an appropriate final remedy. Simulations targeted migration of dense, nonaqueous phase liquid (DNAPL) consisting of CT and co-disposed organics in the subsurface beneath the 216-Z-9 trench as a function of the properties and distribution of subsurface sediments and of the properties and disposal history of the waste. Simulations of CT migration were conducted using the Subsurface Transport Over Multiple Phases (STOMP) simulator. Simulation results support a conceptual model for CT distribution where CT in the DNAPL phase is expected to have migrated primarily in a vertical direction below the disposal trench. Presence of small-scale heterogeneities tends to limit the extent of vertical migration of CT DNAPL due to enhanced retention of DNAPL compared to more homogeneous conditions, but migration is still predominantly in the vertical direction. Results also show that the Cold Creek units retain more CT DNAPL within the vadose zone than other hydrologic unit during SVE. A considerable amount of the disposed CT DNAPL may have partitioned to the vapor and subsequently water and sorbed phases. Presence of small-scale heterogeneities tends to increase the amount of volatilization. Any continued migration of CT from the vadose zone to the groundwater is likely through interaction of vapor phase CT with the groundwater and not through continued DNAPL migration. The results indicated that SVE appears to be an effective technology for vadose zone remediation, but additional effort is needed to improve simulation of the SVE process.

  7. One Day Every 216 Years, Three Days Each Decan. Rebirth Cycle of Pythagoras, Phoenix, Hazon Gabriel, and Christian Dogma of Resurrection Can Be Explained by the Metonic Cycle

    Science.gov (United States)

    Rothwangl, S.

    2009-08-01

    This article explains how the Metonic cycle is at the base of the period of 216 years Pythagoras believed in being reborn after that period. It shows how this period calendrically is related to other mythological worldviews such as the Phoenix myth, the Hebrean Hazon Gabriel, and the Christian dogma of resurrection on the third day.

  8. Regulation of UGT2B Expression and Activity by miR-216b-5p in Liver Cancer Cell Lines.

    Science.gov (United States)

    Dluzen, Douglas F; Sutliff, Aimee K; Chen, Gang; Watson, Christy J W; Ishmael, Faoud T; Lazarus, Philip

    2016-10-01

    The UDP-glucuronosyltransferase (UGT) 2B enzymes are important in the detoxification of a variety of endogenous and exogenous compounds, including many hormones, drugs, and carcinogens. Identifying novel mechanisms governing their expression is important in understanding patient-specific response to drugs and cancer risk factors. In silico prediction algorithm programs were used to screen for microRNAs (miRNAs) as potential regulators of UGT2B enzymes, with miR-216b-5p identified as a potential candidate. Luciferase data suggested the presence of a functional miR-216b-5p binding motif within the 3' untranslated regions of UGTs 2B7, 2B4, and 2B10. Overexpression of miR-216b-5p mimics significantly repressed UGT2B7 (P < 0.001) and UGT2B10 (P = 0.0018) mRNA levels in HuH-7 cells and UGT2B4 (P < 0.001) and UGT2B10 (P = 0.018) mRNA in Hep3B cells. UGT2B7 protein levels were repressed in both HuH-7 and Hep3B cells in the presence of increasing miR-216b-5p concentrations, corresponding with significant (P < 0.001 and P = 0.011, respectively) decreases in glucuronidation activity against the UGT2B7-specific substrate epirubicin. Inhibition of endogenous miR-216b-5p levels significantly increased UGT2B7 mRNA levels in HuH-7 (P = 0.021) and Hep3B (P = 0.0068) cells, and increased epirubicin glucuronidation by 85% (P = 0.057) and 50% (P = 0.012) for HuH-7 and Hep3B cells, respectively. UGT2B4 activity against codeine and UGT2B10 activity against nicotine were significantly decreased in both HuH-7 and Hep3B cells (P < 0.001 and P = 0.0048, and P = 0.017 and P = 0.043, respectively) after overexpression of miR-216b-5p mimic. This is the first evidence that miRNAs regulate UGT 2B7, 2B4, and 2B10 expression, and that miR-216b-5p regulation of UGT2B proteins may be important in regulating the metabolism of UGT2B substrates.

  9. The HIF-2α-MALAT1-miR-216b axis regulates multi-drug resistance of hepatocellular carcinoma cells via modulating autophagy.

    Science.gov (United States)

    Yuan, Peng; Cao, Weibin; Zang, Quanling; Li, Guixin; Guo, Xiangfei; Fan, Jianghe

    2016-09-23

    In this study, we firstly investigated the association among lncRNA MALAT1, HIF-1α and HIF-2α in hepatocellular carcinoma (HCC) cells. Then, we investigated the regulative effect of MALAT1 on multi-drug resistance (MDR) in HCC cells and the underlying mechanism. The results showed that MALAT1 was over two times higher in BEL-7402/5-FU cells than in BEL-7402 cells. It was HIF-2α, but not HIF-1α induced MALAT1 upregulation in HCC cells. Dual luciferase assay demonstrated that there were at least two binding sites of miR-26b in MALAT1. Therefore, we infer that there is a HIF-2α-MALAT1-miR-216b axis in HCC cells. Cell viability assay showed that both MALAT1 siRNA and miR-216b mimics reduced IC50 of 5-FU, ADR and MMC in BEL-7402/5-FU cells. MALAT1 siRNA and miR-216b mimics showed similar effect as 3-MA on reducing LC3-II levels, inhibiting p62 degradation and suppressing GFP-LC3 puncta formation in BEL-7402/5-FU cells. Flow cytometric analysis showed that 3-MA treatment, MALAT1 siRNA and miR-216b mimics all promoted 5-FU induced apoptosis in BEL-7402/5-FU cells. Therefore, this study firstly revealed that there is a HIF-2α-MALAT1-miR-216b axis regulating MDR of HCC cells via modulating autophagy. PMID:27524242

  10. Percutaneous Laser Disc Decompression for Lumbar Disc Retrospective Analysis: Report of 216 Cases%经皮激光减压术治疗腰椎间盘突出症216

    Institute of Scientific and Technical Information of China (English)

    赵继荣; 朱换平; 陈文

    2011-01-01

    Objective To observe the therapeutic effect of percutaneous laser disc decompression on lumbar disc herniation.Methods 216 cases of lumbar discherniation were treated by percutaneous laser disc decompression therapy, and were followed up for 1 week, three months, one year and three years respectirely to assess the efficacy.Results The efficient and excellent rates were 56.9% and 93.1%, 80.8% and 95.3%, 83.4% and 94.5%, 82.8% and 93.8%.7 days, 3 months, 1 year and 3 years after operation, respectively.The disease was in a recovery stage within the first year after operation and become stable then.Conclusions Percutaneous laser disc decompression in effective for treatment of disc herniation with less complications and its longterm effects is better the short-term effect.%目的 观察经皮激光减压术治疗腰椎间盘突出症的疗效.方法 对符合纳入标准的216例腰椎间盘突出症患者应用经皮激光间盘气化减压术治疗,分别于术后1周、3个月、1和3年进行随访,评定疗效.结果 有效率、优良率术后3d分别为56.9%、93.1%;术后3个月分别为80.8%、95.3%;术后1年分别为83.4%、94.5%;术后3年分别为82.8%、93.8%.术后1年内处于病情恢复阶段,1年后疗效稳定.结论 经皮激光气化减压术治疗椎间盘突出症疗效确切、并发症少,远期效果好于近期效果.

  11. A single infusion of MDCO-216 (ApoA-1 Milano/POPC) increases ABCA1-mediated cholesterol efflux and pre-beta 1 HDL in healthy volunteers and patients with stable coronary artery disease

    OpenAIRE

    Kallend, D.G.; Reijers, J.A.A.; Bellibas, S. E.; Bobillier, A.; Kempen, H. van; Burggraaf, J; Moerland, M.; Wijngaard, P.L.J.

    2015-01-01

    Aims Apolipoprotein A-1 (ApoA-1), based on epidemiology, is inversely associated with cardiovascular (CV) events. Human carriers of the ApoA-1 Milano variant have a reduced incidence of CV disease. Regression of atherosclerotic plaque burden was previously observed on intravascular ultrasound (IVUS) with ETC-216, a predecessor of MDCO-216. MDCO-216, a complex of dimeric ApoA-1 Milano and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, is being developed to reduce atherosclerotic plaque burd...

  12. Incubation of MDCO-216 (ApoA-IMilano/POPC) with Human Serum Potentiates ABCA1-Mediated Cholesterol Efflux Capacity, Generates New Prebeta-1 HDL, and Causes an Increase in HDL Size

    OpenAIRE

    Herman J. Kempen; Schranz, Dorota B.; Asztalos, Bela F.; James Otvos; Elias Jeyarajah; Denise Drazul-Schrader; Collins, Heidi L.; Adelman, Steven J.; Wijngaard, Peter L. J.

    2014-01-01

    MDCO-216 is a complex of dimeric ApoA-IMilano and palmitoyl oleoyl phosphatidylcholine (POPC), previously shown to reduce atherosclerotic plaque burden. Here we studied the effect of incubation of human plasma or serum with MDCO-216 on cholesterol efflux capacity from J774 cells, on prebeta-1 high density lipoprotein (prebeta-1 HDL) and on HDL size assessed by proton nuclear magnetic resonance (1H-NMR). MDCO-216 incubated in buffer containing 4% human serum albumin stimulated both ABCA1-media...

  13. A simulation study of the performance of the NASA (2,1,6) convolutional code on RFI/burst channels

    Science.gov (United States)

    Perez, Lance C.; Costello, Daniel J., Jr.

    1993-01-01

    In an earlier report, the LINKABIT Corporation studied the performance of the (2,1,6) convolutional code on the radio frequency interference (RFI)/burst channel using analytical methods. Using an R(sub 0) analysis, the report concluded that channel interleaving was essential to achieving reliable performance. In this report, Monte Carlo simulation techniques are used to study the performance of the convolutional code on the RFI/burst channel in more depth. The basic system model under consideration is shown. The convolutional code is the NASA standard code with generators g(exp 1) = 1+D(exp 2)+D(exp 3)+D(exp 5)+D(exp 6) and g(exp 2) = 1+D+D(exp 2)+D(exp 3)+D(exp 6) and d(sub free) = 10. The channel interleaver is of the convolutional or periodic type. The binary output of the channel interleaver is transmitted across the channel using binary phase shift keying (BPSK) modulation. The transmitted symbols are corrupted by an RFI/burst channel consisting of a combination of additive white Gaussian noise (AWGN) and RFI pulses. At the receiver, a soft-decision Viterbi decoder with no quantization and variable truncation length is used to decode the deinterleaved sequence.

  14. Expand MILES spectral library for LAMOST stellar parameter determination using Chinese 2.4 and 2.16 metereter telescopes

    Science.gov (United States)

    Wang, Chun; Liu, Xiaowei; Huang, Yang; Zuo, Fang; Yuan, Haibo; Ren, Juanjuan; Chen, Bingqiu; Xiang, Maosheng; Zhang, Huawei; Luo, Ali; Shi, Jianrong

    2015-08-01

    We present a new medium resolution (full width at half-maximum FWHM ~ 2.4 Å) spectral library containing 1903 stellar spectra with a wavelength coverage of 3800-9000 Å based on MILES spectral library which contains 985 blue arm spectra with wavelength coverage of 3500-7500 Å at a spectral resolution of 2.5 Å (FWHM). The spectra are observed with Chinese Xinglong 2.16 meter telescope of blue arm spectra (with wavelength coverage 3800-5180 Å ) and Gaomeigu 2.4 meter telescope of red arm spectra (with wavelength coverage 5150-9000 Å ), respectively. This new library aims to improve the stellar atmospheric parameters determination accuracy of LAMOST Stellar Parameter Pipeline at Peking University (LSP3) and minimize the limitation of LSP3 . It also could be used in the spectral synthesis of stellar populations of galaxies and many other astronomical fields. Now 560 blue arm and 496 red arm spectra have been observed and reduced. The accuracy of wavelength-calibration and flux-calibration are better than ~ 0.3 Å and ~ 5 per cent, respectively. The mean signal to noise ratios of all spectra are almost larger than 100 per Å.

  15. Conformational alterations induced by novel green 16-E2-16 gemini surfactant in xanthine oxidase: Biophysical insights from tensiometry, spectroscopy, microscopy and molecular modeling.

    Science.gov (United States)

    Akram, Mohd; Bhat, Imtiyaz Ahmad; Bhat, Waseem Feeroze; Kabir-ud-Din

    2015-11-01

    Herein we report the interaction of a biodegradable gemini surfactant, ethane-1,2-diyl bis(N,N-dimethyl-N-hexadecylammoniumacetoxy) dichloride (16-E2-16) with bovine milk xanthine oxidase (XO), employing tensiometry, fluorescence spectroscopy, UV spectroscopy, far-UV circular dichroism spectroscopy (CD), Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and computational molecular modeling. Surface tension results depict substantial changes in the micellar as well as interfacial parameters (CMC, ΠCMC, γCMC, Γmax, Amin, ΔGmic° and ΔGads°) of 16-E2-16 gemini surfactant upon XO combination, deciphering the interaction of XO with the gemini surfactant. Fluorescence measurements reveal that 16-E2-16 gemini surfactant causes quenching in the xanthine oxidase (XO) fluorescence spectra via static procedure and the values of various evaluated binding parameters (KSV, Kb, kq, ΔGb° and n) describe that 16-E2-16 effectively binds to XO. Three dimensional fluorescence, 8-anilino-1-naphthalene sulfonic acid (ANS) binding, F1F3 ratio, UV, CD, FTIR, SEM and TEM results delineate changes in the secondary structure of xanthine oxidase. Molecular docking results provide complement to the steady-state fluorescence findings and support the view that quenching occurs due to non-polar environment experienced by aromatic residues of the enzyme. The results of this study can help scientists to tune the conformation of an enzyme (XO) with biocompatible amphiphilic microstructures, which will help to unfold further understanding in the treatment modes of various diseases like gout, hyperuricemia, liver and brain necrosis. PMID:26057098

  16. Expression of serum microRNAs( miR-222,miR-181,miR-216 ) in human hepatocellular carcinoma and its clinical significance

    Institute of Scientific and Technical Information of China (English)

    占美晓

    2013-01-01

    Objective To investigate the abnormal expression of microRNAs (miR-216,miR-222,miR-181) in the serum of patients with hepatocellular carcinoma (HCC) and its clinical significance.Methods Serum miRNAs expression was investigated in 49 patients with HCC and 25healthy normal controls by using real-time PCR technique,and then correlations between miRNAs expression

  17. Advanced Hodgkin's lymphoma: results in 216 patients treated with ABVD in Brazil Linfoma de Hodgkin em estádio avançado: resultados do tratamento em 216 pacientes tratados com ABVD no Brasil

    Directory of Open Access Journals (Sweden)

    Luciana Britto

    2010-01-01

    Full Text Available The outcome of Hodgkin's lymphoma (HL has markedly improved over the last few decades, placing HL among the human cancers with highest cure rates. However, data about treatment outcomes in developing countries are scarce. From 1996 to 2005, 370 consecutive patients with HL treated in three public institutions in Rio de Janeiro were identified. A total of 216 patients who presented with advanced stage (IIB-IV HL were selected for the present analysis. Patients with advanced disease were treated with ABVD, complemented or not by radiation therapy. The median follow-up time of survivors was 6.3 years (1-11.8. Fifteen patients died during first-line treatment. The complete remission rate was 80%. The 5-year progression-free survival (PFS and the 5-year overall survival (OS probabilities were 69% and 83%, respectively. The 5-year PFS in low-risk and high-risk patients were 81% and 62% (p=0.003, respectively. The 5-year OS in low-risk and high-risk International Prognostic Score patients were 89% and 78% (p=0.02, respectively. The present study provides a representative estimate of current treatment results for advanced HL in public institutions in an urban area in Brazil. It is clear that full treatment can be given to most patients, although those with very low socio-economic status might require special attention and support. Since Brazil is a large country, with substantial interregional heterogeneity, a nationwide registry of HL patients is currently being implemented.Os resultados do tratamento do linfoma de Hodgkin (LH melhoraram substancialmente ao longo das últimas décadas e tornaram o LH uma das neoplasias humanas com maior chance de cura. Entretanto, os dados sobre tratamento em países em desenvolvimento são escassos. Entre 1996 e 2005, 370 pacientes consecutivos com LH tratados em três instituições públicas no Rio de Janeiro foram identificados. Destes, 216 em estádio avançado (IIB-IV foram selecionados para esta análise. Os

  18. 216例神经科重症监护病房患者医院感染及病原菌分析%Etiological analysis of 216 cases of hospital-acquired infections in neurology intensive care unit

    Institute of Scientific and Technical Information of China (English)

    姜嘟嘟; 柳毅刚; 詹青

    2013-01-01

    Objective To investigate microbiological etiology of hospital-acquired infections in Neurology ICU and their antibiotic resistance pattern to provide basis for rational antimicrobial therapy. Methods The pathogens of hospital-acquired infections in 216 NICU patients and the results of susceptibility testing from January 1 , 2008 to December 31 , 2011 were analyzed retrospectively. Results The top three infections were pneumonia (including 39 ventilator-associated pneumonia), urinary tract infection (including 91 catheter-associated urinary tract infections), and bloodstream infection (including 11 central venous catheter-related bloodstream infections). A total of 582 strains of pathogens were collected, of which gram negative bacilli, gram positive cocci and fungal pathogens accounted for 65. 5%, 24. 9% and 9. 6% , respectively. The top five gram-negative rods were Klebsiella pneumoniae (25.2%), Pseudomonas aeruginosa (22.3%), Acinetobacter baumannii (18.1%), Escherichia coli (17.3%) and Proteus mirabilis (4.5%). The top gram-positive pathogens were Staphylococcus aureus (43.4%), Staph-ylococcus haemolyticus (17.2%), Enterococcus faeciumv (8.3%), Staphylococcus epidermidis (8.3%). and Enterococcus gallinarum (4. 8%). Candida albicans was the most frequently reported fungal pathogen. Most strains of gram negative rods were highly susceptible to carbapenems, cefoperazone-sulbactam and piperacillin-tazobactam, but resistant to aminoglycosides and fluoroquinolones. The resistance of Acinetobacter baumannii was serious, including 29% (20/69) extensively drug-resistant strains. The strains of Acinetobacter baumannii were highly susceptible to only cefoperazone-sulbactam. Strains of gram positive cocci were highly susceptible to vancomycin and linezolid. Conclusions Most of the hospital infections in NICU are device-related infections, including ventilator-associated pneumonia, catheter-associated urinary tract infections, and central venous catheter-related bloodstream

  19. 光动力疗法治疗鲜红斑痣1 216例临床分析%A Clinic Analysis of 1 216 Cases of Port Wine Stain Treated by Photodynamic Therapy

    Institute of Scientific and Technical Information of China (English)

    顾瑛; 刘凡光; 王开; 朱建国; 梁洁; 潘玉明; 李峻亨

    2001-01-01

    目的 分析比较血啉甲醚(HMME)与血卟啉衍生物(HpD)为光敏剂行光动力治疗(PDT)鲜红斑痣的临床疗效及副反应。 材料与方法 鲜红斑痣患者1 216例,粉红型13.2%,紫红型68.3%,增厚型18.4%。静脉注射HpD或HMME 3~7 mg/kg后给予铜蒸气激光、KTD/532激光或氩离子激光照射,功率密度50~100 mW/cm2,能量密度90~540 J/cm2,随访观察。 结果 HMME-PDT和HpD-PDT对各型鲜红斑痣均能有效地消除病变颜色,所随访的1 632个病灶在2个月至9年的随访期内未见复发。治疗后反应有:局部水肿5~7天,部分患者有结痂或一过性色素沉着,皮肤暂时性光过敏反应。HpD-PDT组避光期30~90天,HMME-PDT组避光期7~14天。与HpD-PDT相比,HMME-PDT具有反应轻、愈合快、不良反应少、安全度大、避光期短、色素沉着轻、护理容易、重复治疗间隔期短的特点。 结论 HMME-PDT与HpD-PDT都能有效治疗各型鲜红斑痣,但HMME-PDT具有不良反应少、安全度大、避光期短、护理容易、重复治疗间隔期短等优点。%Objective To compare the clinic characteristics of a new kind of photosensitizer-hematoporphyrin monomethyl ether(HMME) which can be quickly eliminated from body and has shorter period of skin photosensitivity with HpD in PWS treatment. Methods 1 216 PWS patients with 13.2% pink, 68.3% purple and 18.4% thickened type were irradiated by copper vapor laser, KTP/532 laser or Argon laser with power densities from 50 to 100 mW/cm2 and energy densities from 90 to 540 J/cm2 after 3 to 7mg/kg HMME or HpD intravenous injection. Results Results revealed that both HMME-PDT and HpD-PDT were able to cure all types of PWS and yielded similar color faded therapeutic effects. The follow-up for 1 632 treated lesions were made from 2 months to 9 years following treatment. No instance of recurrence was found. The reactions and healing procedures after the treatment included 5 to

  20. Spectroscopic study of globular clusters in the halo of M31 with the Xinglong 2.16 m telescope

    Institute of Scientific and Technical Information of China (English)

    Zhou Fan; Ya-Fang Huang; Jin-Zeng Li; Xu Zhou; Jun Ma; Hong Wu; Tian-Meng Zhang; Yong-Heng Zhao

    2011-01-01

    We present spectroscopic observations for 11 confirmed globular clusters (GCs) of M31 with the OMR spectrograph on the 2.16m telescope at the Xinglong site of National Astronomical Observatories,Chinese Academy of Sciences.Nine of our sample clusters are located in the halo of M31 and the most remote one is out to a projected radius of 78.75 kpc from the galactic center.For all our sample clusters,we measured the Lick absorption-line indices and radial velocities.It is noted that most GCs in our sample are distinct from the HI rotation curve of galaxy M31,especially for B514,MCGC5,H12 and B517,suggesting that most of our sample clusters do not have a kinematic association with the star-forming young disk of the galaxy.We separately fitted the absorption line indices from the updated stellar population model of Thomas et al.with two different tracks of Cassisi and Padova,by applying the x2-minimization method.The fitting results show that all our sample clusters are older than 10Gyr,and metal-poor (-2.38 ≤ [Fe/H] ≤ -0.91 dex).After merging the spectroscopic metallicity of our work with the previously published ones,we extended the cluster sample out to a projected radius of 117kpc from the galaxy's center.We found the metallicity gradient exists for all the confirmed clusters with a slope of -0.028 ± 0.001 dex kpc-1.However,the slope turns out to be -0.018 + 0.001 dex kpc-1 for all the halo clusters,which is much shallower.If we only consider the outer halo clusters with rp > 25 kpc,the slope becomes -0.010 ± 0.002 dex kpc-1 and if one cluster G001 is excluded from the outer halo sample,the slope is -0.004 ± 0.002 dex kpc-1.Thus,we conclude that the metallicity gradient for M3 l's outer halo clusters is not significant,which agrees well with previous findings.

  1. SOLVENT HOLD TANK SAMPLE RESULTS FOR MCU-14-135/136 AND MCU-14-214/215/216: FEBRUARY AND MARCH 2014 MONTHLY SAMPLES

    Energy Technology Data Exchange (ETDEWEB)

    Fondeur, F.; Taylor-Pashow, K.

    2014-06-30

    SRNL received two sets of SHT samples (MCU-14-135-136 in February 2014 and MCU-14-214-216 in March 2014) for analysis. The samples were analyzed for composition. As with the previous solvent sample results, these analyses indicate that the solvent does not require Isopar® L trimming at this time. However, the addition of TiDG (suppressor) to the blended solvent is recommended. Evidence of possible (slight) isomerization of the solvent, probably Isopar®L or TiDG degradation products, was observed.

  2. Incubation of MDCO-216 (ApoA-IMilano/POPC) with Human Serum Potentiates ABCA1-Mediated Cholesterol Efflux Capacity, Generates New Prebeta-1 HDL, and Causes an Increase in HDL Size.

    Science.gov (United States)

    Kempen, Herman J; Schranz, Dorota B; Asztalos, Bela F; Otvos, James; Jeyarajah, Elias; Drazul-Schrader, Denise; Collins, Heidi L; Adelman, Steven J; Wijngaard, Peter L J

    2014-01-01

    MDCO-216 is a complex of dimeric ApoA-IMilano and palmitoyl oleoyl phosphatidylcholine (POPC), previously shown to reduce atherosclerotic plaque burden. Here we studied the effect of incubation of human plasma or serum with MDCO-216 on cholesterol efflux capacity from J774 cells, on prebeta-1 high density lipoprotein (prebeta-1 HDL) and on HDL size assessed by proton nuclear magnetic resonance ((1)H-NMR). MDCO-216 incubated in buffer containing 4% human serum albumin stimulated both ABCA1-mediated efflux and ABCA1-independent cholesterol efflux from J774 macrophages. When incubated with human serum a dose- and time-dependent synergistic increase of the ABCA1-mediated efflux capacity were observed. Using a commercially available ELISA for prebeta-1 HDL, MDCO-216 as such was poorly detected (12-15% of nominal amount of protein). Prebeta-1 HDL was rapidly lost when human plasma alone is incubated at 37°C. In contrast, incubation of human plasma with MDCO-216 at 37°C produced a large amount of new prebeta-1 HDL. Native 2D electrophoresis followed by immunoblotting with an apoA-I antibody, which also detects ApoA-I Milano, confirmed the increase in prebeta-1 HDL upon incubation at 37°C. With the increase of prebeta-1 HDL, the concomitant disappearance of the small alpha-3 and alpha-4 HDL and MDCO-216 and an increase in the large alpha-1 and alpha-2 HDL were observed. Immunoblotting with Mab 17F3 specific for ApoA-I Milano showed the appearance of ApoA-I Milano in alpha-1 and alpha-2, but not in prebeta-1 HDL. (1)H-NMR analysis of plasma incubated with MDCO-216 confirmed rapid disappearance of small-sized HDL particles and increase of medium- and large-sized HDL particles accompanied with a decrease in total HDL particle number. In conclusion, incubation of human plasma or serum with MDCO-216 strongly enhanced ABCA1-mediated cholesterol efflux, caused a strong increase of prebeta-1 HDL, and drastically changed the distribution of HDL subpopulations. Overall, the

  3. Incubation of MDCO-216 (ApoA-IMilano/POPC with Human Serum Potentiates ABCA1-Mediated Cholesterol Efflux Capacity, Generates New Prebeta-1 HDL, and Causes an Increase in HDL Size

    Directory of Open Access Journals (Sweden)

    Herman J. Kempen

    2014-01-01

    Full Text Available MDCO-216 is a complex of dimeric ApoA-IMilano and palmitoyl oleoyl phosphatidylcholine (POPC, previously shown to reduce atherosclerotic plaque burden. Here we studied the effect of incubation of human plasma or serum with MDCO-216 on cholesterol efflux capacity from J774 cells, on prebeta-1 high density lipoprotein (prebeta-1 HDL and on HDL size assessed by proton nuclear magnetic resonance (1H-NMR. MDCO-216 incubated in buffer containing 4% human serum albumin stimulated both ABCA1-mediated efflux and ABCA1-independent cholesterol efflux from J774 macrophages. When incubated with human serum a dose- and time-dependent synergistic increase of the ABCA1-mediated efflux capacity were observed. Using a commercially available ELISA for prebeta-1 HDL, MDCO-216 as such was poorly detected (12–15% of nominal amount of protein. Prebeta-1 HDL was rapidly lost when human plasma alone is incubated at 37°C. In contrast, incubation of human plasma with MDCO-216 at 37°C produced a large amount of new prebeta-1 HDL. Native 2D electrophoresis followed by immunoblotting with an apoA-I antibody, which also detects ApoA-I Milano, confirmed the increase in prebeta-1 HDL upon incubation at 37°C. With the increase of prebeta-1 HDL, the concomitant disappearance of the small alpha-3 and alpha-4 HDL and MDCO-216 and an increase in the large alpha-1 and alpha-2 HDL were observed. Immunoblotting with Mab 17F3 specific for ApoA-I Milano showed the appearance of ApoA-I Milano in alpha-1 and alpha-2, but not in prebeta-1 HDL. 1H-NMR analysis of plasma incubated with MDCO-216 confirmed rapid disappearance of small-sized HDL particles and increase of medium- and large-sized HDL particles accompanied with a decrease in total HDL particle number. In conclusion, incubation of human plasma or serum with MDCO-216 strongly enhanced ABCA1-mediated cholesterol efflux, caused a strong increase of prebeta-1 HDL, and drastically changed the distribution of HDL subpopulations

  4. High-resolution FUSE and HST ultraviolet spectroscopy of the white dwarf central star of Sh 2-216

    Science.gov (United States)

    Rauch, T.; Ziegler, M.; Werner, K.; Kruk, J. W.; Oliveira, C. M.; Vande Putte, D.; Mignani, R. P.; Kerber, F.

    2007-07-01

    Context: We perform a comprehensive spectral analysis of LS V +46° 21 in order to compare its photospheric properties to theoretical predictions from stellar evolution theory as well as from diffusion calculations. Aims: LS V +46° 21 is the DAO-type central star of the planetary nebula Sh 2-216. High-resolution, high-S/N ultraviolet observations obtained with FUSE and STIS aboard the HST as well as the optical spectrum have been analyzed in order to determine the photospheric parameters and the spectroscopic distance. Methods: We performed a detailed spectral analysis of the ultraviolet and optical spectrum by means of state-of-the-art NLTE model-atmosphere techniques. Results: From the N IV - N V, O IV - O VI, Si IV - Si V, and Fe V - Fe VII ionization equilibria, we determined an effective temperature of (95± 2) kK with high precision. The surface gravity is log g = 6.9± 0.2. An unexplained discrepancy appears between the spectroscopic distance d = 224+46-58 pc and the parallax distance d = 129+6-5 pc of LS V +46° 21. For the first time, we have identified Mg IV and Ar VI absorption lines in the spectrum of a hydrogen-rich central star and determined the Mg and Ar abundances as well as the individual abundances of iron-group elements (Cr, Mn, Fe, Co, and Ni). With the realistic treatment of metal opacities up to the iron group in the model-atmosphere calculations, the so-called Balmer-line problem (found in models that neglect metal-line blanketing) vanishes. Conclusions: Spectral analysis by means of NLTE model atmospheres has presently arrived at a high level of sophistication, which is now hampered largely by the lack of reliable atomic data and accurate line-broadening tables. Strong efforts should be made to improve upon this situation. Based on observations with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract

  5. Metallicity and star formation activities of the interacting system Arp 86 from observations with MOS on the Xinglong 2.16 m telescope

    International Nuclear Information System (INIS)

    We present an analysis of the metallicity and star formation activities of H II regions in the interacting system Arp 86, based on the first scientific observations using multi-object spectroscopy with the 2.16 m telescope at the Xinglong Observing Station. We find that the oxygen abundance gradient in Arp 86 is flatter than that in normal disk galaxies, which confirms that gas inflows caused by tidal forces during encounters can flatten the metallicity distributions in galaxies. The companion galaxy NGC 7752 is currently experiencing a galaxy-wide starburst with a higher star formation rate surface density than the main galaxy NGC 7753, which can be explained in that the companion galaxy is more susceptible to the effects of interaction than the primary. We also find that the galaxy 2MASX J23470758+2926531 has similar abundance and star formation properties to NGC 7753, and may be a part of the Arp 86 system. (research papers)

  6. JM216-, JM118-, and cisplatin-induced cytotoxicity in relation to platinum-DNA adduct formation, glutathione levels and p53 status in human tumour cell lines with different sensitivities to cisplatin

    NARCIS (Netherlands)

    Fokkema, E; Groen, HJM; Helder, MN; de Vries, EGE; Meijer, C

    2002-01-01

    The aim of this study is to establish anti-tumour potency of the new oral platinum drug JM216 and its metabolite JM118 in relation to the platinum (Pt)-DNA adduct formation, glutathione (GSH)-levels, and p53 status in human cancer cell lines with different sensitivities to cisplatin (CDDP). These pa

  7. Draft Genome Sequence of Klebsiella pneumoniae KGM-IMP216 Harboring bla CTX-M-15, bla DHA-1, bla TEM-1B, bla NDM-1, bla SHV-28, and bla OXA-1, Isolated from a Patient in Lebanon

    OpenAIRE

    Tokajian, Sima; Eisen, Jonathan A.; Jospin, Guillaume; Matar, Ghassan; Araj, George F.; Coil, David A.

    2016-01-01

    We present the draft genome of highly drug-resistant Klebsiella pneumoniae KGM-IMP216, isolated from a urine sample collected from a patient in Lebanon. The draft genome sequence consisted of 77 contigs, including a combined 5,731,500 bases with 57% G+C content.

  8. Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes

    International Nuclear Information System (INIS)

    CDC25 phosphatases are important regulators of the cell cycle. Their abnormal expression detected in a number of tumors implies that their dysregulation is involved in malignant transformation. However, the role of CDC25s in vulvar cancer is still unknown. To shed light on their roles in the pathogenesis and to clarify their prognostic values, expression of CDC25A, CDC25B and CDC25C in a large series of vulvar squamous cell carcinomas were examined. Expression of CDC25A, CDC25B, CDC25C and phosphorylated (phospho)-CDC25C (Ser216) were examined in 300 vulvar carcinomas using immunohistochemistry. Western blot analysis was utilized to demonstrate CDC25s expression in vulvar cancer cell lines. Kinase and phosphatase assays were performed to exclude cross reactivity among CDC25s isoform antibodies. High nuclear CDC25A and CDC25B expression were observed in 51% and 16% of the vulvar carcinomas, respectively, whereas high cytoplasmic CDC25C expression was seen in 63% of the cases. In cytoplasm, nucleus and cytoplasm/nucleus high phospho-CDC25C (Ser216) expression was identified in 50%, 70% and 77% of the carcinomas, respectively. High expression of CDC25s correlated significantly with malignant features, including poor differentiation and infiltration of vessel for CDC25B, high FIGO stage, presence of lymph node metastases, large tumor diameter, poor differentiation for CDC25C and high FIGO stage, large tumor diameter, deep invasion and poor differentiation for phospho-CDC25C (Ser216). In univariate analysis, high expression of phospho-CDC25C (Ser216) was correlated with poor disease-specific survival (p = 0.04). However, such an association was annulled in multivariate analysis. Our results suggest that CDC25C and phospho-CDC25C (Ser216) play a crucial role and CDC25B a minor role in the pathogenesis and/or progression of vulvar carcinomas. CDC25B, CDC25C and phospho-CDC25C (Ser216) were associated with malignant features and aggressive cancer phenotypes. However, the

  9. Effects of the Fermented Products of Trichoderma harzianum T2-16 on the Cell Membrane and Cell Protective Enzyme System of Cowpea Seeds%哈茨木霉T2-16发酵产物对豇豆种子细胞膜及细胞保护酶系统的影响

    Institute of Scientific and Technical Information of China (English)

    魏林; 梁志怀; 曹福祥; 陈玉荣

    2011-01-01

    应用哈茨木霉T2-16菌株在改良后的GPF培养基中发酵培养获得的发酵产物,对豇豆种子进行浸种处理,分析了发酵产物在种子萌发过程中主要生理生化过程的影响.结果表明,该发酵产物可增强豇豆体内超氧化歧化酶(SOD)、过氧化氢酶(CAT)和过氧化物酶(POD)等保护酶活性,有效保护种子细胞膜结构的完整性,减少了氨基酸、蛋白质、可溶性糖等胞内营养物质的外渗,从而起到提高豇豆种子活力的效果.%The fermented product of T. harzianum T2-16 strain was applied on cowpea by seed soaking. The effects on the seeds vigor were studied. The results showed that the specific activities of protective enzymes, superoxide dismutase ( SOD), catalase (CAT) and peroxidase (POD) all increased. The fermented substance could also make the cell membrane permeability, decrease the conductivity rate. The contents of protein, dissoluble sugar and amino acids in cell exudates of eowpea seedlings were less than that of treated by water. The seeds vigor of cowpea treated by the fermented product were significantly improved.

  10. Perfusion pattern and time of vascularisation with CEUS increase accuracy in differentiating between benign and malignant tumours in 216 musculoskeletal soft tissue masses

    Energy Technology Data Exchange (ETDEWEB)

    De Marchi, Armanda, E-mail: armanda.demarchi@tiscali.it [Department of Imaging, Azienda Ospedaliera Città della Salute e della Scienza, CTO Hospital, Via Zuretti 29, 10126 Torino (Italy); Prever, Elena Brach del, E-mail: elena.brach@unito.it [Department of OrthopaedicOncology and ReconstructiveSurgery, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, CTO Hospital, Via Zuretti 29, 10126 Torino (Italy); Cavallo, Franco, E-mail: franco.cavallo@unito.it [Department of Public health and Paediatrics, University of Turin, Via Santena 5-bis, 10126 Torino (Italy); Pozza, Simona, E-mail: simona.pozza@tin.it [Department of Imaging, Azienda Ospedaliera Città della Salute e della Scienza, CTO Hospital, Via Zuretti 29, 10126 Torino (Italy); Linari, Alessandra, E-mail: linaralessandra@libero.it [Department of Pathology, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Regina Margherita Hospital, Piazza Polonia, 10126 Torino (Italy); Lombardo, Paolo, E-mail: pao.lombardo82@gmail.com [Department of DiagnosticImaging and Radiotherapy of the University of Turin, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Via Genova 3, 10126 Torino (Italy); Comandone, Alessandro, E-mail: alessandro.comandone@gradenigo.it [Department of Oncology, Gradenigo Hospital, Corso Regina Margherita, 8/10.10153 Torino (Italy); Piana, Raimondo, E-mail: raimondo.piana@libero.it [Department of OrthopaedicOncology and ReconstructiveSurgery, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, CTO Hospital, Via Zuretti 29, 10126 Torino (Italy); Faletti, Carlo [Department of Imaging, Azienda Ospedaliera Città della Salute e della Scienza, CTO Hospital, Via Zuretti 29, 10126 Torino (Italy)

    2015-01-15

    Introduction: Musculoskeletal Soft Tissue Tumours (STT) are frequent heterogeneous lesions. Guidelines consider a mass larger than 5 cm and deep with respect to the deep fascia potentially malignant. Contrast Enhanced Ultrasound (CEUS) can detect both vascularity and tumour neoangiogenesis. We hypothesised that perfusion patterns and vascularisation time could improve the accuracy of CEUS in discriminating malignant tumours from benign lesions. Materials and methods: 216 STT were studied: 40% benign lesions, 60% malignant tumours, 56% in the lower limbs. Seven CEUS perfusion patterns and three types of vascularisation (arterial-venous uptake, absence of uptake) were applied. Accuracy was evaluated by comparing imaging with the histological diagnosis. Univariate and multivariate analysis, Chi-square test and t-test for independent variables were applied; significance was set at p < 0.05 level, 95% computed CI. Results: CEUS pattern 6 (inhomogeneous perfusion), arterial uptake and location in the lower limb were associated with high risk of malignancy. CEUS pattern has PPV 77%, rapidity of vascularisation PPV 69%; location in the limbs is the most sensitive indicator, but NPV 52%, PPV 65%. The combination of CEUS-pattern and vascularisation has 74% PPV, 60% NPV, 70% sensitivity. No correlation with size and location in relation to the deep fascia was found. Conclusion: US with CEUS qualitative analysis could be an accurate technique to identify potentially malignant STT, for which second line imaging and biopsy are indicated in Referral Centers. Intense inhomogeneous enhancement with avascular areas and rapid vascularisation time could be useful in discriminating benign from malignant SST, overall when the lower limbs are involved.

  11. Produção de brotos de soja utilizando a cultivar BRS 216: caracterização físico-química e teste de aceitabilidade Production of soybean sprouts from the cultivar BRS 216: physical and chemical characterization and acceptability test

    Directory of Open Access Journals (Sweden)

    Marcelo Alvares de Oliveira

    2013-03-01

    Full Text Available O presente trabalho teve por objetivo avaliar os parâmetros físico-químicos e os processos para a produção de brotos de soja a partir de sementes da cultivar BRS 216, bem como sua composição química e aceitabilidade. Foram avaliados o comprimento e o peso dos brotos viáveis, a composição centesimal e os teores de isoflavonas e de inibidor de tripsina. O desenho experimental foi ao acaso com três repetições e os tratamentos foram avaliados num esquema fatorial 3 × 3: três frequências de irrigação (a cada quatro, oito e 12 horas e três períodos de crescimento (cinco, seis e sete dias. O teste de aceitabilidade dos brotos de soja foi realizado utilizando-se a escala hedônica estruturada de nove pontos, avaliando-se cor, aparência, odor, textura, sabor e avaliação global, além da intenção de compra. A frequência de irrigação com intervalos de quatro horas e o período de sete dias de crescimento foram ideais para produção dos brotos de soja, favorecendo maior produtividade, teores mais elevados de proteínas e menores teores de inibidor de tripsina. O índice de aceitabilidade dos brotos de soja foi superior a 70 em todas as características avaliadas, com exceção do odor.The aim of the present study was to evaluate the physical and chemical parameters and process for the production of soybean sprouts from the BRS 216 cultivar, as well as determining their chemical composition and acceptability. The length and weight of viable sprouts, proximate composition, and the isoflavone and trypsin inhibitor contents were evaluated. The experimental design was completely randomized with three replications, and the treatments were evaluated using a 3 × 3 factorial design: three irrigation frequencies (four, eight and 12 hours and three growth periods (five, six and seven days. The soybean sprout acceptability was determined using a nine point structured hedonic scale, evaluating colour, appearance, aroma, texture, flavour

  12. 哈茨木霉T_(2-16)菌剂不同使用方法对花生防病促生长效果的研究%Effect of Different Application Methods of Trichoderma harzianum T2-16 on Peanut Growth Promotion and Disease Prevention

    Institute of Scientific and Technical Information of China (English)

    王献慧; 梁志怀; 魏林; 陈玉荣; 张屹

    2012-01-01

    应用哈茨木霉菌T2-16菌剂对花生进行木霉拌种和浸种处理,研究木霉对花生防病促生长的效果。结果表明,供试木霉菌剂两种使用方法对病害防治效果和促生长作用均好于对照,其中木霉菌剂拌种处理的效果又优于浸种处理。拌种处理后荚果产量、饱果产量和籽仁产量分别比对照提高了32.4%、36.8%和33.8%,而其秕果重量比对照降低了29.8%,其叶斑病发病率比对照降低了8.79%,防效为64.63%,其烂果数比对照少了3.18个,防效为60.6%。%Seed dressing and seed soaking with Trichoderma harzianum T2-16 were applied to pea- nut in order to research the effect of Trichoderma on disease prevention and growth promotion in pea- nut. Results indicated that the effect of two application methods of Trichoderma on disease prevention and growth promotion was better than the control, and the effect of Trichoderma dressed seed was better than that of Trichoderrna soaked seed. The pod yield, the plump pod yield and the kernel yield of peanut treated by seed dressing were 32.3%, 36.8% and 33.8% more than that of control, respec- tively. Its blighted pod weight was 29.8% less than that of control. The incidence of leaf spot was 8.79% less than that of control, which showed the efficiency of disease prevention was 64.6 %. The number of rotten pod was 3.18 less than that control, which showed the efficiency of disease prevention was 60.6%.

  13. Formación de la Aleación Zn-21.6%Al-2.0%Cu por Pulvimetalurgia: Efecto del Lubricante en las Briquetas Formation of Zn-21.6%Al-2.0%Cu Alloy by Powder Metallurgy: Effect of the Lubricant in Briquettes

    Directory of Open Access Journals (Sweden)

    José A Aragón

    2008-01-01

    Full Text Available En este trabajo se presenta la elaboración de la aleación Zn-21.6%Al-2.0%Cu (porcentajes en masa, por un método de metalurgia de polvos y se analiza el efecto de distintos lubricantes, usados en las briquetas. Se elaboraron mezclas de polvos de Zn, Al y Cu con acetona, cera y ácido esteárico como lubricantes, y se compactaron uniaxialmente a una presión de 77.4 MPa. Las briquetas se sinterizaron bajo un flujo de argón y en intervalos de 15 minutos a 357 °C. Los materiales fueron caracterizados estructuralmente con microscopio óptico, ensayos de microdureza Vickers, dureza Rockwell F y difracción de rayos X. El ácido esteárico y la cera funcionan similarmente como lubricantes y la acetona retarda la formación de la aleación, pero causa mayores durezas, luego del sinterizado. La aleación se forma totalmente cuando el lubricante es cera y se sinteriza más de 45 minutos. La rapidez de formación de la aleación depende del tipo de lubricante en las briquetas.In this work the elaboration of Zn-21.6%Al-2.0%Cu alloy (mass percentages, prepared by a method of powder metallurgy and the effect of different lubricants used in the briquettes were studied. Mixtures of powders of Zn, Al and Cu with acetone, wax and stearic acid as lubricants were prepared and compacted up to a pressure of 77.4 Mpa. The briquettes were sintered under argon flux and at intervals of 15 and 45 minutes at 357° C. The materials were structurally characterized by optical microscopy, micro-hardness Vickers, hardness Rockwell F tests and X-rays diffraction. The stearic acid and wax work similar to lubricants and acetone slows down the formation of the alloy, but it causes greater hardnesses after sintering. The alloy is completely formed when the lubricant is wax and the sintering time is more than 45 minutes. The velocity of formation of the alloy depends on the type of lubricant in the briquettes.

  14. Spectroscopic study of globular clusters in the halo of M31 with the Xinglong 2.16m telescope Ⅱ dynamics, metallicity and age

    Institute of Scientific and Technical Information of China (English)

    Zhou Fan; Ya-Fang Huang; Jin-Zeng Li; Xu Zhou; Jun Ma; Yong-Heng Zhao

    2012-01-01

    In Paper I,we performed spectroscopic observations on 11 confirmed globular clusters(GCs)in M31 with the Xinglong 2.16 m telescope.We mainly focused on the fitting method and the metallicity gradient for the M31 GC sample.Here,we analyze and further discuss the dynamics,metallicity and age,and their distributions,as well as the relationships between these parameters.In our work,eight more confirmed GCs in the halo of M31 were observed,most of which lack previous spectroscopic information.These star clusters are located far from the galactic center at a projected radius of ~ 14 to ~ 117 kpc,which is more spatially extended than that in the previous work.Firstly,we measured the Lick absorption-line indices and the radial velocities.Then the ages and metallicity values of [Fe/H] and [α/Fe] were fitted by comparing the observed spectral feature indices and the Single Stellar Population model of Thomas et al.in the Cassisi and Padova stellar evolutionary tracks,respectively.Our results show that most of the star clusters in our sample are older than 10 Gyr except B290,which is ~ 5.5 Gyr,and most of them are metal-poor with metallicity [Fe/H] < -1,suggesting that these clusters were born at the early stage of the galaxy's formation.We find that the metallicity gradient for the outer halo clusters with Υp > 25 kpc may have an insignificant slope of-0.005 ± 0.005 dex kpc-1 and if the outliers G001 and H1 1 are excluded,the slope does not change significantly,with a value of-0.002 ± 0.003 dex kpc-1.We also find that the metallicity is not a function of age for the GCs with age < 7 Gyr,but for the old GCs with age > 7 Gyr,there seems to be a trend that the older ones have lower metallicity.Additionally,we plot metallicity distributions with the largest sample of M31 GCs so far and show the bimodality is not significant,and the number of metal-poor and metal-rich groups becomes comparable.The spatial distributions show that the metal-rich group is more

  15. 通光口径2.16 m天文望远镜凹双曲面主镜的磨制工艺%The technology of the concave hyperbolic primary mirror of the effective aperture 2.16m astronomical telescope

    Institute of Scientific and Technical Information of China (English)

    李德培

    2001-01-01

    2.16 m光学望远镜是目前我国研制的口径最大的反射式天文望远镜,主镜通光口径为2.16 m,边厚为330 mm,重量约2 200 kg,顶点曲率半径R0=12 960 mm,偏心率平方e2=1.095 134 7[1],相对口径为1/3,最大非球面度δ0max≈21 μm.由于所用玻璃毛坯为原苏联制造,质量极差,通体充满气泡、结石、折叠,是块等外品.更致命的是磨出的表面各处硬度不均匀,出现大面积、形状不规则的高、低区,不得不用手持小抛光盘进行手修,像雕刻一样去掉那些不规则形状的硬的局部高,保留不规则的软的局部低(所谓修光程),并把它拼凑成一个较为接近的理想双曲面.可以想像得出,这样做会遇到多麽大的困难.在大家的努力下,终于用手把它磨修到尽可能完善.最后望远镜在由该主镜、凸双曲面副镜及熔石英像场改正镜组成的R-C卡塞格林(Ritchey-Chretien Cassegrain)光学系统的焦面上拍摄了星团底片.经鉴定委员会测试组专家测量后认为,在全视场(300 mm×300 mm)内,不管是边、角还是中心像均很圆,暗星像直径达0.18 mm.说明主镜的加工工艺是成功的,同时也说明凸双曲面副镜的加工、检验[2],熔石英像场改正镜的设计[1]、选料、加工[3]及光学系统的调整[4]也是成功的.

  16. Survey of organophosphate resistance and an Ala216Ser substitution of acetylcholinesterase-1 gene associated with chlorpyrifos resistance in Apolygus lucorum (Meyer-Dür) collected from the transgenic Bt cotton fields in China.

    Science.gov (United States)

    Zhen, Congai; Miao, Ling; Liang, Pei; Gao, Xiwu

    2016-09-01

    The mirid bug is frequently controlled by the application of organophosphorus insecticides in the transgenic Bt cotton field of China. A topical bioassay method was performed to evaluate the toxicities of chlorpyrifos and malathion towards field-collected Chinese populations of Apolygus lucorum from transgenic Bt cotton fields. For chlorpyrifos, the resistance ratios ranged from 0.8 to 9.4-fold compared to a susceptible strain. For malathion, the resistance levels relative to the susceptible strain ranged from 1.2 to 14.4-fold. Compared to a susceptible strain, the Cangzhou population from Hebei province showed the highest resistance ratios towards these insecticides. A comparison of the detoxifying and target enzyme activities between the Cangzhou population and a susceptible strain revealed that altered acetylcholinesterase possibly account for the chlorpyrifos and malathion resistance in the Cangzhou population. Two acetylcholinesterase (AChE-encoding) genes (designated Alace1 and Alace2) from the green mirid bug (A. lucorum) were identified. The Alace1 and Alace2 genes encoded 597 and 645 amino acids, respectively. Both AChE proteins had conserved motifs including a catalytic triad, a choline-binding site, and an acyl pocket. Quantitative real-time PCR analysis showed that Alace1 had a much higher transcriptional level than Alace2, for the expression profiles of both spatial and time distributions. One amino acid substitution, Ala216Ser in Alace1, was found in the Cangzhou population. These results suggest that the mutation Ala216Ser should be most likely involved in organophosphorus resistance in A. lucorum. PMID:27521910

  17. The Big-Wheel TGC-1 being moved against the Barrel Muon Spectrometer. The 216 trigger chambers are supported by a thin structure of 22 m diameter and 0.4 m thickness, weighting 44 tons and supported on two rails.

    CERN Multimedia

    Claudia Marcelloni

    2006-01-01

    The Big-Wheel TGC-1 being moved against the Barrel Muon Spectrometer. The 216 trigger chambers are supported by a thin structure of 22 m diameter and 0.4 m thickness, weighting 44 tons and supported on two rails.

  18. Complete 2mm Spectral Line Survey (130-170 GHz) of Sgr B2N, Sgr B2OH, IRC +10 216, Orion (KL), Orion-S, W51M, and W3(IRS5)

    CERN Document Server

    Remijan, Anthony J; Markwick-Kemper, A J; Turner, B E

    2008-01-01

    We report a complete 2mm spectral line survey (130-170 GHz) taken with the NRAO 12m Telescope between 1993 and 1995 toward the following sources: Sgr B2N, Sgr B2OH, IRC +10 216, Orion (KL), Orion-S, W51M, and W3(IRS5). Until very recently, this project was entirely the work of B. E. Turner. He wrote the original proposal, given below without changes or updates, and did all of the observing. B.E. Turner has fallen seriously ill and can no longer continue to work on the analysis of these data. The notes that follow the proposal give further information about the project and important information for users of these data. The data are distributed using the Spectral Line Search Engine (SLiSE) developed by A. J. Remijan and M. J. Remijan. SLiSE is a data display tool that will contain all the fully reduced and calibrated archived data taken as part of this 2mm survey. SLiSE is fast, easy to use, and contains the necessary functionality to display the data taken from spectral line searches. For example, SLiSE contai...

  19. THE FIRST Hi-GAL OBSERVATIONS OF THE OUTER GALAXY: A LOOK AT STAR FORMATION IN THE THIRD GALACTIC QUADRANT IN THE LONGITUDE RANGE 216. Degree-Sign 5 {approx}< l {approx}< 225. Degree-Sign 5

    Energy Technology Data Exchange (ETDEWEB)

    Elia, D.; Molinari, S.; Schisano, E.; Pestalozzi, M.; Benedettini, M.; Di Giorgio, A. M.; Pezzuto, S.; Rygl, K. L. J. [Istituto di Astrofisica e Planetologia Spaziali-INAF, Via Fosso del Cavaliere 100, I-00133 Roma (Italy); Fukui, Y.; Hayakawa, T.; Yamamoto, H. [Department of Physics, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602 (Japan); Olmi, L. [Osservatorio Astrofisico di Arcetri-INAF, Largo E. Fermi 5, I-50125 Firenze (Italy); Veneziani, M. [Infrared Processing and Analysis Center, California Institute of Technology, Pasadena, CA 91125 (United States); Schneider, N.; Piazzo, L. [IRFU/SAp CEA/DSM, Laboratoire AIM CNRS, Universit Paris Diderot, F-91191 Gif-sur-Yvette (France); Ikhenaode, D. [DIET-Dipartimento di Ingegneria dell' Informazione, Elettronica e Telecomunicazioni, Universita di Roma La Sapienza, via Eudossina 18, I-00184 Roma (Italy); Mizuno, A. [Solar-Terrestrial Environment Laboratory, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601 (Japan); Onishi, T. [Department of Physical Science, Osaka Prefecture University, Sakai, Osaka 599-8531 (Japan); Polychroni, D. [Department of Astrophysics, Astronomy and Mechanics, Faculty of Physics, University of Athens, Panepistimiopolis, 15784 Zografos, Athens (Greece); Maruccia, Y., E-mail: davide.elia@iaps.inaf.it [Dipartimento di Matematica e Fisica, Universita del Salento, CP 193, I-73100 Lecce (Italy)

    2013-07-20

    We present the first Herschel PACS and SPIRE photometric observations in a portion of the outer Galaxy (216. Degree-Sign 5 {approx}< l {approx}< 225. Degree-Sign 5 and -2 Degree-Sign {approx}< b {approx}< 0 Degree-Sign ) as a part of the Hi-GAL survey. The maps between 70 and 500 {mu}m, the derived column density and temperature maps, and the compact source catalog are presented. NANTEN CO(1-0) line observations are used to derive cloud kinematics and distances so that we can estimate distance-dependent physical parameters of the compact sources (cores and clumps) having a reliable spectral energy distribution that we separate into 255 proto-stellar and 688 starless sources. Both typologies are found in association with all the distance components observed in the field, up to {approx}5.8 kpc, testifying to the presence of star formation beyond the Perseus arm at these longitudes. Selecting the starless gravitationally bound sources, we identify 590 pre-stellar candidates. Several sources of both proto- and pre-stellar nature are found to exceed the minimum requirement for being compatible with massive star formation based on the mass-radius relation. For the pre-stellar sources belonging to the Local arm (d {approx}< 1.5 kpc) we study the mass function whose high-mass end shows a power law N(log M){proportional_to}M {sup -1.0{+-}0.2}. Finally, we use a luminosity versus mass diagram to infer the evolutionary status of the sources, finding that most of the proto-stellar sources are in the early accretion phase (with some cases compatible with a Class I stage), while for pre-stellar sources, in general, accretion has not yet started.

  20. Evaluation of a Wet Chemistry Method for Isolation of Cyclotron Produced [211At]Astatine

    Directory of Open Access Journals (Sweden)

    Shigeki Watanabe

    2013-09-01

    Full Text Available A “wet chemistry” approach for isolation of 211At from an irradiated bismuth target is described. The approach involves five steps: (1 dissolution of bismuth target in conc. HNO3; (2 removal of the HNO3 by distillation; (3 dissolution of residue in 8 M HCl; (4 extraction of 211At from 8 M HCl into DIPE; and (5 extraction of 211At from DIPE into NaOH. Results from 55 “optimized” 211At isolation runs gave recovery yields of approximately 78% after decay and attenuation corrections. An attenuation-corrected average of 26 ± 3 mCi in the target provided isolated (actual yields of 16 ± 3 mCi of 211At. A sixth step, used for purification of 211At from trace metals, was evaluated in seven runs. In those runs, isolated 211At was distilled under reductive conditions to provide an average 71 ± 8% recovery. RadioHPLC analyses of the isolated 211At solutions, both initial and after distillation, were obtained to examine the 211At species present. The primary species of 211At present was astatide, but astatate and unidentified species were also observed. Studies to determine the effect of bismuth attenuation on 211At were conducted to estimate an attenuation factor (~1.33 for adjustment of 211At readings in the bismuth target.

  1. Production of Astatine-211 at the Duke University Medical Center for its regional distribution

    Energy Technology Data Exchange (ETDEWEB)

    Zalutsky, Michael [Duke University Medical Center, Durham, NC (United States)

    2016-01-01

    Systemic targeted radiation therapy and radioimmunotherapy continue to be important tools in the treatment of certain cancers. Because of their high energy and short path length, alpha particle emitters such as 211At are more effective than either external beam x- ray or in vivo beta radiation in delivering potentially curative doses of radiation. The limited clinical trials that have been conducted to date have yielded encouraging responses in some patients, e.g., malignant brain tumors. In order to escalate the additional necessary research and development in radiochemistry, radiobiology and efficacy evaluation of alpha particle radiotherapeutics, it is universally agreed that access to an affordable, reliable supply of 211At is warranted. In conjunction with the Department of Energy's intent to enhance stable and radioactive isotope availability for research applications, it is the primary objective of this project to improve 211At production and purification capabilities at Duke so that this radionuclide can be supplied to researchers at other institutions throughout the US.The most widely used 211At production method involves the α,2n reaction on Bismuth using a cyclotron with beams ≤ 28 MeV. Yields can be enhanced with use of an internal target that allows for a higher alpha fluence plus efficient heat dissipation in the target. Both of these items are in place at Duke; however, in order to support production for multi-institutional use, irradiation campaigns in excess of 50 µAp and four hours duration will be needed. Further, post-irradiation processing equipment is lacking that will enable the distribution process. Financial support is sought for i) a shielded, ventilated processing/containment hood; ii) development of a post-irradiation target retrieval system; iii) fabrication of a 211At distillation and recovery module and iv) a performance review and, where needed, an enhancement of seven major subsystems that comprise the CS-30 Cyclotron. With these modifications in place, routine production of ≥200 mCi of At-211 should be readily achievable, given our methodological development of At-211 target preparation, internal target irradiation and dry distillation to recover the radionuclide.

  2. Final Report for grant entitled "Production of Astatine-211 for U.S. Investigators"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, Daniel Scott

    2012-12-12

    Alpha-particle emitting radionuclides hold great promise in the therapy of cancer, but few alpha-emitters are available to investigators to evaluate. Of the alpha-emitters that have properties amenable for use in humans, 211At is of particular interest as it does not have alpha-emitting daughter radionuclides. Thus, there is a high interest in having a source of 211At for sale to investigators in the US. Production of 211At is accomplished on a cyclotron using an alpha-particle beam irradiation of bismuth metal. Unfortunately, there are few cyclotrons available that can produce an alpha particle beam for that production. The University of Washington has a cyclotron, one of three in the U.S., that is currently producing 211At. In the proposed studies, the things necessary for production and shipment of 211At to other investigators will be put into place at UW. Of major importance is the efficient production and isolation of 211At in a form that can be readily used by other investigators. In the studies, production of 211At on the UW cyclotron will be optimized by determining the best beam energy and the highest beam current to maximize 211At production. As it would be very difficult for most investigators to isolate the 211At from the irradiated target, the 211At-isolation process will be optimized and automated to more safely and efficiently obtain the 211At for shipment. Additional tasks to make the 211At available for distribution include obtaining appropriate shipping vials and containers, putting into place the requisite standard operating procedures for Radiation Safety compliance at the levels of 211At activity to be produced / shipped, and working with the Department of Energy, Isotope Development and Production for Research and Applications Program, to take orders, make shipments and be reimbursed for costs of production and shipment.

  3. 36 CFR 216.2 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... consists of numerous volumes organized by numerically coded subject matter. The volumes contain legal..., regulations, or management needs. (b) Public participation activities are actions initiated by the Forest... Manual which establish the general framework for the management and conduct of Forest Service programs....

  4. 10 CFR 216.2 - Definitions.

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    2010-01-01

    ... maximizes domestic energy supplies by furthering the exploration, production, refining, transportation or... related activity. Such term also includes emergency preparedness activities conducted pursuant to title VI of the Robert T. Stafford Disaster Relief and Emergency Assistance Act (42 U.S.C. 5195, et seq.)...

  5. 50 CFR 216.180 - Specified activity.

    Science.gov (United States)

    2010-10-01

    ... macrorhynchus and G. melas). (3) Pinnipeds—hooded seal (Cystophora cristata), harbor seal (Phoca vitulina), spotted seal (P. largha), ribbon seal (P. fasciata), gray seal (Halichoerus grypus), elephant seal (Mirounga angustirostris and M. leonina), Hawaiian monk seal (Monachus schauinslandi), Mediterranean...

  6. 50 CFR 216.15 - Depleted species.

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    2010-10-01

    ... Assistant Administrator as depleted under the provisions of the MMPA. (a) Hawaiian monk seal (Monachus schauinslandi). (b) Bowhead whale (Balaena mysticetus). (c) North Pacific fur seal (Callorhinus...

  7. 50 CFR 216.274 - Mitigation.

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    2010-10-01

    ... watchstander in accordance with the Lookout Training Handbook (Naval Education and Training Command 12968-D... communication within the command structure in order to facilitate implementation of mitigation measures if... methodology in accordance with the Lookout Training Handbook (NAVEDTRA 12968-D). (F) After sunset and prior...

  8. 50 CFR 216.244 - Mitigation.

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    2010-10-01

    ... Training Handbook (NAVEDTRA, 12968-D). (iv) Lookout training shall include on-the-job instruction under the...). (v) Lookouts shall be trained in the most effective means to ensure quick and effective communication... Lookout Training Handbook (NAVEDTRA 12968-D). Surface lookouts should scan the water from the ship to...

  9. 50 CFR 216.174 - Mitigation.

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    2010-10-01

    ... Lookout Training Handbook (NAVEDTRA, 12968-D). (iv) Lookout training shall include on-the-job instruction... communication within the command structure in order to facilitate implementation of mitigation measures if... accordance with the Lookout Training Handbook (NAVEDTRA 12968-D). (xi) After sunset and prior to...

  10. 32 CFR 216.3 - Definitions.

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    2010-07-01

    ... associated with attendance). (c) Covered school. An institution of higher education, or a subelement of an... education that is part of a single university system (e.g., University of (State) at (City)—a part of that state's university system) has a policy or practice that prohibits, or in effect prevents, access...

  11. 24 CFR 1710.216 - Additional information.

    Science.gov (United States)

    2010-04-01

    ... a copy of the charter or certificate of incorporation. (2) If the developer exercises any control... of the United States, the Statement of Record shall be submitted in the English language and all... submitted in their original language and shall be accompanied by a translation into English....

  12. 40 CFR 21.6 - Exclusions.

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    2010-07-01

    ... for water pollution control. (5) Privately owned treatment facility service or user costs... transporting waste from a facility or site to any publicly owned sewer. (4) Other non-water related pollution... operated the water pollution control facility. This emission control equipment as an integral part of...

  13. 12 CFR 216.3 - Definitions.

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    2010-01-01

    ... 208.3(g); (2) A bank holding company, as defined in 12 CFR 225.2(c); (3) A subsidiary (as defined in 12 CFR 225.2(o)) or affiliate of a bank holding company and a subsidiary of a State member bank... section 4(k) of the Bank Holding Company Act of 1956 (12 U.S.C. 1843(k)). (2) Financial institution...

  14. 50 CFR 216.23 - Native exceptions.

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    2010-10-01

    ... to an Alaskan Native; or (iii) It is an edible portion and it is sold in an Alaskan Native village or... transformed into an authentic native article of handicraft or clothing; or (iv) It is an edible portion...

  15. 50 CFR 216.3 - Definitions.

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    2010-10-01

    ... to the labeling requirements of 50 CFR part 247 and that only contain fish harvested by vessels of... vessel operator's or vessel owner's control that could not be avoided by the exercise of due care. FSA... enrolled in the Metlaktla Indian Community), Eskimo, or Aleut blood or combination thereof. The...

  16. 20 CFR 216.2 - Definitions.

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    2010-04-01

    ... birth corresponding to such numerical age. Board means the Railroad Retirement Board. Claimant means an... filing of another application. Retirement age means, with respect to an employee who attains age 62...(er), or surviving divorced spouse) after December 31, 1999, retirement age means the age provided...

  17. 22 CFR 216.6 - Environmental assessments.

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    2010-04-01

    ... avoided should the proposed action be implemented; the relationship between short-term uses of the... significance; possible conflicts between the proposed action and land use plans, policies and controls for the... shall be governed by 22 CFR part 9. Those portions of an Environmental Assessment which are...

  18. 50 CFR 216.251 - Effective dates.

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    2010-10-01

    ..., DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS Taking Marine Mammals Incidental to Conducting Precision Strike Weapon Missions in the Gulf of Mexico §...

  19. 50 CFR 216.254 - Mitigation.

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    2010-10-01

    ..., DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS Taking Marine Mammals Incidental to Conducting Precision Strike Weapon Missions in the Gulf of Mexico §...

  20. 50 CFR 216.253 - Prohibitions.

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    2010-10-01

    ..., DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS Taking Marine Mammals Incidental to Conducting Precision Strike Weapon Missions in the Gulf of Mexico §...

  1. 8 CFR 216.2 - Notification requirements.

    Science.gov (United States)

    2010-01-01

    ... requirement that the alien and the petitioning spouse or alien entrepreneur must file a petition to remove the... petitioning spouse, or alien entrepreneur of the requirement to file a petition to remove conditions...

  2. Holmium laser lithotripsy for the treatment of urinary calculi: Report of 1216 cases%钬激光碎石术治疗泌尿系结石(附1 216例报告)

    Institute of Scientific and Technical Information of China (English)

    吴忠; 姜昊文; 张华魏; 陈智新; 历春军; 丁强; 张元芳

    2006-01-01

    目的探讨钬激光碎石术治疗泌尿系结石的疗效及其安全性. 方法应用输尿管肾镜和膀胱镜联合钬激光碎石术治疗1 216例泌尿系结石,其中输尿管结石1 006例(上段302例,中段364例,下段340例),膀胱结石210例. 结果1例输尿管上段结石因前列腺增生症致置镜困难改体外冲击波碎石(extracorporeal shock wave lithotripsy, ESWL)治疗.1 006例输尿管结石单次碎石成功率95.5%(961/1 006)),其中上、中、下段结石单次碎石成功率分别为89.4%(270/302)、96.4% (351/364)和100%(340/340),术中发生6例输尿管穿孔.膀胱结石单次碎石成功率为100%(210/210),无出血和膀胱穿孔发生.881例输尿管结石术后随访0.5~40个月,平均18.6月,输尿管上、中、下段结石排净率分别为91.1%(224/246)、98.5%(318/323)、100%(312/312 ),总结石排净率为96.9%(854/881);6例发生输尿管狭窄.187例膀胱结石术后随访0.5~31个月,平均12.4月,结石排净率98.4%(184/187). 结论钬激光碎石术治疗泌尿系结石疗高效、微创、安全,是输尿管结石和膀胱结石首选治疗方法.

  3. Stereotactic gamma knife radiosurgery for brain arteriovenous malformations (A Report of 216 Cases)%立体定向伽玛刀治疗脑动静脉畸型研究

    Institute of Scientific and Technical Information of China (English)

    梁军潮; 徐波涛; 王伟民; 赵刚; 吴鸿勋; 李林; 贺道华; 张聿浩

    2007-01-01

    Objective To evaluate the curative effect of stereotactic gamma knife radiosurgery on brain arteriovenous malformations (AVM).Methods Between July 1995 and May 1998,285 patients with cerebral AVM were treated with Leksell gamma knife,among which we collected the follow-up files of 216 cases fitting our demand,including 162 male and 54 female patients.The mean age of patients was 26.0 years (1.5~83 years).AVM volume ranged from 0.3 to 43.9 cm3 (the mean volume of Spetzler-Martin grading were as follows:grade I 42 cases,grade Ⅱ 68 cases,grade Ⅲ 95 cases,grade Ⅳ 7 cases,grade Ⅴ 4 cases.All the cases were followed up for 17~31 months.156 cases were oriented through conducting magnetic resonance angiography (MRA) with a 1.5 Tesla magnetic resonance system.Results The rates of obliteration and complications after stereotactic gamma knife radiosurgery were significantly related to the target volume,the Spetzlcr-Martin grade,the method of localization,the peripheral dosage and the quality control.The obliteration rate within two years was more than 78.5% in the patients with AVM≤5 cm3 in volume,Spetzler-Martin grade<Ⅲ in Spetzler-Martin grading system or peripheral dosage≥20Gy.4 cases had recurrent hemorrhage after the treatment and 9 cases had complications of obvious symptom of irradiated brain edema.Conclusions Stereotactic gamma knife radiosurgery is an effective and safe method for the brain AVM.There is a higher obliteration rate for AVM of grade Ⅰ-Ⅱ or the volume≤5.0 cm3 and the peripheral dosage≥20Gy.Accurate localization of the lesions by magnetic resonance angiography (MRA) combined with digital subtraction angiography (DSA) contributes to improve the obliteration rate and decrease the complications.%目的 评估伽玛刀(γ-刀)立体定向放射手术治疗脑动静脉畸形(AVM)的疗效;探讨脑AVM的γ-刀治疗定位方法.方法 用立体定向LekseⅡγ-刀放射外科治疗系统对216例脑AVM进行γ-刀立

  4. Molecular clouds and star formation toward the Galactic plane within 216.25° ≤ l ≤ 218.75° and -0.75° ≤ b ≤ 1.25°

    Science.gov (United States)

    Gong, Y.; Mao, R. Q.; Fang, M.; Zhang, S. B.; Su, Y.; Yang, J.; Jiang, Z. B.; Xu, Y.; Wang, M.; Wang, Y.; Lu, D. R.; Sun, J. X.

    2016-04-01

    Context. Molecular clouds trace the spiral arms of the Milky Way and all its star forming regions. Large-scale mapping of molecular clouds will provide an approach to understand the processes that govern star formation and molecular cloud evolution. Aims: As a part of the Milky Way Imaging Scroll Painting (MWISP) survey, the aim is to study the physical properties of molecular clouds and their associated star formation toward the Galactic plane within 216.25° ≤ l ≤ 218.75° and -0.75° ≤ b ≤ 1.25°, which covers the molecular cloud complex S287. Methods: Using the 3 × 3 Superconducting Spectroscopic Array Receiver (SSAR) at the PMO-13.7m telescope, we performed a simultaneous 12CO (1-0), 13CO (1-0), C18O (1-0) mapping toward molecular clouds in a region encompassing 3.75 square degrees. We also make use of archival data to study star formation within the molecular clouds. Results: We reveal three molecular clouds, the 15 km s-1 cloud, the 27 km s-1 cloud, and the 50 km s-1 cloud, in the surveyed region. The 50 km s-1 cloud is resolved with an angular resolution of ~1' for the first time. Investigating their morphology and velocity structures, we find that the 27 km s-1 cloud is likely affected by feedback from the stellar association Mon OB3 and the 50 km s-1 cloud is characterized by three large expanding molecular shells. The surveyed region is mapped in C18O (1-0) for the first time. We discover seven C18O clumps that are likely to form massive stars, and 15 dust clumps based on the Bolocam Galactic Plane Survey (BGPS) archive data. Using infrared color-color diagrams, we find 56 Class I and 107 Class II young stellar object (YSO) candidates toward a slightly larger region of 5.0 square degrees. Based on the distribution of YSO candidates, an overdensity is found around the HII region S287 and the intersection of two shells; this is probably indicative of triggering. The star formation efficiency (SFE) and rate (SFR) of the 27 km s-1 cloud are

  5. 49 CFR 571.216a - Standard No. 216a; Roof crush resistance; Upgraded standard.

    Science.gov (United States)

    2010-10-01

    ... weight of the added body structure). S7.2 Adjust the seats in accordance with S8.3.1 of 49 CFR 571.214... of 49 CFR 571.201. S7.3Orient the test device as shown in Figure 1 of this section, so that— (a) Its... seconds. S7.6Repeat the test on the other side of the vehicle. S8. Phase-in schedule for vehicles with...

  6. 49 CFR 571.216 - Standard No. 216; Roof crush resistance; Applicable unless a vehicle is certified to § 571.216a.

    Science.gov (United States)

    2010-10-01

    ... procedures of S7 until October 25, 2000. The option of using the test procedures of S8 ceases to be available.... S1. Scope. This standard establishes strength requirements for the passenger compartment roof. S2... into the occupant compartment in rollover crashes. S3. Application. (a) This standard applies...

  7. Dicty_cDB: VSD216 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available HSP's gapped (non-prelim): 0 length of query: 90 length of database: 80,480,566 effective... HSP length: 16 effective length of query: 74 effective length of database: 78,918,790 effective se...uery: 90 length of database: P,794,892,705 effective HSP length: 21 effective length of query: 69 effective ...length of database: P,261,936,330 effective search space: 2226073606770 effective search space used: 2226073...arch space: 5839990460 effective search space used: 5839990460 T: 0 A: 0 X1: 6 (11.9 bits) X2: 15 (29.7 bits

  8. 2.-16. VI on Ungaris Szombathely Kunstimajas...

    Index Scriptorium Estoniae

    2005-01-01

    Kristi Paabi, Kaire Ranniku, Ketli Tiitsari, Maria Valdma, Denes Farkasi ja Eemil Karila näitus "Luba kasvada suureks". Eksponeeritakse 30 ehet ja nende tegemisel lähtekohaks võetud fotosid, ühendatuna Eemil Karila ja Denes Farkasi 72 klaasanumast koosneva ruumiinstallatsiooniga

  9. 50 CFR 216.217 - Requirements for monitoring and reporting.

    Science.gov (United States)

    2010-10-01

    ..., and any other Federal, state or local agency with regulatory authority over the offshore oil-and-gas...) Acoustic surveys will be run concurrent with requisite pre-detonation surveys, beginning with the surface observations and concluding at the finish of the aerial surveys when the detonation(s) is allowed to...

  10. Dicty_cDB: CHO216 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available clone DKEY-181B17, genomic survey sequence. 34 0.035 2 AC110309 |AC110309.5 Ratt...library (AIAAGSS 001) Ancylostoma caninum genomic, genomic survey sequence. 34 0.13 2 CG726828 |CG726828.1 1...119091G10.y1 1119 - RescueMu Grid AA Zea mays genomic, genomic survey sequence. 3...4 0.13 2 CG721744 |CG721744.1 1119068G10.x1 1119 - RescueMu Grid AA Zea mays genomic, genomic survey sequenc...e. 34 0.13 2 CG731059 |CG731059.1 1119133A07.y1 1119 - RescueMu Grid AA Zea mays genomic, genomic survey seq

  11. 50 CFR 216.172 - Permissible methods of taking.

    Science.gov (United States)

    2010-10-01

    ... (Kogia sima)—10610 (an average of 2122 annually). (D) Cuvier's beaked whale (Ziphius cavirostris)—5750... Cuvier's beaked whale (Ziphius cavirostris), Blainville's beaked whale, (Mesoplodon...

  12. 50 CFR 216.165 - Requirements for monitoring and reporting.

    Science.gov (United States)

    2010-10-01

    ... IMPORTING OF MARINE MAMMALS Taking of Marine Mammals Incidental to Shock Testing the USS MESA VERDE (LPD 19... one who has graduated from a veterinary school accredited by the American Veterinary Medical... Response Program. Necropsies will be performed and tissue samples taken from any dead animals....

  13. 48 CFR 552.216-72 - Placement of Orders.

    Science.gov (United States)

    2010-10-01

    ... parties of certain electronic transaction conventions and to recognize the rights and responsibilities of..., the third party provider(s) through which electronic orders are placed, the transaction sets used... electronic transaction conventions and to recognize the rights and responsibilities of the parties as...

  14. 48 CFR 52.216-7 - Allowable Cost and Payment.

    Science.gov (United States)

    2010-10-01

    ... (CONTINUED) CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 52... written understanding setting forth the final indirect cost rates. The understanding shall specify (i) the... special terms and the applicable rates. The understanding shall not change any monetary ceiling,...

  15. 50 CFR 216.185 - Requirements for monitoring.

    Science.gov (United States)

    2010-10-01

    ... SURTASS LFA sonar transmission; (2) Continue between transmission pings; and (3) Continue either for at least 15 minutes after completion of the SURTASS LFA sonar transmission exercise, or, if marine mammals are exhibiting unusual changes in behavioral patterns, for a period of time until behavior...

  16. 50 CFR 216.234 - Mitigation, monitoring and reporting.

    Science.gov (United States)

    2010-10-01

    ... monitoring reports for that launch and year. If valuable data may be gathered using this method, real-time... Permits, Conservation, and Education, Office of Protected Resources at least 2 weeks prior to commencing... in the Letter of Authorization may be conducted without a separate scientific research permit. (h)...

  17. 48 CFR 1652.216-71 - Accounting and Allowable Cost.

    Science.gov (United States)

    2010-10-01

    ... MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION CLAUSES AND FORMS CONTRACT CLAUSES Texts.... Benefit costs consist of payments made and liabilities incurred for covered health care services on behalf... maintaining eligibility files, legal expenses incurred in the litigation of benefit payments and bank...

  18. 48 CFR 1552.216-78 - Award term incentive plan.

    Science.gov (United States)

    2010-10-01

    ... National Institutes of Health (NIH) Contractor Performance System (CPS) for this contract. The NIHCPS is an... evaluation of performance, and, together with Agency need and availability of funding, serves as the basis... ratings, for example: Criteria Rating Quality of Product or Service 5. Cost Control 4. Timeliness...

  19. 48 CFR 1552.216-77 - Award term incentive.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Award term incentive. 1552... Award term incentive. As prescribed in 1515.406(c), insert a clause substantially the same as follows: Award Term Incentive (FEB 2008) (a) General. This contract may be extended as set forth in paragraph...

  20. 50 CFR 216.242 - Permissible methods of taking.

    Science.gov (United States)

    2010-10-01

    ... annually). (G) Blue whale (Balaenoptera musculus)—4005 (an average of 801 annually). (ii) Odontocetes: (A... of 4202 annually). (C) Minke whale (Balaenoptera acutorostrata)—2075 (an average of 415 annually). (D) Sei whale (Balaenoptera borealis)—5285 (an average of 1057 annually). (E) Fin whale...

  1. 50 CFR 216.272 - Permissible methods of taking.

    Science.gov (United States)

    2010-10-01

    ... novaeangliae)—110 (an average of 22 annually) (B) Fin whale (Balaenoptera physalus)—870 (an average of 174 annually) (C) Blue whale (Balaenoptera musculus)—3085 (an average of 617 annually) (D) Minke whale (Balaenoptera acutorostrata)—665 (an average of 133 annually) (E) Gray whale (Eschrichtius robustus)—27340...

  2. 36 CFR 223.216 - Special Forest Products definitions.

    Science.gov (United States)

    2010-07-01

    ..., Christmas trees, cones, ferns, firewood, forbs, fungi (including mushrooms), grasses, mosses, nuts, pine..., derrick poles, minerals, animals, animal parts, insects, worms, rocks, water, and soil....

  3. 28 CFR 21.6 - Proceedings in forma pauperis.

    Science.gov (United States)

    2010-07-01

    ...) Civil cases. There are currently no provisions for payment of witnesses called by the indigent. If the indigent party prevails, witness fees and expenses may be taxed as costs in accordance with 28 U.S.C. 1920... subpoenaed on behalf of an indigent defendant be paid in the same manner as witnesses called on behalf of...

  4. Dicty_cDB: CHR216 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 8 1e-86 14 AX344559 |AX344559.1 Sequence 10 from Patent WO0200932. 34 8e-04 17 DD010735 |DD010735.1 Diagnosis of known genetic Parame...ters within the MHC. 36 0.004 17 AX344550 |AX344550.1 Se

  5. 50 CFR 216.175 - Requirements for monitoring and reporting.

    Science.gov (United States)

    2010-10-01

    ... ship (opening, closing, parallel). (N) Observed behavior—Watchstanders shall report, in plain language... plain language and without trying to categorize in any way, the observed behavior of the animal(s)...

  6. Education in Healthy Lifestyles: Curriculum Implications. Fastback 216.

    Science.gov (United States)

    Seffrin, John R.; Torabi, Mohammad R.

    The nature of a healthy lifestyle and its significance to quality of life is examined. Following a discussion on what is involved in a healthy lifestyle, major health problems are described: (1) smoking; (2) alcohol and drug abuse; (3) sexually transmitted diseases; (4) diet and obesity; (5) stress; and (6) inadequate sleep. Recommendations are…

  7. Dicty_cDB: AFH216 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available |BM260251.1 baa17f06.x1 Cassava EYC library1 Manihot esculenta cDNA 3' similar to...SC cDNA library Populus alba x Populus glandulosa cDNA clone PopSC00059, mRNA sequence. 46 1e-06 2 BM260251

  8. 50 CFR 216.125 - Requirements for monitoring and reporting.

    Science.gov (United States)

    2010-10-01

    ...-2289), within 48 hours of the discovery of the injured or dead animal. (b) Holders of Letters of... Letter of Authorization, to: (1) Conduct observations on harbor seal, elephant seal, and sea lion... surveys each day that surveys are required that record the species, number of animals, general...

  9. 48 CFR 352.216-70 - Additional cost principles.

    Science.gov (United States)

    2010-10-01

    ... needed to support the bids, proposals, and applications. (2) B & P costs of the current accounting period are allowable as indirect costs. (3) B & P costs of past accounting periods are unallowable in the current period. However, if the organization's established practice is to treat these costs by some...

  10. 48 CFR 3452.216-70 - Additional cost principles.

    Science.gov (United States)

    2010-10-01

    ... costs of the current accounting period are allowable as indirect costs; bid and proposal costs of past accounting periods are unallowable as costs of the current period. However, if the organization's established... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Additional cost...

  11. 48 CFR 852.216-70 - Estimated quantities.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Estimated quantities. 852... Estimated quantities. As prescribed in 816.504(a), insert the following clause: Estimated Quantities (APR... percent of the estimated requirement or which provide that the Government shall guarantee any...

  12. 48 CFR 1352.216-70 - Estimated and allowable costs.

    Science.gov (United States)

    2010-10-01

    ... Estimated and allowable costs. As prescribed in 48 CFR 1316.307(a), insert the following clause: Estimated and Allowable Costs (APR 2010) (a) Estimated Costs. The estimated cost of this contract is... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Estimated and...

  13. 48 CFR 52.216-25 - Contract Definitization.

    Science.gov (United States)

    2010-10-01

    ...) all clauses required by law on the date of execution of the definitive contract, and (3) any other... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Contract Definitization... (CONTINUED) CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses...

  14. 49 CFR 173.216 - Asbestos, blue, brown or white.

    Science.gov (United States)

    2010-10-01

    ... transportation and transported in— (1) Rigid, leaktight packagings, such as metal, plastic or fiber drums, portable tanks, hopper-type rail cars, or hopper-type motor vehicles; (2) Bags or other non-rigid packagings in closed freight containers, motor vehicles, or rail cars that are loaded by and for...

  15. 50 CFR 216.93 - Tracking and verification program.

    Science.gov (United States)

    2010-10-01

    ... Parties to the Agreement on the IDCP. (a) Tuna tracking forms. Whenever a U.S. flag tuna purse seine..., canning, sale, rejection, etc.). (4) During canning activities, non-dolphin-safe tuna may not be mixed...

  16. 27 CFR 40.216 - Notice for smokeless tobacco.

    Science.gov (United States)

    2010-04-01

    ... Notice for smokeless tobacco. (a) Product designation. Every package of chewing tobacco or snuff shall..., the designation “chewing tobacco” or “snuff.” As an alternative, packages of chewing tobacco may be designated “Tax Class C”, and packages of snuff may be designated “Tax Class M”. (b) Product weight....

  17. 22 CFR 216.2 - Applicability of procedures.

    Science.gov (United States)

    2010-04-01

    ...) 2220a. (1979)); (viii) Programs involving nutrition, health care or population and family planning... maternal or child feeding conducted under title II of Pub. L. 480; (xii) Food for development programs....2 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ENVIRONMENTAL PROCEDURES §...

  18. 22 CFR 1203.735-216 - Miscellaneous statutory provisions.

    Science.gov (United States)

    2010-04-01

    ... Government (18 U.S.C. 285). (15) The prohibition against political activities in subchapter III of chapter 73... (18 U.S.C. 219). (17) The prohibition against discrimination because of politics, race, religion,...

  19. 50 CFR 216.155 - Requirements for monitoring and reporting.

    Science.gov (United States)

    2010-10-01

    ...) Systematic visual observations, by those individuals, described in paragraph (c) of this section, on pinniped... monitoring measures: (1) Visual Land-Based Monitoring. (i) Prior to each missile launch, an observer(s) will... subpart. (5) Both the 60-day and final reports will be subject to review and comment by the...

  20. 50 CFR 216.275 - Requirements for monitoring and reporting.

    Science.gov (United States)

    2010-10-01

    ... adaptive management tool shall include: (1) A method for prioritizing monitoring projects that clearly...—indication of whale/dolphin/pinniped) (C) Number of individuals (D) Calves observed (y/n) (E) Initial...) Species (if not possible, indicate whale, dolphin or pinniped) (C) Number of individuals (D)...

  1. Dicty_cDB: CFK216 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available sllmkinselhqamkp*wklsri*kprttefqslkmkl ml*iyy*mksqkvlkscalavvplmksvsrkfisvmilhsst...sllmkinselhqamkp*wklsri*kprtte fqslkmklml*iyy*mksqkvlkscalavvplmksvsrkfisvmilhsstfikrf*lyql inklmlvkml*phntf

  2. 50 CFR 216.245 - Requirements for monitoring and reporting.

    Science.gov (United States)

    2010-10-01

    ... to categorize in any way, the observed behavior of the animals (such as animal closing to bow ride... explosive detonations. The Navy shall provide NMFS with species or description of the animal(s), the condition of the animal(s) (including carcass condition if the animal is dead), location, time of...

  3. 50 CFR 216.37 - Marine mammal parts.

    Science.gov (United States)

    2010-10-01

    ...: (1) The person transferring the part receives no remuneration of any kind for the marine mammal part... specifically authorized by the Regional Director, consistent with the requirements of paragraphs (a)(1) and (a... Regional Director of the transfer, including a description of the part, the person to whom the part...

  4. Dicty_cDB: SSD216 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SEQUENCE, 13 unordered pieces. 52 0.008 1 CD035209 |CD035209.1 mgmt019xA08f.b Ma...ted culture Magnaporthe grisea cDNA clone mgmt019xA08 5', mRNA sequence. 52 0.008 1 AF160643 |AF160643.2 D02

  5. 8 CFR 216.3 - Termination of conditional resident status.

    Science.gov (United States)

    2010-01-01

    ... of termination, the director shall issue a notice to appear in accordance with 8 CFR part 239. During..., whichever is applicable, are true, or it becomes known to the government that an alien entrepreneur who was... applicable, are true, or that an alien entrepreneur who was admitted pursuant to section 203(b)(5) of the...

  6. 24 CFR 884.216 - Termination of tenancy.

    Science.gov (United States)

    2010-04-01

    ... domestic violence, dating violence, stalking, or criminal activity directly related to domestic violence...). Failure of the family to sign and submit consent forms for the obtaining of wage and claim information from State Wage Information Collection Agencies, as provided by 24 CFR part 5, shall be grounds...

  7. An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE,CERN

    OpenAIRE

    Rothe, Sebastian

    2012-01-01

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spec...

  8. 19 CFR 10.216 - Maintenance of records and submission of Certificate by importer.

    Science.gov (United States)

    2010-04-01

    ..., quality, and reputation. (c) Correction and nonacceptance of Certificate. If the port director determines... importation of an article whose value does not exceed US$2,500, provided that, unless waived by the...

  9. 20 CFR 216.42 - How a private railroad pension affects a supplemental annuity.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false How a private railroad pension affects a... pension affects a supplemental annuity. (a) What is a private railroad pension. The Board determines whether a pension established by a railroad employer is a private pension that will cause a reduction...

  10. 75 FR 28319 - Thirteenth Meeting: EUROCAE WG-72: RTCA Special Committee 216: Aeronautical Systems Security...

    Science.gov (United States)

    2010-05-20

    .... FOR FURTHER INFORMATION CONTACT: RTCA Secretariat, 1828 L Street, NW., Suite 805, Washington, DC 20036; telephone (202) 833-9339; fax (202) 833-9434; Web site http://www.rtca.org . SUPPLEMENTARY INFORMATION...:15 to 11:30: Discuss collaboration and associated topics with other organisations (Arinc, DSWG,...

  11. 18 CFR 380.16 - Environmental reports for section 216 Federal Power Act Permits.

    Science.gov (United States)

    2010-04-01

    ... 0.5-mile-wide corridor centered on the electric transmission facility centerline, with integer... electronic installations, and airstrips. Older images/photographs/alignment sheets must be modified to show... mines, hazardous waste sites, wild and scenic rivers, designated trails, nature preserves,...

  12. 76 FR 50172 - Reorganization of Foreign-Trade Zone 216 Under Alternative Site Framework, Olympia, WA

    Science.gov (United States)

    2011-08-12

    ... Board adopted the alternative site framework (ASF) (74 FR 1170, 01/12/2009; correction 74 FR 3987, 01/22/2009; 75 FR 71069- 71070, 11/22/2010) as an option for the establishment or reorganization of general... (76 FR 27987, 05/13/2011) and the application has been processed pursuant to the FTZ Act and the...

  13. 26 CFR 1.216-2 - Treatment as property subject to depreciation.

    Science.gov (United States)

    2010-04-01

    ... corporation had used the straight line method of depreciation, in the absence of evidence establishing that... to such adjusted basis reduced by the amount of depreciation, computed under the straight line method... subject to the allowance for depreciation under section 167(a), and B, who uses the straight line......

  14. Yeast Interacting Proteins Database: YNL189W, YHR216W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available g, expression is repressed by nutrient limitation Rows with this prey as prey (1) Rows with this prey as bai...osynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limit

  15. 29 CFR 780.216 - Nursery activities generally and Christmas tree production.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Nursery activities generally and Christmas tree production... Nursery activities generally and Christmas tree production. (a) The employees of a nursery who are engaged... Christmas trees are considered to be agricultural or horticultural commodities. Employees engaged in...

  16. Length-weight relationships of 216 North Sea benthic invertebrates and fish

    NARCIS (Netherlands)

    Robinson, L.; Greenstreet, S.P.R.; Reiss, H.; Callaway, R.; Craeymeersch, J.A.M.; Boois, de I.J.

    2010-01-01

    Size-based analyses of marine animals are increasingly used to improve understanding of community structure and function. However, the resources required to record individual body weights for benthic animals, where the number of individuals can reach several thousand in a square metre, are often pro

  17. 10 CFR 1021.216 - Procurement, financial assistance, and joint ventures.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Procurement, financial assistance, and joint ventures... joint ventures. (a) This section applies to DOE competitive and limited-source procurements, to awards of financial assistance by a competitive process, and to joint ventures entered into as a result...

  18. 75 FR 16901 - Thirteenth Meeting: EUROCAE WG-72: RTCA Special Committee 216: Aeronautical Systems Security...

    Science.gov (United States)

    2010-04-02

    ...:15: Break. 11:15 to 11:30: Discuss collaboration and associated topics with other organisations... processes in relation to the planned releases for this year/early next--verify publication schedule....

  19. Hyperspectral Imagery for the Main Eight Hawaiian Islands:Oahu (216-0611-272217)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort among the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment; the...

  20. 216-Day report for Tank 241-C-111, cores 58 and 59

    International Nuclear Information System (INIS)

    Three core samples from tank C-111, and a field blank, were received by the 222-S laboratories. Cores 58, 59, and the field blank were analyzed in accordance with plans. A hot cell blank was analyzed at the direction of the hot cell chemist. No sample results exceeded the notification limits. Core 60 was not analyzed

  1. 49 CFR 216.11 - Special notice for repairs-railroad freight car.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Special notice for repairs-railroad freight car...—railroad freight car. (a) When an FRA Motive Power and Equipment Inspector or a State Equipment Inspector determines that a railroad freight car is not in conformity with the requirements of the FRA Freight...

  2. Yeast Interacting Proteins Database: YNL216W, YLR453C [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available nscription, depending on binding site context; also binds telomere sequences and plays a role in telomeric p...NA-binding protein involved in either activation or repression of transcription, depending on binding site context

  3. 12 CFR 216.5 - Annual privacy notice to customers required.

    Science.gov (United States)

    2010-01-01

    ... annually during the continuation of the customer relationship. Annually means at least once in any period...-month period, but you must apply it to the customer on a consistent basis. (2) Example. You provide a... notice to the customer once in each calendar year following the calendar year in which you provided...

  4. 20 CFR 216.62 - Who is eligible for an annuity as a surviving divorced spouse.

    Science.gov (United States)

    2010-04-01

    ...) Is not entitled to an old-age benefit under the Social Security Act that is equal to or higher than the surviving divorced spouse's annuity before any reduction for age; and either (3) Has attained... annuity.); (5) Is less than retirement age but has in his or her care a child who either is under age...

  5. 20 CFR 216.3 - Other regulations related to this part.

    Science.gov (United States)

    2010-04-01

    ... eligibility. Where eligibility for an annuity is based upon a family relationship to an employee (for example, a widow's annuity), the definition of such family relationship may be found in part 222 of...

  6. 14 CFR 21.6 - Manufacture of new aircraft, aircraft engines, and propellers.

    Science.gov (United States)

    2010-01-01

    ... Manufacture of new aircraft, aircraft engines, and propellers. (a) Except as specified in paragraphs (b) and (c) of this section, no person may manufacture a new aircraft, aircraft engine, or propeller based on... provisions of §§ 21.183(c), 21.184(b), or 21.185(c); and (2) New aircraft engines or propellers...

  7. 50 CFR 216.270 - Specified activity and specified geographical region.

    Science.gov (United States)

    2010-10-01

    ... pings per dip) (v) SSQ-62 (Directional Command Activated Sonobuoy System (DICASS) sonobuoys)—up to 21275 sonobuoys over the course of 5 years (an average of 4255 sonobuoys per year) (vi) MK-48 (heavyweight... average of 227 hours per year) (x) AN/SSQ-125 (AEER sonar sonobuoy)—up to 540 sonobuoys (total, of...

  8. 50 CFR 216.170 - Specified activity and specified geographical region.

    Science.gov (United States)

    2010-10-01

    ... year) (iv) SSQ-62 (sonobuoys)—up to 12115 sonobuoys over the course of 5 years (an average of 2423 sonobuoys per year) (v) MK-48 (torpedoes)—up to 1565 torpedoes over the course of 5 years (an average of...

  9. 50 CFR 216.240 - Specified activity and specified geographical region.

    Science.gov (United States)

    2010-10-01

    ... (MFAS) sources, high frequency active sonar (HFAS) sources, or explosive sonobuoys for U.S. Navy anti...) SSQ-62 (Directional Command Activated Sonobuoy System (DICASS) sonobuoys)—up to 29265 sonobuoys over the course of 5 years (an average of 5853 sonobuoys per year). (7) MK-48 (heavyweight torpedoes)—up...

  10. 20 CFR 216.51 - Who is eligible for a spouse annuity.

    Science.gov (United States)

    2010-04-01

    ...: (1) Retirement age or older; (2) Less than retirement age and have in his or her care a disabled... old if the spouse claimant is a husband) of the employee; or (3) Age 62 or older but under retirement age. In such case, all annuity components are reduced for each month the spouse is under...

  11. 20 CFR 216.31 - Who is eligible for an age annuity.

    Science.gov (United States)

    2010-04-01

    ... Retirement Act provides annuities based on the employee's age for employees who have been credited with at...) Has attained retirement age; or (2) Has attained age 62 (the annuity cannot begin prior to the first full month during which the employee is age 62) but is less than retirement age. All components of...

  12. 20 CFR 216.61 - Who is eligible for an annuity as a widow(er).

    Science.gov (United States)

    2010-04-01

    ... eligible for an annuity if he or she: (1) Has not remarried; and either (2) Has attained retirement age; (3... less than retirement age but has in his or her care a child who either is under age 18 (16 with respect... part; or (5) Is at least 60 years of age but has not attained retirement age. (In this case,...

  13. W-026 acceptance test plan plant control system hardware (submittal {number_sign} 216)

    Energy Technology Data Exchange (ETDEWEB)

    Watson, T.L., Fluor Daniel Hanford

    1997-02-14

    Acceptance Testing of the WRAP 1 Plant Control System Hardware will be conducted throughout the construction of WRAP I with the final testing on the Process Area hardware being completed in November 1996. The hardware tests will be broken out by the following functional areas; Local Control Units, Operator Control Stations in the WRAP Control Room, DMS Server, PCS Server, Operator Interface Units, printers, DNS terminals, WRAP Local Area Network/Communications, and bar code equipment. This document will contain completed copies of each of the hardware tests along with the applicable test logs and completed test exception reports.

  14. 42 CFR 457.216 - Treatment of uncashed or canceled (voided) CHIP checks.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Treatment of uncashed or canceled (voided) CHIP... canceled (voided) CHIP checks. (a) Purpose. This section provides rules to ensure that States refund the... section— Canceled (voided) check means an CHIP check issued by a State or fiscal agent that prior to...

  15. 29 CFR 1910.216 - Mills and calenders in the rubber and plastics industries.

    Science.gov (United States)

    2010-07-01

    ... in accordance with this section and Subpart S of this part. (4) Mill roll heights. All new mill...) Mill safety controls—(1) Safety trip control. A safety trip control shall be provided in front and in back of each mill. It shall be accessible and shall operate readily on contact. The safety trip...

  16. 42 CFR 57.216 - What additional Department regulations apply to schools?

    Science.gov (United States)

    2010-10-01

    ...—Nondiscrimination on the basis of sex in education programs and activities receiving or benefiting from Federal... limited to: 45 CFR part 76—Governmentwide Debarment and Suspension (nonprocurement) and Governmentwide Requirements for Drug-Free Workplace (Grants) 45 CFR part 80—Nondiscrimination under programs receiving...

  17. 26 CFR 1.216-1 - Amounts representing taxes and interest paid to cooperative housing corporation.

    Science.gov (United States)

    2010-04-01

    ... the name, address, and taxpayer identification number of the cooperative housing corporation, identify... donor in an amount equal to the portion of the fair market value, as of the date of the...

  18. 48 CFR 1552.216-79 - Award term availability of funds.

    Science.gov (United States)

    2010-10-01

    ... Government's obligation under any award term is contingent upon the availability of appropriated funds from which payment can be made. No legal liability on the part of the Government for any award term...

  19. 7 CFR 2.16 - Under Secretary for Farm and Foreign Agricultural Services.

    Science.gov (United States)

    2010-01-01

    ... pursuant thereto by the Attorney General and the Comptroller General (4 CFR chapter II), with respect to.... 2008j), relating to the National Sheep Industry Improvement Center. (3) Related to foreign agriculture...) Conduct economic analyses pertaining to the foreign sugar situation. (xxi) Exercise the...

  20. 48 CFR 1852.216-87 - Submission of vouchers for payment.

    Science.gov (United States)

    2010-10-01

    ... original voucher should be submitted to: (2) For any period that the Defense Contract Audit Agency has... payment, subject to final audit. (3) Copies of vouchers should be submitted as directed by the Contracting...) Public vouchers for payment of fee shall be prepared similarly to the procedures in paragraphs (b) or...

  1. Compound list: simvastatin [Open TG-GATEs

    Lifescience Database Archive (English)

    Full Text Available simvastatin SST 00117 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/simv...astatin.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/simv...astatin.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/simv...archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/simvastatin.Rat.in_vivo.Liver.Repeat.zip ...

  2. 5 CFR 551.216 - Law enforcement activities and 7(k) coverage for FLSA pay and exemption determinations.

    Science.gov (United States)

    2010-01-01

    ... customs examining or inspecting; mine safety and health examining or inspecting; alcohol, tobacco and... persons or organizations seeking, claiming or receiving Federal benefits, permits, or employment...

  3. 50 CFR 216.24 - Taking and related acts incidental to commercial fishing operations by tuna purse seine vessels...

    Science.gov (United States)

    2010-10-01

    ... an observer, or to harass (including sexual harassment) an observer by conduct that has the purpose... governing permit sanctions and denials are found at subpart D of 15 CFR part 904. (ii) Observer placement... experimental fishing waiver in accordance with 15 CFR part 904 if the terms and conditions of the waiver or...

  4. 8 CFR 216.5 - Waiver of requirement to file joint petition to remove conditions by alien spouse.

    Science.gov (United States)

    2010-01-01

    ... the field. An evaluation which was obtained in the course of the divorce proceedings may be submitted.... If the decision is adverse, the director shall advise the alien of the reasons therefor, notify...

  5. SU-E-J-216: A Sequence Independent Approach for Quantification of MR Image Deformations From Brachytherapy Applicators

    Energy Technology Data Exchange (ETDEWEB)

    Wieringen, N van; Heerden, L van; Gurney-Champion, O; Kesteren, Z van; Houweling, A; Pieters, B; Bel, A [Academic Medical Center, Amsterdam (Netherlands)

    2015-06-15

    Purpose: MRI is increasingly used as a single imaging modality for brachytherapy treatment planning. The presence of a brachytherapy applicator may cause distortions in the images, especially at higher field strengths. Our aim is to develop a procedure to quantify these distortions theoretically for any MR-sequence and to verify the estimated deformations for clinical sequences. Methods: Image distortions due to perturbation of the B0-field are proportional to the ratio of the induced frequency shift and the read-out bandwidth of the applied sequence. By reconstructing a frequency-shift map from the phase data from a multi-echo sequence, distortions can be calculated for any MR-sequence. Verification of this method for estimating distortions was performed by acquiring images with opposing read-out directions and consequently opposing distortions. The applicator shift can be determined by rigidly matching these images. Clinically, T2W-TSE-images are used for this purpose. For pre-clinical tests, EPI-sequences with narrow read-out bandwidth (19.5–47.5Hz), consequently large distortions, were added to the set of clinical MRsequences. To quantify deformations of the Utrecht Interstitial CT/MR applicator (Elekta Brachytherapy) on a Philips Ingenia 3T MRI, pre-clinical tests were performed in a phantom with the applicator in water, followed by clinical validation. Results: Deformations observed in the narrow bandwidth EPI-images were well predicted using the frequency-shift, the latter giving an overestimation up to 30%/up to 1 voxel. For clinically applied MR-sequences distortions were well below the voxel size. In patient setup distortions determined from the frequency-shift map were at sub-voxel level (<0.7mm). Using T2W-images larger distortions were found (1–2mm). This discrepancy was caused by patient movement between/during acquisition of the T2W-images with opposing read-out directions. Conclusion: Phantom experiments demonstrated the feasibility of a clinical procedure for quantification of MR-image distortions for any MR-sequence. In a clinical set-up the distortions from a Utrecht interstitial CT/MR applicator are sub-voxel level. This work was partially funded by Elekta Brachytherpy.

  6. 77 FR 28568 - Foreign-Trade Zone 216-Olympia, WA; Notification of Proposed Production Activity; Callisons, Inc...

    Science.gov (United States)

    2012-05-15

    ... essential oils of peppermint (mentha piperita), other essential mint oils, odoriferous mixtures for use by..., cyclenic ethers and derivatives, cyclenic ketones without oxygen, essential oils of peppermint...

  7. 77 FR 29683 - Outer Continental Shelf (OCS) Consolidated Central Gulf of Mexico Planning Area Sale; 216/222

    Science.gov (United States)

    2012-05-18

    ... Mexico are specified as (1) less than 800 meters and (2) 800 meters or more. Per 64 FR 37560, if....gov . This requirement was implemented on October 1, 2003, and requires all entities doing business... Bureau of Ocean Energy Management Outer Continental Shelf (OCS) Consolidated Central Gulf of...

  8. 77 FR 56611 - Foreign-Trade Zone 216-Olympia, WA; Authorization of Production Activity; Callisons, Inc. (Mint...

    Science.gov (United States)

    2012-09-13

    ...), including notice in the Federal Register inviting public comment (77 FR 28568, 5-15-2012). The FTZ Board has...; Callisons, Inc. (Mint Products); Lacey and Chehalis, WA On May 10, 2012, the Port of Olympia, grantee of...

  9. 20 CFR 216.63 - Who is eligible for an annuity as a remarried widow(er).

    Science.gov (United States)

    2010-04-01

    ...: (i) After having attained age 60 (after age 50 if disabled); or (ii) Before age 60 but the marriage terminated; (2) Is not entitled to an old-age benefit under the Social Security Act that is equal to or... reduced annuity); (5) Has not attained retirement age but has in his or her care a child who either...

  10. VizieR Online Data Catalog: ExoMol line lists for H216O2 (Al-Refaie+, 2016)

    Science.gov (United States)

    Al-Refaie, A. F.; Polyansky, O. L.; Tennyson, J.; Yurchenko, S. N.

    2016-06-01

    The data are in two parts. The first, h2o20-85.dat contains a list of 7,560,352 rovibrational states. Each state is labelled with: six normal mode vibrational quantum numbers the torsional symmetry number (tau) and the vibrational symmetry; three rotational quantum numbers including the total angular momentum J and rotational symmetry; the total symmetry quantum number Gamma and the running number in the same J,Gamma block. In addition there are six local mode vibrational numbers and the largest coefficient used to assign the state in question. Each rovibrational state has a unique number, which is the number of the row in which it appears in the file. This number is the means by which the state is related to the second part of the data system, the transitions files. The total degeneracy is also given to facilitate the intensity calculations. Because of their size, the transitions are listed in 60 separate files, each containing all the transitions in a 100cm-1 frequency range. These and their contents are ordered by increasing frequency. The name of the file includes the lowest frequency in the range; thus the a-0500.dat file contains all the transitions in the frequency range 500-600cm-1. The transition files contain three columns: the reference number in the energy file of the upper state; that of the lower state; and the Einstein A coefficient of the transition. The energy file and the transitions files are zipped, and need to be extracted before use. There is a Fortran 90 programme, s_APTY.f90 which may be used to generate synthetic spectra (see s_APTY.txt for details). Using this, it is possible to generate absorption or emission spectra in either 'stick' form or else cross-sections convoluted with a gaussian with the half-width at half maximum being specified by the user, or with a the temperature-dependent doppler half-width. Sample input files s*.inp for use with sAPTY.f90 are supplied. (10 data files).

  11. Oahu Hyperspectral Imagery 2000 (216-0611-272217) - Visual Interpretation from Remote Sensing Imagery Main Eight Hawaiian Islands

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort between the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment,...

  12. Oahu Hyperspectral Imagery 2000 (216-0611-332211) - Visual Interpretation from Remote Sensing Imagery Main Eight Hawaiian Islands

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort between the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment,...

  13. P2-16: Dual-Bound Model and the Role of Time Bound in Perceptual Decision Making

    Directory of Open Access Journals (Sweden)

    Daeseob Lim

    2012-10-01

    Full Text Available The diffusion model (DM encapsulates the dynamics of perceptual decision within a ‘diffusion field’ that is defined by a basis with sensory-evidence (SE and time vectors. At the core of the DM, it assumes that a decision is not made until an evidence particle drifts in the diffusion field and eventually hits one of the two pre-fixed bounds defined in the SE axis. This assumption dictates when and which choice is made by referring to when and which bound will be hit by the evidence particle. What if urgency pressures the decision system to make a choice even when the evidence particle has yet hit the SE bound? Previous modeling attempts at coping with time pressure, despite differences in detail, all manipulated the coordinate of SE bounds. Here, we offer a novel solution by adopting another bound on the time axis. This ‘dual-bound’ model (DBM posits that decisions can also be made when the evidence particle hits a time bound, which is determined on a trial-by-trial basis by a ‘perceived time interval’ – how long the system can stay in the ‘diffusion’ field. The classic single-bound model (SBM exhibited systematic errors in predicting both the reaction time distributions and the time-varying bias in choice. Those errors were not corrected by previously proposed variants of the SBM until the time bound was introduced. The validity of the DBM was further supported by the strong across-individual correlation between observed precision of interval timing and the predicted trial-by-trial variability of the time bound.

  14. 8 CFR 216.6 - Petition by entrepreneur to remove conditional basis of lawful permanent resident status.

    Science.gov (United States)

    2010-01-01

    ... full-time jobs for qualifying employees. In the case of a “troubled business” as defined in 8 CFR 204.6... qualifying employees. In the case of a “troubled business” as defined in 8 CFR 204.6(j)(4)(ii), the alien... issue an order to show cause why the alien should not be deported from the United States. The...

  15. 21 CFR 216.24 - Drug products withdrawn or removed from the market for reasons of safety or effectiveness.

    Science.gov (United States)

    2010-04-01

    .... Bromfenac sodium: All drug products containing bromfenac sodium. Butamben: All parenteral drug products containing butamben. Camphorated oil: All drug products containing camphorated oil. Carbetapentane citrate: All oral gel drug products containing carbetapentane citrate. Casein, iodinated: All drug...

  16. SU-E-J-216: A Sequence Independent Approach for Quantification of MR Image Deformations From Brachytherapy Applicators

    International Nuclear Information System (INIS)

    Purpose: MRI is increasingly used as a single imaging modality for brachytherapy treatment planning. The presence of a brachytherapy applicator may cause distortions in the images, especially at higher field strengths. Our aim is to develop a procedure to quantify these distortions theoretically for any MR-sequence and to verify the estimated deformations for clinical sequences. Methods: Image distortions due to perturbation of the B0-field are proportional to the ratio of the induced frequency shift and the read-out bandwidth of the applied sequence. By reconstructing a frequency-shift map from the phase data from a multi-echo sequence, distortions can be calculated for any MR-sequence. Verification of this method for estimating distortions was performed by acquiring images with opposing read-out directions and consequently opposing distortions. The applicator shift can be determined by rigidly matching these images. Clinically, T2W-TSE-images are used for this purpose. For pre-clinical tests, EPI-sequences with narrow read-out bandwidth (19.5–47.5Hz), consequently large distortions, were added to the set of clinical MRsequences. To quantify deformations of the Utrecht Interstitial CT/MR applicator (Elekta Brachytherapy) on a Philips Ingenia 3T MRI, pre-clinical tests were performed in a phantom with the applicator in water, followed by clinical validation. Results: Deformations observed in the narrow bandwidth EPI-images were well predicted using the frequency-shift, the latter giving an overestimation up to 30%/up to 1 voxel. For clinically applied MR-sequences distortions were well below the voxel size. In patient setup distortions determined from the frequency-shift map were at sub-voxel level (<0.7mm). Using T2W-images larger distortions were found (1–2mm). This discrepancy was caused by patient movement between/during acquisition of the T2W-images with opposing read-out directions. Conclusion: Phantom experiments demonstrated the feasibility of a clinical procedure for quantification of MR-image distortions for any MR-sequence. In a clinical set-up the distortions from a Utrecht interstitial CT/MR applicator are sub-voxel level. This work was partially funded by Elekta Brachytherpy

  17. 8 CFR 216.4 - Joint petition to remove conditional basis of lawful permanent resident status for alien spouse.

    Science.gov (United States)

    2010-01-01

    ... of the marriage through annulment, divorce, or the death of the petitioning spouse, or if the... arrange for the affiants to be present at the interview, at no expense to the government. Once the.... Form I-751 shall be accompanied by evidence that the marriage was not entered into for the purpose...

  18. Three-Dimensional Modeling of DNAPL in the Subsurface of the 216-Z-9 Trench at the Hanford Site

    Energy Technology Data Exchange (ETDEWEB)

    Oostrom, Mart; Rockhold, Mark L.; Thorne, Paul D.; Last, George V.; Truex, Michael J.

    2004-11-02

    This work describes numerical modeling for simulating carbon tetrachloride flow and transport as outlined in two DOE reports for the 200-PW-1 Operable Unit and the 200-PW-1, 200-PW-3, and 200-PW-6 Operable Units. Simulations using the multifluid flow model STOMP were conducted to estimate how disposed dense nonaqueous phase liquid migrates in the vadose zone.

  19. BPC216全自动生化分析仪速率法检测血清CK-MB酶海力

    Institute of Scientific and Technical Information of China (English)

    詹伦琴

    1994-01-01

    肌酸激酶(Creatine Kinase,CK)是由B和M两条亚基组成的二聚体,有三种同工酶。存在于脑和前列腺等非肌组织者为CK-BB,存在于骨骼肌及心肌中为CK-MM,心肌除以CK-MM型为主外,尚有CK-MB型。正常血清中绝大部分为CK-MM型,

  20. Selected papers, in: Modern Aspects of the Theory of Partial Differential Equations, M. Ruzhansky, J. Wirth (Eds); Operator Theory: Advances and Applications, Vol. 216, 367 pp.

    OpenAIRE

    Bucci, Francesca; Lasiecka, Irena

    2011-01-01

    The book provides a quick overview of a wide range of active research areas in partial differential equations such as evolution equations and estimates for their solutions, control theory, inverse problems, nonlinear equations, elliptic theory on singular domains, numerical approaches. It will serve as a useful source of information to mathematicians, scientists and engineers.

  1. Single-Molecule Spectroscopy Reveals that Individual Low-Light LH2 Complexes from Rhodopseudomonas palustris 2.1.6. Have a Heterogeneous Polypeptide Composition

    Science.gov (United States)

    Brotosudarmo, Tatas H.P.; Kunz, Ralf; Böhm, Paul; Gardiner, Alastair T.; Moulisová, Vladimíra; Cogdell, Richard J.; Köhler, Jürgen

    2009-01-01

    Abstract Rhodopseudomonas palustris belongs to the group of purple bacteria that have the ability to produce LH2 complexes with unusual absorption spectra when they are grown at low-light intensity. This ability is often related to the presence of multiple genes encoding the antenna apoproteins. Here we report, for the first time to our knowledge, direct evidence that individual low-light LH2 complexes have a heterogeneous αβ-apoprotein composition that modulates the site energies of Bchl a molecules, producing absorption bands at 800, 820, and 850 nm. The arrangement of the Bchl a molecules in the “tightly coupled ring” can be modeled by nine αβ-Bchls dimers, such that the Bchls bound to six αβ-pairs have B820-like site energies and the remaining Bchl a molecules have B850-like site energies. Furthermore, the experimental data can only be satisfactorily modeled when these six αβ-pairs with B820 Bchl a molecules are distributed such that the symmetry of the assembly is reduced to C3. It is also clear from the measured single-molecule spectra that the energies of the electronically excited states in the mixed B820/850 ring are mainly influenced by diagonal disorder. PMID:19720038

  2. Airborne in situ vertical profiling of HDO / H216O in the subtropical troposphere during the MUSICA remote sensing validation campaign

    Science.gov (United States)

    Dyroff, C.; Sanati, S.; Christner, E.; Zahn, A.; Balzer, M.; Bouquet, H.; McManus, J. B.; Gonzalez-Ramos, Y.; Schneider, M.

    2015-05-01

    Vertical profiles of water vapor (H2O) and its isotope ratio D / H expressed as δD(H2O) were measured in situ by the ISOWAT II diode-laser spectrometer during the MUlti-platform remote Sensing of Isotopologues for investigating the Cycle of Atmospheric water (MUSICA) airborne campaign. We present recent modifications of the instrument design. The instrument calibration on the ground as well as in flight is described. Based on the calibration measurements, the humidity-dependent uncertainty of our airborne data is determined. For the majority of the airborne data we achieved an accuracy (uncertainty of the mean) of Δ(δD) ≈10‰. Vertical profiles between 150 and ~7000 m were obtained during 7 days in July and August 2013 over the subtropical North Atlantic Ocean near Tenerife. The flights were coordinated with ground-based (Network for the Detection of Atmospheric Composition Change, NDACC) and space-based (Infrared Atmospheric Sounding Interferometer, IASI) FTIR remote sensing measurements of δD(H2O) as a means to validate the remote sensing humidity and δD(H2O) data products. The results of the validation are presented in detail in a separate paper (Schneider et al., 2014). The profiles were obtained with a high vertical resolution of around 3 m. By analyzing humidity and δD(H2O) correlations we were able to identify different layers of air masses with specific isotopic signatures. The results are discussed.

  3. 7 CFR 1.216 - Appearance as a witness or production of documents on behalf of a party other than the United...

    Science.gov (United States)

    2010-01-01

    ..., subpoena, compulsory process, or to deny authorization under paragraph (b)(2) of this section. (d) As... employee of USDA served with a valid summons, subpoena, or other compulsory process demanding his or her... valid summons, subpoena, or other compulsory process issued by a court, administrative agency, or...

  4. The Mycoplasma hominis P120 membrane protein contains a 216 amino acid hypervariable domain that is recognized by the human humoral immune response

    DEFF Research Database (Denmark)

    Nyvold, Charlotte Guldborg; Birkelund, Svend; Christiansen, Gunna

    1997-01-01

    In the antigenically heterogeneous species Mycoplasma hominis a monoclonal antibody, mAb 26.7D, was previously found to recognize a 120 kDa polypeptide from M. hominis 7488. This antibody did not react with the type strain PG21. The homologous gene from M. hominis PG21 was cloned and sequenced...... with the 7488 hypervariable fusion protein, but only four reacted with PG21 hypervariable fusion protein. No reactivity was seen with a fusion protein containing part of the constant region of P120. Gene fragments amplified from 18 M. hominis isolates by PCR confirmed the heterogeneity of the hypervariable...... domain. Based on restriction endonuclease cleavage patterns of the hypervariable domain the 18 isolates could be divided into four cases. Reactivity with both mAb 26.7D and pAb 121 confirmed these classes. The hypervariable, but not the constant, part of P120 was recognized by the human humoral immune...

  5. SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995

    Energy Technology Data Exchange (ETDEWEB)

    Jaszczak, R.J.

    1995-12-01

    Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed tomography (SPECT) quantification of iodine 123 and astatine 211; and the development and evaluation of SPECT pinhole imaging for low and medium energy photons.

  6. Shelf-life of ɛ-lysyl-3-(trimethylstannyl)benzamide immunoconjugates, precursors for 211At labeling of antibodies

    DEFF Research Database (Denmark)

    Aneheim, Emma; Halleröd, Jenny; Albertsson, Per;

    2015-01-01

    Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it comes to the treatment of occult disseminated cancer. Preclinical research has proven effective, and patient studies have been initiated based on these results. However, a lack of production capacity...

  7. 10 CFR Appendix B to Part 20 - Annual Limits on Intake (ALIs) and Derived Air Concentrations (DACs) of Radionuclides for...

    Science.gov (United States)

    2010-01-01

    .... Actinium Ac 89 Aluminum Al 13 Americium Am 95 Antimony Sb 51 Argon Ar 18 Arsenic As 33 Astatine At 85... Curium Cm 96 Dysprosium Dy 66 Einsteinium Es 99 Erbium Er 68 Europium Eu 63 Fermium Fm 100 Fluorine F...

  8. SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995

    International Nuclear Information System (INIS)

    Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed tomography (SPECT) quantification of iodine 123 and astatine 211; and the development and evaluation of SPECT pinhole imaging for low and medium energy photons

  9. Hurdles for a Broader Use of 211At and for the Synthesis of 211At-Labelled Radiopharmaceuticals at High Activities for Clinical Use

    International Nuclear Information System (INIS)

    One of the key impediments to the use of 211At is the very well known deleterious effect of high radiation fields caused by its alpha particles on the synthesis of 211At-labelled radiopharmaceuticals. This is problematic because radiolysis-mediated effects can produce diminishing efficiency of electrophilic astatination reactions due to increasing deposition of radiation dose with increasing activities and with the passage of the time. Astatine-211 has chemical properties that permit complex labelling strategies and a longer half-life than 213Bi that makes it more suitable when the targeting molecule does not gain immediate access to the tumour cells. The first clinical evaluation was published in 2001 [2] in patients with brain tumour. Although this study circumvents many of the challenges to entering clinical studies with 211At and many obstacles had to be surmounted before clinical studies could be initiated, several problems were encountered in maintaining efficient labelling with escalating radiation dose of α-particle even with fresh 211At elution [3]. Astatine-211 also has an additional hurdle to overcome before to its clinical application in labelled radiopharmaceuticals related with its production and distribution. Among the potential group of promising α- emitter it is the only one produced by cyclotrons, but due to the scarcity of cyclotrons equipped with 25−30 MeV α-particle beams, it will of necessity be utilized in distant locations from the site of production. It presents a major chemical challenge because the diminishing efficiency of electrophilic astatination reactions with the passage of the time is well known, a problem likely related to the radiolysis produced by the high LET (linear energy transfer) meaning that large amounts of energy are deposited in a highly localized manner. This problem has been most comprehensively investigated to understand and evaluate the role of the radiolysis effects of astatine alpha particles in the synthesis

  10. Dicty_cDB: SLC575 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available U034586 ) Dictyostelium discoideum slug cDNA, clone SLC575. 216 8e-54 2 ( AU053333 ) Dictyostelium discoideum slug... cDNA, clone SLI409. 216 1e-53 2 ( AU038601 ) Dictyostelium discoideum slug... cDNA, clone SSL233. 216 1e-53 2 ( AU052355 ) Dictyostelium discoideum slug cDNA, clone SLD187. 216 2e-53 2 ...( AU053301 ) Dictyostelium discoideum slug cDNA, clone SLI347. 216 2e-53 2 ( AU039583 ) Dictyostelium discoideum slug... cDNA, clone SLE787. 216 2e-53 2 ( AU062090 ) Dictyostelium discoideum slug cDNA, clone SLH520. 216

  11. $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with radioactive At beams

    CERN Multimedia

    We propose to study the $\\beta$-delayed fission, laser spectroscopy and radioactive decay of the newly available pure beams of neutron-deficient and neutron-rich astatine (Z=85) isotopes. The fission probability and the fission fragment distribution of the even-even isotopes $^{194,196}$Po following the $\\beta$-decay of the isotopes $^{194,196}$At will be studied with the Windmill setup. In-source laser spectroscopy will be performed on the entire astatine isotopic chain, using a combination of the Windmill setup, ISOLTRAP MR-ToF and ISOLDE Faraday. Radioactive decay data will be acquired at the Windmill setup throughout those studies and contribute to the global understanding of the phenomenon of shape coexistence in the neutron-deficient lead region.

  12. Production cross section of At radionuclides from $^{7}$Li+$^{\\textrm{nat}}$Pb and $^{9}$Be+$^{\\textrm{nat}}$Tl reactions

    CERN Document Server

    Maiti, Moumita

    2011-01-01

    Earlier we reported theoretical studies on the probable production of astatine radionuclides from $^{6,7}$Li and $^{9}$Be-induced reactions on natural lead and thalliun targets, respectively. For the first time, in this report, production of astatine radionuclides has been investigated experimentally with two heavy ion induced reactions: $^{9}$Be+$^{\\textrm{nat}}$Tl and $^{7}$Li+$^{\\textrm{nat}}$Pb. Formation cross sections of the evaporation residues, $^{207,208,209,210}$At, produced in (HI, xn) channel, have been measured by the stacked-foil technique followed by the off-line $\\gamma$-spectrometry at the low incident energies ($<$50 MeV). Measured excitation functions have been explained in terms of compound nuclear reaction mechanism using Weisskopf-Ewing and Hauser-Feshbach model. Absolute cross section values are lower than the respective theoretical predictions.

  13. Early detection of response to experimental chemotherapeutic Top216 with [18F]FLT and [18F]FDG PET in human ovary cancer xenografts in mice

    DEFF Research Database (Denmark)

    Jensen, Mette Munk; Erichsen, Kamille Dumong; Björkling, Fredrik;

    2010-01-01

    3'-Deoxy-3'-[(18)F]fluorothymidine ((18)F-FLT) is a tracer used to assess cell proliferation in vivo. The aim of the study was to use (18)F-FLT positron emission tomography (PET) to study treatment responses to a new anti-cancer compound. To do so, we studied early anti-proliferative effects of t...

  14. Hyperspectral surface materials map of quadrangles 3668 and 3768, Baghlan (221), Taluqan (222), Imam Sahib (215), and Rustaq (216) quadrangles, Afghanistan, showing iron-bearing minerals and other materials

    Science.gov (United States)

    King, Trude V.V.; Hoefen, Todd M.; Kokaly, Raymond F.; Livo, Keith E.; Johnson, Michaela R.; Giles, Stuart A.

    2013-01-01

    This map shows the spatial distribution of selected iron-bearing minerals and other materials derived from analysis of airborne HyMap™ imaging spectrometer (hyperspectral) data of Afghanistan collected in late 2007. This map is one in a series of U.S. Geological Survey/Afghanistan Geological Survey quadrangle maps covering Afghanistan. Flown at an altitude of 50,000 feet (15,240 meters (m)), the HyMap™ imaging spectrometer measured reflected sunlight in 128 channels, covering wavelengths between 0.4 and 2.5 μm. The data were georeferenced, atmospherically corrected and converted to apparent surface reflectance, empirically adjusted using ground-based reflectance measurements, and combined into a mosaic with 23-m pixel spacing. Variations in water vapor and dust content of the atmosphere, in solar angle, and in surface elevation complicated correction; therefore, some classification differences may be present between adjacent flight lines. The reflectance spectrum of each pixel of HyMap™ imaging spectrometer data was compared to the reference materials in a spectral library of minerals, vegetation, water, and other materials. Minerals occurring abundantly at the surface and those having unique spectral features were easily detected and discriminated, while minerals having slightly different compositions but similar spectral features were less easily discriminated; thus, some map classes consist of several minerals having similar spectra, such as “Goethite and jarosite.” A designation of “Not classified” was assigned to the pixel when there was no match with reference spectra.

  15. Hyperspectral surface materials map of quadrangles 3668 and 3768, Baghlan (221), Taluqan (222), Imam Sahib (215), and Rustaq (216) quadrangles, Afghanistan, showing carbonates, phyllosilicates, sulfates, altered minerals, and other materials

    Science.gov (United States)

    Kokaly, Raymond F.; King, Trude V.V.; Hoefen, Todd M.; Livo, Keith E.; Johnson, Michaela R.; Giles, Stuart A.

    2013-01-01

    This map shows the spatial distribution of selected carbonates, phyllosilicates, sulfates, altered minerals, and other materials derived from analysis of airborne HyMap™ imaging spectrometer (hyperspectral) data of Afghanistan collected in late 2007. The map is one in a series of U.S. Geological Survey/Afghanistan Geological Survey quadrangle maps covering Afghanistan. Flown at an altitude of 50,000 feet (15,240 meters (m)), the HyMap™ imaging spectrometer measured reflected sunlight in 128 channels, covering wavelengths between 0.4 and 2.5 μm. The data were georeferenced, atmospherically corrected and converted to apparent surface reflectance, empirically adjusted using ground-based reflectance measurements, and combined into a mosaic with 23-m pixel spacing. Variations in water vapor and dust content of the atmosphere, in solar angle, and in surface elevation complicated correction; therefore, some classification differences may be present between adjacent flight lines. The reflectance spectrum of each pixel of HyMap™ imaging spectrometer data was compared to the reference materials in a spectral library of minerals, vegetation, water, and other materials. Minerals occurring abundantly at the surface and those having unique spectral features were easily detected and discriminated, while minerals having slightly different compositions but similar spectral features were less easily discriminated; thus, some map classes consist of several minerals having similar spectra, such as “Epidote or chlorite.” A designation of “Not classified” was assigned to the pixel when there was no match with reference spectra.

  16. Molecular clouds and star formation toward the Galactic plane within 216.25$^{\\rm o}\\le$ l $\\le$218.75$^{\\rm o}$ and $-$0.75$^{\\rm o} \\le$ b $\\le$1.25$^{\\rm o}$

    CERN Document Server

    Gong, Y; Fang, M; Zhang, S B; Su, Y; Yang, J; Jiang, Z B; Xu, Y; Wang, M; Wang, Y; Lu, D R; Sun, J X

    2016-01-01

    As a part of the Milky Way Imaging Scroll Painting (MWISP) survey, we performed a simultaneous 12CO(1-0), 13CO(1-0), C18O(1-0) mapping toward molecular clouds in a region encompassing 3.75 square degrees. We reveal three molecular clouds, the 15 km/s cloud, the 27 km/s cloud, and the 50 km/s cloud, in the surveyed region. The 50 km/s cloud is resolved with an angular resolution of around 1' for the first time. Investigating their morphology and velocity structures, we find that the 27 km/s cloud is likely affected by feedback from the stellar association Mon OB3 and the 50 km/s cloud is characterised by three large expanding molecular shells. The region is mapped in C18O (1-0) for the first time. We discover seven C18O clumps, which are likely to form massive stars, and 15 dust clumps based on the BGPS archival data. Using infrared color-color diagrams, we find 56 Class I and 107 Class II young stellar object (YSO) candidates. According to the distribution of YSO candidates, an overdensity is found around the...

  17. High-accuracy measurement of the π-p total cross section for the search of narrow baryon resonances with masses between 2,16 GeV/c2 and 5,2 GeV/c2

    International Nuclear Information System (INIS)

    The principle of the apparatus and of the momentum measurement, and the resonance detection ranges with which the study deals are presented. The acquisition systems includes a micro-computer μA. An on-line acquisition program has been developed. The principle of narrow resonance detection consists in measuring their σsub(TOT) or excitation function without taking into account systematic errors from one data acquisition to another one; this excitation function is obtained from raw data without substracting the effect of empty target. The e-, K-, antip contamination is measured. The corrections to one-line measurements consist, on one hand, of the unefficiency, and on the other hand of the overefficiency of the muon detector. Finally, the study deals with the search of N* and Δ resonances

  18. Computational prediction of MicroRNAs targeting GABA receptors and experimental verification of miR-181, miR-216 and miR-203 targets in GABA-A receptor

    OpenAIRE

    Zhao Chunling; Huang Chaoqun; Weng Tingting; Xiao Xiao; Ma Hong; Liu Lin

    2012-01-01

    Abstract Background GABA receptors are well known as the inhibitory receptors in the central nervous system and are also found in peripheral tissues. We have previously shown that GABA receptors are involved in lung development and fluid homeostasis. However, the microRNAs that regulate GABA receptors have not yet been identified. Results In this study, we used the online software, TargetScan and miRanda, to query the microRNAs that directly target GABA receptors and then selected some of the...

  19. « Frontiers and Wars: the Opium Economy in Afghanistan ». Journal of Agrarian Change, vol. 5, n° 42, 2005, pp. 191-216.

    OpenAIRE

    VAN ENGELAND, Anicée

    2007-01-01

    Cet article s’attache à décrire l’évolution de l’économie de l’opium en Afghanistan et examine les facteurs de résurgence depuis la chute des Talibans. L’A. analyse les causes historiques de la culture du pavot en relation avec les mouvements de frontières et les tentatives de cristallisation d’un État afghan ainsi que les échecs. Ces espaces de frontières que l’A. décrit comme non-étatiques dans le cas afghan ont facilité les trafics. L’A. analyse ensuite les dynamiques contemporaines de la ...

  20. Kõnetehnoloogiat edendades : [rets. : Meister, Einar. Promoting Estonian speech technology : from resources to prototypes. Dissertationes linguisticae Universitatis Tartuensis 4. Tartu : Tartu Ülikooli Kirjastus, 2003. 216 lk.] / Meelis Mihkla

    Index Scriptorium Estoniae

    Mihkla, Meelis

    2004-01-01

    Retsenseeritava raamatu põhjal kaitses Tallinna Tehnikaülikooli Küberneetika Instituudi foneetika ja kõnetehnoloogia labori juhataja Einar Meister 26. juunil 2003 Tartu Ülikoolis doktoriväitekirja

  1. Jérôme Dubois J., 2009, Les politiques publiques territoriales. La gouvernance multi-niveaux face aux défis de l’aménagement. Presses Universitaires de Rennes, 216 p.

    OpenAIRE

    Gaudin, Jean-Pierre

    2009-01-01

    Voilà un ouvrage portant sur un sujet compliqué, qui rend très bien compte analytiquement de cette complication et qui aboutit à des conclusions qui ne sont dès lors pas simples … Jérôme Dubois s’intéresse ici aux défis les plus actuels que posent les politiques publiques dans leur « déclinaison » territoriale : arbitrages souvent opaques, territoires pas toujours pertinents, logiques de « chasseurs de primes » chez les élus locaux face aux guichets nationaux et européens, etc …Dans ces condi...

  2. Multibeam collection for KN216-03: Multibeam data collected aboard Knorr from 2014-03-13 to 2014-04-01, departing from Tromso, Norway and returning to Woods Hole, MA

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  3. Comparison of trajectory models in calculations of N2-broadened half-widths and N2-induced line shifts for the rotational band of H216O and comparison with measurements

    International Nuclear Information System (INIS)

    In this work, Complex Robert-Bonamy calculations of half-widths and line shifts were done for N2-broadening of water for 1639 transitions in the rotational band using two models for the trajectories. The first is a model correct to second order in time, the Robert-Bonamy parabolic approximation. The second is the solution of Hamilton's equations. Both models use the isotropic part of the atom-atom potential to determine the trajectories. The present calculations used an intermolecular potential expanded to 20th order to assure the convergence of the half-widths and line shifts. The aim of the study is to assess if the difference in the half-widths and line shifts determined from the two trajectory models is greater than the accuracy requirements of the spectroscopic and remote sensing communities. The results of the calculations are compared with measurements of the half-widths and line shifts. It is shown that the effects of the trajectory model greatly exceed the needs of current remote sensing measurements and that line shape parameters calculated using trajectories determined by solving Hamilton's equations agree better with measurement.

  4. Radiopharmaceutical Chemistry of Targeted Radiopharmaceutics. Synthesis of 211At-Labeled Radiopharmaceuticals at High Activities for Clinical Use

    International Nuclear Information System (INIS)

    Targeted α-particle radiotherapy is an appealing approach to cancer treatment because of the potential for delivering curative doses of radiation to tumor with minimal damage to normal tissue due to a range equivalent to only a few cell diameters. Compared with β-emitters they have significant advantages from a radiobiological perspective. The LET of 211At α-particles is more than 400 times higher than the β-particles emitted by 90Y, in addition the distance between ionizing events is almost the same as that between the two strands of DNA, yielding a high probability of creating non-repairable DNA damage. It gives the ability to kill cancer cells not compromised by hypoxia, dose rate effects or cell cycle position, enhancing their attractiveness for targeted radiotherapy. However, translation of the concept to the clinic has been slow, many obstacles had to be surmounted before clinical studies could be initiated, the first clinical evaluation of a 211At- labeled mAb was made in 2001. This study circumvents many of the challenges to entering clinical studies with 211At. But several problems were encountered in maintaining efficient labeling with escalating radiation dose of alpha-particle likely related to radiolysis. The impact of the radiolysis produced by the α-particle over the labeling chemistry is much higher in comparison with typical β-emitters due to a deposition of energy in the solvent in a highly localized manner two orders of magnitude per unit volume higher than 90Y or 131I. Due to these difficulties a comprehensive basic science study about the radiolytic effects of astatine alpha-particles over the synthesis of 211At-labeled radiopharmaceuticals was carried out. Its main goal was overcoming the problem of the synthesis of 211At-labeled radiopharmaceuticals at the high activities necessaries for therapy and also to extend the shelf life of astatine elutions. Briefly this study held several steps, the first one was to study the role of solvent

  5. 40 CFR 52.1977 - Content of approved State submitted implementation plan.

    Science.gov (United States)

    2010-07-01

    .../01) 216-0066Standard ACDPs (7/1/01) 216-0070Permitting Multiple Sources at a Single Adjacent or... (Bubble) (7/1/01) Division 228—Requirements for Fuel Burning Equipment and Fuel Sulfur Content...

  6. 78 FR 13905 - Government-Owned Inventions, Available for Licensing

    Science.gov (United States)

    2013-03-01

    ... Center at Lewis Field, Code 21-14, Cleveland, OH 44135; telephone (216) 433-5754; fax (216) 433-6790... Etching of Silicon Carbide; NASA Case No.: LEW-18674-1: Polymer Electrolyte-Based Sensors; NASA Case...

  7. Dicty_cDB: SSH804 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available loning vector pDXA-3strep. 216 4e-54 2 X85119 |X85119.1 Artificial sequences clon...ing vector DNA pDXA-3H. 216 4e-54 2 X85122 |X85122.1 Artificial sequences cloning vector DNA pDXA-HY. 216 4e...-54 2 AJ510165 |AJ510165.1 Cloning vector pDXA-3FLAG. 216 4e-54 2 X85118 |X85118.1 Artificial sequences clon...ing vector DNA pDXA-3C. 216 4e-54 2 X85123 |X85123.1 Artificial sequences cloning... vector DNA pDXA-HC. 216 4e-54 2 AF269236 |AF269236.1 Cloning vector pDXA-FLAG, complete sequence. 216 4e-54 2 X85120 |X85120.1 Artif

  8. Dicty_cDB: SSH838 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 630 e-177 1 AJ510164 |AJ510164.1 Cloning vector pDXA-3strep. 216 8e-55 2 X85119 |X85119.1 Artificial sequenc...es cloning vector DNA pDXA-3H. 216 8e-55 2 X85122 |X85122.1 Artificial sequences ...cloning vector DNA pDXA-HY. 216 8e-55 2 AJ510165 |AJ510165.1 Cloning vector pDXA-3FLAG. 216 8e-55 2 X85118 |X85118.1 Artificial... sequences cloning vector DNA pDXA-3C. 216 8e-55 2 X85123 |X85123.1 Artificial sequences ...FLAG, complete sequence. 216 8e-55 2 X85120 |X85120.1 Artificial sequences cloning vector DNA pDXD-3H. 216 9

  9. Dicty_cDB: SSE603 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ector pDXA-3strep. 216 9e-54 2 X85119 |X85119.1 Artificial sequences cloning vector DNA pDXA-3H. 216 9e-54 2 X85122 |X85122.1 Artific...vector pDXA-3FLAG. 216 9e-54 2 X85118 |X85118.1 Artificial sequences cloning vect...or DNA pDXA-3C. 216 9e-54 2 X85123 |X85123.1 Artificial sequences cloning vector DNA pDXA-HC. 216 9e-54 2 AF...269236 |AF269236.1 Cloning vector pDXA-FLAG, complete sequence. 216 9e-54 2 X85120 |X85120.1 Artificial sequ...ial sequences cloning vector DNA pDXA-HY. 216 9e-54 2 AJ510165 |AJ510165.1 Cloning

  10. Dicty_cDB: SSE172 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available trep. 216 3e-54 2 X85119 |X85119.1 Artificial sequences cloning vector DNA pDXA-3...H. 216 3e-54 2 X85122 |X85122.1 Artificial sequences cloning vector DNA pDXA-HY. 216 3e-54 2 AJ510165 |AJ510...165.1 Cloning vector pDXA-3FLAG. 216 3e-54 2 X85118 |X85118.1 Artificial sequences cloning vector DNA pDXA-3...C. 216 3e-54 2 X85123 |X85123.1 Artificial sequences cloning vector DNA pDXA-HC. ...216 3e-54 2 AF269236 |AF269236.1 Cloning vector pDXA-FLAG, complete sequence. 216 3e-54 2 X85120 |X85120.1 Artificial

  11. Dicty_cDB: SSE437 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 64 |AJ510164.1 Cloning vector pDXA-3strep. 216 6e-54 2 X85119 |X85119.1 Artificial sequences cloning vector ...DNA pDXA-3H. 216 6e-54 2 X85122 |X85122.1 Artificial sequences cloning vector DNA pDXA-HY. 216 6e-54 2 AJ510...165 |AJ510165.1 Cloning vector pDXA-3FLAG. 216 6e-54 2 X85118 |X85118.1 Artificial... sequences cloning vector DNA pDXA-3C. 216 6e-54 2 X85123 |X85123.1 Artificial sequences cloning vector DNA... pDXA-HC. 216 6e-54 2 AF269236 |AF269236.1 Cloning vector pDXA-FLAG, complete sequence. 216 6e-54 2 X85120 |X85120.1 Artificial

  12. Inclusive measurement of (p,πsup(-)xn) double charge exchange reactions on bismuth from threshold to 800 MeV

    International Nuclear Information System (INIS)

    The energy dependence of the total angle-integrated cross section for the production of astatine isotopes from (p,πsup(-)xn) double charge exchange reactions on bismuth (sup(209)Bi) was measured from 120 to 800 MeV using activation and radiochemical techniques. Chemical yields were estimated by direct radioassaying of sup(211)At activity in thin (approximately 1 mg/cmsup(2)), irradiated bismuth targets. Calculations of the contributions of secondary (2-step) reactions to these measured astatine yields were performed, based partially upon the observed sup(211)At activity although even at the highest energies, the contribution to products lighter than sup(207)At was negligible. These data for products with as many as 7 neutrons removed from the doubly coherent product (sup(210)At) display nearby gaussian shapes for the mass distributions of the astatine residues with the maximum occurring for about sup(204)At. The most probable momentum transfer deduced from these distributions for the initial πsup(-) production step was 335 MeV/c. The observed excitation functions display a behaviour similar to that observed for the yield of sup(210)Po from a (p,πsup(O)) reaction on sup(209)Bi, but radically different from that observed for inclusive πsup(-) reactions on a heavy nucleus. These data are discussed in terms of recent theoretical approaches to negative pion production from bismuth. In addition, a simple, schematic model is developed to treat the rapidly decreasing percentage of the total inclusive πsup(-) emission which is observed for this double charge exchange reaction. This model reflects the capacity of a nucleus to a source of internal energetic protons

  13. Human radiation studies: Remembering the early years: Oral history of Dr. Patricia Wallace Durbin, Ph.D., conducted November 11, 1994

    International Nuclear Information System (INIS)

    This report is a transcript of an interview of Dr. Patricia Wallace Durbin by representatives of the US DOE Office of Human Radiation Research. Dr. Durbin was selected for this interview because of her knowledge of the human plutonium injections and her recollections of key figures, especially Joseph Hamilton. After a brief biographical sketch Dr. Durbin discusses her loss of research funding from DOE, her recollections concerning research into strontium metabolism as part of Project Sunshine, her recollections relating to the rationale for studies of human metabolism of radionuclides, her remembrances of Dr. Hamilton's Astatine and Plutonium research, and her experiences in gathering archival records concerning these researches

  14. EFFECT OF MECHANICAL PROPERTIES OF MARTENSITE AND LOADING RATE ON DUAL PHASE STEELS

    OpenAIRE

    BAYRAM, Ali

    1998-01-01

    In this study, steel sheet materials were used in order to obtain dual-phase steel. Specimens for this purpose have been annealed in ferrite + astatine regions at the temperatures of 740, 760, 800 and 820 °C. The specimens were annealed at the different temperatures with corresponding times 20, 40 and 60 minutes and quenched into water. As a result of this dual-phase steels at different ferrite + martensite ratio were produced. Sheet specimens were tested at the range of loading rates of 1...

  15. Alpha-decay studies of the new isotopes sup 1 sup 9 sup 1 At and sup 1 sup 9 sup 3 At

    CERN Document Server

    Kettunen, H; Grahn, T; Greenlees, P T; Jones, P; Julin, R; Juutinen, S; Keenan, A; Kuusiniemi, P; Leino, M; Leppaenen, A P; Nieminen, P; Pakarinen, J; Rahkila, P; Uusitalo, J

    2003-01-01

    Detailed alpha-decay studies have been performed for the neutron-deficient isotopes sup 1 sup 9 sup 1 At and sup 1 sup 9 sup 3 At. The nuclei were produced in fusion-evaporation reactions of sup 5 sup 4 Fe and sup 5 sup 6 Fe ions with a sup 1 sup 4 sup 1 Pr target. The fusion products were separated in-flight using a gas-filled recoil separator and implanted into a position-sensitive silicon detector. The isotopes were identified using position, time and energy correlations between the implants and subsequent alpha-decays. Three alpha-decaying states were identified for sup 1 sup 9 sup 3 At and two for sup 1 sup 9 sup 1 At. The spin and parity of the initial states in the astatine isotopes were deduced based on unhindered alpha-decays to states in the bismuth daughter nuclei. In both astatine isotopes the 1/2 sup + intruder state was determined to be the ground state and a 7/2 sup - state to be the first-excited state. In sup 1 sup 9 sup 3 At the alpha-decay of the 13/2 sup + state was observed in coincidence...

  16. Rationalization of the solvation effects on the AtO+ ground-state change.

    Science.gov (United States)

    Ayed, Tahra; Réal, Florent; Montavon, Gilles; Galland, Nicolas

    2013-09-12

    (211)At radionuclide is of considerable interest as a radiotherapeutic agent for targeted alpha therapy in nuclear medicine, but major obstacles remain because the basic chemistry of astatine (At) is not well understood. The AtO(+) cationic form might be currently used for (211)At-labeling protocols in aqueous solution and has proved to readily react with inorganic/organic ligands. But AtO(+) reactivity must be hindered at first glance by spin restriction quantum rules: the ground state of the free cation has a dominant triplet character. Investigating AtO(+) clustered with an increasing number of water molecules and using various flavors of relativistic quantum methods, we found that AtO(+) adopts in solution a Kramers restricted closed-shell configuration resembling a scalar-relativistic singlet. The ground-state change was traced back to strong interactions, namely, attractive electrostatic interactions and charge transfer, with water molecules of the first solvation shell that lift up the degeneracy of the frontier π* molecular orbitals (MOs). This peculiarity brings an alternative explanation to the highly variable reproducibility reported for some astatine reactions: depending on the production protocols (with distillation in gas-phase or "wet chemistry" extraction), (211)At may or may not readily react. PMID:23944251

  17. Dicty_cDB: SSH692 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available pDXA-3strep. 216 7e-55 2 X85119 |X85119.1 Artificial sequences cloning vector DNA pDXA-3H. 216 7e-55 2 X85122 |X85122.1 Artificial... |AJ510165.1 Cloning vector pDXA-3FLAG. 216 7e-55 2 X85118 |X85118.1 Artificial sequences cloning vector DNA... pDXA-3C. 216 7e-55 2 X85123 |X85123.1 Artificial sequences cloning vector DNA pDXA-HC. 216 7e-55 2 AF269236... |AF269236.1 Cloning vector pDXA-FLAG, complete sequence. 216 7e-55 2 X85120 |X85120.1 Artificial

  18. Dicty_cDB: SSL359 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ficial sequences cloning vector DNA pDXA-3H. 216 2e-54 2 X85122 |X85122.1 Artificial...ficial sequences cloning vector DNA pDXA-3C. 216 2e-54 2 X85123 |X85123.1 Artific...vector pDXA-FLAG, complete sequence. 216 2e-54 2 X85120 |X85120.1 Artificial sequences cloning vector DNA pD...scoideum mRNA for cysteine proteinase 1. 436 0.0 3 AJ510164 |AJ510164.1 Cloning vector pDXA-3strep. 216 2e-54 2 X85119 |X85119.1 Arti... sequences cloning vector DNA pDXA-HY. 216 2e-54 2 AJ510165 |AJ510165.1 Cloning vector pDXA-3FLAG. 216 2e-54 2 X85118 |X85118.1 Arti

  19. Dicty_cDB: SSM804 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ficial sequences cloning vector DNA pDXA-3H. 216 3e-54 2 X85122 |X85122.1 Artific...vector pDXA-3FLAG. 216 3e-54 2 X85118 |X85118.1 Artificial sequences cloning vector DNA pDXA-3C. 216 3e-54 2 X85123 |X85123.1 Artific...269236 |AF269236.1 Cloning vector pDXA-FLAG, complete sequence. 216 3e-54 2 X85120 |X85120.1 Artificial sequ...coideum mRNA for cysteine proteinase 1. 1233 0.0 1 AJ510164 |AJ510164.1 Cloning vector pDXA-3strep. 216 3e-54 2 X85119 |X85119.1 Arti...ial sequences cloning vector DNA pDXA-HY. 216 3e-54 2 AJ510165 |AJ510165.1 Cloning

  20. Dicty_cDB: SSL190 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 4.1 Cloning vector pDXA-3strep. 216 3e-67 3 X85119 |X85119.1 Artificial sequences cloning vector DNA pDXA-3H.... 216 3e-67 3 X85122 |X85122.1 Artificial sequences cloning vector DNA pDXA-HY. 2...16 3e-67 3 AJ510165 |AJ510165.1 Cloning vector pDXA-3FLAG. 216 3e-67 3 X85118 |X85118.1 Artificial sequences... cloning vector DNA pDXA-3C. 216 3e-67 3 X85123 |X85123.1 Artificial sequences cloning vector DNA pDXA-HC. 2...3e-67 3 X85120 |X85120.1 Artificial sequences cloning vector DNA pDXD-3H. 216 3e-67 3 AJ510166 |AJ510166.1 C

  1. Dicty_cDB: SSH510 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ase 1. 686 0.0 1 AJ510164 |AJ510164.1 Cloning vector pDXA-3strep. 216 1e-54 2 X85119 |X85119.1 Artificial... sequences cloning vector DNA pDXA-3H. 216 1e-54 2 X85122 |X85122.1 Artificial seque...nces cloning vector DNA pDXA-HY. 216 1e-54 2 AJ510165 |AJ510165.1 Cloning vector pDXA-3FLAG. 216 1e-54 2 X85118 |X85118.1 Artificial... sequences cloning vector DNA pDXA-3C. 216 1e-54 2 X85123 |X85123.1 Artificial...pDXA-FLAG, complete sequence. 216 1e-54 2 X85120 |X85120.1 Artificial sequences cloning vector DNA pDXD-3H.

  2. Dicty_cDB: SSK793 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available teinase 1. 1084 0.0 1 AJ510164 |AJ510164.1 Cloning vector pDXA-3strep. 216 3e-54 2 X85119 |X85119.1 Artificial... sequences cloning vector DNA pDXA-3H. 216 3e-54 2 X85122 |X85122.1 Artificial sequences cloning vector DN...cial sequences cloning vector DNA pDXA-3C. 216 3e-54 2 X85123 |X85123.1 Artificial ...quence. 216 3e-54 2 X85120 |X85120.1 Artificial sequences cloning vector DNA pDXD...A pDXA-HY. 216 3e-54 2 AJ510165 |AJ510165.1 Cloning vector pDXA-3FLAG. 216 3e-54 2 X85118 |X85118.1 Artifi

  3. "Pelas lentes do cinema. Bioética e ética em pesquisa". Dirce Guilhem, Debora Diniz, Fabio Zicker (Eds. ) . Letras Livres, Universidade de Brasí l i a , Brasília 2007, 216 páginas.

    OpenAIRE

    Lecuona Ramírez, Itziar de

    2008-01-01

    Comentario de un libro que está directamente relacionado con el binomio Bioética y Cine. Bajo el título "Pelas lentes do Cinema. Bioética e Ética em Pesquisa" subyace una interesante e innovadora propuesta pedagógica, sobre todo, desde el punto de vista metodológico, para la enseñanza de la Bioética a través de las películas y los documentales.

  4. 寰枕膜松解术配合颈椎调衡术治疗椎动脉型颈椎病216例%Treatment of cervical spondylopathy of carotid type with relaxation of atloido- occipital membrane combing cervical vertebrae rebalancing operation

    Institute of Scientific and Technical Information of China (English)

    姜永庆; 杨显声; 陈立民

    2002-01-01

    @@ Background:Cervical spondylopathy is generally called for a series of symptoms because of ischemia of the head caused by compression of stimulation of the carotid artery by proliferated osteophyte around cervical vertebrae or spasmic muscle or tissue cord.

  5. Book Review: Feng Tian-yu and Xie Gui-an (2003) Destructing Despotism: Research on Neo-people- oriented Thought in Late Ming & Early Qing Dynasty , Hubei, P.R.China: Hubei Publishing House, ISBN 7-216-03727-8 / D

    OpenAIRE

    Qianfang, Xia

    2006-01-01

    Is Chinese neo-people-oriented thought a completely endogenous phenomenon or is it an outcome of eastern-western cultural exchange? This is a vexed problem that has been puzzling Chinese academia for a long period. Some scholars argue that all through its history China has never had any democratic tradition, since the required soil for the production of democracy in terms of political culture is absent. On the contrary, other scholars contend that old-line Chinese peopleoriented thought is ac...

  6. Quality-controlled sea surface temperature, salinity and other measurements from thermosalinographs (TSG) from the CORNIDE DE SAAVEDRA, METEOR and 216 other platforms in the Atlantic, Pacific, Indian Oceans and other locations from 1989-7-20 to 2016-7-31 (NCEI Accession 0156189)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — To facilitate understanding of, and access to, the information available for in situ sea surface measurements, NOAA NCEI has constructed a Global Thermosalinographs...

  7. Fruit intake associated with urinary estrogen metabolites in healthy premenopausal women

    OpenAIRE

    Reding, Kerryn W.; Atkinson, Charlotte; Westerlind, Kim C.; Stanczyk, Frank; Bowles, Erin J. Aiello; Yong, Mellissa; Newton, Katherine M.; Lampe, Johanna W.

    2012-01-01

    Urinary concentrations of 2:16-hydroxyestrone (2:16-OHE1) approximate concentrations of 2-OHE1 and 16α -OHE1 in breast tissue. As estrogens are purported to be involved in breast cancer development, the 2:16-OHE1 ratio can provide an indication of estrogen metabolite exposure in the breast. With prior studies observing associations between urinary estrogen metabolites and dietary intake of fruits, vegetables, and fiber ascertained from food questionnaires, we examined associations between die...

  8. Dicty_cDB: Contig-U08414-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available gtcgttgnattatctaca 70 Query: 71 acttttctttcnccnactgttgaattaaccgtncaactcaataatgatgattcttcaact 130 |||||||||||...||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct: 71 acttttctttcnccnactgtt...|||||||||||||||||| Sbjct: 275 aaattaggaagtgcacctttgataaatcaattctaaanncngtcgttgnattatctacaa 216 Query: 72 cttttctttcnccna...|||||||||||||| Sbjct: 215 cttttctttcnccnactgttgaattaaccgtncaactcaataatgatgattcttcaactc 156 Query: 132 atacca

  9. Sediment traps as a new tool for estimation of longevity of planktonic foraminifera

    Digital Repository Service at National Institute of Oceanography (India)

    Nigam, R.

    stream_size 9 stream_content_type text/plain stream_name Antarct_Geosci_Ocean-Atmos_Interact_Paleocli_2005_216.pdf.txt stream_source_info Antarct_Geosci_Ocean-Atmos_Interact_Paleocli_2005_216.pdf.txt Content-Encoding ISO-8859...

  10. 76 FR 24024 - Request for Information Relating to Studies Regarding the Resolution of Financial Companies Under...

    Science.gov (United States)

    2011-04-29

    ... information. SUMMARY: Section 216 of the Dodd-Frank Wall Street Reform and Consumer Protection Act (the ``Dodd... regarding international coordination relating to the resolution of systemic financial companies under the Bankruptcy Code and applicable foreign law. Section 216 and Section 217 of the Dodd-Frank Act each...

  11. Drug: D01421 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available purate sodium; Paraaminohippurate (TN) C9H9N2O3. Na 216.0511 216.1691 D01421.gif Diagnostic aid [renal funct...ly for therapeutic purpose 72 Intracorporeal diagnostic agents 722 Various function testing reagents 7225 Diagnostic

  12. Speciation and behaviour of Cd, Pb and Cu in Zuari Estuary, west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    George, M.D

    stream_size 5 stream_content_type text/plain stream_name Indian_J_Mar_Sci_22_216.pdf.txt stream_source_info Indian_J_Mar_Sci_22_216.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  13. Review for the Korean Health Professionals and International Cooperation Doctors Dispatched to Peru by the Korea International Cooperation Agency (KOICA).

    Science.gov (United States)

    Kim, Bongyoung

    2015-04-01

    South Korea dispatches Korean nationals to partner developing countries as an Official Development Assistance (ODA) project through the Korea International Cooperation Agency (KOICA). In the health sector, KOICA dispatches international cooperation doctors (ICDs), nurses, physical therapists, radiologic technologists, nutritionists, medical laboratory technologists, occupational therapists, and dental hygienists. A total of 216 ICDs were dispatched over 19 times from 1995 until 2013. There were 19 areas of specialties among the ICDs. The most common specialty was internal medicine (61/216, 28.2%), the second most common specialty was general surgery (43/216, 19.9%), followed by oriental medicine (27/216, 12.5%), pediatrics (17/216, 7.9%), orthopedics (16/216, 7.4%), family medicine (16/216, 7.4%), and odontology (14/216, 6.5%). The ICDs have worked in 21 countries. KOICA dispatched the highest number of ICDs to Asia (97/216, 44.9%), followed by Africa (50/216, 23.1%), Latin America (34/216, 15.7%), the commonwealth of independent states (31/216, 14.4%), and Oceania (4/216, 1.9%). Nobody was dispatched to the Middle East. A total of 134 KOICA health professionals were dispatched to Peru from 1996 until October 1, 2014. Of these, 19.4% (26/134) were ICDs, 44.8% (60/216) were nurses, 20.1% (27/134) were physical therapists, 6.7% (9/134) were radiologic technologists, 2.2% (3/134) were nutritionists, and 6.7% (9/134) were medical laboratory. ICDs' specialties comprised internal medicine (13/26, 50%), family medicine (8/26, 30.8%), pediatrics (2/26, 7.7%), otorhinolaryngology (1/26, 3.8%), orthopedics (1/26, 3.8%), and oriental medicine (1/26, 3.8%). Most of the dispatched health professionals worked at institutions that were supported by KOICA. For this reason, the proportion of health professionals who worked at public health centers (PHCs) was the highest (58.2%, 78/134) when classified by workplace type. Other KOICA health professionals worked at hospitals

  14. Review for the Korean Health Professionals and International Cooperation Doctors Dispatched to Peru by the Korea International Cooperation Agency (KOICA).

    Science.gov (United States)

    Kim, Bongyoung

    2015-04-01

    South Korea dispatches Korean nationals to partner developing countries as an Official Development Assistance (ODA) project through the Korea International Cooperation Agency (KOICA). In the health sector, KOICA dispatches international cooperation doctors (ICDs), nurses, physical therapists, radiologic technologists, nutritionists, medical laboratory technologists, occupational therapists, and dental hygienists. A total of 216 ICDs were dispatched over 19 times from 1995 until 2013. There were 19 areas of specialties among the ICDs. The most common specialty was internal medicine (61/216, 28.2%), the second most common specialty was general surgery (43/216, 19.9%), followed by oriental medicine (27/216, 12.5%), pediatrics (17/216, 7.9%), orthopedics (16/216, 7.4%), family medicine (16/216, 7.4%), and odontology (14/216, 6.5%). The ICDs have worked in 21 countries. KOICA dispatched the highest number of ICDs to Asia (97/216, 44.9%), followed by Africa (50/216, 23.1%), Latin America (34/216, 15.7%), the commonwealth of independent states (31/216, 14.4%), and Oceania (4/216, 1.9%). Nobody was dispatched to the Middle East. A total of 134 KOICA health professionals were dispatched to Peru from 1996 until October 1, 2014. Of these, 19.4% (26/134) were ICDs, 44.8% (60/216) were nurses, 20.1% (27/134) were physical therapists, 6.7% (9/134) were radiologic technologists, 2.2% (3/134) were nutritionists, and 6.7% (9/134) were medical laboratory. ICDs' specialties comprised internal medicine (13/26, 50%), family medicine (8/26, 30.8%), pediatrics (2/26, 7.7%), otorhinolaryngology (1/26, 3.8%), orthopedics (1/26, 3.8%), and oriental medicine (1/26, 3.8%). Most of the dispatched health professionals worked at institutions that were supported by KOICA. For this reason, the proportion of health professionals who worked at public health centers (PHCs) was the highest (58.2%, 78/134) when classified by workplace type. Other KOICA health professionals worked at hospitals

  15. Dicty_cDB: SSD429 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 622 e-175 1 AJ510162 |AJ510162.1 Cloning vector pDXA-YFP-NotI. 216 1e-52 1 X85120 |X85120.1 Artificial seque...pDXA-GFP2, complete sequence. 216 1e-52 1 X85122 |X85122.1 Artificial sequences cloning vector DNA pDXA-HY. ...XA-CFP. 216 1e-52 1 X85123 |X85123.1 Artificial sequences cloning vector DNA pDXA...-HC. 216 1e-52 1 X85119 |X85119.1 Artificial sequences cloning vector DNA pDXA-3H. 216 1e-52 1 AJ510166 |AJ5

  16. Dicty_cDB: SSJ694 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available steine proteinase 1. 1217 0.0 1 AJ510164 |AJ510164.1 Cloning vector pDXA-3strep. 216 8e-54 2 X85119 |X85119.1 Artificial... sequences cloning vector DNA pDXA-3H. 216 8e-54 2 X85122 |X85122.1 Artificial...216 8e-54 2 X85118 |X85118.1 Artificial sequences cloning vector DNA pDXA-3C. 216 8e-54 2 X85123 |X85123.1 Artificial...Cloning vector pDXA-FLAG, complete sequence. 216 8e-54 2 X85120 |X85120.1 Artificial sequences cloning vecto

  17. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    CERN Document Server

    Marsh, B A; Imai, N; Seliverstov, M D; Rothe, S; Sels, S; Capponi, L; Rossel, R E; Franchoo, S; Wendt, K; Focker, G J; Kalaninova, Z; Sjoedin, A M; Popescu, L; Nicol, T; Huyse, M; Radulov, D; Atanasov, D; Kesteloot, N; Borgmann, Ch; Cocolios, T E; Lecesne, N; Ghys, L; Pauwels, D; Rapisarda, E; Kreim, S; Liberati, V; Wolf, R N; Andel, B; Schweikhard, L; Lane, J; Derkx, X; Kudryavtsev, Yu; Zemlyanoy, S G; Fedosseev, V N; Lynch, K M; Rosenbusch, M; Van Duppen, P; Lunney, D; Manea, V; Barzakh, A E; Andreyev, A N; Truesdale, V; Flanagan, K T; Molkanov, P L; Koester, U; Van Beveren, C; Wienholtz, F; Goodacre, T Day; Antalic, S; Bastin, B; De Witte, H; Fink, D A; Fedorov, D V

    2013-01-01

    At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar fr...

  18. Development of 211At Chemistry for Labelling Biomolecules

    International Nuclear Information System (INIS)

    Our studies have demonstrated that high recovery of 211At can be obtained using a “wet chemistry” approach to isolation from the bismuth target. We have also demonstrated that direct labelling of antibody-B10 conjugates with 211At can be performed in high yields, and that the astatinated antibodies are stable to in vivo deastatination. While these results will allow us to enter clinical studies with 211At-labelled antibodies, the chemistry associated with 211At is not fully understood. Therefore, it is important that many more basic studies to be conducted with 211At, so the optimal labelling reagent for each type of disease-targeting agent becomes apparent

  19. Alpha particle induced DNA damage and repair in normal cultured thyrocytes of different proliferation status

    DEFF Research Database (Denmark)

    Lyckesvärd, Madeleine Nordén; Delle, Ulla; Kahu, Helena;

    2014-01-01

    Childhood exposure to ionizing radiation increases the risk of developing thyroid cancer later in life and this is suggested to be due to higher proliferation of the young thyroid. The interest of using high-LET alpha particles from Astatine-211 ((211)At), concentrated in the thyroid by the same...... levels of γH2AX decreased during the first 24h in both cycling and stationary cultures and complete repair was seen in all cultures but cycling cells exposed to (211)At. Compared to stationary cells alpha particles were more harmful for cycling cultures, an effect also seen at the pChk2 levels...... cultures at a modest level of damage, clearly demonstrating that cell cycle status influences the relative effectiveness of alpha particles....

  20. EFFECT OF MECHANICAL PROPERTIES OF MARTENSITE AND LOADING RATE ON DUAL PHASE STEELS

    Directory of Open Access Journals (Sweden)

    Ali BAYRAM

    1998-03-01

    Full Text Available In this study, steel sheet materials were used in order to obtain dual-phase steel. Specimens for this purpose have been annealed in ferrite + astatine regions at the temperatures of 740, 760, 800 and 820 °C. The specimens were annealed at the different temperatures with corresponding times 20, 40 and 60 minutes and quenched into water. As a result of this dual-phase steels at different ferrite + martensite ratio were produced. Sheet specimens were tested at the range of loading rates of 10, 50 and 259 mm/min. Strength properties of dual-phase steels were investigated depending on annealing temperature, ratio of martensite and loading rate.

  1. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    Energy Technology Data Exchange (ETDEWEB)

    Marsh, B.A., E-mail: bruce.marsh@cern.ch [CERN, CH-1211 Geneva (Switzerland); Andel, B. [Comenius University, Bratislava (Slovakia); Andreyev, A.N. [University of York, Department of Physics, York YO10 5DD (United Kingdom); Antalic, S. [Comenius University, Bratislava (Slovakia); Atanasov, D. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Barzakh, A.E. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Bastin, B. [Grand Accérateur National d’Ions Lourds (GANIL), Bd Henri Becquerel, F-14076 Caen (France); Borgmann, Ch. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Capponi, L. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Cocolios, T.E.; Day Goodacre, T. [CERN, CH-1211 Geneva (Switzerland); University of Manchester, Manchester (United Kingdom); Dehairs, M. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Derkx, X. [University of the West of Scotland, School of Engineering, Paisley PA1 2BE (United Kingdom); De Witte, H. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Fedorov, D.V. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Fedosseev, V.N.; Focker, G.J. [CERN, CH-1211 Geneva (Switzerland); Fink, D.A. [Ruprecht-Karls Universität, Seminarstr. 2, 69117 Heidelberg (Germany); CERN, CH-1211 Geneva (Switzerland); Flanagan, K.T. [University of Manchester, Manchester (United Kingdom); Franchoo, S. [CSNSM-IN2P3-CNRS, Université Paris-Sud, 91406 Orsay (France); and others

    2013-12-15

    Highlights: • Upgrade of the lasers, detectors and data acquisition for in-source resonance ionization spectroscopy at ISOLDE. • First use of the ISOLTRAP MR-ToF MS in combination with laser spectroscopy at ISOLDE. • Resonance ionization of astatine for the study of its nuclear structure. -- Abstract: At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar free ionization using the Laser Ion Source Trap, LIST (Po); isobar selective particle identification using the multi-reflection time-of-flight mass separator (MR-ToF MS) of ISOLTRAP (Au, At). These are summarized as part of an overview of the current status of the in-source resonance ionization spectroscopy setup at ISOLDE.

  2. Carga parasitária de Rondonia rondoni, Travassos, 1920 (Nematoda, Atrictidae e fator de condição do armado, Pterodoras granulosus, Valenciennes, 1833 (Pisces, Doradidae - DOI: 10.4025/actascibiolsci.v26i2.1613 Effect of parasitic load of Rondonia rondoni, Travassos, 1920 (Nematoda, Atrictidae over the condition factor of thorny catfish Pterodoras Granulosus (Valenciennes, 1833 (Pisces, Doradidae - DOI: 10.4025/actascibiolsci.v26i2.16

    Directory of Open Access Journals (Sweden)

    Marion Haruko Machado

    2004-04-01

    Full Text Available Objetiva-se avaliar o efeito da carga parasitária de Rondonia rondoni sobre o fator de condição de armados, Pterodoras granulosus. Foram necropsiados 51 espécimes de armados, coletados no rio Paraná (Porto Rico/Paraná. Para as análises, utilizaram-se os testes de “t”, de Student, para determinar se o comprimento dos hospedeiros machos e fêmeas eram semelhantes; “U”, de Mann-Whitney, para determinar o efeito do sexo do hospedeiro na intensidade de infecção da espécie de parasito; “G” Log-likelihood, para determinar o efeito do sexo do hospedeiro na prevalência do parasito; coeficiente de correlação (CC “r”, para determinar a correlação entre o comprimento do hospedeiro e a prevalência de infecção; CC por postos de Spearman “rs”, para determinar as possíveis correlações entre a intensidade de infecção e a diversidade parasitária com o comprimento do hospedeiro e para verificar a correlação entre a intensidade parasitária e o fator de condição (K. Os resultados permitiram concluir que, apesar das variações no comprimento entre machos e fêmeas, o sexo não influencia na intensidade e na prevalência de infecção. Porém a intensidade de parasitismo e a prevalência aumentaram com o incremento do comprimento do hospedeiro, e a intensidade parece não afetar o fator de condição de armado, o qual parece estar em equilíbrio com esse parasita nesse ambienteAiming to evaluate the effect of parasitic load of Rondonia rondoni over the condition factor of Pterodoras granulosus. Fifty one specimens of P. granulosus were collected in Paraná River, (Porto Rico/Paraná. To analyze were used: Student’s “t”, to determine if length of hosts males and females were similar; Mann-Whitney test “U”, to determine the effect of sex of host on the intensity of infestion of the parasite; “G” Log-likelihood test, to determine the effect of sex of the host on the prevalence of parasite; coefficient of correlation “r”, to determine the correlation between the length of host and the prevalence of infection; Spearman rank correlation coefficient “rs”, to determine as possible correlation’s between the intensity of infection and the parasitic diversity with the length of the host, and to examine the correlation between the parasitic intensity and the condition factor (K. Based in this results we conclude, that despite of variations in the length, between males and females, the sex does not influence in the intensity and prevalence of infection. However, the intensity of parasites and the prevalence of R. rondoni increased with the length of host being that, the intensity does not affect the condition factor of Pterodoras granulosus, which mean to be in equilibrium with the parasite in this local

  3. N-甲氧基-N-[2-(1,6-2H-1-取代-6-羰基-哒嗪-3-氧甲基)苯基]氨基甲酸甲酯的合成及生物活性研究%Synthesis and Biological Activity of Methyl N-Methoxy-N-[2-(1,6-dihydro-1-substituent-6-oxo-pyridazin-3-yloxymethyl)phenl]carbamates

    Institute of Scientific and Technical Information of China (English)

    刘卫东; 李志伟; 李仲英; 王晓光; 高必达

    2005-01-01

    为了寻找高效、低毒的农药,设计合成了一系列新的N-甲氧基-N-[2-(1,6-2H-1-取代-6-羰基-哒嗪-3-氧甲基)苯基]氨基甲酸甲酯化合物3a~3k,其结构经IR,1H NMR,LC/MS和元素分析确认.生物活性测定表明,部分化合物在50mg/L下对小麦赤霉病菌(Gibberella zeae)、稻瘟病菌(Pyricularia oryzae)和黄瓜灰霉病菌(Botrytis cinerea)有较好的抑菌活性.

  4. Analysis of natural isolates of Lactobacilli resistant to bacteriocin nisin

    Directory of Open Access Journals (Sweden)

    Strahinić Ivana D.

    2005-01-01

    Full Text Available The collection of lactic acid bacteria (LAB was made by isolation of microorganisms from fermented products traditionally manufactured in different geographical regions (high mountains, river valleys, seaside, etc. Among collected LAB, 51 isolates were identified as Lactobacillus sp. Results showed that all isolated lactobacilli were mesophilic strains, since they grew at 15°C and 30°C but not at 45°C. Testing the ability of isolated lactobacilli to grow in the presence of nisin revealed that Lactobacillus sp. isolates designed BGCGK4, BGHN40, BGBUK2-8, BGBUK2-7 and BGBUK2-16 were resistant to nisin. Determination of the minimal inhibitory concentrations (MIC for nisin revealed that the most resistant isolate was Lactobacillus sp. BGCGK4. Isolate BGBUK2-16, determined as Lactobacillus paracasei subsp. paracasei, produces bacteriocin, named Bac217 and showed a resistance to 8000 IU/ml of nisin. Plasmid curing of BGBUK2-16 resulted in derivatives BGBUK2-16/K2 and BGBUK2-16/K4. Derivative BGBUK2-16/K2 retained resistance to Bac217 and nisin, but lost the ability to synthesise Bac217. Derivative BGBUK2-16/K4 lost concomitantly the resistance to both Bac217 and nisin.

  5. The Surgical Management of Concomitant Gallbladder and Common Bile Duct Stones.

    Science.gov (United States)

    Darrien, J H; Connor, K; Janeczko, A; Casey, J J; Paterson-Brown, S

    2015-01-01

    Background. The management of choledocholithiasis has evolved from open common bile duct exploration (OCBDE) to therapeutic endoscopic retrograde cholangiopancreatography (ERCP) to laparoscopic common bile duct exploration (LCBDE). Each entails a degree of difficulty. Aim. To review 5-year results of bile duct exploration in an UGI unit. Methods. Common bile duct explorations (CBDEs) performed between January 2008 and January 2013 were identified from a prospectively collected clinical audit system and results reviewed retrospectively. Results. 216 CBDEs were performed, 119 (55%) as an emergency and 52 (24%) following failed ERCP. Open CBDE (OCBDE) was performed primarily in 34/216 (16%) patients and attempted laparoscopically in 182 (84%). Fifty nine (32%) Laparoscopic CBDEs (LCBDEs) were converted to OCBDE. Of the remaining 123 LCBDEs, 51 (41%) primary choledochotomies and 72 (59%) primary transcystic CBDEs (TC-CBDEs) were performed. Forty nine (68%) TC-CBDEs were considered successful and 23 (32%) failed. Fifteen failed TC-CBDEs were converted to a successful laparoscopic choledochotomy. Ductal clearance was achieved in 187/216 (87%) patients and retained stones were identified in 20/123 (16%) LCBDEs. Complications occurred in 52/216 (24%) patients. There were 8/216 (4%) bile leaks requiring further intervention. Postoperative ERCP was carried out in 32/216 (15%) patients and 9/216 (4%) required relaparoscopy/laparotomy. No patient died. Conclusions. Successful management of choledocholithiasis requires a breadth of laparoscopic and endoscopic expertise. PMID:26420916

  6. The Surgical Management of Concomitant Gallbladder and Common Bile Duct Stones

    Directory of Open Access Journals (Sweden)

    J. H. Darrien

    2015-01-01

    Full Text Available Background. The management of choledocholithiasis has evolved from open common bile duct exploration (OCBDE to therapeutic endoscopic retrograde cholangiopancreatography (ERCP to laparoscopic common bile duct exploration (LCBDE. Each entails a degree of difficulty. Aim. To review 5-year results of bile duct exploration in an UGI unit. Methods. Common bile duct explorations (CBDEs performed between January 2008 and January 2013 were identified from a prospectively collected clinical audit system and results reviewed retrospectively. Results. 216 CBDEs were performed, 119 (55% as an emergency and 52 (24% following failed ERCP. Open CBDE (OCBDE was performed primarily in 34/216 (16% patients and attempted laparoscopically in 182 (84%. Fifty nine (32% Laparoscopic CBDEs (LCBDEs were converted to OCBDE. Of the remaining 123 LCBDEs, 51 (41% primary choledochotomies and 72 (59% primary transcystic CBDEs (TC-CBDEs were performed. Forty nine (68% TC-CBDEs were considered successful and 23 (32% failed. Fifteen failed TC-CBDEs were converted to a successful laparoscopic choledochotomy. Ductal clearance was achieved in 187/216 (87% patients and retained stones were identified in 20/123 (16% LCBDEs. Complications occurred in 52/216 (24% patients. There were 8/216 (4% bile leaks requiring further intervention. Postoperative ERCP was carried out in 32/216 (15% patients and 9/216 (4% required relaparoscopy/laparotomy. No patient died. Conclusions. Successful management of choledocholithiasis requires a breadth of laparoscopic and endoscopic expertise.

  7. Aliisedimentitalea scapharcae gen. nov., sp. nov., isolated from ark shell Scapharca broughtonii.

    Science.gov (United States)

    Kim, Young-Ok; Park, Sooyeon; Nam, Bo-Hye; Kim, Dong-Gyun; Won, Sung-Min; Park, Ji-Min; Yoon, Jung-Hoon

    2015-08-01

    A Gram-negative, aerobic, non-spore-forming, motile and ovoid or rod-shaped bacterial strain, designated MA2-16(T), was isolated from ark shell (Scapharca broughtonii) collected from the South Sea, South Korea. Strain MA2-16(T) was found to grow optimally at 30°C, at pH 7.0-8.0 and in the presence of 2.0% (w/v) NaCl. Neighbour-joining, maximum-likelihood and maximum-parsimony phylogenetic trees based on 16S rRNA gene sequences revealed that strain MA2-16(T) clustered with the type strain of Sedimentitalea nanhaiensis. The novel strain exhibited a 16S rRNA gene sequence similarity value of 97.1% to the type strain of S. nanhaiensis. In the neighbour-joining phylogenetic tree based on gyrB sequences, strain MA2-16(T) formed an evolutionary lineage independent of those of other taxa. Strain MA2-16(T) contained Q-10 as the predominant ubiquinone and C18:1 ω7c and 11-methyl C18:1 ω7c as the major fatty acids. The major polar lipids of strain MA2-16(T) were phosphatidylcholine, phosphatidylglycerol, phosphatidylethanolamine, an unidentified aminolipid and an unidentified lipid. The DNA G+C content of strain MA2-16(T) was 57.7 mol% and its DNA-DNA relatedness values with the type strains of S. nanhaiensis and some phylogenetically related species of the genera Leisingera and Phaeobacter were 13-24%. On the basis of the data presented, strain MA2-16(T) is considered to represent a novel genus and novel species within the family Rhodobacteraceae, for which the name Aliisedimentitalea scapharcae gen. nov., sp. nov. is proposed. The type strain is MA2-16(T) (=KCTC 42119(T) =CECT 8598(T)).

  8. Libraries in Maryland: MedlinePlus

    Science.gov (United States)

    ... Box 800 Cambridge, MD 21613 888-216-8110 ext. 2485 Cheverly Prince George's Hospital Center Medical Library ... Suite 500 Landover, MD 20785 800-444-6472 ext. 3108 http://minorityhealth.hhs.gov/omh/browse.aspx? ...

  9. Origin and spectral degradation of the photoluminescence from a-SiOx

    Science.gov (United States)

    Kistner, J.; Schubert, M. B.

    2013-11-01

    This paper reports for the first time on a spectral degradation of photoluminescence from a-SiOx that occurs due to the storage of the samples in ambient atmosphere. The spectra of samples with an initial emission peak EPL,ini > 2.16 eV shift to lower energies. The degraded spectra have a common maximum at EPL,deg ≈ 2.16 eV. In the spectra of samples with EPL,ini EPL ≈ 2.16 eV develops. The initial photoluminescence spectra result from radiative recombination between tail states. The degraded luminescence is dominated by two effects. On the one hand, band tail luminescence still occurs. On the other hand, the prevalent emission around EPL,deg ≈ 2.16 eV originates from recombination attributed to Si = O bonds.

  10. The Slaw and the Slow Cooked: Culture and Barbecue in the Mid-South

    OpenAIRE

    Jon D. Holtzman

    2012-01-01

    Review of The Slaw and the Slow Cooked: Culture and Barbecue in the Mid-South. James R. Veteto and Edward M. Maclin, eds. 2011 Vanderbilt University Press, Nashville. Pp. 216 $22.95 (paperback). ISBN 978-0826518019. 

  11. Mapping the Kathmandu Valley With Aerial Photographs by Erwin Schneider

    Directory of Open Access Journals (Sweden)

    Urmi Sengupta

    2015-11-01

    Full Text Available Reviewed: Mapping the Kathmandu Valley With Aerial Photographs by Erwin Schneider By Neils Gutschow and Hermann Kreutzmann. Kathmandu, Nepal: Himal Books, 2013. 216 pp. US $ 48.00. ISBN 978-9937-597-06-7.

  12. Assessing Interdisciplinary Education in U.S. Dental Hygiene Programs.

    Science.gov (United States)

    Holt, Lorie; Bray, Kimberly; Mayberry, Bill; Overman, Pamela

    2000-01-01

    Survey responses from 136 of 216 dental hygiene programs indicated that 31% included interdisciplinary activities in the curriculum; only 15% included both clinical and instructional interdisciplinary coursework. However, 74% felt that students would benefit from interdisciplinary experiences. (SK)

  13. 76 FR 62810 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

    Science.gov (United States)

    2011-10-11

    ... of the collection of information is 216 hours. In the Federal Register of April 15, 2011 (76 FR 21379... of news articles on a hypothetical food recall): An ``anger'' scenario, a ``fear'' scenario, or...

  14. State waste discharge permit application: Hydrotest, maintenance and construction discharges. Revision 0

    International Nuclear Information System (INIS)

    On December 23, 1991, the US DOE< Richland Operation Office (RL) and the Washington State Department of Ecology (Ecology) agreed to adhere to the provisions of the Department of Ecology Consent Order No. DE91NM-177 (216 Consent Order) (Ecology and US DOE 1991). The 216 Consent Order list regulatory milestones for liquid effluent streams at the Hanford Site and requires compliance with the permitting requirements of Washington Administrative Code. Hanford Site liquid effluent streams discharging to the soil column have been categorized on the 216 Consent Order as follows: Phase I Streams; Phase II Streams; Miscellaneous Streams. Phase I and Phase II Streams were initially addressed in two report. Miscellaneous Streams are subject to the requirements of several milestones identified in the 216 Consent Order. This document constitutes the Categorical State Waste Discharge Permit application for hydrotest,maintenance and construction discharges throughout the Hanford Site. This categorical permit application form was prepared and approved by Ecology

  15. State waste discharge permit application: Hydrotest, maintenance and construction discharges. Revision 0

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-11-01

    On December 23, 1991, the US DOE< Richland Operation Office (RL) and the Washington State Department of Ecology (Ecology) agreed to adhere to the provisions of the Department of Ecology Consent Order No. DE91NM-177 (216 Consent Order) (Ecology and US DOE 1991). The 216 Consent Order list regulatory milestones for liquid effluent streams at the Hanford Site and requires compliance with the permitting requirements of Washington Administrative Code. Hanford Site liquid effluent streams discharging to the soil column have been categorized on the 216 Consent Order as follows: Phase I Streams; Phase II Streams; Miscellaneous Streams. Phase I and Phase II Streams were initially addressed in two report. Miscellaneous Streams are subject to the requirements of several milestones identified in the 216 Consent Order. This document constitutes the Categorical State Waste Discharge Permit application for hydrotest,maintenance and construction discharges throughout the Hanford Site. This categorical permit application form was prepared and approved by Ecology.

  16. Mapping the Kathmandu Valley With Aerial Photographs by Erwin Schneider

    OpenAIRE

    Urmi Sengupta

    2015-01-01

    Reviewed: Mapping the Kathmandu Valley With Aerial Photographs by Erwin Schneider By Neils Gutschow and Hermann Kreutzmann. Kathmandu, Nepal: Himal Books, 2013. 216 pp. US $ 48.00. ISBN 978-9937-597-06-7.

  17. 48 CFR 1316.601-70 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Time-and-Materials, Labor-Hour, and Letter Contracts 1316.601-70 Contract clauses. Insert clause 1352.216-77, Ceiling Price, in all time-and-materials contracts....

  18. 15 CFR 700.21 - Application for priority rating authority.

    Science.gov (United States)

    2010-01-01

    ... Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE NATIONAL SECURITY INDUSTRIAL BASE REGULATIONS DEFENSE PRIORITIES AND ALLOCATIONS SYSTEM Industrial Priorities for Energy Programs... published in 10 CFR part 216....

  19. 10 CFR Appendix A to Part 1040 - Federal Financial Assistance of the Department of Energy to Which This Part Applies

    Science.gov (United States)

    2010-01-01

    ... Regulations 10 CFR 216; Department of Energy Organization Act, 42 U.S.C. 7101; Public Law 95-91. 29. Basic energy sciences, high energy and nuclear physics, and advanced technology and assessment projects....

  20. Weather-related Tree Swallow Mortality and Reduced Nesting Effort

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report documents the spring 2007 die-off of 216 Tree Swallows in western New York due to a period of unseasonably warm temperatures followed immediately by a...

  1. Distributed Mode Filtering Rod Fiber Amplifier With Improved Mode Stability

    DEFF Research Database (Denmark)

    Laurila, Marko; Alkeskjold, Thomas Tanggaard; Broeng, Jes;

    2012-01-01

    We report 216W of average output power from a photonic crystal rod fiber amplifier. We demonstrate 44% power improvement before onset of the mode instability by operating the rod fiber in a leaky guiding regime.......We report 216W of average output power from a photonic crystal rod fiber amplifier. We demonstrate 44% power improvement before onset of the mode instability by operating the rod fiber in a leaky guiding regime....

  2. Review: Lisa Mackenrodt, Swahili Spirit Possession and Islamic Healing in Contemporary Tanzania: The Jinn Fly on Friday (2011 Buchbesprechung: Lisa Mackenrodt, Swahili Spirit Possession and Islamic Healing in Contemporary Tanzania: The Jinn Fly on Friday (2011

    Directory of Open Access Journals (Sweden)

    Jigal Beez

    2013-01-01

    Full Text Available Review of the monograph:Lisa Mackenrodt, Swahili Spirit Possession and Islamic Healing in Contemporary Tanzania: The Jinn Fly on Friday, Hamburg: Verlag Dr. Kovač, 2011, ISBN 978-3-8300-5806-9, 216 pagesBesprechung der Monographie:Lisa Mackenrodt, Swahili Spirit Possession and Islamic Healing in Contemporary Tanzania: The Jinn Fly on Friday, Hamburg: Verlag Dr. Kovač, 2011, ISBN 978-3-8300-5806-9, 216 Seiten

  3. Ownership structure, sharing of control and legal framework. International evidence

    OpenAIRE

    López de Foronda Pérez, Óscar; López Iturriaga, Félix Javier; Santamaría Mariscal, Marcos

    2007-01-01

    Analizamos la relación entre estructura del capital, estructura de la propiedad, y gobierno corporativo para una muestra de 1.216 empresas de 15 países europeos. Nuestros resultados recojen dos conflictos de intereses diferentes y muestran el papel diferencial jugado por los mecanismos de control corporativo dependiendo del ambiente legal e institucional. We analyze the relation between capital structure, ownership structure, and corporate value for a sample of 1,216 firms from 15 Europea...

  4. 国际纺织品求购信息

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    国别:UNITED STATES美国 厂商:TITAN INTERNATIONAL IMPORT—EXPORT §CONSULTING CO。L 地址:IMES SAN SIT E—BLOK 504 SK.NO 51 YDUDULLU IMES SAN SIT 联系人E—SAADETTIN CAYO 51 Y DUDULLU IS-TANBUL TURKEY 电话:90—216—420—0920 传真:90—216—313—4419 国外进口:医院用床单

  5. Inhibition of PAI-1 Limits Tumor Angiogenesis Regardless of Angiogenic Stimuli in Malignant Pleural Mesothelioma.

    Science.gov (United States)

    Takayama, Yusuke; Hattori, Noboru; Hamada, Hironobu; Masuda, Takeshi; Omori, Keitaro; Akita, Shin; Iwamoto, Hiroshi; Fujitaka, Kazunori; Kohno, Nobuoki

    2016-06-01

    Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor that secretes various angiogenic factors. The main inhibitor of plasminogen activators, PAI-1 (SERPINE1), has been implicated in tumor progression and angiogenesis, and high PAI-1 expression has been associated with poor prognosis in MPM patients. In this study, we examined the antiangiogenic effects of PAI-1 inhibition in MPM. We administered the PAI-1 inhibitor, SK-216, to orthotopic mouse models in which MPM cells expressing high levels of VEGF (VEGFA) or bFGF (FGF2) were intrapleurally transplanted. SK-216 administration reduced tumor weights and the degree of angiogenesis in intrapleural tumors, irrespective of their angiogenic expression profiles. In addition, a combination of SK-216 and the chemotherapeutic agent cisplatin significantly reduced tumor weights compared with monotherapy, prolonging the survival of animals compared with cisplatin treatment alone. Furthermore, SK-216 inhibited migration and tube formation of cultured human umbilical vein endothelial cells induced by various angiogenic factors known to be secreted by MPM. These findings suggest that PAI-1 inactivation by SK-216 may represent a general strategy for inhibiting angiogenesis, including for the treatment of MPM. Cancer Res; 76(11); 3285-94. ©2016 AACR. PMID:27197170

  6. Cyclic nucleotide dependent dephosphorylation of regulator of G-protein signaling 18 in human platelets.

    LENUS (Irish Health Repository)

    Gegenbauer, Kristina

    2013-11-01

    Regulator of G-protein signaling 18 (RGS18) is a GTPase-activating protein that turns off Gq signaling in platelets. RGS18 is regulated by binding to the adaptor protein 14-3-3 via phosphorylated serine residues S49 and S218 on RGS18. In this study we confirm that thrombin, thromboxane A2, or ADP stimulate the interaction of RGS18 and 14-3-3 by increasing the phosphorylation of S49. Cyclic AMP- and cyclic GMP-dependent kinases (PKA, PKG) inhibit the interaction of RGS18 and 14-3-3 by phosphorylating S216. To understand the effect of S216 phosphorylation we studied the phosphorylation kinetics of S49, S216, and S218 using Phos-tag gels and phosphorylation site-specific antibodies in transfected cells and in platelets. Cyclic nucleotide-induced detachment of 14-3-3 from RGS18 coincides initially with double phosphorylation of S216 and S218. This is followed by dephosphorylation of S49 and S218. Dephosphorylation of S49 and S218 might be mediated by protein phosphatase 1 (PP1) which is linked to RGS18 by the regulatory subunit PPP1R9B (spinophilin). We conclude that PKA and PKG induced S216 phosphorylation triggers the dephosphorylation of the 14-3-3 binding sites of RGS18 in platelets.

  7. Study of Neutron-Deficient $^{202-205}$Fr Isotopes with Collinear Resonance Ionization Spectroscopy

    CERN Document Server

    De Schepper, Stijn; Cocolios, Thomas; Budincevic, Ivan

    The scope of this master’s thesis is the study of neutron-deficient $^{202−205}$Fr isotopes. These isotopes are inside the neutron-deficient lead region, a region that has shown evidence of shape coexistence. For this thesis, this discussion is limited to the phenomenon where a low lying excited state has a different shape than the ground state. Shape coexistence is caused by intruder states. These are single-particle Shell Model states that are perturbed in energy due to the interaction with a deformed core. In the neutron-deficient lead region the main proton intruder orbit is the 3s$_{1/2}$orbit. When going towards more neutron-deficient isotopes, deformation increases. The $\\pi3s_{1/2}$orbit will rise in energy and will eventually become the ground state in odd- A bismuth (Z=83) isotopes. It is also observed in odd-A astatine (Z=85) isotopes, already in less neutron-deficient nuclei. The same phenomenon is expected to be present francium (Z=87) isotopes already at $^{199}$Fr. Although it is currently ...

  8. The biokinetics of alpha-particle emitting radiopharmaceuticals

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, D.M. [School of Chemistry, Cardiff Univ., Cardiff (United Kingdom); Duffield, J.R. [Faculty of Applied Sciences, Univ. of the West of England, Bristol (United Kingdom)

    2005-07-01

    The past two decades have seen wide interest in the application of alpha-particle emitting radionuclides for targeted endoradiotherapy and a large number of compounds labeled with {sup 211}At (T{sup 1}/{sub 2} 7.21 h), {sup 212}Bi (T{sup 1}/{sub 2} 1 h) or {sup 213}Bi (T{sup 1}/{sub 2} 0.78 h) have been studied. Knowledge of the biokinetic behaviour of such agents is important both for their optimal clinical exploitation and for general radiological protection purposes. Animal studies of the distribution and retention of {sup 211}At compounds, including ionic astatide, substituted aromatic compounds and labelled monoclonal antibodies, have provided new information on the biochemistry of astatine. With respect the thyroid gland the uptake of the astatide ion has been shown to be very much lower than that of the iodide ion. Less information is available for {sup 212}Bi-labelled radiopharmaceuticals. The available data for both {sup 211}At and {sup 212}Bi radiopharmaceuticals are reviewed. Cautious generic biokinetic models for inorganic and simple organic compounds of {sup 211}At and {sup 212}Bi; for [{sup 211}At]-, and [{sup 212}Bi]-biphosphonates and for [{sup 211}At]-, and [{sup 212}Bi]-monoclonal antibodies, are proposed for use in general radiological protection when compound-specific data are not available. (orig.)

  9. Combined effect of gefitinib ('Iressa', ZD1839) and targeted radiotherapy with {sup 211}At-EGF

    Energy Technology Data Exchange (ETDEWEB)

    Sundberg, Aasa Liljegren; Orlova, Anna; Gedda, Lars; Tolmachev, Vladimir; Carlsson, Joergen [Division of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, 751 85, Uppsala (Sweden); Almqvist, Ylva [Division of Radiology, Uppsala University, Uppsala (Sweden); Blomquist, Erik [Division of Oncology, Uppsala University, Uppsala (Sweden); Jensen, Holger J. [Department of Clinical Physiology and Nuclear Medicine, PET and Cyclotron Unit, Rigshospitalet, Copenhagen (Denmark)

    2003-10-01

    The EGFR-TKI (epidermal growth factor receptor tyrosine kinase inhibitor) gefitinib ['Iressa' (trademark of the AstraZeneca group of companies), ZD1839] increases the cellular uptake of radiolabelled epidermal growth factor (EGF). We investigated gefitinib treatment combined with astatine-211 EGF targeting in vitro using two cell lines expressing high levels of EGFR: A431 (sensitive to gefitinib) and U343MGaCl2:1 (resistant to gefitinib). In both cell lines, the uptake of {sup 211}At-EGF was markedly increased by concomitant treatment with gefitinib. Survival was investigated using both a clonogenic survival assay and a cell growth assay. Combined gefitinib and {sup 211}At-EGF treatment reduced the survival of U343 cells 3.5-fold compared with {sup 211}At-EGF alone. In A431 cells, {sup 211}At-EGF treatment resulted in very low survival, but combined treatment with gefitinib increased the survival by about 20-fold. These results indicate that combined treatment with gefitinib might increase the effect of ligand-mediated radionuclide therapy in gefitinib-resistant tumours and decrease the effect of such therapy in gefitinib-sensitive tumours. (orig.)

  10. Alpha particle emitters in medicine

    International Nuclear Information System (INIS)

    Radiation-induced cancer of bone, liver and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High dose rates at high LET, effectiveness under hypoxic conditions, and minimal expectancy of repair are additional advantages of alpha emitters over antibodies labeled with beta emitting radionuclides for cancer therapy. Cyclotron-produced astatine-211 (211At) and natural bismuth-212 (212Bi) have been proposed and are under extensive study in the United States and Europe. Radium-223 (223Ra) also has favorable properties as a potential alpha emitting label, including a short-lived daughter chain with four alpha emissions. The radiation dosimetry of internal alpha emitters is complex due to nonuniformly distributed sources, short particle tracks, and high relative specific ionization. The variations in dose at the cellular level may be extreme. Alpha-particle radiation dosimetry, therefore, must involve analysis of statistical energy deposition probabilities for cellular level targets. It must also account fully for nonuniform distributions of sources in tissues, source-target geometries, and particle-track physics. 18 refs., 4 figs

  11. Tumor Immunotargeting Using Innovative Radionuclides

    Directory of Open Access Journals (Sweden)

    Françoise Kraeber-Bodéré

    2015-02-01

    Full Text Available This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality.

  12. Development of Reagents for Application of At-211 to Targeted Radionuclide Therapy of Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D. Scott

    2011-12-23

    This grant covered only a period of 4 months as the major portion of the award was returned to DOE due to an award of funding from NIH that covered the same research objectives. A letter regarding the termination of the research is attached as the last page of the Final Report. The research conducted was limited due to the short period of this grant, but the results obtained in that period are outlined in the Final Report. The studies addressed in the research effort were directed at a problem that is of critical importance to the in vivo application of the alpha-particle emitting radionuclide At-211. That problem, low in vivo stability of many astatinated molecules, severely limits the use of At-211 in therapeutic applications. The advances sought in the studies were expected to expand the types of biomolecules that can be used as carriers of At-211, and provide improved in vivo targeting of the radiation dose compared with the dose delivered to normal tissue.

  13. Tumor immunotargeting using innovative radionuclides.

    Science.gov (United States)

    Kraeber-Bodéré, Françoise; Rousseau, Caroline; Bodet-Milin, Caroline; Mathieu, Cédric; Guérard, François; Frampas, Eric; Carlier, Thomas; Chouin, Nicolas; Haddad, Ferid; Chatal, Jean-François; Faivre-Chauvet, Alain; Chérel, Michel; Barbet, Jacques

    2015-01-01

    This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality. PMID:25679452

  14. SPECT assay of radiolabeled monoclonal antibodies. Progress report, September 1, 1992--August 24, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Jaszczak, R.J.

    1993-08-20

    The overall goal of this project is to improve the effectiveness of single photon emission computed tomography (SPECT) to image and quantify radiolabeled monoclonal antibodies. During the past year, we have made significant progress toward this goal, and this report summarizes that work. Our efforts have been mainly directed along three fronts. First, we have developed and tested new reconstruction methods including three-dimensional iterative algorithms that model non-uniform attenuation and distance-dependent detector response. Both fan beam and parallel beam collimator geometries have been modeled and novel ways of improving the efficiency of the computationally intensive methods have been introduced. Second, an ultra-high resolution, small field-of-view pinhole collimator has been constructed and evaluated. Reconstructed spatial resolution of 1 to 3 mm (FWHM) has been achieved in phantom scans with a useful field-of-view of 9 to 10 cm. Finally, we have investigated the ability of SPECT to image and quantify astatine-211 distributions. Reconstructed images of phantom data demonstrated quantitative accuracy to within 10% with proper attenuation and scatter compensation.

  15. Silver impregnated nanoparticles of titanium dioxide as carriers for {sup 211}At

    Energy Technology Data Exchange (ETDEWEB)

    Cedrowska, Edyta; Lyczko, Monika; Piotrowska, Agata; Bilewicz, Aleksander [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); Stolarz, Anna; Trcinska, Agnieszka [Warsaw Univ. (Poland). Heavy Ion Lab.; Szkliniarz, Katarzyna [Silesia Univ. Katowice (Poland). Inst. of Physics; Was, Bogdan [Polish Academy of Science, Cracow (Poland). Inst. of Nuclear Physics

    2016-08-01

    The {sup 211}At radioisotope exhibits very attractive nuclear properties for application in radionuclide therapy. Unfortunately use of {sup 211}At is limited, because astatine as the heaviest halogen forms weak bond with carbon atoms in the biomolecules which makes {sup 211}At bioconjugates unstable in physiological conditions. In our work we propose a new solution for binding of {sup 211}At which consists of using nanoparticles of titanium dioxide modified with silver atoms as carriers for {sup 211}At. Ag{sup +} cations have been absorbed on the nanometer-sized TiO{sub 2} particles (15 and 32 nm) through ion exchange process and were reduced in Tollens' reaction. The obtained TiO{sub 2}-Ag nanoparticles were labeled with {sup 211}At. It was found that labeling yields were almost quantitative under reducing conditions, while under oxidizing conditions they dropped to about 80%. The labeled nanoparticles exhibited very high stability in physiological salt, PBS buffer, solutions of peptides (0.001 M cysteine, 0.001 M glutathione) and in human blood serum. To make TiO{sub 2}/Ag nanoparticles well dispersed in water and biocompatible their surface was modified with a silane coupling agent containing poly(ethyleneglycol) molecules. The developed functionalization approach will allow us to attach biomolecules to the TiO{sub 2}/Ag surface.

  16. Nuclear and chemical data for life sciences

    International Nuclear Information System (INIS)

    Use of reactor produced radionuclides is popular in life sciences. However, cyclotron production of proton rich radionuclides are being more focused in recent times. These radionuclides have already gained attention in various fields, including life sciences, provided they are obtained in pure form. This article is a representative brief of our contributions in generating nuclear data for the production of proton rich radionuclides of terbium, astatine, technetium, ruthenium, cadmium, niobium, zirconium, rhenium, etc., which may have application in clinical, biological, agriculture studies or in basic research. The chemical data required to separate the product isotopes from the corresponding target matrix have been presented along with a few propositions of radiopharmaceuticals. It also emphasizes on the development of simple empirical technique, based on the nuclear reaction model analysis, to generate reliable nuclear data for the estimation of yield and angular distribution of emitted neutrons and light charged particles from light as well as heavy ion induced reactions on thick stopping targets. These data bear utmost important in radiation dosimetry. (author)

  17. Studies of Stable Octupole Deformations in the Radium Region

    CERN Multimedia

    2002-01-01

    The purpose of the present project is to locate and identify states in the atomic nuclei possessing stable pearshaped octupole deformation. Such states, formally related to the structures known in molecular physics, manifest themselves as families of parity doublets in odd nuclei.\\\\ \\\\ The best possibilities for observing stable octupole deformations are offered in the Ra-region. Both theoretical calculations and experimental indications support such expectations. Such indications are the non-observation of two-phonon octupole vibrational states in the ISOLDE studies of the even-even radium nuclei, and the reversed sign of the decoupling factor of the ground state band in |2|2|5Ra observed in the single-neutron transfer reactions. In order to establish the predicted strong E1 and E3-transitions between the parity doublets in odd nuclei with stable octupole deformations it is proposed to study conversion electrons in odd-mass francium radium and radon isotopes following the @b-decay of francium and astatine. \\...

  18. Alpha particle emitters in medicine

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, D.R.

    1989-09-01

    Radiation-induced cancer of bone, liver and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High dose rates at high LET, effectiveness under hypoxic conditions, and minimal expectancy of repair are additional advantages of alpha emitters over antibodies labeled with beta emitting radionuclides for cancer therapy. Cyclotron-produced astatine-211 ({sup 211}At) and natural bismuth-212 ({sup 212}Bi) have been proposed and are under extensive study in the United States and Europe. Radium-223 ({sup 223}Ra) also has favorable properties as a potential alpha emitting label, including a short-lived daughter chain with four alpha emissions. The radiation dosimetry of internal alpha emitters is complex due to nonuniformly distributed sources, short particle tracks, and high relative specific ionization. The variations in dose at the cellular level may be extreme. Alpha-particle radiation dosimetry, therefore, must involve analysis of statistical energy deposition probabilities for cellular level targets. It must also account fully for nonuniform distributions of sources in tissues, source-target geometries, and particle-track physics. 18 refs., 4 figs.

  19. An all-digital Manchester symbol synchronizer for Space Shuttle

    Science.gov (United States)

    Batson, B. H.; Vang, H.; Cellier, A.; Lindsey, W. L.

    1974-01-01

    The Shuttle S-Band relay communications links via TDRS are coded and may operate at symbol signal-to-noise ratios (Es/No) as low as -5dB. A brass-board all-digital bit synchronizer with very low (0.05dB) degradation relative to an idealized analog model has been designed to process the 216 KBPS Manchester data symbols. This all-digital bit synchronizer, which provides soft decision detected outputs to a convolutional decoder, may be operated at any rate below 216 KBPS by merely changing the master clock frequency.

  20. Mortality From Fungal Diseases in the US Air Force From 1970 to 2013.

    Science.gov (United States)

    Kugblenu, Richard K; Reeves, Will K

    2016-01-01

    We review a unique set of documents, death certificates, catalogued in the US Air Force Mortality Registry, which tracks deaths for current and retired Air Force service members. We screened the records for all deaths caused by fungal diseases between 1970 and 2013. There were 216 deaths caused by a variety of diseases such as aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, cryptococcosis, histoplasmosis, mucormycosis, pneumocystosis, sporotrichosis, and zygomycosis. The single most common identified cause of death was opportunistic candidiasis. Of the total 216 deaths, only 7 were active duty or active reserve personnel. PMID:27613208

  1. Tandlægers erfaringer med at foreslå og få gennemført behandling med kroner og broer i privat praksis

    DEFF Research Database (Denmark)

    Isidor, F.; Moore, R.

    2003-01-01

    English:What subjective experiences have Danish dentists in private practice to propose and implement treatment with crowns and bridges? A mailed questionnaire were completed and returned by 216 private practice dentists for a random sample from Aarhus. Of these, 22% thought that it was uncomfort......English:What subjective experiences have Danish dentists in private practice to propose and implement treatment with crowns and bridges? A mailed questionnaire were completed and returned by 216 private practice dentists for a random sample from Aarhus. Of these, 22% thought...

  2. Wspomaganie żywieniowe pacjentów geriatrycznych z postępującą sarkopenią = Supporting nutrition in geriatric patients with progressive sarcopenia

    OpenAIRE

    Nowak, Karina; Porażyńska, Daria; Ciesielska, Natalia; Stemplowski, Wojciech; Sokolowski, Remigiusz; Zukow, Walery

    2015-01-01

    Nowak Karina, Porażyńska Daria, Ciesielska Natalia, Stemplowski Wojciech, Sokolowski Remigiusz, Zukow Walery. Wspomaganie żywieniowe pacjentów geriatrycznych z postępującą sarkopenią = Supporting nutrition in geriatric patients with progressive sarcopenia. Journal of Education, Health and Sport. 2015;5(7):216-225. ISSN 2391-8306. DOI 10.5281/zenodo.19940 http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%287%29%3A216-225 https://pbn.nauka.gov.pl/works/583641 ht...

  3. The Process of Reversible Phosphorylation: the Work of Edmond H. Fischer

    Science.gov (United States)

    Kresge, Nicole; Simoni, Robert D.; Hill, Robert L.

    2011-01-01

    Edmond H. Fischer was awarded the 1992 Nobel Prize in Physiology or Medicine for his joint research with Edwin G. Krebs on reversible protein phosphorylation. The two Classics reprinted here relate some of Fischer and Krebs' early discoveries in their phosphorylase research Phosphorylase Activity of Skeletal Muscle Extracts (Krebs, E. G., and Fischer, E. H. (1955) J. Biol. Chem. 216, 113–120) Conversion of Phosphorylase b to Phosphorylase a in Muscle Extracts (Fischer, E. H., and Krebs, E. G. (1955) J. Biol. Chem. 216, 121–132) PMID:21294299

  4. Innovation and R&D Activities in Virtual Team

    OpenAIRE

    Ale Ebrahim, Nader; Ahmed, Shamsuddin; Taha, Zahari

    2009-01-01

    European Journal of Scientific Research ISSN 1450-216X Vol.34 No.3 (2009), pp.297-307 © EuroJournals Publishing, Inc. 2009 EJSR RANKS 43rd AMONG TOP 50 Scientific Journals in Austria "Ale Ebrahim N, Ahmed S, Taha Z. Innovation and R&D Activities in Virtual Team. European Journal of Scientific Research 2009; 34(3): 297-307 (http://www.eurojournals.com/ejsr_34_3_02.pdf)" which has been published in an academic journal namely "European Journal of Scientific Research, ISSN: 1450-216X / 1450-202X"...

  5. Neutron diffraction study of the magnetic long-range order in Tb

    DEFF Research Database (Denmark)

    Dietrich, O.W.; Als-Nielsen, Jens Aage

    1967-01-01

    Like other heavy rare-earth metals, Tb exhibits a magnetic phase with a spiral structure. This appears within the temperature region from 216 to 226deg K between the ferromagnetic phase and the paramagnetic phase. The transition between ferromagnetic and spiral structure is of first order and imp...... at 216deg K to 20.7deg at 226deg K. The temperature variation of the transverse magnetostriction has also been measured and was found to vary approximately in proportion to the square of the magnetic long-range order....

  6. Prevalence and quantification of Listeria monocytogenes in chicken offal at the retail level in Malaysia.

    Science.gov (United States)

    Kuan, C H; Goh, S G; Loo, Y Y; Chang, W S; Lye, Y L; Puspanadan, S; Tang, J Y H; Nakaguchi, Y; Nishibuchi, M; Mahyudin, N A; Radu, S

    2013-06-01

    A total of 216 chicken offal samples (chicken liver = 72; chicken heart = 72; chicken gizzard = 72) from wet markets and hypermarkets in Selangor, Malaysia, were examined for the presence and density of Listeria monocytogenes by using a combination of the most probable number and PCR method. The prevalence of L. monocytogenes in 216 chicken offal samples examined was 26.39%, and among the positive samples, the chicken gizzard showed the highest percentage at 33.33% compared with chicken liver (25.00%) and chicken heart (20.83%). The microbial load of L. monocytogenes in chicken offal samples ranged from Malaysia. PMID:23687164

  7. Herschel/HIFI spectroscopy of the intermediate mass protostar NGC 7129 FIRS 2

    DEFF Research Database (Denmark)

    Johnstone, D.; Fich, M.; McCoey, C.;

    2010-01-01

    Herschel/HIFI observations of water from the intermediate mass protostar NGC 7129 FIRS 2 provide a powerful diagnostic of the physical conditions in this star formation environment. Six spectral settings, covering four H216O and two H218O lines, were observed and all but one H218O line were...... detected. The four H216O lines discussed here share a similar morphology: a narrower, ˜6 km s-1, component centered slightly redward of the systemic velocity of NGC 7129 FIRS 2 and a much broader, ˜25 km s-1 component centered blueward and likely associated with powerful outflows. The narrower components...

  8. Dicty_cDB: SLD766 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available nce from clone DKEY-216E6. 36 0.28 2 ( BD460261 ) Diagnosis of Diseases Associated with Cell Cycle. 44 0.32 ...2 ( BD452183 ) Diagnosis of Diseases Associated with Cell Cycle. 44 0.32 2 ( AX251797 ) Sequence 58 from Pat

  9. Dicty_cDB: Contig-U14508-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available cher AD00P155 cytochrome... 40 3.3 3 ( AY496763 ) Agrodiaetus menalcas menalcas cytochrome oxidase ... 40 3.3 3 ( AY675412 ) Euphilot...es battoides voucher AS92Z166 cytochrome ... 40 3.3 3 ( BV488872 ) S216P61384FA9.T0

  10. 7 CFR 761.1 - Introduction.

    Science.gov (United States)

    2010-01-01

    ... SPECIAL PROGRAMS GENERAL PROGRAM ADMINISTRATION General Provisions § 761.1 Introduction. (a) The... limitations established in 7 CFR 2.16(a)(2) and 7 CFR 2.42. (b) The Deputy Administrator may: (1) Redelegate... 7 Agriculture 7 2010-01-01 2010-01-01 false Introduction. 761.1 Section 761.1...

  11. 26 CFR 31.3221-4 - Exception from supplemental tax.

    Science.gov (United States)

    2010-04-01

    ... CFR 216.42(d) that the plan is a private pension, the payments from which will result in a reduction... 26 Internal Revenue 15 2010-04-01 2010-04-01 false Exception from supplemental tax. 31.3221-4...) EMPLOYMENT TAXES AND COLLECTION OF INCOME TAX AT SOURCE EMPLOYMENT TAXES AND COLLECTION OF INCOME TAX...

  12. Effects of breast cancer related lymphedema on hand muscle strength, hand functions and sensory loss of hand

    Directory of Open Access Journals (Sweden)

    Gul Mete Civelek

    2016-06-01

    Conclusion: In patients with BCRL, having axillary dissection, receiving chemotherapy and radiotherapy in post-operative period, obesity and shoulder pain are common. Evaluation of patients with BCRL should be made in details, should be versatile and should include questioning shoulder pain and hand evaluation. [Cukurova Med J 2016; 41(2.000: 208-216

  13. Attitudes towards the Use of the Internet

    Science.gov (United States)

    Al Otaibi, Khaled Nahes

    2012-01-01

    The main purpose of this study was to investigate the relationship between the attitude towards the use of the Internet and its cognitive, emotional and behavioral components. To achieve the objective of the study, the researcher used the scale of the attitude towards the Internet of a random sample of students (n = 216) at Teachers College at…

  14. 2004 Survey of Adult Protective Services: Abuse of Adults 18 Years of Age and Older

    Science.gov (United States)

    ... for adults 18-59 (21.6%), followed by physical abuse (19.5%), and caregiver neglect/abandonment (18.3%) ( ... third largest category for adults 18-59 was physical abuse (13.2%). Percentages of self-neglect appeared to ...

  15. 76 FR 13629 - Draft Guidance for Industry on Chemistry, Manufacturing, and Controls Information-Fermentation...

    Science.gov (United States)

    2011-03-14

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Chemistry, Manufacturing, and... guidance for industry 216 entitled ``Chemistry, Manufacturing, and Controls (CMC) Information--Fermentation...: The Food and Drug Administration (FDA) is announcing the availability of a draft guidance for...

  16. 76 FR 5070 - Offset of Tax Refund Payments To Collect Delinquent State Unemployment Compensation Debts

    Science.gov (United States)

    2011-01-28

    ... for Elderly and Disabled Refugees Act of 2008 (``2008 Act''), as amended by the Claims Resolution Act....C. 664; E.O. 13019, 61 FR 51763, 3 CFR, 1996 Comp., P. 216. 0 2. Amend Sec. 285.8 as follows: 0 a. Revise the section heading. 0 b. In paragraph (a), revise the definition of ``Debt'', revise...

  17. One Year On: First-Year Primary Teachers' Perceptions of Preparedness to Manage Misbehaviour and Their Confidence in the Strategies They Use

    Science.gov (United States)

    O'Neill, Sue; Stephenson, Jennifer

    2013-01-01

    This article reports the findings of a one-year follow-up study of Australian beginning primary teachers' perceived preparedness to manage a variety of problematic student behaviours, and their confidence and use of behaviour management strategies based on their preservice coursework in classroom behaviour management. A total of 216 primary…

  18. Dicty_cDB: Contig-U12608-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ore = 216 bits (109), Expect = 1e-56 Identities = 248/253 (98%) Strand = Plus / Plus Query: 4 aaaatgctncgagcatgncccagtnaaccnagctaaccn...||||||||||||||||||||||||||||| Sbjct: 4 aaaatgctncgagcatgncccagtnaaccnagctaaccnanaacctgaaagnattgnatt 63 Query...atgatggcgataaaaanananaggatcnaaaatcnactgcttcaaccccccnaggcna 183 ||||||||||||||||||...|||||||||||||||||||||||||||||||||||||||||| Sbjct: 124 ttatgatggcgataaaaanananaggatcnaaaatcnactgcttcaaccccccna...xpect = 2e-05 Identities = 83/105 (79%) Strand = Plus / Plus Query: 150 atcnaaaatcnactgcttcaaccccccnaggcnang

  19. Acupuncture and Moxibustion

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    <正>2015135 Clinical observation on delayed encephalopathy after carbon monoxide poisoning treated with acupuncture to restore consciousness combined with hyperbaric oxygen treatment.MAO Min(茅敏),et al.Neurol Med Dept,Chengdu 1st People’s Hosp,Chengdu610041.Chin Acupunct&Moxibust 2015;35(3):213-216.Objective To compare the efficacy differences on

  20. 41 CFR 102-74.315 - What is the smoking policy for interior space in Federal facilities?

    Science.gov (United States)

    2010-07-01

    ... Employees and the Public From Exposure to Tobacco Smoke in the Federal Workplace” (3 CFR, 1997 Comp., p. 216... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What is the smoking... REGULATION REAL PROPERTY 74-FACILITY MANAGEMENT Facility Management Smoking § 102-74.315 What is the...